Science.gov

Sample records for agency rtp nc

  1. PARTICLE SIZE DISTRIBUTIONS FROM SELECT RESIDENCES PARTICIPATING IN THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    Particle Size Distributions from Select Residences Participating in the NERL RTP PM Panel Study. Alan Vette, Ronald Williams, and Michael Riediker, U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, NC 27711; Jonathan Thornburg...

  2. STATUS OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY'S ENCODRINE DISRUPTOR SCREENING PROGRAM

    EPA Science Inventory

    Status of the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program. Susan Laws. Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. EPA, RTP, NC.

    In response to emergi...

  3. EPA/ORD/RTP (Environmental Protection Agency, Office of Research and Development, Research Triangle Park) asbestos program support for the OTS (Office of Toxic Substances) asbestos-in-schools program. Final report

    SciTech Connect

    Beard, M.E.

    1986-03-01

    An overview of the EPA/ORD/RTP Asbestos program support for the OTS Asbestos-in-Schools Program is given. The program includes (1) a bulk sample asbestos analysis audit program, (2) an intercomparison of three measurement methods for airborne asbestos, (3) the development of audit materials for airborne asbestos measurement methods, and (4) the development of guidance for post-abatement asbestos air monitoring.

  4. A novel implement of RTP over EPON

    NASA Astrophysics Data System (ADS)

    Zhu, Jiyan; Liu, Deming; Lu, Xi

    2005-11-01

    In this article we present our new implementation of Real-time transport protocol (RTP) with its control protocol (RTCP) which enables the real-time delivery of continuous and interactive media over an emerging access network -Ethernet passive optical networks. RTP can provide end-to-end delivery service for data with real-time characteristics, such as interactive audio and video. While RTP is primarily designed to satisfy the needs of multiparticipant multimedia conferences, it is not limited to that particular application. Now we can use it for multimedia delivery over EPON, which represent the convergence of low-cost Ethernet equipment and low-cost fiber infrastructure, appear to be the best candidate for the next-generation access network. Ethernet passive optical networks are an emerging access network technology that provides a low-cost method of deploying optical access lines between a carrier's central office (co) and a customer site. RTP application designers are advised to avoid mechanisms that can only work in unicast mode and will not scale to larger number. Because of some characteristics of EPON architecture, we develop a new RTP which is suitable for this architecture.

  5. 78 FR 54947 - Notice of Final Federal Agency Actions on Proposed US 1 Improvements-Rockingham, Richmond County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... County, NC ] from Sandhill Road (SR 1971) to Marston Road (SR 1001). Those actions grant licenses... proposed action will improve 19 miles of US 1 from Sandhill Road (SR 1971) south of Rockingham to Marston... on new location, and widens about five miles of existing US 1. From Sandhill Road (SR 1971) to...

  6. Plasma filamentation in the Rijnhuizen tokamak RTP

    SciTech Connect

    Lopes Cardozo, N.J.; Schueller, F.C.; Barth, C.J.; Chu, C.C.; Pijper, F.J.; Lok, J.; Oomens, A.A.M. )

    1994-07-11

    Evidence for small scale magnetic structures in the Rijnhuizen tokamak RTP is presented. These are manifest through steps and peaks in the electron temperature and pressure, measured with multiposition Thomson scattering. During central electron cyclotron heating, several filaments of high pressure are found in the power deposition region. They live hundreds of microseconds. Near the sawtooth inversion radius a step'' in the temperature profile occurs. Further out, quasiperiodic structures are observed, in both Ohmic and heated discharges.

  7. Reaping the benefits of RTP: Georgia Power`s RTP evaluation case study, Volumes 1 and 2. Final report

    SciTech Connect

    King, K.; Armstrong, D.; Baladi, S.M.

    1995-12-01

    The objective of this report is to assist utilities that are considering real-time pricing (RTP) programs by documenting Georgia Power`s experience with RTP. This report will help utilities better understand both the benefits and the necessary steps of RTP implementation. Real-time pricing is the product that utilities are turning to in order to position themselves for a more competitive market because as the electric utility industry becomes more competitive, customers will demand differentiated products that enable them to use electricity more efficiently and economically, and utilities will seek products that give them the flexibility to profitably meet customer needs. This two-volume report examines the development, implementation, and evaluation of RTP at Georgia Power. Its primary focus is on the pilot program period. The first volume discusses the service design employed at Georgia Power and presents the various stages in the implementation of RTP. It contains information on the design of RTP, the estimation of future marginal costs, and the management and support of RTP. The second volume evaluates customer satisfaction and load response. It contains discussions on initial simulated customer response, results from an RTP customer satisfaction survey, an econometric analysis of customer response, and incorporating customer response to RTP into price forecasting and system planning.

  8. The characteristic assessment of spent ion exchange resin from PUSPATI TRIGA REACTOR (RTP) for immobilization process

    SciTech Connect

    Wahida, Nurul; Yasir, Muhamad Samudi; Majid, Amran Ab; Irwan, M. N.; Wahab, Mohd Abd; Marzukee, Nik; Paulus, Wilfred; Phillip, Esther; Thanaletchumy

    2014-09-03

    In this paper, spent ion exchange resin generated from PUSPATI TRIGA reactor (RTP) in Malaysian Nuclear Agency were characterized based on the water content, radionuclide content and radionuclide leachability. The result revealed that the water content in the spent resin is 48%. Gamma spectrometry analysis indicated the presence of {sup 134}Cs, {sup 137}Cs, {sup 152}Eu, {sup 54}Mn, {sup 58}Co, {sup 60}Co and {sup 65}Zn. The leachability test shows a small concentrations (<1 Bq/l) of {sup 152}Eu and {sup 134}Cs were leached out from the spent resin while {sup 60}Co activity concentrations slightly exceeded the limit generally used for industrial wastewater i.e. 1 Bq/l. Characterization of spent ion exchange resin sampled from RTP show that this characterization is important as a basis to immobilize this radioactive waste using geopolymer technology.

  9. Core Calculation of 1 MWatt PUSPATI TRIGA Reactor (RTP) using Monte Carlo MVP Code System

    SciTech Connect

    Karim, Julia Abdul

    2008-05-20

    The Monte Carlo MVP code system was adopted for the Reaktor TRIGA PUSAPTI (RTP) core calculation. The code was developed by a group of researcher of Japan Atomic Energy Agency (JAEA) first in 1994. MVP is a general multi-purpose Monte Carlo code for neutron and photon transport calculation and able to estimate an accurate simulation problems. The code calculation is based on the continuous energy method. This code is capable of adopting an accurate physics model, geometry description and variance reduction technique faster than conventional method as compared to the conventional scalar method. This code could achieve higher computational speed by several factors on the vector super-computer. In this calculation, RTP core was modeled as close as possible to the real core and results of keff flux, fission densities and others were obtained.

  10. The characteristic assessment of spent ion exchange resin from PUSPATI TRIGA REACTOR (RTP) for immobilization process

    NASA Astrophysics Data System (ADS)

    Wahida, Nurul; Yasir, Muhamad Samudi; Majid, Amran Ab; Wahab, Mohd Abd; Marzukee, Nik; Paulus, Wilfred; Phillip, Esther; Thanaletchumy, Irwan, M. N.

    2014-09-01

    In this paper, spent ion exchange resin generated from PUSPATI TRIGA reactor (RTP) in Malaysian Nuclear Agency were characterized based on the water content, radionuclide content and radionuclide leachability. The result revealed that the water content in the spent resin is 48%. Gamma spectrometry analysis indicated the presence of 134Cs, 137Cs, 152Eu, 54Mn, 58Co, 60Co and 65Zn. The leachability test shows a small concentrations (<1 Bq/l) of 152Eu and 134Cs were leached out from the spent resin while 60Co activity concentrations slightly exceeded the limit generally used for industrial wastewater i.e. 1 Bq/l. Characterization of spent ion exchange resin sampled from RTP show that this characterization is important as a basis to immobilize this radioactive waste using geopolymer technology.

  11. Airborne ocean water lidar (OWL) real time processor (RTP)

    NASA Astrophysics Data System (ADS)

    Hryszko, M.

    1995-03-01

    The Hyperflo Real Time Processor (RTP) was developed by Pacific-Sierra Research Corporation as a part of the Naval Air Warfare Center's Ocean Water Lidar (OWL) system. The RTP was used for real time support of open ocean field tests at Barbers Point, Hawaii, in March 1993 (EMERALD I field test), and Jacksonville, Florida, in July 1994 (EMERALD I field test). This report describes the system configuration, and accomplishments associated with the preparation and execution of these exercises. This document is intended to supplement the overall test reports and provide insight into the development and use of the PTP. A secondary objective is to provide basic information on the capabilities, versatility and expandability of the Hyperflo RTP for possible future projects. It is assumed herein that the reader has knowledge of the OWL system, field test operations, general lidar processing methods, and basic computer architecture.

  12. COARSE PARTICULATE MATTER CONCENTRATIONS FROM RESIDENTIAL OUTDOOR SITES ASSOCIATED WITH THE NORTH CAROLINA ASTHMA AND CHILDREN'S ENVIRONMENT STUDIES (NC - ACES)

    EPA Science Inventory

    Residential outdoor monitoring was performed at 26 homes in the RTP area of NC from September 2003 to June 2004. PM10-2.5 values were estimated using the differential between independent PM10 and PM2.5 collocated MiniVol measurements. The dichot...

  13. EPA/IERL-RTP PILOT ELECTROSTATIC PRECIPITATOR - SELECTED EXPERIMENTS, 1978

    EPA Science Inventory

    The report describes experiments with a pilot-scale electrostatic precipitator (ESP) at EPA/IERL-RTP. The ESP is a dedicated experimental tool, operated for experiments originated and designed both in-house and by EPA contractors. Five distinct test series, between March and Octo...

  14. Neutron flux and power in RTP core-15

    NASA Astrophysics Data System (ADS)

    Rabir, Mohamad Hairie; Zin, Muhammad Rawi Md; Usang, Mark Dennis; Bayar, Abi Muttaqin Jalal; Hamzah, Na'im Syauqi Bin

    2016-01-01

    PUSPATI TRIGA Reactor achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. This paper describes the reactor parameters calculation for the PUSPATI TRIGA REACTOR (RTP); focusing on the application of the developed reactor 3D model for criticality calculation, analysis of power and neutron flux distribution of TRIGA core. The 3D continuous energy Monte Carlo code MCNP was used to develop a versatile and accurate full model of the TRIGA reactor. The model represents in detailed all important components of the core with literally no physical approximation. The consistency and accuracy of the developed RTP MCNP model was established by comparing calculations to the available experimental results and TRIGLAV code calculation.

  15. Concurrent design of an RTP chamber and advanced control system

    SciTech Connect

    Spence, P.; Schaper, C.; Kermani, A.

    1995-12-31

    A concurrent-engineering approach is applied to the development of an axisymmetric rapid-thermal-processing (RTP) reactor and its associated temperature controller. Using a detailed finite-element thermal model as a surrogate for actual hardware, the authors have developed and tested a multi-input multi-output (MIMO) controller. Closed-loop simulations are performed by linking the control algorithm with the finite-element code. Simulations show that good temperature uniformity is maintained on the wafer during both steady and transient conditions. A numerical study shows the effect of ramp rate, feedback gain, sensor placement, and wafer-emissivity patterns on system performance.

  16. RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.

    PubMed

    Martín-Flores, Núria; Romaní-Aumedes, Joan; Rué, Laura; Canal, Mercè; Sanders, Phil; Straccia, Marco; Allen, Nicholas D; Alberch, Jordi; Canals, Josep M; Pérez-Navarro, Esther; Malagelada, Cristina

    2016-07-01

    RTP801 expression is induced by cellular stress and has a pro-apoptotic function in non-proliferating differentiated cells such as neurons. In several neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease, elevated levels of RTP801 have been observed, which suggests a role for RTP801 in neuronal death. Neuronal death is also a pathological hallmark in Huntington's disease (HD), an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Currently, the exact mechanisms underlying mutant huntingtin (mhtt)-induced toxicity are still unclear. Here, we investigated whether RTP801 is involved in (mhtt)-induced cell death. Ectopic exon-1 mhtt elevated RTP801 mRNA and protein levels in nerve growth factor (NGF)-differentiated PC12 cells and in rat primary cortical neurons. In neuronal PC12 cells, mhtt also contributed to RTP801 protein elevation by reducing its proteasomal degradation rate, in addition to promoting RTP801 gene expression. Interestingly, silencing RTP801 expression with short hairpin RNAs (shRNAs) blocked mhtt-induced cell death in NGF-differentiated PC12 cells. However, RTP801 protein levels were not altered in the striatum of Hdh(Q7/Q111) and R6/1 mice, two HD models that display motor deficits but not neuronal death. Importantly, RTP801 protein levels were elevated in both neural telencephalic progenitors differentiated from HD patient-derived induced pluripotent stem cells and in the putamen and cerebellum of human HD postmortem brains. Taken together, our results suggest that RTP801 is a novel downstream effector of mhtt-induced toxicity and that it may be relevant to the human disease. PMID:25876513

  17. 75 FR 4269 - Establishment of Class E Airspace; Hertford, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Hertford, NC AGENCY... September 14, 2009 that establishes Class E Airspace at Harvey Point Defense Testing Activity, Hertford, NC... (74 FR 46892), Docket No. FAA-2009-0705; Airspace Docket No. 09-ASO-25. The FAA uses the direct...

  18. 76 FR 55555 - Amendment of Class E Airspace; Shelby, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... Register a notice of proposed rulemaking to amend Class E airspace at Shelby, NC (76 FR 35799) Docket No..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Shelby, NC AGENCY:...

  19. TRAMP; The next generation data acquisition for RTP

    SciTech Connect

    van Haren, P.C.; Wijnoltz, F. )

    1992-04-01

    The Rijnhuizen Tokamak Project RTP is a medium-sized tokamak experiment, which requires a very reliable data-acquisition system, due to its pulsed nature. Analyzing the limitations of an existing CAMAC-based data-acquisition system showed, that substantial increase of performance and flexibility could best be obtained by the construction of an entirely new system. This paper discusses this system, CALLED TRAMP (Transient Recorder and Amoeba Multi Processor), based on tailor-made transient recorders with a multiprocessor computer system in VME running Amoeba. The performance of TRAMP exceeds the performance of the CAMAC system by a factor of four. The plans to increase the flexibility and for a further increase of performance are presented.

  20. RTP as an Optional Service: It's Alive, But Is It Well?

    SciTech Connect

    Goldman, Charles; Barbose, Galen; Neenan, Bernie

    2006-03-10

    Economists have advocated for real-time pricing (RTP) of electricity on the basis of the gains in economic efficiency that would result from charging customers the contemporaneous marginal cost of supplying electricity instead of the average cost. In recent years, RTP has also become the subject of interest in a variety of policy contexts, including integrated resource planning initiatives, ongoing efforts to improve efficiency and reliability in competitive electricity markets, and implementation of default service in states with retail choice. Most experience with RTP has been as an optional service, that is, a self-selecting alternative to the standard utility service. By our count, approximately 70 utilities in the U.S. offered an optional RTP program at some point over the past 20 years. However, many programs are now defunct. In 2003, 47 utilities in the U.S. were still offering an optional RTP program, on either a pilot or permanent basis (see Figure 1). In addition, 10 utilities in states with retail choice currently offer RTP as the default service for large customers that are not under contract with a competitive supplier. Another two utilities have received regulatory approval to do so in the next few years. Although the results of a few optional RTP programs have been publicized, the vast majority of programs have operated in relative obscurity. To provide a wider perspective on utility and customer experience with RTP, we surveyed 43 optional RTP programs offered in 2003. We interviewed RTP program managers and other utility staff, and reviewed publicly available sources, including key regulatory documents and program evaluations. Based on this research, we identified trends related to RTP program history and outlook, program design and implementation, customer participation, and participant price response. The results are both surprising and instructive. We conclude that RTP is indeed alive but is not prospering as well it could. Thus, we offer a

  1. 77 FR 64411 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway (AIWW), Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ...), Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of deviation from drawbridge regulation.... 74 Bridge across the Atlantic Intracoastal Waterway, mile 283.1, at Wrightsville Beach, NC. The... Intracoastal Waterway (AIWW) mile 283.1, at Wrightsville Beach, NC has a vertical clearance of 20 feet,...

  2. 75 FR 52461 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ..., Wrightsville Beach, NC and Northeast Cape Fear River, Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice..., mile 283.1, at Wrightsville Beach, NC, and the Isabel S. Holmes Bridge across the Northeast Cape Fear... 283.1, at Wrightsville Beach and the Isabel S. Holmes Bridge across the Northeast Cape Fear...

  3. ( RTP, NC ) IMPROVING EMISSION INVENTORIES FOR EFFECTIVE AIR-QUALITY MANAGEMENT ACROSS NORTH AMERICA - A NARSTO ASSESSMENT

    EPA Science Inventory

    The NARSTO Ozone and Particulate Matter Assessments emphasized that emission inventories are critical to the success of air quality management programs and that emissions inventories in Canada, Mexico, and the United States need improvement to meet expectations for quality, timel...

  4. QA Activities on Two Large RARE Projects at the US EPA, RTP, NC ─ from Fish to Humans

    EPA Science Inventory

    Two RARE (Regional Applied Research Effort) projects are being managed by Janet Diliberto, Linda Birnbaum, and Thomas Hughes. Janet is the Project Officer, Linda is the science advisor and Thomas is the QA and Records Manager for these two RARE projects. These are high visibili...

  5. Rapid Thermal Processing (RTP) of semiconductors in space

    NASA Technical Reports Server (NTRS)

    Anderson, T. J.; Jones, K. S.

    1993-01-01

    The progress achieved on the project entitled 'Rapid Thermal Processing of Semiconductors in Space' for a 12 month period of activity ending March 31, 1993 is summarized. The activity of this group is being performed under the direct auspices of the ROMPS program. The main objective of this program is to develop and demonstrate the use of advanced robotics in space with rapid thermal process (RTP) of semiconductors providing the test technology. Rapid thermal processing is an ideal processing step for demonstration purposes since it encompasses many of the characteristics of other processes used in solid state device manufacturing. Furthermore, a low thermal budget is becoming more important in existing manufacturing practice, while a low thermal budget is critical to successful processing in space. A secondary objective of this project is to determine the influence of microgravity on the rapid thermal process for a variety of operating modes. In many instances, this involves one or more fluid phases. The advancement of microgravity processing science is an important ancillary objective.

  6. RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

    PubMed Central

    Canal, Mercè; Romaní-Aumedes, Joan; Martín-Flores, Núria; Pérez-Fernández, Víctor; Malagelada, Cristina

    2014-01-01

    Mechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy. Importantly, mTOR pathway deregulation has been related to many diseases. Indeed, it has become a hallmark in neurodegenerative disorders, since a fine-tuned regulation of mTOR activities is crucial for neuron function and survival. RTP801/REDD1/Dig2 has become one of the most puzzling regulators of mTOR. Although the mechanism is not completely understood, RTP801 inactivates mTOR and Akt via the tuberous sclerosis complex (TSC1/TSC2) in many cellular contexts. Intriguingly, RTP801 protects dividing cells from hypoxia or H2O2-induced apoptosis, while it sensitizes differentiated cells to stress. Based on experimental models of Parkinson’s disease (PD), it has been proposed that at early stages of the disease, stress-induced RTP801 upregulation contributes to mTOR repression, in an attempt to maintain cell function and viability. However, if RTP801 elevation is sustained, it leads to neuron cell death by a sequential inhibition of mTOR and Akt. Here, we will review RTP801 deregulation of mTOR in a context of PD and other neurodegenerative disorders. PMID:25324725

  7. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.

    PubMed

    Cheng, Shu-Yuan; Oh, Seon; Velasco, Marcela; Ta, Christine; Montalvo, Jessica; Calderone, Alyssa

    2014-07-01

    Environmental factors have been implicated in the pathogenesis of neurodegenerative diseases. Maneb (MB) and mancozeb (MZ) have been extensively used as pesticides. Exposure to MB lowers the threshold for dopaminergic damage triggered by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. MB and MZ potentiate 1-methyl-4-phenylpyridium (MPP(+))-induced cytotoxicity in rat pheochromocytoma (PC12) cells partially via nuclear factor kappa B (NF-κB) activation. RTP801 dramatically increased by oxidative stresses and DNA damage is the possible mechanism of neurotoxins-induced cell death in many studies. This study demonstrated that MB and MZ induced DNA damage as seen in comet assay. The expressions of RTP801 protein and mRNA were elevated after MB and MZ exposures. By knocking down RTP801 using shRNA, we demonstrated that NF-κB activation by MB and MZ was regulated by RTP801 and cell death triggered by MB and MZ was associated with RTP801 elevation. This revealed that the toxic mechanisms of dithiocarbamates are via the cross talk between RTP801 and NF-κB. PMID:24764117

  8. Quinolinic acid induces cell apoptosis in PC12 cells through HIF-1-dependent RTP801 activation.

    PubMed

    Huang, Xiaojia; Yang, Kaiyong; Zhang, Yi; Wang, Qiang; Li, Yongjin

    2016-04-01

    Neurological disease comprises a series of disorders featuring brain dysfunction and neuronal cell death. Among the factors contributing to neuronal death, excitotoxicity induced by excitatory amino acids, such as glutamate, plays a critical role. However, the mechanisms about how the excitatory amino acids induce neuronal death remain elucidated. In this study, we investigated the role of HIF-1α (hypoxia inducible factor-1α) and RTP801 in cell apoptosis induced by quinolinic acid (QUIN), a glutamatergic agonist, in PC12 cells. We found that QUIN at 5 μM increased the expression of HIF-1α significantly with a peak at 24 h. After the treatment with QUIN (5-20 μM) for 24 h, the cells exhibited decreased viability and cell apoptosis with a concomitant increased expression of apoptosis related proteins. QUIN treatment also induced the generation of intracellular reactive oxygen species and RTP801 up-regulation in a HIF-1α-dependent manner that were inhibited by 2-methoxyestradiol, a HIF-1α inhibitor. Importantly, HIF-1 or RTP801 invalidation by siRNA rescued the cell apoptosis induced by QUIN or cobalt chloride, a chemical inducer of HIF-1. Taken together, these findings support the concept that neurotoxicity induced by QUIN is associated with HIF-1-dependent RTP801 activation and provide insight into the potential of RTP801 inhibitor in treatment of neurological disorders. PMID:26738727

  9. RTP1 encodes a novel endoplasmic reticulum (ER)-localized protein in Arabidopsis and negatively regulates resistance against biotrophic pathogens.

    PubMed

    Pan, Qiaona; Cui, Beimi; Deng, Fengyan; Quan, Junli; Loake, Gary J; Shan, Weixing

    2016-03-01

    Oomycete pathogens cause serious damage to a wide spectrum of plants. Although host pathogen recognition via pathogen effectors and cognate plant resistance proteins is well established, the genetic basis of host factors that mediate plant susceptibility to oomycete pathogens is relatively unexplored. Here, we report on RTP1, a nodulin-related MtN21 family gene in Arabidopsis that mediates susceptibility to Phytophthora parasitica. RTP1 was identified by screening a T-DNA insertion mutant population and encoded an endoplasmic reticulum (ER)-localized protein. Overexpression of RTP1 rendered Arabidopsis more susceptible, whereas RNA silencing of RTP1 led to enhanced resistance to P. parasitica. Moreover, an RTP1 mutant, rtp1-1, displayed localized cell death, increased reactive oxygen species (ROS) production and accelerated PR1 expression, compared to the wild-type Col-0, in response to P. parasitica infection. rtp1-1 showed a similar disease response to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) DC3000, including increased disease resistance, cell death and ROS production. Furthermore, rpt1-1 exhibited resistance to the fungal pathogen Golovinomyces cichoracearum, but not to the necrotrophic pathogen Botrytis cinerea. Taken together, these results suggest that RTP1 negatively regulates plant resistance to biotrophic pathogens, possibly by regulating ROS production, cell death progression and PR1 expression. PMID:26484750

  10. MASS CONCENTRATION RELATIONSHIPS FROM THE NERL RTP PARTICULATE MATTER PANEL STUDY

    EPA Science Inventory

    The National Exposure Research Laboratory's (NERL) Research Triangle Park (RTP) Particulate Matter (PM) Panel Study has completed a one-year investigation of personal, residential and ambient PM-related mass concentrations in two potentially susceptible subpopulations. PM2.5, P...

  11. PRINCIPAL AQUIFERS, CURRENT POTENTIOMETRIC SURFACE MAPS, NC

    EPA Science Inventory

    Web page from North Carolina Department of Environment and Natural Resources (NC-DENR) to maps of potentiometric surfaces by aquifer in NC.
    http://www.dwr.ehnr.state.nc.us/hms/gwbranch/charact.htm

  12. SIGNIFICANT NATURAL HERITAGE AREAS (NC)

    EPA Science Inventory

    The North Carolina Department of Environment and Natural Resources, Division of Parks and Recreation, Natural Heritage Program in cooperation with the NC Center for Geographic Information & Analysis, developed the Significant Natural Heritage Areas digital data to determine the a...

  13. The Genome of the Novel Phage Rtp, with a Rosette-Like Tail Tip, Is Homologous to the Genome of Phage T1

    PubMed Central

    Wietzorrek, Andreas; Schwarz, Heinz; Herrmann, Christina; Braun, Volkmar

    2006-01-01

    Anew Escherichia coli phage, named Rtp, was isolated and shown to be closely related to phage T1. Electron microscopy revealed that phage Rtp has a morphologically unique tail tip consisting of four leaf-like structures arranged in a rosette, whereas phage T1 has thinner, flexible leaves that thicken toward the ends. In contrast to T1, Rtp did not require FhuA and TonB for infection. The 46.2-kb genome of phage Rtp encodes 75 open reading frames, 47 of which are homologous to phage T1 genes. Like phage T1, phage Rtp encodes a large number of small genes at the genome termini that exhibit no sequence similarity to known genes. Six predicted genes larger than 300 nucleotides in the highly homologous region of Rtp are not found in T1. Two predicted HNH endonucleases are encoded at positions different from those in phage T1. The sequence similarity of rtp37, -38, -39, -41, -42, and -43 to equally arranged genes of lambdoid phages suggests a common tail assembly initiation complex. Protein Rtp43 is homologous to the λ J protein, which determines λ host specificity. Since the two proteins differ most in the C-proximal area, where the binding site to the LamB receptor resides in the J protein, we propose that Rtp43 contributes to Rtp host specificity. Lipoproteins similar to the predicted lipoprotein Rtp45 are found in a number of phages (encoded by cor genes) in which they prevent superinfection by inactivating the receptors. We propose that, similar to the proposed function of the phage T5 lipoprotein, Rtp45 prevents inactivation of Rtp by adsorption to its receptor during cells lysis. Rtp52 is a putative transcriptional regulator, for which 10 conserved inverted repeats were identified upstream of genes in the Rtp genome. In contrast, the much larger E. coli genome has only one such repeat sequence. PMID:16452425

  14. 78 FR 12806 - North Carolina Disaster #NC-00048

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00048 AGENCY: U.S. Small Business Administration. ACTION: Notice... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  15. 77 FR 56250 - North Carolina Disaster #NC-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00044 AGENCY: U.S. Small Business Administration. ACTION: Notice... Deadline Date: 06/05/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  16. 76 FR 24554 - North Carolina Disaster Number NC-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... ADMINISTRATION North Carolina Disaster Number NC-00033 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State... INFORMATION: The notice of the Presidential disaster declaration for the State of North Carolina, dated...

  17. 78 FR 66983 - North Carolina Disaster #NC-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00057 AGENCY: U.S. Small Business Administration. ACTION: Notice... for the State of North Carolina (FEMA-4153-DR), dated 10/29/2013. Incident: Severe Storms,...

  18. 76 FR 66110 - North Carolina Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... ADMINISTRATION North Carolina Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 7. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the President's major disaster declaration for the State of North Carolina, dated...

  19. 77 FR 69692 - North Carolina Disaster #NC-00046

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... ADMINISTRATION North Carolina Disaster NC-00046 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of North Carolina... is 133828 and for economic injury is 133830. The State which received an EIDL Declaration is...

  20. 78 FR 61442 - North Carolina Disaster #NC-00056

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00056 AGENCY: U.S. Small Business Administration. ACTION: Notice... for the State of North Carolina (FEMA-4146-DR), dated 09/25/2013. Incident: Severe Storms,...

  1. 76 FR 56857 - North Carolina Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... ADMINISTRATION North Carolina Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State... INFORMATION: The notice of the Presidential disaster declaration for the State of North Carolina, dated...

  2. 75 FR 6737 - North Carolina Disaster # NC-00023

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00023 AGENCY: U.S. Small Business Administration. ACTION: Notice... for the State of North Carolina (FEMA-1871-DR), dated 02/02/2010. Incident: Severe Winter Storms...

  3. 76 FR 58559 - North Carolina Disaster Number NC-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... ADMINISTRATION North Carolina Disaster Number NC-00037 AGENCY: U.S. Small Business Administration. ACTION... Assistance Only for the State of North Carolina (FEMA-4019-DR), dated 09/01/2011. Incident: Hurricane Irene... Private Non-Profit organizations in the State of North Carolina, dated 09/01/2011, is hereby amended...

  4. 75 FR 11582 - North Carolina Disaster #NC-00023

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... ADMINISTRATION North Carolina Disaster NC-00023 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... Only for the State of North Carolina (FEMA--1871--DR), dated 02/02/2010. Incident: Severe Winter Storms... disaster declaration for Private Non-Profit organizations in the State of NORTH CAROLINA, dated...

  5. 77 FR 16313 - North Carolina Disaster #NC-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00043 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of North...

  6. 76 FR 38717 - North Carolina Disaster Number NC-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ... ADMINISTRATION North Carolina Disaster Number NC-00033 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the Presidential disaster declaration for the State of North Carolina, dated...

  7. 77 FR 4853 - North Carolina Disaster #NC-00041

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00041 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of NORTH...

  8. 76 FR 56855 - North Carolina Disaster Number NC-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... ADMINISTRATION North Carolina Disaster Number NC-00037 AGENCY: U.S. Small Business Administration. ACTION... Assistance Only for the State of North Carolina (FEMA-4019-DR), dated 09/01/2011. Incident: Hurricane Irene... Private Non-Profit organizations in the State of North Carolina, dated 09/01/2011, is hereby amended...

  9. 75 FR 30873 - North Carolina Disaster # NC-00027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... ADMINISTRATION North Carolina Disaster NC-00027 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of NORTH CAROLINA... injury is 12191 0. The State which received an EIDL Declaration is North Carolina (Catalog of...

  10. 76 FR 56856 - North Carolina Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... ADMINISTRATION North Carolina Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the Presidential disaster declaration for the State of North Carolina, dated...

  11. 76 FR 56856 - North Carolina Disaster Number NC-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... ADMINISTRATION North Carolina Disaster Number NC-00037 AGENCY: U.S. Small Business Administration. ACTION... Assistance Only for the State of North Carolina (FEMA-4019-DR), dated 09/01/2011. Incident: Hurricane Irene... Private Non-Profit organizations in the State of North Carolina, dated 09/01/2011, is hereby amended...

  12. 76 FR 64419 - NORTH CAROLINA Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... ADMINISTRATION NORTH CAROLINA Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 6. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the Presidential disaster declaration for the State of NORTH CAROLINA, dated...

  13. 76 FR 75597 - North Carolina Disaster #NC-00038

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... ADMINISTRATION North Carolina Disaster NC-00038 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of North Carolina.... The State which received an EIDL Declaration are North Carolina. (Catalog of Federal...

  14. 76 FR 38262 - North Carolina Disaster Number NC-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... ADMINISTRATION North Carolina Disaster Number NC-00033 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the President's major disaster declaration for the State of North Carolina, dated...

  15. 76 FR 56855 - North Carolina Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... ADMINISTRATION North Carolina Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...: The notice of the President's major disaster declaration for the State of North Carolina, dated...

  16. 76 FR 54523 - North Carolina Disaster #NC-00035

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00035 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of North...

  17. 78 FR 42148 - North Carolina Disaster #NC-00052

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00052 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of North...

  18. 76 FR 59180 - North Carolina Disaster Number NC-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... ADMINISTRATION North Carolina Disaster Number NC-00037 AGENCY: U.S. Small Business Administration. ACTION... Assistance Only for the State of North Carolina (FEMA-4019-DR), dated 09/01/2011. Incident: Hurricane Irene... Private Non-Profit organizations in the State of North Carolina, dated 09/01/2011, is hereby amended...

  19. 76 FR 28842 - North Carolina Disaster Number NC-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... ADMINISTRATION Disaster Declaration 12530 and 12531 North Carolina Disaster Number NC-00033 AGENCY: U.S. Small... declaration of a major disaster for the State of North Carolina (FEMA--1969-DR), dated 04/19/2011 . Incident... State of North Carolina, dated 04/19/2011 is hereby amended to include the following areas as...

  20. 75 FR 34365 - Safety Zone, Alligator River, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Alligator River, NC AGENCY: Coast Guard... the waters of the Alligator River at East Lake, North Carolina. The safety zone is intended to... on the Alligator River makes safety zone regulations necessary to provide for the safety...

  1. 75 FR 12688 - Safety Zone; Gallants Channel, Beaufort, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... establishes a temporary safety zone to protect the public from bridge maintenance operations. An environmental... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Gallants Channel, Beaufort, NC AGENCY... safety zone on the waters of Gallants Channel at Beaufort, North Carolina. The safety zone is...

  2. 76 FR 78331 - Environmental Impact Statement: Jackson County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Federal Highway Administration Environmental Impact Statement: Jackson County, NC AGENCY: Federal Highway... notice to advise the public that an environmental impact statement will be prepared for a proposed... Department of Transportation (NCDOT), will prepare an environmental impact statement (EIS) on the proposed...

  3. 76 FR 56860 - North Carolina Disaster #NC-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00037 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance...

  4. Fibronectin Binding to the Treponema pallidum Adhesin Protein Fragment rTp0483 on Functionalized Self-Assembled Monolayers

    PubMed Central

    Dickerson, Matthew T.; Abney, Morgan B.; Cameron, Caroline E.; Knecht, Marc; Bachas, Leonidas G.; Anderson, Kimberly W.

    2012-01-01

    Past work has shown that Treponema pallidum, the causative agent of syphilis, binds host fibronectin (FN). FN and other host proteins are believed to bind to rare outer membrane proteins (OMPs) of T. pallidum, and it is postulated that this interaction may facilitate cell attachment and mask antigenic targets on the surface. This research seeks to prepare a surface capable of mimicking the FN binding ability of T. pallidum in order to investigate the impact of FN binding with adsorbed Tp0483 on the host response to the surface. By understanding this interaction it may be possible to develop more effective treatments for infection and possibly mimic the stealth properties of the bacteria. Functionalized self-assembled monolayers (SAMs) on0 gold were used to investigate rTp0483 and FN adsorption. Using a quartz crystal microbalance (QCM) rTp0483 adsorption and subsequent FN adsorption onto rTp0483 was determined to be higher on negatively charged carboxylate-terminated self-assembled monolayers (−COO− SAMs) compared to the other surfaces analyzed. Kinetic analysis of rTp0483 adsorption using surface plasmon resonance (SPR) supported this finding. Kinetic analysis of FN adsorption using SPR revealed a multi-step event, where the concentration of immobilized rTp0483 plays a role in FN binding. An examination of relative QCM dissipation energy compared to the shift in frequency showed a correlation between the physical properties of adsorbed rTp0483 and SAM surface chemistry. In addition, AFM images of rTp0483 on selected SAMs illustrated a preference of rTp0483 to bind as aggregates. Adsorption on −COO− SAMs was more uniform across the surface, which may help further explain why FN bound more strongly. rTp0483 antibody studies suggested the involvement of amino acids 274–289 and 316–333 in binding between rTp0483 to FN, while a peptide blocking study only showed inhibition of binding with amino acids 316–333. Finally, surface adsorbed rTp0483 with FN

  5. Teach NC Basics Step by Step.

    ERIC Educational Resources Information Center

    Schroeder, Roger

    1978-01-01

    Rapid expansion of numerical control (NC) machining in industry has created the need for inclusion of NC basic concepts in the industrial education curriculum. The author describes an NC unit in an industrial technology class and the program sheet and NC worksheet that he developed for machining a product. (MF)

  6. PROCEEDINGS: INDUSTRY BRIEFING ON IERL-RTP LIME/LIMESTONE WET SCRUBBING TEST PROGRAMS (5TH) (DECEMBER 1979)

    EPA Science Inventory

    The proceedings document presentations made during the December 5, 1979, industry briefing conference which dealt with the status of EPA/IERL-RTP's flue gas desulfurization (FGD) research, development, and application programs. Subjects considered included: lime/limestone scrubbi...

  7. Conceptual design of fuel transfer cask for Reactor TRIGA PUSPATI (RTP)

    NASA Astrophysics Data System (ADS)

    Muhamad, Shalina Sheik; Hamzah, Mohd Arif Arif B.

    2014-02-01

    Spent fuel transfer cask is used to transfer a spent fuel from the reactor tank to the spent fuel storage or for spent fuel inspection. Typically, the cask made from steel cylinders that are either welded or bolted closed. The cylinder is enclosed with additional steel, concrete, or other material to provide radiation shielding and containment of the spent fuel. This paper will discuss the Conceptual Design of fuel transfer cask for Reactor TRIGA Puspati (RTP).

  8. Conceptual design of fuel transfer cask for Reactor TRIGA PUSPATI (RTP)

    SciTech Connect

    Muhamad, Shalina Sheik; Hamzah, Mohd Arif Arif B.

    2014-02-12

    Spent fuel transfer cask is used to transfer a spent fuel from the reactor tank to the spent fuel storage or for spent fuel inspection. Typically, the cask made from steel cylinders that are either welded or bolted closed. The cylinder is enclosed with additional steel, concrete, or other material to provide radiation shielding and containment of the spent fuel. This paper will discuss the Conceptual Design of fuel transfer cask for Reactor TRIGA Puspati (RTP)

  9. Novel developments in rapid thermal processing (RTP) temperature measurement and control

    NASA Astrophysics Data System (ADS)

    Adams, B. E.; Hunter, A. M.

    2013-09-01

    Since the development of integrated circuits in the 1960's, the semiconductor industry has continued to see the reduction of transistor size in accordance with Moore's law. Rapid thermal processing (RTP) has been an enabling technology for the continued evolution of these ultra-small devices. As thermal budgets have progressively dropped, equipment manufacturers have greatly increased the thermal ramp rates and reduced temperatures for many key processes. Lamp heated technology has developed sub-second dwell times and laser based systems have reduced processing time to milliseconds and shorter. This paper will highlight the key development in RTP temperature measurement and control for two distinct applications. The first is the development of temperature measurements of laser heated substrates. The work will discuss the unique challenges and requirements in this rapidly expanding processing space. These challenges arise from the very high background radiation from the laser sources, the extremely short dwell times, and the high processing temperatures. The second area under discussion is a solution to very low temperature silicon processes-primarily driven by Ni and NiPt silicides that have constrained thermal budgets, thus requiring high ramp rates and short dwell times, but in temperatures below the fundamental limits of standard radiation pyrometry. In particular, this work describes a novel system capable of measuring temperature down to room temperature in a state of the art RTP system.

  10. 78 FR 14543 - Ward Transformer Superfund Site; Raleigh, Wake County, NC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... AGENCY Ward Transformer Superfund Site; Raleigh, Wake County, NC; Notice of Settlement AGENCY... Agency has entered into a settlement at the Ward Transformer Superfund Site located in Raleigh, Wake... EPA Region 4 contact Ms. Paula V. Painter. Submit your comments by Site name Ward...

  11. UV - RESEARCH TRIANGLE PARK NC

    EPA Science Inventory

    Brewer 087 is located in Research Triangle Park NC, measuring ultraviolet solar radiation. Irradiance and column ozone are derived from this data. Ultraviolet solar radiation is measured with a Brewer Mark IV, single-monochrometer, spectrophotometer manufactured by SCI-TEC Instru...

  12. AmeriFlux US-NC1 NC_Clearcut

    SciTech Connect

    Noormets, Asko

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NC1 NC_Clearcut. Site Description - The North Carolina Clearcut site is located in a pine plantation amongst the mixed forests of the North Carolina lower coastal plain. Owned by the Weyerhaeuser Company, the plantation is managed for the purpose of commercial logging. In 2004, 70 ha of 75 year old native hardwoods was harvested. Following the clearcut, the stand was bedded and planted with loblolly pine seedlings. The only significant natural disturbances during the measurement period was a severe drought that lasted from summer of 2007 through 2008. Consequently, the 2007 total amount of precipitation was 486 mm below the 30-year norm.

