Science.gov

Sample records for agency nuclear regulatory

  1. Court-agency interaction in environmental policymaking: the cases of the Nuclear Regulatory Commission and the Environmental Protection Agency

    SciTech Connect

    Thomas, L.W.

    1981-01-01

    This study examines the increasingly active participation of courts in the administrative process as well as agency responses to court-imposed policy shifts. More specifically, it is an investigation of the interaction between the federal courts, primarily the Supreme Court and the District of Columbia Court of Appeals, and two federal regulatory agencies, the Nuclar Regulatory Commission and the Environmental Protection Agency. There are five objectives to the study. The first is to examine the natura of court-agency interaction and to determine the extent to which patterns of judicial review of administrative actions can be discerned. The second is to examine the effect of court orders on agency programs and policies. The third is to assess the anticipatory dimension of court-agency relations. The fourth is to inquire into the recurring dimension of court-agency interaction and to determine its effect on subsequent court decisions. The last is to assess the institutional capacity of courts to deal with scientific and technological issues. This study indicates that judicial review has a substantial effect on the NRC's and the EPA's decision-making activities. Few, if any, recent major policy decisions of the two agencies have not been scrutinized closely by federal appellate courts. During the past decade, the courts have blocked policy initiative on numerous occasions and have been the primary source of change in others. In addition, the mere anticipation of judicial review was found to be a factor motivating the two agencies to make reasoned decisions.

  2. 78 FR 44165 - Nuclear Regulatory Commission Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Nuclear Regulatory Commission Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Enforcement policy; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is...

  3. 76 FR 77855 - Criteria for Identifying Material Licensees for the U. S. Nuclear Regulatory Commission's Agency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... issues were published for comment on September 9, 2010 (75 FR 54917). The comment period ended on October... the reactor oversight process (ROP) action matrix, (2) to review the appropriateness of agency actions... review of approved deviations from the action matrix, and (5) to ensure that trends in industry...

  4. Nuclear Regulatory Commission information digest

    SciTech Connect

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  5. 78 FR 45573 - Compensatory and Alternative Regulatory Measures for Nuclear Power Plant Fire Protection (CARMEN...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... COMMISSION Compensatory and Alternative Regulatory Measures for Nuclear Power Plant Fire Protection (CARMEN-FIRE) AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability; request for public comment.../CR-7135, ``Compensatory and Alternative Regulatory Measures for Nuclear Power Plant Fire...

  6. Regulatory beneficiaries and informal agency policymaking.

    PubMed

    Mendelson, Nina A

    2007-03-01

    Administrative agencies frequently use guidance documents to set policy broadly and prospectively in areas ranging from Department of Education Title IX enforcement to Food and Drug Administration regulation of direct-to- consumer pharmaceutical advertising. In form, these guidances often closely resemble the policies agencies issue in ordinary notice-and-comment rulemaking. However, guidances are generally developed with little public participation and are often immune from judicial review. Nonetheless, guidances can prompt significant changes in behavior from those the agencies regulate. A number of commentators have guardedly defended the current state of affairs. Though guidances lack some important procedural safeguards, they can help agencies supervise low-level employees and supply valuable information to regulated entities regarding how an agency will implement a program. Thus far, however, the debate has largely ignored the distinct and substantial interests of regulatory beneficiaries--those who expect to benefit from government regulation of others. Regulatory beneficiaries include, among others, pharmaceutical consumers, environmental users, and workers seeking safe workplaces. When agencies make policy informally, regulatory beneficiaries suffer distinctive losses to their ability to participate in the agency's decision and to invoke judicial review. This Article argues that considering the interests of regulatory beneficiaries strengthens the case for procedural reform. The Article then assesses some possible solutions. PMID:17410678

  7. ASSESSMENT OF CAPABILITIES AND RESEARCH NEEDS IN THE AREA OF HEALTH EFFECTS OF LOW-LEVEL IONIZING RADIATION: A JOINT REPORT TO THE CONGRESS BY THE U.S. ENVIRONMENTAL PROTECTION AGENCY, AND THE U.S. NUCLEAR REGULATORY COMMISSION

    EPA Science Inventory

    The report summarizes the capabilities, research needs and on-going projects of the Environmental Protection Agency and the Nuclear Regulatory Commission related to the health effects of low-level ionizing radiation. The statutory authorities of both EPA and NRC related to radiat...

  8. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... April 9, 1985 (published April 18, 1985, 50 FR 15485), and published as Appendix A to 44 CFR part 353... a specific nuclear power plant site. If the review involves an application under 10 CFR part 52 for... correct exercise deficiencies; (6) correlation of FEMA actions on withdrawal of approvals under 44...

  9. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... April 9, 1985 (published April 18, 1985, 50 FR 15485), and published as Appendix A to 44 CFR part 353... a specific nuclear power plant site. If the review involves an application under 10 CFR part 52 for... correct exercise deficiencies; (6) correlation of FEMA actions on withdrawal of approvals under 44...

  10. Nuclear Regulatory Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...) 2010, less the amounts appropriated from the Nuclear Waste Fund, amounts appropriated for Waste... agenda on April 26, 2010 (75 FR 21960). For this edition of the NRC's regulatory agenda, the most... publication of the last NRC semiannual agenda on April 26, 2010 (75 FR 21960). Within each group, the...

  11. Nuclear Regulatory Commission Information Digest, 1991 edition

    SciTech Connect

    Olive, K L

    1991-03-01

    The Nuclear Regulatory Commission Information Digest provides a summary of information about the US Nuclear Regulatory Commission (NRC), NRC's regulatory responsibilities, and the areas NRC licenses. This digest is a compilation of NRC-related data and is designed to provide a quick reference to major facts about the agency and the industry it regulates. In general, the data cover 1975 through 1990, with exceptions noted. For operating US commercial nuclear power reactors, information on generating capacity and average capacity factor is obtained from Monthly Operating Reports submitted to the NRC directly by the licensee. This information is reviewed for consistency only. No independent validation and/or verification is performed by the NRC. For detailed and complete information about tables and figures, refer to the source publications. This digest is published annually for the general use of the NRC staff and is available to the public. 30 figs., 12 tabs.

  12. Nuclear Regulatory Commission issuances

    SciTech Connect

    1996-04-01

    This report includes the issuances received during the April 1996 reporting period from the Commission, the Atomic Safety and Licensing Boards, the Administrative Law Judges, the Directors` Decisions, and the Decisions on Petitions for Rulemaking. Included are issuances pertaining to: (1) Yankee Nuclear Power Station, (2) Georgia Tech Research Reactor, (3) River Bend Station, (4) Millstone Unit 1, (5) Thermo-Lag fire barrier material, and (6) Louisiana Energy Services.

  13. Nuclear Regulatory Commission 1989 Information Digest

    SciTech Connect

    None,

    1989-03-01

    The Nuclear Regulatory Commission 1989 Information Digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the Commission. This is the first of an annual publication for the general use of the NRC staff and is available to the public. The Digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  14. 5 CFR 1320.15 - Independent regulatory agency override authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a)...

  15. 5 CFR 1320.15 - Independent regulatory agency override authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a)...

  16. 5 CFR 1320.15 - Independent regulatory agency override authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a)...

  17. 5 CFR 1320.15 - Independent regulatory agency override authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a)...

  18. 5 CFR 1320.15 - Independent regulatory agency override authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a)...

  19. Department of Transportation Agency Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... accordance with Executive Order 12866 ``Regulatory Planning and Review'' (58 FR 51735; October 4, 1993) and the Department's Regulatory Policies and Procedures (44 FR 11034; February 26, 1979), the Department... last agenda was published in the Federal Register on April 26, 2010 (75 FR 21840). The next one...

  20. Environmental Protection Agency Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...:// Not in FR www.epa.gov/lawsregs/search/regagenda.html Semiannual Regulatory Flexibility Agenda www....html issue ] Monthly Action Initiation List http://www.regulations.gov/fdmspublic/component/ Not in FR... Rulemaking Gateway www.epa.gov/rulemaking/ Not in FR B. What Are EPA's Regulatory Goals, and What...

  1. 78 FR 55765 - Compensatory and Alternative Regulatory Measures for Nuclear Power Plant Fire Protection (CARMEN...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... (78 FR 45573) a request for public comment on NUREG/CR-7135, ``Compensatory and Alternative Regulatory... COMMISSION Compensatory and Alternative Regulatory Measures for Nuclear Power Plant Fire Protection (CARMEN-FIRE) AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG/CR, reopening of comment...

  2. Nuclear Regulatory Commission Information Digest 1994 edition. Volume 6

    SciTech Connect

    Stadler, L.

    1994-03-01

    The Nuclear Regulatory Commission Information Digest (digest) provides a summary of information about the US Nuclear Regulatory Commission (NRC), NRCs regulatory responsibility the activities NRC licenses, and general information on domestic and worldwide nuclear energy. The digest, published annually, is a compilation of nuclear-and NRC-related data and is designed to provide a quick reference to major facts about the agency and the industry it regulates. In general, the data cover 1975 through 1993, with exceptions noted. Information on generating capacity and average capacity factor for operating US commercial nuclear power reactors is obtained from monthly operating reports that are submitted directly to the NRC by the information is reviewed by the NRC for consistency only and no independent validation and/or verification is performed.

  3. Nuclear Regulatory Commission Information Digest 1992 edition. Volume 4

    SciTech Connect

    Olive, K

    1992-03-01

    The Nuclear Regulatory Commission Information Digest provides a summary of information about the US Nuclear Regulatory Commission (NRC), NRC's regulatory responsibilities, the activities NRC licenses, and general information on domestic and worldwide nuclear energy. This digest is a compilation of nuclear- and NRC-related data and is designed to provide a quick reference to major facts about the agency and industry it regulates. In general, the data cover 1975 through 1991, with exceptions noted. Information on generating capacity and average capacity factor for operating US commercial nuclear power reactors is obtained from monthly operating reports that are submitted directly to the NRC by the licensee. This information is reviewed by the NRC for consistency only and no independent validation and/or verification is performed.

  4. Nuclear Regulatory Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... amounts appropriated from the Nuclear Waste Fund, amounts appropriated for Waste Incidental to... December 7, 2009 (74 FR 64572). ADDRESSES: Comments on any rule in the agenda may be sent to the Secretary... occurred on rules since publication of the last NRC semiannual agenda on December 7, 2009 (74 FR...

  5. Information resources in state regulatory agencies-a California perspective

    SciTech Connect

    DiZio, S.M.

    1990-12-31

    Various state regulatory agencies have expressed a need for networking with information gatherers/researchers to produce a concise compilation of primary information so that the basis for regulatory standards can be scientifically referenced. California has instituted several programs to retrieve primary information, generate primary information through research, and generate unique regulatory standards by integrating the primary literature and the products of research. This paper describes these programs.

  6. 77 FR 8902 - Draft Regulatory Guide: Issuance, Availability Decommissioning of Nuclear Power Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability Decommissioning of Nuclear Power Reactors AGENCY... ``Decommissioning of Nuclear Power Reactors.'' This guide describes a method NRC considers acceptable for use in... Revision 1 of Regulatory Guide 1.184, ``Decommissioning of Nuclear Power Reactors,'' dated July 2000....

  7. Environmental Protection Agency Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... , and http:// Not in FR www.epa.gov/lawsregs/search/regagenda.html ] FY 2011 Regulatory Plan Go to.../fdmspublic/component/ Not in FR main?main=DocketDetail& d=EPA-HQ-OA-2008-0265 and http:// www.epa.gov/lawsregs/search/ail.html Rulemaking Gateway www.epa.gov/rulemaking/ Not in FR B. What Are EPA's...

  8. 76 FR 61402 - Draft Nuclear Regulatory Commission Fiscal Year 2012-2016 Strategic Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ...The U.S. Nuclear Regulatory Commission (NRC) is announcing the availability of and requesting comment on draft NUREG-1614, Volume 5. ``U.S. Nuclear Regulatory Commission, FY 2012-2016 Strategic Plan,'' dated September 2011. The NRC's draft FY 2012-2016 strategic plan describes the agency's mission and strategic objective, which remain unchanged. The NRC's priority continues to be ensuring the......

  9. 75 FR 1088 - Notice of Availability of a Memorandum of Understanding Between the Nuclear Regulatory Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... and the Bureau of Land Management AGENCY: Nuclear Regulatory Commission. ACTION: Notice of.... Introduction The Nuclear Regulatory Commission (NRC) and the Bureau of Land Management (BLM) have finalized a..., or by e-mail to pdr.resource@nrc.gov . The ``Memorandum of Understanding between the Bureau of...

  10. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory...

  11. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory...

  12. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research— (a) Plans, recommends, and implements...

  13. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory...

  14. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory...

  15. Papers on the nuclear regulatory dilemma

    SciTech Connect

    Barkenbus, J.N.; Freeman, S.D.; Weinberg, A.M.

    1985-10-01

    The four papers contained in this report are titled: (1) From Prescriptive to Performance-Based Regulation of Nuclear Power; (2) Nuclear Regulatory Reform: A Technology-Forcing Approach; (3) Improving the Regulation of Nuclear Power; and (4) Science and Its Limits: The Regulators' Dilemma. These four papers investigate issues relating to the long-term regulation of nuclear energy. They were prepared as part of the Institute for Energy Analysis' project on Nuclear Regulation funded by a grant from the Mellon Foundation and a smaller grant by the MacArthur Foundation. Originally this work was to be supplemented by contributions from the Nuclear Regulatory Commission and from the Department of Energy. These contributions were not forthcoming, and as a result the scope of our investigations was more restricted than we had originally planned.

  16. 75 FR 11166 - Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission; Notice of Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission March 2,...

  17. Reaching site closure for groundwater under multiple regulatory agencies

    SciTech Connect

    Glucksberg, N.; Couture, B.

    2007-07-01

    Groundwater at the Connecticut Yankee Atomic Power Company (CYAPCO) Haddam Neck Plant (HNP) has been impacted by both radionuclides and chemical constituents. Furthermore, the cleanup standards and closure requirements for HNP are regulated both by federal and state agencies. The only consistent requirement is the development of a site conceptual model and an understanding of the hydrogeologic conditions that will govern contaminant transport and identify potential receptors. The cleanup criteria to reach site closure for radionuclides is regulated by both the Nuclear Regulatory Commission (NRC) and the Connecticut Department of Environmental Protection (CTDEP) Bureau of Air Management, Radiological Division. For license termination under the NRC, the total effective dose equivalent (TEDE) for all media can not exceed 25 milli-Rem per year (mRem/yr) plus As Low as Reasonably Achievable (ALARA). The CTDEP has a similar requirement with the TEDE not to exceed 19 mRem/yr plus ALARA. To reach these criteria, derived concentration guideline levels (DCGLs) were developed for radiological exposures from three (3) media components; soil, existing groundwater and future groundwater from left-in place foundations or footings. Based on current conditions, the target dose contribution from existing and future groundwater is not to exceed 2 mRem/yr TEDE. After source (soil) remediation is complete, the NRC requires two (2) years of quarterly monitoring to demonstrate that groundwater quality meets the DCGLs and does not show an upward trend. CYAPCO's NRC License Termination Plan (LTP) specifies a minimum 18-month period of groundwater monitoring, as long as samples are collected during two spring/high water seasons, to verify the efficacy of remedial actions at HNP. In addition to the 19 mRem/yr criteria, the CTDEP also requires groundwater to be in compliance with the Remediation Standards Regulation (RSRs). There are no published criteria for radionuclides in the RSRs

  18. The Role of Regulatory Agencies and Intellectual Property: Part I.

    PubMed

    Noonan, Kevin E

    2015-07-01

    The patent and regulatory regimes of different agencies of the federal government are not always in agreement, and although the concept of the "unified executive" holds that the executive branch speaks with one voice, that is not always the case.(1) Some agencies, like the Food and Drug Administration, tend toward cooperation with government patent policies, whereas others, notably the Federal Trade Commission, are often at odds with the Patent Office, the patent system, or both. These skirmishes, when they arise, eventually come before federal courts and ultimately the Supreme Court, where balancing the differing policy objectives, as well as the will of Congress as embodied in its statutes, is subject to the vagaries of the politics of how the issues are framed by the courts, and the judges' and justices' own predilections and prejudices. Examples of these situations were prevalent in 2013 and the circumstances surrounding them illustrative of the tensions inherent between the various federal agencies. PMID:25775921

  19. 76 FR 31997 - Final Memorandum of Understanding Between the U.S. Nuclear Regulatory Commission and the U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Final Memorandum of Understanding Between the U.S. Nuclear Regulatory Commission and the U.S. Department of Homeland Security on Chemical Facility Anti-Terrorism Standards AGENCY: Nuclear...

  20. Reaching Site Closure for Groundwater under Multiple Regulatory Agencies

    SciTech Connect

    Glucksberg, N.; Shephard, Gene; Peters, Jay; Couture, B.

    2008-01-15

    Groundwater at the Connecticut Yankee Atomic Power Company (CYAPCO) Haddam Neck Plant (HNP) requires investigation of both radionuclides and chemical constituents in order to achieve closure. Cleanup criteria for groundwater are regulated both by federal and state agencies. These requirements vary in both numerical values as well as the duration of post remediation monitoring. The only consistent requirement is the development of a site conceptual model and an understanding of the hydrogeologic conditions that will govern contaminant transport and identify potential receptors. To successfully reach closure under each agency, it is paramount to understand the different requirements during the planning stages of the investigation. Therefore, the conceptual site model, groundwater transport mechanisms, and potential receptors must be defined. Once the hydrogeology is understood, a long term groundwater program can then be coordinated to meet each regulatory agency requirement to both terminate the NRC license and reach site closure under RCRA. Based on the different criteria, the CTDEP-LR (or RSR criteria) are not only bounding, but also requires the longest duration. As with most decommissioning efforts, regulatory attention is focused on the NRC, however, with the recent industry initiatives based on concern of tritium releases to groundwater at other plants, it is likely that the USEPA and state agencies may continue to drive site investigations. By recognizing these differences, data quality objectives can include all agency requirements, thus minimizing rework or duplicative efforts. CYAPCO intends to complete groundwater monitoring for the NRC and CTDEP-RD by July 2007. However, because shallow remediations are still being conducted, site closure under USEPA and CTDEP-LR is projected to be late 2011.

  1. 44 CFR 351.21 - The Nuclear Regulatory Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false The Nuclear Regulatory... Assignments § 351.21 The Nuclear Regulatory Commission. (a) Assess NRC nuclear facility (e.g., commercial... protect the health and safety of the public. (b) Verify that nuclear facility licensee emergency plans...

  2. 44 CFR 351.21 - The Nuclear Regulatory Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false The Nuclear Regulatory... Assignments § 351.21 The Nuclear Regulatory Commission. (a) Assess NRC nuclear facility (e.g., commercial... protect the health and safety of the public. (b) Verify that nuclear facility licensee emergency plans...

  3. 44 CFR 351.21 - The Nuclear Regulatory Commission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true The Nuclear Regulatory... Assignments § 351.21 The Nuclear Regulatory Commission. (a) Assess NRC nuclear facility (e.g., commercial... protect the health and safety of the public. (b) Verify that nuclear facility licensee emergency plans...

  4. 44 CFR 351.21 - The Nuclear Regulatory Commission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false The Nuclear Regulatory... Assignments § 351.21 The Nuclear Regulatory Commission. (a) Assess NRC nuclear facility (e.g., commercial... protect the health and safety of the public. (b) Verify that nuclear facility licensee emergency plans...

  5. 44 CFR 351.21 - The Nuclear Regulatory Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false The Nuclear Regulatory... Assignments § 351.21 The Nuclear Regulatory Commission. (a) Assess NRC nuclear facility (e.g., commercial... protect the health and safety of the public. (b) Verify that nuclear facility licensee emergency plans...

  6. 78 FR 57668 - U.S. Nuclear Regulatory Commission Planned for Monitoring Activities for the Saltstone Disposal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    .... Department of Energy at the Savannah River Site Saltstone Disposal Facility in Accordance With the National... COMMISSION U.S. Nuclear Regulatory Commission Planned for Monitoring Activities for the Saltstone Disposal Facility at the Savannah River Site, Revision 1 AGENCY: Nuclear Regulatory Commission. ACTION: Notice...

  7. Nuclear Regulatory Commission Issuances: Opinions and decisions of the Nuclear Regulatory Commission with selected orders. Progress report, January 1, 1996--June 30, 1996. Volume 43, pages 1-358

    SciTech Connect

    1997-05-01

    The hardbound edition of the Nuclear Regulatory Issuances is a final compilation of the monthly issuances. It includes all legal precedents for the agency within a six month period. This is the forty-third volume of issuances.

  8. Re-evaluation of Non-regulatory Asbestos Group Minerals for Regulatory Agencies

    NASA Astrophysics Data System (ADS)

    Dogan, M.; Dogan, A.

    2013-05-01

    Agencies should oversea "positive" identification guidelines followed closely for non-regulatory asbestos group minerals.

  9. 3 CFR 13579 - Executive Order 13579 of July 11, 2011. Regulation and Independent Regulatory Agencies

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Executive Order 13579 of July 11, 2011. Regulation and Independent Regulatory Agencies 13579 Order 13579 Presidential Documents Executive Orders Executive Order 13579 of July 11, 2011 EO 13579 Regulation and Independent Regulatory Agencies By the authority vested in me as President by the...

  10. Regulatory review: How do agencies ensure the quality of decision making?

    PubMed

    Liberti, L; McAuslane, N; Patel, P; Breckenridge, A; Eichler, H G; Peterson, R

    2013-09-01

    The Centre for Innovation in Regulatory Science (CIRS) Workshop on Regulatory Review brought together international regulators and multinational pharmaceutical company representatives to focus on best practices that underlie regulatory decision making, thereby facilitating the transparent, timely, procedurally predictable, and good-quality evaluation of new medicines. Participants investigated frameworks used by agencies, discussed challenges for regulatory agencies in making quality decisions, investigated the role of other stakeholders, and made recommendations of activities and processes that agencies and companies can consider to enable quality decision making. PMID:23963218

  11. 75 FR 62893 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1196, ``Qualification for Cement... Commission (NRC) is issuing for public comment a draft guide in the agency's ``Regulatory Guide''...

  12. KWOC (Key-Word-Out-of-Context) Index of US Nuclear Regulatory Commission Regulatory Guide Series

    SciTech Connect

    Jennings, S.D.

    1990-04-01

    To meet the objectives of the program funded by the Department of Energy (DOE)-Nuclear Energy (NE) Technology Support Programs, the Performance Assurance Project Office (PAPO) administers a Performance Assurance Information Program that collects, compiles, and distributes program-related information, reports, and publications for the benefit of the DOE-NE program participants. THE KWOC Index of US Nuclear Regulatory Commission Regulatory Guide Series'' is prepared as an aid in searching for specific topics in the US Nuclear Regulatory Commission, Regulatory Guide Series.

  13. 77 FR 34379 - Notice of Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission The Federal Energy Regulatory Commission (FERC) and the Nuclear Regulatory Commission (NRC) will hold a...

  14. 76 FR 32878 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ...; ] NUCLEAR REGULATORY COMMISSION 10 CFR Part 50 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1253, ``Preoperational Testing of Emergency Core Cooling Systems for Pressurized-Water Reactors''....

  15. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content...

  16. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content...

  17. 76 FR 50274 - Terrestrial Environmental Studies for Nuclear Power Stations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Terrestrial Environmental Studies for Nuclear Power Stations AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission...

  18. Quantitative Characterization Guidelines of Erionite Series Minerals for Regulatory Agencies

    NASA Astrophysics Data System (ADS)

    Dogan, A.; Dogan, M.

    2013-05-01

    Erionite is a major health problem where contaminates an environment, which human population exists. Erionite - mesothelioma relationship was first observed in Turkey in 1980's and now the problem is emerging in other places in the world including Mexico. In the past, there have been in vivo or in vitro biological experiments performed using "not correctly characterized" erionite minerals. In addition, in 1997, the erionite was elevated to series status and new erionite minerals - erionite-Na, -K, -Ca - have been proposed. In 2008, erionite characterization guidelines have been proposed (Dogan and Dogan, 2008) and using these criteria, published data was re-evaluated and re-classified; and new mean chemical formula of erionite-Na, -K, -Ca was proposed. If data do not pass the E% and Mg-tests, then any reference to them in the literature is proposed to be disregarded. In some cases, different results have been reported for erionites from the same location by different authors. In these cases, if data do pass both tests but are characterized as from more than one type of erionite, then the mineral should be classified as "undifferentiated" until further clarification. Therefore, we propose (i) Erionite should be correctly characterized using proposed "positive" identification guidelines. (ii) Erionite species (whether it is -Na or -K or -Ca) should be correctly identified. (iii) There should be a close collaboration between medical community researchers and mineralogists in this field so that animal and cell experiments should be performed only with minerals that have passed "positive" identification tests. (iv) An international data bank should be established at one of the mineralogical societies and new data must be evaluated rigorously before being accepted. (v) Regulatory Agencies should ensure that the proposed guidelines for "positive" identification of erionite series minerals, both for a single fiber and a bulk mineral, are followed closely. (vi) Finally, the

  19. Nuclear Regulatory Commission issuances, January 1997. Volume 45, Number 1

    SciTech Connect

    1997-01-01

    This book contains issuances of the Atomic Safety and Licensing Board, Nuclear Regulatory Commission and Director`s Decision for January 1997. The issuances concern Sequoyah Fuels Corporation and General Atomics Gore, Oklahoma Site decontamination and decommissioning funding; Louisiana Energy Services, Claiborne Enrichment Center denies appeal to review emergency planning; General Public Utilities Nuclear Corporation, Oyster Creek Nuclear Generating station, challenges to technical specifications concerning spent fuel pool; and Consumers Power Company, Palisades Nuclear Plant dry cask storage of spent nuclear fuel.

  20. The Regulatory Challenges of Decommissioning Nuclear Power Plants in Korea - 13101

    SciTech Connect

    Lee, Jungjoon; Ahn, Sangmyeon; Choi, Kyungwoo; Kim, Juyoul; Kim, Juyub

    2013-07-01

    As of 2012, 23 units of nuclear power plants are in operation, but there is no experience of permanent shutdown and decommissioning of nuclear power plant in Korea. It is realized that, since late 1990's, improvement of the regulatory framework for decommissioning has been emphasized constantly from the point of view of International Atomic Energy Agency (IAEA)'s safety standards. And it is known that now IAEA prepare the safety requirement on decommissioning of facilities, its title is the Safe Decommissioning of Facilities, General Safety Requirement Part 6. According to the result of IAEA's Integrated Regulatory Review Service (IRRS) mission to Korea in 2011, it was recommended that the regulatory framework for decommissioning should require decommissioning plans for nuclear installations to be constructed and operated and these plans should be updated periodically. In addition, after the Fukushima nuclear disaster in Japan in March of 2011, preparedness for early decommissioning caused by an unexpected severe accident became also important issues and concerns. In this respect, it is acknowledged that the regulatory framework for decommissioning of nuclear facilities in Korea need to be improved. First of all, we identify the current status and relevant issues of regulatory framework for decommissioning of nuclear power plants compared to the IAEA's safety standards in order to achieve our goal. And then the plan is to be established for improvement of regulatory framework for decommissioning of nuclear power plants in Korea. After dealing with it, it is expected that the revised regulatory framework for decommissioning could enhance the safety regime on the decommissioning of nuclear power plants in Korea in light of international standards. (authors)

  1. How State Regulatory Agencies Address Privatization: The Case of Wastewater Treatment.

    ERIC Educational Resources Information Center

    Heilman, John G.; Johnson, Gerald W.

    1991-01-01

    How state agencies have addressed privatization in a service setting (municipal wastewater treatment) is discussed. The implications for evaluations of many types of programs, particularly those of local service programs regulated by the states, are explored. Data from a national survey of state environmental regulatory agencies are highlighted.…

  2. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Scroggins, Sharon

    2008-01-01

    NASA's Agency-wide.resource for identifying and managing risks associated with changing environmental regulations Goals of the RRAC PC: 1) Proactively. detect, analyze and communicate environmental regulatory risks to NASA Programs and facilities; 2) Communicate with regulators and participate in the mitigation of such risks; and 3) Provide centralized support on emerging regulations to NASA HQ Environmental Management Division. When significant regulatory changes are identified, timely communication is essential. Communication of changing requirements to the regulatory stakeholders - NASA Programs and Facilities. Communication of potential issues to management and, when appropriate, back to the regulating agency.

  3. 77 FR 70847 - Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit No. 2, Request for Action AGENCY: Nuclear Regulatory Commission. ACTION: Request for...

  4. 78 FR 50458 - Entergy Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee Nuclear Power Station, Pilgrim Nuclear Power Station, Request for Action AGENCY: Nuclear Regulatory...

  5. Nuclear regulatory legislation, 104th Congress, Volume 1, No. 4

    SciTech Connect

    1997-12-01

    This document is the first of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Atomic Energy Act, Energy Reorganization Act, Low-Level Radioactive Waste Policy Amendments Act, and Nuclear Waste Policy Act. Other information included in this volume pertains to NRC user fees, NRC authorizations, the Inspector General Act, and the Administrative Procedure Act.

  6. Nuclear Regulatory Commission issuances, September 1995. Volume 42, Number 3

    SciTech Connect

    1995-09-01

    This book contains an issuance of the Atomic Safety and Licensing Board and a Director`s Decision, both of the US Nuclear Regulatory Commission. The issuance concerns the dismissal of a case by adopting a settlement reached by the Staff of the Nuclear Regulatory Commission and a Radiation Safety Officer of a hospital in which the safety officer pled guilty to deliberate misconduct. The Director`s Decision was to deny a petition to impose a fine on Tennessee Valley Authority concerning alleged harassment of the petitioner and to appoint an independent arbitration board to review all past complaints filed against TVA concerning the Watts Bar Nuclear Plant.

  7. Inspection and enforcement at the US Nuclear Regulatory Commission

    SciTech Connect

    Troskoski, W.M.

    1996-12-31

    Application of the U.S. Nuclear Regulatory Commission`s (NRC) inspection and enforcement programs related to nuclear criticality safety (NCS) are explored. The flowdown of regulatory requirements are traced from Title 10, Code of Federal Regulations, Part 70 (10 CFR 70), {open_quotes}Domestic Licensing of Special Nuclear Material,{close_quotes} through individual license requirements that include specific safety limits, management controls, and safety programs. The roles of documentation and auditability to demonstrate compliance with those license requirements are examined. NRC general expectations are briefly summarized.

  8. The role of regulatory agencies in multiple water use.

    PubMed

    Braga, B P F

    2003-01-01

    This paper presents the conceptual framework for regulating water use in cases where water is a public good. Public agencies with an independent directive board can successfully manage such a situation. Through a comprehensive system of water permits, charging and control it is possible to effectively manage water resources. Together with the conceptual framework a practical application is presented. The case of the National Water Agency of Brazil--ANA--shows that it is possible to implement modern water resources management concepts in less developed countries. The benefits of this institutional arrangement are demonstrated in the case of managing water conflicts among water users. Two situations are described: the semi-arid water allocation for agricultural use in the Jaraguaribe River Basin in Ceara State and the conflict between the hydropower and navigation sectors in the Parana River Basin. PMID:12731768

  9. 41 CFR 102-117.325 - May my agency appear on its own behalf before a transportation regulatory body proceeding?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... its own behalf before a transportation regulatory body proceeding? 102-117.325 Section 102-117.325... Regulatory Body Proceedings § 102-117.325 May my agency appear on its own behalf before a transportation regulatory body proceeding? Generally, no executive agency may appear on its own behalf in any...

  10. 41 CFR 102-117.325 - May my agency appear on its own behalf before a transportation regulatory body proceeding?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... its own behalf before a transportation regulatory body proceeding? 102-117.325 Section 102-117.325... Regulatory Body Proceedings § 102-117.325 May my agency appear on its own behalf before a transportation regulatory body proceeding? Generally, no executive agency may appear on its own behalf in any...

  11. 41 CFR 102-117.325 - May my agency appear on its own behalf before a transportation regulatory body proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... its own behalf before a transportation regulatory body proceeding? 102-117.325 Section 102-117.325... Regulatory Body Proceedings § 102-117.325 May my agency appear on its own behalf before a transportation regulatory body proceeding? Generally, no executive agency may appear on its own behalf in any...

  12. 41 CFR 102-117.325 - May my agency appear on its own behalf before a transportation regulatory body proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... its own behalf before a transportation regulatory body proceeding? 102-117.325 Section 102-117.325... Regulatory Body Proceedings § 102-117.325 May my agency appear on its own behalf before a transportation regulatory body proceeding? Generally, no executive agency may appear on its own behalf in any...

  13. 41 CFR 102-117.325 - May my agency appear on its own behalf before a transportation regulatory body proceeding?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... its own behalf before a transportation regulatory body proceeding? 102-117.325 Section 102-117.325... Regulatory Body Proceedings § 102-117.325 May my agency appear on its own behalf before a transportation regulatory body proceeding? Generally, no executive agency may appear on its own behalf in any...

  14. Regulatory climate of a nuclear project

    SciTech Connect

    Donlon, W.J.

    1984-11-22

    The president of Niagara Mohawk Power Corporation reviews the regulatory and other experiences of a consortium of New York utilities which have been engaged for the past 10 years in the construction of the Nine Mile Unit Two project on Lake Ontario near Oswego, NY. As the lead owner and operator of the plant, Niagara Mohawk's Donlow describes significant developments bearing upon the project and its ultimate financial and operating feasibility.

  15. U.S. Nuclear Regulatory Commission natural analogue research program

    SciTech Connect

    Kovach, L.A.; Ott, W.R.

    1995-09-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process.

  16. U.S. Nuclear Regulatory Commission

    MedlinePlus

    ... Copies of Documents FOIA & Privacy Act Photos & Video Records Management Withholding of Sensitive Information FAQ Index Electronic Hearing ... Lessons Learned Seabrook Concrete Degradation NRC Safety Culture Policy Statement ... Spotlight Archive » News & Speeches September 12, 2016 Nuclear ...

  17. 75 FR 41241 - Draft Regulatory Guide; Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... COMMISSION Draft Regulatory Guide; Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Issuance, availability of Draft Regulatory Guide (DG)-1234. ADDRESSES: You may submit comments by any one... and licenses. The draft regulatory guide, entitled, ``Water Sources for Long-Term...

  18. 76 FR 60557 - Closure of the U.S. Nuclear Regulatory Commission's Two White Flint North Building Entrance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... COMMISSION Closure of the U.S. Nuclear Regulatory Commission's Two White Flint North Building Entrance AGENCY...) building entrance lobby. Only NRC badged employees and contractors shall be permitted to use the Two White..., Rockville, MD 20852-2738. Two White Flint North is located at 11545 Rockville Pike, Rockville, MD...

  19. Occupational exposure assessment: Practices in Malaysian nuclear agency

    NASA Astrophysics Data System (ADS)

    Sarowi, S. Muhd; Ramli, S. A.; Kontol, K. Mohamad; Rahman, N. A. H. Abd.

    2016-01-01

    Malaysian Nuclear Agency (Nuclear Malaysia) is the leading agency in introducing and promoting the application of nuclear science technology in Malaysia. The agency provides major nuclear facilities purposely for research and commercialisation such as reactor, irradiation plants and radioisotope production laboratory. When dealing with ionizing radiation, there is an obligatory requirement to monitor and assess the radiation exposure to the workers. The personal dose of radiation workers were monitored monthly by assessing their Thermoluminescence Dosimeter (TLD) dose reading. This paper will discuss the current practice in managing, assessing, record keeping and reporting of the occupational exposure in Nuclear Malaysia including the Health Physic Group roles and challenges. The statistics on occupational radiation exposure of monitored workers working in different fields in Nuclear Malaysia from 2011 - 2013 will also be presented. The results show that the null hypothesis (H₀) was accepted which the means of every populations are all equal or not differ significantly. This hypothesis states that the dose exposure received by the radiation workers in Nuclear Malaysia is similar and there were no significant changes from 2011 to 2013. The radiation monitoring programme correlate with the requirement of our national law, the Atomic Energy Licensing Act 1984 (Act 304).

  20. US Nuclear Regulatory Commission organization charts and functional statements

    SciTech Connect

    1997-11-01

    This document contains organization charts for the U.S. Nuclear Regulatory Commission (NRC) and for the five offices of the NRC. Function statements are provided delineating the major responsibilities and operations of each office. Organization and function are provided to the branch level. The head of each office, division, and branch is also listed.

  1. Reformation of Regulatory Technical Standards for Nuclear Power Generation Equipments in Japan

    SciTech Connect

    Mikio Kurihara; Masahiro Aoki; Yu Maruyama; Kiyosi Takasaka; Shigetada Nakajo; Zenichi Ogiso; Yukinori Goto

    2006-07-01

    Comprehensive reformation of the regulatory system has been introduced in Japan in order to apply recent technical progress in a timely manner. 'The Technical Standards for Nuclear Power Generation Equipments', known as the Ordinance No.622) of the Ministry of International Trade and Industry, which is used for detailed design, construction and operating stage of Nuclear Power Plants, was being modified to performance specifications with the consensus codes and standards being used as prescriptive specifications, in order to facilitate prompt review of the Ordinance with response to technological innovation. The activities on modification were performed by the Nuclear and Industrial Safety Agency (NISA), the regulatory body in Japan, with support of the Japan Nuclear Energy Safety Organization (JNES), a technical support organization. The revised Ordinance No.62 was issued on July 1, 2005 and is enforced from January 1 2006. During the period from the issuance to the enforcement, JNES carried out to prepare enforceable regulatory guide which complies with each provisions of the Ordinance No.62, and also made technical assessment to endorse the applicability of consensus codes and standards, in response to NISA's request. Some consensus codes and standards were re-assessed since they were already used in regulatory review of the construction plan submitted by licensee. Other consensus codes and standards were newly assessed for endorsement. In case that proper consensus code or standards were not prepared, details of regulatory requirements were described in the regulatory guide as immediate measures. At the same time, appropriate standards developing bodies were requested to prepare those consensus code or standards. Supplementary note which provides background information on the modification, applicable examples etc. was prepared for convenience to the users of the Ordinance No. 62. This paper shows the activities on modification and the results, following the

  2. Nuclear Regulatory legislation: 103d Congress. Volume 1, No. 3

    SciTech Connect

    1995-08-01

    This document is a compilation of nuclear regulatory legislation and other relevant material through the 103d Congress, 2d Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include the Atomic Energy Act of 1954, as amended; Energy Reorganization Act of 1974, as amended, Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statutes and treaties on export licensing, nuclear non-proliferation, and environmental protection.

  3. Nuclear regulatory legislation: 102d Congress. Volume 1, No. 2

    SciTech Connect

    Not Available

    1993-10-01

    This document is a compilation of nuclear regulatory legislation and other relevant material through the 102d Congress, 2d Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include: The Atomic Energy Act of 1954, as amended; Energy Reorganization Act of 1974, as amended, Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statutes and treaties on export licensing, nuclear non-proliferation, and environmental protection.

