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Sample records for agency continued toxic

  1. 77 FR 18248 - Agency for Toxic Substances and Disease Registry; Agency Forms Undergoing Paperwork Reduction Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... HUMAN SERVICES Agency for Toxic Substances and Disease Registry; Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information... in the Navajo Nation--New--Agency for Toxic Substances and Disease Registry (ATSDR) and Centers...

  2. Agency for Toxic Substances and Disease Registry

    MedlinePlus

    ... Mandate Congressional Testimony Board of Scientific Counselors Regional Offices Program Overview ATSDR en Español A-Z Index Multimedia Tools Special Initiatives Publications Sites Toxic Substances Health Registries ...

  3. Mercury toxicity. Agency for Toxic Substance and Disease Registry

    SciTech Connect

    Not Available

    1992-12-01

    Because mercury has several forms and because it produces subtle effects at chronic low-level exposures, mercury toxicity can be a difficult diagnosis to establish. Elemental mercury vapor accounts for most occupational and many accidental exposures. The main source of organic methyl mercury exposure in the general population is fish consumption. Children are at increased risk of exposure to elemental mercury vapor in the home because it tends to settle to the floor. The chemical and physical forms of mercury determine its absorption, metabolism, distribution and excretion pathways. The central nervous system and kidneys are key targets of mercury toxicity. Chelation therapy has been used successfully in treating patients who have ingested mercury salts or inhaled elemental mercury. There is no antidote for patients poisoned with organic mercury.7 references.

  4. Continuing Professional Education Programs of Voluntary Health Agencies.

    ERIC Educational Resources Information Center

    American Medical Association, Chicago, IL.

    Organizational objectives and professional continuing education programs of ten voluntary health agencies--Allergy Foundation of America, American Cancer Society, American Heart Association, Arthritis Foundation, National Association for Mental Health, National Foundation for Infantile Paralysis, National Society for the Prevention of Blindness,…

  5. 77 FR 37678 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry: Notice of Charter... Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and...

  6. 75 FR 43172 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Toxic Substances and Disease Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR): Notice of Charter Renewal This gives notice under...

  7. TOXICITY OF FENVALERATE TO DEVELOPING STEELHEAD TROUT FOLLOWING CONTINUOUS OR INTERMITTENT EXPOSURE

    EPA Science Inventory

    Environmental toxicant exposures commonly vary in terms of duration and concentration. However, laboratory toxicity tests usually entail continuous exposures to constant concentrations. The authors compared survival, growth, and toxicant accumulation in early life-stage steelhead...

  8. 77 FR 30274 - The Commission's Role Regarding the Environmental Protection Agency's Mercury and Air Toxics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    .../pkg/FR-2012-02-16/pdf/2012-806.pdf . I. Introduction 2. On December 21, 2011, the EPA released the... Mercury and Air Toxics Standards; Policy Statement on the Commission's Role Regarding the Environmental Protection Agency's Mercury and Air Toxics Standards Before Commissioners: Jon Wellinghoff, Chairman;...

  9. Agency for Toxic Substances and Disease Registry Brownfields/ land-reuse site tool.

    PubMed

    Perlman, Gary D; Berman, Laurel; Leann, Kathryn; Bing, Lemley

    2012-12-01

    As part of our continuing effort to highlight innovative approaches to improving the health and environment of communities, the Journal is pleased to bring back the bimonthly column from the U.S. Agency for Toxic Substances and Disease Registry (ATSDR). The ATSDR, based in Atlanta, Georgia, is a federal public health agency of the U.S. Department of Health and Human Services and shares a common office of the Director with the National Center for Environmental Health at the Centers for Disease Control and Prevention (CDC). ATSDR serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances. The purpose of this column is to inform readers of ATSDR's activities and initiatives to better understand the relationship between exposure to hazardous substances in the environment and their impact on human health and how to protect public health. We believe that the column will provide a valuable resource to our readership by helping to make known the considerable resources and expertise that ATSDR has available to assist communities, states, and others to assure good environmental health practice for all is served. The conclusions of this article are those of the author(s) and do not necessarily represent the views of ATSDR, CDC, or the U.S. Department of Health and Human Services. Gary D. Perlman is an environmental health scientist for ATSDR. He is a commissioned officer with the U.S. Public Health Service and has been deployed in support of numerous environmental disasters including hurricanes Katrina, Rita, Isabelle, and Irene, as well as the Deepwater Horizon oil spill. Laurel Berman is the national brownfields coordinator with ATSDR. She coordinates the ATSDR Brownfields/Land-Reuse Health Initiative. Kathryn Leann Lemley Bing is an environmental health scientist and an ATSDR regional representative in Atlanta. She has specialized

  10. The U.S. Environmental Protection Agency strategic plan for evaluating the toxicity of chemicals.

    PubMed

    Firestone, Michael; Kavlock, Robert; Zenick, Hal; Kramer, Melissa

    2010-02-01

    In the 2007 report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U.S. National Academy of Sciences envisioned a major transition in toxicity testing from cumbersome, expensive, and lengthy in vivo testing with qualitative endpoints, to in vitro robotic high-throughput screening with mechanistic quantitative parameters. Recognizing the need for agencies to partner and collaborate to ensure global harmonization, standardization, quality control and information sharing, the U.S. Environmental Protection Agency is leading by example and has established an intra-agency Future of Toxicity Testing Workgroup (FTTW). This workgroup has produced an ambitious blueprint for incorporating this new scientific paradigm to change the way chemicals are screened and evaluated for toxicity. Four main components of this strategy are discussed, as follows: (1) the impact and benefits of various types of regulatory activities, (2) chemical screening and prioritization, (3) toxicity pathway-based risk assessment, and (4) institutional transition. The new paradigm is predicated on the discovery of molecular perturbation pathways at the in vitro level that predict adverse health effects from xenobiotics exposure, and then extrapolating those events to the tissue, organ, or whole organisms by computational models. Research on these pathways will be integrated and compiled using the latest technology with the cooperation of global agencies, industry, and other stakeholders. The net result will be that chemical toxicity screening will become more efficient and cost-effective, include real-world exposure assessments, and eliminate currently used uncertainty factors. PMID:20574895

  11. 15 CFR 930.84 - Continuing State agency objections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Consistency for...

  12. 76 FR 24031 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR) In accordance with section 10(a)(2) of the...

  13. 78 FR 32657 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR) In accordance with section 10(a)(2) of...

  14. 78 FR 17213 - Agency for Toxic Substances and Disease Registry Availability of Final Toxicological Profile

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... of the 275 priority substances was announced in the Federal Register on November 3rd, 2011 (76 FR... published in the Federal Register on April 27, 2011 (76 FR 23600), with notice of a 90-day public comment... HUMAN SERVICES Agency for Toxic Substances and Disease Registry Availability of Final...

  15. 76 FR 63623 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR) In accordance with section 10(a)(2) of the...

  16. 77 FR 24720 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR) In... Disease Control and Prevention (CDC), announces the following meeting of the aforementioned...

  17. 77 FR 58557 - Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (BSC, NCEH/ ATSDR) In accordance with section 10(a)(2) of the...

  18. The U. S. Environmental Protection Agency's inhalation RfD methodology: Risk assessment for air toxics

    SciTech Connect

    Jarabek, A.M.; Menache, M.G.; Overton, J.H. Jr.; Dourson, M.L.; Miller, F.J. )

    1990-10-01

    The U.S. Environmental Protection Agency (U.S. EPA) has advocated the establishment of general and scientific guidelines for the evaluation of toxicological data and their use in deriving benchmark values to protect exposed populations from adverse health effects. The Agency's reference dose (RfD) methodology for deriving benchmark values for noncancer toxicity originally addressed risk assessment of oral exposures. This paper presents a brief background on the development of the inhalation reference dose (RfDi) methodology, including concepts and issues related to addressing the dynamics of the respiratory system as the portal of entry. Different dosimetric adjustments are described that were incorporated into the methodology to account for the nature of the inhaled agent (particle or gas) and the site of the observed toxic effects (respiratory or extra-respiratory). Impacts of these adjustments on the extrapolation of toxicity data of inhaled agents for human health risk assessment and future research directions are also discussed.

  19. U. S. Environmental Protection Agency's inhalation RFD methodology: Risk assessment for air toxics

    SciTech Connect

    Jarabek, A.M.; Menache, M.G.; Overton, J.H.; Dourson, M.L.; Miller, F.J.

    1989-01-01

    The U.S. Environmental Protection Agency (U.S. EPA) has advocated the establishment of general and scientific guidelines for the evaluation of toxicological data and their use in deriving benchmark values to protect exposed populations from adverse health effects. The Agency's reference dose (RfD) methodology for deriving benchmark values for noncancer toxicity originally addressed risk assessment of oral exposures. The paper presents a brief background on the development of the inhalation reference dose (RFDi) methodology, including concepts and issues related to addressing the dynamics of the respiratory system as the portal of entry. Different dosimetric adjustments are described that were incorporated into the methodology to account for the nature of the inhaled agent (particle or gas) and the site of the observed toxic effects (respiratory or extrarespiratory). Impacts of these adjustments on the extrapolation of toxicity data of inhaled agents for human health risk assessment and future research directions are also discussed.

  20. 40 CFR 707.65 - Submission to agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 707.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200..., Environmental Protection Agency, 1201 Constitution Ave., NW., Washington, DC (Attention: TSCA Section...

  1. 40 CFR 707.65 - Submission to agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 707.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200..., Environmental Protection Agency, 1201 Constitution Ave., NW., Washington, DC (Attention: TSCA Section...

  2. 40 CFR 707.65 - Submission to agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 707.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200..., Environmental Protection Agency, 1201 Constitution Ave., NW., Washington, DC (Attention: TSCA Section...

  3. 40 CFR 707.65 - Submission to agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 707.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200..., Environmental Protection Agency, 1201 Constitution Ave., NW., Washington, DC (Attention: TSCA Section...

  4. 78 FR 36560 - Agency Information Collection Activities: Distribution of Continued Dumping and Subsidy Offset to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... Continued Dumping and Subsidy Offset to Affected Domestic Producers AGENCY: U.S. Customs and Border... of Continued Dumping and Subsidy Offset to Affected Domestic Producers (CDSOA). This request for... concerning the following information collection: Title: Distribution of Continued Dumping and Subsidy...

  5. 78 FR 55280 - Agency Information Collection Activities: Distribution of Continued Dumping and Subsidy Offset to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Register (78 FR 36560) on June 18, 2013, allowing for a 60-day comment period. This notice allows for an... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Distribution of Continued Dumping and Subsidy Offset to Affected Domestic Producers AGENCY: U.S. Customs and...

  6. 75 FR 36106 - Agency Information Collection Activities: Distribution of Continued Dumping and Subsidy Offset to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... Federal Register (75 FR 16493) on April 1, 2010, allowing for a 60-day comment period. One comment was... Continued Dumping and Subsidy Offset to Affected Domestic Producers (CDSOA) AGENCY: U.S. Customs and Border...: Distribution of Continued Dumping and Subsidy Offset to Affected Domestic Procedures. This is a...

  7. 75 FR 16493 - Agency Information Collection Activities: Distribution of Continued Dumping and Subsidy Offset to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Continued Dumping and Subsidy Offset to Affected Domestic Producers (CDSOA) AGENCY: U.S. Customs and Border... Dumping and Subsidy Offset to Affected Domestic Procedures. This request for comment is being made... Continued Dumping and Subsidy Offset to Affected Domestic Producers (CDSOA). OMB Number: 1651-0086....

  8. Integration of site-specific health information: Agency for Toxic Substances and Disease Registry health assessments

    SciTech Connect

    Lesperance, A.M.; Siegel, M.R.

    1990-12-01

    The Agency for Toxic Substances and Disease Registry is required to conduct a health assessment of any site that is listed on or proposed for the US Environmental Protection Agency's National Priorities List. Sixteen US Department of Energy (DOE) sites currently fall into this category. Health assessments contain a qualitative description of impacts to public health and the environment from hazardous waste sites, as well as recommendations for actions to mitigate or eliminate risk. Because these recommendations may have major impacts on compliance activities at DOE facilities, the health assessments are an important source of information for the monitoring activities of DOE's Office of Environmental Compliance (OEC). This report provides an overview of the activities involved in preparing the health assessment, its role in environmental management, and its key elements.

  9. No-observed-effect concentrations in batch and continuous algal toxicity tests

    SciTech Connect

    Chao, M.R.; Chen, C.Y.

    2000-06-01

    In this study, the authors compare the no-observed-effect concentrations (NOECs) of Cd, Ni, Zn, Cu, and Pb based on different response parameters, using batch and continuous algal toxicity tests. For both batch and continuous tests, parameters based on total cell volume (TCV) were found to be less sensitive than those related to cell densities. The above observation mainly occurred because, under the stresses from metal toxicants evaluated in this and a previous study, the mean cell volume (MCV) of algae increased considerably. The increase of MCV compensates for the effects brought about by the reduction in cell density and eventually results in less variation in TCVs. This study shows that parameters based on cell density are quite sensitive and ideal for the estimation of NOECs. In addition, comparison of the NOEC values derived from different culture techniques shows that the continuous methods generally yields lower NOEC values than that obtained by the batch tests. The results of this study also indicate that the NOEC provides more protection to the test organism than the effective concentration at 10% growth reduction (EC10). For toxicity test methods that produce small variations among replicates, the NOEC is still a good indicator of low toxic effect. Furthermore, for the continuous algal toxicity test, a relatively simple approach is proposed to determine the NOEC values based on the algal culture's control charts. The proposed method produced identical results as those based on conventional hypothesis-testing methods.

  10. Relationships of Academia, Professions and Agencies. Continuing Education in Mental Health.

    ERIC Educational Resources Information Center

    Southern Regional Education Board, Atlanta, GA.

    These guidelines for relationships of academia, professions, and agencies in mental health were developed for persons responsible for conducting professional continuing education programs in mental health. Following a brief introduction and definitions of terms, content is presented in six sections covering the following areas, respectively: (1)…

  11. Semi-continuous detection of toxic hexavalent chromium using a sulfur-oxidizing bacteria biosensor.

    PubMed

    Gurung, Anup; Oh, Sang-Eun; Kim, Ki Duck; Shin, Beom-Soo

    2012-09-15

    Toxicity testing is becoming a useful tool for environmental risk assessment. A biosensor based on the metabolic properties of sulfur-oxidizing bacteria (SOB) has been applied for the detection of toxic chemicals in water. The methodology exploits the ability of SOB to oxidize elemental sulfur to sulfuric acid under aerobic conditions. The reaction results in an increase in electrical conductivity (EC) and a decrease in pH. Five hours after Cr(6+) was added to the SOB biosensor operated in semi-continuous mode (1 min rapid feeding and 29 min batch reaction), a decrease in effluent EC and an increase in pH (from 2-3 to 6) were detected due to Cr(6+) toxicity to SOB. The SOB biosensor is simple; it can detect toxic levels of Cr(6+) on the order of minutes to hours, a useful time scale for early warning detection systems designed to protect the environment from further degradation. PMID:22647672

  12. A Microfluidic Device for Continuous Sensing of Systemic Acute Toxicants in Drinking Water

    PubMed Central

    Zhao, Xinyan; Dong, Tao

    2013-01-01

    A bioluminescent-cell-based microfluidic device for sensing toxicants in drinking water was designed and fabricated. The system employed Vibrio fischeri cells as broad-spectrum sensors to monitor potential systemic cell toxicants in water, such as heavy metal ions and phenol. Specifically, the chip was designed for continuous detection. The chip design included two counter-flow micromixers, a T-junction droplet generator and six spiral microchannels. The cell suspension and water sample were introduced into the micromixers and dispersed into droplets in the air flow. This guaranteed sufficient oxygen supply for the cell sensors. Copper (Cu2+), zinc (Zn2+), potassium dichromate and 3,5-dichlorophenol were selected as typical toxicants to validate the sensing system. Preliminary tests verified that the system was an effective screening tool for acute toxicants although it could not recognize or quantify specific toxicants. A distinct non-linear relationship was observed between the zinc ion concentration and the Relative Luminescence Units (RLU) obtained during testing. Thus, the concentration of simple toxic chemicals in water can be roughly estimated by this system. The proposed device shows great promise for an early warning system for water safety. PMID:24300075

  13. The findings of the Agency for Toxic Substances and Disease Registry Medical Waste Tracking Act report.

    PubMed Central

    Lichtveld, M Y; Rodenbeck, S E; Lybarger, J A

    1992-01-01

    The Agency for Toxic Substances and Disease Registry (ATSDR) report "The Public Health Implications of Medical Waste: A Report to Congress" has been finalized and submitted to Congress. The report is a comprehensive review of all available data and information on the subject. Based on the data developed in the report, ATSDR concludes that the general public is not likely to be adversely affected by medical waste generated in the traditional health setting. However, the increase of in-home health care and other sources of nonregulated medical waste (e.g., intravenous drug users) provides opportunities for the general public to contact medical waste. In addition, ATSDR concludes that public health concerns exist for selected occupations involved with medical waste. These populations include janitorial and laundry workers, nurses, emergency medical personnel, and refuse workers. The ATSDR report also defines what material should be managed as medical waste and identifies research needs related to medical waste. PMID:1486856

  14. Ammonia toxicity to the freshwater planarian Polycelis felina: contrasting effects of continuous versus discontinuous exposures.

    PubMed

    Alonso, Álvaro; Camargo, Julio A

    2015-05-01

    Aquatic animals can be exposed to fluctuating concentrations of toxicants. In fact, for some toxicants (i.e., pesticides, ammonia), discontinuous exposure is more environmentally relevant than constant exposure. Responses of aquatic animals to each type of exposure may be different. However, despite the high ecological relevance of behaviour, there is still scarce information on the effects of discontinuous exposure on behaviour. Our study focused on the assessment of unionized ammonia toxicity on the behaviour of a freshwater planarian under continuous exposure (3 days of exposure and 18 days of recovery) versus discontinuous exposure (3 pulses of 1 day with 6 days of recovery between pulses = total 3 days of exposure and 18 days of recovery). Behaviour was assessed as locomotion activity. Bioassays with continuous and discontinuous exposure were performed with one control and five unionized ammonia concentrations (0.14-0.35 mg N-NH3/L). Unionized ammonia in continuous exposure caused less impact on behaviour than equivalent concentrations provided in a discontinuous exposure. By contrast, continuous exposures caused more impact on survival. The discontinuous exposure may allow detoxification during recovery periods, thus increasing the probability of survival in the next pulse. Under continuous exposure, the mortality threshold could be exceeded, and animals could die in greater proportion during exposure as well as the recovery period. We conclude that behavioural activity was a sensitive endpoint to assess the contrasting effects of continuous versus discontinuous exposure and that the response of planarians to discontinuous exposure is different to its response to continuous exposure. PMID:25604922

  15. Continuous ozonation treatment of ofloxacin: transformation products, water matrix effect and aquatic toxicity.

    PubMed

    Carbajo, Jose B; Petre, Alice L; Rosal, Roberto; Herrera, Sonia; Letón, Pedro; García-Calvo, Eloy; Fernández-Alba, Amadeo R; Perdigón-Melón, Jose A

    2015-07-15

    The continuous ozonation of the antibiotic ofloxacin (OFX) has been performed using a synthetic water matrix and in a sewage treatment plant (STP) effluent. The aim was to study the effect of the water matrix on the ozonation with particular emphasis on the aquatic toxicity of treated water. OFX was completely removed in both water matrices, although the amount of ozone consumed for its depletion was strongly matrix-dependent. The extent of mineralization was limited and a number of intermediate transformation products (TPs) appeared, twelve of which could be identified. OFX reaction pathway includes the degradation of piperazinyl and quinolone moieties. The further oxidation of TPs gave rise to the formation and accumulation of carboxylic acids, aldehydes, nitrogen-containing organic compounds and inorganic ions. Aquatic toxicity of treated mixtures was assessed using four standard species: the bacteria Vibrio fischeri and Pseudomonas putida as target organisms and the algae Pseudokirchneriella subcapitata and the protozoan Tetrahymena thermophila as non-target organisms. OFX was toxic for the bacteria and the microalgae at the spiked concentration in untreated water. However, the continuous ozonation at the upper operational limit removed its toxic effects. T. thermophila was not affected by OFX, but was sensitive to STP effluent. PMID:25796038

  16. [Enzymes of the Xenobiotic Metabolism of Continuous Cell Lines in invitro Toxicity Testing

    PubMed

    Wiebel, Friedrich J.; Roscher, Eike

    1988-01-01

    Cells in continuous culture contain a large number of enzymes which are involved in the metabolism of potentially toxic chemicals. As a rule, the activities of these enzymes represent functions of low tussle specificity. In contrast, those functions which are specialized "differentiated" functions in vivo are no longer expressed in continuous cell lines. However, an increasing number of observations indicates that cell lines may also contain these functions. Cell lines which lack or possess specific xenobiotic metabolizing enzymes are already applicable for analyzing the complex mechanisms of activation and inactivation of chemicals. With a better understanding how differentiated cell functions are regulated, prospects are promising for establishing metabolically competent cell lines, which can also be used in the screening of toxic chemicals. PMID:11227057

  17. 41 CFR 102-85.205 - What happens if a customer agency continues occupancy after the expiration of an OA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assignments. However, provisions are necessary to cover the GSA and customer relationship if an OA expires... customer agency continues occupancy after the expiration of an OA? 102-85.205 Section 102-85.205 Public..., Relocation and Forced Moves § 102-85.205 What happens if a customer agency continues occupancy after...

  18. 75 FR 16488 - National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR); Notice of National Conversation on Public Health and Chemical Exposures Leadership...

  19. 75 FR 60762 - Board of Scientific Counselors (BSC), National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS) Centers for Disease Control and Prevention Board of Scientific Counselors (BSC), National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR) In accordance with section 10(a)(2) of...

  20. 75 FR 25870 - Board of Scientific Counselors (BSC), National Center for Environmental Health/Agency for Toxic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors (BSC), National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR) In accordance with Section 10(a)(2) of the...

  1. 75 FR 41505 - National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR) ATSDR-263; Notice of National Conversation on Public Health and Chemical...

  2. 75 FR 75474 - National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR); Notice of National Conversation on Public Health and Chemical Exposures Leadership...

  3. 75 FR 59727 - National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR); Notice of National Conversation on Public Health and Chemical Exposures Leadership...

  4. A simple toxicity apparatus for continuous flow with small volumes: demonstration with mysids and naphthalene

    SciTech Connect

    Smith, R.L.; Hargreaves, B.R.

    1983-04-01

    To determine the toxicity of naphthalene to the mysid crustacean Neomysis americana a small continuous-flow toxicant exposure system was built using design features of Mariotte bottle chemostats. Chemostats maintain cultures at constant cell concentrations by providing constant nutrient inputs. Such cultures remain well-mixed and have minimal cell contact with the container. The same characteristics are useful for exposing small invertebrates to volatile toxicants. The Mariotte bottles in the exposure system were modified by addition of air inlet restrictors. This modification provided stable flow at low pressure heads. The apparatus provided good water quality and physical environment for 10 mysids per chamber, and a more constant concentration of naphthalene than did static chambers replenished daily. Preliminary 96 h toxicity tests with N. americana were performed at 15/sup 0/C and 25/sup 0/C at concentrations of 900 and 1800 ..mu..g l/sup -1/ naphthalene in artificial seawater, for comparison with similar tests performed under static conditions. (JMT)

  5. The U.S. Environmental Protection Agency's inhalation RfD methodology: risk assessment for air toxics.

    PubMed

    Jarabek, A M; Menache, M G; Overton, J H; Dourson, M L; Miller, F J

    1990-10-01

    The U.S. Environmental Protection Agency (U.S. EPA) has advocated the establishment of general and scientific guidelines for the evaluation of toxicological data and their use in deriving benchmark values to protect exposed populations from adverse health effects. The Agency's reference dose (RfD) methodology for deriving benchmark values for noncancer toxicity originally addressed risk assessment of oral exposures. This paper presents a brief background on the development of the inhalation reference dose (RfDi) methodology, including concepts and issues related to addressing the dynamics of the respiratory system as the portal of entry. Different dosimetric adjustments are described that were incorporated into the methodology to account for the nature of the inhaled agent (particle or gas) and the site of the observed toxic effects (respiratory or extrarespiratory). Impacts of these adjustments on the extrapolation of toxicity data of inhaled agents for human health risk assessment and future research directions are also discussed. PMID:1670284

  6. Comparison of heavy metal toxicity in continuous flow and batch reactors

    NASA Astrophysics Data System (ADS)

    Sengor, S. S.; Gikas, P.; Moberly, J. G.; Peyton, B. M.; Ginn, T. R.

