Science.gov

Sample records for agency rtp nc

  1. PARTICLE SIZE DISTRIBUTIONS FROM SELECT RESIDENCES PARTICIPATING IN THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    Particle Size Distributions from Select Residences Participating in the NERL RTP PM Panel Study. Alan Vette, Ronald Williams, and Michael Riediker, U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, NC 27711; Jonathan Thornburg...

  2. RTP Speakers Bureau

    EPA Pesticide Factsheets

    The Research Triangle Park Speakers Bureau page is a free resource that schools, universities, and community groups in the Raleigh-Durham-Chapel Hill, N.C. area can use to request speakers and find educational resources.

  3. STATUS OF THE U.S. ENVIRONMENTAL PROTECTION AGENCY'S ENCODRINE DISRUPTOR SCREENING PROGRAM

    EPA Science Inventory

    Status of the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program. Susan Laws. Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. EPA, RTP, NC.

    In response to emergi...

  4. EPA/ORD/RTP (Environmental Protection Agency, Office of Research and Development, Research Triangle Park) asbestos program support for the OTS (Office of Toxic Substances) asbestos-in-schools program. Final report

    SciTech Connect

    Beard, M.E.

    1986-03-01

    An overview of the EPA/ORD/RTP Asbestos program support for the OTS Asbestos-in-Schools Program is given. The program includes (1) a bulk sample asbestos analysis audit program, (2) an intercomparison of three measurement methods for airborne asbestos, (3) the development of audit materials for airborne asbestos measurement methods, and (4) the development of guidance for post-abatement asbestos air monitoring.

  5. Plasma filamentation in the Rijnhuizen tokamak RTP

    SciTech Connect

    Lopes Cardozo, N.J.; Schueller, F.C.; Barth, C.J.; Chu, C.C.; Pijper, F.J.; Lok, J.; Oomens, A.A.M. )

    1994-07-11

    Evidence for small scale magnetic structures in the Rijnhuizen tokamak RTP is presented. These are manifest through steps and peaks in the electron temperature and pressure, measured with multiposition Thomson scattering. During central electron cyclotron heating, several filaments of high pressure are found in the power deposition region. They live hundreds of microseconds. Near the sawtooth inversion radius a step'' in the temperature profile occurs. Further out, quasiperiodic structures are observed, in both Ohmic and heated discharges.

  6. Double pulse Thomson scattering system at RTP

    SciTech Connect

    Beurskens, M.N.; Barth, C.J.; Chu, C.C.; Donne, A.J.; Herranz, J.A.; Lopes Cardozo, N.J.; van der Meiden, H.J.; Pijper, F.J.

    1997-01-01

    In this article a double pulse multiposition Thomson scattering diagnostic, under construction at RTP, is discussed. Light from a double pulsed ruby laser (pulse separation: 10{endash}800 {mu}s, max. 2{times}12.5 J) is scattered by the free electrons of the tokamak plasma and relayed to a Littrow polychromator for spectral analysis. The spectrally resolved light is recorded by two ICCD detectors. Simulations show that the system sensitivity will be such that electron temperatures in the range of 100 eV{endash}7 keV can be determined with an accuracy as good as 2{percent}{endash}3{percent} for electron densities of 10{sup 20} m{sup {minus}3}, with a spatial resolution down to 2.6 mm. With this diagnostic the dynamics of small scale structures in the electron temperature profile will be studied. {copyright} {ital 1997 American Institute of Physics.}

  7. The characteristic assessment of spent ion exchange resin from PUSPATI TRIGA REACTOR (RTP) for immobilization process

    SciTech Connect

    Wahida, Nurul; Yasir, Muhamad Samudi; Majid, Amran Ab; Irwan, M. N.; Wahab, Mohd Abd; Marzukee, Nik; Paulus, Wilfred; Phillip, Esther; Thanaletchumy

    2014-09-03

    In this paper, spent ion exchange resin generated from PUSPATI TRIGA reactor (RTP) in Malaysian Nuclear Agency were characterized based on the water content, radionuclide content and radionuclide leachability. The result revealed that the water content in the spent resin is 48%. Gamma spectrometry analysis indicated the presence of {sup 134}Cs, {sup 137}Cs, {sup 152}Eu, {sup 54}Mn, {sup 58}Co, {sup 60}Co and {sup 65}Zn. The leachability test shows a small concentrations (<1 Bq/l) of {sup 152}Eu and {sup 134}Cs were leached out from the spent resin while {sup 60}Co activity concentrations slightly exceeded the limit generally used for industrial wastewater i.e. 1 Bq/l. Characterization of spent ion exchange resin sampled from RTP show that this characterization is important as a basis to immobilize this radioactive waste using geopolymer technology.

  8. The characteristic assessment of spent ion exchange resin from PUSPATI TRIGA REACTOR (RTP) for immobilization process

    NASA Astrophysics Data System (ADS)

    Wahida, Nurul; Yasir, Muhamad Samudi; Majid, Amran Ab; Wahab, Mohd Abd; Marzukee, Nik; Paulus, Wilfred; Phillip, Esther; Thanaletchumy, Irwan, M. N.

    2014-09-01

    In this paper, spent ion exchange resin generated from PUSPATI TRIGA reactor (RTP) in Malaysian Nuclear Agency were characterized based on the water content, radionuclide content and radionuclide leachability. The result revealed that the water content in the spent resin is 48%. Gamma spectrometry analysis indicated the presence of 134Cs, 137Cs, 152Eu, 54Mn, 58Co, 60Co and 65Zn. The leachability test shows a small concentrations (<1 Bq/l) of 152Eu and 134Cs were leached out from the spent resin while 60Co activity concentrations slightly exceeded the limit generally used for industrial wastewater i.e. 1 Bq/l. Characterization of spent ion exchange resin sampled from RTP show that this characterization is important as a basis to immobilize this radioactive waste using geopolymer technology.

  9. Airborne ocean water lidar (OWL) real time processor (RTP)

    NASA Astrophysics Data System (ADS)

    Hryszko, M.

    1995-03-01

    The Hyperflo Real Time Processor (RTP) was developed by Pacific-Sierra Research Corporation as a part of the Naval Air Warfare Center's Ocean Water Lidar (OWL) system. The RTP was used for real time support of open ocean field tests at Barbers Point, Hawaii, in March 1993 (EMERALD I field test), and Jacksonville, Florida, in July 1994 (EMERALD I field test). This report describes the system configuration, and accomplishments associated with the preparation and execution of these exercises. This document is intended to supplement the overall test reports and provide insight into the development and use of the PTP. A secondary objective is to provide basic information on the capabilities, versatility and expandability of the Hyperflo RTP for possible future projects. It is assumed herein that the reader has knowledge of the OWL system, field test operations, general lidar processing methods, and basic computer architecture.

  10. Neutron flux and power in RTP core-15

    SciTech Connect

    Rabir, Mohamad Hairie Zin, Muhammad Rawi Md; Usang, Mark Dennis; Bayar, Abi Muttaqin Jalal; Hamzah, Na’im Syauqi Bin

    2016-01-22

    PUSPATI TRIGA Reactor achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. This paper describes the reactor parameters calculation for the PUSPATI TRIGA REACTOR (RTP); focusing on the application of the developed reactor 3D model for criticality calculation, analysis of power and neutron flux distribution of TRIGA core. The 3D continuous energy Monte Carlo code MCNP was used to develop a versatile and accurate full model of the TRIGA reactor. The model represents in detailed all important components of the core with literally no physical approximation. The consistency and accuracy of the developed RTP MCNP model was established by comparing calculations to the available experimental results and TRIGLAV code calculation.

  11. Neutron flux and power in RTP core-15

    NASA Astrophysics Data System (ADS)

    Rabir, Mohamad Hairie; Zin, Muhammad Rawi Md; Usang, Mark Dennis; Bayar, Abi Muttaqin Jalal; Hamzah, Na'im Syauqi Bin

    2016-01-01

    PUSPATI TRIGA Reactor achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. This paper describes the reactor parameters calculation for the PUSPATI TRIGA REACTOR (RTP); focusing on the application of the developed reactor 3D model for criticality calculation, analysis of power and neutron flux distribution of TRIGA core. The 3D continuous energy Monte Carlo code MCNP was used to develop a versatile and accurate full model of the TRIGA reactor. The model represents in detailed all important components of the core with literally no physical approximation. The consistency and accuracy of the developed RTP MCNP model was established by comparing calculations to the available experimental results and TRIGLAV code calculation.

  12. COARSE PARTICULATE MATTER CONCENTRATIONS FROM RESIDENTIAL OUTDOOR SITES ASSOCIATED WITH THE NORTH CAROLINA ASTHMA AND CHILDREN'S ENVIRONMENT STUDIES (NC - ACES)

    EPA Science Inventory

    Residential outdoor monitoring was performed at 26 homes in the RTP area of NC from September 2003 to June 2004. PM10-2.5 values were estimated using the differential between independent PM10 and PM2.5 collocated MiniVol measurements. The dichot...

  13. Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease

    PubMed Central

    Romaní-Aumedes, J; Canal, M; Martín-Flores, N; Sun, X; Pérez-Fernández, V; Wewering, S; Fernández-Santiago, R; Ezquerra, M; Pont-Sunyer, C; Lafuente, A; Alberch, J; Luebbert, H; Tolosa, E; Levy, O A; Greene, L A; Malagelada, C

    2014-01-01

    Mutations in the PARK2 gene are associated with an autosomal recessive form of juvenile parkinsonism (AR-JP). These mutations affect parkin solubility and impair its E3 ligase activity, leading to a toxic accumulation of proteins within susceptible neurons that results in a slow but progressive neuronal degeneration and cell death. Here, we report that RTP801/REDD1, a pro-apoptotic negative regulator of survival kinases mTOR and Akt, is one of such parkin substrates. We observed that parkin knockdown elevated RTP801 in sympathetic neurons and neuronal PC12 cells, whereas ectopic parkin enhanced RTP801 poly-ubiquitination and proteasomal degradation. In parkin knockout mouse brains and in human fibroblasts from AR-JP patients with parkin mutations, RTP801 levels were elevated. Moreover, in human postmortem PD brains with mutated parkin, nigral neurons were highly positive for RTP801. Further consistent with the idea that RTP801 is a substrate for parkin, the two endogenous proteins interacted in reciprocal co-immunoprecipitates of cell lysates. A potential physiological role for parkin-mediated RTP801 degradation is indicated by observations that parkin protects neuronal cells from death caused by RTP801 overexpression by mediating its degradation, whereas parkin knockdown exacerbates such death. Similarly, parkin knockdown enhanced RTP801 induction in neuronal cells exposed to the Parkinson's disease mimetic 6-hydroxydopamine and increased sensitivity to this toxin. This response to parkin loss of function appeared to be mediated by RTP801 as it was abolished by RTP801 knockdown. Taken together these results indicate that RTP801 is a novel parkin substrate that may contribute to neurodegeneration caused by loss of parkin expression or activity. PMID:25101677

  14. Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease

    PubMed Central

    Canal, Mercè; Martín-Flores, Núria; Pérez-Sisqués, Leticia; Romaní-Aumedes, Joan; Altas, Bekir; Man, Heng-Ye; Kawabe, Hiroshi; Alberch, Jordi; Malagelada, Cristina

    2016-01-01

    Parkinson's disease (PD) is a disorder characterized by the degeneration of certain neuronal populations in the central and peripheral nervous system. One of the hallmarks of the disease is the toxic accumulation of proteins within susceptible neurons due to major impairment in the degradation/clearance protein systems. RTP801 is a pro-apoptotic protein that is sufficient and necessary to induce neuronal death in cellular and animal models of PD. RTP801 is also upregulated in sporadic and parkin mutant PD brains. Here, we report the role of NEDD4, an E3 ligase involved in α-synuclein degradation and PD pathogenesis, in the regulation of RTP801 protein levels and toxicity. NEDD4 polyubiquitinates RTP801 in a cell-free system and in cellular cultures, and they interact physically. NEDD4 conjugates K63-ubiquitin chains to RTP801 and targets it for degradation. NEDD4 regulates RTP801 protein levels in both cultured cells and in the brain tissue. NEDD4 levels are diminished in nigral neurons from human PD brains. Interestingly, neurotoxin 6-OHDA decreases dramatically NEDD4 protein expression but elevates RTP801 protein levels. Moreover, NEDD4 protects neuronal PC12 cells from both 6-OHDA and RTP801-induced toxicity. In primary cortical neurons, NEDD4 knockdown toxicity is mediated by RTP801 since the double knockdown of RTP801 and NEDD4 abrogates the loss of phospho Ser473-Akt and the appearance of caspase-cleaved spectrin fragments. Thus, NEDD4 ligase regulates RTP801 and is sensitive to PD-associated oxidative stress. This suggests that NEDD4 loss of function in PD could contribute importantly into neuronal death by elevating RTP801. PMID:27494837

  15. Concurrent design of an RTP chamber and advanced control system

    SciTech Connect

    Spence, P.; Schaper, C.; Kermani, A.

    1995-12-31

    A concurrent-engineering approach is applied to the development of an axisymmetric rapid-thermal-processing (RTP) reactor and its associated temperature controller. Using a detailed finite-element thermal model as a surrogate for actual hardware, the authors have developed and tested a multi-input multi-output (MIMO) controller. Closed-loop simulations are performed by linking the control algorithm with the finite-element code. Simulations show that good temperature uniformity is maintained on the wafer during both steady and transient conditions. A numerical study shows the effect of ramp rate, feedback gain, sensor placement, and wafer-emissivity patterns on system performance.

  16. 78 FR 24071 - Safety Zone; Pasquotank River; Elizabeth City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Pasquotank River; Elizabeth City, NC AGENCY... on the navigable waters of the Pasquotank River in Elizabeth City, NC in support of the Fireworks... establishing a safety zone on the navigable waters of Pasquotank River in Elizabeth City, NC. The...

  17. 78 FR 72009 - Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Star, NC AGENCY: Federal... at Star, NC, to accommodate a new Area Navigation (RNAV) Global Positioning System (GPS) Standard... Federal Register a notice of proposed rulemaking to establish Class E airspace at Star, NC (78 FR...

  18. Challenges surrounding return-to-play (RTP) for the sports clinician: a case highlighting the need for a thorough three-step RTP model

    PubMed Central

    Menta, Roger; D’Angelo, Kevin

    2016-01-01

    Return-to-play (RTP) is a multifactorial process of retuning an injured athlete back to competition when risk for re-injury is minimized. Traditionally, these decisions are made by medical practitioners based on experience or anecdotal evidence. RTP decisions continue to be a challenging task for the medical practitioner. In the interest of advancing sports medicine for the betterment of athletes, improving the RTP decision-making process with a new paradigm has been suggested.1 It stands to clarify the intricacies used by clinicians when making RTP decisions by providing insight into the multiple factors that must be considered; not only by the athlete and medical practitioner, but all relevant parties (i.e., coaches, trainers, and organizations). This case describes a 19-year-old Ontario Junior Hockey League (OJHL) player who fractured his left clavicle during game play and consequently, suffered a more severe injury to the same clavicle 5½ weeks later by returning to competition against medical advice. This case highlights the potential issues that present when a RTP protocol is poorly executed and addresses the need to adopt a thorough decision-based RTP model proposed by Creighton et al.1 Further, the discussion will draw on current literature and issues surrounding RTP, and the potential legal implications associated with premature return to competition. Given the lack of consensus among sport medicine experts in regards to RTP criteria, the presented model stands to provide a pivotal framework upon which future research can be conducted, while improving the current criteria in place when returning an athlete to competition to aid medical practitioners. PMID:28065992

  19. RTP as an Optional Service: It's Alive, But Is It Well?

    SciTech Connect

    Goldman, Charles; Barbose, Galen; Neenan, Bernie

    2006-03-10

    Economists have advocated for real-time pricing (RTP) of electricity on the basis of the gains in economic efficiency that would result from charging customers the contemporaneous marginal cost of supplying electricity instead of the average cost. In recent years, RTP has also become the subject of interest in a variety of policy contexts, including integrated resource planning initiatives, ongoing efforts to improve efficiency and reliability in competitive electricity markets, and implementation of default service in states with retail choice. Most experience with RTP has been as an optional service, that is, a self-selecting alternative to the standard utility service. By our count, approximately 70 utilities in the U.S. offered an optional RTP program at some point over the past 20 years. However, many programs are now defunct. In 2003, 47 utilities in the U.S. were still offering an optional RTP program, on either a pilot or permanent basis (see Figure 1). In addition, 10 utilities in states with retail choice currently offer RTP as the default service for large customers that are not under contract with a competitive supplier. Another two utilities have received regulatory approval to do so in the next few years. Although the results of a few optional RTP programs have been publicized, the vast majority of programs have operated in relative obscurity. To provide a wider perspective on utility and customer experience with RTP, we surveyed 43 optional RTP programs offered in 2003. We interviewed RTP program managers and other utility staff, and reviewed publicly available sources, including key regulatory documents and program evaluations. Based on this research, we identified trends related to RTP program history and outlook, program design and implementation, customer participation, and participant price response. The results are both surprising and instructive. We conclude that RTP is indeed alive but is not prospering as well it could. Thus, we offer a

  20. 77 FR 35843 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), at Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ...), at Wrightsville Beach, NC; Cape Fear and Northeast Cape Fear River, at Wilmington, NC AGENCY: Coast... Wrightsville Beach, NC; the Cape Fear Memorial Bridge across the Cape Fear River, mile 26.8; and the Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile 1.0; both at Wilmington, NC. The deviation...

  1. Rapid Thermal Processing (RTP) of semiconductors in space

    NASA Technical Reports Server (NTRS)

    Anderson, T. J.; Jones, K. S.

    1993-01-01

    The progress achieved on the project entitled 'Rapid Thermal Processing of Semiconductors in Space' for a 12 month period of activity ending March 31, 1993 is summarized. The activity of this group is being performed under the direct auspices of the ROMPS program. The main objective of this program is to develop and demonstrate the use of advanced robotics in space with rapid thermal process (RTP) of semiconductors providing the test technology. Rapid thermal processing is an ideal processing step for demonstration purposes since it encompasses many of the characteristics of other processes used in solid state device manufacturing. Furthermore, a low thermal budget is becoming more important in existing manufacturing practice, while a low thermal budget is critical to successful processing in space. A secondary objective of this project is to determine the influence of microgravity on the rapid thermal process for a variety of operating modes. In many instances, this involves one or more fluid phases. The advancement of microgravity processing science is an important ancillary objective.

  2. Multichannel interferometer/polarimeter system for the RTP tokamak

    NASA Astrophysics Data System (ADS)

    van Lammeren, A. C. A. P.; Kim, S. K.; Donné, A. J. H.

    1990-10-01

    A nine-channel interferometer/polarimeter system is designed for the RTP tokamak (Rijnhuizen Tokamak Project, a =0.16 m, R =0.72 m, BT =2.5 T, Ip ≤ 200 kA, and plasma pulse duration 200 ms). A CO2-pumped dual-cavity FIR laser system is used to obtain two FIR laser beams of λ =432 μm with a frequency difference of 1 MHz. The FIR beams are expanded by a set of parabolic mirrors. Corner-cube mixers with Schottky diodes are used as detectors. The mixers are mounted on a linear rail system, such that their positions can be easily changed. The interferometer can be operated with a maximum of 19 channels, and will be extended with a polarimeter to measure the poloidal magnetic field distribution. It will be tried to increase the accuracy of the polarimeter by modulating the polarization of the incoming beam. A scheme for polarization modulation which is based on the idea of Dodel and Kunz will be presented in this paper. This scheme has the advantage that only one set of detectors is needed to measure the electron density and current density. The complete system will be presented along with some pilot experiments concerning the polarization modulation.

  3. Rtp801 Suppression of Epithelial mTORC1 Augments Endotoxin-Induced Lung Inflammation

    PubMed Central

    Nadon, Aaron M.; Perez, Mario J.; Hernandez-Saavedra, Daniel; Smith, Lynelle P.; Yang, Yimu; Sanders, Linda A.; Gandjeva, Aneta; Chabon, Jacob; Koyanagi, Daniel E.; Graham, Brian B.; Tuder, Rubin M.; Schmidt, Eric P.

    2015-01-01

    The mechanistic target of rapamycin (mTOR) is a central regulator of cellular responses to environmental stress. mTOR (and its primary complex mTORC1) is, therefore, ideally positioned to regulate lung inflammatory responses to an environmental insult, a function directly relevant to disease states such as the acute respiratory distress syndrome. Our previous work in cigarette smoke–induced emphysema identified a novel protective role of pulmonary mTORC1 signaling. However, studies of the impact of mTORC1 on the development of acute lung injury are conflicting. We hypothesized that Rtp801, an endogenous inhibitor of mTORC1, which is predominantly expressed in alveolar type II epithelial cells, is activated during endotoxin-induced lung injury and functions to suppress anti-inflammatory epithelial mTORC1 responses. We administered intratracheal lipopolysaccharide to wild-type mice and observed a significant increase in lung Rtp801 mRNA. In lipopolysaccharide-treated Rtp801−/− mice, epithelial mTORC1 activation significantly increased and was associated with an attenuation of lung inflammation. We reversed the anti-inflammatory phenotype of Rtp801−/− mice with the mTORC1 inhibitor, rapamycin, reassuring against mTORC1-independent effects of Rtp801. We confirmed the proinflammatory effects of Rtp801 by generating a transgenic Rtp801 overexpressing mouse, which displayed augmented inflammatory responses to intratracheal endotoxin. These data suggest that epithelial mTORC1 activity plays a protective role against lung injury, and its inhibition by Rtp801 exacerbates alveolar injury caused by endotoxin. PMID:25016184

  4. Rtp1p is a karyopherin-like protein required for RNA polymerase II biogenesis.

    PubMed

    Gómez-Navarro, Natalia; Peiró-Chova, Lorena; Rodriguez-Navarro, Susana; Polaina, Julio; Estruch, Francisco

    2013-05-01

    The assembly and nuclear transport of RNA polymerase II (RNA pol II) are processes that require the participation of many auxiliary factors. In a yeast genetic screen, we identified a previously uncharacterized gene, YMR185w (renamed RTP1), which encodes a protein required for the nuclear import of RNA pol II. Using protein affinity purification coupled to mass spectrometry, we identified interactions between Rtp1p and members of the R2TP complex. Rtp1p also interacts, to a different extent, with several RNA pol II subunits. The pattern of interactions is compatible with a role for Rtp1p as an assembly factor that participates in the formation of the Rpb2/Rpb3 subassembly complex and its binding to the Rpb1p-containing subcomplex. Besides, Rtp1p has a molecular architecture characteristic of karyopherins, composed of HEAT repeats, and is able to interact with phenylalanine-glycine-containing nucleoporins. Our results define Rtp1p as a new component of the RNA pol II biogenesis machinery that plays roles in subunit assembly and likely in transport through the nuclear pore complex.

  5. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.

    PubMed

    Cheng, Shu-Yuan; Oh, Seon; Velasco, Marcela; Ta, Christine; Montalvo, Jessica; Calderone, Alyssa

    2014-07-01

    Environmental factors have been implicated in the pathogenesis of neurodegenerative diseases. Maneb (MB) and mancozeb (MZ) have been extensively used as pesticides. Exposure to MB lowers the threshold for dopaminergic damage triggered by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. MB and MZ potentiate 1-methyl-4-phenylpyridium (MPP(+))-induced cytotoxicity in rat pheochromocytoma (PC12) cells partially via nuclear factor kappa B (NF-κB) activation. RTP801 dramatically increased by oxidative stresses and DNA damage is the possible mechanism of neurotoxins-induced cell death in many studies. This study demonstrated that MB and MZ induced DNA damage as seen in comet assay. The expressions of RTP801 protein and mRNA were elevated after MB and MZ exposures. By knocking down RTP801 using shRNA, we demonstrated that NF-κB activation by MB and MZ was regulated by RTP801 and cell death triggered by MB and MZ was associated with RTP801 elevation. This revealed that the toxic mechanisms of dithiocarbamates are via the cross talk between RTP801 and NF-κB.

  6. RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

    PubMed Central

    Canal, Mercè; Romaní-Aumedes, Joan; Martín-Flores, Núria; Pérez-Fernández, Víctor; Malagelada, Cristina

    2014-01-01

    Mechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy. Importantly, mTOR pathway deregulation has been related to many diseases. Indeed, it has become a hallmark in neurodegenerative disorders, since a fine-tuned regulation of mTOR activities is crucial for neuron function and survival. RTP801/REDD1/Dig2 has become one of the most puzzling regulators of mTOR. Although the mechanism is not completely understood, RTP801 inactivates mTOR and Akt via the tuberous sclerosis complex (TSC1/TSC2) in many cellular contexts. Intriguingly, RTP801 protects dividing cells from hypoxia or H2O2-induced apoptosis, while it sensitizes differentiated cells to stress. Based on experimental models of Parkinson’s disease (PD), it has been proposed that at early stages of the disease, stress-induced RTP801 upregulation contributes to mTOR repression, in an attempt to maintain cell function and viability. However, if RTP801 elevation is sustained, it leads to neuron cell death by a sequential inhibition of mTOR and Akt. Here, we will review RTP801 deregulation of mTOR in a context of PD and other neurodegenerative disorders. PMID:25324725

  7. ( RTP, NC ) IMPROVING EMISSION INVENTORIES FOR EFFECTIVE AIR-QUALITY MANAGEMENT ACROSS NORTH AMERICA - A NARSTO ASSESSMENT

    EPA Science Inventory

    The NARSTO Ozone and Particulate Matter Assessments emphasized that emission inventories are critical to the success of air quality management programs and that emissions inventories in Canada, Mexico, and the United States need improvement to meet expectations for quality, timel...

  8. QA Activities on Two Large RARE Projects at the US EPA, RTP, NC ─ from Fish to Humans

    EPA Science Inventory

    Two RARE (Regional Applied Research Effort) projects are being managed by Janet Diliberto, Linda Birnbaum, and Thomas Hughes. Janet is the Project Officer, Linda is the science advisor and Thomas is the QA and Records Manager for these two RARE projects. These are high visibili...

  9. 75 FR 17891 - Amendment of Class D Airspace; Goldsboro, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Goldsboro, NC AGENCY... action proposes to amend the Class D airspace at Seymour Johnson AFB, Goldsboro, NC, to reflect the part... amendment to Title 14, Code of Federal Regulations (14 CFR) part 71 to amend Class D airspace at...

  10. 75 FR 43814 - Amendment of Class D Airspace; Goldsboro, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Goldsboro, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends the Class D... D airspace for Seymour Johnson AFB, Goldsboro, NC (75 FR 17891) Docket No. FAA-2010-0095....

  11. 75 FR 59934 - Amendment to Class E Airspace; Smithfield, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... Federal Aviation Administration 14 CFR Part 71 Amendment to Class E Airspace; Smithfield, NC AGENCY... amends Class E airspace at Johnston County Airport, Smithfield, NC, by correcting an omission of the... amendment of the Class E airspace published in the Federal Register on July 27, 2010 (75 FR 43817)....

  12. 78 FR 44186 - North Carolina Disaster # NC-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster NC-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice... adversely affected by the disaster: Primary Counties: Orange Contiguous Counties: North Carolina:...

  13. RTP1 encodes a novel endoplasmic reticulum (ER)-localized protein in Arabidopsis and negatively regulates resistance against biotrophic pathogens.

    PubMed

    Pan, Qiaona; Cui, Beimi; Deng, Fengyan; Quan, Junli; Loake, Gary J; Shan, Weixing

    2016-03-01

    Oomycete pathogens cause serious damage to a wide spectrum of plants. Although host pathogen recognition via pathogen effectors and cognate plant resistance proteins is well established, the genetic basis of host factors that mediate plant susceptibility to oomycete pathogens is relatively unexplored. Here, we report on RTP1, a nodulin-related MtN21 family gene in Arabidopsis that mediates susceptibility to Phytophthora parasitica. RTP1 was identified by screening a T-DNA insertion mutant population and encoded an endoplasmic reticulum (ER)-localized protein. Overexpression of RTP1 rendered Arabidopsis more susceptible, whereas RNA silencing of RTP1 led to enhanced resistance to P. parasitica. Moreover, an RTP1 mutant, rtp1-1, displayed localized cell death, increased reactive oxygen species (ROS) production and accelerated PR1 expression, compared to the wild-type Col-0, in response to P. parasitica infection. rtp1-1 showed a similar disease response to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) DC3000, including increased disease resistance, cell death and ROS production. Furthermore, rpt1-1 exhibited resistance to the fungal pathogen Golovinomyces cichoracearum, but not to the necrotrophic pathogen Botrytis cinerea. Taken together, these results suggest that RTP1 negatively regulates plant resistance to biotrophic pathogens, possibly by regulating ROS production, cell death progression and PR1 expression.

  14. MASS CONCENTRATION RELATIONSHIPS FROM THE NERL RTP PARTICULATE MATTER PANEL STUDY

    EPA Science Inventory

    The National Exposure Research Laboratory's (NERL) Research Triangle Park (RTP) Particulate Matter (PM) Panel Study has completed a one-year investigation of personal, residential and ambient PM-related mass concentrations in two potentially susceptible subpopulations. PM2.5, P...

  15. 75 FR 13049 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...; Charlotte, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... the Federal Register of March 3, 2010, regarding the modification of Class B airspace, Charlotte,...

  16. 77 FR 64411 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway (AIWW), Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ...), Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of deviation from drawbridge regulation.... 74 Bridge across the Atlantic Intracoastal Waterway, mile 283.1, at Wrightsville Beach, NC. The... Intracoastal Waterway (AIWW) mile 283.1, at Wrightsville Beach, NC has a vertical clearance of 20 feet,...

  17. 78 FR 18848 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ..., Wrightsville Beach, NC and Northeast Cape Fear River, at Wilmington, NC AGENCY: Coast Guard, DHS. ACTION... Beach, NC, and the Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile 1.0, at Wilmington... these sections of the Northeast Cape Fear River and the AIWW. The drawbridges will be able to open...

  18. 75 FR 52461 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ..., Wrightsville Beach, NC and Northeast Cape Fear River, Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice..., mile 283.1, at Wrightsville Beach, NC, and the Isabel S. Holmes Bridge across the Northeast Cape Fear... 283.1, at Wrightsville Beach and the Isabel S. Holmes Bridge across the Northeast Cape Fear...

  19. 77 FR 50376 - Drawbridge Operation Regulation, Atlantic Intracoastal Waterway (AIWW); Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... Waterway (AIWW); Wrightsville Beach, NC; Cape Fear and Northeast Cape Fear River; Wilmington, NC AGENCY... AIWW, mile 283.1 at Wrightsville Beach, NC; the Cape Fear Memorial Bridge across the Cape Fear River, mile 26.8; and the Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile 1.0; both...

  20. 78 FR 54413 - Proposed Establishment of Class E Airspace; Star, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Star, NC AGENCY... action proposes to establish Class E Airspace at Star, NC, to accommodate a new Area Navigation (RNAV... establish Class E airspace at Star, NC, providing the controlled airspace required to support the new...

  1. Fibronectin Binding to the Treponema pallidum Adhesin Protein Fragment rTp0483 on Functionalized Self-Assembled Monolayers

    PubMed Central

    Dickerson, Matthew T.; Abney, Morgan B.; Cameron, Caroline E.; Knecht, Marc; Bachas, Leonidas G.; Anderson, Kimberly W.

    2012-01-01

    Past work has shown that Treponema pallidum, the causative agent of syphilis, binds host fibronectin (FN). FN and other host proteins are believed to bind to rare outer membrane proteins (OMPs) of T. pallidum, and it is postulated that this interaction may facilitate cell attachment and mask antigenic targets on the surface. This research seeks to prepare a surface capable of mimicking the FN binding ability of T. pallidum in order to investigate the impact of FN binding with adsorbed Tp0483 on the host response to the surface. By understanding this interaction it may be possible to develop more effective treatments for infection and possibly mimic the stealth properties of the bacteria. Functionalized self-assembled monolayers (SAMs) on0 gold were used to investigate rTp0483 and FN adsorption. Using a quartz crystal microbalance (QCM) rTp0483 adsorption and subsequent FN adsorption onto rTp0483 was determined to be higher on negatively charged carboxylate-terminated self-assembled monolayers (−COO− SAMs) compared to the other surfaces analyzed. Kinetic analysis of rTp0483 adsorption using surface plasmon resonance (SPR) supported this finding. Kinetic analysis of FN adsorption using SPR revealed a multi-step event, where the concentration of immobilized rTp0483 plays a role in FN binding. An examination of relative QCM dissipation energy compared to the shift in frequency showed a correlation between the physical properties of adsorbed rTp0483 and SAM surface chemistry. In addition, AFM images of rTp0483 on selected SAMs illustrated a preference of rTp0483 to bind as aggregates. Adsorption on −COO− SAMs was more uniform across the surface, which may help further explain why FN bound more strongly. rTp0483 antibody studies suggested the involvement of amino acids 274–289 and 316–333 in binding between rTp0483 to FN, while a peptide blocking study only showed inhibition of binding with amino acids 316–333. Finally, surface adsorbed rTp0483 with FN

  2. Conceptual design of fuel transfer cask for Reactor TRIGA PUSPATI (RTP)

    NASA Astrophysics Data System (ADS)

    Muhamad, Shalina Sheik; Hamzah, Mohd Arif Arif B.

    2014-02-01

    Spent fuel transfer cask is used to transfer a spent fuel from the reactor tank to the spent fuel storage or for spent fuel inspection. Typically, the cask made from steel cylinders that are either welded or bolted closed. The cylinder is enclosed with additional steel, concrete, or other material to provide radiation shielding and containment of the spent fuel. This paper will discuss the Conceptual Design of fuel transfer cask for Reactor TRIGA Puspati (RTP).

  3. RTP801 immunoreactivity in retinal ganglion cells and its down-regulation in cultured cells protect them from light and cobalt chloride.

    PubMed

    del Olmo-Aguado, Susana; Núñez-Álvarez, Claudia; Ji, Dan; Manso, Alberto García; Osborne, Neville N

    2013-09-01

    RTP801, a stress-related protein, is activated by adverse environmental conditions and inhibits the activity of mammalian target of rapamycin (mTOR) in promoting oxidative stress-dependent cell death. RTP801 exists both in the mammalian retina and the lens of the eye. Here, we observed RTP801 immunoreactivity in some retinal ganglion cells. Intravitreal injection of cobalt chloride (CoCl2) to mimick hypoxia influenced retinal GFAP (glial fibrillary acidic protein) and heme oxygenase-1 (HO-1) levels, but did not affect RTP801 immunoreactivity or mRNA content relative to GAPDH. However, RTP801 mRNA was elevated when compared with Brn3a mRNA, suggesting that RTP801 is activated in stressed Brn3a retinal ganglion cells. In cultures of RGC-5 cells, RTP801 immunoreactivity was located in the cytoplasm and partly present in the mitochondria. An insult of blue light or CoCl2 increased RTP801 expression, which was accompanied by cell death. However, in cultures where RTP801 mRNA was down-regulated, the negative influence of blue light and CoCl2 was blunted. Rapamycin nullified the CoCl2-induced up-regulation of RTP801 and attenuated cell death. Moreover, rapamycin was non-toxic to RGC-5 cells, even at a high concentration (10μM). The protective effect of rapamycin on RGC-5 cells caused by the inhibition of RTP801 suggests that rapamycin might attenuate retinal ganglion cell death in situ, as in glaucoma.

  4. 76 FR 23227 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Newport River; Morehead City, NC AGENCY... establishment of a safety zone on the waters of the Newport River under the main span US 70/Morehead City... Fixed bridge crossing Newport River at Morehead City, North Carolina. The contract provides for...

  5. 76 FR 38018 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Newport River; Morehead City, NC AGENCY... on the waters of the Newport River under the main span US 70/Morehead City-Newport River high rise... notice of proposed rulemaking (NPRM) entitled Safety Zone, Newport River; Morehead City, North...

  6. 76 FR 29645 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Newport River; Morehead City, NC AGENCY... on the waters of the Newport River under the main span US 70/Morehead City--Newport River high rise... proposed rulemaking (NPRM) entitled Safety Zone, Newport River; Morehead City, North Carolina in...

  7. 76 FR 18669 - Safety Zone, Newport River; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Newport River; Morehead City, NC AGENCY... establishment a safety zone on the waters of the Newport River under the main span US 70/Morehead City--Newport... Newport River at Morehead City, North Carolina. The contract provides for cleaning, painting, and...

  8. 76 FR 58328 - North Carolina Disaster Number NC-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION North Carolina Disaster Number NC-00036 AGENCY: U.S. Small Business Administration. ACTION... is hereby amended to include the following areas as adversely affected by the disaster:...

  9. 75 FR 4269 - Establishment of Class E Airspace; Hertford, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Hertford, NC AGENCY... September 14, 2009 that establishes Class E Airspace at Harvey Point Defense Testing Activity, Hertford,...

  10. 77 FR 423 - Drawbridge Operation Regulations; Atlantic Intracoastal Waterway (AIWW), Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...), Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations... regulations governing the operation of the S.R. 74 Bridge across the AIWW, mile 283.1, at Wrightsville Beach... structural repair of the bridge. The S.R. 74 Bridge across the AIWW mile 283.1, at Wrightsville Beach, NC...

  11. 75 FR 62320 - Safety Zone; Fireworks for USS GRAVELY Commissioning Ceremony, Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... Fear River, Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a safety zone on the navigable waters of Cape Fear River in Wilmington, NC in... fireworks display on the western shore of the Cape Fear River at Battleship Park. The fireworks...

  12. 78 FR 36664 - Safety Zone; Fifth Coast Guard District Fireworks Display, Currituck Sound; Corolla, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... Display, Currituck Sound; Corolla, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The... adjacent to the Currituck Sound, Corolla, North Carolina. The fireworks display previously originated from... vessel traffic in a portion of the Currituck Sound, Corolla, NC, during the event. DATES: This rule...