  4. Nuclear Regulatory legislation: 103d Congress. Volume 2, No. 3

    SciTech Connect

    1995-08-01

    This document is a compilation of nuclear regulatory legislation and other relevant material through the 103d Congress, 2d Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include the Atomic Energy Act of 1954, as amended; Energy Reorganization Act of 1974, as amended, Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statutes and treaties on export licensing, nuclear non-proliferation, and environmental protection.

  5. Nuclear regulatory legislation, 102d Congress. Volume 2, No. 2

    SciTech Connect

    Not Available

    1993-10-01

    This document is a compilation of nuclear regulatory legislation and other relevant material through the 102d Congress, 2d Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include The Atomic Energy Act of 1954, as amended; Energy Reorganization Act of 1974, as amended, Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statutes and treaties on export licensing, nuclear non-proliferation, and environmental protection.

  6. 10 CFR 70.11 - Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory Commission contracts. 70.11 Section 70.11 Energy NUCLEAR... using special nuclear material under certain Department of Energy and Nuclear Regulatory...

  7. 10 CFR 70.11 - Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory Commission contracts. 70.11 Section 70.11 Energy NUCLEAR... using special nuclear material under certain Department of Energy and Nuclear Regulatory...

  8. 10 CFR 70.11 - Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory Commission contracts. 70.11 Section 70.11 Energy NUCLEAR... using special nuclear material under certain Department of Energy and Nuclear Regulatory...

  9. Nuclear regulatory legislation, 104th Congress. Volume 2, No. 4

    SciTech Connect

    1997-12-01

    This document is the second of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Paperwork Reduction Act, various acts pertaining to low-level radioactive waste, the Clean Air Act, the Federal Water Pollution Control Act, the National Environmental Policy Act, the Hazardous Materials Transportation Act, the West Valley Demonstration Project Act, Nuclear Non-Proliferation and Export Licensing Statutes, and selected treaties, agreements, and executive orders. Other information provided pertains to Commissioner tenure, NRC appropriations, the Chief Financial Officers Act, information technology management reform, and Federal civil penalties.

  10. Steam Generator tube integrity -- US Nuclear Regulatory Commission perspective

    SciTech Connect

    Murphy, E.L.; Sullivan, E.J.

    1997-02-01

    In the US, the current regulatory framework was developed in the 1970s when general wall thinning was the dominant degradation mechanism; and, as a result of changes in the forms of degradation being observed and improvements in inspection and tube repair technology, the regulatory framework needs to be updated. Operating experience indicates that the current U.S. requirements should be more stringent in some areas, while in other areas they are overly conservative. To date, this situation has been dealt with on a plant-specific basis in the US. However, the NRC staff is now developing a proposed steam generator rule as a generic framework for ensuring that the steam generator tubes are capable of performing their intended safety functions. This paper discusses the current U.S. regulatory framework for assuring steam generator (SG) tube integrity, the need to update this regulatory framework, the objectives of the new proposed rule, the US Nuclear Regulatory Commission (NRC) regulatory guide (RG) that will accompany the rule, how risk considerations affect the development of the new rule, and some outstanding issues relating to the rule that the NRC is still dealing with.

  11. 76 FR 2725 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Issuance, Availability of Draft Regulatory Guide (DG)-1245. FOR FURTHER INFORMATION CONTACT: Mark P. Orr, U.S. Nuclear Regulatory Commission,...

  12. 78 FR 55117 - Ultimate Heat Sink for Nuclear Power Plants; Draft Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ...The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment draft regulatory guide (DG), DG-1275, ``Ultimate Heat Sink for Nuclear Power Plants.'' This regulatory guide (RG) describes methods and procedures acceptable to the NRC staff that nuclear power plant facility licensees and applicants may use to implement general design criteria (GDC) that are applicable to the ultimate......

  13. 10 CFR Appendix D to Part 20 - United States Nuclear Regulatory Commission Regional Offices

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false United States Nuclear Regulatory Commission Regional Offices D Appendix D to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. D Appendix D to Part 20—United States Nuclear Regulatory Commission Regional Offices Address Telephone (24 hour) E-Mail...

  14. 10 CFR Appendix D to Part 20 - United States Nuclear Regulatory Commission Regional Offices

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false United States Nuclear Regulatory Commission Regional Offices D Appendix D to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. D Appendix D to Part 20—United States Nuclear Regulatory Commission Regional...

  15. 10 CFR Appendix D to Part 20 - United States Nuclear Regulatory Commission Regional Offices

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false United States Nuclear Regulatory Commission Regional Offices D Appendix D to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. D Appendix D to Part 20—United States Nuclear Regulatory Commission Regional...

  16. 10 CFR Appendix D to Part 20 - United States Nuclear Regulatory Commission Regional Offices

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false United States Nuclear Regulatory Commission Regional Offices D Appendix D to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. D Appendix D to Part 20—United States Nuclear Regulatory Commission Regional...

  17. 10 CFR Appendix D to Part 20 - United States Nuclear Regulatory Commission Regional Offices

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false United States Nuclear Regulatory Commission Regional Offices D Appendix D to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. D Appendix D to Part 20—United States Nuclear Regulatory Commission Regional...

  18. Progress in Norwegian-Russian Regulatory Cooperation in Management of the Nuclear Legacy

    SciTech Connect

    Sneve, M.K.; Shandala, N.K.; Smith, G.M.

    2008-07-01

    The Norwegian Radiation Protection Authority (NRPA) and the Federal Medical-Biological Agency (FMBA) of the Russian Federation have a collaboration programme which forms part of the Norwegian government's Plan of Action to improve radiation and nuclear safety in northwest Russia. The background to the NRPA-FMBA collaboration programme has been described in previous WM presentations. This paper presents the substantial progress made within that programme, describes ongoing progress within specific projects and sets out the value arising from wider involvement in the programme of other organisations such as NATO and the technical support derived from other national agencies such as the IAEA, and regulatory authorities from the USA, the UK and France. The main activities of the cooperation projects are concerned with the management of the nuclear legacy in northwest Russia, in particular the remediation of facilities, and related spent fuel and radioactive waste management, at the former Shore Technical Bases at Andreeva Bay and Gremikha Village. New regulatory guidance documents have been developed, necessary because of the special abnormal situation at these sites, now designated as Sites of Temporary Storage (STS), but also because of the transition from military to civilian regulatory supervision and the evolving regulatory system in the Russian Federation. The work has involved major technical inputs from the Russian Federation Institute of Biophysics, as well as review and advice on international recommendations and good practice in other countries provided by other technical support organisations. Projects on-going in 2007 are described which involve regulatory guidance on very Low-Level Waste management, specifically for the licensing and operation of new VLLW disposal facilities; optimisation of operational radiation protection, particularly in areas of high ambient radiation dose rate as are found in some parts of the STSs; determination of factors which can

  19. 10 CFR 70.11 - Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory Commission contracts. 70.11 Section 70.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DOMESTIC LICENSING OF SPECIAL NUCLEAR MATERIAL Exemptions § 70.11...

  20. 10 CFR 70.11 - Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Persons using special nuclear material under certain Department of Energy and Nuclear Regulatory Commission contracts. 70.11 Section 70.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DOMESTIC LICENSING OF SPECIAL NUCLEAR MATERIAL Exemptions § 70.11...

  1. Jaczko to resign as chair of Nuclear Regulatory Commission

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-05-01

    Gregory Jaczko, chair of the U.S. Nuclear Regulatory Commission (NRC), announced on 21 May that he will resign once his successor is appointed. His resignation will end a stormy 3-year chairmanship during which he was accused of bullying NRC staff, lying to Congress, and being too close to the political process. Jaczko formerly served as science advisor to Sen. Harry Reid (D-Nev.). As NRC chair, Jaczko halted the commission's license application review for storing nuclear waste at Nevada's Yucca Mountain. In addition, during his NRC tenure the commission focused on identifying and implementing lessons from Japan's Fukushima Daiichi reactors damaged by the 2011 tsunami.

  2. The quality and characteristics of clinical drug study notifications reviewed by the regulatory agency in Finland.

    PubMed

    Keinonen, Tuija; Nieminen, Sakari; Saareks, Virpi; Miettinen, Pirkko; Saano, Veijo; Ylitalo, Pauli

    2002-02-01

    The aim of our study was to investigate the validity of clinical drug study notifications reviewed by the regulatory agency in Finland during the 1990s. (In practice, the notification is equivalent to tacit authorization, which the agency has full powers to revoke before it takes effect.) All clinical drug studies reviewed by the agency during the years 1992, 1994, 1996, and 1998 were studied retrospectively. The main measurements used were the number of studies with no objection to start; the number and type of questions raised; the profile, phase, and type of study; and the study design. Additionally, the studies approved by two ethics committees of university hospitals during the same years were cross-checked to see whether the agency was notified of them in accordance with the national regulations. In total, 1174 study notifications were reviewed. Most studies were international (52%), phase III (46%), placebo-controlled with/without active control (35%) investigations of new chemical entities (38%) and were carried out in university hospitals (63%). The regulatory agency had no objections or questions regarding 55% of the notifications; 37% of the studies were permitted to begin after a clarification; 5% had to be clarified a second time; and 3% were rejected. Most questions dealt with subject information. Out of the 1140 permitted studies, 8% were later canceled or prematurely terminated as reported by the applicant. Altogether 71% of the studies that had been reviewed and approved by the ethics committees were reported to the authorities before commencement. Study completions were rarely reported. Most of the clinical drug studies planned in Finland are large international studies to investigate new chemical entities. More than half of the notifications are valid according to the regulatory authorities. Not all studies, nor the majority of study completions, are reported to the authority, though according to the regulations they should be so reported. The

  3. Progress toward regulatory acceptance of risk-informed inspection programs for nuclear power plants

    NASA Astrophysics Data System (ADS)

    Hedden, Owen F.; Cowfer, C. David

    1996-11-01

    This paper will describe work within the American Society of Mechanical Engineers committee responsible for rules for inservice inspection of nuclear power plants. Work is progressing with the objective of producing proposals for risk-informed inspection programs that will be incorporated by the US Nuclear Regulatory Commission into the Federal Regulations Governing the construction and inservice inspection of al domestic commercial power plants. The paper will describe in detail the two primary proposals now under development and review. Both are directed toward enhancing safety while reducing the expense of periodic examination of piping welds. The first proposal provides a sound technical basis for reducing the number of Class 1 piping weld examinations as much as 60 percent while improving or maintaining equivalent safety. This is accomplished by using risk-informed techniques to re-establish the most important areas to examine. The second is a broader approach addressing all piping systems considered to be important under risk-informed assessment techniques. Both proposals are based on recent insights into risk analysis techniques developed within the pressure vessel industry, and both require evaluation of theoretical analysis and inputs of practical experience related to a wide variety of detrimental conditions. These proposals are being supported by pilot programs in a number of operating nuclear power plants. The authors will also attempt to explain the institutional constraints inherent in the process of obtaining regulatory recognition of proposals developed cooperatively by industry and the regulatory agency.

  4. State of Nevada, Agency for Nuclear Projects/Nuclear Waste Project Office narrative report, January 1992

    SciTech Connect

    1992-12-31

    The Agency for Nuclear Projects/Nuclear Waste Project Office (NWPO) is the State of Nevada agency designated by State law to monitor and oversee US Department of Energy (DOE) activities relative to the possible siting, construction, operation and closure of a high-level nuclear waste repository at Yucca Mountain and to carry out the State of Nevada`s responsibilities under the Nuclear Waste Policy Act of 1982. During the reporting period the NWPO continued to work toward the five objectives designed to implement the Agency`s oversight responsibilities: (1) Assure that the health and safety of Nevada`s citizens are adequately protected with regard to any federal high-level radioactive waste program within the State; (2) Take the responsibilities and perform the duties of the State of Nevada as described in the Nuclear Waste Policy Act of 1982 (Public Law 97-425) and the Nuclear Waste Policy Amendments Act of 1987; (3) Advise the Governor, the State Commission on Nuclear Projects and the Nevada State Legislature on matters concerning the potential disposal of high-level radioactive waste in the State; (4) Work closely and consult with affected local governments and State agencies; (5) Monitor and evaluate federal planning and activities regarding high-level radioactive waste disposal. Plan and conduct independent State studies regarding the proposed repository.

  5. 78 FR 39018 - Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit Nos. 2 and 3 AGENCY: Nuclear Regulatory Commission. ACTION: Supplement to Final Supplement 38 to the Generic...

  6. NASA's Agency-wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Duda, Kristen; Scroggins. Sharon

    2008-01-01

    NASA's mission is to pioneer the future in space exploration, scientific discovery, and aeronautics research. To help enable existing and future programs to pursue this mission, NASA has established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) to proactively identify, analyze, and communicate environmental regulatory risks to the NASA community. The RRAC PC is chartered to evaluate the risks posed to NASA Programs and facilities by environmentally related drivers. The RRAC PC focuses on emerging environmental regulations, as well as risks related to operational changes that can trigger existing environmental requirements. Changing regulations have the potential to directly affect program activities. For example, regulatory changes can restrict certain activities or operations by mandating changes in how operations may be done or limiting where or how certain operations can take place. Regulatory changes also can directly affect the ability to use certain materials by mandating a production phase-out or restricting usage aPi'iications of certain materials. Such changes can result in NASA undertaking material replacement efforts. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented several strategies for proactively managing regulatory change to minimize potential adverse impacts to NASA Programs and facilities. This presentation highlights the lessons learned through establishing the RRAC PC, the process by which the RRAC PC monitors and distributes information about emerging regulatory requirements, and the cross-Agency

  7. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Duda, Kristen; Scroggins, Sharon

    2008-01-01

    NASA's mission is to pioneer the future in space exploration, scientific discovery, and aeronautics research. To help enable existing and future programs to pursue this mission, NASA has established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) to proactively identify, analyze, and communicate environmental regulatory risks to the NASA community. The RRAC PC is chartered to evaluate the risks posed to NASA Programs and facilities by environmentally related drivers. The RRAC PC focuses on emerging environmental regulations, as well as risks related to operational changes that can trigger existing environmental requirements. Changing regulations have the potential to directly affect program activities. For example, regulatory changes can restrict certain activities or operations by mandating changes in how operations may be done or limiting where or how certain operations can take place. Regulatory changes also can directly affect the ability to use certain materials by mandating a production phase-out or restricting usage applications of certain materials. Such changes can result in NASA undertaking material replacement efforts. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented several strategies for proactively managing regulatory change to minimize potential adverse impacts to NASA Programs and facilities. This presentation highlights the lessons learned through establishing the RRAC PC, the process by which the RRAC PC monitors and distributes information about emerging regulatory requirements, and the cross-Agency

  8. Improved cost-benefit techniques in the US Nuclear Regulatory Commission

    SciTech Connect

    Cronin, F.J.; Nesse, R.J.; Vaeth, M.; Wusterbarth, A.R.; Currie, J.W.

    1983-06-01

    The major objective of this report is to help the US Nuclear Regulatory Commission (NRC) in its regulatory mission, particularly with respect to improving the use of cost-benefit analysis and the economic evaluation of resources within the NRC. The objectives of this effort are: (1) to identify current and future NRC requirements (e.g., licensing) for valuing nonmarket goods; (2) to identify, highlight, and present the relevant efforts of selected federal agencies, some with over two decades of experience in valuing nonmarket goods, in this area; and (3) to review methods for valuing nonmarket impacts and to provide estimats of their magnitudes. Recently proposed legislation may result in a requirement for not only more sophisticated valuation analyses, but more extensive applications of these techniques to issues of concern to the NRC. This paper is intended to provide the NRC with information to more efficiently meet such requirements.

  9. Nuclear Regulatory Commission issuances, May 1993. Volume 37, No. 5

    SciTech Connect

    Not Available

    1993-05-01

    This report contains the issuances received during the specified period (May 1993) from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not deemed a part of these opinions or have any independent legal significance. Contents of this document include an Issuance of the Nuclear Regulatory Commission with respect to the Sacramento Municipal Utility District and Issuances of Directors` Decisions concerning the Interstate Nuclear Service Corporation; Niagara Mohawk Power Corporation; and Texas Utilities Electric Company, et al. and All Nuclear Power Plants with Thermo-Lag Fire Barriers.

  10. The nuclear energy outlook--a new book from the OECD nuclear energy agency.

    PubMed

    Yoshimura, Uichiro

    2011-01-01

    This paper summarizes the key points of a report titled Nuclear Energy Outlook, published in 2008 by the Nuclear Energy Agency of the Organization for Economic Cooperation and Development, which has 30 member nations. The report discusses the commitment of many nations to increase nuclear power generating capacity and the potential rate of building new electricity-generating nuclear plants by 2030 to 2050. The resulting decrease in carbon dioxide emissions from fossil fuel combustion resulting from an increase in nuclear power sources is described. Other topics that are discussed include the need to develop non-proliferative nuclear fuels, the importance of developing geological disposal facilities or reprocessing capabilities for spent nuclear fuel and high-level radioactive waste materials, and the requirements for a larger nuclear workforce and greater cost competitiveness for nuclear power generation. PMID:21399406

  11. 75 FR 20645 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-4018. FOR FURTHER INFORMATION CONTACT... Regulatory Commission (NRC) is issuing for public comment a draft guide in the agency's ``Regulatory...

  12. 75 FR 36715 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide, RG 1.62. FOR FURTHER INFORMATION CONTACT: Karl J... Regulatory Commission (NRC or Commission) is issuing a revision of a guide in the agency's ``Regulatory...

  13. Nuclear Regulatory Commission issuances: Opinions and decisions of the Nuclear Regulatory Commission with selected orders, July 1--December 31, 1996. Volume 44, Pages 1--432

    SciTech Connect

    1997-10-01

    The hardbound edition of the Nuclear Regulatory Commission Issuances is a final compilation of the monthly issuances. It includes all of the legal precedents for the agency within a six-month period. Any opinions, decisions, denials, memoranda and orders of the Commission inadvertently omitted from the monthly softbounds and any corrections submitted by the NRC legal staff to the printed softbound issuances are contained in the hardbound edition. Cross references in the text and indexes are to the NRCI page numbers which are the same as the page numbers in this publication. Issuances are referred to as follows: Commission--CLI, Atomic Safety and Licensing Boards--LBP, Administrative Law Judges--ALJ, Directors` Decisions--DD, and Decisions on Petitions for Rulemaking--DPRM.

  14. Nuclear Regulatory Commission issuances. Opinions and decisions of the Nuclear Regulatory Commission with selected orders, July 1, 1994--December 31, 1994. Volume 40, Pages 1--387

    SciTech Connect

    1994-12-31

    The hardbound edition of the Nuclear Regulatory Commission Issuances is a final compilation of the monthly issuances. It includes all of the legal precedents for the agency within a six-month period. Any opinions, decisions, denials, memoranda and orders of the Commission inadvertently omitted from the monthly softbounds and any corrections submitted by the NRC legal staff to the printed softbound issuances are contained in the hardbound edition. Cross references in the text and indexes are to the NRCI page numbers which are the same as the page numbers in this publication. This book covers the following: issuances of the NRC; issuances of the Atomic Safety and Licensing Boards; and issuances of Directors` decisions.

  15. Organizational behavior of regulatory agencies: a case study of the Bureau of Consumer Services in the Pennsylvania Public Utility Commission

    SciTech Connect

    Silver, J.H.

    1981-01-01

    Regulatory agencies operate in a complex field of organizations and interest groups. The variety of behaviors that occur in the regulatory field are not satisfactorily explained by current interpretative frameworks. Regulatory agencies are at once criticized and praised. They flourish as organizational entities, yet they exhibit behavior that is often inexplicable. Notions like clientele capture, the politics of regulation, exchange theory, and institutionalized organizations do not singly explain the vagaries of regulatory behavior. A merger of these viewpoints, however, provides a foundation for a comprehensive interpretative framework. A bureau of consumer services within a state public utility commission is viewed as an institutionalized organization. From this perspective, a variety of ritual behaviors, based upon symbolic and tangible interorganizational exchanges are observed and characterized. The outcome of these exchanges is the establishment of the Bureau of Consumer Services as a legitimate regulatory agent with significant impact upon the formulation of regulatory policy in the formal proceedings of the Pennsylvania Public Utility Commission.

  16. Nuclear Forensic Science: Analysis of Nuclear Material Out of Regulatory Control

    NASA Astrophysics Data System (ADS)

    Kristo, Michael J.; Gaffney, Amy M.; Marks, Naomi; Knight, Kim; Cassata, William S.; Hutcheon, Ian D.

    2016-06-01

    Nuclear forensic science seeks to identify the origin of nuclear materials found outside regulatory control. It is increasingly recognized as an integral part of a robust nuclear security program. This review highlights areas of active, evolving research in nuclear forensics, with a focus on analytical techniques commonly employed in Earth and planetary sciences. Applications of nuclear forensics to uranium ore concentrates (UOCs) are discussed first. UOCs have become an attractive target for nuclear forensic researchers because of the richness in impurities compared to materials produced later in the fuel cycle. The development of chronometric methods for age dating nuclear materials is then discussed, with an emphasis on improvements in accuracy that have been gained from measurements of multiple radioisotopic systems. Finally, papers that report on casework are reviewed, to provide a window into current scientific practice.

  17. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government...

  18. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government...

  19. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government...

  20. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government...

  1. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government...

  2. Nuclear medicine survey recommendations for a changing regulatory environment.

    PubMed

    Vernig, P G; Schumacher, T A

    2001-11-01

    The revision of 10 CFR 35 approved on 23 September 2000 and due for implementation in 2001, reduces the number of required radiation and contamination surveys to one ambient radiation survey each day when an administration requiring a written directive is used. This paper compares the current requirements in 10 CFR 35; the single, remaining, specific requirement in the revised part 35; the Nuclear Regulatory Commission's guidance in the proposed NUREG SR1556 and the general requirement for surveys to demonstrate compliance with 10 CFR 20. We also make recommendations on what periodic surveys are prudent. PMID:11669196

  3. Nuclear Regulatory Commission Issuances: February 1995. Volume 41, Number 2

    SciTech Connect

    1995-02-01

    This book contains an issuance of the Nuclear Regulatory Commission and a Director`s Decision. The issuance concerns consideration by the Commission of appeals from both the Initial Decision and a Reconsideration Order issued by the Presiding Officer involving two materials license amendment applications filed by the University of Missouri. The Director`s Decision from the Office of Enforcement denies petitions filed by Northeast Utilities employees requesting that accelerated enforcement action be taken against Northeast Utilities for activities concerned with NU`s fitness-for-duty program.

  4. Regulatory ratchet clicks, nukes are abandoned, but Nuclear Regulatory Commission envisions brighter future

    SciTech Connect

    Utroska, D.

    1982-04-01

    Nuclear power plant construction regulations issued after the Three Mile Island accident have affected 11 plants, only five of which remain committed to construction although all are in jeopardy. A review of the cancellations identifies prohibitive costs and financing problems due to the new regulations as the deciding factor. There are three classes of new rules: a probabilistic risk assessment within two years of receiving a construction permit, stronger containment structures, and more-sophisticated hydrogen-control features. The Nuclear Regulatory Commission (NRC) now appears to be joining the administration's goal of streamlining regulations, particularly in the areas of backfitting and final-design-approval rules based on standardization. Some observers are critical of the standardization approach because of plant complexity, but they foresee efforts toward simplification as manufacturers plan designs for reference approval. (DCK)

  5. Hazardous waste management system--Environmental Protection Agency. Notice of regulatory reform actions; request for comments.

    PubMed

    1982-12-13

    In response to Executive Order 12291 and the President's Task Force on Regulatory Relief, the Environmental Protection Agency is reviewing and reassessing the hazardous waste regulations developed under the Resource Conservation and Recovery Act (RCRA). A variety of activities are underway that will simplify procedures and reduce paperwork, modify existing regulations to make them more workable and cost effective, and control new wastes and new processes. The purpose of this notice is to inform the public of these activities and invite comments on the general approaches being taken. PMID:10259796

  6. 76 FR 16017 - Withdrawal of Regulatory Guide 8.5

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... COMMISSION Withdrawal of Regulatory Guide 8.5 AGENCY: Nuclear Regulatory Commission. ACTION: Withdrawal of Regulatory Guide 8.5, ``Criticality and Other Interior Evacuation Signals.'' FOR FURTHER INFORMATION CONTACT... The U.S. Nuclear Regulatory Commission (NRC) is withdrawing Regulatory Guide 8.5, ``Criticality...

  7. 76 FR 6086 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... COMMISSION 10 CFR Part 73 RIN 3150-AI49 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Availability of Draft Regulatory Guide. SUMMARY: The U.S. Nuclear Regulatory Commission (Commission or NRC) is issuing for public comment Draft Regulatory Guide,...

  8. 76 FR 27924 - Draft Regulatory Guide, Guidance for ITAAC Closure

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... COMMISSION 10 CFR Parts 2 and 52 RIN 3150-AI77 Draft Regulatory Guide, Guidance for ITAAC Closure AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment Draft Regulatory Guide...

  9. 76 FR 34007 - Draft Regulatory Basis for a Potential Rulemaking on Spent Nuclear Fuel Reprocessing Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ...: NUREG-1909, a white paper authored by the Advisory Committee on Nuclear Waste and Materials, titled... waste through developing more sophisticated reprocessing technologies. During the Bush Administration... regulatory basis for licensing commercial reprocessing facilities: (1) Regulatory framework, (2)...

  10. 78 FR 55118 - Seismic Instrumentation for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Seismic Instrumentation for Nuclear Power Plants AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan-draft section revision; request for comment. SUMMARY: The U.S. Nuclear...

  11. 75 FR 11574 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of draft regulatory guide, DG-1242, ``Service Level I, II, and III Protective Coatings Applied To Nuclear Power...

  12. 75 FR 1830 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide (RG) 5.71, ``Cyber Security Programs for Nuclear Facilities.'' FOR FURTHER INFORMATION...

  13. 75 FR 2894 - Withdrawal of Regulatory Guide 1.148

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Withdrawal of Regulatory Guide 1.148 AGENCY: Nuclear Regulatory Commission. ACTION: Withdrawal of Regulatory Guide 1.148, ``Functional Specification for Active Valve Assemblies in Systems Important to Safety in Nuclear Power Plants.'' FOR...

  14. 75 FR 43207 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.141, Revision 1. FOR FURTHER INFORMATION CONTACT: Robert G. Carpenter, U.S. Nuclear...

  15. 75 FR 35508 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1249, ``Criteria for Use of Computers in Safety Systems of Nuclear Power Plants.''...

  16. 77 FR 16278 - License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear Operations, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent...

  17. Nuclear Regulatory Commission issuances, April 1995. Volume 41, Number 4

    SciTech Connect

    1995-04-01

    This book contains issuances of the Nuclear Regulatory Commission and of the Atomic Safety and Licensing Boards, and an issuance of the Director`s decision. The issuances concern a petition filed by Dr. James E Bauer seeking interlocutory Commission review of the Atomic Safety and Licensing Board`s order imposing several restrictions on Dr. Bauer; a denial of an Interveners` Petition for Review addressing the application of Babcock and Wilcox for a renewal of its Special Nuclear Materials License; granting a motion for a protective order, by Sequoyah Fuel Corporation and General Atomics, limiting the use of the protected information to those individuals participating in the litigation and for the purposes of the litigation only; granting a Petitioner`s petition for leave to intervene and request for a hearing concerning Georgia Institute of Technology (Georgia Tech Research Reactor) renewal of a facility license; and a denial of a petition filed by Mr. Ted Dougherty requesting a shutdown of the San Onofre Nuclear Generating Station based on concerns regarding the vulnerability of the plant to earthquakes and defensibility of the plant to a terrorist threat.

  18. Access to regulatory data from the European Medicines Agency: the times they are a-changing.

    PubMed

    Wieseler, Beate; McGauran, Natalie; Kerekes, Michaela F; Kaiser, Thomas

    2012-01-01

    Systematic reviewers are increasingly trying to obtain regulatory clinical study reports (CSRs) to correct for publication bias. For instance, our organization, the Institute for Quality and Efficiency in Health Care, routinely asks drug manufacturers to provide full CSRs of studies considered in health technology assessments. However, since cooperation is voluntary, CSRs are available only for a subset of studies analysed. In the case of the inhaled insulin Exubera, the manufacturer refused to cooperate and in 2007 we asked the European Medicines Agency (EMA) to provide the relevant CSRs, but EMA denied access. Other researchers have reported similar experiences.In 2010 EMA introduced a new policy on access to regulatory documents, including CSRs, and has also undertaken further steps. The new policy has already borne fruit: in 2011, by providing additional sections of relevant CSRs, EMA made an important contribution to a review of oseltamivir (Tamiflu).Unfortunately, speedy implementation of the new policy may be endangered. We define a CSR following the International Conference on Harmonisation (ICH) E3 guideline. Although this guideline requires individual patient data listings, it does not necessarily require that these listings be made available in a computer-readable format, as proposed by some regulators from EMA and other agencies. However, access to raw data in a computer-readable format poses additional problems; merging this issue with that of access to CSRs could hamper the relatively simple implementation of the EMA policy. Moreover, EMA plans to release CSRs only on request; we suggest making these documents routinely available on the EMA website.Public access to regulatory data also carries potential risks. In our view, the issue of patient confidentiality has been largely resolved by current European legislation. The risk of other problems, such as conflicts of interest (CoIs) of independent researchers or quality issues can be reduced by

  19. Institutional Radiation Safety Committee--Nuclear Regulatory Commission. Final rule.

    PubMed

    1982-09-13

    The Nuclear Regulatory Commission (NRC) is amending its regulations regarding hospitals licensed to use radioactive byproduct material for human applications. Currently, such a license requires that the hospital have a Medical Isotopes Committee to review clinical aspects of the use of radioactive materials within the hospital. The amendment requires instead a Radiation Safety Committee with a simplified membership that will focus on the radiation safety of workers and the general public. The rule change acknowledges the Food and Drug Administration's role in regulating the safety and effectiveness of radioactive drugs with respect to the patient. The membership of the new Radiation Safety Committee will include the hospital management and the nursing staff in decisions affecting radiation safety at the hospital and will be easier for smaller hospitals to recruit. PMID:10259789

  20. 76 FR 18262 - Notice of issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... COMMISSION Notice of issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.44, Revision 1, ``Control of the Processing and Use of... Commission (NRC) is issuing a revision to an existing guide in the agency's ``Regulatory Guide'' series....

  1. 75 FR 9627 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 1.40. FOR FURTHER INFORMATION CONTACT: Thomas Koshy, U.S... guide in the agency's ``Regulatory Guide'' series. This series was developed to describe and...

  2. 75 FR 16516 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-2004, ``Emergency Planning for Research... draft guide in the agency's ``Regulatory Guide'' series. This series was developed to describe and...

  3. 76 FR 14108 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.34, Revision 1, ``Control of Electroslag Weld Properties... an existing guide in the agency's ``Regulatory Guide'' series. This series was developed to...

  4. 76 FR 38213 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Revision 2 of Regulatory Guide 1.107, ``Qualification for Cement Grouting for... or Commission) is issuing a revision to an existing guide in the agency's ``Regulatory Guide''...

  5. 76 FR 28102 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 1.177, Revision 1, ``An Approach for Plant-Specific, Risk... issuing a revision to an existing guide in the agency's ``Regulatory Guide'' series. This series...

  6. 75 FR 9626 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 1.47, Revision 1, ``Bypassed and Inoperable Status Indication... an existing guide in the agency's ``Regulatory Guide'' series. This series was developed to...

  7. Comparison of ISO 9000 and recent software life cycle standards to nuclear regulatory review guidance

    SciTech Connect

    Preckshot, G.G.; Scott, J.A.

    1998-01-20

    Lawrence Livermore National Laboratory is assisting the Nuclear Regulatory Commission with the assessment of certain quality and software life cycle standards to determine whether additional guidance for the U.S. nuclear regulatory context should be derived from the standards. This report describes the nature of the standards and compares the guidance of the standards to that of the recently updated Standard Review Plan.

  8. Leak testing United States Nuclear Regulatory Commission type b packaging

    SciTech Connect

    Lacy, K.A.

    1995-12-31

    The Waste Isolation Pilot Plant (WTPP) is a one of its kind research and development facility operated by the Department of Energy, Carlsbad Area Office. Located in southeastern New Mexico, the WTPP is designed to demonstrate the safe, permanent disposal of transuranic (TRU) radioactive nuclear waste, accumulated from 40 years of nuclear weapons production. Before the waste can be disposed of, it must first be safely transported from generator storage sites to the WIPP. To accomplish this, the TRUPACT-II was designed and fabricated. This double containment, non-vented waste packaging successfully completed a rigorous testing program, and in 1989 received a Certificate of Compliance (C of C) from the Nuclear Regulatory Commission (NRC). Currently, the TRUPACT-II is in use at Idaho National Engineering Laboratory to transport waste on site for characterization. The DOE/CAO is responsible for maintaining the TRUPACT-II C of C. The C of C requires performance of nondestructive examination (NDE), e.g., visual testing (VT), dimensional inspections, Liquid Dye Penetrant testing (PT), and Helium Leak Detection (HLD). The Waste Isolation Division (WID) uses HLD for verification of the containment integrity. The following HLD tests are performed on annual basis or when required, i.e. repairs or component replacement: (1) fabrication verification leak tests on both the outer containment vessel (OCV) and the inner containment vessel (ICV); (2) assembly verification leak tests on the OCV and ICV upper main o-rings; and (3) assembly verification leak tests on the OCV and the ICV vent port plugs. These tests are addressed in detail as part of this presentation.

  9. The regulatory quagmire underlying the TOPAZ II exhibition: The nuclear regulatory commission's jurisdiction over the TOPAZ II reactor system

    NASA Astrophysics Data System (ADS)

    Lawrence, John W.

    1992-01-01

    At the 8th Symposium on Space Nuclear Power Systems, 6-10 January 1990, the Union of Soviet Socialist Republics displayed a TOPAZ II thermionic space nuclear reactor. Underlying that exhibition was a regulatory quagmire created by a decision of the Nuclear Regulatory Commission that an import license was required to bring the device into the United States, and that an amendment to their regulations governing exports was required to return the device to the Soviet Union latter that summer. This paper briefly reviews the jurisdictional issue of how the Nuclear Regulatory Commission exerted its authority over the TOPAZ II reactor system, as well as the manner in which the import and export licensing actions were accomplished. In sum, the paper offers an independent interpretation of the applicable import and export regulations, and concludes that the Nuclear Regulatory Commission likely need not have exercised its import jurisdiction, and notwithstanding the initial assumption of jurisdiction, an export license likely could have been issued without an amendment to the then existing regulations.

  10. Creating a Comprehensive, Efficient, and Sustainable Nuclear Regulatory Structure: A Process Report from the U.S. Department of Energy's Material Protection, Control and Accounting Program

    SciTech Connect

    Wright, Troy L.; O'Brien, Patricia E.; Hazel, Michael J.; Tuttle, John D.; Cunningham, Mitchel E.; Schlegel, Steven C.

    2010-08-11

    With the congressionally mandated January 1, 2013 deadline for the U.S. Department of Energy’s (DOE) Nuclear Material Protection, Control and Accounting (MPC&A) program to complete its transition of MPC&A responsibility to the Russian Federation, National Nuclear Security Administration (NNSA) management directed its MPC&A program managers and team leaders to demonstrate that work in ongoing programs would lead to successful and timely achievement of these milestones. In the spirit of planning for successful project completion, the NNSA review of the Russian regulatory development process confirmed the critical importance of an effective regulatory system to a sustainable nuclear protection regime and called for an analysis of the existing Russian regulatory structure and the identification of a plan to ensure a complete MPC&A regulatory foundation. This paper describes the systematic process used by DOE’s MPC&A Regulatory Development Project (RDP) to develop an effective and sustainable MPC&A regulatory structure in the Russian Federation. This nuclear regulatory system will address all non-military Category I and II nuclear materials at State Corporation for Atomic Energy “Rosatom,” the Federal Service for Ecological, Technological, and Nuclear Oversight (Rostechnadzor), the Federal Agency for Marine and River Transport (FAMRT, within the Ministry of Transportation), and the Ministry of Industry and Trade (Minpromtorg). The approach to ensuring a complete and comprehensive nuclear regulatory structure includes five sequential steps. The approach was adopted from DOE’s project management guidelines and was adapted to the regulatory development task by the RDP. The five steps in the Regulatory Development Process are: 1) Define MPC&A Structural Elements; 2) Analyze the existing regulatory documents using the identified Structural Elements; 3) Validate the analysis with Russian colleagues and define the list of documents to be developed; 4) Prioritize and

  11. 75 FR 36698 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1216, ``Plant-Specific Applicability of Transition Break Size Specified in 10 CFR...

  12. 75 FR 27599 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 6.7, Revision 2, ``Preparation of an Environmental Report To... The U.S. Nuclear Regulatory Commission (NRC) is issuing a revision to an existing guide in the...

  13. 75 FR 62436 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.54, Revision 2, ``Service Level I, II, and III Protective.... Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing a revision to an existing guide in...

  14. 75 FR 42170 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide, RG 8.40, ``Methods for Measuring Effective Dose... . SUPPLEMENTARY INFORMATION: I. Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing a new...

  15. 75 FR 19665 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide (RG) 1.65, Revision 1, ``Materials and Inspections for Reactor Vessel Closure Studs.'' FOR...

  16. 76 FR 14107 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.43, Revision 1, ``Control of Stainless Steel Weld Cladding of Low-Alloy Components.'' FOR...

  17. Agency for Nuclear Projects/Nuclear Waste Project Office final progress report

    SciTech Connect

    1992-12-31

    The Nevada Agency for Nuclear Projects/Nuclear Waste Project Office (NWPO) was formally established by Executive Policy in 1983 following passage of the federal Nuclear Waste Policy Act of 1982 (Act). That Act provides for the systematic siting, construction, operation, and closure of high-level radioactive defense and research by-products and other forms of high-level radioactive waste from around the country which will be stored at such repositories. In 1985 the Nevada legislature formally established the NWPO as a distinct and statutorily authorized agency to provide support to the Governor and State Legislature on matters concerning the high-level nuclear waste programs. The NWPO utilized a small, central staff supplemented by contractual services for needed technical and specialized expertise in order to provide high quality oversight and monitoring of federal activities, to conduct necessary independent studies, and to avoid unnecessary duplication of efforts. This report summarizes the results of this ongoing program to ensure that risks to the environment and to human safety are minimized. It includes findings in the areas of hydrogeology, geology, quality assurance activities, repository engineering, legislature participation, socioeconomic affects, risk assessments, monitoring programs, public information dissemination, and transportation activities. The bulk of the reporting deals with the Yucca Mountain facility.

  18. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  19. 10 CFR 30.12 - Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Persons using byproduct material under certain Department of Energy and Nuclear Regulatory Commission contracts. 30.12 Section 30.12 Energy NUCLEAR REGULATORY... Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

  20. 10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent...

  1. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  2. 10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent...

  3. 10 CFR 30.12 - Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Persons using byproduct material under certain Department of Energy and Nuclear Regulatory Commission contracts. 30.12 Section 30.12 Energy NUCLEAR REGULATORY... Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

  4. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  5. 10 CFR Appendix A to Part 5 - List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Regulatory Commission to Which Title IX Applies A Appendix A to Part 5 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission to Which Title IX Applies Note: All recipients of Federal financial assistance from NRC are subject to Title IX, but Title IX's anti-discrimination prohibitions are limited...