  13. Research on RTP aeromagnetic gradient data and its applicability in different latitudes

    NASA Astrophysics Data System (ADS)

    Li, Lin; Guo, Hua; Wang, Ping; Jia, Wei-Jie

    2016-03-01

    Aeromagnetic gradient data needs to be reduced to the pole so that it can be better applied to geological interpretation through theoretical derivation. In this paper, we conduct research on the morphological characteristics of the total and horizontal gradient modules before and after reduction to the pole and design models at different latitudes, with consistent and inconsistent magnetic field direction and geological body magnetization direction. We discuss how to use the total gradient module and horizontal gradient module in geological interpretation. The reduced-to-the-pole (RTP) method is required for the horizontal gradient module method but not for the total gradient module. Finally, the conclusions derived from the theoretical models are verified through analysis of real data. The position determination of a geological body using the total gradient method, gradient data, or total-field data works better without RTP, ensuring data primitive authenticity. However, the horizontal gradient module should be reduced to the pole to determine the boundary of the geological body. Finally, the theoretical model is verified by actual data analysis. Both the total and horizontal gradient methods can be applied to geological interpretation.

  14. 76 FR 14970 - National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... AGENCY National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement AGENCY... National Starch and Chemical Company Site located in Mobile, Mobile County, Alabama for publication. DATES..., identified by Docket ID No. EPA-RO4- SFUND-2011-0278 or Site name National Starch and Chemical...

  15. 75 FR 81269 - Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... AGENCY Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements AGENCY... Ward Transformer Superfund Site located in Raleigh, Wake County, North Carolina for publication. DATES... your comments, identified by Docket ID No. EPA-RO4- SFUND-2010-1053 or Site name Ward...

  16. Optical/thermal analysis methodology for a space-qualifiable RTP furnace

    NASA Technical Reports Server (NTRS)

    Bugby, D.; Dardarian, S.; Cole, E.

    1993-01-01

    A methodology to predict the coupled optical/thermal performance of a reflective cavity heating system was developed and a laboratory test to verify the method was carried out. The procedure was utilized to design a rapid thermal processing (RTP) furnace for the Robot-Operated Material Processing in Space (ROMPS) Program which is a planned STS HH-G canister experiment involving robotics and material processing in microgravity. The laboratory test employed a tungsten-halogen reflector/lamp to heat thin, p-type silicon wafers. Measurements instrumentation consisted of 5-mil Pt/Pt-Rh thermocouples and an optical pyrometer. The predicted results, utilizing an optical ray-tracing program and a lumped-capacitance thermal analyzer, showed good agreement with the measured data for temperatures exceeding 1300 C.

  17. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear...) Except as provided elsewhere in this section from Cape Lookout to Cape Fear, lines drawn parallel...

  18. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear...) Except as provided elsewhere in this section from Cape Lookout to Cape Fear, lines drawn parallel...

  19. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  20. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  1. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  2. Hemisphere jet mass distribution at finite Nc

    NASA Astrophysics Data System (ADS)

    Hagiwara, Yoshikazu; Hatta, Yoshitaka; Ueda, Takahiro

    2016-05-01

    We perform the leading logarithmic resummation of nonglobal logarithms for the single-hemisphere jet mass distribution in e+e- annihilation including the finite-Nc corrections. The result is compared with the previous all-order result in the large-Nc limit as well as fixed-order perturbative calculations.

  3. Baryon resonances in large Nc QCD

    NASA Astrophysics Data System (ADS)

    Matagne, N.; Stancu, Fl.

    2015-01-01

    The current status and open challenges of large Nc QCD baryon spectroscopy are reviewed. After introducing the 1 /Nc expansion method, the latest achievements for the ground state properties are revisited. Next the applicability of this method to excited states is presented using two different approaches with their advantages and disadvantages. Selected results for the spectrum and strong and electromagnetic decays are described. Also further developments for the applicability of the method to excited states are presented, based on the qualitative compatibility between the quark excitation picture and the meson-nucleon scattering picture. A quantitative comparison between results obtained from the mass formula of the 1 /Nc expansion method and quark models brings convincing support to quark models and the implications of different large Nc limits are discussed. The SU(6) spin-flavor structure of the large Nc baryon allows a convenient classification of highly excited resonances into SU(3) multiplets and predicts mass ranges for the missing partners.

  4. PARTICIPANT RECRUITMENT AND RETENTION FOR THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    EPA's National Exposure Research Laboratory (NERL) completed a 12 month Particulate Matter (PM) Panel Study in the Research Triangle Park, NC area in May 2001. A primary goal of the study was to compare PM levels measured at an ambient and residential sites with those from per...

  5. REAL-TIME PERSONAL NEPHELOMETER AND TIME ACTIVITY DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study was conducted in the Research Triangle Park, NC, area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-populations: a group of African-Americans living in an environm...

  6. ONGOING FUNDAMENTAL HAZARDOUS WASTE INCINERATION RESEARCH AT EPA/RTP FACILITY

    EPA Science Inventory

    The paper describes five combustors, results of some completed research, and plans for future studies at EPA/AEERL's RCRA-permitted facility at Research Triangle Park, NC. esearch is conducted to examine the effect of operating parameters such as residence time, temperature, turb...

  7. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis.

    PubMed

    Gupta, Indranil; Ganguly, Souradipta; Rozanas, Christine R; Stuehr, Dennis J; Panda, Koustubh

    2016-07-19

    Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, but also activate Rtp801, a key proinflammatory cellular factor involved in tobacco smoke-induced lung damage. Rtp801 triggers nuclear factor κB and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess superoxide produced during Rtp801 activation, contribute to increased oxido-nitrosative stress and lung protein nitration. However, lung-specific inhibition of iNOS with a iNOS-specific inhibitor, N6-(1-iminoethyl)-L-lysine, dihydrochloride (L-NIL) solely restricts lung protein nitration but fails to prevent or reverse the major tobacco smoke-induced oxidative lung injury. In comparison, the dietary antioxidant, ascorbate or vitamin C, can substantially prevent such damage by inhibiting both tobacco smoke-induced lung protein oxidation as well as activation of pulmonary Rtp801 and consequent iNOS/NO-induced nitration of lung proteins, that otherwise lead to increased proteolysis of such oxidized or nitrated proteins by endogenous lung proteases, resulting in emphysematous lung damage. Vitamin C also restricts the up-regulation of matrix-metalloproteinase-9, the major lung protease involved in the proteolysis of such modified lung proteins during tobacco smoke-induced emphysema. Overall, our findings implicate tobacco-smoke oxidant(s) as the primary etiopathogenic factor behind both the noncellular and cellular damage mechanisms governing emphysematous lung injury and demonstrate the potential of vitamin C to accomplish holistic prevention of such damage. PMID:27382160

  8. Customer response to day-ahead wholesale market electricity prices: Case study of RTP program experience in New York

    SciTech Connect

    Goldman, C.; Hopper, N.; Sezgen, O.; Moezzi, M.; Bharvirkar, R.; Neenan, B.; Boisvert, R.; Cappers, P.; Pratt, D.

    2004-07-01

    There is growing interest in policies, programs and tariffs that encourage customer loads to provide demand response (DR) to help discipline wholesale electricity markets. Proposals at the retail level range from eliminating fixed rate tariffs as the default service for some or all customer groups to reinstituting utility-sponsored load management programs with market-based inducements to curtail. Alternative rate designs include time-of-use (TOU), day-ahead real-time pricing (RTP), critical peak pricing, and even pricing usage at real-time market balancing prices. Some Independent System Operators (ISOs) have implemented their own DR programs whereby load curtailment capabilities are treated as a system resource and are paid an equivalent value. The resulting load reductions from these tariffs and programs provide a variety of benefits, including limiting the ability of suppliers to increase spot and long-term market-clearing prices above competitive levels (Neenan et al., 2002; Boren stein, 2002; Ruff, 2002). Unfortunately, there is little information in the public domain to characterize and quantify how customers actually respond to these alternative dynamic pricing schemes. A few empirical studies of large customer RTP response have shown modest results for most customers, with a few very price-responsive customers providing most of the aggregate response (Herriges et al., 1993; Schwarz et al., 2002). However, these studies examined response to voluntary, two-part RTP programs implemented by utilities in states without retail competition.1 Furthermore, the researchers had limited information on customer characteristics so they were unable to identify the drivers to price response. In the absence of a compelling characterization of why customers join RTP programs and how they respond to prices, many initiatives to modernize retail electricity rates seem to be stymied.

  9. REL3.0 LPLA Monthly NC

    Atmospheric Science Data Center

    2016-06-02

    ... Forcing Surface Skin Temperature Column Precipitable Water Total Cloud Amount Order Data:  Reverb:  Order Data ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3.0_lpla_monthly_nc ...

  10. Optimal RTP Based Power Scheduling for Residential Load in Smart Grid

    NASA Astrophysics Data System (ADS)

    Joshi, Hemant I.; Pandya, Vivek J.

    2015-12-01

    To match supply and demand, shifting of load from peak period to off-peak period is one of the effective solutions. Presently flat rate tariff is used in major part of the world. This type of tariff doesn't give incentives to the customers if they use electrical energy during off-peak period. If real time pricing (RTP) tariff is used, consumers can be encouraged to use energy during off-peak period. Due to advancement in information and communication technology, two-way communications is possible between consumers and utility. To implement this technique in smart grid, home energy controller (HEC), smart meters, home area network (HAN) and communication link between consumers and utility are required. HEC interacts automatically by running an algorithm to find optimal energy consumption schedule for each consumer. However, all the consumers are not allowed to shift their load simultaneously during off-peak period to avoid rebound peak condition. Peak to average ratio (PAR) is considered while carrying out minimization problem. Linear programming problem (LPP) method is used for minimization. The simulation results of this work show the effectiveness of the minimization method adopted. The hardware work is in progress and the program based on the method described here will be made to solve real problem.

  11. DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination.

    PubMed

    Noseda, Roberta; Belin, Sophie; Piguet, Françoise; Vaccari, Ilaria; Scarlino, Stefania; Brambilla, Paola; Martinelli Boneschi, Filippo; Feltri, Maria Laura; Wrabetz, Lawrence; Quattrini, Angelo; Feinstein, Elena; Huganir, Richard L; Bolino, Alessandra

    2013-09-18

    Signals that promote myelination must be tightly modulated to adjust myelin thickness to the axonal diameter. In the peripheral nervous system, axonal neuregulin 1 type III promotes myelination by activating erbB2/B3 receptors and the PI3K/AKT/mTOR pathway in Schwann cells. Conversely, PTEN (phosphatase and tensin homolog on chromosome 10) dephosphorylates PtdIns(3,4,5)P3 and negatively regulates the AKT pathway and myelination. Recently, the DLG1/SAP97 scaffolding protein was described to interact with PTEN to enhance PIP3 dephosphorylation. Here we now report that nerves from mice with conditional inactivation of Dlg1 in Schwann cells display only a transient increase in myelin thickness during development, suggesting that DLG1 is a transient negative regulator of myelination. Instead, we identified DDIT4/RTP801/REDD1 as a sustained negative modulator of myelination. We show that DDIT4 is expressed in Schwann cells and its maximum expression level precedes the peak of AKT activation and of DLG1 activity in peripheral nerves. Moreover, loss of DDIT4 expression both in vitro and in vivo in Ddit4-null mice provokes sustained hypermyelination and enhanced mTORC1 activation, thus suggesting that this molecule is a novel negative regulator of PNS myelination. PMID:24048858

  12. 78 FR 37963 - Safety Zone; Fifth Coast Guard District Fireworks Display Cape Fear River; Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Fifth Coast Guard District Fireworks Display Cape Fear River; Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is temporarily changing the enforcement location of a safety zone for one...

  13. 77 FR 31803 - Safety Zone for Fifth Coast Guard District Fireworks Display Currituck Sound; Corolla, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... the regulation listed at 33 CFR 165.506 last year and was published in 76 FR 31843. The Coast Guard... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone for Fifth Coast Guard District Fireworks Display Currituck Sound; Corolla, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed...

  14. 75 FR 19435 - Disaster Declaration # 12112 and # 12113 North Carolina Disaster # NC-00026

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... ADMINISTRATION Disaster Declaration 12112 and 12113 North Carolina Disaster NC-00026 AGENCY: Small Business... State of North Carolina dated 04/07/2010. Incident: Severe Storms and Tornadoes. Incident Period: 03/28... physical damage is 12112 C and for economic injury is 12113 0. The State which received an EIDL...

  15. 75 FR 32820 - North Carolina Disaster #NC-00028 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... ADMINISTRATION North Carolina Disaster NC-00028 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration...., Suite 6050, Washington, DC 20416. SUPPLEMENTARY INFORMATION: Notice is hereby given that as a result...

  16. 78 FR 15797 - Eastern Band of Cherokee Indians Disaster #NC-00049

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... ADMINISTRATION Eastern Band of Cherokee Indians Disaster NC-00049 AGENCY: U.S. Small Business Administration... Assistance Only for the Eastern Band of Cherokee Indians (FEMA-4103-DR), dated 03/01/2013. Incident: Severe... adversely affected by the disaster: Primary Areas: Eastern Band of Cherokee Indians and Associated...

  17. 75 FR 37720 - Safety Zone; New Bern Air Show, Neuse River, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; New Bern Air Show, Neuse River, NC AGENCY... New Bern Air Show. This action is intended to restrict vessel traffic movement on the Neuse River to protect mariners and property from the hazards associated with air show events. DATES: This rule...

  18. 77 FR 3326 - Cancellation of Environmental Impact Statement in Orange County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... [Federal Register Volume 77, Number 14 (Monday, January 23, 2012)] [Notices] [Page 3326] [FR Doc.... Clarence W. Coleman, Jr., Preconstruction and Environmental Team Leader, Raleigh, North Carolina. [FR Doc... Environmental Impact Statement in Orange County, NC AGENCY: Federal Highway Administration (FHWA),...

  19. HEAVY METAL AND ORGANIC-RICH MUD POLLUTANT SAMPLE SITES, NEUSE RIVER WATERSHED, NC

    EPA Science Inventory

    East Carolina University, Geology Department and the School of Medicine, with financial support from the US Environmental Protection Agency, Albemarle-Pamlico Estuarine Study of the NC Dept. of Environment, Health and Natural Resources, collected and studied bottom sediments in t...

  20. 78 FR 34579 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... (NPRM) for this rule on April 19, 2013 (78 FR 23519). We received no comments on the proposed rule. B...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  1. 77 FR 30445 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ...) 366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). 4. Public...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The...

  2. 77 FR 45488 - Safety Zone, Atlantic Intracoastal Waterway; North Topsail Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... published in 77 FR 35898. We received no comments on the proposed rule. No public meeting was requested, and... Topsail Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  3. 77 FR 47520 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information On June 13, 2012 a Notice of Proposed Rule Making (NPRM) was published in 77 FR 35321. We received no..., Wrightsville Channel; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule....

  4. 78 FR 22195 - Safety Zone; Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed....'' (77 FR 41911, USCG-2012-0368). We received no adverse comments on the proposed rule or temporary final...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  5. 77 FR 41911 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... Rule Making (NPRM) was published in the Federal Register (77 FR 30445). We received no comments on the...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  6. 77 FR 64904 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Proposed Rulemaking (NPRM) (33 FR 50444). We received no comments on the proposed rule. No public meeting... Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  7. 77 FR 35898 - Safety Zone, Atlantic Intracoastal Waterway; North Topsail Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). ] 4. Public Meeting... Topsail Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The...

  8. 77 FR 50444 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A... Federal Register (73 FR 3316). 4. Public Meeting We do not now plan to hold a public meeting. But you may... Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast...

  9. 78 FR 34881 - Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Rulemaking for this event in the Federal Register (78 FR 19155). We received no comments on the proposed rule... Channel; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The...

  10. 75 FR 20859 - Temporary Concession Contract for Blue Ridge Parkway, NC/VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... National Park Service Temporary Concession Contract for Blue Ridge Parkway, NC/VA AGENCY: National Park... Blue Ridge Parkway. SUMMARY: Pursuant to 36 CFR 51.24, public notice is hereby given that the National... services within Blue Ridge Parkway, North Carolina and Virginia for a term not to exceed 3 years....

  11. 76 FR 39771 - Special Local Regulations for Marine Events; Lake Gaston, Enterprise, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Federal Register (76 FR 30069). We received no comments on the proposed rule. No public meeting was..., Enterprise, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is..., adjacent to the Eaton Ferry Bridge in Enterprise, North Carolina on August 13, 2011. This Special...

  12. 76 FR 30069 - Special Local Regulations for Marine Events; Lake Gaston, Enterprise, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may..., Enterprise, NC AGENCY: Coast Guard, DHS. ] ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard... waters of Lake Gaston, adjacent to the Eaton Ferry Bridge in Enterprise, North Carolina. This...

  13. 75 FR 17792 - North Carolina Disaster # NC-00025 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... ADMINISTRATION North Carolina Disaster NC-00025 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration... the Administrator's EIDL declaration, applications for economic injury disaster loans may be filed...

  14. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  15. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N., longitude 78°00.1′ W., across the Cape Fear River Entrance to Oak Island Light....

  16. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  17. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N., longitude 78°00.1′ W., across the Cape Fear River Entrance to Oak Island Light....

  18. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  19. 33 CFR 80.520 - Cape Hatteras, NC to Cape Lookout, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Hatteras, NC to Cape Lookout, NC. 80.520 Section 80.520 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.520 Cape Hatteras,...

  20. Registration of NC06BGTAG12, and NC06BGTAG13 Powdery Mildew Resistant Wheat Germplasm.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Common winter wheat (Triticum aestivum L.) germplasm lines NC06BGTAG12 (Reg. no. GP-------, PI 642416), and NC06BGTAG13 (Reg. no. GP-------, PI 612417), were developed and released by the North Carolina Agricultural Research Service and the USDA-ARS in 2006. These germplasms were released because of...

  1. Method Analysis of Microbial-Resistant Gypsum Products

    EPA Science Inventory

    Method Analysis of Microbial-Resistant Gypsum ProductsD.A. Betancourt1, T.R.Dean1, A. Evans2, and G.Byfield2 1. US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory; RTP, NC 277112. RTI International, RTP, NCSeveral...

  2. AIR PARTICULATE POLLUTION EXPOSURE INDUCES SYSTEMIC OXIDATIVE STRESS IN HEALTHY MICE

    EPA Science Inventory

    Air particulate pollution exposure induces systemic oxidative stress in healthy mice

    Elizabeth S Roberts1 and Kevin L Dreher2. 1 College or Veterinary Medicine, NC State University, Raleigh, NC , 2US Environmental Protection Agency, NHEERL, RTP, NC

    Epidemiological s...

  3. Carbon Nanotubes Investigated by N@C60 and N@C70 Spin Probes

    NASA Astrophysics Data System (ADS)

    Corzilius, B.; Gembus, A.; Dinse, K.-P.; Simon, F.; Kuzmany, H.

    2005-09-01

    Nitrogen atoms encapsulated in C60 can be used to detect small deviations from spherical symmetry via deformation-induced non-vanishing Zero-Field-Splitting (ZFS). In this context, experiments were performed by using these electronic quartet spin probes to investigate single wall carbon nanotubes. Time-fluctuating ZFS interaction would be indicative for rotational and/or translational degrees of freedom. Using pulsed EPR techniques, spin relaxation rates of N@C60 and also of N@C70 molecules with inherent static ZFS were measured. The analysis of their temperature dependence gave information about the dynamics of N@C60 and N@C70 molecules confined to the inside of the tubes.

  4. HYDROLOGIC UNITS - NEUSE RIVER BASIN, NC 5-KM BUFFERED

    EPA Science Inventory

    The US Department of Agriculture-Natural Resources Conservation Service (NRCS), Raleigh Office in cooperation with the NC Center for Geographic Information & Analysis, and the NC Dept. of Environment, Health and Natural Resources, Division of Water Quality developed the Hydrologi...

  5. Strong decays of excited baryons in Large Nc QCD

    SciTech Connect

    Goity, J. L.; Scoccola, N. N.

    2007-02-12

    We present the analysis of the strong decays widths of excited baryons in the framework of the 1/Nc expansion of QCD. These studies are performed up to order 1/Nc and include both positive and negative parity excited baryons.

  6. Strong decays of excited baryons in Large Nc QCD

    SciTech Connect

    Goity, Jose; Scoccola, Norberto

    2007-02-01

    We present the analysis of the strong decays widths of excited baryons in the framework of the 1/Nc expansion of QCD. These studies are performed up to order 1/Nc and include both positive and negative parity excited baryons.

  7. The AREVA NC Cadarache Plant Dismantling Plan

    SciTech Connect

    Sainte Marie, Noel de

    2008-01-15

    The AREVA NC Cadarache Plant has manufactured MOX fuel (mixed uranium and plutonium oxides fuel assemblies) for forty years. The plant was first dedicated to fast neutrons reactors fuels. Then, it produced 345 tons of MOX fuel for light water reactors for French and European customers. 50 tons of plutonium was recycled. In July 2003 the manufacturing of commercial fuel stopped and the plant has entered a double process plan : - conditioning production scraps issued from former fabrications in order to send them to the AREVA NC La Hague Plant for treatment and recycling process, - carrying out of the dismantling operations of these facilities. In conclusion: In a social context and with a bi-activity, AREVA NC Cadarache knows how to adapt itself and answer the increasing challenge of the dismantling activity, with very satisfactory results. After the final stop of the scraps conditioning in 2008, AREVA NC Cadarache plant is going to reach its rhythm of 80 equipments dismantled per year and to end the operations on equipments in active zone in 2013. As a consequence, new challenges begin : - adapt the organisation to integrate an increasing number of outside companies while guaranteeing a high level of safety-security, - consolidate the good radiation protection results of the staff, - respect the costs and delays of the project by putting the priority on the critical path of the schedule, - absorb the increase of waste flows, while maintaining low level of waste intended for deep storage, - improve dismantling performances and implement new techniques by integrating the experience feedback and innovation development.

  8. Three-nucleon forces in the 1/Nc expansion

    NASA Astrophysics Data System (ADS)

    Phillips, Daniel R.; Schat, Carlos

    2013-09-01

    The operator structures that can contribute to three-nucleon forces are classified in the 1/Nc expansion. At leading order in 1/Nc a spin-flavor-independent term is present, as are the spin-flavor structures associated with the Fujita-Miyazawa three-nucleon force. Modern phenomenological three-nucleon forces are thus consistent with this O(Nc) leading force, corrections to which are suppressed by a power series in 1/Nc2. A complete basis of operators for the three-nucleon force, including all independent momentum structures, is given explicitly up to next-to-leading order in the 1/Nc expansion.

  9. 77 FR 37319 - Safety Zone for Fifth Coast Guard District Fireworks Display Pasquotank River; Elizabeth City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone for Fifth Coast Guard District Fireworks Display Pasquotank River; Elizabeth City, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is temporarily changing the enforcement location of a safety zone for...

  10. Psychovisual masks and intelligent streaming RTP techniques for the MPEG-4 standard

    NASA Astrophysics Data System (ADS)

    Mecocci, Alessandro; Falconi, Francesco

    2003-06-01

    like: DivX, Xvid, and Cisco"s Mpeg-4IP, have been analyzed but, as for today, they do not support VO). The original code has been deeply modified to integrate the SLIC and to adapt it for real-time streaming. A personal RTP (Real Time Protocol) has been defined and a Client-Server application has been developed. The viewer can decode and demultiplex the stream in real-time, while adapting to the changing modalities adopted by the Server according to the current video content. The proposed codec works as follows: the image background is separated by means of a segmentation module and it is transmitted by means of a wavelet compression scheme similar to that used in the JPEG2000. The VO are coded separately and multiplexed with the background stream. At the receiver the stream is demultiplexed to obtain the background and the VO that are subsequently pasted together. The final quality depends on many factors, in particular: the quantization parameters, the Group Of Video Object (GOV) length, the GOV structure (i.e. the number of I-P-B VOP), the search area for motion compensation. These factors are strongly related to the following measurement parameters (that have been defined during the development): the Objects Apparent Size (OAS) in the scene, the Video Object Incidence factor (VOI), the temporal correlation (measured through the Normalized Mean SAD, NMSAD). The SLIC module analyzes the currently transmitted video and selects the most appropriate settings by choosing from a predefined set of transmission modalities. For example, in the case of a highly temporal correlated sequence, the number of B-VOP is increased to improve the compression ratio. The strategy for the selection of the number of B-VOP turns out to be very different from those reported in the literature for B-frames (adopted for MPEG-1 and MPEG-2), due to the different behaviour of the temporal correlation when limited only to moving objects. The SLIC module also decides how to transmit the background

  11. Psychovisual masks and intelligent streaming RTP techniques for the MPEG-4 standard

    NASA Astrophysics Data System (ADS)

    Mecocci, Alessandro; Falconi, Francesco

    2003-06-01

    like: DivX, Xvid, and Cisco"s Mpeg-4IP, have been analyzed but, as for today, they do not support VO). The original code has been deeply modified to integrate the SLIC and to adapt it for real-time streaming. A personal RTP (Real Time Protocol) has been defined and a Client-Server application has been developed. The viewer can decode and demultiplex the stream in real-time, while adapting to the changing modalities adopted by the Server according to the current video content. The proposed codec works as follows: the image background is separated by means of a segmentation module and it is transmitted by means of a wavelet compression scheme similar to that used in the JPEG2000. The VO are coded separately and multiplexed with the background stream. At the receiver the stream is demultiplexed to obtain the background and the VO that are subsequently pasted together. The final quality depends on many factors, in particular: the quantization parameters, the Group Of Video Object (GOV) length, the GOV structure (i.e. the number of I-P-B VOP), the search area for motion compensation. These factors are strongly related to the following measurement parameters (that have been defined during the development): the Objects Apparent Size (OAS) in the scene, the Video Object Incidence factor (VOI), the temporal correlation (measured through the Normalized Mean SAD, NMSAD). The SLIC module analyzes the currently transmitted video and selects the most appropriate settings by choosing from a predefined set of transmission modalities. For example, in the case of a highly temporal correlated sequence, the number of B-VOP is increased to improve the compression ratio. The strategy for the selection of the number of B-VOP turns out to be very different from those reported in the literature for B-frames (adopted for MPEG-1 and MPEG-2), due to the different behaviour of the temporal correlation when limited only to moving objects. The SLIC module also decides how to transmit the background

  12. NC TEACH and NC TEACH OnLine: Viable Alternative Routes to Teaching in North Carolina

    ERIC Educational Resources Information Center

    Simmons, Sara Coble; Mebane, Dorothy J.

    2005-01-01

    Since 2000, North Carolina has offered an alternative route to licensure for adults who desire to move into teaching from other careers. NC TEACH is a statewide alternative teacher preparation program aimed at recruiting, supporting, and retaining highly skilled mid-career professionals who seek to enter the teaching profession through the lateral…

  13. Chiral Rings of Deconstructive [SU(nc)]N Quivers

    NASA Astrophysics Data System (ADS)

    Di Napoli, Edoardo; Kaplunovsky, Vadim S.; Sonnenschein, Jacob

    2004-06-01

    Dimensional deconstruction of 5D SQCD with general nc, nf and kCS gives rise to 4D N=1 gauge theories with large quivers of SU(nc) gauge factors. We construct the chiral rings of such [SU(nc)]N theories, off-shell and on-shell. Our results are broadly similar to the chiral rings of single U(nc) theories with both adjoint and fundamental matter, but there are also some noteworthy differences such as nonlocal meson-like operators where the quark and antiquark fields belong to different nodes of the quiver. And because our gauge groups are SU(nc) rather than U(nc), our chiral rings also contain a whole zoo of baryonic and antibaryonic operators.

  14. Properties Of N@C60-Derived Peapods

    NASA Astrophysics Data System (ADS)

    Gembus, A.; Simon, F.; Jánossy, A.; Kuzmany, H.; Dinse, K.-P.

    2004-09-01

    Using pulsed EPR techniques, the basic spin relaxation properties of N@C60-based peapods were determined. In contrast to narrow line spectra typical for N@C60 in solid solution or in a C60 matrix, substantial line broadening is observed for the SWCNT-encapsulated N@C60 molecules, which might be indicative for uniaxial cage distortion by interaction with the nanotube.

  15. GASEOUS CO-POLLUTANTS ASSOCIATED WITH PARTICULATE MATTER-RESULTS FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    The U.S. EPA National Exposure Research Laboratory (NERL) conducted a longitudinal particulate matter (PM) panel study in Research Triangle Park, NC between June 2000 and June 2001. Participants were selected from two potentially susceptible sub-populations: a multi-racial grou...

  16. Preparation and EPR characterization of N@C60 and N@C70 based peapods

    NASA Astrophysics Data System (ADS)

    Corzilius, B.; Gembus, A.; Weiden, N.; Dinse, K.-P.

    2005-09-01

    Using the quartet spin of encased nitrogen atoms as an electron paramagnetic resonance (EPR) probe, it is possible to examine the fullerene/nanotube interactions in a peapod. A purification method is developed which allows low temperature filling of nanotubes with endohedral fullerenes. The paramagnetic impurities of undoped single wall carbon nanotubes (SWNT) are characterized via EPR resulting in a broad superparamagnetic signal of the remaining catalyst particles and a rather narrow signal of carbonaceous material. Comparison of EPR spectra of several nitrogen endohedral doped peapods with their analogues obtained in a solid fullerene matrix shows a significant broadening of N@C60 and N@C70 EPR signals. This broadening is related to a non-vanishing zero-field splitting caused by deformation of the fullerene cage upon encapsulation.

  17. 33 CFR 117.822 - Beaufort Channel, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Beaufort Channel, NC. 117.822... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements North Carolina § 117.822 Beaufort Channel, NC. The draw of the US 70 bridge, mile 0.1, at Beaufort, shall open as follows: (a) From 6 a.m. to 10 p.m.,...

  18. 33 CFR 117.822 - Beaufort Channel, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Beaufort Channel, NC. 117.822... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements North Carolina § 117.822 Beaufort Channel, NC. The draw of the US 70 bridge, mile 0.1, at Beaufort, shall open as follows: (a) From 6 a.m. to 10 p.m.,...

  19. 76 FR 55554 - Amendment of Class E Airspace; Rutherfordton, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... E airspace 700 feet above the surface, at Rutherfordton, NC (76 FR 31510) Docket No. FAA-2010-1330...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Rutherfordton, NC...

  20. 76 FR 67056 - Amendment of Class E Airspace; Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... Airspace at Jacksonville, NC, to accommodate the new Area Navigation (RNAV) Global Positioning System (GPS... Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures developed for..., NC (76 FR 52291). Interested parties were invited to participate in this rulemaking effort...

  1. AmeriFlux US-NC2 NC_Loblolly Plantation

    SciTech Connect

    Noormets, Asko

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NC2 NC_Loblolly Plantation. Site Description - The North Carolina Loblolly Pine site is located in a pine plantation amongst the mixed forests of the North Carolina lower coastal plain. During the late 19th and early 20th centuries the region was logged extensively. After a series of clearcuts, the land was transformed for agricultural practices. In 1967 and 1969, 4000 ha was sold to the Weyerhauser company for agriculture, preservation, and commercial logging of loblolly pines in a series of plantations. The fifth rotation stand surrounding the tower was established in 1992. The only significant natural disturbances during the measurement period was a severe drought that spanned the entire duration of the 2007 growing season. Consequently, the 2007 total amount of precipitation was 486 mm below the 30-year norm. In the same year, the plantation was thinned and fertilized. The stand was thinned in Oct 2009. The eastern half of the site was fertilized in January 2011, and the entire site was fertilized in October 2012.

  2. REL3.0 SW MONTHLY LOCAL NC

    Atmospheric Science Data Center

    2016-06-02

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3_sw_monthly_nc ...

  3. 76 FR 18669 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... River high rise bridge in Carteret County, NC. This safety zone is necessary to provide for safety...

  4. INGEN: A COBRA-NC input generator user's manual

    SciTech Connect

    Wheeler, C.L.; Dodge, R.E.

    1986-12-01

    The INGEN (INput GENerator) computer program has been developed as a preprocessor to simplify input generation for the COBRA-NC computer program. INGEN uses several empirical correlations and geometric assumptions to simplify the data input requirements for the COBRA-NC computer code. The simplified input scheme is obtained at the expense of much flexibility provided by COBRA-NC. For more complex problems requiring additional flexibility however, INGEN may be used to provide a skeletal input file to which the more detailed input may be added. This report describes the input requirements for INGEN and describes the algorithms and correlations used to generate the COBRA-NC input. 9 refs., 3 figs., 6 tabs.

  5. Large Nc from Seiberg-Witten curve and localization

    NASA Astrophysics Data System (ADS)

    Russo, Jorge G.

    2015-09-01

    When N = 2 gauge theories are compactified on S4, the large Nc limit then selects a unique vacuum of the theory determined by saddle-point equations, which remains determined even in the flat-theory limit. We show that exactly the same equations can be reproduced purely from Seiberg-Witten theory, describing a vacuum where magnetically charged particles become massless, and corresponding to a specific degenerating limit of the Seiberg-Witten spectral curve where 2Nc - 2 branch points join pairwise giving aDn = 0, n = 1 , … ,Nc - 1. We consider the specific case of N = 2 SU (Nc) SQCD coupled with 2Nf massive fundamental flavors. We show that the theory exhibits a quantum phase transition where the critical point describes a particular Argyres-Douglas point of the Riemann surface.

  6. Science Professionals and the NC-PIMS Project

    NASA Astrophysics Data System (ADS)

    Haase, David G.; D'Arruda, Jose'j.

    2003-11-01

    The North Carolina Partnership for Improving Mathematics and Science (NC-PIMS) is a multi-campus and multi-school district collaboration to improve K-12 student achievement in science and mathematics and to reduce achievement gaps. This five-year, 17 county project target predominantly rural schools in southeastern NC. In NC-PIMS science, technology, engineering and mathematics (STEM) professionals serve in roles as curriculum consultants, knowledge resources, and as role models. We will discuss how the project is planned and the motivations for recruiting STEM's to support K-12 education. NC-PIMS is a collaborative program sponsored by the National Science Foundation under Award No. EHR-0226877 and the US Department of Education under Award No. S266A020001 managed by The University of North Carolina.

  7. REL3.0 SW 3HRLY NC

    Atmospheric Science Data Center

    2016-06-02

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3.0_sw_3hrly_nc ...

  8. REL3.0 SW MONTHLY UTC NC

    Atmospheric Science Data Center

    2016-06-02

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3_sw_monthly_nc ...

  9. 76 FR 49664 - Drawbridge Operation Regulation; Beaufort Channel, Beaufort, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... Triathlon''. This deviation allows the bridge to remain in the closed position during the race to ensure the..., at Beaufort, NC. The bike route of the ``Neuse Riverkeeper Foundation Sprint Triathlon'' crosses...

  10. 75 FR 30305 - Drawbridge Operation Regulation; Perquimans River, Hertford, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ..., Hertford, NC'' in the Federal Register (74 FR 10850-10853). The rulemaking would have allowed the.... Elliott, Fifth Coast Guard District; telephone (757) 398-6557, e-mail ] Sandra.s.elliott@uscg.mil . If...

  11. Synthesis, thermolysis, and sensitivities of HMX/NC energetic nanocomposites.

    PubMed

    Wang, Yi; Song, Xiaolan; Song, Dan; Liang, Li; An, Chongwei; Wang, Jingyu

    2016-07-15

    1,3,5,7-Tetranittro-1,3,5,7-tetrazocane/nitrocellulose (HMX/NC) nanocomposites were successfully synthesized by an improved sol-gel-supercritical method. NC nanoparticles with a size of ∼30nm were cross-linked to form a network structure, and HMX nanoparticles were imbedded in the nano-NC matrix. The key factors, i.e., the selection of catalyst and solvent, were probed. No phase transformation of the HMX occurred before or after fabrication, and the molecular structures of the HMX and NC did not change. Thermal analyses were performed, and the kinetic and thermodynamic parameters, such as activation energy (EK), per-exponent factor (lnAK), rate constant (k), activation heat (ΔH(≠)), activation free energy (ΔG(≠)), activation entropy (ΔS(≠)), critical temperature of thermal explosion (Tb), and critical heating rate of thermal explosion (dT/dt)Tb, were calculated. The results indicate that HMX/NC presented a much lower activation energy (165.03kJ/mol) than raw HMX (282.5kJ/mol) or raw NC (175.51kJ/mol). The chemical potential (ΔG(≠)) for the thermal decomposition of HMX/NC has a positive value, which means that the activation of the molecules would not proceed spontaneously. The significantly lower ΔH(≠) value of HMX/NC, which represents the heat needed to be absorbed by an explosive molecule to change it from its initial state to an activated state, implies that the molecules of HMX/NC are much easier to be activated than those of raw HMX. Similarly, the HMX/NC presented a much lower Tb (168.2°C) than raw HMX (283.2°C). From the results of the sensitivity tests, the impact and friction sensitivities of HMX/NC were significantly decreased compared with those of raw HMX, but the thermal sensitivity was distinctly higher. The activation of the particles under external stimulation was simulated, and the mechanism was found to be crucial. Combining the thermodynamic parameters, the mechanism as determined from the results of the sensitivity tests was

  12. precision deburring using NC and robot equipment. Final report

    SciTech Connect

    Gillespie, L.K.

    1980-05-01

    Deburring precision miniature components is often time consuming and inconsistent. Although robots are available for deburring parts, they are not precise enough for precision miniature parts. Numerical control (NC) machining can provide edge break consistencies to meet requirements such as 76.2-..mu..m maximum edge break (chamfer). Although NC machining has a number of technical limitations which prohibits its use on many geometries, it can be an effective approach to features that are particularly difficult to deburr.

  13. Radar Observations of Rip Currents (duck, Nc)

    NASA Astrophysics Data System (ADS)

    Haller, M. C.; Honegger, D. A.; Catalan, P. A.

    2012-12-01

    Rip currents are often highly transient features in space and time. Hydrodynamic observations of rip currents are likewise challenging to obtain. It is especially difficult to capture synoptic observations of the entire rip current circulation. Herein, we present unique observations of a fairly persistent rip outbreak made over the course of two weeks during a field experiment at the USACE Field Research Facility (September, 2010; Duck, NC). The observations are part of a multi-investigator, multi-university project entitled "Remote Sensing and Data-Assimilative Modeling in the Littorals" (DARLA-MURI) funded by ONR. The observations demonstrate the presence of a rip current (sometimes several) regularly imaged in marine radar image sequences over a 10-day period. The large number of events captured over a short time is fairly rare, especially for this site. The presence of the rip current is also confirmed by a cross-shore array of in situ current meters that were (fortuitously) deployed near the rip channel. The rip current strength is shown to be relatively strong (20-40 cm/s), though wave forcing was modest (Hs ~1m). The surface expression of the rip was persistent to distances of several surf zone widths offshore, in contrast to other recent observations based on drifters. Interestingly, the observed rip currents also often leave the surf zone at an oblique angle to shore normal. Our analysis herein will demonstrate the direction of the rip obliquity is governed by the alongshore wind stress with little dependence on the wave conditions. Also, radar imaging of the rip is not very sensitive to the wind conditions (for the conditions observed); rips were regularly observed unless there was a strong offshore component to the wind stress. This has lead us to the hypothesis that the radar imaging mechanism of these rips generated under light to moderate wave conditions is the small scale breaking of short wind waves on the opposing current. Finally, a new filtered

  14. 78 FR 70093 - Notice of Final Federal Agency Actions on Proposed Highway in North Carolina

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ...This notice announces action taken by the FHWA and other Federal Agencies that is final within the meaning of 23 U.S.C. 139(l)(1). This final agency action relates to a proposed highway project, Bonner Bridge Replacement Project along NC 12, from Rodanthe to Bodie Island in Dare County, North Carolina. The FHWA's Record of Decision (ROD) identifies the Bridge within the Existing NC 12 Easement......

  15. Geologic and hydrologic data collected at test holes NC-6 and NC-11, Hatillo and Isabela, northwestern Puerto Rico

    USGS Publications Warehouse

    Rodríguez-Martínez, Jesús; Hartley, John L.