  13. 77 FR 31803 - Safety Zone for Fifth Coast Guard District Fireworks Display Currituck Sound; Corolla, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... Display Currituck Sound; Corolla, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking... recurring fireworks event, held adjacent to the Currituck Sound, Corolla, North Carolina. The fireworks... action is intended to restrict vessel traffic in a portion of the Currituck Sound, Corolla, NC,...

  14. A scalable delivery system based on RTP JPEG2000 video stream format

    NASA Astrophysics Data System (ADS)

    Itakura, Eisaburo; Edwards, Eric; Futenma, Satoshi; Tomita, Nobuyoshi; Yamane, Kenji

    2003-11-01

    Demands for scalable delivery systems are increasing for Internet applications. Users want to receive content from a single source regardless of the consumer devices they are using PC, TV, PDA and mobile phone. To realize this type of application, we have developed a scalable delivery system based on a RTP JPEG2000 video stream format that we have proposed to IETF. This system can provide video delivery and Quality of Service from a single layered content for users who require different image quality/resolution/color depending on the device they are using. This system could be a next generation communication platform, allowing us to realize a ubiquitous value network by combining network and codec technologies.

  15. Optical/thermal analysis methodology for a space-qualifiable RTP furnace

    NASA Technical Reports Server (NTRS)

    Bugby, D.; Dardarian, S.; Cole, E.

    1993-01-01

    A methodology to predict the coupled optical/thermal performance of a reflective cavity heating system was developed and a laboratory test to verify the method was carried out. The procedure was utilized to design a rapid thermal processing (RTP) furnace for the Robot-Operated Material Processing in Space (ROMPS) Program which is a planned STS HH-G canister experiment involving robotics and material processing in microgravity. The laboratory test employed a tungsten-halogen reflector/lamp to heat thin, p-type silicon wafers. Measurements instrumentation consisted of 5-mil Pt/Pt-Rh thermocouples and an optical pyrometer. The predicted results, utilizing an optical ray-tracing program and a lumped-capacitance thermal analyzer, showed good agreement with the measured data for temperatures exceeding 1300 C.

  16. 77 FR 3326 - Cancellation of Environmental Impact Statement in Orange County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... Environmental Impact Statement in Orange County, NC AGENCY: Federal Highway Administration (FHWA), North... Elizabeth Brady Road Extension between US 70 Business and US 70 Bypass in Orange County, North Carolina....

  17. 78 FR 14543 - Ward Transformer Superfund Site; Raleigh, Wake County, NC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... AGENCY Ward Transformer Superfund Site; Raleigh, Wake County, NC; Notice of Settlement AGENCY... Agency has entered into a settlement at the Ward Transformer Superfund Site located in Raleigh, Wake... EPA Region 4 contact Ms. Paula V. Painter. Submit your comments by Site name Ward...

  18. AmeriFlux US-NC1 NC_Clearcut

    DOE Data Explorer

    Noormets, Asko [North Carolina State University

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NC1 NC_Clearcut. Site Description - The North Carolina Clearcut site is located in a pine plantation amongst the mixed forests of the North Carolina lower coastal plain. Owned by the Weyerhaeuser Company, the plantation is managed for the purpose of commercial logging. In 2004, 70 ha of 75 year old native hardwoods was harvested. Following the clearcut, the stand was bedded and planted with loblolly pine seedlings. The only significant natural disturbances during the measurement period was a severe drought that lasted from summer of 2007 through 2008. Consequently, the 2007 total amount of precipitation was 486 mm below the 30-year norm.

  19. REAL-TIME PERSONAL NEPHELOMETER AND TIME ACTIVITY DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study was conducted in the Research Triangle Park, NC, area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-populations: a group of African-Americans living in an environm...

  20. PARTICIPANT RECRUITMENT AND RETENTION FOR THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    EPA's National Exposure Research Laboratory (NERL) completed a 12 month Particulate Matter (PM) Panel Study in the Research Triangle Park, NC area in May 2001. A primary goal of the study was to compare PM levels measured at an ambient and residential sites with those from per...

  1. Optimal RTP Based Power Scheduling for Residential Load in Smart Grid

    NASA Astrophysics Data System (ADS)

    Joshi, Hemant I.; Pandya, Vivek J.

    2015-12-01

    To match supply and demand, shifting of load from peak period to off-peak period is one of the effective solutions. Presently flat rate tariff is used in major part of the world. This type of tariff doesn't give incentives to the customers if they use electrical energy during off-peak period. If real time pricing (RTP) tariff is used, consumers can be encouraged to use energy during off-peak period. Due to advancement in information and communication technology, two-way communications is possible between consumers and utility. To implement this technique in smart grid, home energy controller (HEC), smart meters, home area network (HAN) and communication link between consumers and utility are required. HEC interacts automatically by running an algorithm to find optimal energy consumption schedule for each consumer. However, all the consumers are not allowed to shift their load simultaneously during off-peak period to avoid rebound peak condition. Peak to average ratio (PAR) is considered while carrying out minimization problem. Linear programming problem (LPP) method is used for minimization. The simulation results of this work show the effectiveness of the minimization method adopted. The hardware work is in progress and the program based on the method described here will be made to solve real problem.

  2. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis.

    PubMed

    Gupta, Indranil; Ganguly, Souradipta; Rozanas, Christine R; Stuehr, Dennis J; Panda, Koustubh

    2016-07-19

    Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, but also activate Rtp801, a key proinflammatory cellular factor involved in tobacco smoke-induced lung damage. Rtp801 triggers nuclear factor κB and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess superoxide produced during Rtp801 activation, contribute to increased oxido-nitrosative stress and lung protein nitration. However, lung-specific inhibition of iNOS with a iNOS-specific inhibitor, N6-(1-iminoethyl)-L-lysine, dihydrochloride (L-NIL) solely restricts lung protein nitration but fails to prevent or reverse the major tobacco smoke-induced oxidative lung injury. In comparison, the dietary antioxidant, ascorbate or vitamin C, can substantially prevent such damage by inhibiting both tobacco smoke-induced lung protein oxidation as well as activation of pulmonary Rtp801 and consequent iNOS/NO-induced nitration of lung proteins, that otherwise lead to increased proteolysis of such oxidized or nitrated proteins by endogenous lung proteases, resulting in emphysematous lung damage. Vitamin C also restricts the up-regulation of matrix-metalloproteinase-9, the major lung protease involved in the proteolysis of such modified lung proteins during tobacco smoke-induced emphysema. Overall, our findings implicate tobacco-smoke oxidant(s) as the primary etiopathogenic factor behind both the noncellular and cellular damage mechanisms governing emphysematous lung injury and demonstrate the potential of vitamin C to accomplish holistic prevention of such damage.

  3. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis

    PubMed Central

    Gupta, Indranil; Ganguly, Souradipta; Rozanas, Christine R.; Stuehr, Dennis J.

    2016-01-01

    Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, but also activate Rtp801, a key proinflammatory cellular factor involved in tobacco smoke-induced lung damage. Rtp801 triggers nuclear factor κB and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess superoxide produced during Rtp801 activation, contribute to increased oxido-nitrosative stress and lung protein nitration. However, lung-specific inhibition of iNOS with a iNOS-specific inhibitor, N6-(1-iminoethyl)-L-lysine, dihydrochloride (L-NIL) solely restricts lung protein nitration but fails to prevent or reverse the major tobacco smoke-induced oxidative lung injury. In comparison, the dietary antioxidant, ascorbate or vitamin C, can substantially prevent such damage by inhibiting both tobacco smoke-induced lung protein oxidation as well as activation of pulmonary Rtp801 and consequent iNOS/NO-induced nitration of lung proteins, that otherwise lead to increased proteolysis of such oxidized or nitrated proteins by endogenous lung proteases, resulting in emphysematous lung damage. Vitamin C also restricts the up-regulation of matrix-metalloproteinase-9, the major lung protease involved in the proteolysis of such modified lung proteins during tobacco smoke-induced emphysema. Overall, our findings implicate tobacco-smoke oxidant(s) as the primary etiopathogenic factor behind both the noncellular and cellular damage mechanisms governing emphysematous lung injury and demonstrate the potential of vitamin C to accomplish holistic prevention of such damage. PMID:27382160

  4. Customer response to day-ahead wholesale market electricity prices: Case study of RTP program experience in New York

    SciTech Connect

    Goldman, C.; Hopper, N.; Sezgen, O.; Moezzi, M.; Bharvirkar, R.; Neenan, B.; Boisvert, R.; Cappers, P.; Pratt, D.

    2004-07-01

    There is growing interest in policies, programs and tariffs that encourage customer loads to provide demand response (DR) to help discipline wholesale electricity markets. Proposals at the retail level range from eliminating fixed rate tariffs as the default service for some or all customer groups to reinstituting utility-sponsored load management programs with market-based inducements to curtail. Alternative rate designs include time-of-use (TOU), day-ahead real-time pricing (RTP), critical peak pricing, and even pricing usage at real-time market balancing prices. Some Independent System Operators (ISOs) have implemented their own DR programs whereby load curtailment capabilities are treated as a system resource and are paid an equivalent value. The resulting load reductions from these tariffs and programs provide a variety of benefits, including limiting the ability of suppliers to increase spot and long-term market-clearing prices above competitive levels (Neenan et al., 2002; Boren stein, 2002; Ruff, 2002). Unfortunately, there is little information in the public domain to characterize and quantify how customers actually respond to these alternative dynamic pricing schemes. A few empirical studies of large customer RTP response have shown modest results for most customers, with a few very price-responsive customers providing most of the aggregate response (Herriges et al., 1993; Schwarz et al., 2002). However, these studies examined response to voluntary, two-part RTP programs implemented by utilities in states without retail competition.1 Furthermore, the researchers had limited information on customer characteristics so they were unable to identify the drivers to price response. In the absence of a compelling characterization of why customers join RTP programs and how they respond to prices, many initiatives to modernize retail electricity rates seem to be stymied.

  5. 75 FR 81269 - Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... AGENCY Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements AGENCY... Ward Transformer Superfund Site located in Raleigh, Wake County, North Carolina for publication. DATES... your comments, identified by Docket ID No. EPA-RO4- SFUND-2010-1053 or Site name Ward...

  6. 77 FR 4559 - Ecusta Mill Site, Pisgah Forest, Transylvania County, NC; Notice of Amended Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... by Site name Ecusta Mill Superfund Site by one of the following methods: www.epa.gov/region4/waste/sf... AGENCY Ecusta Mill Site, Pisgah Forest, Transylvania County, NC; Notice of Amended Settlement AGENCY... Ecusta Mill Superfund Site located in Pisgah Forest, Transylvania County, North Carolina. DATES:...

  7. 76 FR 14970 - National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... AGENCY National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement AGENCY... National Starch and Chemical Company Site located in Mobile, Mobile County, Alabama for publication. DATES..., identified by Docket ID No. EPA-RO4- SFUND-2011-0278 or Site name National Starch and Chemical...

  8. Status of NC Primer Demonstration & Transition

    DTIC Science & Technology

    2014-11-20

    Primer Demos: Gloss Paint Scheme 4 Demonstration COMPLETE BUNO Induction Date Non- Chrome Primer Date Delivery Date Carrier Deployments...Includes T-6, T-34, T-44, T-45* NC Primer Demos: Gloss Paint Scheme 6 P-3C Demonstration is on-going… • PPG-Deft 02-GN-084 demonstrated over CCC on OML...Only one P-3C demonstrating NC Primer, A/C # 510  Primed Sept. 15, 2011 NC Primer Demos: Gloss Paint Scheme 7 NC Primer Demos: Gloss Paint

  9. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  10. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear...) Except as provided elsewhere in this section from Cape Lookout to Cape Fear, lines drawn parallel...

  11. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear...) Except as provided elsewhere in this section from Cape Lookout to Cape Fear, lines drawn parallel...

  12. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  13. 33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Lookout, NC to Cape Fear, NC... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.525 Cape Lookout, NC to Cape Fear... southeast side of the Inlet. (g) Except as provided elsewhere in this section from Cape Lookout to Cape...

  14. Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid.

    PubMed

    Liu, Li; Yuan, Shifang; Long, Yin; Guo, Zhenjun; Sun, Yang; Li, Yuhua; Niu, Yinbo; Li, Chen; Mei, Qibing

    2009-12-01

    Dexamethasone (DEX) is still the main choice for colitis, although the immunosuppressive side effects are still the troublesome problems to overcome. In our previous study, Rheum tanguticum polysaccharide (RTP), extracted from traditional Chinese medicine rhubarb, targeted mannose receptor, showed immunoregulatory effect on the balance of Th1 and Th2 polarization in colitis rats. For the present study, we hypothesized that RTP could regulate the immunosuppressive effects of DEX. Taking advantage of the colon delivery ability of the polysaccharide, we prepared the double emulsion of RTP microsphere containing DEX to investigate the potential immunoregulatory effects of RTP on DEX immunosuppression in TNBS-induced colitis in rats. As expected, DEX-RTP microsphere showed not only significant immunomodulatory effects, but also strong anti-inflammation. The microsphere balanced enteric bacteria disorder, decreased TLR4 activation and promoted the balance of Th1 and Th2 polarization, inhibited NF-kappaB activity. Especially, DEX-RTP showed significant colon injury reparation. DEX alone exhibited a strong anti-inflammatory effect by suppressing MPO activity, down-regulate NF-kappaB activity and Th1 cytokines production. However, DEX showed severe immunosuppressive effects. It aggravated the intestinal commensal bacteria disorder, induced thymus atrophy and the further imbalance of Th1/Th1 cytokine polarization. RTP showed significant immunoregulatory effects. A significant protection on the intestinal bacterial balance, TLR4 and NF-kappaB activation decreased, and Th1/Th2 cytokine production balance were showed in RTP. In conclusion, DEX-RTP microsphere delivered DEX directly to the colon avoiding the absorption at the upper intestinal tract and showed synergistic effects on colitis both from the strong anti-inflammatory effects of DEX and from the immunoregulation of RTP.

  15. Method Analysis of Microbial-Resistant Gypsum Products

    EPA Science Inventory

    Method Analysis of Microbial-Resistant Gypsum ProductsD.A. Betancourt1, T.R.Dean1, A. Evans2, and G.Byfield2 1. US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory; RTP, NC 277112. RTI International, RTP, NCSeveral...

  16. 75 FR 20859 - Temporary Concession Contract for Blue Ridge Parkway, NC/VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... National Park Service Temporary Concession Contract for Blue Ridge Parkway, NC/VA AGENCY: National Park... Blue Ridge Parkway. SUMMARY: Pursuant to 36 CFR 51.24, public notice is hereby given that the National... services within Blue Ridge Parkway, North Carolina and Virginia for a term not to exceed 3 years....

  17. 77 FR 50444 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast Guard... Carolina Beach, North Carolina. The safety zone is necessary to provide for the safety of mariners on..., mile 295.6, at Carolina Beach, North Carolina. The safety zone will temporarily restrict...

  18. 77 FR 64904 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the waters of the Atlantic Intracoastal Waterway at Carolina Beach..., at Carolina Beach, North Carolina. The safety zone will temporarily restrict vessel movement...

  19. 78 FR 2650 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast... Intracoastal Waterway at Wrightsville Beach, North Carolina. The safety zone is necessary to provide for the... Atlantic Intracoastal Waterway, mile 283.1, at Wrightsville Beach, North Carolina. The safety...

  20. 77 FR 30445 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast... at Wrightsville Beach, North Carolina. The safety zone will temporarily restrict vessel movement..., mile 283.1, at Wrightsville Beach, North Carolina. DATES: Comments and related material must...

  1. 77 FR 35898 - Safety Zone, Atlantic Intracoastal Waterway; North Topsail Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... Topsail Beach, NC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast... at North Topsail Beach, North Carolina. The safety zone will temporarily restrict vessel movement... Topsail Beach, North Carolina. DATES: Comments and related material must be received by the Coast Guard...

  2. 77 FR 41911 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    ...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the waters of the Atlantic Intracoastal Waterway at Wrightsville Beach... Beach, North Carolina. DATES: This rule is effective from September 1, 2012 until May 1, 2013....

  3. 78 FR 34579 - Safety Zone, Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ...; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... Wrightsville Beach, North Carolina. The safety zone is necessary to provide for the safety of mariners on... Waterway, mile 283.1, at Wrightsville Beach, North Carolina. The safety zone extension will...

  4. Regency Centers in Raleigh, NC Awarded 2015 EPA Region 4 Rain Catcher Award

    EPA Pesticide Factsheets

    ATLANTA - The Environmental Protection Agency (EPA) recognized Regency Centers with the regional 2015 EPA Rain Catcher Award in the Commercial Category for the Market at Colonnade project in Raleigh, N.C. The award was given at a ceremony during the

  5. 75 FR 32820 - North Carolina Disaster #NC-00028 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... ADMINISTRATION North Carolina Disaster NC-00028 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration... the Administrator's EIDL declaration, applications for economic injury disaster loans may be filed...

  6. Hickory, N.C., Receives $200,000 EPA Brownfield Grants to Revitalize, Strengthen Local Economy

    EPA Pesticide Factsheets

    ATLANTA - At a press conference in Huntington, W.Va., today, the U.S. Environmental Protection Agency (EPA) announced a $200,000 Brownfields Area-Wide Planning (AWP) grant to the City of Hickory, N.C., for reuse planning that includes residential an

  7. 75 FR 17792 - North Carolina Disaster # NC-00025 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... ADMINISTRATION North Carolina Disaster NC-00025 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration... the Administrator's EIDL declaration, applications for economic injury disaster loans may be filed...

  8. 77 FR 56587 - Safety Zone, Atlantic Intracoastal Waterway; Oak Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Number USCG-2012-0811] RIN 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Oak Island, NC AGENCY... temporary safety zone established on the waters of the Atlantic Intracoastal Waterway at Oak Island, [[Page... 311.8, at Oak Island, North Carolina. The safety zone extension would temporarily restrict...

  9. 78 FR 15797 - Eastern Band of Cherokee Indians Disaster #NC-00049

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Eastern Band of Cherokee Indians Disaster NC-00049 AGENCY: U.S. Small Business Administration... adversely affected by the disaster: Primary Areas: Eastern Band of Cherokee Indians and Associated...

  10. REL3.0 LPLA Monthly NC

    Atmospheric Science Data Center

    2016-10-05

    ... Forcing Surface Skin Temperature Column Precipitable Water Total Cloud Amount Order Data:  Earthdata Search:  ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3.0_lpla_monthly_nc ...

  11. Excited baryons in the 1/Nc expansion

    NASA Astrophysics Data System (ADS)

    Matagne, N.; Stancu, Fl.

    2012-04-01

    We briefly describe the 1/Nc expansion method for studying baryon masses. Two approaches of the large Nc excited baryons have been proposed so far. The first one, based on the Hartree picture, treats the baryon as a ground state core and an excited quark and the second one, suggested recently, considers the baryon globally, without decoupling the system. The masses of excited states of mixed orbital symmetry of nonstrange and strange baryons belonging to the lowest [70, -] multiplet are calculated in the 1/Nc expansion to order 1/Nc with the new method which allows to considerably reduce the number of linearly independent operators entering the mass formula. The status of the resonance Λ(1405) is discussed.

  12. Psychovisual masks and intelligent streaming RTP techniques for the MPEG-4 standard

    NASA Astrophysics Data System (ADS)

    Mecocci, Alessandro; Falconi, Francesco

    2003-06-01

    like: DivX, Xvid, and Cisco"s Mpeg-4IP, have been analyzed but, as for today, they do not support VO). The original code has been deeply modified to integrate the SLIC and to adapt it for real-time streaming. A personal RTP (Real Time Protocol) has been defined and a Client-Server application has been developed. The viewer can decode and demultiplex the stream in real-time, while adapting to the changing modalities adopted by the Server according to the current video content. The proposed codec works as follows: the image background is separated by means of a segmentation module and it is transmitted by means of a wavelet compression scheme similar to that used in the JPEG2000. The VO are coded separately and multiplexed with the background stream. At the receiver the stream is demultiplexed to obtain the background and the VO that are subsequently pasted together. The final quality depends on many factors, in particular: the quantization parameters, the Group Of Video Object (GOV) length, the GOV structure (i.e. the number of I-P-B VOP), the search area for motion compensation. These factors are strongly related to the following measurement parameters (that have been defined during the development): the Objects Apparent Size (OAS) in the scene, the Video Object Incidence factor (VOI), the temporal correlation (measured through the Normalized Mean SAD, NMSAD). The SLIC module analyzes the currently transmitted video and selects the most appropriate settings by choosing from a predefined set of transmission modalities. For example, in the case of a highly temporal correlated sequence, the number of B-VOP is increased to improve the compression ratio. The strategy for the selection of the number of B-VOP turns out to be very different from those reported in the literature for B-frames (adopted for MPEG-1 and MPEG-2), due to the different behaviour of the temporal correlation when limited only to moving objects. The SLIC module also decides how to transmit the background

  13. OXIDATIVE STRESS PARTICIPATES IN PARTICULATE MATTER (PM) INDUCED LUNG INJURY

    EPA Science Inventory

    Oxidative stress participates in particulate matter (PM) induced acute lung injury.
    Elizabeth S. Roberts1, Judy L. Richards2, Kevin L. Dreher2. 1College of Veterinary Medicine, NC State University, Raleigh, NC, 2US Environmental Protection Agency, NHEERL, RTP, NC.
    Epidemiol...

  14. AIR PARTICULATE POLLUTION EXPOSURE INDUCES SYSTEMIC OXIDATIVE STRESS IN HEALTHY MICE

    EPA Science Inventory

    Air particulate pollution exposure induces systemic oxidative stress in healthy mice

    Elizabeth S Roberts1 and Kevin L Dreher2. 1 College or Veterinary Medicine, NC State University, Raleigh, NC , 2US Environmental Protection Agency, NHEERL, RTP, NC

    Epidemiological s...

  15. Asheville, N.C., Among 22 Communities Selected Nationally to Receive EPA Assistance to Advance Sustainability Goals and Foster Economic Development

    EPA Pesticide Factsheets

    ATLANTA - The U.S. Environmental Protection Agency (EPA) today announced that Asheville, N.C., is among 22 communities selected to receive technical assistance to pursue development strategies that support smart growth and sustainability goals and e

  16. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  17. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  18. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N. longitude 78°00.1′ W. across the Cape Fear River Entrance to Oak Island Light....

  19. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N., longitude 78°00.1′ W., across the Cape Fear River Entrance to Oak Island Light....

  20. 33 CFR 80.530 - Cape Fear, NC to Little River Inlet, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Fear, NC to Little River... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.530 Cape Fear, NC to... latitude 33°52.4′ N., longitude 78°00.1′ W., across the Cape Fear River Entrance to Oak Island Light....

  1. GASEOUS CO-POLLUTANTS ASSOCIATED WITH PARTICULATE MATTER-RESULTS FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    The U.S. EPA National Exposure Research Laboratory (NERL) conducted a longitudinal particulate matter (PM) panel study in Research Triangle Park, NC between June 2000 and June 2001. Participants were selected from two potentially susceptible sub-populations: a multi-racial grou...

  2. Use of Trichoderma reesei RT-P1 crude enzyme powder for ethanol fermentation of sweet sorghum fresh stalks.

    PubMed

    Siwarasak, Pongsri; Pajantagate, Pradatrat; Prasertlertrat, Kanoktip

    2012-03-01

    Use of Trichoderma reesei RT-P1 crude enzyme powder and of this powder with 10%v/v Saccharomyces cerevisiae for ethanol fermentation of sweet sorghum fresh stalks were investigated. The optimal conditions were determined by orthogonal experiment method. With T. reesei crude enzyme powder, the optimal condition for the Keller cultivar was at 25 g with 4 g enzyme loading and for the Cowley cultivar at 30 g with 5 g enzyme loading, both with 8 days fermentation at pH 5 and 30°C. At the optimal conditions above, ethanol concentration, productivity and yield of the Cowley cultivar (35.00 g/L, 0.18 g/Lh and 0.38 g ethanol/g substrate, respectively) were higher than those of the Keller cultivar (20.46 g/L, 0.11 g/Lh and 0.28 g ethanol/g substrate). The addition of 10%v/v S. cerevisiae to fermentation at the optimal conditions showed no significant variations in ethanol concentration, productivity and yield for both cultivars.

  3. Strong decays of excited baryons in Large Nc QCD

    SciTech Connect

    Goity, Jose; Scoccola, Norberto

    2007-02-01

    We present the analysis of the strong decays widths of excited baryons in the framework of the 1/Nc expansion of QCD. These studies are performed up to order 1/Nc and include both positive and negative parity excited baryons.

  4. 77 FR 12992 - Amendment of Class E Airspace; Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... amends Class E airspace at Albert J. Ellis Airport, Jacksonville, NC, by updating the geographic... Navigation Services to update the geographic coordinates of Albert J. Ellis Airport, Jacksonville, NC. This... the surface, at Albert J. Ellis Airport, Jacksonville, NC. The geographic coordinates of the...

  5. 76 FR 67056 - Amendment of Class E Airspace; Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    .... This Class E airspace area is effective during the specific days and times established in advance by a Notice to Airmen. The effective days and times will thereafter be continuously published in the Airport... surface of the earth. * * * * * ASO NC E5 Jacksonville, NC Jacksonville, New River MCAS, NC (Lat. 34...

  6. EPA SmartWay Honors Old Dominion Freight Line in Thomasville, N.C., for Superior Supply Chain Efficiency

    EPA Pesticide Factsheets

    ATLANTA - Today, the U.S. Environmental Protection Agency recognized Old Dominion Freight Line, Inc in Thomasville, N.C., with a SmartWay® Excellence Award. Awardees are environmentally responsible carriers that move more goods more miles with lo

  7. City of Durham, N.C. Department of Public Works Awarded 2015 EPA Region 4 Rain Catcher Award

    EPA Pesticide Factsheets

    ATLANTA - The Environmental Protection Agency (EPA) recognized the City of Durham Department of Public Works with the regional 2015 EPA Rain Catcher Award in the Municipal Category for the Rain Catchers project in Durham, N.C. The award was given at

  8. 76 FR 39298 - Drawbridge Operation Regulation; Cape Fear River, and Northeast Cape Fear River, in Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, and Northeast Cape Fear River, in Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from... regulation governing the operation of the Cape Fear River Memorial Bridge across the Cape Fear River, mile...

  9. 75 FR 54770 - Drawbridge Operation Regulations; Cape Fear River and Northeast Cape Fear River, in Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Cape Fear River and Northeast Cape Fear River, in Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from...: The Cape Fear River Memorial Bridge, across Cape Fear River, mile 26.8, and the Isabel S....

  10. 77 FR 37319 - Safety Zone for Fifth Coast Guard District Fireworks Display Pasquotank River; Elizabeth City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone for Fifth Coast Guard District Fireworks Display Pasquotank River; Elizabeth City, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is temporarily changing the enforcement location of a safety zone for...

  11. A Business Case Analysis of the Direct Health Care Provider Program Womack Army Medical Center, Fort Bragg, N.C.

    DTIC Science & Technology

    2001-05-01

    Medical Center, Fort Bragg, N.C. 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Captain Sharon L. Benson 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Commander, Womack Army Medical Center ATTN...MCXC-RES Bldg 4-2817 Reilly Road Fort Bragg, NC 28310 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES

  12. Molecular mechanisms of long ncRNAs in neurological disorders

    PubMed Central

    Vučićević, Dubravka; Schrewe, Heinrich; Ørom, Ulf A.

    2014-01-01

    Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson’s, Alzheimer’s, spinocerebellar ataxia, and Huntington’s diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders. PMID:24624135

  13. Baryons in QCDAS at large Nc: A roundabout approach

    NASA Astrophysics Data System (ADS)

    Cohen, Thomas D.; Shafer, Daniel L.; Lebed, Richard F.

    2010-02-01

    QCDAS, a variant of large Nc QCD in which quarks transform under the color two-index antisymmetric representation, reduces to standard QCD at Nc=3 and provides an alternative to the usual large Nc extrapolation that uses fundamental representation quarks. Previous strong plausibility arguments assert that the QCDAS baryon mass scales as Nc2; however, the complicated combinatoric problem associated with quarks carrying two color indices impeded a complete demonstration. We develop a diagrammatic technique to solve this problem. The key ingredient is the introduction of an effective multigluon vertex: a “traffic circle” or roundabout diagram. We show that arbitrarily complicated diagrams can be reduced to simple ones with the same leading Nc scaling using this device, and that the leading contribution to baryon mass does, in fact, scale as Nc2.

  14. NC10 bacteria in marine oxygen minimum zones.

    PubMed

    Padilla, Cory C; Bristow, Laura A; Sarode, Neha; Garcia-Robledo, Emilio; Gómez Ramírez, Eddy; Benson, Catherine R; Bourbonnais, Annie; Altabet, Mark A; Girguis, Peter R; Thamdrup, Bo; Stewart, Frank J

    2016-08-01

    Bacteria of the NC10 phylum link anaerobic methane oxidation to nitrite denitrification through a unique O2-producing intra-aerobic methanotrophy pathway. A niche for NC10 in the pelagic ocean has not been confirmed. We show that NC10 bacteria are present and transcriptionally active in oceanic oxygen minimum zones (OMZs) off northern Mexico and Costa Rica. NC10 16S rRNA genes were detected at all sites, peaking in abundance in the anoxic zone with elevated nitrite and methane concentrations. Phylogenetic analysis of particulate methane monooxygenase genes further confirmed the presence of NC10. rRNA and mRNA transcripts assignable to NC10 peaked within the OMZ and included genes of the putative nitrite-dependent intra-aerobic pathway, with high representation of transcripts containing the unique motif structure of the nitric oxide (NO) reductase of NC10 bacteria, hypothesized to participate in O2-producing NO dismutation. These findings confirm pelagic OMZs as a niche for NC10, suggesting a role for this group in OMZ nitrogen, methane and oxygen cycling.

  15. 33 CFR 117.822 - Beaufort Channel, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Beaufort Channel, NC. 117.822 Section 117.822 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements North Carolina § 117.822 Beaufort Channel, NC....

  16. 33 CFR 117.822 - Beaufort Channel, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Beaufort Channel, NC. 117.822 Section 117.822 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements North Carolina § 117.822 Beaufort Channel, NC....

  17. ncRNA consensus secondary structure derivation using grammar strings.

    PubMed

    Achawanantakun, Rujira; Sun, Yanni; Takyar, Seyedeh Shohreh

    2011-04-01

    Many noncoding RNAs (ncRNAs) function through both their sequences and secondary structures. Thus, secondary structure derivation is an important issue in today's RNA research. The state-of-the-art structure annotation tools are based on comparative analysis, which derives consensus structure of homologous ncRNAs. Despite promising results from existing ncRNA aligning and consensus structure derivation tools, there is a need for more efficient and accurate ncRNA secondary structure modeling and alignment methods. In this work, we introduce a consensus structure derivation approach based on grammar string, a novel ncRNA secondary structure representation that encodes an ncRNA's sequence and secondary structure in the parameter space of a context-free grammar (CFG) and a full RNA grammar including pseudoknots. Being a string defined on a special alphabet constructed from a grammar, grammar string converts ncRNA alignment into sequence alignment. We derive consensus secondary structures from hundreds of ncRNA families from BraliBase 2.1 and 25 families containing pseudoknots using grammar string alignment. Our experiments have shown that grammar string-based structure derivation competes favorably in consensus structure quality with Murlet and RNASampler. Source code and experimental data are available at http://www.cse.msu.edu/~yannisun/grammar-string.

  18. PM CONCENTRATIONS ASSOCIATED WITH PERSONAL ACTIVITIES BASED ON REAL-TIME PERSONAL NEPHELOMETRY DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study sponsored by EPA's National Exposure Research Laboratory (NERL) was conducted in the Research Triangle Park, NC area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-...

  19. Chiral Lagrangian for baryons in the 1/Nc expansion

    NASA Astrophysics Data System (ADS)

    Jenkins, Elizabeth

    1996-03-01

    A 1/Nc expansion of the chiral Lagrangian for baryons is formulated and used to study the low-energy dynamics of baryons interacting with the pion nonet π, K, η, and η' in a combined expansion in chiral symmetry breaking and 1/Nc. Strong CP violation is included. The chiral Lagrangian correctly implements nonet symmetry and contracted spin-flavor symmetry for baryons in the large Nc limit. The implications of nonet symmetry for low-energy baryon-pion interactions are described in detail. The procedure for calculating nonanalytic pion-loop corrections to baryon amplitudes in the 1/Nc expansion for finite Nc is explained. Flavor-27 baryon mass splittings are calculated at leading order in chiral perturbation theory as an example.

  20. Nucleon-nucleon scattering observables in large- Nc QCD

    NASA Astrophysics Data System (ADS)

    Cohen, Thomas D.; Gelman, Boris A.

    2002-08-01

    Nucleon-nucleon scattering observables are considered in the context of the large Nc limit of QCD for initial states with moderately high momenta ( p∼ Nc). The scattering is studied in the framework of the time-dependent mean-field approximation. We focus on the dependence of those observables on the spin and isospin of the initial state which may be computed using time-dependent mean-field theory. We show that, up to corrections, all such observables must be invariant under simultaneous spin and isospin flips (i.e., rotations through π/2 in both spin and isospin) acting on either particle. All observables of this class obtained from spin unpolarized measurements must be isospin independent up to 1/ Nc corrections. Moreover, it can be shown that the leading correction is of relative order 1/ Nc2 rather than 1/ Nc.

  1. FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models.

    PubMed

    Bao, X-Q; Kong, X-C; Qian, C; Zhang, D

    2012-01-27

    The pathogenesis of Parkinson's disease is characterized by progressive degeneration of dopaminergic neurons in substantia nigra (SNpc). FLZ, a novel synthetic squamosamide derivative from a Chinese herb, has been shown to have neuroprotective effects in experimental Parkinson's disease (PD) models. However, it is still unclear whether FLZ protects against PD through regulating the function of dopaminergic system. In this study, we carried out a set of in vitro and in vivo experiments to address these questions. Oral administration of FLZ significantly improved motor dysfunction of mice challenged by MPTP. The beneficial effects of FLZ on motor behavior attributed to the elevation of dopamine level in striatum, tyrosine hydroxylase (TH)-positive cells, and TH activity in the middle brain of mouse. Mechanism study showed that treatment of FLZ increased the phosphorylation of activating protein kinase B (Akt) and mammalian target of rapamycin (mTOR). Using LY294002 to block phosphoinositide 3-kinases (PI3K)/Akt signaling pathway prevented the phosphorylation of mTOR and attenuated the neuroprotection of FLZ in MN9D cells challenged by MPP(+). In addition, FLZ reduced the expression of RTP801, an important protein in PD, in mice and cells intoxicated by MPTP/MPP(+). Taken together, these results revealed a novel role that FLZ elevated TH expression and activity in dopaminergic neuron through activation of Akt/mTOR survival pathway and inhibition of RTP801 in MPTP/MPP(+)-induced PD models. The data also provided evidence that FLZ had potent neuroprotecive effects and might become a new promising anti-PD drug.

  2. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-5301; R-5302A, B, and C; and R-5313A, B, C and D...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Areas R-5301; R-5302A, B, and C; and R-5313A, B, C and D; NC AGENCY: Federal Aviation Administration... agency for restricted areas R-5301 Albemarle Sound, NC; R-5302A, B and C, Harvey Point, NC; and R-5313A... areas R-5301; R-5302A, B and C; and R-5313A, B, C and D, in North Carolina by removing the words...

  3. 75 FR 38127 - Sherrill Furniture, Hickory White Furniture Division Hickory, NC; Including Workers of Hickory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... Employment and Training Administration Sherrill Furniture, Hickory White Furniture Division Hickory, NC; Including Workers of Hickory White Upholstery High Point, NC in Support of Sherrill Furniture Hickory White Furniture Division Hickory, NC; Amended Certification Regarding Eligibility To Apply for Worker...

  4. 78 FR 45188 - Agency Information Collection Activities; Proposed Collection; Comment Request; 8-Hour Ozone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ..., mechanical or other technological collection techniques or other forms of information technology, e.g., by... Protection Agency, T.W. Alexander Drive, Research Triangle Park, NC 27711; telephone number: (919)...

  5. Micro-focused Small Angle Neutron Scattering and Imaging for Science and Engineering Using RTP--A Preliminary Study

    SciTech Connect

    Mohamed, Abdul Aziz; Al Rashid Megat Ahmad, Megat Harun; Md Idris, Faridah; Azman, Azraf; Jamro, Rafhayudi; Ibrahim, Mohd Rizal Mamat; Rahman, Anwar Abdul

    2010-01-05

    Malaysian Nuclear Agency's (Nuclear Malaysia) Small Angle Neutron Scattering (SANS) facility--(MYSANS)--is utilizing low flux of thermal neutron at the agency's 1 MW TRIGA reactor. As the design nature of the 8 m SANS facility can allow object resolution in the range between 5 and 80 nm to be obtained. It can be used to study alloys, ceramics and polymers in certain area of problems that relate to samples containing strong scatterers or contrast. The current SANS system at Malaysian Nuclear Agency is only capable to measure Q in limited range with a PSD (128x128) fixed at 4 m from the sample. The existing reactor hall that incorporate this MYSANS facility has a layout that prohibits the rebuilding of MYSANS therefore the position between the wavelength selector (HOPG) and sample and the PSD cannot be increased for wider Q range. The flux of the neutron at current sample holder is very low which around 10{sup 3} n/cm{sup 2}/sec. Thus it is important to rebuild the MYSANS to maximize the utilization of neutron. Over the years, the facility has undergone maintenance and some changes have been made. Modification on secondary shutter and control has been carried out to improve the safety level of the instrument. A compact micro-focus SANS method can suit this objective together with an improve cryostat system. This paper will explain some design concept and approaches in achieving higher flux and the modification needs to establish the micro-focused SANS.