  6. 10 CFR Appendix A to Part 5 - List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nuclear Regulatory Commission to Which Title IX Applies A Appendix A to Part 5 Energy NUCLEAR REGULATORY... the Nuclear Regulatory Commission to Which Title IX Applies Note: All recipients of Federal financial assistance from NRC are subject to Title IX, but Title IX's anti-discrimination prohibitions are limited...

  7. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  8. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  9. 10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent...

  10. 10 CFR 30.12 - Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Persons using byproduct material under certain Department of Energy and Nuclear Regulatory Commission contracts. 30.12 Section 30.12 Energy NUCLEAR REGULATORY... Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

  11. NRC (Nuclear Regulatory Commission) perspective of software QA (quality assurance) in the nuclear history

    SciTech Connect

    Weiss, S.H.

    1988-01-01

    Computer technology has been a part of the nuclear industry since its inception. However, it is only recently that computers have been integrated into reactor operations. During the early history of commercial nuclear power in the United States, the US Nuclear Regulatory Commission (NRC) discouraged the use of digital computers for real-time control and monitoring of nuclear power plant operation. At the time, this position was justified since software engineering was in its infancy, and horror stories on computer crashes were plentiful. Since the advent of microprocessors and inexpensive computer memories, significant advances have been made in fault-tolerant computer architecture that have resulted in highly reliable, durable computer systems. The NRC's requirement for safety parameter display system (SPDS) stemmed form the results of studies and investigations conducted on the Three Mile Island Unit 2 (TMI-2) accident. An NRC contractor has prepared a handbook of software QA techniques applicable to the nuclear industry, published as NUREG/CR-4640 in August 1987. Currently, the NRC is considering development of an inspection program covering software QA. Future efforts may address verification and validation as applied to expert systems and artificial intelligence programs.

  12. The role of bureaucratic expertise in nuclear waste policy: Agency power and policy development

    SciTech Connect

    Henkels, M.

    1989-01-01

    The role of agency expertise in the nuclear waste policy process is explored during three periods: (1) 1957-1959 when nuclear wastes entered the public agenda, (2) 1970-1972 when the Atomic Energy Commission attempted to establish a waste repository in Kansas, and (3) 1984-1986 during the Department of Energy's implementation of the Nuclear Waste Policy Act of 1982. The study evaluated whether the preconditions for dependence on or deference to agency expertise have become less favorable, weakening agency control of the policy process. Five factors of expertise power are evaluated, beginning with the agency's role in the nuclear-energy and radioactive-waste information system. Perspectives on nuclear energy generally and of waste issues specifically are examined next; both indicate attitudes on the tractability of the problem and the likelihood of policy success. References to agency behavior and policies are used to evaluate views of agency competency. Finally, views of agency trustworthiness are examined through the comparison of portrayals of agency priorities and motivations. Agency expertise is evaluated in four contexts: (1) Congressional hearings, (2) nationally prominent newspapers, (3) journals of the scientific community, and (4) state and local papers of affected areas. State and tribal officials involved in the 1980s' nuclear waste policy process were surveyed also.

  13. 77 FR 76541 - Entergy Nuclear Operations, Inc.; Pilgrim Nuclear Power Station

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Pilgrim Nuclear Power Station AGENCY: Nuclear Regulatory.... Introduction The U.S. Nuclear Regulatory Commission (NRC) is considering issuance of an exemption from Title...

  14. 41 CFR 102-117.335 - How does my agency ask for a delegation to represent itself in a regulatory body proceeding?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for a delegation to represent itself in a regulatory body proceeding? 102-117.335 Section 102-117.335... Regulatory Body Proceedings § 102-117.335 How does my agency ask for a delegation to represent itself in a regulatory body proceeding? You must send your request for delegation with enough detail to explain...

  15. 41 CFR 102-117.335 - How does my agency ask for a delegation to represent itself in a regulatory body proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for a delegation to represent itself in a regulatory body proceeding? 102-117.335 Section 102-117.335... Regulatory Body Proceedings § 102-117.335 How does my agency ask for a delegation to represent itself in a regulatory body proceeding? You must send your request for delegation with enough detail to explain...

  16. 41 CFR 102-117.335 - How does my agency ask for a delegation to represent itself in a regulatory body proceeding?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for a delegation to represent itself in a regulatory body proceeding? 102-117.335 Section 102-117.335... Regulatory Body Proceedings § 102-117.335 How does my agency ask for a delegation to represent itself in a regulatory body proceeding? You must send your request for delegation with enough detail to explain...

  17. 41 CFR 102-117.335 - How does my agency ask for a delegation to represent itself in a regulatory body proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for a delegation to represent itself in a regulatory body proceeding? 102-117.335 Section 102-117.335... Regulatory Body Proceedings § 102-117.335 How does my agency ask for a delegation to represent itself in a regulatory body proceeding? You must send your request for delegation with enough detail to explain...

  18. 41 CFR 102-117.335 - How does my agency ask for a delegation to represent itself in a regulatory body proceeding?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for a delegation to represent itself in a regulatory body proceeding? 102-117.335 Section 102-117.335... Regulatory Body Proceedings § 102-117.335 How does my agency ask for a delegation to represent itself in a regulatory body proceeding? You must send your request for delegation with enough detail to explain...

  19. 77 FR 15142 - Updated Nuclear Regulatory Commission Fiscal Years 2008-2013 Strategic Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... 2012-2016 in the Federal Register for public comment on October 4, 2011 (76 FR 61402). NRC's Senior... ``Commission'') is announcing the availability of NUREG-1614, Volume 5, ``U.S. Nuclear Regulatory...

  20. 78 FR 49726 - International Framework for Nuclear Energy Cooperation Finance/Regulatory/Energy Planning...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... International Trade Administration International Framework for Nuclear Energy Cooperation Finance/ Regulatory... U.S. industry in the IFNEC Finance, Regulatory, and Energy Planning Authority Workshop, to be held... IFNEC Executive Committee accepted the Final Summary Report of the 2012 London IFNEC Finance Workshop...

  1. ICH: an exclusive club of drug regulatory agencies and drug companies imposing its rules on the rest of the world.

    PubMed

    2010-08-01

    Under the pretext of harmonising regulatory requirements for marketing authorisation of new drugs, the drug regulatory agencies of the world's wealthiest countries and three pharmaceutical industry trade associations, joined together since 1990 in the ICH, are promoting their own interests by imposing their criteria for evaluating drugs on the whole world. The toxicity standards advocated by ICH sometimes promote faster, cheaper drug development over patient protection. The drug quality standards advocated by ICH sometimes increase manufacturing costs without providing any public health benefit. It would be preferable if the World Health Organization were in charge of setting standards for drug development, focusing on patients' interests. PMID:20939460

  2. The International Atomic Energy Agency and world nuclear order

    SciTech Connect

    Scheinman, L.

    1987-01-01

    In this book, the author assesses the structure and functions of the International Atomic Energy Agency (IAEA), identifies key issues confronting the agency today, and offers recommendations for dealing with the challenges it faces. The author traces the background and origins of the IAEA from the Baruch Plan, through Atoms for Peace, to negotiations resulting in the establishment of the agency. He also describes special structural characteristics of the agency and their evolution - in particular, the board of governors, the general conference, and the secretariat.

  3. Importance of loss-of-benefits considerations in nuclear regulatory decision-making

    SciTech Connect

    Buehring, W.A.; Peerenboom, J.P.

    1982-01-01

    This paper identifies and discusses some of the important consequences of nuclear power plant unavailability, and quantifies a number of technical measures of loss of benefits that may help the Nuclear Regulatory Commission make decisions involving nuclear power plant licensing and operation. The loss-of-benefits analysis presented here is based on the results of a series of case studies developed by Argonne National Laboratory in cooperation with four electric utilities on hypothetical nuclear plant shutdowns.

  4. Nuclear Regulatory Commission issuances, June 1996. Volume 43, Number 6

    SciTech Connect

    1996-06-01

    This report covers the issuances received during the specified period form the Commission, the Atomic Safety and licensing Boards, the administrative Law Judges, the Director`s decisions and the Decisions on Petitions for Rulemaking. Included are a memorandum and order on the decommissioning plan for Yankee Nuclear Power Station, a memorandum and order suspending byproduct material license for Eastern Testing and Inspection, Inc., an initial decision of the source materials license for Sequoyah Fuels Corporation, Director`s decisions for Palo Verde Nuclear Generating Station, Indian Point, Peach Bottom Atomic Power Station, Trojan Nuclear Plant, Rancho Seco Nuclear Generating Station, San Onofre Nuclear Generating Station, and Yankee Nuclear Power Station.

  5. The development of regulatory expectations for computer-based safety systems for the UK nuclear programme

    SciTech Connect

    Hughes, P. J.; Westwood, R.N; Mark, R. T.; Tapping, K.

    2006-07-01

    The Nuclear Installations Inspectorate (NII) of the UK's Health and Safety Executive (HSE) has completed a review of their Safety Assessment Principles (SAPs) for Nuclear Installations recently. During the period of the SAPs review in 2004-2005 the designers of future UK naval reactor plant were optioneering the control and protection systems that might be implemented. Because there was insufficient regulatory guidance available in the naval sector to support this activity the Defence Nuclear Safety Regulator (DNSR) invited the NII to collaborate with the production of a guidance document that provides clarity of regulatory expectations for the production of safety cases for computer based safety systems. A key part of producing regulatory expectations was identifying the relevant extant standards and sector guidance that reflect good practice. The three principal sources of such good practice were: IAEA Safety Guide NS-G-1.1 (Software for Computer Based Systems Important to Safety in Nuclear Power Plants), European Commission consensus document (Common Position of European Nuclear Regulators for the Licensing of Safety Critical Software for Nuclear Reactors) and IEC nuclear sector standards such as IEC60880. A common understanding has been achieved between the NII and DNSR and regulatory guidance developed which will be used by both NII and DNSR in the assessment of computer-based safety systems and in the further development of more detailed joint technical assessment guidance for both regulatory organisations. (authors)

  6. 75 FR 54918 - Draft Regulatory Guide, DG-1247, “Design-Basis Hurricane and Hurricane Missiles for Nuclear Power...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... August 31, 2010 (75 FR 53352), the U.S. Nuclear Regulatory Commission (NRC) published a notice of issuance and availability of Draft Regulatory Guide (DG)--1247, ``Design-Basis Hurricane and Hurricane... COMMISSION Draft Regulatory Guide, DG-1247, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear...

  7. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  8. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  9. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  10. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  11. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  12. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Scroggins, Sharon; Duda, Kristen

    2008-01-01

    This viewgraph presentation gives an overview of NASA's risk analysis communication programs associated with changing environmental policies. The topics include: 1) NASA Program Transition; 2) Principal Center for Regulatory Risk Analysis and Communication (RRAC PC); and 3) Regulatory Tracking and Communication Process.

  13. 78 FR 74175 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... for the Collection of Qualitative Feedback on Agency Service Delivery AGENCY: Nuclear Regulatory... streamline the process to seek feedback from the public on service delivery, the U.S. Nuclear Regulatory... for the Collection of Qualitative Feedback on Agency Service Delivery'' to OMB for approval under...

  14. Delivering Regulatory Consents for Decommissioning and Restoration of the Dounreay Nuclear Licensed Site

    SciTech Connect

    Crawford, R.W.; Zyda, P.W.

    2006-07-01

    On behalf of the Nuclear Decommissioning Authority (NDA) the United Kingdom Atomic Energy Authority (UKAEA) has implemented a strategy to translate the near-term Dounreay restoration plan into a suite of land use documents designed to deliver the necessary planning consents to decommission and restore the Dounreay Nuclear Licensed Site. The legal consents and authorizations required to enable UKAEA to commence major projects and progress the decommissioning of the site are highlighted along with the measures taken to secure political, public and regulatory acceptance at the earliest opportunity. The approach taken by UKAEA is explained, focusing particularly on the critical need to secure planning permission and stakeholder approval well before the onset of construction works. The intention is to realize the benefits of forging a close working relationship with the land use regulator, The Highland Council. UKAEA has taken an approach to suitably inform the planning authority, in particular, the production of the Dounreay Planning Framework (DPF) document. This paper describes the role and need for the DPF, focusing on the key purpose of amending the local development plan to secure supportive planning policies and to set a land use context for the subsequent site decommissioning and restoration. This also has the advantage of securing public acceptance through an established legal process. Strategic milestones subsequent to the Highland Council's adoption of the DPF are highlighted, including the submission of phased planning applications and compliance with environmental legislation generally. The paper describes and underscores the need for early engagement of other regulators in the planning process such as the Scottish Environment Protection Agency (SEPA), and the safety regulator, the Nuclear Installations Inspectorate (NII). It describes the linkages amongst land use consents, Best Practicable Environmental Options (BPEO), radioactive substances

  15. NRC (Nuclear Regulatory Commission) staff evaluation of the General Electric Company Nuclear Reactor Study (''Reed Report'')

    SciTech Connect

    1987-07-01

    In 1975, the General Electric Company (GE) published a Nuclear Reactor Study, also referred to as ''the Reed Report,'' an internal product-improvement study. GE considered the document ''proprietary'' and thus, under the regulations of the Nuclear Regulatory Commission (NRC), exempt from mandatory public disclosure. Nonetheless, members of the NRC staff reviewed the document in 1976 and determined that it did not raise any significant new safety issues. The staff also reached the same conclusion in subsequent reviews. However, in response to recent inquiries about the report, the staff reevaluated the Reed Report from a 1987 perspective. This re-evaluation, documented in this staff report, concluded that: (1) there are no issues raised in the Reed Report that support a need to curtail the operation of any GE boiling water reactor (BWR); (2) there are no new safety issues raised in the Reed Report of which the staff was unaware; and (3) although certain issues addressed by the Reed Report are still being studied by the NRC and the industry, there is no basis for suspending licensing and operation of GE BWR plants while these issues are being resolved.

  16. 75 FR 61531 - Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... COMMISSION Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice. SUMMARY: The... Guide 1.193, Rev. 3, ``ASME Code Cases Not Approved for Use.'' FOR FURTHER INFORMATION CONTACT: Wallace... Wallace.Norris@nrc.gov . SUPPLEMENTARY INFORMATION: I. Introduction The NRC is issuing Regulatory...

  17. Use of social science-based analysis in bureaucratic decision making: regulatory analysis in the Environmental Protection Agency

    SciTech Connect

    Mogee, M.E.

    1983-01-01

    This dissertation studies the use of regulatory analysis (a form of cost-benefit analysis) in Environmental Protection Agency (EPA) decision making. It addresses the questions of how the analysis was used, what influence it had on the regulations, and what the major factors were that affected its use. Case studies were conducted of six EPA rule makings during the period 1978 to 1980, including: Premanufacture Notification under TSCA Section 5; the Carbon Monoxide National Ambient Air Quality Standard; Visibility Protection; Light-Duty Truck gaseous emissions; effluent guidelines for Timber Products industries; and Motorcycle Noise standards. Data for the cases came from official documents and interviews with EPA participants. Regulatory analysis was used in EPA regulation development in six ways: in decision making, to support or legitimate, in intra-agency partisan negotiations, to review or exercise quality control, to describe or educate, and in external relations. The influence of the analysis on the regulations in these cases varied from almost none to moderately high. Even in those cases where the analysis was used in decision making and had relatively high influence, however, it was only one of many factors affecting the regulation. The major factors found to affect the use of regulatory analysis, in addition to the overall context set by EPA's regulation development process, were: the statute; program considerations; the existence of a tradition of economic analysis; the structure and quality of the analysis itself; the timing of the analysis with respect to the rule making; and scientific, technical, and implementation uncertainties.

  18. Regulatory accountability: Telecommunications and electricity agencies in the United Kingdom, France and Sweden

    NASA Astrophysics Data System (ADS)

    Rubinstein, Dorit

    2007-12-01

    This dissertation examines how administrative agencies deal with multiple and conflicting accountability pressures. Drawing on an empirical study of six agencies, the telecommunications and electricity regulators of the UK, France and Sweden, it describes how the agencies legitimized their behavior in relation to three major issues, network pricing, universal service and retail competition. I find that agencies use different forms of accountability in different circumstances, and suggest a classification of accountability strategies along two dimensions: internalizing v. externalizing authority, and the breadth of the target audience. What explains variations along these dimensions is the task characteristics of the issue an agency is dealing with, and specifically, its informational aspects and the degree of political controversy associated with it. The more an issue requires expertise, the more an agency will seek to rely on its professional judgment. The more an issue can be addressed only in terms of the values surrounding it, the more an agency will seek to externalize authority and defer to other actors. Also, the more politically controversial an issue, the broader the target audience before whom an agency will try to justify itself.

  19. 77 FR 27113 - Export and Import of Nuclear Equipment and Material; Export of International Atomic Energy Agency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ...) part 110, ``Export and Import of Nuclear Equipment and Material,'' to current nuclear non-proliferation... and import of nuclear materials and equipment. This rulemaking is necessary to reflect the nuclear non... OMB control number. Regulatory Analysis This rulemaking is necessary to reflect the nuclear...

  20. The U.S. Nuclear Regulatory Commission's Strategy for Revising the RIA Acceptance Criteria

    SciTech Connect

    Clifford, Paul M.

    2007-07-01

    The U.S. Nuclear Regulatory Commission (NRC) has issued interim criteria and guidance for the reactivity-initiated accident (RIA) within the latest revision to NUREG-0800, 'Standard Review Plan' (SRP), Section 4.2, 'Fuel System Design', Appendix B (Revision 03, March 2007). The purpose of this paper is as follows: 1. present a change in regulatory staff position regarding the requirements of 10 CFR 50, Appendix A, General Design Criteria 28 (GDC28) and changes in regulatory guidance provided in Regulatory Guide (RG) 1.77, RG 1.195, RG 1.183, and previous versions of NUREG-0800 SRP; 2. describe the implementation strategy and schedule for both new reactors and the existing fleet; and 3. encourage licensees and nuclear fuel vendors to (1) develop improved core physics analytical methods to allow a more deliberate transition to the new fuel cladding failure criteria and (2) develop the technical basis to address the new core coolability criteria. (authors)

  1. 75 FR 52999 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 8.35, Revision 1, ``Planned Special Exposure.'' FOR FURTHER INFORMATION CONTACT: R. A. Jervey, Regulatory Guide Development Branch, Division of Engineering, Office...

  2. 75 FR 37842 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 2.5, Revision 1, ``Quality Assurance Program Requirements for Research and Test Reactors''. FOR FURTHER INFORMATION CONTACT: R. A. Jervey, Regulatory Guide...

  3. 75 FR 16525 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.11, Revision 1, ``Instrument Lines Penetrating the Primary Reactor Containment.'' FOR FURTHER INFORMATION CONTACT: Mekonen M. Bayssie, Regulatory Guide...

  4. Nuclear Regulatory Commission issuances, Volume 44, No. 4

    SciTech Connect

    1996-10-01

    This report includes the issuances received in October 1996. Issuances are from the Commission, the Atomic Safety and Licensing Boards, and the Directors` Decisions. 15 issuances were received and are abstracted individually in the database: Louisiana Energy Services, U.S. Enrichment Corporation, Yankee Atomic Electric Company, General Public Utilities Nuclear Corporation, James L. Shelton, Juan Guzman, Northern States Power Company, TESTCO Inc., Washington Public Power Supply System, all nuclear plants, Cleveland Electric Illuminating Company, Duke Power Company, Florida Power Corporation, and Northeast Nuclear Energy Company (2 issuances). No issuances were received from the the Administrative Law Judges or the Decisions on Petitions for Rulemaking.

  5. Risk-informed assessment of regulatory and design requirements for future nuclear power plants. Annual report

    SciTech Connect

    2000-08-01

    OAK B188 Risk-informed assessment of regulatory and design requirements for future nuclear power plants. Annual report. The overall goal of this research project is to support innovation in new nuclear power plant designs. This project is examining the implications, for future reactors and future safety regulation, of utilizing a new risk-informed regulatory system as a replacement for the current system. This innovation will be made possible through development of a scientific, highly risk-formed approach for the design and regulation of nuclear power plants. This approach will include the development and/or confirmation of corresponding regulatory requirements and industry standards. The major impediment to long term competitiveness of new nuclear plants in the U.S. is the capital cost component--which may need to be reduced on the order of 35% to 40% for Advanced Light Water Reactors (ALWRS) such as System 80+ and Advanced Boiling Water Reactor (ABWR). The required cost reduction for an ALWR such as AP600 or AP1000 would be expected to be less. Such reductions in capital cost will require a fundamental reevaluation of the industry standards and regulatory bases under which nuclear plants are designed and licensed. Fortunately, there is now an increasing awareness that many of the existing regulatory requirements and industry standards are not significantly contributing to safety and reliability and, therefore, are unnecessarily adding to nuclear plant costs. Not only does this degrade the economic competitiveness of nuclear energy, it results in unnecessary costs to the American electricity consumer. While addressing these concerns, this research project will be coordinated with current efforts of industry and NRC to develop risk-informed, performance-based regulations that affect the operation of the existing nuclear plants; however, this project will go further by focusing on the design of new plants.

  6. Cost savings from nuclear regulatory reform: An econometric model

    SciTech Connect

    Canterbery, E.R. |; Johnson, B.; Reading, D.

    1996-01-01

    The nuclear-generated power touted in the 1950s as someday being {open_quotes}too cheap to meter{close_quotes} got dismissed in the 1980s as incapable of being both safe and cost effective. Today, less than 20 percent of American`s electricity is nuclear-generated, no new plants are planned or on order, and some of the earliest units are scheduled for decommissioning within the next decade. Even so, interest in nuclear power has been revived by increasing energy demands, concerns about global warming, and the uncertainty surrounding oil resources in the Persian Gulf. As a long-term alternative to fossil fuels, atomic energy offers the important advantages of clean air and domestic availability of fuel. But these advantages will count for little unless and until the costs of nuclear power can be seen as reasonable. The authors premise is that the relevant costs are those of providing safe and environmentally clean electric energy. To the extent that increased costs have resulted from increasingly stringent regulations, they reflect the internalization of external costs. Indeed, the external costs of nuclear power (particularly safety and environmental protection) have been internalized to a greater degree than with most alternative fuel sources used by electric utilities. Nuclear construction costs are properly compared with those of alternative sources only after the latter are adjusted for environmental damage and endangerment, including, as examples, the costs of oil spills, of building double-hulled tankers, and of building off-shore offloading facilities. A shift to nuclear sources could reduce these costs whereas it would increase disposal costs for radioactive materials. The authors contend that a better understanding of nuclear plant construction costs is pivotal to a balanced evaluation of the merits of uranium relative to other fuel choices. 12 refs., 2 figs., 5 tabs.

  7. Nuclear Regulatory Commission Issuances, Volume 42, No. 2

    SciTech Connect

    1995-08-01

    This report include the issuances received during the specificed period (August 1995) from the NRC, the Atomic Safety and Licensing Boards, the Administrative Law Judges, and the Decisions on Petitions for Rule Making. In these issuances, the following areas were addressed: (1) Emergency planning at the University of Missouri, (2) Transfer of operating license at Plant Vogtle, (3) Discriminatory action against a whistle-blower at Millstone Units 1 & 2, (4) Regulatory issues related to embittlement and cracking at Oyster Creek, and (5) Age-related deterioration of reactor internals components at Pilgrim.

  8. Summary of the financial and ratepayer impacts of nuclear power plant regulatory reform

    SciTech Connect

    Turpin, A.Y.

    1985-05-01

    This report estimates the financial impact on utilities and ratepayers of nuclear power plant regulatory reforms. Three situations are investigated: (1) no reform, (2) combined early-site-permit and preapproval-of-design reforms, and (3) total reform. Also, two types of capacity additions are evaluated using two utility companies as case studies: (1) nuclear plus generic capacity, and (2) all-nuclear capacity. Results indicate that both the shorter construction lead-time afforded by nuclear regulatory reform and the timing of new capacity additions are extremely important in enabling a utility to remain in a healthy financial position while adding capacity to meet future demand and at the same time reducing the price of electricity to the ratepayers. The lower added capital costs and fuel cost savings obtained from reformed nuclear units allow a utility dependent on oil and gas steam generation to experience price decreases as these new units begin commercial operation. The study also points out that in simulations excluding the shorter lead-time generic capacity, price increases were greater and financial performance was worse for both utilities. These facts indicate the importance of shortening the construction lead-time through nuclear regulatory reform so that nuclear power will be more competitive with coal. 19 refs., 4 figs., 3 tabs.

  9. Dynamic SPR monitoring of yeast nuclear protein binding to a cis-regulatory element

    SciTech Connect

    Mao, Grace; Brody, James P.

    2007-11-09

    Gene expression is controlled by protein complexes binding to short specific sequences of DNA, called cis-regulatory elements. Expression of most eukaryotic genes is controlled by dozens of these elements. Comprehensive identification and monitoring of these elements is a major goal of genomics. In pursuit of this goal, we are developing a surface plasmon resonance (SPR) based assay to identify and monitor cis-regulatory elements. To test whether we could reliably monitor protein binding to a regulatory element, we immobilized a 16 bp region of Saccharomyces cerevisiae chromosome 5 onto a gold surface. This 16 bp region of DNA is known to bind several proteins and thought to control expression of the gene RNR1, which varies through the cell cycle. We synchronized yeast cell cultures, and then sampled these cultures at a regular interval. These samples were processed to purify nuclear lysate, which was then exposed to the sensor. We found that nuclear protein binds this particular element of DNA at a significantly higher rate (as compared to unsynchronized cells) during G1 phase. Other time points show levels of DNA-nuclear protein binding similar to the unsynchronized control. We also measured the apparent association complex of the binding to be 0.014 s{sup -1}. We conclude that (1) SPR-based assays can monitor DNA-nuclear protein binding and that (2) for this particular cis-regulatory element, maximum DNA-nuclear protein binding occurs during G1 phase.

  10. Nuclear Energy Research Initiative. Risk Informed Assessment of Regulatory and Design Requirements for Future Nuclear Power Plants. Annual Report

    SciTech Connect

    Ritterbusch, S.E.

    2000-08-01

    The overall goal of this research project is to support innovation in new nuclear power plant designs. This project is examining the implications, for future reactors and future safety regulation, of utilizing a new risk-informed regulatory system as a replacement for the current system. This innovation will be made possible through development of a scientific, highly risk-informed approach for the design and regulation of nuclear power plants. This approach will include the development and.lor confirmation of corresponding regulatory requirements and industry standards. The major impediment to long term competitiveness of new nuclear plants in the U.S. is the capital cost component--which may need to be reduced on the order of 35% to 40% for Advanced Light Water Reactors (ALWRs) such as System 80+ and Advanced Boiling Water Reactor (ABWR). The required cost reduction for an ALWR such as AP600 or AP1000 would be expected to be less. Such reductions in capital cost will require a fundamental reevaluation of the industry standards and regulatory bases under which nuclear plants are designed and licensed. Fortunately, there is now an increasing awareness that many of the existing regulatory requirements and industry standards are not significantly contributing to safety and reliability and, therefore, are unnecessarily adding to nuclear plant costs. Not only does this degrade the economic competitiveness of nuclear energy, it results in unnecessary costs to the American electricity consumer. While addressing these concerns, this research project will be coordinated with current efforts of industry and NRC to develop risk-informed, performance-based regulations that affect the operation of the existing nuclear plants; however, this project will go farther by focusing on the design of new plants.

  11. 40 CFR 124.204 - What must I do as the Director of the regulatory agency to prepare a draft standardized permit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true What must I do as the Director of the regulatory agency to prepare a draft standardized permit? 124.204 Section 124.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for...

  12. 40 CFR 124.205 - What must I do as the Director of the regulatory agency to prepare a final standardized permit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true What must I do as the Director of the regulatory agency to prepare a final standardized permit? 124.205 Section 124.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PROCEDURES FOR DECISIONMAKING Procedures for...

  13. 48 CFR 2015.606 - Agency procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... proposal into the unsolicited proposal tracking system. ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Agency procedures. 2015.606 Section 2015.606 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION...

  14. 48 CFR 2015.606 - Agency procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... proposal into the unsolicited proposal tracking system. ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Agency procedures. 2015.606 Section 2015.606 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION...

  15. 48 CFR 2015.606 - Agency procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... proposal into the unsolicited proposal tracking system. ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Agency procedures. 2015.606 Section 2015.606 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION...

  16. 48 CFR 2015.606 - Agency procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposal into the unsolicited proposal tracking system. ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Agency procedures. 2015.606 Section 2015.606 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING...

  17. Nuclear Regulatory Commission issuances, January 1995. Volume 41, Number 1

    SciTech Connect

    1995-01-01

    This book contains issuances of the Atomic Safety and Licensing Boards for January 1995. The issuances include Babcock and Wilcox Company materials license; Hydro Resources, Inc. application for uranium mining; low-level waste storage in Utah; communication of emerging and existing generic, technical issues with PWR owners groups; and radioactive waste management by Sierra Nuclear Corporation.

  18. Competence of nuclear power plant operations personnel: The regulatory assessment process

    SciTech Connect

    Ishack, G.A.

    1994-12-31

    Assessment of the competence of nuclear power plant operations personnel constitutes an essential element in the overall regulatory process of ensuring that the use of nuclear energy does not pose undue risk to health, safety, security and the environment. This paper presents a review of the activities of the Operator Certification Division of the Canadian Atomic Energy Control Board, reports on its experience with simulator-based examinations and with training programme evaluation techniques and outlines the Division`s future plans.

  19. The Environmental Protection Agency's Safety Standards for Disposal of Spent Nuclear Fuel: Potential Path Forward in Response to the Report of the Blue Ribbon Commission on America's Nuclear Future - 13388

    SciTech Connect

    Forinash, Betsy; Schultheisz, Daniel; Peake, Tom

    2013-07-01

    Following the decision to withdraw the Yucca Mountain license application, the Department of Energy created a Blue Ribbon Commission (BRC) on America's Nuclear Future, tasked with recommending a national strategy to manage the back end of the nuclear fuel cycle. The BRC issued its final report in January 2012, with recommendations covering transportation, storage and disposal of spent nuclear fuel (SNF); potential reprocessing; and supporting institutional measures. The BRC recommendations on disposal of SNF and high-level waste (HLW) are relevant to the U.S. Environmental Protection Agency (EPA), which shares regulatory responsibility with the Nuclear Regulatory Commission (NRC): EPA issues 'generally applicable' performance standards for disposal repositories, which are then implemented in licensing. For disposal, the BRC endorses developing one or more geological repositories, with siting based on an approach that is adaptive, staged and consent-based. The BRC recommends that EPA and NRC work cooperatively to issue generic disposal standards-applying equally to all sites-early in any siting process. EPA previously issued generic disposal standards that apply to all sites other than Yucca Mountain. However, the BRC concluded that the existing regulations should be revisited and revised. The BRC proposes a number of general principles to guide the development of future regulations. EPA continues to review the BRC report and to assess the implications for Agency action, including potential regulatory issues and considerations if EPA develops new or revised generic disposal standards. This review also involves preparatory activities to define potential process and public engagement approaches. (authors)

  20. Nuclear Regulatory Commission Issuances. Opinions and decisions of the Nuclear Regulatory Commission with selected orders: July 1, 1992--December 31, 1992, Volume 36, Pages 1--396

    SciTech Connect

    Not Available

    1992-12-31

    This is the thirty-sixth volume of issuances (1-396) of the Nuclear Regulatory Commission and its Atomic Safety and Licensing Boards, Administrative Law Judges, and Office Directors. It covers the period from July 1, 1992-December 31, 1992. Atomic Safety and Licensing Boards are authorized by Section 191 of the Atomic Energy Act of 1954. These Boards, comprised of three members conduct adjudicatory hearings on applications to construct and operate nuclear power plants and related facilities and issue initial decisions which, subject to internal review and appellate procedures, become the final Commission action with respect to those applications. Boards are drawn from the Atomic Safety and Licensing Board Panel, comprised of lawyers, nuclear physicists and engineers, environmentalists, chemists, and economists. The Atomic Energy Commission first established Licensing Boards in 1962 and the Panel in 1967.

  1. 10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL Exemptions § 40.11 Persons using source material under certain Department of Energy and...

  2. 10 CFR 30.12 - Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Persons using byproduct material under certain Department of Energy and Nuclear Regulatory Commission contracts. 30.12 Section 30.12 Energy NUCLEAR REGULATORY COMMISSION RULES OF GENERAL APPLICABILITY TO DOMESTIC LICENSING OF BYPRODUCT MATERIAL Exemptions § 30.12 Persons using byproduct material...

  3. 10 CFR Appendix A to Part 5 - List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which Title IX Applies A Appendix A to Part 5 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 5, App. A...

  4. 10 CFR Appendix A to Part 5 - List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which Title IX Applies A Appendix A to Part 5 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 5, App. A...

  5. 10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL Exemptions § 40.11 Persons using source material under certain Department of Energy and...

  6. 10 CFR 30.12 - Persons using byproduct material under certain Department of Energy and Nuclear Regulatory...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Persons using byproduct material under certain Department of Energy and Nuclear Regulatory Commission contracts. 30.12 Section 30.12 Energy NUCLEAR REGULATORY COMMISSION RULES OF GENERAL APPLICABILITY TO DOMESTIC LICENSING OF BYPRODUCT MATERIAL Exemptions § 30.12 Persons using byproduct material...

  7. 10 CFR Appendix A to Part 5 - List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false List of Federal Financial Assistance Administered by the Nuclear Regulatory Commission to Which Title IX Applies A Appendix A to Part 5 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 5, App. A...

  8. Comparison and Analysis of Regulatory and Derived Requirements for Certain DOE Spent Nuclear Fuel Shipments; Lessons Learned for Future Spent Fuel Transportation Campaigns

    SciTech Connect

    Kramer, George L., Ph.D.; Fawcett, Rick L.; Rieke, Philip C.

    2003-02-27

    Radioactive materials transportation is stringently regulated by the Department of Transportation and the Nuclear Regulatory Commission to protect the public and the environment. As a Federal agency, however, the U.S. Department of Energy (DOE) must seek State, Tribal and local input on safety issues for certain transportation activities. This interaction has invariably resulted in the imposition of extra-regulatory requirements, greatly increasing transportation costs and delaying schedules while not significantly enhancing the level of safety. This paper discusses the results an analysis of the regulatory and negotiated requirements established for a July 1998 shipment of spent nuclear fuel from foreign countries through the west coast to the Idaho National Engineering and Environmental Laboratory (INEEL). Staff from the INEEL Nuclear Materials Engineering and Disposition Department undertook the analysis in partnership with HMTC, to discover if there were instances where requirements derived from stakeholder interactions duplicate, contradict, or otherwise overlap with regulatory requirements. The study exhaustively lists and classifies applicable Department of Transportation (DOT) and Nuclear Regulatory Commission (NRC) regulations. These are then compared with a similarly classified list of requirements from the Environmental Impact Statements (EIS) and those developed during stakeholder negotiations. Comparison and analysis reveals numerous attempts to reduce transportation risk by imposing more stringent safety measures than those required by DOT and NRC. These usually took the form of additional inspection, notification and planning requirements. There are also many instances of overlap with, and duplication of regulations. Participants will gain a greater appreciation for the need to understand the risk-oriented basis of the radioactive materials regulations and their effectiveness in ensuring safety when negotiating extra-regulatory requirements.

  9. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--March 31, 1989

    SciTech Connect

    Weiss, A.J.

    1989-08-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1988.

  10. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, October 1--December 31, 1988

    SciTech Connect

    Weiss, A J; Azarm, A; Baum, J W; Boccio, J L; Carew, J; Diamond, D J; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Haber, S B

    1989-07-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through September 30, 1988.

  11. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--June 30, 1988

    SciTech Connect

    Baum, J W; Boccio, J L; Diamond, D; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Hall, R E; Higgins, J C; Weiss, A J

    1988-12-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1987.

  12. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, July 1--September 30, 1988

    SciTech Connect

    Weiss, A J

    1989-02-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through June 30, 1988. 71 figs., 24 tabs.

  13. Nuclear Regulatory Commission issuances. Volume 44, Number 3

    SciTech Connect

    1996-09-01

    This report includes issuances received during September 1996. After reviewing in detail each of the claims made in this informal proceeding the presiding officer sustained the staff of the USNRC in its determination that the applicant did not pass the written portion of his examination to become a licensed operator of a nuclear power plant. In the proceeding concerning citizen group challenges to the decommissioning plan for the Rowe Yankee power station, the licensing board grants licensee Yankee Atomic Electric Company`s motion for summary disposition.

  14. Nuclear Regulatory Commission issuances, Volume 46, No. 4

    SciTech Connect

    1997-10-01

    This report includes the issuances received in October 1997. Issuances are from the Commission, the Atomic Safety and Licensing Boards, and the Directors` Decisions. Five issuances were received on the following subjects: (1) decontamination and decommissioning funding for Sequoyah Fuels Corporation and General Atomics; (2) involvement in NRC-licensed activities by Aharon Ben-Haim; (3) Barnett Industrial X-Ray, Inc.; (4) spent fuel storage installation at Northern States Power Company; and (5) Vermont Yankee Nuclear Power Station. No issuances were received from the the Administrative Law Judges or the Decisions on Petitions for Rulemaking.

  15. 76 FR 2924 - Proposed Generic Communications; Draft NRC Regulatory Issue Summary 2011-XX; Adequacy of Station...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... Electric Distribution System Voltages AGENCY: Nuclear Regulatory Commission. ACTION: Notice of opportunity... protection) setting bases and Transmission Network/ Offsite/Onsite station electric power system design bases... INFORMATION: ] NRC Regulatory Issue Summary 2011-XX; Adequacy of Station Electric Distribution System...

  16. 76 FR 72220 - Incorporation of Risk Management Concepts in Regulatory Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... for Light-Water Reactor Electric Generating Plants'' into NRC's regulations (Federal Register, 69 FR... COMMISSION Incorporation of Risk Management Concepts in Regulatory Programs AGENCY: Nuclear Regulatory... Commission) is considering development of a strategic vision to better incorporate risk management...

  17. NPP financial and regulatory risks-Importance of a balanced and comprehensive nuclear law for a newcomer country considering nuclear power programme

    SciTech Connect

    Manan, J. A. N. Abd Mostafa, N. A.; Salim, M. F.