    1994-01-01

    Test holes NC-6 and NC-11 were drilled in the municipalities of Hatillo and Isabela, respectively, as part of a study of the aquifers in the Northern Coastal Province of Puerto Rico. Test holes NC-6 and NC-11 were drilled to depths of 2,574 and 2,120 feet below land surface, respectively. Geologic and hydrologic data collected during drilling included continuous core, water-quality samples, water-level measurements, and estimates of aquifer yields from the water-bearing zones. Test hole NC-6 penetrated five formations ranging in age from late Oligocene to early Pliocene: the Lares Limestone, the Cibao Formation, the Los Puertos Formation, the Aymamon Limestone, and the Quebradillas Limestone. This test hole also penetrated a water-table aquifer and six artesian aquifer. Test hole NC-11 penetrated four formations ranging in age from late 01igocene to middle Miocene: the San Sebastian Formation, the Cibao Formation, the Los Puertos, and the Aymamon Limestone. A water-table aquifer and four artesian aquifers were penetrated by this well.

  16. Zirconia (NC) zircon as a potential standard

    NASA Astrophysics Data System (ADS)

    Covey, A. K.; Braun, S. A.; Gualda, G. A.; Bream, B. R.; Fisher, C.; Wooden, J. L.; Schmitz, M. D.

    2012-12-01

    As microanalysis continues to advance and become more widespread there is a greater need for abundant and suitable age standards. Megacrystic zircons from the inactive Freeman Mine near Zirconia, NC were collected from weathered mine dump piles. Zirconia zircon crystals are large (> 1 mm) relative to typical zircons (up to 100s μm) and easily obtained; attributes that make them attractive as a potential standard. We present here preliminary data and assess the suitability of Zirconia zircons as a U-Pb geochronology, Hf-isotope and trace-element standard. Grains are variably fluorescent (Callahan et al, Southeastern Geol., 2007), and we used shortwave fluorescence to separate grains with high, medium, low/no fluorescence from one another. Images were taken of the grains before mounting and post-polishing to understand the fluorescence characterization of the surface to the core. After preparing the grains, we found that the fluorescence was not homogenous and did not provide a good means of separating out grains. In order to investigate the differences in fluorescence, we collected cathodoluminescence (CL) and backscatter electron (BSE) images and energy dispersive spectroscopy (EDS) maps using a Tescan Vega 3 LMU equipped with an Oxford X-max 50 mm2 solid-state EDS detector at Vanderbilt University. This allowed division of the grains into two types: (a) grains with finely oscillatory zoned rims, which are variably crosscut by dull-CL irregular zones, sometimes showing hourglass zoning; and (b) grains with cores showing more irregular, patchy zoning with and without thin oscillatory rims. EDS maps show no major element zoning in the zircon grains, but reveal a variety of inclusions, particularly of quartz and thorite. Preliminary U-Pb ages were obtained using a Perkin Elmer Elan DRCII ICP-MS coupled with a New Wave/Mechantek 213 nm Nd:YAG laser ablation system at Vanderbilt University. A total of ~150 individual ages on oscillatory-zoned (Type a) crystals yield a

  17. NC10 Bacteria in a Marine Oxygen Minimum Zone

    NASA Astrophysics Data System (ADS)

    Padilla, C. C.; Bristow, L. A.; Benson, C. R.; Sarode, N. D.; Girguis, P. R.; Glass, J. B.; DiChristina, T. J.; Thamdrup, B.; Stewart, F. J.

    2014-12-01

    Marine oxygen minimum zones (OMZs) are key regions of nitrogen cycling and nitrogen loss as N2. The potential for methane cycling to influence OMZ nitrogen budgets remains largely unknown. The anaerobic oxidation of methane (AOM) coupled to nitrite or nitrate reduction has been shown to be a potential source of methane consumption, N loss, and oxygen production in freshwater sediments, but has not been described for marine pelagic environments. Nitrite-dependent AOM is performed by bacteria of the candidate division NC10 through an intra-aerobic pathway involving the dismutation of nitric oxide to O2 and N2. We explored the potential that NC10-like bacteria are present and active in the anoxic, nitrite-rich OMZ of the Eastern Tropical North Pacific. Community transcriptome sequencing confirmed the expression of genes with top matches to the NC10 bacterium 'Candidatus Methylomirabilis oxyfera.' NC10-like transcripts increased in relative abundance with depth into the anoxic OMZ core and included genes of aerobic methanotrophy and denitrification, as well as high numbers of transcripts matching norZ nitric oxide reductase, hypothesized to play a role in the O2-yielding dismutation reaction. Phylogenetic analysis of OMZ particulate methane monooxygenase (pmoA) and 16S rRNA gene sequences recovered by PCR revealed multiple clades of NC10 phylotypes in the OMZ. Preliminary data from OMZ enrichments revealed methane-dependent nitrite consumption, but further characterization is required to identify the pathways and organisms mediating this process. These findings expand the known environmental range of NC10 and suggest the possibility of previously uncharacterized linkages between OMZ nitrogen and methane cycles.

  18. PM CONCENTRATIONS ASSOCIATED WITH PERSONAL ACTIVITIES BASED ON REAL-TIME PERSONAL NEPHELOMETRY DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study sponsored by EPA's National Exposure Research Laboratory (NERL) was conducted in the Research Triangle Park, NC area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-...

  19. Eikonal gluon bremsstrahlung at finite Nc beyond two loops

    NASA Astrophysics Data System (ADS)

    Delenda, Yazid; Khelifa-Kerfa, Kamel

    2016-03-01

    We present a general formalism for computing the matrix-element squared for the emission of soft energy-ordered gluons beyond two loops in QCD perturbation theory at finite Nc. Our formalism is valid in the eikonal approximation. A Mathematica program has been developed for the automated calculation of all real/virtual eikonal squared amplitudes needed at a given loop order. For the purpose of illustration, we show the explicit forms of the eikonal squared amplitudes up to the fifth-loop order. In the large-Nc limit, our results coincide with those previously reported in literature.

  20. O(Nc) and USp(Nc) QCD from String Theory

    NASA Astrophysics Data System (ADS)

    Imoto, T.; Sakai, T.; Sugimoto, S.

    2009-12-01

    We propose a holographic dual of large N_c quantum chromodynamics (QCD) with the gauge groups O(N_c) and USp(N_c) and N_f flavors of massless quarks. This is constructed by adding O6-planes to an intersecting D4-D8 system in type IIA superstring theory. The holographic dual description is formulated in Witten's D4-brane background with D8-branes and O6-planes embedded in it as probes. The D4-brane background gives rise to a smooth interpolation of D8-overline{D8} pairs and an O6-overline{O6} pair. We show that the resultant brane configuration explains geometrically the flavor symmetry breaking patterns in O(N_c) and USp(N_c) QCD, which are caused by quark bilinear condensates. We next discuss that baryons can be realized as D4-overline{D4} pairs wrapped on S^4, which intersect with the O6-plane. By analyzing the tachyons on it, we reproduce the stability conditions of the baryons that are expected from the gauge theory viewpoint . The stable baryon configurations are classified systematically using K-theory. We also give a similar analysis of the flux tubes and again reproduce the results that are consistent with QCD.

  1. Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle.

    PubMed

    Pastor-Fernández, Iván; Regidor-Cerrillo, Javier; Jiménez-Ruiz, Elena; Álvarez-García, Gema; Marugán-Hernández, Virginia; Hemphill, Andrew; Ortega-Mora, Luis M

    2016-01-01

    Virulence factors from the ROP2-family have been extensively studied in Toxoplasma gondii, but in the closely related Neospora caninum only NcROP2Fam-1 has been partially characterized to date. NcROP40 is a member of this family and was found to be more abundantly expressed in virulent isolates. Both NcROP2Fam-1 and NcROP40 were evaluated as vaccine candidates and exerted a synergistic effect in terms of protection against vertical transmission in mouse models, which suggests that they may be relevant for parasite pathogenicity. NcROP40 is localized in the rhoptry bulbs of tachyzoites and bradyzoites, but in contrast to NcROP2Fam-1, the protein does not associate with the parasitophorous vacuole membrane due to the lack of arginine-rich amphipathic helix in its sequence. Similarly to NcROP2Fam-1, NcROP40 mRNA levels are highly increased during tachyzoite egress and invasion. However, NcROP40 up-regulation does not appear to be linked to the mechanisms triggering egress. In contrast to NcROP2Fam-1, phosphorylation of NcROP40 was not observed during egress. Besides, NcROP40 secretion into the host cell was not successfully detected by immunofluorescence techniques. These findings indicate that NcROP40 and NcROP2Fam-1 carry out different functions, and highlight the need to elucidate the role of NcROP40 within the lytic cycle and to explain its relative abundance in tachyzoites. PMID:26521890

  2. 78 FR 14651 - Amendment of Class E Airspace; Goldsboro, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace in the Goldsboro, NC area (77 FR... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  3. 75 FR 20320 - Amendment of Class E Airspace; Smithfield, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February... to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Smithfield, NC...

  4. 75 FR 43817 - Amendment of Class E Airspace; Smithfield, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ..., Smithfield, NC (75 FR 20320) Docket No. FAA-2010-0285. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  5. 78 FR 24071 - Safety Zone; Pasquotank River; Elizabeth City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ...) 366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal... display for the Potato Festival. This action is necessary to protect the life and property of the maritime..., the NC Potato Festival will sponsor a fireworks display from a barge anchored in the Pasquotank...

  6. 77 FR 4458 - Amendment of Class E Airspace; Rockingham, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... E airspace at Rockingham, NC, (76 FR 66867) Docket No. FAA-2011-1146. Interested parties were... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  7. 78 FR 72009 - Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Federal Register a notice of proposed rulemaking to establish Class E airspace at Star, NC (78 FR 54413... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  8. 76 FR 38018 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... bridge in Carteret County, NC. This safety zone is necessary to provide for safety of life on navigable waters during the establishment of staging for bridge maintenance. This rule will enhance the safety of... in the Federal Register (33 FR 165). We received no comments on the proposed rule. No public...

  9. 76 FR 23227 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ...--Newport River high rise bridge in Carteret County, NC. This safety zone is necessary to provide for safety..., 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public... Fixed bridge, vessel traffic may use alternate waterways to transit safely around the safety zone....

  10. 76 FR 37267 - Safety Zone, Pantego Creek; Belhaven, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...The Coast Guard is establishing a temporary safety zone on the Pantego Creek, Belhaven, NC. This action is necessary to protect the life and property of the maritime public from the hazards posed by fireworks displays. This zone is intended to restrict vessels from a portion of the Pantego Creek during the Belhaven Fourth of July...

  11. 75 FR 69864 - Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... rulemaking (NPRM) to modify the Charlotte, NC Class B airspace area (75 FR 9538). This action proposed to... that was inadvertently omitted from notice (75 FR 13049; March 18, 2010). Interested parties were.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  12. 75 FR 43814 - Amendment of Class D Airspace; Goldsboro, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... D airspace for Seymour Johnson AFB, Goldsboro, NC (75 FR 17891) Docket No. FAA-2010-0095. Interested... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  13. 75 FR 17891 - Amendment of Class D Airspace; Goldsboro, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Goldsboro, NC...

  14. Can the nucleon axial charge be O(Nc0)?

    NASA Astrophysics Data System (ADS)

    Kojo, Toru

    2013-02-01

    The nucleon self-energy and its relation to the nucleon axial charge gA are discussed at large Nc. The energy is compared for the hedgehog, conventional, and recently proposed dichotomous nucleon wavefunctions which give different values for gA. We consider their energies at both perturbative and non-perturbative levels. In perturbative estimates, we take into account the pion exchanges among quarks up to the third orders of axial charge vertices, including the many-body forces such as the Wess-Zumino terms. It turns out that the perturbative pion exchanges among valence quarks give the same leading Nc contributions for three wavefunctions, while their mass differences are O(ΛQCD). The signs of splittings flip for different orders of the axial charge vertices, so it is hard to conclude which one is the most energetically favored. For non-perturbative estimates involving the modification of quark bases, we use the chiral quark soliton model as an illustration. With the hedgehog quark wavefunctions with gA of O(Nc), we investigate whether solutions with coherent pions are energetically favored. Again it is hard to give decisive conclusions, but it is possible that adding the confining effects disfavors the solution with the coherent pions, making a pion cloud around a nucleon quantum rather than coherent. The nuclear matter at large Nc is also discussed in light of the value of gA.

  15. ncRNA orthologies in the vertebrate lineage

    PubMed Central

    Pignatelli, Miguel; Vilella, Albert J.; Muffato, Matthieu; Gordon, Leo; White, Simon; Flicek, Paul; Herrero, Javier

    2016-01-01

    Annotation of orthologous and paralogous genes is necessary for many aspects of evolutionary analysis. Methods to infer these homology relationships have traditionally focused on protein-coding genes and evolutionary models used by these methods normally assume the positions in the protein evolve independently. However, as our appreciation for the roles of non-coding RNA genes has increased, consistently annotated sets of orthologous and paralogous ncRNA genes are increasingly needed. At the same time, methods such as PHASE or RAxML have implemented substitution models that consider pairs of sites to enable proper modelling of the loops and other features of RNA secondary structure. Here, we present a comprehensive analysis pipeline for the automatic detection of orthologues and paralogues for ncRNA genes. We focus on gene families represented in Rfam and for which a specific covariance model is provided. For each family ncRNA genes found in all Ensembl species are aligned using Infernal, and several trees are built using different substitution models. In parallel, a genomic alignment that includes the ncRNA genes and their flanking sequence regions is built with PRANK. This alignment is used to create two additional phylogenetic trees using the neighbour-joining (NJ) and maximum-likelihood (ML) methods. The trees arising from both the ncRNA and genomic alignments are merged using TreeBeST, which reconciles them with the species tree in order to identify speciation and duplication events. The final tree is used to infer the orthologues and paralogues following Fitch's definition. We also determine gene gain and loss events for each family using CAFE. All data are accessible through the Ensembl Comparative Genomics (‘Compara’) API, on our FTP site and are fully integrated in the Ensembl genome browser, where they can be accessed in a user-friendly manner. Database URL: http://www.ensembl.org PMID:26980512

  16. ncRNA orthologies in the vertebrate lineage.

    PubMed

    Pignatelli, Miguel; Vilella, Albert J; Muffato, Matthieu; Gordon, Leo; White, Simon; Flicek, Paul; Herrero, Javier

    2016-01-01

    Annotation of orthologous and paralogous genes is necessary for many aspects of evolutionary analysis. Methods to infer these homology relationships have traditionally focused on protein-coding genes and evolutionary models used by these methods normally assume the positions in the protein evolve independently. However, as our appreciation for the roles of non-coding RNA genes has increased, consistently annotated sets of orthologous and paralogous ncRNA genes are increasingly needed. At the same time, methods such as PHASE or RAxML have implemented substitution models that consider pairs of sites to enable proper modelling of the loops and other features of RNA secondary structure. Here, we present a comprehensive analysis pipeline for the automatic detection of orthologues and paralogues for ncRNA genes. We focus on gene families represented in Rfam and for which a specific covariance model is provided. For each family ncRNA genes found in all Ensembl species are aligned using Infernal, and several trees are built using different substitution models. In parallel, a genomic alignment that includes the ncRNA genes and their flanking sequence regions is built with PRANK. This alignment is used to create two additional phylogenetic trees using the neighbour-joining (NJ) and maximum-likelihood (ML) methods. The trees arising from both the ncRNA and genomic alignments are merged using TreeBeST, which reconciles them with the species tree in order to identify speciation and duplication events. The final tree is used to infer the orthologues and paralogues following Fitch's definition. We also determine gene gain and loss events for each family using CAFE. All data are accessible through the Ensembl Comparative Genomics ('Compara') API, on our FTP site and are fully integrated in the Ensembl genome browser, where they can be accessed in a user-friendly manner. Database URL: http://www.ensembl.org. PMID:26980512

  17. Reducing False Alarms of Annual Forecast in the Central China North-South Seismic Belt by Reverse Tracing of Precursors (RTP) Using the Pattern Informatics (PI) `Hotspots'

    NASA Astrophysics Data System (ADS)

    Zhang, Shengfeng; Wu, Zhongliang; Jiang, Changsheng

    2016-05-01

    The annual consultation on the likelihood of earthquakes in the next year, the `Annual Consultation Meeting', has been one of the most important forward forecast experiments organized by the China Earthquake Administration (CEA) since the 1970s, in which annual alarm regions are identified by an expert panel considering multi-disciplinary `anomalies'. In such annual forecasts, one of the problems in need of further technical solution is its false alarms. To tackle this problem, the concept of `reverse tracing of precursors (RTP)' is used to the annual consultation, as a temporal continuation and spatial extension of the work of Zuc(hao) et al. (Pure Appl Geophys 167:783-800, 2010). The central China north-south seismic belt (in connection to the CSEP testing region) is selected as the testing region of such an approach. Applying the concept of RTP, for an annual alarm region delineated by the Annual Consultation Meeting, the distribution of `hotspots' of the pattern informatics (PI), which targets the 5-year-scale seismic hazard, is considered. The `hit', or successful forecast, of the annual seismic hazard is shown to be related to the sufficient coverage of the `hotspots' within the annual alarm region. The ratio of the areas of the `hotspots' over the whole area of the annual alarm region is thus used to identify the false alarms which have few `hotspots'. The results of the years 2004-2012 show that using a threshold of 17 % can reduce 34 % (13 among 38) of the false alarms without losing the successful hit (being 6 in that period).

  18. Mechanism of Nucleic Acid Chaperone Function of Retroviral Nuceleocapsid (NC) Proteins

    NASA Astrophysics Data System (ADS)

    Rouzina, Ioulia; Vo, My-Nuong; Stewart, Kristen; Musier-Forsyth, Karin; Cruceanu, Margareta; Williams, Mark

    2006-03-01

    Recent studies have highlighted two main activities of HIV-1 NC protein contributing to its function as a universal nucleic acid chaperone. Firstly, it is the ability of NC to weakly destabilize all nucleic acid,(NA), secondary structures, thus resolving the kinetic traps for NA refolding, while leaving the annealed state stable. Secondly, it is the ability of NC to aggregate NA, facilitating the nucleation step of bi-molecular annealing by increasing the local NA concentration. In this work we use single molecule DNA stretching and gel-based annealing assays to characterize these two chaperone activities of NC by using various HIV-1 NC mutants and several other retroviral NC proteins. Our results suggest that two NC functions are associated with its zinc fingers and cationic residues, respectively. NC proteins from other retroviruses have similar activities, although expressed to a different degree. Thus, NA aggregating ability improves, and NA duplex destabilizing activity decreases in the sequence: MLV NC, HIV NC, RSV NC. In contrast, HTLV NC protein works very differently from other NC proteins, and similarly to typical single stranded NA binding proteins. These features of retroviral NCs co-evolved with the structure of their genomes.

  19. Micro-focused Small Angle Neutron Scattering and Imaging for Science and Engineering Using RTP--A Preliminary Study

    SciTech Connect

    Mohamed, Abdul Aziz; Al Rashid Megat Ahmad, Megat Harun; Md Idris, Faridah; Azman, Azraf; Jamro, Rafhayudi; Ibrahim, Mohd Rizal Mamat; Rahman, Anwar Abdul

    2010-01-05

    Malaysian Nuclear Agency's (Nuclear Malaysia) Small Angle Neutron Scattering (SANS) facility--(MYSANS)--is utilizing low flux of thermal neutron at the agency's 1 MW TRIGA reactor. As the design nature of the 8 m SANS facility can allow object resolution in the range between 5 and 80 nm to be obtained. It can be used to study alloys, ceramics and polymers in certain area of problems that relate to samples containing strong scatterers or contrast. The current SANS system at Malaysian Nuclear Agency is only capable to measure Q in limited range with a PSD (128x128) fixed at 4 m from the sample. The existing reactor hall that incorporate this MYSANS facility has a layout that prohibits the rebuilding of MYSANS therefore the position between the wavelength selector (HOPG) and sample and the PSD cannot be increased for wider Q range. The flux of the neutron at current sample holder is very low which around 10{sup 3} n/cm{sup 2}/sec. Thus it is important to rebuild the MYSANS to maximize the utilization of neutron. Over the years, the facility has undergone maintenance and some changes have been made. Modification on secondary shutter and control has been carried out to improve the safety level of the instrument. A compact micro-focus SANS method can suit this objective together with an improve cryostat system. This paper will explain some design concept and approaches in achieving higher flux and the modification needs to establish the micro-focused SANS.

  20. 75 FR 44916 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... of the Cape Fear River Memorial Bridge, across the Cape Fear River, mile 26.8, at Wilmington, NC. The... Cape Fear River Memorial Bridge across the Cape Fear River, mile 26.8, at Wilmington, NC has...

  1. 76 FR 53342 - Drawbridge Operation Regulations; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Cape Fear River, Wilmington, NC... operation of the Cape Fear Memorial Bridge, at mile 26.8, over Cape Fear River, at Wilmington, NC. The... structure. The Cape Fear Memorial Bridge, at mile 26.8, at Wilmington NC has vertical clearances in the...

  2. 76 FR 11960 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... of the Cape Fear River Memorial Bridge, across the Cape Fear River, mile 26.8, at Wilmington, NC. The... Fear River Memorial Bridge across the Cape Fear River, mile 26.8, at Wilmington, NC has...

  3. Steam turbine generators -from NC manufacturing to CAD/CAM

    SciTech Connect

    Searle, D.R.; King, F.E.; Kiniskern, J.M.

    1985-04-01

    A program has been designed to integrate engineering, manufacturing, and business systems using a common data base. There has been a significant increase in benefits obtained by extending the automation of the design/drafting function to include manufacturing operations. This extension would have been difficult without the existence of highly developed family-of-parts NC programs. The integration concept has also been applied to turbine buckets and is being extended to other turning-generator components.

  4. 76 FR 29645 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ...The Coast Guard is establishing a safety zone on the waters of the Newport River under the main span US 70/Morehead City--Newport River high rise bridge in Carteret County, NC. This safety zone is necessary to provide for safety of life on navigable waters during the establishment of staging for bridge maintenance. This rule will enhance the safety of the contractors performing maintenance as......

  5. TRAC-PF1 post-test predictions for the Semiscale Natural-Circulation Tests S-NC-2 and S-NC-6. [PWR

    SciTech Connect

    Booker, C.P.

    1983-01-01

    The TRAC prediction are compared to the data for the Semiscale natural-circular Tests S-NC-2B and S-NC-6. S-NC-2B is a baseline test covering single- and two-phase natural circulation as well as reflux; here TRAC compares quite well with the experiment results for mass flow. For Test S-NC-6, which is a reflux test with various amounts of nitrogen injected into the system, the TRAC prediction of the reflux rate is close to the experiment value with no nitrogen in the system. Ultimately, the maximum reflux rate predicted by TRAC is about 20% higher than the data.

  6. PERSONAL PARTICULATE MATTER EXPOSURE MONITORING: IDENTIFYING IMPORTANT SOURCES, ACTIVITIES, AND LOCATIONS BASED ON DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study was conducted in the Research Triangle Park, NC area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-populations: a group of African-Americans living in an environme...

  7. Results and lessons of the 10 years experiment of large earthquake prediction made in advance with a lead time months using Reverse Tracing of Precursors (RTP) (Invited)

    NASA Astrophysics Data System (ADS)

    Shebalin, P.

    2013-12-01

    The experiment in prospective documented earthquake prediction using the algorithm Reverse Tracing of Precursors (RTP) has been started in June 2003. The algorithm is based on the analysis of a set of intermediate-term precursors in an area of a short term long-range activation of seismicity, detected by earthquake chains. Earthquake chains are clusters of moderate-size earthquakes which extend over large distances and are formed by statistically rare pairs of events that are close in space and time. We put predictions on record at http://www.rtptest.org (with a restricted access to current predictions). Predictions are not deterministic: they are expected to be true with some probability exceeding 50%. During the period June 2003 to August 2013, 30 predictions were put on record, five of them were extended in modified area to longer intervals than standard 9 months. Those prolongations are not considered as separate predictions because they largely intersect in time and space with corresponding initial ones. Six earthquakes out of ten have been predicted (Hokkaido earthquake, September, 25, 2003, Mw=8.3; San-Simeon earthquake in California, 25 December, 2003, M=6.5, earthquake in the sea near Sendai, Japan, August 16, 2005, Mw=7.2; Simushir earthquake, Kuril Islands, November 15, 2006, Mw=8.3, Andreanoff Islands earthquake, December 19, 2007, M=7.2; Tohoku earthquake, March 11, 2011, M=9.1, Kurile Islands earthquake, April 19, 2013, M=7.2 and Okhotsk sea earthquake, May 24, 2013, M=8.3). Four earthquakes, in 2009 to 2012, have been missed. One of them is the Aquila earthquake in Central Italy, April 6th, 2009, M=6.3. We might suppose that this miss was due to an evident increase of the magnitude cut-off in the PDE catalogue we use for RTP in Italy. We have tried to complement retrospectively the catalogue with data from CSEM. However, the alarm prior to the Aquila earthquake still was not diagnosed. For three other earthquakes the situation is different. We

  8. Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP)

    PubMed Central

    Cang, Yong; Prelich, Gregory

    2002-01-01

    Negative cofactor 2 (NC2) is an evolutionarily conserved transcriptional regulator that was originally identified as an inhibitor of basal transcription. Its inhibitory mechanism has been extensively characterized; NC2 binds to the TATA-binding protein (TBP), blocking the recruitment of TFIIA and TFIIB, and thereby inhibiting preinitiation complex assembly. NC2 is also required for expression of many yeast genes in vivo and stimulates TATA-less transcription in a Drosophila in vitro transcription system, but the mechanism responsible for the NC2-mediated stimulation of transcription is not understood. Here we establish that yeast NC2 can directly stimulate activated transcription from TATA-driven promoters both in vivo and in vitro, and moreover that this positive role requires the same surface of TBP that mediates the NC2 repression activity. On the basis of these results, we propose a model to explain how NC2 can mediate both repression and activation through the same surface of TBP. PMID:12237409

  9. Classification of ncRNAs using position and size information in deep sequencing data

    PubMed Central

    Erhard, Florian; Zimmer, Ralf

    2010-01-01

    Motivation: Small non-coding RNAs (ncRNAs) play important roles in various cellular functions in all clades of life. With next-generation sequencing techniques, it has become possible to study ncRNAs in a high-throughput manner and by using specialized algorithms ncRNA classes such as miRNAs can be detected in deep sequencing data. Typically, such methods are targeted to a certain class of ncRNA. Many methods rely on RNA secondary structure prediction, which is not always accurate and not all ncRNA classes are characterized by a common secondary structure. Unbiased classification methods for ncRNAs could be important to improve accuracy and to detect new ncRNA classes in sequencing data. Results: Here, we present a scoring system called ALPS (alignment of pattern matrices score) that only uses primary information from a deep sequencing experiment, i.e. the relative positions and lengths of reads, to classify ncRNAs. ALPS makes no further assumptions, e.g. about common structural properties in the ncRNA class and is nevertheless able to identify ncRNA classes with high accuracy. Since ALPS is not designed to recognize a certain class of ncRNA, it can be used to detect novel ncRNA classes, as long as these unknown ncRNAs have a characteristic pattern of deep sequencing read lengths and positions. We evaluate our scoring system on publicly available deep sequencing data and show that it is able to classify known ncRNAs with high sensitivity and specificity. Availability: Calculated pattern matrices of the datasets hESC and EB are available at the project web site http://www.bio.ifi.lmu.de/ALPS. An implementation of the described method is available upon request from the authors. Contact: florian.erhard@bio.ifi.lmu.de PMID:20823303

  10. ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system.

    PubMed

    Wu, Deng; Huang, Yan; Kang, Juanjuan; Li, Kongning; Bi, Xiaoman; Zhang, Ting; Jin, Nana; Hu, Yongfei; Tan, Puwen; Zhang, Lu; Yi, Ying; Shen, Wenjun; Huang, Jian; Li, Xiaobo; Li, Xia; Xu, Jianzhen; Wang, Dong

    2015-01-01

    Programmed cell death (PCD) is a critical biological process involved in many important processes, and defects in PCD have been linked with numerous human diseases. In recent years, the protein architecture in different PCD subroutines has been explored, but our understanding of the global network organization of the noncoding RNA (ncRNA)-mediated cell death system is limited and ambiguous. Hence, we developed the comprehensive bioinformatics resource (ncRDeathDB, www.rna-society.org/ncrdeathdb ) to archive ncRNA-associated cell death interactions. The current version of ncRDeathDB documents a total of more than 4600 ncRNA-mediated PCD entries in 12 species. ncRDeathDB provides a user-friendly interface to query, browse and manipulate these ncRNA-associated cell death interactions. Furthermore, this resource will help to visualize and navigate current knowledge of the noncoding RNA component of cell death and autophagy, to uncover the generic organizing principles of ncRNA-associated cell death systems, and to generate valuable biological hypotheses. PMID:26431463

  11. High-speed tapping for N/C machining centers

    SciTech Connect

    Friend, J.P.

    1991-11-01

    Through a series of experiments, a new high-speed tapping technique was developed for N/C machining centers. The new technique produces high quality threads in a fraction of the time previously required, using the same equipment. Threads are produced to precise size and depth in a single pass at speeds up to 5000 rpm. Thread sizes ranged from 0.80 UNM (Unified Miniature Thread Series) (0.0315 in. major diameter) to 0.250-20 UN (Unified Screw Threads) in both blind and through-hole applications. The materials tapped included 17-4 PH stainless steel, 300 series stainless steel, and 6061-T6 aluminum. 10 figs.

  12. Contaminant-mobilizing capability of fullerene nanoparticles (nC60): Effect of solvent-exchange process in nC60 formation.

    PubMed

    Wang, Lilin; Fortner, John D; Hou, Lei; Zhang, Chengdong; Kan, Amy T; Tomson, Mason B; Chen, Wei

    2013-02-01

    Fullerene nanoparticles (nC(60)) in aqueous environments can significantly enhance the transport of hydrophobic organic contaminants by serving as a contaminant carrier. In the present study, the authors examine the effect of the solvent-exchange process on nC(60) aggregate formation and, subsequently, on nC(60) 's contaminant-mobilizing capability. A series of nC(60) samples were prepared using a modified toluene-water solvent-exchange method through the inclusion of a secondary organic solvent in the phase transfer of molecular C(60) in toluene to nC(60) in water. Two groups of solvents--a water-miscible group and a non-water-miscible group-of varied polarity were selected as secondary solvents. The involvement of a secondary solvent in the phase transfer process had only small effects on the particle size and distribution, ζ potential, and mobility of the nC(60) products but significantly influenced the capability of nC(60) to enhance the transport of 2,2',5,5'-polychlorinated biphenyl (PCB) in a saturated sandy soil column, regardless of whether the secondary solvent was water-miscible or non-water-miscible. The two groups of secondary solvents appear to affect the aggregation properties of nC(60) in water via different mechanisms. In general, nC(60) products made with a secondary water-miscible solvent have stronger capabilities to enhance PCB transport. Taken together, the results indicate that according to formation conditions and solvent constituents, nC(60) will vary significantly in its interactions with organic contaminants, specifically as related to adsorption or desorption as well as transport in porous media. PMID:23172734

  13. Niobium nitride films formed by rapid thermal processing (RTP): a study of depth profiles and interface reactions by complementary analytical techniques.

    PubMed

    Berendes, A; Brunkahl, O; Angelkort, C; Bock, W; Hofer, F; Warbichler, P; Kolbesen, B O

    2004-06-01

    The nitridation of niobium films approximately 250 and 650 nm thick by rapid thermal processing (RTP) at 800 degrees C in molecular nitrogen or ammonia was investigated. The niobium films were deposited by electron beam evaporation on silicon substrates covered by a 100 or 300 nm thick thermally grown SiO(2) layer. In these investigations the reactivity of ammonia and molecular nitrogen was compared with regard to nitride formation and reaction with the SiO(2) substrate layer. The phases formed were characterized by X-ray diffraction (XRD). Depth profiles of the elements in the films were recorded by use of secondary neutral mass spectrometry (SNMS). Microstructure and spatial distribution of the elements were imaged by transmission electron microscopy (TEM) and energy-filtered TEM (EFTEM). Electron energy loss spectra (EELS) were taken at selected positions to discriminate between different nitride, oxynitride, and oxide phases. The results provide clear evidence of the expected higher reactivity of ammonia in nitride formation and reaction with the SiO(2) substrate layer. Outdiffusion of oxygen into the niobium film and indiffusion of nitrogen from the surface of the film result in the formation of oxynitride in a zone adjacent to the Nb/SiO(2) interface. SNMS profiles of nitrogen reveal a distinct tail which is attributed to enhanced diffusion of nitrogen along grain boundaries. PMID:15098081

  14. ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATE

    EPA Science Inventory

    ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATE

    Cynthia Wolf1,2 , Joe Ostby1, Jonathan Furr 1, Gerald A. LeBlanc2, and L. Earl Gray, Jr.1
    1 US Environmental Protection Agency, NHEERL, RTD, RTP, NC 27711, 2 Departmen...

  15. THE EFFECT OF SUBMAXIMAL INHALATION ON MEASURES DERIVED FROM FORCED EXPIRATORY SPIROMETRY

    EPA Science Inventory

    THE EFFECT OF SUBMAXIMAL INHALATION ON MEASURES DERIVED FROM FORCED EXPIRATORY SPIROMETRY. William F. McDonnell Human Studies Division, NHEERL, U.S. Environmental Protection Agency, RTP, NC 27711.
    Short-term exposure to ozone results in a neurally-mediated decrease in the ab...

  16. RNA PROFILES IN RAT AND MOUSE EPIDIDYMAL SPERMATOZOA

    EPA Science Inventory

    RNA PROFILES IN RAT AND MOUSE EPIDIDYMAL SPERMATOZOA
    Kary E. Thompson1, Hongzu Ren1, Judith E. Schmid1 and David J. Dix1
    1Reproductive Toxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, RTP, NC.

    Mature spermatozoa are transcriptionally inactive...

  17. INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV)-INDUCED INFLAMMATION BY 3-NITROTYROSINE IN HUMAN BRONCHIAL EPITHELIAL CELLS

    EPA Science Inventory

    Inhibition of Respiratory Syncytial Virus (RSV)-Induced Inflammation by 3-Nitrotyrosine in Human Bronchial Epithelial Cells. J. M. Soukup, MPH 1, ZW. Li, MD 2 and YC. T. Huang, MD 1. 1 NHEERL, US Environmental Protection Agency, RTP, NC and 2 CEMALB, University of North Carolina,...

  18. Study of an NC system of machining crown gears

    NASA Astrophysics Data System (ADS)

    Xu, Xiaogang; Wang, Huaqing; Yan, Jian; Gao, Shenyou

    2005-12-01

    Crown gear couplings are usually used in metallurgy and steel rolling equipments, which is manufactured by duplicating processing in common. The method makes the manipulator work hard, and the efficiency is low. The machining precision is limited to the shape of the mold and it is difficult to control the movement of machines table. This work stated an NC system to use hobbing machine. It consists of an industrial control computer, grating sensor, servo- motor and its driver source, servo driver card and other I/O equipments of inputting and outputting. The grating sensor was installed in the axial direction to trace the instantaneous position of gob rest. The radial movement of the machine table was controlled by a servomotor. When the computer captures the axial signal, this system controls the machine table by moving ahead or backwards according to the calculated value of interpolation theory. Thus, two dimensions (axial and radial) associated movement was realized while the crown gear was processed. The feature of the system is that a grating sensor used in the axial direction replaces the servomotor. By making a little change in the mechanism of the machine, NC can be implement and its redesign cost is very low. The design software has an interpolation function for a circular arc and line. The system has been used on a Y1380 gear hobbing machine, and the correlative software of machining crown gear has been designed as well. Satisfactory results have been obtained, showing facility and reliability in practical operation.

  19. The Nc dependencies of baryon masses: Analysis with Lattice QCD and Effective Theory

    SciTech Connect

    Calle Cordon, Alvaro C.; DeGrand, Thomas A.; Goity, Jose L.

    2014-07-01

    Baryon masses at varying values of Nc and light quark masses are studied with Lattice QCD and the results are analyzed in a low energy effective theory based on a combined framework of the 1/Nc and Heavy Baryon Chiral Perturbation Theory expansions. Lattice QCD results for Nc=3, 5 and 7 obtained in quenched calculations, as well as results for unquenched calculations for Nc=3, are used for the analysis. The results are consistent with a previous analysis of Nc=3 LQCD results, and in addition permit the determination of sub-leading in 1/Nc effects in the spin-flavor singlet component of the baryon masses as well as in the hyperfine splittings.

  20. Characterizing ncRNAs in Human Pathogenic Protists Using High-Throughput Sequencing Technology

    PubMed Central

    Collins, Lesley Joan

    2011-01-01

    ncRNAs are key genes in many human diseases including cancer and viral infection, as well as providing critical functions in pathogenic organisms such as fungi, bacteria, viruses, and protists. Until now the identification and characterization of ncRNAs associated with disease has been slow or inaccurate requiring many years of testing to understand complicated RNA and protein gene relationships. High-throughput sequencing now offers the opportunity to characterize miRNAs, siRNAs, small nucleolar RNAs (snoRNAs), and long ncRNAs on a genomic scale, making it faster and easier to clarify how these ncRNAs contribute to the disease state. However, this technology is still relatively new, and ncRNA discovery is not an application of high priority for streamlined bioinformatics. Here we summarize background concepts and practical approaches for ncRNA analysis using high-throughput sequencing, and how it relates to understanding human disease. As a case study, we focus on the parasitic protists Giardia lamblia and Trichomonas vaginalis, where large evolutionary distance has meant difficulties in comparing ncRNAs with those from model eukaryotes. A combination of biological, computational, and sequencing approaches has enabled easier classification of ncRNA classes such as snoRNAs, but has also aided the identification of novel classes. It is hoped that a higher level of understanding of ncRNA expression and interaction may aid in the development of less harsh treatment for protist-based diseases. PMID:22303390

  1. ncISO Facilitating Metadata and Scientific Data Discovery

    NASA Astrophysics Data System (ADS)

    Neufeld, D.; Habermann, T.

    2011-12-01

    Increasing the usability and availability climate and oceanographic datasets for environmental research requires improved metadata and tools to rapidly locate and access relevant information for an area of interest. Because of the distributed nature of most environmental geospatial data, a common approach is to use catalog services that support queries on metadata harvested from remote map and data services. A key component to effectively using these catalog services is the availability of high quality metadata associated with the underlying data sets. In this presentation, we examine the use of ncISO, and Geoportal as open source tools that can be used to document and facilitate access to ocean and climate data available from Thematic Realtime Environmental Distributed Data Services (THREDDS) data services. Many atmospheric and oceanographic spatial data sets are stored in the Network Common Data Format (netCDF) and served through the Unidata THREDDS Data Server (TDS). NetCDF and THREDDS are becoming increasingly accepted in both the scientific and geographic research communities as demonstrated by the recent adoption of netCDF as an Open Geospatial Consortium (OGC) standard. One important source for ocean and atmospheric based data sets is NOAA's Unified Access Framework (UAF) which serves over 3000 gridded data sets from across NOAA and NOAA-affiliated partners. Due to the large number of datasets, browsing the data holdings to locate data is impractical. Working with Unidata, we have created a new service for the TDS called "ncISO", which allows automatic generation of ISO 19115-2 metadata from attributes and variables in TDS datasets. The ncISO metadata records can be harvested by catalog services such as ESSI-labs GI-Cat catalog service, and ESRI's Geoportal which supports query through a number of services, including OpenSearch and Catalog Services for the Web (CSW). ESRI's Geoportal Server provides a number of user friendly search capabilities for end users

  2. Study finds Chapel Hill, NC, soup kitchen serves nutritious meals.

    PubMed

    Eppich, Simone; Fernandez, Claudia Plaisted

    2004-08-01

    Soup kitchens attempt to improve the food security of low-income individuals, but the results of their efforts are rarely researched. We focused our study on the Inter-Faith Council Soup Kitchen (IFC) near the University of North Carolina-Chapel Hill (UNC) in Chapel Hill, NC. The IFC uses no centralized nutrition planning and relies heavily on volunteer cooks, yet we found their meals to be highly nutrient-dense when averaged over a 1-month time frame and compared with the Dietary Reference Intakes (DRIs) and the Daily Reference Values (DRVs). In fact, the only nutrients needing improvement were vitamin D, folate, and calcium. The number of servings per meal was also substantially more than one third of the US Department of Agriculture Food Guide Pyramid recommendations, except for dairy at all meals, vegetables at breakfast, and fruit at dinner. PMID:15281049

  3. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost... Buoy “2CF”); thence to Oak Island Light. (b) A line drawn from the southernmost extremity of...

