34 CFR 303.142 - Designation of lead agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Designation of lead agency. 303.142 Section 303.142 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION....142 Designation of lead agency. Each application must include a designation of the lead agency in the...

13 CFR 105.403 - Designated Agency Ethics Officials.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Designated Agency Ethics Officials... Agency Ethics Officials. The Designated Agency Ethics Official and Alternates administer the program for... advice and counsel regarding matters relating to the Ethics in Government Act of 1978 and its...

13 CFR 105.403 - Designated Agency Ethics Officials.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Designated Agency Ethics Officials... Agency Ethics Officials. The Designated Agency Ethics Official and Alternates administer the program for... advice and counsel regarding matters relating to the Ethics in Government Act of 1978 and its...

13 CFR 105.403 - Designated Agency Ethics Officials.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Designated Agency Ethics Officials... Agency Ethics Officials. The Designated Agency Ethics Official and Alternates administer the program for... advice and counsel regarding matters relating to the Ethics in Government Act of 1978 and its...

13 CFR 105.403 - Designated Agency Ethics Officials.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Designated Agency Ethics Officials... Agency Ethics Officials. The Designated Agency Ethics Official and Alternates administer the program for... advice and counsel regarding matters relating to the Ethics in Government Act of 1978 and its...

13 CFR 105.403 - Designated Agency Ethics Officials.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Designated Agency Ethics Officials... Agency Ethics Officials. The Designated Agency Ethics Official and Alternates administer the program for... advice and counsel regarding matters relating to the Ethics in Government Act of 1978 and its...

34 CFR 303.201 - Designation of lead agency.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated under...

34 CFR 303.201 - Designation of lead agency.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 2 2013-07-01 2013-07-01 false Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated under...

34 CFR 303.201 - Designation of lead agency.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true Designation of lead agency. 303.201 Section 303.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... of lead agency. Each application must include the name of the State lead agency, as designated under...

28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual abuse...

28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual abuse...

28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual abuse...

28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual abuse...

28 CFR 81.4 - Referral of reports where the designated agency is not a law enforcement agency.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.4 Referral of reports where the designated agency is not a law enforcement agency. Where a report of child abuse received by a designated agency that is not a law enforcement agency involves allegations of sexual abuse...

43 CFR 46.220 - How to designate lead agencies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false How to designate lead agencies. 46.220... NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Initiating the NEPA Process § 46.220 How to designate lead agencies. (a) In most cases, the Responsible Official should designate one Federal agency as the lead with...

43 CFR 46.220 - How to designate lead agencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false How to designate lead agencies. 46.220... NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Initiating the NEPA Process § 46.220 How to designate lead agencies. (a) In most cases, the Responsible Official should designate one Federal agency as the lead with...

43 CFR 46.220 - How to designate lead agencies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true How to designate lead agencies. 46.220... NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Initiating the NEPA Process § 46.220 How to designate lead agencies. (a) In most cases, the Responsible Official should designate one Federal agency as the lead with...

43 CFR 46.220 - How to designate lead agencies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false How to designate lead agencies. 46.220... NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Initiating the NEPA Process § 46.220 How to designate lead agencies. (a) In most cases, the Responsible Official should designate one Federal agency as the lead with...

29 CFR 1640.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 1640.13 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... § 1640.13 Agency specific memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect...

29 CFR 1640.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 1640.13 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... § 1640.13 Agency specific memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect...

29 CFR 1640.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 1640.13 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... § 1640.13 Agency specific memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect...

29 CFR 1640.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 1640.13 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... § 1640.13 Agency specific memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect...

49 CFR 659.9 - Designation of oversight agency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... to review by FTA. (b) Exception. States which have designated oversight agencies for purposes of this part before May 31, 2005 are not required to re-designate to FTA. (c) Timing. The state designation of... project between FTA and a rail transit agency within the state's jurisdiction; or (2) Occur before the...

34 CFR 303.500 - Lead agency establishment or designation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Lead agency establishment or designation. 303.500... INFANTS AND TODDLERS WITH DISABILITIES State Administration General § 303.500 Lead agency establishment or designation. Each system must include a single line of responsibility in a lead agency that— (a) Is...

34 CFR 303.500 - Lead agency establishment or designation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Lead agency establishment or designation. 303.500... INFANTS AND TODDLERS WITH DISABILITIES State Administration General § 303.500 Lead agency establishment or designation. Each system must include a single line of responsibility in a lead agency that— (a) Is...

45 CFR 1321.33 - Designation of area agencies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.33 Designation of... area agency on aging is designated, the State shall give right of first refusal to a unit of general...

45 CFR 1321.33 - Designation of area agencies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.33 Designation of... area agency on aging is designated, the State shall give right of first refusal to a unit of general...

45 CFR 1321.33 - Designation of area agencies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.33 Designation of... area agency on aging is designated, the State shall give right of first refusal to a unit of general...

45 CFR 1321.33 - Designation of area agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.33 Designation of... area agency on aging is designated, the State shall give right of first refusal to a unit of general...

Organizing for Teacher Agency in Curricular Co-Design

ERIC Educational Resources Information Center

Severance, Samuel; Penuel, William R.; Sumner, Tamara; Leary, Heather

2016-01-01

Cultural-historical activity theory (CHAT) approaches to intervention aim for transformative agency, that is, collective actions that expand and bring about new possibilities for activity. In this article, we draw on CHAT as a resource for organizing design research that promotes teachers' agency in designing new science curriculum materials. We…

25 CFR 700.509 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 2 2011-04-01 2011-04-01 false Duties of the designated agency ethics official. 700.509... RELOCATION PROCEDURES Employee Responsibility and Conduct § 700.509 Duties of the designated agency ethics official. The Designated Agency Ethics Official shall coordinate and manage the agency's ethics program...

25 CFR 700.509 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Duties of the designated agency ethics official. 700.509... RELOCATION PROCEDURES Employee Responsibility and Conduct § 700.509 Duties of the designated agency ethics official. The Designated Agency Ethics Official shall coordinate and manage the agency's ethics program...

25 CFR 700.509 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Duties of the designated agency ethics official. 700.509... RELOCATION PROCEDURES Employee Responsibility and Conduct § 700.509 Duties of the designated agency ethics official. The Designated Agency Ethics Official shall coordinate and manage the agency's ethics program...

25 CFR 700.509 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 2 2012-04-01 2012-04-01 false Duties of the designated agency ethics official. 700.509... RELOCATION PROCEDURES Employee Responsibility and Conduct § 700.509 Duties of the designated agency ethics official. The Designated Agency Ethics Official shall coordinate and manage the agency's ethics program...

25 CFR 700.509 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false Duties of the designated agency ethics official. 700.509... RELOCATION PROCEDURES Employee Responsibility and Conduct § 700.509 Duties of the designated agency ethics official. The Designated Agency Ethics Official shall coordinate and manage the agency's ethics program...

Transitioning from conceptual design to construction performance specification

NASA Astrophysics Data System (ADS)

Jeffers, Paul; Warner, Mark; Craig, Simon; Hubbard, Robert; Marshall, Heather

2012-09-01

On successful completion of a conceptual design review by a funding agency or customer, there is a transition phase before construction contracts can be placed. The nature of this transition phase depends on the Project's approach to construction and the particular subsystem being considered. There are generically two approaches; project retention of design authority and issuance of build to print contracts, or issuance of subsystem performance specifications with controlled interfaces. This paper relates to the latter where a proof of concept (conceptual or reference design) is translated into performance based sub-system specifications for competitive tender. This translation is not a straightforward process and there are a number of different issues to consider in the process. This paper deals with primarily the Telescope mount and Enclosure subsystems. The main subjects considered in this paper are: • Typical status of design at Conceptual Design Review compared with the desired status of Specifications and Interface Control Documents at Request for Quotation. • Options for capture and tracking of system requirements flow down from science / operating requirements and sub-system requirements, and functional requirements derived from reference design. • Requirements that may come specifically from the contracting approach. • Methods for effective use of reference design work without compromising a performance based specification. • Management of project team's expectation relating to design. • Effects on cost estimates from reference design to actual. This paper is based on experience and lessons learned through this process on both the VISTA and the ATST projects.

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Service; (8) Defense Information Systems Agency; (9) Defense Intelligence Agency; (10) Defense Logistics... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF DEFENSE § 3601.102 Designation of separate agency...

24 CFR 3282.361 - Design Approval Primary Inspection Agency (DAPIA).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Design Approval Primary Inspection... REGULATIONS Primary Inspection Agencies § 3282.361 Design Approval Primary Inspection Agency (DAPIA). (a... manufactured home designs submitted to it by the manufacturer and for assuring that they conform to the...

5 CFR 2638.203 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics...

5 CFR 2638.203 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics...

5 CFR 2638.203 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics...

5 CFR 2638.203 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics...

36 CFR 1010.15 - Actions where lead agency designation is necessary.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Actions where lead agency... ENVIRONMENTAL QUALITY § 1010.15 Actions where lead agency designation is necessary. (a) Consistent with 40 CFR... functional interdependence or geographical proximity, the Trust will seek designation as lead agency for...

36 CFR 907.16 - Actions where lead Agency designation is necessary.

Code of Federal Regulations, 2010 CFR

2010-07-01

... qualifies as one for which the Corporation will seek designation as lead agency, the Corporation will... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Actions where lead Agency... DEVELOPMENT CORPORATION ENVIRONMENTAL QUALITY § 907.16 Actions where lead Agency designation is necessary. (a...

36 CFR 1010.15 - Actions where lead agency designation is necessary.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Actions where lead agency... ENVIRONMENTAL QUALITY § 1010.15 Actions where lead agency designation is necessary. (a) Consistent with 40 CFR... functional interdependence or geographical proximity, the Trust will seek designation as lead agency for...

36 CFR 907.16 - Actions where lead Agency designation is necessary.

Code of Federal Regulations, 2011 CFR

2011-07-01

... qualifies as one for which the Corporation will seek designation as lead agency, the Corporation will... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Actions where lead Agency... DEVELOPMENT CORPORATION ENVIRONMENTAL QUALITY § 907.16 Actions where lead Agency designation is necessary. (a...

36 CFR 907.16 - Actions where lead Agency designation is necessary.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Actions where lead Agency... DEVELOPMENT CORPORATION ENVIRONMENTAL QUALITY § 907.16 Actions where lead Agency designation is necessary. (a... proximity, the Corporation will seek designation as lead agency for those actions that directly relate to...

36 CFR 1010.15 - Actions where lead agency designation is necessary.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Actions where lead agency... ENVIRONMENTAL QUALITY § 1010.15 Actions where lead agency designation is necessary. (a) Consistent with 40 CFR... functional interdependence or geographical proximity, the Trust will seek designation as lead agency for...

36 CFR 907.16 - Actions where lead Agency designation is necessary.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Actions where lead Agency... DEVELOPMENT CORPORATION ENVIRONMENTAL QUALITY § 907.16 Actions where lead Agency designation is necessary. (a... proximity, the Corporation will seek designation as lead agency for those actions that directly relate to...

36 CFR 1010.15 - Actions where lead agency designation is necessary.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Actions where lead agency... ENVIRONMENTAL QUALITY § 1010.15 Actions where lead agency designation is necessary. (a) Consistent with 40 CFR... functional interdependence or geographical proximity, the Trust will seek designation as lead agency for...

76 FR 81955 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0069] Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT) AGENCY: National Protection and Programs Directorate...), Office of Infrastructure Protection (IP), Sector Specific Agency Executive Management Office (SSA EMO...

36 CFR § 907.16 - Actions where lead Agency designation is necessary.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Actions where lead Agency... DEVELOPMENT CORPORATION ENVIRONMENTAL QUALITY § 907.16 Actions where lead Agency designation is necessary. (a... proximity, the Corporation will seek designation as lead agency for those actions that directly relate to...

36 CFR § 1010.15 - Actions where lead agency designation is necessary.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Actions where lead agency... ENVIRONMENTAL QUALITY § 1010.15 Actions where lead agency designation is necessary. (a) Consistent with 40 CFR... functional interdependence or geographical proximity, the Trust will seek designation as lead agency for...

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF DEFENSE § 3601.102 Designation of separate agency... Services University of the Health Sciences. (b) Employees of DoD components not designated as separate...

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF DEFENSE § 3601.102 Designation of separate agency... Services University of the Health Sciences. (b) Employees of DoD components not designated as separate...

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF DEFENSE § 3601.102 Designation of separate agency... Services University of the Health Sciences. (b) Employees of DoD components not designated as separate...

43 CFR 46.220 - How to designate lead agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... document will meet their needs for adoption and application to their related decision(s). (b) In some cases...) In some cases, the Responsible Official may establish a joint lead relationship among several Federal... agencies. (a) In most cases, the Responsible Official should designate one Federal agency as the lead with...

29 CFR 1640.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Agency specific memoranda of understanding. 1640.13 Section 1640.13 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES FOR COORDINATING THE INVESTIGATION OF COMPLAINTS OR CHARGES OF EMPLOYMENT DISCRIMINATION BASED ON...

50 CFR 402.07 - Designation of lead agency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.07 Designation of lead agency. When a...

50 CFR 402.07 - Designation of lead agency.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.07 Designation of lead agency. When a...

50 CFR 402.07 - Designation of lead agency.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.07 Designation of lead agency. When a...

50 CFR 402.07 - Designation of lead agency.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.07 Designation of lead agency. When a...

50 CFR 402.07 - Designation of lead agency.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.07 Designation of lead agency. When a...

15 CFR 923.47 - Designated State agency.

Code of Federal Regulations, 2011 CFR

2011-01-01

... MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Authorities and Organization § 923.47 Designated State... coordinate other State or local programs, plans and/or policies within the coastal zone; (ii) To what extent... management or regulatory authorities affecting the coastal zone presently are administered by the agency; and...

15 CFR 923.47 - Designated State agency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Authorities and Organization § 923.47 Designated State... coordinate other State or local programs, plans and/or policies within the coastal zone; (ii) To what extent... management or regulatory authorities affecting the coastal zone presently are administered by the agency; and...

34 CFR 370.44 - What reporting requirement applies to each designated agency?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION CLIENT... designated agency from clients or client applicants; (d) The number of the requests for advocacy services from clients or client applicants that the designated agency was unable to serve; (e) The reasons that...

Addressing dual agency: getting specific about the expectations of professionalism.

PubMed

Tilburt, Jon C

2014-01-01

Professionalism requires that physicians uphold the best interests of patients while simultaneously insuring just use of health care resources. Current articulations of these obligations like the American Board of Internal Medicine (ABIM) Foundation's Physician Charter do not reconcile how these obligations fit together when they conflict. This is the problem of dual agency. The most common ways of dealing with dual agency: "bunkering"--physicians act as though societal cost issues are not their problem; "bailing"--physicians assume that they are merely agents of society and deliver care typically based on a strongly consequentialist public health ethic; or "balancing"--a vaguely specified attempt to uphold both patient welfare and societal need for judicious resource use simultaneously--all fail. Here I propose how the problem of dual agency might begin to be addressed with rigor and consistency. Without dealing with the dual agency problem and getting more specific about how to reconcile its norms when they conflict, the expectations of professionalism risk being written off as cute, nonbinding aphorisms from the medical profession.

29 CFR 1640.9 - Processing of complaints or charges of employment discrimination filed with a designated agency...

Code of Federal Regulations, 2012 CFR

2012-07-01

... discrimination filed with a designated agency and either a section 504 agency, the EEOC, or both. 1640.9 Section 1640.9 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... and either a section 504 agency, the EEOC, or both. (a) Designated agency processing. A designated...

29 CFR 1640.9 - Processing of complaints or charges of employment discrimination filed with a designated agency...

Code of Federal Regulations, 2014 CFR

2014-07-01

... discrimination filed with a designated agency and either a section 504 agency, the EEOC, or both. 1640.9 Section 1640.9 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... and either a section 504 agency, the EEOC, or both. (a) Designated agency processing. A designated...

29 CFR 1640.9 - Processing of complaints or charges of employment discrimination filed with a designated agency...

Code of Federal Regulations, 2011 CFR

2011-07-01

... discrimination filed with a designated agency and either a section 504 agency, the EEOC, or both. 1640.9 Section 1640.9 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... and either a section 504 agency, the EEOC, or both. (a) Designated agency processing. A designated...

29 CFR 1640.9 - Processing of complaints or charges of employment discrimination filed with a designated agency...

Code of Federal Regulations, 2010 CFR

2010-07-01

... discrimination filed with a designated agency and either a section 504 agency, the EEOC, or both. 1640.9 Section 1640.9 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... and either a section 504 agency, the EEOC, or both. (a) Designated agency processing. A designated...

45 CFR 1321.33 - Designation of area agencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Designation of area agencies. 1321.33 Section 1321.33 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2012 CFR

2012-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2012-10-01 2012-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2013 CFR

2013-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2013-10-01 2013-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2011 CFR

2011-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2011-10-01 2011-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2014 CFR

2014-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2014-10-01 2014-10-01 false Designated State Protection and Advocacy agency...

28 CFR 31.101 - Designation of State agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) of the JJDP Act. States must have available for review a copy of the State law or executive order... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Designation of State agency. 31.101 Section 31.101 Judicial Administration DEPARTMENT OF JUSTICE OJJDP GRANT PROGRAMS Formula Grants Eligible...

29 CFR 1601.74 - Designated and notice agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... businesses or enterprises; and (4) all charges alleging violations of sec. 704(a) or title VII. For these...-management committee” has violated section 704(a) of title VII; and (3) a charge by an individual alleging... 29 Labor 4 2010-07-01 2010-07-01 false Designated and notice agencies. 1601.74 Section 1601.74...

44 CFR 60.25 - Designation, duties, and responsibilities of State Coordinating Agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Designation, duties, and responsibilities of State Coordinating Agencies. 60.25 Section 60.25 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood...

Analysis of agency relationships in the design and implementation process of the equity fund in Madagascar.

PubMed

Honda, Ayako

2015-02-04

There are large gaps in the literature relating to the implementation of user fee policy and fee exemption measures for the poor, particularly on how such schemes are implemented and why many have not produced expected outcomes. In October 2003, Madagascar instituted a user fee exemption policy which established "equity funds" at public health centres, and used medicine sales revenue to subsidise the cost of medicine for the poor. This study examines the policy design and implementation process of the equity fund in Madagascar in an attempt to explore factors influencing the poor equity outcomes of the scheme. This study applied an agency-incentive framework to investigate the equity fund policy design and implementation practices. It analysed agency relationships established during implementation; examined incentive structures given to the agency relationships in the policy design; and considered how incentive structures were shaped and how agents responded in practice. The study employed a case-study approach with in-depth analysis of three equity fund cases in Madagascar's Boeny region. Policy design problems, triggering implementation problems, caused poor equity performance. These problems were compounded by the re-direction of policy objectives by health administrators and strong involvement of the administrators in the implementation of policy. The source of the policy design and implementation failure was identified as a set of principal-agent problems concerning: monitoring mechanisms; facility-based fund management; and the nature and level of community participation. These factors all contributed to the financial performance of the fund receiving greater attention than its ability to financially protect the poor. The ability of exemption policies to protect the poor from user fees can be found in the details of the policy design and implementation; and implications of the policy design and implementation in a specific context determine whether a policy

77 FR 33227 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0069] Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT) AGENCY: National Protection and Programs Directorate...), Office of Infrastructure Protection (IP), Sector Outreach and Programs Division (SOPD), previously named...

24 CFR 3282.362 - Production Inspection Primary Inspection Agencies (IPIAs).

Code of Federal Regulations, 2010 CFR

2010-04-01

... in production which fails to conform to the design or where the design is not specific, to the... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Production Inspection Primary... REGULATIONS Primary Inspection Agencies § 3282.362 Production Inspection Primary Inspection Agencies (IPIAs...

45 CFR 1321.35 - Withdrawal of area agency designation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Withdrawal of area agency designation. 1321.35 Section 1321.35 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS...

41 CFR 101-5.104-5 - Designating agency representatives.

Code of Federal Regulations, 2010 CFR

2010-07-01

... each agency receiving a GSA notice regarding a scheduled feasibility study will be requested to designate one or more officials at the location where the study will be made who may consult with authorized... review of the feasibility of the proposed centralized service shall be made available to GSA through the...

41 CFR 101-5.104-5 - Designating agency representatives.

Code of Federal Regulations, 2011 CFR

2011-07-01

... each agency receiving a GSA notice regarding a scheduled feasibility study will be requested to designate one or more officials at the location where the study will be made who may consult with authorized... review of the feasibility of the proposed centralized service shall be made available to GSA through the...

5 CFR 3501.102 - Designation of separate agency components.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF THE INTERIOR § 3501.102 Designation of separate agency...: A company that conducts activities regulated by the Bureau of Land Management would not be a prohibited source of gifts for an employee of the National Park Service (NPS), unless that company seeks...

5 CFR 3601.102 - Designation of separate agency components.

Code of Federal Regulations, 2010 CFR

2010-01-01

... outside sources and 5 CFR 2635.807 governing teaching, speaking and writing: (1) Armed Services Board of... Services University of the Health Sciences. (b) Employees of DoD components not designated as separate... identifying the DoD employee's agency under 5 CFR 2635.807 governing teaching, speaking and writing. [58 FR...

77 FR 42554 - Agency Information Collection (Application for Fee or Personnel Designation) Activity Under OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... (Application for Fee or Personnel Designation) Activity Under OMB Review AGENCY: Veterans Benefits...: Application for Fee or Personnel Designation, VA Form 26- 6681. OMB Control Number: 2900-0113. Type of Review... the applicant's experience in the real estate valuation field. An agency may not conduct or sponsor...

49 CFR 107.402 - Application for designation as a certification agency.

Code of Federal Regulations, 2013 CFR

2013-10-01

... agency. 107.402 Section 107.402 Transportation Other Regulations Relating to Transportation PIPELINE AND... facilities in so far as they relate to the certification activities and will cooperate in the conduct of such... proof that the applicant has: (i) The ability to review and evaluate design drawings, design and stress...

Correlation of shear design between AASHTO LRFD bridge design specifications and AASHTO Guide Specifications for the LRFD Seismic Bridge Design.

DOT National Transportation Integrated Search

2017-01-05

This report presents the analytical study of the shear capacity of reinforced concrete columns using both the AASHTO LRFD Bridge Design Specifications and the AASHTO Guide Specifications for the LRFD Seismic Bridge Design. The study investigates vari...

Simplified spacecraft vulnerability assessments at component level in early design phase at the European Space Agency's Concurrent Design Facility

NASA Astrophysics Data System (ADS)

Kempf, Scott; Schäfer, Frank K.; Cardone, Tiziana; Ferreira, Ivo; Gerené, Sam; Destefanis, Roberto; Grassi, Lilith

2016-12-01

During recent years, the state-of-the-art risk assessment of the threat posed to spacecraft by micrometeoroids and space debris has been expanded to the analysis of failure modes of internal spacecraft components. This method can now be used to perform risk analyses for satellites to assess various failure levels - from failure of specific sub-systems to catastrophic break-up. This new assessment methodology is based on triple-wall ballistic limit equations (BLEs), specifically the Schäfer-Ryan-Lambert (SRL) BLE, which is applicable for describing failure threshold levels for satellite components following a hypervelocity impact. The methodology is implemented in the form of the software tool Particle Impact Risk and vulnerability Analysis Tool (PIRAT). During a recent European Space Agency (ESA) funded study, the PIRAT functionality was expanded in order to provide an interface to ESA's Concurrent Design Facility (CDF). The additions include a geometry importer and an OCDT (Open Concurrent Design Tool) interface. The new interface provides both the expanded geometrical flexibility, which is provided by external computer aided design (CAD) modelling, and an ease of import of existing data without the need for extensive preparation of the model. The reduced effort required to perform vulnerability analyses makes it feasible for application during early design phase, at which point modifications to satellite design can be undertaken with relatively little extra effort. The integration of PIRAT in the CDF represents the first time that vulnerability analyses can be performed in-session in ESA's CDF and the first time that comprehensive vulnerability studies can be applied cost-effectively in early design phase in general.

Overview of the European Medicines Agency's Development of Product-Specific Bioequivalence Guidelines.