    2009-12-01

    The presence of heavy metals may significantly affect microbial growth. In many cases, small amounts of particular heavy metals may stimulate microbial growth; however, larger quantities may result in microbial growth reduction. Environmental parameters, such as growth pattern may alter the critical heavy metal concentration, above which microbial growth stimulation turns to growth inhibition. Thus, it is important to quantify the effects of heavy metals on microbial activity for understanding natural or manmade biological reactors, either in situ or ex situ. Here we compare the toxicity of Zn and Cu on Arthrobacter sp., a heavy metal tolerant microorganism, under continuous flow versus batch reactor operations. Batch and continuous growth tests of Arthrobacter sp. were carried out at various individual and combined concentrations of Zn and Cu. Biomass concentration (OD) was measured for both the batch and continuous reactors, whereas ATP, oxygen uptake rates and substrate concentrations were additionally measured for the continuous system. Results indicated that Cu was more toxic than Zn under all conditions for both systems. In batch reactors, all tested Zn concentrations up to 150 uM showed a stimulatory effect on microbial growth. However, in the case of mixed Zn and Cu exposures, the presence of Zn either eliminated (at the 50 uM level both Zn and Cu) or reduced by ~25% (at the 100 and 150 uM levels both Zn and Cu) the Cu-induced inhibition. In the continuous system, only one test involved combined Cu (40uM) and Zn (125uM) and this test showed similar results to the 40uM Cu continuous test, i.e., no reduction in inhibition. The specific ATP concentration, i.e., ATP/OD, results for the continuous reactor showed an apparent recovery for both Cu-treated populations, although neither the OD nor glucose data showed any recovery. This may reflect that the individual microorganisms that survived after the addition of heavy metals, kept maintaining the usual ATP

  7. Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion.

    PubMed

    Li, Guisheng; Gao, Yonglin; Li, Shenjun; Li, Chunmei; Zhu, Xiaoyin; Li, Min; Liu, Zhifeng

    2009-09-01

    Danshensu (3-(3,4-dihydroxyphenyl) lactic acid), a natural phenolic acid, is isolated from root of Salvia miltiorrhiza, and is widely used as a traditional Chinese medicine for treatment of various cardiovascular diseases. In the present study, toxicity of danshensu was evaluated in male and female dogs after 3-month continuous intravenous infusion. Beagle dogs were treated with danshensu at doses of 17, 50, and 150 mg/kg/day, and observed for 90 days followed by recovery periods. Measurements included clinical observations, body weight, food consumption, temperature, electro-cardiography (EGC), hematology, blood chemistry, urinalysis, gross necropsy, organ weight, and histopathology. No significant adverse effects on these parameters were observed. The only treatment-related finding was a hard knot at injection site observed in the 150 mg/kg group after 2-3 weeks continuous administration, and returned to normal after 3-4 days withdrawal. From these results, it might be concluded that danshensu did not produce any significant cumulative toxicity at the doses administered, as reflected by the various parameters investigated. PMID:19778246

  8. 40 CFR 798.2450 - Inhalation toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Inhalation toxicity. 798.2450 Section 798.2450 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Subchronic Exposure § 798.2450 Inhalation toxicity. (a) Purpose. In the assessment...

  9. 40 CFR 798.2650 - Oral toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Oral toxicity. 798.2650 Section 798.2650 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Subchronic Exposure § 798.2650 Oral toxicity. (a) Purpose. In the assessment and evaluation of...

  10. 40 CFR 798.2250 - Dermal toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Dermal toxicity. 798.2250 Section 798.2250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Subchronic Exposure § 798.2250 Dermal toxicity. (a) Purpose. In the assessment and evaluation of...

  11. 40 CFR 798.3260 - Chronic toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Chronic toxicity. 798.3260 Section 798.3260 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Chronic Exposure § 798.3260 Chronic toxicity. (a) Purpose. The objective of a chronic...

  12. 76 FR 7841 - Agency Information Collection Activities; Proposed Collections; Toxic Chemical Release Reporting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... Ratio-Based Burden Methodology AGENCY: Environmental Protection Agency. ACTION: Notice. SUMMARY: In... to Ratio-Based Methodology,'' describes the nature of the information collection (including proposed... the burden of the proposed collection of information, including the validity of the new...

  13. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Does a State VR agency continue to provide... Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State VR.... The State VR agency must continue to provide services under the requirements of the State...

  14. U.S. ENVIRONMENTAL PROTECTION AGENCY (EPA) ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: MERCURY CONTINUOUS EMISSION MONITORS

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techn...

  15. Continuous Emission Monitor for Toxic Metals in the Off-Gases of Thermal Treatment Facilities

    SciTech Connect

    Gary Loge

    1998-12-01

    Self-calibration procedures for continuous monitoring of toxic metals in the off-gases of thermal treatment facilities using laser-induced breakdown spectroscopy (LIBS) were tested. The tests were performed using a heated aerosol/gas flow system that generated simulated off-gas conditions with calibrated amounts of metal in an optical cell. Calibration curves of LIBS signal for metal concentration in the cell were obtained for various gas and optical conditions. Gas conditions that were varied include water in either vapor and condensed aerosol droplet form, the presence of easily ionizable elements (i. e., potassium), speciation of the metal analyte, and the gas temperature. In addition, laser pulse energy, focal length, and detector alignment were independently varied. Two different sets of calibration curves were obtained, one set with Mn(II) and N(II) emission obtained simultaneously and a second set with Cd(I) and Cd(II) emission obtained simultaneously with N(I) emission obtained in a sequential manner. For both sets of data, calibration curves were obtained using 1) single line intensities, 2) the ratio of metal single line intensity to nitrogen single line intensity, and 3) the ratio of total metal emission to total nitrogen emission obtained using the temperature and electron density. Results show that correction using the ratio of metal single line intensity to nitrogen single line intensity does help in maintaining a constant slope of calibration curves for various conditions. However, the total emission self-calibration procedure shows better performance in most cases.

  16. Bolivian Teachers' Agency: Soldiers of Liberation or Guards of Coloniality and Continuation?

    ERIC Educational Resources Information Center

    Lopes Cardozo, Mieke T. A.

    2015-01-01

    This paper investigates the problems and promises of teachers' agency associated with Bolivia's current "decolonising" education reform. The Avelino Siñani Elizardo Pérez (ASEP) education reform is part of a counter-hegemonic and anti-neoliberal policy that aims to advance the political project of the government of Evo Morales,…

  17. Automated Lab-on-a-Chip Technology for Fish Embryo Toxicity Tests Performed under Continuous Microperfusion (μFET).

    PubMed

    Zhu, Feng; Wigh, Adriana; Friedrich, Timo; Devaux, Alain; Bony, Sylvie; Nugegoda, Dayanthi; Kaslin, Jan; Wlodkowic, Donald

    2015-12-15

    The fish embryo toxicity (FET) biotest has gained popularity as one of the alternative approaches to acute fish toxicity tests in chemical hazard and risk assessment. Despite the importance and common acceptance of FET, it is still performed in multiwell plates and requires laborious and time-consuming manual manipulation of specimens and solutions. This work describes the design and validation of a microfluidic Lab-on-a-Chip technology for automation of the zebrafish embryo toxicity test common in aquatic ecotoxicology. The innovative device supports rapid loading and immobilization of large numbers of zebrafish embryos suspended in a continuous microfluidic perfusion as a means of toxicant delivery. Furthermore, we also present development of a customized mechatronic automation interface that includes a high-resolution USB microscope, LED cold light illumination, and miniaturized 3D printed pumping manifolds that were integrated to enable time-resolved in situ analysis of developing fish embryos. To investigate the applicability of the microfluidic FET (μFET) in toxicity testing, copper sulfate, phenol, ethanol, caffeine, nicotine, and dimethyl sulfoxide were tested as model chemical stressors. Results obtained on a chip-based system were compared with static protocols performed in microtiter plates. This work provides evidence that FET analysis performed under microperfusion opens a brand new alternative for inexpensive automation in aquatic ecotoxicology. PMID:26506399

  18. ATSDR evaluation of health effects of chemicals. VI. Di(2-ethylhexyl)phthalate. Agency for Toxic Substances and Disease Registry.

    PubMed

    Fay, M; Donohue, J M; De Rosa, C

    1999-12-01

    Di(2-ethylhexyl)phthalate (also known as DEHP, bis(2-ethylhexyl)phthalate, or BEHP; CAS Registry Number 117-81-7) is a widely-used plasticizer. It is found in numerous plastic articles, such as paints, inks, floor tiles, upholstery, shower curtains, footwear, plastic bags, food-packaging materials, toys, and medical tubing. Not surprisingly, DEHP appears at many waste sites. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals that are of greatest public health concern at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priority List (NPL) sites. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of ATSDR's profile for DEHP (ATSDR, 1993) into the mainstream scientific literature. An extensive listing of human and animal health effects, organized by route, duration, and endpoint, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, at the behest of Congress and therefore the citizenry, prepares these profiles to inform the public about site contaminants. PMID:10786378

  19. 40 CFR 798.3320 - Combined chronic toxicity/oncogenicity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Combined chronic toxicity/oncogenicity. 798.3320 Section 798.3320 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Chronic Exposure § 798.3320 Combined chronic toxicity/oncogenicity....

  20. 40 CFR 797.1400 - Fish acute toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Fish acute toxicity test. 797.1400 Section 797.1400 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1400 Fish acute toxicity test. (a) Purpose. This...

  1. 40 CFR 797.1300 - Daphnid acute toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Daphnid acute toxicity test. 797.1300 Section 797.1300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1300 Daphnid acute toxicity test. (a) Purpose....

  2. 40 CFR 795.120 - Gammarid acute toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Gammarid acute toxicity test. 795.120 Section 795.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) PROVISIONAL TEST GUIDELINES Provisional Environmental Effects Guidelines § 795.120 Gammarid acute toxicity test....

  3. 40 CFR 797.1930 - Mysid shrimp acute toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Mysid shrimp acute toxicity test. 797.1930 Section 797.1930 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1930 Mysid shrimp acute toxicity test. (a)...

  4. 40 CFR 797.1330 - Daphnid chronic toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Daphnid chronic toxicity test. 797.1330 Section 797.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1330 Daphnid chronic toxicity test. (a) Purpose....

  5. 40 CFR 797.1050 - Algal acute toxicity test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Algal acute toxicity test. 797.1050 Section 797.1050 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1050 Algal acute toxicity test. (a) Purpose. The...

  6. 40 CFR 791.85 - Availability of final Agency order.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Availability of final Agency order. 791.85 Section 791.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Final Order § 791.85 Availability of final Agency...

  7. 40 CFR 791.85 - Availablity of final Agency order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Availablity of final Agency order. 791.85 Section 791.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Final Order § 791.85 Availablity of final Agency...

  8. 40 CFR 791.85 - Availablity of final Agency order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Availablity of final Agency order. 791.85 Section 791.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Final Order § 791.85 Availablity of final Agency...

  9. 40 CFR 791.85 - Availability of final Agency order.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Availability of final Agency order. 791.85 Section 791.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Final Order § 791.85 Availability of final Agency...

  10. 40 CFR 791.85 - Availability of final Agency order.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Availability of final Agency order. 791.85 Section 791.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT Final Order § 791.85 Availability of final Agency...

  11. 40 CFR 799.9365 - TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA combined repeated dose toxicity study with the reproduction/developmental toxicity screening test. 799.9365 Section 799.9365 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL...

  12. 41 CFR 102-85.200 - Can customer agencies continue occupancy of space or must they relocate at the end of an OA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... continue occupancy of space or must they relocate at the end of an OA? 102-85.200 Section 102-85.200 Public... MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.200 Can customer agencies continue occupancy of space or must...

  13. 41 CFR 102-85.200 - Can customer agencies continue occupancy of space or must they relocate at the end of an OA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... continue occupancy of space or must they relocate at the end of an OA? 102-85.200 Section 102-85.200 Public... MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.200 Can customer agencies continue occupancy of space or must...

  14. 41 CFR 102-85.200 - Can customer agencies continue occupancy of space or must they relocate at the end of an OA?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... continue occupancy of space or must they relocate at the end of an OA? 102-85.200 Section 102-85.200 Public... MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.200 Can customer agencies continue occupancy of space or must...

  15. 40 CFR 80.820 - What gasoline is subject to the toxics performance requirements of this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false What gasoline is subject to the toxics... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Gasoline Toxics Performance Requirements § 80.820 What gasoline is subject to the toxics...

  16. 40 CFR 80.820 - What gasoline is subject to the toxics performance requirements of this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false What gasoline is subject to the toxics... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Gasoline Toxics Performance Requirements § 80.820 What gasoline is subject to the toxics...

  17. 40 CFR 80.820 - What gasoline is subject to the toxics performance requirements of this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false What gasoline is subject to the toxics... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Gasoline Toxics Performance Requirements § 80.820 What gasoline is subject to the toxics...

  18. 40 CFR 80.820 - What gasoline is subject to the toxics performance requirements of this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false What gasoline is subject to the toxics... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Gasoline Toxics Performance Requirements § 80.820 What gasoline is subject to the toxics...

  19. 40 CFR 80.820 - What gasoline is subject to the toxics performance requirements of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What gasoline is subject to the toxics... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Gasoline Toxics Performance Requirements § 80.820 What gasoline is subject to the toxics...

  20. Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps.

    PubMed

    Sepúlveda, M R; Dresselaers, T; Vangheluwe, P; Everaerts, W; Himmelreich, U; Mata, A M; Wuytack, F

    2012-01-01

    Manganese is a vital element and cofactor of many key enzymes, but it is toxic at high levels, causing pronounced disturbances in the mammalian brain. Magnetic resonance imaging (MRI) studies using manganese ions as a paramagnetic contrast agent are often limited by the neurotoxicity of Mn(2+) . In this work, we have explored a new in vivo model to study Mn(2+) uptake, distribution and neurotoxicity in mice by subcutaneous implantation of mini-osmotic pumps delivering MnCl(2) continuously for 21 days. Fractionated injections can reduce the toxicity; however, constant administration at very low doses using osmotic pumps caused a substantial effect on the T(1) contrast in MRI while reducing toxicity. Manganese-enhanced MRI documented fast but reversible Mn(2+) deposition largely in glomerular and mitral cell layers of the olfactory bulb, in the CA3 area of the hippocampus, and in the gray matter of the cerebellum. Mn(2+) accumulated as early as the first days after implantation, with a fast dispersal 9 days after stopping a 12-days Mn(2+) exposure. Prominent Mn(2+) accumulation was also seen in salivary glands and in the endocrine thyroid and posterior pituitary gland. These structures with enhanced Mn(2+) accumulation correlated well with those showing high expression of the secretory pathway Ca(2+) /Mn(2+) -ATPase (SPCA1), i.e. a transporter that could take part in Mn(2+) detoxification. Our new experimental model for continuous low-dosage administration of Mn(2+) is an easy alternative for enhancing Mn(2+) -based contrast in MEMRI studies, and might provide insight into the etiology of neuropathologies resulting from chronic Mn(2+) exposure in vivo. PMID:22649049

  1. Prognostic relevance of sunitinib toxicities and comparison of continuous vs. intermittent sunitinib dosing schedule in metastatic renal cell cancer patients

    PubMed Central

    Pilanci, Kezban N.; Avcı, Nilüfer; Yıldız, İbrahim; Alço, Gül; Demirhan, Özkan; Köksal, Ülkühan I.; Elbüken, Filiz; Tecimer, Coskun; Demir, Gökhan

    2016-01-01

    Aim of the study Sunitinib-related side effects may develop as a result of the pharmacokinetic pathway affects the of the drug. Material and methods Data on mRCC patients were obtained from the hospital archives. Outcomes of patients were evaluated in terms of related prognostic factors, sunitinib adverse events during the treatment, and two different sunitinib dosing schedules. Results Seventy patients diagnosed with mRCC and treated with sunitinib were analyzed for prognostic factors and survival rates. During the mean follow-up of 33.5 months, 38 (54%) patients were alive and 32 (46%) patients died. The median time of overall survival (OS) and progression-free survival (PFS) was 27 months (12–61) and 19 months (5–45), respectively. In univariate analysis, good prognostic risk group according to the Memorial Sloan-Kettering Cancer Center (MSKCC), hypothyroidism as sunitinib toxicity and patients on sunitinib treatment more than 1 year were favorable prognostic factors for OS. Leukopenia and fatigue as sunitinib toxicity were poor prognostic factors for OS. PFS and OS of the patients were not significantly different when we compared intermittent (4/2) vs. continuous treatment dosing schedules. Conclusions As a result of this trial, having hypothyroidism as an adverse effect of sunitinib was a favorable prognostic factor for OS and PFS in mRCC patients. It was also found that 4/2 and continuous dosing schedules of sunitinib did not give rise to different outcomes in mRCC patients. PMID:27358594

  2. Lipid rescue for treatment of delayed systemic ropivacaine toxicity from a continuous thoracic paravertebral block.

    PubMed

    Tsang, Trylon Mathew; Okullo, Alfin Taddeo; Field, Jeremy; Mamo, Patrick

    2016-01-01

    A 66-year-old man underwent a left minithoracotomy for pleural biopsies and thoracentesis. A left T3 paravertebral catheter was placed prior to induction of general anaesthesia, and a total of 20 mL of bupivacaine 0.25% administered. Postoperatively, ropivacaine 0.2% infusion was commenced at 10 mL/hour. Thirty-seven hours after the initial block, the patient developed convulsions without loss of consciousness. The ropivacaine infusion rate was unchanged and no further boluses had been given. He reported of perioral tingling, a burning sensation in his legs and penis and agitation. Ropivacaine infusion was ceased and a bolus of lipid emulsion (Intralipid 20%) administered, followed by an infusion. His symptoms (aside from mild agitation) resolved within an hour of cessation of the local anaesthetic and commencement of lipid rescue. The total serum concentration of ropivacaine during the event was 2.1 mg/L compared with a published toxic level of 2.2 mg/L in healthy human volunteers. PMID:27302637

  3. Toxic shock syndrome toxin-1-mediated toxicity inhibited by neutralizing antibodies late in the course of continual in vivo and in vitro exposure.

    PubMed

    Stich, Norbert; Model, Nina; Samstag, Aysen; Gruener, Corina S; Wolf, Hermann M; Eibl, Martha M

    2014-06-01

    Toxic shock syndrome (TSS) results from the host's overwhelming inflammatory response and cytokine storm mainly due to superantigens (SAgs). There is no effective specific therapy. Application of immunoglobulins has been shown to improve the outcome of the disease and to neutralize SAgs both in vivo and in vitro. However, in most experiments that have been performed, antiserum was either pre-incubated with SAg, or both were applied simultaneously. To mirror more closely the clinical situation, we applied a multiple dose (over five days) lethal challenge in a rabbit model. Treatment with toxic shock syndrome toxin 1 (TSST-1) neutralizing antibody was fully protective, even when administered late in the course of the challenge. Kinetic studies on the effect of superantigen toxins are scarce. We performed in vitro kinetic studies by neutralizing the toxin with antibodies at well-defined time points. T-cell activation was determined by assessing T-cell proliferation (3H-thymidine incorporation), determination of IL-2 release in the cell supernatant (ELISA), and IL-2 gene activation (real-time PCR (RT-PCR)). Here we show that T-cell activation occurs continuously. The application of TSST-1 neutralizing antiserum reduced IL-2 and TNFα release into the cell supernatant, even if added at later time points. Interference with the prolonged stimulation of proinflammatory cytokines is likely to be in vivo relevant, as postexposure treatment protected rabbits against the multiple dose lethal SAg challenge. Our results shed new light on the treatment of TSS by specific antibodies even at late stages of exposure. PMID:24887085

  4. Toxic Shock Syndrome Toxin-1-Mediated Toxicity Inhibited by Neutralizing Antibodies Late in the Course of Continual in Vivo and in Vitro Exposure

    PubMed Central

    Stich, Norbert; Model, Nina; Samstag, Aysen; Gruener, Corina S.; Wolf, Hermann M.; Eibl, Martha M.

    2014-01-01

    Toxic shock syndrome (TSS) results from the host’s overwhelming inflammatory response and cytokine storm mainly due to superantigens (SAgs). There is no effective specific therapy. Application of immunoglobulins has been shown to improve the outcome of the disease and to neutralize SAgs both in vivo and in vitro. However, in most experiments that have been performed, antiserum was either pre-incubated with SAg, or both were applied simultaneously. To mirror more closely the clinical situation, we applied a multiple dose (over five days) lethal challenge in a rabbit model. Treatment with toxic shock syndrome toxin 1 (TSST-1) neutralizing antibody was fully protective, even when administered late in the course of the challenge. Kinetic studies on the effect of superantigen toxins are scarce. We performed in vitro kinetic studies by neutralizing the toxin with antibodies at well-defined time points. T-cell activation was determined by assessing T-cell proliferation (3H-thymidine incorporation), determination of IL-2 release in the cell supernatant (ELISA), and IL-2 gene activation (real-time PCR (RT-PCR)). Here we show that T-cell activation occurs continuously. The application of TSST-1 neutralizing antiserum reduced IL-2 and TNFα release into the cell supernatant, even if added at later time points. Interference with the prolonged stimulation of proinflammatory cytokines is likely to be in vivo relevant, as postexposure treatment protected rabbits against the multiple dose lethal SAg challenge. Our results shed new light on the treatment of TSS by specific antibodies even at late stages of exposure. PMID:24887085

  5. 40 CFR 763.84 - General local education agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false General local education agency responsibilities. 763.84 Section 763.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... Transportation and the U.S. Environmental Protection Agency. (h) Consider whether any conflict of interest...

  6. 40 CFR 763.84 - General local education agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false General local education agency responsibilities. 763.84 Section 763.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... Transportation and the U.S. Environmental Protection Agency. (h) Consider whether any conflict of interest...

  7. 40 CFR 763.84 - General local education agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false General local education agency responsibilities. 763.84 Section 763.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... Transportation and the U.S. Environmental Protection Agency. (h) Consider whether any conflict of interest...

  8. 40 CFR 763.84 - General local education agency responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false General local education agency responsibilities. 763.84 Section 763.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... Transportation and the U.S. Environmental Protection Agency. (h) Consider whether any conflict of interest...

  9. Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system

    USGS Publications Warehouse

    Meinertz, J.R.; Schreier, T.M.; Bernardy, J.A.; Franz, J.L.

    2010-01-01

    Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 (mu or u)g/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 (mu or u)g/L and for ET was 248 (mu or u)g/L.

  10. 41 CFR 102-85.200 - Can customer agencies continue occupancy of space or must they relocate at the end of an OA?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Can customer agencies continue occupancy of space or must they relocate at the end of an OA? 102-85.200 Section 102-85.200 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY...

  11. 41 CFR 102-85.200 - Can customer agencies continue occupancy of space or must they relocate at the end of an OA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Can customer agencies continue occupancy of space or must they relocate at the end of an OA? 102-85.200 Section 102-85.200 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY...

  12. 40 CFR 797.1600 - Fish early life stage toxicity test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Fish early life stage toxicity test. 797.1600 Section 797.1600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) ENVIRONMENTAL EFFECTS TESTING GUIDELINES Aquatic Guidelines § 797.1600 Fish early life stage toxicity test....

  13. 40 CFR 80.810 - Who shall register with EPA under the gasoline toxics program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... gasoline toxics program? 80.810 Section 80.810 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics General Information § 80.810 Who shall register with EPA under the gasoline toxics program? (a) Refiners and...

  14. 40 CFR 80.810 - Who shall register with EPA under the gasoline toxics program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... gasoline toxics program? 80.810 Section 80.810 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics General Information § 80.810 Who shall register with EPA under the gasoline toxics program? (a) Refiners and...

  15. 40 CFR 80.1015 - Who is liable for violations under the gasoline toxics program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... gasoline toxics program? 80.1015 Section 80.1015 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1015 Who is liable for violations under the gasoline toxics program? (a) Persons liable...

  16. 40 CFR 80.1015 - Who is liable for violations under the gasoline toxics program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... gasoline toxics program? 80.1015 Section 80.1015 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1015 Who is liable for violations under the gasoline toxics program? (a) Persons liable...

  17. 40 CFR 80.1005 - What acts are prohibited under the gasoline toxics program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... gasoline toxics program? 80.1005 Section 80.1005 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1005 What acts are prohibited under the gasoline toxics program? No person shall:...