  4. 77 FR 32394 - Drawbridge Operation Regulation; The Straights, Harkers Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; The Straights, Harkers Island, NC... operation of the Route 70/Harkers Island Bridge across The Straights, at Harkers Island, NC. The deviation...) owns and operates the swing span of the Route 70/Harkers Island Bridge across The Straights, in...

  5. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost... Buoy “2CF”); thence to Oak Island Light. (b) A line drawn from the southernmost extremity of...

  6. 78 FR 42011 - Drawbridge Operation Regulation; The Straights, Harkers Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; The Straights, Harkers Island, NC... 70/Harkers Island Bridge, across The Straights, mile 0.6, Harkers Island, NC. This deviation is necessary to facilitate coupling repair on the Route 70/ Harkers Island Bridge. This temporary...

  7. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost... Buoy “2CF”); thence to Oak Island Light. (b) A line drawn from the southernmost extremity of...

  8. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost... Buoy “2CF”); thence to Oak Island Light. (b) A line drawn from the southernmost extremity of...

  9. 77 FR 51699 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... operation of the Cape Fear River Memorial Bridge, at mile 26.8, over Cape Fear River, at Wilmington, NC. The... a.m. on the first or second Sunday of November every year. The Cape Fear River Memorial Bridge,...

  10. 78 FR 9587 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... Cape Fear River Memorial Bridge, across the Cape Fear River, mile 26.8, at Wilmington, NC. The... second Sunday of November every year. The Cape Fear River Memorial Bridge, at mile 26.8, at...

  11. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  12. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  13. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  14. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  15. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  16. Baryon Regge Trajectories in the Light of the 1/Nc Expansion

    SciTech Connect

    Jose L. Goity; Nicolas Matagne

    2007-11-01

    We analyze Regge trajectories in term the $1/N_c$ expansion of QCD. Neglecting spin-orbit contributions to the large $N_c$ baryon mass operator, we consider the evolution of the spin-flavor singlet component of the masses with respect $\\ell$. We find two distinct and remarkably linear Regge trajectories for symmetric and for mixed symmetric spin-flavor multiplets.

  17. 33 CFR 165.T05-0091 - Safety Zone; Alligator River, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Alligator River, NC... Safety Zone; Alligator River, NC. (a) Definitions. For the purposes of this section, Captain of the Port... on the waters of the Alligator River centered at (35°54′3″ N/076°00′25″ W) a position directly...

  18. Computational Approaches for the Analysis of ncRNA through Deep Sequencing Techniques

    PubMed Central

    Veneziano, Dario; Nigita, Giovanni; Ferro, Alfredo

    2015-01-01

    The majority of the human transcriptome is defined as non-coding RNA (ncRNA), since only a small fraction of human DNA encodes for proteins, as reported by the ENCODE project. Several distinct classes of ncRNAs, such as transfer RNA, microRNA, and long non-coding RNA, have been classified, each with its own three-dimensional folding and specific function. As ncRNAs are highly abundant in living organisms and have been discovered to play important roles in many biological processes, there has been an ever increasing need to investigate the entire ncRNAome in further unbiased detail. Recently, the advent of next-generation sequencing (NGS) technologies has substantially increased the throughput of transcriptome studies, allowing an unprecedented investigation of ncRNAs, as regulatory pathways and novel functions involving ncRNAs are now also emerging. The huge amount of transcript data produced by NGS has progressively required the development and implementation of suitable bioinformatics workflows, complemented by knowledge-based approaches, to identify, classify, and evaluate the expression of hundreds of ncRNAs in normal and pathological conditions, such as cancer. In this mini-review, we present and discuss current bioinformatics advances in the development of such computational approaches to analyze and classify the ncRNA component of human transcriptome sequence data obtained from NGS technologies. PMID:26090362

  19. Nucleic Acid Chaperone Activity of HIV-1 NC Proteins Investigated by Single Molecule DNA Stretching

    NASA Astrophysics Data System (ADS)

    Williams, Mark C.; Gorelick, Robert J.; Musier-Forsyth, Karin; Bloomfield, Victor A.

    2002-03-01

    HIV-1 Nucleocapsid Protein (NC) is a nucleic acid chaperone protein that is responsible for facilitating numerous nucleic acid rearrangements throughout the reverse transcription cycle of HIV-1. To understand the mechanism of NC’s chaperone function, we carried out single molecule DNA stretching studies in the presence of NC and mutant forms of NC. Using an optical tweezers instrument, we stretch single DNA molecules from the double-stranded helical state to the single-stranded (coil) state. Based on the observed cooperativity of DNA force-induced melting, we find that the fraction of melted base pairs at room temperature is increased dramatically in the presence of NC. Thus, upon NC binding, increased thermal fluctuations cause continuous melting and reannealing of base pairs so that DNA strands are able to rapidly sample configurations in order to find the lowest energy state. While NC destabilizes the double-stranded form of DNA, a mutant form of NC that lacks the zinc finger structures does not. DNA stretching experiments carried out in the presence of NC variants containing more subtle changes in the zinc finger structures were conducted to elucidate the contribution of each individual finger to NC’s chaperone activity, and these results will be reported.

  20. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  1. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  2. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a) Explosives Anchorage. Beginning at a point southeast...

  3. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  4. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  5. Computational Approaches for the Analysis of ncRNA through Deep Sequencing Techniques.

    PubMed

    Veneziano, Dario; Nigita, Giovanni; Ferro, Alfredo

    2015-01-01

    The majority of the human transcriptome is defined as non-coding RNA (ncRNA), since only a small fraction of human DNA encodes for proteins, as reported by the ENCODE project. Several distinct classes of ncRNAs, such as transfer RNA, microRNA, and long non-coding RNA, have been classified, each with its own three-dimensional folding and specific function. As ncRNAs are highly abundant in living organisms and have been discovered to play important roles in many biological processes, there has been an ever increasing need to investigate the entire ncRNAome in further unbiased detail. Recently, the advent of next-generation sequencing (NGS) technologies has substantially increased the throughput of transcriptome studies, allowing an unprecedented investigation of ncRNAs, as regulatory pathways and novel functions involving ncRNAs are now also emerging. The huge amount of transcript data produced by NGS has progressively required the development and implementation of suitable bioinformatics workflows, complemented by knowledge-based approaches, to identify, classify, and evaluate the expression of hundreds of ncRNAs in normal and pathological conditions, such as cancer. In this mini-review, we present and discuss current bioinformatics advances in the development of such computational approaches to analyze and classify the ncRNA component of human transcriptome sequence data obtained from NGS technologies. PMID:26090362

  6. Anion-Dependent Aggregate Formation and Charge Behavior of Colloidal Fullerenes (n-C60)

    EPA Science Inventory

    The fate and transport of colloidal fullerenes (n-C60) in the environment is likely to be guided by electrokinetic and aggregation behavior. In natural water bodies inorganic ions exert significant effects in determining the size and charge of n-C60 nanoparticles. Although the ef...

  7. 78 FR 41691 - Safety Zone; Pamlico River and Tar River; Washington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ...) 366-9826. SUPPLEMENTARY INFORMATION: ] Table of Acronyms DHS Department of Homeland Security FR... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Pamlico River and Tar River; Washington, NC... zone on the navigable waters of the Pamlico and Tar Rivers in Washington, NC in support of a...

  8. Bioinformatics of Cancer ncRNA in High Throughput Sequencing: Present State and Challenges

    PubMed Central

    Jorge, Natasha Andressa Nogueira; Ferreira, Carlos Gil; Passetti, Fabio

    2012-01-01

    The numerous genome sequencing projects produced unprecedented amount of data providing significant information to the discovery of novel non-coding RNA (ncRNA). Several ncRNAs have been described to control gene expression and display important role during cell differentiation and homeostasis. In the last decade, high throughput methods in conjunction with approaches in bioinformatics have been used to identify, classify, and evaluate the expression of hundreds of ncRNA in normal and pathological states, such as cancer. Patient outcomes have been already associated with differential expression of ncRNAs in normal and tumoral tissues, providing new insights in the development of innovative therapeutic strategies in oncology. In this review, we present and discuss bioinformatics advances in the development of computational approaches to analyze and discover ncRNA data in oncology using high throughput sequencing technologies. PMID:23251139

  9. Role of the U(1) ghost beyond leading order in a large-Nc expansion

    SciTech Connect

    Hrayr Matevosyan; Anthony Thomas

    2008-09-01

    The 1/Nc expansion is one of the very few methods we have for generating a systematic expansion of QCD at the energy scale relevant to hadron structure. The present formulation of this theory relies on 't Hooft's double-line notation for calculating the leading order of a diagram in the 1/Nc expansion, where the local SU(Nc) gauge symmetry is substituted by a U(Nc) symmetry and the associated U(1) ghost field is ignored. In the current work we demonstrate the insufficiency of this formulation for describing certain non-planar diagrams. We derive a more complete set of Feynman rules that include the U(1) ghost field and provide a useful tool for calculating both color factors and 1/Nc orders of given color-singlet diagrams.

  10. RTP AREA ROAD GRADE MEASUREMENTS

    EPA Science Inventory

    Grade data collection with GPS equipment is important because the load model component of the MEASURE model uses grade to predict the vehicle load. To date, data collection has been conducted for high priority roads and this task will include other roads not included in the firs...

  11. 75 FR 39250 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Protection Agency, Mail Code C304-06, Research Triangle Park, NC 27711; telephone: 919-541-2408; fax: 919-541... (40 FR 9407), EPA sought comments on this ICR pursuant to 5 CFR 1320.8(d). EPA received no comments... to, a collection of information, unless it displays a currently valid OMB control number. The...

  12. Testing the QCD string at large Nc from the thermodynamics of the hadronic phase

    NASA Astrophysics Data System (ADS)

    Cohen, Thomas D.

    2007-02-01

    It is generally believed that in the limit of a large number of colors (Nc) the description of confinement via flux tubes becomes valid and QCD can be modeled accurately via a hadronic string theory—at least for highly excited states. QCD at large Nc also has a well-defined deconfinement transition at a temperature Tc. In this talk it is shown how the thermodyanmics of the metastable hadronic phase of QCD (above Tc) at large NC can be related directly to properties of the effective QCD string. The key points in the derivation is the weakly interacting nature of hadrons at large Nc and the existence of a Hagedorn temperature TH for the effective string theory. From this it can be seen at large Nc and near TH, the energy density and pressure of the hadronic phase scale as E ˜ (TH - T)-(D⊥-6)/2 (for D⊥ < 6) and P ˜ (TH - T)-(D⊥-4)/2 (for D⊥ < 4) where D⊥ is the effective number of transverse dimensions of the string theory. This behavior for D⊥ < 6 is qualitatively different from typical models in statistical mechanics and if observed on the lattice would provide a direct test of the stringy nature of large Nc QCD. However since it can be seen that TH > Tc this behavior is of relevance only to the metastable phase. The prospect of using this result to extract D⊥ via lattice simulations of the metastable hadronic phase at moderately large Nc is discussed.

  13. 75 FR 30706 - Safety Zone; Wilson Bay, Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... Federal Register (75 FR 16703). We received no comments on the proposed rule. No public meeting was... hazards associated with low flying helicopters and vessels participating in this multi agency exercise... exercise participants from potential hazards associated with low flying helicopters and...

  14. 75 FR 16703 - Safety Zone; Wilson Bay, Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public... potential hazards associated with low flying helicopters and vessels participating in this multi agency... low flying helicopters and vessels participating in this multiagency exercise. An...

  15. Defect states in nc-Si:H films investigated by surface photovoltage spectroscopy

    SciTech Connect

    Cavalcoli, Daniela; Rossi, Marco; Cavallini, Anna

    2011-03-01

    Hydrogenated nanocrystalline silicon (nc-Si:H) is a multiphase, heterogeneous material, composed of Si nanocrystals embedded in an amorphous matrix. It has been intensively studied recently due to very promising photovoltaic and optoelectronics applications. The present paper aims to study electronic transitions in nc-Si:H grown by Low Energy Plasma Enhanced Chemical Vapor Deposition by Surface Photovoltage Spectroscopy. The study of several thin films grown at different conditions and the comparison with recently published computational studies allowed us to advance a hypothesis on the defect structure responsible for electronic transitions in nc-Si:H.

  16. Sources of suspended sediment in the Lower Roanoke River, NC

    NASA Astrophysics Data System (ADS)

    Jalowska, A. M.; McKee, B. A.; Rodriguez, A. B.; Laceby, J. P.

    2015-12-01

    The Lower Roanoke River, NC, extends 220 km from the fall line to the bayhead delta front in the Albemarle Sound. The Lower Roanoke is almost completely disconnected from the upper reaches by a series of dams, with the furthest downstream dam located at the fall line. The dams effectively restrict the suspended sediment delivery from headwaters, making soils and sediments from the Lower Roanoke River basin, the sole source of suspended sediment. In flow-regulated rivers, bank erosion, especially mass wasting, is the major contributor to the suspended matter. Additional sources of the suspended sediment considered in this study are river channel, surface soils, floodplain surface sediments, and erosion of the delta front and prodelta. Here, we examine spatial and temporal variations in those sources. This study combined the use of flow and grain size data with a sediment fingerprinting method, to examine the contribution of surface and subsurface sediments to the observed suspended sediment load along the Lower Roanoke River. The fingerprinting method utilized radionuclide tracers 210Pb (natural atmospheric fallout), and 137Cs (produced by thermonuclear bomb testing). The contributions of surface and subsurface sources to the suspended sediment were calculated with 95% confidence intervals using a Monte-Carlo numerical mixing model. Our results show that with decreasing river slope and changing hydrography along the river, the contribution of surface sediments increases and becomes a main source of sediments in the Roanoke bayhead delta. At the river mouth, the surface sediment contribution decreases and is replaced by sediments eroded from the delta front and prodelta. The area of high surface sediment contribution is within the middle and upper parts of the delta, which are considered net depositional. Our study demonstrates that floodplains, often regarded to be a sediment sink, are also a sediment source, and they should be factored into sediment, carbon and

  17. Adoption of Evidence-Based Interventions in Local Health Departments: "1-2-3 Pap NC".

    PubMed

    Winterbauer, Nancy L; Bridger, Colleen M; Tucker, Ashley; Rafferty, Ann P; Luo, Huabin

    2015-08-01

    Descriptions of barriers and facilitators to adoption of evidence-based interventions in local health departments (LHDs) are limited. This study was conducted by the North Carolina Public Health Practice-Based Research Network to identify factors associated with adoption of an evidence-based human papillomavirus video intervention, "1-2-3 Pap NC," in North Carolina LHDs. A sequential mixed-method study design was used. Data from the 2013 National Profile of Local Health Departments were used to test associations between LHD characteristics and adoption of the intervention. Qualitative, key stakeholder interviews with LHD directors provided the context for quantitative data. Data collection and analysis continued from March 3, 2014, to September 15, 2014. Overall, 28% of North Carolina health jurisdictions (33 of 100 counties) implemented the intervention. Of the three channels used to deliver the intervention to clients, most LHDs opted to show the video in the exam room (42%), followed by website/other social media (36%) and video loop in the lobby/waiting room (22%). In logistic regression, gender of the director (female) was significantly and positively associated with adoption of the intervention (AOR=4.44, p<0.05). Being a first-time director was marginally significant (AOR=0.28, p=0.074), suggesting first-time directors were less likely to adopt. Qualitative results suggested that aspects of communication (awareness and positive attitudes) and agency directors' evaluation of resources, balanced against intervention complexity and flexibility, competing priorities, and mandates, influenced adoption. Adoption of evidence-based interventions by LHDs is critical to improve population health. Practice-based research can contribute to understanding facilitators and modifying barriers to this process. PMID:26190805

  18. Highly conducting and preferred <220> oriented boron doped nc-Si films for window layers in nc-Si solar cells

    NASA Astrophysics Data System (ADS)

    Mondal, Praloy; Das, Debajyoti

    2016-05-01

    Growth and optimization of the boron dopednanocrystalline silicon (nc-Si) films have been studied by varyingthe gaspressure applied to the hydrogendiluted silane plasma in RF (13.56 MHz) plasma-enhanced chemical vapor deposition (PECVD) system, using diborane (B2H6) as the dopant gas. High magnitudeof electrical conductivity (~102 S cm-1) and<220>orientedcrystallographic lattice planes have been obtained with high crystalline volume fraction (~86 %) at an optimum pressure of 2.5 Torr. XRD and Raman studies reveal good crystallinity with preferred orientation, suitable for applications in stacked layer devices, particularly in nc-Si solar cells.

  19. 76 FR 53341 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... approximately 14 feet, above mean high water. On behalf of the City of New Bern NC, the National Multiple Sclerosis (MS) Society has requested a temporary deviation from the current operating regulations of...

  20. Geologic and hydrologic data collected at test hole NC-8, Vega Alta, Puerto Rico

    USGS Publications Warehouse

    Rodríguez-Martínez, Jesús; Scharlach, Richard A.

    1994-01-01

    Test hole NC-8 was drilled in the municipality of Vega Alta as part of a study of the aquifers in the Northern Coastal Province of Puerto Rico. Test hole NC-8 was drilled to a depth of 1,736 feet below land surface. Geologic and hydrologic data collected during drilling included continuous core, water- quality samples, water-level measurements, and estimates of aquifer yields from the water-bearing zones. Test hole NC-8 penetrated five geologic formations of middle Tertiary age: the Aymamon Limestone, the Los Puertos Formation, the Cibao Formation, the Lares Limestone, and the San Sebastian Formation. Test hole NC-8 penetrated a water-table aquifer and seven artesian aquifers.

  1. 75 FR 43816 - Amendment of Class E Airspace; Mount Airy, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ...This action amends Class E Airspace at Mount Airy, NC, to accommodate the additional airspace needed for the Standard Instrument Approach Procedures (SIAPs) developed for Mount Airy-Surry County...

  2. Time-reversal-invariance-violating nucleon-nucleon potential in the 1 /Nc expansion

    NASA Astrophysics Data System (ADS)

    Samart, Daris; Schat, Carlos; Schindler, Matthias R.; Phillips, Daniel R.

    2016-08-01

    We apply the large-Nc expansion to the time-reversal-invariance-violating (TV) nucleon-nucleon potential. The operator structures contributing to next-to-next-to-leading order in the large-Nc counting are constructed. For the TV and parity-violating case we find a single operator structure at leading order. The TV but parity-conserving potential contains two leading-order terms, which, however, are suppressed by 1 /Nc compared to the parity-violating potential. Comparison with phenomenological potentials, including the chiral effective field theory potential in the TV parity-violating case, leads to large-Nc scaling relations for TV meson-nucleon and nucleon-nucleon couplings.

  3. 77 FR 423 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway (AIWW), Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ..., NC. The deviation restricts the operation of the draw span to facilitate the structural repair of the.... Under this temporary deviation, the structural repairs will restrict the operation of the draw span...

  4. 75 FR 54024 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... the US70 (Alfred C. Cunningham) Bridge across Trent River, mile 0.0, at New Bern, NC, to accommodate a...-9826. SUPPLEMENTARY INFORMATION: The US70 (Alfred C. Cunningham) Bridge a bascule lift bridge...

  5. 77 FR 18105 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... the US 70 Alfred Cunningham Bridge across the Trent River, mile 0.0, at New Bern, NC. The deviation is... current operating regulation of the US 70 Alfred Cunningham Bascule Bridge across the Trent River, mile...

  6. Hydrodynamics of the Polyakov line in SU(Nc) Yang-Mills

    NASA Astrophysics Data System (ADS)

    Liu, Yizhuang; Warchoł, Piotr; Zahed, Ismail

    2016-02-01

    We discuss a hydrodynamical description of the eigenvalues of the Polyakov line at large but finite Nc for Yang-Mills theory in even and odd space-time dimensions. The hydro-static solutions for the eigenvalue densities are shown to interpolate between a uniform distribution in the confined phase and a localized distribution in the de-confined phase. The resulting critical temperatures are in overall agreement with those measured on the lattice over a broad range of Nc, and are consistent with the string model results at Nc = ∞. The stochastic relaxation of the eigenvalues of the Polyakov line out of equilibrium is captured by a hydrodynamical instanton. An estimate of the probability of formation of a Z (Nc) bubble using a piece-wise sound wave is suggested.

  7. Bidirectional expression of long ncRNA/protein-coding gene pairs in cancer.

    PubMed

    Albrecht, Anne-Susann; Ørom, Ulf Andersson

    2016-05-01

    Bidirectional initiation of transcription by RNA polymerase II occurs prevalently at active promoters during protein-coding gene (PCG) expression. Upstream, antisense noncoding RNAs (ncRNAs) of differing lengths, stabilities and processings are being expressed from these promoters in concert with downstream, processive messenger RNA transcription. Although abundantly detected, the functional role and regulatory capacity of such transcripts have only been determined for individual cases. Long ncRNAs in general are reportedly able to regulate all steps of the gene expression process. Therefore, to get insight into the functionality of long ncRNAs transcribed bidirectionally from cancer-associated PCGs is of interest, as expression changes of tumor suppressor genes and oncogenes are prevalent in cancer.Here, we review the sources and characteristics of antisense transcription occurring at PCG loci in the human genome, and focus on the functional impact of bidirectional long ncRNA expression at cancer-associated PCGs. PMID:26578749

  8. 78 FR 18848 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ..., NC. This deviation is necessary to accommodate the 6th annual PPD Beach2Battleship iron and half iron... be closed to navigation to accommodate the 6th annual PPD Beach2Battleship iron and half...

  9. 75 FR 54023 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Camp Lejeune, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Lejeune, NC. The deviation is necessary to facilitate urgent replacement of the main hydraulic system... hydraulic system. Under this temporary deviation, the Onslow Beach Swing Bridge will be maintained in...

  10. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  11. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  12. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  13. 76 FR 72309 - Drawbridge Operation Regulation; Neuse River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... drawbridge operation regulation for the U.S. 17 bridge across Neuse River, mile 33.7 at New Bern, NC. The... Neuse River, mile 33.7, at New Bern, NC was removed and replaced with a fixed bridge in 1999. It has... part 117 continues to read as follows: Authority: 33 U.S.C. 499; 33 CFR 1.05-1; Department of...

  14. Anion-Dependent Aggregate Formation and Charge Behavior of Colloidal Fullerenes (n-C60)

    NASA Astrophysics Data System (ADS)

    Mukherjee, B.; Weaver, J. W.

    2009-12-01

    The fate and transport of colloidal fullerenes (n-C60) in the environment are likely to be guided by their electrokinetic and aggregation behavior. In natural water bodies inorganic ions exert significant effects in determining the size and charge of dispersed n-C60. Although the effects of cations on the behavior of n-C60 have been studied extensively; studies on the effect of anions are relatively few and thus were the focus of our investigation. The effects of anions (e.g., Cl- , SO42-) on average aggregate size (DH) and zeta potential (ZP) of n-C60 were found to be absent in presence of monovalent cations (e.g., Na+) over the tested range of pH (3-to-12) and ionic strength (0-to-20 mM). Similar observations were noted in the presence of multivalent cations (e.g., Mg2+) near acidic and neutral pH conditions. However, under alkaline conditions (pH~10) a strong anion-dependent reversal of surface charge was noted. The ZP of n-C60 changed from -65 mV, when dispersed in DI water, to +4 mV and +40 mV in the presence of SO42- and Cl-, respectively in a 10mM salt concentration (i.e., MgCl2 and MgSO4). The corresponding DH of the dispersed n-C60 changed simultaneously from 115 nm, in DI water, to 1450 nm and 225 nm for the MgSO4 and MgCl2 electrolytes. These findings provide a better understanding of interfacial interaction characteristics of n-C60 NPs, and may lead to remediation strategies for n-C60 NPs in the environment.

  15. Investigation of Gd3N@C2n (40 n 44) family by Raman and inelastic electron tunneling spectroscopy

    SciTech Connect

    Burke, Brian; Chan, Jack; Williams, Keith A; Ge, Jiechao; Shu, Chunying; Fu, Wujun; Dorn, Harry C; Kushmerick, James G; Puretzky, Alexander A; Geohegan, David B

    2010-01-01

    The structure and vibrational spectrum of Gd3N@C80 is studied through Raman and inelastic electron tunneling spectroscopy as well as density-functional theory and universal force eld calculations. Hindered rotations, shown by both theory and experiment, indicate the formation of a Gd3N-C80 bond which reduces the ideal icosahedral symmetry of the C80 cage. The vibrational modes involving the movement of the encapsulated species are a ngerprint of the interaction between the fullerene cage and the core complex. We present Raman data for the Gd3N@C2n 40 n 44 family as well as Y3N@C80, Lu3N@C80, and Y3N@C88 for comparison. Conductance measurements have been performed on Gd3N@C80 and reveal a Kondo effect similar to that observed in C60.

  16. A novel denitrifying methanotroph of the NC10 phylum and its microcolony

    PubMed Central

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S. M.; Hu, Baolan

    2016-01-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it ‘Candidatus Methylomirabilis sinica’ (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7–1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25–0.5 × 0.8–1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies. PMID:27582299

  17. Secondary Structure and Secondary Structure Dynamics of DNA Hairpins Complexed with HIV-1 NC Protein

    PubMed Central

    Cosa, Gonzalo; Harbron, Elizabeth J.; Zeng, Yining; Liu, Hsiao-Wei; O'Connor, Donald B.; Eta-Hosokawa, Chie; Musier-Forsyth, Karin; Barbara, Paul F.

    2004-01-01

    Reverse transcription of the HIV-1 RNA genome involves several complex nucleic acid rearrangement steps that are catalyzed by the HIV-1 nucleocapsid protein (NC), including for example, the annealing of the transactivation response (TAR) region of the viral RNA to the complementary region (TAR DNA) in minus-strand strong-stop DNA. We report herein single-molecule fluorescence resonance energy transfer measurements on single immobilized TAR DNA hairpins and hairpin mutants complexed with NC (i.e., TAR DNA/NC). Using this approach we have explored the conformational distribution and dynamics of the hairpins in the presence and absence of NC protein. The data demonstrate that NC shifts the equilibrium secondary structure of TAR DNA hairpins from a fully “closed” conformation to essentially one specific “partially open” conformation. In this specific conformation, the two terminal stems are “open” or unwound and the other stems are closed. This partially open conformation is arguably a key TAR DNA intermediate in the NC-induced annealing mechanism of TAR DNA. PMID:15454467

  18. The baryon vector current in the combined chiral and 1/Nc expansions

    SciTech Connect

    Flores-Mendieta, Ruben; Goity, Jose L

    2014-12-01

    The baryon vector current is computed at one-loop order in large-Nc baryon chiral perturbation theory, where Nc is the number of colors. Loop graphs with octet and decuplet intermediate states are systematically incorporated into the analysis and the effects of the decuplet-octet mass difference and SU(3) flavor symmetry breaking are accounted for. There are large-Nc cancellations between different one-loop graphs as a consequence of the large-Nc spin-flavor symmetry of QCD baryons. The results are compared against the available experimental data through several fits in order to extract information about the unknown parameters. The large-Nc baryon chiral perturbation theory predictions are in very good agreement both with the expectations from the 1/Nc expansion and with the experimental data. The effect of SU(3) flavor symmetry breaking for the |Delta S|=1 vector current form factors f1(0) results in a reduction by a few percent with respect to the corresponding SU(3) symmetric values.

  19. A novel denitrifying methanotroph of the NC10 phylum and its microcolony.

    PubMed

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S M; Hu, Baolan

    2016-01-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species 'Candidatus Methylomirabilis oxyfera' (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it 'Candidatus Methylomirabilis sinica' (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7-1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25-0.5 × 0.8-1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies. PMID:27582299

  20. The Hilbert series of N=1SO(Nc) and Sp(Nc) SQCD, Painlevé VI and integrable systems

    NASA Astrophysics Data System (ADS)

    Basor, Estelle; Chen, Yang; Mekareeya, Noppadol

    2012-07-01

    We present a novel approach for computing the Hilbert series of 4d N=1 supersymmetric QCD with SO(Nc) and Sp(Nc) gauge groups. It is shown that such Hilbert series can be recast in terms of determinants of Hankel matrices. With the aid of results from random matrix theory, such Hankel determinants can be evaluated both exactly and asymptotically. Several new results on Hilbert series for general numbers of colours and flavours are thus obtained in this paper. We show that the Hilbert series give rise to families of rational solutions, with palindromic numerators, to the Painlevé VI equations. Due to the presence of such Painlevé equations, there exist integrable Hamiltonian systems that describe the moduli spaces of SO(Nc) and Sp(Nc) SQCD. To each system, we explicitly state the corresponding Hamiltonian and family of elliptic curves. It turns out that such elliptic curves take the same form as the Seiberg-Witten curves for 4d N=2SU(2) gauge theory with 4 flavours.

  1. Link between the potentially hazardous Asteroid (86039) 1999 NC43 and the Chelyabinsk meteoroid tenuous

    NASA Astrophysics Data System (ADS)

    Reddy, Vishnu; Vokrouhlický, David; Bottke, William F.; Pravec, Petr; Sanchez, Juan A.; Gary, Bruce L.; Klima, Rachel; Cloutis, Edward A.; Galád, Adrián; Guan, Tan Thiam; Hornoch, Kamil; Izawa, Matthew R. M.; Kušnirák, Peter; Le Corre, Lucille; Mann, Paul; Moskovitz, Nicholas; Skiff, Brian; Vraštil, Jan

    2015-05-01

    We explored the statistical and compositional link between Chelyabinsk meteoroid and potentially hazardous Asteroid (86039) 1999 NC43 to investigate their proposed relation proposed by Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237). First, using a slightly more detailed computation we confirm that the orbit of the Chelyabinsk impactor is anomalously close to the Asteroid 1999 NC43. We find ∼(1-3) × 10-4 likelihood of that to happen by chance. Taking the standpoint that the Chelyabinsk impactor indeed separated from 1999 NC43 by a cratering or rotational fission event, we run a forward probability calculation, which is an independent statistical test. However, we find this scenario is unlikely at the ∼(10-3-10-2) level. Secondly, we note that efforts to conclusively prove separation of the Chelyabinsk meteoroid from (86039) 1999 NC43 in the past needs to meet severe criteria: relative velocity ≃1-10 m/s or smaller, and ≃100 km distance (i.e. about the Hill sphere distance from the parent body). We conclude that, unless the separation event was an extremely recent event, these criteria present an insurmountable difficulty due to the combination of strong orbital chaoticity, orbit uncertainty and incompleteness of the dynamical model with respect to thermal accelerations. This situation leaves the link of the two bodies unresolved and calls for additional analyses. With that goal, we revisit the presumed compositional link between (86039) 1999 NC43 and the Chelyabinsk body. Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237) noted that given its Q-type taxonomic classification, 1999 NC43 may pass this test. However, here we find that while the Q-type classification of 1999 NC43 is accurate, assuming that all Q-types are LL chondrites is not. Our experiment shows that not all ordinary chondrites fall under Q-taxonomic type and not all LL chondrites are Q-types. Spectral curve matching between laboratory spectra of

  2. EPA (ENVIRONMENTAL PROTECTION AGENCY) WORKSHOP ON N2O EMISSION FROM COMBUSTION (DURHAM, NC., FEBRUARY 13-14, 1986)

    EPA Science Inventory

    The report summarizes the dialogue and interaction which took place during an EPA sponsored workshop addressing nitrous oxide (N20) emissions from fossil fuel combustion. Prior research had identified N20 as a trace gas potentially contributing to depletion of stratospheric ozone...

  3. Testing the QCD string at large Nc from the thermodynamics of the hadronic phase

    SciTech Connect

    Cohen, Thomas D.

    2007-02-27

    It is generally believed that in the limit of a large number of colors (Nc) the description of confinement via flux tubes becomes valid and QCD can be modeled accurately via a hadronic string theory-at least for highly excited states. QCD at large Nc also has a well-defined deconfinement transition at a temperature Tc. In this talk it is shown how the thermodyanmics of the metastable hadronic phase of QCD (above Tc) at large NC can be related directly to properties of the effective QCD string. The key points in the derivation is the weakly interacting nature of hadrons at large Nc and the existence of a Hagedorn temperature TH for the effective string theory. From this it can be seen at large Nc and near TH, the energy density and pressure of the hadronic phase scale as E {approx} (TH - T)-(D perpendicular -6)/2 (for D perpendicular < 6) and P {approx} (TH - T)-(D perpendicular -4)/2 (for D perpendicular < 4) where D perpendicular s the effective number of transverse dimensions of the string theory. This behavior for D perpendicular < 6 is qualitatively different from typical models in statistical mechanics and if observed on the lattice would provide a direct test of the stringy nature of large Nc QCD. However since it can be seen that TH > Tc this behavior is of relevance only to the metastable phase. The prospect of using this result to extract D perpendicular via lattice simulations of the metastable hadronic phase at moderately large Nc is discussed.

  4. Improved PCR primers to amplify 16S rRNA genes from NC10 bacteria.

    PubMed

    He, Zhanfei; Wang, Jiaqi; Hu, Jiajie; Zhang, Hao; Cai, Chaoyang; Shen, Jiaxian; Xu, Xinhua; Zheng, Ping; Hu, Baolan

    2016-06-01

    Anaerobic oxidation of methane (AOM) coupled to nitrite reduction (AOM-NIR) is ecologically significant for mitigating the methane-induced greenhouse effect. The microbes responsible for this reaction, NC10 bacteria, have been widely detected in diverse ecosystems. However, some defects were discovered in the commonly used NC10-specific primers, 202F and qP1F. In the present work, the primers were redesigned and improved to overcome the defects found in the previous primers. A new nested PCR method was developed using the improved primers to amplify 16S ribosomal RNA (rRNA) genes from NC10 bacteria. In the new nested PCR method, the qP1mF/1492R and 1051F/qP2R primer sets were used in the first and second rounds, respectively. The PCR products were sequenced, and more operational taxonomic units (OTUs) of the NC10 phylum were obtained using the new primers compared to the previous primers. The sensitivity of the new nested PCR was tested by the serial dilution method, and the limit of detection was approximately 10(3) copies g(-1) dry sed. for the environmental samples compared to approximately 10(5) copies g(-1) dry sed. by the previous method. Finally, the improved primer, qP1mF, was used in quantitative PCR (qPCR) to determine the abundance of NC10 bacteria, and the results agreed well with the activity of AOM-NIR measured by isotope tracer experiments. The improved primers are able to amplify NC10 16S rRNA genes more efficiently than the previous primers and useful to explore the microbial community of the NC10 phylum in different systems. PMID:27020287

  5. Parity-violating nucleon-nucleon force in the 1/N(c) expansion.

    PubMed

    Phillips, Daniel R; Samart, Daris; Schat, Carlos

    2015-02-13

    Several experimental investigations have observed parity violation (PV) in nuclear systems-a consequence of the weak force between quarks. We apply the 1/N(c) expansion of QCD to the P-violating T-conserving component of the nucleon-nucleon (NN) potential. We show there are two leading-order operators, both of which affect p[over →]p scattering at order N(c). We find an additional four operators at order N(c)(0)sin(2)θ(W) and six at O(1/N(c)). Pion exchange in the PV NN force is suppressed by 1/N(c) and sin(2)θ(W), providing a quantitative explanation for its nonobservation up to this time. The large-N(c) hierarchy of other PV NN force mechanisms is consistent with estimates of the couplings in phenomenological models. The PV observed in p[over →]p scattering data is compatible with natural values for the strong and weak coupling constants: there is no evidence of fine-tuning. PMID:25723213

  6. Polarization memory effect in the photoluminescence of nc-Si-SiOx light-emitting structures

    NASA Astrophysics Data System (ADS)

    Michailovska, Katerina; Indutnyi, Ivan; Shepeliavyi, Petro; Sopinskyy, Mykola

    2016-06-01

    The polarization memory (PM) effect in the photoluminescence (PL) of the porous nc-Si-SiOx light-emitting structures, containing nanoparticles of silicon (nc-Si) in the oxide matrix and passivated in a solution of hydrofluoric acid (HF), has been investigated. The studied nc-Si-SiOx structures were produced by evaporation of Si monoxide (SiO) powder in vacuum and oblique deposition on Si wafer, and then the deposited silicon oxide (SiOx) films were annealed in the vacuum at 975 °C to grow nc-Si. It was found that the PM effect in the PL is observed only after passivation of nanostructures: during etching in HF solution, the initial symmetric nc-Si becomes asymmetric elongated. It was also found that in investigated nanostructures, there is a defined orientational dependence of the PL polarization degree ( ρ) in the sample plane which correlates with the orientation of SiOx nanocolumns, forming the structure of the porous layer. The increase of the ρ values in the long-wavelength spectral range with time of HF treatment can be associated with increasing of the anisotropy of large Si nanoparticles. The PM effect for this spectral interval can be described by the dielectric model. In the short-wavelength spectral range, the dependence of the ρ values agrees qualitatively with the quantum confinement effect.

  7. Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.

    PubMed

    Shibamori, Masafumi; Ogino, Keiki; Kambayashi, Yasuhiro; Ishiyama, Hironobu

    2006-01-25

    Airway responses induced by intranasal administration of mite allergen without adjuvant were studied in NC/Nga mice. A crude extract of Dermatophagoides farinae (Df) was administered for 5 consecutive days and a single intranasal challenge booster dose was given 1 week after the last sensitization. 24 h after the single challenge, the airway hyperresponsiveness (AHR) was measured and the bronchoalveolar lavage fluid (BALF) was analyzed for numbers of eosinophils and neutrophils, and both cytokine and chemokine levels. There were marked increases in number of eosinophils in the BALF, AHR, Th2 cytokines (IL-5 and IL-13), and chemokine (eotaxin-1 and eotaxin-2) levels in the BALF following Df exposure. C57BL/6N, A/J, BALB/c, and CBA/JN mouse strains were also exposed to Df crude extract, but all of the measured responses were strongest in NC/Nga mice. Furthermore, Df-exposed NC/Nga mice showed the goblet cell hyperplasia, pulmonary eosinophilic inflammation, and increases in both total serum IgE and Df-specific IgG1. After intranasal exposure of NC/Nga mice to crude extract of Dermatophagoides pteronyssinus, the BALF eosinophilia and AHR were similar to responses induced by Df. None of the study parameters were increased in response to intranasal exposure to ovalbumin. These data demonstrated that NC/Nga mice developed allergic asthma-like responses after intranasal exposure to mite allergens. PMID:16229861

  8. Polarization memory effect in the photoluminescence of nc-Si-SiOx light-emitting structures.

    PubMed

    Michailovska, Katerina; Indutnyi, Ivan; Shepeliavyi, Petro; Sopinskyy, Mykola

    2016-12-01

    The polarization memory (PM) effect in the photoluminescence (PL) of the porous nc-Si-SiOx light-emitting structures, containing nanoparticles of silicon (nc-Si) in the oxide matrix and passivated in a solution of hydrofluoric acid (HF), has been investigated. The studied nc-Si-SiOx structures were produced by evaporation of Si monoxide (SiO) powder in vacuum and oblique deposition on Si wafer, and then the deposited silicon oxide (SiOx) films were annealed in the vacuum at 975 °C to grow nc-Si. It was found that the PM effect in the PL is observed only after passivation of nanostructures: during etching in HF solution, the initial symmetric nc-Si becomes asymmetric elongated. It was also found that in investigated nanostructures, there is a defined orientational dependence of the PL polarization degree (ρ) in the sample plane which correlates with the orientation of SiOx nanocolumns, forming the structure of the porous layer. The increase of the ρ values in the long-wavelength spectral range with time of HF treatment can be associated with increasing of the anisotropy of large Si nanoparticles. The PM effect for this spectral interval can be described by the dielectric model. In the short-wavelength spectral range, the dependence of the ρ values agrees qualitatively with the quantum confinement effect. PMID:27255897

  9. Baryons at Varying Nc: a study with Lattice QCD and Effective Theory

    NASA Astrophysics Data System (ADS)

    Goity, Jose; Calle Cordon, Alvaro; Degrand, Thomas

    2013-10-01

    Recent Lattice QCD (LQCD) calculations of baryon masses with the number of colors Nc = 3 , 5 and 7 have opened the opportunity for exploring quantitatively the 1 /Nc expansion of QCD in the baryon sector. While similar studies have been carried out for glueballs and mesons, which show a remarkably well behaved 1 /Nc expansion down to the real world's Nc = 3 , the results in are the first ones of their kind. The calculations were performed in quenched LQCD and with quark masses giving Mπ > 400 MeV. The results are analyzed using an Effective Theory based on the combination of Baryon Chiral Perturbation Theory and the 1 /Nc expansion. A detailed discussion of the analysis and its implications will be presented, along the lines of a current work in progress. Work supported by DOE Contract No. DEAC05- 06OR23177 under which JSA operates the Thomas Jefferson National Accelerator Facility, by DOE grant DE-FG02-04ER41290, and by NSF grants PHY-0855789 and PHY-1307413.