PubMed

Sullivan, Jane O'; Blake, Kevin; Berntgen, Michael; Salmonson, Tomas; Welink, Jan

2017-12-05

The European Medicines Agency's (EMA) product-specific bioequivalence guidelines outline harmonized regulatory requirements for studies to demonstrate bioequivalence for products that may have particular needs due to their pharmacokinetics, in addition to those outlined in general guidance. As such they are potentially very useful to the pharmaceutical industry in the development of generic medicinal products and to regulatory authorities for harmonized decision-making. Since their introduction in 2013, EMA product-specific bioequivalence guidelines continue to increase in number, and as of June 2017, encompass a number of different pharmacotherapeutic groups and pharmaceutical forms. This article further elucidates the processes involved for stakeholders and reviews the Agency's experience with the development of these guidelines, including the scientific issues witnessed with their advancement. A comparison with the United States Food and Drug Administration approach to similar guidelines is also provided. © 2017 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

Design Specifications for Adaptive Real-Time Systems

DTIC Science & Technology

1991-12-01

TICfl \\ E CT E Design Specifications for JAN’\\ 1992 Adaptive Real - Time Systems fl Randall W. Lichota U, Alice H. Muntz - December 1991 \\ \\\\/ 0 / r...268-2056 Technical Report CMU/SEI-91-TR-20 ESD-91-TR-20 December 1991 Design Specifications for Adaptive Real - Time Systems Randall W. Lichota Hughes...Design Specifications for Adaptive Real - Time Systems Abstract: The design specification method described in this report treats a software

32 CFR 319.13 - Specific exemptions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems of...

32 CFR 319.13 - Specific exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems of...

32 CFR 319.13 - Specific exemptions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems of...

32 CFR 319.13 - Specific exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAM DEFENSE INTELLIGENCE AGENCY PRIVACY PROGRAM § 319.13 Specific exemptions. (a) All systems of records maintained by the Director Intelligence Agency shall be exempt from the requirements of 5 U.S.C... has been properly classified. (b) The Director, Defense Intelligence Agency, designated the systems of...

International Education: A Compendium of Federal Agency Programs.

ERIC Educational Resources Information Center

Owens, Becky, Comp.

Federal agency programs in support of international education are summarized in this report. The publication is designed to help readers discover unknown programs, more fully understand more familiar programs, and learn more about specific requirements for agencies where proposals have been unsuccessfully submitted in the past. Focus is directed…

49 CFR 107.402 - Application for designation as an approval or certification agency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... business is in a country other than the United States, a copy of the designation from the Competent Authority of that country delegating to the applicant an approval or designated agency authority for the... include: (i) The ability to review and evaluate design drawings, design and stress calculations; (ii) A...

41 CFR 102-76.20 - What issues must Federal agencies consider in providing site planning and landscape design services?

Code of Federal Regulations, 2012 CFR

2012-01-01

... agencies consider in providing site planning and landscape design services? 102-76.20 Section 102-76.20... What issues must Federal agencies consider in providing site planning and landscape design services? In providing site planning and design services, Federal agencies must— (a) Make the site planning and landscape...

41 CFR 102-76.20 - What issues must Federal agencies consider in providing site planning and landscape design services?

Code of Federal Regulations, 2011 CFR

2011-01-01

... agencies consider in providing site planning and landscape design services? 102-76.20 Section 102-76.20... What issues must Federal agencies consider in providing site planning and landscape design services? In providing site planning and design services, Federal agencies must— (a) Make the site planning and landscape...

41 CFR 102-76.20 - What issues must Federal agencies consider in providing site planning and landscape design services?

Code of Federal Regulations, 2014 CFR

2014-01-01

... agencies consider in providing site planning and landscape design services? 102-76.20 Section 102-76.20... What issues must Federal agencies consider in providing site planning and landscape design services? In providing site planning and design services, Federal agencies must— (a) Make the site planning and landscape...

41 CFR 102-76.20 - What issues must Federal agencies consider in providing site planning and landscape design services?

Code of Federal Regulations, 2013 CFR

2013-07-01

... agencies consider in providing site planning and landscape design services? 102-76.20 Section 102-76.20... What issues must Federal agencies consider in providing site planning and landscape design services? In providing site planning and design services, Federal agencies must— (a) Make the site planning and landscape...

41 CFR 102-76.25 - What standards must Federal agencies meet in providing architectural and interior design services?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Federal agencies meet in providing architectural and interior design services? 102-76.25 Section 102-76.25...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction § 102-76.25 What standards must Federal agencies meet in providing architectural and interior design services...

28 CFR 81.2 - Submission of reports; designation of agencies to receive reports of child abuse.

Code of Federal Regulations, 2011 CFR

2011-07-01

... agencies to receive reports of child abuse. 81.2 Section 81.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.2 Submission of reports; designation of agencies to receive reports of child abuse. Reports of child abuse required by 42...

28 CFR 81.2 - Submission of reports; designation of agencies to receive reports of child abuse.

Code of Federal Regulations, 2013 CFR

2013-07-01

... agencies to receive reports of child abuse. 81.2 Section 81.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.2 Submission of reports; designation of agencies to receive reports of child abuse. Reports of child abuse required by 42...

28 CFR 81.2 - Submission of reports; designation of agencies to receive reports of child abuse.

Code of Federal Regulations, 2014 CFR

2014-07-01

... agencies to receive reports of child abuse. 81.2 Section 81.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.2 Submission of reports; designation of agencies to receive reports of child abuse. Reports of child abuse required by 42...

28 CFR 81.2 - Submission of reports; designation of agencies to receive reports of child abuse.

Code of Federal Regulations, 2012 CFR

2012-07-01

... agencies to receive reports of child abuse. 81.2 Section 81.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.2 Submission of reports; designation of agencies to receive reports of child abuse. Reports of child abuse required by 42...

40 CFR 68.215 - Permit content and air permitting authority or designated agency requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Permit content and air permitting authority or designated agency requirements. 68.215 Section 68.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Other...

41 CFR 102-74.360 - What are the specific accident and fire prevention responsibilities of occupant agencies?

Code of Federal Regulations, 2011 CFR

2011-01-01

... accident and fire prevention responsibilities of occupant agencies? 102-74.360 Section 102-74.360 Public... MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Accident and Fire Prevention § 102-74.360 What are the specific accident and fire prevention responsibilities of occupant agencies...

7 CFR 281.5 - Responsibilities of an Indian tribal organization designated as State agency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... organization designated as State agency. An ITO administering the Food Stamp Program on a reservation shall... that law in the same manner as any other State agency. The ITO may contract certain administrative functions to private organizations as provided in parts 274 and 277. The ITO may not, however, contract...

Food Design Thinking: A Branch of Design Thinking Specific to Food Design

ERIC Educational Resources Information Center

Zampollo, Francesca; Peacock, Matthew

2016-01-01

Is there a need for a set of methods within Design Thinking tailored specifically for the Food Design process? Is there a need for a branch of Design Thinking dedicated to Food Design alone? Chefs are not generally trained in Design or Design Thinking, and we are only just beginning to understand how they ideate and what recourses are available to…

40 CFR 63.1184 - What do I need to know about the design specifications, installation, and operation of a bag leak...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., each compartment or cell must have a bag leak detector. For a negative-pressure or induced-air fabric... design specifications, installation, and operation of a bag leak detection system? 63.1184 Section 63.1184 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

40 CFR 63.1184 - What do I need to know about the design specifications, installation, and operation of a bag leak...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., each compartment or cell must have a bag leak detector. For a negative-pressure or induced-air fabric... design specifications, installation, and operation of a bag leak detection system? 63.1184 Section 63.1184 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

40 CFR 63.1184 - What do I need to know about the design specifications, installation, and operation of a bag leak...

Code of Federal Regulations, 2012 CFR

2012-07-01

..., each compartment or cell must have a bag leak detector. For a negative-pressure or induced-air fabric... design specifications, installation, and operation of a bag leak detection system? 63.1184 Section 63.1184 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

40 CFR 33.406 - May a recipient designate a lead agency for fair share objective negotiation purposes?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false May a recipient designate a lead agency for fair share objective negotiation purposes? 33.406 Section 33.406 Protection of Environment... recipient designate a lead agency for fair share objective negotiation purposes? If an Indian Tribal, State...

41 CFR 102-193.20 - What are the specific agency responsibilities for records management?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are the specific agency responsibilities for records management? 102-193.20 Section 102-193.20 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT...

29 CFR 1960.6 - Designation of agency safety and health officials.

Code of Federal Regulations, 2011 CFR

2011-07-01

... responsibility to represent effectively the interest and support of the agency head in the management and... Order 12196, and this part; (2) An organization, including provision for the designation of safety and... safety and health program at all operational levels; (3) A set of procedures that ensures effective...

5 CFR 5501.102 - Designation of HHS components as separate agencies.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Designation of HHS components as separate agencies. 5501.102 Section 5501.102 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5501...

5 CFR 5501.102 - Designation of HHS components as separate agencies.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Designation of HHS components as separate agencies. 5501.102 Section 5501.102 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5501...

5 CFR 5501.102 - Designation of HHS components as separate agencies.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Designation of HHS components as separate agencies. 5501.102 Section 5501.102 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5501...

5 CFR 5501.102 - Designation of HHS components as separate agencies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Designation of HHS components as separate agencies. 5501.102 Section 5501.102 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5501...

5 CFR 5501.102 - Designation of HHS components as separate agencies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Designation of HHS components as separate agencies. 5501.102 Section 5501.102 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5501...

21 CFR 3.5 - Procedures for identifying the designated agency component.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Research have entered into agreements clarifying product jurisdictional issues. These guidance... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Procedures for identifying the designated agency component. 3.5 Section 3.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN...

21 CFR 3.5 - Procedures for identifying the designated agency component.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Research have entered into agreements clarifying product jurisdictional issues. These guidance... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Procedures for identifying the designated agency component. 3.5 Section 3.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN...

41 CFR 102-76.55 - What sustainable development principles must Federal agencies apply to the siting, design, and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... construction of new facilities, which include— (a) Optimizing site potential; (b) Minimizing non-renewable... development principles must Federal agencies apply to the siting, design, and construction of new facilities... Federal agencies apply to the siting, design, and construction of new facilities? In keeping with the...

41 CFR 102-76.55 - What sustainable development principles must Federal agencies apply to the siting, design, and...

Code of Federal Regulations, 2014 CFR

2014-01-01

... construction of new facilities, which include— (a) Optimizing site potential; (b) Minimizing non-renewable... development principles must Federal agencies apply to the siting, design, and construction of new facilities... Federal agencies apply to the siting, design, and construction of new facilities? In keeping with the...

41 CFR 102-76.55 - What sustainable development principles must Federal agencies apply to the siting, design, and...

Code of Federal Regulations, 2012 CFR

2012-01-01

... construction of new facilities, which include— (a) Optimizing site potential; (b) Minimizing non-renewable... development principles must Federal agencies apply to the siting, design, and construction of new facilities... Federal agencies apply to the siting, design, and construction of new facilities? In keeping with the...

41 CFR 102-76.55 - What sustainable development principles must Federal agencies apply to the siting, design, and...

Code of Federal Regulations, 2013 CFR

2013-07-01

... construction of new facilities, which include— (a) Optimizing site potential; (b) Minimizing non-renewable... development principles must Federal agencies apply to the siting, design, and construction of new facilities... Federal agencies apply to the siting, design, and construction of new facilities? In keeping with the...

URPD: a specific product primer design tool.

PubMed

Chuang, Li-Yeh; Cheng, Yu-Huei; Yang, Cheng-Hong

2012-06-19

Polymerase chain reaction (PCR) plays an important role in molecular biology. Primer design fundamentally determines its results. Here, we present a currently available software that is not located in analyzing large sequence but used for a rather straight-forward way of visualizing the primer design process for infrequent users. URPD (yoUR Primer Design), a web-based specific product primer design tool, combines the NCBI Reference Sequences (RefSeq), UCSC In-Silico PCR, memetic algorithm (MA) and genetic algorithm (GA) primer design methods to obtain specific primer sets. A friendly user interface is accomplished by built-in parameter settings. The incorporated smooth pipeline operations effectively guide both occasional and advanced users. URPD contains an automated process, which produces feasible primer pairs that satisfy the specific needs of the experimental design with practical PCR amplifications. Visual virtual gel electrophoresis and in silico PCR provide a simulated PCR environment. The comparison of Practical gel electrophoresis comparison to virtual gel electrophoresis facilitates and verifies the PCR experiment. Wet-laboratory validation proved that the system provides feasible primers. URPD is a user-friendly tool that provides specific primer design results. The pipeline design path makes it easy to operate for beginners. URPD also provides a high throughput primer design function. Moreover, the advanced parameter settings assist sophisticated researchers in performing experiential PCR. Several novel functions, such as a nucleotide accession number template sequence input, local and global specificity estimation, primer pair redesign, user-interactive sequence scale selection, and virtual and practical PCR gel electrophoresis discrepancies have been developed and integrated into URPD. The URPD program is implemented in JAVA and freely available at http://bio.kuas.edu.tw/urpd/.

Analytics for Knowledge Creation: Towards Epistemic Agency and Design-Mode Thinking

ERIC Educational Resources Information Center

Chen, Bodong; Zhang, Jianwei

2016-01-01

Innovation and knowledge creation call for high-level epistemic agency and design-mode thinking, two competencies beyond the traditional scopes of schooling. In this paper, we discuss the need for learning analytics to support these two competencies, and more broadly, the demand for education for innovation. We ground these arguments on a…

URPD: a specific product primer design tool

PubMed Central

2012-01-01

Background Polymerase chain reaction (PCR) plays an important role in molecular biology. Primer design fundamentally determines its results. Here, we present a currently available software that is not located in analyzing large sequence but used for a rather straight-forward way of visualizing the primer design process for infrequent users. Findings URPD (yoUR Primer Design), a web-based specific product primer design tool, combines the NCBI Reference Sequences (RefSeq), UCSC In-Silico PCR, memetic algorithm (MA) and genetic algorithm (GA) primer design methods to obtain specific primer sets. A friendly user interface is accomplished by built-in parameter settings. The incorporated smooth pipeline operations effectively guide both occasional and advanced users. URPD contains an automated process, which produces feasible primer pairs that satisfy the specific needs of the experimental design with practical PCR amplifications. Visual virtual gel electrophoresis and in silico PCR provide a simulated PCR environment. The comparison of Practical gel electrophoresis comparison to virtual gel electrophoresis facilitates and verifies the PCR experiment. Wet-laboratory validation proved that the system provides feasible primers. Conclusions URPD is a user-friendly tool that provides specific primer design results. The pipeline design path makes it easy to operate for beginners. URPD also provides a high throughput primer design function. Moreover, the advanced parameter settings assist sophisticated researchers in performing experiential PCR. Several novel functions, such as a nucleotide accession number template sequence input, local and global specificity estimation, primer pair redesign, user-interactive sequence scale selection, and virtual and practical PCR gel electrophoresis discrepancies have been developed and integrated into URPD. The URPD program is implemented in JAVA and freely available at http://bio.kuas.edu.tw/urpd/. PMID:22713312

"Roll of Thunder, Hear My Cry": A Culturally Specific, Subversive Concept of Child Agency.

ERIC Educational Resources Information Center

McDowell, Kelly

2002-01-01

Presents a critique of Mildred D. Taylor's "Roll of Thunder, Hear My Cry" with regard to its positioning of the child subject. Proposes that the novel contrasts classic works of children's fiction by following a trajectory of child agency, which is enabled through the novel's racial specificity. Discusses the role of historical…

28 CFR 37.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2012 CFR

2012-07-01

... memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect to enter into a memorandum...

28 CFR 37.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2010 CFR

2010-07-01

... memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect to enter into a memorandum...

28 CFR 37.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2013 CFR

2013-07-01

... memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect to enter into a memorandum...

28 CFR 37.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2011 CFR

2011-07-01

... memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect to enter into a memorandum...

28 CFR 37.13 - Agency specific memoranda of understanding.

Code of Federal Regulations, 2014 CFR

2014-07-01

... memoranda of understanding. When a section 504 agency amends its regulations to make them consistent with title I of the ADA, the EEOC and the individual section 504 agency may elect to enter into a memorandum...

78 FR 51732 - The Food and Drug Administration/European Medicines Agency Orphan Product Designation and Grant...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] The Food and Drug Administration/European Medicines Agency Orphan Product Designation and Grant Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop. The Food and Drug...

46 CFR 162.050-21 - Separator: Design specification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Separator: Design specification. 162.050-21 Section 162.050-21 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-21 Separator: Design specification. (a) A...

46 CFR 162.050-21 - Separator: Design specification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Separator: Design specification. 162.050-21 Section 162.050-21 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-21 Separator: Design specification. (a) A...

77 FR 52744 - Food and Drug Administration/European Medicines Agency Orphan Product Designation and Grant Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Food and Drug Administration/European Medicines Agency Orphan Product Designation and Grant Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of meeting. The Food and Drug Administration's (FDA) Office of Orphan Products Development...

Reconciling Rigour and Impact by Collaborative Research Design: Study of Teacher Agency

ERIC Educational Resources Information Center

Pantic, Nataša

2017-01-01

This paper illustrates a new way of working collaboratively on the development of a methodology for studying teacher agency for social justice. Increasing emphasis of impact on change as a purpose of social research raises questions about appropriate research designs. Large-scale quantitative research framed within externally set parameters has…

A model of collaborative agency and common ground.

PubMed

Kuziemsky, Craig E; Cornett, Janet Alexandra

2013-01-01

As more healthcare delivery is provided via collaborative means there is a need to understand how to design information and communication technologies (ICTs) to support collaboration. Existing research has largely focused on individual aspects of ICT usage and not how they can support the coordination of collaborative activities. In order to understand how we can design ICTs to support collaboration we need to understand how agents, technologies, information and processes integrate while providing collaborative care delivery. Co-agency and common ground have both provided insight about the integration of different entities as part of collaboration practices. However there is still a lack of understanding about how to coordinate the integration of agents, processes and technologies to support collaboration. This paper combines co-agency and common ground to develop a model of collaborative agency and specific categories of common ground to facilitate its coordination.

Modular Integrated Stackable Layers (MISL) 1.1 Design Specification. Design Guideline Document

NASA Technical Reports Server (NTRS)

Yim, Hester J.

2012-01-01

This document establishes the design guideline of the Modular Instrumentation Data Acquisition (MI-DAQ) system in utilization of several designs available in EV. The MI- DAQ provides the options to the customers depending on their system requirements i.e. a 28V interface power supply, a low power battery operated system, a low power microcontroller, a higher performance microcontroller, a USB interface, a Ethernet interface, a wireless communication, various sensor interfaces, etc. Depending on customer's requirements, the each functional board can be stacked up from a bottom level of power supply to a higher level of stack to provide user interfaces. The stack up of boards are accomplished by a predefined and standardized power bus and data bus connections which are included in this document along with other physical and electrical guidelines. This guideline also provides information for a new design options. This specification is the product of a collaboration between NASA/JSC/EV and Texas A&M University. The goal of the collaboration is to open source the specification and allow outside entities to design, build, and market modules that are compatible with the specification. NASA has designed and is using numerous modules that are compatible to this specification. A limited number of these modules will also be released as open source designs to support the collaboration. The released designs are listed in the Applicable Documents.

29 CFR 1640.9 - Processing of complaints or charges of employment discrimination filed with a designated agency...

Code of Federal Regulations, 2013 CFR

2013-07-01

... discrimination filed with a designated agency and either a section 504 agency, the EEOC, or both. 1640.9 Section 1640.9 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES FOR COORDINATING THE INVESTIGATION OF COMPLAINTS OR CHARGES OF EMPLOYMENT DISCRIMINATION BASED ON...

34 CFR 403.100 - What are the requirements for designating a State corrections educational agency to administer...

Code of Federal Regulations, 2010 CFR

2010-07-01

... corrections educational agency to administer the Programs for Criminal Offenders? 403.100 Section 403.100... ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What... § 403.100 What are the requirements for designating a State corrections educational agency to administer...

Reflight certification software design specifications

NASA Technical Reports Server (NTRS)

1984-01-01

The PDSS/IMC Software Design Specification for the Payload Development Support System (PDSS)/Image Motion Compensator (IMC) is contained. The PDSS/IMC is to be used for checkout and verification of the IMC flight hardware and software by NASA/MSFC.

41 CFR 102-74.340 - Who is responsible for monitoring and controlling areas designated for smoking by an agency head...

Code of Federal Regulations, 2010 CFR

2010-07-01

... with proper signage? 102-74.340 Section 102-74.340 Public Contracts and Property Management Federal... designated for smoking by an agency head and for identifying those areas with proper signage? Agency heads... smoking and identifying these areas with proper signage. Suitable, uniform signs reading “Designated...

41 CFR 102-74.340 - Who is responsible for monitoring and controlling areas designated for smoking by an agency head...

Code of Federal Regulations, 2011 CFR

2011-01-01

... with proper signage? 102-74.340 Section 102-74.340 Public Contracts and Property Management Federal... designated for smoking by an agency head and for identifying those areas with proper signage? Agency heads... smoking and identifying these areas with proper signage. Suitable, uniform signs reading “Designated...

41 CFR 102-74.340 - Who is responsible for monitoring and controlling areas designated for smoking by an agency head...

Code of Federal Regulations, 2013 CFR

2013-07-01

... with proper signage? 102-74.340 Section 102-74.340 Public Contracts and Property Management Federal... designated for smoking by an agency head and for identifying those areas with proper signage? Agency heads... smoking and identifying these areas with proper signage. Suitable, uniform signs reading “Designated...

41 CFR 102-74.340 - Who is responsible for monitoring and controlling areas designated for smoking by an agency head...

Code of Federal Regulations, 2014 CFR

2014-01-01

... with proper signage? 102-74.340 Section 102-74.340 Public Contracts and Property Management Federal... designated for smoking by an agency head and for identifying those areas with proper signage? Agency heads... smoking and identifying these areas with proper signage. Suitable, uniform signs reading “Designated...

41 CFR 102-74.340 - Who is responsible for monitoring and controlling areas designated for smoking by an agency head...

Code of Federal Regulations, 2012 CFR

2012-01-01

... with proper signage? 102-74.340 Section 102-74.340 Public Contracts and Property Management Federal... designated for smoking by an agency head and for identifying those areas with proper signage? Agency heads... smoking and identifying these areas with proper signage. Suitable, uniform signs reading “Designated...

78 FR 48940 - Agency Information Collection (Designation of Beneficiary) Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

... Resources and Housing Branch, New Executive Office Building, Room 10235, Washington, DC 20503 (202) 395-7316...-0020.'' SUPPLEMENTARY INFORMATION: Title: Designation of Beneficiary, Government Life Insurance, VA... optional settlement to be used when the Government Life Insurance matures by death. An agency may not...

A compressor designed for the energy research and development agency automotive gas turbine program

NASA Technical Reports Server (NTRS)

Galvas, M. R.

1975-01-01

A centrifugal compressor was designed for a gas turbine powered automobile as part of the Energy Research and Development Agency program to demonstrate emissions characteristics that meet 1978 standards with fuel economy and acceleration which are competitive with conventionally powered vehicles. A backswept impeller was designed for the compressor in order to attain the efficiency goal range required for the objectives of this program. Details of the design and method of flow analysis of the compressor are presented.

Learner Agency within the Design of an EAP Course

ERIC Educational Resources Information Center

Seppälä, Riina

2015-01-01

To meet the demands of today's society and working life, higher education should support the development of learner agency. How the agency of individual learners emerges in university courses and what kind of agency empowers the learners to face new challenges should be considered. In this article, the focus is on learner agency enabled and…

40 CFR 33.406 - May a recipient designate a lead agency for fair share objective negotiation purposes?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false May a recipient designate a lead agency for fair share objective negotiation purposes? 33.406 Section 33.406 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE PARTICIPATION BY DISADVANTAGED BUSINESS ENTERPRISES IN UNITED STATES ENVIRONMENTAL...

10 CFR Appendix B to Subpart D of... - Categorical Exclusions Applicable to Specific Agency Actions

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Categorical Exclusions Applicable to Specific Agency Actions B Appendix B to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING PROCEDURES Typical Classes of Actions Pt. 1021, Subpt. D, App. B Appendix B to Subpart D of Part 1021...

10 CFR Appendix B to Subpart D of... - Categorical Exclusions Applicable to Specific Agency Actions

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Categorical Exclusions Applicable to Specific Agency Actions B Appendix B to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING PROCEDURES Typical Classes of Actions Pt. 1021, Subpt. D, App. B Appendix B to Subpart D of Part 1021...

10 CFR Appendix B to Subpart D of... - Categorical Exclusions Applicable to Specific Agency Actions

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Categorical Exclusions Applicable to Specific Agency Actions B Appendix B to Subpart D of Part 1021 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING PROCEDURES Typical Classes of Actions Pt. 1021, Subpt. D, App. B Appendix B to Subpart D of Part 1021...

46 CFR 162.050-25 - Cargo monitor: Design specification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Cargo monitor: Design specification. 162.050-25 Section 162.050-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-25 Cargo monitor: Design specification. (...

46 CFR 162.050-25 - Cargo monitor: Design specification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Cargo monitor: Design specification. 162.050-25 Section 162.050-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-25 Cargo monitor: Design specification. (...

31 CFR 800.218 - Lead agency.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a review...

31 CFR 800.218 - Lead agency.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a review...

31 CFR 800.218 - Lead agency.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a review...

31 CFR 800.218 - Lead agency.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a review...

28 CFR 81.2 - Submission of reports; designation of agencies to receive reports of child abuse.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Submission of reports; designation of agencies to receive reports of child abuse. 81.2 Section 81.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CHILD ABUSE AND CHILD PORNOGRAPHY REPORTING DESIGNATIONS AND PROCEDURES § 81.2 Submission of...