  6. AmeriFlux US-NC2 NC_Loblolly Plantation

    SciTech Connect

    Noormets, Asko

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NC2 NC_Loblolly Plantation. Site Description - The North Carolina Loblolly Pine site is located in a pine plantation amongst the mixed forests of the North Carolina lower coastal plain. During the late 19th and early 20th centuries the region was logged extensively. After a series of clearcuts, the land was transformed for agricultural practices. In 1967 and 1969, 4000 ha was sold to the Weyerhauser company for agriculture, preservation, and commercial logging of loblolly pines in a series of plantations. The fifth rotation stand surrounding the tower was established in 1992. The only significant natural disturbances during the measurement period was a severe drought that spanned the entire duration of the 2007 growing season. Consequently, the 2007 total amount of precipitation was 486 mm below the 30-year norm. In the same year, the plantation was thinned and fertilized. The stand was thinned in Oct 2009. The eastern half of the site was fertilized in January 2011, and the entire site was fertilized in October 2012.

  7. EPA to Hold a Public Meeting About Proposed Plan to Clean Up Soil Contamination at Benfield Industries, Inc. Superfund Site in Waynesville, N.C.

    EPA Pesticide Factsheets

    ATLANTA - On Tuesday, Jan. 13, the U.S. Environmental Protection Agency (EPA) will hold a public meeting about plans to clean up residual soil contamination at the Benfield Industries, Inc. Superfund Site in Waynesville, N.C. The meeting will be hel

  8. REL3.0 SW MONTHLY UTC NC

    Atmospheric Science Data Center

    2016-10-05

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3_sw_monthly_nc ...

  9. REL3.0 SW 3HRLY NC

    Atmospheric Science Data Center

    2016-10-05

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3.0_sw_3hrly_nc ...

  10. REL3.0 SW MONTHLY LOCAL NC

    Atmospheric Science Data Center

    2016-10-05

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3_sw_monthly_nc ...

  11. REL3.0 SW Daily UTC NC

    Atmospheric Science Data Center

    2016-10-05

    ... Active Radiation Flux Cloud Fraction Cosine Solar Zenith Angle From Satellite Cosine Solar Zenith Angle From Astronomy ... ISCCP Data Table SSE Renewable Energy Readme Files:  Readme_3.0_sw_daily_nc ...

  12. RadNet Air Data From Greensboro, NC

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Greensboro, NC from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  13. 76 FR 49664 - Drawbridge Operation Regulation; Beaufort Channel, Beaufort, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... Triathlon''. This deviation allows the bridge to remain in the closed position during the race to ensure the..., at Beaufort, NC. The bike route of the ``Neuse Riverkeeper Foundation Sprint Triathlon'' crosses...

  14. Large Nc from Seiberg-Witten curve and localization

    NASA Astrophysics Data System (ADS)

    Russo, Jorge G.

    2015-09-01

    When N = 2 gauge theories are compactified on S4, the large Nc limit then selects a unique vacuum of the theory determined by saddle-point equations, which remains determined even in the flat-theory limit. We show that exactly the same equations can be reproduced purely from Seiberg-Witten theory, describing a vacuum where magnetically charged particles become massless, and corresponding to a specific degenerating limit of the Seiberg-Witten spectral curve where 2Nc - 2 branch points join pairwise giving aDn = 0, n = 1 , … ,Nc - 1. We consider the specific case of N = 2 SU (Nc) SQCD coupled with 2Nf massive fundamental flavors. We show that the theory exhibits a quantum phase transition where the critical point describes a particular Argyres-Douglas point of the Riemann surface.

  15. INGEN: A COBRA-NC input generator user's manual

    SciTech Connect

    Wheeler, C.L.; Dodge, R.E.

    1986-12-01

    The INGEN (INput GENerator) computer program has been developed as a preprocessor to simplify input generation for the COBRA-NC computer program. INGEN uses several empirical correlations and geometric assumptions to simplify the data input requirements for the COBRA-NC computer code. The simplified input scheme is obtained at the expense of much flexibility provided by COBRA-NC. For more complex problems requiring additional flexibility however, INGEN may be used to provide a skeletal input file to which the more detailed input may be added. This report describes the input requirements for INGEN and describes the algorithms and correlations used to generate the COBRA-NC input. 9 refs., 3 figs., 6 tabs.

  16. RadNet Air Data From Charlotte, NC

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Charlotte, NC from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  17. RadNet Air Data From Raleigh, NC

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Raleigh, NC from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  18. RadNet Air Data From Wilmington, NC

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Wilmington, NC from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  19. precision deburring using NC and robot equipment. Final report

    SciTech Connect

    Gillespie, L.K.

    1980-05-01

    Deburring precision miniature components is often time consuming and inconsistent. Although robots are available for deburring parts, they are not precise enough for precision miniature parts. Numerical control (NC) machining can provide edge break consistencies to meet requirements such as 76.2-..mu..m maximum edge break (chamfer). Although NC machining has a number of technical limitations which prohibits its use on many geometries, it can be an effective approach to features that are particularly difficult to deburr.

  20. Geologic and hydrologic data collected at test holes NC-6 and NC-11, Hatillo and Isabela, northwestern Puerto Rico

    USGS Publications Warehouse

    Rodríguez-Martínez, Jesús; Hartley, John L.

    1994-01-01

    Test holes NC-6 and NC-11 were drilled in the municipalities of Hatillo and Isabela, respectively, as part of a study of the aquifers in the Northern Coastal Province of Puerto Rico. Test holes NC-6 and NC-11 were drilled to depths of 2,574 and 2,120 feet below land surface, respectively. Geologic and hydrologic data collected during drilling included continuous core, water-quality samples, water-level measurements, and estimates of aquifer yields from the water-bearing zones. Test hole NC-6 penetrated five formations ranging in age from late Oligocene to early Pliocene: the Lares Limestone, the Cibao Formation, the Los Puertos Formation, the Aymamon Limestone, and the Quebradillas Limestone. This test hole also penetrated a water-table aquifer and six artesian aquifer. Test hole NC-11 penetrated four formations ranging in age from late 01igocene to middle Miocene: the San Sebastian Formation, the Cibao Formation, the Los Puertos, and the Aymamon Limestone. A water-table aquifer and four artesian aquifers were penetrated by this well.

  1. PERSONAL PARTICULATE MATTER EXPOSURE MONITORING: IDENTIFYING IMPORTANT SOURCES, ACTIVITIES, AND LOCATIONS BASED ON DATA FROM THE NERL RTP PM PANEL STUDY

    EPA Science Inventory

    A longitudinal particulate matter (PM) exposure study was conducted in the Research Triangle Park, NC area between June 2000 and June 2001. Participants were selected from two groups of potentially susceptible sub-populations: a group of African-Americans living in an environme...

  2. Genomewide comparison and novel ncRNAs of Aquificales

    PubMed Central

    2014-01-01

    Background The Aquificales are a diverse group of thermophilic bacteria that thrive in terrestrial and marine hydrothermal environments. They can be divided into the families Aquificaceae, Desulfurobacteriaceae and Hydrogenothermaceae. Although eleven fully sequenced and assembled genomes are available, only little is known about this taxonomic order in terms of RNA metabolism. Results In this work, we compare the available genomes, extend their protein annotation, identify regulatory sequences, annotate non-coding RNAs (ncRNAs) of known function, predict novel ncRNA candidates, show idiosyncrasies of the genetic decoding machinery, present two different types of transfer-messenger RNAs and variations of the CRISPR systems. Furthermore, we performed a phylogenetic analysis of the Aquificales based on entire genome sequences, and extended this by a classification among all bacteria using 16S rRNA sequences and a set of orthologous proteins. Combining several in silico features (e.g. conserved and stable secondary structures, GC-content, comparison based on multiple genome alignments) with an in vivo dRNA-seq transcriptome analysis of Aquifex aeolicus, we predict roughly 100 novel ncRNA candidates in this bacterium. Conclusions We have here re-analyzed the Aquificales, a group of bacteria thriving in extreme environments, sharing the feature of a small, compact genome with a reduced number of protein and ncRNA genes. We present several classical ncRNAs and riboswitch candidates. By combining in silico analysis with dRNA-seq data of A. aeolicus we predict nearly 100 novel ncRNA candidates. PMID:24965762

  3. NC10 Bacteria in a Marine Oxygen Minimum Zone

    NASA Astrophysics Data System (ADS)

    Padilla, C. C.; Bristow, L. A.; Benson, C. R.; Sarode, N. D.; Girguis, P. R.; Glass, J. B.; DiChristina, T. J.; Thamdrup, B.; Stewart, F. J.

    2014-12-01

    Marine oxygen minimum zones (OMZs) are key regions of nitrogen cycling and nitrogen loss as N2. The potential for methane cycling to influence OMZ nitrogen budgets remains largely unknown. The anaerobic oxidation of methane (AOM) coupled to nitrite or nitrate reduction has been shown to be a potential source of methane consumption, N loss, and oxygen production in freshwater sediments, but has not been described for marine pelagic environments. Nitrite-dependent AOM is performed by bacteria of the candidate division NC10 through an intra-aerobic pathway involving the dismutation of nitric oxide to O2 and N2. We explored the potential that NC10-like bacteria are present and active in the anoxic, nitrite-rich OMZ of the Eastern Tropical North Pacific. Community transcriptome sequencing confirmed the expression of genes with top matches to the NC10 bacterium 'Candidatus Methylomirabilis oxyfera.' NC10-like transcripts increased in relative abundance with depth into the anoxic OMZ core and included genes of aerobic methanotrophy and denitrification, as well as high numbers of transcripts matching norZ nitric oxide reductase, hypothesized to play a role in the O2-yielding dismutation reaction. Phylogenetic analysis of OMZ particulate methane monooxygenase (pmoA) and 16S rRNA gene sequences recovered by PCR revealed multiple clades of NC10 phylotypes in the OMZ. Preliminary data from OMZ enrichments revealed methane-dependent nitrite consumption, but further characterization is required to identify the pathways and organisms mediating this process. These findings expand the known environmental range of NC10 and suggest the possibility of previously uncharacterized linkages between OMZ nitrogen and methane cycles.

  4. Negative Parity Baryon Decays in the 1/Nc Expansion

    SciTech Connect

    Chandana Jayalath, Jose L. Goity, Norberto N. Scoccola

    2010-08-01

    The $1/N_c$ expansion of QCD provides a useful framework for phenomenological studies of both ground state and excited baryons. Here, we focus on its application to the excited baryon strong decays via emission of single pseudoscalar meson. The S- and D-wave decay amplitudes of the negative parity baryons in the $[70,1^-]$ of $SU(6)$ are analyzed to subleading order in $1/N_c$ and to first order in SU(3) symmetry breaking. In particular, the SU(3) symmetry breaking is studied in detail through SU(3) breaking decay operators and state mixing.

  5. Eikonal gluon bremsstrahlung at finite Nc beyond two loops

    NASA Astrophysics Data System (ADS)

    Delenda, Yazid; Khelifa-Kerfa, Kamel

    2016-03-01

    We present a general formalism for computing the matrix-element squared for the emission of soft energy-ordered gluons beyond two loops in QCD perturbation theory at finite Nc. Our formalism is valid in the eikonal approximation. A Mathematica program has been developed for the automated calculation of all real/virtual eikonal squared amplitudes needed at a given loop order. For the purpose of illustration, we show the explicit forms of the eikonal squared amplitudes up to the fifth-loop order. In the large-Nc limit, our results coincide with those previously reported in literature.

  6. Government Agencies

    DTIC Science & Technology

    1988-05-01

    manufacturers. The Navy has a major in- house design capability for ships; the government does not possess such a capability for aircraft or other weapon systems...the Coast Guard, government agencies acquire a wide variety of ships, ranging from sophisticated submarines and nuclear aircraft carriers to much...the initial phase a review was made of written material relating to government procedures in U.S. Government agencies for acquiring vessels, aircraft

  7. Can the nucleon axial charge be O(Nc0)?

    NASA Astrophysics Data System (ADS)

    Kojo, Toru

    2013-02-01

    The nucleon self-energy and its relation to the nucleon axial charge gA are discussed at large Nc. The energy is compared for the hedgehog, conventional, and recently proposed dichotomous nucleon wavefunctions which give different values for gA. We consider their energies at both perturbative and non-perturbative levels. In perturbative estimates, we take into account the pion exchanges among quarks up to the third orders of axial charge vertices, including the many-body forces such as the Wess-Zumino terms. It turns out that the perturbative pion exchanges among valence quarks give the same leading Nc contributions for three wavefunctions, while their mass differences are O(ΛQCD). The signs of splittings flip for different orders of the axial charge vertices, so it is hard to conclude which one is the most energetically favored. For non-perturbative estimates involving the modification of quark bases, we use the chiral quark soliton model as an illustration. With the hedgehog quark wavefunctions with gA of O(Nc), we investigate whether solutions with coherent pions are energetically favored. Again it is hard to give decisive conclusions, but it is possible that adding the confining effects disfavors the solution with the coherent pions, making a pion cloud around a nucleon quantum rather than coherent. The nuclear matter at large Nc is also discussed in light of the value of gA.

  8. 75 FR 20320 - Amendment of Class E Airspace; Smithfield, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... needed for the Standard Instrument Approach Procedures (SIAPs) developed for Johnston County Airport... Smithfield, NC to provide controlled airspace required to support the SIAPs for Johnston County Airport. The... within the scope of that authority as it would amend Class E airspace at Johnston County...

  9. 76 FR 55554 - Amendment of Class E Airspace; Rutherfordton, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... airspace at Rutherfordton, NC. The Rutherford Non-Directional Beacon (NDB) has been decommissioned and new Standard Instrument Approach Procedures have been developed for Rutherford County-Marchman Field. This... standard instrument approach procedures developed at Rutherford County-Marchman Field, Rutherfordton,...

  10. Weak meson decays and the 1/Nc expansion

    NASA Astrophysics Data System (ADS)

    Tadić, Dubravko; Trampetić, Josip

    1982-07-01

    In the QCD corrected weak hamiltonian, the leading terms in the large-Nc limit give a reasonable description of D--> Kπ decays and good values of K --> ππ decay amplitudes. Alexander von Humboldt Fellow of Max-Planck Institut für Physik und Astrophysik, Munich, Fed. Rep. Germany.

  11. Total nucleon-nucleon cross sections in large Nc QCD

    NASA Astrophysics Data System (ADS)

    Cohen, Thomas D.; Gelman, Boris A.

    2012-02-01

    We use contracted spin-flavor symmetry which emerges in the large Nc limit of QCD to obtain relations between proton-proton and proton-neutron total cross sections for both polarized and unpolarized scattering. The formalism used is valid in the semiclassical regime in which the relative momentum of the incident nucleons is much larger than the inverse size of the nucleon, provided that certain technical assumptions are met. The relations should be phenomenologically useful provided that Nc=3 is sufficiently large so that the large Nc results have at least semiquantitative predictive power. The relations are model independent in the sense that they depend on properties of large Nc QCD only and not on any particular model-dependent details of the nucleon-nucleon interaction. We compare these model-independent results to the experimental data. We find the relation for spin-unpolarized scattering works well empirically. For the case of polarized scattering, the data are consistent with the relations, but the cross sections are too small to make sharp predictions.

  12. Baryon Regge Trajectories and the 1/Nc Expansion

    SciTech Connect

    Goity, Jose; Matagne, Nicolas

    2008-12-01

    Baryon Regge trajectories are discussed in the light of the 1/Nc expansion. The approximate dynamical symmetry SU(6)x O(3) is used to identify the spin-flavor singlet component of baryon masses. By fitting to the known baryon spectrum, this component is shown to produce distinct Regge trajectories for SU(6) 56- and 70-plets which are remarkably linear.

  13. 77 FR 23597 - Revocation of Class E Airspace; Southport, NC, and Establishment of Class E Airspace; Oak Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., NC, as new Standard Instrument Approach Procedures have been developed at Cape Fear Regional Jetport... change to Cape Fear Regional Jetport/Howie Franklin Field and updates the geographic coordinates of the... extending upward from 700 feet above the surface at Cape Fear Regional Jetport/Howie Franklin Field,...

  14. Mechanism of Nucleic Acid Chaperone Function of Retroviral Nuceleocapsid (NC) Proteins

    NASA Astrophysics Data System (ADS)

    Rouzina, Ioulia; Vo, My-Nuong; Stewart, Kristen; Musier-Forsyth, Karin; Cruceanu, Margareta; Williams, Mark

    2006-03-01

    Recent studies have highlighted two main activities of HIV-1 NC protein contributing to its function as a universal nucleic acid chaperone. Firstly, it is the ability of NC to weakly destabilize all nucleic acid,(NA), secondary structures, thus resolving the kinetic traps for NA refolding, while leaving the annealed state stable. Secondly, it is the ability of NC to aggregate NA, facilitating the nucleation step of bi-molecular annealing by increasing the local NA concentration. In this work we use single molecule DNA stretching and gel-based annealing assays to characterize these two chaperone activities of NC by using various HIV-1 NC mutants and several other retroviral NC proteins. Our results suggest that two NC functions are associated with its zinc fingers and cationic residues, respectively. NC proteins from other retroviruses have similar activities, although expressed to a different degree. Thus, NA aggregating ability improves, and NA duplex destabilizing activity decreases in the sequence: MLV NC, HIV NC, RSV NC. In contrast, HTLV NC protein works very differently from other NC proteins, and similarly to typical single stranded NA binding proteins. These features of retroviral NCs co-evolved with the structure of their genomes.

  15. Decays of excited baryons in the large Nc expansion of QCD

    SciTech Connect

    Jose Goity; Norberto Scoccola

    2006-05-06

    We present the analysis of the decay widths of excited baryons in the framework of the 1/Nc expansion of QCD. These studies are performed up to order 1/Nc and include both positive and negative parity excited baryons.

  16. 76 FR 54794 - Klaussner Furniture Industries, Inc., Plant #3, Asheboro, NC; Klaussner Furniture Industries, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... Employment and Training Administration Klaussner Furniture Industries, Inc., Plant 3, Asheboro, NC; Klaussner Furniture Industries, Inc., Plant 33, Asheboro, NC; Klaussner Corporate Services, Inc., Also Known as Klaussner of Iowa, a Division of Klaussner Furniture Industries, Inc., Milford, IA; Amended...

  17. INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV)-INDUCED INFLAMMATION BY 3-NITROTYROSINE IN HUMAN BRONCHIAL EPITHELIAL CELLS

    EPA Science Inventory

    Inhibition of Respiratory Syncytial Virus (RSV)-Induced Inflammation by 3-Nitrotyrosine in Human Bronchial Epithelial Cells. J. M. Soukup, MPH 1, ZW. Li, MD 2 and YC. T. Huang, MD 1. 1 NHEERL, US Environmental Protection Agency, RTP, NC and 2 CEMALB, University of North Carolina,...

  18. ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATE

    EPA Science Inventory

    ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATE

    Cynthia Wolf1,2 , Joe Ostby1, Jonathan Furr 1, Gerald A. LeBlanc2, and L. Earl Gray, Jr.1
    1 US Environmental Protection Agency, NHEERL, RTD, RTP, NC 27711, 2 Departmen...

  19. THE EFFECT OF SUBMAXIMAL INHALATION ON MEASURES DERIVED FROM FORCED EXPIRATORY SPIROMETRY

    EPA Science Inventory

    THE EFFECT OF SUBMAXIMAL INHALATION ON MEASURES DERIVED FROM FORCED EXPIRATORY SPIROMETRY. William F. McDonnell Human Studies Division, NHEERL, U.S. Environmental Protection Agency, RTP, NC 27711.
    Short-term exposure to ozone results in a neurally-mediated decrease in the ab...

  20. RNA PROFILES IN RAT AND MOUSE EPIDIDYMAL SPERMATOZOA

    EPA Science Inventory

    RNA PROFILES IN RAT AND MOUSE EPIDIDYMAL SPERMATOZOA
    Kary E. Thompson1, Hongzu Ren1, Judith E. Schmid1 and David J. Dix1
    1Reproductive Toxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, RTP, NC.

    Mature spermatozoa are transcriptionally inactive...

  1. Error bounded conic spline approximation for NC code

    NASA Astrophysics Data System (ADS)

    Shen, Liyong

    2012-01-01

    Curve fitting is an important preliminary work for data compression and path interpolator in numerical control (NC). The paper gives a simple conic spline approximation algorithm for G01 code. The algorithm is mainly formed by three steps: divide the G01 code to subsets by discrete curvature detection, find the polygon line segment approximation for each subset within a given error and finally, fit each polygon line segment approximation with a conic Bezier spline. Naturally, B-spline curve can be obtained by proper knots selection. The algorithm is designed straightforward and efficient without solving any global equation system or optimal problem. It is complete with the selection of curve's weight. To design the curve more suitable for NC, we present an interval for the weight selection and the error is then computed.

  2. Error bounded conic spline approximation for NC code

    NASA Astrophysics Data System (ADS)

    Shen, Liyong

    2011-12-01

    Curve fitting is an important preliminary work for data compression and path interpolator in numerical control (NC). The paper gives a simple conic spline approximation algorithm for G01 code. The algorithm is mainly formed by three steps: divide the G01 code to subsets by discrete curvature detection, find the polygon line segment approximation for each subset within a given error and finally, fit each polygon line segment approximation with a conic Bezier spline. Naturally, B-spline curve can be obtained by proper knots selection. The algorithm is designed straightforward and efficient without solving any global equation system or optimal problem. It is complete with the selection of curve's weight. To design the curve more suitable for NC, we present an interval for the weight selection and the error is then computed.

  3. 77 FR 25652 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), at Wrightsville Beach, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... Waterway (AIWW), at Wrightsville Beach, NC; Cape Fear and Northeast Cape Fear River, at Wilmington, NC...) bridges: The S.R. 74 Bridge, across the AIWW, mile 283.1 at Wrightsville Beach, NC; the Cape Fear Memorial Bridge across the Cape Fear River, mile 26.8; and the Isabel S. Holmes Bridge across the Northeast...

  4. Prevalence and Dynamics of Antibodies against NcSAG1 and NcGRA7 Antigens of Neospora caninum in Cattle during the Gestation Period

    PubMed Central

    TAKASHIMA, Yasuhiro; TAKASU, Masaki; YANAGIMOTO, Isao; HATTORI, Naoki; BATANOVA, Tatiana; NISHIKAWA, Yoshifumi; KITOH, Katsuya

    2013-01-01

    ABSTRACT Bovine abortion caused by the Apicomplexan parasite Neospora caninum is a major economic problem in the livestock industry worldwide. Our study measured the prevalence and temporal changes in levels of antibodies specific for two N. caninum derived antigens, NcSAG1 and NcGRA7, to determine an appropriate strategy for serodiagnosis. Using an enzyme-linked immunosorbent assay (ELISA), blood samples showed that 71 cows out of 129 were positive for anti-NcSAG1 antibodies and that only nine cows were positive for anti-NcGRA7 antibodies. By longitudinal sampling, it was revealed that positive and negative antibody conversion occurred frequently for anti-NcGRA7, but that anti-NcSAG1 antibodies persisted for a long-term. These results indicate the usefulness of measuring anti-NcSAG1 antibody levels for the detection of chronically infected cows. Twelve cows showed positive seroconversion during pregnancy, nine of which showed seropositivity for anti-NcGRA7 antibody at the sixth and/or seventh month of pregnancy; serum samples were not obtained from the remaining three cows during this period. Therefore, the optimal time for detection of anti-NcGRA7 antibodies appears to be between the fifth and eighth month of pregnancy. PMID:23782543

  5. 75 FR 62182 - Notice of Final Federal Agency Actions on Proposed Highway in North Carolina

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... agency actions subject to 23 U.S.C. 139 (I)(1). A claim seeking judicial review of the Federal agency... by the FHWA and other Federal agencies that are final within the meaning of 23 U.S.C. 139 (I)(1). The actions relate to a proposed highway project, NC 24 Improvements, from 2.8 miles east of I-95 to I-40...

  6. Research on NC motion controller based on SOPC technology

    NASA Astrophysics Data System (ADS)

    Jiang, Tingbiao; Meng, Biao

    2006-11-01

    With the rapid development of the digitization and informationization, the application of numerical control technology in the manufacturing industry becomes more and more important. However, the conventional numerical control system usually has some shortcomings such as the poor in system openness, character of real-time, cutability and reconfiguration. In order to solve these problems, this paper investigates the development prospect and advantage of the application in numerical control area with system-on-a-Programmable-Chip (SOPC) technology, and puts forward to a research program approach to the NC controller based on SOPC technology. Utilizing the characteristic of SOPC technology, we integrate high density logic device FPGA, memory SRAM, and embedded processor ARM into a single programmable logic device. We also combine the 32-bit RISC processor with high computing capability of the complicated algorithm with the FPGA device with strong motivable reconfiguration logic control ability. With these steps, we can greatly resolve the defect described in above existing numerical control systems. For the concrete implementation method, we use FPGA chip embedded with ARM hard nuclear processor to construct the control core of the motion controller. We also design the peripheral circuit of the controller according to the requirements of actual control functions, transplant real-time operating system into ARM, design the driver of the peripheral assisted chip, develop the application program to control and configuration of FPGA, design IP core of logic algorithm for various NC motion control to configured it into FPGA. The whole control system uses the concept of modular and structured design to develop hardware and software system. Thus the NC motion controller with the advantage of easily tailoring, highly opening, reconfigurable, and expandable can be implemented.

  7. Study of an NC system of machining crown gears

    NASA Astrophysics Data System (ADS)

    Xu, Xiaogang; Wang, Huaqing; Yan, Jian; Gao, Shenyou

    2005-12-01

    Crown gear couplings are usually used in metallurgy and steel rolling equipments, which is manufactured by duplicating processing in common. The method makes the manipulator work hard, and the efficiency is low. The machining precision is limited to the shape of the mold and it is difficult to control the movement of machines table. This work stated an NC system to use hobbing machine. It consists of an industrial control computer, grating sensor, servo- motor and its driver source, servo driver card and other I/O equipments of inputting and outputting. The grating sensor was installed in the axial direction to trace the instantaneous position of gob rest. The radial movement of the machine table was controlled by a servomotor. When the computer captures the axial signal, this system controls the machine table by moving ahead or backwards according to the calculated value of interpolation theory. Thus, two dimensions (axial and radial) associated movement was realized while the crown gear was processed. The feature of the system is that a grating sensor used in the axial direction replaces the servomotor. By making a little change in the mechanism of the machine, NC can be implement and its redesign cost is very low. The design software has an interpolation function for a circular arc and line. The system has been used on a Y1380 gear hobbing machine, and the correlative software of machining crown gear has been designed as well. Satisfactory results have been obtained, showing facility and reliability in practical operation.

  8. Analyzing dynamic characteristics of NC table with SVD

    NASA Astrophysics Data System (ADS)

    Wang, Linhong; Wu, Bo

    2008-12-01

    This article employs SVD (singular value decomposition) method to study dynamic characteristics of NC (numerical control) table. Acceleration signals of the NC table at three directions were tested; the singular spectrum of the signals was acquired with SVD; principal components of the signals were found out; the dynamic characteristics of the signals and its contributing factors were studied through extracting dynamic characteristics of principal components; and quantitative analysis was made on signals and principal components through calculating signal energy. The results indicated that signal characteristics of the previous two principal components are apparent, based on which dynamic characteristics of chaotic signal can be extracted; signal at perpendicular direction of table is greatly correlated with that at the horizontal moving direction, indicating that they are excited from the same vibration source. But signals perpendicular to each other in terms of moving direction at the horizontal level is rarely correlated; total signal energy is maximum at moving direction, minimum at horizontal non-moving direction and in the middle at perpendicular non-moving direction; bending vibration of lead screw at perpendicular direction is far more violent than that at horizontal direction.

  9. Kanamycin activates caspase-1 in NC/Nga mice.

    PubMed

    Han, Na-Ra; Kim, Hyung-Min; Jeong, Hyun-Ja

    2011-08-01

    Abuse of antibiotics to treat children has been associated with an increased risk of the development of inflammatory diseases. The underlying mechanism behind this association still remains to be clarified. Here, we examined the mechanisms behind kanamycin-induced skin inflammation in NC/Nga mice. NC/Nga mice were orally administered kanamycin for 7 days consecutively. Blood, spleen and dorsal skin were taken 18 weeks after kanamycin treatment was stopped. Kanamycin significantly increased the allergic reaction. We also observed significant increases in caspase-1 mRNA and protein expression in the dorsal skin of the kanamycin-administered mice compared to the control mice. The increased enzymatic activity of caspase-1 in the dorsal skin of the kanamycin-administered mice increased the mRNA expressions of IL-1β and IL-18. The productions of IL-1β and IL-18 were also increased in the splenocytes obtained from kanamycin-administered mice. Kanamycin upregulated the TNF-α mRNA expression in the dorsal skin and the TNF-α production in stimulated splenocytes. The activation of nuclear factor-κB and degradation of IκBα were increased by kanamycin administration. Our findings suggest that the use of kanamycin during infancy may increase the potential for skin inflammatory reactions through the upregulation of caspase-1.

  10. The Effect of Multiple Interface States and nc-Si Dots in a Nc-Si Floating Gate MOS Structure Measured by their G—V Characteristics

    NASA Astrophysics Data System (ADS)

    Shi, Yong; Ma, Zhong-Yuan; Chen, Kun-Ji; Jiang, Xiao-Fan; Li, Wei; Huang, Xin-Fan; Xu, Ling; Xu, Jun; Feng, Duan

    2013-07-01

    An nc-Si floating gate MOS structure is fabricated by thermal annealing of SiNx/a-Si/SiO2. There are nc-Si dots isolated by a-Si due to partial crystallization. Conductance-voltage (G—V) measurements are performed to investigate the effect of multiple interface states including Si-sub/SiO2, a-Si related (as-deposited sample) and nc-Si (annealed sample) in a charge trapping/releasing process. Double conductance peaks located in the depletion and weak inversion regions are found in our study. For the as-deposited sample, the Si-sub/SiO2 related G—V peak with weak intensity shifts to the negative as test frequency increases. The a-Si related G—V peak with strong intensity shifts slightly with the increasing frequency. For the annealed sample, little change appears in the intensity and shift of Si-sub/SiO2 related G—V peaks. The position of a-Si/nc-Si related peak is independent of frequency, and its intensity is weaker compared to that of the as-deposited sample. It is also found that as the size of nc-Si becomes larger, the a-Si/nc-Si related peak shifts to the depletion region due to the size effect of nc-Si.

  11. 75 FR 30706 - Safety Zone; Wilson Bay, Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... is necessary to provide for the safety of the general public and exercise participants from potential hazards associated with low flying helicopters and vessels participating in this multi agency exercise... conducting a multi agency exercise to test response capabilities of water rescue services in a mass...

  12. Numerical Control/Computer Aided Manufacturing (NC/CAM), A Descom Study

    DTIC Science & Technology

    1979-07-01

    question was asked if the programmer for the Punch Press (now being installed) would also program the NC Milling Machine (soon to be installed). The answer...NC Auto- matic Bar Chucker with a 16 inch owing, and a Punch Press with a Laser Cutting attachment be requested. Both appear to be justified, and...for NC Automatic Chucker (with 16 inch Swing), and a Punch Press with a Laser Cutting attachment. Include in earliest DE program year. g. Establish

  13. Chitosan silver nanocomposite (CAgNC) as an antifungal agent against Candida albicans.

    PubMed

    Kulatunga, Dcm; Dananjaya, Shs; Godahewa, G I; Lee, Jehee; De Zoysa, Mahanama

    2017-02-01

    Due to limited numbers of antifungal drugs and emergence of drug resistance have directed to develop nonconventional therapeutic agents against fungal pathogen Candida albicans. In this study, anticandidal activity of chitosan silver nanocomposite (CAgNC) was tested against C. albicans Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of CAgNC were determined as 25 and 100 μg/ml, respectively. Electron microscopic image results confirmed the ultrastructural cell wall deformities and injuries caused by CAgNC. Propidium iodide (PI) penetration into the CAgNC treated cells could be considered as an evidence for loss of cell membrane integrity and cell death at MFC. Level of intracellular reactive oxygen species (ROS) was increased, while cell viability was decreased with the increased of CAgNC concentrations. In our protein profile results, several induced proteins were observed under CAgNC treatment, and they could be related to multidrug and stress resistant proteins such as CDR1 (55 kDa) and CaHSP70 based on the protein band size. CAgNC mediated cell wall damage, loss of cell membrane integrity, elevated ROS level, and associated oxidative stress have been identified as the main causative factors for the anticandidal activity. Overall results from our study indicated that CAgNC could affect negatively on physiological and biochemical functions of C. albicans suggesting CAgNC as a potential alternative for antifungal chemotherapy.

  14. Characterizing ncRNAs in Human Pathogenic Protists Using High-Throughput Sequencing Technology

    PubMed Central

    Collins, Lesley Joan

    2011-01-01

    ncRNAs are key genes in many human diseases including cancer and viral infection, as well as providing critical functions in pathogenic organisms such as fungi, bacteria, viruses, and protists. Until now the identification and characterization of ncRNAs associated with disease has been slow or inaccurate requiring many years of testing to understand complicated RNA and protein gene relationships. High-throughput sequencing now offers the opportunity to characterize miRNAs, siRNAs, small nucleolar RNAs (snoRNAs), and long ncRNAs on a genomic scale, making it faster and easier to clarify how these ncRNAs contribute to the disease state. However, this technology is still relatively new, and ncRNA discovery is not an application of high priority for streamlined bioinformatics. Here we summarize background concepts and practical approaches for ncRNA analysis using high-throughput sequencing, and how it relates to understanding human disease. As a case study, we focus on the parasitic protists Giardia lamblia and Trichomonas vaginalis, where large evolutionary distance has meant difficulties in comparing ncRNAs with those from model eukaryotes. A combination of biological, computational, and sequencing approaches has enabled easier classification of ncRNA classes such as snoRNAs, but has also aided the identification of novel classes. It is hoped that a higher level of understanding of ncRNA expression and interaction may aid in the development of less harsh treatment for protist-based diseases. PMID:22303390

  15. A New Approach For FEM Simulation of NC Machining Processes

    NASA Astrophysics Data System (ADS)

    Wang, Sheng Ping; Padmanaban, Shivakumar

    2004-06-01

    The paper describes a new method for a finite element based pseudo-simulation of Numerically Controlled (NC) machining (material removal) processes. Industrial machining of a component usually results in warping or distortion due to the re-establishment of equilibrium in the retained part along with the relief of the insitu residual stresses in the removed part. In many cases, these distortions can be so large that the part may no longer be able to serve its designated functionality. Considering that the machining process is fundamentally a material removal process, a new method based on an automated removal of finite elements in the cutting area has been developed in the finite element analysis (FEA) software MSC.Marc to conduct pseudo-simulation of the NC machining process., A number of key software enhancements have been made to facilitate the pseudo-simulation of the NC machining process. First, a seamless interface has been developed to import APT/CL data generated by CAD/CAM systems. Then, the cutting paths have been generated based on information in the APT/CL files and used for the automatic detection of the intersection between the cutter and the finite element mesh. With each incremental motion of the cutter, the FEA solver detects all the elements that are located within the cutting path. Such elements are then deactivated in a step-by-step manner that is consistent with the actual machining process. In order to improve the fidelity of the cut area, local adaptive mesh refinement in the vicinity of the cutting tool is undertaken. This enables relatively coarser meshes away from the cut area and provides more accurate representation of the actual volume that is removed. As demonstrated by an industrial example, the enhanced software features in MSC.Marc have made it possible to practically and efficiently analyze complex machining processes of 3D production parts and provide an elegant tool for predicting distortions in large structures due to the relief

  16. The RNA infrastructure: an introduction to ncRNA networks.

    PubMed

    Collins, Lesley J

    2011-01-01

    The RNA infrastructure connects RNA-based functions. With transcription-to-translation processing forming the core of the network, we can visualise how RNA-based regulation, cleavage and modification are the backbone of cellular function. The key to interpreting the RNA-infrastructure is in understanding how core RNAs (tRNA, mRNA and rRNA) and other ncRNAs operate in a spatial-temporal manner, moving around the nucleus, cytoplasm and organelles during processing, or in response to environmental cues. This chapter summarises the concept of the RNA-infrastructure, and highlights examples of RNA-based networking within prokaryotes and eukaryotes. It describes how transcription-to-translation processes are tightly connected, and explores some similarities and differences between prokaryotic and eukaryotic RNA networking.

  17. Nucleon-nucleon interaction and large Nc QCD

    NASA Astrophysics Data System (ADS)

    Banerjee, Manoj K.; Cohen, Thomas D.; Gelman, Boris A.

    2002-03-01

    The nature of the nonrelativistic nucleon-nucleon potential in the large-Nc limit is discussed. In particular, we address the consistency of the meson-exchange picture of nucleon interactions. It is shown that the nonrelativistic nucleon-nucleon potential extracted from the Feynmann graphs up to and including two-meson-exchange diagrams satisfies the spin-flavor counting rules of Kaplan and Savage and of Kaplan and Manohar, provided the nucleon momenta is of order N0c. The key to this is a cancellation of the retardation effect of the box graphs against the contributions of the crossed-box diagram. The consistency requires including Δ as an intermediate state.