  10. nC60 deposition kinetics: the complex contribution of humic acid, ion concentration, and valence.

    PubMed

    McNew, Coy P; LeBoeuf, Eugene J

    2016-07-01

    The demonstrated toxicity coupled with inevitable environmental release of nC60 raise serious concerns about its environmental fate and transport, therefore it is crucial to understand how nC60 will interact with subsurface materials including attached phase soil and sediment organic matter (AP-SOM). This study investigated the attachment of nC60 onto a Harpeth humic acid (HHA) coated silica surface under various solution conditions using a quartz crystal microbalance with dissipation monitoring. The HHA coating greatly enhanced nC60 attachment at low ion concentrations while hindering attachment at high ion concentrations in the presence of both mono and divalent cations. At low ion concentrations, the HHA greatly reduced the surface potential of the silica, enhancing nC60 deposition through reduction in the electrostatic repulsion. At high ion concentrations however, the reduced surface potential became less important due to the near zero energy barrier to deposition and therefore non-DLVO forces dominated, induced by compaction of the HHA layer, and leading to hindered attachment. In this manner, observed contributions from the HHA layer were more complex than previously reported and by monitoring surface charge and calculated DLVO interaction energy alongside attachment experiments, this study advances the mechanistic understanding of the variable attachment contributions from the humic acid layer. PMID:27061365

  11. Kinetic models of the interference of gene transcription to ncRNA and mRNA

    NASA Astrophysics Data System (ADS)

    Zhdanov, Vladimir P.

    2011-06-01

    The experiments indicate that the transcription of genes into ncRNA can positively or negatively interfere with transcription into mRNA. We propose two kinetic models describing this effect. The first model is focused on the ncRNA-induced chromatin modification facilitating the transcription of the downstream gene into mRNA. The second model includes the competition between the transcription into ncRNA and the binding of activator to a regulatory site of the downstream gene transcribed into mRNA. Our analysis based on the mean-field kinetic equations and Monte Carlo simulations shows the likely dependences of the transcription rate on RNA polymerase concentration in situations with different rate-limiting steps. Our models can also be used to scrutinize the dependence of the transcription rate on other kinetic parameters. Our kinetic Monte Carlo simulations show that the first model predicts stochastic bursts in the mRNA formation provided that the transcription into ncRNA is slow, while the second model predicts in addition anti-phase stochastic bursts in the mRNA and ncRNA formation provided that that the protein attachment to and detachment from a regulatory site is slow.

  12. Dirac form factors and electric charge radii of baryons in the combined chiral and 1 /Nc expansions

    NASA Astrophysics Data System (ADS)

    Flores-Mendieta, Rubén; Rivera-Ruiz, Mayra Alejandra

    2015-11-01

    The baryon Dirac form factor is computed at one-loop order in large-Nc baryon chiral perturbation theory, where Nc is the number of color charges. Loop graphs with octet and decuplet intermediate states are systematically incorporated into the analysis and the effects of the decuplet-octet mass difference are accounted for. There are large-Nc cancellations between different one-loop graphs as a consequence of the large-Nc spin-flavor symmetry of QCD baryons. As a byproduct, the mean-square charge radius is also computed through a detailed numerical analysis. The predictions of large-Nc baryon chiral perturbation theory are in very good agreement both with the expectations from the 1 /Nc expansion and with the experimental data.

  13. Fluorinated noble-gas cyanides FKrCN, FXeCN, and FXeNC

    SciTech Connect

    Zhu, Cheng; Räsänen, Markku; Khriachtchev, Leonid

    2015-08-21

    We report on three new noble-gas molecules, FKrCN, FXeCN, and FXeNC, prepared in low-temperature Kr and Xe matrices. These molecules are made by UV photolysis of FCN in the matrices and subsequent thermal annealing. The FCN precursor is produced by deposition of the matrix gas containing (FCN){sub 3} through a microwave discharge. The new noble-gas molecules are assigned with the help of quantum chemical calculations at the MP2(full) and CCSD(T) levels of theory. Similar Ar compounds (FArCN and FArNC) as well as FKrNC are not found in these experiments, which is in agreement with the calculated energetics.

  14. A Search for Neutrino Induced Coherent NC($\\pi^{0}$) Production in the MINOS Near Detector

    SciTech Connect

    Cherdack, Daniel David; /Tufts U.

    2010-11-01

    The production of single, highly forward {pi}{sup 0} mesons by NC coherent neutrino-nucleus interactions ({nu}{sub {mu}} + N {yields} {nu}{sub {mu}} + N + {pi}{sup 0}) is a process which probes fundamental aspects of the weak interaction. This reaction may also pose as a limiting background for long baseline searches for {nu}{sub {mu}} {yields} {nu}{sub e} oscillations if the neutrino mixing angle {theta}{sub 13} is very small. The high-statistics sample of neutrino interactions recorded by the MINOS Near Detector provides an opportunity to measure the cross section of this coherent reaction on a relatively large-A nucleus at an average E{sub {nu}} = 4.9 GeV. A major challenge for this measurement is the isolation of forward-going electromagnetic (EM) showers produced by the relatively rare coherent NC({pi}{sup 0}) process amidst an abundant rate of incoherently produced EM showers. The backgrounds arise from single {pi}{sup 0} dominated NC events and also from quasi-elastic-like CC scattering of electron neutrinos. In this Thesis the theory of coherent interactions is summarized, and previous measurements of the coherent NC({pi}{sup 0}) cross section are reviewed. Then, methods for selecting a sample of coherent NC({pi}{sup 0}) like events, extracting the coherent NC({pi}{sup 0}) event rate from that sample, estimating the analysis uncertainties, and calculating a cross section, are presented. A signal for neutrino-induced NC({pi}{sup 0}) production is observed in the relevant kinematic regime as an excess of events of three standard deviations above background. The reaction cross sections, averaged over an energy window of 2.5 {<=} E{sub {nu}} {<=} 9.0 GeV is determined to be (31.6{+-}10.5) x 10{sup -40} cm{sup 2}/nucleus. The result is the first evidence obtained for neutrino-nucleus coherent NC({pi}{sup 0}) scattering on iron, and is the first measurement on an average nuclear target above A = 30. The cross section measurement is in agreement with NEUGEN3

  15. Ab initio study on electronically excited states of lithium isocyanide, LiNC

    NASA Astrophysics Data System (ADS)

    Yasumatsu, Hisato; Jeung, Gwang-Hi

    2014-01-01

    The electronically excited states of the lithium isocyanide molecule, LiNC, were studied by means of ab initio calculations. The bonding nature of LiNC up to ˜10 eV is discussed on the basis of the potential energy surfaces according to the interaction between the ion-pair and covalent states. The ion-pair states are described by Coulomb attractive interaction in the long distance range, while the covalent ones are almost repulsive or bound with a very shallow potential dent. These two states interact each other to form adiabatic potential energy surfaces with non-monotonic change in the potential energy with the internuclear distance.

  16. Accounting for Agency

    ERIC Educational Resources Information Center

    Valentine, Kylie

    2011-01-01

    Children are increasingly described as agents and agency is important to arguments for children's rights and participation. Yet agency is rarely defined or theorised in childhood studies. This article reviews common uses and meanings of agency and argues that critical, social conceptualisations have yet to be extensively taken up in childhood…

  17. 40 CFR 36.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Federal agency or agency. 36.645 Section 36.645 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... Federal agency or agency. Federal agency or agency means any United States executive department,...

  18. Tetrastatin, the NC1 Domain of the α4(IV) Collagen Chain: A Novel Potent Anti-Tumor Matrikine

    PubMed Central

    Brassart-Pasco, Sylvie; Sénéchal, Karine; Thevenard, Jessica; Ramont, Laurent; Devy, Jérome; Di Stefano, Ludivine; Dupont-Deshorgue, Aurélie; Brézillon, Stéphane; Feru, Jezabel; Jazeron, Jean-François; Diebold, Marie-Danièle; Ricard-Blum, Sylvie; Maquart, François-Xavier; Monboisse, Jean Claude

    2012-01-01

    Background NC1 domains from α1, α2, α3 and α6(IV) collagen chains were shown to exert anti-tumor or anti-angiogenic activities, whereas the NC1 domain of the α4(IV) chain did not show such activities so far. Methodology/Principal Findings We demonstrate in the present paper that the NC1 α4(IV) domain exerts a potent anti-tumor activity both in vitro and in an experimental human melanoma model in vivo. The overexpression of NC1 α4(IV) in human UACC-903 melanoma cells strongly inhibited their in vitro proliferative (–38%) and invasive (–52%) properties. MT1-MMP activation was largely decreased and its cellular distribution was modified, resulting in a loss of expression at the migration front associated with a loss of migratory phenotype. In an in vivo xenograft model in athymic nude mice, the subcutaneous injection of NC1 α4(IV)-overexpressing melanoma cells induced significantly smaller tumors (–80% tumor volume) than the Mock cells, due to a strong inhibition of tumor growth. Exogenously added recombinant human NC1 α4(IV) reproduced the inhibitory effects of NC1 α4(IV) overexpression in UACC-903 cells but not in dermal fibroblasts. An anti-αvβ3 integrin blocking antibody inhibited cell adhesion on recombinant human NC1 α4(IV) substratum. The involvement of αvβ3 integrin in mediating NC1 α4(IV) effect was confirmed by surface plasmon resonance (SPR) binding assays showing that recombinant human NC1 α4(IV) binds to αvβ3 integrin (KD = 148±9.54 nM). Conclusion/Significance Collectively, our results demonstrate that the NC1 α4(IV) domain, named tetrastatin, is a new endogenous anti-tumor matrikine. PMID:22539938

  19. 77 FR 35843 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), at Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    .... Holmes Bridge across the Northeast Cape Fear River, mile 1.0; both at Wilmington, NC. The deviation is... across the Cape Fear River, mile 26.8; and the Isabel S. Holmes Bridge across the Northeast Cape Fear... S. Holmes Bridge is a double-leaf bascule drawbridge with a vertical clearance of 40 feet,...

  20. 77 FR 25652 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), at Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... Act notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR... Bridge across the Cape Fear River, mile 26.8; and the Isabel S. Holmes Bridge across the Northeast Cape... Isabel S. Holmes Bridge both at Wilmington, NC are located at 33 CFR 117.821(a)(4), 33 CFR 117.823,...

  1. 77 FR 50376 - Drawbridge Operation Regulation, Atlantic Intracoastal Waterway (AIWW); Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and... Fear River, at Wilmington NC'' in the Federal Register (77 FR 25652). We received no comments on the..., mile 26.8; and the Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile 1.0; both...

  2. PARTICULATE CHARACTERISTICS AND VISUAL EFFECTS OF THE ATMOSPHERE AT RESEARCH TRIANGLE PARK, NC

    EPA Science Inventory

    During a one-month period in the fall of 1987 a wide range in the visual quality of the atmosphere at Research Triangle Park, NC, was observed. uring this period, the light scatter coefficient; SO2, NO2, and O3 concentrations; temperature; relative humidity; and radiation intensi...

  3. 33 CFR 334.440 - New River, N.C., and vicinity; Marine Corps firing ranges.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...; Marine Corps firing ranges. 334.440 Section 334.440 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.C., and vicinity; Marine Corps firing ranges. (a) Atlantic Ocean east of New River Inlet. The... been published in the local notice to mariners and has been broadcast over the Marine Band...

  4. 33 CFR 334.440 - New River, N.C., and vicinity; Marine Corps firing ranges.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...; Marine Corps firing ranges. 334.440 Section 334.440 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.C., and vicinity; Marine Corps firing ranges. (a) Atlantic Ocean east of New River Inlet. The... been published in the local notice to mariners and has been broadcast over the Marine Band...

  5. 33 CFR 334.440 - New River, N.C., and vicinity; Marine Corps firing ranges.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...; Marine Corps firing ranges. 334.440 Section 334.440 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.C., and vicinity; Marine Corps firing ranges. (a) Atlantic Ocean east of New River Inlet. The... been published in the local notice to mariners and has been broadcast over the Marine Band...

  6. Eta(') mass and chiral symmetry breaking at large N(c) and N(f).

    PubMed

    Girlanda, L; Stern, J; Talavera, P

    2001-06-25

    We propose a method for implementing the large- N(c), large-N(f) limit of QCD at the effective Lagrangian level. Depending on the value of the ratio N(f)/N(c), different patterns of chiral symmetry breaking can arise, leading in particular to different behaviors of the eta(') mass in the combined large-N limit. PMID:11415379

  7. 78 FR 40394 - Safety Zone; Outer Banks Bluegrass Festival; Shallowbag Bay, Manteo, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... May 17, 2013 (78 FR 29091. We received no comments on the proposed rules. B. Basis and Purpose On... establishing of a temporary safety zone on Shallowbag Bay, Manteo, NC on October 4, 2013, for a fireworks... Fireworks display. DATES: This rule is effective August 5, 2013. ADDRESSES: Documents mentioned in...

  8. 75 FR 54771 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Bridge Run. This deviation allows the drawbridge to be maintained in the closed position to vessels at... behalf of the Neuse River Bridge Run Organization and the City of New Bern NC, the North Carolina... the bridge set out in 33 CFR 117.843 (a) to accommodate the Bridge Run schedule for Saturday,...

  9. 75 FR 14381 - Amendment of Class E Airspace; Mount Airy, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ...This action proposes to amend Class E Airspace at Mount Airy, NC, to accommodate the additional airspace needed for the Standard Instrument Approach Procedures (SIAPs) developed for Mount Airy-Surry County Airport. This action enhances the safety and airspace management of Instrument Flight Rules (IFR) operations at the...

  10. 76 FR 31510 - Proposed Amendment of Class E Airspace; Rutherfordton, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ...This action proposes to amend Class E Airspace at Rutherfordton, NC, to accommodate the additional airspace needed for the Standard Instrument Approach Procedures (SIAPs) developed for Rutherford County Airport. This action would enhance the safety and airspace management of Instrument Flight Rules (IFR) operations at the...

  11. 76 FR 35799 - Proposed Amendment of Class E Airspace; Shelby, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Shelby, NC...

  12. Density of saturated nuclear matter at large Nc and heavy quark mass limits

    NASA Astrophysics Data System (ADS)

    Adhikari, Prabal; Cohen, Thomas D.; Datta, Ishaun

    2014-06-01

    We exhibit the existence of stable, saturated nuclear matter in the large Nc and heavy quark mass limits of QCD. In this limit, baryons (with the same spin flavor structure) interact at leading order in Nc via a repulsive interaction due to the Pauli exclusion principle and at subleading order in 1/Nc via the exchange of glueballs. Assuming that the lightest glueball is a scalar, which implies that the subleading baryon interaction is attractive, we find that nuclear matter saturates since the subleading attractive interaction is longer ranged than the leading order repulsive one. We find that the saturated matter is in the form of a crystal with either a face-centered-cubic or a hexagonal-close-packed symmetry with baryon densities of O ({α˜smq[Nc limit or heavy quark limit (or both), which we define precisely in this work.

  13. [Temperature-Dependent Photoluminescence Property Studies of SiN(x) Films with nc-Si].

    PubMed

    Liu, Jian-ping; Zheng, Yan; Liu, Hai-xu; Yu, Wei; Ding, Wen-ge; Lai, Wei-dong

    2016-03-01

    Silicon nitride (SiN(x)) films containing nanocrystalline silicon (nc-Si) were deposited on crystalline silicon substrate by facing-target sputtering technique. Thermal annealing process was performed at 450 degrees C for 50 min in a conventional furnace under FG(10% H2, 90% N2) ambient. The photoluminescece (PL) properties of the SiN(x) films with nc-Si were investigated by steady/transient PL spectra measurements by Fluorescence spectrometer with different temperatures. The PL processes could be attributed to the quantum confinement effect of nc-Si and the defects in the film. The PL peak position exhibits a small blue shift with the increasing of the excitation energy, which indicates that the PL portion of the nc-Si increased with smaller size. In addition, the PL lifetime increases and the PL intensity exhibits exponential increase as a result of the decreased temperature which supressed the nonradiative recombination process and then improved the radiative recombination. The PL lifetime of the film significantly reduces with the decreasing of the detection wavelength, which indicates that the PL process related to the the quantum confinement effect strongly depends on temperature. PMID:27400499

  14. 33 CFR 165.T05-0330 - Safety Zone, Shallowbag Bay; Manteo, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone, Shallowbag Bay...-0330 Safety Zone, Shallowbag Bay; Manteo, NC. (a) Definitions. For the purposes of this section, Captain of the Port means the Commander, Sector North Carolina. Representative means any Coast...

  15. Anaerobic Oxidation of Methane Coupled to Nitrite Reduction by Halophilic Marine NC10 Bacteria.

    PubMed

    He, Zhanfei; Geng, Sha; Cai, Chaoyang; Liu, Shuai; Liu, Yan; Pan, Yawei; Lou, Liping; Zheng, Ping; Xu, Xinhua; Hu, Baolan

    2015-08-15

    Anaerobic oxidation of methane (AOM) coupled to nitrite reduction is a novel AOM process that is mediated by denitrifying methanotrophs. To date, enrichments of these denitrifying methanotrophs have been confined to freshwater systems; however, the recent findings of 16S rRNA and pmoA gene sequences in marine sediments suggest a possible occurrence of AOM coupled to nitrite reduction in marine systems. In this research, a marine denitrifying methanotrophic culture was obtained after 20 months of enrichment. Activity testing and quantitative PCR (qPCR) analysis were then conducted and showed that the methane oxidation activity and the number of NC10 bacteria increased correlatively during the enrichment period. 16S rRNA gene sequencing indicated that only bacteria in group A of the NC10 phylum were enriched and responsible for the resulting methane oxidation activity, although a diverse community of NC10 bacteria was harbored in the inoculum. Fluorescence in situ hybridization showed that NC10 bacteria were dominant in the enrichment culture after 20 months. The effect of salinity on the marine denitrifying methanotrophic culture was investigated, and the apparent optimal salinity was 20.5‰, which suggested that halophilic bacterial AOM coupled to nitrite reduction was obtained. Moreover, the apparent substrate affinity coefficients of the halophilic denitrifying methanotrophs were determined to be 9.8 ± 2.2 μM for methane and 8.7 ± 1.5 μM for nitrite. PMID:26048927

  16. SITE CHARACTERIZATION OF A CHROMIUM SOURCE AREA AT THE USCG SUPPORT CENTER, ELIZABETH CITY, NC

    EPA Science Inventory

    The chrome source area is located beneath an old electroplating shop at the United States Coast Guard Support Center near Elizabeth City, NC . This electroplating shop was in
    use for approximately 30 years until 1984 and was the source of discharges of chromic and sulfuric...

  17. ENVIRONMENTAL PUBLIC HEALTH OUTCOMES WORKSHOP PROCEEDINGS -RESEARCH TRIANGLE PARK, NC, 7/30-31/2002

    EPA Science Inventory

    To better define ORD's Environmental Public Health Outcomes (EPHO) research agenda, a workshop was held 7/30-31/2002 at EPA facilities in Research Triangle Park, NC. The intent of this workshop was to engage federal and other organizations in a dialog that will assist ORD in deve...

  18. Colloidal Behavior of Fullerenes (nC60): Role of Coions

    EPA Science Inventory

    Effects of coions on the average initial aggregate size (DH) and zeta potential (ZP) of nC60 in mono and divalent counterion (10 mM) systems were investigated at pH 3, 5.8, and 10. Differences in the effects of SO42-and Cl- could not be established, in presence of Na+, for all pH...

  19. 75 FR 5371 - Environmental Impact Statement: Cumberland, Harnett and Wake Counties, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ... Federal Highway Administration Environmental Impact Statement: Cumberland, Harnett and Wake Counties, NC... issuing this notice to advise the public that an environmental impact statement will be prepared for a... Environmental Impact Statement (EIS) on proposed improvements to the US 401 corridor from north of...

  20. 78 FR 41843 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... 70/ Alfred C. Cunningham Bridge across the Trent River, mile 0.0, at New Bern, NC. The deviation... passage for pedestrians and vehicles during Mumfest. The US 70/Alfred C. Cunningham Bridge across the... C. Cunningham Bridge would open on signal during this timeframe. However, under this...

  1. LAND USE/LAND COVER , NEUSE RIVER WATERSHED, NC (RASTER VERSION)

    EPA Science Inventory

    EOSAT and the North Carolina State University Computer Graphics Center, in cooperation with the NC Center for Geographic Infor- mation and Analysis, developed the Land Use/Land Cover digital data to enhance planning, siting and impact analysis in the Albemarle-Pamlico Estuarine S...

  2. 75 FR 65278 - Pamlico Sound and Adjacent Waters, NC; Danger Zones for Marine Corps Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... of Engineers, Department of the Army 33 CFR Part 334 Pamlico Sound and Adjacent Waters, NC; Danger... its regulations to establish one new danger zone in Pamlico Sound near Marine Corps Air Station Cherry... existing 1.8 mile Danger Zone [as described in Sec. 334.420(b)(1)(i)] in the Pamlico Sound and...

  3. Plasmin releases the anti-tumor peptide from the NC1 domain of collagen XIX.

    PubMed

    Oudart, Jean-Baptiste; Brassart-Pasco, Sylvie; Vautrin, Alexia; Sellier, Christèle; Machado, Carine; Dupont-Deshorgue, Aurelie; Brassart, Bertrand; Baud, S; Dauchez, Manuel; Monboisse, Jean-Claude; Harakat, Dominique; Maquart, François-Xavier; Ramont, Laurent

    2015-02-28

    During tumor invasion, tumor cells degrade the extracellular matrix. Basement membrane degradation is responsible for the production of peptides with anti-tumor properties. Type XIX collagen is associated with basement membranes in vascular, neuronal, mesenchymal and epithelial tissues. Previously, we demonstrated that the non-collagenous NC1, C-terminal, domain of collagen XIX [NC1(XIX)] inhibits the migration capacities of tumor cells and exerts a strong inhibition of tumor growth. Here, we demonstrate that plasmin, one of the most important enzyme involved in tumor invasion, was able to release a fragment of NC1(XIX), which retained the anti-tumor activity. Molecular modeling studies showed that NC1(XIX) and the anti-tumor fragment released by plasmin (F4) adopted locally the same type I β-turn conformation. This suggests that the anti-tumor effect is conformation-dependent. This study demonstrates that collagen XIX is a novel proteolytic substrate for plasmin. Such release may constitute a defense of the organism against tumor invasion. PMID:25668817

  4. Plasmin releases the anti-tumor peptide from the NC1 domain of collagen XIX

    PubMed Central

    Oudart, Jean-Baptiste; Brassart-Pasco, Sylvie; Vautrin, Alexia; Sellier, Christèle; Machado, Carine; Dupont-Deshorgue, Aurelie; Brassart, Bertrand; Baud, S.; Dauchez, Manuel; Monboisse, Jean-Claude; Harakat, Dominique; Maquart, François-Xavier; Ramont, Laurent

    2015-01-01

    During tumor invasion, tumor cells degrade the extracellular matrix. Basement membrane degradation is responsible for the production of peptides with anti-tumor properties. Type XIX collagen is associated with basement membranes in vascular, neuronal, mesenchymal and epithelial tissues. Previously, we demonstrated that the non-collagenous NC1, C-terminal, domain of collagen XIX [NC1(XIX)] inhibits the migration capacities of tumor cells and exerts a strong inhibition of tumor growth. Here, we demonstrate that plasmin, one of the most important enzyme involved in tumor invasion, was able to release a fragment of NC1(XIX), which retained the anti-tumor activity. Molecular modeling studies showed that NC1(XIX) and the anti-tumor fragment released by plasmin (F4) adopted locally the same type I β-turn conformation. This suggests that the anti-tumor effect is conformation-dependent. This study demonstrates that collagen XIX is a novel proteolytic substrate for plasmin. Such release may constitute a defense of the organism against tumor invasion. PMID:25668817

  5. 78 FR 54413 - Proposed Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Star, NC...

  6. 75 FR 49524 - Woodland Mills Corporation, Mill Spring, NC; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Federal Register on July 7, 2010 (75 FR 39049). Workers are engaged in employment related to the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Woodland Mills Corporation, Mill Spring, NC; Notice of...

  7. 75 FR 71463 - Woodland Mills Corporation Mill Spring, NC; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... (75 FR 49524). Workers at the subject firm are engaged in employment related to the production of... Employment and Training Administration Woodland Mills Corporation Mill Spring, NC; Notice of Revised... of Woodland Mills Corporation, Mill Spring, North Carolina, to apply for Trade Adjustment...

  8. 33 CFR 165.T05-1082 - Safety Zone; Atlantic Intracoastal Waterway, Wrightsville Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone; Atlantic Intracoastal Waterway, Wrightsville Beach, NC. 165.T05-1082 Section 165.T05-1082 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS...

  9. 33 CFR 165.T05-0741 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC. 165.T05-0741 Section 165.T05-0741 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS...

  10. Impacts of green space and tree cover on birth outcomes in Durham-Chapel Hill, NC

    EPA Science Inventory

    Ecosystem services affect human health through a variety of mechanisms. We investigated associations between green space and tree cover, and birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births in and around Durham-Chapel Hill, NC, between 1 January 2004 ...

  11. Connecting Green Space, Tree Cover, and Birth Outcomes in Durham-Chapel Hill, NC

    EPA Science Inventory

    Green space provides many ecosystem services relevant to human health. We investigated associations between green space, tree cover, and near-road tree cover with birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births occurring around Durham-Chapel Hill, NC,...

  12. 78 FR 23519 - Safety Zone; Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Federal Register (73 FR 3316). 4. Public Meeting We do not now plan to hold a public meeting. But you may... Beach, NC'' (78 FR 22195, Docket No. USCG-2012-1082). We received no adverse comments on that...

  13. 75 FR 7045 - Key Gas Components, Inc., Marion, NC; Notice of Negative Determination Regarding Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Key Gas Components, Inc., Marion, NC; Notice of Negative Determination Regarding Application for Reconsideration By application dated January 8, 2010, a petitioner requested administrative reconsideration of...

  14. Anaerobic Oxidation of Methane Coupled to Nitrite Reduction by Halophilic Marine NC10 Bacteria

    PubMed Central

    He, Zhanfei; Geng, Sha; Cai, Chaoyang; Liu, Shuai; Liu, Yan; Pan, Yawei; Lou, Liping; Zheng, Ping; Xu, Xinhua

    2015-01-01

    Anaerobic oxidation of methane (AOM) coupled to nitrite reduction is a novel AOM process that is mediated by denitrifying methanotrophs. To date, enrichments of these denitrifying methanotrophs have been confined to freshwater systems; however, the recent findings of 16S rRNA and pmoA gene sequences in marine sediments suggest a possible occurrence of AOM coupled to nitrite reduction in marine systems. In this research, a marine denitrifying methanotrophic culture was obtained after 20 months of enrichment. Activity testing and quantitative PCR (qPCR) analysis were then conducted and showed that the methane oxidation activity and the number of NC10 bacteria increased correlatively during the enrichment period. 16S rRNA gene sequencing indicated that only bacteria in group A of the NC10 phylum were enriched and responsible for the resulting methane oxidation activity, although a diverse community of NC10 bacteria was harbored in the inoculum. Fluorescence in situ hybridization showed that NC10 bacteria were dominant in the enrichment culture after 20 months. The effect of salinity on the marine denitrifying methanotrophic culture was investigated, and the apparent optimal salinity was 20.5‰, which suggested that halophilic bacterial AOM coupled to nitrite reduction was obtained. Moreover, the apparent substrate affinity coefficients of the halophilic denitrifying methanotrophs were determined to be 9.8 ± 2.2 μM for methane and 8.7 ± 1.5 μM for nitrite. PMID:26048927

  15. 78 FR 2650 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ...; Wrightsville Beach, NC'' (77 FR 41911, docket number USCG-2012-0368). C. Basis and Purpose North Carolina... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed..., 2008, issue of the Federal Register (73 FR 3316). 4. Public Meeting We do not now plan to hold a...

  16. 77 FR 35321 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Public Participation and Request for... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). 4. Public..., Wrightsville Channel; Wrightsville Beach, NC ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast...

  17. 78 FR 19155 - Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Channel; Wrightsville Beach, NC'' in the Federal Register (77 FR 35321). We received no comments on that...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed..., 2008, issue of the Federal Register (73 FR 3316). 4. Public Meeting We do not now plan to hold a...

  18. Shape and secondary structure prediction for ncRNAs including pseudoknots based on linear SVM

    PubMed Central

    2013-01-01

    Background Accurate secondary structure prediction provides important information to undefirstafinding the tertiary structures and thus the functions of ncRNAs. However, the accuracy of the native structure derivation of ncRNAs is still not satisfactory, especially on sequences containing pseudoknots. It is recently shown that using the abstract shapes, which retain adjacency and nesting of structural features but disregard the length details of helix and loop regions, can improve the performance of structure prediction. In this work, we use SVM-based feature selection to derive the consensus abstract shape of homologous ncRNAs and apply the predicted shape to structure prediction including pseudoknots. Results Our approach was applied to predict shapes and secondary structures on hundreds of ncRNA data sets with and without psuedoknots. The experimental results show that we can achieve 18% higher accuracy in shape prediction than the state-of-the-art consensus shape prediction tools. Using predicted shapes in structure prediction allows us to achieve approximate 29% higher sensitivity and 10% higher positive predictive value than other pseudoknot prediction tools. Conclusions Extensive analysis of RNA properties based on SVM allows us to identify important properties of sequences and structures related to their shapes. The combination of mass data analysis and SVM-based feature selection makes our approach a promising method for shape and structure prediction. The implemented tools, Knot Shape and Knot Structure are open source software and can be downloaded at: http://www.cse.msu.edu/~achawana/KnotShape. PMID:23369147

  19. 75 FR 15741 - Hickory Dyeing and Winding Co., Inc.: Hickory, NC; Notice of Termination of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Hickory Dyeing and Winding Co., Inc.: Hickory, NC; Notice of... workers of Hickory Dyeing and Winding Co., Inc., Hickory, North Carolina. The petitioner has...

  20. Numerical study of self modulation instability of 1 nC electron bunch at ATF

    SciTech Connect

    Fang Yun; Mori, Warren; Muggli, Patric

    2012-12-21

    The development of self-modulation instability (SMI) is investigated numerically for the 1 nC electron bunch available at Accelerator Test Facility (ATF) of Brookhaven National Laboratory (BNL). Possible experiment based on the simulation results is proposed. All the simulations are performed with the 2D-cylindrically symmetric particle-in-cell code.

  1. Cranberry magnetite deposits Avery County, N.C., and Carter County, Tenn.

    USGS Publications Warehouse

    Kline, M.H.; Ballard, T.J.

    1948-01-01

    The Cranberry magnetite deposits occur in pre-Cambrian granite-gneiss in a belt extending from 3 miles southeast of Cranberry, N.C., to about 6 miles southwest of Magnetic City, Tenn. The belt forms a curve, elongated to the north, approximately 26 miles in length.

  2. UV Irradiation and Humic Acid Mediate Aggregation of Aqueous Fullerene (nC60) Nanoparticles

    EPA Science Inventory

    The transport and fate of engineered nanomaterials is affected by multiple environmental factors, including sunlight and natural organic matter. In this study, the initial aggregation kinetics of aqueous fullerene (nC60) nanoparticles before and after UVA irradiation was investig...

  3. 78 FR 79726 - Norfolk Southern Railway Company-Abandonment Exemption-in Gaston County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Gaston County, NC Norfolk Southern Railway Company (NSR) has filed a verified notice of exemption under 49 CFR part 1152 subpart F-Exempt Abandonments...

  4. 77 FR 34215 - Special Local Regulations for Marine Events, Swim Event; Lake Gaston, Littleton, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ..., Swim Event, Lake Gaston; Littleton, NC'' in the Federal Register (77 FR 19954). We received no comments... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events, Swim...

  5. Persistent photoconductivity studies in a-Si:H/nc-Si:H thin film superlattices

    NASA Astrophysics Data System (ADS)

    Yadav, Asha; Agarwal, Pratima

    2015-09-01

    The electronic properties of undoped a-Si:H/nc-Si:H superlattice structures have been investigated by photoconductivity measurements. Multilayer structures having alternate layers of a-Si:H and nc-Si:H were deposited on corning 1737 glass substrate by Hot wire chemical vapor deposition technique, keeping the total thickness of films constant at 700 nm. Dark and photo conductivity along with persistent photoconductivity (PPC) are measured in coplanar geometry using Ag paste as electrodes. Quite interestingly room temperature PPC has been observed in these undoped a-Si:H/nc-Si:H superlattice structures. PPC decay time constant, its dependence on exposure time, electric field, number of periods and annealing temperature have been studied in detail. The origin of PPC is understood in terms of competition between carriers transport in the lateral direction due to external field and along the depth due to band bending at a-Si:H/nc-Si:H interfaces. Carriers trapped in the interfaces states or the separation of carriers due to band bending are likely to be responsible for observed PPC.

  6. Fabrication and Characteristics of an nc-Si/c-Si Heterojunction MOSFETs Pressure Sensor

    PubMed Central

    Zhao, Xiaofeng; Wen, Dianzhong; Li, Gang

    2012-01-01

    A novel nc-Si/c-Si heterojunction MOSFETs pressure sensor is proposed in this paper, with four p-MOSFETs with nc-Si/c-Si heterojunction as source and drain. The four p-MOSFETs are designed and fabricated on a square silicon membrane by CMOS process and MEMS technology where channel resistances of the four nc-Si/c-Si heterojunction MOSFETs form a Wheatstone bridge. When the additional pressure is P, the nc-Si/c-Si heterojunction MOSFETs pressure sensor can measure this additional pressure P. The experimental results show that when the supply voltage is 3 V, length-width (L:W) ratio is 2:1, and the silicon membrane thickness is 75 μm, the full scale output voltage of the pressure sensor is 15.50 mV at room temperature, and pressure sensitivity is 0.097 mV/kPa. When the supply voltage and L:W ratio are the same as the above, and the silicon membrane thickness is 45 μm, the full scale output voltage is 43.05 mV, and pressure sensitivity is 2.153 mV/kPa. Therefore, the sensor has higher sensitivity and good temperature characteristics compared to the traditional piezoresistive pressure sensor. PMID:22778646

  7. 75 FR 67214 - Special Local Regulations for Marine Events; Wrightsville Channel, Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... Beach, NC in the Federal Register (75 FR 56024). We received no comments on the proposed rule. No public... Battleship Full and Half Iron Distance Triathlon,'' to be held on the waters adjacent to Wrightsville Beach... 13, 2010, the Wilmington YMCA will sponsor the ``Beach 2 Battleship Full and Half Iron...

  8. 76 FR 30830 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), at Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... Northeast Cape Fear River, at Wilmington, NC in the Federal Register (76 FR 8663). We received no comments... Battleship North Carolina Half Marathon and 5K. DATES: This rule is effective June 27, 2011. ADDRESSES... Battleship North Carolina Half Marathon & 5K is another annual event that occurs in the Wrightsville...

  9. 33 CFR 80.515 - Cape Henry, VA to Cape Hatteras, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Henry, VA to Cape Hatteras, NC. 80.515 Section 80.515 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.515 Cape Henry, VA...

  10. 77 FR 12475 - Drawbridge Operation Regulations; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ...The Commander, Fifth Coast Guard District, has issued a temporary deviation from the regulations governing the operation of the Cape Fear Memorial Bridge, across the Cape Fear River, mile 26.8, at Wilmington, NC. The deviation restricts the operation of the draw span to facilitate the structural repairs and painting of the...

  11. More Metal Cyanide Species: Detection of AlNC (X 1Σ+) toward IRC +10216

    NASA Astrophysics Data System (ADS)

    Ziurys, L. M.; Savage, C.; Highberger, J. L.; Apponi, A. J.; Guélin, M.; Cernicharo, J.

    2002-01-01

    A new metal-containing species, AlNC, has been detected toward the circumstellar envelope of the late-type carbon star IRC +10216, using the IRAM 30 m telescope. The J=11-->10, 12-->11, and 13-->12 rotational transitions at 2 mm and the J=18-->17 and J=21-->20 transitions at 1.2 mm of this linear, closed-shell molecule were observed in this object. The line profiles appear U-shaped, indicating a source >~20", and the horn-to-center ratios suggest a shell-like distribution. In contrast, the other two Al-bearing molecules previously detected, AlF and AlCl, exist exclusively near the stellar photosphere. Modeling of the detected transitions, assuming a spherical-shell distribution, indicates a column density of Ntot~9×1011 cm-2 and a fractional abundance relative to H2 of ~3×10-10 for AlNC. A rotational temperature of Trot~60 K was also derived for this molecule, suggesting that shock waves may be synthesizing AlNC in the outer envelope. This species is the fourth metal cyanide/isocyanide compound discovered in this object, along with MgNC, MgCN, and NaCN. These data suggest that cyanide/isocyanide species are the major molecular carriers of metals in circumstellar gas.

  12. The NC16A Domain of Collagen XVII Plays a Role in Triple Helix Assembly and Stability*

    PubMed Central

    Van den Bergh, Françoise; Fu, Chang-Ling; Olague-Marchan, Monica; Giudice, George J.

    2007-01-01

    Collagen XVII/BP180 is a transmembrane constituent of the epidermal anchoring complex. To study the role of its non-collagenous linker domain, NC16A, in protein assembly and stability, we analyzed the following recombinant proteins: the collagen XVII extracellular domain with or without NC16A, and a pair of truncated proteins comprising the COL15-NC15 stretch expressed with or without NC16A. All four proteins were found to exist as stable collagen triple helices; however, the two missing NC16A exhibited melting temperatures significantly lower than their NC16A-containing counterparts. Protein refolding experiments revealed that the rate of triple helix assembly of the collagen model peptide GPP10 is greatly increased by the addition of an upstream NC16A domain. In summary, the NC16A linker domain of collagen XVII exhibits a positive effect on both the rate of assembly and the stability of the adjoining collagen structure. PMID:17045967

  13. 77 FR 66072 - Designation of New Grantee; Foreign Trade Zone 66, Wilmington, NC, and Foreign-Trade Zone 67...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-01

    ... Foreign-Trade Zones Board Designation of New Grantee; Foreign Trade Zone 66, Wilmington, NC, and Foreign-Trade Zone 67, Morehead City, NC Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), and the Foreign-Trade Zones Board Regulations (15 CFR part...

  14. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey Point..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and...

  15. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey Point..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and...

  16. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey Point..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and...

  17. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey Point..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and...

  18. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey Point..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and...

  19. 33 CFR 100.35T05-0482 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Marine Events, Wrightsville Channel; Wrightsville Beach, NC. 100.35T05-0482 Section 100.35T05-0482..., Wrightsville Channel; Wrightsville Beach, NC. (a) Regulated area. The following location is a regulated area... Bascule Bridge, mile 283.1, latitude 34°13′06″ North, longitude 077°48′44″ West, at Wrightsville...

  20. 33 CFR 100.35T05-0482 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Marine Events, Wrightsville Channel; Wrightsville Beach, NC. 100.35T05-0482 Section 100.35T05-0482..., Wrightsville Channel; Wrightsville Beach, NC. (a) Regulated area. The following location is a regulated area... Bascule Bridge, mile 283.1, latitude 34°13′06″ North, longitude 077°48′44″ West, at Wrightsville...

  1. Sulphur and oxygen sequestration of n-C37 and n-C38 unsaturated ketones in an immature kerogen and the release of their carbon skeletons during early stages of thermal maturation

    USGS Publications Warehouse

    Koopmans, M.P.; Schaeffer-Reiss, C.; De Leeuw, J. W.; Lewan, M.D.; Maxwell, J.R.; Schaeffer, P.; Sinninghe, Damste J.S.