24 CFR 3282.361 - Design Approval Primary Inspection Agency (DAPIA).

Code of Federal Regulations, 2010 CFR

2010-04-01

... manufactured home designs submitted to it by the manufacturer and for assuring that they conform to the....362 who deal with the design, quality assurance manual, or manufactured homes built to them, and by... submit floor plans and specific information for each manufactured home design or variation which the...

SEPAC flight software detailed design specifications, volume 1

NASA Technical Reports Server (NTRS)

1982-01-01

The detailed design specifications (as built) for the SEPAC Flight Software are defined. The design includes a description of the total software system and of each individual module within the system. The design specifications describe the decomposition of the software system into its major components. The system structure is expressed in the following forms: the control-flow hierarchy of the system, the data-flow structure of the system, the task hierarchy, the memory structure, and the software to hardware configuration mapping. The component design description includes details on the following elements: register conventions, module (subroutines) invocaton, module functions, interrupt servicing, data definitions, and database structure.

Flood type specific construction of synthetic design hydrographs

NASA Astrophysics Data System (ADS)

Brunner, Manuela I.; Viviroli, Daniel; Sikorska, Anna E.; Vannier, Olivier; Favre, Anne-Catherine; Seibert, Jan

2017-02-01

Accurate estimates of flood peaks, corresponding volumes, and hydrographs are required to design safe and cost-effective hydraulic structures. In this paper, we propose a statistical approach for the estimation of the design variables peak and volume by constructing synthetic design hydrographs for different flood types such as flash-floods, short-rain floods, long-rain floods, and rain-on-snow floods. Our approach relies on the fitting of probability density functions to observed flood hydrographs of a certain flood type and accounts for the dependence between peak discharge and flood volume. It makes use of the statistical information contained in the data and retains the process information of the flood type. The method was tested based on data from 39 mesoscale catchments in Switzerland and provides catchment specific and flood type specific synthetic design hydrographs for all of these catchments. We demonstrate that flood type specific synthetic design hydrographs are meaningful in flood-risk management when combined with knowledge on the seasonality and the frequency of different flood types.

41 CFR 102-76.10 - What basic design and construction policy governs Federal agencies?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What basic design and construction policy governs Federal agencies? 102-76.10 Section 102-76.10 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL...

45 CFR 1321.35 - Withdrawal of area agency designation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.35 Withdrawal... established and published by the State agency on aging; or (4) Activities of the area agency are inconsistent...

45 CFR 1321.35 - Withdrawal of area agency designation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.35 Withdrawal... established and published by the State agency on aging; or (4) Activities of the area agency are inconsistent...

45 CFR 1321.35 - Withdrawal of area agency designation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.35 Withdrawal... established and published by the State agency on aging; or (4) Activities of the area agency are inconsistent...

45 CFR 1321.35 - Withdrawal of area agency designation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.35 Withdrawal... established and published by the State agency on aging; or (4) Activities of the area agency are inconsistent...

Surgeon Design Interface for Patient-Specific Concentric Tube Robots

PubMed Central

Morimoto, Tania K.; Greer, Joseph D.; Hsieh, Michael H.; Okamura, Allison M.

2017-01-01

Concentric tube robots have potential for use in a wide variety of surgical procedures due to their small size, dexterity, and ability to move in highly curved paths. Unlike most existing clinical robots, the design of these robots can be developed and manufactured on a patient- and procedure-specific basis. The design of concentric tube robots typically requires significant computation and optimization, and it remains unclear how the surgeon should be involved. We propose to use a virtual reality-based design environment for surgeons to easily and intuitively visualize and design a set of concentric tube robots for a specific patient and procedure. In this paper, we describe a novel patient-specific design process in the context of the virtual reality interface. We also show a resulting concentric tube robot design, created by a pediatric urologist to access a kidney stone in a pediatric patient. PMID:28656124

Surgeon Design Interface for Patient-Specific Concentric Tube Robots.

PubMed

Morimoto, Tania K; Greer, Joseph D; Hsieh, Michael H; Okamura, Allison M

2016-06-01

Concentric tube robots have potential for use in a wide variety of surgical procedures due to their small size, dexterity, and ability to move in highly curved paths. Unlike most existing clinical robots, the design of these robots can be developed and manufactured on a patient- and procedure-specific basis. The design of concentric tube robots typically requires significant computation and optimization, and it remains unclear how the surgeon should be involved. We propose to use a virtual reality-based design environment for surgeons to easily and intuitively visualize and design a set of concentric tube robots for a specific patient and procedure. In this paper, we describe a novel patient-specific design process in the context of the virtual reality interface. We also show a resulting concentric tube robot design, created by a pediatric urologist to access a kidney stone in a pediatric patient.

Strategy and methodology for rank-ordering Virginia state agencies regarding solar attractiveness and identification of specific project possibilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hewett, R.

1997-12-31

This paper describes the strategy and computer processing system that NREL, the Virginia Department of Mines, Minerals and Energy (DMME) and the state energy office, are developing for computing solar attractiveness scores for state agencies and the individual facilities or buildings within each agency. In the case of an agency, solar attractiveness is a measure of that agency`s having a significant number of facilities for which solar has the potential to be promising. In the case of a facility, solar attractiveness is a measure of its potential for being good, economically viable candidate for a solar waste heating system. Virginiamore » State agencies are charged with reducing fossil energy and electricity use and expense. DMME is responsible for working with them to achieve the goals and for managing the state`s energy consumption and cost monitoring program. This is done using the Fast Accounting System for Energy Reporting (FASER) computerized energy accounting and tracking system and database. Agencies report energy use and expenses (by individual facility and energy type) to DMME quarterly. DMME is also responsible for providing technical and other assistance services to agencies and facilities interested in investigating use of solar. Since Virginia has approximately 80 agencies operating over 8,000 energy-consuming facilities and since DMME`s resources are limited, it is interested in being able to determine: (1) on which agencies to focus; (2) specific facilities on which to focus within each high-priority agency; and (3) irrespective of agency, which facilities are the most promising potential candidates for solar. The computer processing system described in this paper computes numerical solar attractiveness scores for the state`s agencies and the individual facilities using the energy use and cost data in the FASER system database and the state`s and NREL`s experience in implementing, testing and evaluating solar water heating systems in commercial

Adapt Design: A Methodology for Enabling Modular Design for Mission Specific SUAS

DTIC Science & Technology

2016-08-24

ADAPT DESIGN: A METHODOLOGY FOR ENABLING MODULAR DESIGN FOR MISSION SPECIFIC SUAS Zachary C. Fisher David Locascio K. Daniel Cooksey...vehicle’s small scale. This paper considers a different approach to SUAS design aimed at addressing this issue. In this approach, a hybrid modular and...Two types of platforms have been identified: scalable platforms where variants are produced by varying scalable design variables, and modular

Formalisms for user interface specification and design

NASA Technical Reports Server (NTRS)

Auernheimer, Brent J.

1989-01-01

The application of formal methods to the specification and design of human-computer interfaces is described. A broad outline of human-computer interface problems, a description of the field of cognitive engineering and two relevant research results, the appropriateness of formal specification techniques, and potential NASA application areas are described.

41 CFR 102-83.120 - What happens if an agency has a need to be in a specific urban area that is not a central city in...

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency has a need to be in a specific urban area that is not a central city in a metropolitan area? 102... is not a central city in a metropolitan area? If an agency has a need to be in a specific urban area that is not a central city in a metropolitan area, then the agency must give first consideration to...

41 CFR 102-83.120 - What happens if an agency has a need to be in a specific urban area that is not a central city in...

Code of Federal Regulations, 2011 CFR

2011-01-01

... agency has a need to be in a specific urban area that is not a central city in a metropolitan area? 102... is not a central city in a metropolitan area? If an agency has a need to be in a specific urban area that is not a central city in a metropolitan area, then the agency must give first consideration to...

5 CFR 5502.105 - Agency procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

5 CFR 5502.105 - Agency procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

5 CFR 5502.105 - Agency procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

5 CFR 5502.105 - Agency procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

5 CFR 5502.105 - Agency procedures.

Code of Federal Regulations, 2012 CFR

2012-01-01

....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

Gateway design specification for fiber optic local area networks

NASA Technical Reports Server (NTRS)

1985-01-01

This is a Design Specification for a gateway to interconnect fiber optic local area networks (LAN's). The internetworking protocols for a gateway device that will interconnect multiple local area networks are defined. This specification serves as input for preparation of detailed design specifications for the hardware and software of a gateway device. General characteristics to be incorporated in the gateway such as node address mapping, packet fragmentation, and gateway routing features are described.

78 FR 13100 - Models for Plant-Specific Adoption of Technical Specifications Task Force Traveler TSTF-535...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... Definition To Address Advanced Fuel Designs,'' Using the Consolidated Line Item Improvement Process AGENCY...-specific adoption using the Consolidated Line Item Improvement Process (CLIIP). Additionally, the NRC staff..., which may be more reactive at shutdown temperatures above 68[emsp14][deg]F. This STS improvement is part...

76 FR 61707 - Agency for Healthcare Research and Quality Agency Information Collection Activities: Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... will provide the grantees with technical assistance regarding research design, data collection, data... Patient grantees will be asked to complete the Annual Survey once a year. This survey is designed to... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Agency...

Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.

PubMed

Sen, Dilara; Keung, Albert J

2018-01-01

The advent of locus-specific protein recruitment technologies has enabled a new class of studies in chromatin biology. Epigenome editors enable biochemical modifications of chromatin at almost any specific endogenous locus. Their locus specificity unlocks unique information including the functional roles of distinct modifications at specific genomic loci. Given the growing interest in using these tools for biological and translational studies, there are many specific design considerations depending on the scientific question or clinical need. Here we present and discuss important design considerations and challenges regarding the biochemical and locus specificities of epigenome editors. These include how to account for the complex biochemical diversity of chromatin; control for potential interdependency of epigenome editors and their resultant modifications; avoid sequestration effects; quantify the locus specificity of epigenome editors; and improve locus specificity by considering concentration, affinity, avidity, and sequestration effects.

28 CFR 35.190 - Designated agencies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... social services, including schools of medicine, dentistry, nursing, and other health-related schools, the operation of health care and social service providers and institutions, including “grass-roots” and... agencies); state and local government support services (e.g., audit, personnel, comptroller, administrative...

28 CFR 0.65a - Litigation involving Environmental Protection Agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.65a Litigation involving Environmental Protection Agency. With respect to any matter assigned to the Environment and Natural Resources Division in... Environment and Natural Resources Division, and such members of his staff as he may specifically designate in...

Design Specification Issues in Time-Series Intervention Models.

ERIC Educational Resources Information Center

Huitema, Bradley E.; McKean, Joseph W.

2000-01-01

Presents examples of egregious errors of interpretation in time-series intervention models and makes recommendations regarding the correct specification of the design matrix. Discusses the profound effects of variants of the slope change variable in the design matrix. (SLD)

Working Notes from the 1992 AAAI Workshop on Automating Software Design. Theme: Domain Specific Software Design

NASA Technical Reports Server (NTRS)

Keller, Richard M. (Editor); Barstow, David; Lowry, Michael R.; Tong, Christopher H.

1992-01-01

The goal of this workshop is to identify different architectural approaches to building domain-specific software design systems and to explore issues unique to domain-specific (vs. general-purpose) software design. Some general issues that cut across the particular software design domain include: (1) knowledge representation, acquisition, and maintenance; (2) specialized software design techniques; and (3) user interaction and user interface.

41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

Code of Federal Regulations, 2010 CFR

2010-07-01

... conditions may my agency authorize transportation of a POV to my post of duty subsequent to the time of my assignment to that post? 302-9.170 Section 302-9.170 Public Contracts and Property Management Federal Travel... the Time of Assignment § 302-9.170 Under what specific conditions may my agency authorize...

41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

Code of Federal Regulations, 2011 CFR

2011-07-01

... conditions may my agency authorize transportation of a POV to my post of duty subsequent to the time of my assignment to that post? 302-9.170 Section 302-9.170 Public Contracts and Property Management Federal Travel... the Time of Assignment § 302-9.170 Under what specific conditions may my agency authorize...

41 CFR 102-76.30 - What seismic safety standards must Federal agencies follow in the design and construction of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What seismic safety standards must Federal agencies follow in the design and construction of Federal facilities? 102-76.30...

41 CFR 102-76.30 - What seismic safety standards must Federal agencies follow in the design and construction of...

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What seismic safety standards must Federal agencies follow in the design and construction of Federal facilities? 102-76.30...

41 CFR 102-76.30 - What seismic safety standards must Federal agencies follow in the design and construction of...

Code of Federal Regulations, 2014 CFR

2014-01-01

... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What seismic safety standards must Federal agencies follow in the design and construction of Federal facilities? 102-76.30...

41 CFR 102-76.30 - What seismic safety standards must Federal agencies follow in the design and construction of...

Code of Federal Regulations, 2012 CFR

2012-01-01

... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What seismic safety standards must Federal agencies follow in the design and construction of Federal facilities? 102-76.30...

41 CFR 102-76.30 - What seismic safety standards must Federal agencies follow in the design and construction of...

Code of Federal Regulations, 2010 CFR

2010-07-01

... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 76-DESIGN AND CONSTRUCTION Design and Construction... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What seismic safety standards must Federal agencies follow in the design and construction of Federal facilities? 102-76.30...

34 CFR 370.7 - What shall the designated agency do to make its services accessible?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What shall the designated agency do to make its services accessible? 370.7 Section 370.7 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION...

U.S. EPA (ENVIRONMENTAL PROTECTION AGENCY) WASTEWATER DISINFECTION RESEARCH PROGRAM EVOLUTION TO A DESIGN MANUAL

EPA Science Inventory

The paper presents the history of the EPA wastewater disinfection research program from the early 1970's until it culminated with the publication of the Process Design Manual in September 1986. The program was elevated to the highest Agency research priority in 1976 with the infu...

Designing timber highway bridge superstructures using AASHTO?LRFD specifications

Treesearch

James P. Wacker; James S. Groenier

2007-01-01

The allowable-stress design methodology that has been used for decades to design timber bridge superstructures is being replaced in the near future. Beginning in October 2007, bridge designers will be required by the Federal Highway Administration (FHWA) to utilize the Load and Resistance Factor Design (LRFD) design specifications published by the American Association...

41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

Code of Federal Regulations, 2013 CFR

2013-07-01

... conditions may my agency authorize transportation of a POV to my post of duty subsequent to the time of my assignment to that post? 302-9.170 Section 302-9.170 Public Contracts and Property Management Federal Travel... Subsequent to the Time of Assignment § 302-9.170 Under what specific conditions may my agency authorize...

41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

Code of Federal Regulations, 2012 CFR

2012-07-01

... conditions may my agency authorize transportation of a POV to my post of duty subsequent to the time of my assignment to that post? 302-9.170 Section 302-9.170 Public Contracts and Property Management Federal Travel... Subsequent to the Time of Assignment § 302-9.170 Under what specific conditions may my agency authorize...

41 CFR 302-9.170 - Under what specific conditions may my agency authorize transportation of a POV to my post of duty...

Code of Federal Regulations, 2014 CFR

2014-07-01

... conditions may my agency authorize transportation of a POV to my post of duty subsequent to the time of my assignment to that post? 302-9.170 Section 302-9.170 Public Contracts and Property Management Federal Travel... Subsequent to the Time of Assignment § 302-9.170 Under what specific conditions may my agency authorize...

34 CFR 367.10 - How does a designated State agency (DSA) apply for an award?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false How does a designated State agency (DSA) apply for an award? 367.10 Section 367.10 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION INDEPENDENT...

34 CFR 367.10 - How does a designated State agency (DSA) apply for an award?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true How does a designated State agency (DSA) apply for an award? 367.10 Section 367.10 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION INDEPENDENT...

77 FR 20026 - Draft Guidance for Industry: Modified Risk Tobacco Product Applications; Availability; Agency...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... appropriate scientific and medical experts, on the design and conduct of studies required for the assessment... functions, including the design and conduct of research, the oversight of specific studies, and the... any time (see 21 CFR 10.115(g)(5)), to ensure that the Agency considers your comment on this draft...

Experimental evaluation and design of unfilled and concrete-filled FRP composite piles : Task 4A : design specifications.

DOT National Transportation Integrated Search

2015-08-01

The overall goal of this project is the experimental evaluation and design of unfilled and concrete-filled FRP composite piles for load-bearing in bridges. This report covers Task 4A, Design Specifications. : Structural design specifications are base...

Specification, Design, and Analysis of Advanced HUMS Architectures

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi

2004-01-01

During the two-year project period, we have worked on several aspects of domain-specific architectures for HUMS. In particular, we looked at using scenario-based approach for the design and designed a language for describing such architectures. The language is now being used in all aspects of our HUMS design. In particular, we have made contributions in the following areas. 1) We have employed scenarios in the development of HUMS in three main areas. They are: (a) To improve reusability by using scenarios as a library indexing tool and as a domain analysis tool; (b) To improve maintainability by recording design rationales from two perspectives - problem domain and solution domain; (c) To evaluate the software architecture. 2) We have defined a new architectural language called HADL or HUMS Architectural Definition Language. It is a customized version of xArch/xADL. It is based on XML and, hence, is easily portable from domain to domain, application to application, and machine to machine. Specifications written in HADL can be easily read and parsed using the currently available XML parsers. Thus, there is no need to develop a plethora of software to support HADL. 3) We have developed an automated design process that involves two main techniques: (a) Selection of solutions from a large space of designs; (b) Synthesis of designs. However, the automation process is not an absolute Artificial Intelligence (AI) approach though it uses a knowledge-based system that epitomizes a specific HUMS domain. The process uses a database of solutions as an aid to solve the problems rather than creating a new design in the literal sense. Since searching is adopted as the main technique, the challenges involved are: (a) To minimize the effort in searching the database where a very large number of possibilities exist; (b) To develop representations that could conveniently allow us to depict design knowledge evolved over many years; (c) To capture the required information that aid the

23 CFR 636.107 - May contracting agencies use geographic preference in Federal-aid design-build or public-private...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false May contracting agencies use geographic preference in Federal-aid design-build or public-private partnership projects? 636.107 Section 636.107 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.107 May contractin...

Analysis of novel low specific speed pump designs

NASA Astrophysics Data System (ADS)

Klas, R.; Pochylý, F.; Rudolf, P.

2014-03-01

Centrifugal pumps with very low specific speed present significant design challenges. Narrow blade channels, large surface area of hub and shroud discs relative to the blade area, and the presence of significant of blade channel vortices are typical features linked with the difficulty to achieve head and efficiency requirements for such designs. This paper presents an investigation of two novel designs of very low specific speed impellers: impeller having blades with very thick trailing edges and impeller with thick trailing edges and recirculating channels, which are bored along the impeller circumference. Numerical simulations and experimental measurements were used to study the flow dynamics of those new designs. It was shown that thick trailing edges suppress local eddies in the blade channels and decrease energy dissipation due to excessive swirling. Furthermore the recirculating channels will increase the circumferential velocity component on impeller outlet thus increasing the specific energy, albeit adversely affecting the hydraulic efficiency. Analysis of the energy dissipation in the volute showed that the number of the recirculating channels, their geometry and location, all have significant impact on the magnitude of dissipated energy and its distribution which in turn influences the shape of the head curve and the stability of the pump operation. Energy dissipation within whole pump interior (blade channels, volute, rotor- stator gaps) was also studied.

Transit safety retrofit package development : architecture and design specifications.

DOT National Transportation Integrated Search

2014-05-01

The Architecture and Design Specifications capture the TRP system architecture and design that fulfills the technical objectives stated in the TRP requirements document. The document begins with an architectural overview that identifies and describes...

Advancing stream restoration design: a science-based approach using data and methodologies from the agencies

Treesearch

Jessica Palazzolo; Joshua Robinson; Phillip Ellis

2016-01-01

Ecosystem restoration design is a relatively new field of work that requires multi-disciplinary expertise in the natural sciences. Although the field is new, federal agencies and public institutions have spent several decades and millions of dollars researching the sciences and methods that underly restoration activities. However, many restoration practitioners are...

Specification and Design of Electrical Flight System Architectures with SysML

NASA Technical Reports Server (NTRS)

McKelvin, Mark L., Jr.; Jimenez, Alejandro

2012-01-01

Modern space flight systems are required to perform more complex functions than previous generations to support space missions. This demand is driving the trend to deploy more electronics to realize system functionality. The traditional approach for the specification, design, and deployment of electrical system architectures in space flight systems includes the use of informal definitions and descriptions that are often embedded within loosely coupled but highly interdependent design documents. Traditional methods become inefficient to cope with increasing system complexity, evolving requirements, and the ability to meet project budget and time constraints. Thus, there is a need for more rigorous methods to capture the relevant information about the electrical system architecture as the design evolves. In this work, we propose a model-centric approach to support the specification and design of electrical flight system architectures using the System Modeling Language (SysML). In our approach, we develop a domain specific language for specifying electrical system architectures, and we propose a design flow for the specification and design of electrical interfaces. Our approach is applied to a practical flight system.

Faculty Agency in Striving University Contexts: Mundane yet Powerful Acts of Agency

ERIC Educational Resources Information Center

Gonzales, Leslie D.

2015-01-01

Drawing from Archer's critical realist theory of agency, this paper has two specific aims. First, the cultural and structural features of one "striving" institution are outlined. Then, I illustrate how faculty members asserted agency inside their striving university in ways intended to disrupt the structures and cultures that striving…

40 CFR 152.95 - Citation of all studies in the Agency's files pertinent to a specific data requirement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROCEDURES Procedures To Ensure Protection of Data Submitters' Rights § 152.95 Citation of all studies in the... requirement. The applicant who selects this cite-all option must submit to the Agency: (a) A general offer to... may be limited to apply only to data pertinent to the specific data requirement(s) for which the cite...

Determination of photovoltaic concentrator optical design specifications using performance modeling

NASA Astrophysics Data System (ADS)

Kerschen, Kevin A.; Levy, Sheldon L.

The strategy used to develop an optical design specification for a 500X concentration photovoltaic module to be used with a 28-percent-efficient concentrator photovoltaic cell is reported. The computer modeling code (PVOPTICS) developed for this purpose, a Fresnel lens design strategy, and optical component specification procedures are described. Comparisons are made between the predicted performance and the measured performance of components fabricated to those specifications. An acrylic lens and a reflective secondary optical element have been tested, showing efficiencies exceeding 88 percent.

SP-Designer: a user-friendly program for designing species-specific primer pairs from DNA sequence alignments.

PubMed

Villard, Pierre; Malausa, Thibaut

2013-07-01

SP-Designer is an open-source program providing a user-friendly tool for the design of specific PCR primer pairs from a DNA sequence alignment containing sequences from various taxa. SP-Designer selects PCR primer pairs for the amplification of DNA from a target species on the basis of several criteria: (i) primer specificity, as assessed by interspecific sequence polymorphism in the annealing regions, (ii) the biochemical characteristics of the primers and (iii) the intended PCR conditions. SP-Designer generates tables, detailing the primer pair and PCR characteristics, and a FASTA file locating the primer sequences in the original sequence alignment. SP-Designer is Windows-compatible and freely available from http://www2.sophia.inra.fr/urih/sophia_mart/sp_designer/info_sp_designer.php. © 2013 John Wiley & Sons Ltd.

46 CFR 162.050-33 - Bilge alarm: Design specification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Bilge alarm: Design specification. 162.050-33 Section 162.050-33 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162...

A Chance for Attributable Agency.

PubMed

Briegel, Hans J; Müller, Thomas

Can we sensibly attribute some of the happenings in our world to the agency of some of the things around us? We do this all the time, but there are conceptual challenges purporting to show that attributable agency, and specifically one of its most important subspecies, human free agency, is incoherent. We address these challenges in a novel way: rather than merely rebutting specific arguments, we discuss a concrete model that we claim positively illustrates attributable agency in an indeterministic setting. The model, recently introduced by one of the authors in the context of artificial intelligence, shows that an agent with a sufficiently complex memory organization can employ indeterministic happenings in a meaningful way. We claim that these considerations successfully counter arguments against the coherence of libertarian (indeterminism-based) free will.

5 CFR 2638.313 - Agency opinions.

Code of Federal Regulations, 2010 CFR

2010-01-01

....313 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Formal Advisory Opinion Service § 2638.313 Agency opinions. If the designated agency ethics official issues a written opinion concerning the application of...