  18. NC2 mobilizes TBP on core promoter TATA boxes.

    PubMed

    Schluesche, Peter; Stelzer, Gertraud; Piaia, Elisa; Lamb, Don C; Meisterernst, Michael

    2007-12-01

    The general transcription factors (GTFs) of eukaryotic RNA polymerase II, in a process facilitated by regulatory and accessory factors, target promoters through synergistic interactions with core elements. The specific binding of the TATA box-binding protein (TBP) to the TATA box has led to the assumption that GTFs recognize promoters directly, producing a preinitiation complex at a defined position. Using biochemical analysis as well as biophysical single-pair Förster resonance energy transfer, we now provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode. This can lead to movement of TBP along the DNA away from TATA.

  19. Purification and genetic characterization of plantaricin NC8, a novel coculture-inducible two-peptide bacteriocin from Lactobacillus plantarum NC8.

    PubMed

    Maldonado, Antonio; Ruiz-Barba, José Luis; Jiménez-Díaz, Rufino

    2003-01-01

    A new, coculture-inducible two-peptide bacteriocin named plantaricin NC8 (PLNC8) was isolated from Lactobacillus plantarum NC8 cultures which had been induced with Lactococcus lactis MG1363 or Pediococcus pentosaceus FBB63. This bacteriocin consists of two distinct peptides, named alpha and beta, which were separated by C(2)-C(18) reverse-phase chromatography and whose complementary action is necessary for full plantaricin NC8 activity. N-terminal sequencing of both purified peptides showed 28 and 34 amino acids residues for PLNC8 alpha and PLNC8 beta, respectively, which showed no sequence similarity to other known bacteriocins. Mass spectrometry analysis showed molecular masses of 3,587 Da (alpha) and 4,000 Da (beta). The corresponding genes, designated plNC8A and plNC8B, were sequenced, and their nucleotide sequences revealed that both peptides are produced as bacteriocin precursors of 47 and 55 amino acids, respectively, which include N-terminal leader sequences of the double-glycine type. The mature alpha and beta peptides contain 29 and 34 amino acids, respectively. An open reading frame, orfC, which encodes a putative immunity protein was found downstream of plNC8B and overlapping plNC8A. Upstream of the putative -35 region of plNC8B, two direct repeats of 9 bp were identified, which agrees with the consensus sequence and structure of promoters of class II bacteriocin operons whose expression is dependent on an autoinduction mechanism.

  20. Purification and Genetic Characterization of Plantaricin NC8, a Novel Coculture-Inducible Two-Peptide Bacteriocin from Lactobacillus plantarum NC8

    PubMed Central

    Maldonado, Antonio; Ruiz-Barba, José Luis; Jiménez-Díaz, Rufino

    2003-01-01

    A new, coculture-inducible two-peptide bacteriocin named plantaricin NC8 (PLNC8) was isolated from Lactobacillus plantarum NC8 cultures which had been induced with Lactococcus lactis MG1363 or Pediococcus pentosaceus FBB63. This bacteriocin consists of two distinct peptides, named α and β, which were separated by C2-C18 reverse-phase chromatography and whose complementary action is necessary for full plantaricin NC8 activity. N-terminal sequencing of both purified peptides showed 28 and 34 amino acids residues for PLNC8α and PLNC8β, respectively, which showed no sequence similarity to other known bacteriocins. Mass spectrometry analysis showed molecular masses of 3,587 Da (α) and 4,000 Da (β). The corresponding genes, designated plNC8A and plNC8B, were sequenced, and their nucleotide sequences revealed that both peptides are produced as bacteriocin precursors of 47 and 55 amino acids, respectively, which include N-terminal leader sequences of the double-glycine type. The mature α and β peptides contain 29 and 34 amino acids, respectively. An open reading frame, orfC, which encodes a putative immunity protein was found downstream of plNC8B and overlapping plNC8A. Upstream of the putative −35 region of plNC8B, two direct repeats of 9 bp were identified, which agrees with the consensus sequence and structure of promoters of class II bacteriocin operons whose expression is dependent on an autoinduction mechanism. PMID:12514019

  1. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  2. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  3. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  4. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  5. 33 CFR 165.T05-0741 - Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Intracoastal Waterway; Carolina Beach, NC. 165.T05-0741 Section 165.T05-0741 Navigation and Navigable Waters... Guard District § 165.T05-0741 Safety Zone, Atlantic Intracoastal Waterway; Carolina Beach, NC. (a... Carolina Beach, North Carolina (34°03′21″ N, 077°53′58″ W). (b) Regulations. The general safety...

  6. 33 CFR 165.T05-1082 - Safety Zone; Atlantic Intracoastal Waterway, Wrightsville Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Intracoastal Waterway, Wrightsville Beach, NC. 165.T05-1082 Section 165.T05-1082 Navigation and Navigable... Coast Guard District § 165.T05-1082 Safety Zone; Atlantic Intracoastal Waterway, Wrightsville Beach, NC..., mile 283.1, at Wrightsville Beach, North Carolina (34°13′07″ N/077°48′46″ W). (b) Regulations....

  7. Anion-Dependent Aggregate Formation and Charge Behavior of Colloidal Fullerenes (n-C60)

    EPA Science Inventory

    The fate and transport of colloidal fullerenes (n-C60) in the environment is likely to be guided by electrokinetic and aggregation behavior. In natural water bodies inorganic ions exert significant effects in determining the size and charge of n-C60 nanoparticles. Although the ef...

  8. 76 FR 52291 - Proposed Amendment of Class E Airspace; Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Procedures have been developed at Albert J Ellis Airport. This action would enhance the safety and airspace... instrument approach procedures developed at Albert J Ellis Airport, Jacksonville, NC, and for continued... at Albert J Ellis Airport, Jacksonville, NC. Lists of Subjects in 14 CFR Part 71...

  9. 78 FR 9587 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... Cape Fear River Memorial Bridge, across the Cape Fear River, mile 26.8, at Wilmington, NC. The... second Sunday of November every year. The Cape Fear River Memorial Bridge, at mile 26.8, at...

  10. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  11. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  12. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  13. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  14. 33 CFR 165.530 - Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. 165.530 Section 165.530 Navigation and Navigable Waters COAST GUARD... § 165.530 Safety Zone: Cape Fear and Northeast Cape Fear Rivers, NC. (a) Location. The following area...

  15. 77 FR 51699 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC... operation of the Cape Fear River Memorial Bridge, at mile 26.8, over Cape Fear River, at Wilmington, NC. The... a.m. on the first or second Sunday of November every year. The Cape Fear River Memorial Bridge,...

  16. 77 FR 32394 - Drawbridge Operation Regulation; The Straights, Harkers Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; The Straights, Harkers Island, NC... operation of the Route 70/Harkers Island Bridge across The Straights, at Harkers Island, NC. The deviation...) owns and operates the swing span of the Route 70/Harkers Island Bridge across The Straights, in...

  17. 33 CFR 165.T05-0091 - Safety Zone; Alligator River, NC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Alligator River, NC... Safety Zone; Alligator River, NC. (a) Definitions. For the purposes of this section, Captain of the Port... on the waters of the Alligator River centered at (35°54′3″ N/076°00′25″ W) a position directly...

  18. NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases

    PubMed Central

    Wang, Jianjian; Cao, Yuze; Zhang, Huixue; Wang, Tianfeng; Tian, Qinghua; Lu, Xiaoyu; Lu, Xiaoyan; Kong, Xiaotong; Liu, Zhaojun; Wang, Ning; Zhang, Shuai; Ma, Heping; Ning, Shangwei; Wang, Lihua

    2017-01-01

    The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD–ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD–ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs. PMID:27899613

  19. NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.

    PubMed

    Wang, Jianjian; Cao, Yuze; Zhang, Huixue; Wang, Tianfeng; Tian, Qinghua; Lu, Xiaoyu; Lu, Xiaoyan; Kong, Xiaotong; Liu, Zhaojun; Wang, Ning; Zhang, Shuai; Ma, Heping; Ning, Shangwei; Wang, Lihua

    2017-01-04

    The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD-ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD-ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs.

  20. 33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a)...

  1. Role of the U(1) ghost beyond leading order in a large-Nc expansion

    SciTech Connect

    Hrayr Matevosyan; Anthony Thomas

    2008-09-01

    The 1/Nc expansion is one of the very few methods we have for generating a systematic expansion of QCD at the energy scale relevant to hadron structure. The present formulation of this theory relies on 't Hooft's double-line notation for calculating the leading order of a diagram in the 1/Nc expansion, where the local SU(Nc) gauge symmetry is substituted by a U(Nc) symmetry and the associated U(1) ghost field is ignored. In the current work we demonstrate the insufficiency of this formulation for describing certain non-planar diagrams. We derive a more complete set of Feynman rules that include the U(1) ghost field and provide a useful tool for calculating both color factors and 1/Nc orders of given color-singlet diagrams.

  2. Circulation on the Ebb Shoal at New River Inlet, NC

    NASA Astrophysics Data System (ADS)

    Raubenheimer, B.; Elgar, S.

    2012-12-01

    The effects of waves, winds, and tides on the spatially variable circulation (Fig. 1) on an ebb shoal offshore of New River Inlet, NC will be examined with observations collected in April and May 2012. Measurements of currents, waves, tides, and sea levels were obtained at 32 locations in the inlet and ebb shoal channels (2- to 10-m water depths) and across and offshore of the ebb shoal (1- to 5-m water depths). Maximum tidal flows in the inlet channel (onshore of the mouth) were +/- 1.5 m/s. In contrast, tidal flows 500 m offshore of the inlet mouth at the end of a channel recently dredged across the ebb shoal were stronger during ebbs (-1.5 m/s) than during floods (+0.5 m/s). Significant wave heights in 9-m water depth ranged from 0.5 to 2.5 m and wind speeds observed near the inlet mouth ranged from 0 to 14 m/s. Preliminary results suggest wave- and wind-forcing had a significant affect on the flows on the ebb shoal, especially during slack tides. The importance of setup gradients, wave-driven radiation stresses, and wind stresses to the circulation will be discussed. Funding was provided by ONR and NSSEFF. We thank David Clark, Danik Forsman, Levi Gorrell, Jeff Hansen, Sean Kilgallin, Christen Rivera, Jenna Walker, Regina Yopak, and Seth Zippel for helping obtain the data, personnel from the Army Corps of Engineers Field Research Facility for providing bathymetric surveys and excellent logistical support, and Jim Thomson for providing wind measurements.Figure 1: One-hour averaged ebb flow vectors (red arrows, scale on bottom right) at a low tide (pressure record shown at the bottom of the figure with a red dot indicating the time period) on May 6, 2012, at 03:00 EDT superposed on a Google Earth image of New River Inlet, NC. Offshore significant wave heights were about 0.5 m and winds were about 2 m/s from the north.

  3. Wave-driven fluxes through New River Inlet, NC

    NASA Astrophysics Data System (ADS)

    Wargula, A.; Raubenheimer, B.; Elgar, S.

    2012-12-01

    The importance of wave forcing to inlet circulation is examined using observations of waves, water levels, and currents collected in and near New River Inlet, NC during April and May, 2012. A boat-mounted system was used to measure current profiles along transects across the inlet mouth during three 14-hr periods, providing information on cross-inlet current structure, as well as discharge. Additionally, an array of 13 colocated pressure gages and profilers were deployed along 2 km of the inlet channel (5 to 10 m water depths) and ebb shoal channel (2 to 3 m water depths) and 19 colocated pressure gages and acoustic Doppler velocimeters were deployed across and offshore of the ebb shoal (1 to 5 m water depths) (Figure 1). The inlet is well mixed and tidal currents ranged from +/- 1.5 m/s, maximum discharge rates at peak ebb and flood were about 700 to 900 m3/s, offshore significant wave heights Hsig were 0.5 to 2.5 m, and wind speeds ranged from 0 to 14 m/s. Time-integrated residual discharge over semi-diurnal tidal cycles with similar ranges was ebb dominant during calm conditions (May 11, net out-of-inlet discharge ~ 55 m3, Hsig ~ 0.5 m, NW winds ~ 3 m/s) and flood dominant during stormier conditions (May 14, net into-inlet discharge ~ 15 m3, Hsig ~ 1.2 m, S winds ~ 6.5 m/s). Low-pass filtered in situ profiler data suggest wave-forcing affects the fluxes into and out of the inlet. The observations will be used to examine the momentum balance governing the temporal and cross-inlet (channel vs. shoal) variation of these fluxes, as well as the effect of waves on ebb and flood flow dominance. Funding provided by the Office of Naval Research and a National Security Science and Engineering Faculty Fellowship.; Figure 1: Google Earth image of New River Inlet, NC. Colors are depth contours (scale on the right, units are m relative to mean sea level) and symbols are locations of colocated current meters and pressure gages.

  4. Nc100668, a new tracer for imaging of venous thromboembolism: disposition and metabolism in rats.

    PubMed

    Skotland, Tore; Hustvedt, Svein Olaf; Oulie, Inger; Jacobsen, Petter Balke; Friisk, Grete Arneberg; Langøy, Ann Svendsen; Uran, Steinar; Sandosham, Jessie; Cuthbertson, Alan; Toft, Kim Gunnar

    2006-01-01

    The 99mTc-complex of NC100668 [Acetyl-Asn-Gln-Glu-Gln-Val-Ser-Pro-Tyr(3-iodo)-Thr-Leu-Leu-Lys-Gly-NC100194] is being evaluated for nuclear medical imaging of venous thromboembolism. NC100668 is a 13-amino acid peptide with a Tc-binding chelator [NC100194; -NH-CH2-CH2-N(CH2-CH2-NH-C(CH3)2-C(CH3)=N-OH)2] linked to the C-terminal end. Following injection in rats of [Asn-U-14C]NC100668 (labeling of the N-terminal amino acid), approximately 70% of the radioactivity was recovered in urine within 3 days. Following injection of [Lys-U-14C]NC100668 (labeling close to the C-terminal amino acid), radioactivity was cleared more slowly, with only 8% recovered in urine and approximately 80% of the radioactivity present in the body after 3 days. The highest concentration of radioactivity in the body following injection of [Lys-U-14C]NC100668 was observed in the kidney inner cortex; this probably represents 14C-labeled Lys, which is reabsorbed in the kidney tubules and incorporated into protein metabolism. Metabolite profiling by high-performance liquid chromatography with radiochemical detection revealed that following injection of [Asn-U-14C]NC100668, there is a rapid appearance in blood of one peak containing radioactive metabolite(s) originating from the N-terminal part of the molecule. In urine samples, only this radioactive peak was observed with no intact NC100668 remaining; this very hydrophilic N-terminal metabolite was probably either the N-terminal amino acid or a very short peptide. Liquid chromatography-mass spectrometry analyses of rat urine samples obtained after injection of nonlabeled NC100668 confirmed the identity of two metabolites generated from the C-terminal end of the molecule; Gly-NC100194 was identified as the major of these metabolites and NC100194 as a minor metabolite present at approximately one-tenth the amount of Gly-NC100194. No other metabolites were identified.

  5. The NC16A domain of collagen XVII plays a role in triple helix assembly and stability.

    PubMed

    Van den Bergh, Françoise; Fu, Chang-Ling; Olague-Marchan, Monica; Giudice, George J

    2006-12-01

    Collagen XVII/BP180 is a transmembrane constituent of the epidermal anchoring complex. To study the role of its non-collagenous linker domain, NC16A, in protein assembly and stability, we analyzed the following recombinant proteins: the collagen XVII extracellular domain with or without NC16A, and a pair of truncated proteins comprising the COL15-NC15 stretch expressed with or without NC16A. All four proteins were found to exist as stable collagen triple helices; however, the two missing NC16A exhibited melting temperatures significantly lower than their NC16A-containing counterparts. Protein refolding experiments revealed that the rate of triple helix assembly of the collagen model peptide GPP(10) is greatly increased by the addition of an upstream NC16A domain. In summary, the NC16A linker domain of collagen XVII exhibits a positive effect on both the rate of assembly and the stability of the adjoining collagen structure.

  6. 45 CFR 630.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... or agency. Federal agency or agency means any United States executive department, military department... (including the Executive Office of the President), or any independent regulatory agency....

  7. 41 CFR 105-74.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....645 Federal agency or agency. Federal agency or agency means any United States executive department... the executive branch (including the Executive Office of the President), or any independent...

  8. Production of plantaricin NC8 by Lactobacillus plantarum NC8 is induced in the presence of different types of gram-positive bacteria.

    PubMed

    Maldonado, Antonio; Ruiz-Barba, José Luis; Jiménez-Díaz, Rufino

    2004-01-01

    Lactobacillus plantarum NC8 was shown to produce plantaricin NC8 (PLNC8), a recently purified and genetically characterized inducible class IIb bacteriocin, only when it was co-cultured with other gram-positive bacteria. Among 82 strains belonging to the genera Bacillus, Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Listeria, Pediococcus, Staphylococcus, and Streptococcus, 41 were shown to induce PLNC8 production in L. plantarum NC8. There was apparently no relationship between the sensitivity of the strains and their ability to induce the bacteriocin, indicating that the inducer and sensitive phenotypes may not be linked. In some instances, induction was promoted by both living and heat-killed cells of the inducing bacteria. However, no PLNC8-inducing activity was found in the respective cell-free, pure culture supernatants. Inducer strains also promoted the production of a PLNC8-autoinducing activity by L. plantarum NC8, which was found only in the cell-free co-culture supernatants showing inhibitory activity. This PLNC8-autoinducing activity was diffusible, heat resistant, and of a proteinaceous nature, and was different from the bacteriocin itself. Taken together, the results suggest that the presence of specific gram-positive bacteria acts as an environmental stimulus activating both PLNC8 production by L. plantarum NC8 and a PLNC8-autoinducing activity, which in turn triggers or maintains bacteriocin production in the absence of inducing cells.

  9. 75 FR 16703 - Safety Zone; Wilson Bay, Jacksonville, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... safety zone is necessary to provide for the safety of the general public and exercise participants from... exercise. DATES: Comments and related material must be received by the Coast Guard on or before May 3, 2010... conducting a multi agency exercise to test response capabilities of water rescue services in a mass...

  10. Characterizing photochemical transformation of aqueous nC60 under environmentally relevant conditions.

    PubMed

    Hwang, Yu Sik; Li, Qilin

    2010-04-15

    Engineered nanomaterials may undergo transformation upon interactions with various environmental factors. In this study, photochemical transformation of aqueous nC60 was investigated under UVA irradiation. nC60 underwent photochemical transformation in the presence of dissolved O2, resulting in surface oxygenation and hydroxylation as demonstrated by XPS and ATR-FTIR analyses. The reaction followed a pseudo-first order rate law with the apparent reaction rate constant of 2.2 x 10(-2) h(-1). However, the core of the nanoparticles remained intact over 21 days of irradiation. Although no mineralization or dissolution of nC60 was observed, experiments using fullerol as a reference fullerene derivative suggested likely dissolution and partial mineralization of nC60 under long-term UVA exposure. Aquatic humic acid reduced nC60 transformation kinetics presumably due to scavenging of reactive oxygen species. Results from this study imply that photochemical transformation is an important factor controlling nC60 physical and chemical properties as well as its fate and transport in the natural aqueous environment. In addition, changes in nC60 surface chemistry drastically reduced C60 extraction efficiency by toluene, suggesting that the existing analytical method for C60 may not be applicable to environmental samples.

  11. Defect states in nc-Si:H films investigated by surface photovoltage spectroscopy

    SciTech Connect

    Cavalcoli, Daniela; Rossi, Marco; Cavallini, Anna

    2011-03-01

    Hydrogenated nanocrystalline silicon (nc-Si:H) is a multiphase, heterogeneous material, composed of Si nanocrystals embedded in an amorphous matrix. It has been intensively studied recently due to very promising photovoltaic and optoelectronics applications. The present paper aims to study electronic transitions in nc-Si:H grown by Low Energy Plasma Enhanced Chemical Vapor Deposition by Surface Photovoltage Spectroscopy. The study of several thin films grown at different conditions and the comparison with recently published computational studies allowed us to advance a hypothesis on the defect structure responsible for electronic transitions in nc-Si:H.

  12. Adoption of Evidence-Based Interventions in Local Health Departments: "1-2-3 Pap NC".

    PubMed

    Winterbauer, Nancy L; Bridger, Colleen M; Tucker, Ashley; Rafferty, Ann P; Luo, Huabin

    2015-08-01

    Descriptions of barriers and facilitators to adoption of evidence-based interventions in local health departments (LHDs) are limited. This study was conducted by the North Carolina Public Health Practice-Based Research Network to identify factors associated with adoption of an evidence-based human papillomavirus video intervention, "1-2-3 Pap NC," in North Carolina LHDs. A sequential mixed-method study design was used. Data from the 2013 National Profile of Local Health Departments were used to test associations between LHD characteristics and adoption of the intervention. Qualitative, key stakeholder interviews with LHD directors provided the context for quantitative data. Data collection and analysis continued from March 3, 2014, to September 15, 2014. Overall, 28% of North Carolina health jurisdictions (33 of 100 counties) implemented the intervention. Of the three channels used to deliver the intervention to clients, most LHDs opted to show the video in the exam room (42%), followed by website/other social media (36%) and video loop in the lobby/waiting room (22%). In logistic regression, gender of the director (female) was significantly and positively associated with adoption of the intervention (AOR=4.44, p<0.05). Being a first-time director was marginally significant (AOR=0.28, p=0.074), suggesting first-time directors were less likely to adopt. Qualitative results suggested that aspects of communication (awareness and positive attitudes) and agency directors' evaluation of resources, balanced against intervention complexity and flexibility, competing priorities, and mandates, influenced adoption. Adoption of evidence-based interventions by LHDs is critical to improve population health. Practice-based research can contribute to understanding facilitators and modifying barriers to this process.

  13. Sources of suspended sediment in the Lower Roanoke River, NC

    NASA Astrophysics Data System (ADS)

    Jalowska, A. M.; McKee, B. A.; Rodriguez, A. B.; Laceby, J. P.

    2015-12-01

    The Lower Roanoke River, NC, extends 220 km from the fall line to the bayhead delta front in the Albemarle Sound. The Lower Roanoke is almost completely disconnected from the upper reaches by a series of dams, with the furthest downstream dam located at the fall line. The dams effectively restrict the suspended sediment delivery from headwaters, making soils and sediments from the Lower Roanoke River basin, the sole source of suspended sediment. In flow-regulated rivers, bank erosion, especially mass wasting, is the major contributor to the suspended matter. Additional sources of the suspended sediment considered in this study are river channel, surface soils, floodplain surface sediments, and erosion of the delta front and prodelta. Here, we examine spatial and temporal variations in those sources. This study combined the use of flow and grain size data with a sediment fingerprinting method, to examine the contribution of surface and subsurface sediments to the observed suspended sediment load along the Lower Roanoke River. The fingerprinting method utilized radionuclide tracers 210Pb (natural atmospheric fallout), and 137Cs (produced by thermonuclear bomb testing). The contributions of surface and subsurface sources to the suspended sediment were calculated with 95% confidence intervals using a Monte-Carlo numerical mixing model. Our results show that with decreasing river slope and changing hydrography along the river, the contribution of surface sediments increases and becomes a main source of sediments in the Roanoke bayhead delta. At the river mouth, the surface sediment contribution decreases and is replaced by sediments eroded from the delta front and prodelta. The area of high surface sediment contribution is within the middle and upper parts of the delta, which are considered net depositional. Our study demonstrates that floodplains, often regarded to be a sediment sink, are also a sediment source, and they should be factored into sediment, carbon and

  14. 76 FR 53341 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... approximately 14 feet, above mean high water. On behalf of the City of New Bern NC, the National Multiple Sclerosis (MS) Society has requested a temporary deviation from the current operating regulations of...

  15. 75 FR 65513 - JELD-WEN Millwork Distribution, Wilkesboro, NC; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration JELD-WEN Millwork Distribution, Wilkesboro, NC; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated February 3, 2010, the...

  16. High Point, N.C., to Receive Federal Technical Assistance for Farmers Market

    EPA Pesticide Factsheets

    ATLANTA - High Point, N.C., has been selected as one of 27 rural communities across the country to participate in Local Foods, Local Places (LFLP), a federal initiative that helps increase economic opportunities for local farmers and related busines

  17. 75 FR 71463 - Woodland Mills Corporation Mill Spring, NC; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... Employment and Training Administration Woodland Mills Corporation Mill Spring, NC; Notice of Revised... of Woodland Mills Corporation, Mill Spring, North Carolina, to apply for Trade Adjustment Assistance... yarn produced by Woodland Mills Corporation, Mill Spring, North Carolina Woodland Mills...

  18. 75 FR 49524 - Woodland Mills Corporation, Mill Spring, NC; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Woodland Mills Corporation, Mill Spring, NC; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated July 22, 2010,...

  19. 75 FR 54023 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Camp Lejeune, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Lejeune, NC. The deviation is necessary to facilitate urgent replacement of the main hydraulic system... hydraulic system. Under this temporary deviation, the Onslow Beach Swing Bridge will be maintained in...

  20. Time-reversal-invariance-violating nucleon-nucleon potential in the 1 /Nc expansion

    NASA Astrophysics Data System (ADS)

    Samart, Daris; Schat, Carlos; Schindler, Matthias R.; Phillips, Daniel R.

    2016-08-01

    We apply the large-Nc expansion to the time-reversal-invariance-violating (TV) nucleon-nucleon potential. The operator structures contributing to next-to-next-to-leading order in the large-Nc counting are constructed. For the TV and parity-violating case we find a single operator structure at leading order. The TV but parity-conserving potential contains two leading-order terms, which, however, are suppressed by 1 /Nc compared to the parity-violating potential. Comparison with phenomenological potentials, including the chiral effective field theory potential in the TV parity-violating case, leads to large-Nc scaling relations for TV meson-nucleon and nucleon-nucleon couplings.

  1. Removal of aqueous nC60 fullerene from water by low pressure membrane filtration.

    PubMed

    Floris, R; Nijmeijer, K; Cornelissen, E R

    2016-03-15

    The potential environmental and health risks of engineered nanoparticles such as buckminsterfullerene C60 in water require their removal during the production of drinking water. We present a study focusing on (i) the removal mechanism and (ii) the elucidation of the role of the membrane pore size during removal of nC60 fullerene nanoparticle suspensions in dead-end microfiltration and ultrafiltration mimicking separation in real industrial water treatment plants. Membranes were selected with pore sizes ranging from 18 nm to 500 nm to determine the significance of the nC60 to membrane pore size ratio and the adsorption affinity between nC60 and membrane material during filtration. Experiments were carried out with a dead-end bench-scale system operated at constant flux conditions including a hydraulic backwash cleaning procedure. nC60 nanoparticles can be efficiently removed by low pressure membrane technology with smaller and, unexpectedly, also by mostly similar or larger pores than the particle size, although the nC60 filtration behaviour appeared to be different. The nC60 size to membrane pore size ratio and the ratio of the cake-layer deposition resistance to the clean membrane resistance, both play an important role on the nC60 filtration behaviour and on the efficiency of the backwash procedure recovering the initial membrane filtration conditions. These results become specifically significant in the context of drinking water production, for which they provide relevant information for an accurate selection between membrane processes and operational parameters for the removal of nC60 in the drinking water treatment.

  2. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  3. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  4. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost extremity to Cape Fear to latitude 33°49.5′ N. longitude 78°03.7′ W. (Cape Fear River Entrance Lighted...

  5. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost extremity to Cape Fear to latitude 33°49.5′ N. longitude 78°03.7′ W. (Cape Fear River Entrance Lighted...

  6. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  7. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  8. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost extremity to Cape Fear to latitude 33°49.5′ N. longitude 78°03.7′ W. (Cape Fear River Entrance Lighted...

  9. 46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2”...

  10. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost extremity to Cape Fear to latitude 33°49.5′ N. longitude 78°03.7′ W. (Cape Fear River Entrance Lighted...

  11. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost extremity to Cape Fear to latitude 33°49.5′ N. longitude 78°03.7′ W. (Cape Fear River Entrance Lighted...

  12. Heavy Baryons:. a Combined Large Nc and Heavy Quark Expansion for Electroweak Currents

    NASA Astrophysics Data System (ADS)

    Gelman, Boris A.

    2002-09-01

    The combined large Nc and heavy quark limit for baryons containing a single heavy quark is discussed. The combined large Nc and heavy quark expansion of the heavy quark bilinear operators is obtained. In this expansion, the corrections proportional to mN/mQ are summed to all orders. In particular, the expansion can be used to determine semileptonic form factors of heavy baryons in the combined limit.

  13. Engineering/Cost Evaluation of Options for Removal/Disposal of NC (nitrocellulose) Fines

    DTIC Science & Technology

    1987-09-30

    centrifugation for final concentration; e Incineration for disposal of NC sludge; and Alkaline digestion for pretreatment prior to biological treatment for...method for pretreatment I prior to biological treatment/disposal was involved with the majority of the most promising options. . Two of the three...centrifugation for final concentration; * Incineration for disposal of NC sludge; and * Alkaline digestion for pretreatment prior to biological treatment for

  14. 40 CFR 36.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Federal agency or agency. Federal agency or agency means any United States executive department, military... executive branch (including the Executive Office of the President), or any independent regulatory agency....

  15. Investigation of Gd3N@C2n (40 <= n <= 44) family by Raman and inelastic electron tunneling spectroscopy

    NASA Astrophysics Data System (ADS)

    Burke, Brian; Chan, Jack; Williams, Keith; Ge, Jiechao; Shu, Chunying; Fu, Wujun; Dorn, Harry; Kushmerick, James; Puretzky, Alexander; Geohegan, David

    2010-03-01

    The structure and vibrational spectrum of Gd3N@C80 is studied through Raman and inelastic electron tunneling spectroscopy (IETS) as well as density functional theory (DFT) and universal force field (UFF) calculations. Hindered rotations, shown by both theory and experiment, indicate the formation of a Gd3N-C80 bond which reduces the ideal icosahedral symmetry of the C80 cage. The vibrational modes involving the movement of the encapsulated species are a fingerprint of the interaction between the fullerene cage and the core complex. We present Raman data for the Gd3N@C2n (40 <= n <= 44) family as well as Y3N@C80, Lu3N@C80, and Y3N@C88 for comparison. Conductance measurements have been performed on Gd3N@C80 and reveal a Kondo effect similar to that observed in C60.

  16. Influence of implantation parameters on the depth distribution of emitting Si-nc

    NASA Astrophysics Data System (ADS)

    Dahmoune, C.; Barba, D.; Martin, F.; Ross, G. G.

    2012-02-01

    The photoluminescence (PL) spectra of silicon nanocrystals (Si-nc) produced by Si + implantation in SiO 2 are modulated by interference effects associated with the thickness of the SiO 2 layer and the depth where the Si-nc are situated. A model based on the Fresnel equation is used to determine the depth profile of emitting centers corresponding to the best fit between the calculated and measured integrated emission intensity of Si-nc for several thicknesses of SiO 2[1]. A parametric study has been performed for a range of implantation energy and excess Si concentration. The emitter depth profiles obtained with an excitation at 405 nm have greater amplitude and are generally wider than those pumped at 488 nm; this has been attributed to the excitation of larger band gap Si-nc. The shape of the emitter depth profiles generally agrees with those of implanted Si +, Si-nc and extinction coefficient. However, measurements performed using the 405 nm laser suggest that the emitter depth profiles produced with the large ion fluence of 1 × 10 17 cm -2 are deeper, a possible consequence of the strong damage incurred during implantation. Finally, when the local excess Si concentration exceeds the threshold required for the formation of large Si-nc (˜7 × 10 21 cm -3), saturation and, probably a decrease in emitter density is observed.

  17. A novel denitrifying methanotroph of the NC10 phylum and its microcolony.

    PubMed

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S M; Hu, Baolan

    2016-09-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species 'Candidatus Methylomirabilis oxyfera' (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it 'Candidatus Methylomirabilis sinica' (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7-1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25-0.5 × 0.8-1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies.

  18. A novel denitrifying methanotroph of the NC10 phylum and its microcolony

    PubMed Central

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S. M.; Hu, Baolan

    2016-01-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it ‘Candidatus Methylomirabilis sinica’ (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7–1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25–0.5 × 0.8–1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies. PMID:27582299

  19. A novel denitrifying methanotroph of the NC10 phylum and its microcolony

    NASA Astrophysics Data System (ADS)

    He, Zhanfei; Cai, Chaoyang; Wang, Jiaqi; Xu, Xinhua; Zheng, Ping; Jetten, Mike S. M.; Hu, Baolan

    2016-09-01

    The NC10 phylum is a candidate phylum of prokaryotes and is considered important in biogeochemical cycles and evolutionary history. NC10 members are as-yet-uncultured and are difficult to enrich, and our knowledge regarding this phylum is largely limited to the first species ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera). Here, we enriched NC10 members from paddy soil and obtained a novel species of the NC10 phylum that mediates the anaerobic oxidation of methane (AOM) coupled to nitrite reduction. By comparing the new 16S rRNA gene sequences with those already in the database, this new species was found to be widely distributed in various habitats in China. Therefore, we tentatively named it ‘Candidatus Methylomirabilis sinica’ (M. sinica). Cells of M. sinica are roughly coccus-shaped (0.7–1.2 μm), distinct from M. oxyfera (rod-shaped; 0.25–0.5 × 0.8–1.1 μm). Notably, microscopic inspections revealed that M. sinica grew in honeycomb-shaped microcolonies, which was the first discovery of microcolony of the NC10 phylum. This finding opens the possibility to isolate NC10 members using microcolony-dependent isolation strategies.

  20. Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature.

    PubMed

    Wright, Mathew W; Bruford, Elspeth A

    2011-01-01

    Previously, the majority of the human genome was thought to be 'junk' DNA with no functional purpose. Over the past decade, the field of RNA research has rapidly expanded, with a concomitant increase in the number of non-protein coding RNA (ncRNA) genes identified in this 'junk'. Many of the encoded ncRNAs have already been shown to be essential for a variety of vital functions, and this wealth of annotated human ncRNAs requires standardised naming in order to aid effective communication. The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 30,000 approved gene symbols currently listed in the HGNC database (http://www.genenames.org/search), the majority represent protein-coding genes; however, they also include pseudogenes, phenotypic loci and some genomic features. In recent years the list has also increased to include almost 3,000 named human ncRNA genes. HGNC is actively engaging with the RNA research community in order to provide unique symbols and names for each sequence that encodes an ncRNA. Most of the classical small ncRNA genes have now been provided with a unique nomenclature, and work on naming the long (>200 nucleotides) non-coding RNAs (lncRNAs) is ongoing.

  1. The baryon vector current in the combined chiral and 1/Nc expansions

    SciTech Connect

    Flores-Mendieta, Ruben; Goity, Jose L

    2014-12-01

    The baryon vector current is computed at one-loop order in large-Nc baryon chiral perturbation theory, where Nc is the number of colors. Loop graphs with octet and decuplet intermediate states are systematically incorporated into the analysis and the effects of the decuplet-octet mass difference and SU(3) flavor symmetry breaking are accounted for. There are large-Nc cancellations between different one-loop graphs as a consequence of the large-Nc spin-flavor symmetry of QCD baryons. The results are compared against the available experimental data through several fits in order to extract information about the unknown parameters. The large-Nc baryon chiral perturbation theory predictions are in very good agreement both with the expectations from the 1/Nc expansion and with the experimental data. The effect of SU(3) flavor symmetry breaking for the |Delta S|=1 vector current form factors f1(0) results in a reduction by a few percent with respect to the corresponding SU(3) symmetric values.

  2. The NC1 domain of type XIX collagen inhibits in vivo melanoma growth.

    PubMed

    Ramont, Laurent; Brassart-Pasco, Sylvie; Thevenard, Jessica; Deshorgue, Aurélie; Venteo, Lydie; Laronze, Jean Yves; Pluot, Michel; Monboisse, Jean-Claude; Maquart, François-Xavier

    2007-02-01

    Type XIX collagen is a minor collagen that localizes to basement membrane zones, together with types IV, XV, and XVIII collagens. Because several NC1 COOH-terminal domains of other chains from basement membrane collagens were reported to exhibit antitumor activity, we decided to study the effects of the NC1(XIX) collagen domain on tumor progression using an experimental in vivo model of mouse melanoma. We observed a 70% reduction in tumor volume in NC1(XIX)-treated mice compared with the corresponding controls. Histologic examination of the tumors showed a strong decrease in tumor vascularization in treated mice. In vitro, NC1(XIX) inhibited the migrating capacity of tumor cells and their capacity to invade Matrigel. It also inhibited the capacity of human microvascular endothelial cells to form pseudotubes in Matrigel. This effect was accompanied by a strong inhibition of membrane type-1 matrix metalloproteinase (matrix metalloproteinase-14) and vascular endothelial growth factor expression. Collectively, our data indicate that the NC1 domain of type XIX collagen exerts antitumor activity. This effect is mediated by a strong inhibition of the invasive capacities of tumor cells and antiangiogenic effects. NC1(XIX) should now be considered as a new member of the basement membrane collagen-derived matrikine family with antitumor and antiangiogenic activity.

  3. 78 FR 54947 - Notice of Final Federal Agency Actions on Proposed US 1 Improvements-Rockingham, Richmond County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... Hancock Street, Rockingham, North Carolina; Richmond County School System, 118 Vance Street, Hamlet, North... Carolina; and Richmond County Chamber of Commerce, 2 Main Street, Hamlet, North Carolina. This...