    1997-01-01

    Sedimentary rock from the Gessoso-solfifera Formation (Messinian) in the Vena del Gesso Basin (northern Italy) containing immature (Ro = 0.25%) S-rich organic matter was artificially matured by hydrous pyrolysis at temperatures from 160 to 330??C for 72 h to study the diagenetic fate of n-C37 and n-C38 di-and tri-unsaturated methyl and ethyl ketones (alkenones) biosynthesised by several prymnesiophyte algae. During early diagenesis, the alkenones are incorporated into the kerogen by both sulphur and oxygen cross-linking as indicated by chemical degradation experiments with the kerogen of the unheated sample. Heating at temperatures between 160 and 260??C, which still represents early stages of thermal maturation, produces large amounts (up to 1 mg/g TOC) of S-bound, O-bound, and both S-and O-bound n-C37 and n-C38 skeletons, saturated n-C37 and n-C38 methyl, ethyl, and mid-chain ketones, C37 and C38 mid-chain 2,5-di-n-alkylthiophenes, C37 and C38 1,2-di-n-alkylbenzenes, and C37 and C38 n-alkanes. With increasing thermal maturation, three forms of the n-C37 and n-C38 skeletons are relatively stable (saturated hydrocarbons, 1,2-di-n-alkylbenzenes and saturated ketones), whereas the S-and O-bound skeletons are relatively labile. These results suggest that in natural situations saturated ketones with an n-C37 and n-C38 skeleton can be expected as well as the corresponding hydrocarbons. Copyright ?? 1997 Elsevier Science Ltd.

  2. Comparison of community structures of Candidatus Methylomirabilis oxyfera-like bacteria of NC10 phylum in different freshwater habitats.

    PubMed

    Shen, Li-Dong; Wu, Hong-Sheng; Gao, Zhi-Qiu; Liu, Xu; Li, Ji

    2016-01-01

    Methane oxidation coupled to nitrite reduction is mediated by 'Candidatus Methylomirabilis oxyfera' (M. oxyfera), which belongs to the NC10 phylum. In this study, the community composition and diversity of M. oxyfera-like bacteria of NC10 phylum were examined and compared in four different freshwater habitats, including reservoir sediments (RS), pond sediments (PS), wetland sediments (WS) and paddy soils (PAS), by using Illumina-based 16S rRNA gene sequencing. The recovered NC10-related sequences accounted for 0.4-2.5% of the 16S rRNA pool in the examined habitats, and the highest percentage was found in WS. The diversity of NC10 bacteria were the highest in RS, medium in WS, and lowest in PS and PAS. The observed number of OTUs (operational taxonomic unit; at 3% cut-off) were 97, 46, 61 and 40, respectively, in RS, PS, WS and PAS. A heterogeneous distribution of NC10 bacterial communities was observed in the examined habitats, though group B members were the dominant bacteria in each habitat. The copy numbers of NC10 bacterial 16S rRNA genes ranged between 5.8 × 10(6) and 3.2 × 10(7) copies g(-1) sediment/soil in the examined habitats. These results are helpful for a systematic understanding of NC10 bacterial communities in different types of freshwater habitats. PMID:27157928

  3. Comparison of community structures of Candidatus Methylomirabilis oxyfera-like bacteria of NC10 phylum in different freshwater habitats

    PubMed Central

    Shen, Li-dong; Wu, Hong-sheng; Gao, Zhi-qiu; Liu, Xu; Li, Ji

    2016-01-01

    Methane oxidation coupled to nitrite reduction is mediated by ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera), which belongs to the NC10 phylum. In this study, the community composition and diversity of M. oxyfera-like bacteria of NC10 phylum were examined and compared in four different freshwater habitats, including reservoir sediments (RS), pond sediments (PS), wetland sediments (WS) and paddy soils (PAS), by using Illumina-based 16S rRNA gene sequencing. The recovered NC10-related sequences accounted for 0.4–2.5% of the 16S rRNA pool in the examined habitats, and the highest percentage was found in WS. The diversity of NC10 bacteria were the highest in RS, medium in WS, and lowest in PS and PAS. The observed number of OTUs (operational taxonomic unit; at 3% cut-off) were 97, 46, 61 and 40, respectively, in RS, PS, WS and PAS. A heterogeneous distribution of NC10 bacterial communities was observed in the examined habitats, though group B members were the dominant bacteria in each habitat. The copy numbers of NC10 bacterial 16S rRNA genes ranged between 5.8 × 106 and 3.2 × 107 copies g−1 sediment/soil in the examined habitats. These results are helpful for a systematic understanding of NC10 bacterial communities in different types of freshwater habitats. PMID:27157928

  4. Light shift from ultraviolet to near infrared light: Cerenkov luminescence with gold nanocluster - near infrared (AuNc-NIR) conjugates

    NASA Astrophysics Data System (ADS)

    Yoo, Su Woong; Mun, Hyoyoung; Oh, Gyungseok; Ryu, Youngjae; Kim, Min-Gon; Chung, Euiheon

    2015-03-01

    Cerenkov luminescence (CL) is generated when a charged particle moves faster than the speed of light in dielectric media. Recently CL imaging becomes an emerging technique with the use of radioisotopes. However, due to relatively weak blue light production and massive tissue attenuation, CL has not been applied widely. Therefore, we attempted to shift the CL emission to more near infrared (NIR) spectrum for better tissue penetration by using Cerenkov Radiation Energy Transfer (CRET). Gold nanoclusters were conjugated with NIR dye molecules (AuNc-IR820 and AuNc-ICG) to be activated with ultraviolet light. We found optimal conjugate concentrations of AuNc-NIR conjugates by spectroscopy system to generate maximal photon emission. When exposed by ultraviolet light, the emission of NIR light from the conjugates were verified. In quantitative analysis, AuNc-NIR conjugates emit brighter light signal than pure AuNc. This result implies that NIR fluorescent dyes (both IR820 and ICG) can be excited by the emission from AuNc. Following the above baseline experiment, we mixed F-18 fluorodeoxyglucose (F-18 FDG) radioisotope to the AuNc- NIR conjugates, to confirm NIR emission induced from Cerenkov radiation. Long pass filter was used to block Cerenkov luminescence and to collect the emission from AuNc-NIR conjugates. Instead of one long exposure imaging with CCD, we used multiple frame scheme to eliminate gamma radiation strike in each frame prior to combination. In summary, we obtained NIR emission light from AuNc-NIR conjugated dyes that is induced from CL. We plan to perform in vivo small animal imaging with these conjugates to assess better tissue penetration.

  5. Agency, communion and entitlement.

    PubMed

    Żemojtel-Piotrowska, Magdalena A; Piotrowski, Jarosław P; Clinton, Amanda

    2016-06-01

    In this study, the relationship between agency, communion, and the active, passive, and revenge forms of entitlement is examined. Results indicate that active entitlement was positively related to agency, negatively to communion (Study 1), and unrelated to unmitigated agency and communion (Study 2). Passive entitlement was positively related to communion (in regular and unmitigated forms) and negatively related to agency (in both forms). Revenge entitlement was positively related to agency (unmitigated and regular), and negatively related to both regular and unmitigated communal orientations. Detected relationships were independent from self-esteem (Study 1). The findings are discussed in relation to distinctions between narcissistic and healthy entitlement, and within the context of the three-dimensional model of entitlement. PMID:25594535

  6. Standing Wave Ground State in High Density, Zero Temperature QCD at Large NC

    NASA Astrophysics Data System (ADS)

    Deryagin, D. V.; Grigoriev, D. Yu.; Rubakov, V. A.

    Chiral symmetry breaking in QCD at zero temperature and high fermionic density is studied in the limit NC → ∞. We evaluate the effective action in the ladder approximation and integrate out fermions by introducing the bilocal field Σ(x, y), which enters the action as the mass operator for fermions. It is argued that at large fermionic chemical potential the mass operator Σ(x, y) has a small but nonvanishing expectation value. The condensate of the field Σ(x, y) and the fermionic condensate < bar ψ (x) ψ (y)> are inhomogeneous and anisotropic, so that the ground state has the structure of the standing wave with respect to these order parameters. Unlike possible color superconductivity, this symmetry breaking occurs to the leading order in 1/NC.

  7. Analysis of 56-plet Positive Parity Baryon Decays in the 1/Nc Expansion

    SciTech Connect

    Jose Goity, Norberto Scoccola, Chandana Jayalath

    2009-10-01

    The partial decay widths of positive parity baryons belonging to 56-plets of SU(6) are analyzed in the framework of the 1/Nc expansion. The channels considered are those with emission of a single pion, K or K-bar mesons, and the analysis is carried out to subleading order in 1/Nc and to first order in SU(3) symmetry breaking. The results for the multiplet [56,0+], to which the Roper resonance belongs, indicate a poor description at leading order, requiring large next to leading order corrections. For the multiplet [56,2+], the P-wave decays in the non-strange sector are well described at leading order and important SU(3) breaking corrections are necessary to describe transitions involving strangeness, on the other hand, the F-wave decays require the next to leading order corrections, which turn out to be however of natural magnitude.

  8. Automated generation of NC part programs for excimer laser ablation micromachining from known 3D surfaces

    NASA Astrophysics Data System (ADS)

    Mutapcic, Emir; Iovenitti, Pio G.; Hayes, Jason P.

    2002-11-01

    The purpose of this research project is to improve the capability of the laser micromachinning process, so that any desired 3D surface can be produced by taking the 3D information from a CAD system and automatically generating the NC part programs. In addition, surface quality should be able to be controlled by specifying optimised parameters. This paper presents the algorithms and a software system, which processes 3D geometry in an STL file format from a CAD system and produces the NC part program to mill the surface using the Excimer laser ablation process. Simple structures are used to demonstrate the prototype system's part programming capabilities, and an actual surface is machined.

  9. Integrated CAD/CAM/CNC system based on STEP-NC and intelligent manufacturing

    NASA Astrophysics Data System (ADS)

    Du, Juan; Tian, Xitian; Zhang, Zhenming; Xu, Jianxin; Zhu, Mingquan

    2005-12-01

    In order to realize bi-direction exchange of information and knowledge sharing between CAD/CAM systems and CNC machines, a method of information integration was proposed based on process data model and STEP-NC neutral file. A frame of integrated CAD/CAM/CNC systems was established, and the key integration techniques including process data modeling based on XML form and automatic feature recognition were studied. Since the STEP-NC based CNC (STEP- CNC) system can undertake various intelligent functions that cannot be performed by the conventional CNC based on ISO 6983, the intelligent manufacturing functions of STEP- CNC system was also discussed. The presented methodology combining with the modern net and communication technologies provides an effective means for developing intelligent, integrated manufacturing systems for the 21 century.

  10. Microscopic ESR study of N@C60 using a Magnetic Resonance Force Microscope

    NASA Astrophysics Data System (ADS)

    Banerjee, P.; Pelekhov, D. V.; Fong, K. C.; Lee, I. H.; Hammel, P. C.; Harneit, W.

    2007-03-01

    We report electron spin resonance studies of the endohedral fullerene N@C60 using the novel technique of magnetic resonance force microscopy (MRFM). These studies are performed at temperatures down to 1 K on both thin films of N@C60 and in samples where the endohedral fullerene is incorporated into a bulk crystalline matrix. Utilizing the large magnetic field gradients (˜ 10^5 Tesla/meter) in the vicinity of our micromagnetic probe tip, we are able to selectively probe the electron spins in sub--micron volumes. Further, our schemes for spin manipulation allow us to measure the spin--lattice relaxation rate (T1-1) with a spatial resolution in one dimension of approximately 20 nanometers. We will also discuss our efforts to improve the sensitivity of our microscope for detecting individual electronic spins. B. Naydenov, C. Spudat, W. Harneit, H. I. Suss, J. Hullinger, J. Nuss, M. Jansen, Chem. Phys. Lett., 424, 327 (2006).

  11. The metallofullerene field-induced single-ion magnet HoSc2 N@C80.

    PubMed

    Dreiser, Jan; Westerström, Rasmus; Zhang, Yang; Popov, Alexey A; Dunsch, Lothar; Krämer, Karl; Liu, Shi-Xia; Decurtins, Silvio; Greber, Thomas

    2014-10-13

    The low-temperature magnetic properties of the endohedral metallofullerene HoSc2 N@C80 have been studied by superconducting quantum interference device (SQUID) magnetometry. Alternating current (ac) susceptibility measurements reveal that this molecule exhibits slow relaxation of magnetization in a small applied field with timescales in the order of milliseconds. The equilibrium magnetic properties of HoSc2 N@C80 indicate strong magnetic anisotropy. The large differences in magnetization relaxation times between the present compound and the previously investigated DySc2 N@C80 are discussed. PMID:25164532

  12. Service manual for the computer based temperature control system for the NC shop

    SciTech Connect

    Hansen, H.; Carpenter, E.

    1986-01-27

    This manual is intended to serve as a guide to the persons responsible for the maintenance of the computer-based temperature control system in the NC shop. It provides a description of the functions of the system, its components and gives general methods for troubleshooting common problems which sometimes arise during the operation of the system. The manual covers both electronic/software topics as well as HVAC/mechanical topics, since the system uses components from both domains.

  13. Mixed enrichment core design for the NC State University PULSTAR Reactor

    SciTech Connect

    Mayo, C.W.; Verghese, K.; Huo, Y.G.

    1997-12-01

    The North Carolina State University PULSTAR Reactor license was renewed for an additional 20 years of operation on April 30, 1997. The relicensing period added additional years to the facility operating time through the end of the second license period, increasing the excess reactivity needs as projected in 1988. In 1995, the Nuclear Reactor Program developed a strategic plan that addressed the future maintenance, development, and utilization of the facility. Goals resulting from this plan included increased academic utilization of the facility in accordance with its role as a university research facility, and increased industrial service use in accordance with the mission of a land grant university. The strategic plan was accepted, and it is the intent of the College of Engineering to operate the PULSTAR Reactor as a going concern through at least the end of the current license period. In order to reach the next relicensing review without prejudice due to low excess reactivity, it is desired to maintain sufficient excess reactivity so that, if relicensed again, the facility could continue to operate without affecting users until new fuel assistance was provided. During the NC State University license renewal, the operation of the PULSTAR Reactor at the State University of New York at Buffalo (SUNY Buffalo) was terminated. At that time, the SUNY Buffalo facility had about 240 unused PULSTAR Reactor fuel pins with 6% enrichment. The objective of the work reported here was to develop a mixed enrichment core design for the NC State University PULSTAR reactor which would: (1) demonstrate that 6% enriched SUNY buffalo fuel could be used in the NC State University PULSTAR Reactor within the existing technical specification safety limits for core physics parameters; (2) show that use of this fuel could permit operating the NC State University PULSTAR Reactor to 2017 with increased utilization; and (3) assure that the decision whether or not to relicense the facility would

  14. Thread milling on N/C and CNC milling machines. Final report

    SciTech Connect

    Ashbaugh, F.A.; Murry, K.R.

    1985-12-01

    A unique thread-cutting tool design has been developed which permits threading of internal or external features; right- or left-hand threads; and standard, metric, or special pitches within a given size range without changing tools. One of the major advantages of the technique is the ability to produce small threads on N/C and CNC milling manchines. This study presents results showing fabrication of quality threads as small as number 0-80 in selected materials.

  15. O (p6) extension of the large-NC partial wave dispersion relations

    NASA Astrophysics Data System (ADS)

    Guo, Z. H.; Sanz-Cillero, J. J.; Zheng, H. Q.

    2008-04-01

    Continuing our previous work [Z.H. Guo, J.J. Sanz-Cillero, H.Q. Zheng, JHEP 0706 (2007) 030], large-NC techniques and partial wave dispersion relations are used to discuss ππ scattering amplitudes. We get a set of predictions for O (p6) low-energy chiral perturbation theory couplings. They are provided in terms of the masses and decay widths of scalar and vector mesons.

  16. 5. (Credit LSU) The NcNeil Street Station from Douglas Island, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. (Credit LSU) The NcNeil Street Station from Douglas Island, across Cross Bayou, c1907. Note the enlarged wood-framed filter wing on the left; the coal shed on the right; and the low service auxiliary pump house on tracks on the incline on the bank leading down to Cross Bayou. From: Louisiana State University, Shreveport Archives post card collection) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

  17. Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus.

    PubMed Central

    Schatz, G; Pichova, I; Vogt, V M

    1997-01-01

    In retroviruses, the viral protease (PR) is released as a mature protein by cleavage of Gag, Gag-Pro, or Gag-Pro-Pol precursor polypeptides. In avian sarcoma and leukemia viruses (ASLV), PR forms the C-terminal domain of Gag. Based on the properties of a mutation (cs22) in the cleavage site between the upstream NC domain and the PR domain, the proteolytic liberation of PR previously was inferred to be essential for processing of Gag and Pol proteins. To study this process in more detail, we have analyzed the effects that several mutations at the NC-PR cleavage site have on proteolytic processing in virus-like particles expressed in COS and quail cells. Mutant Gag proteins carrying the same mutations also were synthesized in vitro and tested for processing with purified PR. In both types of studies, N-terminal sequencing of the liberated PR domain was carried out to exactly identify the site of cleavage. Finally, synthetic peptides corresponding to the mutant proteins were assessed for the ability to act as substrates for PR. The results were all consistent and led to the following conclusions. (i) In vivo, if normal processing between NC and PR is prevented by mutations, limited cleavage occurs at a previously unrecognized alternative site three amino acids downstream, i.e., in PR. This N-terminally truncated PR is inactive as an enzyme, as inferred from the global processing defect in cs22 and a similar mutant. (ii) In Gag proteins translated in vitro, purified PR cleaves this alternative site as rapidly as it does the wild-type site. (iii) Contrary to previously accepted rules describing retroviral cleavage sites, an isoleucine residue placed at the P1 position of the NC-PR cleavage site does not hinder normal processing. (iv) A proline residue placed at the P2 position in this cleavage site blocks normal processing. PMID:8985369

  18. The QCD Phase Diagram: Large Nc, Quarkyonic Matter and the Triple Point

    SciTech Connect

    McLerran L.

    2010-01-31

    I discuss the phase diagram of QCD in the large N_c limit. Quarkyonic Matter is described. The properties of QCD matter as measured in the abundance of produced particles are shown to be consistent with this phase diagram. A possible triple point of Hadronic Mater, Deconfined Matter and Quarkyonic matter is shown to explain various behaviors of ratios of particles abundances seen in CERN fixed target experiments.

  19. Preparation and photoluminescence of nc-Si/SiO2 MQW

    NASA Astrophysics Data System (ADS)

    Cheng, Buwen; Yu, Jinzhong; Yu, Zhuo; Lei, Zhenlin; Li, Daizong; Wang, Qiming

    1998-08-01

    The deposition rate and refractive index for a-Si(amorphous silicon) and SiO2 grown by PECVD were studied under different pressure, power and proportion of reactant source gases. a-Si/SiO2 MQW(multi-quantum well) with high quality was deposited under suitable conditions, in which the thickness of the a-Si layers is several nanometers. The sample of a-Si/SiO2 MQW was crystallized by laser annealing. Because of the confinement of the SiO2 layers, crystalline grains were formed during the a-Si layers were being crystallized. The size of the crystalline grains were not more than the thickness of the a-Si layers. The a-Si layers were crystallized to be nanometer crystalline silicon (nc-Si), therefore, nc-Si/SiO2 MQW was formed. For the a-Si/SiO2 MQW with 4.0 nm a-Si wells separated by 5 nm SiO2 barriers, most of the a-Si were crystallized to silicon grains after laser annealing, and the size of the grains is 3.8 nm. Strong photoluminescence with three peaks from the nc-Si/SiO2 MQW was detected at 10 K. The wavelength of the peaks were 810 nm, 825 nm and 845 nm, respectively.

  20. Thermal Evolution of Defects and Hydrogenated Surfaces in nc-Si:H

    NASA Astrophysics Data System (ADS)

    Kiriluk, Kristin; Williamson, Don; Bobela, David; Madan, Arun; Zhu, Feng; Taylor, P. Craig

    2011-03-01

    Photovoltaics research has created a push for new materials and nanotechnology is a primary focus. The most familiar of the nanomaterials is hydrogenated nanocrystalline silicon (nc-Si:H). nc-Si:H has less light-induced degradation than a-Si:H and is cheaper to make than crystalline silicon. X-ray diffraction (XRD), small angle X-ray scattering (SAXS), and electron spin resonance (ESR) experiments explored the crystallite size, orientation and defect density on nc-Si:H samples with varying crystalline volume fraction (CVF). Samples with CVF ~ 50 % show preferential [220] crystallite orientation, whose microstructure changes with thermal annealing. Modeling of SAXS data for as-grown material shows that the crystallite surfaces are 20% to 40% hydrogenated. After high temperature annealing, hydrogen leaves these surfaces and the ESR signal increases by about 10 times. We discuss these results and then speculate on the relationship between hydrogen, defects, and microstructure. This work has been supported by the NSF under grants DMR-0702351, and by the NSF REMRSEC under grant DMR-08-20518.

  1. Concentration of mutations causing Schmid metaphyseal chondrodysplasia in the NC1 domain of type X collagen

    SciTech Connect

    McIntosh, I.; Abbott, M.H.; Francomano, C.A.

    1994-09-01

    Schmid metaphyseal chondrodysplasia (SMCD, MIM 156500) is an autosomal dominant disorder of the osseous skeleton resulting in short stature, coxa vara and a waddling gait. Type X collagen is an extracellular matrix protein expressed exclusively by hypertrophic chondrocytes. We have previously identified four mutations in the type X collagen gene (COL10A1) in patients with SMCD. Each of these mutations, as well as another three reported by other investigators, are in the carboxy-terminal non-collagenous domain (NC1). Here, we present data for another three mutations each predicted to cause premature termination of translation within the NC1 domain. Two are nonsense mutations, Y628X and W651X, while the third is a frameshift resulting from the deletion of two nucleotides, 1856delCC. Each of these mutations occurred de novo, resulting in sporadic cases of SMCD. Four frameshift mutations have now been reported to initiate within 10bp of each other in the NC1 domain, namely 1865delC, 1856delCC, 1856del13 and 1866del10. These findings further support the hypothesis that SMCD is the result of the mutant type X collagen molecule being unable to participate in trimerization, although a dominant-negative model of disease pathogenesis has not been formally excluded.

  2. Bayesian reliability modeling and assessment solution for NC machine tools under small-sample data

    NASA Astrophysics Data System (ADS)

    Yang, Zhaojun; Kan, Yingnan; Chen, Fei; Xu, Binbin; Chen, Chuanhai; Yang, Chuangui

    2015-11-01

    Although Markov chain Monte Carlo(MCMC) algorithms are accurate, many factors may cause instability when they are utilized in reliability analysis; such instability makes these algorithms unsuitable for widespread engineering applications. Thus, a reliability modeling and assessment solution aimed at small-sample data of numerical control(NC) machine tools is proposed on the basis of Bayes theories. An expert-judgment process of fusing multi-source prior information is developed to obtain the Weibull parameters' prior distributions and reduce the subjective bias of usual expert-judgment methods. The grid approximation method is applied to two-parameter Weibull distribution to derive the formulas for the parameters' posterior distributions and solve the calculation difficulty of high-dimensional integration. The method is then applied to the real data of a type of NC machine tool to implement a reliability assessment and obtain the mean time between failures(MTBF). The relative error of the proposed method is 5.8020×10-4 compared with the MTBF obtained by the MCMC algorithm. This result indicates that the proposed method is as accurate as MCMC. The newly developed solution for reliability modeling and assessment of NC machine tools under small-sample data is easy, practical, and highly suitable for widespread application in the engineering field; in addition, the solution does not reduce accuracy.

  3. 20 CFR 439.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Federal agency or agency. 439.645 Section 439.645 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 439.645 Federal agency or agency. Federal agency or...

  4. INDOOR/OUTDOOR PARTICLE SIZE DISTRIBUTIONS MEASURED IN SELECT HOMES IN THE RALEIGH-DURHAM-CHAPEL HILL, NC AREA

    EPA Science Inventory

    Particle size distributions were measured indoors and outdoors of six residences in the Raleigh-Durham-Chapel Hill, NC area to characterize the factors affecting particle concentrations in the indoor environment, including infiltration of outdoor aerosols. Size resolved partic...

  5. 78 FR 13857 - Foreign-Trade Zone 93-Raleigh-Durham, NC; Authorization of Production Activity; Revlon Consumer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... (77 FR 65856-65857, 10/31/12). The FTZ Board has determined that no further review of the activity is...; Revlon Consumer Products Corporation (Hair Coloring Products); Oxford, NC On October 10, 2012,...

  6. Poplar breeding and testing strategies in the NC US: Demonstration of potential yield and consideration of future research needs.

    SciTech Connect

    Riemenschneider, Don; Berguson, William E; Dickmann, Don; Hall, Richard

    2004-06-30

    The objective of this project was to extend previous poplar breeding and selection in the NC US by implementing a regional testing system with multiple test locations in Minnesota, Iowa, Wisconsin and Michigan.

  7. Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

    PubMed Central

    2012-01-01

    Background Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and also compensate for defects in viral replicative capacity (RC) due to a drug resistant protease. These NC/p1 changes are known to enhance processing of the Gag protein. To investigate the capacity of HIV-1 to modulate Gag cleavage and its consequences for PI resistance and RC, we performed a detailed enzymatic and virological analysis using a set of PI resistant NC/p1 variants (HXB2431V, HXB2436E+437T, HXB2437T and HXB2437V). Results Here, we demonstrate that single NC/p1 mutants, which displayed only a slight increase in PI resistance did not show an obvious change in RC. In contrast, the double NC/p1 mutant, which displayed a clear increase in processing efficiency and PI resistance, demonstrated a clear reduction in RC. Cleavage analysis showed that a tridecameric NC/p1 peptide representing the double NC/p1 mutant was cleaved in two specific ways instead of one. The observed decrease in RC for the double NC/p1 mutant (HXB2436E+437T) could (partially) be restored by either reversion of the 436E change or by acquisition of additional changes in the NC/p1 cleavage site at codon 435 or 438 as was revealed during in vitro evolution experiments. These changes not only restored RC but also reduced PI resistance levels. Furthermore these changes normalized Gag processing efficiency and obstructed the novel secondary cleavage site observed for the double NC/p1 mutant. Conclusions The results of this study clearly demonstrate that HIV-1 can modulate Gag processing and thereby PI resistance. Distinct increases in Gag cleavage and PI resistance result in a reduced RC that can only be restored by amino acid changes in NC/p1 which reduce Gag processing to an optimal rate. PMID:22462820

  8. Contrast inversion in nc-AFM on Si(111)7×7 due to short-range electrostatic interactions

    NASA Astrophysics Data System (ADS)

    Guggisberg, M.; Pfeiffer, O.; Schär, S.; Barwich, V.; Bammerlin, M.; Loppacher, C.; Bennewitz, R.; Baratoff, A.; Meyer, E.

    Contrast inversion in nc-AFM on Si(111)7×7 is observed at positive sample bias. Corner holes appear as protrusions and adatoms as holes. The application of negative bias voltages causes drastic changes in the atomic constrast. Frequency shift vs distance curves show evidence of short-range, voltage-dependent forces. These observations indicate that short-range electrostatic forces are important for atomic-scale contrast in nc-AFM.

  9. Serodiagnosis of Neospora caninum infection in cattle by enzyme-linked immunosorbent assay with recombinant truncated NcSAG1.

    PubMed

    Chahan, Bayin; Gaturaga, Irungu; Huang, Xiaohong; Liao, Min; Fukumoto, Shinya; Hirata, Haruyuki; Nishikawa, Yoshihumi; Suzuki, Hiroshi; Sugimoto, Chihiro; Nagasawa, Hideyuki; Fujisaki, Kozo; Igarashi, Ikuo; Mikami, Takeshi; Xuan, Xuenan

    2003-12-30

    Neospora caninum is a veterinary medically important pathogen capable of causing abortion in cattle and neuromuscular paralysis in dogs. The surface antigen 1 of N. caninum (NcSAG1) is an important candidate for the development of a diagnostic reagent for neosporosis. In order to establish an effective diagnostic method, the gene encoding truncated NcSAG1 (NcSAG1t) lacking a signal peptide and C-terminal hydrophobic regions was cloned and expressed in Escherichia coli as a fusion protein with glutathione S-transferase (GST). The purified GST-NcSAG1t was tested in an enzyme-linked immunosorbent assay (ELISA) for the detection of N. caninum antibodies in cattle. The ELISA with GST-NcSAG1t clearly differentiated between immunofluorescent antibody test (IFAT)-positive and -negative sera from cattle. In addition, the ELISA detected no cross-reactivity with sera from mice experimentally infected with the closely related parasite Toxoplasma gondii. Field serum samples collected from cattle in Brazil were examined for the diagnosis of neosporosis by using the ELISA. Of the 197 samples analyzed, 66 (33.5%) samples were positive for antibodies to N. caninum. Of the 66 ELISA-positive samples, 60 (90%) samples were confirmed as positive by Western blot analysis with whole parasite antigens. These results suggest that the recombinant NcSAG1t could be a reliable reagent for use as an antigen in ELISA for the serodiagnosis of N. caninum infection in cattle. PMID:14729165

  10. Cloning, Nucleotide Sequencing and Bioinformatics Study of NcSRS2 Gene, an Immunogen from Iranian Isolate of Neospora caninum

    PubMed Central

    Soltani, M; Sadrebazzaz, A; Nassiri, M; Tahmoorespoor, M

    2013-01-01

    Background Neosporosis is caused by an obligate intracellular parasitic protozoa Neospora caninum which infect variety of hosts. NcSRS2 is an immuno-dominant antigen of N. caninum which is considered as one of the most promising targets for a recombinant or DNA vaccine against neosporosis. As no study has been carried out to identify the molecular structure of N. caninum in Iran, as first step, we prepared a scheme to identify this gene in this parasite in Iran. Methods Tachyzoite total RNA was extracted and cDNA was synthesized and NcSRS2 gene was amplified using cDNA as template. Then the PCR product was cloned into pTZ57R/T vector and transformed into E. coli (DH5α strain). Finally, the recombinant plasmid was extracted from transformed E. coli and sequenced. Bioinformatics analysis also carried out. Results The PCR product of NcSRS2 gene was sequenced and recorded in GenBank. The deduced amino acid sequence of NcSRS2 in current study was compared with other N. caninum NcSRS2 and showed some identities and differences. Conclusion NcSRS2 gene of N. caninum successfully cloned in pTZ57R/T. Recombinant plasmid was confirmed by sequencing, colony PCR and enzymatic digestion. It is ready to express recombinant protein for further studies. PMID:23682269

  11. Transport of fullerene nanoparticles (nC60) in saturated sand and sandy soil: controlling factors and modeling.

    PubMed

    Zhang, Lunliang; Hou, Lei; Wang, Lilin; Kan, Amy T; Chen, Wei; Tomson, Mason B

    2012-07-01

    Understanding subsurface transport of fullerene nanoparticles (nC(60)) is of critical importance for the benign use and risk management of C(60). We examined the effects of several important environmental factors on nC(60) transport in saturated porous media. Decreasing flow velocity from approximately 10 to 1 m/d had little effect on nC(60) transport in Ottawa sand (mainly pure quartz), but significantly inhibited the transport in Lula soil (a sandy, low-organic-matter soil). The difference was attributable to the smaller grain size, more irregular and rougher shape, and greater heterogeneity of Lula soil. Increasing ionic strength and switching background solution from NaCl to CaCl(2) enhanced the deposition of nC(60) in both sand and soil columns, but the effects were more significant for soil. This was likely because the clay minerals (and possibly soil organic matter) in soil responded to changes of ionic strength and species differently than quartz. Anions in the mobile phase had little effect on nC(60) transport, and fulvic acid in the mobile phase (5.0 mg/L) had a small effect in the presence of 0.5 mM Ca(2+). A two-site transport model that takes into account both the blocking-affected attachment process and straining effects can effectively model the breakthrough of nC(60). PMID:22681192

  12. The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance.

    PubMed

    Ackley, B D; Crew, J R; Elamaa, H; Pihlajaniemi, T; Kuo, C J; Kramer, J M

    2001-03-19

    Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. The Caenorhabditis elegans collagen XVIII homologue, cle-1, encodes three developmentally regulated protein isoforms expressed predominantly in neurons. The CLE-1 protein is found in low amounts in all basement membranes but accumulates at high levels in the nervous system. Deletion of the cle-1 NC1 domain results in viable fertile animals that display multiple cell migration and axon guidance defects. Particular defects can be rescued by ectopic expression of the NC1 domain, which is shown to be capable of forming trimers. In contrast, expression of monomeric ES does not rescue but dominantly causes cell and axon migration defects that phenocopy the NC1 deletion, suggesting that ES inhibits the promigratory activity of the NC1 domain. These results indicate that the cle-1 NC1/ES domain regulates cell and axon migrations in C. elegans. PMID:11257122

  13. Kampo Medicines for Mite Antigen-Induced Allergic Dermatitis in NC/Nga Mice

    PubMed Central

    2005-01-01

    We have established an allergic dermatitis model in NC/Nga mice by repeated local exposure of mite antigen for analyzing atopic dermatitis. We examined how four Kampo medicines, Juzen-taiho-to, Hochu-ekki-to, Shofu-san and Oren-gedoku-to, on the dermatitis model to obtain basic information on their usefulness for treating atopic dermatitis. Mite antigen (Dermatophagoides farinae crude extract) solution at a concentration of 10 mg/ml was painted on the ear of NC/Nga mice after tape stripping. The procedure was repeated five times, at 7 day intervals. An apparent biphasic ear swelling was caused after the fourth and fifth antigen exposures with elevated serum IgE levels and accumulation of inflammatory cells. In the cervical lymph nodes and ear lobes, the five procedures of antigen exposure induced interleukin-4 mRNA expression but reduced interferon-γ mRNA expression. Oral administration of all four Kampo medicines inhibited the formation of ear swelling and inflammatory cell accumulation. Juzen-taiho-to and Hochu-ekki-to apparently prevented the elevation of serum IgE level. Furthermore, the four Kampo medicines showed a tendency to prevent not only the increase in interleukin-4 mRNA expression but also the decrease in interferon-γ mRNA expression. The present results indicate that Juzen-taiho-to, Hochu-ekki-to, Shofu-san and Oren-gedoku-to may correct the Th1/Th2 balance skewed to Th2, and this activity helps inhibit dermatitis in NC/Nga mice. The ability of the Kampo medicines to correct the Th1/Th2 balance seems to underlie their effectiveness in treating of atopic dermatitis. PMID:15937560

  14. PQCD study of the BSL and nc controversy in inclusive B decays

    NASA Astrophysics Data System (ADS)

    Chang, Chia-Hung V.; Chang, Darwin; Chang, We-Fu; Li, Hsiang-Nan; Yu, Hoi-Lai

    1998-11-01

    We calculate the semileptonic branching fraction and charm yield from inclusive B decays using the formalism of perturbative QCD. For nonleptonic decays, we employ the modified factorization theorem, in which Wilson coefficients evolve with the characteristic scales of the decay modes. It is found that the decay rate of the single-charm mode b-->cūd is enhanced, and a lower BSL is obtained without increasing nc. This conclusion differs from the usual one, where the b-->cc¯s mode is increased. Our result for the B meson lifetime is also consistent with the data.

  15. Federal Law on Consumer Deception: An Agency by Agency Analysis.

    ERIC Educational Resources Information Center

    Zweibel, George J.

    A comprehensive analysis of statutes and regulations on consumer deception administered by thirty government agencies is provided in this report. Each agency's chapter includes a brief description of the agency, and a detailed listing of all deceptive trade practices prohibited by that agency's enabling legislation, regulations, or other sources…

  16. 10 CFR 607.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Federal agency or agency. 607.645 Section 607.645 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.645 Federal agency or agency. Department of Energy means the...

  17. Effect of surfactants on the removal and acute toxicity of aqueous nC60 aggregates in water treatment process.

    PubMed

    Ge, Ling; Kirumba, George; Zhang, Bo; Pal, Amrita; He, Yiliang

    2015-07-01

    This work aimed to evaluate the effect of surfactants on the removal of aqueous nC60 aggregates by coagulation-filtration process and assess the acute toxicity of filtrates by Microtox test. Three surfactants including cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS), and Triton X-100 (TX100) were selected representing cationic, anionic, and nonionic types, respectively. Results showed that the change of physicochemical properties of nC60 associating with different types of surfactants determined nC60's removal efficiency and acute toxicity. CTAB increased the number of large particles. It also changed the zeta potential of nC60 from negative to positive, leading to the low removal rates (17.3-50.2%) when CTAB concentration was designed in the range of 0.03-1 g/L, and the filtrates showed acute toxicity to bioluminescent bacteria (inhibition rate > 80%). On the contrary, TX100 obviously increased the proportion of small particles, and it is noteworthy that even less than 1 mg/L of nC60 (20% of the initial concentration) with TX100 remaining in filtrates could evoke phototoxicity due to reactive oxygen species (ROS) generation under UV irradiation. Compared to CTAB and TX100, SDS exerted an effect on the removal process and toxicity of nC60 only when concentration was beyond the critical micelle concentration (CMC; 2.5 g/L). These findings collectively suggest that characteristics of nC60 are flexible and strongly dependent on surfactant modification, as a result of which these particles could potentially find their way through water treatment route and exert a potential toxicity risk. PMID:25631739

  18. Discovery of Novel ncRNA Sequences in Multiple Genome Alignments on the Basis of Conserved and Stable Secondary Structures.

    PubMed

    Fu, Yinghan; Xu, Zhenjiang Zech; Lu, Zhi J; Zhao, Shan; Mathews, David H

    2015-01-01

    Recently, non-coding RNAs (ncRNAs) have been discovered with novel functions, and it has been appreciated that there is pervasive transcription of genomes. Moreover, many novel ncRNAs are not conserved on the primary sequence level. Therefore, de novo computational ncRNA detection that is accurate and efficient is desirable. The purpose of this study is to develop a ncRNA detection method based on conservation of structure in more than two genomes. A new method called Multifind, using Multilign, was developed. Multilign predicts the common secondary structure for multiple input sequences. Multifind then uses measures of structure conservation to estimate the probability that the input sequences are a conserved ncRNA using a classification support vector machine. Multilign is based on Dynalign, which folds and aligns two sequences simultaneously using a scoring scheme that does not include sequence identity; its structure prediction quality is therefore not affected by input sequence diversity. Additionally, ensemble defect was introduced to Multifind as an additional discriminating feature that quantifies the compactness of the folding space for a sequence. Benchmarks showed Multifind performs better than RNAz and LocARNATE+RNAz, a method that uses RNAz on structure alignments generated by LocARNATE, on testing sequences extracted from the Rfam database. For de novo ncRNA discovery in three genomes, Multifind and LocARNATE+RNAz had an advantage over RNAz in low similarity regions of genome alignments. Additionally, Multifind and LocARNATE+RNAz found different subsets of known ncRNA sequences, suggesting the two approaches are complementary. PMID:26075601

  19. Photoinduced Charge Transfer and Electrochemical Properties of Triphenylamine Ih-Sc3N@C80 Donor-Acceptor Conjugates

    PubMed Central

    Pinzón, Julio R.; Gasca, Diana C.; Shankara, Gayathri. S; Bottari, Giovanni; Torres, Tomás; Guldi, Dirk M.; Echegoyen, Luis

    2009-01-01

    Two isomeric [5,6]-pyrrolidine-Ih-Sc3N@C80 electron donor acceptor conjugates containing triphenylamine (TPA) as the donor system were synthesized. Electrochemical and photophysical studies of the novel conjugates were made and compared with those of their C60 analogues, in order to determine i) the effect of the linkage position (N-substituted versus 2-substituted pyrrolidine) of the donor system in the formation of photoinduced charge separated states, ii) the thermal stability towards the retro-cycloaddition reaction and iii) the effect of changing C60 for Ih-Sc3N@C80 as the electron acceptor. It was found that when the donor is connected to the pyrrolidine nitrogen atom, the resulting dyad produces a significantly longer lived radical pair than the corresponding 2-substituted isomer for both the C60 and Ih-Sc3N@C80 dyads. In addition to that, the N-substituted TPA-Ih-Sc3N@C80 dyad has much better thermal stability than the 2-subtituted one. Finally, the Ih-Sc3N@C80 dyads have considerably longer lived charge separated states than their C60 analogues, thus approving the advantage of using Ih-Sc3N@C80 instead of C60 as the acceptor for the construction of fullerene based donor acceptor conjugates. These findings are important for the design and future application of Ih-Sc3N@C80 dyads as materials for the construction of plastic organic solar cells. PMID:19445462

  20. Cataloging on-line health information: a content analysis of the NC Health Info portal.

    PubMed

    Blake, Catherine; West, David; Luo, Lili; Marchionini, Gary

    2005-01-01

    The unrelenting increase of health information on the World Wide Web has resulted in an urgent need for portals that provide consumers with trustworthy health information. In response to this need, the National Library of Medicine initiated the Go Local initiative, which extends MEDLINEplus by providing consumers with links to local health services, programs and providers. NC Health Info (www.nchealthinfo.org) is the first NIH funded Go Local portal. Our goal is to gain insight into the nature of interactions that occur during the cataloging process of online health information resources. We conducted a content analysis of annotations made by catalogers on the NC Health Info portal between January 2000 and September 2004. Our analysis of 2369 online information resources revealed challenges with establishing the navigational, geographical and topical content of an on-line resource. Our analysis provides insight into the mechanisms that catalogers use to overcome those challenges and thus will be of value to future Go Local portal development. PMID:16779001

  1. Complex 2D matrix model and geometrical map on the complex-Nc plane

    NASA Astrophysics Data System (ADS)

    Nawa, Kanabu; Ozaki, Sho; Nagahiro, Hideko; Jido, Daisuke; Hosaka, Atsushi

    2013-08-01

    We study the parameter dependence of the internal structure of resonance states by formulating a complex two-dimensional (2D) matrix model, where the two dimensions represent two levels of resonances. We calculate a critical value of the parameter at which a "nature transition" with character exchange occurs between two resonance states, from the viewpoint of geometry on complex-parameter space. Such a critical value is useful for identifying the internal structure of resonance states with variation of the parameter in the system. We apply the model to analyze the internal structure of hadrons with variation of the color number N_c from infty to a realistic value 3. By regarding 1/N_c as the variable parameter in our model, we calculate a critical color number of the nature transition between hadronic states in terms of a quark-antiquark pair and a mesonic molecule as exotics from the geometry on the complex-N_c plane. For large-N_c effective theory, we employ the chiral Lagrangian induced by holographic QCD with a D4/D8/overline {D8} multi-D brane system in type IIA superstring theory.