Designing Domain-Specific HUMS Architectures: An Automated Approach

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi; Agarwal, Neha; Kumar, Pramod; Sundaram, Parthiban

2004-01-01

The HUMS automation system automates the design of HUMS architectures. The automated design process involves selection of solutions from a large space of designs as well as pure synthesis of designs. Hence the whole objective is to efficiently search for or synthesize designs or parts of designs in the database and to integrate them to form the entire system design. The automation system adopts two approaches in order to produce the designs: (a) Bottom-up approach and (b) Top down approach. Both the approaches are endowed with a Suite of quantitative and quantitative techniques that enable a) the selection of matching component instances, b) the determination of design parameters, c) the evaluation of candidate designs at component-level and at system-level, d) the performance of cost-benefit analyses, e) the performance of trade-off analyses, etc. In short, the automation system attempts to capitalize on the knowledge developed from years of experience in engineering, system design and operation of the HUMS systems in order to economically produce the most optimal and domain-specific designs.

Predictive Analytics for City Agencies: Lessons from Children's Services.

PubMed

Shroff, Ravi

2017-09-01

Many municipal agencies maintain detailed and comprehensive electronic records of their interactions with citizens. These data, in combination with machine learning and statistical techniques, offer the promise of better decision making, and more efficient and equitable service delivery. However, a data scientist employed by an agency to implement these techniques faces numerous and varied choices that cumulatively can have significant real-world consequences. The data scientist, who may be the only person at an agency equipped to understand the technical complexity of a predictive algorithm, therefore, bears a good deal of responsibility in making judgments. In this perspective, I use a concrete example from my experience of working with New York City's Administration for Children's Services to illustrate the social and technical tradeoffs that can result from choices made in each step of data analysis. Three themes underlie these tradeoffs: the importance of frequent communication between the data scientist, agency leadership, and domain experts; the agency's resources and organizational constraints; and the necessity of an ethical framework to evaluate salient costs and benefits. These themes inform specific recommendations that I provide to guide agencies that employ data scientists and rely on their work in designing, testing, and implementing predictive algorithms.

Functional design specification for the problem data system. [space shuttle

NASA Technical Reports Server (NTRS)

Boatman, T. W.

1975-01-01

The purpose of the Functional Design Specification is to outline the design for the Problem Data System. The Problem Data System is a computer-based data management system designed to track the status of problems and corrective actions pertinent to space shuttle hardware.

Maintenance Training Equipment: Design Specification Based on Instructional System Development. Revision

DTIC Science & Technology

1984-12-01

model pr, vides a method for communicating a specific training equipment design to the procurement office after A"~- ISD ana lysis has est~blished a...maintenance trainer has been identified. The model provides a method by which a training equipment design can be communicated to the System Project Office...ensure * ase of development of procurement specifications and consistency between different documented designs. A completed application of this maodel

40 CFR 255.11 - Criteria for identifying agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... quality management planning agencies designated under section 208 of the Federal Water Pollution Control... State water quality management agencies. (d) Planning objectives will influence agency selection... IDENTIFICATION OF REGIONS AND AGENCIES FOR SOLID WASTE MANAGEMENT Criteria for Identifying Regions and Agencies...

77 FR 56851 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... draft product-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal...

23 CFR 635.105 - Supervising agency.

Code of Federal Regulations, 2012 CFR

2012-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.105 Supervising agency. (a) The STD has responsibility... authorizing performance of the work by a local public agency or other Federal agency. The STD shall be... projects are completed in conformance with approved plans and specifications. (b) Although the STD may...

23 CFR 635.105 - Supervising agency.

Code of Federal Regulations, 2013 CFR

2013-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.105 Supervising agency. (a) The STD has responsibility... authorizing performance of the work by a local public agency or other Federal agency. The STD shall be... projects are completed in conformance with approved plans and specifications. (b) Although the STD may...

23 CFR 635.105 - Supervising agency.

Code of Federal Regulations, 2014 CFR

2014-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.105 Supervising agency. (a) The STD has responsibility... authorizing performance of the work by a local public agency or other Federal agency. The STD shall be... projects are completed in conformance with approved plans and specifications. (b) Although the STD may...

23 CFR 635.105 - Supervising agency.

Code of Federal Regulations, 2011 CFR

2011-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.105 Supervising agency. (a) The STD has responsibility... authorizing performance of the work by a local public agency or other Federal agency. The STD shall be... projects are completed in conformance with approved plans and specifications. (b) Although the STD may...

29 CFR 1604.6 - Employment agencies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... BECAUSE OF SEX § 1604.6 Employment agencies. (a) Section 703(b) of the Civil Rights Act specifically... of sex. The Commission has determined that private employment agencies which deal exclusively with one sex are engaged in an unlawful employment practice, except to the extent that such agencies limit...

24 CFR 578.11 - Unified Funding Agency.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Unified Funding Agency. 578.11... of Care § 578.11 Unified Funding Agency. (a) Becoming a Unified Funding Agency. To become designated as the Unified Funding Agency (UFA) for a Continuum, a collaborative applicant must be selected by...

Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.

PubMed

Alvizo, Oscar; Mittal, Seema; Mayo, Stephen L; Schiffer, Celia A

2012-07-01

HIV-1 protease recognizes and cleaves more than 12 different substrates leading to viral maturation. While these substrates share no conserved motif, they are specifically selected for and cleaved by protease during viral life cycle. Drug resistant mutations evolve within the protease that compromise inhibitor binding but allow the continued recognition of all these substrates. While the substrate envelope defines a general shape for substrate recognition, successfully predicting the determinants of substrate binding specificity would provide additional insights into the mechanism of altered molecular recognition in resistant proteases. We designed a variant of HIV protease with altered specificity using positive computational design methods and validated the design using X-ray crystallography and enzyme biochemistry. The engineered variant, Pr3 (A28S/D30F/G48R), was designed to preferentially bind to one out of three of HIV protease's natural substrates; RT-RH over p2-NC and CA-p2. In kinetic assays, RT-RH binding specificity for Pr3 increased threefold compared to the wild-type (WT), which was further confirmed by isothermal titration calorimetry. Crystal structures of WT protease and the designed variant in complex with RT-RH, CA-p2, and p2-NC were determined. Structural analysis of the designed complexes revealed that one of the engineered substitutions (G48R) potentially stabilized heterogeneous flap conformations, thereby facilitating alternate modes of substrate binding. Our results demonstrate that while substrate specificity could be engineered in HIV protease, the structural pliability of protease restricted the propagation of interactions as predicted. These results offer new insights into the plasticity and structural determinants of substrate binding specificity of the HIV-1 protease. Copyright © 2012 The Protein Society.

78 FR 20925 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

77 FR 35688 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

77 FR 16842 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

33 CFR 230.16 - Lead and cooperating agencies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Lead and cooperating agencies..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.16 Lead and cooperating agencies. Lead agency, joint lead agency, and cooperating agency designation and responsibilities are covered in 40 CFR 1501.5...

33 CFR 230.16 - Lead and cooperating agencies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Lead and cooperating agencies..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.16 Lead and cooperating agencies. Lead agency, joint lead agency, and cooperating agency designation and responsibilities are covered in 40 CFR 1501.5...

33 CFR 230.16 - Lead and cooperating agencies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Lead and cooperating agencies..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.16 Lead and cooperating agencies. Lead agency, joint lead agency, and cooperating agency designation and responsibilities are covered in 40 CFR 1501.5...

33 CFR 230.16 - Lead and cooperating agencies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Lead and cooperating agencies..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.16 Lead and cooperating agencies. Lead agency, joint lead agency, and cooperating agency designation and responsibilities are covered in 40 CFR 1501.5...

33 CFR 230.16 - Lead and cooperating agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Lead and cooperating agencies..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.16 Lead and cooperating agencies. Lead agency, joint lead agency, and cooperating agency designation and responsibilities are covered in 40 CFR 1501.5...

NASIS data base management system: IBM 360 TSS implementation. Volume 4: Program design specifications

NASA Technical Reports Server (NTRS)

1973-01-01

The design specifications for the programs and modules within the NASA Aerospace Safety Information System (NASIS) are presented. The purpose of the design specifications is to standardize the preparation of the specifications and to guide the program design. Each major functional module within the system is a separate entity for documentation purposes. The design specifications contain a description of, and specifications for, all detail processing which occurs in the module. Sub-models, reference tables, and data sets which are common to several modules are documented separately.

A Learning Design Ontology Based on the IMS Specification

ERIC Educational Resources Information Center

Amorim, Ricardo R.; Lama, Manuel; Sanchez, Eduardo; Riera, Adolfo; Vila, Xose A.

2006-01-01

In this paper, we present an ontology to represent the semantics of the IMS Learning Design (IMS LD) specification, a meta-language used to describe the main elements of the learning design process. The motivation of this work relies on the expressiveness limitations found on the current XML-Schema implementation of the IMS LD conceptual model. To…

Agency and Market Area Factors Affecting Home Health Agency Supply Changes

PubMed Central

Porell, Frank W; Liu, Korbin; Brungo, David P

2006-01-01

Objective To use the natural experiment created by the Medicare interim payment system (IPS) to study supply change behavior of home health agencies (HHAs) in local market areas. Data Sources One hundred percent Medicare home health claims for 1996 and 1999, linked with Medicare Provider of Service and Denominator files, and the Area Resource File. Study Design Medicare home health care (HHC) claims data were used to distinguish HHAs that changed the local market supply of Medicare HHC by their market exit or by significant expansion or contraction of their geographic service area between 1996 and 1999 from other HHAs. Multinomial logit models were estimated to analyze how characteristics of agencies and the market areas in which they served were associated with these different agency-level supply changes. Principal Findings Changes in local HHA supply stemming from geographic service area expansions and contractions rivaled those owing to agency closures and market entries. Agencies at greater risk of closure and service area contraction tended to be smaller, newer, freestanding agencies, operating with more visit-intensive practice styles in markets with more competitor agencies. Except for having much less visit-intensive practice styles, similar attributes characterized agencies that increased local supply through service area expansion. Conclusions Supply changes by HHAs largely reflected rational market responses by agencies to significant changes in financial incentives associated with the Medicare IPS. Recently certified agencies were among the most dynamic providers. Supply changes were more likely among agencies operating in more competitive market environments. PMID:16987305

40 CFR 228.6 - Specific criteria for site selection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Specific criteria for site selection. 228.6 Section 228.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN... designation promulgation as an environmental assessment of the impact of the use of the site for disposal, and...

GSP: A web-based platform for designing genome-specific primers in polyploids

USDA-ARS?s Scientific Manuscript database

The sequences among subgenomes in a polyploid species have high similarity. This makes difficult to design genome-specific primers for sequence analysis. We present a web-based platform named GSP for designing genome-specific primers to distinguish subgenome sequences in the polyploid genome backgr...

29 CFR 1601.80 - Certified designated FEP agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... agencies receiving certification by the Commission are as follows: Alaska Commission for Human Rights Alexandria (VA) Human Rights Office Anchorage (AK) Equal Rights Commission Arizona Civil Rights Division Arlington County (VA) Human Rights Commission Austin Human Relations Commission Baltimore (MD) Community...

17 CFR 200.503 - Senior agency official.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Senior agency official. 200... Information and Material § 200.503 Senior agency official. The Executive Director of the Commission is designated the senior agency official responsible for conducting an oversight program to ensure effective...

46 CFR 503.52 - Senior agency official.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Senior agency official. 503.52 Section 503.52 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS PUBLIC INFORMATION Information Security Program § 503.52 Senior agency official. The Chairman of the Commission shall designate a senior agency...

45 CFR 1302.32 - Alternative agency-prohibition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Alternative agency-prohibition. 1302.32 Section 1302.32 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... Alternative agency—prohibition. (a) No agency will be designated as the alternative agency pursuant to this...

Practical Findings from Applying the PSD Model for Evaluating Software Design Specifications

NASA Astrophysics Data System (ADS)

Räisänen, Teppo; Lehto, Tuomas; Oinas-Kukkonen, Harri

This paper presents practical findings from applying the PSD model to evaluating the support for persuasive features in software design specifications for a mobile Internet device. On the one hand, our experiences suggest that the PSD model fits relatively well for evaluating design specifications. On the other hand, the model would benefit from more specific heuristics for evaluating each technique to avoid unnecessary subjectivity. Better distinction between the design principles in the social support category would also make the model easier to use. Practitioners who have no theoretical background can apply the PSD model to increase the persuasiveness of the systems they design. The greatest benefit of the PSD model for researchers designing new systems may be achieved when it is applied together with a sound theory, such as the Elaboration Likelihood Model. Using the ELM together with the PSD model, one may increase the chances for attitude change.

Structured output-feedback controller synthesis with design specifications

NASA Astrophysics Data System (ADS)

Hao, Yuqing; Duan, Zhisheng

2017-03-01

This paper considers the problem of structured output-feedback controller synthesis with finite frequency specifications. Based on the orthogonal space information of input matrix, an improved parameter-dependent Lyapunov function method is first proposed. Then, a two-stage construction method is designed, which depends on an initial centralised controller. Corresponding design conditions for three types of output-feedback controllers are presented in terms of unified representations. Moreover, heuristic algorithms are provided to explore the desirable controllers. Finally, the effectiveness of these proposed methods is illustrated via some practical examples.

29 CFR 1601.80 - Certified designated FEP agencies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Department Palm Beach County Office of Equal Opportunity Pennsylvania Human Relations Commission Philadelphia... Human Resources Rhode Island Commission for Human Rights St. Louis (MO) Civil Rights Enforcement Agency... Attorney General's Office, Civil Rights Division Virgin Islands Department of Labor Washington Human Rights...

Educational Specifications: Linking Design of School Facilities to Educational Program.

ERIC Educational Resources Information Center

California State Dept. of Education, Sacramento. Div. of School Facilities Planning.

The California Department of Education, directed to formalize regulations governing standards for new school design and construction, has prepared a guide to help school districts develop specifications based on the architectural principle that form follows function. This guide discusses the meaning of educational specifications and their…

5 CFR 2641.302 - Separate agency components.

Code of Federal Regulations, 2013 CFR

2013-01-01

... primarily focusing on cancer research. The agency had been designated as a distinct and separate component... Agency for Cancer Research. Approximately 20% of the employees of the former agency are transferred to various other parts of the Department to continue their work on medical research unrelated to cancer. The...

5 CFR 2641.302 - Separate agency components.

Code of Federal Regulations, 2012 CFR

2012-01-01

... primarily focusing on cancer research. The agency had been designated as a distinct and separate component... Agency for Cancer Research. Approximately 20% of the employees of the former agency are transferred to various other parts of the Department to continue their work on medical research unrelated to cancer. The...

5 CFR 2641.302 - Separate agency components.

Code of Federal Regulations, 2014 CFR

2014-01-01

... primarily focusing on cancer research. The agency had been designated as a distinct and separate component... Agency for Cancer Research. Approximately 20% of the employees of the former agency are transferred to various other parts of the Department to continue their work on medical research unrelated to cancer. The...

5 CFR 2641.302 - Separate agency components.

Code of Federal Regulations, 2011 CFR

2011-01-01

... primarily focusing on cancer research. The agency had been designated as a distinct and separate component... Agency for Cancer Research. Approximately 20% of the employees of the former agency are transferred to various other parts of the Department to continue their work on medical research unrelated to cancer. The...

The relationship between social status and the components of agency.

PubMed

Louvet, Eva; Cambon, Laurent; Milhabet, Isabelle; Rohmer, Odile

2018-02-20

Building on the two fundamental dimensions of social judgment distinguishing communion from agency, the purpose of the present work was to show that the strength of the relationship between social status and agency depends on specific components at issue: assertiveness, competence, and effort. Four experimental studies were conducted using two complementary paradigms. In Studies 1 and 2, we manipulated social status, and participants had to rate the target on competence, assertiveness, and effort. In Studies 3 and 4, we reversed the design. Results consistently showed that social status was primarily related to assertiveness, somewhat related to competence, and only slightly related to effort. The present research provides a better understanding of how the dimensions of social judgment are used to explain differences in social status.

De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity

PubMed Central

Boyken, Scott E.; Chen, Zibo; Groves, Benjamin; Langan, Robert A.; Oberdorfer, Gustav; Ford, Alex; Gilmore, Jason; Xu, Chunfu; DiMaio, Frank; Pereira, Jose Henrique; Sankaran, Banumathi; Seelig, Georg; Zwart, Peter H.; Baker, David

2017-01-01

In nature, structural specificity in DNA and proteins is encoded quite differently: in DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar interactions. Here we describe a general approach for designing a wide range of protein homo-oligomers with specificity determined by modular arrays of central hydrogen bond networks. We use the approach to design dimers, trimers, and tetramers consisting of two concentric rings of helices, including previously not seen triangular, square, and supercoiled topologies. X-ray crystallography confirms that the structures overall, and the hydrogen bond networks in particular, are nearly identical to the design models, and the networks confer interaction specificity in vivo. The ability to design extensive hydrogen bond networks with atomic accuracy is a milestone for protein design and enables the programming of protein interaction specificity for a broad range of synthetic biology applications. PMID:27151862

Molecular design of sequence specific DNA alkylating agents.

PubMed

Minoshima, Masafumi; Bando, Toshikazu; Shinohara, Ken-ichi; Sugiyama, Hiroshi

2009-01-01

Sequence-specific DNA alkylating agents have great interest for novel approach to cancer chemotherapy. We designed the conjugates between pyrrole (Py)-imidazole (Im) polyamides and DNA alkylating chlorambucil moiety possessing at different positions. The sequence-specific DNA alkylation by conjugates was investigated by using high-resolution denaturing polyacrylamide gel electrophoresis (PAGE). The results showed that polyamide chlorambucil conjugates alkylate DNA at flanking adenines in recognition sequences of Py-Im polyamides, however, the reactivities and alkylation sites were influenced by the positions of conjugation. In addition, we synthesized conjugate between Py-Im polyamide and another alkylating agent, 1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI). DNA alkylation reactivies by both alkylating polyamides were almost comparable. In contrast, cytotoxicities against cell lines differed greatly. These comparative studies would promote development of appropriate sequence-specific DNA alkylating polyamides against specific cancer cells.

Development of a domain-specific genetic language to design Chlamydomonas reinhardtii expression vectors.

PubMed

Wilson, Mandy L; Okumoto, Sakiko; Adam, Laura; Peccoud, Jean

2014-01-15

Expression vectors used in different biotechnology applications are designed with domain-specific rules. For instance, promoters, origins of replication or homologous recombination sites are host-specific. Similarly, chromosomal integration or viral delivery of an expression cassette imposes specific structural constraints. As de novo gene synthesis and synthetic biology methods permeate many biotechnology specialties, the design of application-specific expression vectors becomes the new norm. In this context, it is desirable to formalize vector design strategies applicable in different domains. Using the design of constructs to express genes in the chloroplast of Chlamydomonas reinhardtii as an example, we show that a vector design strategy can be formalized as a domain-specific language. We have developed a graphical editor of context-free grammars usable by biologists without prior exposure to language theory. This environment makes it possible for biologists to iteratively improve their design strategies throughout the course of a project. It is also possible to ensure that vectors designed with early iterations of the language are consistent with the latest iteration of the language. The context-free grammar editor is part of the GenoCAD application. A public instance of GenoCAD is available at http://www.genocad.org. GenoCAD source code is available from SourceForge and licensed under the Apache v2.0 open source license.

NASIS data base management system - IBM 360/370 OS MVT implementation. 4: Program design specifications

NASA Technical Reports Server (NTRS)

1973-01-01

The design specifications for the programs and modules within the NASA Aerospace Safety Information System (NASIS) are presented. The purpose of the design specifications is to standardize the preparation of the specifications and to guide the program design. Each major functional module within the system is a separate entity for documentation purposes. The design specifications contain a description of, and specifications for, all detail processing which occurs in the module. Sub-modules, reference tables, and data sets which are common to several modules are documented separately.

34 CFR 303.36 - State educational agency.

Code of Federal Regulations, 2014 CFR

2014-07-01

... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... such officer or agency, an officer or agency designated by the Governor or by State law. (b) The term...

34 CFR 303.36 - State educational agency.

Code of Federal Regulations, 2013 CFR

2013-07-01

... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... such officer or agency, an officer or agency designated by the Governor or by State law. (b) The term...

34 CFR 303.36 - State educational agency.

Code of Federal Regulations, 2012 CFR

2012-07-01

... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... such officer or agency, an officer or agency designated by the Governor or by State law. (b) The term...

Minimum Check List for Mechanical and Electrical Plans & Specifications.

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh. Div. of School Facility Services.

This is the fifth revision of the Minimum Check List since its origin in 1960 by North Carolina's School Planning. The checklist was developed to serve as a means of communication between school agencies and design professionals and has been widely used in the development and review of mechanical and electrical plans and specifications by…

Health technology assessment of medical devices: a survey of non-European union agencies.

PubMed

Ciani, Oriana; Wilcher, Britni; Blankart, Carl Rudolf; Hatz, Maximilian; Rupel, Valentina Prevolnik; Erker, Renata Slabe; Varabyova, Yauheniya; Taylor, Rod S

2015-01-01

The aim of this study was to review and compare current health technology assessment (HTA) activities for medical devices across non-European Union HTA agencies. HTA activities for medical devices were evaluated from three perspectives: organizational structure, processes, and methods. Agencies were primarily selected upon membership of existing HTA networks. The data collection was performed in two stages: stage 1-agency Web-site assessment using a standardized questionnaire, followed by review and validation of the collected data by a representative of the agency; and stage 2-semi-structured telephone interviews with key informants of a sub-sample of agencies. In total, thirty-six HTA agencies across twenty non-EU countries assessing medical devices were included. Twenty-seven of thirty-six (75 percent) agencies were judged at stage 1 to have adopted HTA-specific approaches for medical devices (MD-specific agencies) that were largely organizational or procedural. There appeared to be few differences in the organization, process and methods between MD-specific and non-MD-specific agencies. Although the majority (69 percent) of both categories of agency had specific methods guidance or policy for evidence submission, only one MD-specific agency had developed methodological guidelines specific to medical devices. In stage 2, many MD-specific agencies cited insufficient resources (budget, skilled employees), lack of coordination (between regulator and reimbursement bodies), and the inability to generalize findings from evidence synthesis to be key challenges in the HTA of medical devices. The lack of evidence for differentiation in scientific methods for HTA of devices raises the question of whether HTA needs to develop new methods for medical devices but rather adapt existing methodological approaches. In contrast, organizational and/or procedural adaptation of existing HTA agency frameworks to accommodate medical devices appear relatively commonplace.

Designing a solution to enable agency-academic scientific collaboration for disasters

USGS Publications Warehouse

Mease, Lindley A.; Gibbs-Plessl, Theodora; Erickson, Ashley; Ludwig, Kristin A.; Reddy, Christopher M.; Lubchenco, Jane

2017-01-01

As large-scale environmental disasters become increasingly frequent and more severe globally, people and organizations that prepare for and respond to these crises need efficient and effective ways to integrate sound science into their decision making. Experience has shown that integrating nongovernmental scientific expertise into disaster decision making can improve the quality of the response, and is most effective if the integration occurs before, during, and after a crisis, not just during a crisis. However, collaboration between academic, government, and industry scientists, decision makers, and responders is frequently difficult because of cultural differences, misaligned incentives, time pressures, and legal constraints. Our study addressed this challenge by using the Deep Change Method, a design methodology developed by Stanford ChangeLabs, which combines human-centered design, systems analysis, and behavioral psychology. We investigated underlying needs and motivations of government agency staff and academic scientists, mapped the root causes underlying the relationship failures between these two communities based on their experiences, and identified leverage points for shifting deeply rooted perceptions that impede collaboration. We found that building trust and creating mutual value between multiple stakeholders before crises occur is likely to increase the effectiveness of problem solving. We propose a solution, the Science Action Network, which is designed to address barriers to scientific collaboration by providing new mechanisms to build and improve trust and communication between government administrators and scientists, industry representatives, and academic scientists. The Science Action Network has the potential to ensure cross-disaster preparedness and science-based decision making through novel partnerships and scientific coordination.

40 CFR 166.25 - Agency review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... benefits to be derived from the proposed use; and (4) The potential risks to human health, endangered or... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public...

40 CFR 166.25 - Agency review.

Code of Federal Regulations, 2011 CFR

2011-07-01

... benefits to be derived from the proposed use; and (4) The potential risks to human health, endangered or... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public...

40 CFR 166.25 - Agency review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... benefits to be derived from the proposed use; and (4) The potential risks to human health, endangered or... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public...

40 CFR 166.25 - Agency review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... benefits to be derived from the proposed use; and (4) The potential risks to human health, endangered or... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public...

40 CFR 166.25 - Agency review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... benefits to be derived from the proposed use; and (4) The potential risks to human health, endangered or... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public...

75 FR 28255 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... Center). AHRQ is the lead agency charged with supporting research designed to improve the quality of... are designed to help these decision makers use research evidence to maximize the benefits of health... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Agency...

75 FR 52347 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

... Center). AHRQ is the lead agency charged with supporting research designed to improve the quality of... are designed to help these decision makers use research evidence to maximize the benefits of health... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Agency...

75 FR 44796 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... Center). AHRQ is the lead agency charged with supporting research designed to improve the quality of... are designed to help these decision makers use research evidence to maximize the benefits of health... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Agency...