  18. 40 CFR 80.810 - Who shall register with EPA under the gasoline toxics program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... gasoline toxics program? 80.810 Section 80.810 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics General Information § 80.810 Who shall register with EPA under the gasoline toxics program? (a) Refiners and...

  19. 40 CFR 80.1015 - Who is liable for violations under the gasoline toxics program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... gasoline toxics program? 80.1015 Section 80.1015 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1015 Who is liable for violations under the gasoline toxics program? (a) Persons liable...

  20. 40 CFR 80.1005 - What acts are prohibited under the gasoline toxics program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... gasoline toxics program? 80.1005 Section 80.1005 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1005 What acts are prohibited under the gasoline toxics program? No person shall:...

  1. 40 CFR 80.1005 - What acts are prohibited under the gasoline toxics program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... gasoline toxics program? 80.1005 Section 80.1005 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1005 What acts are prohibited under the gasoline toxics program? No person shall:...

  2. 40 CFR 80.1005 - What acts are prohibited under the gasoline toxics program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... gasoline toxics program? 80.1005 Section 80.1005 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1005 What acts are prohibited under the gasoline toxics program? No person shall:...

  3. 40 CFR 80.810 - Who shall register with EPA under the gasoline toxics program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... gasoline toxics program? 80.810 Section 80.810 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics General Information § 80.810 Who shall register with EPA under the gasoline toxics program? (a) Refiners and...

  4. 40 CFR 80.1015 - Who is liable for violations under the gasoline toxics program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... gasoline toxics program? 80.1015 Section 80.1015 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1015 Who is liable for violations under the gasoline toxics program? (a) Persons liable...

  5. 40 CFR 80.810 - Who shall register with EPA under the gasoline toxics program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... gasoline toxics program? 80.810 Section 80.810 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics General Information § 80.810 Who shall register with EPA under the gasoline toxics program? (a) Refiners and...

  6. 40 CFR 80.1015 - Who is liable for violations under the gasoline toxics program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... gasoline toxics program? 80.1015 Section 80.1015 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1015 Who is liable for violations under the gasoline toxics program? (a) Persons liable...

  7. 40 CFR 80.1005 - What acts are prohibited under the gasoline toxics program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... gasoline toxics program? 80.1005 Section 80.1005 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Toxics Violation Provisions § 80.1005 What acts are prohibited under the gasoline toxics program? No person shall:...

  8. 40 CFR 799.9346 - TSCA 90-day inhalation toxicity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA 90-day inhalation toxicity. 799.9346 Section 799.9346 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines...

  9. TOXICITY AND METABOLISM STUDIES WITH EPA (ENVIRONMENTAL PROTECTION AGENCY) PRIORITY POLLUTANTS AND RELATED CHEMICALS IN FRESHWATER ORGANISMS

    EPA Science Inventory

    Twenty-two chemicals from the EPA priority pollutant list were studied for their acute and/or chronic toxicity to selected freshwater organisms. Freshwater species tested included the fathead minnow (Pimephales promelas), rainbow trout (Salmo gairdneri), bluegill sunfish (Lepomis...

  10. Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study.

    PubMed

    Beck, Nancy B; Becker, Richard A; Erraguntla, Neeraja; Farland, William H; Grant, Roberta L; Gray, George; Kirman, Christopher; LaKind, Judy S; Jeffrey Lewis, R; Nance, Patricia; Pottenger, Lynn H; Santos, Susan L; Shirley, Stephanie; Simon, Ted; Dourson, Michael L

    2016-01-01

    Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs for assessing potential risks associated with site- or use-specific exposures. The resulting point estimates are often used by risk managers for regulatory decision-making, including standard setting, determination of emission controls, and mitigation of exposures to chemical substances. Risk managers, as well as stakeholders (interested and affected parties), often have limited information regarding assumptions and uncertainty factors in numerical estimates of both hazards and risks. Further, the use of different approaches for addressing uncertainty, which vary in transparency, can lead to a lack of confidence in the scientific underpinning of regulatory decision-making. The overarching goal of this paper, which was developed from an invited participant workshop, is to offer five approaches for presenting toxicity values in a transparent manner in order to improve the understanding, consideration, and informed use of uncertainty by risk assessors, risk managers, and stakeholders. The five approaches for improving the presentation and communication of uncertainty are described using U.S. Environmental Protection Agency's (EPA's) Integrated Risk Information System (IRIS) as a case study. These approaches will ensure transparency in the documentation, development, and use of toxicity values at EPA, the Agency for Toxic Substances and Disease Registry (ATSDR), and other similar assessment programs in the public and private sector. Further empirical testing will help to inform the approaches that will work best for specific audiences and situations. PMID:26827183

  11. 40 CFR 129.6 - Adjustment of effluent standard for presence of toxic pollutant in the intake water.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... presence of toxic pollutant in the intake water. 129.6 Section 129.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS TOXIC POLLUTANT EFFLUENT STANDARDS Toxic Pollutant Effluent Standards and Prohibitions § 129.6 Adjustment of effluent standard for presence of toxic...

  12. Remote Continuous Wave and Pulsed Laser Raman Detection of Chemical Warfare Agents Simulants and Toxic Industrial Compounds

    NASA Astrophysics Data System (ADS)

    Ortiz-Rivera, William; Pacheco-Londoño, Leonardo C.; Hernández-Rivera, Samuel P.

    2010-09-01

    This study describes the design, assembly, testing and comparison of two Remote Raman Spectroscopy (RRS) systems intended for standoff detection of hazardous chemical liquids. Raman spectra of Chemical Warfare Agents Simulants (CWAS) and Toxic Industrial Compounds (TIC) were measured in the laboratory at a 6.6 m source-target distance using continuous wave (CW) laser detection. Standoff distances for pulsed measurements were 35 m for dimethyl methylphosphonate (DMMP) detection and 60, 90 and 140 m for cyclohexane detection. The prototype systems consisted of a Raman spectrometer equipped with a CCD detector (for CW measurements) and an I-CCD camera with time-gated electronics (for pulsed laser measurements), a reflecting telescope, a fiber optic assembly, a single-line CW laser source (514.5, 488.0, 351.1 and 363.8 nm) and a frequency-doubled single frequency Nd:YAG 532 nm laser (5 ns pulses at 10 Hz). The telescope was coupled to the spectrograph using an optical fiber, and filters were used to reject laser radiation and Rayleigh scattering. Two quartz convex lenses were used to collimate the light from the telescope from which the telescope-focusing eyepiece was removed, and direct it to the fiber optic assembly. To test the standoff sensing system, the Raman Telescope was used in the detection of liquid TIC: benzene, chlorobenzene, toluene, carbon tetrachloride, cyclohexane and carbon disulfide. Other compounds studied were CWAS: dimethylmethyl phosphonate, 2-chloroethyl ethyl sulfide and 2-(butylamino)-ethanethiol. Relative Raman scattering cross sections of liquid CWAS were measured using single-line sources at 532.0, 488.0, 363.8 and 351.1 nm. Samples were placed in glass and quartz vials at the standoff distances from the telescope for the Remote Raman measurements. The mass of DMMP present in water solutions was also quantified as part of the system performance tests.

  13. 40 CFR Table 2 of Subpart Ec to... - Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Toxic Equivalency Factors 2 Table 2 of Subpart Ec to Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Ec to Part 60—Toxic Equivalency Factors Dioxin/furan congener Toxic equivalency factor...

  14. 40 CFR Table 2 of Subpart Ec to... - Toxic Equivalency Factors

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Toxic Equivalency Factors 2 Table 2 of Subpart Ec to Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Ec to Part 60—Toxic Equivalency Factors Dioxin/furan congener Toxic equivalency factor...

  15. 40 CFR Table 6 to Subpart Hhhhhhh... - Toxic Equivalency Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 15 2014-07-01 2014-07-01 false Toxic Equivalency Factors 6 Table 6 to Subpart HHHHHHH of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards...

  16. 40 CFR Table 6 to Subpart Hhhhhhh... - Toxic Equivalency Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 15 2013-07-01 2013-07-01 false Toxic Equivalency Factors 6 Table 6 to Subpart HHHHHHH of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards...

  17. AQUIRE--AQUATIC TOXICITY INFORMATION RETRIEVAL DATA BASE (MAGNETIC TAPE)

    EPA Science Inventory

    The AQUlRE -- Aquatic Toxicity Information Retrieval -- data base was established in 1981 by the United States Environmental Protection Agency (U.S. EPA), Office of Pesticides and Toxic Substances. AQUlRE continues to be updated and maintained atthe U.S. EPA Environmental Researc...

  18. Update to agency for toxic substances and disease registry 2012 report on assessment of biota exposure to mercury originating from Savannah River Site.

    SciTech Connect

    Kuhne, W.

    2015-08-10

    The purpose of this report is to 1) update previous Savannah River National Laboratory (SRNL) assessment reports (Kvartek et al. 1994 and Halverson et al. 2008) on the fate of mercury in the Savannah River Site (SRS) environment and 2) address comments and recommendations from the review of SRS by the Agency for Toxic Substances and Disease Registry (ATSDR) concerning the evaluation of exposures to contaminants in biota originating from the SRS. The ATSDR reviewed and evaluated data from SRS, South Carolina Department of Health & Environmental Control (SCDHEC) and the Georgia Department of Natural Resources (GDNR) concerning the non-radioactive contaminant mercury. This report will provide a response and update to conclusions and recommendations made by the ATSDR.

  19. Capacity building in Developing Countries: a challenge ahead for the European Space Agency to continue its successful experience to date

    NASA Astrophysics Data System (ADS)

    Fea, M.

    The European Space Agency (ESA) has built a long tradition and a large experience in the domain of education, training and capacity building throughout its space programmes. As an example, the ESA Science Programme dedicates 1% of its budget to these activities. One of the key reasons for it is the need of closing the loop along the chain from the provider to the user, that is to say between the space and the users elements. In fact, besides the obvious need for technology development, there is actually not very much justification in the long term for a space programme if the user communities are not able to make good use of programme outputs and provide feedback and proper requirements to space agencies. The case of ESA Earth Observation programmes is described to illustrate these considerations, as a way to also implement the European Space Policy and UNISPACE III recommendations. Since its foundation in 1975 and the implementation of its EO programme with the launch of Meteosat-1 in 1977 and the birth of the Earthnet Programme Office in 1978, the European Space Agency is very active in the field of capacity building in developing countries. That is performed through both ESA's specific projects and international co-operation activities. In the latter domain, ESA enjoys a long-standing collaboration with many entities, such as the Committee of Earth Observation Satellites (CEOS), and organisations, such as WMO, UN and its specialised agencies (FAO, UNESCO, UNEP, and so on). In that respect, the Agency is an active member of the CEOS Working Group on Education (WGEdu) and of the World Summit for Sustainable Development Follow-Up (WSSD) Module 1 group dedicated to education, training and capacity building. The overall ESA strategy targets various citizen communities and takes into account the fact that today's young generations will become tomorrow's professionals and decision makers. ESA's activities in this domain are in particular based on an end-to-end concept

  20. 40 CFR 799.9305 - TSCA Repeated dose 28-day oral toxicity study in rodents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA Repeated dose 28-day oral toxicity study in rodents. 799.9305 Section 799.9305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS Health...

  1. 40 CFR 798.6560 - Subchronic delayed neuro-toxicity of organophosphorus substances.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Subchronic delayed neuro-toxicity of organophosphorus substances. 798.6560 Section 798.6560 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Neurotoxicity § 798.6560 Subchronic...

  2. 40 CFR 798.6560 - Subchronic delayed neuro-toxicity of organophosphorus substances.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Subchronic delayed neuro-toxicity of organophosphorus substances. 798.6560 Section 798.6560 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Neurotoxicity § 798.6560 Subchronic...

  3. Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously

    PubMed Central

    WEHLER, THOMAS C.; CAO, YANG; GALLE, PETER R.; THEOBALD, MATTHIAS; MOEHLER, MARKUS; SCHIMANSKI, CARL C.

    2012-01-01

    The use of anticancer drugs in palliative settings is often limited by their severe toxic effects. In gastrointestinal carcinomas the 5-fluorouracil-based palliative regimen FOLFOX-4 is often preferred to the equally effective, but more convenient oral capecitabine-based regimen XELOX. This preference is mainly based on the fact that the highly effective oral agent capecitabine induces hand-foot syndrome (HFS). In this study, we investigated whether the continuous administration of skin prophylaxis (10% urea, panthenol, bisabolol, vitamin A, C and E) is capable of protecting against capecitabine-induced HFS and allowing a more convenient oral therapeutic option. In this retrospective analysis, the toxicity profiles, according to NCI CTCAE 3.0 criteria, of 54 patients with gastrointestinal cancer who received either XELOX (34 patients) or FOLFOX-4 (20 patients) were compared using Fisher tests. The treatment protocols that were compared, herein, did not differ significantly in the majority of the analyzed items, with the exception of increased nausea (XELOX-70), fatigue (XELOX-130) and tumor pain (XELOX-70 and XELOX-130). No significant differences were observed among the various groups with regard to emesis, diarrhea, mucositis, exanthema, alopecia, loss of weight and the incidence of infections. In particular, no significant differences in toxicity levels occurred in terms of dose, and HFS was limited if skin prophylaxis was performed continuously. XELOX-based palliative regimens provide an equally effective and comparably toxic therapeutic alternative to FOLFOX-4 if HFS prophylaxis is performed continuously. Since the oral administration of capecitabine is a more convenient method of application, it provides patients with a quality of life-preserving therapeutic alternative. PMID:22783416

  4. Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously.

    PubMed

    Wehler, Thomas C; Cao, Yang; Galle, Peter R; Theobald, Matthias; Moehler, Markus; Schimanski, Carl C

    2012-06-01

    The use of anticancer drugs in palliative settings is often limited by their severe toxic effects. In gastrointestinal carcinomas the 5-fluorouracil-based palliative regimen FOLFOX-4 is often preferred to the equally effective, but more convenient oral capecitabine-based regimen XELOX. This preference is mainly based on the fact that the highly effective oral agent capecitabine induces hand-foot syndrome (HFS). In this study, we investigated whether the continuous administration of skin prophylaxis (10% urea, panthenol, bisabolol, vitamin A, C and E) is capable of protecting against capecitabine-induced HFS and allowing a more convenient oral therapeutic option. In this retrospective analysis, the toxicity profiles, according to NCI CTCAE 3.0 criteria, of 54 patients with gastrointestinal cancer who received either XELOX (34 patients) or FOLFOX-4 (20 patients) were compared using Fisher tests. The treatment protocols that were compared, herein, did not differ significantly in the majority of the analyzed items, with the exception of increased nausea (XELOX-70), fatigue (XELOX-130) and tumor pain (XELOX-70 and XELOX-130). No significant differences were observed among the various groups with regard to emesis, diarrhea, mucositis, exanthema, alopecia, loss of weight and the incidence of infections. In particular, no significant differences in toxicity levels occurred in terms of dose, and HFS was limited if skin prophylaxis was performed continuously. XELOX-based palliative regimens provide an equally effective and comparably toxic therapeutic alternative to FOLFOX-4 if HFS prophylaxis is performed continuously. Since the oral administration of capecitabine is a more convenient method of application, it provides patients with a quality of life-preserving therapeutic alternative. PMID:22783416

  5. Assessing acute toxicity of effluent from a textile industry and nearby river waters using sulfur-oxidizing bacteria in continuous mode.

    PubMed

    Gurung, Anup; Hassan, Sedky H A; Oh, Sang-Eun

    2011-10-01

    Bioassays are becoming an important tool for assessing the toxicity of complex mixtures of substances in aquatic environments in which Daphnia magna is routinely used as a test organism. Bioassays outweigh physicochemical analyses and are valuable in the decision-making process pertaining to the final discharge of effluents from wastewater treatment plants as they measure the total effect of the discharge which is ecologically relevant. In this study, the aquatic toxicity of a textile plant effluent and river water downstream from the plant were evaluated with sulfur-oxidizing bacterial biosensors in continuous mode. Collected samples were analysed for different physicochemical parameters and 1,4-dioxane was detected in the effluent. The effluent contained a relatively high chemical oxygen demand of 60 mg L(-1), which exceeded the limit set by the Korean government for industrial effluent discharges. Results showed that both the effluent and river waters were toxic to sulfur-oxidizing bacteria. These results show the importance of incorporating bioassays to detect toxicity in wastewater effluents for the sustainable management of water resources. PMID:22329151

  6. Extended continuous infusion low-dose recombinant interleukin-2 in advanced cancer: prolonged immunomodulation without significant toxicity.

    PubMed

    Caligiuri, M A; Murray, C; Soiffer, R J; Klumpp, T R; Seiden, M; Cochran, K; Cameron, C; Ish, C; Buchanan, L; Perillo, D

    1991-12-01

    In previous clinical trials, recombinant interleukin-2 (rIL-2) has been infused at high doses over short periods of time to generate lymphokine-activated killer (LAK) cells in vivo. These trials have been limited by severe toxicities, and the immunologic effects of rIL-2 have been transient. The present study was designed to assess the toxicity and immunologic effects of prolonged administration of low doses of rIL-2. In this phase I study, patients with advanced cancer were scheduled to receive intravenous (IV) infusion of rIL-2 without interruption for 3 months in an outpatient setting. Twenty-one patients received rIL-2 at doses ranging from 0.5 x 10(5) to 6.0 x 10(5) U/m2/d. Treatment was extremely well tolerated, and no patient experienced grade 3 or grade 4 toxicity. The lowest dose level (0.5 x 10(5) U/m2/d) did not have demonstrable immunologic activity. At doses of 1.5 x 10(5) and 4.5 x 10(5) U/m2/d, rIL-2 infusion resulted in the specific expansion of natural-killer (NK) cells (sixfold and ninefold increases, respectively, at these two dose levels) without any changes in B cells, T cells, neutrophils, or monocytes. Grade 2 toxicity was observed at the dose of 6.0 x 10(5) U/m2/d, as three patients required interruption of therapy and two patients who completed therapy developed transient hypothyroidism. In patients with increased NK cells, enhancement of non-major histocompatibility complex (MHC)-restricted cytotoxicity and increased generation of LAK cells in vitro were also demonstrated. Therapy with low-dose rIL-2 can be given safely in an uninterrupted fashion for prolonged periods of time in an outpatient setting. This results in selective expansion of NK cells in vivo with minimal toxicity. Further investigation of this schedule for immunomodulation in vivo should be pursued in phase II studies of both malignant and immunodeficient disease states. PMID:1960552

  7. 41 CFR 102-85.205 - What happens if a customer agency continues occupancy after the expiration of an OA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... assignments. However, provisions are necessary to cover the GSA and customer relationship if an OA expires... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What happens if a... Contracts and Property Management Federal Property Management Regulations System (Continued)...

  8. 41 CFR 102-85.205 - What happens if a customer agency continues occupancy after the expiration of an OA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... assignments. However, provisions are necessary to cover the GSA and customer relationship if an OA expires... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What happens if a... Contracts and Property Management Federal Property Management Regulations System (Continued)...

  9. A microfluidic device for the continuous culture and analysis of Caenorhabditis elegans in a toxic aqueous environment

    NASA Astrophysics Data System (ADS)

    Jung, Jaehoon; Nakajima, Masahiro; Tajima, Hirotaka; Huang, Qiang; Fukuda, Toshio

    2013-08-01

    The nematode Caenorhabditis elegans (C. elegans) receives attention as a bioindicator, and the C. elegans condition has been recently analyzed using microfluidic devices equipped with an imaging system. To establish a method without an imaging system, we have proposed a novel microfluidic device with which to analyze the condition of C. elegans from the capacitance change using a pair of micro-electrodes. The device was designed to culture C. elegans, to expose C. elegans to an external stimulus, such as a chemical or toxicant, and to measure the capacitance change which indicates the condition of C. elegans. In this study, to demonstrate the capability of our device in a toxic aqueous environment, the device was applied to examine the effect of cadmium on C. elegans. Thirty L4 larval stage C. elegans were divided into three groups. One group was a control group and the other groups were exposed to cadmium solutions with concentrations of 5% and 10% LC50 for 24 h. The capacitance change and the body volume of C. elegans as a reference were measured four times and we confirmed the correlation between them. It shows that our device can analyze the condition of C. elegans without an imaging system.

  10. EPN Continuous Cumulative Solution - Single Analysis Centers and Combination -,Heinz Habrich, Federal Agency for Cartography and Geodesy, Frankfurt M., Germany

    NASA Astrophysics Data System (ADS)

    Habrich, H.

    2009-12-01

    -specific generation of CSs, which did not exist so far and may contribute to improve the EPN weekly combination. Other innovations are the continuous update of the CSs at every week and the usage of the FODITS tool. With FODITS not only linear trends but also periodic signals in coordinate time series will be modeled. The discussion of the coordinate reference epoch figured out to be an important aspect for coordinate comparison issues. Where the so-called “epoch of minimum variance” has been recommended for release of a single CS, it is not suitable for comparisons of solutions from various analysis centers, because it may be different for each analysis center. Such comparisons require synchronized reference epochs even in case of commonly applied a-priori information for station discontinuities during the processing. The results include an investigation of LAC-specific CSs and of residuals from direct comparisons as well as Helmert transformations between EPN, ITRF and other solutions. The impact of reference epoch selection on the compared coordinates will be shown. The demonstrated strategy for generating CSs and comparison of synchronized solution numbers is of general interest with respect to ongoing re-processing initiatives and future realizations of terrestrial reference frames.

  11. How To Minimize Toxic Exposure to Pyridine during Continuous Infusion of Ceftazidime in Patients with Cystic Fibrosis?

    PubMed Central

    Amin, A.; Dupont, C.; Abely, M.; Desmazes-Dufeu, N.; Dubus, J. C.; Jouani, B.-L.; Merlette, C.; Nové-Josserand, R.; Pages, J.; Panzo, R.; Vidal, F.; Voge, F.; Hubert, D.

    2014-01-01

    Ceftazidime is particularly efficient against Pseudomonas aeruginosa in cystic fibrosis patients. Thus, the spontaneous production of pyridine, which is a toxic product, raises some concern. Our aim was to examine the kinetics of degradation of ceftazidime in portable infusion pumps either at 4°C, 22°C, or 33°C and to propose some recommendations in order to reduce the pyridine exposure. Two administration models were studied in vitro. In model 1, we administered 12 g of ceftazidime infused over 23 h (once-daily infusion) compared to 6 g infused over 11.5 h in model 2 (twice-daily regimen). Samples were collected at 0 h and then every 4 and 2 h after the shaping of portable infusion pumps in models 1 and 2, respectively. Both ceftazidime and pyridine were analyzed using an ultraviolet high-performance liquid chromatograph. Production of pyridine is highly depending on the temperature. The in situ production of pyridine per day of treatment decreases at a ratio close to 1/6 and 1/3 between 33°C and 4°C in models 1 and 2, respectively. Regardless of the conditions, the production of pyridine is significantly lower in model 2, whereas the total delivery amount of ceftazidime is significantly higher at 4°C and 33°C compared to that in model 1. According to a the precautionary principle, these findings lead to three major recommendations: (i) exposing a solution of ceftazidime to over 22°C should be strictly avoided, (ii) a divided dose of 6 g over 11.5 h instead of a once-daily administration is preferred, and (iii) infusion should be administered immediately after reconstitution. PMID:24614367

  12. Chronic toxicity of hydrogen peroxide to Daphnia magna in a continuous exposure, flow-through test system

    USGS Publications Warehouse

    Meinertz, J.R.; Greseth, Shari L.; Gaikowski, M.P.; Schmidt, L.J.

    2008-01-01

    A flow-through, continuous exposure test system was developed to expose Daphnia magna to an unstable compound. 35% Perox-Aid?? is a specially formulated hydrogen peroxide (a highly oxidative chemical) product approved for use in U.S. aquaculture and therefore has the potential to be released from aquaculture facilities and pose a risk to aquatic invertebrates. The study objective was to assess the effects of 35% Perox-Aid?? on an aquatic invertebrate by evaluating the survival, growth, production, and gender ratio of progeny from a representative aquatic invertebrate continuously exposed to 35% Perox-Aid??. The study design consisted of 6 treatment groups (10 test chambers each) with target hydrogen peroxide concentrations of 0.0, 0.32, 0.63, 1.25, 2.5, and 5.0??mg L- 1. The study was initiated with < 24-h-old Daphnia (1 daphnid per chamber) that were exposed to hydrogen peroxide for 21??days. Hydrogen peroxide concentrations ??? 1.25??mg L- 1 had no significant effect on Daphnia time to death compared to controls and no significant effect on the time to first brood production and the number of broods produced. Concentrations ??? 0.63??mg L- 1 had no significant effect on the total number of young produced. Concentrations ??? 0.32??mg L- 1 had a negative effect on Daphnia growth. Hydrogen peroxide had no significant effect on the gender ratio of young produced. All second generation Daphnia were female. A continuous discharge of hydrogen peroxide into aquatic ecosystems is not likely to affect cladocerans if the concentration is maintained at ??? 0.63??mg L- 1 for less than 21??days.