    2015-04-29

    The nature of Nuclear Power Plant (NPP) projects are: long duration (10-15 years for new build), high capital investment, reasonable risks and highly regulated industries to meet national and international requirement on Safety, Security, Safeguards (3S) and Liabilities. It requires long term planning and commitment from siting to final disposal of waste/spent fuel. Potential financial and regulatory risks are common in massive NPP projects and will be magnified in the case of using unproven technology. If the risks are not properly managed, it can lead to high project and operation costs, and, fail to fulfil its objectives to provide compatible electricity prices and. energy security. To ensure successful, the government and investors need to ensure that the NPP project is bankable with low cost of project and funding, have fair treatment and proper risk mitigation, and able to complete on time with no cost overrun. One of the requirements as prerequisite for the development of NPP as stipulated by the International Atomic Energy Agency (IAEA) is the establishment of a Legal and Regulatory Framework. The main objective of nuclear law is to ensure that the activities and projects carried-out in the country are legal and compliant to national and international requirements. The law should also be able to provide fair treatment of risks on its activities that is acceptable to investors. The challenge for a newcomer country is to develop a balanced and comprehensive national nuclear law that meet these objectives while taking into consideration various stakeholders’ interest without compromising on safety, security, safeguard, liability requirements and other international obligations. This paper highlights the nature of NPP projects, its potential and associated financial and regulatory risks, and its major concerns and challenges. It proposes possible risks treatment and mitigation through the formulation of a balanced and comprehensive legislation by clear

  18. NPP financial and regulatory risks-Importance of a balanced and comprehensive nuclear law for a newcomer country considering nuclear power programme

    NASA Astrophysics Data System (ADS)

    Manan, J. A. N. Abd; Mostafa, N. A.; Salim, M. F.

    2015-04-01

    The nature of Nuclear Power Plant (NPP) projects are: long duration (10-15 years for new build), high capital investment, reasonable risks and highly regulated industries to meet national & international requirement on Safety, Security, Safeguards (3S) and Liabilities. It requires long term planning and commitment from siting to final disposal of waste/spent fuel. Potential financial and regulatory risks are common in massive NPP projects and will be magnified in the case of using unproven technology. If the risks are not properly managed, it can lead to high project and operation costs, and, fail to fulfil its objectives to provide compatible electricity prices and. energy security. To ensure successful, the government and investors need to ensure that the NPP project is bankable with low cost of project and funding, have fair treatment and proper risk mitigation, and able to complete on time with no cost overrun. One of the requirements as prerequisite for the development of NPP as stipulated by the International Atomic Energy Agency (IAEA) is the establishment of a Legal and Regulatory Framework. The main objective of nuclear law is to ensure that the activities and projects carried-out in the country are legal and compliant to national and international requirements. The law should also be able to provide fair treatment of risks on its activities that is acceptable to investors. The challenge for a newcomer country is to develop a balanced and comprehensive national nuclear law that meet these objectives while taking into consideration various stakeholders' interest without compromising on safety, security, safeguard, liability requirements and other international obligations. This paper highlights the nature of NPP projects, its potential and associated financial and regulatory risks, and its major concerns and challenges. It proposes possible risks treatment and mitigation through the formulation of a balanced and comprehensive legislation by clear

  19. Occupational Radiation Exposure at Commercial Nuclear Power Reactors and Other Facilities 2010, Prepared for the Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, May 2012

    SciTech Connect

    D. E. Lewis D. A. Hagemeyer Y. U. McCormick

    2012-07-07

    This report summarizes the occupational exposure data that are maintained in the U.S. Nuclear Regulatory Commission’s (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 2010 annual reports submitted by five of the seven categories of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. Because there are no geologic repositories for high-level waste currently licensed and no NRC-licensed low-level waste disposal facilities currently in operation, only five categories will be considered in this report. The annual reports submitted by these licensees consist of radiation exposure records for each monitored individual. These records are analyzed for trends and presented in this report in terms of collective dose and the distribution of dose among the monitored individuals. Annual reports for 2010 were received from a total of 190 NRC licensees. The summation of reports submitted by the 190 licensees indicated that 192,424 individuals were monitored, 81,961 of whom received a measurable dose. When adjusted for transient workers who worked at more than one licensee during the year, there were actually 142,471 monitored individuals and 62,782 who received a measurable dose. The collective dose incurred by these individuals was 10,617 person-rem, which represents a 12% decrease from the 2009 value. This decrease was primarily due to the decrease in collective dose at commercial nuclear power reactors, as well as a decrease in the collective dose for most of the other categories of NRC licensees. The number of individuals receiving a measurable dose also decreased, resulting in an average measurable dose of 0.13 rem for 2010. The average measurable dose is defined as the total effective dose equivalent (TEDE) divided by the number of individuals receiving a measurable dose. In calendar year 2010, the average annual collective dose per reactor for light water reactor

  20. Nuclear nonproliferation and safety: Challenges facing the International Atomic Energy Agency

    SciTech Connect

    Not Available

    1993-09-01

    The Chairman of the Senate Committee on Govermental Affairs asked the United States General Accounting Office (GAO) to review the safeguards and nuclear power plant safety programs of the International Atomic Energy Agency (IAEA). This report examines (1) the effectiveness of IAEA`s safeguards program and the adequacy of program funding, (2) the management of U.S. technical assistance to the IAEA`s safeguards program, and (3) the effectiveness of IAEA`s program for advising United Nations (UN) member states about nuclear power plant safety and the adequacy of program funding. Under its statute and the Treaty on the Non-Proliferation of Nuclear Weapons, IAEA is mandated to administer safeguards to detect diversions of significant quantities of nuclear material from peaceful uses. Because of limits on budget growth and unpaid contributions, IAEA has had difficulty funding the safeguards program. IAEA also conducts inspections of facilities or locations containing declared nuclear material, and manages a program for reviewing the operational safety of designated nuclear power plants. The U.S. technical assistance program for IAEA safeguards, overseen by an interagency coordinating committee, has enhanced the agency`s inspection capabilities, however, some weaknesses still exist. Despite financial limitations, IAEA is meeting its basic safety advisory responsibilities for advising UN member states on nuclear safety and providing requested safety services. However, IAEA`s program for reviewing the operational safety of nuclear power plants has not been fully effective because the program is voluntary and UN member states have not requested IAEA`s review of all nuclear reactors with serious problems. GAO believes that IAEA should have more discretion in selecting reactors for review.

  1. Counterintelligence and operations security-support program for the Defense Nuclear Agency. Directive

    SciTech Connect

    Nelson, L.

    1983-01-25

    The Directive establishes the counterintelligence (CI) and operations security (OPSEC) support program for the Defense Nuclear Agency which includes activities designed to protect classified and operationally sensitive unclassified information and material. Included are CI investigations, counterespionage and countersabotage operations, OPSEC analyses, technical surveillance countermeasures services, CI security education, and CI security assistance.

  2. 77 FR 9273 - WORKSHOP Sponsored by the Nuclear Regulatory Commission and the Electric Power Research Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... on the Treatment of Probabilistic Risk Assessment Uncertainties: Public Meeting AGENCY: U.S. Nuclear... (EPRI), will hold a joint workshop on the Treatment of Probabilistic Risk Assessment (PRA) Uncertainties..., ``Enhancing Public Participation in NRC Meetings,'' (67 FR 36920; May 28, 2002). The NRC provides...

  3. Government Performance and Results Act: Performance plan FY 1999, U.S. Nuclear Regulatory Commission. Volume 1

    SciTech Connect

    Fuches, J.L.

    1998-02-01

    The Nuclear Regulatory Commission`s (NRC) strategic plan [NUREG-1614, Vol. 1, September 1997] establishes a strategic framework that will guide future decision-making and will help the NRC continue to meet its responsibility for protecting public health and safety, promoting the common defense and security, and protecting the environment. This performance plan complements the agency`s strategic plan by setting annual goals with measurable target levels of performance for FY 1999, as required by the Government Performance and Results Act. No significant contribution was made to the preparation of the performance plan by any non-Federal entity. However, a contractor was used to help facilitate discussions and resolution of issues. Within six months after the close of FY 1999, the NRC will submit to the President and the Congress a report on program performance for FY 1999. This performance report will review the success of the agency in achieving the performance goals established for FY 1999. Where those goals have been achieved, the underlying assumptions and strategies will be examined to ensure that continued applicability is warranted in the future. If any of the FY 1999 performance goals are not met, the agency will conduct a thorough analysis of why it did not meet the goal and the actions necessary to meet-the goal in the future. One result of this analysis will be the documentation of plans and schedules for achieving the established performance goal. If the analysis should indicate that the performance goal is impractical or infeasible, the performance report will document why that is the case and what action is recommended.

  4. Training related research and development conducted at Oak Ridge National Laboratory for the US Nuclear Regulatory Commission

    SciTech Connect

    Haas, P.M.

    1985-01-01

    For a number of years Oak Ridge National Laboratory (ORNL) has conducted a sizeable program of human factors research and development in support of the Office of Nuclear Regulatory Research of the US Nuclear Regulatory Commission (NRC). The history of this effort has in many ways paralleled the growth of human factors R and D throughout the nuclear industry and the program has contributed to advances in the industry as well as to NRC regulatory and research programs. This paper reviews the major projects and products of the program relevant to training and concludes with an identification of future R and D needs.

  5. The safety goals of the U.S. Nuclear Regulatory Commission.

    PubMed

    Okrent, D

    1987-04-17

    In August 1986, after 6 years of effort, the U.S. Nuclear Regulatory Commission adopted a Policy Statement on safety goals for nuclear power reactors. The commission's qualitative goals state that individual members of the public should be provided a level of protection from the consequences of nuclear power plant operation such that they bear no significant additional risk to life and health, and societal risks to life and health from nuclear power should be comparable to or less than the risks of generating electricity by viable competing technologies and should not be a significant addition to other societal risks. The commission's safety goal Policy Statement also includes quantitative design objectives. PMID:3563510

  6. Artemisinin-based combination therapy in the treatment of uncomplicated malaria: review of recent regulatory experience at the European Medicines Agency

    PubMed Central

    Pelfrene, Eric; Pinheiro, Marie-Hélène; Cavaleri, Marco

    2015-01-01

    Malaria remains a major public health challenge with almost half of the world's population exposed to the risk of contracting the illness. Prompt, effective and well tolerated treatment remains one of the cornerstones in the disease management, with artemisinin-based combination therapy the recommended option for non-severe malaria in endemic areas with predominant Plasmodium falciparum infections. Recent experience has been obtained at the European Medicines Agency with regulatory approval of two such antimalarial fixed combination products. For these cases, two different regulatory pathways were applied. As such, the present contribution describes this experience, emphasising main differences and applicability offered by these regulatory choices. PMID:25855638

  7. 78 FR 35646 - Byron Nuclear Station, Units 1 and 2, and Braidwood Nuclear Station, Units 1 and 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Byron Nuclear Station, Units 1 and 2, and Braidwood Nuclear Station, Units 1 and 2 AGENCY: Nuclear... U.S. Nuclear Regulatory Commission (NRC) has received an application, dated May 29, 2013,...

  8. 75 FR 43208 - Withdrawal of Regulatory Guide 5.17

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... because the guidance is outdated. Former Sec. 73.31(e) has been deleted (44 FR 68184; November 28, 1979... COMMISSION Withdrawal of Regulatory Guide 5.17 AGENCY: Nuclear Regulatory Commission. ACTION: Withdrawal of Regulatory Guide 5.17, ``Truck Identification Markings''. FOR FURTHER INFORMATION CONTACT: Robert...

  9. 76 FR 19817 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Federal Register Notice was issued (74 FR 39343) announcing the availability of DG-5034 for public comment... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide (RG) 5.79, ``Protection of Safeguards...

  10. S. 946: A Bill to reorganize the functions of the Nuclear Regulatory Commission to promote more effective regulation of atomic energy for peaceful purposes. Introduced in the Senate of the United States, One Hundredth First Congress, First Session, May 9, 1989

    SciTech Connect

    Not Available

    1989-01-01

    S. 946 is a bill to reorganize the functions of the Nuclear Regulatory Commission to promote more effective regulation of atomic energy for peaceful purposes. The Bill proposes the reorganization of the NRC activities under the structure and functions of a Nuclear Safety Agency.

  11. 78 FR 75579 - License Renewal Application for Grand Gulf Nuclear Station, Unit 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION License Renewal Application for Grand Gulf Nuclear Station, Unit 1 AGENCY: Nuclear Regulatory... request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment...

  12. Independent Verification and Validation Of SAPHIRE 8 Software Project Plan Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Carl Wharton; Kent Norris

    2009-12-01

    This report provides an evaluation of the Project Plan. The Project Plan is intended to provide the high-level direction that documents the required software activities to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  13. Independent Verification and Validation Of SAPHIRE 8 Software Project Plan Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Carl Wharton; Kent Norris

    2010-03-01

    This report provides an evaluation of the Project Plan. The Project Plan is intended to provide the high-level direction that documents the required software activities to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  14. Independent Verification and Validation Of SAPHIRE 8 Software Project Plan Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Carl Wharton

    2009-10-01

    This report provides an evaluation of the Project Plan. The Project Plan is intended to provide the high-level direction that documents the required software activities to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  15. Review of the Tri-Agency Space Nuclear Reactor Power System Technology Program

    NASA Technical Reports Server (NTRS)

    Ambrus, J. H.; Wright, W. E.; Bunch, D. F.

    1984-01-01

    The Space Nuclear Reactor Power System Technology Program designated SP-100 was created in 1983 by NASA, the U.S. Department of Defense, and the Defense Advanced Research Projects Agency. Attention is presently given to the development history of SP-100 over the course of its first year, in which it has been engaged in program objectives' definition, the analysis of civil and military missions, nuclear power system functional requirements' definition, concept definition studies, the selection of primary concepts for technology feasibility validation, and the acquisition of initial experimental and analytical results.

  16. Special committee review of the Nuclear Regulatory Commission's severe accident risks report (NUREG--1150)

    SciTech Connect

    Kouts, H.J.C. ); Apostolakis, G.; Kastenberg, W.E. ); Birkhofer, E.H.A. , Koeln ); Hoegberg, L.G. ); LeSage, L.G. ); Rasmussen, N.C. (Massachusetts Inst. of Tech., Camb

    1990-08-01

    In April 1989, the Nuclear Regulatory Commission's (NRC) Office of Nuclear Regulatory Research (RES) published a draft report Severe Accident Risks: An Assessment for Five US Nuclear Power Plants,'' NUREG-1150. This report updated, extended and improved upon the information presented in the 1974 Reactor Safety Study,'' WASH-1400. Because the information in NUREG-1150 will play a significant role in implementing the NRC's Severe Accident Policy, its quality and credibility are of critical importance. Accordingly, the Commission requested that the RES conduct a peer review of NUREG-1150 to ensure that the methods, safety insights and conclusions presented are appropriate and adequately reflect the current state of knowledge with respect to reactor safety. To this end, RES formed a special committee in June of 1989 under the provisions of the Federal Advisory Committee Act. The Committee, composed of a group of recognized national and international experts in nuclear reactor safety, was charged with preparing a report reflecting their review of NUREG-1150 with respect to the adequacy of the methods, data, analysis and conclusions it set forth. The report which precedes reflects the results of this peer review.

  17. Report to the US Nuclear Regulatory Commission on Analysis and Evaluation of Operational Data, 1986

    SciTech Connect

    1987-05-01

    This annual report of the US Nuclear Regulatory Commission's Office for Analysis and Evaluation of Operational Data (AEOD) is devoted to the activities performed during calendar year 1986. Comments and observations are provided on operating experience at nuclear power plants and other NRC licensees, including results from selected AEOD studies; summaries of abnormal occurrences involving US nuclear plants; reviews of licensee event reports and their quality, reactor scram experience from 1984 to 1986, engineered safety features actuations, and the trends and patterns analysis program; and assessments of nonreactor and medical misadministration events. In addition, the report provides the year-end status of all recommendations included in AEOD studies, and listings of all AEOD reports issued from 1980 through 1986.

  18. 76 FR 78173 - Options for Developing the Regulatory Basis for Streamlining Non-Power Reactor License Renewal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ..., Division of Policy and Rulemaking, Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission... Regulatory Commission. Jessie F. Quichocho, Division of Policy and Rulemaking, Office of Nuclear Reactor...- Power Reactor License Renewal and Non-Power Reactor Emergency Preparedness AGENCY: Nuclear...

  19. Assistance to Oil and Gas State Agencies and Industry through Continuation of Environmental and Production Data Management and a Water Regulatory Initiative

    SciTech Connect

    Grunewald, Ben; Arthur, Dan; Langhus, Bruce; Gillespie, Tom; Binder, Ben; Warner, Don; Roberts, Jim; Cox, D.O.

    2002-05-31

    This grant project was a major step toward completion of the Risk Based Data Management System (RBDMS) project. Additionally the project addresses the needs identified during the projects initial phases. By implementing this project, the following outcomes were sought: (1) State regulatory agencies implemented more formalized environmental risk management practices as they pertain to the production of oil and gas, and injection via Class II wells. (2) Enhancement of oil and gas production by implementing a management system supporting the saving of abandoned or idle wells located in areas with a relatively low environmental risk of endangering underground sources of drinking water (USDWs) in a particular state. (3) Verification that protection of USDWs is adequate and additional restrictions of requirements are not necessary in areas with a relatively low environmental risk. (4) Standardization of data and information maintained by state regulatory agencies and decrease the regulatory cost burden on producers operating in multiple states, and (5) Development of a system for electronic data transfer among operators and state regulatory agencies and reduction of overall operator reporting burdens.

  20. 77 FR 40091 - Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating, Units 2 and 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating, Units 2 and 3 AGENCY: Nuclear... statement for license renewal of nuclear plants; availability. SUMMARY: The U.S. Nuclear...

  1. [Implementing new technology in radiation oncology: The French agency for nuclear safety (ASN) report].

    PubMed

    Lartigau, É-F; Lisbona, A; Isambert, A; Cadot, P; Derreumaux, S; Dupuis, O; Gérard, J-P; Ledu, D; Mahé, M-A; Marchesi, V; Mazurier, J; De Oliveira, A; Phare, O; Aubert, B

    2015-10-01

    In August 2013, the French nuclear safety agency (ASN) requested the permanent group of experts in radiation protection in medicine (GPMED) to propose recommendations on the implementation of new technology and techniques in radiation oncology. These recommendations were finalized in February 2015 by the GPMED. In April 2015, the ASN sent a letter to the French ministry of health (DGS/DGOS), and its national health agencies (ANSM, INCa, HAS). In these letters, ASN proposed that, from the 12 recommendations made by the GPMED, an action plan should be established, whose control could be assigned to the French national cancer institute (INCa), as a pilot of the national committee for radiotherapy and that this proposal has to be considered at the next meeting of the national committee of radiotherapy. PMID:26278991

  2. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    SciTech Connect

    Uleck, R.B.; DeFino, C.V.

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health and safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.

  3. The Defense Threat Reduction Agency's Technical Nuclear Forensics Research and Development Program

    NASA Astrophysics Data System (ADS)

    Franks, J.

    2015-12-01

    The Defense Threat Reduction Agency (DTRA) Technical Nuclear Forensics (TNF) Research and Development (R&D) Program's overarching goal is to design, develop, demonstrate, and transition advanced technologies and methodologies that improve the interagency operational capability to provide forensics conclusions after the detonation of a nuclear device. This goal is attained through the execution of three focus areas covering the span of the TNF process to enable strategic decision-making (attribution): Nuclear Forensic Materials Exploitation - Development of targeted technologies, methodologies and tools enabling the timely collection, analysis and interpretation of detonation materials.Prompt Nuclear Effects Exploitation - Improve ground-based capabilities to collect prompt nuclear device outputs and effects data for rapid, complementary and corroborative information.Nuclear Forensics Device Characterization - Development of a validated and verified capability to reverse model a nuclear device with high confidence from observables (e.g., prompt diagnostics, sample analysis, etc.) seen after an attack. This presentation will outline DTRA's TNF R&D strategy and current investments, with efforts focusing on: (1) introducing new technical data collection capabilities (e.g., ground-based prompt diagnostics sensor systems; innovative debris collection and analysis); (2) developing new TNF process paradigms and concepts of operations to decrease timelines and uncertainties, and increase results confidence; (3) enhanced validation and verification (V&V) of capabilities through technology evaluations and demonstrations; and (4) updated weapon output predictions to account for the modern threat environment. A key challenge to expanding these efforts to a global capability is the need for increased post-detonation TNF international cooperation, collaboration and peer reviews.

  4. Opinions and decisions of the Nuclear Regulatory Commission with selected orders, July 1, 1995--December 31, 1995. Volume 42, Pages 1-258

    SciTech Connect

    1996-11-01

    This is the 42nd volume of issuances of the U.S. Nuclear Regulatory Commission (NRC) and its Atomic Safety and Licensing Boards, Administrative Law Judges, and Office Directors. This book is a reprinting, containing corrections of numerous printing errors in a previously distributed book. It covers the period from July 1, 1995 to December 31, 1995. Atomic Safety and Licensing Boards conduct adjudicatory hearings on applications to construct and operate nuclear power plants and related facilities, and issue initial decisions which, subject to internal review and appellate procedures, become the final Commission action with respect to those applications. The hardbound edition of the Nuclear Regulatory Commission Issuances is a final compilation of the monthly issuances. It includes all of the legal precedents for the agency within a 6-month period. Any opinions, decisions, denials, memoranda and orders of the Commission inadvertently omitted from the monthly editions and any corrections submitted by the NRC legal staff to the printed softbound issuances are contained in the hardbound edition.

  5. State Regulatory Authority (SRA) Coordination of Safety, Security, and Safeguards of Nuclear Facilities: A Framework for Analysis

    SciTech Connect

    Mladineo, Stephen V.; Frazar, Sarah L.; Kurzrok, Andrew J.; Martikka, Elina; Hack, Tapani; Wiander, Timo

    2013-05-30

    This paper will explore the development of a framework for conducting an assessment of safety-security-safeguards integration within a State. The goal is to examine State regulatory structures to identify conflicts and gaps that hinder management of the three disciplines at nuclear facilities. Such an analysis could be performed by a State Regulatory Authority (SRA) to provide a self-assessment or as part of technical cooperation with either a newcomer State, or to a State with a fully developed SRA.

  6. Vital area identification for U.S. Nuclear Regulatory Commission nuclear power reactor licensees and new reactor applicants.

    SciTech Connect

    Whitehead, Donnie Wayne; Varnado, G. Bruce

    2008-09-01

    U.S. Nuclear Regulatory Commission nuclear power plant licensees and new reactor applicants are required to provide protection of their plants against radiological sabotage, including the placement of vital equipment in vital areas. This document describes a systematic process for the identification of the minimum set of areas that must be designated as vital areas in order to ensure that all radiological sabotage scenarios are prevented. Vital area identification involves the use of logic models to systematically identify all of the malicious acts or combinations of malicious acts that could lead to radiological sabotage. The models available in the plant probabilistic risk assessment and other safety analyses provide a great deal of the information and basic model structure needed for the sabotage logic model. Once the sabotage logic model is developed, the events (or malicious acts) in the model are replaced with the areas in which the events can be accomplished. This sabotage area logic model is then analyzed to identify the target sets (combinations of areas the adversary must visit to cause radiological sabotage) and the candidate vital area sets (combinations of areas that must be protected against adversary access to prevent radiological sabotage). Any one of the candidate vital area sets can be selected for protection. Appropriate selection criteria will allow the licensee or new reactor applicant to minimize the impacts of vital area protection measures on plant safety, cost, operations, or other factors of concern.

  7. Upgrading of data acquisition software for centralized radiation monitoring system in Malaysian Nuclear Agency

    NASA Astrophysics Data System (ADS)

    Yussup, F.; Ibrahim, M. M.; Haris, M. F.; Soh, S. C.; Hasim, H.; Azman, A.; Razalim, F. A. A.; Yapp, R.; Ramli, A. A. M.

    2016-01-01

    With the growth of technology, many devices and equipments can be connected to the network and internet to enable online data acquisition for real-time data monitoring and control from monitoring devices located at remote sites. Centralized radiation monitoring system (CRMS) is a system that enables area radiation level at various locations in Malaysian Nuclear Agency (Nuklear Malaysia) to be monitored centrally by using a web browser. The Local Area Network (LAN) in Nuclear Malaysia is utilized in CRMS as a communication media for data acquisition of the area radiation levels from radiation detectors. The development of the system involves device configuration, wiring, network and hardware installation, software and web development. This paper describes the software upgrading on the system server that is responsible to acquire and record the area radiation readings from the detectors. The recorded readings are called in a web programming to be displayed on a website. Besides the main feature which is acquiring the area radiation levels in Nuclear Malaysia centrally, the upgrading involves new features such as uniform time interval for data recording and exporting, warning system and dose triggering.

  8. Cotyledon nuclear proteins bind to DNA fragments harboring regulatory elements of phytohemagglutinin genes.

    PubMed Central

    Riggs, C D; Voelker, T A; Chrispeels, M J

    1989-01-01

    The effects of deleting DNA sequences upstream from the phytohemagglutinin-L gene of Phaseolus vulgaris have been examined with respect to the level of gene product produced in the seeds of transgenic tobacco. Our studies indicate that several upstream regions quantitatively modulate expression. Between -1000 and -675, a negative regulatory element reduces expression approximately threefold relative to shorter deletion mutants that do not contain this region. Positive regulatory elements lie between -550 and -125 and, compared with constructs containing only 125 base pairs of upstream sequences (-125), the presence of these two regions can be correlated with a 25-fold and a 200-fold enhancement of phytohemagglutinin-L levels. These experiments were complemented by gel retardation assays, which demonstrated that two of the three regions bind cotyledon nuclear proteins from mid-mature seeds. One of the binding sites maps near a DNA sequence that is highly homologous to protein binding domains located upstream from the soybean seed lectin and Kunitz trypsin inhibitor genes. Competition experiments demonstrated that the upstream regions of a bean beta-phaseolin gene, the soybean seed lectin gene, and an oligonucleotide from the upstream region of the trypsin inhibitor gene can compete differentially for factor binding. We suggest that these legume genes may be regulated in part by evolutionarily conserved protein/DNA interactions. PMID:2535513

  9. Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain

    PubMed Central

    Halmai, Miklos; Frittmann, Orsolya; Szabo, Zoltan; Daraba, Andreea; Gali, Vamsi K.; Balint, Eva; Unk, Ildiko

    2016-01-01

    Proliferating cell nuclear antigen (PCNA) plays a key role in many cellular processes and due to that it interacts with a plethora of proteins. The main interacting surfaces of Saccharomyces cerevisiae PCNA have been mapped to the interdomain connecting loop and to the carboxy-terminal domain. Here we report that the subunit interface of yeast PCNA also has regulatory roles in the function of several DNA damage response pathways. Using site-directed mutagenesis we engineered mutations at both sides of the interface and investigated the effect of these alleles on DNA damage response. Genetic experiments with strains bearing the mutant alleles revealed that mutagenic translesion synthesis, nucleotide excision repair, and homologous recombination are all regulated through residues at the subunit interface. Moreover, genetic characterization of one of our mutants identifies a new sub-branch of nucleotide excision repair. Based on these results we conclude that residues at the subunit boundary of PCNA are not only important for the formation of the trimer structure of PCNA, but they constitute a regulatory protein domain that mediates different DNA damage response pathways, as well. PMID:27537501

  10. 2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 2 - hybrid LBA/LCMS and input from regulatory agencies).

    PubMed

    Ackermann, Brad; Neubert, Hendrik; Hughes, Nicola; Garofolo, Fabio; Abberley, Lee; Alley, Stephen C; Brown-Augsburger, Patricia; Bustard, Mark; Chen, Lin-Zhi; Heinrich, Julia; Katori, Noriko; Kaur, Surinder; Kirkovsky, Leo; Laterza, Omar F; Le Blaye, Olivier; Lévesque, Ann; Santos, Gustavo Mendes Lima; Olah, Timothy; Savoie, Natasha; Skelly, Michael; Spitz, Susan; Szapacs, Matthew; Tampal, Nilufer; Wang, Jian; Welink, Jan; Wieling, Jaap; Haidar, Sam; Vinter, Stephen; Whale, Emma; Witte, Bärbel

    2015-12-01

    The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami, Florida with participation of over 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. It is once again a 5-day week long event - a full immersion bioanalytical week - specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS, LBA approaches including the focus on biomarkers and immunogenicity. This 2015 White Paper encompasses recommendations that emerged from the extensive discussions held during the workshop, and is aimed at providing the bioanalytical community with key information and practical solutions on topics and issues addressed, in an effort to advance scientific excellence, improve quality and deliver better regulatory compliance. Due to its length, the 2015 edition of this comprehensive White Paper has been divided into three parts. Part 2 covers the recommendations for hybrid LBA/LCMS and regulatory agencies' inputs. Part 1 (small molecule bioanalysis using LCMS) and Part 3 (large molecule bioanalysis using LBA, biomarkers and immunogenicity) will be published in volume 7 of Bioanalysis, issues 22 and 24, respectively. PMID:26627049

  11. 2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 2 - hybrid LBA/LCMS, ELN & regulatory agencies' input).

    PubMed

    Dufield, Dawn; Neubert, Hendrik; Garofolo, Fabio; Kirkovsky, Leo; Stevenson, Lauren; Dumont, Isabelle; Kaur, Surinder; Xu, Keyang; Alley, Stephen C; Szapacs, Matthew; Arnold, Mark; Bansal, Surendra; Haidar, Sam; Welink, Jan; Le Blaye, Olivier; Wakelin-Smith, Jason; Whale, Emma; Ishii-Watabe, Akiko; Bustard, Mark; Katori, Noriko; Amaravadi, Lakshmi; Aubry, Anne-Françoise; Beaver, Chris; Bergeron, Annik; Cai, Xiao-Yan; Cojocaru, Laura; DeSilva, Binodh; Duggan, Jeff; Fluhler, Eric; Gorovits, Boris; Gupta, Swati; Hayes, Roger; Ho, Stacy; Ingelse, Benno; King, Lindsay; Lévesque, Ann; Lowes, Steve; Ma, Mark; Musuku, Adrien; Myler, Heather; Olah, Timothy; Patel, Shefali; Rose, Mark; Schultz, Gary; Smeraglia, John; Swanson, Steven; Torri, Albert; Vazvaei, Faye; Wilson, Amanda; Woolf, Eric; Xue, Li; Yang, Tong-Yuan

    2014-01-01

    The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion in the evolving field of bioanalysis, took place in Universal City, California, USA. Close to 500 professionals from pharmaceutical and biopharmaceutical companies, contract research organizations and regulatory agencies worldwide convened to share, review, discuss and agree on approaches to address current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS, LBA approaches and immunogenicity. From the prolific discussions held during the workshop, specific recommendations are presented in this 2014 White Paper. As with the previous years' editions, this paper acts as a practical tool to help the bioanalytical community continue advances in scientific excellence, improved quality and better regulatory compliance. Due to its length, the 2014 edition of this comprehensive White Paper has been divided into three parts for editorial reasons. This publication (Part 2) covers the recommendations for Hybrid LBA/LCMS, Electronic Laboratory Notebook and Regulatory Agencies' Input. Part 1 (Small molecules bioanalysis using LCMS) was published in the Bioanalysis issue 6(22) and Part 3 (Large molecules bioanalysis using LBA and Immunogenicity) will be published in the Bioanalysis issue 6(24). PMID:25529890

  12. Nuclear medicine in the management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA)

    PubMed Central

    Peix, Amalia; Mesquita, Claudio Tinoco; Paez, Diana; Pereira, Carlos Cunha; Felix, Renata; Gutierrez, Claudia; Jaimovich, Rodrigo; Ianni, Barbara Maria; Soares, Jose; Olaya, Pastor; Rodriguez, Ma. Victoria; Flotats, Albert; Giubbini, Raffaele; Travin, Mark

    2014-01-01

    Heart failure is increasing worldwide at epidemic proportions, resulting in considerable disability, mortality, and increase in healthcare costs. Gated myocardial perfusion single photon emission computed tomography or PET imaging is the most prominent imaging modality capable of providing information on global and regional ventricular function, the presence of intraventricular synchronism, myocardial perfusion, and viability on the same test. In addition, 123I-mIBG scintigraphy is the only imaging technique approved by various regulatory agencies able to provide information regarding the adrenergic function of the heart. Therefore, both myocardial perfusion and adrenergic imaging are useful tools in the workup and management of heart failure patients. This guide is intended to reinforce the information on the use of nuclear cardiology techniques for the assessment of heart failure and associated myocardial disease. PMID:24781009

  13. Nuclear medicine in the management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA).

    PubMed

    Peix, Amalia; Mesquita, Claudio Tinoco; Paez, Diana; Pereira, Carlos Cunha; Felix, Renata; Gutierrez, Claudia; Jaimovich, Rodrigo; Ianni, Barbara Maria; Soares, Jose; Olaya, Pastor; Rodriguez, Ma Victoria; Flotats, Albert; Giubbini, Raffaele; Travin, Mark; Garcia, Ernest V

    2014-08-01

    Heart failure is increasing worldwide at epidemic proportions, resulting in considerable disability, mortality, and increase in healthcare costs. Gated myocardial perfusion single photon emission computed tomography or PET imaging is the most prominent imaging modality capable of providing information on global and regional ventricular function, the presence of intraventricular synchronism, myocardial perfusion, and viability on the same test. In addition, I-mIBG scintigraphy is the only imaging technique approved by various regulatory agencies able to provide information regarding the adrenergic function of the heart. Therefore, both myocardial perfusion and adrenergic imaging are useful tools in the workup and management of heart failure patients. This guide is intended to reinforce the information on the use of nuclear cardiology techniques for the assessment of heart failure and associated myocardial disease. PMID:24781009

  14. Review of DNA(Defense Nuclear Agency) Remote Security Station (RSS) Project. Phase 1

    SciTech Connect

    Pletta, J.B.; Workhoven, R.M.

    1988-08-01

    This report reviews the progress made during FY87 on the Defense Nuclear Agency (DNA) sponsored Remote Security Station (RSS). During this time frame, Sandia National Laboratories was tasked to develop a Phase 1 proof-of-principle system consisting of readily available hardware. The primary emphasis was placed upon development of software and sensor fusion techniques and, as a result, the Phase 1 hardware is not suitable for field deployment. The RSS consists of a portable (non-mobile) sensor platform and an intelligent controller. The paper includes descriptions of the sensor platform and control console hardware, as well as the software that runs the intelligent controller. The sensor fusion techniques originally considered are discussed, and the methods used in the current system are explained in detail. Phase 2 development of the RSS is scheduled for FY88, and a discussion of the planned improvements is included.

  15. Safety team assessments at NRC (Nuclear Regulatory Commission)-licensed fuel facilities

    SciTech Connect

    Sjoblom, G.L.

    1988-01-01

    Following the hydraulic rupture of a UF cylinder at the Sequoyah Fuels Facility on January 4, 1986, the US Nuclear Regulatory Commission's (NRC's) executive director for operations (EDO) established an augmented inspection team to investigate the accident. The investigation is reported in NUREG-1179. The EDO then formed a lessons-learned group to report on the action NRC might reasonably take to prevent similar accidents. The group's recommendations are reported in NUREG-1198. In addition, the EDO formed an independent materials safety regulation review study group (MSRRSG) to review the licensing and inspection program for NRC-licensed fuel cycle and materials facilities. During the same period of time that the MSRRSG report was being prepared and evaluated, the staff undertook an independent action to assess operational safety at each of the 12 major fuel facilities licensed by the NRC. The facilities included the 2 facilities producing uranium hexafluoride, the 7 facilities producing commercial nuclear reactor fuel, and the 3 facilities producing naval reactor fuel. The most important safety issues identified as needing attention by licensees were in the areas of fire protection, chemical hazards identification and mitigation, management controls or quality assurance, safety-related instrumentation and maintenance, and emergency preparedness.

  16. Independent Verification and Validation Of SAPHIRE 8 Risk Management Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Kent Norris

    2009-11-01

    This report provides an evaluation of the risk management. Risk management is intended to ensure a methodology for conducting risk management planning, identification, analysis, responses, and monitoring and control activities associated with the SAPHIRE project work, and to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  17. 77 FR 6131 - Memorandum of Understanding Between the U.S. Nuclear Regulatory Commission and the Department of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... the location of the proposed facility to terrorist attack. II. Background Nuclear Regulatory... application, the NRC addresses potential vulnerabilities of the location of the proposed facility to terrorist... to secure America by preventing, deterring, and responding to terrorist attacks and other ]...

  18. 78 FR 13712 - U.S. Nuclear Regulatory Commission Planned Monitoring Activities for F-Area Tank Farm at the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... COMMISSION U.S. Nuclear Regulatory Commission Planned Monitoring Activities for F-Area Tank Farm at the... Savannah River Site F-Area Tank Farm Facility in Accordance with the National Defense Authorization Act for... DOE's waste disposal activities at the F-Area Tank Farm at the Savannah River Site, in accordance...

  19. 75 FR 25301 - Nuclear Fuel Services, Inc.; Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... implement NRC-approved radiation safety procedures for storing and handling radioactive materials. Thus, the... Proposed Extension of Deadline for Inventory of Special Nuclear Material AGENCY: Nuclear Regulatory... Safeguards, Office of Nuclear Material Safety and Safeguards, U.S. Nuclear Regulatory Commission, Mail...

  20. 78 FR 35330 - Initial Test Programs for Water-Cooled Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... COMMISSION Initial Test Programs for Water-Cooled Nuclear Power Plants AGENCY: Nuclear Regulatory Commission... revision to Regulatory Guide (RG), 1.68, ``Initial Test Programs for Water-Cooled Nuclear Power Plants... Initial Test Programs (ITPs) for light water cooled nuclear power plants. ADDRESSES: Please refer...

  1. 78 FR 64028 - Decommissioning of Nuclear Power Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Register on February 14, 2012 (77 FR 8902), for a 60-day public comment period. The public comment period... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Decommissioning of Nuclear Power Reactors AGENCY: Nuclear Regulatory Commission....

  2. 77 FR 18271 - Terrestrial Environmental Studies for Nuclear Power Stations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... decommissioning. II. Further Information DG-4016, was published in the Federal Register on August 12, 2011 (76 FR... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Terrestrial Environmental Studies for Nuclear Power Stations AGENCY: Nuclear Regulatory...

  3. 10 CFR 15.20 - Aggressive agency collection activity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Aggressive agency collection activity. 15.20 Section 15.20 Energy NUCLEAR REGULATORY COMMISSION DEBT COLLECTION PROCEDURES Administrative Collection of Claims § 15.20 Aggressive agency collection activity. (a) The NRC shall take aggressive action to collect...

  4. 48 CFR 2033.103 - Protests to the agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Protests to the agency. 2033.103 Section 2033.103 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Protests 2033.103 Protests to the agency. Protests...

  5. 10 CFR 76.53 - Consultation with Environmental Protection Agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Consultation with Environmental Protection Agency. 76.53 Section 76.53 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.53 Consultation with Environmental Protection Agency. In reviewing an application for...

  6. 29 CFR 24.108 - Role of Federal agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Labor. (b) The Environmental Protection Agency, the Nuclear Regulatory Commission, and the... PROTECTION PROVISIONS OF SIX ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974... 29 Labor 1 2011-07-01 2011-07-01 false Role of Federal agencies. 24.108 Section 24.108...

  7. 29 CFR 24.108 - Role of Federal agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Labor. (b) The Environmental Protection Agency, the Nuclear Regulatory Commission, and the... PROTECTION PROVISIONS OF SIX ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974... 29 Labor 1 2013-07-01 2013-07-01 false Role of Federal agencies. 24.108 Section 24.108...