Development of an integrated CAD-FEA system for patient-specific design of spinal cages.

PubMed

Zhang, Mingzheng; Pu, Fang; Xu, Liqiang; Zhang, Linlin; Liang, Hang; Li, Deyu; Wang, Yu; Fan, Yubo

2017-03-01

Spinal cages are used to create a suitable mechanical environment for interbody fusion in cases of degenerative spinal instability. Due to individual variations in bone structures and pathological conditions, patient-specific cages can provide optimal biomechanical conditions for fusion, strengthening patient recovery. Finite element analysis (FEA) is a valuable tool in the biomechanical evaluation of patient-specific cage designs, but the time- and labor-intensive process of modeling limits its clinical application. In an effort to facilitate the design and analysis of patient-specific spinal cages, an integrated CAD-FEA system (CASCaDeS, comprehensive analytical spinal cage design system) was developed. This system produces a biomechanical-based patient-specific design of spinal cages and is capable of rapid implementation of finite element modeling. By comparison with commercial software, this system was validated and proven to be both accurate and efficient. CASCaDeS can be used to design patient-specific cages with a superior biomechanical performance to commercial spinal cages.

NASA software specification and evaluation system design, part 2

NASA Technical Reports Server (NTRS)

1976-01-01

A survey and analysis of the existing methods, tools and techniques employed in the development of software are presented along with recommendations for the construction of reliable software. Functional designs for software specification language, and the data base verifier are presented.

38 CFR 0.735-1 - Agency ethics officials.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Agency ethics officials... STANDARDS OF ETHICAL CONDUCT AND RELATED RESPONSIBILITIES General Provisions § 0.735-1 Agency ethics officials. (a) Designated Agency Ethics Official (DAEO). The Assistant General Counsel (023) is the...

38 CFR 0.735-1 - Agency ethics officials.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Agency ethics officials... STANDARDS OF ETHICAL CONDUCT AND RELATED RESPONSIBILITIES General Provisions § 0.735-1 Agency ethics officials. (a) Designated Agency Ethics Official (DAEO). The Assistant General Counsel (023) is the...

38 CFR 0.735-1 - Agency ethics officials.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Agency ethics officials... STANDARDS OF ETHICAL CONDUCT AND RELATED RESPONSIBILITIES General Provisions § 0.735-1 Agency ethics officials. (a) Designated Agency Ethics Official (DAEO). The Assistant General Counsel (023) is the...

38 CFR 0.735-1 - Agency ethics officials.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Agency ethics officials... VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES General Provisions § 0.735-1 Agency ethics officials. (a) Designated Agency Ethics Official (DAEO). The Assistant General Counsel (023) is...

38 CFR 0.735-1 - Agency ethics officials.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Agency ethics officials... VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES General Provisions § 0.735-1 Agency ethics officials. (a) Designated Agency Ethics Official (DAEO). The Assistant General Counsel (023) is...

Space tug thermal control. [design criteria and specifications

NASA Technical Reports Server (NTRS)

1974-01-01

It was determined that space tug will require the capability to perform its mission within a broad range of thermal environments with currently planned mission durations of up to seven days, so an investigation was conducted to define a thermal design for the forward and intertank compartments and fuel cell heat rejection system that satisfies tug requirements for low inclination geosynchronous deploy and retrieve missions. Passive concepts were demonstrated analytically for both the forward and intertank compartments, and a worst case external heating environment was determined for use during the study. The thermal control system specifications and designs which resulted from the research are shown.

Transforming Multidisciplinary Customer Requirements to Product Design Specifications

NASA Astrophysics Data System (ADS)

Ma, Xiao-Jie; Ding, Guo-Fu; Qin, Sheng-Feng; Li, Rong; Yan, Kai-Yin; Xiao, Shou-Ne; Yang, Guang-Wu

2017-09-01

With the increasing of complexity of complex mechatronic products, it is necessary to involve multidisciplinary design teams, thus, the traditional customer requirements modeling for a single discipline team becomes difficult to be applied in a multidisciplinary team and project since team members with various disciplinary backgrounds may have different interpretations of the customers' requirements. A new synthesized multidisciplinary customer requirements modeling method is provided for obtaining and describing the common understanding of customer requirements (CRs) and more importantly transferring them into a detailed and accurate product design specifications (PDS) to interact with different team members effectively. A case study of designing a high speed train verifies the rationality and feasibility of the proposed multidisciplinary requirement modeling method for complex mechatronic product development. This proposed research offersthe instruction to realize the customer-driven personalized customization of complex mechatronic product.

Agency, time, and causality

PubMed Central

Widlok, Thomas

2014-01-01

Cognitive Scientists interested in causal cognition increasingly search for evidence from non-Western Educational Industrial Rich Democratic people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition. PMID:25414683

Exploring alternate specifications to explain agency-level effects in placement decisions regarding aboriginal children: further analysis of the Canadian Incidence Study of Reported Child Abuse and Neglect Part B.

PubMed

Chabot, Martin; Fallon, Barbara; Tonmyr, Lil; MacLaurin, Bruce; Fluke, John; Blackstock, Cindy

2013-01-01

This paper builds upon the analyses presented in two companion papers (Fluke et al., 2010; Fallon et al., 2013) using data from the 1998 and 2003 cycles of the Canadian Incidence Study of Reported Child Abuse and Neglect (CIS-1998 and CIS-2003) to examine the influence of clinical and organizational characteristics on the decision to place a child in out-of-home care at the conclusion of a child maltreatment investigation. This paper explores various model specifications to explain the effect of an agency-level factor, proportion of Aboriginal reports, which emerged as a stable and significant factor through the two data collection cycles. It addresses the issue of data comparability between the two cycles and explores various re-specifications and descriptive analyses of reported models to evaluate their solidity with regards to the sampling schemes and the precise contribution of a multi-level specification. The decision to place a child in out-of-home care was examined using data from the CIS-2003. This child welfare dataset collected information about the results of nearly 12,000 child maltreatment investigations as well as a description of the characteristics of the workers and organization responsible for conducting those investigations. Multi-level statistical models were developed using MPlus software, which can accommodate dichotomous outcome variables and are more reflective of decision-making in child welfare. The models are thus multi-level binary logistic regressions. Final models revealed that two agency-level variables, 'Education degree of majority of workers' and 'Degree of centralization in the agency' clarify the nature of the effect of 'Proportion of Aboriginal reports', a stable, key second level predictor of the placement decision. The comparability of the effect of this agency-level variable across the 1998 and 2003 cycles becomes further evident through this analysis. By using a unified database including both cycles and various

Using CBPR to Assess Client Needs at a Social Service Agency.

PubMed

Amendola, Mary Grace; Nazario, Noelia; Sanchez, Veronica

2016-01-01

Community-based participatory research (CBPR) has become an important research approach for universities to partner with social service agencies by uniting them in project design, planning, implementation, and evaluation. This study involved FOCUS, an urban social service agency, and Rutgers College of Nursing (RUCON) collaboratively conducting a needs assessment to compare the health needs of its clients and their employees' perception of their clients health needs, utilizing CBPR. Qualitative data was collected using the focus group method, field notes, photographs, and observation. The employees of FOCUS facilitated focus groups, participant recruitment, and transcribed and translated data. Three themes emerged: Health Education, Cost of Health Care, and Barriers to Health Care. This study contributes to the growing body of knowledge of integrating the CBPR approach when conducting a community needs assessment with a social service agency. The CBPR approach closely reflects the identified health needs of its clients resulting in interventions that will meet their specific health needs. © 2015 Wiley Periodicals, Inc.

78 FR 33863 - Relationship Between General Design Criteria and Technical Specification Operability

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0179] Relationship Between General Design Criteria and...) 2013-05, ``NRC Position on the Relationship Between General Design Criteria and Technical Specification Operability.'' This RIS clarifies the NRC staff's position on the relationship between the general design...

Education and Broad Concepts of Agency

ERIC Educational Resources Information Center

Winch, Christopher

2014-01-01

Drawing on recent debates about the relationship between propositional and practical knowledge, this article is concerned with broad concepts of agency. Specifically, it is concerned with agency that involves the forming and putting into effect of intentions over relatively extended periods, particularly in work contexts (called, for want of a…

Visualisation and interaction design solutions to address specific demands in shared home care.

PubMed

Scandurra, Isabella; Hägglund, Maria; Koch, Sabine

2006-01-01

When care professionals from different organisations are involved in patient care, their different views on the care process may not be meaningfully integrated. To use visualisation and interaction design solutions addressing the specific demands of shared care in order to support a collaborative work process. Participatory design, comprising interdisciplinary seminar series with real users and iterative prototyping, was applied. A set of interaction and visualisation design solutions to address care professionals' requirements in shared home care is presented, introducing support for identifying origin of information, holistic presentation of information, user group specific visualisation, avoiding cognitive overload, coordination of work and planning, and quick overviews. The design solutions are implemented in an integrated virtual health record system supporting cooperation and coordination in shared home care for the elderly. The described requirements are, however, generalized to comprise all shared care work. The presented design considerations allow healthcare professionals in different organizations to share patient data on mobile devices. Visualization and interaction design facilitates specific work situations and assists in handling specific demands in shared care. The user interface is adapted to different user groups with similar yet distinct needs. Consequently different views supporting cooperative work and presenting shared information in holistic overviews are developed.

Target-cancer cell specific activatable fluorescence imaging Probes: Rational Design and in vivo Applications

PubMed Central

Kobayashi, Hisataka; Choyke, Peter L.

2010-01-01

CONSPECTUS Conventional imaging methods, such as angiography, computed tomography, magnetic resonance imaging and radionuclide imaging, rely on contrast agents (iodine, gadolinium, radioisotopes) that are “always on”. While these agents have proven clinically useful, they are not sufficiently sensitive because of the inadequate target to background ratio. A unique aspect of optical imaging is that fluorescence probes can be designed to be activatable, i.e. only “turned on” under certain conditions. These probes can be designed to emit signal only after binding a target tissue, greatly increasing sensitivity and specificity in the detection of disease. There are two basic types of activatable fluorescence probes; 1) conventional enzymatically activatable probes, which exist in the quenched state until activated by enzymatic cleavage mostly outside of the cells, and 2) newly designed target-cell specific activatable probes, which are quenched until activated in targeted cells by endolysosomal processing that results when the probe binds specific cell-surface receptors and is subsequently internalized. Herein, we present a review of the rational design and in vivo applications of target-cell specific activatable probes. Designing these probes based on their photo-chemical (e.g. activation strategy), pharmacological (e.g. biodistribution), and biological (e.g. target specificity) properties has recently allowed the rational design and synthesis of target-cell specific activatable fluorescence imaging probes, which can be conjugated to a wide variety of targeting molecules. Several different photo-chemical mechanisms have been utilized, each of which offers a unique capability for probe design. These include: self-quenching, homo- and hetero-fluorescence resonance energy transfer (FRET), H-dimer formation and photon-induced electron transfer (PeT). In addition, the repertoire is further expanded by the option for reversibility or irreversibility of the signal

Salt bridges: geometrically specific, designable interactions.

PubMed

Donald, Jason E; Kulp, Daniel W; DeGrado, William F

2011-03-01

Salt bridges occur frequently in proteins, providing conformational specificity and contributing to molecular recognition and catalysis. We present a comprehensive analysis of these interactions in protein structures by surveying a large database of protein structures. Salt bridges between Asp or Glu and His, Arg, or Lys display extremely well-defined geometric preferences. Several previously observed preferences are confirmed, and others that were previously unrecognized are discovered. Salt bridges are explored for their preferences for different separations in sequence and in space, geometric preferences within proteins and at protein-protein interfaces, co-operativity in networked salt bridges, inclusion within metal-binding sites, preference for acidic electrons, apparent conformational side chain entropy reduction on formation, and degree of burial. Salt bridges occur far more frequently between residues at close than distant sequence separations, but, at close distances, there remain strong preferences for salt bridges at specific separations. Specific types of complex salt bridges, involving three or more members, are also discovered. As we observe a strong relationship between the propensity to form a salt bridge and the placement of salt-bridging residues in protein sequences, we discuss the role that salt bridges might play in kinetically influencing protein folding and thermodynamically stabilizing the native conformation. We also develop a quantitative method to select appropriate crystal structure resolution and B-factor cutoffs. Detailed knowledge of these geometric and sequence dependences should aid de novo design and prediction algorithms. Copyright © 2010 Wiley-Liss, Inc.

5 CFR 2638.202 - Responsibilities of agency head.

Code of Federal Regulations, 2011 CFR

2011-01-01

... and shall exercise personal leadership in establishing, maintaining, and carrying out the agency's... program in a positive and effective manner. (b) Selection of a designated agency ethics official. The head...

From ergonomics to design specifications: contributions to the design of a processing machine in a tire company.

PubMed

Moraes, A S P; Arezes, P M; Vasconcelos, R

2012-01-01

The development of ergonomics' recommendations, guidelines and standards are attempts to promote the integration of ergonomics into industrial contexts. Such developments result from several sources and professionals and represent the effort that has been done to develop healthier and safer work environments. However, the availability of large amount of data and documents regarding ergonomics does not guarantee their applicability. The main goal of this paper is to use a specific case to demonstrate how ergonomics criteria were developed in order to contribute to the design of workplaces. Based on the obtained results from research undertaken in a tire company, it was observed that the ergonomics criteria should be presented as design specifications in order to be used by engineers and designers. In conclusion, it is observed that the multiple constraint environment impeded the appliance of the ergonomics criteria. It was also observed that the knowledge on technical design and the acquaintance with ergonomic standards, the level of integration in the design team, and the ability to communicate with workers and other technical staff have paramount importance in integrating ergonomics criteria into the design process.

Design, Specification, and Synthesis of Aircraft Electric Power Systems Control Logic

NASA Astrophysics Data System (ADS)

Xu, Huan

Cyber-physical systems integrate computation, networking, and physical processes. Substantial research challenges exist in the design and verification of such large-scale, distributed sensing, actuation, and control systems. Rapidly improving technology and recent advances in control theory, networked systems, and computer science give us the opportunity to drastically improve our approach to integrated flow of information and cooperative behavior. Current systems rely on text-based specifications and manual design. Using new technology advances, we can create easier, more efficient, and cheaper ways of developing these control systems. This thesis will focus on design considerations for system topologies, ways to formally and automatically specify requirements, and methods to synthesize reactive control protocols, all within the context of an aircraft electric power system as a representative application area. This thesis consists of three complementary parts: synthesis, specification, and design. The first section focuses on the synthesis of central and distributed reactive controllers for an aircraft elec- tric power system. This approach incorporates methodologies from computer science and control. The resulting controllers are correct by construction with respect to system requirements, which are formulated using the specification language of linear temporal logic (LTL). The second section addresses how to formally specify requirements and introduces a domain-specific language for electric power systems. A software tool automatically converts high-level requirements into LTL and synthesizes a controller. The final sections focus on design space exploration. A design methodology is proposed that uses mixed-integer linear programming to obtain candidate topologies, which are then used to synthesize controllers. The discrete-time control logic is then verified in real-time by two methods: hardware and simulation. Finally, the problem of partial observability and

7 CFR 3560.352 - Agency monitoring scope, purpose, and borrower responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... monitoring activities. The Agency will review reports, records, and other materials related to the housing...) Purpose of Agency monitoring activities. Agency monitoring activities are designed to assess borrower and... responsible for cooperating fully and promptly with Agency monitoring activities. Agency monitoring activities...

7 CFR 3560.352 - Agency monitoring scope, purpose, and borrower responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... monitoring activities. The Agency will review reports, records, and other materials related to the housing...) Purpose of Agency monitoring activities. Agency monitoring activities are designed to assess borrower and... responsible for cooperating fully and promptly with Agency monitoring activities. Agency monitoring activities...

7 CFR 3560.352 - Agency monitoring scope, purpose, and borrower responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... monitoring activities. The Agency will review reports, records, and other materials related to the housing...) Purpose of Agency monitoring activities. Agency monitoring activities are designed to assess borrower and... responsible for cooperating fully and promptly with Agency monitoring activities. Agency monitoring activities...

7 CFR 3560.352 - Agency monitoring scope, purpose, and borrower responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... monitoring activities. The Agency will review reports, records, and other materials related to the housing...) Purpose of Agency monitoring activities. Agency monitoring activities are designed to assess borrower and... responsible for cooperating fully and promptly with Agency monitoring activities. Agency monitoring activities...

7 CFR 3560.352 - Agency monitoring scope, purpose, and borrower responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... monitoring activities. The Agency will review reports, records, and other materials related to the housing...) Purpose of Agency monitoring activities. Agency monitoring activities are designed to assess borrower and... responsible for cooperating fully and promptly with Agency monitoring activities. Agency monitoring activities...

Development of Secondary Route Bridge Design Plan Guides

DOT National Transportation Integrated Search

2018-03-03

The objective of this study is to develop a set of bridge plan guides for low-volume traffic roads. The purpose of the plans is to facilitate construction of new structures suitable for local agencies. The designs are to specifically address common l...

77 FR 66219 - Clearing Agency Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-02

... operation of a registered clearing agency that identify minimum standards designed to enhance the regulatory...'', Securities Exchange Act Release No. 34-66868 (Apr. 27, 2012). Title VII was designed to provide greater... encourage the safe design and operation of entities that provide clearance and settlement services. The FMI...

Multinational Advertising Agencies in Latin America.

ERIC Educational Resources Information Center

Fejes, Fred

An overview of the international expansion of advertising agencies based in the United States is presented in the first part of this paper. The various types of strategies used by the agencies in their expansion efforts are discussed along with some of the problems they have faced. The second part of the paper focuses specifically on the expansion…

48 CFR 2052.227-70 - Drawings, designs, specifications, and other data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Drawings, designs, specifications, and other data. 2052.227-70 Section 2052.227-70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.227-70 Drawings, designs...

48 CFR 2052.227-70 - Drawings, designs, specifications, and other data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Drawings, designs, specifications, and other data. 2052.227-70 Section 2052.227-70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.227-70 Drawings, designs...

48 CFR 2052.227-70 - Drawings, designs, specifications, and other data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Drawings, designs, specifications, and other data. 2052.227-70 Section 2052.227-70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.227-70 Drawings, designs,...

Learning Creativity in the Client-Agency Relationship

ERIC Educational Resources Information Center

Suh, Taewon; Jung, Jae C.; Smith, Bruce L.

2012-01-01

Purpose: This study aims to investigate creativity-related determinants of learning in the context of business-to-business services and client-agency relationships. Design/methodology/approach: The research model includes client encouragement, agency creativity, campaign creativity, and perceived performance. The study involved conducting a…

Space shuttle configuration accounting functional design specification

NASA Technical Reports Server (NTRS)

1974-01-01

An analysis is presented of the requirements for an on-line automated system which must be capable of tracking the status of requirements and engineering changes and of providing accurate and timely records. The functional design specification provides the definition, description, and character length of the required data elements and the interrelationship of data elements to adequately track, display, and report the status of active configuration changes. As changes to the space shuttle program levels II and III configuration are proposed, evaluated, and dispositioned, it is the function of the configuration management office to maintain records regarding changes to the baseline and to track and report the status of those changes. The configuration accounting system will consist of a combination of computers, computer terminals, software, and procedures, all of which are designed to store, retrieve, display, and process information required to track proposed and proved engineering changes to maintain baseline documentation of the space shuttle program levels II and III.

Grounding principles for inferring agency: Two cultural perspectives.

PubMed

Ojalehto, Bethany L; Medin, Douglas L; García, Salino G

2017-06-01

The present research investigates cultural variation in grounding principles for inferring agency in order to address an important theoretical debate: does cultural diversity in agency concepts reflect an animistic overextension of (universal) folkpsychology, as many have argued, or an alternative theory of folkcommunication based on relational principles? In two experiments, mind perception measures were adapted to assess beliefs concerning the agency of non-animal kinds (plants, abiotic kinds, complex artifacts) among Indigenous Ngöbe adults in Panama and US college students. Agency attributions varied systematically, with Ngöbe ascribing greater agency to non-animal natural kinds and US college participants ascribing greater agency to complex artifacts. Analysis of explanations revealed divergent interpretations of agency as a prototypically human capacity requiring consciousness (US), versus a relational capacity expressed in directed interactions (Ngöbe). Converging measures further illuminated the inferential principles underlying these agency attributions. (1) An experimental relational framing of agency probes facilitated Ngöbe but not US agency attributions. (2) Further analysis showed that three key dimensions of agency attribution (experience, cognition, animacy) are organized differently across cultures. (3) A Bayesian approach to cultural consensus modeling confirmed the presence of two distinct consensus models rather than variations on a single (universal) model. Together, these results indicate that conceptual frameworks for agency differ across US college and Ngöbe communities. We conclude that Ngöbe concepts of agency derive from a distinct theory of folkcommunication based on an ecocentric prototype rather than overextensions of an anthropocentric folkpsychology. These observations suggest that folkpsychology and mind perception represent culture specific frameworks for agency, with significant implications for domain-specificity theory and

Engaging Gatekeepers, Optimizing Decision Making, and Mitigating Bias: Design Specifications for Systemic Diversity Interventions.

PubMed

Vinkenburg, Claartje J

2017-06-01

In this contribution to the Journal of Applied Behavioral Science Special Issue on Understanding Diversity Dynamics in Systems: Social Equality as an Organization Change Issue, I develop and describe design specifications for systemic diversity interventions in upward mobility career systems, aimed at optimizing decision making through mitigating bias by engaging gatekeepers. These interventions address the paradox of meritocracy that underlies the surprising lack of diversity at the top of the career pyramid in these systems. I ground the design specifications in the limited empirical evidence on "what works" in systemic interventions. Specifically, I describe examples from interventions in academic settings, including a bias literacy program, participatory modeling, and participant observation. The design specifications, paired with inspirational examples of successful interventions, should assist diversity officers and consultants in designing and implementing interventions to promote the advancement to and representation of nondominant group members at the top of the organizational hierarchy.

High specific energy, high capacity nickel-hydrogen cell design

NASA Technical Reports Server (NTRS)

Wheeler, James R.

1993-01-01

A 3.5 inch rabbit-ear-terminal nickel-hydrogen cell has been designed and tested to deliver high capacity at a C/1.5 discharge rate. Its specific energy yield of 60.6 wh/kg is believed to be the highest yet achieved in a slurry-process nickel-hydrogen cell, and its 10 C capacity of 113.9 AH the highest capacity yet made at a discharge rate this high in the 3.5 inch diameter size. The cell also demonstrated a pulse capability of 180 amps for 20 seconds. Specific cell parameters, performance, and future test plans are described.

20 CFR 616.2 - Consultation with the State agencies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... compensation agencies. For purposes of such consultation in its formulation and any future amendment the Secretary recognizes, as agents of the State agencies, the duly designated representatives of the National... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Consultation with the State agencies. 616.2...

20 CFR 616.2 - Consultation with the State agencies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... compensation agencies. For purposes of such consultation in its formulation and any future amendment the Secretary recognizes, as agents of the State agencies, the duly designated representatives of the National... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Consultation with the State agencies. 616.2...

20 CFR 616.2 - Consultation with the State agencies.

Code of Federal Regulations, 2013 CFR

2013-04-01

... compensation agencies. For purposes of such consultation in its formulation and any future amendment the Secretary recognizes, as agents of the State agencies, the duly designated representatives of the National... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Consultation with the State agencies. 616.2...

76 FR 71119 - Agency Information Collection Activity Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

.... Abstract: 49 U.S.C. 5330 requires States to designate a State Safety Oversight (SSO) agency to oversee the... 5330, SSO agencies must develop program standards which meet FTA's minimum requirements. In the Program Standard, which must be approved by FTA, each SSO agency must require each rail transit agency in the State...

48 CFR 8.712 - Specification changes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Specification changes. 8... Are Blind or Severely Disabled 8.712 Specification changes. (a) The contracting activity shall notify the AbilityOne participating nonprofit agency and appropriate central nonprofit agency of any change...

Engaging Gatekeepers, Optimizing Decision Making, and Mitigating Bias: Design Specifications for Systemic Diversity Interventions

PubMed Central

Vinkenburg, Claartje J.

2017-01-01

In this contribution to the Journal of Applied Behavioral Science Special Issue on Understanding Diversity Dynamics in Systems: Social Equality as an Organization Change Issue, I develop and describe design specifications for systemic diversity interventions in upward mobility career systems, aimed at optimizing decision making through mitigating bias by engaging gatekeepers. These interventions address the paradox of meritocracy that underlies the surprising lack of diversity at the top of the career pyramid in these systems. I ground the design specifications in the limited empirical evidence on “what works” in systemic interventions. Specifically, I describe examples from interventions in academic settings, including a bias literacy program, participatory modeling, and participant observation. The design specifications, paired with inspirational examples of successful interventions, should assist diversity officers and consultants in designing and implementing interventions to promote the advancement to and representation of nondominant group members at the top of the organizational hierarchy. PMID:28546644

29 CFR 1450.16 - Use of consumer reporting agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Of the specific information to be disclosed to the consumer reporting agency; and (iv) Of the rights... 29 Labor 4 2010-07-01 2010-07-01 false Use of consumer reporting agencies. 1450.16 Section 1450.16... OF CLAIMS OWED THE UNITED STATES Administrative Offset-Consumer Reporting Agencies-Contracting for...