  13. Toxicity of silver to two freshwater algae, Chlamydomonas reinhardtii and Pseudokirchneriella sub-capitata, grown under continuous culture conditions: influence of thiosulphate.

    PubMed

    Hiriart-Baer, Véronique P; Fortin, Claude; Lee, Dae-Young; Campbell, Peter G C

    2006-06-15

    In a test of the biotic ligand model (BLM), the uptake and toxicity of silver, in the absence or presence of the inorganic ligand, thiosulphate, were assessed for two freshwater green algae, Chlamydomonas reinhardtii and Pseudokirchneriella sub-capitata, using turbidostat continuous cultures. In the initial experiments, run in the absence of thiosulphate, the influent Ag concentration was varied from 0 to 75 nM in steps; for each influent concentration, silver uptake was calculated and the algal growth rate was determined. Silver uptake rates at low Ag concentrations were similar for both algae (e.g., 14-19 nmolm(-2)h(-1), for influent Ag(+) concentrations of approximately 9 nM) but at higher exposures uptake by P. sub-capitata exceeded that of C. reinhardtii. Despite this higher uptake rate, in the absence of thiosulphate P. sub-capitata was not more sensitive to free silver; 50% growth inhibition was reached at influent free Ag(+) concentrations of 15+/-7 and 22+/-13 nM for C. reinhardtii and P. sub-capitata, respectively. In the second series of experiments, the free Ag(+) concentration was held constant ( approximately 9 nM in the influent; 2-3 nM in the effluent) while the concentration of the silver thiosulphate complex, AgS(2)O(3)(-), was increased from 9 to 90 nM in steps. Under such conditions, the BLM would predict that silver uptake and toxicity should remain constant. On the contrary, both silver uptake and silver toxicity increased, indicating that the anionic silver thiosulphate complex enters the algal cells via a membrane-bound sulphate transporter and contributes to uptake and toxicity. However, for both algae there were indications that silver assimilated in this manner was somewhat less toxic to the algal cell than silver that entered via cation transport only. Physiological indicators of stress revealed possible different intracellular targets for these two freshwater algae, proteins and enzymes for C. reinhardtii and the photosynthetic

  14. European Chemicals Agency dossier submissions as an experimental data source: refinement of a fish toxicity model for predicting acute LC50 values.

    PubMed

    Austin, Thomas; Denoyelle, Marieva; Chaudry, Amjad; Stradling, Sam; Eadsforth, Charles

    2015-02-01

    As a result of the stringent data requirements of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation, a vast amount of ecotoxicological data has become available through the dissemination portal of the European Chemicals Agency (ECHA). As of April 2014, the database contained 12,439 unique substances from 47,909 dossiers. This vast database could be used to refine existing, or to create new, non-testing methods, such as quantitative structure-activity relationships (QSARs). Acute fish toxicity data were mined from the ECHA database using the eChemPortal; after filtering for single organic substances, 1159 experimental data points remained, representing 564 compounds. To evaluate the quality and accessibility of this data, the authors used the data to refine and improve an existing QSAR. The reliability of the data submitted to the ECHA database, as well as the effectiveness of the Klimisch scoring system, were assessed by comparing the refined QSAR with established QSAR benchmarks. The model developed meets all Organisation for Economic Co-operation and Development principles, has strong internal (leave-one-out internally cross-validated correlation coefficient [Q(2)(LOO)] = 0.91) and external (external coefficient of determination (predicted vs experimental [test set])) validation statistics, and can provide reliable fish median lethal concentration (LC50) predictions for non-polar narcotics. Although some issues with dossier misinformation were discovered, it was found that the ECHA dissemination portal is a valuable and reliable data source. When queried using the eChemPortal, chemical dossiers containing reliable data could be found quickly. The ECHA dissemination portal holds great potential for future QSAR development and improvement, such as updating QSARs within the Ecological Structure-Activity Relationships (ECOSAR) program. PMID:25470737

  15. Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system

    USGS Publications Warehouse

    Meinertz, J.R.; Schreier, T.M.; Bernardy, J.A.

    2011-01-01

    Approval of a new animal drug application for AQUAMYCIN 100?? (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ETs impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on a chronically exposed aquatic invertebrate organism. A major step to fulfilling the environmental assessment was completed after conducting a comprehensive study continuously exposing Daphnia magna to ET for 21 days. Results indicated that the no observable effect concentration for ET was 179 ??g/L. ?? 2011 Springer Science+Business Media, LLC (outside the USA).

  16. Continuous-flow leaching in a rotating coiled column for studies on the mobility of toxic elements in dust samples collected near a metallurgic plant.

    PubMed

    Fedotov, Petr S; Ermolin, Mikhail S; Ivaneev, Alexandr I; Fedyunina, Natalia N; Karandashev, Vasily K; Tatsy, Yury G

    2016-03-01

    Continuous-flow (dynamic) leaching in a rotating coiled column has been applied to studies on the mobility of Zn, Cd, Cu, Pb, Ni, Sb, As, S, and other potentially toxic elements in atmospherically deposited dust samples collected near a large copper smelter (Chelyabinsk region, Russia). Water and simulated "acid rain" (pH 4) were used as eluents. The technique enables not only the fast and efficient leaching of elements but as well time-resolved studies on the mobilization of heavy metals, sulphur, and arsenic in environmentally relevant forms to be made. It is shown that up to 1.5, 4.1, 1.9, 11.1, and 46.1% of Pb, As, Cu, Zn, and S, correspondingly, can be easily mobilized by water. Taking into consideration that the total concentrations of these elements in the samples under investigation are surprisingly high and vary in the range from 2.7 g/kg (for arsenic) to 15.5 g/kg (for sulphur), the environmental impact of the dust may be dramatic. The simulated acid rain results in somewhat higher recoveries of elements, except Cu and Pb. The proposed approach and the data obtained can very useful for the risk assessment related to the mobility of potentially toxic elements and their inclusion in the biogeochemical cycle. PMID:26741541

  17. 40 CFR 725.232 - Activities subject to the jurisdiction of other Federal programs or agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Activities subject to the jurisdiction of other Federal programs or agencies. 725.232 Section 725.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND...

  18. 40 CFR 725.232 - Activities subject to the jurisdiction of other Federal programs or agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Activities subject to the jurisdiction of other Federal programs or agencies. 725.232 Section 725.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND...

  19. 40 CFR 725.232 - Activities subject to the jurisdiction of other Federal programs or agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Activities subject to the jurisdiction of other Federal programs or agencies. 725.232 Section 725.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND...

  20. Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014.

    PubMed

    Solecki, Roland; Rauch, Martina; Gall, Andrea; Buschmann, Jochen; Clark, Ruth; Fuchs, Antje; Kan, Haidong; Heinrich, Verena; Kellner, Rupert; Knudsen, Thomas B; Li, Weihua; Makris, Susan L; Ooshima, Yojiro; Paumgartten, Francisco; Piersma, Aldert H; Schönfelder, Gilbert; Oelgeschläger, Michael; Schaefer, Christof; Shiota, Kohei; Ulbrich, Beate; Ding, Xuncheng; Chahoud, Ibrahim

    2015-11-01

    This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes. PMID:26073002

  1. 40 CFR Table 3 to Subpart X of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Subpart X of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Standards For Hazardous Air Pollutants From Secondary Lead Smelting Pt. 63, Subpt. X, Table 3 Table 3 to Subpart X of Part 63—Toxic Equivalency Factors Dioxin/furan congener Toxic equivalency factor...

  2. 40 CFR Table 3 to Subpart X of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Subpart X of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Standards For Hazardous Air Pollutants From Secondary Lead Smelting Pt. 63, Subpt. X, Table 3 Table 3 to Subpart X of Part 63—Toxic Equivalency Factors Dioxin/furan congener Toxic equivalency factor...

  3. 40 CFR Table 5 to Subpart Mmmm of... - Model Rule-Toxic Equivalency Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Model Rule-Toxic Equivalency Factors 5 Table 5 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Subpart MMMM of Part 60—Model Rule—Toxic Equivalency Factors Dioxin/furan isomer Toxicequivalency factor...

  4. 40 CFR Table 4 to Subpart Dddd of... - Model Rule-Toxic Equivalency Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Model Rule-Toxic Equivalency Factors 4 Table 4 to Subpart DDDD of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Table 4 to Subpart DDDD of Part 60—Model Rule—Toxic Equivalency Factors Dioxin/furan isomer...

  5. 40 CFR Table 4 to Subpart Dddd of... - Model Rule-Toxic Equivalency Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Model Rule-Toxic Equivalency Factors 4 Table 4 to Subpart DDDD of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Table 4 to Subpart DDDD of Part 60—Model Rule—Toxic Equivalency Factors Dioxin/furan isomer...

  6. 40 CFR Table 5 to Subpart Mmmm of... - Model Rule-Toxic Equivalency Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Model Rule-Toxic Equivalency Factors 5 Table 5 to Subpart MMMM of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Subpart MMMM of Part 60—Model Rule—Toxic Equivalency Factors Dioxin/furan isomer Toxicequivalency factor...

  7. 40 CFR Table 2 to Subpart Ttttt of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 14 2011-07-01 2011-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart TTTTT of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... congener Toxic equivalency factor 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1...

  8. 40 CFR Table 2 to Subpart Hhh of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Toxic equivalency factor 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1 1,2,3,7,8-pentachlorinated...

  9. 40 CFR Table 2 to Subpart Ttttt of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 14 2010-07-01 2010-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart TTTTT of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... congener Toxic equivalency factor 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1...

  10. 40 CFR Appendix A to Part 68 - Table of Toxic Endpoints

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Table of Toxic Endpoints A Appendix A to Part 68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Endpoints CAS No. Chemical name Toxic endpoint (mg/L) 107-02-8 Acrolein 0.0011 107-13-1 Acrylonitrile...

  11. 40 CFR Appendix A to Part 68 - Table of Toxic Endpoints

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Table of Toxic Endpoints A Appendix A to Part 68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Endpoints CAS No. Chemical name Toxic endpoint (mg/L) 107-02-8 Acrolein 0.0011 107-13-1 Acrylonitrile...

  12. 40 CFR Appendix A to Part 68 - Table of Toxic Endpoints

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Table of Toxic Endpoints A Appendix A to Part 68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Endpoints CAS No. Chemical name Toxic endpoint (mg/L) 107-02-8 Acrolein 0.0011 107-13-1 Acrylonitrile...

  13. 40 CFR Appendix A to Part 68 - Table of Toxic Endpoints

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Table of Toxic Endpoints A Appendix A to Part 68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Endpoints CAS No. Chemical name Toxic endpoint (mg/L) 107-02-8 Acrolein 0.0011 107-13-1 Acrylonitrile...

  14. 20 CFR 411.582 - Can a State VR agency receive payment under the cost reimbursement payment system if a continuous...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...? Yes. If a State VR agency provides services to a beneficiary under 34 CFR part 361, and elects payment... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Can a State VR agency receive payment under... Systems § 411.582 Can a State VR agency receive payment under the cost reimbursement payment system if...

  15. 20 CFR 411.582 - Can a State VR agency receive payment under the cost reimbursement payment system if a continuous...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...? Yes. If a State VR agency provides services to a beneficiary under 34 CFR part 361, and elects payment... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Can a State VR agency receive payment under... Systems § 411.582 Can a State VR agency receive payment under the cost reimbursement payment system if...

  16. 20 CFR 411.582 - Can a State VR agency receive payment under the cost reimbursement payment system if a continuous...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...? Yes. If a State VR agency provides services to a beneficiary under 34 CFR part 361, and elects payment... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Can a State VR agency receive payment under... Systems § 411.582 Can a State VR agency receive payment under the cost reimbursement payment system if...

  17. 20 CFR 411.582 - Can a State VR agency receive payment under the cost reimbursement payment system if a continuous...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...? Yes. If a State VR agency provides services to a beneficiary under 34 CFR part 361, and elects payment... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Can a State VR agency receive payment under... Systems § 411.582 Can a State VR agency receive payment under the cost reimbursement payment system if...

  18. Continuous infusion or subcutaneous injection of granulocyte-macrophage colony-stimulating factor: increased efficacy and reduced toxicity when given subcutaneously.

    PubMed Central

    Honkoop, A. H.; Hoekman, K.; Wagstaff, J.; van Groeningen, C. J.; Vermorken, J. B.; Boven, E.; Pinedo, H. M.

    1996-01-01

    Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a haematopoietic growth factor with a wide variety of applications in the clinic. In early phase I studies the continuous intravenous (c.i.) route of administration was often used. Later it was shown that subcutaneous (s.c.) administration was also effective. The optimal route of administration remains, however, poorly defined, and no studies have made a direct comparison between these two routes of administration. We treated patients with advanced breast cancer with moderately high-dose doxorubicin and cylophosphamide and GM-CSF. The first 14 patients received GM-CSF by c.i, while subsequently 47 patients received it s.c. Comparison between the two groups showed that c.i. GM-CSF was more toxic in several respects. There was a higher need for erythrocyte and platelet transfusions and a significant deterioration in the performance status. This study indicates that subcutaneous GM-CSF is the preferred route of administration. Randomised trials are, however, needed to confirm these conclusions. PMID:8855987

  19. 40 CFR 125.66 - Toxics control program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Toxics control program. 125.66 Section 125.66 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS CRITERIA AND STANDARDS FOR THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Criteria for Modifying the Secondary Treatment Requirements Under Section...

  20. 40 CFR 79.62 - Subchronic toxicity study with specific health effect assessments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Subchronic toxicity study with specific health effect assessments. 79.62 Section 79.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Testing Requirements for Registration § 79.62 Subchronic...

  1. 40 CFR 268.34 - Waste specific prohibitions-toxicity characteristic metal wastes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Waste specific prohibitions-toxicity characteristic metal wastes. 268.34 Section 268.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Prohibitions on Land Disposal § 268.34 Waste specific...

  2. 40 CFR Table 2 to Subpart Hhh of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for...

  3. 40 CFR Table 3 to Subpart III of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Toxic Equivalency Factors 3 Table 3 to Subpart III of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Commercial...

  4. 40 CFR Table 4 to Subpart Llll of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Toxic Equivalency Factors 4 Table 4 to Subpart LLLL of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for New Sewage Sludge Incineration Units Pt. 60,...

  5. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State...

  6. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State...

  7. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State...

  8. 20 CFR 411.582 - Can a State VR agency receive payment under the cost reimbursement payment system if a continuous...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment...? Yes. If a State VR agency provides services to a beneficiary under 34 CFR part 361, and elects...

  9. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State...

  10. Assistance to Oil and Gas State Agencies and Industry through Continuation of Environmental and Production Data Management and a Water Regulatory Initiative

    SciTech Connect

    Grunewald, Ben; Arthur, Dan; Langhus, Bruce; Gillespie, Tom; Binder, Ben; Warner, Don; Roberts, Jim; Cox, D.O.

    2002-05-31

    This grant project was a major step toward completion of the Risk Based Data Management System (RBDMS) project. Additionally the project addresses the needs identified during the projects initial phases. By implementing this project, the following outcomes were sought: (1) State regulatory agencies implemented more formalized environmental risk management practices as they pertain to the production of oil and gas, and injection via Class II wells. (2) Enhancement of oil and gas production by implementing a management system supporting the saving of abandoned or idle wells located in areas with a relatively low environmental risk of endangering underground sources of drinking water (USDWs) in a particular state. (3) Verification that protection of USDWs is adequate and additional restrictions of requirements are not necessary in areas with a relatively low environmental risk. (4) Standardization of data and information maintained by state regulatory agencies and decrease the regulatory cost burden on producers operating in multiple states, and (5) Development of a system for electronic data transfer among operators and state regulatory agencies and reduction of overall operator reporting burdens.

  11. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly listed coke by-product and chlorotoluene production wastes. 268.38 Section 268.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND...

  12. ANALYSIS OF EPA (ENVIRONMENTAL PROTECTION AGENCY) PROTOCOL GASES USED FOR CALIBRATION AND AUDITS OF CONTINUOUS EMISSION MONITORING SYSTEMS AND AMBIENT AIR ANALYZERS - RESULTS OF AUDIT 6

    EPA Science Inventory

    A performance audit was conducted on EPA Protocol Gases used for calibration and audits of continuous emission monitoring systems and ambient air analyzers. Fifty gaseous pollutant calibraton standards were purchased from eleven specialty gas producers. These standards contained ...

  13. 10 CFR 607.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Federal agency or agency. 607.645 Section 607.645 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.645 Federal agency or agency. Department of Energy means the...

  14. Toxic Hazards Research Unit

    NASA Technical Reports Server (NTRS)

    Macewen, J. D.; Vernot, E. H.

    1971-01-01

    The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1970 through May 1971 reviewed. Modification of the animal exposure facilities primarily for improved human safety but also for experimental integrity and continuity are discussed. Acute toxicity experiments were conducted on hydrogen fluoride (HF), hydrogen chloride (HCl), nitrogen dioxide (NO2), and hydrogen cyanide (HCN) both singly and in combination with carbon dioxide (CO). Additional acute toxicity experiments were conducted on oxygen difluoride (OF2) and chlorine pentafluoride (ClF5). Subacute toxicity studies were conducted on methylisobutylketone and dichloromethane (methylene dichloride). The interim results of further chronic toxicity experiments on monomethylhydrazine (MMH) are also described.

  15. Solutions Network Formulation Report. Landsat Data Continuity Mission Simulated Data Products for Bureau of Land Management and Environmental Protection Agency Abandoned Mine Lands Decision Support

    NASA Technical Reports Server (NTRS)

    Estep, Leland

    2007-01-01

    Presently, the BLM (Bureau of Land Management) has identified a multitude of abandoned mine sites in primarily Western states for cleanup. These sites are prioritized and appropriate cleanup has been called in to reclaim the sites. The task is great in needing considerable amounts of agency resources. For instance, in Colorado alone there exists an estimated 23,000 abandoned mines. The problem is not limited to Colorado or to the United States. Cooperation for reclamation is sought at local, state, and federal agency level to aid in identification, inventory, and cleanup efforts. Dangers posed by abandoned mines are recognized widely and will tend to increase with time because some of these areas are increasingly used for recreation and, in some cases, have been or are in the process of development. In some cases, mines are often vandalized once they are closed. The perpetrators leave them open, so others can then access the mines without realizing the danger posed. Abandoned mine workings often fill with water or oxygen-deficient air and dangerous gases following mining. If the workings are accidentally entered into, water or bad air can prove fatal to those underground. Moreover, mine residue drainage negatively impacts the local watershed ecology. Some of the major hazards that might be monitored by higher-resolution satellites include acid mine drainage, clogged streams, impoundments, slides, piles, embankments, hazardous equipment or facilities, surface burning, smoke from underground fires, and mine openings.

  16. 77 FR 70780 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... HUMAN SERVICES Agency for Toxic Substances and Disease Registry Agency Forms Undergoing Paperwork... the Collection of Qualitative Feedback on Agency Service Delivery-NEW-Agency for Toxic Substances and... feedback from the public on service delivery, the ATSDR has submitted a Generic Information...

  17. 40 CFR Table 3 to Subpart X of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Subpart X of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Standards For Hazardous Air Pollutants From Secondary Lead Smelting Pt. 63, Subpt. X, Table 3 Table 3 to Subpart X of Part 63—Toxic Equivalency Factors Dioxin/furan congener Toxicequivalency factor...

  18. 40 CFR Table 4 to Subpart Dddd of... - Model Rule-Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Model Rule-Toxic Equivalency Factors 4 Table 4 to Subpart DDDD of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... or Before November 30, 1999 Pt. 60, Subpt. DDDD, Table 4 Table 4 to Subpart DDDD of Part...

  19. 78 FR 64210 - Extension of Review Periods Under the Toxic Substances Control Act; Certain Chemicals and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ...Due to the federal government shutdown related to the lack of authorized funding (i.e., a Fiscal Year 2014 Appropriations Bill or a Continuing Resolution), EPA is extending the review periods for all Premanufacture Notices (PMNs), Significant New Use Notices (SNUNs), Microbial Commercial Activity Notices (MCANs), and exemption notices submitted to the Agency under section 5 of the Toxic......

  20. 40 CFR Table 3 to Subpart Cccc of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Toxic Equivalency Factors 3 Table 3 to Subpart CCCC of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... factor 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1 1,2,3,7,8-pentachlorinated dibenzo-p-dioxin 0.5...

  1. 40 CFR Table 3 to Subpart Cccc of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Toxic Equivalency Factors 3 Table 3 to Subpart CCCC of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... factor 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1 1,2,3,7,8-pentachlorinated dibenzo-p-dioxin 0.5...

  2. 40 CFR Table 3 to Subpart III of... - Toxic Equivalency Factors

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Toxic Equivalency Factors 3 Table 3 to Subpart III of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Factors Dioxin/furan congener Toxicequivalency factor A. 2,3,7,8-tetrachlorinated dibenzo-p-dioxin 1 B....

  3. Toxic substances alert program

    NASA Technical Reports Server (NTRS)

    Junod, T. L.

    1978-01-01

    A toxicity profile is provided, of 187 toxic substances procured by NASA Lewis Research Center during a 3 1/2 year period, including 27 known or suspected carcinogens. The goal of the program is to assure that the center's health and safety personnel are aware of the procurement and use of toxic substances and to alert and inform the users of these materials as to the toxic characteristics and the control measures needed to ensure their safe use. The program also provides a continuing record of the toxic substances procured, who procured them, what other toxic substances the user has obtained in the past, and where similar materials have been used elsewhere at the center.

  4. 32 CFR 148.6 - Agency review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Agency review. 148.6 Section 148.6 National... Inspections of Facilities § 148.6 Agency review. Agencies will continue to review and assess the potential... government. As this review continues, agencies creating or modifying facilities databases will do so in...

  5. Development of inexpensive continuous emission monitors for feedback control of combustion devices that minimize greenhouse gases, toxic emissions, and ozone damaging products

    SciTech Connect

    Funk, D.J.; Moore, D.S.; Mongia, R.K.; Tomita, E.; Hsu, F.K.; Talbot, L.; Dibble, R.W.; Lovett, J.; Yamazaki, Akira

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development project at the Los Alamos National Laboratory. Combustion is the major cause of poor urban air quality, of depletion of the ozone layer, and a major source of the greenhouse gas, carbon dioxide. Careful control of combustor conditions is important for minimizing the effects of combustion on the environment. The authors have developed sensitive, inexpensive continuous emission monitors that will assist in direct feedback of turbine power systems and provide assurance to the public and the operators of the facilities that their facility emissions lie within the accepted bounds. These include a robust solid-state Fourier transform spectrometer for rapid gas analysis, based on the use of ferroelectric liquid crystal technology, and an infrared helium-neon probe for real time measurement of combustor air-to-fuel ratios.

  6. 40 CFR 131.38 - Establishment of Numeric Criteria for priority toxic pollutants for the State of California.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Establishment of Numeric Criteria for priority toxic pollutants for the State of California. 131.38 Section 131.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards §...

  7. 40 CFR 131.38 - Establishment of Numeric Criteria for priority toxic pollutants for the State of California.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Establishment of Numeric Criteria for priority toxic pollutants for the State of California. 131.38 Section 131.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards §...

  8. Mechanisms of phosphine toxicity.

    PubMed

    Nath, Nisa S; Bhattacharya, Ishita; Tuck, Andrew G; Schlipalius, David I; Ebert, Paul R

    2011-01-01

    Fumigation with phosphine gas is by far the most widely used treatment for the protection of stored grain against insect pests. The development of high-level resistance in insects now threatens its continued use. As there is no suitable chemical to replace phosphine, it is essential to understand the mechanisms of phosphine toxicity to increase the effectiveness of resistance management. Because phosphine is such a simple molecule (PH(3)), the chemistry of phosphorus is central to its toxicity. The elements above and below phosphorus in the periodic table are nitrogen (N) and arsenic (As), which also produce toxic hydrides, namely, NH(3) and AsH(3). The three hydrides cause related symptoms and similar changes to cellular and organismal physiology, including disruption of the sympathetic nervous system, suppressed energy metabolism and toxic changes to the redox state of the cell. We propose that these three effects are interdependent contributors to phosphine toxicity. PMID:21776261

  9. Management of digoxin toxicity

    PubMed Central

    Pincus, Matthew

    2016-01-01

    Summary Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms. It can also trigger fatal arrhythmias. There is a range of indications for using digoxin-specific antibody fragments. The amount ingested and serum digoxin concentration help to determine the dose required, but are not essential. Digoxin-specific antibody fragments are safe and effective in severe toxicity. Monitoring should continue after treatment because of the small risk of rebound toxicity. Restarting therapy should take into account the indication for digoxin and any reasons why the concentration became toxic. PMID:27041802

  10. Developmental Toxicity

    EPA Science Inventory

    This chapter provides an overview the developmental toxicity resulting from exposure to perfluorinated alkyl acids (PFAAs). The majority of studies of PFAA-induced developmental toxicity have examined effects of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA) a...