  8. 29 CFR 24.108 - Role of Federal agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Labor. (b) The Environmental Protection Agency, the Nuclear Regulatory Commission, and the... PROTECTION PROVISIONS OF SIX ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974... 29 Labor 1 2014-07-01 2013-07-01 true Role of Federal agencies. 24.108 Section 24.108 Labor...

  9. Nuclear fuel, refueling, fuel handling, and licensing and regulation. Volume eleven

    SciTech Connect

    Not Available

    1986-01-01

    Volume eleven covers nuclear fuel (what is nuclear fuel, the nuclear fuel cycle, uranium mining, milling, and refining, uranium enrichment, nuclear fuel fabrication, fuel reprocessing), refueling and fuel handling (fuel assembly identification, fuel handling equipment, the fueling and refueling process, PWR refueling, BWR refueling), and licensing and regulation requirements (development of nuclear energy, federal licensing and regulatory organization, schedule for nuclear power plants, contents of reports to the Federal regulatory agency, nuclear power plant operator qualification).

  10. Application of risk-based methods to optimize inspection planning for regulatory activities at nuclear power plants

    SciTech Connect

    Wong, S.M.; Higgins, J.C.; Martinez-Guridi, G.

    1995-07-01

    As part of regulatory oversight requirements, the U.S. Nuclear Regulatory Commission (USNRC) staff conducts inspection activities to assess operational safety performance in nuclear power plants. Currently, guidance in these inspections is provided by procedures in the NRC Inspection Manual and issuance of Temporary Instructions defining the objectives and scope of the inspection effort. In several studies sponsored by the USNRC over the last few years, Brookhaven National Laboratory (BNL) has developed and applied methodologies for providing risk-based inspection guidance for the safety assessments of nuclear power plant systems. One recent methodology integrates insights from existing Probabilistic Risk Assessment (PRA) studies and Individual Plant Evaluations (TPE) with information from operating experience reviews for consideration in inspection planning for either multi-disciplinary team inspections or individual inspections. In recent studies at BNL, a risk-based methodology was developed to optimize inspection planning for regulatory activities at nuclear power plants. This methodology integrates risk-based insights from the plant configuration risk profile and risk information found in existing PRA/IPE studies.

  11. USING TECHNOLOGY TO SUPPORT PROACTIVE MANAGEMENT OF MATERIALS DEGRADATION FOR THE U.S. NUCLEAR REGULATORY COMMISSION

    SciTech Connect

    Taylor, W Boyd; Knobbs, Katherine J.; Carpenter, C. E.; Malik, Shah

    2010-07-19

    The majority of the U.S. reactor fleet is applying for license renewal to extend the operating life from the current 40 years to 60 years, and there is now active interest in extending the operating life to beyond 60 years. Many plants are also applying for increases in power rating and both of these changes increases the need for an improved understanding of materials degradation. Many materials degrade over time and much is known about the degradation of materials under normal environmental conditions; however, less is known about the characteristics of materials degradation when the environment is subject to higher than normal radiological conditions over extended periods of time. Significant efforts are being made by industrial, academic and regulatory groups worldwide to identify, classify and mitigate potential problems arising from degradation of components in this context. From a regulatory perspective, the U.S. Nuclear Regulatory Commission (USNRC) is very interested in being able to identify ways to insure their licensees proactively manage the identification of materials degradation and the mitigation of its effects. To date, the USNRC has consolidated “generic” programs for mitigating aging issues in the two volume Generic Aging Lessons Learned (GALL) Report (NUREG-1801) [1][2], and have encouraged applicants for license renewal to use these programs where applicable in their plant when applying for renew of their reactor’s license. The USNRC has also published a comprehensive report entitled Expert Panel Report on Proactive Materials Degradation (NUREG/CR-6923) [3] that inventories the types of degradation mechanisms that could exist in each component of a Light Water Reactor (LWR) and each degradation mechanism is assessed regarding how much is known about mitigating its effects. Since the number of plant designs and materials used varies greatly within the U.S. fleet, there are many variations to implementing aging management programs (AMPs

  12. DNA Radiation Environments Program Spring 1991 2-meter box experiments and analyses. [DEfense Nuclear Agency (DNA)

    SciTech Connect

    Santoro, R.T. ); Whitaker, S.Y. )

    1993-03-01

    This report summarizes the Spring 1991 2-m Box experiments that were performed at the Army Pulse Radiation Facility (APRF) at Aberdeen Proving Ground. These studies were sponsored by the Defense Nuclear Agency (DNA) under the Radiation Environments Program to obtain measured data for benchmarking the Adjoint Monte Carlo Code System, MASH, Version 1.0. The MASH code system was developed for the Department of Defense and NATO for calculating neutron and gamma-ray radiation fields and shielding protection factors for armored vehicles and military structures against nuclear weapon radiation. In the 2-m Box experiments, neutron and gamma-ray dose rates and reduction factors were measured in the free-field and as a function of position on an anthropomorphic phantom that was placed outside and inside a borated polyethylene lined steel-walled 2-m box. The data were acquired at a distance of 400-m from the APRF reactor. The purpose of these experiments was to measure the neutron and gamma-ray dose rates as a function of detector location on the phantom for cases when the phantom was in the free-field and inside of the box. Neutron measurements were made using a BD-100R bubble detector and gamma-ray measurements were made using thermoluminescent detectors (TLD). Calculated and measured data were compared in terms of the C/M ratio. The calculated and measured neutron and gamma-ray dose rates and reduction factors agreed on the average within the [plus minus]20% limits mandated by DNA and demonstrate the capability of the MASH code system in reproducing measured data in nominally shielded assemblies.

  13. MC21 analysis of the nuclear energy agency Monte Carlo performance benchmark problem

    SciTech Connect

    Kelly, D. J.; Sutton, T. M.; Wilson, S. C.

    2012-07-01

    Due to the steadily decreasing cost and wider availability of large scale computing platforms, there is growing interest in the prospects for the use of Monte Carlo for reactor design calculations that are currently performed using few-group diffusion theory or other low-order methods. To facilitate the monitoring of the progress being made toward the goal of practical full-core reactor design calculations using Monte Carlo, a performance benchmark has been developed and made available through the Nuclear Energy Agency. A first analysis of this benchmark using the MC21 Monte Carlo code was reported on in 2010, and several practical difficulties were highlighted. In this paper, a newer version of MC21 that addresses some of these difficulties has been applied to the benchmark. In particular, the confidence-interval-determination method has been improved to eliminate source correlation bias, and a fission-source-weighting method has been implemented to provide a more uniform distribution of statistical uncertainties. In addition, the Forward-Weighted, Consistent-Adjoint-Driven Importance Sampling methodology has been applied to the benchmark problem. Results of several analyses using these methods are presented, as well as results from a very large calculation with statistical uncertainties that approach what is needed for design applications. (authors)

  14. Results of regulatory impact survey of industrial and medical materials licensees of the Office of Nuclear Material Safety and Safeguards

    SciTech Connect

    Lach, D.; Melber, B.; Brichoux, J.; Hattrup, M.; Conger, R.; Hughes, K.

    1995-06-01

    This report presents the findings of a regulatory impact survey of nuclear materials licensees of the United States Nuclear Regulatory Commission (NRC). Commissioners of the NRC directed staff to provide the Commission with first hand information from licensees that could be used to improve the overall regulatory program. A self-administered, mail-out survey questionnaire was used to collect data from a sample of licensees who had interaction with the NRC during the previous 12 months. A total of 371 respondents of the 589 who were sent questionnaires returned completed surveys, for a response rate of 63%. The body of the report presents the findings of the survey including a brief introduction to the approach used, followed by survey findings regarding regulations, policies and regulatory guidance; experience with licensing applications, renewals and amendments; inspections; reporting requirements; and enforcement actions. The appendices of the report include a copy of the survey as administered to licensees, a fuller description of the survey design and data collection methods, and detailed graphic material describing survey responses.

  15. Management of National Nuclear Power Programs for assured safety

    SciTech Connect

    Connolly, T.J.

    1985-01-01

    Topics discussed in this report include: nuclear utility organization; before the Florida Public Service Commission in re: St. Lucie Unit No. 2 cost recovery; nuclear reliability improvement and safety operations; nuclear utility management; training of nuclear facility personnel; US experience in key areas of nuclear safety; the US Nuclear Regulatory Commission - function and process; regulatory considerations of the risk of nuclear power plants; overview of the processes of reliability and risk management; management significance of risk analysis; international and domestic institutional issues for peaceful nuclear uses; the role of the Institute of Nuclear Power Operations (INPO); and nuclear safety activities of the International Atomic Energy Agency (IAEA).

  16. A safety and regulatory assessment of generic BWR and PWR permanently shutdown nuclear power plants

    SciTech Connect

    Travis, R.J.; Davis, R.E.; Grove, E.J.; Azarm, M.A.

    1997-08-01

    The long-term availability of less expensive power and the increasing plant modification and maintenance costs have caused some utilities to re-examine the economics of nuclear power. As a result, several utilities have opted to permanently shutdown their plants. Each licensee of these permanently shutdown (PSD) plants has submitted plant-specific exemption requests for those regulations that they believe are no longer applicable to their facility. This report presents a regulatory assessment for generic BWR and PWR plants that have permanently ceased operation in support of NRC rulemaking activities in this area. After the reactor vessel is defueled, the traditional accident sequences that dominate the operating plant risk are no longer applicable. The remaining source of public risk is associated with the accidents that involve the spent fuel. Previous studies have indicated that complete spent fuel pool drainage is an accident of potential concern. Certain combinations of spent fuel storage configurations and decay times, could cause freshly discharged fuel assemblies to self heat to a temperature where the self sustained oxidation of the zircaloy fuel cladding may cause cladding failure. This study has defined four spent fuel configurations which encompass all of the anticipated spent fuel characteristics and storage modes following permanent shutdown. A representative accident sequence was chosen for each configuration. Consequence analyses were performed using these sequences to estimate onsite and boundary doses, population doses and economic costs. A list of candidate regulations was identified from a screening of 10 CFR Parts 0 to 199. The continued applicability of each regulation was assessed within the context of each spent fuel storage configuration and the results of the consequence analyses.

  17. Mission impossible? - Government Agencies And Public Relations For Nuclear Waste Disposal In Germany

    SciTech Connect

    Landsmann, B.; Brauer, V.

    2007-07-01

    Analyzing the opinion of European Union citizens on the management of radioactive waste a survey of 2005 shows that European citizens are almost unanimous in the need to set up a national strategy for high-level radioactive waste disposal without any delay. While 45% of respondents consider that deep underground disposal represents the most appropriate solution for long-term management of highly radioactive waste, 38% disagree. In Germany, the divergence of opinion in this respect is very distinctive and it shows that, although experts believe that selected sites represent the best solution, this information does not yet seem to have reached the public. The reason therefore is both the lack of interesting and comprehensible information of issues related to nuclear waste disposal and negative media reporting always coupled with the negative public opinion about atomic energy in Germany. In Germany the siting, construction, and operation of a repository for radioactive waste is a national task. The Federal Institute for Geosciences and Natural Resources (BGR) as a government agency is a praxis oriented science institution and works on all geo-scientific and geotechnical issues in the German repository projects. According to its guidance BGR feels responsible for the future generations and is acting as a neutral and anticipatory partner for ministries and public authorities as well as a partner for industry, society and scientific bodies. BGR therefore is able to accomplish an essential contribution for the creation of public confidence for radioactive waste disposal due to precise public relations strategies. Sending the following messages is BGR's communication goal: - Radioactive waste can safely be disposed of in deep geological formations; - BGR is capable to handle this duty and delivers reliable results. Thereby, the BGR is in particular interested in passing on the information about nuclear waste disposal in a current and comprehensible way as well as

  18. Qualification opinion of novel methodologies in the predementia stage of Alzheimer's disease: cerebro-spinal-fluid related biomarkers for drugs affecting amyloid burden--regulatory considerations by European Medicines Agency focusing in improving benefit/risk in regulatory trials.

    PubMed

    Isaac, Maria; Vamvakas, Spiros; Abadie, Eric; Jonsson, Bertil; Gispen, Christine; Pani, Luca

    2011-11-01

    The European Medicines Agency (EMA) in London is responsible for the Regulatory review of new medicinal products for Marketing Authorisation, through which pharmaceutical companies may obtain first Marketing Authorisation and subsequent Variations valid throughout the EU and EFTA. The qualification opinion of novel methodologies is a new procedure where applicants can obtain scientific advice on new methodologies for regulatory clinical trials of efficacy of new compounds. It will help benefit/risk assessment of the CHMP. The definition of prodromal AD is acceptable. The "Dubois Criteria" as criteria to define the population must be validated in full at the time of the submission of the dossiers. Including a positive CSF biomarker profile is considered predictive for the evaluation of the AD-dementia type. However, although high CSF tau and low CSF Aβ42 are predictive of Alzheimer's disease, the criterion "positive CSF tau/Aβ42 ratio" is not well defined. The qualification of biomarkers in the pre-dementia stage of Alzheimer's disease will allow better inclusion criteria of patients in pre-dementia trials in which the benefit/risk is higher for treatment with these novel compounds. PMID:21903360

  19. 77 FR 27804 - Entergy Operations, Inc.; Grand Gulf Nuclear Station, Unit 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Operations, Inc.; Grand Gulf Nuclear Station, Unit 1 AGENCY: Nuclear Regulatory Commission. ACTION: Draft environmental assessment and finding of no significant impact, opportunity to comment. DATES: Comments must be filed by June 11,...

  20. 77 FR 50533 - Dominion Nuclear Connecticut, Inc.; Millstone Power Station, Unit 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Dominion Nuclear Connecticut, Inc.; Millstone Power Station, Unit 3 AGENCY: Nuclear Regulatory Commission. ACTION: Environmental assessment and finding of no significant impact; issuance. ADDRESSES: Please refer to Docket ID NRC-2012-0197...

  1. 77 FR 1743 - Facility Operating License Amendment From Florida Power Corporation, Crystal River Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Facility Operating License Amendment From Florida Power Corporation, Crystal River Nuclear Generating Plant, Unit 3 AGENCY: Nuclear Regulatory Commission. ACTION: License amendment; opportunity to request a hearing, petition for leave to...

  2. The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory Agency Approved Drug

    PubMed Central

    Johnson, Steven M.; Connelly, Stephen; Fearns, Colleen; Powers, Evan T.; Kelly, Jeffery W.

    2012-01-01

    Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (i.e., undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous system and/or heart pathology. While several of these maladies are associated with mutations that destabilize the TTR native quaternary and/or tertiary structure, wild type TTR amyloidogenesis also leads to the degeneration of post-mitotic tissue. Over the past twenty years, much has been learned about the factors that influence the propensity of TTR to aggregate. This biophysical information led to the development of a therapeutic strategy, termed “kinetic stabilization”, to prevent TTR amyloidogenesis. This strategy afforded the drug, tafamidis (trade name: Vyndaqel®), which was recently approved by the European Medicines Agency for the treatment of Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP), a common familial TTR amyloid disease. Tafamidis is the first, and currently the only, medication approved to treat TTR-FAP. Here we review the biophysical basis for the kinetic stabilization strategy and the structure-based drug design effort that led to this first-in-class pharmacologic agent. PMID:22244854

  3. Incorporation of Risk Insights in the Regulatory Treatment of Nuclear Power Plant Structures,Systems,and Components

    SciTech Connect

    Imbro, Eugene; Scarbrough, Thomas G.

    2002-07-01

    The U.S. Nuclear Regulatory Commission (NRC) has established an initiative to risk-inform the requirements in Title 10 of the Code of Federal Regulations (10 CFR) for the regulatory treatment of structures, systems, and components (SSCs) used in commercial nuclear power plants. As discussed in several Commission papers (e.g., SECY-99-256 and SECY-00-0194), Option 2 of this initiative involves categorizing plant SSCs based on their safety significance, and specifying treatment that would provide an appropriate level of confidence in the capability of those SSCs to perform their design functions in accordance with their risk categorization. The NRC has initiated a rulemaking effort to allow licensees of nuclear power plants in the United States to implement the Option 2 approach in lieu of the 'special treatment requirements' of the NRC regulations. In a proof-of-concept effort, the NRC recently granted exemptions from the special treatment requirements for safety-related SSCs categorized as having low risk significance by the licensee of the South Texas Project (STP) Units 1 and 2 nuclear power plant, based on a review of the licensee's high-level objectives of the planned treatment for safety-related and high-risk non-safety-related SSCs. This paper discusses the NRC staff's views regarding the treatment of SSCs at STP described by the licensee in its updated Final Safety Analysis Report (FSAR) in support of the exemption request, and provides the status of rulemaking that would incorporate risk insights into the treatment of SSCs at nuclear power plants. (authors)

  4. 76 FR 43731 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB... Regulatory Affairs (3150-0131), NEOB-10202, Office of Management and Budget, Washington, DC 20503....

  5. Nuclear Regulatory Commission inspection program and the Oyster Creek, N. J. , nuclear facility. Hearings before a subcommittee of the Committee on Government Operations, House of Representatives, Ninety-sixth Congress, Second Session

    SciTech Connect

    Not Available

    1980-01-01

    A congressional hearing was held May 28, 1980 by the Environment, Energy and Natural Resources Subcommittee of the Committee on Government Operations to discuss the Nuclear Regulatory Commission Inspection Program and the Oyster Creek Nuclear Power Plant. This discussion included an explanation of the responsibilities now facing the Nuclear Regulatory Commission, particularly the insurance that the 68 operating nuclear power reactors are operated safely and completely by licensees with sound management practices. In addition, an explanation was given of the emergency shutdown of Oyster Creek-1 Reactor.

  6. [Cancer: Is it really so different? Particularities of oncologic drugs from the perspective of the pharmaceutical regulatory agency].

    PubMed

    Enzmann, Harald; Broich, Karl

    2013-01-01

    For innovative oncological medicines the centralised procedure at the European Medicines Agency is mandatory for a marketing authorisation application for the European Union. As with other medical drugs, the marketing authorisation decision is based on the assessment of its efficacy, safety and pharmaceutical quality but does not consider price or reimbursement. More sophisticated diagnostic methods drive an increasing stratification of cancer into a multitude of different diseases. Regardless of their different pathogenesis and therapeutic options the most relevant clinical endpoints remain cure, overall survival and progression free survival. These endpoints include both efficacy and safety, as patient survival reflects the sum of the beneficial anti-tumour effects (increasing survival) AND the adverse effects (decreasing survival). The benefit of an anticancer medicine should be evident from both overall survival and progression free survival (e.g. used as primary and secondary endpoints). Mature data on overall survival may not be needed for marketing authorisation if a clear increase in progression free survival convincingly predicts a beneficial effect on overall survival. In these exceptional cases treatment of patients with an obviously beneficial medicine must not be delayed - possibly for years - until the exact size of the benefit has been established. The continued stratification of the disease cancer results in a lower prevalence for each of the newly distinguished disease entities and an ever increasing number of orphan designations for medicines for rare diseases. Incentives for the development of orphan medicines include market exclusivity for up to ten years. In specific circumstances, however, the orphan legislation may restrict the authorisation and marketing of competing generic products even beyond these ten years. Conditional approval and approval under exceptional circumstances may accelerate patients' access to a new medicine. Both postulate

  7. 77 FR 33253 - Regulatory Guide 8.33, Quality Management Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...,'' published on November 4, 1991 (56 FR 56425). The guide provided guidance for licensees and applicants for... 67 FR 20370). Therefore, the guidance provided in RG 8.33 is neither necessary nor current. NUREG... COMMISSION Regulatory Guide 8.33, Quality Management Program AGENCY: Nuclear Regulatory Commission....

  8. Slovak Nuclear Regulatory Body Position in the Transport of Radioactive Waste

    SciTech Connect

    Homola, J.

    2003-02-27

    This paper describes safety requirements for transport of radioactive waste in Slovakia and the role of regulatory body in the transport licensing and assessment processes. Importance of radioactive waste shipments have been increased since 1999 by starting of NPP A-1 decommissioning and operation of near surface disposal facility. Also some information from history of shipment as well as future activities are given. Legal basis for radioactive waste transport is resulting from IAEA recommendations in this area. Different types of transport equipment were approved by regulatory body for both liquid and solid waste and transportation permits were issued to their shipment. Regulatory body attention during evaluation of transport safety is focused mainly on ability of individual packages to withstand different transport conditions and on safety analyses performed for transport equipment for liquid waste with high frequency of shipments. During past three years no event was occurred in connection with radioactive waste transport in Slovakia.

  9. Report to the US Nuclear Regulatory Commission on analysis and evaluation of operational data - 1987: Power reactors

    SciTech Connect

    1988-10-01

    This annual report of the US Nuclear Regulatory Commission's Office for Analysis and Evaluation of Operational Data (AEOD) is devoted to the activities performed during 1987. The report is published in two volumes. NUREG-1272, Vol. 2, No. 1, covers Power Reactors and presents an overview of the operating experience of the nuclear power industry, with comments regarding the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year, and summarizes information from Licensee Event Reports, the NRC's Operations Center, and Diagnostic Evaluations. NUREG-1272, Vol. 2, No. 2, covers Nonreactors and presents a review of the nonreactors events and misadministration reports that were reported in 1987 and a brief synopsis of AEOD studies published in 1987. Each volume contains a list of the AEOD Reports issued for 1980-1987.

  10. Securities and Exchange Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... [Securities and Exchange Commission Semiannual Regulatory Agenda ] Part XXIII Securities and Exchange Commission Semiannual Regulatory Agenda ] SECURITIES AND EXCHANGE COMMISSION (SEC) SECURITIES AND EXCHANGE COMMISSION 17 CFR Ch. II Regulatory Flexibility Agenda AGENCY: Securities and Exchange Commission. ACTION: Semiannual regulatory...

  11. 77 FR 28407 - Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... January 1998 (63 FR 2426; January 15, 1998), because the underlying basis standard, ANSI N15.8-1974... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants AGENCY:...

  12. 78 FR 38739 - Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... Information DG-5028, was published in the Federal Register on May 14, 2012 (77 FR 28407), for a 60-day public... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants AGENCY:...

  13. Regulatory issues for Waste Isolation Pilot Plant long-term compliance with U.S. Environmental Protection Agency 40 CFR 191B and 268

    SciTech Connect

    Anderson, D.R.; Marietta, M.G.; Higgins, P.J. Jr.

    1993-10-01

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with long-term regulations of the United States Environmental Protection Agency (EPA), specifically the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), and the Land Disposal Restrictions (40 CFR 268) of the Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper provides background information on the regulations, describes the SNL WIPP PA Departments approach to developing a defensible technical basis for consistent compliance evaluations, and summarizes the major observations and conclusions drawn from the 1991 and 1992 PAs.

  14. 76 FR 69120 - Regulatory Changes To Implement the United States/Australian Agreement for Peaceful Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... of America Concerning Peaceful Uses of Nuclear Energy'' (the Agreement). The Agreement prohibits the... United States of America Concerning Peaceful Uses of Nuclear Energy, dated 2010, Australian-obligated... by the Commission on June 30, 1997, and published in the Federal Register on September 3, 1997 (62...

  15. REVIEW OF INDUSTRIES AND GOVERNMENT AGENCIES FOR TECHNOLOGIES APPLICABLE TO DEACTIVATION AND DECOMMISSIONING OF NUCLEAR WEAPONS FACILITIES

    SciTech Connect

    Reilkoff, T. E.; Hetland, M. D.; O'Leary, E. M.

    2002-02-25

    The Deactivation and Decommissioning Focus Area's (DDFA's) mission is to develop, demonstrate, and deploy improved deactivation and decommissioning (D&D) technologies. This mission requires that emphasis be continually placed on identifying technologies currently employed or under development in other nuclear as well as nonnuclear industries and government agencies. In support of DDFA efforts to clean up the U.S. Department of Energy's (DOE's) radiologically contaminated surplus facilities using technologies that improve worker safety, reduce costs, and accelerate cleanup schedules, a study was conducted to identify innovative technologies developed for use in nonnuclear arenas that are appropriate for D&D applications.

  16. Handling of Nuclear Information; Proceedings of the Symposium... Organized by the International Atomic Energy Agency, and Held in Vienna, 16-20 February 1970.

    ERIC Educational Resources Information Center

    International Atomic Energy Agency, Vienna (Austria).

    An international nuclear information system (INIS) which applies computer techniques to the management of the world's nuclear literature is about to come into operation. This prompted the International Atomic Energy Agency to hold a symposium to provide a comprehensive review of the facilities and services available in the world for providing…

  17. The U.S. Department of Energy, National Nuclear Security Agency's Use of Geographic Information Systems for Nuclear Emergency Response Support

    SciTech Connect

    A. L. Guber

    2001-06-01

    The U.S, Department of Energy (DOE), National Nuclear Security Agency's (NNSA) Remote Sensing Laboratory (RSL) provides Geographic Information System (GIS) support during nuclear emergency response activities. As directed by the NNSA, the RSL GIS staff maintains databases and equipment for rapid field deployment during an emergency response. When on location, GIS operators provide information products to on-site emergency managers as well as to emergency managers at the DOE Headquarters (HQ) Emergency Operations Center (EOC) in Washington, D.C. Data products are derived from multiple information sources in the field including radiological prediction models, field measurements taken on the ground and from the air, and pertinent information researched on the Internet. The GIS functions as a central data hub where it supplies the information to response elements in the field, as well as to headquarters officials at HQ during emergency response activities.

  18. The Constellation-EdF nuclear joint venture: regulatory issues and subsequent resolutions

    SciTech Connect

    Pfaff, Ryan; Lubow, Howard; Malko, J. Robert

    2010-03-15

    Corporate restructurings of electric utilities in the U.S. have become a significant and controversial issue due to the differing perspectives of electric utility executives and regulatory commissioners relating to corporate restructuring associated with mergers, diversification, and functional separation of generation, transmission, and distribution. The Maryland Public Service Commission assessed a joint venture between Constellation Energy Group and Electricite de France that reflects these tradeoffs. (author)

  19. Nuclear estradiol binding in rat adipocytes. Regional variations and regulatory influences of hormones.

    PubMed

    Pedersen, S B; Børglum, J D; Eriksen, E F; Richelsen, B

    1991-06-01

    The nuclear estrogen receptor was characterised in isolated rat adipocytes. The binding reaction with [3H]estradiol was performed with intact isolated rat adipocytes and the radioactivity associated with the nucleus was subsequently determined after cell lysis. The nuclear uptake of [3H]estrogen in rat adipocytes was temperature dependent and steroid specific. The steady-state binding was achieved after 30 min at 37 degrees C and was constant for several hours. Estradiol was found to bind to a homogeneous class of nuclear receptors in epididymal adipocytes with an apparent Kd of 3.1 +/- 0.76 nM and a Bmax of 7.98 +/- 1.11 fmol/10(6) cells corresponding to about 4800 receptors per nucleus. The estradiol binding exhibited regional variations in isolated adipocytes. In lean rats the highest receptor number was found in epididymal adipocytes, whereas there was a significantly lower number of nuclear binding sites in perirenal and subcutaneous adipocytes (P less than 0.05), unlike in older and more obese rats where the nuclear estradiol binding was greatest in adipocytes from the perirenal fat depot. Incubations with isoproterenol (10 microM) and dibutyryl-cAMP (2.5 mM) both reduced estradiol binding by 56% (P less than 0.005), while insulin (1 nM) enhanced the estradiol binding by 37% (P less than 0.01). In conclusion, a specific and high affinity nuclear estradiol receptor was demonstrated in rat adipocytes and regional differences in nuclear estradiol binding were detected. Furthermore, it was demonstrated that nuclear estradiol binding could be modulated by other agents known to affect adipocyte metabolism. PMID:1646650

  20. 3 CFR - Regulatory Review

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Regulatory Review Presidential Documents Other Presidential Documents Memorandum of January 30, 2009 Regulatory Review Memorandum for the Heads of Executive Departments and Agencies For well over two decades, the Office of Information and Regulatory Affairs (OIRA) at the Office of Management...

  1. The Creation of a French Basic Nuclear Installation - Description of the Regulatory Process - 13293

    SciTech Connect

    Mahe, Carole; Leroy, Christine

    2013-07-01

    CEA is a French government-funded technological research organization. It has to build a medium-level waste interim storage facility because the geological repository will not be available until 2025. This interim storage facility, called DIADEM, has to be available in 2017. These wastes are coming from the research facilities for spent fuel reprocessing and the dismantling of the most radioactive parts of nuclear facilities. The CEA handles the waste management by inventorying the needs and updating them regularly. The conception of the facility is mainly based on this inventory. It provides quantity and characteristics of wastes and it gives the production schedule until 2035. Beyond mass and volume, main characteristics of these radioactive wastes are chemical nature, radioisotopes, radioactivity, radiation dose, the heat emitted, corrosive or explosive gas production, etc. These characteristics provide information to study the repository safety. DIADEM mainly consists of a concrete cell, isolated from the outside, wherein stainless steel welded containers are stored, stacked in a vertical position in the racks. DIADEM is scheduled to store three types of 8 mm-thick, stainless steel cylindrical containers with an outside diameter 498 mm and height from 620 to 2120 mm. DIADEM will be a basic nuclear installation (INB in French) because of overall activity of radioactive substances stored. The creation of a French basic nuclear installation is subject to authorization according to the French law No. 2006-686 of 13 June 2006 on Transparency and Security in the Nuclear Field. The authorization takes into account the technical and financial capacities of the licensee which must allow him to conduct his project in compliance with these interests, especially to cover the costs of decommissioning the installation and conduct remediation work, and to monitor and maintain its location site or, for radioactive waste disposal installations, to cover the definitive shut

  2. 77 FR 3009 - Knowledge and Abilities Catalog for Nuclear Power Plant Operators: Advanced Boiling Water Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment a draft NUREG, NUREG-2104, Revision 0... (800) 397-4209, (301) 415-4737, or by email to pdr.resource@nrc.gov . The draft NUREG is...

  3. Regulatory Issues and Challenges in Developing Seismic Source Characterizations for New Nuclear Power Plant Applications in the US

    NASA Astrophysics Data System (ADS)

    Fuller, C. W.; Unruh, J.; Lindvall, S.; Lettis, W.

    2009-05-01

    An integral component of the safety analysis for proposed nuclear power plants within the US is a probabilistic seismic hazard assessment (PSHA). Most applications currently under NRC review followed guidance provided within NRC Regulatory Guide 1.208 (RG 1.208) for developing seismic source characterizations (SSC) for their PSHA. Three key components of RG 1.208 guidance is that applicants should: (1) use existing PSHA models and SSCs accepted by the NRC as SSC as a starting point for their SSCs; (2) evaluate new information and data developed since acceptance of the starting model to determine if the model should be updated; and (3) follow guidelines set forth by the Senior Seismic Hazard Analysis Committee (SSHAC) (NUREG/CR-6372) in developing significant updates (i.e., updates should capture SSC uncertainty through representing the "center, body, and range of technical interpretations" of the informed technical community). Major motivations for following this guidance are to ensure accurate representations of hazard and regulatory stability in hazard estimates for nuclear power plants. All current applications with the NRC have used the EPRI-SOG source characterizations developed in the 1980s as their starting point model, and all applicants have followed RG 1.208 guidance in updating the EPRI- SOG model. However, there has been considerable variability in how applicants have interpreted the guidance, and thus there has been considerable variability in the methodology used in updating the SSCs. Much of the variability can be attributed to how different applicants have interpreted the implications of new data, new interpretations of new and/or old data, and new "opinions" of members of the informed technical community. For example, many applicants and the NRC have wrestled with the challenge of whether or not to update SSCs in light of new opinions or interpretations of older data put forth by one member of the technical community. This challenge has been

  4. Report to the Nuclear Regulatory Commission from the staff panel on the Commission's determination of an Extraordinary Nuclear Occurrence (ENO)

    SciTech Connect

    1980-01-01

    The Panel finds that the first criterion, pertaining to whether the accident caused a discharge of radioactive material or levels of radiation offsite as defined in 10 CFR 140.84, has not been met. It further finds that there is presently insufficient information to support any definitive finding as to whether or not the second criterion, relating to damage to persons or property offsite as defined in 10 CFR 140.85, has been met. Since the Panel has not found that both criteria have been met, it recommends that the Commission determine that the accident at Three Mile Island did not constitute an extraordinary nuclear occurrence.

  5. U.S. Nuclear Regulatory Commission Role and Activities Related to U.S. Department of Energy Incidental Waste Determinations

    SciTech Connect

    Bradford, A.H.; Esh, D.W.; Ridge, A.C.

    2006-07-01

    Section 3116 of the Ronald W. Reagan National Defense Authorization Act for Fiscal Year 2005 (NDAA) requires the U.S. Department of Energy (DOE) to consult with the U.S. Nuclear Regulatory Commission (NRC) for certain non-high level waste (HLW) determinations. Under the NDAA, NRC performs consultative technical reviews of DOE's waste determinations and monitors DOE's disposal actions for such waste, but the NRC does not have regulatory authority over DOE's waste disposal activities. The NDAA provides the criteria that must be met to determine that waste is not HLW. The criteria require that the waste does not need to be disposed of in a geologic repository, that highly radioactive radionuclides be removed to the maximum extent practical, and that the performance objectives of 10 CFR 61, Subpart C, be met. The performance objectives contain criteria for protection of the public, protection of inadvertent intruders, protection of workers, and stability of the disposal site after closure. This paper describes NRC's approach to implementing its responsibilities under the NDAA, as well as similar activities being performed for sites not covered by the NDAA. (authors)

  6. Uranium recovery research sponsored by the Nuclear Regulatory Commission at Pacific Northwest Laboratory. Annual progress report, May 1982-May 1983

    SciTech Connect

    Foley, M.G.; Opitz, B.E.; Deutsch, W.J.; Peterson, S.R.; Gee, G.W.; Serne, R.J.; Hartley, J.N.; Thomas, V.W.; Kalkwarf, D.R.; Walters, W.H.

    1983-06-01

    Pacific Northwest Laboratory (PNL) is currently conducting research for the US Nuclear Regulatory Commission (NRC) on uranium recovery process wastes for both active and inactive operations. NRC-sponsored uranium recovery research at PNL is focused on NRC regulatory responsibilities for uranium-recovery operations: license active milling and in situ extraction operations; concur on the acceptability of DOE remedial-action plans for inactive sites; and license DOE to maintain inactive sites following remedial actions. PNL's program consists of four coordinated projects comprised of a program management task and nine research tasks that address the critical technical and safety issues for uranium recovery. Specifically, the projects endeavor to find and evaluate methods to: prevent erosion of tailings piles and prevent radon release from tailings piles; evaluate the effectiveness of interim stabilization techniques to prevent wind erosion and transport of dry tailings from active piles; estimate the dewatering and consolidation behavior of slurried tailings to promote early cover placement; design a cover-protection system to prevent erosion of the cover by expected environmental stresses; reduce seepage into ground water and prevent ground-water degradation; control solution movement and reaction with ground water in in-situ extraction operations; evaluate natural and induced restoration of ground water in in-situ extraction operations; and monitor releases to the environment from uranium recovery facilities.

  7. 76 FR 55137 - Monitoring the Effectiveness of Maintenance at Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... COMMISSION Monitoring the Effectiveness of Maintenance at Nuclear Power Plants AGENCY: Nuclear Regulatory..., ``Monitoring the Effectiveness of Maintenance at Nuclear Power Plants.'' This guide endorses Revision 4A to... Effectiveness of Maintenance at Nuclear Power Plants,'' which provides methods that are acceptable to the...

  8. 77 FR 34093 - License Renewal for Calvert Cliffs Nuclear Power Plant, LLC's

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... COMMISSION License Renewal for Calvert Cliffs Nuclear Power Plant, LLC's AGENCY: Nuclear Regulatory... Cliffs Nuclear Power Plant site near Lusby, Maryland. The NRC has prepared an Environmental Assessment... dated September 17, 2010, Calvert Cliffs Nuclear Power Plant, LLC (CCNPP) submitted an application...

  9. Risk Informed Assessment of Regulatory and Design Requirements for Future Nuclear Power Plants - Final Technical Report

    SciTech Connect

    Ritterbusch, Stanley; Golay, Michael; Duran, Felicia; Galyean, William; Gupta, Abhinav; Dimitrijevic, Vesna; Malsch, Marty

    2003-01-29

    OAK B188 Summary of methods proposed for risk informing the design and regulation of future nuclear power plants. All elements of the historical design and regulation process are preserved, but the methods proposed for new plants use probabilistic risk assessment methods as the primary decision making tool.

  10. 49 CFR 173.471 - Requirements for U.S. Nuclear Regulatory Commission approved packages.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... approved by the NRC in accordance with 10 CFR part 71 must also comply with the following requirements: (a... program required by 10 CFR part 71) with the U.S. Competent Authority as a user of the certificate. (Note... 49 Transportation 2 2011-10-01 2011-10-01 false Requirements for U.S. Nuclear...

  11. 76 FR 78805 - Regulatory Changes To Implement the United States/Australian Agreement for Peaceful Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... America Concerning Peaceful Uses of Nuclear Energy.'' The present NRC action is necessary to relocate a...) published in the Federal Register a final rule (76 FR 69120) that amended the NRC's regulations to implement... action corrects the final rule published on November 8, 2011 (76 FR 69120). Specifically, the new...

  12. 49 CFR 173.471 - Requirements for U.S. Nuclear Regulatory Commission approved packages.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... approved by the NRC in accordance with 10 CFR part 71 must also comply with the following requirements: (a... program required by 10 CFR part 71) with the U.S. Competent Authority as a user of the certificate. (Note... 49 Transportation 2 2013-10-01 2013-10-01 false Requirements for U.S. Nuclear...

  13. 49 CFR 173.471 - Requirements for U.S. Nuclear Regulatory Commission approved packages.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... approved by the NRC in accordance with 10 CFR part 71 must also comply with the following requirements: (a... program required by 10 CFR part 71) with the U.S. Competent Authority as a user of the certificate. (Note... 49 Transportation 2 2014-10-01 2014-10-01 false Requirements for U.S. Nuclear...

  14. Regulatory decision with EPA/NRC/DOE/State Session (Panel)

    SciTech Connect

    O`Donnell, E.

    1995-12-31

    This panel will cover the Nuclear Regulatory Commission`s (NRC) proposed radiation limits in the Branch Technical Position on Low-Level Radioactive Waste Performance Assessment and the Environmental Protection Agency`s (EPA) draft regulation in Part 193. Representatives from NRC and EPA will discuss the inconsistencies in these two regulations. DOE and state representatives will discuss their perspective on how these regulations will affect low-level radioactive waste performance assessments.

  15. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the “120-day clock.” 2 2 Per 10 CFR 50.54(s)(2)(ii), the Commission will determine whether the reactor... April 9, 1985 (published April 18, 1985, 50 FR 15485), and published as Appendix A to 44 CFR part 353... correct exercise deficiencies; (6) correlation of FEMA actions on withdrawal of approvals under 44...

  16. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the “120-day clock.” 2 2 Per 10 CFR 50.54(s)(2)(ii), the Commission will determine whether the reactor... April 9, 1985 (published April 18, 1985, 50 FR 15485), and published as Appendix A to 44 CFR part 353... correct exercise deficiencies; (6) correlation of FEMA actions on withdrawal of approvals under 44...