  2. Updated 1 /Nc expansion analysis of [56 ,2+] and [70 ,ℓ+] baryon multiplets

    NASA Astrophysics Data System (ADS)

    Matagne, N.; Stancu, Fl.

    2016-05-01

    The mass spectra of the [56 ,2+] and [70 ,ℓ+ ] multiplets, both belonging to the N =2 band, are reviewed in the 1 /Nc expansion method. Previous studies, separately made for each multiplet, are presently updated to the 2014 Particle Data Group. The mass formula, including corrections up to O (1 /Nc) and first order in SU(3) flavor symmetry breaking, has the same independent operator basis in both cases. A special emphasis is made on the role of the SU(3) symmetry breaking operators Bi (i =1 ,2 ,3 ). This can allow for multiplet assignment of Λ and Σ hyperons, which generally is quite difficult to make. Tentative assignments of hyperons with two- and one-star resonances are made to the [70 ,ℓ+ ] multiplet. Another important aim is to find out whether or not a common value of the coefficient c1 of the dominant operator in the mass formula can well fit the present data in both multiplets. A negative answer, which is here the case, implies distinct Regge trajectories for symmetric and mixed symmetric states.

  3. Andrew Wyeth and N.C. Wyeth: a psychodynamic perspective on father and son.

    PubMed

    Shaw, Jon A

    2013-01-01

    This paper examines the relationship between two extraordinary artists, father and son--N.C. Wyeth (1882-1945) and Andrew Wyeth (1917-2009)--and their art. N.C. Wyeth, the father, the most famous illustrator of his day, painted scenes full of drama and action, often of men engaged in violent life and death struggles. N.C. was unable to separate from his powerful mother and yearned for his iconic father. He thought himself an artistic failure and dedicated himself to raising his children to be geniuses. The youngest son, Andrew Wyeth, who lived a "secret life," painted scenes often characterized by pathos: bleak and barren landscapes, leaden skies, tire tracks, gray framed houses, desiccated fields, and circling buzzards. In the father-son relationship, we often seen three themes perpetuated developmentally: (1) the son's identification with the innermost conflicts of his father; (2) the yearning for the iconic father of his youth; and (3) a continuation and disavowal of his father's life. These themes are played out in the relationship between Andrew Wyeth and his father. PMID:23965259

  4. APeg3: regulation of Peg3 through an evolutionarily conserved ncRNA

    PubMed Central

    Frey, Wesley D.

    2014-01-01

    Mammalian APeg3 is an antisense gene that is localized within the 3′-untranslated region of the imprinted gene, Peg3. APeg3 is expressed only in the vasopressinergic neurons of the hypothalamus, thus is predicted to play significant roles in this specific area of the brain. In the current study, we investigate the functions of APeg3 with comparative genomics and cell line-based functional approaches. The transcribed region of APeg3 displays high levels of sequence conservation among placental mammals, but without any obvious open reading frame, suggesting that APeg3 may have been selected as a ncRNA gene during eutherian evolution. This has been further supported by the detection of a conserved local RNA secondary structure within APeg3. RNA secondary structure analyses indicate a single conserved hairpin-loop structure towards the 5′ end of the transcript. The results from cell line-based transfection experiments demonstrate that APeg3 has the potential to down-regulate the transcription and protein levels of Peg3. The observed down-regulation by APeg3 is also somewhat orientation-independent. Overall, these results suggest that APeg3 has evolved as a ncRNA gene and controls the function of its sense gene Peg3 within specific neuronal cells. PMID:24582979

  5. Social Factors as Modifiers of Hurricane Irene Evacuation Behavior in Beaufort County, NC

    PubMed Central

    Ricchetti-Masterson, Kristen; Horney, Jennifer

    2013-01-01

    Encouraging residents in high-risk areas to evacuate before a hurricane makes landfall is one of the few ways to reduce hurricane-related morbidity and mortality. However, demographic factors associated with evacuation in at-risk groups have not been consistent across studies. To determine if social factors (social control, social cohesion, and social capital) modified the relationship between demographic groups and failure to evacuate from Hurricane Irene, the authors conducted a cross-sectional stratified two-stage cluster sample among residents of Beaufort County, NC. Of 226 attempted rapid response interviews, 205 were completed (response rate = 90.7%). Data were analyzed using generalized linear modeling, which produced crude risk differences to estimate the association between failure to evacuate from Hurricane Irene and a number of demographic and social factors; effect measure modification (EMM) was assessed on the additive scale through stratified analyses of key social factors. There were no significant associations between demographic or social factors and evacuation in the bivariate analysis. However, EMM was present for households with high social capital or social cohesion among special needs residents, those over age 65, males, and non-whites. In Beaufort County, NC, future hazard mitigation plans should include evacuation messages tailored for households with high social capital or social cohesion. PMID:23788200

  6. Youth Media and Agency

    ERIC Educational Resources Information Center

    Hauge, Chelsey

    2014-01-01

    This article addresses how capacity is conceived of and understood in youth media/civic education programming, and how beliefs about agency, development, relationality and youth manifests in the discourses, programmes, and practices of organizations operating youth media programmes. Through attention to a youth media and development programme in…

  7. Metacognition of Agency

    ERIC Educational Resources Information Center

    Metcalfe, Janet; Greene, Matthew Jason

    2007-01-01

    The feeling that we are agents, intentionally making things happen by our own actions, is foundational to our understanding of ourselves as humans. People's metacognitions of agency were investigated in 4 experiments. Participants played a game in which they tried to touch downward scrolling Xs and avoid touching Os. Variables that affected…

  8. Other Federal Agencies

    ERIC Educational Resources Information Center

    Design and Environment, 1971

    1971-01-01

    Briefly reviews the man-environment research sponsored by these eight government agencies: Departments of Agriculture, Commerce, Defense, Interior, Justice, the Office of Economic Opportunity, the National Aeronautics and Space Administration, and the National Science Foundation. The Man-Environment Research survey report was the source of…

  9. Strengthening Career Human Agency

    ERIC Educational Resources Information Center

    Chen, Charles P.

    2006-01-01

    Rooted in A. Bandura's (1982, 2001b) social cognitive theory, the notion of human agency has received considerable attention in vocational and career psychology for the last 2 decades, especially with the recent emergence of social constructivist thinking in the field. This article continues in the same direction. In reviewing the notion of human…

  10. Metacognition of agency.

    PubMed

    Metcalfe, Janet; Greene, Matthew Jason

    2007-05-01

    The feeling that we are agents, intentionally making things happen by our own actions, is foundational to our understanding of ourselves as humans. People's metacognitions of agency were investigated in 4 experiments. Participants played a game in which they tried to touch downward scrolling Xs and avoid touching Os. Variables that affected accuracy included speed of the scroll, density of the targets, and feedback. Of central interest were variables directed not only at accuracy but also at people's control: the turbulence of the cursor and how close the cursor had to come to the target for a hit (i.e., "magic"). After each trial, people made judgments of agency or judgments of performance. People were selectively sensitive to the variables to which they should be responsive in agency monitoring--whether the cursor moved in close synchrony to their movements and whether targets disappeared by magic. People knew, separably from their objective or judged performance, when they were in control and when they were not. These results indicate that people can sensitively monitor their own agency. PMID:17500645

  11. Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

    PubMed Central

    Butryn, Agata; Schuller, Jan M; Stoehr, Gabriele; Runge-Wollmann, Petra; Förster, Friedrich; Auble, David T; Hopfner, Karl-Peter

    2015-01-01

    Swi2/Snf2 ATPases remodel substrates such as nucleosomes and transcription complexes to control a wide range of DNA-associated processes, but detailed structural information on the ATP-dependent remodeling reactions is largely absent. The single subunit remodeler Mot1 (modifier of transcription 1) dissociates TATA box-binding protein (TBP):DNA complexes, offering a useful system to address the structural mechanisms of Swi2/Snf2 ATPases. Here, we report the crystal structure of the N-terminal domain of Mot1 in complex with TBP, DNA, and the transcription regulator negative cofactor 2 (NC2). Our data show that Mot1 reduces DNA:NC2 interactions and unbends DNA as compared to the TBP:DNA:NC2 state, suggesting that Mot1 primes TBP:NC2 displacement in an ATP-independent manner. Electron microscopy and cross-linking data suggest that the Swi2/Snf2 domain of Mot1 associates with the upstream DNA and the histone fold of NC2, thereby revealing parallels to some nucleosome remodelers. This study provides a structural framework for how a Swi2/Snf2 ATPase interacts with its substrate DNA:protein complex. DOI: http://dx.doi.org/10.7554/eLife.07432.001 PMID:26258880

  12. Subcellular localization and functional characterization of Nc-p43, a major Neospora caninum tachyzoite surface protein.

    PubMed Central

    Hemphill, A

    1996-01-01

    Neospora caninum is a recently identified coccidian parasite which shares many features with, but is clearly distinct from, Toxoplasma gondii. N. caninum tachyzoites infect a wide range of mammalian cells both in vivo and in vitro. The mechanisms by which infection is achieved are largely unknown. Recent evidence has suggested that a receptor-ligand system in which one or several host cell receptors bind to one or several parasite ligands is involved. Parasite cell surface-associated molecules such as the recently identified Nc-p43 antigen are prime suspects for being implicated in this physical interaction. In this study it is shown that invasion of Vero cell monolayers by N. caninum tachyzoites in vitro is impaired on incubation of parasites with subagglutinating amounts of affinity-purified antibodies directed against Nc-p43. Postembedding immunogold labeling with anti-Nc-p43 antibodies demonstrated that Nc-p43 is localized not only on the parasite cell surface but also within dense granules and rhoptries. The fate of Nc-p43 during intracellular proliferation of N. caninum tachyzoites and subsequent maturation of the parasitophorous vacuole was also studied. PMID:8926100

  13. MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis

    PubMed Central

    Rebustini, Ivan T.; Myers, Christopher; Lassiter, Keyonica S.; Surmak, Andrew; Szabova, Ludmila; Holmbeck, Kenn; Pedchenko, Vadim; Hudson, Billy G.; Hoffman, Matthew P.

    2009-01-01

    Summary Proteolysis is essential during branching morphogenesis, but the roles of MT-MMPs and their proteolytic products are not clearly understood. Here we discover that decreasing MT-MMP activity during submandibular gland branching morphogenesis decreases proliferation and increases collagen IV and MT-MMP expression. Importantly, reducing epithelial MT2-MMP profoundly decreases proliferation and morphogenesis, increases Col4a2 and intracellular accumulation of collagen IV, and decreases the proteolytic release of collagen IV NC1 domains. Importantly, we demonstrate the presence of collagen IV NC1 domains in developing tissue. Furthermore, recombinant collagen IV NC1 domains rescue branching morphogenesis after MT2-siRNA-treatment, increasing MT-MMP and pro-proliferative gene expression via β1 integrin and PI3K-AKT signaling. Additionally, HBEGF also rescues MT2-siRNA-treatment, increasing NC1 domain release, proliferation, and MT2-MMP and Hbegf expression. Our studies provide mechanistic insight into how MT2-MMP-dependent release of bioactive NC1 domains from collagen IV is critical for integrating collagen IV synthesis and proteolysis with epithelial proliferation during branching morphogenesis. PMID:19853562

  14. Tunable photoluminescence from nc-Si/a-SiNx:H quantum dot thin films prepared by ICP-CVD.

    PubMed

    Sain, Basudeb; Das, Debajyoti

    2013-03-21

    Intense visible photoluminescence (PL) tunable within 1.66-2.47 eV, under UV 325 nm excitation, was obtained from nanocrystalline silicon quantum dots (∼5.72-1.67 nm in diameter) embedded in amorphous silicon-nitride matrix (nc-Si/a-SiN(x):H) prepared in RF-ICPCVD (13.56 MHz) at substrate temperatures between 400 to 150 °C. The dominant component of PL, having a narrow band width of ∼0.16-0.45 eV, originates from quasi-direct band-to-band recombination due to quantum confinement effect (QCE) in the nanocrystalline silicon quantum dots (nc-Si QDs) of appropriate size; however, the contribution of defects arose at lower substrate temperatures leading to asymmetric broadening. Intense atomic hydrogen flux in high-density inductively coupled plasmas (ICPs) provides a very high surface coverage, passivates well the nonradiative dangling bonds, and thereby favors the PL intensity. The average size of nc-Si QDs measured by HR-TEM appears consistent with similar estimates from Raman studies. The red shift of the Raman line and corresponding line broadening originates from the confinement of optical phonons within nc-Si QDs. Photoluminescence emerging from nc-Si/a-SiN(x):H quantum dots obtained from the low temperature and single-step plasma processing holds great promise for the fabrication of light-emitting devices and flexible flat panel displays. PMID:23407687

  15. Prediction of the Spectroscopic Parameters of New Iron Compounds: Hydride of Iron Cyanide/Isocyanide, HFeCN/HFeNC

    NASA Astrophysics Data System (ADS)

    Redondo, Pilar; Barrientos, Carmen; Largo, Antonio

    2016-09-01

    Iron is the most abundant transition metal in space. Its abundance is similar to that of magnesium, and until today only, FeO and FeCN have been detected. However, magnesium-bearing compounds such as MgCN, MgNC, and HMgNC are found in IRC+10216. It seems that the hydrides of iron cyanide/isocyanide could be good candidates to be present in space. In the present work we carried out a characterization of the different minima on the quintet and triplet [C, Fe, H, N] potential energy surfaces, employing several theoretical approaches. The most stable isomers are predicted to be hydride of iron cyanide HFeCN, and isocyanide HFeNC, in their 5Δ states. Both isomers are found to be quasi-isoenergetics. The HFeNC isomer is predicted to lie about 0.5 kcal/mol below HFeCN. The barrier for the interconversion process is estimated to be around 6.0 kcal/mol, making this process unfeasible under low temperature conditions, such as those in the interstellar medium. Therefore, both HFeCN and HFeNC could be candidates for their detection. We report geometrical parameters, vibrational frequencies, and rotational constants that could help with their experimental characterization.

  16. Normativity, agency, and life.

    PubMed

    Barham, James

    2012-03-01

    There is an immense philosophical literature dealing with the notions of normativity and agency, as well as a sizeable and rapidly growing scientific literature on the topic of autonomous agents. However, there has been very little cross-fertilization between these two literatures. As a result, the philosophical literature tends to assume a somewhat outdated mechanistic image of living things, resulting in a quasi-dualistic picture in which only human beings, or the higher animals, can be normative agents properly speaking. From this perspective, the project of 'naturalizing normativity' becomes almost a contradiction in terms. At the same time, the scientific literature tends to misuse 'normativity,' 'agency,' and related terms, assuming that it is meaningful to ascribe these concepts to 'autonomous agents' conceived of as physical systems whose behavior is to be explained in terms of ordinary physical law. From this perspective, the true depth of the difficulty involved in understanding what makes living systems distinctive qua physical systems becomes occluded. In this essay, I begin the attempt to remedy this situation. After some preliminary discussion of terminology and situating of my project within the contemporary philosophical landscape, I make a distinction between two different aspects of the project of naturalizing normativity: (1) the 'Scope Problem,' which consists in saying how widely in nature our concept of normative agency may properly be applied; and (2) the 'Ground Problem,' which consists in rationalizing the phenomenon of normative agency in terms of the rest of our knowledge of nature. Then, in the remainder of this paper, I argue that the Scope Problem ought to be resolved in favor of attributing normative agency, in the proper sense of those words, to living things as such. The Ground Problem will be discussed in a companion paper at a later time. PMID:22326078

  17. Effects of aqueous stable fullerene nanocrystal (nC60) on copper (trace necessary nutrient metal): Enhanced toxicity and accumulation of copper in Daphnia magna.

    PubMed

    Tao, Xianji; He, Yiliang; Fortner, John D; Chen, Yongsheng; Hughes, Joseph B

    2013-08-01

    Our focus herein is to evaluate the potential interaction between nC60 and copper, a trace necessary metal, in light of the impact on toxicity. The non-observable effects concentration (NOEC) of nC60 was confirmed as 100μgL(-1) before. When Daphnia magna was exposed to the mixture of copper solution and nC60 suspension (100μgL(-1)), LC50 of 48h was lower than that when they were exposed to copper solution alone. This result clearly showed the decrease in NOEC of copper at the presence of nC60. Cu(2+)-ATPase activity was enhanced at the presence of nC60, indicating that copper transport involved with the uptake, distribution and depuration in body was increased. We further conducted experiments on accumulation of copper in D. magna. The observed equilibrium copper concentration in D. magna in the mixture of 100μgL(-1) nC60 and 1μgL(-1) copper solution reached 131μg (kg wet weight)(-1), which was more than twice that in copper solution only: 60μg (kg wet weight)(-1). This result demonstrated that the accumulation of copper in D. magna was significantly enhanced at the presence of even low nC60 concentration. Experiments also showed that copper was quickly adsorbed onto nC60. The absorption of copper onto D. magna was statistically correlated to the absorption of nC60 onto D. magna; this might be caused by nC60 facilitating the transfer of copper into D. magna. The absorption and desorption of copper to nC60 (pH=5.0) reached equilibrium quickly, which may be involved with the co-bioaccumulation and decrease in NOEC of Cu(2+) and nC60. PMID:23755985

  18. Identification and comparative analysis of ncRNAs in human, mouse and zebrafish indicate a conserved role in regulation of genes expressed in brain.

    PubMed

    Qu, Zhipeng; Adelson, David L

    2012-01-01

    ncRNAs (non-coding RNAs), in particular long ncRNAs, represent a significant proportion of the vertebrate transcriptome and probably regulate many biological processes. We used publically available ESTs (Expressed Sequence Tags) from human, mouse and zebrafish and a previously published analysis pipeline to annotate and analyze the vertebrate non-protein-coding transcriptome. Comparative analysis confirmed some previously described features of intergenic ncRNAs, such as a positionally biased distribution with respect to regulatory or development related protein-coding genes, and weak but clear sequence conservation across species. Significantly, comparative analysis of developmental and regulatory genes proximate to long ncRNAs indicated that the only conserved relationship of these genes to neighbor long ncRNAs was with respect to genes expressed in human brain, suggesting a conserved, ncRNA cis-regulatory network in vertebrate nervous system development. Most of the relationships between long ncRNAs and proximate coding genes were not conserved, providing evidence for the rapid evolution of species-specific gene associated long ncRNAs. We have reconstructed and annotated over 130,000 long ncRNAs in these three species, providing a significantly expanded number of candidates for functional testing by the research community. PMID:23284966

  19. Agency, time, and causality

    PubMed Central

    Widlok, Thomas

    2014-01-01

    Cognitive Scientists interested in causal cognition increasingly search for evidence from non-Western Educational Industrial Rich Democratic people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition. PMID:25414683

  20. Research on Error Modelling and Identification of 3 Axis NC Machine Tools Based on Cross Grid Encoder Measurement

    NASA Astrophysics Data System (ADS)

    Du, Z. C.; Lv, C. F.; Hong, M. S.

    2006-10-01

    A new error modelling and identification method based on the cross grid encoder is proposed in this paper. Generally, there are 21 error components in the geometric error of the 3 axis NC machine tools. However according our theoretical analysis, the squareness error among different guide ways affects not only the translation error component, but also the rotational ones. Therefore, a revised synthetic error model is developed. And the mapping relationship between the error component and radial motion error of round workpiece manufactured on the NC machine tools are deduced. This mapping relationship shows that the radial error of circular motion is the comprehensive function result of all the error components of link, worktable, sliding table and main spindle block. Aiming to overcome the solution singularity shortcoming of traditional error component identification method, a new multi-step identification method of error component by using the Cross Grid Encoder measurement technology is proposed based on the kinematic error model of NC machine tool. Firstly, the 12 translational error components of the NC machine tool are measured and identified by using the least square method (LSM) when the NC machine tools go linear motion in the three orthogonal planes: XOY plane, XOZ plane and YOZ plane. Secondly, the circular error tracks are measured when the NC machine tools go circular motion in the same above orthogonal planes by using the cross grid encoder Heidenhain KGM 182. Therefore 9 rotational errors can be identified by using LSM. Finally the experimental validation of the above modelling theory and identification method is carried out in the 3 axis CNC vertical machining centre Cincinnati 750 Arrow. The entire 21 error components have been successfully measured out by the above method. Research shows the multi-step modelling and identification method is very suitable for 'on machine measurement'.

  1. Assessment of phthalate-induced changes in fetal rat testis gene expression using an rt-PCR array

    EPA Science Inventory

    Lambright, CS’, Sampson, H2, Furr, i1, Evans, N’, Hannas, B’, Gray, LE, Jr.’, VS Wilson1. 1USEPA, NHEERL, RTP, NC, 2USEPA, NHEERL, RTP, NC, ORISE Fellow. Phthalate esters (PE) such as diethyl hexyl phthalate (DEHP) produce reproductive malformations in male rodents by reduction o...

  2. ENVIRONMENTAL POLLUTION AND THE IMMUNE SYSTEM: MECHANISMS OF IMMUNOTOXICITY ACROSS PHYLA

    EPA Science Inventory

    Environmental pollution and the immune system: Mechanisms of immunotoxicity across phyla. Bob Luebke and Dori Germolec, US EPA, RTP, NC and NIEHS, RTP, NC

    Our current understanding of immunotoxicology comes largely from studies done in rodents or using in vitro systems, a...

  3. DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE

    EPA Science Inventory

    DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE. TL Leavens1, MW Case1, RA Pegram1, BC Blount2, DM DeMarini1, MC Madden1, and JL Valentine3. 1NHEERL, USEPA, RTP, NC, USA; 2CDC, Atlanta, GA, USA; 3RTI, RTP, NC, USA.
    The disinfection byproduct ...

  4. Effects of Organophosphorus Flame Retardants on Spontaneous Activity in Neuronal Networks Grown on Microelectrode Arrays

    EPA Science Inventory

    EFFECTS OF ORGANOPHOSPHORUS FLAME RETARDANTS ON SPONTANEOUS ACTIVITY IN NEURONAL NETWORKS GROWN ON MICROELECTRODE ARRAYS TJ Shafer1, K Wallace1, WR Mundy1, M Behl2,. 1Integrated Systems Toxicology Division, NHEERL, USEPA, RTP, NC, USA, 2National Toxicology Program, NIEHS, RTP, NC...

  5. EFFECTS OF DIESEL EXHAUST ON PULMONARY RESPONSES DURING ALLERGIC SENSITIZATION TO AEROSOLIZED OVALBUMIN IN BALB/C MICE

    EPA Science Inventory

    Effects of Diesel Exhaust on Pulmonary Responses During Allergic Sensitization to Aerosolized Ovalbumin in BALB/c Mice. P. Singh1, M.J. Daniels1, D. Andrews1, E. Boykin1, W. P. Linak2 and M.I. Gilmour1. 1USEPA, ORD, NHEERL, RTP, NC. 2 USEPA, ORD, NRMRL, RTP, NC.

    Inhala...

  6. Cellular Stress Response to Engineered Nanoparticles: Effect of Size, Surface Coating, and Cellular Uptake

    EPA Science Inventory

    CELLULAR STRESS RESPONSE TO ENGINEERED NANOPARTICLES: EFFECT OF SIZE, SURFACE COATING, AND CELLULAR UPTAKE RY Prasad 1, JK McGee2, MG Killius1 D Ackerman2, CF Blackman2 DM DeMarini2 , SO Simmons2 1 Student Services Contractor, US EPA, RTP, NC 2 US EPA, RTP, NC The num...

  7. MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10

    PubMed Central

    Qi, Ying; Ooi, Hong Sain; Wu, Jun; Chen, Jian; Zhang, Xiaoli; Tan, Sheng; Yu, Qing; Li, Yuan-Yuan; Kang, Yani; Li, Hua; Xiong, Zirui; Zhu, Tao; Liu, Bingya; Shao, Zhifeng; Zhao, Xiaodong

    2016-01-01

    EZH2, the catalytic component of polycomb repressive complex 2 (PRC2), is frequently overexpressed in human cancers and contributes to tumor initiation and progression, in part through transcriptional silencing of tumor suppressor genes. A number of noncoding RNAs (ncRNAs) recruit EZH2 to specific chromatin loci, where they modulate gene expression. Here, we used RNA immunoprecipitation sequencing (RIP-seq) to profile EZH2-associated transcripts in human gastric cancer cell lines. We identified 8,256 transcripts, including both noncoding and coding transcripts, some of which were derived from cancer-related loci. In particular, we found that long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion. Our work thus provides a global view of the EZH2-associated transcriptome and offers new insight into the function of EZH2 in gastric tumorigenesis. PMID:26871474

  8. Rebamipide suppresses mite-induced asthmatic responses in NC/Nga mice.

    PubMed

    Murakami, Ikuo; Zhang, Ran; Kubo, Masayuki; Nagaoka, Kenjiro; Eguchi, Eri; Ogino, Keiki

    2015-10-15

    Allergic asthma caused by continuous allergen exposure evokes allergen-specific Th2 responses and is characterized by chronic airway inflammation and hyperresponsiveness. A previous report showed that rebamipide improved asthmatic symptoms in an ovalbumin/trypsin mice model. However, it is still unclear how rebamipide exerts its effects in asthma. In this study, rebamipide improved the asthmatic responses induced by mite exposure in NC/Nga mice, revealing the mechanism of this therapeutic effect. Rebamipide suppressed the infiltration of eosinophils into the airways and lung as well as attenuating the production of reactive oxygen species in tissues. In addition to these anti-inflammatory effects, rebamipide inhibited the production of IL-33, a member of the IL-1 family that drives the subsequent production of Th2-associated cytokines. These observations identify the point where rebamipide exerts its suppressive action on asthma and suggest that rebamipide has therapeutic potential in preventing mite-induced asthma. PMID:26472814

  9. Coherent chemistry with THz pulses: Ultrafast field-driven isomerization of LiNC

    NASA Astrophysics Data System (ADS)

    Pellouchoud, L. A.; Reed, E. J.

    2015-05-01

    The ability to coherently rearrange structures at the atomic scale is among the grand challenges of physical science. Some of the primary obstacles are nonadiabatic increases in energy, such as intramolecular vibrational relaxation (IVR) and electronic excitations. Motivated by recent advances in strong terahertz (THz) pulse generation, we investigate the potential of THz to circumvent these obstacles. Employing TDDFT-Ehrenfest simulations, we discover that strong THz pulses can drive isomerization of the LiNC molecule over barriers greater than 0.2 eV with very low ionization rates and, in the best case, less than 3 meV of residual excess energy. This work points to new possibilities in predictively manipulating chemical bonds in molecules and materials.

  10. Synthesis of nc-UO2 by controlled precipitation in aqueous phase

    NASA Astrophysics Data System (ADS)

    Jovani-Abril, R.; Gibilaro, M.; Janßen, A.; Eloirdi, R.; Somers, J.; Spino, J.; Malmbeck, R.

    2016-08-01

    Nanocrystalline UO2 has been produced through controlled precipitation from an electrolytically reduced U(IV) solution. The reduction process of U(VI) to U(IV) was investigated by cyclic voltammetry in combination with absorption spectrophotometry. Precipitation was achieved by controlled alkalinisation following closely the solubility line of U(IV) in aqueous media. The highest starting concentration used was 0.5 M uranylnitrate which yielded, with the equipment used, around 10 g material pro batch. The produced nc-UO2 was characterised by transmission electron microscopy (TEM) and x-ray diffraction (XRD) and exhibited the typical UO2+x fcc fluorite structure with an average crystallite size of 3.9 nm.

  11. Perceived discrimination among Latino immigrants in new destinations: The case of Durham, NC1

    PubMed Central

    Flippen, Chenoa A.; Parrado, Emilio A.

    2015-01-01

    This paper draws on original survey data to assess the prevalence of perceived discrimination among Latin American immigrants to Durham, NC, a “new immigrant destinations” in the Southeastern United States. Even though discrimination has a wide-ranging impact on social groups, from blocked opportunities, to adverse health outcomes, to highlighting and reifying inter-group boundaries, research among immigrant Latinos is rare, especially in new destinations. Our theoretical framework and empirical analysis expand social constructivist approaches that view ethnic discrimination as emerging from processes of competition and incorporation. We broaden prior discussions by investigating the specific social forces that give rise to perceived discrimination. In particular, we examine the extent to which perceptions of unequal treatment vary by gender, elaborating on the situational conditions than differentiate discrimination experiences for men and women. We also incorporate dimensions unique to the contemporary Latino immigrant experience, such as legal status, family migration dynamics, and transnationalism. PMID:26848208

  12. Signatures in Martian Volatiles and the Magma Sources of NC Meteorites

    NASA Technical Reports Server (NTRS)

    Marti, K.; Mathew, K. J.

    2004-01-01

    We report nitrogen and xenon isotopic signatures in Yamato nakhlites and use the data to assess properties of the magma source of NC meteorites in planet Mars. The Chassigny meteorite was investigated by Floran et al, who classified it as a cumulate dunite with hydrous amphibole-bearing melt inclusions with no preferred orientation of the olivines. Their inferred composition of the parent magma, which was based on electron microprobe analyses, has been questioned. The trace and minor elements in minerals were analyzed in nakhlites and in Chassigny and the authors conclude that nakhlites may represent samples from different horizons of the same lithologic unit, but that Chassigny was not co-magmatic with the nakhlites.

  13. Complete sequence and characterization of mitochondrial and chloroplast genome of Chlorella variabilis NC64A.

    PubMed

    Orsini, Massimiliano; Costelli, Cristina; Malavasi, Veronica; Cusano, Roberto; Concas, Alessandro; Angius, Andrea; Cao, Giacomo

    2016-09-01

    The complete nucleotide sequences of the mitochondrial (mtDNA) and chloroplast (cpDNA) genomes of Chlorella variabilis NC64A (Trebouxiophyceae) have been determined in this study (GenBank accession no. KP271968 and KP271969, respectively). The mt genome assembles as a circle of 78,500 bp and contains 62 genes, including 32 protein-coding, 27 tRNA and 3 rRNA genes. The overall GC content is 28.2%, while the coding sequence is 34%. The cp genome forms a circle of 124,793 bp, containing 114 genes, including 79 protein-coding, 32 tRNA and 3 rRNA genes. The overall GC content is 33,9%, while the coding sequence is 50%. PMID:25690053

  14. Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC/Nga mice.

    PubMed

    Ahn, Ji Young; Choi, Sun Eun; Jeong, Mi Sook; Park, Kwan Hee; Moon, Nam Ju; Joo, Seong Soo; Lee, Chung Soo; Choi, Young Wook; Li, Kapsok; Lee, Mi-Kyung; Lee, Min Won; Seo, Seong Jun

    2010-07-01

    Increased levels of eosinphils, IgE, IL-4, 5, and 13 and pro-inflammatory factors (COX-2, iNOS) are observed in patients with atopic dermatitis (AD). Taxifolin 3-O-beta-D-glucopyranoside (TAX) from the roots of Rhododendron mucronulatum (RM) was examined to determine whether its immunomodulatory effect was applicable for treating atopic dermatitis.A total of 7 groups of NC/Nga mice with AD were treated by topical application or intraperitoneal injection of TAX for 4 weeks. Follow-up evaluations were done to assess the changes in clinical observations, eosinophil counts, and levels of IgE, cytokines, COX-2 and iNOS.In the clinical observation during the experimental period, TAX treatment significantly reduced the severity of AD-like lesions induced in NC/Nga mice. Eosinophil and IgE levels decreased after treatment of the animals with TAX. TAX may thus be associated with improvement of eosinophil-related allergic diseases. The expression of cytokines (IL-4, 5 and 13) was significantly inhibited in the TAX-treated group, suggesting that TAX might play an immunoregulatory role associated with AD. In RT-PCR, iNOS and COX-2 expression levels were reduced in the TAX-treated group. In western blotting, the expression levels of iNOS and COX-2 were also reduced in the TAX-treated group.These findings suggest that TAX is effective for the treatment of AD by preventing the production of inflammatory cytokines and by reducing skin inflammation. PMID:20041431

  15. 14 CFR 1267.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Federal agency or agency. 1267.645 Section 1267.645 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... Executive Office of the President), or any independent regulatory agency....

  16. 14 CFR 1267.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Federal agency or agency. 1267.645 Section 1267.645 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... Executive Office of the President), or any independent regulatory agency....

  17. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  18. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  19. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  20. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  1. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  2. 21 CFR 1404.910 - Agency.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Definitions § 1404.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  3. 21 CFR 1404.910 - Agency.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Definitions § 1404.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  4. 22 CFR 1508.910 - Agency.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Definitions § 1508.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  5. 22 CFR 1508.910 - Agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Definitions § 1508.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  6. 21 CFR 1404.910 - Agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Definitions § 1404.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  7. 31 CFR 19.910 - Agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (NONPROCUREMENT) Definitions § 19.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the...

  8. 21 CFR 1404.910 - Agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Definitions § 1404.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  9. 22 CFR 1508.910 - Agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Definitions § 1508.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  10. 22 CFR 1508.910 - Agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Definitions § 1508.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  11. 22 CFR 208.910 - Agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Definitions § 208.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  12. 31 CFR 19.910 - Agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (NONPROCUREMENT) Definitions § 19.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the...

  13. 22 CFR 1508.910 - Agency.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Definitions § 1508.910 Agency. Agency means any United States executive department, military department, defense agency, or any other agency of the executive branch. Other agencies of the Federal government...

  14. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (northern half), NY (City & State), RI, VT, Puerto Rico and Virgin Islands. Federal Reserve Bank, Pittsburgh... 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  15. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern half... half), LA (northern half), MO, MS (northern half), NE, NM, NV, OK, OR, TN (western half), TX, WA,...

  16. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern half... half), LA (northern half), MO, MS (northern half), NE, NM, NV, OK, OR, TN (western half), TX, WA,...

  17. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern half... half), LA (northern half), MO, MS (northern half), NE, NM, NV, OK, OR, TN (western half), TX, WA,...

  18. Developing Moral Agency through Narrative

    ERIC Educational Resources Information Center

    Pasupathi, Monisha; Wainryb, Cecilia

    2010-01-01

    This paper poses the following question: When, in spite of knowing that it is wrong, people go on to hurt others, what does this mean for the development of moral agency? We begin by defining moral agency and briefly sketching relations between moral agency and other concepts. We then outline what three extant literatures suggest about this…

  19. Paraprofessionals in Public Rehabilitation Agencies.

    ERIC Educational Resources Information Center

    Salomone, Paul R.

    At the outset, social service agencies and numerous public agencies initiated as a result of the Economic Opportunities Act of 1965 were excluded from the scope of this paper. Several subtopics concerning paraprofessionals deserve consideration: (1) the need for paraprofessionals in public rehabilitation agencies; (2) the attitudes of…

  20. Ionization and fragmentation of endohedral fullerenes Ho3N@C80 in an intense femtosecond laser field

    NASA Astrophysics Data System (ADS)

    Xiong, Hui; Fang, Li; Osipov, Timur; Sistrunk, Emily; Wolf, Thomas; Guehr, Markus; Berrah, Nora

    2015-05-01

    Gas phase endohedral fullerenes Ho3N@C80 have been studied by excitation with intense femtosecond laser pulses at 800 nm. Multiple charge states were found after the laser excitation. The highest charge state of the mother molecules was found to be Ho3N@C804+ . The molecules absorb multiple photons during the excitation, and may release extra energy by evaporating multiple C2 dimers from the carbon cage. Ho3N@C70n+ and Ho3N@C50n+ were found to be more stable than other fullerene productions. The molecules may also fragment into Ho+, HoC2+and HoCN+ fragments. The yields of different fragments dependence on laser intensity will be compared to understand the fragmentation pathways. This work is funded by the Department of Energy, Office of Science, Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences under grant N. DE-FG02-92ER14299.A002.

  1. 75 FR 7044 - T&S Hardwoods, Inc., Sylva, NC; Notice of Negative Determination Regarding Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration T&S Hardwoods, Inc., Sylva, NC; Notice of Negative Determination Regarding Application for Reconsideration By application dated January 5, 2010, a petitioner requested administrative reconsideration of the...

  2. Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.

    PubMed

    Xu, Ying; Wu, Dongming; Fan, Yuanchun; Li, Peigeng; Du, Hongfei; Shi, Jiao; Wang, Dan; Zhou, Xiaoping

    2016-01-01

    There are few safe and effective drugs available that protect healthy tissue against radiation-induced damage, highlighting the need to develop such radioprotective agents. We investigated the mechanism underlying the protective effects of the novel, recombinant, flagellin-like protein FlaA N/C against radiation-induced tissue damage in female BALB/c mice. FlaA N/C treatment increased the levels of several pro-proliferative cytokines while inhibiting apoptosis and reducing inflammation. These effects were accompanied by activation of the nuclear factor κB signaling pathway via direct interaction of FlaA N/C with Toll-like receptor 5, as well as enhanced survival of mice after total-body irradiation compared to that observed with treatment with amifostine, a radioprotective agent that is currently being used in clinical practice. These results indicate that FlaA N/C could be further explored as a possible protector of damage to healthy tissue during radiotherapy. PMID:26789847

  3. MODELING TO EVOLVE UNDERSTANDING OF THE SHALLOW GROUND WATER FLOW SYSTEM BENEATH THE LIZZIE RESEARCH SITE, NC

    EPA Science Inventory

    The purpose of the modeling effort presented here is to evolve a conceptual model of ground-water flow at the Lizzie, NC research site using analytic solutions and field observations. The resulting analytic element parameterization of boundary conditions, aquifer transmissivitie...

  4. CHANGES IN HEART RATE VARIABILITY AND LUNG FUNCTION OBSERVED IN NC PATROL TROOPERS EXPOSED TO PM AND AIR TOXICS

    EPA Science Inventory

    Changes in Heart Rate Variability and Lung Function in NC Patrol Troopers exposed to PM and Air Toxics

    Michael Riediker1, Wayne E Cascio1, Robert B Devlin2, Thomas Griggs1&4, Margaret Herbst1, Ronald W Williams3, Steve P McCorquodale4, Philip A Bromberg1
    1) University o...