  11. Toxicity Studies.

    PubMed

    2016-01-01

    Toxicity studies in the animal models are done to determine the dose level recommended for the treatment of disease as drug. This guideline enables the characterization of adverse effects following repeated daily inhalation exposure to a test. This chapter includes oral and dermal toxicity studies which are discussed as per OECD guidelines. Both acute and subacute toxicity studies are given special emphasis. PMID:26939270

  12. Toxic action/toxicity.

    PubMed

    Hathway, D E

    2000-02-01

    Some six or so physiological systems, essential to normal mammalian life, are involved in poisoning; an intoxication that causes severe injury to any one of them could be life threatening. Reversible chemical reactions showing Scatchard-type binding are exemplified by CO, CN- and cyclodiene neurotoxin insecticide intoxications, and by antigen-antibody complex formation. Haemoglobin (Hb) molecular biology accounts for the allosteric co-operativity and other characteristics of CO poisoning, CN- acts as a powerful cytochrome oxidase inhibitor, and antigen binding in a deep antibody cleft between two domains equipped with epitopes for antigen-binding groups explains hapten-specific immune reactions. Covalent chemical reactions with second-order (SN2) kinetics characterize Hg and Cd poisonings, the reactions of organophosphates and phosphonates with acetylcholinesterase and neurotoxic esterase and the reaction sequence whereby Paraquat accepts electrons and generates superoxide under aerobic conditions. Indirect carcinogens require cytochrome P450 activation to form DNA adducts in target-organ DNA and cause cancer, but a battery of detoxifying enzymes clustered with the P450 system must be overcome. Thus, S-metabolism competes ineffectively with target DNA for reactive vinyl chloride (VC) metabolites, epoxide hydrolase is important to the metabolism and carcinogenicity of alfatoxins and polycyclic aromatic hydrocarbons (benzo[a]pyrene, etc.), and the non-toxic 2-naphthylhydroxylamine N-glucuronide acts as a transport form in 2-naphthylamine bladder cancer. VC liver-cancer pathogenesis is explicable in terms of the presence of the glutathione S-transferase detoxifying system in hepatocytes and its absence from the fibroblastic elements, and of the VC concentrations reaching the liver by different administrative routes. In VC carcinogenicity, chemical reactions give imidazo-cyclization products with nucleoside residues of target DNA, and in benzene leukaemia, Z

  13. 29 CFR 1614.102 - Agency program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Agency program. 1614.102 Section 1614.102 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Agency Program To Promote Equal Employment Opportunity § 1614.102 Agency program. (a) Each agency shall maintain a...

  14. Strengthening Career Human Agency

    ERIC Educational Resources Information Center

    Chen, Charles P.

    2006-01-01

    Rooted in A. Bandura's (1982, 2001b) social cognitive theory, the notion of human agency has received considerable attention in vocational and career psychology for the last 2 decades, especially with the recent emergence of social constructivist thinking in the field. This article continues in the same direction. In reviewing the notion of human…

  15. 5 CFR 720.204 - Agency programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Agency programs. 720.204 Section 720.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) AFFIRMATIVE EMPLOYMENT PROGRAMS Federal Equal Opportunity Recruitment Program § 720.204 Agency programs. (a) Each Executive agency...

  16. 5 CFR 831.1004 - Agency contributions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Agency contributions. 831.1004 Section 831.1004 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT CSRS Offset § 831.1004 Agency contributions. The employing agency, the Secretary...

  17. 5 CFR 831.1004 - Agency contributions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Agency contributions. 831.1004 Section 831.1004 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT CSRS Offset § 831.1004 Agency contributions. The employing agency, the Secretary of the Senate, and the Clerk of the House...

  18. 5 CFR 831.1004 - Agency contributions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Agency contributions. 831.1004 Section 831.1004 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT CSRS Offset § 831.1004 Agency contributions. The employing agency, the Secretary...

  19. 5 CFR 831.1004 - Agency contributions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Agency contributions. 831.1004 Section 831.1004 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT CSRS Offset § 831.1004 Agency contributions. The employing agency, the Secretary of the Senate, and the Clerk of the House...

  20. 5 CFR 919.910 - Agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Agency. 919.910 Section 919.910 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 919.910 Agency. Agency means any United States executive department,...

  1. TOXICITY OF SELECTED PRIORITY POLLUTANTS TO VARIOUS AQUATIC ORGANISMS

    EPA Science Inventory

    Toxicity tests were conducted with selected compounds listed by the United States Environmental Protection Agency (EPA) as priority pollutants. Acute toxicity information was determined for acenaphthene, arsenic trioxide, cadmium chloride, mercury(II) chloride, silver nitrate, ch...

  2. 78 FR 35296 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... SECURITY Federal Emergency Management Agency Agency Information Collection Activities; Proposed Collection; Comment Request AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency, as part of its continuing effort to reduce paperwork and respondent...

  3. 45 CFR 1173.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Federal agency or agency. 1173.645 Section 1173.645 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES GOVERNMENTWIDE REQUIREMENTS FOR...

  4. 45 CFR 1155.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Federal agency or agency. 1155.645 Section 1155.645 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE...

  5. Toxic Encephalopathy

    PubMed Central

    Kim, Jae Woo

    2012-01-01

    This article schematically reviews the clinical features, diagnostic approaches to, and toxicological implications of toxic encephalopathy. The review will focus on the most significant occupational causes of toxic encephalopathy. Chronic toxic encephalopathy, cerebellar syndrome, parkinsonism, and vascular encephalopathy are commonly encountered clinical syndromes of toxic encephalopathy. Few neurotoxins cause patients to present with pathognomonic neurological syndromes. The symptoms and signs of toxic encephalopathy may be mimicked by many psychiatric, metabolic, inflammatory, neoplastic, and degenerative diseases of the nervous system. Thus, the importance of good history-taking that considers exposure and a comprehensive neurological examination cannot be overemphasized in the diagnosis of toxic encephalopathy. Neuropsychological testing and neuroimaging typically play ancillary roles. The recognition of toxic encephalopathy is important because the correct diagnosis of occupational disease can prevent others (e.g., workers at the same worksite) from further harm by reducing their exposure to the toxin, and also often provides some indication of prognosis. Physicians must therefore be aware of the typical signs and symptoms of toxic encephalopathy, and close collaborations between neurologists and occupational physicians are needed to determine whether neurological disorders are related to occupational neurotoxin exposure. PMID:23251840

  6. How toxic is coal ash? A laboratory toxicity case study.

    PubMed

    Sherrard, Rick M; Carriker, Neil E; Greeley, Mark S

    2015-01-01

    Under a consent agreement among the Environmental Protection Agency (EPA) and proponents both for and against stricter regulation, EPA is to issue a new coal ash disposal rule by the end of 2014. Laboratory toxicity investigations often yield conservative estimates of toxicity because many standard test species are more sensitive than resident species, thus could provide information useful to the rule-making. However, few laboratory studies of coal ash toxicity are available; most studies reported in the literature are based solely on field investigations. This brief communication describes a broad range of toxicity studies conducted for the Tennessee Valley Authority (TVA) Kingston ash spill, results of which help provide additional perspective on the toxicity of coal ash. PMID:25348557

  7. How toxic is coal ash? A laboratory toxicity case study

    DOE PAGESBeta

    Sherrard, Rick M.; Carriker, Neil; Greeley, Jr., Mark Stephen

    2014-12-08

    Under a consent agreement among the Environmental Protection Agency (EPA) and proponents both for and against stricter regulation, EPA is to issue a new coal ash disposal rule by the end of 2014. Laboratory toxicity investigations often yield conservative estimates of toxicity because many standard test species are more sensitive than resident species, thus could provide information useful to the rule-making. However, few laboratory studies of coal ash toxicity are available; most studies reported in the literature are based solely on field investigations. In this paper, we describe a broad range of toxicity studies conducted for the Tennessee Valley Authoritymore » (TVA) Kingston ash spill, results of which help provide additional perspective on the toxicity of coal ash.« less

  8. How toxic is coal ash? A laboratory toxicity case study

    SciTech Connect

    Sherrard, Rick M.; Carriker, Neil; Greeley, Jr., Mark Stephen

    2014-12-08

    Under a consent agreement among the Environmental Protection Agency (EPA) and proponents both for and against stricter regulation, EPA is to issue a new coal ash disposal rule by the end of 2014. Laboratory toxicity investigations often yield conservative estimates of toxicity because many standard test species are more sensitive than resident species, thus could provide information useful to the rule-making. However, few laboratory studies of coal ash toxicity are available; most studies reported in the literature are based solely on field investigations. In this paper, we describe a broad range of toxicity studies conducted for the Tennessee Valley Authority (TVA) Kingston ash spill, results of which help provide additional perspective on the toxicity of coal ash.

  9. [Toxic polyneuropathies].

    PubMed

    Neundörfer, B

    1992-08-01

    Toxic factors may have damaging effects on the peripheral nerves at different sites: on the axon, on the myelin sheath, on the cell bodies and on the vasa nervorum. The toxic neuropathies can be divided up into polyneuropathies induced by drugs, by industrial, environmental and stimulant poisons. Mostly symmetrical sensory symptoms and signs are the first disturbances, often followed by symmetrical motor pareses. Some polyneuropathies induced by amiodarone, benzene, lead, cimetidine, chloroquine, dapsone, gentamycin, gold, imipramine, hexacarbons, nialamide, penicillin, triorthocresylphosphate and vincristine are primarily dominated by motory losses. Polyneuropathies induced by amitriptyline, ethylene, oxide, lead, chlorprothixene, heroin, hydralazine, methaqualone, nialamide and penicillin show an asymmetrical distribution pattern of the neural losses. In some types of toxic polyneuropathies the cranial nerves and the autonomic nerves are particularly involved. The clinical symptomatology of the most important types of toxic neuropathies are described shortly. The best therapy is, of course, termination of exposure to the toxic substance concerned. PMID:1509644

  10. 40 CFR 131.36 - Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B). 131.36 Section 131.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards § 131.36...

  11. 40 CFR 131.36 - Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B). 131.36 Section 131.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards § 131.36...

  12. 40 CFR 131.36 - Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B). 131.36 Section 131.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards § 131.36...

  13. 40 CFR 131.36 - Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Toxics criteria for those states not complying with Clean Water Act section 303(c)(2)(B). 131.36 Section 131.36 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally Promulgated Water Quality Standards § 131.36...

  14. Toxic releases from power plants

    SciTech Connect

    Rubin, E.S.

    1999-09-15

    Beginning in 1998, electric power plants burning coal or oil must estimate and report their annual releases of toxic chemicals listed in the Toxics Release Inventory (TRI) published by the US Environmental Protection Agency (EPA). This paper identifies the toxic chemicals of greatest significance for the electric utility sector and develops quantitative estimates of the toxic releases reportable to the TRI for a representative coal-fired power plant. Key factors affecting the magnitude and types of toxic releases for individual power plants also are discussed. A national projection suggests that the magnitude of electric utility industry releases will surpass those of the manufacturing industries which current report to the TRI. Risk communication activities at the community level will be essential to interpret and provide context for the new TRI results.

  15. CHATTANOOGA AIR TOXICS (CATS) MONITORING RISK ASSESSMENT

    EPA Science Inventory

    The Chattanooga-Hamilton County Air Pollution Control Bureau (CHCAPCB), the United States Environmental Protection Agency Region 4 (Region 4), and other stakeholders, in a cooperative effort, conducted an air toxics study in the Chattanooga area (city population approximately 285...

  16. Toxic trauma.

    PubMed

    Moles, T M; Baker, D J

    2001-01-01

    Hazardous materials (HAZMAT) carry many inherent dangers. Such materials are distributed widely in industrial and military sites. Toxic trauma (TT) denotes the complex of systemic and organ injury caused by toxic agents. Often, TT is associated with other injuries that also require the application of life-support techniques. Rapid onset of acute respiratory failure and consequent cardiovascular failure are of primary concern. Management of TT casualties is dependent upon the characteristics of the toxic agents involved and on the demographics surrounding the HAZMAT incident. Agents that can produce TT possess two pairs of salient characteristics: (1) causality (toxicity and latency), and (2) EMS system (persistency and transmissibility). Two characteristics of presentations are important: (1) incident presentation, and (2) casualty presentation. In addition, many of these agents complicate the processes associated with anaesthesia and must be dealt with. Failure of recognition of these factors may result in the development of respiratory distress syndromes and multiorgan system failure, or even death. PMID:11513285

  17. Digitalis toxicity

    MedlinePlus

    These are symptoms of digitalis toxicity: Confusion Irregular pulse Loss of appetite Nausea , vomiting , diarrhea Fast heartbeat Vision changes (unusual), including blind spots, blurred vision, changes in how colors look, or ...

  18. Antimony Toxicity

    PubMed Central

    Sundar, Shyam; Chakravarty, Jaya

    2010-01-01

    Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. In addition antimony trioxide is possibly carcinogenic to humans. Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. Quality control of each batch of drugs produced and regular monitoring for toxicity is required when antimonials are used therapeutically. PMID:21318007

  19. AIR TOXICS HUMAN EXPOSURE MODELING

    EPA Science Inventory

    This project aims to improve the scientific basis for the Environmental Protection Agency's (EPA's) assessments of human exposures to air toxics by developing improved human exposure models. The research integrates the major components of the exposure paradigm, i.e., sources, tr...

  20. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  1. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  2. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  3. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  4. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  5. 5 CFR 841.504 - Agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certification in an internal automated system of records. (e) An agency must maintain payroll systems and... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Employee Deductions and...

  6. 5 CFR 841.504 - Agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certification in an internal automated system of records. (e) An agency must maintain payroll systems and... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Employee Deductions and...

  7. 5 CFR 841.504 - Agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certification in an internal automated system of records. (e) An agency must maintain payroll systems and... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Employee Deductions and...

  8. 5 CFR 841.504 - Agency responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certification in an internal automated system of records. (e) An agency must maintain payroll systems and... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Employee Deductions and...

  9. 5 CFR 841.504 - Agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... certification in an internal automated system of records. (e) An agency must maintain payroll systems and... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Employee Deductions and...

  10. Evaluations in support of regulatory and research decisions by the U. S. Environmental Protection Agency for the control of toxic hazards from hazardous wastes, glyphosate, dalapon, and synthetic fuels

    SciTech Connect

    Scofield, R.

    1984-01-01

    This report includes toxicological and regulatory evaluations performed in support of U.S. EPA regulation of toxic materials and hazardous wastes. The first section of the report describes evaluations which support: (a) the regulation of small-volume generators of hazardous wastes, (b) the regulation of hazardous wastes from pesticide manufacturing, and (c) the disposal of the herbicide, silvex. The second section describes the environmental fate, transport, and effect of glyphosate and dalapon. The third section deals with synthetic fuels, including evaluations of synfuel-product toxicity, uncontrolled air emissions, and particular focus on the toxicity of products from several indirect coal liquefaction processes including methanol synthesis, Fischer-Tropsch, Mobil M-Gasoline, and Lurgi gasification technologies. Three direct coal liquefaction processes were examined for product toxicity and air emissions: Solvent Refined Coal (I and II) and the Exxon Donor Solvent Process. Also described in the third section is an evaluation of environmental and health hazards associated with the use of synthetic fuels from indirect coal liquefaction, direct coal liquefaction, and shale oil. Finally, the fourth section discusses some problems associated with performing, on a contractual basis, scientific and technical evaluations in support of U.S. EPA regulatory and research decisions.

  11. PRINCIPLES OF DEVELOPMENTAL TOXICITY RISK ASSESSMENT

    EPA Science Inventory

    Developmental toxicity testing over the last three decades has provided considerable data that have been used by regulatory agencies to set standards and to regulate exposures. s part of a larger guidelines effort, the Environmental Protection Agency (EPA) published guidelines fo...

  12. Federal Agencies

    ERIC Educational Resources Information Center

    Kyle, George M.

    1976-01-01

    The status of two of life's necessities, air and water, is of crucial importance to the future of American parks and recreation programs, and continued cooperation among federal, state, local and private sectors is necessary to preserve them. (JD)

  13. Lead toxicity: a review

    PubMed Central

    Ara, Anjum; Usmani, Jawed Ahmad

    2015-01-01

    Lead toxicity is an important environmental disease and its effects on the human body are devastating. There is almost no function in the human body which is not affected by lead toxicity. Though in countries like US and Canada the use of lead has been controlled up to a certain extent, it is still used vehemently in the developing countries. This is primarily because lead bears unique physical and chemical properties that make it suitable for a large number of applications for which humans have exploited its benefits from historical times and thus it has become a common environmental pollutant. Lead is highly persistent in the environment and because of its continuous use its levels rise in almost every country, posing serious threats. This article reviews the works listed in the literature with recent updates regarding the toxicity of lead. Focus is also on toxic effects of lead on the renal, reproductive and nervous system. Finally the techniques available for treating lead toxicity are presented with some recent updates. PMID:27486361

  14. Continual improvement plan

    NASA Technical Reports Server (NTRS)

    1994-01-01

    NASA's approach to continual improvement (CI) is a systems-oriented, agency-wide approach that builds on the past accomplishments of NASA Headquarters and its field installations and helps achieve NASA's vision, mission, and values. The NASA of the future will fully use the principles of continual improvement in every aspect of its operations. This NASA CI plan defines a systematic approach and a model for continual improvement throughout NASA, stressing systems integration and optimization. It demonstrates NASA's constancy of purpose for improvement - a consistent vision of NASA as a worldwide leader in top-quality science, technology, and management practices. The CI plan provides the rationale, structures, methods, and steps, and it defines NASA's short term (1-year) objectives for improvement. The CI plan presents the deployment strategies necessary for cascading the goals and objectives throughout the agency. It also provides guidance on implementing continual improvement with participation from top leadership and all levels of employees.

  15. Toxic Myopathies

    PubMed Central

    Pasnoor, Mamatha; Barohn, Richard J.; Dimachkie, Mazen M.

    2014-01-01

    Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, as they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features and possible underlying cellular mechanisms. PMID:25037083

  16. 29 CFR 1614.104 - Agency processing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Agency processing. 1614.104 Section 1614.104 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Agency Program To Promote Equal Employment Opportunity § 1614.104 Agency...

  17. 34 CFR 303.22 - Lead agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Lead agency. 303.22 Section 303.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 303.22 Lead agency. Lead agency means the...

  18. 34 CFR 303.22 - Lead agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Lead agency. 303.22 Section 303.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 303.22 Lead agency. Lead agency means the...

  19. 34 CFR 303.22 - Lead agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Lead agency. 303.22 Section 303.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 303.22 Lead agency. Lead agency means the...

  20. 40 CFR 166.25 - Agency review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Agency review. 166.25 Section 166.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and...

  1. 40 CFR 166.25 - Agency review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Agency review. 166.25 Section 166.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and...

  2. 40 CFR 166.25 - Agency review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Agency review. 166.25 Section 166.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and...

  3. Toxic remediation

    DOEpatents

    Matthews, Stephen M.; Schonberg, Russell G.; Fadness, David R.

    1994-01-01

    What is disclosed is a novel toxic waste remediation system designed to provide on-site destruction of a wide variety of hazardous organic volatile hydrocarbons, including but not limited to halogenated and aromatic hydrocarbons in the vapor phase. This invention utilizes a detoxification plenum and radiation treatment which transforms hazardous organic compounds into non-hazardous substances.

  4. Continuing Education Survey.

    ERIC Educational Resources Information Center

    Bird, K. A.; Fenwick, P. R.

    In 1978, a national survey was conducted in New Zealand to determine the extent of participation in continuing education and the level of unmet need for these activities. A questionnaire was developed dealing with respondent characteristics, spare time and interests, agency-directed learning activities (ADLAS), and unmet needs, and administered to…

  5. GENE INDUCTION STUDIES AND TOXICITY OF CHEMICAL MIXTURES

    EPA Science Inventory

    As part of its mixtures program the Agency for Toxic Substances and Disease Registry (ATSDR) supports in vitro and limited in vivo toxicity testing to further our understanding of the toxicity and health effects of chemical mixtures. There are increasing concerns that environment...

  6. 5 CFR 720.204 - Agency programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Agency programs. 720.204 Section 720.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) AFFIRMATIVE EMPLOYMENT PROGRAMS Federal Equal Opportunity Recruitment Program § 720.204 Agency programs....

  7. 5 CFR 720.303 - Agency programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Agency programs. 720.303 Section 720.303 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) AFFIRMATIVE EMPLOYMENT PROGRAMS Disabled Veterans Affirmative Action Program § 720.303 Agency programs....

  8. 5 CFR 720.204 - Agency programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Agency programs. 720.204 Section 720.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) AFFIRMATIVE EMPLOYMENT PROGRAMS Federal Equal Opportunity Recruitment Program § 720.204 Agency programs....

  9. Keeping tabs on toxics.

    PubMed

    Young, J E

    1992-01-01

    The Toxic Release Inventory (TRI) is a list of all chemicals released by over 22,000 manufacturing sites across the US. The TRI was established by the Emergency Planning and Community Right to Know Act of 1986. The TRI is managed by the Environmental Protection Agency. It was opposed by the Reagan administration and many industry groups because it was seen as an increase in government paper work and regulation. It has turned out to be an easy-to-manage stimulate to change. Industry leaders have even proclaimed its ability to help raise awareness of pollution in the industry. The TRI is accessible through computers with modems on the TOXNET system at the National Library of Medicine in Bethesda for about 25$-35$/hour. It is also available through RTK NET which is operated jointly by OMB Watch and the Unison Institute. TRI is by no means complete. It covers an estimated 5% of the total toxic release in the US. It monitors the release of only 330 toxic chemicals leaving about 500 more out. It does not count releases from sites that process less then 25,000 pounds or that use less than 10,000 pounds of a listed chemical. It also only monitors steel, paper, chemical, petroleum refining activities. It does not monitor the releases from other manufacturing like oil and gas extraction, warehousing, transportation, hazardous waste disposal, incineration, and mining. PMID:12317431

  10. Toxicity of nanomaterials

    PubMed Central

    Sharifi, Shahriar; Behzadi, Shahed; Laurent, Sophie; Forrest, M. Laird; Stroeve, Pieter

    2015-01-01

    Nanoscience has matured significantly during the last decade as it has transitioned from bench top science to applied technology. Presently, nanomaterials are used in a wide variety of commercial products such as electronic components, sports equipment, sun creams and biomedical applications. There are few studies of the long-term consequences of nanoparticles on human health, but governmental agencies, including the United States National Institute for Occupational Safety and Health and Japan’s Ministry of Health, have recently raised the question of whether seemingly innocuous materials such as carbon-based nanotubes should be treated with the same caution afforded known carcinogens such as asbestos. Since nanomaterials are increasing a part of everyday consumer products, manufacturing processes, and medical products, it is imperative that both workers and end-users be protected from inhalation of potentially toxic NPs. It also suggests that NPs may need to be sequestered into products so that the NPs are not released into the atmosphere during the product’s life or during recycling. Further, non-inhalation routes of NP absorption, including dermal and medical injectables, must be studied in order to understand possible toxic effects. Fewer studies to date have addressed whether the body can eventually eliminate nanomaterials to prevent particle build-up in tissues or organs. This critical review discusses the biophysicochemical properties of various nanomaterials with emphasis on currently available toxicology data and methodologies for evaluating nanoparticle toxicity. PMID:22170510

  11. Toxic chemical release inventory information.

    PubMed

    Bronson, R J

    1991-01-01

    As part of a U.S. government effort to inform the public about toxic or hazardous chemicals released into the environment, the National Library of Medicine (NLM) and the Environmental Protection Agency (EPA) are jointly producing the TRI (Toxic Chemical Release Inventory) databanks which consist of two separate files, TRI87 and TRI88. Both files reside on NLM's TOX-NET system. The files contain geographic information about reporting facilities and land, air, and water release data for approximately 300 listed chemicals. PMID:10111718

  12. Beyond toxicity

    PubMed Central

    García, Irene; Gotor, Cecilia; Romero, Luis C

    2014-01-01

    In non-cyanogenic plants, cyanide is a co-product of ethylene and camalexin biosynthesis. To maintain cyanide at non-toxic levels, Arabidopsis plants express the mitochondrial β-cyanoalanine synthase CYS-C1. CYS-C1 knockout leads to an increased level of cyanide in the roots and leaves and a severe defect in root hair morphogenesis, suggesting that cyanide acts as a signaling factor in root development. During compatible and incompatible plant-bacteria interactions, cyanide accumulation and CYS-C1 gene expression are negatively correlated. Moreover, CYS-C1 mutation increases both plant tolerance to biotrophic pathogens and their susceptibility to necrotrophic fungi, indicating that cyanide could stimulate the salicylic acid-dependent signaling pathway of the plant immune system. We hypothesize that CYS-C1 is essential for maintaining non-toxic concentrations of cyanide in the mitochondria to facilitate cyanide’s role in signaling. PMID:24398435

  13. Toxic gases.

    PubMed Central

    Matthews, G.