  4. Link between the potentially hazardous Asteroid (86039) 1999 NC43 and the Chelyabinsk meteoroid tenuous

    NASA Astrophysics Data System (ADS)

    Reddy, Vishnu; Vokrouhlický, David; Bottke, William F.; Pravec, Petr; Sanchez, Juan A.; Gary, Bruce L.; Klima, Rachel; Cloutis, Edward A.; Galád, Adrián; Guan, Tan Thiam; Hornoch, Kamil; Izawa, Matthew R. M.; Kušnirák, Peter; Le Corre, Lucille; Mann, Paul; Moskovitz, Nicholas; Skiff, Brian; Vraštil, Jan

    2015-05-01

    We explored the statistical and compositional link between Chelyabinsk meteoroid and potentially hazardous Asteroid (86039) 1999 NC43 to investigate their proposed relation proposed by Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237). First, using a slightly more detailed computation we confirm that the orbit of the Chelyabinsk impactor is anomalously close to the Asteroid 1999 NC43. We find ∼(1-3) × 10-4 likelihood of that to happen by chance. Taking the standpoint that the Chelyabinsk impactor indeed separated from 1999 NC43 by a cratering or rotational fission event, we run a forward probability calculation, which is an independent statistical test. However, we find this scenario is unlikely at the ∼(10-3-10-2) level. Secondly, we note that efforts to conclusively prove separation of the Chelyabinsk meteoroid from (86039) 1999 NC43 in the past needs to meet severe criteria: relative velocity ≃1-10 m/s or smaller, and ≃100 km distance (i.e. about the Hill sphere distance from the parent body). We conclude that, unless the separation event was an extremely recent event, these criteria present an insurmountable difficulty due to the combination of strong orbital chaoticity, orbit uncertainty and incompleteness of the dynamical model with respect to thermal accelerations. This situation leaves the link of the two bodies unresolved and calls for additional analyses. With that goal, we revisit the presumed compositional link between (86039) 1999 NC43 and the Chelyabinsk body. Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237) noted that given its Q-type taxonomic classification, 1999 NC43 may pass this test. However, here we find that while the Q-type classification of 1999 NC43 is accurate, assuming that all Q-types are LL chondrites is not. Our experiment shows that not all ordinary chondrites fall under Q-taxonomic type and not all LL chondrites are Q-types. Spectral curve matching between laboratory spectra of

  5. Guaranty Agency Questionnaire.

    ERIC Educational Resources Information Center

    Leifman, Steven

    The extent to which guaranty agencies, lenders, and state secondary markets impose restrictions on Guaranteed Student Loan (GSL) borrowing that go beyond federal regulations was assessed through a survey of 53 guaranty agencies. Seventeen of the agencies imposed restrictions on GSLs that go beyond federal regulations, including not loaning to…

  6. nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer

    PubMed Central

    Lee, Hyun-Sung; Lee, Ju-Seog; Park, Eun Jung; Choi, Sun Shim; Min, Jae Woong; Park, Daeyoon; Hwang, Jung-Ah; Johnson, Betty H.; Jeon, Sung Ho; Kim, In-Hoo; Lee, Yeon-Su; Lee, Yong Sun

    2016-01-01

    nc886 is a recently identified cellular non-coding RNA and its depletion leads to acute cell death via PKR (Protein Kinase RNA-activated) activation. nc886 expression is increased in some malignancies, but silenced in others. However, the precise role of nc886/PKR is controversial: is it a tumor suppressor or an oncogene? In this study, we have clarified the role of nc886 in thyroid cancer by sequentially generating PKR knockout (KO) and PKR/nc886 double KO cell lines from Nthy-ori 3-1, a partially transformed thyroid cell line. Compared to the wildtype, PKR KO alone does not exhibit any significant phenotypic changes. However, nc886 KO cells are less proliferative, migratory, and invasive than their parental PKR KO cells. Importantly, the requirement of nc886 in tumor phenotypes is totally independent of PKR. In our microarray data, nc886 KO suppresses some genes whose elevated expression is associated with poor survival confirmed by data from total of 505 thyroid cancer patients in the Caner Genome Atlas project. Also, the nc886 expression level tends to be elevated and in more aggressively metastatic tumor specimens from thyroid cancer patients. In summary, we have discovered nc886's tumor-promoting role in thyroid cancer which has been concealed by the PKR-mediated acute cell death. PMID:27612419

  7. Polarized photoluminescence of nc-Si–SiO{sub x} nanostructures

    SciTech Connect

    Michailovska, E. V.; Indutnyi, I. Z.; Shepeliavyi, P. E.; Sopinskii, N. V. E-mail: sopinskyy@ua.fm

    2016-01-15

    The effect of photoluminescence polarization memory in nc-Si–SiO{sub x} light-emitting structures containing Si nanoparticles (nc-Si) in an oxide matrix is for the first time studied. The polarization properties of continuous and porous nanostructures passivated in HF vapors (or solutions) are studied. It is established that the polarization memory effect is manifested only after treatment of the structures in HF. The effect is also accompanied by a shift of the photoluminescence peak to shorter wavelengths and by a substantial increase in the photoluminescence intensity. It is found that, in anisotropic nc-Si–SiO{sub x} samples produced by oblique deposition in vacuum, the degree of linear photoluminescence polarization in the sample plane exhibits a noticeable orientation dependence and correlates with the orientation of SiO{sub x} nanocolumns forming the structure of the porous layer. These effects are attributed to the transformation of symmetrically shaped Si nanoparticles into asymmetric elongated nc-Si particles upon etching in HF. In continuous layers, nc-Si particles are oriented randomly, whereas in porous structures, their preferential orientation coincides with the orientation of oxide nanocolumns.

  8. nC60 deposition kinetics: the complex contribution of humic acid, ion concentration, and valence.

    PubMed

    McNew, Coy P; LeBoeuf, Eugene J

    2016-07-01

    The demonstrated toxicity coupled with inevitable environmental release of nC60 raise serious concerns about its environmental fate and transport, therefore it is crucial to understand how nC60 will interact with subsurface materials including attached phase soil and sediment organic matter (AP-SOM). This study investigated the attachment of nC60 onto a Harpeth humic acid (HHA) coated silica surface under various solution conditions using a quartz crystal microbalance with dissipation monitoring. The HHA coating greatly enhanced nC60 attachment at low ion concentrations while hindering attachment at high ion concentrations in the presence of both mono and divalent cations. At low ion concentrations, the HHA greatly reduced the surface potential of the silica, enhancing nC60 deposition through reduction in the electrostatic repulsion. At high ion concentrations however, the reduced surface potential became less important due to the near zero energy barrier to deposition and therefore non-DLVO forces dominated, induced by compaction of the HHA layer, and leading to hindered attachment. In this manner, observed contributions from the HHA layer were more complex than previously reported and by monitoring surface charge and calculated DLVO interaction energy alongside attachment experiments, this study advances the mechanistic understanding of the variable attachment contributions from the humic acid layer.

  9. Noise in NC-AFM measurements with significant tip–sample interaction

    PubMed Central

    Lübbe, Jannis; Temmen, Matthias

    2016-01-01

    The frequency shift noise in non-contact atomic force microscopy (NC-AFM) imaging and spectroscopy consists of thermal noise and detection system noise with an additional contribution from amplitude noise if there are significant tip–sample interactions. The total noise power spectral density D Δ f(f m) is, however, not just the sum of these noise contributions. Instead its magnitude and spectral characteristics are determined by the strongly non-linear tip–sample interaction, by the coupling between the amplitude and tip–sample distance control loops of the NC-AFM system as well as by the characteristics of the phase locked loop (PLL) detector used for frequency demodulation. Here, we measure D Δ f(f m) for various NC-AFM parameter settings representing realistic measurement conditions and compare experimental data to simulations based on a model of the NC-AFM system that includes the tip–sample interaction. The good agreement between predicted and measured noise spectra confirms that the model covers the relevant noise contributions and interactions. Results yield a general understanding of noise generation and propagation in the NC-AFM and provide a quantitative prediction of noise for given experimental parameters. We derive strategies for noise-optimised imaging and spectroscopy and outline a full optimisation procedure for the instrumentation and control loops. PMID:28144538

  10. 22 CFR 312.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United States... other establishment in the executive branch (including the Executive Office of the President), or...

  11. 29 CFR 94.645 - Federal agency or agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Definitions § 94.645 Federal agency or agency. Federal agency or agency means any United States executive... establishment in the executive branch (including the Executive Office of the President), or any...

  12. 29 CFR 94.645 - Federal agency or agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ASSISTANCE) Definitions § 94.645 Federal agency or agency. Federal agency or agency means any United States... other establishment in the executive branch (including the Executive Office of the President), or...

  13. 22 CFR 312.645 - Federal agency or agency.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United States... other establishment in the executive branch (including the Executive Office of the President), or...

  14. 36 CFR 1212.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Definitions § 1212.645 Federal agency or agency. Federal agency or agency means any United States executive... establishment in the executive branch (including the Executive Office of the President), or any...

  15. 29 CFR 94.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ASSISTANCE) Definitions § 94.645 Federal agency or agency. Federal agency or agency means any United States... other establishment in the executive branch (including the Executive Office of the President), or...

  16. Large Nc deconfinement transition in the presence of a magnetic field

    NASA Astrophysics Data System (ADS)

    Fraga, Eduardo S.; Noronha, Jorge; Palhares, Letícia F.

    2013-06-01

    We investigate the effect of a homogeneous magnetic field on the thermal deconfinement transition of QCD in the large Nc limit. First we discuss how the critical temperature decreases due to the inclusion of Nf≪Nc flavors of massless quarks in comparison to the pure glue case. Then we study the equivalent correction in the presence of an external Abelian magnetic field. To leading order in Nf/Nc, the deconfinement critical temperature decreases with the magnetic field if the flavor contribution to the pressure behaves paramagnetically, with a sufficiently large magnetization as to overcome any possible magnetic effects in the string tension. Finally, we discuss the effects from a finite quark mass and its competition with magnetic effects.

  17. Fluorinated noble-gas cyanides FKrCN, FXeCN, and FXeNC

    SciTech Connect

    Zhu, Cheng; Räsänen, Markku; Khriachtchev, Leonid

    2015-08-21

    We report on three new noble-gas molecules, FKrCN, FXeCN, and FXeNC, prepared in low-temperature Kr and Xe matrices. These molecules are made by UV photolysis of FCN in the matrices and subsequent thermal annealing. The FCN precursor is produced by deposition of the matrix gas containing (FCN){sub 3} through a microwave discharge. The new noble-gas molecules are assigned with the help of quantum chemical calculations at the MP2(full) and CCSD(T) levels of theory. Similar Ar compounds (FArCN and FArNC) as well as FKrNC are not found in these experiments, which is in agreement with the calculated energetics.

  18. T cell participation in autoreactivity to NC16a epitopes in bullous pemphigoid

    PubMed Central

    Pickford, W J; Gudi, V; Haggart, A M; Lewis, B J; Herriot, R; Barker, R N; Ormerod, A D

    2015-01-01

    Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patients and 14 matched controls were tested for proliferative and cytokine responses to recombinant NC16a and a complete panel of 21 overlapping peptides spanning this region of BP180. Proliferative responses to NC16A and the peptide panel in the patients with active disease were similar in frequency and magnitude to those in healthy donors, and included late responses typical of naive cells in approximately 60% of each group. Interleukin (IL)-4 responses were slightly stronger for six peptides, and significantly stronger for Nc16a, in patients than in controls. Factor analysis identified factors that separate responses to the peptide panel discretely into IL-4, T helper type 2 (Th2) pattern, interferon (IFN)-γ, Th1 pattern and IL-10 or transforming growth factor [TGF-β, regulatory T cell (Treg)] pattern. Factors segregating IL-10 versus IFN-γ were predicted by active blistering or remission, and TGF-β or IL-10 versus IFN-γ by age. Finally, we confirmed a significant up-regulation of IgE responses to BP180 in the patients with pemphigoid. This shows the complexity of T cell phenotype and fine autoreactive specificity in responses to NC16A, in patients and in normal controls. Important disease-associated factors determine the balance of cytokine responses. Of these, specific IL-4 and IgE responses show the strongest associations with pemphigoid, pointing to an important contribution by Th2 cytokines to pathogenesis. PMID:25472480

  19. Identification of neuronal loci involved with displays of affective aggression in NC900 mice.

    PubMed

    Nehrenberg, Derrick L; Sheikh, Atif; Ghashghaei, H Troy

    2013-07-01

    Aggression is a complex behavior that is essential for survival. Of the various forms of aggression, impulsive violent displays without prior planning or deliberation are referred to as affective aggression. Affective aggression is thought to be caused by aberrant perceptions of, and consequent responses to, threat. Understanding the neuronal networks that regulate affective aggression is pivotal to development of novel approaches to treat chronic affective aggression. Here, we provide a detailed anatomical map of neuronal activity in the forebrain of two inbred lines of mice that were selected for low (NC100) and high (NC900) affective aggression. Attack behavior was induced in male NC900 mice by exposure to an unfamiliar male in a novel environment. Forebrain maps of c-Fos+ nuclei, which are surrogates for neuronal activity during behavior, were then generated and analyzed. NC100 males rarely exhibited affective aggression in response to the same stimulus, thus their forebrain c-Fos maps were utilized to identify unique patterns of neuronal activity in NC900s. Quantitative results indicated robust differences in the distribution patterns and densities of c-Fos+ nuclei in distinct thalamic, subthalamic, and amygdaloid nuclei, together with unique patterns of neuronal activity in the nucleus accumbens and the frontal cortices. Our findings implicate these areas as foci regulating differential behavioral responses to an unfamiliar male in NC900 mice when expressing affective aggression. Based on the highly conserved patterns of connections and organization of neuronal limbic structures from mice to humans, we speculate that neuronal activities in analogous networks may be disrupted in humans prone to maladaptive affective aggression.

  20. Contacts between influenza virus N9 neuraminidase and monoclonal antibody NC10.

    PubMed

    Lee, Janis T; Air, Gillian M

    2002-09-01

    We are interested in studying how influenza virus escapes antibody inhibition. Based on the structure of the complex between N9 NA and monoclonal antibody NC10 Fab (R. L. Malby, W. R. Tulip, V. R. Harley, J. L. McKimm-Breschkin, W. G. Laver, R. G. Webster, and P. M. Colman, 1994, Structure 2, 733-746), we investigated the contribution made by individual amino acids to the stability of the complex. We made conservative changes in residues that are centrally located in the epitope and more drastic changes in peripheral contacts. The mutations made were N200L (removing an N-linked oligosaccharide), N329Q, N345Q, S370T, S372A, N400L, and K432M. Binding of each mutant to NC10 was quantitated by NA inhibition assays and ELISA. Except for N200L and N329Q, the mutants were inhibited by NC10 to the same extent as wild-type NA although with less affinity. The enzyme activity (K(cat)) of N200L is 80% reduced, indicating a defect in folding or assembly; therefore, the loss in binding activity due to the missing sugar residue cannot be assessed. The K(d) for N329Q is sixfold higher than for wild-type NA in the inhibition test, but the same as wild-type in ELISA, indicating a change in disposition of the antibody but no loss of affinity. The results show that the NC10 epitope can accommodate a change at any site and is not dominated by a few high-energy interactions as was found in the NC41 epitope. We propose that the difference lies in the contribution of buried water molecules to the NA-NC10 complex.

  1. 34 CFR 84.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Federal agency or agency. 84.645 Section 84.645... WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.645 Federal agency or agency. Federal agency or agency.... 1082, 1094, 1221e-3 and 3474; and Sec. 2455, Pub. L. 103-355, 108 Stat. 3243 at 3327.)...

  2. 22 CFR 210.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Federal agency or agency. 210.645 Section 210.645 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 210.645 Federal agency or agency. Federal agency or...

  3. 22 CFR 210.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Federal agency or agency. 210.645 Section 210.645 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 210.645 Federal agency or agency. Federal agency or...

  4. 22 CFR 312.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Federal agency or agency. 312.645 Section 312.645 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United...

  5. 22 CFR 312.645 - Federal agency or agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Federal agency or agency. 312.645 Section 312.645 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United...

  6. 22 CFR 312.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Federal agency or agency. 312.645 Section 312.645 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.645 Federal agency or agency. Federal agency or agency means any United...

  7. Agency and intervention

    PubMed Central

    Roskies, Adina L.

    2015-01-01

    Novel ways to intervene on brain function raise questions about agency and responsibility. Here, I discuss whether direct brain interventions, and in particular, deep brain stimulation, pose a threat to agency in individual cases, or to our general conceptualization of what it is to be a responsible agent. While I do not currently see evidence that these interventions constitute a global challenge to our concept of agency, they do have the potential to diminish agency in individuals. I consider whether the lack of evidence for a global challenge ratifies our folk conceptions, or is a necessary consequence of them. In closing, I propose that our theoretical understanding of agency and our therapeutic approaches could be improved with a more nuanced, multidimensional view of agency. PMID:26240430

  8. Ab initio study on electronically excited states of lithium isocyanide, LiNC

    NASA Astrophysics Data System (ADS)

    Yasumatsu, Hisato; Jeung, Gwang-Hi

    2014-01-01

    The electronically excited states of the lithium isocyanide molecule, LiNC, were studied by means of ab initio calculations. The bonding nature of LiNC up to ∼10 eV is discussed on the basis of the potential energy surfaces according to the interaction between the ion-pair and covalent states. The ion-pair states are described by Coulomb attractive interaction in the long distance range, while the covalent ones are almost repulsive or bound with a very shallow potential dent. These two states interact each other to form adiabatic potential energy surfaces with non-monotonic change in the potential energy with the internuclear distance.

  9. Resonant raman scattering in complexes of nc-Si/SiO2 quantum dots and oligonucleotides

    NASA Astrophysics Data System (ADS)

    Bairamov, F. B.; Poloskin, E. D.; Kornev, A. A.; Chernev, A. L.; Toporov, V. V.; Dubina, M. V.; Röder, C.; Sprung, C.; Lipsanen, H.; Bairamov, B. Kh.

    2014-11-01

    We report on the functionalization of nanocrystalline nc-Si/SiO2 semiconductor quantum dots (QDs) by short d(20G, 20T) oligonucleotides. The obtained complexes have been studied by Raman spectroscopy techniques with high spectral and spatial resolution. A new phenomenon of multiband resonant light scattering on single oligonucleotide molecules has been discovered, and peculiarities of this effect related to the nonradiative transfer of photoexcitation from nc-Si/SiO2 quantum dots to d(20G, 20T) oligonucleotide molecules have been revealed.

  10. A Search for Neutrino Induced Coherent NC($\\pi^{0}$) Production in the MINOS Near Detector

    SciTech Connect

    Cherdack, Daniel David

    2011-02-01

    The production of single, highly forward π0 mesons by NC coherent neutrino-nucleus interactions (νμ + N → νμ + N + π0) is a process which probes fundamental aspects of the weak interaction. This reaction may also pose as a limiting background for long baseline searches for νμ → νe oscillations if the neutrino mixing angle θ13 is very small. The high-statistics sample of neutrino interactions recorded by the MINOS Near Detector provides an opportunity to measure the cross section of this coherent reaction on a relatively large-A nucleus at an average Ev = 4.9 GeV. A major challenge for this measurement is the isolation of forward-going electromagnetic (EM) showers produced by the relatively rare coherent NC0) process amidst an abundant rate of incoherently produced EM showers. The backgrounds arise from single π0 dominated NC events and also from quasi-elastic-like CC scattering of electron neutrinos. In this Thesis the theory of coherent interactions is summarized, and previous measurements of the coherent NC0) cross section are reviewed. Then, methods for selecting a sample of coherent NC0) like events, extracting the coherent NC0) event rate from that sample, estimating the analysis uncertainties, and calculating a cross section, are presented. A signal for neutrino-induced NC0) production is observed in the relevant kinematic regime as an excess of events of three standard deviations above background. The reaction cross sections, averaged over an energy window of 2.5 ≤ Ev ≤ 9.0 GeV is determined to be (31.6±10.5) x 10-40 cm2/nucleus. The result is the first evidence obtained for neutrino-nucleus coherent NC0) scattering on iron, and is the first measurement on an average nuclear target above A = 30. The cross section measurement

  11. Negotiating with Subscription Agencies.

    ERIC Educational Resources Information Center

    McQueen, Judy; Basch, N. Bernard

    1991-01-01

    This first in a two-part series on how librarians can negotiate services and prices with subscription agencies focuses on how vendors operate. Factors that influence agency costs, revenues, and service charges are described, including economies of scale, discounts from publishers, and prepayment and cash flow. (seven references) (LRW)

  12. Cranberry magnetite deposits Avery County, N.C., and Carter County, Tenn.

    USGS Publications Warehouse

    Kline, M.H.; Ballard, T.J.

    1948-01-01

    The Cranberry magnetite deposits occur in pre-Cambrian granite-gneiss in a belt extending from 3 miles southeast of Cranberry, N.C., to about 6 miles southwest of Magnetic City, Tenn. The belt forms a curve, elongated to the north, approximately 26 miles in length.

  13. 75 FR 15741 - Hickory Dyeing and Winding Co., Inc.: Hickory, NC; Notice of Termination of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Hickory Dyeing and Winding Co., Inc.: Hickory, NC; Notice of... workers of Hickory Dyeing and Winding Co., Inc., Hickory, North Carolina. The petitioner has...

  14. Pre-clinical results with Clariscan (NC100150 Injection); experience from different disease models.

    PubMed

    Bjørnerud, A; Johansson, L O; Ahlström, H K

    2001-05-01

    A superparamagnetic nanoparticle (NC100150 Injection) was investigated in two different animal models; renal perfusion in pigs and tumour imaging in mice. In the pig model, qualitative first-pass perfusion maps following a bolus injection of NC100150 Injection enabled good visualisation of hypoperfused regions of the renal cortex following partial ligation of the renal artery. High temporal resolution was found to be essential to accurately capture the first passage of the contrast agent through the kidney due to the very rapid blood flow in normal renal cortex. In the tumour model (LS174T cells implanted in nude mice), NC100150 Injection was found to cause a gradual (over 60 min) signal increase on T1-w images in part of the tumours which was attributed to contrast agent leakage from the vascular space to the extravascular space in areas of increased capillary permeability. This observation is consistent with previous reports on the molecular cut-off size for vascular extraction for this tumour cell line. The specific enhancement of tumour tissue suggest potential utility of NC100150 Injection as an angiogenesis marker.

  15. Numerical study of self modulation instability of 1 nC electron bunch at ATF

    SciTech Connect

    Fang Yun; Mori, Warren; Muggli, Patric

    2012-12-21

    The development of self-modulation instability (SMI) is investigated numerically for the 1 nC electron bunch available at Accelerator Test Facility (ATF) of Brookhaven National Laboratory (BNL). Possible experiment based on the simulation results is proposed. All the simulations are performed with the 2D-cylindrically symmetric particle-in-cell code.

  16. 76 FR 42542 - Special Local Regulations for Marine Events, Bogue Sound; Morehead City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... establishing Special Local Regulations for ``The Crystal Coast Grand Prix'' powerboat race, to be held on the... sponsor ``The Crystal Coast Grand Prix'' powerboat race on the waters of Bogue Sound adjacent to Morehead... Regulation; Crystal Coast Grand Prix; Morehead City, NC. (a) Regulated area. The following location is...

  17. 75 FR 54771 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Bridge Run. This deviation allows the drawbridge to be maintained in the closed position to vessels at... behalf of the Neuse River Bridge Run Organization and the City of New Bern NC, the North Carolina... the bridge set out in 33 CFR 117.843 (a) to accommodate the Bridge Run schedule for Saturday,...

  18. SITE CHARACTERIZATION OF A CHROMIUM SOURCE AREA AT THE USCG SUPPORT CENTER, ELIZABETH CITY, NC

    EPA Science Inventory

    The chrome source area is located beneath an old electroplating shop at the United States Coast Guard Support Center near Elizabeth City, NC . This electroplating shop was in
    use for approximately 30 years until 1984 and was the source of discharges of chromic and sulfuric...

  19. 78 FR 22195 - Safety Zone; Atlantic Intracoastal Waterway; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T05-1082 to read as follows: Sec. 165.T05-1082 Safety Zone; Atlantic Intracoastal Waterway, Wrightsville Beach, NC. (a..., Sec. 165.T05-1082. In addition the following regulations apply: (1) All vessels and persons...

  20. UV Irradiation and Humic Acid Mediate Aggregation of Aqueous Fullerene (nC60) Nanoparticles

    EPA Science Inventory

    The transport and fate of engineered nanomaterials is affected by multiple environmental factors, including sunlight and natural organic matter. In this study, the initial aggregation kinetics of aqueous fullerene (nC60) nanoparticles before and after UVA irradiation was investig...

  1. Single-molecule imaging reveals a switch between spurious and functional ncRNA transcription

    PubMed Central

    Lenstra, Tineke L.; Coulon, Antoine; Chow, Carson C.; Larson, Daniel R.

    2015-01-01

    Summary Eukaryotic transcription is pervasive, and many of the resulting RNAs are non-coding. It is unknown if ubiquitous transcription is functional or simply reflects stochastic transcriptional noise. By single-molecule visualization of the dynamic interplay between coding and non-coding transcription at the GAL locus in living yeast cells, we show that antisense GAL10 ncRNA transcription can switch between functional and spurious under different conditions. During galactose induction, GAL10 sense transcription occurs in short stochastic bursts which are unaffected by transcription of antisense GAL10 ncRNA, even when both are present simultaneously at the same locus. In contrast, when GAL10 is not induced, ncRNA transcription is critical to prevent transcriptional leakage of GAL1 and GAL10. Suppression of ncRNA transcription by strand-specific CRISPR/dCas9 results in transcriptional leakage of the inducer GAL1, leading to a more sensitive transcription activation threshold, an alteration of metabolic switching, and a fitness defect in competition experiments. PMID:26549684

  2. 76 FR 14695 - Jeld-Wen Millwork Distribution, Wilkesboro, NC; Notice of Negative Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... Employment and Training Administration Jeld-Wen Millwork Distribution, Wilkesboro, NC; Notice of Negative... Regarding Application for Reconsideration for workers and former workers of Jeld-Wen Millwork Distribution... reconsideration investigation confirmed that that the subject firm did not perform a service (such as...

  3. 78 FR 76784 - Proposed Modification, Revocation, and Establishment of Area Navigation (RNAV) Routes; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to establish two RNAV routes; modify three RNAV routes; and remove one RNAV route in the Charlotte, NC, area. The route changes are proposed to support the Charlotte Optimization of Airspace and Procedures in a Metroplex (OAPM) project. The proposed routes, in combination with existing VOR Federal airways, would provide additional routing options through and around the......

  4. The NC2 Domain of Collagen IX Provides Chain Selection and Heterotrimerization*

    PubMed Central

    Boudko, Sergei P.; Zientek, Keith D.; Vance, Jesse; Hacker, Jessica L.; Engel, Jürgen; Bächinger, Hans Peter

    2010-01-01

    The mechanism of chain selection and trimerization of fibril-associated collagens with interrupted triple helices (FACITs) differs from that of fibrillar collagens that have special C-propeptides. We recently showed that the second carboxyl-terminal non-collagenous domain (NC2) of homotrimeric collagen XIX forms a stable trimer and substantially stabilizes a collagen triple helix attached to either end. We then hypothesized a general trimerizing role for the NC2 domain in other FACITs. Here we analyzed the NC2 domain of human heterotrimeric collagen IX, the only member of FACITs with all three chains encoded by distinct genes. Upon oxidative folding of equimolar amounts of the α1, α2, and α3 chains of NC2, a stable heterotrimer with a disulfide bridge between α1 and α3 chains is formed. Our experiments show that this heterotrimerization domain can stabilize a short triple helix attached at the carboxyl-terminal end and allows for the proper oxidation of the cystine knot of type III collagen after the short triple helix. PMID:20507993

  5. 75 FR 7045 - Key Gas Components, Inc., Marion, NC; Notice of Negative Determination Regarding Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... Employment and Training Administration Key Gas Components, Inc., Marion, NC; Notice of Negative Determination... administrative reconsideration of the Department's negative determination regarding eligibility to apply for... of facts or of the law justified reconsideration of the decision. The negative determination of...

  6. Eta(') mass and chiral symmetry breaking at large N(c) and N(f).

    PubMed

    Girlanda, L; Stern, J; Talavera, P

    2001-06-25

    We propose a method for implementing the large- N(c), large-N(f) limit of QCD at the effective Lagrangian level. Depending on the value of the ratio N(f)/N(c), different patterns of chiral symmetry breaking can arise, leading in particular to different behaviors of the eta(') mass in the combined large-N limit.

  7. 77 FR 44463 - Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Emerald... establishing a temporary safety zone on the waters of the Atlantic Intracoastal Waterway at Emerald Isle, North... maintenance of the NC 58 Fixed Bridge crossing the Atlantic Intracoastal Waterway, mile 226, at Emerald...

  8. 77 FR 5186 - Drawbridge Operation Regulation; Northeast Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Northeast Cape Fear River, Wilmington... operation of the Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile 1.0, at Wilmington, NC... marine radio on channel 13 VHF. The Isabel S. Holmes Bridge across the Northeast Cape Fear River, mile...

  9. 77 FR 1406 - Drawbridge Operation Regulations; Northeast Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Northeast Cape Fear River... operation of the Isabel S. Holmes Bridge, mile 1.0, across the Northeast Cape Fear River, at Wilmington, NC... Northeast Cape Fear River. The drawbridge will be able to open in the event of an emergency. The Coast...

  10. 78 FR 5720 - Safety Zone, Atlantic Intracoastal Waterway; Oak Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    .... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add temporary Sec. 165.T05-1062 to read as follows: Sec. 165.T05-1062 Safety Zone; Atlantic Intracoastal Waterway, Oak Island, NC. (a...-1062. In addition the following regulations apply: (1) All vessels requiring greater than 50...

  11. 76 FR 66867 - Proposed Amendment of Class E Airspace; Rockingham, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... at Richmond County Airport. This action also would update the airport's geographic coordinates and note the name change to Richmond County Airport. This action would enhance the safety and airspace... at Richmond County Airport, Rockingham, NC. Airspace reconfiguration is necessary due to...

  12. 75 FR 54024 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... water. On behalf of the National Multiple Sclerosis (MS) Society and the City of New Bern NC, the North... Bern Ride and the City of New Bern Heritage Parade. Under this deviation, the drawbridge would be..., 2010 and Sunday, September 12, 2010, respectively; and for the City of New Bern Heritage Parade from...

  13. Connecting Green Space, Tree Cover, and Birth Outcomes in Durham-Chapel Hill, NC

    EPA Science Inventory

    Green space provides many ecosystem services relevant to human health. We investigated associations between green space, tree cover, and near-road tree cover with birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births occurring around Durham-Chapel Hill, NC,...

  14. Impacts of green space and tree cover on birth outcomes in Durham-Chapel Hill, NC

    EPA Science Inventory

    Ecosystem services affect human health through a variety of mechanisms. We investigated associations between green space and tree cover, and birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births in and around Durham-Chapel Hill, NC, between 1 January 2004 ...

  15. 75 FR 42 - Modification of Class D and E Airspace; Albemarle, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ... [Docket No. FAA-2009-0203; Airspace Docket No. 09-ASO-12] Modification of Class D and E Airspace... published in the Federal Register May 6, 2009, that modifies Class D and Class E airspace at Stanly County Airport, Albemarle, NC. This action also corrects the True bearing used in the Class D...

  16. 77 FR 44466 - Safety Zone, Atlantic Intracoastal Waterway; Oak Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Oak Island... temporary safety zone on the waters of the Atlantic Intracoastal Waterway at Oak Island, North Carolina. The... the NC 133 Fixed Bridge crossing the Atlantic Intracoastal Waterway, mile 311.8, at Oak Island,...

  17. 33 CFR 334.440 - New River, N.C., and vicinity; Marine Corps firing ranges.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... been published in the local notice to mariners and has been broadcast over the Marine Band radio...; Marine Corps firing ranges. 334.440 Section 334.440 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.C., and vicinity; Marine Corps firing ranges. (a) Atlantic Ocean east of New River Inlet....

  18. Anaerobic Oxidation of Methane Coupled to Nitrite Reduction by Halophilic Marine NC10 Bacteria

    PubMed Central

    He, Zhanfei; Geng, Sha; Cai, Chaoyang; Liu, Shuai; Liu, Yan; Pan, Yawei; Lou, Liping; Zheng, Ping; Xu, Xinhua

    2015-01-01

    Anaerobic oxidation of methane (AOM) coupled to nitrite reduction is a novel AOM process that is mediated by denitrifying methanotrophs. To date, enrichments of these denitrifying methanotrophs have been confined to freshwater systems; however, the recent findings of 16S rRNA and pmoA gene sequences in marine sediments suggest a possible occurrence of AOM coupled to nitrite reduction in marine systems. In this research, a marine denitrifying methanotrophic culture was obtained after 20 months of enrichment. Activity testing and quantitative PCR (qPCR) analysis were then conducted and showed that the methane oxidation activity and the number of NC10 bacteria increased correlatively during the enrichment period. 16S rRNA gene sequencing indicated that only bacteria in group A of the NC10 phylum were enriched and responsible for the resulting methane oxidation activity, although a diverse community of NC10 bacteria was harbored in the inoculum. Fluorescence in situ hybridization showed that NC10 bacteria were dominant in the enrichment culture after 20 months. The effect of salinity on the marine denitrifying methanotrophic culture was investigated, and the apparent optimal salinity was 20.5‰, which suggested that halophilic bacterial AOM coupled to nitrite reduction was obtained. Moreover, the apparent substrate affinity coefficients of the halophilic denitrifying methanotrophs were determined to be 9.8 ± 2.2 μM for methane and 8.7 ± 1.5 μM for nitrite. PMID:26048927

  19. 76 FR 12022 - Foreign-Trade Zone 230-Greensboro, NC; Application for Subzone; VF Jeanswear (Apparel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... (Apparel Distribution); Mocksville, NC An application has been submitted to the Foreign-Trade Zones Board... warehousing and distribution of foreign-origin apparel (duty rates 16.6%-28.6%) for the U.S. market and export... could exempt VF Jeanswear from customs duty payments on foreign apparel that is exported (about 1%...

  20. Scratching of their skin by NC/Nga mice leads to development of dermatitis.

    PubMed

    Hashimoto, Yuki; Arai, Iwao; Nakanishi, Yutaka; Sakurai, Takanobu; Nakamura, Atsushi; Nakaike, Shiro

    2004-12-31

    Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a therapeutic treatment by cutting off hind toenails of NC mice with severe dermatitis. In the preventive study, scratching behavior significantly increased in both WIT and WOT after dermatitis induction. Skin severity score, TEWL, number of mast cells and serum IgE concentration statistically increased in WIT but not in WOT after dermatitis induction. Histological changes coincided with the skin severity score in WIT, while no changes were observed in WOT. In the therapeutic study, skin severity score in WOT but not in WIT statistically decreased after cutting off the hind toenails. TEWL and numbers of mast cells in WOT were statistically lower compared with findings in WIT. Thus scratching up the skin with toenails seemed to be the most important factor leading to dermatitis in NC mice.

  1. 78 FR 13857 - Foreign-Trade Zone 93-Raleigh-Durham, NC; Authorization of Production Activity; Revlon Consumer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 93--Raleigh-Durham, NC; Authorization of Production Activity; Revlon Consumer Products Corporation (Hair Coloring Products); Oxford, NC On October 10, 2012,...

  2. Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells

    PubMed Central

    Mrázek, Jan; Kreutmayer, Simone B.; Grässer, Friedrich A.; Polacek, Norbert; Hüttenhofer, Alexander

    2007-01-01

    Non-protein-coding RNAs (ncRNAs) fulfill a wide range of cellular functions from protein synthesis to regulation of gene expression. Identification of novel regulatory ncRNAs by experimental approaches commonly includes the generation of specialized cDNA libraries encoding small ncRNA species. However, such identification is severely hampered by the presence of constitutively expressed and highly abundant ‘house-keeping’ ncRNAs, such as ribosomal RNAs, small nuclear RNAs or transfer RNAs. We have developed a novel experimental strategy, designated as subtractive hybridization of ncRNA transcripts (SHORT) to specifically select and amplify novel regulatory ncRNAs, which are only expressed at certain stages or under specific growth conditions of cells. The method is based on the selective subtractive hybridization technique, formerly applied to the detection of differentially expressed mRNAs. As a model system, we applied SHORT to Epstein–Barr virus (EBV) infected human B cells. Thereby, we identified 21 novel as well as previously reported ncRNA species to be up-regulated during virus infection. Our method will serve as a powerful tool to identify novel functional ncRNAs acting as genetic switches in the regulation of fundamental cellular processes such as development, tissue differentiation or disease. PMID:17478510

  3. 33 CFR 334.420 - Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., N.C.; danger zones for Marine Corps operations. 334.420 Section 334.420 Navigation and Navigable... REGULATIONS § 334.420 Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations. (a... date. Marine Corps Air Station Cherry Point will have a call-in number for public use to...

  4. Sulphur and oxygen sequestration of n-C37 and n-C38 unsaturated ketones in an immature kerogen and the release of their carbon skeletons during early stages of thermal maturation

    USGS Publications Warehouse

    Koopmans, M.P.; Schaeffer-Reiss, C.; De Leeuw, J. W.; Lewan, M.D.; Maxwell, J.R.; Schaeffer, P.; Sinninghe, Damste J.S.

    1997-01-01

    Sedimentary rock from the Gessoso-solfifera Formation (Messinian) in the Vena del Gesso Basin (northern Italy) containing immature (Ro = 0.25%) S-rich organic matter was artificially matured by hydrous pyrolysis at temperatures from 160 to 330??C for 72 h to study the diagenetic fate of n-C37 and n-C38 di-and tri-unsaturated methyl and ethyl ketones (alkenones) biosynthesised by several prymnesiophyte algae. During early diagenesis, the alkenones are incorporated into the kerogen by both sulphur and oxygen cross-linking as indicated by chemical degradation experiments with the kerogen of the unheated sample. Heating at temperatures between 160 and 260??C, which still represents early stages of thermal maturation, produces large amounts (up to 1 mg/g TOC) of S-bound, O-bound, and both S-and O-bound n-C37 and n-C38 skeletons, saturated n-C37 and n-C38 methyl, ethyl, and mid-chain ketones, C37 and C38 mid-chain 2,5-di-n-alkylthiophenes, C37 and C38 1,2-di-n-alkylbenzenes, and C37 and C38 n-alkanes. With increasing thermal maturation, three forms of the n-C37 and n-C38 skeletons are relatively stable (saturated hydrocarbons, 1,2-di-n-alkylbenzenes and saturated ketones), whereas the S-and O-bound skeletons are relatively labile. These results suggest that in natural situations saturated ketones with an n-C37 and n-C38 skeleton can be expected as well as the corresponding hydrocarbons. Copyright ?? 1997 Elsevier Science Ltd.