  5. The Chlorella variabilis NC64A Genome Reveals Adaptation to Photosymbiosis, Coevolution with Viruses, and Cryptic Sex[C][W

    PubMed Central

    Blanc, Guillaume; Duncan, Garry; Agarkova, Irina; Borodovsky, Mark; Gurnon, James; Kuo, Alan; Lindquist, Erika; Lucas, Susan; Pangilinan, Jasmyn; Polle, Juergen; Salamov, Asaf; Terry, Astrid; Yamada, Takashi; Dunigan, David D.; Grigoriev, Igor V.; Claverie, Jean-Michel; Van Etten, James L.

    2010-01-01

    Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes. PMID:20852019

  6. 77 FR 76453 - Opportunity for Designation in Amarillo, TX; Cairo, IL; Baton Rouge, LA; Raleigh, NC; and Belmond...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in Amarillo, TX; Cairo, IL; Baton Rouge, LA; Raleigh, NC; and Belmond, IA Areas; Request for Comments on the...

  7. 76 FR 39155 - R.J. Corman Railroad Property, LLC-Acquisition Exemption-NC Railroad, Inc

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... Register on April 9, 2010 (75 FR 18,253), and became effective on April 25, 2010. On May 28, 2010, RJC... Surface Transportation Board R.J. Corman Railroad Property, LLC--Acquisition Exemption--NC Railroad, Inc R... acquisition transaction is related to the notice of exemption in Docket No. FD 35364, R. J. Corman...

  8. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  9. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  10. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  11. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  12. BARC 2007 EXPERIMENT STATION REPORT FOR NC-229 NATIONAL PROJECT ON PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) CONTROL

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The NC-229 national project “Porcine Reproductive and Respiratory Syndrome (PRRS): Methods for the integrated control, prevention, and elimination of PRRS in United States swine herds.” This station report summarizes the BARC lab’s recent research progress. Four major projects have been addressed. 1...

  13. 76 FR 39298 - Drawbridge Operation Regulation; Cape Fear River, and Northeast Cape Fear River, in Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ..., NC. The deviation restricts the operation of the draw spans to accommodate the 29th Annual Wilmington Family YMCA Tri-Span race. DATES: This deviation is effective from 7 a.m. to 9 a.m. on July 9, 2011... Family YMCA Tri-Span race scheduled for July 9, 2011. The Cape Fear Memorial Bridge is a...

  14. Resonant inelastic light scattering and photoluminescence in isolated nc-Si/SiO{sub 2} quantum dots

    SciTech Connect

    Bairamov, F. B. Toporov, V. V.; Poloskin, E. D.; Bairamov, H.; Roeder, C.; Sprung, C.; Bohmhammel, K.; Seidel, J.; Irmer, G.; Lashkul, A.; Laehderanta, E.; Song, Y. W.

    2013-05-15

    Observation at the room temperature the spectra of the resonant inelastic light scattering by the spatially confined optical phonons as well as the excitonic luminescence caused by confinement effects in the ensemble of isolated quantum dots (QDs) nc-Si/SiO{sub 2} is reported. It is shown that the samples investigated are high purity and high crystalline perfection quality nc-Si/SiO{sub 2} QDs without amorphous phase {alpha}-Si and contaminants. Comparison between the experimental data obtained and phenomenological model of the strong space confinement of optical phonons revealed the need of the more accurate form of the weighted function for the confinement of optical phonons. It is shown that simultaneous detection of the inelastic light scattering by the confinement of phonons and the excitonic luminescence spectra by the confined electron-hole pairs in the nc-Si/SiO{sub 2} QDs allows selfconsistently to determine more accurate values of the diameter of the nc-Si/SiO{sub 2} QDs.

  15. 33 CFR 334.420 - Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Pamlico Sound and adjacent waters... REGULATIONS § 334.420 Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations. (a) Bombing and rocket firing area in Pamlico Sound in vicinity of Brant Island—(1) The area. The...

  16. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  17. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  18. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  19. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  20. 33 CFR 334.420 - Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Pamlico Sound and adjacent waters... REGULATIONS § 334.420 Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations. (a) Bombing and rocket firing area in Pamlico Sound in vicinity of Brant Island—(1) The area. The...

  1. The Chlorella variabilis NC64A Genome Reveals Adaptation to Photosymbiosis, Coevolution with Viruses, and Cryptic Sex

    SciTech Connect

    Blanc, Guillaume; Duncan, Garry A.; Agarakova, Irina; Borodovsky, Mark; Gurnon, James; Kuo, Alan; Lindquist, Erika; Lucas, Susan; Pangailinan, Jasmyn; Polle, Juergen; Salamov, Asaf; Terry, Astrid; Yamada, Takashi; Dunigan, David D.; Grigoriev, Igor V.; Claverie, Jean-Michel; Etten, James L. Van

    2010-05-06

    Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes.

  2. Mean-field theory of baryonic matter for QCD in the large Nc and heavy quark mass limits

    NASA Astrophysics Data System (ADS)

    Adhikari, Prabal; Cohen, Thomas D.

    2013-11-01

    We discuss theoretical issues pertaining to baryonic matter in the combined heavy-quark and large Nc limits of QCD. Witten's classic argument that baryons and interacting systems of baryons can be described in a mean-field approximation with each of the quarks moving in an average potential due to the remaining quarks is heuristic. It is important to justify this heuristic description for the case of baryonic matter since systems of interacting baryons are intrinsically more complicated than single baryons due to the possibility of hidden color states—states in which the subsystems making up the entire baryon crystal are not color-singlet nucleons but rather colorful states coupled together to make a color-singlet state. In this work, we provide a formal justification of this heuristic prescription. In order to do this, we start by taking the heavy quark limit, thus effectively reducing the problem to a many-body quantum mechanical system. This problem can be formulated in terms of integrals over coherent states, which for this problem are simple Slater determinants. We show that for the many-body problem, the support region for these integrals becomes narrow at large Nc, yielding an energy which is well approximated by a single coherent state—that is a mean-field description. Corrections to the energy are of relative order 1/Nc. While hidden color states are present in the exact state of the heavy quark system, they only influence the interaction energy below leading order in 1/Nc.

  3. Capturing the long-sought small-bandgap endohedral fullerene Sc3N@C82 with low kinetic stability.

    PubMed

    Wei, Tao; Wang, Song; Liu, Fupin; Tan, Yuanzhi; Zhu, Xianjun; Xie, Suyuan; Yang, Shangfeng

    2015-03-01

    The long-sought small-bandgap endohedral fullerene Sc3N@C82 with low kinetic stability has been successfully synthesized and isolated for the first time, for which the molecular structure has been unambiguously determined as Sc3N@C82-C2v(39718) by single crystal X-ray diffraction. The C82-C2v(39718) (or labeled as C82-C2v(9) according to the conventional numbering of the isolated pentagon rule (IPR) isomers based on the Fowler-Monolopoulos spiral algorithm) isomeric cage of Sc3N@C82 agrees well with its most stable isomer previously predicted by DFT computations and is dramatically different to those of the reported counterparts M3N@C82-Cs(39663) (M = Gd, Y) based on a non-IPR C82 isomer, revealing the strong dependence of the cage isomeric structure on the size of the encaged metal for C82-based metal nitride clusterfullerenes (NCFs). PMID:25659601

  4. BARC 2009 Annual Report TO NC-1037: Genetic and functional genomic approaches to improve production and quality of pork

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The NC-1037 project addresses “Genetic and functional genomic approaches to improve production and quality of pork.” It has 2 objectives: 1) Further understand the dynamic genetic mechanisms that influence production efficiency and quality of pork; and 2) Discover genetic mechanisms controlling anim...

  5. 77 FR 65856 - Foreign-Trade Subzone 93G-Oxford, NC; Notification of Proposed Production Activity Revlon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... granted subzone authority in 2006 (Board Order 1433, 71 FR 4112, 1/26/06) for the production of certain... Foreign-Trade Zones Board Foreign-Trade Subzone 93G--Oxford, NC; Notification of Proposed Production... Products Corporation (Revlon), operator of Subzone 93G, has submitted a notification of proposed...

  6. 76 FR 61076 - Foreign-Trade Zone 57-Mecklenburg County, NC; Termination of Review of Application for Subzone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... UD shield at the manufacturing facility of FMS Enterprises USA, Inc., located in Lincolnton, North Carolina. The application was filed on February 12, 2009 (74 FR 8904, 2/27/2009). The termination is the... Application for Subzone; FMS Enterprises USA, Inc. (Para- Aramid UD Shield); Lincolnton, NC Notice is...

  7. 40 CFR 721.642 - Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and tetrapropylenepenta-. 721.642 Section 721.642... Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and... substances amines, N-(C14-18 and C16-18 unsaturated alkyl)] dipropylenetri-, (PMN...

  8. 40 CFR 721.642 - Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and tetrapropylenepenta-. 721.642 Section 721.642... Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and... substances amines, N-(C14-18 and C16-18 unsaturated alkyl)] dipropylenetri-, (PMN...

  9. 40 CFR 721.642 - Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and tetrapropylenepenta-. 721.642 Section 721.642... Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and... substances amines, N-(C14-18 and C16-18 unsaturated alkyl)] dipropylenetri-, (PMN...

  10. 40 CFR 721.642 - Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and tetrapropylenepenta-. 721.642 Section 721.642... Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and... substances amines, N-(C14-18 and C16-18 unsaturated alkyl)] dipropylenetri-, (PMN...

  11. 40 CFR 721.642 - Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and tetrapropylenepenta-. 721.642 Section 721.642... Amines, N-(C14-18 and C16-16 unsaturated alkyl)] dipropylene-tri-, tripropylenetetra-, and... substances amines, N-(C14-18 and C16-18 unsaturated alkyl)] dipropylenetri-, (PMN...

  12. Characterization of the high affinity Zn transporter from Noccaea caerulescens, NcZNT1, and dissection of its promoter for its role in Zn uptake and hyperaccumulation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this paper, we conducted a detailed analysis of the ZIP family transporter, NcZNT1, in the Zn/Cd hyperaccumulating plant species, Noccaea caerulescens, formerly known as Thlaspi caerulescens. NcZNT1 was previously suggested to be the primary root Zn/Cd uptake transporter. Both a characterization ...

  13. BARC 2006 station report for NC-1004 national project on Genetic and Functional Genomic Approaches to Improve Production and Quality of Pork

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The NC-1004 national project assesses “Genetic and Functional Genomic Approaches to Improve Production and Quality of Pork.” This final NC-1004 station report summarizes the BARC lab’s recent research progress on the second objective: Discover genetic mechanisms controlling animal health in pork pro...

  14. Construction of an rsmX co-variance model and identification of five rsmX-like ncRNAs in Pseudomonas syringae pv. tomato DC3000

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Non-coding RNAs (ncRNAs) are important components of many regulatory pathways in many Pseudomonad species. In particular, the GacA/S two-component system directly regulates to at least two ncRNAs that act by sequestration of translation repressor proteins to control expression of exproducts. The co...

  15. Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice.

    PubMed

    Taniguchi, Yoshifumi; Kohno, Keizo; Inoue, Shin-ichiro; Koya-Miyata, Satomi; Okamoto, Iwao; Arai, Norie; Iwaki, Kanso; Ikeda, Masao; Kurimoto, Masashi

    2003-09-01

    We have shown previously that in addition to IL-4, IL-5 and IL-10, antigen-specific interferon-gamma (IFN-gamma) production by spleen cells from ovalbumin (OVA)/Alum-immunized mice is inhibited by the administration of royal jelly (RJ). Since it has been shown that both Th1 and Th2 cytokines play pathogenic roles in the generation of atopic dermatitis (AD), we have examined whether RJ suppresses the development of AD-like skin lesions in NC/Nga mice induced by repeated application of picryl chloride (PiCl) under specific pathogen-free (SPF) conditions. Oral administration of RJ to the PiCl-treated NC/Nga mice inhibited the development of AD-like skin lesions in these mice as exemplified by the significant decrease in the total skin severity scores and the decrease in hypertrophy, hyperkeratosis, and infiltration of the epidermis and corium by inflammatory cells. IFN-gamma production by spleen cells from PiCl-treated NC/Nga mice in response to TNP-KLH was partially but significantly inhibited by the oral administration of RJ, while IFN-gamma production by Con A-stimulated spleen cells was not affected. Since inducible nitric oxide (NO) synthase (iNOS)-derived NO has been suggested as an important immunoregulatory mediator in inflammatory autoimmune diseases, we have also examined the expression of iNOS in the dorsal skin lesions of PiCl-treated NC/Nga mice. Interestingly, the expression of iNOS was significantly increased in the skin lesions of RJ-administered mice compared with those of control PBS-administered mice. Thus, our results suggest that RJ suppresses the development of AD-like skin lesions in PiCl-treated NC/Nga mice, possibly by a combination of down-regulating TNP-specific IFN-gamma production and up-regulating iNOS expression. PMID:12890429

  16. Transport and retention of fullerene (nC60) nanoparticles in unsaturated porous media: effects of solution chemistry and solid phase coating.

    PubMed

    Chen, Lixia; Sabatini, David A; Kibbey, Tohren C G

    2012-09-01

    The retention and release of aqueous aggregates of fullerene nanoparticles (nC(60)) were studied under dynamic unsaturated conditions. Porous media containing nC(60) were taken through multiple drainage/imbibition (drying/wetting) cycles to explore the effects of solution conditions and solid surface modification on transport and ultimate fate in unsaturated porous media. In experiments conducted with NaCl as the background electrolyte, the retention of nC(60) during drainage was found to be negligibly small over a wide range of ionic strengths (I=0.2 to I=6 mM), significantly lower than the retention of titanium dioxide nanoparticles studied previously under similar conditions. In contrast, experiments conducted with CaCl(2) as the background electrolyte found that retention of nC(60) during drainage was significant at higher ionic strengths, particularly at the highest ionic strength studied (I=6 mM). Experiments examining the influence of dissolved natural organic matter on nC(60) retention in unsaturated media found no measurable impact on the transport. The effects of solid surface modification were examined by creating coatings that modified surface hydrophobicity and charge. Experiments found that a hydrophobic coating had no measurable impact on nC(60) retention, when compared with retention by unmodified media. In contrast, a porous medium with surfaces that were both hydrophobic and positively-charged retained 5-10 times more nC(60) during drainage than an unmodified porous medium. This result suggests that electrostatic interactions play a more important role than hydrophobic interactions in the transport and fate of nC(60) in the unsaturated zone. For all conditions where retention was observed, experiments found very little release or retained nC(60) after subsequent flushing with water, suggesting that once retained, the environmental mobility of nC(60) may be extremely limited. PMID:22858671

  17. Neuromodulation, agency and autonomy.

    PubMed

    Glannon, Walter

    2014-01-01

    Neuromodulation consists in altering brain activity to restore mental and physical functions in individuals with neuropsychiatric disorders and brain and spinal cord injuries. This can be achieved by delivering electrical stimulation that excites or inhibits neural tissue, by using electrical signals in the brain to move computer cursors or robotic arms, or by displaying brain activity to subjects who regulate that activity by their own responses to it. As enabling prostheses, deep-brain stimulation and brain-computer interfaces (BCIs) are forms of extended embodiment that become integrated into the individual's conception of himself as an autonomous agent. In BCIs and neurofeedback, the success or failure of the techniques depends on the interaction between the learner and the trainer. The restoration of agency and autonomy through neuromodulation thus involves neurophysiological, psychological and social factors. PMID:23322211

  18. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers.

    PubMed

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J; Wasiluk, Andrew; Heidet, Laurence; Kitching, A Richard; Borza, Dorin-Bogdan

    2013-02-15

    Goodpasture disease is an autoimmune kidney disease mediated by autoantibodies against noncollagenous domain 1 (NC1) monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis (GN). We identified a novel type of human IgG4-restricted anti-GBM autoantibodies associated with mild nonprogressive GN, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoantibodies were investigated in mouse models recapitulating this phenotype. Wild-type and FcγRIIB(-/-) mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoantibodies specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause GN. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3(-/-) Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG Abs specific for α345NC1 hexamers, which were not subclass restricted. As heterologous Ag in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a, and IgG2b autoantibodies specific for α345NC1 hexamers and induced anti-GBM Ab GN. These findings indicate that tolerance toward autologous intact α345(IV) collagen is established in hosts expressing this Ag, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α345NC1 hexamers. This provides a mechanism eliciting autoantibodies specific for α345NC1 hexamers, which are restricted to noninflammatory IgG subclasses and are nonnephritogenic. In Alport syndrome, lack of tolerance toward α345(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including proinflammatory IgG subclasses that mediate posttransplant anti-GBM nephritis. PMID:23303673

  19. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

    PubMed Central

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J.; Wasiluk, Andrew; Heidet, Laurence; Kitching, A. Richard; Borza, Dorin-Bogdan

    2012-01-01

    Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated with mild non-progressive glomerulonephritis, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoAbs were investigated in mouse models recapitulating this phenotype. Wild type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoAbs specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause glomerulonephritis. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG antibodies specific for α3α4α5NC1 hexamers, which were not subclass restricted. As heterologous antigen in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a and IgG2b autoAbs specific for α345NC1 hexamers and induced anti-GBM Ab glomerulonephritis. These findings indicate that tolerance toward autologous intact α3α4α5(IV) collagen is established in hosts expressing this antigen, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α3α4α5NC1 hexamers. This provides a mechanism eliciting autoAbs specific for α345NC1 hexamers, which are restricted to non-inflammatory IgG subclasses and non-nephritogenic. In Alport syndrome, lack of tolerance toward α3α4α5(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including pro-inflammatory IgG subclasses which mediate post-transplant anti-GBM nephritis. PMID:23303673

  20. Forging Hispanic communities in new destinations: A case study of Durham, NC1

    PubMed Central

    Flippen, Chenoa A.; Parrado, Emilio A.

    2013-01-01

    The Chicago School of urban sociology and its extension in the spatial assimilation model have provided the dominant framework for understanding the interplay between immigrant social and spatial mobility. However, the main tenets of the theory were derived from the experience of pre-war, centralized cities; scholars falling under the umbrella of the Los Angeles school have recently challenged the extent to which they are applicable to the contemporary urban form, which is characterized by sprawling, decentralized, and multi-nucleated development. Indeed, new immigrant destinations, such as those scattered throughout the American Southeast, are both decentralized and lack prior experience with large scale immigration. Informed by this debate this paper traces the formation and early evolution of Hispanic neighborhoods in Durham, NC, a new immigrant destination. Using qualitative data we construct a social history of immigrant neighborhoods and apply survey and census information to examine the spatial pattern of neighborhood succession. We also model the sorting of immigrants across neighborhoods according to personal characteristics. Despite the many differences in urban form and experience with immigration, the main processes forging the early development of Hispanic neighborhoods in Durham are remarkably consistent with the spatial expectations from the Chicago School, though the sorting of immigrants across neighborhoods is more closely connected to family dynamics and political economy considerations than purely human capital attributes. PMID:24482612

  1. Neutrino-Nucleus Coherent NC({pi}{sup 0}) Scattering in the MINOS Near Detector

    SciTech Connect

    Cherdack, Daniel

    2011-11-23

    Neutrino reactions recorded by the MINOS Near Detector in exposures totalling 2.8x10{sup 20} protons-on-target were searched for single, highly-forward {pi}{sup 0} mesons produced by coherent neutral current interactions {nu}{sub {mu}}+A{yields}{nu}{sub {mu}}+A+{pi}{sup 0}. Events having topologies consistent with single electromagnetic showers were isolated. Contributions from neutrino-induced backgrounds are determined using a data-driven fit of Monte Carlo distributions over sideband regions. The fit is used to project the background levels into signal regions. An excess of events above the best-fit background is observed for shower topologies of few GeV energies and at very forward angles. The partial cross section for NC({pi}{sup 0}) coherent scattering yielding E{sub vis}({pi}{sup 0})>1.0 GeV averaged over incident neutrino energies 2.4{<=}E{sub {nu}{<=}9}.0 GeV is (31.6{+-}10.5)x10{sup -40} cm{sup 2}/nucleus. Total cross sections for coherent scattering from nuclei of average nucleon number A{sub eff} = 48 and for iron (A = 56) nuclei are estimated for } = 4.9 GeV.

  2. Kinetics of Extracellular Peptidases in Sediments of the White Oak River, NC, USA

    NASA Astrophysics Data System (ADS)

    Steen, A. D.; Kevorkian, R. T.; Alperin, M. J.; Lloyd, K. G.

    2013-12-01

    Recent molecular work has shed light on the mechanisms underlying organoheterotrophy in the marine subsurface, including production of extracellular peptidases by deeply-branching Archaea. Here we present measurements of the potential activity (Vmax) and half-saturation constants (Km) for six extracellular peptidase substrates in sediments from 0 to 83 cm deep in the White Oak River estuary, NC, USA. Potential activities at 83 cm were on average 12% of the values at the surface, but because surface Vmax values were several orders of magnitude greater than comparable values from surface seawater, the deep activities were still substantial. Km values did not display a clear trend with depth. Activities consistent with leucyl aminopeptidase were higher than any other extracellular peptidase, but there was no clear division in activities between endopeptidases (which cleave bonds in the interior of proteins) versus aminopeptidases (which cleave N-terminal amino acids). Competitive inhibition experiments will reveal the extent to which the activities we measured reflect the distinct enzymes. We will also present model-based estimates of organic carbon mineralization rates based on methane and sulfate profiles in order to assess the relative importance of extracellular peptidases as a means to acquire organic carbon in the subsurface. Saturation curves for 5 peptidase substrates at the surface and 83 cm in the White Oak River.

  3. The infrared fundamental intensities and polar tensor of CH 3NC

    NASA Astrophysics Data System (ADS)

    Haiduke, R. L. A.; Hase, Y.; Bruns, R. E.

    2003-01-01

    The molecular force field and polar tensor of methyl isocyanide have been determined from its gas phase vibrational frequencies and infrared intensities. Quantum chemical results from MP2(FC), B3LYP and quadratic configuration interaction calculation including single and double substitutions procedures using a 6-311++G(3d,3p) basis set have been used to determine the signs of the dipole moment derivatives with respect to the normal coordinates as well as estimate individual fundamental intensities of the overlapped vl- v5 and v3- v6 band systems. Principal component graphical representations of the A1 and E symmetry polar tensor elements were useful in determining preferred sets of tensor elements. The mean dipole moment derivative (GAPT charge) of the methyl carbon in CH 3NC, 0.347 e, is between the corresponding values in CH 3CN, 0.110 e, and CH 3F, 0.541 e. The mean dipole moment derivatives obtained here indicate the correct 1s methyl carbon ionization energy as 293.35 eV which is 0.98 eV higher than the corresponding ionization energy of the terminal atom.

  4. Criticality Detection Using a Mirion Technologies DRM-2NC Remote Area Monitor Geiger-Mueller Probe

    NASA Astrophysics Data System (ADS)

    Kryskow, Adam P.

    The prompt fission neutron activation and subsequent response of a DRM-2NC Geiger-Mueller probe (manufactured by Mirion Technologies) was investigated for the purpose of creating a criticality accident detection algorithm with sensitivity and false positive suppression comparable to modern criticality accident detection systems. The expected decay pattern of secondary emissions arising from the neutron induced activity of the Geiger-Mueller probe was investigated experimentally in high neutron fluence environments at research reactors operated by the University of Massachusetts Lowell, Pennsylvania State University, and the White Sands Missile Range of Los Alamos National Laboratory. Monte Carlo techniques were used to both identify key probe materials responsible for the majority of the Geiger-Mueller response and investigate the effects of boron doping to increase detector sensitivity and enhance the signal to noise ratio. Subsequently, a statistical algorithm centered on a point weighted linear regression of the combined effective half-life was developed as the basis for criticality declaration. Final testing of the system indicated that the system was capable of meeting all ANSI criticality accident criteria with sufficient sensitivity to the minimum accident of concern, an adequate response time, and an extremely low likelihood of false alarm.

  5. Preliminary Estimates of Specific Discharge and TransportVelocities near Borehole NC-EWDP-24PB

    SciTech Connect

    Freifeld, Barry; Doughty, Christine; Finsterle, Stefan

    2006-06-21

    This report summarizes fluid electrical conductivity (FEC)and thermal logging data collected in Borehole NC-EWDP-24PB, locatedapproximately 15 km south of the proposed repository at Yucca Mountain.Preliminary analyses of a small fraction of the FEC and temperature dataindicate that relatively large, localized fluid fluxes are likely toexist at this location. The implication that considerable flow is inducedby small gradients, and that flow is highly localized, is significant forthe estimation of groundwater transport velocities and radionuclidetravel times. The sensitivity of the data to potential perturbationsduring testing (i.e., internal wellbore flow in the case of FEC data, andbuoyancy effects in the case of thermal logging data) make it difficultto conclusively derive fluid fluxes and transport velocities without adetailed analysis of all data and processes involved. Such acomprehensive analysis has not yet been performed. However, thepreliminary results suggest that the ambient component of the estimatedflow rates is significant and on the order of liters per minute, yieldinggroundwater transport velocities in the range of kilometers per year. Oneparticular zone in the Bullfrog tuff exhibits estimated velocities on theorder of 10 km/yr. Given that the preliminary estimates of ambient flowrates and transport velocities are relatively high, and considering thepotential impact of high rates and velocities on saturated-zone flow andtransport behavior, we recommend that a comprehensive analysis of all theavailable data be performed. Moreover, additional data sets at otherlocations should be collected to examine whether the current data set isrepresentative of the regional flow system near YuccaMountain.

  6. Forging Hispanic communities in new destinations: A case study of Durham, NC.

    PubMed

    Flippen, Chenoa A; Parrado, Emilio A

    2012-03-01

    The Chicago School of urban sociology and its extension in the spatial assimilation model have provided the dominant framework for understanding the interplay between immigrant social and spatial mobility. However, the main tenets of the theory were derived from the experience of pre-war, centralized cities; scholars falling under the umbrella of the Los Angeles school have recently challenged the extent to which they are applicable to the contemporary urban form, which is characterized by sprawling, decentralized, and multi-nucleated development. Indeed, new immigrant destinations, such as those scattered throughout the American Southeast, are both decentralized and lack prior experience with large scale immigration. Informed by this debate this paper traces the formation and early evolution of Hispanic neighborhoods in Durham, NC, a new immigrant destination. Using qualitative data we construct a social history of immigrant neighborhoods and apply survey and census information to examine the spatial pattern of neighborhood succession. We also model the sorting of immigrants across neighborhoods according to personal characteristics. Despite the many differences in urban form and experience with immigration, the main processes forging the early development of Hispanic neighborhoods in Durham are remarkably consistent with the spatial expectations from the Chicago School, though the sorting of immigrants across neighborhoods is more closely connected to family dynamics and political economy considerations than purely human capital attributes. PMID:24482612

  7. 14 CFR 73.15 - Using agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and the controlling agency, under which the using agency would notify the controlling agency whenever the controlling agency may grant permission for transit through the restricted area in accordance...

  8. 14 CFR 73.15 - Using agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and the controlling agency, under which the using agency would notify the controlling agency whenever the controlling agency may grant permission for transit through the restricted area in accordance...

  9. 77 FR 18799 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    .... Environmental Protection Agency (EPA) sponsored questions related to water use on the 2007 CBECS. The water.... Energy Information Administration Proposed Agency Information Collection AGENCY: U.S. Energy Information Administration (EIA), Department of Energy (DOE). ACTION: Agency Information Collection Activities:...

  10. Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC

    PubMed Central

    Bazzi, Ali; Zargarian, Loussiné; Chaminade, Françoise; Boudier, Christian; De Rocquigny, Hughes; René, Brigitte; Mély, Yves; Fossé, Philippe; Mauffret, Olivier

    2011-01-01

    An essential step of the reverse transcription of the HIV-1 genome is the first strand transfer that requires the annealing of the TAR RNA hairpin to the cTAR DNA hairpin. HIV-1 nucleocapsid protein (NC) plays a crucial role by facilitating annealing of the complementary hairpins. Using nuclear magnetic resonance and gel retardation assays, we investigated the interaction between NC and the top half of the cTAR DNA (mini-cTAR). We show that NC(11-55) binds the TGG sequence in the lower stem that is destabilized by the adjacent internal loop. The 5′ thymine interacts with residues of the N-terminal zinc knuckle and the 3′ guanine is inserted in the hydrophobic plateau of the C-terminal zinc knuckle. The TGG sequence is preferred relative to the apical and internal loops containing unpaired guanines. Investigation of the DNA–protein contacts shows the major role of hydrophobic interactions involving nucleobases and deoxyribose sugars. A similar network of hydrophobic contacts is observed in the published NC:DNA complexes, whereas NC contacts ribose differently in NC:RNA complexes. We propose that the binding polarity of NC is related to these contacts that could be responsible for the preferential binding to single-stranded nucleic acids. PMID:21227929

  11. Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.

    PubMed

    Bazzi, Ali; Zargarian, Loussiné; Chaminade, Françoise; Boudier, Christian; De Rocquigny, Hughes; René, Brigitte; Mély, Yves; Fossé, Philippe; Mauffret, Olivier

    2011-05-01

    An essential step of the reverse transcription of the HIV-1 genome is the first strand transfer that requires the annealing of the TAR RNA hairpin to the cTAR DNA hairpin. HIV-1 nucleocapsid protein (NC) plays a crucial role by facilitating annealing of the complementary hairpins. Using nuclear magnetic resonance and gel retardation assays, we investigated the interaction between NC and the top half of the cTAR DNA (mini-cTAR). We show that NC(11-55) binds the TGG sequence in the lower stem that is destabilized by the adjacent internal loop. The 5' thymine interacts with residues of the N-terminal zinc knuckle and the 3' guanine is inserted in the hydrophobic plateau of the C-terminal zinc knuckle. The TGG sequence is preferred relative to the apical and internal loops containing unpaired guanines. Investigation of the DNA-protein contacts shows the major role of hydrophobic interactions involving nucleobases and deoxyribose sugars. A similar network of hydrophobic contacts is observed in the published NC:DNA complexes, whereas NC contacts ribose differently in NC:RNA complexes. We propose that the binding polarity of NC is related to these contacts that could be responsible for the preferential binding to single-stranded nucleic acids. PMID:21227929

  12. Effect of nitrogen dioxide on the EPR property of lithium octa-n-butoxy 2,3-naphthalocyanine (LiNc-BuO) microcrystals.

    PubMed

    Pandian, Ramasamy P; Dang, Vinh; Manoharan, Periakaruppan T; Zweier, Jay L; Kuppusamy, Periannan

    2006-07-01

    Lithium octa-n-butoxy-naphthalocyanine (LiNc-BuO) is a stable free radical that can be detected by electron paramagnetic resonance (EPR) spectroscopy. Previously we have reported that microcrystals of LiNc-BuO exhibit a single sharp EPR peak, whose width varies linearly with the partial pressure of paramagnetic molecules such as oxygen and nitric oxide. In this report, we present the effect of nitrogen dioxide (NO2), which is also a paramagnetic molecule, on the EPR properties of LiNc-BuO. The gas-sensing property of LiNc-BuO is attributed to the open molecular framework of the crystal structure which is arranged with wide channels capable of accommodating large molecules such as NO2. The EPR linewidth of LiNc-BuO was highly sensitive to the partial pressure of NO2 in the gas mixture. The line-broadening was quick and reversible in the short-term for low concentration of NO2. However, the EPR signal intensity decreased with time of exposure, apparently due to a reaction of NO2 with LiNc-BuO crystals to give diamagnetic products. The results suggested that LiNc-BuO may be a useful probe for the determination of trace amounts of NO2 using EPR spectroscopy. PMID:16690337

  13. Interacting genes that affect microtubule function in Drosophila melanogaster: Two classes of mutation revert the failure to complement between hay sup nc2 and mutations in tubulin genes

    SciTech Connect

    Regan, C.L.; Fuller, M.T. )

    1990-05-01

    The recessive male sterile mutation hay{sup nc2} of Drosophila melanogaster fails to complement certain {beta}{sub 2}-tubulin and {alpha}-tubulin mutations, suggesting that the haywire product plays a role in microtubule function, perhaps as a structural component of microtubules. The genetic interaction appears to require the presence of the aberrant product encoded by hay{sup nc2}, which may act as a structural poison. Based on this observation, the authors have isolated ten new mutations with EMS that revert the failure to complement between hay{sup nc2} and B2t{sup n}. The revertants tested behaved as intragenic mutations of hay in recombination tests, and feel into two phenotypic classes, suggesting two functional domains of the hay gene product. Some revertants were hemizygous viable and less severe than hay{sup nc2} in their recessive phenotype. These mutations might revert the poison by restoring the aberrant product encoded by the hay{sup nc2} allele to more wild-type function. Most of the revertants were recessive lethal mutations, indicating that the hay gene product is essential for viability. These more extreme mutations could revert the poison by destroying the ability of the aberrant haywire{sup nc2} product to interact structurally with microtubules. Flies heterozygous for the original hay{sup nc2} allele and an extreme revertant show defects in both the structure and the function of the male meiotic spindle.

  14. 45 CFR 1173.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Federal agency or agency. 1173.645 Section 1173.645 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES GOVERNMENTWIDE REQUIREMENTS FOR...

  15. 45 CFR 1155.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Federal agency or agency. 1155.645 Section 1155.645 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE...

  16. Inhibition of Elastin Peptide-Mediated Angiogenic Signaling Mechanism(s) in Choroidal Endothelial Cells by the α6(IV)NC1 Collagen Fragment

    PubMed Central

    Gunda, Venugopal; Verma, Raj Kumar; Sudhakar, Yakkanti Akul

    2013-01-01

    Purpose. The inhibitory effects and mechanism(s) of type IV collagen α-6 chain–derived noncollagenous domain (α6[IV]NC1 or hexastatin) on elastin-derived peptide (EDP)–activated choroidal endothelial cell migration, kinase signaling, and membrane type 1 metalloproteinase (MT1-MMP) activation are explored. Methods. Mouse choroidal endothelial cells (MCECs) were incubated in media with soluble EDPs (kappa elastin, mouse elastin, and Val-Gly-Val-Ala-Pro-Gly [VGVAPG] hexapeptide) for different time intervals with or without α6(IV)NC1. The MCECs proliferation, migration, tube formation, MT1-MMP expression, and angiogenic signaling were analyzed in cells subjected to EDP and α6(IV)NC1 treatments. The MCECs also were subjected to EDPs, and specific inhibitors for evaluation of focal adhesion kinase (FAK) and protein kinase B (Akt) phosphorylation. Results. Kappa elastin, mouse elastin, and VGVAPG enhanced the migration, without affecting the proliferation of MCECs. The α6(IV)NC1 inhibited survival and EDP-activated migration of MCECs. The EDP-activated MCEC tube formation on matrigel also was inhibited by α6(IV)NC1. Further, EDP-activated MT1-MMP expression and FAK/phosphoinositide-3-kinase (PI-3K)/mammalian target of rapamycin (mToR)/Akt phosphorylation in MCECs, were reduced by α6(IV)NC1. The EDP-induced FAK and Akt phosphorylation was blocked by FAK- and Akt-specific inhibitors. Conclusions. The EDPs and α6(IV)NC1 are identified to exhibit opposing effects on MCEC angiogenic behavior and signaling. The α6(IV)NC1 inhibited cell survival, EDP-mediated migration, MT1-MMP expression and, FAK/PI-3K/mToR/Akt phosphorylation in MCECs. This work demonstrates α6(IV)NC1 as a prospective endogenous molecule for the treatment of diseases involving choroidal neovascularization in the eye. PMID:24194191

  17. Detachment of fullerene nC60 nanoparticles in saturated porous media under flow/stop-flow conditions: Column experiments and mechanistic explanations.

    PubMed

    Wang, Zhan; Wang, Dengjun; Li, Baoguo; Wang, Jizhong; Li, Tiantian; Zhang, Mengjia; Huang, Yuanfang; Shen, Chongyang

    2016-06-01

    This study was aimed at investigating the detachment of fullerene nC60 nanoparticles (NPs) in saturated sand porous media under transient and static conditions. The nC60 NPs were first attached at primary minima of Derjaguin-Landau-Verwey-Overbeek (DLVO) interaction energy profiles in electrolyte solutions with different ionic strengths (ISs). The columns were then eluted with deionized water to initiate nC60 NP detachment by decreasing solution IS. Finally, the flow of the columns was periodically interrupted to investigate nC60 NP detachment under static condition. Our results show that the detachment of nC60 NPs occurred under both transient and static conditions. The detachment under transient conditions was attributed to the fact that the attractions acting on the nC60 NPs at primary minima were weakened by nanoscale physical heterogeneities and overcome by hydrodynamic drags at lower ISs. However, a fraction of nC60 NPs remained at shallow primary minima in low flow regions, and detached via Brownian diffusion during flow interruptions. Greater detachment of nC60 NPs occurred under both transient and static conditions if the NPs were initially retained in electrolyte solutions with lower valent cations due to lower attractions between the NPs and collectors. Decrease in collector surface chemical heterogeneities and addition of dissolved organic matter also increased the extent of detachment by increasing electrostatic and steric repulsions, respectively. While particle attachment in and subsequent detachment from secondary minima occur in the same electrolyte solution, our results indicate that perturbation in solution chemistry is necessary to lower the primary minimum depths to initiate spontaneous detachment from the primary minima. These findings have important implications for predicting the fate and transport of nC60 NPs in subsurface environments during multiple rainfall events and accordingly for accurately assessing their environmental risks. PMID

  18. The Y3** ncRNA promotes the 3′ end processing of histone mRNAs

    PubMed Central

    Köhn, Marcel; Ihling, Christian; Sinz, Andrea; Krohn, Knut; Hüttelmaier, Stefan

    2015-01-01

    We demonstrate that the Y3/Y3** noncoding RNAs (ncRNAs) bind to the CPSF (cleavage and polyadenylation specificity factor) and that Y3** associates with the 3′ untranslated region (UTR) of histone pre-mRNAs. The depletion of Y3** impairs the 3′ end processing of histone pre-mRNAs as well as the formation and protein dynamics of histone locus bodies (HLBs), the site of histone mRNA synthesis and processing. HLB morphology is also disturbed by knockdown of the CPSF but not the U7-snRNP components. In conclusion, we propose that the Y3** ncRNA promotes the 3′ end processing of histone pre-mRNAs by enhancing the recruitment of the CPSF to histone pre-mRNAs at HLBs. PMID:26443846

  19. PREFACE: NC-AFM 2004: Proceedings of the 7th International Conference on Non-contact Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Schwarz, Udo

    2005-03-01

    With the ongoing miniaturization of devices and controlled nanostructuring of materials, the importance of atomic-scale information on surfaces and surface properties is growing continuously. The astonishing progress in nanoscience and nanotechnology that took place during the last two decades was in many ways related to recent progress in high-resolution imaging techniques such as scanning tunnelling microscopy and transmission electron microscopy. Since the mid-1990s, non-contact atomic force microscopy (NC-AFM) performed in ultrahigh vacuum has evolved as an alternative technique that achieves atomic resolution, but without the restriction to conducting surfaces of the previously established techniques. Advances of the rapidly developing field of NC-AFM are discussed at annual conferences as part of a series that started in 1998 in Osaka, Japan. This special issue of Nanotechnology is a compilation of original work presented at the 7th International Conference on Non-contact Atomic Force Microscopy that took place in Seattle, USA, 12-15 September 2004. Over the years, the conference grew in size and scope. Atomic resolution imaging of oxides and semiconductors remains an issue. Noticeable new developments have been presented in this regard such as, e.g., the demonstrated ability to manipulate individual atoms. Additionally, the investigation of individual molecules, clusters, and organic materials gains more and more attention. In this context, considerable effort is undertaken to transfer the NC-AFM principle based on frequency modulation to applications in air and liquids with the goal of enabling high-resolution surface studies of biological material in native environments, as well as to reduce the experimental complexity, which so far involves the availability of (costly) vacuum systems. Force spectroscopy methods continue to be improved and are applied to topics such as the imaging of the three-dimensional force field as a function of the distance with

  20. Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice.

    PubMed

    Park, Hyeon Soo; Hwang, Yong Hyeon; Kim, Mun Ki; Hong, Gyeong Eun; Lee, Ho Jeong; Nagappan, Arulkumar; Yumnam, Silvia; Kim, Eun Hee; Heo, Jeong Doo; Lee, Sang Joon; Won, Chung Kil; Kim, Gon Sup

    2015-01-01

    Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2,4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent. PMID:25248662