    1989-01-01

    An overview of the widespread use of gases and some volatile solvents in modern society is given. The usual circumstances in which undue exposure may occur are described. The most prominent symptoms and general principles of diagnosis and treatment are given and are followed by more specific information on the commoner, more toxic materials. While acute poisonings constitute the greater part of the paper, some indication of chronic disorders arising from repeated or prolonged exposure is also given. PMID:2687827

  14. Thallium toxicity.

    PubMed

    Galván-Arzate, S; Santamaría, A

    1998-09-30

    Thallium (T1+) is a toxic heavy metal which was accidentally discovered by Sir William Crookes in 1861 by burning the dust from a sulfuric acid industrial plant. He observed a bright green spectral band that quickly disappeared. Crookes named the new element 'Thallium' (after thallos meaning young shoot). In 1862, Lamy described the same spectral line and studied both the physical and chemical properties of this new element (Prick, J.J.G., 1979. Thallium poisoning. In: Vinkrn, P.J., Bruyn, G.W. (Eds.), Intoxication of the Nervous System, Handbook of Clinical Neurology, vol. 36. North-Holland, New York. pp. 239-278). PMID:9801025

  15. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Local agency appeals of State agency actions. 247.35 Section 247.35 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35 Local agency appeals of State...

  16. Cadmium as a respiratory toxicant

    SciTech Connect

    Grose, E.C.; Graham, J.A.

    1987-01-01

    Cadmium is a major respiratory toxicant as evidenced by numerous human and animal studies. Controlled animal inhalation studies provide supporting evidence to the associations observed in epidemiological studies that Cd has the potential to cause lung fibrosis, emphysema, cancer, and kidney disease after prolonged exposure. Shorter-term exposure studies indicate that mechanisms thought to be involved in several of these chronic disease states (especially fibrosis and emphysema) are acutely activated. The evidence of toxicity is sufficiently clear that a TLV has been set and the International Agency for Research on Cancer has named Cd as a Group B1 substance (probable human carcinogen). The risk to Cd exposure is enhanced by its chemical and physical properties that result in bioaccumulation. Thus, even a low-level exposure over long periods of time would be expected to reach doses that could be toxic.

  17. Toxic chemicals and toxic laws

    SciTech Connect

    Koshland, D.E. Jr.

    1991-08-30

    Recently there was consternation when it was discovered that a program intended to help minorities and the underprivileged in Detroit might have to be canceled. The reason was that some of the land on which new buildings were built was thought to contain toxic chemicals and therefore fell under the provisions of the Comprehensive Environmental Response, Compensation, and Liability Act (or Superfund). This collision of two valuable programs illustrates how a program originally heralded to carry out a worthwhile goal can become flawed. Since 1980, when the Superfund Act was passed by an overwhelming majority in Congress, only 34 of 1,245 identified priority sites have been cleaned up while approximately 40% of the money has been spent in trial litigation and administrative oversight. Critics, many of them within the EPA, point out that if the chemical danger level had been scientifically determined, approximately 90% of the truly important sites could have been cleaned up by now and the money wisely spent. However, the program was designed so that Congress initially did not have to raise much money or raise taxes and instead could argue that the program would not cost the taxpayer anything because it soaked the corporations. What needs to be done First, priority decisions should be taken out of the hands of nonscientists and lawyers and placed in those of scientists who are knowledgeable about toxic agents, who can identify effective targets objectively and who can establish workable priorities for removal of toxic waste. Second, a significant fraction of the money should be dedicated to research and to new programs that are more cost-effective. The purpose is to get chemical manufacturers thinking about reducing pollutants and the cost of cleanup when they plan to manufacture a chemical.

  18. TOXICITY OF RESIDUAL CHLORINE COMPOUNDS TO AQUATIC ORGANISMS

    EPA Science Inventory

    Laboratory studies on the acute and chronic toxicity of chlorine and inorganic chloramines to trout, salmon, minnows, bullhead, largemouth bass, and bluegill were conducted. Acute toxicity under continuous and intermittent patterns of exposure as well as behavioral, reproduction,...

  19. 75 FR 69086 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Amyotrophic Lateral Sclerosis (ALS)--New--Agency for Toxic Substances and Disease Registry (ATSDR). Background... amended the Public Health Service Act to provide for the establishment of an Amyotrophic Lateral...

  20. 76 FR 55393 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Storms (CHATS)--New--National Center for Environmental Health (NCEH) and Agency for Toxic Substances and... Health Study''); however, the goals remain the same. The Children's Health Study After the Storms...

  1. Perspectives: The Continuous Improvement Trap

    ERIC Educational Resources Information Center

    Arnold, David L.

    2011-01-01

    Accrediting agencies, legislators, pundits, and even higher educational professionals have become enamored with applying the language of continuous improvement to learning outcomes. The Southern Association of Colleges and Schools Commission on Colleges specifically uses the term "continuing improvement" in Core Standard 2.5, one of its…

  2. 29 CFR 1601.74 - Designated and notice agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Designated and notice agencies. 1601.74 Section 1601.74 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS FEP Agency Designation Procedures § 1601.74 Designated and notice agencies. (a) The designated FEP agencies are: Alaska Commission for...

  3. 29 CFR 1601.74 - Designated and notice agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Designated and notice agencies. 1601.74 Section 1601.74 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS FEP Agency Designation Procedures § 1601.74 Designated and notice agencies. (a) The designated FEP agencies are: Alaska Commission for...

  4. 29 CFR 1601.80 - Certified designated FEP agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Certified designated FEP agencies. 1601.80 Section 1601.80 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS FEP Agency Designation Procedures § 1601.80 Certified designated FEP agencies. The designated FEP agencies receiving certification by...

  5. 29 CFR 1601.80 - Certified designated FEP agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Certified designated FEP agencies. 1601.80 Section 1601.80 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS FEP Agency Designation Procedures § 1601.80 Certified designated FEP agencies. The designated FEP agencies receiving certification by...

  6. 5 CFR 731.205 - Debarment by agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Debarment by agencies. 731.205 Section... (CONTINUED) SUITABILITY Suitability Determinations and Actions § 731.205 Debarment by agencies. (a) Subject... specific covered, positions within that agency. (b) The agency may impose an additional period of...

  7. 5 CFR 731.205 - Debarment by agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Debarment by agencies. 731.205 Section... (CONTINUED) SUITABILITY Suitability Determinations and Actions § 731.205 Debarment by agencies. (a) Subject... specific covered, positions within that agency. (b) The agency may impose an additional period of...

  8. 40 CFR 93.154 - Federal agency conformity responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Federal agency conformity responsibility. 93.154 Section 93.154 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency conformity responsibility. Any department, agency, or instrumentality of the Federal...

  9. 40 CFR 93.154 - Federal agency conformity responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Federal agency conformity responsibility. 93.154 Section 93.154 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency conformity responsibility. Any department, agency, or instrumentality of the Federal...

  10. 40 CFR 93.154 - Federal agency conformity responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Federal agency conformity responsibility. 93.154 Section 93.154 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency conformity responsibility. Any department, agency, or instrumentality of the Federal...

  11. 40 CFR 93.154 - Federal agency conformity responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Federal agency conformity responsibility. 93.154 Section 93.154 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency conformity responsibility. Any department, agency, or instrumentality of the Federal...

  12. Toxic terror

    SciTech Connect

    Whelan, E.M.

    1985-01-01

    A review of toxic materials in the environment explores the evolution of public awareness of the problem, public and governmental reaction, the effort to establish standards of safe levels and danger thresholds, and the struggle to implement and enforce environmental policy. Separate chapters deal with environmental premises and scientific realities, the DDT debate and birth of environmentalism, the disaster of Love Canal, pesticides, PCBs, PBBs, formaldehyde, dioxin, air pollution, water pollution, nuclear energy and radioactive materials, acid rain, and the status of American health. The book concludes with a chapter on the need for scientific research and hard evidence to either prove or disprove the pessimism of those who warn of a threat to human health and survival.

  13. 40 CFR 56.7 - State agency performance audits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 6 2012-07-01 2012-07-01 false State agency performance audits. 56.7 Section 56.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.7 State agency performance audits. (a) EPA will utilize the provisions of...

  14. 40 CFR 56.7 - State agency performance audits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false State agency performance audits. 56.7 Section 56.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.7 State agency performance audits. (a) EPA will utilize the provisions of...

  15. 40 CFR 56.7 - State agency performance audits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false State agency performance audits. 56.7 Section 56.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.7 State agency performance audits. (a) EPA will utilize the provisions of...

  16. 40 CFR 56.7 - State agency performance audits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false State agency performance audits. 56.7 Section 56.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.7 State agency performance audits. (a) EPA will utilize the provisions of...

  17. 40 CFR 56.7 - State agency performance audits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 6 2014-07-01 2014-07-01 false State agency performance audits. 56.7 Section 56.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.7 State agency performance audits. (a) EPA will utilize the provisions of...

  18. Continuous Problem of Function Continuity

    ERIC Educational Resources Information Center

    Jayakody, Gaya; Zazkis, Rina

    2015-01-01

    We examine different definitions presented in textbooks and other mathematical sources for "continuity of a function at a point" and "continuous function" in the context of introductory level Calculus. We then identify problematic issues related to definitions of continuity and discontinuity: inconsistency and absence of…

  19. 28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual...

  20. 28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual...

  1. 28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual...

  2. Ranking chemicals based on chronic toxicity data.

    PubMed

    De Rosa, C T; Stara, J F; Durkin, P R

    1985-12-01

    During the past 3 years, EPA's ECAO/Cincinnati has developed a method to rank chemicals based on chronic toxicity data. This ranking system reflects two primary attributes of every chemical: the minimum effective dose and the type of effect elicited at that dose. The purpose for developing this chronic toxicity ranking system was to provide the EPA with the technical background required to adjust the RQs of hazardous substances designated in Section 101(14) of CERCLA or "Superfund." This approach may have applications to other areas of interest to the EPA and other regulatory agencies where ranking of chemicals based on chronic toxicity is desired. PMID:3843499

  3. 77 FR 76077 - Agency Information Collection Activities: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION...)), and as part of its continuing effort to reduce paperwork and respondent burden, the National...

  4. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Agency finding. 1794.43 Section 1794.43 Agriculture... (CONTINUED) ENVIRONMENTAL POLICIES AND PROCEDURES Procedure for Environmental Assessments § 1794.43 Agency... quality of the human environment, RUS will prepare a FONSI. Upon authorization of RUS, the applicant...

  5. 34 CFR 303.30 - Public agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Public agency. 303.30 Section 303.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 303.30 Public agency. As used in this part, public...

  6. 7 CFR 247.3 - Administering agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administering agencies. 247.3 Section 247.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.3 Administering agencies....

  7. 5 CFR 720.303 - Agency programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) AFFIRMATIVE EMPLOYMENT PROGRAMS Disabled Veterans Affirmative Action Program § 720.303 Agency programs. (a.... Postal Service and the Postal Rate Commission, shall conduct a continuing affirmative program for the... then be translated into action items....

  8. GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY

    EPA Science Inventory

    SOT 2005 SESSION ABSTRACT

    GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY

    David J. Dix. National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle...

  9. Investigating the Toxicity and Environmental Fate of Graphene Nanomaterials

    EPA Science Inventory

    The Hersam Laboratory at Northwestern University works with the Center for Environmental Implications of Nanotechnology and the United States Environmental Protection Agency to study the toxicity and environmental fate of emergent nanomaterials, specifically carbon-based nanomate...

  10. THE TOXCAST PROGRAM FOR PRIORITIZING TOXICITY TESTING OF ENVIRONMENTAL CHEMICALS

    EPA Science Inventory

    The United States Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources towards chemicals...

  11. Sediment Toxicity Identification Evaluation

    EPA Science Inventory

    Approach combining chemical manipulations and aquatic toxicity testing, generally with whole organisms, to systematically characterize, identify and confirm toxic substances causing toxicity in whole sediments and sediment interstitial waters. The approach is divided into thre...

  12. Multiple Air-Toxics Exposure Study Working Paper Number 3. Urban air-toxics exposure model: development and application

    SciTech Connect

    Not Available

    1988-11-01

    The South Coast Air Quality Management District of California completed a Multiple Air Toxics Exposure Study (MATES) that examines the additive risk from a number of air toxics on an urban area. The project, though partially funded by EPA, is an example of how a State or local agency may approach assessing their local air-toxics risks as is encouraged by EPA's Urban Air Toxics Program which results from EPA's Air Toxic Strategy. The report is a summary of the methods used by the California agency. Though not intended as an endorsement of the entire contents of the report, EPA is reproducing their report (Working Paper Number 3) to benefit and encourage other agencies that may be contemplating such an assessment.

  13. 40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous...

  14. 40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous...

  15. 40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous...

  16. 40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous...

  17. 40 CFR 63.7121 - How do I demonstrate continuous compliance with the emission limitations standard?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous...

  18. 40 CFR 63.6635 - How do I monitor and collect data to demonstrate continuous compliance?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emissions Standards for Hazardous Air Pollutants for...

  19. 40 CFR 63.7120 - How do I monitor and collect data to demonstrate continuous compliance?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for...

  20. BIOMONITORING TO ACHIEVE CONTROL OF TOXIC EFFLUENTS

    EPA Science Inventory

    This 48 - page Technology Transfer Report provides a case study of how water quality-based toxicity control procedures can be combined with chemical analyses and biological stream surveys to achieve more effective water pollution control. t describes how regulatory agencies used ...

  1. THE METABOLIC BASIS OF ARSENIC TOXICITY

    EPA Science Inventory

    The Metabolic Basis of Arsenic Toxicity

    David J. Thomas, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC

    Methylati...

  2. Chronic toxicity of biphenyl to Daphnia magna Straus

    SciTech Connect

    Gersich, F.M.; Bartlett, E.A.; Murphy, P.G.; Milazzo, D.P. )

    1989-09-01

    The US Environmental Protection Agency (EPA) issued a final test rule (1985) for biphenyl on the authority of Section 4(a) of the Toxic Substances Control Act (TSCA). Contained within this rule was the requirement for generating chronic daphnid toxicity data for biphenyl. Biphenyl is used primarily to produce dye carriers, heat-transfer fluids and alkylated biphenyls. The acute toxicity of biphenyl to Daphnia magna has been reported. The 48-hr LC50 values were 4.7 and 2.1 mg/L, respectively. To date, the chronic toxicity of biphenyl to fish and aquatic invertebrates has not been investigated. The objective of this study was to determine the chronic toxicity of biphenyl to D. magna. The daphnid chronic toxicity test is designed to estimate the maximum acceptable toxicant concentration (MATC). The MATC is defined as the concentration falling between the highest concentration showing no effect and the next higher concentration showing a toxic effect when compared to the controls.

  3. [Toxic cirrhosis].

    PubMed

    Kawasaki, H; Murawaki, Y; Yamada, S; Yamamoto, T

    1994-01-01

    Carbon tetrachloride induces diffuse fatty degeneration and centrilobular necrosis in the liver and the severity of liver injury is roughly proportional to the dosage administered. Nonetheless, the incidence of cirrhosis by this agent is rare. Several drugs, including methyldopa, methotrexate, isoniazid and vitamin A, have occasionally been reported to cause chronic active hepatitis, fibrosis and cirrhosis. There is no question that continued administration of the drug in the presence of clinically apparent hepatitis can lead to chronic active hepatitis, fibrosis and cirrhosis. Early recognition that a therapeutic drug is the probable cause of liver injury, followed by prompt withdrawal of such a drug, generally suffices in the management of drug-induced chronic liver disease. PMID:8114307

  4. Environmental Protection Agency

    MedlinePlus

    ... Menu Learn the Issues Air Chemicals and Toxics Climate Change Emergencies Greener Living Health & Safety Land & Cleanup Pesticides Waste Water Science & Technology Air Climate Change Ecosystems Health Land, Waste & Cleanup Pesticides Substances & Toxics ...

  5. 77 FR 13061 - Electronic Reporting of Toxics Release Inventory Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ...Facilities that currently report Toxics Release Inventory (TRI) data to the U.S. Environmental Protection Agency (EPA) use either paper reporting forms or the online reporting software application known as the Toxics Release Inventory-Made Easy Web or simply TRI- MEweb. Effective January 1, 2013, EPA proposes to require facilities to report non-confidential TRI data to EPA using electronic......

  6. Toxicity Relationship Analysis Program (TRAP) Version 1.21

    EPA Science Inventory

    The Toxicity Relationship Analysis Program (TRAP) fits a sigmoidal toxic response versus exposure variable relationship to standard toxicity test data. It will analyze binary (e.g., survival) or continuous (e.g., growth, reproduction) biological effect variables as a function o...

  7. 15 CFR 1180.8 - Appointment of Agency Liaison Officers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE TRANSFER BY FEDERAL AGENCIES OF SCIENTIFIC, TECHNICAL AND ENGINEERING INFORMATION TO THE NATIONAL TECHNICAL INFORMATION SERVICE § 1180.8 Appointment...

  8. 15 CFR 1180.8 - Appointment of Agency Liaison Officers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE TRANSFER BY FEDERAL AGENCIES OF SCIENTIFIC, TECHNICAL AND ENGINEERING INFORMATION TO THE NATIONAL TECHNICAL INFORMATION SERVICE § 1180.8 Appointment...

  9. 15 CFR 1180.8 - Appointment of Agency Liaison Officers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE TRANSFER BY FEDERAL AGENCIES OF SCIENTIFIC, TECHNICAL AND ENGINEERING INFORMATION TO THE NATIONAL TECHNICAL INFORMATION SERVICE § 1180.8 Appointment...

  10. 15 CFR 1180.8 - Appointment of Agency Liaison Officers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE TRANSFER BY FEDERAL AGENCIES OF SCIENTIFIC, TECHNICAL AND ENGINEERING INFORMATION TO THE NATIONAL TECHNICAL INFORMATION SERVICE § 1180.8 Appointment...

  11. 38 CFR 21.7200 - State approving agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION All Volunteer Force Educational Assistance Program... activities; and (f) Section 21.4155—Evaluation of State approving agency performance. (Authority: 38...

  12. 38 CFR 21.7200 - State approving agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION All Volunteer Force Educational Assistance Program... activities; and (f) Section 21.4155—Evaluation of State approving agency performance. (Authority: 38...

  13. 78 FR 52860 - Electronic Reporting of Toxics Release Inventory Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... ``Electronic Reporting of Toxics Release Inventory Data'' (March 5, 2012; 77 FR 13061). These comments are... EPA--U.S. Environmental Protection Agency EPCRA--Emergency Planning and Community Right-to-Know Act FR... notice in the Federal Register (76 FR 2677) that the Agency was considering requiring TRI facilities...

  14. EVALUATION OF ALTERNATIVE REFERENCE TOXICANTS FOR USE IN THE EARTHWORM TOXICITY TEST

    EPA Science Inventory

    The use of the 14-d earthworm toxicity test to aid in the evaluation of the ecological impact of contaminated soils is becoming increasingly widespread. However,the method is in need of further standardization. As part of this continuing process, the choice of reference toxicants...

  15. 5 CFR 792.105 - Agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Agency responsibilities. 792.105 Section 792.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' HEALTH, COUNSELING, AND WORK/LIFE PROGRAMS Alcoholism and Drug Abuse...

  16. 5 CFR 792.105 - Agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Agency responsibilities. 792.105 Section 792.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' HEALTH, COUNSELING, AND WORK/LIFE PROGRAMS Alcoholism and Drug Abuse...

  17. 5 CFR 792.105 - Agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Agency responsibilities. 792.105 Section 792.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and...

  18. 5 CFR 792.105 - Agency responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Agency responsibilities. 792.105 Section 792.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and...

  19. 5 CFR 724.103 - Agency obligations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Agency obligations. 724.103 Section 724.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION...

  20. 5 CFR 724.103 - Agency obligations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Agency obligations. 724.103 Section 724.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION...

  1. 5 CFR 720.304 - Agency plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED... upon request. The Office of Personnel Management will review a selection of agency plans each fiscal... of the action plan. (3) An assessment of the current status of disabled veteran employment within...

  2. 32 CFR 318.10 - Appeal of initial adverse Agency determination for access, correction or amendment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE THREAT REDUCTION AGENCY... Threat Reduction Agency, 45045 Aviation Drive, Dulles, VA 20166-7517. (c) The requester shall provide...

  3. Corrosion-induced Whole Effluent Toxicity from a cooling tower: A toxicity reduction evaluation case study

    SciTech Connect

    Fort, D.J.; Stover, E.L.; Talley, J.M.; Copenhaver, M.B.

    1996-11-01

    As the result of Whole Effluent Toxicity (WET) test failures with Daphnia pulex, the US Environmental Protection Agency (EPA) required an industrial facility discharging approximately 5 million gallons per day (MGD) of recirculating cooling water obtained from a large freshwater river to conduct a Toxicity Reduction Evaluation (TRE) program. Under the terms of the National Pollutant Discharge Elimination System (NPDES) permit, the facility was required to conduct 48-hour acute toxicity tests with D. pulex and Pimephales promelas (fathead minnow). Although effluent toxicity to D. pulex was consistently observed, no toxicity was induced to the fathead minnow during the TRE program. The situation was further complicated by the fact that the recirculating cooling water was discharged back into the same river. The objectives of the TRE program were to investigate the causes of toxicity, locate potential sources of the suspected toxicant(s), and identify practicable toxicity reduction methodologies to be used. The TRE program approach and results from the associated studies are presented in this report, including a successful remedy for the WET problem.

  4. 40 CFR 40.165 - Continuation grants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Continuation grants. 40.165 Section 40.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.165 Continuation grants. To be eligible for a continuation...

  5. 40 CFR 40.165 - Continuation grants.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Continuation grants. 40.165 Section 40.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.165 Continuation grants. To be eligible for a continuation...

  6. 40 CFR 40.165 - Continuation grants.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Continuation grants. 40.165 Section 40.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.165 Continuation grants. To be eligible for a continuation...

  7. 40 CFR 40.165 - Continuation grants.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Continuation grants. 40.165 Section 40.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.165 Continuation grants. To be eligible for a continuation...

  8. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use...

  9. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use...

  10. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use...

  11. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use...

  12. 40 CFR 1065.150 - Continuous sampling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Continuous sampling. 1065.150 Section 1065.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use...

  13. 40 CFR 45.155 - Continuation assistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Continuation assistance. 45.155 Section 45.155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE TRAINING ASSISTANCE § 45.155 Continuation assistance. To be eligible for continuation assistance,...

  14. Thermal stress and toxicity.

    PubMed

    Gordon, Christopher J; Johnstone, Andrew F M; Aydin, Cenk

    2014-07-01

    Elevating ambient temperature above thermoneutrality exacerbates toxicity of most air pollutants, insecticides, and other toxic chemicals. On the other hand, safety and toxicity testing of toxicants and drugs is usually performed in mice and rats maintained at sub-thermoneutral temperatures of ~22∘C. When exposed to chemical toxicants under these relatively cool conditions, rodents typically undergo a regulated hypothermic response, characterized by preference for cooler ambient temperatures and controlled reduction in core temperature. Reducing core temperature delays the clearance of most toxicants from the body; however, a mild hypothermia also improves recovery and survival from the toxicant. Raising ambient temperature to thermoneutrality and above increases the rate of clearance of the toxicant but also exacerbates toxicity. Furthermore, heat stress combined with work or exercise is likely to worsen toxicity. Body temperature of large mammals, including humans, does not decrease as much in response to exposure to a toxicant. However, heat stress can nonetheless worsen toxic outcome in humans through a variety of mechanisms. For example, heat-induced sweating and elevation in skin blood flow accelerates uptake of some insecticides. Epidemiological studies suggest that thermal stress may exacerbate the toxicity of airborne pollutants such as ozone and particulate matter. Overall, translating results of studies in rodents to that of humans is a formidable task attributed in part to the interspecies differences in thermoregulatory response to the toxicants and to thermal stress. PMID:24944028

  15. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section...