  5. Ground State Reactions of nC60 with Free Chlorine in Water.

    PubMed

    Wu, Jiewei; Benoit, Denise; Lee, Seung Soo; Li, Wenlu; Fortner, John D

    2016-01-19

    Facile, photoenhanced transformations of water-stable C60 aggregates (nC60) to oxidized, soluble fullerene derivatives, have been described as key processes in understanding the ultimate environmental fate of fullerene based materials. In contrast, fewer studies have evaluated the aqueous reactivity of nC60 during ground-state conditions (i.e., dark conditions). Herein, this study identifies and characterizes the physicochemical transformations of C60 (as nC60 suspensions) in the presence of free chlorine, a globally used chemical oxidant, in the absence of light under environmentally relevant conditions. Results show that nC60 undergoes significant oxidation in the presence of free chlorine and the oxidation reaction rates increase with free chlorine concentration while being inversely related to solution pH. Product characterization by FTIR, XPS, Raman Spectroscopy, TEM, XRD, TOC, collectively demonstrates that oxidized C60 derivatives are readily formed in the presence of free chlorine with extensive covalent oxygen and even chlorine additions, and behave as soft (or loose) clusters in solution. Aggregation kinetics, as a function of pH and ionic strength/type, show a significant increase in product stabilities for all cases evaluated, even at pH values approaching 1. As expected with increased (surface) oxidation, classic Kow partitioning studies indicate that product clusters are relatively more hydrophilic than parent (reactant) nC60. Taken together, this work highlights the importance of understanding nanomaterial reactivity and the identification of corresponding stable daughter products, which are likely to differ significantly from parent material properties and behaviors.

  6. Determination of dispersive optical constants of nanocrystalline CdSe (nc-CdSe) thin films

    SciTech Connect

    Sharma, Kriti; Al-Kabbi, Alaa S.; Saini, G.S.S.; Tripathi, S.K.

    2012-06-15

    Highlights: ► nc-CdSe thin films are prepared by thermal vacuum evaporation technique. ► TEM analysis shows NCs are spherical in shape. ► XRD reveals the hexagonal (wurtzite) crystal structure of nc-CdSe thin films. ► The direct optical bandgap of nc-CdSe is 2.25 eV in contrast to bulk (1.7 eV). ► Dispersion of refractive index is discussed in terms of Wemple–DiDomenico single oscillator model. -- Abstract: The nanocrystalline thin films of CdSe are prepared by thermal evaporation technique at room temperature. These thin films are characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and photoluminescence spectroscopy (PL). The transmission spectra are recorded in the transmission range 400–3300 nm for nc-CdSe thin films. Transmittance measurements are used to calculate the refractive index (n) and absorption coefficient (α) using Swanepoel's method. The optical band gap (E{sub g}{sup opt}) has been determined from the absorption coefficient values using Tauc's procedure. The optical constants such as extinction coefficient (k), real (ε{sub 1}) and imaginary (ε{sub 2}) dielectric constants, dielectric loss (tan δ), optical conductivity (σ{sub opt}), Urbach energy (E{sub u}) and steepness parameter (σ) are also calculated for nc-CdSe thin films. The normal dispersion of refractive index is described using Wemple–DiDomenico single-oscillator model. Refractive index dispersion is further analysed to calculate lattice dielectric constant (ε{sub L}).

  7. 22 CFR 1509.645 - Federal agency or agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or...

  8. 22 CFR 1509.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or...

  9. 22 CFR 1509.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or...

  10. 22 CFR 1509.645 - Federal agency or agency.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or...

  11. 22 CFR 1509.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Federal agency or agency. 1509.645 Section 1509.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.645 Federal agency or agency. Federal agency or...

  12. 28 CFR 83.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Federal agency or agency. 83.645 Section 83.645 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 83.645 Federal agency or agency. Federal agency or...

  13. Microstructural Properties of NC-Si/SiO2 Films IN SITU Grown by Reactive Magnetron Co-Sputtering

    NASA Astrophysics Data System (ADS)

    Lu, Wanbing; Guo, Shaogang; Wang, Jiantao; Li, Yun; Wang, Xinzhan; Yu, Gengxi; Fan, Shanshan; Fu, Guangsheng

    2012-01-01

    Nanocrystalline silicon embedded in silicon oxide (nc-Si/SiO2) films have been in situ grown at a low substrate temperature of 300°C by reactive magnetron co-sputtering of Si and SiO2 targets in a mixed Ar/H2 discharge. The influences of H2 flow rate (FH) on the microstructural properties of the deposited nc-Si/SiO2 films were investigated. The results of XRD and the deposition rate of nc-Si/SiO2 films show that the introduction of H2 contributes to the growth of nc-Si grains in silicon oxide matrix. With further increasing FH, the average size of nc-Si grains increases and the deposition rate of nc-Si/SiO2 films decreases gradually. Fourier transform infrared spectra analyses reveal that introduction of hydrogen contributes to the phase separation of nc-Si and SiOx in the deposited films. Moreover, the Si-O4-nSin(n = 0, 1) concentration of the deposited nc-Si/SiO2 films reduces with the increase of FH, while that of Si-O4-nSin(n = 2, 3) concentration increases. These results can be explained by that active hydrogen atoms increase the probability of reducing oxygen from precursor in the plasma and prompting oxygen desorption from the growing surface. This low-temperature procedure for preparing nc-Si/SiO2 films opens up the possibility of fabricating the silicon-based thin-film solar cells onto low-cost glass substrates using nc-Si/SiO2 films.

  14. Federal Emergency Management Agency

    MedlinePlus

    ... Updates Emergency Management Agencies Emergency Management Institute El Niño Environmental Planning and Historic Preservation Program Exercise Fact ... Local, State, Tribal and Non-Profit Recovery Resources Region I Region II Region III Region IV Region ...

  15. School Service Agency

    ERIC Educational Resources Information Center

    Leachen, Sylvia; Lipschitz, Beverly

    1970-01-01

    Describes school employment" agency to secure school jobs for interested students. They filled out applications, had interviews and secured recommendations. Program attempted to relieve hall congestion and improve tone of school. (Author/CJ)

  16. Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR.

    PubMed

    Calderon, Brenda M; Conn, Graeme L

    2017-04-01

    The double-stranded RNA (dsRNA)-activated protein kinase (PKR) senses dsRNA produced during viral infection and halts cellular protein synthesis to block viral replication. How basal PKR activity is controlled in the absence of infection was unclear until the recent identification of a potential endogenous regulator, the cellular noncoding RNA 886 (nc886). However, nc886 adopts two distinct conformations for which the structural details and potential functional differences remain unclear. Here, we isolated and separately dissected the function of each form of nc886 to more clearly define the molecular mechanism of nc886-mediated PKR inhibition. We show that nc886 adopts two stable, noninterconverting RNA conformers that are functionally nonequivalent using complementary RNA structure probing and mutational analyses combined with PKR binding and activity assays. One conformer acts as a potent inhibitor, while the other is a pseudoinhibitor capable of weakly activating the kinase. We mapped the nc886 region necessary for high affinity binding and potent inhibition of PKR to an apical stem-loop structure present in only one conformer of the RNA. This structural feature is not only critical for inhibiting PKR autophosphorylation, but also the phosphorylation of its cellular substrate, the eukaryotic translation initiation factor 2α subunit. The identification of different activities of the nc886 conformers suggests a potential mechanism for producing a gradient of PKR regulation within the cell and reveals a way by which a cellular noncoding RNA can mask or present a structural feature to PKR for inhibition.

  17. Comparison of community structures of Candidatus Methylomirabilis oxyfera-like bacteria of NC10 phylum in different freshwater habitats.

    PubMed

    Shen, Li-Dong; Wu, Hong-Sheng; Gao, Zhi-Qiu; Liu, Xu; Li, Ji

    2016-05-09

    Methane oxidation coupled to nitrite reduction is mediated by 'Candidatus Methylomirabilis oxyfera' (M. oxyfera), which belongs to the NC10 phylum. In this study, the community composition and diversity of M. oxyfera-like bacteria of NC10 phylum were examined and compared in four different freshwater habitats, including reservoir sediments (RS), pond sediments (PS), wetland sediments (WS) and paddy soils (PAS), by using Illumina-based 16S rRNA gene sequencing. The recovered NC10-related sequences accounted for 0.4-2.5% of the 16S rRNA pool in the examined habitats, and the highest percentage was found in WS. The diversity of NC10 bacteria were the highest in RS, medium in WS, and lowest in PS and PAS. The observed number of OTUs (operational taxonomic unit; at 3% cut-off) were 97, 46, 61 and 40, respectively, in RS, PS, WS and PAS. A heterogeneous distribution of NC10 bacterial communities was observed in the examined habitats, though group B members were the dominant bacteria in each habitat. The copy numbers of NC10 bacterial 16S rRNA genes ranged between 5.8 × 10(6) and 3.2 × 10(7) copies g(-1) sediment/soil in the examined habitats. These results are helpful for a systematic understanding of NC10 bacterial communities in different types of freshwater habitats.

  18. Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts

    PubMed Central

    Kudo, Masahisa; Yamamoto, Yoshiyuki; Koga, Yoshikatsu; Hamaguchi, Tetsuya; Akimoto, Tetsuo; Yasunaga, Masahiro; Matsumura, Yasuhiro

    2016-01-01

    Combination therapy with S-1 and cisplatin (CDDP) is the standard chemotherapy for advanced gastric cancer in Japan; however, its administration requires hospitalization for hydration to prevent nephrotoxicity from CDDP. By contrast, NC-6004 appears to reduce the renal toxicity of CDDP and may be used on an outpatient basis. Thus, the effects of combined treatment with S-1 and NC-6004 were compared with those of S-1 and CDDP in a human gastric cancer model. In vitro cytotoxic effects were investigated in 44As3Luc, MKN45 and MKN74 human gastric cancer cell lines. The effects of NC-6004 and 5-fluorouracil (5-FU) were compared with the effects of CDDP and 5-FU using the combination index method. The in vivo antitumor effects of S-1/NC-6004 and S-1/CDDP were evaluated in mice bearing 44As3Luc xenografts. Both combinations exhibited synergistic activity in MKN45 and MKN74 cells and additive effects in 44As3Luc cells. Moreover, the in vivo antitumor effects did not differ between the S-1/NC-6004 and S-1/CDDP treatment groups. However, a significantly lower body weight loss was observed in S-1/NC-6004-treated mice compared with the S-1/CDDP-treated mice. Our data warrant a clinical evaluation of S-1/NC-6004 combination therapy. PMID:28101359

  19. Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts.

    PubMed

    Kudo, Masahisa; Yamamoto, Yoshiyuki; Koga, Yoshikatsu; Hamaguchi, Tetsuya; Akimoto, Tetsuo; Yasunaga, Masahiro; Matsumura, Yasuhiro

    2016-12-01

    Combination therapy with S-1 and cisplatin (CDDP) is the standard chemotherapy for advanced gastric cancer in Japan; however, its administration requires hospitalization for hydration to prevent nephrotoxicity from CDDP. By contrast, NC-6004 appears to reduce the renal toxicity of CDDP and may be used on an outpatient basis. Thus, the effects of combined treatment with S-1 and NC-6004 were compared with those of S-1 and CDDP in a human gastric cancer model. In vitro cytotoxic effects were investigated in 44As3Luc, MKN45 and MKN74 human gastric cancer cell lines. The effects of NC-6004 and 5-fluorouracil (5-FU) were compared with the effects of CDDP and 5-FU using the combination index method. The in vivo antitumor effects of S-1/NC-6004 and S-1/CDDP were evaluated in mice bearing 44As3Luc xenografts. Both combinations exhibited synergistic activity in MKN45 and MKN74 cells and additive effects in 44As3Luc cells. Moreover, the in vivo antitumor effects did not differ between the S-1/NC-6004 and S-1/CDDP treatment groups. However, a significantly lower body weight loss was observed in S-1/NC-6004-treated mice compared with the S-1/CDDP-treated mice. Our data warrant a clinical evaluation of S-1/NC-6004 combination therapy.

  20. Comparison of community structures of Candidatus Methylomirabilis oxyfera-like bacteria of NC10 phylum in different freshwater habitats

    PubMed Central

    Shen, Li-dong; Wu, Hong-sheng; Gao, Zhi-qiu; Liu, Xu; Li, Ji

    2016-01-01

    Methane oxidation coupled to nitrite reduction is mediated by ‘Candidatus Methylomirabilis oxyfera’ (M. oxyfera), which belongs to the NC10 phylum. In this study, the community composition and diversity of M. oxyfera-like bacteria of NC10 phylum were examined and compared in four different freshwater habitats, including reservoir sediments (RS), pond sediments (PS), wetland sediments (WS) and paddy soils (PAS), by using Illumina-based 16S rRNA gene sequencing. The recovered NC10-related sequences accounted for 0.4–2.5% of the 16S rRNA pool in the examined habitats, and the highest percentage was found in WS. The diversity of NC10 bacteria were the highest in RS, medium in WS, and lowest in PS and PAS. The observed number of OTUs (operational taxonomic unit; at 3% cut-off) were 97, 46, 61 and 40, respectively, in RS, PS, WS and PAS. A heterogeneous distribution of NC10 bacterial communities was observed in the examined habitats, though group B members were the dominant bacteria in each habitat. The copy numbers of NC10 bacterial 16S rRNA genes ranged between 5.8 × 106 and 3.2 × 107 copies g−1 sediment/soil in the examined habitats. These results are helpful for a systematic understanding of NC10 bacterial communities in different types of freshwater habitats. PMID:27157928

  1. Light shift from ultraviolet to near infrared light: Cerenkov luminescence with gold nanocluster - near infrared (AuNc-NIR) conjugates

    NASA Astrophysics Data System (ADS)

    Yoo, Su Woong; Mun, Hyoyoung; Oh, Gyungseok; Ryu, Youngjae; Kim, Min-Gon; Chung, Euiheon

    2015-03-01

    Cerenkov luminescence (CL) is generated when a charged particle moves faster than the speed of light in dielectric media. Recently CL imaging becomes an emerging technique with the use of radioisotopes. However, due to relatively weak blue light production and massive tissue attenuation, CL has not been applied widely. Therefore, we attempted to shift the CL emission to more near infrared (NIR) spectrum for better tissue penetration by using Cerenkov Radiation Energy Transfer (CRET). Gold nanoclusters were conjugated with NIR dye molecules (AuNc-IR820 and AuNc-ICG) to be activated with ultraviolet light. We found optimal conjugate concentrations of AuNc-NIR conjugates by spectroscopy system to generate maximal photon emission. When exposed by ultraviolet light, the emission of NIR light from the conjugates were verified. In quantitative analysis, AuNc-NIR conjugates emit brighter light signal than pure AuNc. This result implies that NIR fluorescent dyes (both IR820 and ICG) can be excited by the emission from AuNc. Following the above baseline experiment, we mixed F-18 fluorodeoxyglucose (F-18 FDG) radioisotope to the AuNc- NIR conjugates, to confirm NIR emission induced from Cerenkov radiation. Long pass filter was used to block Cerenkov luminescence and to collect the emission from AuNc-NIR conjugates. Instead of one long exposure imaging with CCD, we used multiple frame scheme to eliminate gamma radiation strike in each frame prior to combination. In summary, we obtained NIR emission light from AuNc-NIR conjugated dyes that is induced from CL. We plan to perform in vivo small animal imaging with these conjugates to assess better tissue penetration.

  2. Integrated CAD/CAM/CNC system based on STEP-NC and intelligent manufacturing

    NASA Astrophysics Data System (ADS)

    Du, Juan; Tian, Xitian; Zhang, Zhenming; Xu, Jianxin; Zhu, Mingquan

    2005-12-01

    In order to realize bi-direction exchange of information and knowledge sharing between CAD/CAM systems and CNC machines, a method of information integration was proposed based on process data model and STEP-NC neutral file. A frame of integrated CAD/CAM/CNC systems was established, and the key integration techniques including process data modeling based on XML form and automatic feature recognition were studied. Since the STEP-NC based CNC (STEP- CNC) system can undertake various intelligent functions that cannot be performed by the conventional CNC based on ISO 6983, the intelligent manufacturing functions of STEP- CNC system was also discussed. The presented methodology combining with the modern net and communication technologies provides an effective means for developing intelligent, integrated manufacturing systems for the 21 century.

  3. Analysis of 56-plet Positive Parity Baryon Decays in the 1/Nc Expansion

    SciTech Connect

    Jose Goity, Norberto Scoccola, Chandana Jayalath

    2009-10-01

    The partial decay widths of positive parity baryons belonging to 56-plets of SU(6) are analyzed in the framework of the 1/Nc expansion. The channels considered are those with emission of a single pion, K or K-bar mesons, and the analysis is carried out to subleading order in 1/Nc and to first order in SU(3) symmetry breaking. The results for the multiplet [56,0+], to which the Roper resonance belongs, indicate a poor description at leading order, requiring large next to leading order corrections. For the multiplet [56,2+], the P-wave decays in the non-strange sector are well described at leading order and important SU(3) breaking corrections are necessary to describe transitions involving strangeness, on the other hand, the F-wave decays require the next to leading order corrections, which turn out to be however of natural magnitude.

  4. The NC2 domain of type IX collagen determines the chain register of the triple helix.

    PubMed

    Boudko, Sergei P; Bächinger, Hans Peter

    2012-12-28

    Precise mapping and unraveling the mechanism of interaction or degradation of a certain type of collagen triple helix requires the generation of short and stable collagenous fragments. This is a great challenge especially for hetero-trimeric collagens, where chain composition and register (stagger) are important factors. No system has been reported that can be efficiently used to generate a natural collagenous fragment with exact chain composition and desired chain register. The NC2 domain (only 35-50 residues) of FACIT collagens is a potent trimerization domain. In the case of type IX collagen it provides the efficient selection and hetero-trimerization of three distinct chains. The ability of the NC2 domain to determine the chain register of the triple helix is studied. We generated three possible sequence combinations (α1α1α2, α1α2α1, α2α1α1) of a type I collagen fragment (the binding region for the von Willebrand factor A3 domain) attached to the NC2 domain. In addition, two control combinations were produced that constitute homo-trimers of (α1)(3) or (α2)(3). For the hetero-trimeric constructs, α1α1α2 demonstrated a higher melting temperature than the other two. Binding experiments with the von Willebrand factor A3 domain revealed the homo-trimer of (α1)(3) as the strongest binding construct, whereas the homo-trimer of (α2)(3) showed no binding. For hetero-trimers, α1α1α2 was found to be the strongest binding construct. Differences in thermal stability and binding to the A3 domain unambiguously demonstrate that the NC2 domain of type IX collagen determines not only the chain composition but also the chain register of the adjacent triple helix.

  5. A study of diamond synthesis by hot filament chemical vapor deposition on Nc coatings

    NASA Astrophysics Data System (ADS)

    Polini, R.; Kumashiro, S.; Jackson, M. J.; Amar, M.; Ahmed, W.; Sein, H.

    2006-04-01

    Deposition of diamond films onto various substrates can result in significant technological advantages in terms of functionality and improved life and performance of components. Diamond is hard, wear resistant, chemically inert, and biocompatible. It is considered to be the ideal material for surfaces of cutting tools and biomedical components. However, it is well known that diamond deposition onto technologically important substrates, such as co-cemented carbides and steels, is problematic due to carbon interaction with the substrate, low nucleation densities, and poor adhesion. Several papers previously published in the relevant literature have reported the application of interlayer materials such as metal nitrides and carbides to provide bonding between diamond and hostile substrates. In this study, the chemical vapor deposition (CVD) of polycrystalline diamond on TiN/SiN x nc (nc) interlayers deposited at relatively low temperatures has been investigated for the first time. The nc layers were deposited at 70 or 400 °C on Si substrates using a dual ion beam deposition system. The results showed that a preliminary seeding pretreatment with diamond suspension was necessary to achieve large diamond nucleation densities and that diamond nucleation was larger on nc films than on bare sc-Si subjected to the same pretreatment and CVD process parameters. TiN/SiN x layers synthesized at 70 or 400 °C underwent different nanostructure modifications during diamond CVD. The data also showed that TiN/SiN x films obtained at 400 °C are preferable in so far as their use as interlayers between hostile substrates and CVD diamond is concerned.

  6. Mixed enrichment core design for the NC State University PULSTAR Reactor

    SciTech Connect

    Mayo, C.W.; Verghese, K.; Huo, Y.G.

    1997-12-01

    The North Carolina State University PULSTAR Reactor license was renewed for an additional 20 years of operation on April 30, 1997. The relicensing period added additional years to the facility operating time through the end of the second license period, increasing the excess reactivity needs as projected in 1988. In 1995, the Nuclear Reactor Program developed a strategic plan that addressed the future maintenance, development, and utilization of the facility. Goals resulting from this plan included increased academic utilization of the facility in accordance with its role as a university research facility, and increased industrial service use in accordance with the mission of a land grant university. The strategic plan was accepted, and it is the intent of the College of Engineering to operate the PULSTAR Reactor as a going concern through at least the end of the current license period. In order to reach the next relicensing review without prejudice due to low excess reactivity, it is desired to maintain sufficient excess reactivity so that, if relicensed again, the facility could continue to operate without affecting users until new fuel assistance was provided. During the NC State University license renewal, the operation of the PULSTAR Reactor at the State University of New York at Buffalo (SUNY Buffalo) was terminated. At that time, the SUNY Buffalo facility had about 240 unused PULSTAR Reactor fuel pins with 6% enrichment. The objective of the work reported here was to develop a mixed enrichment core design for the NC State University PULSTAR reactor which would: (1) demonstrate that 6% enriched SUNY buffalo fuel could be used in the NC State University PULSTAR Reactor within the existing technical specification safety limits for core physics parameters; (2) show that use of this fuel could permit operating the NC State University PULSTAR Reactor to 2017 with increased utilization; and (3) assure that the decision whether or not to relicense the facility would

  7. NC3A Simulation Support for NATO Exercise Clean Hunter 2001

    DTIC Science & Technology

    2002-06-01

    system which forwarded launch and impact warnings throughout NATO using the secure wide area network (WAN) CRONOS and the Integrated Command and...TRACKS LAUNCH MESSAGE AND MISSILE TRACKS AGS CUE JOIIS 404 JTMDC DATA SATCOM ADSI-SAT COM VOICE WOTS - TIBS STAND ALONE X 2 CRONOS TMD CH ICC...SHARED) CRONOS A2 SEW AWARE ICC A2 TGT CRONOS A2 ASS AWARE AGS EXPLOIT GALE CRONOS OPS LIAS AGS EXPLOIT AGS EXPLOIT NC3A Simulation Support

  8. Bayesian reliability modeling and assessment solution for NC machine tools under small-sample data

    NASA Astrophysics Data System (ADS)

    Yang, Zhaojun; Kan, Yingnan; Chen, Fei; Xu, Binbin; Chen, Chuanhai; Yang, Chuangui

    2015-11-01

    Although Markov chain Monte Carlo(MCMC) algorithms are accurate, many factors may cause instability when they are utilized in reliability analysis; such instability makes these algorithms unsuitable for widespread engineering applications. Thus, a reliability modeling and assessment solution aimed at small-sample data of numerical control(NC) machine tools is proposed on the basis of Bayes theories. An expert-judgment process of fusing multi-source prior information is developed to obtain the Weibull parameters' prior distributions and reduce the subjective bias of usual expert-judgment methods. The grid approximation method is applied to two-parameter Weibull distribution to derive the formulas for the parameters' posterior distributions and solve the calculation difficulty of high-dimensional integration. The method is then applied to the real data of a type of NC machine tool to implement a reliability assessment and obtain the mean time between failures(MTBF). The relative error of the proposed method is 5.8020×10-4 compared with the MTBF obtained by the MCMC algorithm. This result indicates that the proposed method is as accurate as MCMC. The newly developed solution for reliability modeling and assessment of NC machine tools under small-sample data is easy, practical, and highly suitable for widespread application in the engineering field; in addition, the solution does not reduce accuracy.

  9. Abnormalities in itch sensation and skin barrier function in atopic NC/Tnd mice.

    PubMed

    Amagai, Yosuke; Matsuda, Hiroshi; Tanaka, Akane

    2013-01-01

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dryness and itchy skin. Genetic factors as well as other factors, including abnormality in skin barrier function, hypersensitivity of itch sensory nerves, and dysfunction of the immune system, strongly affect the onset and exacerbation of AD. Recently, it has become clear that itch sensation is closely related to pain sensation. By using NC/Tnd mice, a unique spontaneous animal model for human AD, we found abnormalities in sensitivity against external stimuli as compared to two standard strains, BALB/c and B6 mice. Particularly, in conventional NC/Tnd mice with AD, stimulation against transient receptor potential (TRP) V1 reduced the scratching behavior, suggesting the possibility of a TRPV1 modulator in the treatment of atopic itch. The review outlines observations regarding itch sensation and skin barrier function in NC/Tnd mice by using a novel itch quantification system for the laboratory animals, which may bring great progress in the future study of itch.

  10. How do ncRNAs guide chromatin-modifying complexes to specific locations within the nucleus?

    PubMed

    Scott, Maxwell J; Li, Fang

    2008-01-01

    Transcriptome analyses have led to the realization that eukaryotic cells make a large number of noncoding RNAs (ncRNAs). It appears that some of these are involved in guiding chromatin-modifying complexes to specific locations within the nucleus. How such ncRNAs function is largely unknown but various models have been proposed. Here we briefly discuss the evidence supporting two such models; that ncRNAs function by annealing either with nascent transcripts or with homologous DNA sequences. We then review a third model that is based on our recent work on the role of the noncoding roX RNAs in the localization of the MSL complex to sites on the X chromosome in Drosophila. Our results suggest that the MSL1 and MSL2 proteins bind to chromatin but it is the incorporation of the roX RNAs into the complex that somehow alters the binding specificity of the MSL1/MSL2 proteins to recognize sites on the X chromosome.

  11. 38 CFR 48.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 48.645 Section 48.645 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Federal agency or agency. Federal agency or agency means any United States executive department, military department, government corporation, government controlled corporation, any other establishment in...

  12. Federal Law on Consumer Deception: An Agency by Agency Analysis.

    ERIC Educational Resources Information Center

    Zweibel, George J.

    A comprehensive analysis of statutes and regulations on consumer deception administered by thirty government agencies is provided in this report. Each agency's chapter includes a brief description of the agency, and a detailed listing of all deceptive trade practices prohibited by that agency's enabling legislation, regulations, or other sources…

  13. 10 CFR 607.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Federal agency or agency. 607.645 Section 607.645 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.645 Federal agency or agency. Department of Energy means the...

  14. COBRA-NC: a thermal hydraulics code for transient analysis of nuclear reactor components. Volume 2. COBRA-NC numerical solution methods

    SciTech Connect

    Thurgood, M.J.; George, T.L.; Wheeler, C.L.

    1986-04-01

    The COBRA-NC computer program has been developed to predict the thermal-hydraulic response of nuclear reactor components to thermal-hydraulic transients. The code solves the multicomponent, compressible three-dimensional, two-fluid, three-field equations for two-phase flow. The three fields are the vapor field, the continuous liquid field, and the liquid drop field. The code has been used to model flow and heat transfer within the reactor core, the reactor vessel, the steam generators, and in the nuclear containment. This volume describes the finite-volume equations and the numerical solution methods used to solve these equations. It is directed toward the user who is interested in gaining a more complete understanding of the numerical methods used to obtain a solution to the hydrodynamic equations.

  15. 76 FR 30392 - Pisgah Yarn and Dyeing Company Including On-Site Leased Workers From Manpower, Inc. Old Fort, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ...] Pisgah Yarn and Dyeing Company Including On-Site Leased Workers From Manpower, Inc. Old Fort, NC; Notice... Yarn & Dyeing Company, Old Fort, North Carolina (subject firm). The worker group includes...

  16. Poplar breeding and testing strategies in the NC US: Demonstration of potential yield and consideration of future research needs.

    SciTech Connect

    Riemenschneider, Don; Berguson, William E; Dickmann, Don; Hall, Richard

    2004-06-30

    The objective of this project was to extend previous poplar breeding and selection in the NC US by implementing a regional testing system with multiple test locations in Minnesota, Iowa, Wisconsin and Michigan.

  17. INDOOR/OUTDOOR PARTICLE SIZE DISTRIBUTIONS MEASURED IN SELECT HOMES IN THE RALEIGH-DURHAM-CHAPEL HILL, NC AREA

    EPA Science Inventory

    Particle size distributions were measured indoors and outdoors of six residences in the Raleigh-Durham-Chapel Hill, NC area to characterize the factors affecting particle concentrations in the indoor environment, including infiltration of outdoor aerosols. Size resolved partic...

  18. 76 FR 61076 - Foreign-Trade Zone 57-Mecklenburg County, NC; Termination of Review of Application for Subzone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... Application for Subzone; FMS Enterprises USA, Inc. (Para- Aramid UD Shield); Lincolnton, NC Notice is hereby... UD shield at the manufacturing facility of FMS Enterprises USA, Inc., located in Lincolnton,...

  19. Study of mouse spleen "natural cytotoxic" (NC) cell activity related to in vivo administration of B4 coxsackievirus.

    PubMed

    Voiculescu, C; Roşu, L; Rogoz, S

    1987-01-01

    By using A2G 40-day-old mice as responders, the influence of in vivo infection with a human strain of B4 coxsackievirus on "natural cytotoxic" (NC) cell activity was assayed, in relation to other immunomodulating treatments (beta-interferon, interleukin-1, or prostaglandin-E2). A significant increase of NC cell cytolysis was noticed in virus-infected mouse group, as compared to the control. The NC cell stimulation exerted by in vivo administration of beta-interferon or of interleukin-1 was not modified in virus-infected groups, but coxsackievirus was able to prevent the inhibitory effects of prostaglandin-E2 at the NC cell activity level when the cytotoxic assays were performed with 20:1 and 10:1 effector/"target" cell ratios, respectively. A possible extrapolation of results in the human medical practice is discussed.

  20. Metacognition of Agency

    ERIC Educational Resources Information Center

    Metcalfe, Janet; Greene, Matthew Jason

    2007-01-01

    The feeling that we are agents, intentionally making things happen by our own actions, is foundational to our understanding of ourselves as humans. People's metacognitions of agency were investigated in 4 experiments. Participants played a game in which they tried to touch downward scrolling Xs and avoid touching Os. Variables that affected…

  1. Youth Media and Agency

    ERIC Educational Resources Information Center

    Hauge, Chelsey

    2014-01-01

    This article addresses how capacity is conceived of and understood in youth media/civic education programming, and how beliefs about agency, development, relationality and youth manifests in the discourses, programmes, and practices of organizations operating youth media programmes. Through attention to a youth media and development programme in…

  2. Cooperation Among State Agencies

    ERIC Educational Resources Information Center

    Wattenbarger, James L.; Hansen, Dean M.

    1975-01-01

    Most states have separate agencies to deal with vocational education, adult education, and community colleges. Because current procedures for interagency cooperation are inadequate and often nonproductive, there is a need for a national or extra-state catalyst to encourage cooperation in a positive way. Five strategies for cooperation are…

  3. Enhanced transport of 2,2',5,5'-polychlorinated biphenyl by natural organic matter (NOM) and surfactant-modified fullerene nanoparticles (nC60).

    PubMed

    Wang, Lilin; Huang, Yi; Kan, Amy T; Tomson, Mason B; Chen, Wei

    2012-05-15

    Stable colloidal suspensions of buckminsterfullerene (nC(60)) in aqueous environments can significantly affect the fate and transport of hydrophobic organic contaminants by serving as a contaminant carrier. In this study, we examined enhanced transport of 2,2',5,5'-polychlorinated biphenyl (PCB) in saturated sandy soil columns by a variety of nC(60) samples, including an nC(60) sample prepared by the typical solvent exchange method, as well as eight natural organic matter (NOM) or surfactant-modified nC(60) samples, prepared by phase-transferring C(60) from toluene to an NOM or a surfactant solution. Whereas the NOM- and surfactant-modified nC(60) samples have mobility similar to the unmodified nC(60), their contaminant-mobilizing capabilities are significantly greater: breakthrough of PCB increases by 47.2 to 227% with the surfactant-modified nC(60) samples and by 233 to 370% with the NOM-modified nC(60) samples. The significantly enhanced contaminant-mobilizing capability of the modified nC(60) is likely due to a combined effect of increased adsorption affinities and increased tendency of desorption nonequilibrium, likely caused by the changes of nC(60) aggregation properties induced by the presence of NOM or surfactant. Findings in this study indicate that nC(60) formed in different processes might have vastly different effects on contaminant fate and transport.

  4. Normativity, agency, and life.

    PubMed

    Barham, James

    2012-03-01

    There is an immense philosophical literature dealing with the notions of normativity and agency, as well as a sizeable and rapidly growing scientific literature on the topic of autonomous agents. However, there has been very little cross-fertilization between these two literatures. As a result, the philosophical literature tends to assume a somewhat outdated mechanistic image of living things, resulting in a quasi-dualistic picture in which only human beings, or the higher animals, can be normative agents properly speaking. From this perspective, the project of 'naturalizing normativity' becomes almost a contradiction in terms. At the same time, the scientific literature tends to misuse 'normativity,' 'agency,' and related terms, assuming that it is meaningful to ascribe these concepts to 'autonomous agents' conceived of as physical systems whose behavior is to be explained in terms of ordinary physical law. From this perspective, the true depth of the difficulty involved in understanding what makes living systems distinctive qua physical systems becomes occluded. In this essay, I begin the attempt to remedy this situation. After some preliminary discussion of terminology and situating of my project within the contemporary philosophical landscape, I make a distinction between two different aspects of the project of naturalizing normativity: (1) the 'Scope Problem,' which consists in saying how widely in nature our concept of normative agency may properly be applied; and (2) the 'Ground Problem,' which consists in rationalizing the phenomenon of normative agency in terms of the rest of our knowledge of nature. Then, in the remainder of this paper, I argue that the Scope Problem ought to be resolved in favor of attributing normative agency, in the proper sense of those words, to living things as such. The Ground Problem will be discussed in a companion paper at a later time.

  5. Investigation of Gd3N@C2n(40≤n≤44) family by Raman and inelastic electron tunneling spectroscopy

    NASA Astrophysics Data System (ADS)

    Burke, Brian G.; Chan, Jack; Williams, Keith A.; Ge, Jiechao; Shu, Chunying; Fu, Wujun; Dorn, Harry C.; Kushmerick, James G.; Puretzky, Alexander A.; Geohegan, David B.

    2010-03-01

    The structure and vibrational spectrum of Gd3N@C80 is studied through Raman and inelastic electron tunneling spectroscopy as well as density-functional theory and universal force field calculations. Hindered rotations, shown by both theory and experiment, indicate the formation of a Gd3N-C80 bond which reduces the ideal icosahedral symmetry of the C80 cage. The vibrational modes involving the movement of the encapsulated species are a fingerprint of the interaction between the fullerene cage and the core complex. We present Raman data for the Gd3N@C2n(40≤n≤44) family as well as Y3N@C80 , Lu3N@C80 , and Y3N@C88 for comparison. Conductance measurements have been performed on Gd3N@C80 and reveal a Kondo effect similar to that observed in C60 .

  6. Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli.

    PubMed

    Riu, In-Hyun; Shin, Il-Soo; Do, Su-Il

    2008-07-18

    cDNAs encoding three isoforms of OGT (ncOGT, mOGT, and sOGT) were expressed in Escherichia coli in which the coexpression system of OGT with target substrates was established in vivo. No endogenous bacterial proteins were significantly O-GlcNAcylated by any type of OGT isoform while co-expressed p62 and Sp1 were strongly O-GlcNAcylated by ncOGT. These results suggest that most of bacterial proteins appear not to be recognized as right substrates by mammalian OGT whereas cytosolic environments may supply UDP-GlcNAc enough to proceed to O-GlcNAcylation in E. coli. Under these conditions, sOGT was auto-O-GlcNAcylated whereas ncOGT and mOGT were not. Importantly, we found that when Sp1 was coexpressed, ncOGT can O-GlcNAcylate not only Sp1 but also many bacterial proteins. Our findings suggest that Sp1 may modulate the capability of target recognition of ncOGT by which ncOGT can be led to newly recognize bacterial proteins as target substrates, finally generating the O-glyco-bacteria. Our results demonstrate that the O-glyco-bacteria showed enhanced thermal resistance to allow cell survival at a temperature as high as 52 degrees C.

  7. EFFECTS OF DIESEL EXHAUST ON PULMONARY RESPONSES DURING ALLERGIC SENSITIZATION TO AEROSOLIZED OVALBUMIN IN BALB/C MICE

    EPA Science Inventory

    Effects of Diesel Exhaust on Pulmonary Responses During Allergic Sensitization to Aerosolized Ovalbumin in BALB/c Mice. P. Singh1, M.J. Daniels1, D. Andrews1, E. Boykin1, W. P. Linak2 and M.I. Gilmour1. 1USEPA, ORD, NHEERL, RTP, NC. 2 USEPA, ORD, NRMRL, RTP, NC.