Facility design, construction, and operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

France has been disposing of low-level radioactive waste (LLW) at the Centre de Stockage de la Manche (CSM) since 1969 and now at the Centre de Stockage de l`Aube (CSA) since 1992. In France, several agencies and companies are involved in the development and implementation of LLW technology. The Commissariat a l`Energie Atomic (CEA), is responsible for research and development of new technologies. The Agence National pour la Gestion des Dechets Radioactifs is the agency responsible for the construction and operation of disposal facilities and for wastes acceptance for these facilities. Compagnie Generale des Matieres Nucleaires provides fuel services, includingmore » uranium enrichment, fuel fabrication, and fuel reprocessing, and is thus one generator of LLW. Societe pour les Techniques Nouvelles is an engineering company responsible for commercializing CEA waste management technology and for engineering and design support for the facilities. Numatec, Inc. is a US company representing these French companies and agencies in the US. In Task 1.1 of Numatec`s contract with Martin Marietta Energy Systems, Numatec provides details on the design, construction and operation of the LLW disposal facilities at CSM and CSA. Lessons learned from operation of CSM and incorporated into the design, construction and operating procedures at CSA are identified and discussed. The process used by the French for identification, selection, and evaluation of disposal technologies is provided. Specifically, the decisionmaking process resulting in the change in disposal facility design for the CSA versus the CSM is discussed. This report provides` all of the basic information in these areas and reflects actual experience to date.« less

5 CFR 2641.302 - Separate agency components.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) extends to the whole of the agency in which the former senior employee served. An eligible former senior... senior employee who served in a designated component of the parent agency is barred from communicating to... of Defense, a former career Senior Executive Service employee was employed in a position for which...

Kineto-dynamic design optimisation for vehicle-specific seat-suspension systems

NASA Astrophysics Data System (ADS)

Shangguan, Wen-Bin; Shui, Yijie; Rakheja, Subhash

2017-11-01

Designs and analyses of seat-suspension systems are invariably performed considering effective vertical spring rate and damping properties, while neglecting important contributions due to kinematics of the widely used cross-linkage mechanism. In this study, a kineto-dynamic model of a seat-suspension is formulated to obtain relations for effective vertical suspension stiffness and damping characteristics as functions of those of the air spring and the hydraulic damper, respectively. The proposed relations are verified through simulations of the multi-body dynamic model of the cross-linkage seat-suspension in the ADAMS platform. The validity of the kineto-dynamic model is also demonstrated through comparisons of its vibration transmission response with the experimental data. The model is used to identify optimal air spring coordinates to attain nearly constant natural frequency of the suspension, irrespective of the seated body mass and seated height. A methodology is further proposed to identify optimal damping requirements for vehicle-specific suspension designs to achieve minimal seat effective amplitude transmissibility (SEAT) and vibration dose value (VDV) considering vibration spectra of different classes of earthmoving vehicles. The shock and vibration isolation performance potentials of the optimal designs are evaluated under selected vehicle vibration superimposed with shock motions. Results show that the vehicle-specific optimal designs could provide substantial reductions in the SEAT and VDV values for the vehicle classes considered.

5 CFR 2638.202 - Responsibilities of agency head.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 2638.202 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics Official... ethics program. He or she shall make available to the ethics program sufficient resources (including...

5 CFR 2638.202 - Responsibilities of agency head.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Section 2638.202 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics Official... ethics program. He or she shall make available to the ethics program sufficient resources (including...

5 CFR 2638.202 - Responsibilities of agency head.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Section 2638.202 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics Official... ethics program. He or she shall make available to the ethics program sufficient resources (including...

5 CFR 2638.202 - Responsibilities of agency head.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Section 2638.202 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics Official... ethics program. He or she shall make available to the ethics program sufficient resources (including...

Software Design for Real-Time Systems on Parallel Computers: Formal Specifications.

DTIC Science & Technology

1996-04-01

This research investigated the important issues related to the analysis and design of real - time systems targeted to parallel architectures. In...particular, the software specification models for real - time systems on parallel architectures were evaluated. A survey of current formal methods for...uniprocessor real - time systems specifications was conducted to determine their extensibility in specifying real - time systems on parallel architectures. In

The Sense of Agency Scale: A Measure of Consciously Perceived Control over One's Mind, Body, and the Immediate Environment.

PubMed

Tapal, Adam; Oren, Ela; Dar, Reuven; Eitam, Baruch

2017-01-01

The sense of agency (SoA) is defined as "the registration that I am the initiator of my actions." Both "direct" and "indirect" measurement of SoA has focused on specific contextualized perceptual events, however it has also been demonstrated that "higher level" cognitions seemingly affect the SoA. We designed a measure of person's general, context-free beliefs about having core agency-the Sense of Agency Scale (SoAS). An exploratory (EFA) and confirmatory (CFA) factor analyses on samples of 236 (Study 1) and 408 (Study 2) participants yielded two correlated factors we labeled Sense of Positive Agency (SoPA) and Sense of Negative Agency (SoNA). The construct validity of SoAS is demonstrated by its low-to-moderate correlations with conceptually relevant tools and by the moderate-strong relationship between the SoNA subscale and obsessive-compulsive (OC) symptoms ( r = 0.35). We conclude that the SoAS seems to isolate people's general beliefs in their agency from their perceived success in obtaining outcomes.

Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications.

PubMed

Kobayashi, Hisataka; Choyke, Peter L

2011-02-15

Conventional imaging methods, such as angiography, computed tomography (CT), magnetic resonance imaging (MRI), and radionuclide imaging, rely on contrast agents (iodine, gadolinium, and radioisotopes, for example) that are "always on." Although these indicators have proven clinically useful, their sensitivity is lacking because of inadequate target-to-background signal ratio. A unique aspect of optical imaging is that fluorescence probes can be designed to be activatable, that is, only "turned on" under certain conditions. These probes are engineered to emit signal only after binding a target tissue; this design greatly increases sensitivity and specificity in the detection of disease. Current research focuses on two basic types of activatable fluorescence probes. The first developed were conventional enzymatically activatable probes. These fluorescent molecules exist in the quenched state until activated by enzymatic cleavage, which occurs mostly outside of the cells. However, more recently, researchers have begun designing target-cell-specific activatable probes. These fluorophores exist in the quenched state until activated within targeted cells by endolysosomal processing, which results when the probe binds specific receptors on the cell surface and is subsequently internalized. In this Account, we present a review of the rational design and in vivo applications of target-cell-specific activatable probes. In engineering these probes, researchers have asserted control over a variety of factors, including photochemistry, pharmacological profile, and biological properties. Their progress has recently allowed the rational design and synthesis of target-cell-specific activatable fluorescence imaging probes, which can be conjugated to a wide variety of targeting molecules. Several different photochemical mechanisms have been utilized, each of which offers a unique capability for probe design. These include self-quenching, homo- and hetero-fluorescence resonance

Structure based re-design of the binding specificity of anti-apoptotic Bcl-xL

PubMed Central

Chen, T. Scott; Palacios, Hector; Keating, Amy E.

2012-01-01

Many native proteins are multi-specific and interact with numerous partners, which can confound analysis of their functions. Protein design provides a potential route to generating synthetic variants of native proteins with more selective binding profiles. Re-designed proteins could be used as research tools, diagnostics or therapeutics. In this work, we used a library screening approach to re-engineer the multi-specific anti-apoptotic protein Bcl-xL to remove its interactions with many of its binding partners, making it a high affinity and selective binder of the BH3 region of pro-apoptotic protein Bad. To overcome the enormity of the potential Bcl-xL sequence space, we developed and applied a computational/experimental framework that used protein structure information to generate focused combinatorial libraries. Sequence features were identified using structure-based modeling, and an optimization algorithm based on integer programming was used to select degenerate codons that maximally covered these features. A constraint on library size was used to ensure thorough sampling. Using yeast surface display to screen a designed library of Bcl-xL variants, we successfully identified a protein with ~1,000-fold improvement in binding specificity for the BH3 region of Bad over the BH3 region of Bim. Although negative design was targeted only against the BH3 region of Bim, the best re-designed protein was globally specific against binding to 10 other peptides corresponding to native BH3 motifs. Our design framework demonstrates an efficient route to highly specific protein binders and may readily be adapted for application to other design problems. PMID:23154169

Design for Additive Bio-Manufacturing: From Patient-Specific Medical Devices to Rationally Designed Meta-Biomaterials.

PubMed

Zadpoor, Amir A

2017-07-25

Recent advances in additive manufacturing (AM) techniques in terms of accuracy, reliability, the range of processable materials, and commercial availability have made them promising candidates for production of functional parts including those used in the biomedical industry. The complexity-for-free feature offered by AM means that very complex designs become feasible to manufacture, while batch-size-indifference enables fabrication of fully patient-specific medical devices. Design for AM (DfAM) approaches aim to fully utilize those features for development of medical devices with substantially enhanced performance and biomaterials with unprecedented combinations of favorable properties that originate from complex geometrical designs at the micro-scale. This paper reviews the most important approaches in DfAM particularly those applicable to additive bio-manufacturing including image-based design pipelines, parametric and non-parametric designs, metamaterials, rational and computationally enabled design, topology optimization, and bio-inspired design. Areas with limited research have been identified and suggestions have been made for future research. The paper concludes with a brief discussion on the practical aspects of DfAM and the potential of combining AM with subtractive and formative manufacturing processes in so-called hybrid manufacturing processes.

Design for Additive Bio-Manufacturing: From Patient-Specific Medical Devices to Rationally Designed Meta-Biomaterials

PubMed Central

Zadpoor, Amir A.

2017-01-01

Recent advances in additive manufacturing (AM) techniques in terms of accuracy, reliability, the range of processable materials, and commercial availability have made them promising candidates for production of functional parts including those used in the biomedical industry. The complexity-for-free feature offered by AM means that very complex designs become feasible to manufacture, while batch-size-indifference enables fabrication of fully patient-specific medical devices. Design for AM (DfAM) approaches aim to fully utilize those features for development of medical devices with substantially enhanced performance and biomaterials with unprecedented combinations of favorable properties that originate from complex geometrical designs at the micro-scale. This paper reviews the most important approaches in DfAM particularly those applicable to additive bio-manufacturing including image-based design pipelines, parametric and non-parametric designs, metamaterials, rational and computationally enabled design, topology optimization, and bio-inspired design. Areas with limited research have been identified and suggestions have been made for future research. The paper concludes with a brief discussion on the practical aspects of DfAM and the potential of combining AM with subtractive and formative manufacturing processes in so-called hybrid manufacturing processes. PMID:28757572

Engaging Young Children in Collective Curriculum Design

ERIC Educational Resources Information Center

Goulart, Maria Ines Mafra; Roth, Wolff-Michael

2010-01-01

In this study we investigate how 5-year-old children in Brazil and their teachers collectively design science curriculum. More specifically, we develop an agency|structure dialectic as a framework to describe this collective praxis in which science curriculum may emerge as the result of children-teacher transactions rather than as a result of…

78 FR 11555 - Special Conditions: Embraer S.A., Model EMB-550 Airplane; Design Roll Maneuver for Electronic...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

...; Design Roll Maneuver for Electronic Flight Controls AGENCY: Federal Aviation Administration (FAA), DOT... design roll maneuver for electronic flight controls, specifically an electronic flight control system... control surfaces. The Model EMB-550 airplane is designed for 8 passengers, with a maximum of 12 passengers...

Musical Agency during Physical Exercise Decreases Pain.

PubMed

Fritz, Thomas H; Bowling, Daniel L; Contier, Oliver; Grant, Joshua; Schneider, Lydia; Lederer, Annette; Höer, Felicia; Busch, Eric; Villringer, Arno

2017-01-01

Objectives: When physical exercise is systematically coupled to music production, exercisers experience improvements in mood, reductions in perceived effort, and enhanced muscular efficiency. The physiology underlying these positive effects remains unknown. Here we approached the investigation of how such musical agency may stimulate the release of endogenous opioids indirectly with a pain threshold paradigm. Design: In a cross-over design we tested the opioid-hypothesis with an indirect measure, comparing the pain tolerance of 22 participants following exercise with or without musical agency. Method: Physical exercise was coupled to music by integrating weight-training machines with sensors that control music-synthesis in real time. Pain tolerance was measured as withdrawal time in a cold pressor test. Results: On average, participants tolerated cold pain for ~5 s longer following exercise sessions with musical agency. Musical agency explained 25% of the variance in cold pressor test withdrawal times after factoring out individual differences in general pain sensitivity. Conclusions: This result demonstrates a substantial pain reducing effect of musical agency in combination with physical exercise, probably due to stimulation of endogenous opioid mechanisms. This has implications for exercise endurance, both in sports and a multitude of rehabilitative therapies in which physical exercise is effective but painful.

Musical Agency during Physical Exercise Decreases Pain

PubMed Central

Fritz, Thomas H.; Bowling, Daniel L.; Contier, Oliver; Grant, Joshua; Schneider, Lydia; Lederer, Annette; Höer, Felicia; Busch, Eric; Villringer, Arno

2018-01-01

Objectives: When physical exercise is systematically coupled to music production, exercisers experience improvements in mood, reductions in perceived effort, and enhanced muscular efficiency. The physiology underlying these positive effects remains unknown. Here we approached the investigation of how such musical agency may stimulate the release of endogenous opioids indirectly with a pain threshold paradigm. Design: In a cross-over design we tested the opioid-hypothesis with an indirect measure, comparing the pain tolerance of 22 participants following exercise with or without musical agency. Method: Physical exercise was coupled to music by integrating weight-training machines with sensors that control music-synthesis in real time. Pain tolerance was measured as withdrawal time in a cold pressor test. Results: On average, participants tolerated cold pain for ~5 s longer following exercise sessions with musical agency. Musical agency explained 25% of the variance in cold pressor test withdrawal times after factoring out individual differences in general pain sensitivity. Conclusions: This result demonstrates a substantial pain reducing effect of musical agency in combination with physical exercise, probably due to stimulation of endogenous opioid mechanisms. This has implications for exercise endurance, both in sports and a multitude of rehabilitative therapies in which physical exercise is effective but painful. PMID:29387030

The Johnson Space Center Management Information Systems (JSCMIS). 1: Requirements Definition and Design Specifications for Versions 2.1 and 2.1.1. 2: Documented Test Scenario Environments. 3: Security Design and Specifications

NASA Technical Reports Server (NTRS)

1986-01-01

The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at NASA Johnson which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. This issue gives requirements definition and design specifications for versions 2.1 and 2.1.1, along with documented test scenario environments, and security object design and specifications.

Digital orthoimagery base specification V1.0

USGS Publications Warehouse

Rufe, Philip P.

2014-01-01

The resolution requirement for orthoimagery in support of the The National Map of the U.S. Geological Survey (USGS) is 1 meter. However, as the Office of Management and Budget A-16 designated Federal agency responsible for base orthoimagery, the USGS National Geospatial Program (NGP) has developed this base specification to include higher resolution orthoimagery. Many Federal, State, and local programs use high-resolution orthoimagery for various purposes including critical infrastructure management, vector data updates, land-use analysis, natural resource inventory, and extraction of data. The complex nature of large-area orthoimagery datasets, combined with the broad interest in orthoimagery, which is of consistent quality and spatial accuracy, requires high-resolution orthoimagery to meet or exceed the format and content outlined in this specification. The USGS intends to use this specification primarily to create consistency across all NGP funded and managed orthoimagery collections, in particular, collections in support of the National Digital Orthoimagery Program (NDOP). In the absence of other comprehensive specifications or standards, the USGS intends that this specification will, to the highest degree practical, be adopted by other USGS programs and mission areas, and by other Federal agencies. This base specification, defining minimum parameters for orthoimagery data collection. Local conditions in any given project area, specialized applications for the data, or the preferences of cooperators, may mandate more stringent requirements. The USGS fully supports the acquisition of more detailed, accurate, or value-added data that exceed the base specification outlined herein. A partial list of common “buy-up” options is provided in appendix 1 for those areas and projects that require more stringent or expanded specifications.

42 CFR 495.350 - State Medicaid agency attestations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false State Medicaid agency attestations. 495.350 Section 495.350 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... INCENTIVE PROGRAM Requirements Specific to the Medicaid Program § 495.350 State Medicaid agency attestations...

High specific energy, high capacity nickel-hydrogen cell design

NASA Technical Reports Server (NTRS)

Wheeler, James R.

1993-01-01

A 3.5 inch rabbit-ear-terminal nickel-hydrogen cell was designed and tested to deliver high capacity at steady discharge rates up to and including a C rate. Its specific energy yield of 60.6 wh/kg is believed to be the highest yet achieved in a slurry-process nickel-hydrogen cell, and its 10 C capacity of 113.9 AH the highest capacity yet of any type in a 3.5 inch diameter size. The cell also demonstrated a pulse capability of 180 amps for 20 seconds. Specific cell parameters and performance are described. Also covered is an episode of capacity fading due to electrode swelling and its successful recovery by means of additional activation procedures.

Solar Photovoltaic Financing: Deployment by Federal Government Agencies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cory, K.; Coggeshall, C.; Coughlin, J.

2009-07-01

The goal of this report is to examine how federal agencies can finance on-site PV projects. It explains state-level cash incentives available, the importance of solar renewable energy certificate revenues (in certain markets), existing financing structures, as well as innovative financing structures being used by federal agencies to deploy on-site PV. Specific examples from the DOD, DOE, and other federal agencies are highlighted to explain federal project financing in detail.

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

PubMed Central

2012-01-01

Background Choosing appropriate primers is probably the single most important factor affecting the polymerase chain reaction (PCR). Specific amplification of the intended target requires that primers do not have matches to other targets in certain orientations and within certain distances that allow undesired amplification. The process of designing specific primers typically involves two stages. First, the primers flanking regions of interest are generated either manually or using software tools; then they are searched against an appropriate nucleotide sequence database using tools such as BLAST to examine the potential targets. However, the latter is not an easy process as one needs to examine many details between primers and targets, such as the number and the positions of matched bases, the primer orientations and distance between forward and reverse primers. The complexity of such analysis usually makes this a time-consuming and very difficult task for users, especially when the primers have a large number of hits. Furthermore, although the BLAST program has been widely used for primer target detection, it is in fact not an ideal tool for this purpose as BLAST is a local alignment algorithm and does not necessarily return complete match information over the entire primer range. Results We present a new software tool called Primer-BLAST to alleviate the difficulty in designing target-specific primers. This tool combines BLAST with a global alignment algorithm to ensure a full primer-target alignment and is sensitive enough to detect targets that have a significant number of mismatches to primers. Primer-BLAST allows users to design new target-specific primers in one step as well as to check the specificity of pre-existing primers. Primer-BLAST also supports placing primers based on exon/intron locations and excluding single nucleotide polymorphism (SNP) sites in primers. Conclusions We describe a robust and fully implemented general purpose primer design tool

5 CFR 1320.7 - Agency head and Senior Official responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Agency head and Senior Official... CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.7 Agency head and Senior Official responsibilities. (a) Except as provided in paragraph (b) of this section, each agency head shall designate a Senior Official...

Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids.

PubMed

Lau, King Hang Aaron; Sileika, Tadas S; Park, Sung Hyun; Sousa, Ana Maria Leal; Burch, Patrick; Szleifer, Igal; Messersmith, Phillip B

2015-01-07

Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevent non-specific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) "peptoids" are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with a different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs were found to give rise to distinct but subtle differences in properties. The results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.

EFFECTIVE COLLECTION AGENCY USE: THE IMPORTANCE OF INTERNAL POLICIES.

PubMed

Scroggins, Robert C

2014-11-25

Increasing patient accountability for the cost of healthcare means physician practices likely will need to improve their internal collection processes and consider contracting with an outside collection agency. But choosing a good collection agency is the second priority. The first is establishing well-thought-out and specific internal procedures for collecting as much as possible before turning to an outside collection agency.

Hiring and Screening Practices of Agencies Supplying Paid Caregivers to Older Adults

PubMed Central

Lindquist, Lee A.; Cameron, Kenzie A.; Messerges-Bernstein, Joanne; Friesema, Elisha; Zickuhr, Lisa; Baker, David W.; Wolf, Michael

2012-01-01

Objectives To assess what screening practices agencies use in hiring caregivers and how caregiver competency is measured prior to assigning older adult responsibilities. Design One-to-one phone interviewers where interviewers posed as prospective clients seeking a caregiver for an older adult relative. Setting Cross-sectional cohort of agencies supplying paid caregivers to older adults in Illinois, California, Florida, Colorado, Arizona, Wisconsin, and Indiana. Participants 462 home care agencies were contacted, of which 84 were no longer in service, 165 offered only nursing care, and 33 were excluded. 180 agencies completed interviews. Measurements Agencies were surveyed about their hiring methods, screening measures, training practices, skill competencies assessments, and supervision. Open ended responses were qualitatively analyzed by two coders. Results To recruit caregivers, agencies primarily used print and internet (e.g. Craigslist.com) advertising (n=69, 39.2%) and word-of-mouth referrals (n=49, 27.8%). In hiring, agencies required prior “life experiences” (n=121, 68.8%) of which less (n=33, 27.2%) were specific to care giving. Screening measures included federal criminal background checks (n=96, 55.8%) and drug testing (n= 56, 31.8%). Agencies stated that the paid caregiver could perform medication reminding (n=169, 96.0%).Skill competency was assessed by caregiver self-report (n=103, 58.5%), testing (n=62, 35.2%), and client feedback (n=62, 35.2%). General caregiver training length ranged from 0–7 days. Supervision ranged from none to weekly and included home visits, phone calls, and caregivers visiting the central office. Conclusion Using an agency to hire paid caregivers may give older adults and their families a false sense of security regarding the background and skill set of the caregiver. PMID:22724430

Investigating an Open Methodology for Designing Domain-Specific Language Collections

ERIC Educational Resources Information Center

Fitzgerald, Alannah; Wu, Shaoqun; Barge, Martin

2014-01-01

With this research and design paper, we are proposing that Open Educational Resources (OERs) and Open Access (OA) publications give increasing access to high quality online educational and research content for the development of powerful domain-specific language collections that can be further enhanced linguistically with the Flexible Language…

Just-in-time Design and Additive Manufacture of Patient-specific Medical Implants

NASA Astrophysics Data System (ADS)

Shidid, Darpan; Leary, Martin; Choong, Peter; Brandt, Milan

Recent advances in medical imaging and manufacturing science have enabled the design and production of complex, patient-specific orthopaedic implants. Additive Manufacture (AM) generates three-dimensional structures layer by layer, and is not subject to the constraints associated with traditional manufacturing methods. AM provides significant opportunities for the design of novel geometries and complex lattice structures with enhanced functional performance. However, the design and manufacture of patient-specific AM implant structures requires unique expertise in handling various optimization platforms. Furthermore, the design process for complex structures is computationally intensive. The primary aim of this research is to enable the just-in-time customisation of AM prosthesis; whereby AM implant design and manufacture be completed within the time constraints of a single surgical procedure, while minimising prosthesis mass and optimising the lattice structure to match the stiffness of the surrounding bone tissue. In this research, a design approach using raw CT scan data is applied to the AM manufacture of femoral prosthesis. Using the proposed just-in-time concept, the mass of the prosthesis was rapidly designed and manufactured while satisfying the associated structural requirements. Compressive testing of lattice structures manufactured using proposed method shows that the load carrying capacity of the resected composite bone can be recovered by up to 85% and the compressive stiffness of the AM prosthesis is statistically indistinguishable from the stiffness of the initial bone.

40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with design specifications and manufacturing and test requirements. (a) Overview. (1) Paragraphs... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Demonstration of compliance with design specifications and manufacturing and test requirements. 53.51 Section 53.51 Protection of Environment...

Are human service agencies ready for disasters? Findings from a mixed-methods needs assessment and planning project.

PubMed

Hipper, Thomas J; Orr, Ashley; Chernak, Esther

2015-01-01

A mixed-methods design was used to assess the current capacity of human service agencies to provide services in a major disaster, identify challenges and successful strategies for providing those services, and formulate specific recommendations for government planners and the nonprofit sector to promote the integration of human service agencies into emergency preparedness and response. A web-based survey was completed by 188 unique human service agencies, 31 semistructured interviews were conducted with human service agency and government leaders from southeastern Pennsylvania and the mid-Atlantic region, and a collaborative planning meeting was held to review the findings and develop systems-based recommendations. Survey results indicated that human service agencies serve the most vulnerable communities during disasters and would welcome integration into preparedness and response plans, but they currently face challenges that include a lack of real-time communication and opportunities for collaborative planning with government partners. Interview findings were grouped according to 5 themes that emerged: capacity, coordination, communication, training, and leadership. This study identified recommendations to assist human service agencies, local health departments, and emergency management agencies as they work to ensure that needed human services are available during disasters, despite the resource challenges that most agencies face.