  17. 75 FR 54917 - Criteria for Nominating Materials Licensees for the U.S. Nuclear Regulatory Commission's Agency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Enforcement Policy (including equivalent violations dispositioned by Alternative Dispute Resolution), or a... Enforcement Policy (including equivalent violations dispositioned by Alternative Dispute Resolution). And... violations dispositioned by Alternative Dispute Resolution). And, there are unique or unusual aspects of...

  18. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... April 9, 1985 (published April 18, 1985, 50 FR 15485), and published as Appendix A to 44 CFR part 353... correct exercise deficiencies; (6) correlation of FEMA actions on withdrawal of approvals under 44 CFR... 10 CFR part 50, appendix E, and certain other fuel cycle and materials licensees which have...

  19. Report of the defense science board task force on defense nuclear agency. Final report

    SciTech Connect

    Not Available

    1993-04-01

    The Task Force recommends that: (1) DNA continue to be the DoD focal point for nuclear expertise; (2) The DNA charter be modified to provide focus for non-nuclear activities of critical importance to the DoD. It gives DNA authority to conduct technology base development for advanced conventional munitions, and become a focal point for technologies related to non- and counter-proliteration of weapon systems of mass destruction and their infrastructure (WMD); and (3) Anticipating cessation of UGETs, DNA should aggressively pursue technology development for AGT, AGT/UGT correlation and advanced computations, with emphasis on new theater scenarios, but with the ability to reconstitute for UGT resumption or AGT for large strategic threats within a year or two.

  20. Covariations in the nuclear chloroplast transcriptome reveal a regulatory master-switch

    PubMed Central

    Richly, Erik; Dietzmann, Angela; Biehl, Alexander; Kurth, Joachim; Laloi, Christophe; Apel, Klaus; Salamini, Francesco; Leister, Dario

    2003-01-01

    The evolution of the endosymbiotic progenitor into the chloroplast organelle was associated with the transfer of numerous chloroplast genes into the nucleus. Hence, inter-organellar signalling, and the co-ordinated expression of sets of nuclear genes, was set up to control the metabolic and developmental status of the chloroplast. Here, we show by the differential-expression analysis of 3,292 genes, that most of the 35 environmental and genetic conditions tested, including plastid signalling mutations, elicit only three main classes of response from the nuclear chloroplast transcriptome. Two classes, probably involving GUN (genomes uncoupled)-type plastid signalling, are characterized by alterations, in opposite directions, in the expression of largely overlapping sets of genes. PMID:12776738

  1. OVERVIEW OF THE U.S. DEPARTMENT OF ENERGY AND NUCLEAR REGULATORY COMMISSION PERFORMANCE ASSESSMENT APPROACHES: CEMENTITIOUS BARRIERS PARTNERSHIP

    SciTech Connect

    Langton, C.; Burns, H.

    2009-05-29

    Engineered barriers including cementitious barriers are used at sites disposing or contaminated with low-level radioactive waste to enhance performance of the natural environment with respect to controlling the potential spread of contaminants. Drivers for using cementitious barriers include: high radionuclide inventory, radionuclide characteristics (e.g., long half-live, high mobility due to chemical form/speciation, waste matrix properties, shallow water table, and humid climate that provides water for leaching the waste). This document comprises the first in a series of reports being prepared for the Cementitious Barriers Partnership. The document is divided into two parts which provide a summary of: (1) existing experience in the assessment of performance of cementitious materials used for radioactive waste management and disposal and (2) sensitivity and uncertainty analysis approaches that have been applied for assessments. Each chapter is organized into five parts: Introduction, Regulatory Considerations, Specific Examples, Summary of Modeling Approaches and Conclusions and Needs. The objective of the report is to provide perspective on the state of the practice for conducting assessments for facilities involving cementitious barriers and to identify opportunities for improvements to the existing approaches. Examples are provided in two contexts: (1) performance assessments conducted for waste disposal facilities and (2) performance assessment-like analyses (e.g., risk assessments) conducted under other regulatory regimes. The introductory sections of each section provide a perspective on the purpose of performance assessments and different roles of cementitious materials for radioactive waste management. Significant experience with assessments of cementitious materials associated with radioactive waste disposal concepts exists in the US Department of Energy Complex and the commercial nuclear sector. Recently, the desire to close legacy facilities has created

  2. The Australian radiation protection and nuclear safety agency megavoltage photon thermoluminescence dosimetry postal audit service 2007-2010.

    PubMed

    Oliver, C P; Butler, D J; Webb, D V

    2012-03-01

    The Australian radiation protection and nuclear safety agency (ARPANSA) has continuously provided a level 1 mailed thermoluminescence dosimetry audit service for megavoltage photons since 2007. The purpose of the audit is to provide an independent verification of the reference dose output of a radiotherapy linear accelerator in a clinical environment. Photon beam quality measurements can also be made as part of the audit in addition to the output measurements. The results of all audits performed between 2007 and 2010 are presented. The average of all reference beam output measurements calculated as a clinically stated dose divided by an ARPANSA measured dose is 0.9993. The results of all beam quality measurements calculated as a clinically stated quality divided by an ARPANSA measured quality is 1.0087. Since 2011 the provision of all auditing services has been transferred from the Ionizing Radiation Standards section to the Australian Clinical Dosimetry Service (ACDS) which is currently housed within ARPANSA. PMID:22302465

  3. Regulatory analysis for the resolution of Generic Safety Issue 29: Bolting degradation or failure in nuclear power plants

    SciTech Connect

    Chang, T.Y.

    1991-09-01

    Generic Safety Issue (GSI)-29 deals with staff concerns about public risk due to degradation or failure of safety-related bolting in nuclear power plants. The issue was initiated in November 1982. Value-impact studies of a mandatory program on safety-related bolting for operating plants were inconclusive: therefore, additional regulatory requirements for operating plants could not be justified in accordance with provisions of 10 CFR 50.109. In addition, based on operating experience with bolting in both nuclear and conventional power plants, the actions already taken through bulletins, generic letters, and information notices, and the industry-proposed actions, the staff concluded that a sufficient technical basis exists for the resolution of GSI-29. The staff further concluded that leakage of bolted pressure joints is possible but catastrophic failure of a reactor coolant pressure boundary joint that will lead to significant accident sequences is highly unlikely. For future plants, it was concluded that a new Standard Review Plant section should be developed to codify existing bolting requirements and industry-developed initiatives. 9 refs., 1 tab.

  4. Reovirus μ2 Protein Inhibits Interferon Signaling through a Novel Mechanism Involving Nuclear Accumulation of Interferon Regulatory Factor 9▿

    PubMed Central

    Zurney, Jennifer; Kobayashi, Takeshi; Holm, Geoffrey H.; Dermody, Terence S.; Sherry, Barbara

    2009-01-01

    The secreted cytokine alpha/beta interferon (IFN-α/β) binds its receptor to activate the Jak-STAT signal transduction pathway, leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an antiviral state. Many viruses have evolved countermeasures to inhibit the IFN pathway, thereby subverting the innate antiviral response. Here, we demonstrate that the mildly myocarditic reovirus type 1 Lang (T1L), but not the nonmyocarditic reovirus type 3 Dearing, represses IFN induction of a subset of ISGs and that this repressor function segregates with the T1L M1 gene. Concordantly, the T1L M1 gene product, μ2, dramatically inhibits IFN-β-induced reporter gene expression. Surprisingly, T1L infection does not degrade components of the ISGF3 complex or interfere with STAT1 or STAT2 nuclear translocation as has been observed for other viruses. Instead, infection with T1L or reassortant or recombinant viruses containing the T1L M1 gene results in accumulation of interferon regulatory factor 9 (IRF9) in the nucleus. This effect has not been previously described for any virus and suggests that μ2 modulates IRF9 interactions with STATs for both ISGF3 function and nuclear export. The M1 gene is a determinant of virus strain-specific differences in the IFN response, which are linked to virus strain-specific differences in induction of murine myocarditis. We find that virus-induced myocarditis is associated with repression of IFN function, providing new insights into the pathophysiology of this disease. Together, these data provide the first report of an increase in IRF9 nuclear accumulation associated with viral subversion of the IFN response and couple virus strain-specific differences in IFN antagonism to the pathogenesis of viral myocarditis. PMID:19109390

  5. An experience of electron beam (EB) irradiated gemstones in Malaysian nuclear agency

    SciTech Connect

    Idris, Sarada Hairaldin, Siti Zulaiha Tajau, Rida Karim, Jamilah Jusoh, Suhaimi Ghazali, Zulkafli; Ahmad, Shamshad

    2014-02-12

    In Nuclear Malaysia, a study on gemstone irradiation using beta particle is conducted. The purpose of the study is to evaluate the gemstone colour enhancement by using different kind of precious and non-precious gemstones. By using irradiation technique, selected gemstones are exposed to highly ionizing radiation electron beam to knock off electrons to generate colour centres culminating in the introduction of deeper colours. The colour centres may be stable or unstable depending on the nature of colour centre produced. The colour change of irradiated stones were measured by HunterLab colour measurement. At 50 kGy, Topaz shows changes colour from colourless to golden. Meanwhile pearl shows changes from pale colour to grey. Kunzite and amethyst shows colour changes from colorless to green and pale colour to purple. Gamma survey meter measurement confirmed that irradiation treatment with 3 MeV electron beam machine does not render any activation that activate the gems to become radioactive.

  6. An experience of electron beam (EB) irradiated gemstones in Malaysian nuclear agency

    NASA Astrophysics Data System (ADS)

    Idris, Sarada; Hairaldin, Siti Zulaiha; Tajau, Rida; Karim, Jamilah; Jusoh, Suhaimi; Ghazali, Zulkafli; Ahmad, Shamshad

    2014-02-01

    In Nuclear Malaysia, a study on gemstone irradiation using beta particle is conducted. The purpose of the study is to evaluate the gemstone colour enhancement by using different kind of precious and non-precious gemstones. By using irradiation technique, selected gemstones are exposed to highly ionizing radiation electron beam to knock off electrons to generate colour centres culminating in the introduction of deeper colours. The colour centres may be stable or unstable depending on the nature of colour centre produced. The colour change of irradiated stones were measured by HunterLab colour measurement. At 50 kGy, Topaz shows changes colour from colourless to golden. Meanwhile pearl shows changes from pale colour to grey. Kunzite and amethyst shows colour changes from colorless to green and pale colour to purple. Gamma survey meter measurement confirmed that irradiation treatment with 3 MeV electron beam machine does not render any activation that activate the gems to become radioactive.

  7. Development of the Updated Environmental Protection Agency Manual of Protective Action Guides (PAGS) and Protective Actions for Nuclear Incidents

    SciTech Connect

    Carter, L.M.

    2008-07-01

    As a student intern with the United States Environmental Protection Agency (EPA) Headquarters, the author was trained in the National Response Plan (NRP) and assisted in the editing of the new (unpublished) EPA Protective Action Guides (PAGs) [1] which has been revised in light of the perceived post 9/11 potential for 'Dirty Bomb' and 'Improvised Nuclear Device' attacks on civilian areas. Technical aspects and the public policy aspects of developing the new guides are discussed. Early Phase initial responses discussed include: Notification of state and/or local authorities, immediate evacuation/sheltering prior to release information or measurements, monitoring of releases and exposure rate measurements, estimation of dose consequences, implementation of protective actions in other areas. The new PAG clarifies the use of 1992 PAGs [2] for incidents other than nuclear power plant accidents, lowers projected thyroid dose for potassium iodine (KI), provides drinking water guidance, includes guidance for long-term site restoration, and updates dosimetry from ICRP 26 to ICRP 60. (authors)

  8. Sample registration software for process automation in the Neutron Activation Analysis (NAA) Facility in Malaysia nuclear agency

    NASA Astrophysics Data System (ADS)

    Rahman, Nur Aira Abd; Yussup, Nolida; Salim, Nazaratul Ashifa Bt. Abdullah; Ibrahim, Maslina Bt. Mohd; Mokhtar, Mukhlis B.; Soh@Shaari, Syirrazie Bin Che; Azman, Azraf B.; Ismail, Nadiah Binti

    2015-04-01

    Neutron Activation Analysis (NAA) had been established in Nuclear Malaysia since 1980s. Most of the procedures established were done manually including sample registration. The samples were recorded manually in a logbook and given ID number. Then all samples, standards, SRM and blank were recorded on the irradiation vial and several forms prior to irradiation. These manual procedures carried out by the NAA laboratory personnel were time consuming and not efficient. Sample registration software is developed as part of IAEA/CRP project on `Development of Process Automation in the Neutron Activation Analysis (NAA) Facility in Malaysia Nuclear Agency (RC17399)'. The objective of the project is to create a pc-based data entry software during sample preparation stage. This is an effective method to replace redundant manual data entries that needs to be completed by laboratory personnel. The software developed will automatically generate sample code for each sample in one batch, create printable registration forms for administration purpose, and store selected parameters that will be passed to sample analysis program. The software is developed by using National Instruments Labview 8.6.

  9. Sample registration software for process automation in the Neutron Activation Analysis (NAA) Facility in Malaysia nuclear agency

    SciTech Connect

    Rahman, Nur Aira Abd Yussup, Nolida; Ibrahim, Maslina Bt. Mohd; Mokhtar, Mukhlis B.; Soh Shaari, Syirrazie Bin Che; Azman, Azraf B.; Salim, Nazaratul Ashifa Bt. Abdullah; Ismail, Nadiah Binti

    2015-04-29

    Neutron Activation Analysis (NAA) had been established in Nuclear Malaysia since 1980s. Most of the procedures established were done manually including sample registration. The samples were recorded manually in a logbook and given ID number. Then all samples, standards, SRM and blank were recorded on the irradiation vial and several forms prior to irradiation. These manual procedures carried out by the NAA laboratory personnel were time consuming and not efficient. Sample registration software is developed as part of IAEA/CRP project on ‘Development of Process Automation in the Neutron Activation Analysis (NAA) Facility in Malaysia Nuclear Agency (RC17399)’. The objective of the project is to create a pc-based data entry software during sample preparation stage. This is an effective method to replace redundant manual data entries that needs to be completed by laboratory personnel. The software developed will automatically generate sample code for each sample in one batch, create printable registration forms for administration purpose, and store selected parameters that will be passed to sample analysis program. The software is developed by using National Instruments Labview 8.6.

  10. NRC - regulator of nuclear safety

    SciTech Connect

    1997-05-01

    The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants. The agency succeeded the Atomic Energy Commission, which previously had responsibility for both developing and regulating nuclear activities. Federal research and development work for all energy sources, as well as nuclear weapons production, is now conducted by the U.S. Department of Energy. Under its responsibility to protect public health and safety, the NRC has three principal regulatory functions: (1) establish standards and regulations, (2) issue licenses for nuclear facilities and users of nuclear materials, and (3) inspect facilities and users of nuclear materials to ensure compliance with the requirements. These regulatory functions relate to both nuclear power plants and to other uses of nuclear materials - like nuclear medicine programs at hospitals, academic activities at educational institutions, research work, and such industrial applications as gauges and testing equipment. The NRC places a high priority on keeping the public informed of its work. The agency recognizes the interest of citizens in what it does through such activities as maintaining public document rooms across the country and holding public hearings, public meetings in local areas, and discussions with individuals and organizations.

  11. Toxicogenomics and the Regulatory Framework

    EPA Science Inventory

    Toxicogenomics presents regulatory agencies with the opportunity to revolutionize their analyses by enabling the collection of information on a broader range of responses than currently considered in traditional regulatory decision making. Analyses of genomic responses are expec...

  12. The use of probabilistic risk assessment to satisfy the Nuclear Regulatory Commission`s maintenance rule

    SciTech Connect

    Dubord, R.M.

    1993-05-01

    Maintenance and inspection at nuclear power plants consumes a large portion of a utility`s resources, making resource allocation for such procedures vital. The NRC Maintenance Rule, due to be implemented in July of 1996, requires utilities to select systems, structures, and components (SSCS) important to safety and to develop a monitoring program to ensure that these SSCs are capable of fulfilling their intended functions. In light of these concerns, two ratios were developed to compare the risk significance of individual components with the amount of plant staff time, or burden, associated with inspecting the component. These risk/burden ratios point out existing disparities between current inspection practices and safety concerns. These ratios can be used to develop new inspection schedules constituting a more equitable risk to burden distribution.

  13. Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB

    PubMed Central

    Coelho, Miguel B; Attig, Jan; Bellora, Nicolás; König, Julian; Hallegger, Martina; Kayikci, Melis; Eyras, Eduardo; Ule, Jernej; Smith, Christopher WJ

    2015-01-01

    Matrin3 is an RNA- and DNA-binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA metabolism has yet been clearly demonstrated. We identified Matrin3 by its interaction with the second RRM domain of the splicing regulator PTB. Using a combination of RNAi knockdown, transcriptome profiling and iCLIP, we find that Matrin3 is a regulator of hundreds of alternative splicing events, principally acting as a splicing repressor with only a small proportion of targeted events being co-regulated by PTB. In contrast to other splicing regulators, Matrin3 binds to an extended region within repressed exons and flanking introns with no sharply defined peaks. The identification of this clear molecular function of Matrin3 should help to clarify the molecular pathology of ALS and other diseases caused by mutations of Matrin3. PMID:25599992

  14. Reactor pressure vessel structural integrity research in the US Nuclear Regulatory Commission HSST and HSSI Programs

    SciTech Connect

    Pennell, W.E.; Corwin, W.R.

    1994-02-01

    This report discusses development on the technology used to assess the safety of irradiation-embrittled nuclear reactor pressure vessels containing flaws. Fracture mechanics tests on reactor pressure vessel steel have shown that local brittle zones do not significantly degrade the material fracture toughness, constraint relaxation at the crack tip of shallow surface flaws results in increased fracture toughness, and biaxial loading reduces but does not eliminate the shallow-flaw fracture toughness elevation. Experimental irradiation investigations have shown that the irradiation-induced shift in Charpy V-notch versus temperature behavior may not be adequate to conservatively assess fracture toughness shifts due to embrittlement and the wide global variations of initial chemistry and fracture properties of a nominally uniform material within a pressure vessel may confound accurate integrity assessments that require baseline properties.

  15. Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module.

    PubMed

    Bagamasbad, Pia D; Bonett, Ronald M; Sachs, Laurent; Buisine, Nicolas; Raj, Samhitha; Knoedler, Joseph R; Kyono, Yasuhiro; Ruan, Yijun; Ruan, Xiaoan; Denver, Robert J

    2015-06-01

    Cooperative, synergistic gene regulation by nuclear hormone receptors can increase sensitivity and amplify cellular responses to hormones. We investigated thyroid hormone (TH) and glucocorticoid (GC) synergy on the Krüppel-like factor 9 (Klf9) gene, which codes for a zinc finger transcription factor involved in development and homeostasis of diverse tissues. We identified regions of the Xenopus and mouse Klf9 genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC. Within these regions, we found an orthologous sequence of approximately 180 bp that is highly conserved among tetrapods, but absent in other chordates, and possesses chromatin marks characteristic of an enhancer element. The Xenopus and mouse approximately 180-bp DNA element conferred synergistic transactivation by hormones in transient transfection assays, so we designate this the Klf9 synergy module (KSM). We identified binding sites within the mouse KSM for TH receptor, GC receptor, and nuclear factor κB. TH strongly increased recruitment of liganded GC receptor and serine 5 phosphorylated (initiating) RNA polymerase II to chromatin at the KSM, suggesting a mechanism for transcriptional synergy. The KSM is transcribed to generate long noncoding RNAs, which are also synergistically induced by combined hormone treatment, and the KSM interacts with the Klf9 promoter and a far upstream region through chromosomal looping. Our findings support that the KSM plays a central role in hormone regulation of vertebrate Klf9 genes, it evolved in the tetrapod lineage, and has been maintained by strong stabilizing selection. PMID:25866873

  16. Deciphering the Regulatory Logic of an Ancient, Ultraconserved Nuclear Receptor Enhancer Module

    PubMed Central

    Bagamasbad, Pia D.; Bonett, Ronald M.; Sachs, Laurent; Buisine, Nicolas; Raj, Samhitha; Knoedler, Joseph R.; Kyono, Yasuhiro; Ruan, Yijun; Ruan, Xiaoan

    2015-01-01

    Cooperative, synergistic gene regulation by nuclear hormone receptors can increase sensitivity and amplify cellular responses to hormones. We investigated thyroid hormone (TH) and glucocorticoid (GC) synergy on the Krüppel-like factor 9 (Klf9) gene, which codes for a zinc finger transcription factor involved in development and homeostasis of diverse tissues. We identified regions of the Xenopus and mouse Klf9 genes 5–6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC. Within these regions, we found an orthologous sequence of approximately 180 bp that is highly conserved among tetrapods, but absent in other chordates, and possesses chromatin marks characteristic of an enhancer element. The Xenopus and mouse approximately 180-bp DNA element conferred synergistic transactivation by hormones in transient transfection assays, so we designate this the Klf9 synergy module (KSM). We identified binding sites within the mouse KSM for TH receptor, GC receptor, and nuclear factor κB. TH strongly increased recruitment of liganded GC receptor and serine 5 phosphorylated (initiating) RNA polymerase II to chromatin at the KSM, suggesting a mechanism for transcriptional synergy. The KSM is transcribed to generate long noncoding RNAs, which are also synergistically induced by combined hormone treatment, and the KSM interacts with the Klf9 promoter and a far upstream region through chromosomal looping. Our findings support that the KSM plays a central role in hormone regulation of vertebrate Klf9 genes, it evolved in the tetrapod lineage, and has been maintained by strong stabilizing selection. PMID:25866873

  17. The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat

    PubMed Central

    Vranková, Stanislava; Barta, Andrej; Klimentová, Jana; Dovinová, Ima; Líšková, Silvia; Dobešová, Zdenka; Pecháňová, Oľga; Kuneš, Jaroslav; Zicha, Josef

    2016-01-01

    Activation of nuclear factor-κB (NF-κB) by increased production of reactive oxygen species (ROS) might induce transcription and expression of different antioxidant enzymes and also of nitric oxide synthase (NOS) isoforms. Thus, we aimed at studying the effect of NF-κB inhibition, caused by JSH-23 (4-methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine) injection, on ROS and NO generation in hereditary hypertriglyceridemic (HTG) rats. 12-week-old, male Wistar and HTG rats were treated with JSH-23 (bolus, 10 μmol, i.v.). After one week, blood pressure (BP), superoxide dismutase (SOD) activity, SOD1, endothelial NOS (eNOS), and NF-κB (p65) protein expressions were higher in the heart of HTG rats compared to control rats. On the other hand, NOS activity was decreased. In HTG rats, JSH-23 treatment increased BP and heart conjugated dienes (CD) concentration (measured as the marker of tissue oxidative damage). Concomitantly, SOD activity together with SOD1 expression was decreased, while NOS activity and eNOS protein expression were increased significantly. In conclusion, NF-κB inhibition in HTG rats led to decreased ROS degradation by SOD followed by increased oxidative damage in the heart and BP elevation. In these conditions, increased NO generation may represent rather a counterregulatory mechanism activated by ROS. Nevertheless, this mechanism was not sufficient enough to compensate BP increase in HTG rats. PMID:27148433

  18. Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation

    PubMed Central

    Mencarelli, Andrea; Distrutti, Eleonora; Renga, Barbara; D'Amore, Claudio; Cipriani, Sabrina; Palladino, Giuseppe; Donini, Annibale; Ricci, Patrizia; Fiorucci, Stefano

    2011-01-01

    Background Adipocytes from mesenteric white adipose tissue amplify the inflammatory response and participate in inflammation-driven immune dysfunction in Crohn's disease by releasing proinflammatory mediators. Peroxisome proliferator-activated receptors (PPAR)-α and -γ, pregnane x receptor (PXR), farnesoid x receptor (FXR) and liver x-receptor (LXR) are ligand-activated nuclear receptor that provide counter-regulatory signals to dysregulated immunity and modulates adipose tissue. Aims To investigate the expression and function of nuclear receptors in intestinal and adipose tissues in a rodent model of colitis and mesenteric fat from Crohn's patients and to investigate their modulation by probiotics. Methods Colitis was induced by TNBS administration. Mice were administered vehicle or VSL#3, daily for 10 days. Abdominal fat explants obtained at surgery from five Crohn's disease patients and five patients with colon cancer were cultured with VSL#3 medium. Results Probiotic administration attenuated development of signs and symptoms of colitis, reduced colonic expression of TNFα, IL-6 and IFNγ and reserved colonic downregulation of PPARγ, PXR and FXR caused by TNBS. Mesenteric fat depots isolated from TNBS-treated animals had increased expression of inflammatory mediators along with PPARγ, FXR, leptin and adiponectin. These changes were prevented by VSL#3. Creeping fat and mesenteric adipose tissue from Crohn's patients showed a differential expression of PPARγ and FXR with both tissue expressing high levels of leptin. Exposure of these tissues to VSL#3 medium abrogates leptin release. Conclusions Mesenteric adipose tissue from rodent colitis and Crohn's disease is metabolically active and shows inflammation-driven regulation of PPARγ, FXR and leptin. Probiotics correct the inflammation-driven metabolic dysfunction. PMID:21829567

  19. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells.

    PubMed

    Sun, GuoQiang; Ye, Peng; Murai, Kiyohito; Lang, Ming-Fei; Li, Shengxiu; Zhang, Heying; Li, Wendong; Fu, Chelsea; Yin, Jason; Wang, Allen; Ma, Xiaoxiao; Shi, Yanhong

    2011-01-01

    miR-137 is a brain-enriched microRNA. Its role in neural development remains unknown. Here we show that miR-137 has an essential role in controlling embryonic neural stem cell fate determination. miR-137 negatively regulates cell proliferation and accelerates neural differentiation of embryonic neural stem cells. In addition, we show that the histone lysine-specific demethylase 1 (LSD1), a transcriptional co-repressor of nuclear receptor TLX, is a downstream target of miR-137. In utero electroporation of miR-137 in embryonic mouse brains led to premature differentiation and outward migration of the transfected cells. Introducing a LSD1 expression vector lacking the miR-137 recognition site rescued miR-137-induced precocious differentiation. Furthermore, we demonstrate that TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-137 by recruiting LSD1 to the genomic regions of miR-137. Thus, miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development. PMID:22068596

  20. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

    PubMed Central

    Sun, GuoQiang; Ye, Peng; Murai, Kiyohito; Lang, Ming-Fei; Li, Shengxiu; Zhang, Heying; Li, Wendong; Fu, Chelsea; Yin, Jason; Wang, Allen; Ma, Xiaoxiao; Shi, Yanhong

    2012-01-01

    miR-137 is a brain-enriched microRNA. Its role in neural development remains unknown. Here we show that miR-137 plays an essential role in controlling embryonic neural stem cell fate determination. miR-137 negatively regulates cell proliferation and accelerates neural differentiation of embryonic neural stem cells. In addition, we show that histone demethylase LSD1, a transcriptional co-repressor of nuclear receptor TLX, is a downstream target of miR-137. In utero electroporation of miR-137 in embryonic mouse brains led to premature differentiation and outward migration of the transfected cells. Introducing a LSD1 expression vector lacking the miR-137 recognition site rescued miR-137-induced precocious differentiation. Furthermore, we demonstrate that TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-137 by recruiting LSD1 to the genomic regions of miR-137. Thus, miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development. PMID:22068596

  1. Inducer effect on the complex formation between rat liver nuclear proteins and cytochrome P450 2B gene regulatory elements.

    PubMed

    Duzhak, T G; Schwartz, E I; Gulyaeva, L F; Lyakhovich, V V

    2002-09-01

    DNA gel retardation assay has been applied to the investigation of complexes between rat liver nuclear proteins and Barbie box positive regulatory element of cytochrome P450 2B (CYP2B) genes. The intensities of B1 and B2 bands detected in the absence of an inducer increased after 30 min protein incubation with phenobarbital (PB) or triphenyldioxane (TPD), but not with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOPOB). In addition, a new complex (B3 band) was for the first time detected under induction by PB, TPD, and TCPOPOB. Increase in the incubation time up to 2 h facilitated the formation of other new complexes (B4 and B5 bands), which were detected only in the presence of TPD. The use of [3H]TPD in hybridization experiments revealed that this inducer, capable of binding to Barbie box DNA, is also present in B4 and B5 complexes. It is probable that the investigated compounds activate the same proteins at the initial induction steps, which correlates with the formation of B1, B2, and B3 complexes. The further induction step might be inducer-specific, as indicated by the formation of B4 and B5 complexes in the presence of TPD only. Thus, the present data suggest the possibility of specific gene activation signaling pathways that are dependent on a particular inducer. PMID:12387719

  2. Description of Multimedia Environment Pollutant Assessment System (MEPAS) version 3.2 modification for the Nuclear Regulatory Commission

    SciTech Connect

    Buck, J.W.; Strenge, D.L.; Hoopes, B.L.

    1997-11-01

    The Multimedia Environmental Pollutant Assessment System (MEPAS) is a software tool developed by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy (DOE) to allow DOE to conduct human health risk analyses nation-wide. This report describes modifications to the MEPAS to meet the requirements of the U.S. Nuclear Regulatory Commission (NRC) staff in their analyses of Site Decommissioning Management Plan sites. In general, these modifications provide the MEPAS, Version 3.2, with the capability of calculating and reporting annual dose/risk information. Modifications were made to the exposure pathway and health impact modules and the water and atmospheric transport modules. Several example cases used to test the MEPAS, Version 3.2, are also presented. The MEPAS, Version 3.2, also contains a new source-term release component that includes models for estimating contaminant loss from three different types of source zones (contaminated aquifer, contaminated pond/surface impoundment, and contaminated vadose zone) due to decay/degradation, leaching, wind suspension, water erosion, overland flow, and/or volatilization. When multiple loss routes are assumed to occur simultaneously, the models account for their interaction and calculate an appropriate pollutant mass budget to each loss route over time.

  3. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.

    PubMed

    Guan, Deyu; Altan-Bonnet, Nihal; Parrott, Andrew M; Arrigo, Cindy J; Li, Quan; Khaleduzzaman, Mohammed; Li, Hong; Lee, Chee-Gun; Pe'ery, Tsafi; Mathews, Michael B

    2008-07-01

    Nuclear factor 90 (NF90) and its C-terminally extended isoform, NF110, have been isolated as DNA- and RNA-binding proteins together with the less-studied protein NF45. These complexes have been implicated in gene regulation, but little is known about their cellular roles and whether they are redundant or functionally distinct. We show that heterodimeric core complexes, NF90-NF45 and NF110-NF45, exist within larger complexes that are more labile and contain multiple NF90/110 isoforms and additional proteins. Depletion of the NF45 subunit by RNA interference is accompanied by a dramatic decrease in the levels of NF90 and NF110. Reciprocally, depletion of NF90 but not of NF110 greatly reduces the level of NF45. Coregulation of NF90 and NF45 is a posttranscriptional phenomenon, resulting from protein destabilization in the absence of partners. Depletion of NF90-NF45 complexes retards cell growth by inhibition of DNA synthesis. Giant multinucleated cells containing nuclei attached by constrictions accumulate when either NF45 or NF90, but not NF110, is depleted. This study identified NF45 as an unstable regulatory subunit of NF90-NF45 complexes and uncovered their critical role in normal cell division. Furthermore, the study revealed that NF90 is functionally distinct from NF110 and is more important for cell growth. PMID:18458058

  4. U.S. Nuclear Regulatory Commission Extremely Low Probability of Rupture pilot study : xLPR framework model user's guide.

    SciTech Connect

    Kalinich, Donald A.; Sallaberry, Cedric M.; Mattie, Patrick D.

    2010-12-01

    For the U.S. Nuclear Regulatory Commission (NRC) Extremely Low Probability of Rupture (xLPR) pilot study, Sandia National Laboratories (SNL) was tasked to develop and evaluate a probabilistic framework using a commercial software package for Version 1.0 of the xLPR Code. Version 1.0 of the xLPR code is focused assessing the probability of rupture due to primary water stress corrosion cracking in dissimilar metal welds in pressurizer surge nozzles. Future versions of this framework will expand the capabilities to other cracking mechanisms, and other piping systems for both pressurized water reactors and boiling water reactors. The goal of the pilot study project is to plan the xLPR framework transition from Version 1.0 to Version 2.0; hence the initial Version 1.0 framework and code development will be used to define the requirements for Version 2.0. The software documented in this report has been developed and tested solely for this purpose. This framework and demonstration problem will be used to evaluate the commercial software's capabilities and applicability for use in creating the final version of the xLPR framework. This report details the design, system requirements, and the steps necessary to use the commercial-code based xLPR framework developed by SNL.

  5. 78 FR 39284 - Technical Guidance for Assessing Environmental Justice in Regulatory Analysis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... AGENCY Technical Guidance for Assessing Environmental Justice in Regulatory Analysis AGENCY... Regulatory Analysis.'' The purpose of this notice is to extend the public comment period by 60 days. The... Environmental Justice in Regulatory Analysis, Environmental Protection Agency, Mailcode: 1890T,...

  6. Safety research programs sponsored by Office of Nuclear Regulatory Research. Quarterly progress report, January 1-March 31, 1983. Volume 3, No. 1

    SciTech Connect

    Bari, R A; Cerbone, R J; Ginsberg, T; Greene, G A; Guppy, J G; Hall, R E; Luckas, Jr, W J; Reich, M; Saha, P; Sastre, C

    1983-06-01

    The projects reported are the following: HTGR Safety Evaluation, SSC Development, Validation and Application, CRBR Balance of Plant Modeling, Thermal-Hydraulic Reactor Safety Experiments, LWR Plant Analyzer Development, LWR Code Assessment and Application; Stress Corrosion Cracking of PWR Steam Generator Tubing, Bolting Failure Analysis, Probability Based Load Combinations for Design of Category I Structures, Mechanical Piping Benchmark Problems, Soil Structure Interaction; Human Error Data for Nuclear Power Plant Safety Related Events, Criteria for Human Engineering Regulatory Guides and Human Factors in Nuclear Power Plant Safeguards.

  7. Safety research programs sponsored by Office of Nuclear Regulatory Research. Volume 3. No. 2. Quarterly progress report, April 1-June 30, 1983

    SciTech Connect

    Bari, R A; Cerbone, R J; Ginsberg, T; Greene, G A; Guppy, J G; Hall, R E; Luckas, Jr, W J; Reich, M; Saha, P; Sastre, C

    1983-09-01

    The projects reported are the following: HTGR Safety Evaluation, SSC development, Validation and Application, CRBR balance of plant modeling, thermal-hydraulic reactor safety experiments, LWR plant analyzer development, LWR code assessment and application, thermal reactor code development (RAMONA-3B); stress corrosion cracking of PWR steam generator tubing, bolting failure analysis, probability based load combinations for design of category I structures, mechanical piping benchmark problems; human error data for nuclear power plant safety related events, criteria for human engineering regulatory guides and human factors in nuclear power plant safeguards.

  8. Performance-Based (Risk-Informed) Regulation: A Regulatory Perspective

    SciTech Connect

    Kadambi, N. Prasad

    2005-01-15

    Performance-based regulation (PBR) has been mandated at the national level in the United States and at the agency level, where appropriate, at the U.S. Nuclear Regulatory Commission (USNRC). Guidance has been developed that implements the USNRC's definitions of PBR and other such conceptual regulatory improvements. This paper describes why PBR is important, what constitutes PBR in the context of direction provided at the USNRC, and how PBR can be implemented using a five-step process. The process steps articulate questions to be posed by the analyst regarding various aspects of a regulatory issue so that a suitably performance-based resolution can be developed. A regulatory alternative thus developed can be included among other options to be considered as part of the regulatory decision-making process.

  9. 78 FR 71675 - License Amendment Application for Vermont Yankee Nuclear Power Station

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... published in the Federal Register on August 6, 2013 (78 FR 47789). However, by letter dated September 26... COMMISSION License Amendment Application for Vermont Yankee Nuclear Power Station AGENCY: Nuclear Regulatory... Operating License No. DPR-28 for the Vermont Yankee Nuclear Power Station, located in Windham County,...

  10. 78 FR 1636 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ...This Regulatory Agenda is a semiannual summary of all current and projected rulemakings, existing regulations, and completed actions of the Small Business Administration (SBA). For this fall edition of the SBA's Regulatory Agenda, a Regulatory Plan that contains a list of the Agency's most important and significant regulatory actions and a Statement of Regulatory Priorities is also included.......

  11. Department of Justice Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] Part XI Department of Justice Semiannual Regulatory Agenda ] DEPARTMENT OF JUSTICE (DOJ) DEPARTMENT OF JUSTICE 8 CFR Ch. V 21 CFR Ch. I 27 CFR Ch. II 28 CFR Ch. I, V Regulatory Agenda AGENCY: Department of Justice. ACTION: Semiannual regulatory agenda....

  12. Nuclear Regulatory Commission issuances

    SciTech Connect

    Not Available

    1994-03-01

    This report includes the issuances received during the specified period from Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

  13. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-11-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  14. Nuclear Regulatory Commission Issuances

    SciTech Connect

    1996-05-01

    This report contains the issuances received during the specified period from the Atomic Safety and Licensing Board only. The two issuances included relate to: (1) suspension of byproduct material license for Eastern Testing and Inspection, Inc., and (2) license renewal for the Georgia Tech research reactor.

  15. Nuclear Regulatory Commission Issuances

    SciTech Connect

    Not Available

    1994-10-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  16. Nuclear Regulatory Commission Issuances

    SciTech Connect

    1996-12-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

  17. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-09-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  18. Video image processing for nuclear safeguards

    SciTech Connect

    Rodriguez, C.A.; Howell, J.A.; Menlove, H.O.; Brislawn, C.M.; Bradley, J.N.; Chare, P.; Gorten, J.

    1995-09-01

    The field of nuclear safeguards has received increasing amounts of public attention since the events of the Iraq-UN conflict over Kuwait, the dismantlement of the former Soviet Union, and more recently, the North Korean resistance to nuclear facility inspections by the International Atomic Energy Agency (IAEA). The role of nuclear safeguards in these and other events relating to the world`s nuclear material inventory is to assure safekeeping of these materials and to verify the inventory and use of nuclear materials as reported by states that have signed the nuclear Nonproliferation Treaty throughout the world. Nuclear safeguards are measures prescribed by domestic and international regulatory bodies such as DOE, NRC, IAEA, and EURATOM and implemented by the nuclear facility or the regulatory body. These measures include destructive and non destructive analysis of product materials/process by-products for materials control and accountancy purposes, physical protection for domestic safeguards, and containment and surveillance for international safeguards.

  19. Regulatory affairs administration as regulatory policy determinant

    SciTech Connect

    Forcier, J.R.

    1984-05-10

    It is the thesis of this article that the processing of a utility company's regulation-related work, the supporting tasks and the manner in which they are completed, can and does have a significant impact on the final results or work product of the regulatory affairs function, including even, potentially, the action of the regulatory agency. The article is therefore full of practical pointers on how the interface with the regulatory authority can best be organized, managed, and carried through to the attainment of optimum results for the utility. 2 references.