    Inhala...

  8. ENVIRONMENTAL POLLUTION AND THE IMMUNE SYSTEM: MECHANISMS OF IMMUNOTOXICITY ACROSS PHYLA

    EPA Science Inventory

    Environmental pollution and the immune system: Mechanisms of immunotoxicity across phyla. Bob Luebke and Dori Germolec, US EPA, RTP, NC and NIEHS, RTP, NC

    Our current understanding of immunotoxicology comes largely from studies done in rodents or using in vitro systems, a...

  9. DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE

    EPA Science Inventory

    DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE. TL Leavens1, MW Case1, RA Pegram1, BC Blount2, DM DeMarini1, MC Madden1, and JL Valentine3. 1NHEERL, USEPA, RTP, NC, USA; 2CDC, Atlanta, GA, USA; 3RTI, RTP, NC, USA.
    The disinfection byproduct ...

  10. Cellular Stress Response to Engineered Nanoparticles: Effect of Size, Surface Coating, and Cellular Uptake

    EPA Science Inventory

    CELLULAR STRESS RESPONSE TO ENGINEERED NANOPARTICLES: EFFECT OF SIZE, SURFACE COATING, AND CELLULAR UPTAKE RY Prasad 1, JK McGee2, MG Killius1 D Ackerman2, CF Blackman2 DM DeMarini2 , SO Simmons2 1 Student Services Contractor, US EPA, RTP, NC 2 US EPA, RTP, NC The num...

  11. Effects of Organophosphorus Flame Retardants on Spontaneous Activity in Neuronal Networks Grown on Microelectrode Arrays

    EPA Science Inventory

    EFFECTS OF ORGANOPHOSPHORUS FLAME RETARDANTS ON SPONTANEOUS ACTIVITY IN NEURONAL NETWORKS GROWN ON MICROELECTRODE ARRAYS TJ Shafer1, K Wallace1, WR Mundy1, M Behl2,. 1Integrated Systems Toxicology Division, NHEERL, USEPA, RTP, NC, USA, 2National Toxicology Program, NIEHS, RTP, NC...

  12. Assessment of phthalate-induced changes in fetal rat testis gene expression using an rt-PCR array

    EPA Science Inventory

    Lambright, CS’, Sampson, H2, Furr, i1, Evans, N’, Hannas, B’, Gray, LE, Jr.’, VS Wilson1. 1USEPA, NHEERL, RTP, NC, 2USEPA, NHEERL, RTP, NC, ORISE Fellow. Phthalate esters (PE) such as diethyl hexyl phthalate (DEHP) produce reproductive malformations in male rodents by reduction o...

  13. Agency, time, and causality

    PubMed Central

    Widlok, Thomas

    2014-01-01

    Cognitive Scientists interested in causal cognition increasingly search for evidence from non-Western Educational Industrial Rich Democratic people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition. PMID:25414683

  14. Agency, time, and causality.

    PubMed

    Widlok, Thomas

    2014-01-01

    Cognitive Scientists interested in causal cognition increasingly search for evidence from non-Western Educational Industrial Rich Democratic people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition.

  15. Dimerized Translationally Controlled Tumor Protein-Binding Peptide Ameliorates Atopic Dermatitis in NC/Nga Mice

    PubMed Central

    Jin, Xing-Hai; Lim, Juhyeon; Shin, Dong Hae; Maeng, Jeehye; Lee, Kyunglim

    2017-01-01

    Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group. Treatment with dTBP2 also decreased the serum levels of IgE and reduced IL-17A content in skin lesions and inhibited the expression of mRNAs of interleukin IL-4, IL-5, IL-6, IL-13, macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and thymic stromal lymphopoietin (TSLP). These findings indicate that dTBP2 not only inhibits the release of Th2 cytokine but also suppresses the production of proinflammatory cytokines in AD-like skin lesions in NC/Nga mice, by inhibiting TCTP dimer, in allergic responses. Therefore, dTCTP is a therapeutic target for AD and dTBP2 appears to have a potential role in the treatment of AD. PMID:28134765

  16. NATO Agency Reform

    DTIC Science & Technology

    2011-04-30

    and tested to determine its value. We take seriously the pernicious effects of the so-called “ theory – practice” gap, which would separate the...organized around a specific product or service, there are several that fill purely functional roles , such as the Research and Technology Agency...point, strategy development theory had focused on the forces of technology, size of an organization, and structural variation. In reviewing the

  17. Photoabsorption spectrum of the Sc3N@C80 molecule

    NASA Astrophysics Data System (ADS)

    Chen, Zhifan; Msezane, Alfred Z.

    2012-12-01

    The photoabsorption spectrum of the Sc3N@C80 molecule has been studied in the photon energy range of 30 to 50 eV using the time-dependent density functional theory. The results demonstrate that the confinement effect is related to the location of the encaged element inside the C80 molecule. We conclude that the confinement effect will be strongest if the element is at the centre of the fullerene cage, and that when the element is located at the off-centre position, the peak of the photoabsorption spectrum may be averaged out or even suppressed.

  18. 2 CFR 902.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY Reserved REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 902.645 Federal agency or agency. Department of Energy means the U.S. Department of Energy (DOE), including the...

  19. 2 CFR 902.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ENERGY Reserved REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 902.645 Federal agency or agency. Department of Energy means the U.S. Department of Energy (DOE), including the...

  20. Measurement of one and two bond N-C couplings in large proteins by TROSY-based J-modulation experiments.

    PubMed

    Liu, Yizhou; Prestegard, James H

    2009-09-01

    Residual dipolar couplings (RDCs) between NC' and NC(alpha) atoms in polypeptide backbones of proteins contain information on the orientation of bond vectors that is complementary to that contained in NH RDCs. The (1)J(NC)(alpha) and (2)J(NC)(alpha) scalar couplings between these atoms also display a Karplus relation with the backbone torsion angles and report on secondary structure. However, these N-C couplings tend to be small and they are frequently unresolvable in frequency domain spectra having the broad lines characteristic of large proteins. Here a TROSY-based J-modulated approach for the measurement of small (15)N-(13)C couplings in large proteins is described. The cross-correlation interference effects inherent in TROSY methods improve resolution and signal to noise ratios for large proteins, and the use of J-modulation to encode couplings eliminates the need to remove frequency distortions from overlapping peaks during data analysis. The utility of the method is demonstrated by measurement of (1)J(NC'), (1)J(NC)(alpha) , and (2)J(NC)(alpha) scalar couplings and (1)D(NC') and D(NC)(alpha) residual dipolar couplings for the myristoylated yeast ARF1.GTPgammas protein bound to small lipid bicelles, a system with an effective molecule weight of approximately 70kDa.

  1. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  2. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  3. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  4. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  5. 31 CFR 20.645 - Federal agency or agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Federal agency or agency. 20.645 Section 20.645 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.645 Federal agency or...

  6. DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.

    PubMed

    Salhi, Adil; Essack, Magbubah; Alam, Tanvir; Bajic, Vladan P; Ma, Lina; Radovanovic, Aleksandar; Marchand, Benoit; Schmeier, Sebastian; Zhang, Zhang; Bajic, Vladimir B

    2017-04-07

    Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA ( www.cbrc.kaust.edu.sa/des_ncrna ). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer's disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.

  7. Topical Application of Eupatilin Ameliorates Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

    PubMed Central

    Lee, Ji Hyun; Lee, Ye Jin; Lee, Jun Young

    2017-01-01

    Background Atopic dermatitis (AD) is an inflammatory skin disorder with severe pruritus. Despite advancements in medicine, therapeutic treatments for AD are still limited. Eupatilin (5,7-dihydroxy-30,40,6-trimethoxyflavone) is one of the lipophilic flavonoids from Artemisia umbelliformis Lam. and Artemisia genipi Weber. Objective Although it has been reported to act a role in improving inflammation, its action on AD is uncertain. In this study, we examined the role of eupatilin on AD-like skin lesions in NC/Nga mice. Methods 2,4-dinitrochlorobenzene was repeatedly applied to the ear of NC/Nga mice to produce AD-like skin lesions. Eupatilin (1%, once a day for 5 consecutive days/week) was applied topically for four weeks for the evaluation of its therapeutic effects. Results 1% eupatilin cream significantly reduced the clinical severity score of AD-like lesions, compared to the vehicle (p<0.005). A histopathological analysis revealed that 1% eupatilin cream significantly decreased the mast cell infiltration as well as inflammatory cell infiltration, compared to the vehicle (p<0.005). We showed that 1% eupatilin cream significantly reduced the expression of thymic stromal lymphopoietin, tumor necrosis factor-α, interleukin-4, and interleukin-19, but not interferon-γ, compared to the vehicle (p<0.005). Conclusion Considering the therapeutic reaction of eupatilin on AD-like lesions as in this study, the substance has a promising to be an adjuvant topical agent for the control of AD. PMID:28223748

  8. Morphological, compositional, structural, and optical properties of Si-nc embedded in SiOx films

    PubMed Central

    2012-01-01

    Structural, compositional, morphological, and optical properties of silicon nanocrystal (Si-nc) embedded in a matrix of non-stoichiometric silicon oxide (SiOx) films were studied. SiOx films were prepared by hot filament chemical vapor deposition technique in the 900 to 1,400°C range. Different microscopic and spectroscopic characterization techniques were used. The film composition changes with the growth temperature as Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy reveal. High-resolution transmission electron microscopy supports the existence of Si-ncs with a diameter from 1 to 6.5 nm in the matrix of SiOx films. The films emit in a wide photoluminescent spectrum, and the maximum peak emission shows a blueshift as the growth temperature decreases. On the other hand, transmittance spectra showed a wavelength shift of the absorption border, indicating an increase in the energy optical bandgap, when the growth temperature decreases. A relationship between composition, Si-nc size, energy bandgap, PL, and surface morphology was obtained. According to these results, we have analyzed the dependence of PL on the composition, structure, and morphology of the Si-ncs embedded in a matrix of non-stoichiometric SiOx films. PMID:23110990

  9. Influence of substrate bias voltage on the microstructure of nc-SiOx:H film

    NASA Astrophysics Data System (ADS)

    Li, Hui-Min; Yu, Wei; Xu, Yan-Mei; Ji, Yun; Jiang, Zhao-Yi; Wang, Xin-Zhan; Li, Xiao-Wei; Fu, Guang-Sheng

    2015-02-01

    Amorphous silicon oxide containing nanocrystalline silicon grain (nc-SiOx:H) films are prepared by a plasma-enhanced chemical vapor deposition technique at different negative substrate bias voltages. The influence of the bias voltage applied to the substrate on the microstructure is investigated. The analysis of x-ray diffraction spectra evidences the in situ growth of nanocrystalline Si. The grain size can be well controlled by varying the substrate bias voltage, and the largest size is obtained at 60 V. Fourier transform infrared spectra studies on the microstructure evolutions of the nc-SiOx:H films suggest that the absorption peak intensities, which are related to the defect densities, can be well controlled. It can be attributed to the fact that the negative bias voltage provides a useful way to change the energies of the particles in the deposition process, which can provide sufficient driving force for the diffusion and movement for the species on the growing surface and effectively passivate the dangling bonds. Also the larger grain size and lower band gap, which will result in better photosensitivity, can also be obtained with a moderate substrate bias voltage of 60 V. Project supported by the Key Basic Research Project of Hebei Province, China (Grant No. 12963930D), the Natural Science Foundation of Hebei Province, China (Grant No. F2013201250), and the Science and Technology Research Projects of the Educational Department of Hebei Province, China (Grant No. ZH2012030).

  10. The interstellar (C-12)N/(C-13)N ratio toward Zeta Persei

    NASA Technical Reports Server (NTRS)

    Kaiser, Mary E.; Wright, Edward L.; Hawkins, Isabel

    1991-01-01

    High-resolution, high signal-to-noise observations of interstellar CN toward Zeta Per are performed to determine the C-12/C-13 isotope ratio in this line of sight. Observations of (C-12)N/(C-13)N in several diffuse clouds are performed to assess whether CN suffers from isotope-selective effects. Values are obtained which are higher than the value toward Zeta Oph determined by Crane and Hegyi (1988) and lower than the results toward the more reddened stars HD 21483 obtained by Meyer et al. (1989) and Palazzi et al. (1990). Theory and observations indicate the existence of a spatial C-12/C-13 gradient which decreases toward the Galactic center at an approximate rate of 12 percent/kpc at the distance of the solar radius. It is argued that since a gradient of this character cannot explain the CN results, isotope-selective effects provide a more likely explanation for the large range in (C-12)N/(C-13)N ratios.

  11. Andrew Wyeth and N.C. Wyeth: a psychodynamic perspective on father and son.

    PubMed

    Shaw, Jon A

    2013-01-01

    This paper examines the relationship between two extraordinary artists, father and son--N.C. Wyeth (1882-1945) and Andrew Wyeth (1917-2009)--and their art. N.C. Wyeth, the father, the most famous illustrator of his day, painted scenes full of drama and action, often of men engaged in violent life and death struggles. N.C. was unable to separate from his powerful mother and yearned for his iconic father. He thought himself an artistic failure and dedicated himself to raising his children to be geniuses. The youngest son, Andrew Wyeth, who lived a "secret life," painted scenes often characterized by pathos: bleak and barren landscapes, leaden skies, tire tracks, gray framed houses, desiccated fields, and circling buzzards. In the father-son relationship, we often seen three themes perpetuated developmentally: (1) the son's identification with the innermost conflicts of his father; (2) the yearning for the iconic father of his youth; and (3) a continuation and disavowal of his father's life. These themes are played out in the relationship between Andrew Wyeth and his father.

  12. Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice.

    PubMed

    Kim, So Young; Sohn, Eun Jeong; Kim, Dae Won; Jeong, Hoon Jae; Kim, Mi Jin; Kang, Hye Won; Shin, Min Jea; Ahn, Eun Hee; Kwon, Soon Won; Kim, Young Nam; Kwon, Hyung Joo; Kim, Tae-Yoon; Lee, Kil Soo; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2011-07-01

    Immunophilin, FK506-binding protein 12 (FK506BP), is a receptor protein for the immunosuppressive drug FK506 by the FK506BP/FK506 complex. However, the precise function of FK506BP in inflammatory diseases remains unclear. Therefore, we examined the protective effects of FK506BP on atopic dermatitis (AD) in tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ)-induced HaCaT cells and 2,4-dinitrofluorobenzene-induced AD-like dermatitis in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice using a cell-permeable PEP-1-FK506BP. Transduced PEP-1-FK506BP significantly inhibited the expression of cytokines, as well as the activation of NF-κB and mitogen-activated protein kinase (MAPK) in TNF-α/IFN-γ-induced HaCaT cells. Furthermore, topical application of PEP-1-FK506BP to NC/Nga mice markedly inhibited AD-like dermatitis as determined by a histological examination and assessment of serum IgE levels, as well as cytokines and chemokines. These results indicate that PEP-1-FK506BP inhibits NF-κB and MAPK activation in cells and AD-like skin lesions by reducing the expression levels of cytokines and chemokines, thus suggesting that PEP-1-FK506BP may be a potential therapeutic agent for AD.

  13. Developing Moral Agency through Narrative

    ERIC Educational Resources Information Center

    Pasupathi, Monisha; Wainryb, Cecilia

    2010-01-01

    This paper poses the following question: When, in spite of knowing that it is wrong, people go on to hurt others, what does this mean for the development of moral agency? We begin by defining moral agency and briefly sketching relations between moral agency and other concepts. We then outline what three extant literatures suggest about this…

  14. Spin-flavor structure of chiral-odd generalized parton distributions in the large-Nc limit

    DOE PAGES

    Schweitzer, P.; Weiss, C.

    2016-10-05

    We study the spin-flavor structure of the nucleon's chiral-odd generalized parton distributions (transversity GPDs) in the large-Nc limit of QCD. In contrast to the chiral-even case, only three combinations of the four chiral-odd GPDs are nonzero in the leading order of the 1/Nc expansion: E-barT = ET+2H-tildeT, HT, and E-tildeT. The degeneracy is explained by the absence of spin-orbit interactions correlating the transverse momentum transfer with the transverse quark spin. It can also be deduced from the natural Nc scaling of the quark-nucleon helicity amplitudes associated with the GPDs. In the GPD E-barT the flavor-singlet component u+d is leading inmore » the 1/Nc expansion, while in HT and E-tildeT it is the flavor-nonsinglet components u–d. Furthermore, the large-Nc relations are consistent with the spin-flavor structure extracted from hard exclusive π0 and η electroproduction data, if it is assumed that the processes are mediated by twist-3 amplitudes involving the chiral-odd GPDs and the chiral-odd pseudoscalar meson distribution amplitudes.« less

  15. Prediction of the Spectroscopic Parameters of New Iron Compounds: Hydride of Iron Cyanide/Isocyanide, HFeCN/HFeNC

    NASA Astrophysics Data System (ADS)

    Redondo, Pilar; Barrientos, Carmen; Largo, Antonio

    2016-09-01

    Iron is the most abundant transition metal in space. Its abundance is similar to that of magnesium, and until today only, FeO and FeCN have been detected. However, magnesium-bearing compounds such as MgCN, MgNC, and HMgNC are found in IRC+10216. It seems that the hydrides of iron cyanide/isocyanide could be good candidates to be present in space. In the present work we carried out a characterization of the different minima on the quintet and triplet [C, Fe, H, N] potential energy surfaces, employing several theoretical approaches. The most stable isomers are predicted to be hydride of iron cyanide HFeCN, and isocyanide HFeNC, in their 5Δ states. Both isomers are found to be quasi-isoenergetics. The HFeNC isomer is predicted to lie about 0.5 kcal/mol below HFeCN. The barrier for the interconversion process is estimated to be around 6.0 kcal/mol, making this process unfeasible under low temperature conditions, such as those in the interstellar medium. Therefore, both HFeCN and HFeNC could be candidates for their detection. We report geometrical parameters, vibrational frequencies, and rotational constants that could help with their experimental characterization.

  16. Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

    PubMed Central

    Butryn, Agata; Schuller, Jan M; Stoehr, Gabriele; Runge-Wollmann, Petra; Förster, Friedrich; Auble, David T; Hopfner, Karl-Peter

    2015-01-01

    Swi2/Snf2 ATPases remodel substrates such as nucleosomes and transcription complexes to control a wide range of DNA-associated processes, but detailed structural information on the ATP-dependent remodeling reactions is largely absent. The single subunit remodeler Mot1 (modifier of transcription 1) dissociates TATA box-binding protein (TBP):DNA complexes, offering a useful system to address the structural mechanisms of Swi2/Snf2 ATPases. Here, we report the crystal structure of the N-terminal domain of Mot1 in complex with TBP, DNA, and the transcription regulator negative cofactor 2 (NC2). Our data show that Mot1 reduces DNA:NC2 interactions and unbends DNA as compared to the TBP:DNA:NC2 state, suggesting that Mot1 primes TBP:NC2 displacement in an ATP-independent manner. Electron microscopy and cross-linking data suggest that the Swi2/Snf2 domain of Mot1 associates with the upstream DNA and the histone fold of NC2, thereby revealing parallels to some nucleosome remodelers. This study provides a structural framework for how a Swi2/Snf2 ATPase interacts with its substrate DNA:protein complex. DOI: http://dx.doi.org/10.7554/eLife.07432.001 PMID:26258880

  17. Effects of aqueous stable fullerene nanocrystal (nC60) on copper (trace necessary nutrient metal): Enhanced toxicity and accumulation of copper in Daphnia magna.

    PubMed

    Tao, Xianji; He, Yiliang; Fortner, John D; Chen, Yongsheng; Hughes, Joseph B

    2013-08-01

    Our focus herein is to evaluate the potential interaction between nC60 and copper, a trace necessary metal, in light of the impact on toxicity. The non-observable effects concentration (NOEC) of nC60 was confirmed as 100μgL(-1) before. When Daphnia magna was exposed to the mixture of copper solution and nC60 suspension (100μgL(-1)), LC50 of 48h was lower than that when they were exposed to copper solution alone. This result clearly showed the decrease in NOEC of copper at the presence of nC60. Cu(2+)-ATPase activity was enhanced at the presence of nC60, indicating that copper transport involved with the uptake, distribution and depuration in body was increased. We further conducted experiments on accumulation of copper in D. magna. The observed equilibrium copper concentration in D. magna in the mixture of 100μgL(-1) nC60 and 1μgL(-1) copper solution reached 131μg (kg wet weight)(-1), which was more than twice that in copper solution only: 60μg (kg wet weight)(-1). This result demonstrated that the accumulation of copper in D. magna was significantly enhanced at the presence of even low nC60 concentration. Experiments also showed that copper was quickly adsorbed onto nC60. The absorption of copper onto D. magna was statistically correlated to the absorption of nC60 onto D. magna; this might be caused by nC60 facilitating the transfer of copper into D. magna. The absorption and desorption of copper to nC60 (pH=5.0) reached equilibrium quickly, which may be involved with the co-bioaccumulation and decrease in NOEC of Cu(2+) and nC60.

  18. Identification and characterization of a heparin binding site within the NC1 domain of chicken collagen XIV.

    PubMed

    Giry-Lozinguez, C; Aubert-Foucher, E; Penin, F; Deléage, G; Dublet, B; van der Rest, M

    1998-06-01

    Collagen XIV is known to bind to the dermatan sulfate chain of decorin and to the heparan sulfate chain of perlecan. To study its possible interaction with glycosaminoglycans, the NC1 domain of chicken collagen XIV was overproduced in E. coli. Purified NC1*(6-119)* appears poorly organized (the asterisks indicate the presence of extension sequences), but V8-protease generated fragments containing the 84-108 basic sequence tend to fold into alpha-helix. These fragments interact specifically with heparin, which induces an alpha-helical fold with a maximum effect for equimolar heparin/peptide ratio. These data demonstrate the existence of a glycosaminoglycan binding site in NC1.

  19. Serodiagnosis of Neospora caninum infection in cattle using a recombinant tNcSRS2 protein-based ELISA.

    PubMed

    Liu, Jing; Yu, Jinshu; Wang, Ming; Liu, Qun; Zhang, Wei; Deng, Chong; Ding, Jun

    2007-02-28

    The truncated NcSRS2 gene (tNcSRS2) by removal of the N-terminal hydrophobic sequence was cloned into the pGEX-6p-1 plasmid and subsequently expressed as a glutathione-S-transferase (GST) fusion protein. The purified recombinant tNcSRS2 protein was specific to Neospora caninum and was used in an ELISA for the diagnosis of neosporosis. There was a good agreement between tNctSRS2-based ELISA and three commercially available diagnostic kits (IDEXX ELISA, HIPRA ELISA and VMRD IFAT). Three hundred dairy cattle serum samples from 9 regions were tested by our ELISA. The herd prevalence was 100% and the overall prevalence was 20.3%. There was a statistically significant difference in seroprevalence between regions (P<0.01) and an association between abortion history and N. caninum seropositivity. Our study showed that neosporosis in dairy cattle is widespread in China.

  20. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  1. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  2. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  3. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  4. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  5. 31 CFR 353.1 - Official agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  6. 31 CFR 315.1 - Official agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... half), OH, PA, WV (northern panhandle). Federal Reserve Bank of Richmond, P.O. Box 27622, Richmond, VA 23261 Richmond, Atlanta AL, DC, FL, LA (southern half), MD, MS (southern half), NC, SC, TN (eastern...

  7. Induction of Plantaricin Production in Lactobacillus plantarum NC8 after Coculture with Specific Gram-Positive Bacteria Is Mediated by an Autoinduction Mechanism

    PubMed Central

    Maldonado, Antonio; Jiménez-Díaz, Rufino; Ruiz-Barba, José Luis

    2004-01-01

    Plantaricin NC8 (PLNC8), a coculture-inducible two-peptide bacteriocin from Lactobacillus plantarum NC8, has recently been purified and genetically characterized. Analysis of an 8.1-kb NC8 DNA region downstream of the PLNC8 operon revealed the presence of at least four operons involved in bacteriocin production, showing high homology to the plantaricin cluster in L. plantarum C11. However, we found a three-component regulatory operon involving a quorum-sensing mechanism. Two of these components, the induction factor (PLNC8IF) and the histidine kinase, are novel, while the response regulator is identical to PlnD from C11. Homologous expression of plNC8IF in NC8 allowed constitutive bacteriocin production. Heterologous expression of this gene in Lactococcus lactis MG1363 produced supernatants which promoted bacteriocin production in NC8. Reverse transcription-PCR studies indicated that cocultivation of NC8 with inducing cells promoted transcription of the bacteriocin and regulatory operons in NC8. An identical result was obtained after addition of an external source of PLNC8IF. We propose that the presence of specific bacteria could act as an environmental signal that is able to switch on bacteriocin production in L. plantarum NC8 via a quorum-sensing mechanism mediated by PLNC8IF. PMID:14973042

  8. Induction of plantaricin production in Lactobacillus plantarum NC8 after coculture with specific gram-positive bacteria is mediated by an autoinduction mechanism.

    PubMed

    Maldonado, Antonio; Jiménez-Díaz, Rufino; Ruiz-Barba, José Luis

    2004-03-01

    Plantaricin NC8 (PLNC8), a coculture-inducible two-peptide bacteriocin from Lactobacillus plantarum NC8, has recently been purified and genetically characterized. Analysis of an 8.1-kb NC8 DNA region downstream of the PLNC8 operon revealed the presence of at least four operons involved in bacteriocin production, showing high homology to the plantaricin cluster in L. plantarum C11. However, we found a three-component regulatory operon involving a quorum-sensing mechanism. Two of these components, the induction factor (PLNC8IF) and the histidine kinase, are novel, while the response regulator is identical to PlnD from C11. Homologous expression of plNC8IF in NC8 allowed constitutive bacteriocin production. Heterologous expression of this gene in Lactococcus lactis MG1363 produced supernatants which promoted bacteriocin production in NC8. Reverse transcription-PCR studies indicated that cocultivation of NC8 with inducing cells promoted transcription of the bacteriocin and regulatory operons in NC8. An identical result was obtained after addition of an external source of PLNC8IF. We propose that the presence of specific bacteria could act as an environmental signal that is able to switch on bacteriocin production in L. plantarum NC8 via a quorum-sensing mechanism mediated by PLNC8IF.

  9. Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reports.

    PubMed

    Henry, Theodore B; Petersen, Elijah J; Compton, Robert N

    2011-08-01

    This review aims to clarify inconsistencies in previous reports regarding the potential for aqueous aggregates of fullerenes (nC60) to generate reactive oxygen species (ROS) and cause toxicity in fish. Methods for evaluation of ROS production and toxicity of aqueous nC60 have evolved over time and limitations in initial studies have led to unintentional erroneous reports of nC60 ROS generation and toxicity. Some of these reports continue to lead to misconceptions of the environmental effects of C60. Critical review of the evidence (2007-2011) indicates that aqueous nC60 have minimal potential to produce ROS and that oxidative stress in fish is not induced by environmentally relevant exposure to nC60. Future studies should acknowledge that current evidence indicates low toxicity of nC60 and refrain from citing articles that attribute toxicity in fish to nC60 based on methods shown to be compromised by experimental artifacts. Despite low toxicity of nC60 in fish, an emerging environmental issue is that nC60 can affect environmental fate, transport, and bioavailability of co-contaminants in aquatic environments in a similar manner to that observed for other anthropogenic particulates (e.g., microplastics).

  10. Silencing nc886, a Non-Coding RNA, Induces Apoptosis of Human Endometrial Cancer Cells-1A In Vitro

    PubMed Central

    Hu, Zhuoying; Zhang, Hongyu; Tang, Liangdan; Lou, Meng; Geng, Yanqing

    2017-01-01

    Background The role that nc886, a non-coding microRNA, plays in human endometrial cancer is unknown. The present study aimed to describe the functional role of nc886 in human endometrial cancer-1A (HEC-1A) cell line, which may provide another target for human endometrial cancer treatment. Material/Methods The expression levels of nv886 in normal human endometrial tissue and the early phase and late phase of human endometrial cancer tissues were determined and compared by fluorescence in situ hybridization (FISH). Small interference RNA (siRNA) was used to inhibit nc886, and cell proliferation was evaluated with the MTT test. mRNA levels of PKR, NF-κB, vascular endothelial growth factor (VEGF), and caspase-3 were determined against glyceraldehyde 3-phosphate dehydrogenase (GAPDH between the HEC-1A control group and the silenced group (nc886 silenced with siRNA) by real-time reverse transcription polymerase chain reaction (RT-PCR). The protein levels of PKR (total and phosphorylated form), NF-κB, VEGF, and caspase-3 were determined against GAPDH by Western blotting, and cell apoptosis was determined by flow cytometry. Results Our results indicated that a higher level of nc886 was expressed in the late phase of human endometrial cancer tissue, less than in the early phase but still higher than in normal human endometrial tissue. After nc886 was silenced, protein levels of p-PKR (phosphorylated PKR) and caspase-3 were increased, whereas NF-κB and VEGF were decreased. Conclusions The rate of apoptosis in the silenced group was increased and the rate of cell proliferation was slower in comparison to the control. PMID:28298621

  11. Silencing nc886, a Non-Coding RNA, Induces Apoptosis of Human Endometrial Cancer Cells-1A In Vitro.

    PubMed

    Hu, Zhuoying; Zhang, Hongyu; Tang, Liangdan; Lou, Meng; Geng, Yanqing

    2017-03-16

    BACKGROUND The role that nc886, a non-coding microRNA, plays in human endometrial cancer is unknown. The present study aimed to describe the functional role of nc886 in human endometrial cancer-1A (HEC-1A) cell line, which may provide another target for human endometrial cancer treatment. MATERIAL AND METHODS The expression levels of nv886 in normal human endometrial tissue and the early phase and late phase of human endometrial cancer tissues were determined and compared by fluorescence in situ hybridization (FISH). Small interference RNA (siRNA) was used to inhibit nc886, and cell proliferation was evaluated with the MTT test. mRNA levels of PKR, NF-κB, vascular endothelial growth factor (VEGF), and caspase-3 were determined against glyceraldehyde 3-phosphate dehydrogenase (GAPDH between the HEC-1A control group and the silenced group (nc886 silenced with siRNA) by real-time reverse transcription polymerase chain reaction (RT-PCR). The protein levels of PKR (total and phosphorylated form), NF-κB, VEGF, and caspase-3 were determined against GAPDH by Western blotting, and cell apoptosis was determined by flow cytometry. RESULTS Our results indicated that a higher level of nc886 was expressed in the late phase of human endometrial cancer tissue, less than in the early phase but still higher than in normal human endometrial tissue. After nc886 was silenced, protein levels of p-PKR (phosphorylated PKR) and caspase-3 were increased, whereas NF-κB and VEGF were decreased. CONCLUSIONS The rate of apoptosis in the silenced group was increased and the rate of cell proliferation was slower in comparison to the control.

  12. Purification and characterization of a sialidase from Clostridium chauvoei NC08596.

    PubMed

    Heuermann, D; Roggentin, P; Kleineidam, R G; Schauer, R

    1991-04-01

    The sialidase secreted by Clostridium chauvoei NC08596 was purified to apparent homogeneity by ion-exchange chromatography, gel filtration, hydrophobic interaction-chromatography, FPLC ion-exchange chromatography, and FPLC gel filtration. The enzyme was enriched about 10,200-fold, reaching a final specific activity of 24.4 U mg-1. It has a relatively high molecular mass of 300 kDa and consists of two subunits each of 150 kDa. The cations Mn2+, Mg2+, and Ca2+ and bovine serum albumin have a positive effect on the sialidase activity, while Hg2+, Cu2+, and Zn2+, chelating agents and salt decrease enzyme activity. The substrate specificity, kinetic data, and pH optimum of the enzyme are similar to those of other bacterial sialidases.

  13. Rebamipide suppresses mite-induced asthmatic responses in NC/Nga mice.

    PubMed

    Murakami, Ikuo; Zhang, Ran; Kubo, Masayuki; Nagaoka, Kenjiro; Eguchi, Eri; Ogino, Keiki

    2015-10-15

    Allergic asthma caused by continuous allergen exposure evokes allergen-specific Th2 responses and is characterized by chronic airway inflammation and hyperresponsiveness. A previous report showed that rebamipide improved asthmatic symptoms in an ovalbumin/trypsin mice model. However, it is still unclear how rebamipide exerts its effects in asthma. In this study, rebamipide improved the asthmatic responses induced by mite exposure in NC/Nga mice, revealing the mechanism of this therapeutic effect. Rebamipide suppressed the infiltration of eosinophils into the airways and lung as well as attenuating the production of reactive oxygen species in tissues. In addition to these anti-inflammatory effects, rebamipide inhibited the production of IL-33, a member of the IL-1 family that drives the subsequent production of Th2-associated cytokines. These observations identify the point where rebamipide exerts its suppressive action on asthma and suggest that rebamipide has therapeutic potential in preventing mite-induced asthma.

  14. Perceived discrimination among Latino immigrants in new destinations: The case of Durham, NC1

    PubMed Central

    Flippen, Chenoa A.; Parrado, Emilio A.

    2015-01-01

    This paper draws on original survey data to assess the prevalence of perceived discrimination among Latin American immigrants to Durham, NC, a “new immigrant destinations” in the Southeastern United States. Even though discrimination has a wide-ranging impact on social groups, from blocked opportunities, to adverse health outcomes, to highlighting and reifying inter-group boundaries, research among immigrant Latinos is rare, especially in new destinations. Our theoretical framework and empirical analysis expand social constructivist approaches that view ethnic discrimination as emerging from processes of competition and incorporation. We broaden prior discussions by investigating the specific social forces that give rise to perceived discrimination. In particular, we examine the extent to which perceptions of unequal treatment vary by gender, elaborating on the situational conditions than differentiate discrimination experiences for men and women. We also incorporate dimensions unique to the contemporary Latino immigrant experience, such as legal status, family migration dynamics, and transnationalism. PMID:26848208

  15. Coherent chemistry with THz pulses: Ultrafast field-driven isomerization of LiNC

    NASA Astrophysics Data System (ADS)

    Pellouchoud, L. A.; Reed, E. J.

    2015-05-01

    The ability to coherently rearrange structures at the atomic scale is among the grand challenges of physical science. Some of the primary obstacles are nonadiabatic increases in energy, such as intramolecular vibrational relaxation (IVR) and electronic excitations. Motivated by recent advances in strong terahertz (THz) pulse generation, we investigate the potential of THz to circumvent these obstacles. Employing TDDFT-Ehrenfest simulations, we discover that strong THz pulses can drive isomerization of the LiNC molecule over barriers greater than 0.2 eV with very low ionization rates and, in the best case, less than 3 meV of residual excess energy. This work points to new possibilities in predictively manipulating chemical bonds in molecules and materials.

  16. Theoretical and experimental investigation of grinding marks in sphere NC grinding process

    NASA Astrophysics Data System (ADS)

    Wang, Peng; Zhang, Hao; Hui, Changshun

    2014-08-01

    Sphere ultra-precision NC grinding process with diamond cup wheel is widely used as an indispensable working procedure for manufacturing spherical, most aspherical, and some freeform surfaces. This paper presents a mathematic model of sphere grinding with cup diamond wheel based on homogeneous transformation method to simulate grinding marks. Different kinds of grinding marks are obtained by changing the geometrical parameters including the shift in axis X and Y axis and inclination angle deviation. Form accuracy and dimensional errors caused by geometrical parameters are also analyzed, and hence a three-step method utilizing grinding marks is proposed to correct these errors. A series of experiments are conducted and the results show that the proposed method is very efficient and effective in actual spherical surface generating process.

  17. Application of photoelectric autocollimator in detecting position precision of NC motorized stage

    NASA Astrophysics Data System (ADS)

    Yan, Bixi; Tan, Qimeng; Lv, Naiguang

    2010-11-01

    A photoelectric autocollimator, which consists of an optical autocollimator and an area CCD and whose standard deviation is less than 0.5" calibrated by a dual-frequency laser interferometer HP5528A, is proposed in the paper. The positional precision of a NC motorized stage is detected automatically and quickly by applying the photoelectric autocollimator calibrated and an optical polyhedron to finish the error compensation of the stage. According to GB/T 17421.2-2000, when the polyhedron and the stage both revolve with the same axis, the positional error of the stage is measured by the photoelectric autocollimator and then sent back to the controlling system of the stage manually or automatically. Experimental results show that an angle can be measured by the photoelectric autocollimator and the calculated position accuracy agrees with that which is measured by a Triangle autocollimator 500-57 at the same time.

  18. Improving quality of science through better animal welfare: the NC3Rs strategy.

    PubMed

    Prescott, Mark J; Lidster, Katie

    2017-03-22

    Good animal welfare is linked to the quality of research data derived from laboratory animals, their validity as models of human disease, the number of animals required to reach statistical significance and the reproducibility of in vivo studies. Identifying new ways of understanding and improving animal welfare, and promoting these in the scientific community, is therefore a key part of the work of the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). Our strategy for animal welfare includes funding research to generate an evidence base to support refinements, office-led data sharing to challenge existing practices, events and networks to raise awareness of the evidence base, and the creation of online and other resources to support practical implementation of refinement opportunities.

  19. Synthesis of nc-UO2 by controlled precipitation in aqueous phase

    NASA Astrophysics Data System (ADS)

    Jovani-Abril, R.; Gibilaro, M.; Janßen, A.; Eloirdi, R.; Somers, J.; Spino, J.; Malmbeck, R.