A contribution to the design specification of single-cell multi-resonant converters

NASA Astrophysics Data System (ADS)

Franck, F.; Schroeder, D.

The state plane technique is used to develop a design-specification procedure that enables the designer to directly calculate the stresses on all elements of the different topologies for quasi-resonant converters. If parasitic elements are considered, multiresonant topologies are obtained. These topologies can be calculated for the design specification if the procedure for quasi-resonant topologies is adapted to this situation. A novel theoretical approach for describing the internal behavior of multiresonant converters and for visualizing the switching conditions and the points of maximum component stresses is proposed. The multiresonant switching technique combines two advantages: the lossless snubbing of both the transistor and the diode is achieved by only three reactive elements, and a controllable no-load operation is possible. This analysis procedure is well suited for calculating dc-dc converter with an output power up to several hundred watts.

77 FR 5255 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... Education activities. AHRQ is the lead agency charged with supporting research designed to improve the... results from comparative effectiveness research studies. The planned assessment approaches will promote... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Agency...

Experiences with the hydraulic design of the high specific speed Francis turbine

NASA Astrophysics Data System (ADS)

Obrovsky, J.; Zouhar, J.

2014-03-01

The high specific speed Francis turbine is still suitable alternative for refurbishment of older hydro power plants with lower heads and worse cavitation conditions. In the paper the design process of such kind of turbine together with the results comparison of homological model tests performed in hydraulic laboratory of ČKD Blansko Engineering is introduced. The turbine runner was designed using the optimization algorithm and considering the high specific speed hydraulic profile. It means that hydraulic profiles of the spiral case, the distributor and the draft tube were used from a Kaplan turbine. The optimization was done as the automatic cycle and was based on a simplex optimization method as well as on a genetic algorithm. The number of blades is shown as the parameter which changes the resulting specific speed of the turbine between ns=425 to 455 together with the cavitation characteristics. Minimizing of cavitation on the blade surface as well as on the inlet edge of the runner blade was taken into account during the design process. The results of CFD analyses as well as the model tests are mentioned in the paper.

Commercial agencies and surrogate motherhood: a transaction cost approach.

PubMed

Galbraith, Mhairi; McLachlan, Hugh V; Swales, J Kim

2005-03-01

In this paper we investigate the legal arrangements involved in UK surrogate motherhood from a transaction-cost perspective. We outline the specific forms the transaction costs take and critically comment on the way in which the UK institutional and organisational arrangements at present adversely influence transaction costs. We then focus specifically on the potential role of surrogacy agencies and look at UK and US evidence on commercial and voluntary agencies. Policy implications follow.

Agency for toxic substances and disease registry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The congressional mandates under which the Agency for Toxic Substances and Disease Registry (ATSDR) operates are generally broad in scope, but very specific in intent. They concern the health effects of human exposure to hazardous substances in the environment. This report recounts the accomplishments in meeting specific mandates and indicates plans and directions for work to meet others. The report is organized by program area and covers the federal fiscal year 1987 (October 1, 1986 through September 30, 1987). Two items of importance were performed in FY 1987 by senior management at ATSDR that are not directly reportable by individualmore » program area: first, the priorities of the agency's programs were reordered, and second, the formation of an ATSDR Board of Scientific Counselors was initiated. The reordering of priorities reflects the agency's have in met certain mandates (such as completion of the first 25 toxicological profiles) and takes cognizance of other congressionally mandated deadlines (such as performing health assessments for all National Priorities List Superfund sites). The agency is establishing a Board of Scientific Counselors to provide advice and guidance on ATSDR's programs to ensure scientific quality, timeliness, utility, and dissemination of results. Specifically, the board will advise on the adequacy of science in ATSDR-supported research, emerging problems that require scientific investigation, accuracy and currency of science in ATSDR reports, and program areas to be emphasized and/or deemphasized. The Agency for Toxic Substances and Disease Registry continued , in FY 1987, to meet its mission of preventing of mitigating adverse human health effects and diminished quality of life resulting from exposure to hazardous substances in the environment. 156 refs.« less

Identification and evaluation of the cost-effectiveness of highway design features to reduce nonrecurrent congestion. [supporting datasets

DOT National Transportation Integrated Search

2014-01-01

This project focused specifically on design treatments that can be used to improve travel time reliability. The objectives of this research were to (1) identify the full range of possible roadway design features used by transportation agencies to imp...

36 CFR 1234.32 - What does an agency have to do to certify a fire-safety detection and suppression system?

Code of Federal Regulations, 2011 CFR

2011-07-01

... building code that have been incorporated to limit destruction of records. The report should make specific... Association, and any testing or modeling or other sources used in the design. (b) NARA action. (1) NARA will... determination. Before any consultation, NARA may ask the agency for additional clarifying information. NARA will...

36 CFR 1234.32 - What does an agency have to do to certify a fire-safety detection and suppression system?

Code of Federal Regulations, 2014 CFR

2014-07-01

... building code that have been incorporated to limit destruction of records. The report should make specific... Association, and any testing or modeling or other sources used in the design. (b) NARA action. (1) NARA will... determination. Before any consultation, NARA may ask the agency for additional clarifying information. NARA will...

36 CFR 1234.32 - What does an agency have to do to certify a fire-safety detection and suppression system?

Code of Federal Regulations, 2012 CFR

2012-07-01

... building code that have been incorporated to limit destruction of records. The report should make specific... Association, and any testing or modeling or other sources used in the design. (b) NARA action. (1) NARA will... determination. Before any consultation, NARA may ask the agency for additional clarifying information. NARA will...

A tool for design of primers for microRNA-specific quantitative RT-qPCR.

PubMed

Busk, Peter K

2014-01-28

MicroRNAs are small but biologically important RNA molecules. Although different methods can be used for quantification of microRNAs, quantitative PCR is regarded as the reference that is used to validate other methods. Several commercial qPCR assays are available but they often come at a high price and the sequences of the primers are not disclosed. An alternative to commercial assays is to manually design primers but this work is tedious and, hence, not practical for the design of primers for a larger number of targets. I have developed the software miRprimer for automatic design of primers for the method miR-specific RT-qPCR, which is one of the best performing microRNA qPCR methods available. The algorithm is based on an implementation of the previously published rules for manual design of miR-specific primers with the additional feature of evaluating the propensity of formation of secondary structures and primer dimers. Testing of the primers showed that 76 out of 79 primers (96%) worked for quantification of microRNAs by miR-specific RT-qPCR of mammalian RNA samples. This success rate corresponds to the success rate of manual primer design. Furthermore, primers designed by this method have been distributed to several labs and used successfully in published studies. The software miRprimer is an automatic and easy method for design of functional primers for miR-specific RT-qPCR. The application is available as stand-alone software that will work on the MS Windows platform and in a developer version written in the Ruby programming language.

Advanced Wet Tantalum Capacitors: Design, Specifications and Performance

NASA Technical Reports Server (NTRS)

Teverovsky, Alexander

2016-01-01

Insertion of new types of commercial, high volumetric efficiency wet tantalum capacitors in space systems requires reassessment of the existing quality assurance approaches that have been developed for capacitors manufactured to MIL-PRF-39006 requirements. The specifics of wet electrolytic capacitors is that leakage currents flowing through electrolyte can cause gas generation resulting in building up of internal gas pressure and rupture of the case. The risk associated with excessive leakage currents and increased pressure is greater for high value advanced wet tantalum capacitors, but it has not been properly evaluated yet. This presentation gives a review of specifics of the design, performance, and potential reliability risks associated with advanced wet tantalum capacitors. Problems related to setting adequate requirements for DPA, leakage currents, hermeticity, stability at low and high temperatures, ripple currents for parts operating in vacuum, and random vibration testing are discussed. Recommendations for screening and qualification to reduce risks of failures have been suggested.

Advanced Wet Tantalum Capacitors: Design, Specifications and Performance

NASA Technical Reports Server (NTRS)

Teverovsky, Alexander

2017-01-01

Insertion of new types of commercial, high volumetric efficiency wet tantalum capacitors in space systems requires reassessment of the existing quality assurance approaches that have been developed for capacitors manufactured to MIL-PRF-39006 requirements. The specifics of wet electrolytic capacitors is that leakage currents flowing through electrolyte can cause gas generation resulting in building up of internal gas pressure and rupture of the case. The risk associated with excessive leakage currents and increased pressure is greater for high value advanced wet tantalum capacitors, but it has not been properly evaluated yet. This presentation gives a review of specifics of the design, performance, and potential reliability risks associated with advanced wet tantalum capacitors. Problems related to setting adequate requirements for DPA, leakage currents, hermeticity, stability at low and high temperatures, ripple currents for parts operating in vacuum, and random vibration testing are discussed. Recommendations for screening and qualification to reduce risks of failures have been suggested.

Home Health Agency Work Environments and Hospitalizations

PubMed Central

Flynn, Linda; Lake, Eileen T.; Aiken, Linda H.

2014-01-01

Background: An important goal of home health care is to assist patients to remain in community living arrangements. Yet home care often fails to prevent hospitalizations and to facilitate discharges to community living, thus putting patients at risk of additional health challenges and increasing care costs. Objectives: To determine the relationship between home health agency work environments and agency-level rates of acute hospitalization and discharges to community living. Methods and Design: Analysis of linked Center for Medicare and Medicaid Services Home Health Compare data and nurse survey data from 118 home health agencies. Robust regression models were used to estimate the effect of work environment ratings on between-agency variation in rates of acute hospitalization and community discharge. Results: Home health agencies with good work environments had lower rates of acute hospitalizations and higher rates of patient discharges to community living arrangements compared with home health agencies with poor work environments. Conclusion: Improved work environments in home health agencies hold promise for optimizing patient outcomes and reducing use of expensive hospital and institutional care. PMID:25215647

Application-specific coarse-grained reconfigurable array: architecture and design methodology

NASA Astrophysics Data System (ADS)

Zhou, Li; Liu, Dongpei; Zhang, Jianfeng; Liu, Hengzhu

2015-06-01

Coarse-grained reconfigurable arrays (CGRAs) have shown potential for application in embedded systems in recent years. Numerous reconfigurable processing elements (PEs) in CGRAs provide flexibility while maintaining high performance by exploring different levels of parallelism. However, a difference remains between the CGRA and the application-specific integrated circuit (ASIC). Some application domains, such as software-defined radios (SDRs), require flexibility with performance demand increases. More effective CGRA architectures are expected to be developed. Customisation of a CGRA according to its application can improve performance and efficiency. This study proposes an application-specific CGRA architecture template composed of generic PEs (GPEs) and special PEs (SPEs). The hardware of the SPE can be customised to accelerate specific computational patterns. An automatic design methodology that includes pattern identification and application-specific function unit generation is also presented. A mapping algorithm based on ant colony optimisation is provided. Experimental results on the SDR target domain show that compared with other ordinary and application-specific reconfigurable architectures, the CGRA generated by the proposed method performs more efficiently for given applications.

OfftargetFinder: a web tool for species-specific RNAi design.

PubMed

Good, R T; Varghese, T; Golz, J F; Russell, D A; Papanicolaou, A; Edwards, O; Robin, C

2016-04-15

RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatic web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process. http://rnai.specifly.org crobin@unimelb.edu.au. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Evolution of design considerations in complex craniofacial reconstruction using patient-specific implants.

PubMed

Peel, Sean; Bhatia, Satyajeet; Eggbeer, Dominic; Morris, Daniel S; Hayhurst, Caroline

2017-06-01

Previously published evidence has established major clinical benefits from using computer-aided design, computer-aided manufacturing, and additive manufacturing to produce patient-specific devices. These include cutting guides, drilling guides, positioning guides, and implants. However, custom devices produced using these methods are still not in routine use, particularly by the UK National Health Service. Oft-cited reasons for this slow uptake include the following: a higher up-front cost than conventionally fabricated devices, material-choice uncertainty, and a lack of long-term follow-up due to their relatively recent introduction. This article identifies a further gap in current knowledge - that of design rules, or key specification considerations for complex computer-aided design/computer-aided manufacturing/additive manufacturing devices. This research begins to address the gap by combining a detailed review of the literature with first-hand experience of interdisciplinary collaboration on five craniofacial patient case studies. In each patient case, bony lesions in the orbito-temporal region were segmented, excised, and reconstructed in the virtual environment. Three cases translated these digital plans into theatre via polymer surgical guides. Four cases utilised additive manufacturing to fabricate titanium implants. One implant was machined from polyether ether ketone. From the literature, articles with relevant abstracts were analysed to extract design considerations. In all, 19 frequently recurring design considerations were extracted from previous publications. Nine new design considerations were extracted from the case studies - on the basis of subjective clinical evaluation. These were synthesised to produce a design considerations framework to assist clinicians with prescribing and design engineers with modelling. Promising avenues for further research are proposed.

Design optimization of a high specific speed Francis turbine runner

NASA Astrophysics Data System (ADS)

Enomoto, Y.; Kurosawa, S.; Kawajiri, H.

2012-11-01

Francis turbine is used in many hydroelectric power stations. This paper presents the development of hydraulic performance in a high specific speed Francis turbine runner. In order to achieve the improvements of turbine efficiency throughout a wide operating range, a new runner design method which combines the latest Computational Fluid Dynamics (CFD) and a multi objective optimization method with an existing design system was applied in this study. The validity of the new design system was evaluated by model performance tests. As the results, it was confirmed that the optimized runner presented higher efficiency compared with an originally designed runner. Besides optimization of runner, instability vibration which occurred at high part load operating condition was investigated by model test and gas-liquid two-phase flow analysis. As the results, it was confirmed that the instability vibration was caused by oval cross section whirl which was caused by recirculation flow near runner cone wall.

Specific coil design for SENSE: a six-element cardiac array.

PubMed

Weiger, M; Pruessmann, K P; Leussler, C; Röschmann, P; Boesiger, P

2001-03-01

In sensitivity encoding (SENSE), the effects of inhomogeneous spatial sensitivity of surface coils are utilized for signal localization in addition to common Fourier encoding using magnetic field gradients. Unlike standard Fourier MRI, SENSE images exhibit an inhomogeneous noise distribution, which crucially depends on the geometrical sensitivity relations of the coils used. Thus, for optimum signal-to-noise-ratio (SNR) and noise homogeneity, specialized coil configurations are called for. In this article we study the implications of SENSE imaging for coil layout by means of simulations and imaging experiments in a phantom and in vivo. New, specific design principles are identified. For SENSE imaging, the elements of a coil array should be smaller than for common phased-array imaging. Furthermore, adjacent coil elements should not overlap. Based on the findings of initial investigations, a configuration of six coils was designed and built specifically for cardiac applications. The in vivo evaluation of this array showed a considerable SNR increase in SENSE images, as compared with a conventional array. Magn Reson Med 45:495-504, 2001. Copyright 2001 Wiley-Liss, Inc.

22 CFR 1509.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or agency...

20 CFR 439.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Federal agency or agency. 439.645 Section 439.645 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 439.645 Federal agency or agency. Federal agency or agency...

Toward identifying specification requirements for digital bone-anchored prosthesis design incorporating substructure fabrication: a pilot study.

PubMed

Eggbeer, Dominic; Bibb, Richard; Evans, Peter

2006-01-01

This paper is the first in a series that aims to identify the specification requirements for advanced digital technologies that may be used to design and fabricate complex, soft tissue facial prostheses. Following a review of previously reported techniques, appropriate and currently available technologies were selected and applied in a pilot study. This study uses a range of optical surface scanning, computerized tomography, computer-aided design, and rapid prototyping technologies to capture, design, and fabricate a bone-anchored auricular prosthesis, including the retentive components. The techniques are assessed in terms of their effectiveness, and the results are used to identify future research and specification requirements to direct developments. The case study identifies that while digital technologies may be used to design implant-retained facial prostheses, many limitations need to be addressed to make the techniques clinically viable. It also identifies the need to develop a more robust specification that covers areas such as resolution, accuracy, materials, and design, against which potential technologies may be assessed. There is a need to develop a specification against which potential technologies may be assessed for their suitability in soft tissue facial prosthetics. The specification will be developed using further experimental research studies.

A bibliography on formal methods for system specification, design and validation

NASA Technical Reports Server (NTRS)

Meyer, J. F.; Furchtgott, D. G.; Movaghar, A.

1982-01-01

Literature on the specification, design, verification, testing, and evaluation of avionics systems was surveyed, providing 655 citations. Journal papers, conference papers, and technical reports are included. Manual and computer-based methods were employed. Keywords used in the online search are listed.

24 CFR 3280.904 - Specific requirements for designing the transportation system.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the transportation system. 3280.904 Section 3280.904 Housing and Urban Development Regulations... SAFETY STANDARDS Transportation § 3280.904 Specific requirements for designing the transportation system. (a) General. The entire system (frame, drawbar and coupling mechanism, running gear assembly, and...

Spaceborne computer executive routine functional design specification. Volume 2: Computer executive design for space station/base

NASA Technical Reports Server (NTRS)

Kennedy, J. R.; Fitzpatrick, W. S.

1971-01-01

The computer executive functional system design concepts derived from study of the Space Station/Base are presented. Information Management System hardware configuration as directly influencing the executive design is reviewed. The hardware configuration and generic executive design requirements are considered in detail in a previous report (System Configuration and Executive Requirements Specifications for Reusable Shuttle and Space Station/Base, 9/25/70). This report defines basic system primitives and delineates processes and process control. Supervisor states are considered for describing basic multiprogramming and multiprocessing systems. A high-level computer executive including control of scheduling, allocation of resources, system interactions, and real-time supervisory functions is defined. The description is oriented to provide a baseline for a functional simulation of the computer executive system.

28 CFR 83.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Federal agency or agency. 83.645 Section 83.645 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 83.645 Federal agency or agency. Federal agency or agency...

34 CFR 84.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Federal agency or agency. 84.645 Section 84.645 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.645 Federal agency or agency. Federal agency or agency...

22 CFR 1008.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Federal agency or agency. 1008.645 Section 1008.645 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1008.645 Federal agency or agency. Federal agency or agency means any...

Designing Flavoprotein-GFP Fusion Probes for Analyte-Specific Ratiometric Fluorescence Imaging.

PubMed

Hudson, Devin A; Caplan, Jeffrey L; Thorpe, Colin

2018-02-20

The development of genetically encoded fluorescent probes for analyte-specific imaging has revolutionized our understanding of intracellular processes. Current classes of intracellular probes depend on the selection of binding domains that either undergo conformational changes on analyte binding or can be linked to thiol redox chemistry. Here we have designed novel probes by fusing a flavoenzyme, whose fluorescence is quenched on reduction by the analyte of interest, with a GFP domain to allow for rapid and specific ratiometric sensing. Two flavoproteins, Escherichia coli thioredoxin reductase and Saccharomyces cerevisiae lipoamide dehydrogenase, were successfully developed into thioredoxin and NAD + /NADH specific probes, respectively, and their performance was evaluated in vitro and in vivo. A flow cell format, which allowed dynamic measurements, was utilized in both bacterial and mammalian systems. In E. coli the first reported intracellular steady-state of the cytoplasmic thioredoxin pool was measured. In HEK293T mammalian cells, the steady-state cytosolic ratio of NAD + /NADH induced by glucose was determined. These genetically encoded fluorescent constructs represent a modular approach to intracellular probe design that should extend the range of metabolites that can be quantitated in live cells.

45 CFR 1155.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Federal agency or agency. 1155.645 Section 1155.645 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... (FINANCIAL ASSISTANCE) Definitions § 1155.645 Federal agency or agency. Federal agency or agency means any...

22 CFR 312.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Federal agency or agency. 312.645 Section 312.645 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United States...

21 CFR 1405.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Federal agency or agency. 1405.645 Section 1405.645 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1405.645 Federal agency or agency. Federal agency or agency...

Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

NASA Astrophysics Data System (ADS)

Kandavelou, Karthikeyan; Chandrasegaran, Srinivasan

Zinc finger nucleases (ZFNs) are custom-designed molecular scissors, engineered to cut at specific DNA sequences. ZFNs combine the zinc finger proteins (ZFPs) with the nonspecific cleavage domain of the FokI restriction enzyme. The DNA-binding specificity of ZFNs can be easily altered experimentally. This easy manipulation of the ZFN recognition specificity enables one to deliver a targeted double-strand break (DSB) to a genome. The targeted DSB stimulates local gene targeting by several orders of magnitude at that specific cut site via homologous recombination (HR). Thus, ZFNs have become an important experimental tool to make site-specific and permanent alterations to genomes of not only plants and mammals but also of many other organisms. Engineering of custom ZFNs involves many steps. The first step is to identify a ZFN site at or near the chosen chromosomal target within the genome to which ZFNs will bind and cut. The second step is to design and/or select various ZFP combinations that will bind to the chosen target site with high specificity and affinity. The DNA coding sequence for the designed ZFPs are then assembled by polymerase chain reaction (PCR) using oligonucleotides. The third step is to fuse the ZFP constructs to the FokI cleavage domain. The ZFNs are then expressed as proteins by using the rabbit reticulocyte in vitro transcription/translation system and the protein products assayed for their DNA cleavage specificity.

36 CFR § 1234.32 - What does an agency have to do to certify a fire-safety detection and suppression system?

Code of Federal Regulations, 2013 CFR

2013-07-01

... building code that have been incorporated to limit destruction of records. The report should make specific... Association, and any testing or modeling or other sources used in the design. (b) NARA action. (1) NARA will... determination. Before any consultation, NARA may ask the agency for additional clarifying information. NARA will...

Tolerance design of patient-specific range QA using the DMAIC framework in proton therapy.

PubMed

Rah, Jeong-Eun; Shin, Dongho; Manger, Ryan P; Kim, Tae Hyun; Oh, Do Hoon; Kim, Dae Yong; Kim, Gwe-Ya

2018-02-01

To implement the DMAIC (Define-Measure-Analyze-Improve-Control) can be used for customizing the patient-specific QA by designing site-specific range tolerances. The DMAIC framework (process flow diagram, cause and effect, Pareto chart, control chart, and capability analysis) were utilized to determine the steps that need focus for improving the patient-specific QA. The patient-specific range QA plans were selected according to seven treatment site groups, a total of 1437 cases. The process capability index, C pm was used to guide the tolerance design of patient site-specific range. For prostate field, our results suggested that the patient range measurements were capable at the current tolerance level of ±1 mm in clinical proton plans. For other site-specific ranges, we analyzed that the tolerance tends to be overdesigned to insufficient process capability calculated by the patient-specific QA data. The customized tolerances were calculated for treatment sites. Control charts were constructed to simulate the patient QA time before and after the new tolerances were implemented. It is found that the total simulation QA time was decreased on average of approximately 20% after establishing new site-specific range tolerances. We simulated the financial impact of this project. The QA failure for whole process in proton therapy would lead up to approximately 30% increase in total cost. DMAIC framework can be used to provide an effective QA by setting customized tolerances. When tolerance design is customized, the quality is reasonably balanced with time and cost demands. © 2017 American Association of Physicists in Medicine.

5 CFR 2638.203 - Duties of the designated agency ethics official.

Code of Federal Regulations, 2010 CFR

2010-01-01

... accordance with subpart G, Executive Agency Ethics Training Programs, of this part. (7) A counseling program... other audit groups is reviewed to determine whether such information discloses a need for revising...

Facilitating interdisciplinary design specification of "smart" homes for aging in place.

PubMed

Demiris, George; Skubic, Marjorie; Rantz, Marilyn J; Courtney, Karen L; Aud, Myra A; Tyrer, Harry W; He, Zhihai; Lee, Jia

2006-01-01

"Smart homes" are defined as residences equipped with sensors and other advanced technology applications that enhance residents' independence and can be used for aging in place. The objective of this study is to determine design specifications for smart residences as defined by professional groups involved both in care delivery to senior citizens and development of devices and technologies to support aging. We assessed the importance of specific devices and sensors and their advantages and disadvantages as perceived by the interdisciplinary expert team. This work lays the ground for the implementation of smart home residencies and confirms that only an interdisciplinary design approach can address all the technical, clinical and human factors related challenges associated with home-based technologies that support aging. Our findings indicate that the use of adaptive technology that can be installed in the home environment has the potential to not only support but also empower individual senior users.

A RFID specific participatory design approach to support design and implementation of real-time location systems in the operating room.