  16. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section...

  17. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section...

  18. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section...

  19. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  20. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  1. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  2. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  3. 12 CFR 261b.3 - Conduct of agency business.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Conduct of agency business. 261b.3 Section 261b... SYSTEM (CONTINUED) RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.3 Conduct of agency business. Members shall not jointly conduct or dispose of official agency business other than in accordance...

  4. 14 CFR 73.19 - Reports by using agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Reports by using agency. 73.19 Section 73.19 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE SPECIAL USE AIRSPACE Restricted Areas § 73.19 Reports by using agency. (a) Each using agency shall prepare a report on the use of...

  5. 45 CFR 1302.32 - Alternative agency-prohibition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Alternative agency-prohibition. 1302.32 Section 1302.32 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... Alternative agency—prohibition. (a) No agency will be designated as the alternative agency pursuant to...

  6. 45 CFR 1302.32 - Alternative agency-prohibition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Alternative agency-prohibition. 1302.32 Section 1302.32 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... Alternative agency—prohibition. (a) No agency will be designated as the alternative agency pursuant to...

  7. 45 CFR 1302.31 - Requirements of alternative agency.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Requirements of alternative agency. 1302.31 Section 1302.31 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN....31 Requirements of alternative agency. The agency identified by the Indian tribe must establish...

  8. 45 CFR 1302.31 - Requirements of alternative agency.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Requirements of alternative agency. 1302.31 Section 1302.31 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN....31 Requirements of alternative agency. The agency identified by the Indian tribe must establish...

  9. 45 CFR 1302.31 - Requirements of alternative agency.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Requirements of alternative agency. 1302.31 Section 1302.31 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN....31 Requirements of alternative agency. The agency identified by the Indian tribe must establish...

  10. 45 CFR 1302.32 - Alternative agency-prohibition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Alternative agency-prohibition. 1302.32 Section 1302.32 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... Alternative agency—prohibition. (a) No agency will be designated as the alternative agency pursuant to...

  11. 7 CFR 276.2 - State agency liabilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false State agency liabilities. 276.2 Section 276.2 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM STATE AGENCY LIABILITIES AND FEDERAL SANCTIONS § 276.2 State agency liabilities. (a)...

  12. 7 CFR 1216.8 - Farm Service Agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Farm Service Agency or FSA means the U.S. Department of Agriculture's Farm Service Agency. ... 7 Agriculture 10 2011-01-01 2011-01-01 false Farm Service Agency. 1216.8 Section 1216.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE...

  13. 7 CFR 1216.8 - Farm Service Agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Farm Service Agency or FSA means the U.S. Department of Agriculture's Farm Service Agency. ... 7 Agriculture 10 2010-01-01 2010-01-01 false Farm Service Agency. 1216.8 Section 1216.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE...

  14. 34 CFR 303.142 - Designation of lead agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Designation of lead agency. 303.142 Section 303.142 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION....142 Designation of lead agency. Each application must include a designation of the lead agency in...

  15. 5 CFR 831.1307 - Use of consumer reporting agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Use of consumer reporting agencies. 831... REGULATIONS (CONTINUED) RETIREMENT Collection of Debts § 831.1307 Use of consumer reporting agencies. (a... report the debtor to a consumer reporting agency. In addition, a debtor's failure to make...

  16. 5 CFR 831.1307 - Use of consumer reporting agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Use of consumer reporting agencies. 831... REGULATIONS (CONTINUED) RETIREMENT Collection of Debts § 831.1307 Use of consumer reporting agencies. (a... report the debtor to a consumer reporting agency. In addition, a debtor's failure to make...

  17. 5 CFR 831.1307 - Use of consumer reporting agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Use of consumer reporting agencies. 831... REGULATIONS (CONTINUED) RETIREMENT Collection of Debts § 831.1307 Use of consumer reporting agencies. (a... report the debtor to a consumer reporting agency. In addition, a debtor's failure to make...

  18. 5 CFR 831.1307 - Use of consumer reporting agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Use of consumer reporting agencies. 831... REGULATIONS (CONTINUED) RETIREMENT Collection of Debts § 831.1307 Use of consumer reporting agencies. (a... report the debtor to a consumer reporting agency. In addition, a debtor's failure to make...

  19. 7 CFR 4279.115 - Prohibition under Agency programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Prohibition under Agency programs. 4279.115 Section 4279.115 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS... Industry Loans § 4279.115 Prohibition under Agency programs. No B&I loans guaranteed by the Agency will...

  20. 7 CFR 4279.115 - Prohibition under Agency programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Prohibition under Agency programs. 4279.115 Section 4279.115 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS... Industry Loans § 4279.115 Prohibition under Agency programs. No B&I loans guaranteed by the Agency will...

  1. 7 CFR 276.2 - State agency liabilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false State agency liabilities. 276.2 Section 276.2 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM STATE AGENCY LIABILITIES AND FEDERAL SANCTIONS § 276.2 State agency liabilities. Link to...

  2. 75 FR 22184 - Proposed Agency Information Collection Renewal; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... order to inspect and photocopy comments. Board: You may submit comments, which should refer to ``FR TA-1... OTS (collectively, the Banking Agencies or Agencies), as part of their continuing effort to reduce... Reduction Act of 1995. The Banking Agencies may not conduct or sponsor, and the respondent is not...

  3. 38 CFR 45.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Agency and legislative... (CONTINUED) NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 45.200 Agency and legislative liaison... Federal contract, grant, loan, or cooperative agreement if the payment is for agency and...

  4. 34 CFR 303.201 - Designation of lead agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated...

  5. 34 CFR 303.201 - Designation of lead agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated...

  6. 34 CFR 303.201 - Designation of lead agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated...

  7. 34 CFR 303.142 - Designation of lead agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Designation of lead agency. 303.142 Section 303.142 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION....142 Designation of lead agency. Each application must include a designation of the lead agency in...

  8. 40 CFR 166.30 - Notice of Agency decision.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Notice of Agency decision. 166.30 Section 166.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS...

  9. 40 CFR 51.162 - Identification of responsible agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Identification of responsible agency. 51.162 Section 51.162 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Sources and Modifications § 51.162 Identification of responsible agency. Each plan must identify the...

  10. 40 CFR 255.11 - Criteria for identifying agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Criteria for identifying agencies. 255.11 Section 255.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and...

  11. 40 CFR 255.23 - Joint identification of agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Joint identification of agencies. 255.23 Section 255.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Procedures for Identifying Regions and...

  12. 40 CFR 51.162 - Identification of responsible agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Identification of responsible agency. 51.162 Section 51.162 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Sources and Modifications § 51.162 Identification of responsible agency. Each plan must identify the...

  13. 40 CFR 255.11 - Criteria for identifying agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Criteria for identifying agencies. 255.11 Section 255.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and...

  14. 40 CFR 166.30 - Notice of Agency decision.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Notice of Agency decision. 166.30 Section 166.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS...

  15. 40 CFR 255.23 - Joint identification of agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Joint identification of agencies. 255.23 Section 255.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Procedures for Identifying Regions and...

  16. 40 CFR 255.23 - Joint identification of agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Joint identification of agencies. 255.23 Section 255.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Procedures for Identifying Regions and...

  17. 40 CFR 152.110 - Time for agency review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Time for agency review. 152.110 Section 152.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Agency Review of Applications § 152.110 Time for...

  18. 40 CFR 255.23 - Joint identification of agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Joint identification of agencies. 255.23 Section 255.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Procedures for Identifying Regions and...

  19. 40 CFR 255.11 - Criteria for identifying agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Criteria for identifying agencies. 255.11 Section 255.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and...

  20. 40 CFR 161.40 - Consultation with the Agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Consultation with the Agency. 161.40 Section 161.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... with the Agency. This part establishes data requirements applicable to various general use patterns...

  1. 40 CFR 255.23 - Joint identification of agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Joint identification of agencies. 255.23 Section 255.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Procedures for Identifying Regions and...

  2. 40 CFR 51.162 - Identification of responsible agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Identification of responsible agency. 51.162 Section 51.162 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Sources and Modifications § 51.162 Identification of responsible agency. Each plan must identify the...

  3. 40 CFR 152.110 - Time for agency review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Time for agency review. 152.110 Section 152.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Agency Review of Applications § 152.110 Time for...

  4. 40 CFR 255.11 - Criteria for identifying agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Criteria for identifying agencies. 255.11 Section 255.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and...

  5. 40 CFR 51.162 - Identification of responsible agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Identification of responsible agency. 51.162 Section 51.162 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Sources and Modifications § 51.162 Identification of responsible agency. Each plan must identify the...

  6. 40 CFR 166.30 - Notice of Agency decision.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Notice of Agency decision. 166.30 Section 166.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS...

  7. 40 CFR 255.11 - Criteria for identifying agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Criteria for identifying agencies. 255.11 Section 255.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and...

  8. 40 CFR 152.110 - Time for agency review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Time for agency review. 152.110 Section 152.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Agency Review of Applications § 152.110 Time for...

  9. 40 CFR 161.40 - Consultation with the Agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Consultation with the Agency. 161.40 Section 161.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... with the Agency. This part establishes data requirements applicable to various general use patterns...

  10. 40 CFR 161.40 - Consultation with the Agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Consultation with the Agency. 161.40 Section 161.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... with the Agency. This part establishes data requirements applicable to various general use patterns...

  11. 34 CFR 603.24 - Criteria for State agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Criteria for State agencies. 603.24 Section 603.24 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION SECRETARY'S RECOGNITION PROCEDURES FOR STATE AGENCIES Criteria for State Agencies § 603.24 Criteria for...

  12. Accounting for Agency

    ERIC Educational Resources Information Center

    Valentine, Kylie

    2011-01-01

    Children are increasingly described as agents and agency is important to arguments for children's rights and participation. Yet agency is rarely defined or theorised in childhood studies. This article reviews common uses and meanings of agency and argues that critical, social conceptualisations have yet to be extensively taken up in childhood…

  13. 40 CFR 36.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Federal agency or agency. 36.645 Section 36.645 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... Federal agency or agency. Federal agency or agency means any United States executive department,...

  14. 29 CFR 1915.32 - Toxic cleaning solvents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Toxic cleaning solvents. 1915.32 Section 1915.32 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT Surface Preparation and Preservation § 1915.32 Toxic...

  15. 28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Referral of reports where the designated agency is not a law enforcement agency. 81.4 Section 81.4 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is...

  16. 28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Referral of reports where the designated agency is not a law enforcement agency. 81.4 Section 81.4 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is...

  17. STARA (STUDIES ON TOXICITY APPLICABLE TO RISK ASSESSMENT) TOXICITY DATA BASE

    EPA Science Inventory

    The Environmental Criteria and Assessment Office of the U.S. Environmental Protection Agency (EPA) has developed a toxicity data base to aid in the development of risk assessment methodologies and the assessment of health hazards from hazardous waste sites and chemical spills. Th...

  18. The toxicity of inhaled methanol vapors

    SciTech Connect

    Kavet, R.; Nauss, K.M. )

    1990-01-01

    Methanol could become a major automotive fuel in the U.S., and its use may result in increased exposure of the public to methanol vapor. Nearly all of the available information on methanol toxicity in humans relates to the consequences of acute, rather than chronic, exposures. Acute methanol toxicity evolves in a well-understood pattern and consists of an uncompensated metabolic acidosis with superimposed toxicity to the visual system. The toxic properties of methanol are rooted in the factors that govern both the conversion of methanol to formic acid and the subsequent metabolism of formate to carbon dioxide in the folate pathway. In short, the toxic syndrome sets in if formate generation continues at a rate that exceeds its rate of metabolism. Current evidence indicates that formate accumulation will not challenge the metabolic capacity of the folate pathway at the anticipated levels of exposure to automotive methanol vapor.117 references.

  19. The toxicity of inhaled methanol vapors.

    PubMed

    Kavet, R; Nauss, K M

    1990-01-01

    Methanol could become a major automotive fuel in the U.S., and its use may result in increased exposure of the public to methanol vapor. Nearly all of the available information on methanol toxicity in humans relates to the consequences of acute, rather than chronic, exposures. Acute methanol toxicity evolves in a well-understood pattern and consists of an uncompensated metabolic acidosis with superimposed toxicity to the visual system. The toxic properties of methanol are rooted in the factors that govern both the conversion of methanol to formic acid and the subsequent metabolism of formate to carbon dioxide in the folate pathway. In short, the toxic syndrome sets in if formate generation continues at a rate that exceeds its rate of metabolism. Current evidence indicates that formate accumulation will not challenge the metabolic capacity of the folate pathway at the anticipated levels of exposure to automotive methanol vapor. PMID:2264926

  20. Overview of Continuing Education Financing and Budgeting.

    ERIC Educational Resources Information Center

    Shipp, Travis

    1982-01-01

    Continuing education agencies have cycles of financial activities that are all parts of financial management, including obtaining funding and venture capital, setting fees, and controlling costs for cost recovery. (Author/SSH)

  1. Federal Emergency Management Agency Continuing Appropriations Resolution, 2014

    THOMAS, 113th Congress

    Rep. Carter, John R. [R-TX-31

    2013-10-03

    10/07/2013 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 210. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  2. TOXICS RELEASE INVENTORY (TRI)

    EPA Science Inventory

    The Toxics Release Inventory (TRI) site is designed to provide information on toxic chemical releases including collected data, guidance documents, program planning, background, history, and, program contacts, among other things. The data included in this homepage have been submi...

  3. Toxic substances handbook

    NASA Technical Reports Server (NTRS)

    Junod, T. L.

    1979-01-01

    Handbook, published in conjunction with Toxic Substances Alert Program at NASA Lewis Research Center, profiles 187 toxic chemicals in their relatively pure states and include 27 known or suspected carcinogens.

  4. 5 CFR 731.103 - Delegation to agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Delegation to agencies. 731.103 Section 731.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) SUITABILITY Scope § 731.103 Delegation to agencies. (a) Subject to the limitations and requirements of paragraphs (f) and (g) of...

  5. 5 CFR 731.103 - Delegation to agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Delegation to agencies. 731.103 Section 731.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) SUITABILITY Scope § 731.103 Delegation to agencies. (a) Subject to the limitations and requirements of paragraphs (f) and (g) of...

  6. 32 CFR 234.6 - Interfering with agency functions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Interfering with agency functions. 234.6 Section 234.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.6 Interfering with agency functions. The following...

  7. 32 CFR 234.6 - Interfering with agency functions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Interfering with agency functions. 234.6 Section 234.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.6 Interfering with agency functions. The following...

  8. 32 CFR 234.6 - Interfering with agency functions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Interfering with agency functions. 234.6 Section 234.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.6 Interfering with agency functions. The following...

  9. 32 CFR 234.6 - Interfering with agency functions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Interfering with agency functions. 234.6 Section 234.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.6 Interfering with agency functions. The following...

  10. 32 CFR 234.6 - Interfering with agency functions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Interfering with agency functions. 234.6 Section 234.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.6 Interfering with agency functions. The following...

  11. 7 CFR 1944.69 - Agency point of contact.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Agency point of contact. 1944.69 Section 1944.69 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Application Packaging Grants § 1944.69 Agency point...

  12. 40 CFR 82.180 - Agency review of SNAP submissions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Agency review of SNAP submissions. 82.180 Section 82.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Significant New Alternatives Policy Program § 82.180...

  13. 40 CFR 82.180 - Agency review of SNAP submissions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Agency review of SNAP submissions. 82.180 Section 82.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Significant New Alternatives Policy Program § 82.180...

  14. 40 CFR 82.180 - Agency review of SNAP submissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Agency review of SNAP submissions. 82.180 Section 82.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Significant New Alternatives Policy Program § 82.180...

  15. 40 CFR 82.180 - Agency review of SNAP submissions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Agency review of SNAP submissions. 82.180 Section 82.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Significant New Alternatives Policy Program § 82.180...

  16. Psychologic sequelae of chronic toxic waste exposure

    SciTech Connect

    Foulks, E.; McLellen, T. )

    1992-02-01

    Exposure to toxic industrial substances has been a topic of increasing concern to environmentalists, government agencies, industrial engineers, and medical specialists. Our study focuses on the psychologic symptom responses of a community to perceived long-term exposure to toxic waste products. We compared their symptom clusters, as shown by their responses to questions on the Hopkins Symptom Checklist-90 Item (SCL-90) and the Social Adjustment Scale (SAS), with symptom levels of normal and depressed subjects. Issues of media coverage, litigation, and potential for compensation complicate the psychiatric epidemiology of the subject.

  17. How Toxic Is It?

    ERIC Educational Resources Information Center

    Crellin, John R.

    1989-01-01

    Discusses the relative danger from toxicity of some typical chemicals. Notes that some materials in solutions have low toxicity, but in dust form have high toxicity. Suggests that more chemical compounds should be treated as the dangerous compounds they are. Lists common compounds found in the lab. (MVL)

  18. 78 FR 69414 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... October 21, 2011 (76 FR 65385) (FRL-8885-5) (docket ID number EPA-HQ-OPPT-2009-0112). The table in this... AGENCY Toxic Substances Control Act Chemical Testing; Receipt of Test Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces EPA's receipt of test data on...

  19. 77 FR 6801 - Agency for Toxic Substances and Disease Registry; Agency Forms Undergoing Paperwork Reduction Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... housing, FEMA provided over 130,000 travel trailers, park homes, and mobile homes for persons displaced by... the main questionnaire. There are no costs to the respondents other than their time. The total... household members, demographics, and health status questions, focusing on respiratory outcomes and...

  20. 40 CFR 270.51 - Continuation of expiring permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Continuation of expiring permits. 270.51 Section 270.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Expiration and Continuation of Permits § 270.51 Continuation...

  1. Superfund policy fight continues

    SciTech Connect

    Kirschner, E.

    1992-07-29

    Superfund continues to be embroiled in controversy, as companies contend with cleanup costs and Senate amendments seek to cut back municipality and lender liability. The Environmental Protection Agency announced earlier this month that it is suing seven companies for Superfund costs at the Bridgeport Rental and Oil Services waste oil recycling and disposal facility in Logan Township, NJ. EPA says the companies -- Monsanto, DuPont, Allied Signal, Rohm and Haas, Rollings Environmental Services, International Flavors Fragrances, and Atlantic City Electric Power -- as waste generators, should foot the $29 million-plus cleanup bill. At issue is whether the government should be named a potentially responsible party (PRP). Ten PRPs, including four of the firms named in the EPA case, filed a suit in March seeking government involvement in negotiations. DuPont attorney Bernard Reilly says a study of the site shows that 50 million-70 million gal is military waste oil, pegging only 5 million gal as industry's share.

  2. Performance testing of multi-metal continuous emissions monitors

    SciTech Connect

    Haas, W.J.; French, N.B.; Brown, C.H.; Burns, D.B.; Lemieux, P.M.; Ryan, J.V.; Priebe, S.J.; Waterland, L.R.

    1997-11-17

    Three prototype multi-metals continuous emissions monitors (CEMs) were tested in April 1996 at the Rotary Kiln Incinerator Simulator facility at the US Environmental Protection Agency (EPA) National Risk Management Research Laboratory, Research Triangle Park, North Carolina. The CEM instruments were: Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES); Laser Induced Breakdown Spectrometry-Atomic Emission Spectroscopy (LIBS); and Laser Spark Spectrometry, another LIBS instrument. The three CEMs were tested simultaneously during test periods in which low, medium, and high concentration levels of seven toxic metals -- antimony, arsenic, beryllium, cadmium, chromium, lead, and mercury -- were maintained under carefully controlled conditions. Two methods were used to introduce the test metals into the flue gas: (1) solution atomization, introducing metal-containing aerosol directly into the secondary combustion burner, and (2) injection of fly ash particulates. The testing addressed four measures of CEM performance: relative accuracy (RA), calibration drift, zero drift, and response time. These were accomplished by comparing the toxic metal analyte concentrations reported by the CEMs to the concentrations measured using the EPA reference method (RM) for the same analytes. Overall, the test results showed the prototype nature of the test CEMs and the clear need for further development. None of the CEMs tested consistently achieved RA values of 20% or less as required by the EPA draft performance specification. Instrument size reduction and automation will also likely need additional attention before multi-metal CEMs systems become commercially available for service as envisioned by regulators and citizens.

  3. Agency, communion and entitlement.

    PubMed

    Żemojtel-Piotrowska, Magdalena A; Piotrowski, Jarosław P; Clinton, Amanda

    2016-06-01

    In this study, the relationship between agency, communion, and the active, passive, and revenge forms of entitlement is examined. Results indicate that active entitlement was positively related to agency, negatively to communion (Study 1), and unrelated to unmitigated agency and communion (Study 2). Passive entitlement was positively related to communion (in regular and unmitigated forms) and negatively related to agency (in both forms). Revenge entitlement was positively related to agency (unmitigated and regular), and negatively related to both regular and unmitigated communal orientations. Detected relationships were independent from self-esteem (Study 1). The findings are discussed in relation to distinctions between narcissistic and healthy entitlement, and within the context of the three-dimensional model of entitlement. PMID:25594535

  4. 40 CFR 60.1365 - What records must I keep for continuously monitored pollutants or parameters?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY... items: (1) Calendar dates whenever any of the five pollutant or parameter levels recorded in...

  5. 40 CFR 60.1850 - What records must I keep for continuously monitored pollutants or parameters?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY... five pollutant or parameter levels recorded in paragraph (b) of this section or the opacity...

  6. Heavy Metals Toxicity and the Environment

    PubMed Central

    Tchounwou, Paul B; Yedjou, Clement G; Patlolla, Anita K; Sutton, Dwayne J

    2013-01-01

    Heavy metals are naturally occurring elements that have a high atomic weight and a density at least 5 times greater than that of water. Their multiple industrial, domestic, agricultural, medical and technological applications have led to their wide distribution in the environment; raising concerns over their potential effects on human health and the environment. Their toxicity depends on several factors including the dose, route of exposure, and chemical species, as well as the age, gender, genetics, and nutritional status of exposed individuals. Because of their high degree of toxicity, arsenic, cadmium, chromium, lead, and mercury rank among the priority metals that are of public health significance. These metallic elements are considered systemic toxicants that are known to induce multiple organ damage, even at lower levels of exposure. They are also classified as human carcinogens (known or probable) according to the U.S. Environmental Protection Agency, and the International Agency for Research on Cancer. This review provides an analysis of their environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity. PMID:22945569

  7. Heavy metal toxicity and the environment.

    PubMed

    Tchounwou, Paul B; Yedjou, Clement G; Patlolla, Anita K; Sutton, Dwayne J

    2012-01-01

    Heavy metals are naturally occurring elements that have a high atomic weight and a density at least five times greater than that of water. Their multiple industrial, domestic, agricultural, medical, and technological applications have led to their wide distribution in the environment, raising concerns over their potential effects on human health and the environment. Their toxicity depends on several factors including the dose, route of exposure, and chemical species, as well as the age, gender, genetics, and nutritional status of exposed individuals. Because of their high degree of toxicity, arsenic, cadmium, chromium, lead, and mercury rank among the priority metals that are of public health significance. These metallic elements are considered systemic toxicants that are known to induce multiple organ damage, even at lower levels of exposure. They are also classified as human carcinogens (known or probable) according to the US Environmental Protection Agency and the International Agency for Research on Cancer. This review provides an analysis of their environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity. PMID:22945569

  8. 40 CFR 63.7541 - How do I demonstrate continuous compliance under the emission averaging provision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Industrial, Commercial, and Institutional Boilers and Process Heaters Continuous...

  9. 40 CFR 63.7535 - How do I monitor and collect data to demonstrate continuous compliance?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Industrial, Commercial, and Institutional Boilers and Process Heaters Continuous Compliance Requirements § 63.7535 How...

  10. 40 CFR 63.7541 - How do I demonstrate continuous compliance under the emission averaging provision?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Industrial, Commercial, and Institutional Boilers and Process Heaters Continuous...