  20. Restructuring nuclear regulations.

    PubMed Central

    Mossman, Kenneth L

    2003-01-01

    Nuclear regulations are a subset of social regulations (laws to control activities that may negatively impact the environment, health, and safety) that concern control of ionizing radiation from radiation-producing equipment and from radioactive materials. The impressive safety record among nuclear technologies is due, in no small part, to the work of radiation safety professionals and to a protection system that has kept pace with the rapid technologic advancements in electric power generation, engineering, and medicine. The price of success, however, has led to a regulatory organization and philosophy characterized by complexity, confusion, public fear, and increasing economic costs. Over the past 20 years, regulatory costs in the nuclear sector have increased more than 250% in constant 1995 U.S. dollars. Costs of regulatory compliance can be reduced sharply, particularly when health and environmental benefits of risk reduction are questionable. Three key regulatory areas should be closely examined and modified to improve regulatory effectiveness and efficiency: a) radiation protection should be changed from a risk-based to dose-based system; b) the U.S. government should adopt the modern metric system (International System of Units), and radiation quantities and units should be simplified to facilitate international communication and public understanding; and c) a single, independent office is needed to coordinate nuclear regulations established by U.S. federal agencies and departments. PMID:12515683

  1. 10 CFR 14.19 - When a claim is filed with more than one agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... treat the matter as a request for reconsideration of the final denial under 10 CFR 14.39, unless suit... 10 Energy 1 2014-01-01 2014-01-01 false When a claim is filed with more than one agency. 14.19 Section 14.19 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS...

  2. 10 CFR 14.19 - When a claim is filed with more than one agency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... treat the matter as a request for reconsideration of the final denial under 10 CFR 14.39, unless suit... 10 Energy 1 2013-01-01 2013-01-01 false When a claim is filed with more than one agency. 14.19 Section 14.19 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS...

  3. 10 CFR 14.19 - When a claim is filed with more than one agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... treat the matter as a request for reconsideration of the final denial under 10 CFR 14.39, unless suit... 10 Energy 1 2011-01-01 2011-01-01 false When a claim is filed with more than one agency. 14.19 Section 14.19 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS...

  4. 75 FR 38151 - Governors' Designees Receiving Advance Notification of Transportation of Nuclear Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... 6, 1982 (47 FR 596 and 47 FR 600), the U.S. Nuclear Regulatory Commission (NRC) published in the.... Godwin, Director, Arizona Radiation Same. Regulatory Agency, 4814 South 40th Street, Phoenix, AZ 85040..., Radiation Control Section, Arkansas Same. Department of Health, 4815 West Markham Street, Mail Slot...

  5. 14 CFR 1267.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Federal agency or agency. 1267.645 Section 1267.645 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... Executive Office of the President), or any independent regulatory agency....

  6. 14 CFR 1267.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Federal agency or agency. 1267.645 Section 1267.645 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... Executive Office of the President), or any independent regulatory agency....

  7. Time to Reject the Linear-No Threshold Hypothesis and Accept Thresholds and Hormesis: A Petition to the U.S. Nuclear Regulatory Commission.

    PubMed

    Marcus, Carol S

    2015-07-01

    On February 9, 2015, I submitted a petition to the U.S. Nuclear Regulatory Commission (NRC) to reject the linear-no threshold (LNT) hypothesis and ALARA as the bases for radiation safety regulation in the United States, using instead threshold and hormesis evidence. In this article, I will briefly review the history of LNT and its use by regulators, the lack of evidence supporting LNT, and the large body of evidence supporting thresholds and hormesis. Physician acceptance of cancer risk from low dose radiation based upon federal regulatory claims is unfortunate and needs to be reevaluated. This is dangerous to patients and impedes good medical care. A link to my petition is available: http://radiationeffects.org/wp-content/uploads/2015/03/Hormesis-Petition-to-NRC-02-09-15.pdf, and support by individual physicians once the public comment period begins would be extremely important. PMID:26018704

  8. 77 FR 70846 - Regulatory Guide 1.182, “Assessing and Managing Risk Before Maintenance Activities at Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... (Rev.) 0, ``Assessing and Managing Risk Before Maintenance Activities at Nuclear Power Plants... 1.160, ``Monitoring the Effectiveness of Maintenance at Nuclear Power Plants.'' ADDRESSES: Please... withdrawing RG 1.182, Rev. 0, ``Assessing and Managing Risk Before Maintenance Activities at Nuclear...

  9. The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.

    PubMed

    Akagi, Kazutaka; Kageyama, Yuji; Kayashima, Yasunari; Takakura, Yusuke; Hirose, Susumu; Ueda, Hitoshi

    2013-01-01

    Nuclear receptor transcription factor family members share target sequence similarity; however, little is known about how these factors exert their specific regulatory control. Here, we examine the mechanism regulating the expression of the Drosophila EDG84A gene, a target gene of the orphan nuclear receptor βFTZ-F1, as a model to study the cooperative behavior among nuclear receptors. We show that the three nuclear receptors βFTZ-F1, DHR3, and DHR39 bind to a common element in the EDG84A promoter. The expression level of the EDG84A promoter-lacZ reporter genes in DHR39-induced and mutant animals, respectively, suggests that DHR39 works as a repressor. The activity of a reporter gene carrying a mutation preventing DHR3 binding was reduced in ftz-f1 mutants and rescued by the induced expression of βFTZ-F1, suggesting that DHR3 and βFTZ-F1 activate the EDG84A gene in a redundant manner. A reporter gene carrying a mutation that abolishes DHR39 and FTZ-F1 binding was prematurely expressed, and the expression level of the reporter gene carrying a mutation preventing DHR3 binding was reduced. These findings suggest that the temporal expression of this gene is mainly controlled by βFTZ-F1 but that the binding of DHR3 is also important. Comparison of the binding site sequence among Drosophila species suggests that DHR3 binding ability was gained after the melanogaster subgroup evolved, and this ability may contribute to the robust expression of this gene. These results show the complicated regulatory mechanisms utilized by multiple nuclear receptors to properly regulate the expression of their target gene through a single target site. PMID:23137796

  10. Dynamic epigenetic regulation of the Oct4 and Nanog regulatory regions during neural differentiation in rhesus nuclear transfer embryonic stem cells.

    PubMed

    Wang, Kai; Chen, Ying; Chang, Eun-Ah; Knott, Jason G; Cibelli, Jose B

    2009-12-01

    Oct4 and Nanog are crucial for maintaining pluripotency in embryonic stem (ES) cells and early-stage embryos. In the present study, the status of DNA methylation and of histone modifications in the regulatory regions of Oct4 and Nanog in rhesus nuclear transfer-derived ES (ntES) cells was compared with in vitro fertilized embryo-derived ES (IVFES) cell counterparts. Dynamic changes in DNA methylation during differentiation into neural lineage were also monitored and correlated with mRNA abundance and protein levels of both genes. In ntES cells Oct4 exhibited mono-allelic methylation along with relatively lower mRNA levels, and its transcription was seen predominantly from the unmethylated allele. In contrast, in IVFES cells Oct4 was hypomethylated on both alleles and had relatively higher transcript levels, suggesting incomplete reprogramming of DNA methylation on the Oct4 gene following somatic cell nuclear transfer. During neuronal differentiation, Oct4 underwent biallelic methylation and reduced amounts of Oct4 mRNA were detected in both types of ES cells. Analysis of Nanog regulatory regions revealed that both alleles were hypomethylated and similar levels of Nanog transcripts were expressed in ntES cells and IVFES cells. During neuronal differentiation both alleles were methylated and reduced amounts of Nanog mRNA were detected. Other epigenetic modifications including histone 3 lysine 4, 9, and 27 trimethylation (H3K4me3, H3K9me3, and H3K27me3) showed similar patterns around the regulatory regions of Oct4 and Nanog in both kinds of ES cells. During neural differentiation, dramatic enrichment of H3K27me3 and H3K9me3 (repressive marks) was observed on Oct4 and Nanog regulatory regions. Differentiation of ntES and IVFES cells correlated with the silencing of Oct4 and Nanog, reactivation of the neural marker genes Pax6, N-Oct3, and Olig2, and dynamic changes in histone modifications in the upstream regions of Pax6 and N-Oct3. In short, although ES cells derived

  11. Regulatory cross-cutting topics for fuel cycle facilities.

    SciTech Connect

    Denman, Matthew R.; Brown, Jason; Goldmann, Andrew Scott; Louie, David

    2013-10-01

    This report overviews crosscutting regulatory topics for nuclear fuel cycle facilities for use in the Fuel Cycle Research&Development Nuclear Fuel Cycle Evaluation and Screening study. In particular, the regulatory infrastructure and analysis capability is assessed for the following topical areas:Fire Regulations (i.e., how applicable are current Nuclear Regulatory Commission (NRC) and/or International Atomic Energy Agency (IAEA) fire regulations to advance fuel cycle facilities)Consequence Assessment (i.e., how applicable are current radionuclide transportation tools to support risk-informed regulations and Level 2 and/or 3 PRA) While not addressed in detail, the following regulatory topic is also discussed:Integrated Security, Safeguard and Safety Requirement (i.e., how applicable are current Nuclear Regulatory Commission (NRC) regulations to future fuel cycle facilities which will likely be required to balance the sometimes conflicting Material Accountability, Security, and Safety requirements.)

  12. Independent Verification and Validation Of SAPHIRE 8 Software Quality Assurance Plan Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Kent Norris

    2010-03-01

    This report provides an evaluation of the Software Quality Assurance Plan. The Software Quality Assurance Plan is intended to ensure all actions necessary for the software life cycle; verification and validation activities; documentation and deliverables; project management; configuration management, nonconformance reporting and corrective action; and quality assessment and improvement have been planned and a systematic pattern of all actions necessary to provide adequate confidence that a software product conforms to established technical requirements; and to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  13. A self-teaching curriculum for the NRC/SNL (Nuclear Regulatory Commission/Sandia National Laboratory) low-level waste performance assessment methodology

    SciTech Connect

    Chu, M.S.Y.; Kozak, M.W.; Campbell, J.E. ); Thompson, B.H. )

    1991-01-01

    A performance assessment methodology has been developed for use by the US Nuclear Regulatory Commission in evaluating license applications for low-level waste disposal facilities. This report provides detailed guidance on input and output procedures for the computer codes recommended for use in the methodology. Seven sample problems are provided for various aspects of a performance assessment analysis of a simple hypothetical conceptual model. When combined, these sample problems demonstrate how the methodology is used to produce a dose history for the site under normal conditions, and to demonstrate an analysis of an intruder scenario. 20 refs., 26 figs., 4 tabs.

  14. Independent Verification and Validation Of SAPHIRE 8 Software Quality Assurance Plan Project Number: N6423 U.S. Nuclear Regulatory Commission

    SciTech Connect

    Kent Norris

    2010-02-01

    This report provides an evaluation of the Software Quality Assurance Plan. The Software Quality Assurance Plan is intended to ensure all actions necessary for the software life cycle; verification and validation activities; documentation and deliverables; project management; configuration management, nonconformance reporting and corrective action; and quality assessment and improvement have been planned and a systematic pattern of all actions necessary to provide adequate confidence that a software product conforms to established technical requirements; and to meet the contractual commitments prepared by the sponsor; the Nuclear Regulatory Commission.

  15. Securities and Exchange Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] Part XXIV Securities and Exchange Commission Semiannual Regulatory Agenda ] SECURITIES AND EXCHANGE COMMISSION (SEC) SECURITIES AND EXCHANGE COMMISSION 17 CFR Ch. II Regulatory Flexibility Agenda AGENCY: Securities and Exchange Commission. ACTION:...

  16. Chemical and radioactive carcinogens in cigarettes: associated health impacts and responses of the tobacco industry, U.S. Congress, and federal regulatory agencies.

    PubMed

    Moeller, Dade W; Sun, Lin-Shen C

    2010-11-01

    ²¹⁰Po and ²¹⁰Pb were discovered in tobacco in 1964. This was followed by detailed assessments of the nature of their deposition, and accompanying dose rates to the lungs of cigarette smokers. Subsequent studies revealed: (1) the sources and pathways through which they gain access to tobacco; (2) the mechanisms through which they preferentially deposit in key segments of the bronchial epithelium; and (3) the fact that the accompanying alpha radiation plays a synergistic role in combination with the chemical carcinogens, to increase the fatal cancer risk coefficient in cigarette smokers by a factor of 8 to 25. Nonetheless, it was not until 2009 that Congress mandated that the Food and Drug Administration require that the cigarette industry reveal the presence of these carcinogens. In the meantime, cigarette smoking has become not only the number one source of cancer deaths in the United States, but also a major contributor to heart disease and other health impacts. If the latter effects are included, smoking is estimated to have caused an average of 443,000 deaths and 5.1 million years of potential life lost among the U.S. population each year from 2000 through 2004. The estimated associated collective dose is more than 36 times that to the workers at all the U.S. nuclear power plants, U.S. Department of Energy nuclear weapons facilities, and crews of all the vessels in the U.S. Nuclear Navy. This unnecessary source of lung cancer deaths demands the utmost attention of the radiation protection and public health professions. PMID:20938238

  17. Southern state radiological emergency preparedness and response agencies

    SciTech Connect

    Not Available

    1988-11-01

    This Report provides information on the state agencies assigned to radioactive materials transportation incidents in 16 Southern States Energy Board member states. For each, the report lists the agencies with primary authority for preparedness and response, their responsibilities and personnel within the agencies who can offer additional information on their radioactive materials transportation programs. The report also lists each state's emergency team members and its laboratory and analytical capabilities. Finally, the governor's designee for receiving advance notification of high-level radioactive materials and spent fuel shipments under 10 CFR Parts 71 and 73 of the US Nuclear Regulatory Commission's regulations is listed for each state. Part 71 requires prenotification for large quantity radioactive waste shipments. Part 73 addresses prenotification for spent nuclear reactor fuel shipments.

  18. Southern state radiological emergency preparedness and response agencies

    SciTech Connect

    Not Available

    1988-11-01

    This Report provides information on the state agencies assigned to radioactive materials transportation incidents in 16 Southern States Energy Board member states. For each, the report lists the agencies with primary authority for preparedness and response, their responsibilities and personnel within the agencies who can offer additional information on their radioactive materials transportation programs. The report also lists each state`s emergency team members and its laboratory and analytical capabilities. Finally, the governor`s designee for receiving advance notification of high-level radioactive materials and spent fuel shipments under 10 CFR Parts 71 and 73 of the US Nuclear Regulatory Commission`s regulations is listed for each state. Part 71 requires prenotification for large quantity radioactive waste shipments. Part 73 addresses prenotification for spent nuclear reactor fuel shipments.

  19. Evaluation of the applicability of existing nuclear power plant regulatory requirements in the U.S. to advanced small modular reactors.

    SciTech Connect

    LaChance, Jeffrey L.; Wheeler, Timothy A.; Farnum, Cathy Ottinger; Middleton, Bobby D.; Jordan, Sabina Erteza; Duran, Felicia Angelica; Baum, Gregory A.

    2013-05-01

    The current wave of small modular reactor (SMR) designs all have the goal of reducing the cost of management and operations. By optimizing the system, the goal is to make these power plants safer, cheaper to operate and maintain, and more secure. In particular, the reduction in plant staffing can result in significant cost savings. The introduction of advanced reactor designs and increased use of advanced automation technologies in existing nuclear power plants will likely change the roles, responsibilities, composition, and size of the crews required to control plant operations. Similarly, certain security staffing requirements for traditional operational nuclear power plants may not be appropriate or necessary for SMRs due to the simpler, safer and more automated design characteristics of SMRs. As a first step in a process to identify where regulatory requirements may be met with reduced staffing and therefore lower cost, this report identifies the regulatory requirements and associated guidance utilized in the licensing of existing reactors. The potential applicability of these regulations to advanced SMR designs is identified taking into account the unique features of these types of reactors.

  20. 78 FR 27235 - Technical Guidance for Assessing Environmental Justice in Regulatory Analysis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... AGENCY Technical Guidance for Assessing Environmental Justice in Regulatory Analysis AGENCY..., ``Technical Guidance for Assessing Environmental Justice in Regulatory Analysis.'' The purpose of this... regulatory analyses. This guidance takes into account EPA's past experience in integrating EJ into...

  1. International Atomic Energy Agency specialists meeting on experience in ageing, maintenance, and modernization of instrumentation and control systems for improving nuclear power plant availability

    SciTech Connect

    Not Available

    1993-10-01

    This report presents the proceedings of the Specialist`s Meeting on Experience in Aging, Maintenance and Modernization of Instrumentation and Control Systems for Improving Nuclear Power Plant Availability that was held at the Ramada Inn in Rockville, Maryland on May 5--7, 1993. The Meeting was presented in cooperation with the Electric Power Research Institute, Oak Ridge National Laboratory and the International Atomic Energy Agency. There were approximately 65 participants from 13 countries at the Meeting. Individual reports have been cataloged separately.

  2. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

    PubMed Central

    Lau, Joe F.; Parisien, Jean-Patrick; Horvath, Curt M.

    2000-01-01

    The transduction of type I interferon signals to the nucleus relies on activation of a protein complex, ISGF3, involving two signal transducers and activators of transcription (STAT) proteins, STAT1 and STAT2, and the interferon (IFN) regulatory factor (IRF) protein, p48/ISGF3γ. The STAT subunits are cytoplasmically localized in unstimulated cells and rapidly translocate to the nucleus of IFN-stimulated cells, but the p48/ISGF3γ protein is found in both the nucleus and the cytoplasm, regardless of IFN stimulation. Here, we demonstrate that p48 is efficiently and constitutively targeted to the nucleus. Analysis of the subcellular distribution of green fluorescent protein-p48 fragments indicates that p48 contains a bipartite nuclear retention signal within its amino-terminal DNA-binding domain. This signal is preserved in two other IRF proteins involved in immune responses, ICSBP and IRF4. Mutations to clustered basic residues within amino acids 50–100 of p48 or IRF4 disrupt their nuclear accumulation, and DNA-binding ability is not required for nuclear targeting. This is the only example of a nuclear localization signal for any ISGF3 component and assigns a second function to the IRF DNA-binding domain. We also demonstrate that the nuclear distribution of p48 is dramatically altered by coexpression of the STAT2 protein, indicating that STAT2 forms a cytoplasmic complex with p48, overriding the intrinsic p48 nuclear targeting. Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid activation of the IFN response. These findings suggest that analogous mechanisms may exist for regulating the distribution of other IRF proteins. PMID:10860992

  3. A Regulatory Analysis and Reassessment of U.S. Environmental Protection Agency Listed Hazardous Waste Numbers for Applicability to the INTEC Liquid Waste System

    SciTech Connect

    Gilbert, K.L.; Venneman, T.E.

    1998-12-01

    This report concludes that there are four listed hazardous waste numbers (F001, F002, F005, and U134) applicable to the waste in the Process Equipment Waste Evaporator (PEWE) liquid waste system at the Idaho National Engineering and Environmental Laboratory. The chemical constituents associated with these listed hazardous waste numbers, including those listed only for ignitability are identified. The RCRA Part A permit application hazardous waste numbers identify chemical constituents that may be treated or stored by the PEWE liquid waste system either as a result of a particular characteristic (40 CFR, Subpart C) or as a result of a specific process (40 CFR 261, Subpart D). The RCRA Part A permit application for the PEWE liquid waste system identifies the universe of Environmental Protection Agency (EPA) hazardous waste numbers [23 characteristic (hazardous waste codes) numbers and 105 listed numbers (four F-listed hazardous waste numbers, 20 P-listed hazardous waste numbers, and 81 U-listed hazardous waste numbers)] deemed acceptable for storage and treatment. This evaluation, however, identifies only listed wastes (and their chemical constituents) that have actually entered the PEWE liquid waste system and would, therefore, be assigned to the PEWE liquids and treatment residuals.

  4. 78 FR 67206 - Qualification Tests for Safety-Related Actuators in Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Plants'' on May 1, 2013, (78 FR 25488) for a 60 day public comment period. The public comment period... COMMISSION Qualification Tests for Safety-Related Actuators in Nuclear Power Plants AGENCY: Nuclear... Commission (NRC) is issuing revision 1 to regulatory guide (RG) 1.73, ``Qualification Tests for...

  5. 77 FR 40385 - Withdrawal of Regulatory Guide 7.3; Procedures for Picking Up and Receiving Packages of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Packaging Requirements for Shipment and Receipt of Radioactive Material,'' which was issued in March 28... Radioactive Material AGENCY: Nuclear Regulatory Commission. ACTION: Notice of withdrawal; correction. SUMMARY... Commission) is withdrawing RG 7.3, ``Procedures for Picking Up and Receiving Packages of Radioactive...

  6. 78 FR 31614 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... 2007 (ML070630003). On October 22, 2012 (77 FR 64564), the staff issued the proposed DC/COL-ISG-024... COMMISSION Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles AGENCY....221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants,'' in support of...

  7. Cost tradeoffs in consequence management at nuclear power plants: A risk based approach to setting optimal long-term interdiction limits for regulatory analyses

    SciTech Connect

    Mubayi, V.

    1995-05-01

    The consequences of severe accidents at nuclear power plants can be limited by various protective actions, including emergency responses and long-term measures, to reduce exposures of affected populations. Each of these protective actions involve costs to society. The costs of the long-term protective actions depend on the criterion adopted for the allowable level of long-term exposure. This criterion, called the ``long term interdiction limit,`` is expressed in terms of the projected dose to an individual over a certain time period from the long-term exposure pathways. The two measures of offsite consequences, latent cancers and costs, are inversely related and the choice of an interdiction limit is, in effect, a trade-off between these two measures. By monetizing the health effects (through ascribing a monetary value to life lost), the costs of the two consequence measures vary with the interdiction limit, the health effect costs increasing as the limit is relaxed and the protective action costs decreasing. The minimum of the total cost curve can be used to calculate an optimal long term interdiction limit. The calculation of such an optimal limit is presented for each of five US nuclear power plants which were analyzed for severe accident risk in the NUREG-1150 program by the Nuclear Regulatory Commission.

  8. A new method of passive counting of nuclear missile warheads -a white paper for the Defense Threat Reduction Agency

    SciTech Connect

    Morris, Christopher; Durham, J. Matthew; Guardincerri, Elena; Bacon, Jeffrey Darnell; Wang, Zhehui; Fellows, Shelby; Poulson, Daniel Cris; Plaud-Ramos, Kenie Omar; Daughton, Tess Marie; Johnson, Olivia Ruth

    2015-07-31

    Cosmic ray muon imaging has been studied for the past several years as a possible technique for nuclear warhead inspection and verification as part of the New Strategic Arms Reduction Treaty between the United States and the Russian Federation. The Los Alamos team has studied two different muon imaging methods for this application, using detectors on two sides and one side of the object of interest. In this report we present results obtained on single sided imaging of configurations aimed at demonstrating the potential of this technique for counting nuclear warheads in place with detectors above the closed hatch of a ballistic missile submarine.

  9. International cooperation in nuclear R and D

    SciTech Connect

    Lawrence, C.

    1982-03-01

    The Atoms for Peace program of international cooperation gave the US the responsibility of sharing scientific knowledge and nuclear materials while training foreign scientists. Europe responded with the European Atomic Energy Community (EURATOM) and the International Atomic Energy Agency (IAEA) for cooperative research and multilateral exchanges on reactor safety and waste management. The US Nuclear Regulatory Commission has about 40 international research arrangements and cooperative program agreements, some of which are multilateral and others bilateral. The Electric Power Research Institute eight-member Nuclear Safety Analysis Center reflects the growing concern for nuclear safety. (DCK)

  10. REGULATORY STRATEGIES TO MINIMIZE GENERATION OF REGULATED WASTES FROM CLEANUP, CONTINUED USE OR DECOMMISSIONING OF NUCLEAR FACILITIES CONTAMINATED WITH POLYCHLORINATED BIPHENYLS (PCBS) - 11198

    SciTech Connect

    Lowry, N.

    2010-11-05

    Disposal costs for liquid PCB radioactive waste are among the highest of any category of regulated waste. The high cost is driven by the fact that disposal options are extremely limited. Toxic Substances Control Act (TSCA) regulations require most liquids with PCBs at concentration of {ge} 50 parts-per-million to be disposed by incineration or equivalent destructive treatment. Disposal fees can be as high as $200 per gallon. This figure does not include packaging and the cost to transport the waste to the disposal facility, or the waste generator's labor costs for managing the waste prior to shipment. Minimizing the generation of liquid radioactive PCB waste is therefore a significant waste management challenge. PCB spill cleanups often generate large volumes of waste. That is because the removal of PCBs typically requires the liberal use of industrial solvents followed by a thorough rinsing process. In a nuclear facility, the cleanup process may be complicated by the presence of radiation and other occupational hazards. Building design and construction features, e.g., the presence of open grating or trenches, may also complicate cleanup. In addition to the technical challenges associated with spill cleanup, selection of the appropriate regulatory requirements and approach may be challenging. The TSCA regulations include three different sections relating to the cleanup of PCB contamination or spills. EPA has also promulgated a separate guidance policy for fresh PCB spills that is published as Subpart G of 40 CFR 761 although it is not an actual regulation. Applicability is based on the circumstances of each contamination event or situation. Other laws or regulations may also apply. Identification of the allowable regulatory options is important. Effective communication with stakeholders, particularly regulators, is just as important. Depending on the regulatory path that is taken, cleanup may necessitate the generation of large quantities of regulated waste

  11. 78 FR 1574 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... and stability to receive opioid addiction treatment medication. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153 NPRM Comment Period End 08/18/09 Final Action 12/06/12 77 FR 72752 Regulatory... FR Cite NPRM 03/00/13 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Charles...

  12. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 2. Evaluation of seismic designs: a review of seismic design requirements for Nuclear Power Plant Piping

    SciTech Connect

    Not Available

    1985-04-01

    This document reports the position and recommendations of the NRC Piping Review Committee, Task Group on Seismic Design. The Task Group considered overlapping conservation in the various steps of seismic design, the effects of using two levels of earthquake as a design criterion, and current industry practices. Issues such as damping values, spectra modification, multiple response spectra methods, nozzle and support design, design margins, inelastic piping response, and the use of snubbers are addressed. Effects of current regulatory requirements for piping design are evaluated, and recommendations for immediate licensing action, changes in existing requirements, and research programs are presented. Additional background information and suggestions given by consultants are also presented.

  13. Requiring an Office of Investigations within the Nuclear Regulatory Commission. Introduced in the House of Representatives, One Hundredth Congress, Second Session, September 29, 1988

    SciTech Connect

    Not Available

    1988-01-01

    This bill amends the Energy Reorganization Act of 1974 to add a new section 205A that establishes within the Nuclear Regulatory Commission (NRC) a statutory Office of Investigation (OI) and establishes a director of this office who reports directly to the five NRC Commissioners. The new section also sets out the responsibility of the office for initiating and conducting investigations into violations of laws the NRC implements that relate to violations involving wrongdoing. The OI is charged with reporting violations of federal criminal law to the Department of Justice. The Committee on Energy and Commerce considered the bill, report favorably on it without amendment, and recommend its passage by the whole House of Representatives.

  14. Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway*

    PubMed Central

    Han, Sungwon; Bahmanyar, Shirin; Zhang, Peixiang; Grishin, Nick; Oegema, Karen; Crooke, Roseann; Graham, Mark; Reue, Karen; Dixon, Jack E.; Goodman, Joel M.

    2012-01-01

    Lipin-1 catalyzes the formation of diacylglycerol from phosphatidic acid. Lipin-1 mutations cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated, and the yeast ortholog Pah1p becomes membrane-associated and active upon dephosphorylation by the Nem1p-Spo7p membrane complex. A mammalian ortholog of Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly “dullard”), but its Spo7p-like partner is unknown, and the need for its existence is debated. Here, we identify the metazoan ortholog of Spo7p, TMEM188, renamed nuclear envelope phosphatase 1-regulatory subunit 1 (NEP1-R1). CTDNEP1 and NEP1-R1 together complement a nem1Δspo7Δ strain to block endoplasmic reticulum proliferation and restore triacylglycerol levels and lipid droplet number. The two human orthologs are in a complex in cells, and the amount of CTDNEP1 is increased in the presence of NEP1-R1. In the Caenorhabditis elegans embryo, expression of nematode CTDNEP1 and NEP1-R1, as well as lipin-1, is required for normal nuclear membrane breakdown after zygote formation. The expression pattern of NEP1-R1 and CTDNEP1 in human and mouse tissues closely mirrors that of lipin-1. CTDNEP1 can dephosphorylate lipins-1a, -1b, and -2 in human cells only in the presence of NEP1-R1. The nuclear fraction of lipin-1b is increased when CTDNEP1 and NEP1-R1 are co-expressed. Therefore, NEP1-R1 is functionally conserved from yeast to humans and functions in the lipin activation pathway. PMID:22134922

  15. Mitigating Community Impacts of Energy Development: Some Examples for Coal and Nuclear Generating Plants in the United States.

    ERIC Educational Resources Information Center

    Peelle, Elizabeth

    The Hartsville, Tennessee nuclear reactor site, the coal plant at Wheatland, Wyoming, and the nuclear plant at Skagit, Washington have mitigation plans developed in response to a federal, state, and local regulatory agency, respectively; the three mitigation plans aim at internalizing community-level social costs and benefits during the…

  16. 75 FR 63214 - Errata Notice; Notice of Public Workshop on a Potential Rulemaking for Spent Nuclear Fuel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... Reprocessing Facilities issued on July 23, 2010 (75 FR 45167, August 2, 2010), states that the date and... COMMISSION Errata Notice; Notice of Public Workshop on a Potential Rulemaking for Spent Nuclear Fuel Reprocessing Facilities AGENCY: Nuclear Regulatory Commission. ACTION: Errata Notice; Notice of Public...

  17. 75 FR 5355 - Notice of Extension of Comment Period for NUREG-1934, Nuclear Power Plant Fire Modeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ... Modeling Application Guide (NPP FIRE MAG), Draft Report for Comment'' in the Federal Register (74 FR 68873... COMMISSION Notice of Extension of Comment Period for NUREG-1934, Nuclear Power Plant Fire Modeling Application Guide (NPP FIRE MAG), Draft Report for Comment AGENCY: Nuclear Regulatory Commission....

  18. 78 FR 32278 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... 13, 2012 (77 FR 67685). The supplements had no effect on the no significant hazards consideration... COMMISSION Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to Information in Tier 1, Table 3.3-1 AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and...

  19. Proceedings of the US Nuclear Regulatory Commission twentieth water reactor safety information meeting; Volume 2, Severe accident research, Thermal hydraulics

    SciTech Connect

    Weiss, A.J.

    1993-03-01

    This three-volume report contains papers presented at the Twentieth Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, during the week of October 21--23, 1992. The papers describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included 10 different papers presented by researchersfrom CEC, China, Finland, France, Germany, Japan, Spain and Taiwan. Selected papers have been processed separately for inclusion in the Energy Science and Technology Database.

  20. Hepatitis B virus nuclear export elements: RNA stem-loop α and β, key parts of the HBV post-transcriptional regulatory element.

    PubMed

    Lim, Chun Shen; Brown, Chris M

    2016-09-01

    Many viruses contain RNA elements that modulate splicing and/or promote nuclear export of their RNAs. The RNAs of the major human pathogen, hepatitis B virus (HBV) contain a large (~600 bases) composite cis-acting 'post-transcriptional regulatory element' (PRE). This element promotes expression from these naturally intronless transcripts. Indeed, the related woodchuck hepadnavirus PRE (WPRE) is used to enhance expression in gene therapy and other expression vectors. These PRE are likely to act through a combination of mechanisms, including promotion of RNA nuclear export. Functional components of both the HBV PRE and WPRE are 2 conserved RNA cis-acting stem-loop (SL) structures, SLα and SLβ. They are within the coding regions of polymerase (P) gene, and both P and X genes, respectively. Based on previous studies using mutagenesis and/or nuclear magnetic resonance (NMR), here we propose 2 covariance models for SLα and SLβ. The model for the 30-nucleotide SLα contains a G-bulge and a CNGG(U) apical loop of which the first and the fourth loop residues form a CG pair and the fifth loop residue is bulged out, as observed in the NMR structure. The model for the 23-nucleotide SLβ contains a 7-base-pair stem and a 9-nucleotide loop. Comparison of the models with other RNA structural elements, as well as similarity searches of human transcriptome and viral genomes demonstrate that SLα and SLβ are specific to HBV transcripts. However, they are well conserved among the hepadnaviruses of non-human primates, the woodchuck and ground squirrel. PMID:27031749

  1. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 3. Evaluation of potential for pipe breaks

    SciTech Connect

    Not Available

    1984-11-01

    The Executive Director for Operations (EDO) in establishing the Piping Review Committee concurred in its overall scope that included an evaluation of the potential for pipe breaks. The Pipe Break Task Group has responded to this directive. This report summarizes a review of regulatory documents and contains the Task Group's recommendations for application of the leak-before-break (LBB) approach to the NRC licensing process. The LBB approach means the application of fracture mechanics technology to demonstrate that high energy fluid piping is very unlikely to experience double-ended ruptures or their equivalent as longitudinal or diagonal splits. The Task Group's reommendations and discussion are founded on current and ongoing NRC staff actions as presented in Section 3.0 of this report. Additional more detailed comments and discussion are presented in Section 5.0 and in Appendices A and B. The obvious issues are the reexamination of the large pipe break criteria and the implications of any changes in the criteria as they influence items such as jet loads and pipe whip. The issues have been considered and the Task Group makes the following recommendations.

  2. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 4. Evaluation of other loads and load combinations

    SciTech Connect

    Not Available

    1984-12-01

    Six topical areas were covered by the Task Group on Other Dynamic Loads and Load Combinations as described below: Event Combinations - dealing with the potential simultaneous occurrence of earthquakes, pipe ruptures, and water hammer events in the piping design basis; Response Combinations - dealing with multiply supported piping with independent inputs, the sequence of combinations between spacial and modal components of response, and the treatment of high frequency modes in combination with low frequency modal responses; Stress Limits/Dynamic Allowables - dealing with inelastic allowables for piping and strain rate effects; Water Hammer Loadings - dealing with code and design specifications for these loadings and procedures for identifying potential water hammer that could affect safety; Relief Valve Opening and Closing Loads - dealing with the adequacy of analytical tools for predicting the effects of these events and, in addition, with estimating effective cycles for fatigue evaluations; and Piping Vibration Loads - dealing with evaluation procedures for estimating other than seismic vibratory loads, the need to consider reciprocating and rotary equipment vibratory loads, and high frequency vibratory loads. NRC staff recommendations or regulatory changes and additional study appear in this report.

  3. Technical and regulatory review of the Rover nuclear fuel process for use on Fort St. Vrain fuel

    SciTech Connect

    Hertzler, T. )

    1993-02-01

    This report describes the results of an analysis for processing and final disposal of Fort St. Vrain (FSV) irradiated fuel in Rover-type equipment or technologies. This analysis includes an evaluation of the current Rover equipment status and the applicability of this technology in processing FSV fuel. The analyses are based on the physical characteristics of the FSV fuel and processing capabilities of the Rover equipment. Alternate FSV fuel disposal options are also considered including fuel-rod removal from the block, disposal of the empty block, or disposal of the entire fuel-containing block. The results of these analyses document that the current Rover hardware is not operable for any purpose, and any effort to restart this hardware will require extensive modifications and re-evaluation. However, various aspects of the Rover technology, such as the successful fluid-bed burner design, can be applied with modification to FSV fuel processing. The current regulatory climate and technical knowledge are not adequately defined to allow a complete analysis and conclusion with respect to the disposal of intact fuel blocks with or without the fuel rods removed. The primary unknowns include the various aspects of fuel-rod removal from the block, concentration of radionuclides remaining in the graphite block after rod removal, and acceptability of carbon in the form of graphite in a high level waste repository.

  4. Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells

    PubMed Central

    Okoh, V O; Garba, N A; Penney, R B; Das, J; Deoraj, A; Singh, K P; Sarkar, S; Felty, Q; Yoo, C; Jackson, R M; Roy, D

    2015-01-01

    Background: 17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, the underlying mechanism of this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory factor-1 (NRF-1) and p27 contribute to E2-induced growth of MCF-7 breast cancer cells. Methods: Chromatin immunoprecipitation, qPCR, mass spectrometry, redox western blot, colony formation, cell proliferation, ROS assay, and immunofluorescence microscopy were used to study the role of NRF-1. Results: The major novel finding of this study is the demonstration of oxidative modification of phosphatases PTEN and CDC25A by E2-generated ROS along with the subsequent activation of AKT and ERK pathways that culminated in the activation of NRF-1 leading to the upregulation of cell cycle genes. 17β-Oestradiol-induced ROS by influencing nuclear proteins p27 and Jab1 also contributed to the growth of MCF-7 cells. Conclusions: Taken together, our results present evidence in the support of E2-induced ROS-mediated AKT signalling leading to the activation of NRF-1-regulated cell cycle genes as well as the impairment of p27 activity, which is presumably necessary for the growth of MCF-7 cells. These observations are important because they provide a new paradigm by which oestrogen may contribute to the growth of breast cancer. PMID:25965299

  5. Independent Agency Regulatory Analysis Act of 2013

    THOMAS, 113th Congress

    Sen. Portman, Rob [R-OH

    2013-06-18

    06/18/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Independent Agency Regulatory Analysis Act of 2012

    THOMAS, 112th Congress

    Sen. Portman, Rob [R-OH

    2012-08-01

    08/01/2012 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling*

    PubMed Central

    Wang, Yu-Bo; Tan, Bo; Mu, Rui; Chang, Yan; Wu, Min; Tu, Hai-Qing; Zhang, Yu-Cheng; Guo, Sai-Sai; Qin, Xuan-He; Li, Tao; Li, Wei-Hua; Li, Ai-Ling; Zhang, Xue-Min; Li, Hui-Yan

    2015-01-01

    Excessive nuclear factor κB (NF-κB) activation should be precisely controlled as it contributes to multiple immune and inflammatory diseases. However, the negative regulatory mechanisms of NF-κB activation still need to be elucidated. Various types of polyubiquitin chains have proved to be involved in the process of NF-κB activation. Many negative regulators linked to ubiquitination, such as A20 and CYLD, inhibit IκB kinase activation in the NF-κB signaling pathway. To find new NF-κB signaling regulators linked to ubiquitination, we used a small scale siRNA library against 51 ubiquitin-associated domain-containing proteins and screened out UBXN1, which contained both ubiquitin-associated and ubiquitin regulatory X (UBX) domains as a negative regulator of TNFα-triggered NF-κB activation. Overexpression of UBXN1 inhibited TNFα-triggered NF-κB activation, although knockdown of UBXN1 had the opposite effect. UBX domain-containing proteins usually act as valosin-containing protein (VCP)/p97 cofactors. However, knockdown of VCP/p97 barely affected UBXN1-mediated NF-κB inhibition. At the same time, we found that UBXN1 interacted with cellular inhibitors of apoptosis proteins (cIAPs), E3 ubiquitin ligases of RIP1 in the TNFα receptor complex. UBXN1 competitively bound to cIAP1, blocked cIAP1 recruitment to TNFR1, and sequentially inhibited RIP1 polyubiquitination in response to TNFα. Therefore, our findings demonstrate that UBXN1 is an important negative regulator of the TNFα-triggered NF-κB signaling pathway by mediating cIAP recruitment independent of VCP/p97. PMID:25681446

  8. Intra-articular nuclear factor-κB blockade ameliorates collagen-induced arthritis in mice by eliciting regulatory T cells and macrophages.