PubMed

Guédon, A C P; Wauben, L S G L; de Korne, D F; Overvelde, M; Dankelman, J; van den Dobbelsteen, J J

2015-01-01

Information technology, such as real-time location (RTL) systems using Radio Frequency IDentification (RFID) may contribute to overcome patient safety issues and high costs in healthcare. The aim of this work is to study if a RFID specific Participatory Design (PD) approach supports the design and the implementation of RTL systems in the Operating Room (OR). A RFID specific PD approach was used to design and implement two RFID based modules. The Device Module monitors the safety status of OR devices and the Patient Module tracks the patients' locations during their hospital stay. The PD principles 'multidisciplinary team', 'participation users (active involvement)' and 'early adopters' were used to include users from the RFID company, the university and the hospital. The design and implementation process consisted of two 'structured cycles' ('iterations'). The effectiveness of this approach was assessed by the acceptance in terms of level of use, continuity of the project and purchase. The Device Module included eight strategic and twelve tactical actions and the Patient Module included six strategic and twelve tactical actions. Both modules are now used on a daily basis and are purchased by the hospitals for continued use. The RFID specific PD approach was effective in guiding and supporting the design and implementation process of RFID technology in the OR. The multidisciplinary teams and their active participation provided insights in the social and the organizational context of the hospitals making it possible to better fit the technology to the hospitals' (future) needs.

36 CFR 1256.48 - Information about internal agency rules and practices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... states or assesses an agency's vulnerability to outside interference or harm. NARA withholds records that... describing specific measures that can be used to counteract such agency vulnerabilities. (b) The Archivist of...

Optimal procedures for quality assurance specifications

DOT National Transportation Integrated Search

2003-04-01

This manual is a comprehensive guide that a highway agency can use when developing new, or modifying existing, acceptance plans and quality assurance specifications. It provides necessary instruction and illustrative examples to lead the agency throu...

Origins Space Telescope: Telescope Design and Instrument Specifications

NASA Astrophysics Data System (ADS)

Meixner, Margaret; Carter, Ruth; Leisawitz, David; Dipirro, Mike; Flores, Anel; Staguhn, Johannes; Kellog, James; Roellig, Thomas L.; Melnick, Gary J.; Bradford, Charles; Wright, Edward L.; Zmuidzinas, Jonas; Origins Space Telescope Study Team

2017-01-01

The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. The renaming of the mission reflects Origins science goals that will discover and characterize the most distant galaxies, nearby galaxies and the Milky Way, exoplanets, and the outer reaches of our Solar system. This poster will show the preliminary telescope design that will be a large aperture (>8 m in diameter), cryogenically cooled telescope. We will also present the specifications for the spectrographs and imagers over a potential wavelength range of ~10 microns to 1 millimeter. We look forward to community input into this mission definition over the coming year as we work on the concept design for the mission. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at firsurveyor_info@lists.ipac.caltech.edu.

40 CFR 130.9 - Designation and de-designation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... QUALITY PLANNING AND MANAGEMENT § 130.9 Designation and de-designation. (a) Designation. Areawide planning... specified in Water Quality Management (WQM) plans. Areawide planning agencies shall monitor DMA activities... continue water quality planning activities within the designated boundaries. (c) Impact of de-designation...

Sense of agency in the human brain.

PubMed

Haggard, Patrick

2017-04-01

In adult life, people normally know what they are doing. This experience of controlling one's own actions and, through them, the course of events in the outside world is called 'sense of agency'. It forms a central feature of human experience; however, the brain mechanisms that produce the sense of agency have only recently begun to be investigated systematically. This recent progress has been driven by the development of better measures of the experience of agency, improved design of cognitive and behavioural experiments, and a growing understanding of the brain circuits that generate this distinctive but elusive experience. The sense of agency is a mental and neural state of cardinal importance in human civilization, because it is frequently altered in psychopathology and because it underpins the concept of responsibility in human societies.

76 FR 7482 - Operations Specifications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

...] RIN 2120-AJ45 Operations Specifications AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... carriers and foreign persons for part 129 operations specifications and establishes new standards for amendment, suspension, and termination of those operations specifications. In addition, the FAA has moved...

Designing Micro- and Nanoswimmers for Specific Applications.

PubMed

Katuri, Jaideep; Ma, Xing; Stanton, Morgan M; Sánchez, Samuel

2017-01-17

Self-propelled colloids have emerged as a new class of active matter over the past decade. These are micrometer sized colloidal objects that transduce free energy from their surroundings and convert it to directed motion. The self-propelled colloids are in many ways, the synthetic analogues of biological self-propelled units such as algae or bacteria. Although they are propelled by very different mechanisms, biological swimmers are typically powered by flagellar motion and synthetic swimmers are driven by local chemical reactions, they share a number of common features with respect to swimming behavior. They exhibit run-and-tumble like behavior, are responsive to environmental stimuli, and can even chemically interact with nearby swimmers. An understanding of self-propelled colloids could help us in understanding the complex behaviors that emerge in populations of natural microswimmers. Self-propelled colloids also offer some advantages over natural microswimmers, since the surface properties, propulsion mechanisms, and particle geometry can all be easily modified to meet specific needs. From a more practical perspective, a number of applications, ranging from environmental remediation to targeted drug delivery, have been envisioned for these systems. These applications rely on the basic functionalities of self-propelled colloids: directional motion, sensing of the local environment, and the ability to respond to external signals. Owing to the vastly different nature of each of these applications, it becomes necessary to optimize the design choices in these colloids. There has been a significant effort to develop a range of synthetic self-propelled colloids to meet the specific conditions required for different processes. Tubular self-propelled colloids, for example, are ideal for decontamination processes, owing to their bubble propulsion mechanism, which enhances mixing in systems, but are incompatible with biological systems due to the toxic propulsion fuel and

SLS-SPEC-159 Cross-Program Design Specification for Natural Environments (DSNE) Revision D

NASA Technical Reports Server (NTRS)

Roberts, Barry C.

2015-01-01

This document is derived from the former National Aeronautics and Space Administration (NASA) Constellation Program (CxP) document CxP 70023, titled "The Design Specification for Natural Environments (DSNE), Revision C." The original document has been modified to represent updated Design Reference Missions (DRMs) for the NASA Exploration Systems Development (ESD) Programs. The DSNE completes environment-related specifications for architecture, system-level, and lower-tier documents by specifying the ranges of environmental conditions that must be accounted for by NASA ESD Programs. To assure clarity and consistency, and to prevent requirements documents from becoming cluttered with extensive amounts of technical material, natural environment specifications have been compiled into this document. The intent is to keep a unified specification for natural environments that each Program calls out for appropriate application. This document defines the natural environments parameter limits (maximum and minimum values, energy spectra, or precise model inputs, assumptions, model options, etc.), for all ESD Programs. These environments are developed by the NASA Marshall Space Flight Center (MSFC) Natural Environments Branch (MSFC organization code: EV44). Many of the parameter limits are based on experience with previous programs, such as the Space Shuttle Program. The parameter limits contain no margin and are meant to be evaluated individually to ensure they are reasonable (i.e., do not apply unrealistic extreme-on-extreme conditions). The natural environments specifications in this document should be accounted for by robust design of the flight vehicle and support systems. However, it is understood that in some cases the Programs will find it more effective to account for portions of the environment ranges by operational mitigation or acceptance of risk in accordance with an appropriate program risk management plan and/or hazard analysis process. The DSNE is not intended

Integrating Cloud-Computing-Specific Model into Aircraft Design

NASA Astrophysics Data System (ADS)

Zhimin, Tian; Qi, Lin; Guangwen, Yang

Cloud Computing is becoming increasingly relevant, as it will enable companies involved in spreading this technology to open the door to Web 3.0. In the paper, the new categories of services introduced will slowly replace many types of computational resources currently used. In this perspective, grid computing, the basic element for the large scale supply of cloud services, will play a fundamental role in defining how those services will be provided. The paper tries to integrate cloud computing specific model into aircraft design. This work has acquired good results in sharing licenses of large scale and expensive software, such as CFD (Computational Fluid Dynamics), UG, CATIA, and so on.

Factors That Influence the Recruitment and Retention of Nurses in Public Health Agencies.

PubMed

Yeager, Valerie A; Wisniewski, Janna M

Given challenges to recruiting nurses to public health and the growth in national policies focused on population health, it is crucial that public health agencies develop strategies to sustain this important group of employees. The objective of this study was to examine factors that influence nurses' decisions to work in public health agencies. This cross-sectional study examined perspectives of nurses who worked in state and local public health departments and responded to the 2010 Council on Linkages Between Academia and Public Health Practice's survey of public health workers. We calculated the mean rating of each recruitment and retention factor for nurses and non-nurses separately and compared differences by using t tests. We then used multivariate regression analysis to examine differences in ratings by role (ie, nurse or non-nurse). After controlling for personal and organizational characteristics, the influence of 5 recruitment factors was significantly stronger among nurses than among non-nurses: flexibility of work schedule ( P < .001), autonomy/employee empowerment ( P < .001), ability to innovate ( P = .002), specific duties and responsibilities ( P = .005), and identifying with the mission of the organization ( P = .02). The influence of 5 retention factors was stronger among nurses than among non-nurses : autonomy/employee empowerment ( P < .001), flexibility of work schedule ( P < .001), specific duties and responsibilities ( P < .001), opportunities for training/continuing education ( P = .03), and ability to innovate ( P = .008). Some factors that influence nurses to begin and remain working in local governmental public health agencies, such as flexible schedules and employee autonomy, are factors that governmental public health agencies can design into positions and highlight when recruiting from health care organizations, private industry, and academia.

Design of patient-specific gait modifications for knee osteoarthritis rehabilitation.

PubMed

Fregly, Benjamin J; Reinbolt, Jeffrey A; Rooney, Kelly L; Mitchell, Kim H; Chmielewski, Terese L

2007-09-01

Abstract-Gait modification is a nonsurgical approach for reducing the external knee adduction torque in patients with knee osteoarthritis (OA). The magnitude of the first adduction torque peak in particular is strongly associated with knee OA progression. While toeing out has been shown to reduce the second peak, no clinically realistic gait modifications have been identified that effectively reduce both peaks simultaneously. This study predicts novel patient-specific gait modifications that achieve this goal without changing the foot path. The modified gait motion was designed for a single patient with knee OA using dynamic optimization of a patient-specific, full-body gait model. The cost function minimized the knee adduction torque subject to constraints limiting how much the new gait motion could deviate from the patient's normal gait motion. The optimizations predicted a "medial-thrust" gait pattern that reduced the first adduction torque peak between 32% and 54% and the second peak between 34% and 56%. The new motion involved three synergistic kinematic changes: slightly decreased pelvis obliquity, slightly increased leg flexion, and slightly increased pelvis axial rotation. After gait retraining, the patient achieved adduction torque reductions of 39% to 50% in the first peak and 37% to 55% in the second one. These reductions are comparable to those reported after high tibial osteotomy surgery. The associated kinematic changes were consistent with the predictions except for pelvis obliquity, which showed little change. This study demonstrates that it is feasible to design novel patient-specific gait modifications with potential clinical benefit using dynamic optimization of patient-specific, full-body gait models. Further investigation is needed to assess the extent to which similar gait modifications may be effective for other patients with knee OA.

75 FR 36067 - Agency Information Collection Activities; Proposed Collection; Comment Request; Chemical-Specific...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

... section 8(a) to evaluate the potential for adverse human health and environmental effects caused by the... Office (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200... technical information contact: Karen Chu, Chemical Control Division (7405M), Office of Pollution Prevention...

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

PubMed

Foight, Glenna Wink; Chen, T Scott; Richman, Daniel; Keating, Amy E

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model.

Improving Students' Conceptual Understanding of a Specific Content Learning: A Designed Teaching Sequence

ERIC Educational Resources Information Center

Ahmad, N. J.; Lah, Y. Che

2012-01-01

The efficacy of a teaching sequence designed for a specific content of learning of electrochemistry is described in this paper. The design of the teaching draws upon theoretical insights into perspectives on learning and empirical studies to improve the teaching of this topic. A case study involving two classes, the experimental and baseline…

Affective valence signals agency within and between individuals.

PubMed

Chang, Yen-Ping; Algoe, Sara B; Chen, Lung Hung

2017-03-01

Affective valence is a core component of all emotional experiences. Building on recent evidence and theory, we reason that valence informs individuals about their agency-the mental capability of doing and intending. Expressed affect may also lead to perceptions of agency by others. Supporting the hypothesis that valence influences self- and other-perception of agency, across 5 studies, we showed that participants perceived more agency in themselves in positive versus neutral and negative personal (Study 1) and interpersonal (Study 2) events. Participants also perceived more agency in fictional characters showing positive versus negative affect, regardless of how acceptable the characters' behavior was (Studies 3 and 4). Finally, we had participants personify 24 specific emotions across the valence dimension, and found that the more positive and less negative an emotion was, the more agency participants ascribed to the "person" (Study 5). We discuss the results in terms of how valence may help with human self- and social regulation. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

MODIS Information, Data, and Control System (MIDACS) system specifications and conceptual design

NASA Technical Reports Server (NTRS)

Han, D.; Salomonson, V.; Ormsby, J.; Ardanuy, P.; Mckay, A.; Hoyt, D.; Jaffin, S.; Vallette, B.; Sharts, B.; Folta, D.

1988-01-01

The MODIS Information, Data, and Control System (MIDACS) Specifications and Conceptual Design Document discusses system level requirements, the overall operating environment in which requirements must be met, and a breakdown of MIDACS into component subsystems, which include the Instrument Support Terminal, the Instrument Control Center, the Team Member Computing Facility, the Central Data Handling Facility, and the Data Archive and Distribution System. The specifications include sizing estimates for the processing and storage capacities of each data system element, as well as traffic analyses of data flows between the elements internally, and also externally across the data system interfaces. The specifications for the data system, as well as for the individual planning and scheduling, control and monitoring, data acquisition and processing, calibration and validation, and data archive and distribution components, do not yet fully specify the data system in the complete manner needed to achieve the scientific objectives of the MODIS instruments and science teams. The teams have not yet been formed; however, it was possible to develop the specifications and conceptual design based on the present concept of EosDIS, the Level-1 and Level-2 Functional Requirements Documents, the Operations Concept, and through interviews and meetings with key members of the scientific community.

The Sense of Agency Scale: A Measure of Consciously Perceived Control over One's Mind, Body, and the Immediate Environment

PubMed Central

Tapal, Adam; Oren, Ela; Dar, Reuven; Eitam, Baruch

2017-01-01

The sense of agency (SoA) is defined as “the registration that I am the initiator of my actions.” Both “direct” and “indirect” measurement of SoA has focused on specific contextualized perceptual events, however it has also been demonstrated that “higher level” cognitions seemingly affect the SoA. We designed a measure of person's general, context-free beliefs about having core agency—the Sense of Agency Scale (SoAS). An exploratory (EFA) and confirmatory (CFA) factor analyses on samples of 236 (Study 1) and 408 (Study 2) participants yielded two correlated factors we labeled Sense of Positive Agency (SoPA) and Sense of Negative Agency (SoNA). The construct validity of SoAS is demonstrated by its low-to-moderate correlations with conceptually relevant tools and by the moderate-strong relationship between the SoNA subscale and obsessive-compulsive (OC) symptoms (r = 0.35). We conclude that the SoAS seems to isolate people's general beliefs in their agency from their perceived success in obtaining outcomes. PMID:28955273

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.

PubMed

Berger, Stephanie; Procko, Erik; Margineantu, Daciana; Lee, Erinna F; Shen, Betty W; Zelter, Alex; Silva, Daniel-Adriano; Chawla, Kusum; Herold, Marco J; Garnier, Jean-Marc; Johnson, Richard; MacCoss, Michael J; Lessene, Guillaume; Davis, Trisha N; Stayton, Patrick S; Stoddard, Barry L; Fairlie, W Douglas; Hockenbery, David M; Baker, David

2016-11-02

Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhibitors specific for each BCL2 pro-survival protein. Following in vitro optimization, each inhibitor binds its target with high picomolar to low nanomolar affinity and at least 300-fold specificity. Expression of the designed inhibitors in human cancer cell lines revealed unique dependencies on BCL2 proteins for survival which could not be inferred from other BCL2 profiling methods. Our results show that designed inhibitors can be generated for each member of a closely-knit protein family to probe the importance of specific protein-protein interactions in complex biological processes.

Parents' and staff's support for a childcare agency employee mandatory vaccination policy or agency certification program.

PubMed

Rebmann, Terri; Wang, Jing; Wilson, Kristin D; Gilbertson, Philip G; Wakefield, Mary

2016-07-01

Vaccine-preventable diseases pose a significant risk to children in childcare. However, few regulations exist regarding childcare staff vaccination. This study aimed to assess support for a childcare agency staff mandatory vaccination policy. Surveys were distributed to staff and parents at 23 St Louis, Mo, childcare agencies during fall 2014. Staff and parents' support for a mandatory vaccination and/or agency certification program were compared using χ(2) tests. Multivariate logistic regression was conducted using a 2-level nested design and controlling for gender, race, age, and income to determine predictive models for support for a mandatory staff vaccination policy and/or agency certification program. Overall, 354 parents and staff participated (response rate, 32%). Most supported a mandatory staff vaccination policy (80.0%; n = 280) or agency certification program (81.2%; n = 285), and there were no differences between parents versus staff. Determinants of support for a mandatory policy included willingness to receive influenza vaccine annually, belief that vaccines are safe and effective, and support for the policy only if there were no costs. There is strong support for some type of childcare agency staff vaccination policy. Implementing such a policy/program should be a collaborative endeavor that addresses vaccine cost and access. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.

Epistemological Agency in the Workplace

ERIC Educational Resources Information Center

Smith, Raymond

2006-01-01

Purpose: The purpose of this paper is to report and discuss research that sought to explore how the individually purposeful nature of new employee workplace learning might be understood through its conception as epistemological agency, that is, the personally mediated construction of knowledge. Design/methodology/approach: Using a sociocultural…

Designing patient-specific 3D printed craniofacial implants using a novel topology optimization method.

PubMed

Sutradhar, Alok; Park, Jaejong; Carrau, Diana; Nguyen, Tam H; Miller, Michael J; Paulino, Glaucio H

2016-07-01

Large craniofacial defects require efficient bone replacements which should not only provide good aesthetics but also possess stable structural function. The proposed work uses a novel multiresolution topology optimization method to achieve the task. Using a compliance minimization objective, patient-specific bone replacement shapes can be designed for different clinical cases that ensure revival of efficient load transfer mechanisms in the mid-face. In this work, four clinical cases are introduced and their respective patient-specific designs are obtained using the proposed method. The optimized designs are then virtually inserted into the defect to visually inspect the viability of the design . Further, once the design is verified by the reconstructive surgeon, prototypes are fabricated using a 3D printer for validation. The robustness of the designs are mechanically tested by subjecting them to a physiological loading condition which mimics the masticatory activity. The full-field strain result through 3D image correlation and the finite element analysis implies that the solution can survive the maximum mastication of 120 lb. Also, the designs have the potential to restore the buttress system and provide the structural integrity. Using the topology optimization framework in designing the bone replacement shapes would deliver surgeons new alternatives for rather complicated mid-face reconstruction.

Enriching peptide libraries for binding affinity and specificity through computationally directed library design

PubMed Central

Foight, Glenna Wink; Chen, T. Scott; Richman, Daniel; Keating, Amy E.

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model. PMID:28236241

Analytical Tools for Space Suit Design

NASA Technical Reports Server (NTRS)

Aitchison, Lindsay

2011-01-01

As indicated by the implementation of multiple small project teams within the agency, NASA is adopting a lean approach to hardware development that emphasizes quick product realization and rapid response to shifting program and agency goals. Over the past two decades, space suit design has been evolutionary in approach with emphasis on building prototypes then testing with the largest practical range of subjects possible. The results of these efforts show continuous improvement but make scaled design and performance predictions almost impossible with limited budgets and little time. Thus, in an effort to start changing the way NASA approaches space suit design and analysis, the Advanced Space Suit group has initiated the development of an integrated design and analysis tool. It is a multi-year-if not decadal-development effort that, when fully implemented, is envisioned to generate analysis of any given space suit architecture or, conversely, predictions of ideal space suit architectures given specific mission parameters. The master tool will exchange information to and from a set of five sub-tool groups in order to generate the desired output. The basic functions of each sub-tool group, the initial relationships between the sub-tools, and a comparison to state of the art software and tools are discussed.

1 CFR 16.1 - Designation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 1 General Provisions 1 2011-01-01 2011-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An authorizing...

1 CFR 16.1 - Designation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An authorizing...

1 CFR 16.1 - Designation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An authorizing...

1 CFR 16.1 - Designation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 1 General Provisions 1 2012-01-01 2012-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An authorizing...

1 CFR 16.1 - Designation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An authorizing...

Better Educational Website Interface Design: The Implications from Gender-Specific Preferences in Graduate Students

ERIC Educational Resources Information Center

Hsu, Yu-chang

2006-01-01

This study investigated graduate students gender-specific preferences for certain website interface design features, intending to generate useful information for instructors in choosing and for website designers in creating educational websites. The features investigated in this study included colour value, major navigation buttons placement, and…

Community Agency Survey Formative Research Results From the TAAG Study

PubMed Central

Saunders, Ruth P.; Moody, Jamie

2008-01-01

School and community agency collaboration can potentially increase physical activity opportunities for youth. Few studies have examined the role of community agencies in promoting physical activity, much less in collaboration with schools. This article describes formative research data collection from community agencies to inform the development of the Trial of Activity for Adolescent Girls (TAAG) intervention to provide out-of-school physical activity programs for girls. The community agency survey is designed to assess agency capacity to provide physical activity programs for girls, including resources, programs, and partnerships. Most agency respondents (n = 138) report operations during after-school hours, adequate facilities, and program options for girls, although most are sport oriented. Agency resources and programming vary considerably across the six TAAG field sites. Many agencies report partnerships, some involving schools, although not necessarily related to physical activity. Implications for the TAAG intervention are presented. PMID:16397156

34 CFR 300.28 - Local educational agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.28 Local educational agency. (a... the extent that the inclusion makes the school eligible for programs for which specific eligibility is...

13 CFR 147.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Federal agency or agency. 147.645 Section 147.645 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Definitions § 147.645 Federal agency or agency. Federal...

Enhancing personal agency and competence in eating and moving: formative evaluation of a middle school curriculum--Choice, Control, and Change.

PubMed

Contento, Isobel R; Koch, Pamela A; Lee, Heewon; Sauberli, Wendy; Calabrese-Barton, Angela

2007-01-01

The purpose of this formative evaluation was to examine the impact of an innovative inquiry-based science education curriculum for middle school students, called Choice, Control, and Change, that is designed to foster healthful eating and physical activity and a healthy weight through enhancing agency and competence. The 24-session curriculum helps students develop understandings about the interactions between biology, personal behavior, and the environment and personal agency through cognitive self-regulation skills in navigating today's complex food system and sedentary environment. An extended theory of planned behavior served as the design framework. The study used a pretest-posttest evaluation design involving 278 middle school students in 19 science classes within 5 schools. Based on paired t tests, students significantly improved on several curriculum-specific eating and physical activity behaviors: they decreased several sedentary activities and increased their frequencies of fruit and vegetable intake. They decreased the frequency of sweetened beverages, packaged snacks, and eating at a fast-food restaurant, and ate and drank smaller portions of some items. Their outcome beliefs and overall self-efficacy, but not their attitudes, became more positive. A strategy based on fostering personal agency, cognitive self-regulation, and competence can be effective in increasing healthful eating and physical activity behaviors in middle school children and should be explored further.

Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids

DOE PAGES

Lau, King Hang Aaron; Sileika, Tadas S.; Park, Sung Hyun; ...

2014-11-26

Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platformmore » for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. In conclusion, the results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.« less

7 CFR 3560.505 - Agency loans to finance purchases of REO properties.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Agency loans to finance purchases of REO properties... Disposition of Real Estate Owned (REO) Properties § 3560.505 Agency loans to finance purchases of REO properties. (a) Agency loans to finance the purchase of REO property designated to be sold as program...

7 CFR 3560.505 - Agency loans to finance purchases of REO properties.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Agency loans to finance purchases of REO properties... Disposition of Real Estate Owned (REO) Properties § 3560.505 Agency loans to finance purchases of REO properties. (a) Agency loans to finance the purchase of REO property designated to be sold as program...

7 CFR 3560.505 - Agency loans to finance purchases of REO properties.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Agency loans to finance purchases of REO properties... Disposition of Real Estate Owned (REO) Properties § 3560.505 Agency loans to finance purchases of REO properties. (a) Agency loans to finance the purchase of REO property designated to be sold as program...

7 CFR 3560.505 - Agency loans to finance purchases of REO properties.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Agency loans to finance purchases of REO properties... Disposition of Real Estate Owned (REO) Properties § 3560.505 Agency loans to finance purchases of REO properties. (a) Agency loans to finance the purchase of REO property designated to be sold as program...

77 FR 69507 - Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

..., ``Revise Shutdown Margin Definition To Address Advanced Fuel Designs'' AGENCY: Nuclear Regulatory... Shutdown Margin Definition to Address Advanced Fuel Designs.'' DATES: Comment period expires on December 19... address newer BWR fuel designs, which may be more reactive at shutdown temperatures above 68[emsp14][deg]F...

10 CFR 607.645 - Federal agency or agency.

Code of Federal Regulations, 2010 CFR