  11. 42 CFR 431.713 - Continuing study and investigation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Programs for Licensing Nursing Home Administrators § 431.713 Continuing study and investigation. The agency or board must conduct a continuing study of nursing homes and administrators within the State...

  12. 42 CFR 431.713 - Continuing study and investigation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Programs for Licensing Nursing Home Administrators § 431.713 Continuing study and investigation. The agency or board must conduct a continuing study of nursing homes and administrators within the State...

  13. 42 CFR 431.713 - Continuing study and investigation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Programs for Licensing Nursing Home Administrators § 431.713 Continuing study and investigation. The agency or board must conduct a continuing study of nursing homes and administrators within the State...

  14. 78 FR 21245 - Continuity of Operations Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... Environmental Policy Act, Order No. 486, 52 FR 47897 (Dec. 17, 1987), FERC Stats. & Regs. ] 30,783 (1987... Federal Energy Regulatory Commission 18 CFR Part 376 Continuity of Operations Plan AGENCY: Federal Energy... Continuity of Operations Plan regulations to revise its hierarchy of delegation of Commission...

  15. Toxic hazards of underground excavation

    SciTech Connect

    Smith, R.; Chitnis, V.; Damasian, M.; Lemm, M.; Popplesdorf, N.; Ryan, T.; Saban, C.; Cohen, J.; Smith, C.; Ciminesi, F.

    1982-09-01

    Inadvertent intrusion into natural or man-made toxic or hazardous material deposits as a consequence of activities such as mining, excavation or tunnelling has resulted in numerous deaths and injuries in this country. This study is a preliminary investigation to identify and document instances of such fatal or injurious intrusion. An objective is to provide useful insights and information related to potential hazards due to future intrusion into underground radioactive-waste-disposal facilities. The methodology used in this study includes literature review and correspondence with appropriate government agencies and organizations. Key categories of intrusion hazards are asphyxiation, methane, hydrogen sulfide, silica and asbestos, naturally occurring radionuclides, and various mine or waste dump related hazards.

  16. Mass-spectrometer-based continuous emissions monitoring system for acid-gas emissions and DRE demonstration

    NASA Astrophysics Data System (ADS)

    Bartman, Candace D.; Connolly, Erin; Renfroe, Jim; Harlow, George

    1993-03-01

    The objective of the work presented here was to develop a technology for continuous measurement of stack gas emissions for compounds such as HCl, SO2, and NOx that was also capable of monitoring toxic hydrocarbons. The goal was to assure operators and local communities that the emission source is routinely operating in compliance with and well within the U.S. Environmental Protection Agency guidelines. A mass spectrometer-based continuous emissions monitoring system (CEMS) and its sample extraction system developed as a result of this work are described. Results of calibration drift, linearity, and accuracy tests for HCl, SO2, and NOx are presented. Results of CEMS tests are described that show the system has the performance capabilities necessary for a relatively inexpensive and frequent DRE demonstration.

  17. Laser-Induced Breakdown Spectrometry as a Multimetal Continuous-Emission Monitor

    NASA Astrophysics Data System (ADS)

    Zhang, Hansheng; Yueh, Fang-Yu; Singh, Jagdish P.

    1999-03-01

    Laser-induced breakdown spectrometry (LIBS) has been used to detect atomic and molecular species in various environments. LIBS has the capability to be used as a continuous-emission monitor to monitor toxic-metal concentrations in stack emissions. Recently a mobile LIBS system was calibrated in our laboratory and tested as a multimetal continuous-emission monitor during a joint U.S. Department of Energy Environmental Protection Agency (EPA) test. LIBS measurements were performed with three sets of metal concentrations at the EPA Rotary Kiln Incinerator Simulator. The LIBS system successfully measured concentrations of Cr, Pb, Cd, and Be in near real time in this test. Real-time LIBS data were averaged and compared with data obtained from an EPA reference method that was conducted concurrently with LIBS. The details of the LIBS calibration and results of these LIBS measurements are described.

  18. 20 CFR 439.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Federal agency or agency. 439.645 Section 439.645 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 439.645 Federal agency or agency. Federal agency or...

  19. Acute toxicity to goldfish of mixtures of chloramines, copper, and linear alkylate sulfonate

    SciTech Connect

    Tsai, C.F.; McKee, J.A.

    1980-01-01

    The toxicity to goldfish (Carassius auratus) of mixtures of chloramines, copper, and linear alkylate sulfonate (LAS) was studied by continuous-flow toxicity tests during an exposure period of 96 hours. The individual toxicities of these three chemicals are either additive or synergistic in mixtures, depending on the rate of toxic action of the individual chemical, the toxicity ratio of the chemicals in the mixtures, and the concentration of the mixtures.

  20. Title III and toxic torts

    SciTech Connect

    Rodnehausen, G.A.

    1989-07-01

    In July the second annual Toxic Release Inventory (TRI) report under Section 313 of Title III of the Superfund Amendments and Reauthorization Act (SARA), and the computerized, national TRI data-base will be issued. Although the Environmental Protection Agency will not be able to aggregate the July, 1989 reports and issue its own annual report until early next year, we can expect political attention to focus quickly on whether total releases to air, land and water, and in particular total emissions to the air, have increased or decreased from 1987 to 1988. Because the reporting threshold for chemical manufacturing and processing facilities will drop from 75,000 to 50,000 pounds per year, the number of facilities reporting and number of chemicals reported should increase significantly, forcing up total releases. Bringing the totals down will be waste and release reduction efforts already underway in the chemical industry and elsewhere, and perhaps improved accuracy in measurement and estimation of releases. Additions to and deletions from the list of reportable chemicals will also have an effect. Nevertheless, any significant increase in aggregate totals, no matter what the explanation, will be bound to have a political impact on air toxics legislation, and spur public concern with the health risks of air pollution.

  1. 75 FR 8384 - Agency Information Collection Activities: Proposed Collection; Comment Request, 1660-NEW; FEMA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Proposed Collection...: Federal Emergency Management Agency, DHS. ACTION: Notice; 60-day notice and request for comments; new.... SUMMARY: The Federal Emergency Management Agency, as part of its continuing effort to reduce paperwork...

  2. 40 CFR 57.110 - Reimbursement of State or local agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Reimbursement of State or local agency. 57.110 Section 57.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency. As a condition of issuing an NSO, any issuing agency may require the smelter operator to pay...

  3. 40 CFR 51.232 - Assignment of legal authority to local agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Assignment of legal authority to local agencies. 51.232 Section 51.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....232 Assignment of legal authority to local agencies. (a) A State government agency other than...

  4. 40 CFR 57.110 - Reimbursement of State or local agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Reimbursement of State or local agency. 57.110 Section 57.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency. As a condition of issuing an NSO, any issuing agency may require the smelter operator to pay...

  5. 40 CFR 57.110 - Reimbursement of State or local agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Reimbursement of State or local agency. 57.110 Section 57.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency. As a condition of issuing an NSO, any issuing agency may require the smelter operator to pay...

  6. 40 CFR 51.232 - Assignment of legal authority to local agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Assignment of legal authority to local agencies. 51.232 Section 51.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....232 Assignment of legal authority to local agencies. (a) A State government agency other than...

  7. 40 CFR 51.232 - Assignment of legal authority to local agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Assignment of legal authority to local agencies. 51.232 Section 51.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....232 Assignment of legal authority to local agencies. (a) A State government agency other than...

  8. 40 CFR 57.110 - Reimbursement of State or local agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Reimbursement of State or local agency. 57.110 Section 57.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency. As a condition of issuing an NSO, any issuing agency may require the smelter operator to pay...

  9. 40 CFR 57.110 - Reimbursement of State or local agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Reimbursement of State or local agency. 57.110 Section 57.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... agency. As a condition of issuing an NSO, any issuing agency may require the smelter operator to pay...

  10. 40 CFR 51.232 - Assignment of legal authority to local agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Assignment of legal authority to local agencies. 51.232 Section 51.232 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....232 Assignment of legal authority to local agencies. (a) A State government agency other than...

  11. 32 CFR 701.18 - Agency record.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Agency record. 701.18 Section 701.18 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC...

  12. 32 CFR 701.18 - Agency record.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Agency record. 701.18 Section 701.18 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC...

  13. Agencies & vendors. Friends, foes, or partners?

    PubMed

    Miller, L S

    1995-08-01

    Communication is the key to making vendor-agency relationships work. This communication needs to start from the very beginning, with planning, and continue through installation, training, and support. With good communication, the change brought on by automation will be positive. PMID:10151214

  14. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Official agencies. 353.1 Section 353.1 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING DEFINITIVE UNITED STATES SAVINGS BONDS, SERIES EE AND HH General...

  15. 34 CFR 300.33 - Public agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Public agency. 300.33 Section 300.33 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This...

  16. 34 CFR 303.21 - Public agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Public agency. 303.21 Section 303.21 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES General Purpose, Eligibility,...

  17. 7 CFR 1794.33 - Agency action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Agency action. 1794.33 Section 1794.33 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... action. RUS may act on an application for financial assistance upon determining, based on the review...

  18. The Role of the State Approving Agency.

    ERIC Educational Resources Information Center

    Dickinson, Bernell C.

    1987-01-01

    Discusses the role of the State Approving Agency (SAA) in assisting states with their Veterans Education Programs that originated with the G.I. Bill. SAAs continue to help states by providing monitoring services and advising or consulting as needed. (JOW)

  19. 5 CFR 792.105 - Agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (CONTINUED) FEDERAL EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and Drug Abuse Programs and Services for Federal Civilian Employees § 792.105 Agency responsibilities. (a... counseling and referral services can offer and provide employees who have alcohol and/or drug problems...

  20. 7 CFR 981.17 - Inspection agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Inspection agency. 981.17 Section 981.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA...

  1. 7 CFR 981.17 - Inspection agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Inspection agency. 981.17 Section 981.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA...

  2. 7 CFR 981.17 - Inspection agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Inspection agency. 981.17 Section 981.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA...

  3. 7 CFR 981.17 - Inspection agency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Inspection agency. 981.17 Section 981.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA...

  4. 7 CFR 981.17 - Inspection agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Inspection agency. 981.17 Section 981.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA...

  5. 31 CFR 208.7 - Agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Agency responsibilities. 208.7 Section 208.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE FISCAL SERVICE MANAGEMENT OF FEDERAL...

  6. 31 CFR 306.1 - Official agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... securities and requests for appropriate forms may be addressed to the Division of Customer Service... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Official agencies. 306.1 Section 306.1 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL...

  7. Environmental complex mixture toxicity assessment.

    PubMed Central

    Gardner, H S; Brennan, L M; Toussaint, M W; Rosencrance, A B; Boncavage-Hennessey, E M; Wolfe, M J

    1998-01-01

    Trichloroethylene (TCE) was found as a contaminant in the well supplying water to an aquatic testing laboratory. The groundwater was routinely screened by a commercial laboratory for volatile and semivolatile compounds, metals, herbicides, pesticides, and polychlorinated biphenyls using U.S. Environmental Protection Agency methods. Although TCE was the only reportable peak on the gas chromatograph, with average concentrations of 0.200 mg/l, other small peaks were also present, indicating the possibility that the contamination was not limited to TCE alone. A chronic 6-month carcinogenicity assay was conducted on-site in a biomonitoring trailer, using the Japanese medaka fish (Oryzias latipes) in an initiation-promotion protocol, with diethylnitrosamine (DEN) as the initiator and the TCE-contaminated groundwater as a promoter. Study results indicated no evidence of carcinogenic potential of the groundwater without initiation. There was, however, a tumor-promotional effect of the groundwater after DEN initiation. A follow-up laboratory study was conducted using reagent grade TCE added to carbon-filtered groundwater to simulate TCE concentrations comparable to those found in the contaminated groundwater. Study results indicated no promotional effects of TCE. These studies emphasize the necessity for on-site bioassays to assess potential environmental hazards. In this instance, chemical analysis of the groundwater identified TCE as the only reportable contaminant, but other compounds present below reportable limits were noted and may have had a synergistic effect on tumor promotion observed with the groundwater exposure. Laboratory toxicity testing of single compounds can produce toxicity data specific to that compound for that species but cannot take into account the possible toxic effects of mixtures of compounds. Images Figure 2 PMID:9860885

  8. 40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other... requested by the air permitting authority or designated agency. (c) For 40 CFR part 70 or part 71...

  9. 40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other... requested by the air permitting authority or designated agency. (c) For 40 CFR part 70 or part 71...

  10. 40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other... requested by the air permitting authority or designated agency. (c) For 40 CFR part 70 or part 71...

  11. 40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other... requested by the air permitting authority or designated agency. (c) For 40 CFR part 70 or part 71...

  12. 40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other... requested by the air permitting authority or designated agency. (c) For 40 CFR part 70 or part 71...

  13. Smoke toxicity methodology

    NASA Technical Reports Server (NTRS)

    Dilley, J. V.; Martin, S. B.; Mckee, R.; Pryor, G.

    1978-01-01

    The toxicity of pyrolysis products for aircraft interior materials must be within some reasonable limit. The toxicity of pyrolysis products from five candidate aircraft materials is evaluated. The most important part of this study was to demonstrate that pyrolysis of materials could be controlled and biological endpoints are reproducible.

  14. 76 FR 41260 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... collection requests under review by the Office of Management and Budget (OMB) in compliance with the... Officer, Office of Management and Budget, Washington, DC 20503 or by fax to (202) 395- 5806. Written...--National Center for Environmental Health (NCEH) and Agency for Toxic Substances and Disease Registry...

  15. Ammonia and sediment toxicity

    SciTech Connect

    Ogle, R.S.; Hansen, S.R.

    1994-12-31

    Ammonia toxicity to aquatic organisms has received considerable study, with most of these studies focusing on water column organisms. However, with the development and implementation of sediment (and pore water) toxicity tests, the toxicity of ammonia to benthic infauna and other sediment toxicity test organisms has become important, especially since sediment/porewater ammonia occurs at higher concentrations than in the water column. Unfortunately, there has been very little of this type information, especially for marine/estuarine organisms. This laboratory determined the toxicity of ammonia to three key marine/estuarine test organisms: the amphipod Eohaustorius estuarius, the bivalve Mytilus edulis, and the echinoderm Strongylocentrotus purpuratus. Because sediment/porewater pH can differ substantially from typical seawater pH, the toxicity evaluations covered a range of pH levels (6, 7, 8, and 9). Eohaustorius results indicate that while Total Ammonia increased in toxicity (measured as EC50) as pH increased (from 460 mg/L at pH 6, to 13 mg/L at pH 9), unionized ammonia toxicity decreased from 0.13 mg/L at pH 6 to 2.8 mg/L at pH 9. The amphipod was much less sensitive to ammonia than were the bivalve and echinoderm, with an unionized ammonia EC50 at pH 8 of 2.14 mg/L relative to 0.43 mg/L for the mussel and 0.13 mg/L for the purple urchin. These results are discussed with respect to design and interpretation of sediment toxicity test results, including an interpretation approach based on partitioning of Toxic Units (TU).

  16. ACUTE AND CHRONIC TOXICITY STUDIES WITH MONOCHLOROBENZENE IN RAINBOW TROUT

    EPA Science Inventory

    The toxicity of monochlorobenzene (CB) was investigated in rainbow trout following acute intraperitoneal (i.p.) administration and chronic exposure via the water in a continuously flowing system for 15 or 30 days. In the acute study overt toxicity and hepatotoxicity was monitored...

  17. 75 FR 64722 - Agency Information Collection Activities; Proposed Collection; Comment Request; Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Requirements for the Approval and Delegation of Federal Air Toxics Programs to State, Territorial, Local, and... seq.), this document announces that EPA is planning to submit a request to renew an existing approved... and Delegation of Federal Air Toxics Programs to State, Territorial, Local, and Tribal Agencies....

  18. Development of oil product toxicity benchmarks using SSDs

    EPA Science Inventory

    Determining the sensitivity of a diversity of species to spilled oil and chemically dispersed oil continues to be a significant challenge in spill response and impact assessment. We developed species sensitivity distributions (SSDs) of acute toxicity values using standardized te...

  19. TERATOGENESIS, TOXICITY, AND BIOCONCENTRATION IN FROGS EXPOSED TO DIELDRIN

    EPA Science Inventory

    Teratogenesis, acute and chronic toxicity, and bioconcentration were investigated in various like stages of African clawed frogs (Xenopus laevis), bullfrogs (Rana catesbeiana) and leopard frogs (Rana pipiens) exposed to aqueous dieldrin in static-renewal and continuous-flow tests...

  20. Continuous emission monitor for incinerators

    SciTech Connect

    Demirgian, J.

    1992-01-01

    This paper describes the development of Fourier transform infrared (FTIR) spectroscopy to continuous monitoring of incinerator emissions. Fourier transform infrared spectroscopy is well suited to this application because it can identify and quantify selected target analytes in a complex mixture without first separating the components in the mixture. Currently, there is no on-stream method to determine the destruction of hazardous substances, such as benzene, or to continuously monitor for hazardous products of incomplete combustion (PICs) in incinerator exhaust emissions. This capability is especially important because of Federal regulations in the Clean Air Act of 1990, which requires the monitoring of air toxics (Title III), the Resource Conservation and Recovery Act (RCRA), and the Toxic Substances Control Act (TSCA). An on-stream continuous emission monitor (CEM) that can differentiate species in the ppm and ppb range and can calculate the destruction and removal efficiency (DRE) could be used to determine the safety and reliability of incinerators. This information can be used to address reasonable public concern about incinerator safety and aid in the permitting process.

  1. Continuous emission monitor for incinerators

    SciTech Connect

    Demirgian, J.

    1992-07-01

    This paper describes the development of Fourier transform infrared (FTIR) spectroscopy to continuous monitoring of incinerator emissions. Fourier transform infrared spectroscopy is well suited to this application because it can identify and quantify selected target analytes in a complex mixture without first separating the components in the mixture. Currently, there is no on-stream method to determine the destruction of hazardous substances, such as benzene, or to continuously monitor for hazardous products of incomplete combustion (PICs) in incinerator exhaust emissions. This capability is especially important because of Federal regulations in the Clean Air Act of 1990, which requires the monitoring of air toxics (Title III), the Resource Conservation and Recovery Act (RCRA), and the Toxic Substances Control Act (TSCA). An on-stream continuous emission monitor (CEM) that can differentiate species in the ppm and ppb range and can calculate the destruction and removal efficiency (DRE) could be used to determine the safety and reliability of incinerators. This information can be used to address reasonable public concern about incinerator safety and aid in the permitting process.

  2. 77 FR 6557 - Agency Information Collection Activities: Request for Comments on One Proposed Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... AGENCY Agency Information Collection Activities: Request for Comments on One Proposed Information... planning to submit the following one existing, approved, continuing Information Collection Requests (ICR... by one of the following methods: (a) Electronic Submission: Access http://www.regulations.gov...

  3. 75 FR 71718 - Agency Information Collection Activities: Proposed Collection; Comment Request, OMB No. 1660-0011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ...; Comment Request, OMB No. 1660-0011; Debt Collection Financial Statement AGENCY: Federal Emergency... Collection Financial Statement. SUMMARY: The Federal Emergency Management Agency, as part of its continuing... Title: Debt Collection Financial Statement. Type of Information Collection: Revision of a...

  4. THE ART OF DATA MINING THE MINEFIELDS OF TOXICITY DATABASES TO LINK CHEMISTRY TO BIOLOGY

    EPA Science Inventory

    Toxicity databases have a special role in predictive toxicology, providing ready access to historical information throughout the workflow of discovery, development, and product safety processes in drug development as well as in review by regulatory agencies. To provide accurate i...

  5. Compilation of International Regulatory Guidance Documents for Neuropathology Assessment during Nonclinical Toxicity Studies

    EPA Science Inventory

    Neuropathology analysis as an endpoint during nonclinical efficacy and toxicity studies is a challenging prospect that requires trained personnel and particular equipment to achieve optimal results. Accordingly, many regulatory agencies have produced explicit guidelines for desig...

  6. COMPARING THE RECOMMENDED DIETARY ALLOWANCE TO TOXICITY VALUES FOR ZN, SE, MN, AND MB

    EPA Science Inventory

    Certain essential nutrients can be toxic when ingested at dosages higher than the daily nutritional requirement. Research data for the essential trace elements, zinc, selenium, manganese and molybdenum have been reviewed by various government agencies for both their nutritional n...

  7. The threat at home: Confronting the toxic legacy of the US military

    SciTech Connect

    Shulman, S.

    1992-01-01

    The author, using personal impressions, information from goverment and watchdog agency documents, and interviews with military officers, local elected officials, and residents, produces a comprehensive account of the U.S. military's toxic waste stream.

  8. ENVIRONMENTAL TOXICANTS AND DISRUPTED MAMMARY GLAND DEVELOPMENT: THE WINDOW OF SUSCEPTIBILITY

    EPA Science Inventory

    Environmental Toxicants and Altered Mammary Gland Development: The window of susceptibility. Suzanne E. Fenton, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711

    There are several enviro...

  9. ENVIRONMENTAL TOXICANTS AND ALTERED MAMMARY GLAND DEVELOPMENT: THE WINDOW OF SUSCEPTIBILITY

    EPA Science Inventory

    Environmental Toxicants and Altered Mammary Gland Development: The window of susceptibility. Suzanne E. Fenton, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711

    There are several environm...

  10. Assessing Nanoparticle Toxicity

    NASA Astrophysics Data System (ADS)

    Love, Sara A.; Maurer-Jones, Melissa A.; Thompson, John W.; Lin, Yu-Shen; Haynes, Christy L.

    2012-07-01

    Nanoparticle toxicology, an emergent field, works toward establishing the hazard of nanoparticles, and therefore their potential risk, in light of the increased use and likelihood of exposure. Analytical chemists can provide an essential tool kit for the advancement of this field by exploiting expertise in sample complexity and preparation as well as method and technology development. Herein, we discuss experimental considerations for performing in vitro nanoparticle toxicity studies, with a focus on nanoparticle characterization, relevant model cell systems, and toxicity assay choices. Additionally, we present three case studies (of silver, titanium dioxide, and carbon nanotube toxicity) to highlight the important toxicological considerations of these commonly used nanoparticles.

  11. Are deep eutectic solvents benign or toxic?

    PubMed

    Hayyan, Maan; Hashim, Mohd Ali; Hayyan, Adeeb; Al-Saadi, Mohammed A; AlNashef, Inas M; Mirghani, Mohamed E S; Saheed, Olorunnisola Kola

    2013-02-01

    In continuation of investigation for environmentally benign protocol for new solvents termed deep eutectic solvents (DESs), it is herein reported results concerning the toxicity and cytotoxicity of choline chloride (ChCl) based DESs with four hydrogen bond donors including glycerine, ethylene glycol, triethylene glycol and urea. The toxicity was investigated using two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity effect was tested using the Artemia salina leach. It was found that there was no toxic effect for the tested DESs on all of the studied bacteria confirming their benign effects on these bacteria. Nevertheless, it was found that the cytotoxicity of DESs was much higher than their individual components (e.g. glycerine, ChCl) indicating that their toxicological behavior is different. For our best knowledge this is the first time that toxicity and cytotoxicity of DESs were studied. The toxicity and cytotoxicity of DESs varied depending on the structure of components. Careful usage of the terms non-toxicity and biodegradability must be considered. More investigation on this matter is required. PMID:23200570

  12. 45 CFR 1303.6 - Successor agencies and officials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 1303.6 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD... agency, office, or official it shall be deemed to apply to any other agency, office, or official...

  13. 42 CFR 431.10 - Single State agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Single State agency. 431.10 Section 431.10 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Single State Agency §...

  14. 42 CFR 488.12 - Effect of survey agency certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of survey agency certification. 488.12... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.12 Effect of survey agency certification. Certifications by the State survey...

  15. 45 CFR 1168.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Agency and legislative liaison. 1168.200 Section 1168.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1168.200 Agency...

  16. 45 CFR 1158.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Agency and legislative liaison. 1158.200 Section 1158.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1158.200 Agency and...

  17. 45 CFR 1158.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Agency and legislative liaison. 1158.200 Section 1158.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1158.200 Agency and...

  18. 45 CFR 1168.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Agency and legislative liaison. 1168.200 Section 1168.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1168.200 Agency...

  19. 45 CFR 1168.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Agency and legislative liaison. 1168.200 Section 1168.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1168.200 Agency...

  20. 45 CFR 1158.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Agency and legislative liaison. 1158.200 Section 1158.200 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NEW RESTRICTIONS ON LOBBYING Activities by Own Employees § 1158.200 Agency and...