    PubMed

    Min, S-Y; Yan, M; Du, Y; Wu, T; Khobahy, E; Kwon, S-R; Taneja, V; Bashmakov, A; Nukala, S; Ye, Y; Orme, J; Sajitharan, D; Kim, H-Y; Mohan, C

    2013-05-01

    Nuclear factor (NF)-κB is a transcription factor implicated in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA). Here we have examined the effect of intra-articular administration of the IKK inhibitor, NEMO-binding domain peptide (NBD), on the severity of collagen-induced arthritis (CIA). NBD peptides were injected intra-articularly into the knee joints of DBA/1J mice after the onset of disease. Collagen-injected mice given a scrambled peptide served as controls. Arthritis severity was determined by visual examination of paws. Intra-articular NBD injection reduced the arthritis score and ameliorated morphological signs of bone destruction compared to the controls. Serum levels of type-II collagen-specific immunoglobulin (Ig)G2a antibodies were lower in NBD-treated mice versus the control mice, whereas the levels of type-II collagen-specific IgG1 antibodies were increased by NBD treatment. NBD treatment diminished the proinflammatory cytokines interleukin (IL)-17 and interferon (IFN)-γ in serum, but increased the regulatory cytokine IL-10. NBD-treated CIA mice exhibited significantly higher percentages and numbers of forkhead box protein 3 (FoxP3(+)) CD4(+) CD25(+) regulatory T cells than controls. Immunofluorescence analysis of NBD-treated mice revealed that FoxP3 and Ym1, a marker of alternatively activated macrophages, were juxtaposed to each other within draining inguinal lymph nodes. Intra-articular administration of NBD peptide is effective as an experimental therapy in a murine model of RA. Nevertheless, the intra-articular treatment modality is still associated with systemic effects on the immune system. PMID:23574318

  9. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 5. Summary - Piping Review Committee conclusions and recommendations

    SciTech Connect

    Not Available

    1985-04-01

    This document summarizes a comprehensive review of NRC requirements for Nuclear Piping by the US NRC Piping Review Committee. Four topical areas, addressed in greater detail in Volumes 1 through 4 of this report, are included: (1) Stress Corrosion Cracking in Piping of Boiling Water Reactor Plants; (2) Evaluation of Seismic Design; (3) Evaluation of Potential for Pipe Breaks; and (4) Evaluation of Other Dynamic Loads and Load Combinations. This volume summarizes the major issues, reviews the interfaces, and presents the Committee's conclusions and recommendations for updating NRC requirements on these issues. This report also suggests research or other work that may be required to respond to issues not amenable to resolution at this time.

  10. Video imaging for Nuclear Safeguards

    SciTech Connect

    Bradley, J.N.; Brislawn, C.M.; Brown, J.E.; Rodriguez, C.A.; Stoltz, L.A.

    1994-04-01

    The field of Nuclear Safeguards has received increasing amounts of public attention since the events of the Iraq-UN conflict over Kuwait, the dismantlement of the former Soviet Union, and more recently, the North Korean resistance to nuclear facility inspections by the International Atomic Energy Agency (IAEA). The role of nuclear safeguards in these and other events relating to the world`s nuclear material inventory is to assure safekeeping of these materials and to verify the inventory and usage of these materials as reported by states that have signed the Nuclear Nonproliferation Treaty. Nuclear Safeguards are measures prescribed by domestic and international regulatory bodies and implemented by the nuclear facility or the regulatory body. These measures include destructive and nondestructive analysis of product materials and process by-products for materials control and accountancy purposes, physical protection for domestic safeguards, and containment and surveillance for international safeguards. In this presentation we will introduce digital video image processing and analysis systems that have been developed at Los Alamos National Laboratory for application to the nuclear safeguards problem. Of specific interest to this audience is the detector-activated predictive wavelet transform image coding used to reduce drastically the data storage requirements for these unattended, remote safeguards systems.

  11. Regulatory guidance document

    SciTech Connect

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  12. 76 FR 13172 - Placer County Water Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... Energy Regulatory Commission Placer County Water Agency Notice of Application Tendered for Filing with... Filed: February 23, 2011 d. Applicant: Placer County Water Agency e. Name of Project: Middle Fork... Manager, Placer County Water Agency, 144 Ferguson Road, Auburn, CA 95603; Telephone: (530) 823-4490....

  13. 76 FR 58541 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ...The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to OMB for review the following proposal for the collection of information under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35). The NRC hereby informs potential respondents that an agency may not conduct or sponsor, and that a person is not required to respond to, a collection of information......

  14. 76 FR 64977 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ...The U.S. Nuclear Regulatory Commission (NRC) has recently submitted to the Office of Management and Budget (OMB) for review the following proposal for the collection of information under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. chapter 35). The NRC hereby informs potential respondents that an agency may not conduct or sponsor, and that a person is not required to......

  15. 76 FR 59066 - Notice of Regulatory Review Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ...; ] FEDERAL HOUSING FINANCE AGENCY 12 CFR Chapter XII Notice of Regulatory Review Plan AGENCY: Federal Housing Finance Agency. ACTION: Notice and request for comments. SUMMARY: The Federal Housing Finance Agency (FHFA... Counsel, Attention: Comments/2011-N-10, Federal Housing Finance Agency, Fourth Floor, 1700 G Street,...

  16. Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase

    PubMed Central

    Bacot-Davis, Valjean R.; Ciomperlik, Jessica J.; Basta, Holly A.; Cornilescu, Claudia C.; Palmenberg, Ann C.

    2014-01-01

    Cardiovirus Leader (L) proteins induce potent antihost inhibition of active cellular nucleocytoplasmic trafficking by triggering aberrant hyperphosphorylation of nuclear pore proteins (Nup). To achieve this, L binds protein RanGTPase (Ran), a key trafficking regulator, and diverts it into tertiary or quaternary complexes with required kinases. The activity of L is regulated by two phosphorylation events not required for Ran binding. Matched NMR studies on the unphosphorylated, singly, and doubly phosphorylated variants of Mengovirus L (LM) show both modifications act together to partially stabilize a short internal α-helix comprising LM residues 43–46. This motif implies that ionic and Van der Waals forces contributed by phosphorylation help organize downstream residues 48–67 into a new interface. The full structure of LM as bound to Ran (unlabeled) and Ran (216 aa) as bound by LM (unlabeled) places LM into the BP1 binding site of Ran, wrapped by the conformational flexible COOH tail. The arrangement explains the tight KD for this complex and places the LM zinc finger and phosphorylation interface as surface exposed and available for subsequent reactions. The core structure of Ran, outside the COOH tail, is not altered by LM binding and remains accessible for canonical RanGTP partner interactions. Pull-down assays identify at least one putative Ran:LM partner as an exportin, Crm1, or CAS. A model of Ran:LM:Crm1, based on the new structures suggests LM phosphorylation status may mediate Ran’s selection of exportin(s) and cargo(s), perverting these native trafficking elements into the lethal antihost Nup phosphorylation pathways. PMID:25331866

  17. 75 FR 70044 - Withdrawal of Regulatory Guide 1.39

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Development Branch, Division of Engineering, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory... of RG 1.28 and RG 1.33 adequately address the related Quality Assurance Program with the latest ANSI... Development Branch, Division of Engineering, Office of Nuclear Regulatory Research. BILLING CODE 7590-01-P...

  18. Current regulatory and licensing status for byproduct sources, facilities and applications

    SciTech Connect

    Tingey, G.L.; Jensen, G.A.; Hazelton, R.F.

    1985-02-01

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig.

  19. Current regulatory and licensing status for byproduct sources, facilities and applications

    NASA Astrophysics Data System (ADS)

    Tingey, G. L.; Jensen, G. A.; Hazelton, R. F.

    1985-02-01

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights.

  20. Response to Nuclear Regulatory Commission`s ten questions pertaining to site-specific models for use in the license termination rule: Multimedia Environmental Pollutant Assessment System (MEPAS)

    SciTech Connect

    Buck, J.W.; Whelan, G.; Strenge, D.L.; Hoopes, B.L.; McDonald, J.P.; Castleton, K.J.; Pelton, M.A.; Gelston, G.M.; Taira, R.Y.

    1998-05-01

    This paper is in response to the US Nuclear Regulatory Commission (NRC) ten questions posed at the Modeling Workshop held November 13 and 14, 1997. The ten questions were developed in advance of the workshop to allow model developers to prepare a presentation at the Workshop. This paper is an expanded version of the Multimedia Environmental Pollutant Assessment System (MEPAS) presentation given at the Modeling Workshop by Pacific Northwest National Laboratory (PNNL) staff. This paper is organized by the ten questions asked by the NRC, each section devoted to a single question. The current version of methodology is MEPAS 3.2 (NRC 1997) and the discussion in this paper will pertain to that version. In some cases, MEPAS 4.0, which is currently being developed under the Framework for Risk Analysis in Multimedia Environmental Systems (FRAMES) (Whelan et al. 1997), will be referenced to inform the reader of potential capabilities in the near future. A separate paper is included in the document that discusses the FRAMES concept.

  1. Comparison of Standard Light Water Reactor Cross-Section Libraries using the United States Nuclear Regulatory Commission Boiling Water Reactor Benchmark Problem

    NASA Astrophysics Data System (ADS)

    Kulesza, Joel A.; Arzu Alpan, F.

    2016-02-01

    This paper describes a comparison of contemporary and historical light water reactor shielding and pressure vessel dosimetry cross-section libraries for a boiling water reactor calculational benchmark problem. The calculational benchmark problem was developed at Brookhaven National Laboratory by the request of the U. S. Nuclear Regulatory Commission. The benchmark problem was originally evaluated by Brookhaven National Laboratory using the Oak Ridge National Laboratory discrete ordinates code DORT and the BUGLE-93 cross-section library. In this paper, the Westinghouse RAPTOR-M3G three-dimensional discrete ordinates code was used. A variety of cross-section libraries were used with RAPTOR-M3G including the BUGLE93, BUGLE-96, and BUGLE-B7 cross-section libraries developed at Oak Ridge National Laboratory and ALPAN-VII.0 developed at Westinghouse. In comparing the calculated fast reaction rates using the four aforementioned cross-section libraries in the pressure vessel capsule, for six dosimetry reaction rates, a maximum relative difference of 8% was observed. As such, it is concluded that the results calculated by RAPTOR-M3G are consistent with the benchmark and further that the different vintage BUGLE cross-section libraries investigated are largely self-consistent.

  2. Keratinocyte sensitization to tumour necrosis factor-induced nuclear factor kappa B activation by the E2 regulatory protein of human papillomaviruses.

    PubMed

    Boulabiar, Manel; Boubaker, Samir; Favre, Michel; Demeret, Caroline

    2011-10-01

    Human papillomavirus (HPV) life cycle requires extensive manipulation of cell signalling to provide conditions adequate for viral replication within the stratified epithelia. In this regard, we show that the E2 regulatory protein of α, β and μ-HPV genotypes enhances tumour necrosis factor (TNF)-induced activation of nuclear factor kappa B (NF-κB). This activation is mediated by the N-terminal domain of E2, but does not rely on its transcriptional properties. It is independent of the NF-κB regulator Tax1BP1, which nevertheless interacts with all the E2 proteins. E2 specifically activates NF-κB pathways induced by TNF, while interleukin-1-induced pathways are not affected. E2 stimulates the activating K63-linked ubiquitination of TRAF5, and interacts with both TRAF5 and TRAF6. Our data suggest that E2 potentiates TNF-induced NF-κB signalling mediated by TRAF5 activation through direct binding. Since NF-κB controls epithelial differentiation, this activity may be involved in the commitment of infected keratinocytes to proliferation arrest and differentiation, both required for the implementation of the productive viral cycle. PMID:21715600

  3. Public opinion factors regarding nuclear power

    SciTech Connect

    Benson, B.

    1991-12-31

    This paper is an effort to identify, as comprehensively as possible, public concerns about nuclear power, and to assess, where possible, the relative importance of these concerns as they relate to government regulation of and policy towards nuclear power. It is based on some two dozen in-depth interviews with key communicators representing the nuclear power industry, the environmental community, and government, as well as on the parallel efforts in our research project: (1) review of federal court case law, (2) a selective examination of the Nuclear Regulatory Commission (NRC) administrative process, and (3) the preceding George Mason University research project in this series. The paper synthesizes our findings about public attitudes towards nuclear power as expressed through federal court case law, NRC administrative law, public opinion surveys, and direct personal interviews. In so doing, we describe the public opinion environment in which the nuclear regulatory process must operate. Our premise is that public opinion ultimately underlies the approaches government agencies take towards regulating nuclear power, and that, to the degree that the nuclear power industry`s practices are aligned with public opinion, a more favorable regulatory climate is possible.

  4. Public opinion factors regarding nuclear power

    SciTech Connect

    Benson, B.

    1991-01-01

    This paper is an effort to identify, as comprehensively as possible, public concerns about nuclear power, and to assess, where possible, the relative importance of these concerns as they relate to government regulation of and policy towards nuclear power. It is based on some two dozen in-depth interviews with key communicators representing the nuclear power industry, the environmental community, and government, as well as on the parallel efforts in our research project: (1) review of federal court case law, (2) a selective examination of the Nuclear Regulatory Commission (NRC) administrative process, and (3) the preceding George Mason University research project in this series. The paper synthesizes our findings about public attitudes towards nuclear power as expressed through federal court case law, NRC administrative law, public opinion surveys, and direct personal interviews. In so doing, we describe the public opinion environment in which the nuclear regulatory process must operate. Our premise is that public opinion ultimately underlies the approaches government agencies take towards regulating nuclear power, and that, to the degree that the nuclear power industry's practices are aligned with public opinion, a more favorable regulatory climate is possible.

  5. U.S. Nuclear Regulatory Commission Review of U.S. Department of Energy Non-High Level Waste Determination for Idaho National Laboratory Tank Farm Facility

    SciTech Connect

    Barr, C.S.; Yin, X.; Camper, L.W.; Whited, A.R.; Dinwiddie, C.L.; Howard, L.D.; Pabalan, R.T.; Pickett, D.

    2007-07-01

    The National Defense Authorization Act for Fiscal Year 2005 (NDAA) authorized the United States Department of Energy (DOE) to determine whether certain radioactive waste related to the reprocessing of spent nuclear fuel is not high-level-waste (HLW). The NDAA applies to DOE facilities in the States of South Carolina and Idaho. DOE must consult with the United States Nuclear Regulatory Commission (NRC) as part of its waste determination. NRC must coordinate with the affected state to monitor DOE's disposal actions to assess compliance with 10 CFR 61, Subpart C, performance objectives. The performance objectives in 10 CFR Part 61, Subpart C, contain requirements for protection of the public, inadvertent intruders, individuals during operations, and stability of the disposal site after closure. In September 2005, DOE submitted to NRC a draft non-HLW determination for waste incidental to reprocessing, including sodium-bearing waste [note: Sodium-bearing waste is a generic term used to describe radioactive wastes comprised of second- and third-cycle extraction fluid and decontamination fluids. This waste contains less activity and generally poses less risk than first-cycle extraction fluid (first-cycle extraction fluid contains most of the fission products)] (SBW) stored in the Idaho Nuclear Technology and Engineering Center tank farm facility (INTEC TFF) at the Idaho National Laboratory (INL). DOE plans to grout the underground tanks and concrete vaults that house these tanks to stabilize the waste in situ. DOE prepared a waste determination to demonstrate compliance with NDAA criteria, including a supporting performance assessment to demonstrate compliance with the performance objectives. To carry out its consultative role required by the NDAA, NRC uses a risk-informed, performance-based approach in its review of DOE waste determinations and performance assessments to focus on the key natural and engineered system features needed to support its compliance

  6. 78 FR 30384 - Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory Fairness Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... ADMINISTRATION Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory Fairness Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open meeting of the Regional (Region X) Small... requested. Anyone wishing to attend and/or make a presentation to the Region X Regulatory Fairness...

  7. 78 FR 36011 - Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... ADMINISTRATION Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open meeting of the Regional (Region VII) Small... Region VII Regulatory Fairness Board must contact Jeanna Trenkamp by June 17, 2013 in writing, by fax...

  8. Current and future applications of PRA in regulatory activities

    SciTech Connect

    Speis, T.P.; Murphy, J.A.; Cunningham, M.A.

    1995-04-01

    Probabilistic Risk Assessments (PRAs) have proven valuable in providing the regulators, the nuclear plant operators, and the reactor designers insights into plant safety, reliability, design and operation. Both the NRC Commissioners and the staff have grown to appreciate the valuable contributions PRAs can have in the regulatory arena, though I will admit the existence of some tendencies for strict adherence to the deterministic approach within the agency and the public at large. Any call for change, particularly one involving a major adjustment in approach to the regulation of nuclear power, will meet with a certain degree of resistance and retrenchment. Change can appear threatening and can cause some to question whether the safety mission is being fulfilled. This skepticism is completely appropriate and is, in fact, essential to a proper transition towards risk and performance-based approaches. Our task in the Office of Nuclear Regulatory Research is to increase the PRA knowledge base within the agency and develop appropriate guidance and methods needed to support the transitioning process.

  9. Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements

    PubMed Central

    Mayho, Matthew; Fenn, Katelyn; Craddy, Paul; Crosthwaite, Susan; Matthews, Keith

    2006-01-01

    Trypanosomes represent an excellent model for the post-transcriptional regulation of gene expression because their genome is organized into polycistronic transcription units. However, few signals governing developmental stage-specific expression have been identified, with there being no compelling evidence for widespread conservation of regulatory motifs. As a tool to search for common regulatory sequences we have used the nuclear-encoded components of the cytochrome oxidase (COX) complex of the trypanosome respiratory chain. Components of this complex represent a form of post-transcriptional operon because trypanosome mitochondrial activity is unusual in being developmentally programmed. By genome analysis we identified the genes for seven components of the COX complex. Each mRNA exhibits bloodstream stage-specific instability, which is not mediated by the RNA silencing pathway but which is alleviated by cycloheximide. Reporter assays have identified regulatory regions within the 3′-untranslated regions of three COX mRNAs operating principally at the translational level, but also via mRNA stability. Interrogation of the mapped regions via oligonucleotide frequency scoring provides evidence for genome-wide conservation of regulatory sequences among a large cohort of procyclic-enriched transcripts. Analysis of the co-regulated subunits of a stage-specific enzyme is therefore a novel approach to uncover cryptic regulatory sequences controlling gene expression at the post-transcriptional level. PMID:17012283

  10. Comparison of Standard Light Water Reactor Cross-Section Libraries using the United States Nuclear Regulatory Commission Pressurized Water Reactor Standard Core Loading Benchmark Problem

    NASA Astrophysics Data System (ADS)

    Arzu Alpan, F.; Kulesza, Joel A.

    2016-02-01

    This paper compares contemporary and historical light water reactor shielding and pressure vessel dosimetry cross-section libraries for a pressurized water reactor calculational benchmark problem with a standard out-in core loading. The calculational benchmark problem was developed at Brookhaven National Laboratory by the request of the U. S. Nuclear Regulatory Commission and used the Oak Ridge National Laboratory two-dimensional discrete ordinates code DORT and the BUGLE-93 cross-section library for the calculations. In this paper, a Westinghouse three-dimensional discrete ordinates code with parallel processing, the RAPTOR-M3G code was used. A variety of cross section libraries were used with RAPTOR-M3G including the BUGLE-93, BUGLE-96, and BUGLE-B7 cross-section libraries developed at Oak Ridge National Laboratory, and the broad-group ALPAN-VII.0 cross-section library developed at Westinghouse. In comparing the calculation-to-calculation reaction rates using the BUGLE-93 cross-section library at the thermal shield, pressure vessel, and cavity capsules, for eleven dosimetry reaction rates, a maximum relative difference of 5% was observed, with the exception of 65Cu(n,2n) in the pressure vessel capsule that had a 90% relative difference with respect to the reference results. It is thought that the 65Cu(n,2n) reaction rate reported in the reference for the pressure vessel capsule is not correct. In considering the libraries developed after BUGLE-93, a maximum relative difference of 12% was observed in reaction rates, with respect to the reference results, for 237Np(n,f) in the cavity capsule using BUGLE-B7.

  11. 5 CFR 110.102 - What are Agency responsibilities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... posting location that best fits their physical layout. Agencies may supplement these postings with... managers and employees of regulatory changes based upon office layout, geographic dispersion of...

  12. 5 CFR 110.102 - What are Agency responsibilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... posting location that best fits their physical layout. Agencies may supplement these postings with... managers and employees of regulatory changes based upon office layout, geographic dispersion of...

  13. TANK OPERATIONS CONTRACT CONSTRUCTION MANAGEMENT METHODOLOGY UTILIZING THE AGENCY METHOD OF CONSTRUCTION MANAGEMENT TO SAFELY AND EFFECTIVELY COMPLETE NUCLEAR CONSTRUCTION WORK

    SciTech Connect

    LESO KF; HAMILTON HM; FARNER M; HEATH T

    2010-01-14

    Washington River Protection Solutions, LLC (WRPS) has faced significant project management challenges in managing Davis-Bacon construction work that meets contractually required small business goals. The unique challenge is to provide contracting opportunities to multiple small business construction subcontractors while performing high hazard work in a safe and productive manner. Previous to the Washington River Protection Solutions, LLC contract, Construction work at the Hanford Tank Farms was contracted to large companies, while current Department of Energy (DOE) Contracts typically emphasize small business awards. As an integral part of Nuclear Project Management at Hanford Tank Farms, construction involves removal of old equipment and structures and installation of new infrastructure to support waste retrieval and waste feed delivery to the Waste Treatment Plant. Utilizing the optimum construction approach ensures that the contractors responsible for this work are successful in meeting safety, quality, cost and schedule objectives while working in a very hazardous environment. This paper describes the successful transition from a traditional project delivery method that utilized a large business general contractor and subcontractors to a new project construction management model that is more oriented to small businesses. Construction has selected the Agency Construction Management Method. This method was implemented in the first quarter of Fiscal Year (FY) 2009, where Construction Management is performed by substantially home office resources from the URS Northwest Office in Richland, Washington. The Agency Method has allowed WRPS to provide proven Construction Managers and Field Leads to mentor and direct small business contractors, thus providing expertise and assurance of a successful project. Construction execution contracts are subcontracted directly by WRPS to small or disadvantaged contractors that are mentored and supported by DRS personnel. Each small

  14. 78 FR 26662 - Draft Supplement to the Generic Environmental Impact Statement for License Renewal of Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... action (license renewal) include no action and reasonable alternative energy sources. DATES: Submit...)) decision to vacate the NRC's Waste Confidence Decision Rule (75 FR 81032, 75 FR 81037) and provides... Plants; NextEra Energy Seabrook; Seabrook Station, Unit 1 AGENCY: Nuclear Regulatory Commission....

  15. Improving the regulation of safety at DOE nuclear facilities. Final report: Appendices

    SciTech Connect

    1995-12-01

    The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

  16. Improving the regulation of safety at DOE nuclear facilities. Final report

    SciTech Connect

    1995-12-01

    The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by DOE itself. The three major recommendations are: under any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

  17. International Atomic Energy Agency Bulletin, volume 22, no. 5 and 6

    NASA Astrophysics Data System (ADS)

    1980-10-01

    The assessment of benefits and risks associated with various energy sources and systems is considered in relation to human needs. Particular emphasis is given to occupational hazards connected with coal mining, the handling of natural and liquified petroleum gases, and the use of nuclear energy for electric power generation. A method of energy risk comparison is examined as well as the approach of a regulatory agency to the concept of risk. Reports of international conferences on the management of alpha contaminated waste and on plasma physics and controlled nuclear fusion research are included.

  18. 78 FR 1634 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Date FR Cite NPRM 02/00/13 Regulatory Flexibility Analysis Required: No. Agency Contact: Robert W... analysis is required, and the status of regulations previously reported. ADDRESSES: Director, for Internal... accessibility standards. Other amendments include updates to organizational information, use of the...

  19. 75 FR 79763 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... e mail communications. Timetable: Action Date FR Cite NPRM 04/00/11 NPRM Comment Period End 06/00/11... Medicaid EHR Incentive Programs. Timetable: Action Date FR Cite Interim Final Rule 01/13/10 75 FR 2014... 75 FR 44590 Regulatory Flexibility Analysis Required: No Agency Contact: Steven Posnack,...

  20. NEW MATERIALS DEVELOPED TO MEET REGULATORY AND TECHNICAL REQUIREMENTS ASSOCIATED WITH IN-SITU DECOMMISSIONING OF NUCLEAR REACTORS AND ASSOCIATED FACILITIES

    SciTech Connect

    Blankenship, J.; Langton, C.; Musall, J.; Griffin, W.

    2012-01-18

    For the 2010 ANS Embedded Topical Meeting on Decommissioning, Decontamination and Reutilization and Technology, Savannah River National Laboratory's Mike Serrato reported initial information on the newly developed specialty grout materials necessary to satisfy all requirements associated with in-situ decommissioning of P-Reactor and R-Reactor at the U.S. Department of Energy's Savannah River Site. Since that report, both projects have been successfully completed and extensive test data on both fresh properties and cured properties has been gathered and analyzed for a total of almost 191,150 m{sup 3} (250,000 yd{sup 3}) of new materials placed. The focus of this paper is to describe the (1) special grout mix for filling the P-Reactor vessel (RV) and (2) the new flowable structural fill materials used to fill the below grade portions of the facilities. With a wealth of data now in hand, this paper also captures the test results and reports on the performance of these new materials. Both reactors were constructed and entered service in the early 1950s, producing weapons grade materials for the nation's defense nuclear program. R-Reactor was shut down in 1964 and the P-Reactor in 1991. In-situ decommissioning (ISD) was selected for both facilities and performed as Comprehensive Environmental Response, Compensations and Liability Act actions (an early action for P-Reactor and a removal action for R-Reactor), beginning in October 2009. The U.S. Department of Energy concept for ISD is to physically stabilize and isolate intact, structurally robust facilities that are no longer needed for their original purpose of producing (reactor facilities), processing (isotope separation facilities), or storing radioactive materials. Funding for accelerated decommissioning was provided under the American Recovery and Reinvestment Act. Decommissioning of both facilities was completed in September 2011. ISD objectives for these CERCLA actions included: (1) Prevent industrial worker

  1. Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical Tissues

    PubMed Central

    Rollenhage, Christiane; Macura, Sherrill L.; Lathrop, Melissa J.; Mackenzie, Todd A.; Doncel, Gustavo F.; Asin, Susana N.

    2015-01-01

    Establishment of a productive HIV-1 infection in the female reproductive tract likely depends on the balance between anti-viral and pro-inflammatory responses leading to activation and proliferation of HIV target cells. Immune modulators that boost anti-viral and depress pro-inflammatory immune responses may decrease HIV-1 infection or replication. Polyinosinic:polycytidylic [Poly (I:C)] has been reported to down-regulate HIV-1 replication in immune cell subsets and lymphoid tissues, yet the scope and mechanisms of poly (I:C) regulation of HIV-1 replication in the cervicovaginal mucosa, the main portal of viral entry in women remain unknown. Using a relevant, underexplored ex vivo cervical tissue model, we demonstrated that poly (I:C) enhanced Interferon Regulatory Factor (IRF)7 mediated antiviral responses and decreased tissue Nuclear Factor Kappa B (NFκB) RNA expression. This pattern of cellular transcription factor expression correlated with decreased HIV-1 transcription and viral release. Reducing IRF7 expression up-regulated HIV-1 and NFκB transcription, providing proof of concept for the critical involvement of IRF7 in cervical tissues. By combining poly (I:C) with a suboptimal concentration of tenofovir, the leading anti-HIV prophylactic microbicide candidate, we demonstrated an earlier and greater decrease in HIV replication in poly (I:C)/tenofovir treated tissues compared with tissues treated with tenofovir alone, indicating overall improved efficacy. Poly (I:C) decreases HIV-1 replication by stimulating IRF7 mediated antiviral responses while reducing NFκB expression. Early during the infection, poly (I:C) improved the anti-HIV-1 activity of suboptimal concentrations of tenofovir likely to be present during periods of poor adherence i.e. inconsistent or inadequate drug use. Understanding interactions between anti-viral and pro-inflammatory immune responses in the genital mucosa will provide crucial insights for the identification of targets that can be

  2. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Regulatory review. 355.21 Section 355.21... AND REGULATIONS AFFECTING INTERSTATE MOTOR CARRIER OPERATIONS Requirements § 355.21 Regulatory review... review are provided in the appendix to this part. (b) Responsibility. The State agency designated as...

  3. 76 FR 54408 - Regulatory Review Schedule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    .... (76 FR 18457, April 4, 2011). The Commission's regulatory review process established a tribal... National Indian Gaming Commission 25 CFR Chapter III Regulatory Review Schedule AGENCY: National Indian..., 1441 L Street, NW., Suite 9100, Washington, DC 20005. Telephone: 202-632-7003; e-mail:...

  4. 76 FR 33181 - Regulatory Review Schedule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... processes. (76 FR 18457, April 4, 2011). The Commission's regulatory review process establishes a detailed... National Indian Gaming Commission 25 CFR Chapter III Regulatory Review Schedule AGENCY: National Indian... Notice of Consultation advising the public that the NIGC was conducting a comprehensive review of all...

  5. 76 FR 26967 - Regulatory Review Schedule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... National Indian Gaming Commission 25 CFR Chapter III Regulatory Review Schedule AGENCY: National Indian... advising the public that the NIGC was conducting a comprehensive review of its regulations and requesting public comment on the process for conducting the regulatory review. On April 4, 2011, after holding...

  6. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Regulatory review. 355.21 Section 355.21... AND REGULATIONS AFFECTING INTERSTATE MOTOR CARRIER OPERATIONS Requirements § 355.21 Regulatory review... review are provided in the appendix to this part. (b) Responsibility. The State agency designated as...

  7. 77 FR 8020 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... Agenda for the agency. SBA's last semiannual regulatory agenda was published on July 7, 2011, at 76 FR... Administration--Completed Actions Regulation Sequence No. Title Identifier No. 474 Implementation of Military... individual SBDC client data. Timetable: Action Date FR Cite ANPRM 06/00/12 Regulatory Flexibility...

  8. 78 FR 1570 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... January 8, 2013 Part VII Department of Energy Semiannual Regulatory Agenda #0;#0;Federal Register / Vol. 78 , No. 5 / Tuesday, January 8, 2013 / Unified Agenda#0;#0; ] DEPARTMENT OF ENERGY 10 CFR Chs. II, III, and X 48 CFR Ch. 9 Semiannual Regulatory Agenda AGENCY: Department of Energy. ACTION: Notice...

  9. Department of Interior Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...: Action Date FR Cite Final Action 04/00/10 Regulatory Flexibility Analysis Required: Yes Agency Contact... idle facilities. Timetable: Action Date FR Cite NPRM 12/00/10 NPRM Comment Period End 02/00/11... Part IX Department of the Interior Semiannual Regulatory Agenda ] DEPARTMENT OF THE INTERIOR...

  10. 76 FR 40208 - Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Date FR Cite NPRM 03/00/12 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Sean Harrison... Rule 506 of Regulation D. Timetable: Action Date FR Cite NPRM 06/01/11 76 FR 31518 NPRM Comment Period... by registrants. Timetable: Action Date FR Cite NPRM 03/00/12 Regulatory Flexibility Analysis...

  11. 76 FR 75798 - Reducing Regulatory Burden

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXIII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... its implementation of Executive Order 13563, ``Improving Regulation and Regulatory Review,'' issued by... General Counsel for Legislation, Regulation, and Energy Efficiency, U.S. Department of Energy, Office...

  12. 78 FR 1646 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ...This agenda provides summary descriptions of regulations being developed by the Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council in compliance with Executive Order 12866 ``Regulatory Planning and Review.'' This agenda is being published to allow interested persons an opportunity to participate in the rulemaking process. The Regulatory Secretariat Division has......

  13. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Regulatory review. 355.21 Section 355.21... AND REGULATIONS AFFECTING INTERSTATE MOTOR CARRIER OPERATIONS Requirements § 355.21 Regulatory review... review are provided in the appendix to this part. (b) Responsibility. The State agency designated as...

  14. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Regulatory review. 355.21 Section 355.21... AND REGULATIONS AFFECTING INTERSTATE MOTOR CARRIER OPERATIONS Requirements § 355.21 Regulatory review... review are provided in the appendix to this part. (b) Responsibility. The State agency designated as...

  15. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Regulatory review. 355.21 Section 355.21... AND REGULATIONS AFFECTING INTERSTATE MOTOR CARRIER OPERATIONS Requirements § 355.21 Regulatory review... review are provided in the appendix to this part. (b) Responsibility. The State agency designated as...

  16. Environmental Regulatory Update Table, August 1991

    SciTech Connect

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental Regulatory Update Table, October 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental Regulatory Update Table, December 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. Environmental Regulatory Update Table, April 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  20. Environmental Regulatory Update Table, November 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. Environmental Regulatory Update Table, December 1989

    SciTech Connect

    Houlbert, L.M.; Langston, M.E. ); Nikbakht, A.; Salk, M.S. )

    1990-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  2. Environmental Regulatory Update Table, September 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  3. Environmental Regulatory Update Table, December 1990

    SciTech Connect

    Hawkins, G.T.; Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1991-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  4. Environmental Regulatory Update Table, November 1990

    SciTech Connect

    Hawkins, G.T.; Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1990-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Environmental Regulatory Update Table, October 1990

    SciTech Connect

    Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1990-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental Regulatory Update Table, September 1990

    SciTech Connect

    Houlberg, L.M.; Nikbakht, A.; Salk, M.S.

    1990-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Environmental regulatory update table, July 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-08-01

    This Environmental Regulatory Update Table (July 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental regulatory update table, March 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Sabotage at Nuclear Power Plants

    SciTech Connect

    Purvis, James W.

    1999-07-21

    Recently there has been a noted worldwide increase in violent actions including attempted sabotage at nuclear power plants. Several organizations, such as the International Atomic Energy Agency and the US Nuclear Regulatory Commission, have guidelines, recommendations, and formal threat- and risk-assessment processes for the protection of nuclear assets. Other examples are the former Defense Special Weapons Agency, which used a risk-assessment model to evaluate force-protection security requirements for terrorist incidents at DOD military bases. The US DOE uses a graded approach to protect its assets based on risk and vulnerability assessments. The Federal Aviation Administration and Federal Bureau of Investigation conduct joint threat and vulnerability assessments on high-risk US airports. Several private companies under contract to government agencies use formal risk-assessment models and methods to identify security requirements. The purpose of this paper is to survey these methods and present an overview of all potential types of sabotage at nuclear power plants. The paper discusses emerging threats and current methods of choice for sabotage--especially vehicle bombs and chemical attacks. Potential consequences of sabotage acts, including economic and political; not just those that may result in unacceptable radiological exposure to the public, are also discussed. Applicability of risk-assessment methods and mitigation techniques are also presented.

  10. 78 FR 13656 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Information Administration Agency Information Collection Extension AGENCY: U.S. Energy Information... Act of 1995, an information collection request to the OMB for a three-year extension, with changes, of... should be sent to the: DOE Desk Officer, Office of Information and Regulatory Affairs, Office...

  11. 76 FR 38380 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... Efficiency and Renewable Energy Proposed Agency Information Collection AGENCY: Energy Efficiency and... clearance, a proposal for collection of information under the provisions of the Paperwork Reduction Act of... Officer, Office of Information and Regulatory Affairs, Office of Management and Budget, New...

  12. Educational Activities At The Nuclear Engineering Teaching Laboratory

    NASA Astrophysics Data System (ADS)

    Tipping, Tracy N.

    2011-06-01

    The Nuclear Engineering Teaching Laboratory (NETL) at the University of Texas at Austin performs a wide variety of educational activities for students at various levels. Regular on-site courses in the areas of health physics, radiochemistry, and reactor operations are offered for university credit. Along with on-site courses, access to the reactor facility via a remote console connection allows students in an off-site classroom to conduct experiments via a "virtual" control console. In addition to the regularly scheduled courses, other programs, such as the Nuclear Regulatory Commission Summer Nuclear Engineering Institute and Office of Naval Research partnerships with Historically Black Colleges and Universities, provide access to the facility for students from other universities both domestic and foreign. And NETL hosts professional development programs such as training programs for Nuclear Regulatory Commission personnel and International Atomic Energy Agency fellowships.

  13. A Systematic Approach to Child Care Regulatory Review, Policy Evaluation and Planning To Promote Health and Safety of Children in Child Care: A Manual for State and Local Child Care and Maternal and Child Health Agency Staff.

    ERIC Educational Resources Information Center

    Griffin, Abbey; Fiene, Richard

    This manual is written for state and local administrators and statewide child care and child health organizations looking for ways to improve the efficiency and effectiveness of their child care regulatory review, rule-making process, and enforcement system. Data collection procedures and a review team process, state administrators can identify…

  14. ALARA at nuclear power plants

    SciTech Connect

    Baum, J.W.

    1990-01-01

    Implementation of the As Low As Reasonably Achievable (ALARA) principle at nuclear power plants presents a continuing challenge for health physicists at utility corporate and plant levels, for plant designers, and for regulatory agencies. The relatively large collective doses at some plants are being addressed though a variety of dose reduction techniques. It is planned that this report will include material on historical aspects, management, valuation of dose reduction, quantitative and qualitative aspects of optimization, design, operational considerations, and training. The status of this work is summarized in this report. 30 refs., 1 fig., 6 tabs.

  15. 78 FR 46617 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Register on November 27, 2012 (77 FR 70843). The supplements had no effect on the no significant hazards... the Containment Structure for Additional Electrical Penetration Assemblies AGENCY: Nuclear Regulatory... amendments that the application complies with the standards and requirements of the Atomic Energy Act of...

  16. 78 FR 64029 - Cost-Benefit Analysis for Radwaste Systems for Light-Water-Cooled Nuclear Power Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... COMMISSION Cost-Benefit Analysis for Radwaste Systems for Light-Water-Cooled Nuclear Power Reactors AGENCY... Commission (NRC) is issuing revision 1 to Regulatory Guide (RG) 1.110, ``Cost-Benefit Analysis for Radwaste... methods and procedures that the staff of the NRC considers acceptable for performing a...

  17. 78 FR 45987 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... Register on February 19, 2013 (78 FR 11693). The January 25, 2013 supplement revised the original no... the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined..., located in Burke County, Georgia. The amendment requests to modify the Primary Sampling System...

  18. 78 FR 45989 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... Register on February 19, 2013 (78 FR 11693). The January 25, 2013 supplement revised the original no... the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined..., located in Burke County, Georgia. The amendment requests to modify the Primary Sampling System...

  19. 78 FR 50455 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Changes to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... actions, was published in the Federal Register on March 4, 2013 (78 FR 14137). The supplements had no... the Chemical Volume Control System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and... Control System (CVS), including changes to information located in Tier 1 Tables 2.3.2- 1 and 2.3.2-2,...

  20. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...