    2016-08-01

    Nanocrystalline UO2 has been produced through controlled precipitation from an electrolytically reduced U(IV) solution. The reduction process of U(VI) to U(IV) was investigated by cyclic voltammetry in combination with absorption spectrophotometry. Precipitation was achieved by controlled alkalinisation following closely the solubility line of U(IV) in aqueous media. The highest starting concentration used was 0.5 M uranylnitrate which yielded, with the equipment used, around 10 g material pro batch. The produced nc-UO2 was characterised by transmission electron microscopy (TEM) and x-ray diffraction (XRD) and exhibited the typical UO2+x fcc fluorite structure with an average crystallite size of 3.9 nm.

  20. Quantitative multichannel NC-AFM data analysis of graphene growth on SiC(0001)

    PubMed Central

    Held, Christian; Seyller, Thomas

    2012-01-01

    Summary Noncontact atomic force microscopy provides access to several complementary signals, such as topography, damping, and contact potential. The traditional presentation of such data sets in adjacent figures or in colour-coded pseudo-three-dimensional plots gives only a qualitative impression. We introduce two-dimensional histograms for the representation of multichannel NC-AFM data sets in a quantitative fashion. Presentation and analysis are exemplified for topography and contact-potential data for graphene grown epitaxially on 6H-SiC(0001), as recorded by Kelvin probe force microscopy in ultrahigh vacuum. Sample preparations by thermal decomposition in ultrahigh vacuum and in an argon atmosphere are compared and the respective growth mechanisms discussed. PMID:22428109

  1. Laboratory spectroscopy of MgNC - The first radioastronomical identification of Mg-bearing molecule

    NASA Astrophysics Data System (ADS)

    Kawaguchi, Kentarou; Kagi, Eriko; Hirano, Tsuneo; Takano, Shuro; Saito, Shuji

    1993-03-01

    The linear MgNC radical was detected, for the first time, by laboratory microwave spectroscopy, and six unidentified lines in IRC + 10216 reported by Guelin et al. (1986) were assigned to the transitions of this radical. The radical was produced in a free space absorption cell by a dc discharge in a mixture of magnesium vapor, argon, and cyanogen. Observed spectral lines in the 250-370 GHz region were analyzed by using the 2Sigma energy level expression, to give the rotational, centrifugal distortion and spin-rotation constants: B0 = 5966.8969(24) MHz, D0 = 0.004 2338(35) MHz, H0 = 0.308(16) x 10 exp -7 MHz, and gamma0 = 15.219(13) MHz, with one standard deviation in parentheses.

  2. Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice

    PubMed Central

    Park, Sang-Joon; Lee, Hyang-Ae; Kim, Jong Woo; Lee, Byoung-Seok; Kim, Eun-Joo

    2012-01-01

    Objective: To investigate the therapeutic effect of crude extract from Platycodon grandiflorum (PG) roots on atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Materials and Methods: To develop atopic dermatitis-like lesions, 200 μl of 0.3% 1-chloro-2, 4-dinitro benzene (DNCB) in acetone/olive oil (3:1) was applied 3 times a week for 2 weeks on the shaved skin of their backs. PG extract was dissolved in saline and orally administrated at concentrations of 300 and 500 mg/kg every day for 2 weeks. The therapeutic effect of PG on AD-like skin lesions was assessed by measuring skin severity scores and epithermal thickness, serum total immunoglobulin (Ig) E, histopathological findings for inflammatory cells including mast cells, macrophage and T cells, and mRNA expression of various cytokines related to the inflammatory and allergic response. The significance of inter-group differences was analyzed using the ANOVA test. Data were considered to be significant when P < 0.05 or P < 0.01. Results: Oral treatment of PG suppressed AD-like skin lesions according to the assessment of skin severity and epithermal thickness in the DNCB-treated NC/Nga mice. This alleviation was further correlated with a reduction of elevated serum total IgE or cytokine mRNA in the PG-treated group compared with vehicle-treated positive group. In addition, infiltrated inflammatory cells decreased on the skin lesions compared with vehicle-treated group. Conclusion: These results suggest that PG may have a potential therapeutic effect for AD via the inhibition of both inflammatory and allergic reaction. PMID:23087507

  3. Light-front representation of chiral dynamics with Δ isobar and large-Nc relations

    DOE PAGES

    Granados, C.; Weiss, C.

    2016-06-13

    Transverse densities describe the spatial distribution of electromagnetic current in the nucleon at fixed light-front time. At peripheral distances b = O(Mπ–1) the densities are governed by chiral dynamics and can be calculated model-independently using chiral effective field theory (EFT). Recent work has shown that the EFT results can be represented in first-quantized form, as overlap integrals of chiral light-front wave functions describing the transition of the nucleon to soft-pion-nucleon intermediate states, resulting in a quantum-mechanical picture of the peripheral transverse densities. We now extend this representation to include intermediate states with Δ isobars and implement relations based on themore » large-Nc limit of QCD. We derive the wave function overlap formulas for the Δ contributions to the peripheral transverse densities by way of a three-dimensional reduction of relativistic chiral EFT expressions. Our procedure effectively maintains rotational invariance and avoids the ambiguities with higher-spin particles in the light-front time-ordered approach. We study the interplay of πN and πΔ intermediate states in the quantum-mechanical picture of the densities in a transversely polarized nucleon. We show that the correct Nc-scaling of the charge and magnetization densities emerges as the result of the particular combination of currents generated by intermediate states with degenerate N and Δ. The off-shell behavior of the chiral EFT is summarized in contact terms and can be studied easily. As a result, the methods developed here can be applied to other peripheral densities and to moments of the nucleon's generalized parton distributions.« less

  4. Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model.

    PubMed

    Yamamoto, Yoshiyuki; Hyodo, Ichinosuke; Takigahira, Misato; Koga, Yoshikatsu; Yasunaga, Masahiro; Harada, Mitsunori; Hayashi, Tatsuyuki; Kato, Yasuki; Matsumura, Yasuhiro

    2014-07-01

    Anticancer agent-incorporating polymeric micelles accumulate effectively in tumors via the enhanced permeability and retention effect to exert potent antitumor effects. However, combined use of such micelles has not been elucidated. We compared the effect of combining the epirubicin-incorporating micelle NC-6300 and 1,2-diaminocyclohexane platinum (II) (oxaliplatin parent complex)-incorporating micelle NC-4016 (NCs) with that of epirubicin and oxaliplatin (E/O) in 44As3Luc cells using the combination index method. The in vivo antitumor activities of NCs and E/O were evaluated in mice bearing 44As3Luc xenografts. Pharmacokinetic analysis was performed by high-performance liquid chromatography and mass spectrometry. Cardiotoxicity of NC-6300 and epirubicin was assessed by echocardiography. Neurotoxicity of NC-4016 and oxaliplatin was evaluated by examining the paw withdrawal response to noxious mechanical stimuli. NCs showed a highly synergistic activity equivalent to E/O. In vivo, NCs exhibited higher antitumor activity in the subcutaneous tumor model and longer overall survival in the orthotopic tumor model than E/O (p < 0.001, p = 0.015, respectively). The intratumor concentrations of epirubicin and platinum were significantly higher following NCs than following E/O administration. Moreover, the micelles showed lower cardiotoxicity and neurotoxicity than the corresponding conventional drugs. The combined use of the micelles was associated with remarkable efficacy and favorable toxicities in the human gastric cancer model, and warrants the conduct of clinical trials.

  5. Ingersoll Rand in Davidson, N.C., to be Recognized Nationally by EPA for Climate Action

    EPA Pesticide Factsheets

    ATLANTA - Today, U.S. Environmental Protection Agency Administrator Gina McCarthy will recognize 17 organizations from around the country at the Climate Leadership Awards for their leadership and innovation in helping fight climate change. Ingersoll

  6. 34 CFR 84.645 - Federal agency or agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... means any United States executive department, military department, government corporation, government... 34 Education 1 2012-07-01 2012-07-01 false Federal agency or agency. 84.645 Section 84.645 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR...

  7. 24 CFR 21.645 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Federal agency or agency. 21.645 Section 21.645 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.645 Federal...

  8. 24 CFR 21.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Federal agency or agency. 21.645 Section 21.645 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.645 Federal...

  9. First-principles investigation of quantum transport through an endohedral N@C60 in the Coulomb blockade regime.

    PubMed

    Yu, Zhizhou; Chen, Jian; Zhang, Lei; Wang, Jian

    2013-12-11

    We report an investigation of Coulomb blockade transport through an endohedral N@C60 weakly coupled with aluminum leads, employing the first-principles method combined with the Keldysh non-equilibrium Green's function derived from the equation of motion beyond the Hartree-Fock approximation. The differential conductance characteristics of the molecular device are calculated within the Coulomb blockade regime, which shows the Coulomb diamond as observed experimentally. When the gate voltage is less than that of the degeneracy point, there are two peaks in the differential conductance with an excited state induced by the change of the exchange interaction between the spin of C60 and the encapsulated nitrogen atom due to the transition from N@C(1-)(60) to N@C(2-)(60), while for a gate voltage larger than that of the degeneracy point, no excited state is available due to the quenching of exchange energy. As a result, there is only one Coulomb blockade peak in the differential conductance from the electron tunneling through the highest energy level below the Fermi level. Our first-principles results are in good agreement with experimental data obtained by an endohedral N@C60 molecular device.

  10. Psych NP-NC: a benchmark graduate nurse practitioner program for meeting the mental health needs in North Carolina.

    PubMed

    Soltis-Jarrett, Victoria

    2011-01-01

    UNC-Chapel Hill's Psych NP-NC program prepares clinically and culturally proficient nurse practitioners to provide psychiatric and mental health care in North Carolina areas that are medically underserved and have a greater number of health disparities. This article reviews the program and the role of its graduates and makes policy recommendations for improving mental health care in the state.

  11. BARC 2009 Annual Report TO NC-1037: Genetic and functional genomic approaches to improve production and quality of pork

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The NC-1037 project addresses “Genetic and functional genomic approaches to improve production and quality of pork.” It has 2 objectives: 1) Further understand the dynamic genetic mechanisms that influence production efficiency and quality of pork; and 2) Discover genetic mechanisms controlling anim...

  12. Two-phase nc-TiN/a-(C,CNx) nanocomposite films: A HRTEM and MC simulation study

    NASA Astrophysics Data System (ADS)

    Guo, J.; Lu, Y. H.; Hu, X. J.; Shen, Y. G.

    2013-06-01

    The grain growth in two-phase nanocomposite Ti-Cx-Ny thin films grown by reactive close-field unbalanced magnetron sputtering in an Ar-N2 gas mixture with microstructures comprising of nanocrystalline (nc-) Ti(N,C) phase surrounded by amorphous (a-) (C,CNx) phase was investigated by a combination of high-resolution transmission electron microscopy (HRTEM) and Monte Carlo (MC) simulations. The HRTEM results revealed that amorphous-free solid solution Ti(C,N) thin films exhibited polycrystallites with different sizes, orientations and irregular shapes. The grain size varied in the range between several nanometers and several decade nanometers. Further increase of C content (up to ˜19 at.% C) made the amorphous phase wet nanocrystallites, which strongly hindered the growth of nanocrystallites. As a result, more regular Ti(C,N) nanocrystallites with an average size of ˜5 nm were found to be separated by ˜0.5-nm amorphous phases. When C content was further increased (up to ˜48 at.% in this study), thicker amorphous matrices were produced and followed by the formation of smaller sized grains with lognormal distribution. Our MC analysis indicated that with increasing amorphous volume fraction (i.e. increasing C content), the transformation from nc/nc grain boundary (GB)-curvature-driven growth to a/nc GB-curvature-driven growth is directly responsible for the observed grain growth from great inhomogeneity to homogeneity process.

  13. 76 FR 2713 - Croscill Acquisition, LLC, Currently Known as Croscill Home, LLC, Plant No. 8, Oxford, NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ..., Plant No. 8, Oxford, NC; Amended Certification Regarding Eligibility To Apply for Worker Adjustment... 25, 2009, applicable to workers of Croscill Acquisition, LLC, formerly doing business as Royal Home Fashions, a subsidiary of Croscill, Inc., Plant No. 8, Oxford, North Carolina. The notice was published...

  14. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  15. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  16. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  17. 33 CFR 334.450 - Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Cape Fear River and tributaries... AND RESTRICTED AREA REGULATIONS § 334.450 Cape Fear River and tributaries at Sunny Point Army Terminal, Brunswick County, NC; restricted area. (a) The area. That portion of Cape Fear River due west of the...

  18. CHANGES IN HEART RATE VARIABILITY AND LUNG FUNCTION OBSERVED IN NC PATROL TROOPERS EXPOSED TO PM AND AIR TOXICS

    EPA Science Inventory

    Changes in Heart Rate Variability and Lung Function in NC Patrol Troopers exposed to PM and Air Toxics

    Michael Riediker1, Wayne E Cascio1, Robert B Devlin2, Thomas Griggs1&4, Margaret Herbst1, Ronald W Williams3, Steve P McCorquodale4, Philip A Bromberg1
    1) University o...

  19. The Chlorella variabilis NC64A Genome Reveals Adaptation to Photosymbiosis, Coevolution with Viruses, and Cryptic Sex[C][W

    PubMed Central

    Blanc, Guillaume; Duncan, Garry; Agarkova, Irina; Borodovsky, Mark; Gurnon, James; Kuo, Alan; Lindquist, Erika; Lucas, Susan; Pangilinan, Jasmyn; Polle, Juergen; Salamov, Asaf; Terry, Astrid; Yamada, Takashi; Dunigan, David D.; Grigoriev, Igor V.; Claverie, Jean-Michel; Van Etten, James L.

    2010-01-01

    Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes. PMID:20852019

  20. MODELING TO EVOLVE UNDERSTANDING OF THE SHALLOW GROUND WATER FLOW SYSTEM BENEATH THE LIZZIE RESEARCH SITE, NC

    EPA Science Inventory

    The purpose of the modeling effort presented here is to evolve a conceptual model of ground-water flow at the Lizzie, NC research site using analytic solutions and field observations. The resulting analytic element parameterization of boundary conditions, aquifer transmissivitie...

  1. 76 FR 39155 - R.J. Corman Railroad Property, LLC-Acquisition Exemption-NC Railroad, Inc

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... Surface Transportation Board R.J. Corman Railroad Property, LLC--Acquisition Exemption--NC Railroad, Inc R... acquisition transaction is related to the notice of exemption in Docket No. FD 35364, R. J. Corman Railroad Company/Bardstown Line-- Lease and Operation Exemption--R. J. Corman Railroad Property, LLC, in which R....

  2. The Chlorella variabilis NC64A Genome Reveals Adaptation to Photosymbiosis, Coevolution with Viruses, and Cryptic Sex

    SciTech Connect

    Blanc, Guillaume; Duncan, Garry A.; Agarakova, Irina; Borodovsky, Mark; Gurnon, James; Kuo, Alan; Lindquist, Erika; Lucas, Susan; Pangailinan, Jasmyn; Polle, Juergen; Salamov, Asaf; Terry, Astrid; Yamada, Takashi; Dunigan, David D.; Grigoriev, Igor V.; Claverie, Jean-Michel; Etten, James L. Van

    2010-05-06

    Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes.

  3. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  4. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Albemarle Sound, Pamlico Sound... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  5. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  6. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Albemarle Sound, Pamlico Sound... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  7. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Albemarle Sound, Pamlico Sound... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  8. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Albemarle Sound, Pamlico Sound... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  9. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Albemarle Sound, Pamlico Sound... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  10. 33 CFR 334.420 - Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Pamlico Sound and adjacent waters... REGULATIONS § 334.420 Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations. (a) Bombing and rocket firing area in Pamlico Sound in vicinity of Brant Island—(1) The area. The...

  11. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  12. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  13. 33 CFR 334.410 - Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Albemarle Sound, Pamlico Sound... AND RESTRICTED AREA REGULATIONS § 334.410 Albemarle Sound, Pamlico Sound, and adjacent waters, NC; danger zones for naval aircraft operations. (a) Target areas—(1) North Landing River (Currituck...

  14. 33 CFR 334.420 - Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Pamlico Sound and adjacent waters... REGULATIONS § 334.420 Pamlico Sound and adjacent waters, N.C.; danger zones for Marine Corps operations. (a) Bombing and rocket firing area in Pamlico Sound in vicinity of Brant Island—(1) The area. The...

  15. 75 FR 7044 - T&S Hardwoods, Inc., Sylva, NC; Notice of Negative Determination Regarding Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration T&S Hardwoods, Inc., Sylva, NC; Notice of Negative Determination... facility to a foreign country. T&S Hardwoods, Inc. did not import hardwood lumber and did not...

  16. Emission Inventory: A local agency`s approach

    SciTech Connect

    Kestler, S.L.; Bien, D.L.; Gruber, L.R.

    1996-12-31

    The Department of Environmental Services-Air Quality Management (D.O.E.S.-A.Q.M.) in southwestern Ohio has inventoried stationary sources since the mid-1970`s. That inventory has changed over the years from one of unknown data quality to one of high quality and substantial use by the public, agency personnel and industry. Since 1990, the scope of the agency`s inventory has broadened to include the compilation of a local area source inventory every three years. This presentation explores a local agency`s {open_quotes}real life{close_quotes} approach to compiling their emission inventory. We will discuss the improvements made and the pitfalls encountered in the inventory process over the years.

  17. Effects of aqueous stable fullerene nanocrystals (nC60) on the food conversion from Daphnia magna to Danio rerio in a simplified freshwater food chain.

    PubMed

    Tao, Xianji; Li, Cuilan; Zhang, Bo; He, Yiliang

    2016-02-01

    Understanding the nanomaterial potential to the food conversion of two food chain levels is important in the ecosystem assessment as manufactured nanomaterials are being released into the environment. In this investigation, the food conversion from Daphnia magna (D. magna) (prey) to Danio rerio (D. rerio) (predator) was used as the study object of aqueous stable fullerene nanocrystals (nC60). Accumulated nC60 of D. magna was determined as the nominal initial exposure concentration for D. rerio. The results of 21-d dietary exposure experiment demonstrate that nC60 in D. magna decreased the body weight growths and condition factors of D. rerio, and reduced the food conversion ratio by 20% (from D. magna to D. rerio). Further, the experiments present that nC60 decrease three digestive enzymes activities of trypsinase, lipase, and amylase by 30, 29, and 55% in vivo, and by 60, 90, and 42% in vitro, respectively. Both in vivo and in vitro experiments indicated that nC60 was involved with the decrements of digestive enzymes activities. These decrements in digestive enzymes activities may be due to the deactivation caused by the adsorption of nC60 particles onto the surface or active center of digestive enzymes. Sum up, these results not only describe the nC60 deleterious effects on the food conversion from D. magna to D. rerio, but also provide some information regarding a probable food conversion inhibition mechanism of nC60.

  18. MYOCARDIAL AND CARDIOVASCULAR EFFECTS FOLLOWING PULMONARY EXPOSURE TO ZINC

    EPA Science Inventory

    CARDIOVASCULAR INJURY FOLLOWING PULMONARY EXPOSURE TO ZINC
    PS Gilmour, A Nyska, MC Schladweiler, AD Ledbetter, CF Moyer, JM Samet, and UP Kodavanti, CEMALB, UNC, Chapel Hill, NC; NIEHS, RTP, NC; US EPA/ORD/NHEERL/HSD, Chapel Hill, NC; Pathology Associates, Inc., Raleigh, NC; ...

  19. Complex interplay between formation routes and natural organic matter modification controls capabilities of C60 nanoparticles (nC60) to accumulate organic contaminants.

    PubMed

    Hou, Lei; Fortner, John D; Wang, Ximeng; Zhang, Chengdong; Wang, Lilin; Chen, Wei

    2017-01-01

    Accumulation of organic contaminants on fullerene nanoparticles (nC60) may significantly affect the risks of C60 in the environment. The objective of this study was to further understand how the interplay of nC60 formation routes and humic acid modification affects contaminant adsorption of nC60. Specifically, adsorption of 1,2,4,5-tetrachlorobenzene (a model nonionic, hydrophobic organic contaminant) on nC60 was greatly affected by nC60 formation route - the formation route significantly affected the aggregation properties of nC60, thus affecting the available surface area and the extent of adsorption via the pore-filling mechanism. Depending on whether nC60 was formed via the "top-down" route (i.e., sonicating C60 powder in aqueous solution) or "bottom-up" route (i.e., phase transfer from an organic solvent) and the type of solvent involved (toluene versus tetrahydrofuran), modification of nC60 with Suwannee River humic acid (SRHA) could either enhance or inhibit the adsorption affinity of nC60. The net effect depended on the specific way in which SRHA interacted with C60 monomers and/or C60 aggregates of different sizes and morphology, which determined the relative importance of enhanced adsorption from SRHA modification via preventing C60 aggregation and inhibited adsorption through blocking available adsorption sites. The findings further demonstrate the complex mechanisms controlling interactions between nC60 and organic contaminants, and may have significant implications for the life-cycle analysis and risk assessment of C60.

  20. 22 CFR 133.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... means any United States executive department, military department, government corporation, government....645 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE... the President), or any independent regulatory agency....

  1. PM2.5-induced airway inflammation and hyperresponsiveness in NC/Nga mice.

    PubMed

    Ogino, Keiki; Nagaoka, Kenjiro; Okuda, Tomoaki; Oka, Akira; Kubo, Masayuki; Eguchi, Eri; Fujikura, Yoshihisa

    2017-03-01

    The allergic inflammatory effects of particulate matter (PM) 2.5, collected with the cyclone system in Yokohama city in Japan, were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 with alum was injected intraperitoneally for sensitization. Five days later, 200 μg of PM2.5 in 25 μL of saline was administered to mice intranasally five times for further sensitization. On the 11th day, PM2.5 was administered as a challenge. On the 12th day, mice were examined for airway hyperresponsiveness (AHR), the bronchoalveolar lavage fluid (BALF) cell count, mRNA expression of Th1 , Th2 cytokines, and metallothioneins in lung tissue, and histopathology. PM2.5 increased AHR, total cell numbers including eosinophils in BALF, and mRNA levels of IL-5, IL-22, eotaxin, eotaxin 2, and metallothionein 3. In PM2.5-induced lungs, inflammation was observed around the bronchus. These results demonstrate that PM2.5 alone, collected with the cyclone system in Yokohama city in Japan, induces asthma-like airway inflammation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1047-1054, 2017.

  2. Forsythia suspensa Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice

    PubMed Central

    Sung, Yoon-Young; Yoon, Taesook; Jang, Seol; Kim, Ho Kyoung

    2016-01-01

    Forsythia suspensa (F. suspensa) is a traditional medicine for treatment of inflammation. In this study, we evaluated the therapeutic effects of an ethanol extract from F. suspensa fruits on atopic dermatitis both in vivo and in vitro. We investigated the inhibitory effects of F. suspensa extract on the development of atopic dermatitis-like skin lesions in an NC/Nga mouse model exposed to Dermatophagoides farinae crude extract. Topical application of F. suspensa extract to the mice attenuated the atopic dermatitis symptoms, including increased dermatitis severity score, ear thickness, infiltration of inflammatory cells in the skin lesions, serum levels of IgE, TNF-α, and histamine, and expression of chemokines, cytokines, and adhesion molecules in ear tissue. In addition, F. suspensa extract inhibited the production of chemokines in TNF-α/IFN-γ-activated human keratinocytes. High-performance liquid chromatography analysis of FSE revealed the presence of four chemical constituents (forsythiaside, phillyrin, pinoresinol, and phylligenin). These compounds inhibited the production of chemokines in TNF-α/IFN-γ-activated human keratinocytes. These results suggest that the F. suspensa might be a useful candidate for treating allergic skin inflammatory disorders. PMID:27936051

  3. Criticality Detection Using a Mirion Technologies DRM-2NC Remote Area Monitor Geiger-Mueller Probe

    NASA Astrophysics Data System (ADS)

    Kryskow, Adam P.

    The prompt fission neutron activation and subsequent response of a DRM-2NC Geiger-Mueller probe (manufactured by Mirion Technologies) was investigated for the purpose of creating a criticality accident detection algorithm with sensitivity and false positive suppression comparable to modern criticality accident detection systems. The expected decay pattern of secondary emissions arising from the neutron induced activity of the Geiger-Mueller probe was investigated experimentally in high neutron fluence environments at research reactors operated by the University of Massachusetts Lowell, Pennsylvania State University, and the White Sands Missile Range of Los Alamos National Laboratory. Monte Carlo techniques were used to both identify key probe materials responsible for the majority of the Geiger-Mueller response and investigate the effects of boron doping to increase detector sensitivity and enhance the signal to noise ratio. Subsequently, a statistical algorithm centered on a point weighted linear regression of the combined effective half-life was developed as the basis for criticality declaration. Final testing of the system indicated that the system was capable of meeting all ANSI criticality accident criteria with sufficient sensitivity to the minimum accident of concern, an adequate response time, and an extremely low likelihood of false alarm.

  4. Kinetics of Extracellular Peptidases in Sediments of the White Oak River, NC, USA

    NASA Astrophysics Data System (ADS)

    Steen, A. D.; Kevorkian, R. T.; Alperin, M. J.; Lloyd, K. G.

    2013-12-01

    Recent molecular work has shed light on the mechanisms underlying organoheterotrophy in the marine subsurface, including production of extracellular peptidases by deeply-branching Archaea. Here we present measurements of the potential activity (Vmax) and half-saturation constants (Km) for six extracellular peptidase substrates in sediments from 0 to 83 cm deep in the White Oak River estuary, NC, USA. Potential activities at 83 cm were on average 12% of the values at the surface, but because surface Vmax values were several orders of magnitude greater than comparable values from surface seawater, the deep activities were still substantial. Km values did not display a clear trend with depth. Activities consistent with leucyl aminopeptidase were higher than any other extracellular peptidase, but there was no clear division in activities between endopeptidases (which cleave bonds in the interior of proteins) versus aminopeptidases (which cleave N-terminal amino acids). Competitive inhibition experiments will reveal the extent to which the activities we measured reflect the distinct enzymes. We will also present model-based estimates of organic carbon mineralization rates based on methane and sulfate profiles in order to assess the relative importance of extracellular peptidases as a means to acquire organic carbon in the subsurface. Saturation curves for 5 peptidase substrates at the surface and 83 cm in the White Oak River.

  5. Forging Hispanic communities in new destinations: A case study of Durham, NC1

    PubMed Central

    Flippen, Chenoa A.; Parrado, Emilio A.

    2013-01-01

    The Chicago School of urban sociology and its extension in the spatial assimilation model have provided the dominant framework for understanding the interplay between immigrant social and spatial mobility. However, the main tenets of the theory were derived from the experience of pre-war, centralized cities; scholars falling under the umbrella of the Los Angeles school have recently challenged the extent to which they are applicable to the contemporary urban form, which is characterized by sprawling, decentralized, and multi-nucleated development. Indeed, new immigrant destinations, such as those scattered throughout the American Southeast, are both decentralized and lack prior experience with large scale immigration. Informed by this debate this paper traces the formation and early evolution of Hispanic neighborhoods in Durham, NC, a new immigrant destination. Using qualitative data we construct a social history of immigrant neighborhoods and apply survey and census information to examine the spatial pattern of neighborhood succession. We also model the sorting of immigrants across neighborhoods according to personal characteristics. Despite the many differences in urban form and experience with immigration, the main processes forging the early development of Hispanic neighborhoods in Durham are remarkably consistent with the spatial expectations from the Chicago School, though the sorting of immigrants across neighborhoods is more closely connected to family dynamics and political economy considerations than purely human capital attributes. PMID:24482612

  6. The effect of channel deepening on tides and storm surge: A case study of Wilmington, NC

    NASA Astrophysics Data System (ADS)

    Familkhalili, R.; Talke, S. A.

    2016-09-01

    In this study we investigate the hypothesis that increasing channel depth in estuaries can amplify both tides and storm surge by developing an idealized numerical model representing the 1888, 1975, and 2015 bathymetric conditions of the Cape Fear River Estuary, NC. Archival tide gauge data recovered from the U.S. National Archives indicates that mean tidal range in Wilmington has doubled to 1.55 m since the 1880s, with a much smaller increase of 0.07 m observed near the ocean boundary. These tidal changes are reproduced by simulating channel depths of 7 m (1888 condition) and 15.5 m (modern condition). Similarly, model sensitivity studies using idealized, parametric tropical cyclones suggest that the storm surge in the worst-case, CAT-5 event may have increased from 3.8 ± 0.25 m to 5.6 ± 0.6 m since the nineteenth century. The amplification in both tides and storm surge is influenced by reduced hydraulic drag caused by greater mean depths.

  7. Interacting genes that affect microtubule function in Drosophila melanogaster: Two classes of mutation revert the failure to complement between hay sup nc2 and mutations in tubulin genes

    SciTech Connect

    Regan, C.L.; Fuller, M.T. )

    1990-05-01

    The recessive male sterile mutation hay{sup nc2} of Drosophila melanogaster fails to complement certain {beta}{sub 2}-tubulin and {alpha}-tubulin mutations, suggesting that the haywire product plays a role in microtubule function, perhaps as a structural component of microtubules. The genetic interaction appears to require the presence of the aberrant product encoded by hay{sup nc2}, which may act as a structural poison. Based on this observation, the authors have isolated ten new mutations with EMS that revert the failure to complement between hay{sup nc2} and B2t{sup n}. The revertants tested behaved as intragenic mutations of hay in recombination tests, and feel into two phenotypic classes, suggesting two functional domains of the hay gene product. Some revertants were hemizygous viable and less severe than hay{sup nc2} in their recessive phenotype. These mutations might revert the poison by restoring the aberrant product encoded by the hay{sup nc2} allele to more wild-type function. Most of the revertants were recessive lethal mutations, indicating that the hay gene product is essential for viability. These more extreme mutations could revert the poison by destroying the ability of the aberrant haywire{sup nc2} product to interact structurally with microtubules. Flies heterozygous for the original hay{sup nc2} allele and an extreme revertant show defects in both the structure and the function of the male meiotic spindle.

  8. Interacting Genes That Affect Microtubule Function in Drosophila Melanogaster: Two Classes of Mutation Revert the Failure to Complement between Hay(nc2) and Mutations in Tubulin Genes

    PubMed Central

    Regan, C. L.; Fuller, M. T.

    1990-01-01

    The recessive male sterile mutation hay(nc2) of Drosophila melanogaster fails to complement certain β(2)-tubulin and α-tubulin mutations, suggesting that the haywire product plays a role in microtubule function, perhaps as a structural component of microtubules. The genetic interaction appears to require the presence of the aberrant product encoded by hay(nc2), which may act as a structural poison. Based on this observation, we have isolated ten new mutations that revert the failure to complement between hay(nc2) and B2t(n). The revertants tested behaved as intragenic mutations of hay in recombination tests, and fell into two phenotypic classes, suggesting two functional domains of the hay gene product. Some revertants were hemizygous viable and less severe than hay(nc2) in their recessive phenotype. These mutations might revert the poison by restoring the aberrant product encoded by the hay(nc2) allele to more wild-type function. Most of the revertants were recessive lethal mutations, indicating that the hay gene product is essential for viability. These more extreme mutations could revert the poison by destroying the ability of the aberrant haywire(nc2) product to interact structurally with microtubules. Flies heterozygous for the original hay(nc2) allele and an extreme revertant show defects in both the structure and the function of the male meiotic spindle. PMID:2111265

  9. 40 CFR 1508.16 - Lead agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Lead agency. 1508.16 Section 1508.16 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.16 Lead agency. Lead agency means the agency or agencies preparing or having taken primary responsibility for preparing...

  10. 40 CFR 1508.5 - Cooperating agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Cooperating agency. 1508.5 Section 1508.5 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.5 Cooperating agency. Cooperating agency means any Federal agency other than a lead agency which...

  11. 76 FR 1523 - New Agency Logos

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... logo. This logo is for use on agency letterhead, all agency social media sites, and other agency... agency logo is used: (1) On agency letterhead and business cards; (2) On all NARA web and social media... and publicity media. The other three logos are for new offices within NARA--the Office of...

  12. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  13. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  14. 40 CFR 1508.16 - Lead agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Lead agency. 1508.16 Section 1508.16 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.16 Lead agency. Lead agency means the agency or agencies preparing or having taken primary responsibility for preparing...

  15. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  16. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  17. 40 CFR 1508.16 - Lead agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Lead agency. 1508.16 Section 1508.16 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.16 Lead agency. Lead agency means the agency or agencies preparing or having taken primary responsibility for preparing...

  18. 40 CFR 1508.16 - Lead agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Lead agency. 1508.16 Section 1508.16 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.16 Lead agency. Lead agency means the agency or agencies preparing or having taken primary responsibility for preparing...

  19. 40 CFR 1508.16 - Lead agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Lead agency. 1508.16 Section 1508.16 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.16 Lead agency. Lead agency means the agency or agencies preparing or having taken primary responsibility for preparing...

  20. Radiation Information from Other Agencies

    EPA Pesticide Factsheets

    EPA does not license nuclear power plants or regulate the non-ionizing radiation from cell phones, smart meters or power lines. This page provides links to the state and Federal agencies that regulate these matters.

  1. Administering Our State Library Agencies

    ERIC Educational Resources Information Center

    DuFrane, Gerard

    1970-01-01

    A satire on the application of scientific management principles to a state library agency. Covers relationships of the state librarian to staff, the profession, and state and federal governments. (Author/JS)

  2. Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease.

    PubMed Central

    Sheng, N; Pettit, S C; Tritch, R J; Ozturk, D H; Rayner, M M; Swanstrom, R; Erickson-Viitanen, S

    1997-01-01

    During human immunodeficiency virus type 1 (HIV-1) virion assembly, cleavage of the Gag precursor by the viral protease results in the transient appearance of a nucleocapsid-p1-p6 intermediate product designated p15NC. Utilizing the p15NC precursor protein produced with an in vitro transcription-translation system or purified after expression in Escherichia coli, we have demonstrated that RNA is required for efficient cleavage of HIV p15NC. Gel mobility shift and nitrocellulose filter binding experiments indicate that purified p15NC protein specifically binds its corresponding mRNA with an estimated Kd of 1.5 nM. Binding was not affected by the presence or absence of zinc or EDTA. Moreover, mutagenesis of the cysteine residues within either of the two Cys-His arrays had no effect on RNA binding or on RNA-dependent cleavage by the viral protease. In contrast, decreased binding of RNA and diminished susceptibility to cleavage in vitro were observed with p15NC-containing mutations in one or more residues within the triplet of basic amino acids present in the region between the two zinc fingers. In addition, we found that 21- to 24-base DNA and RNA oligonucleotides of a particular sequence and secondary structure could substitute for p15 RNA in the enhancement of p15NC cleavage. Virus particles carrying a mutation in the triplet of NC basic residues (P3BE) show delayed cleavage of p15NC and a defect in core formation despite the eventual appearance of fully processed virion protein. These results define determinants of the p15NC-RNA interaction that lead to enhanced protease-mediated cleavage and demonstrate the importance of the triplet of basic residues in formation of the virus core. PMID:9223458

  3. Genetic engineering and autonomous agency.

    PubMed

    Barclay, Linda

    2003-01-01

    In this paper I argue that the genetic manipulation of sexual orientation at the embryo stage could have a detrimental effect on the subsequent person's later capacity for autonomous agency. By focussing on an example of sexist oppression I show that the norms and expectations expressed with this type of genetic manipulation can threaten the development of autonomous agency and the kind of social environment that makes its exercise likely.

  4. Tank Tests of a Model of the NC Flying-boat Hull - N.A.C.A. Model 44

    NASA Technical Reports Server (NTRS)

    Bell, Joe W

    1936-01-01

    A 1/7.06 full-size model of the NC-type hull was tested in the N.A.C.A. tank by both the general method and the specific or free-to-trim method. The results of the tests are given in curves plotted as non dimensional coefficients and are compared with the test results of N.A.C.A. model 11-A. The NC model (N.A.C.A. model 44) shows higher resistance than model 11-A at hump speed but lower resistance at high speeds. Model 44 has a higher best trim angle at the jump and a lower maximum positive trimming moment than model 11-A. At high speeds the best trim angle and the trimming moments of the two models are approximately the same.

  5. PREFACE: NC-AFM 2004: Proceedings of the 7th International Conference on Non-contact Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Schwarz, Udo

    2005-03-01

    With the ongoing miniaturization of devices and controlled nanostructuring of materials, the importance of atomic-scale information on surfaces and surface properties is growing continuously. The astonishing progress in nanoscience and nanotechnology that took place during the last two decades was in many ways related to recent progress in high-resolution imaging techniques such as scanning tunnelling microscopy and transmission electron microscopy. Since the mid-1990s, non-contact atomic force microscopy (NC-AFM) performed in ultrahigh vacuum has evolved as an alternative technique that achieves atomic resolution, but without the restriction to conducting surfaces of the previously established techniques. Advances of the rapidly developing field of NC-AFM are discussed at annual conferences as part of a series that started in 1998 in Osaka, Japan. This special issue of Nanotechnology is a compilation of original work presented at the 7th International Conference on Non-contact Atomic Force Microscopy that took place in Seattle, USA, 12-15 September 2004. Over the years, the conference grew in size and scope. Atomic resolution imaging of oxides and semiconductors remains an issue. Noticeable new developments have been presented in this regard such as, e.g., the demonstrated ability to manipulate individual atoms. Additionally, the investigation of individual molecules, clusters, and organic materials gains more and more attention. In this context, considerable effort is undertaken to transfer the NC-AFM principle based on frequency modulation to applications in air and liquids with the goal of enabling high-resolution surface studies of biological material in native environments, as well as to reduce the experimental complexity, which so far involves the availability of (costly) vacuum systems. Force spectroscopy methods continue to be improved and are applied to topics such as the imaging of the three-dimensional force field as a function of the distance with

  6. The Yfr2 ncRNA family, a group of abundant RNA molecules widely conserved in cyanobacteria.

    PubMed

    Gierga, Gregor; Voss, Björn; Hess, Wolfgang R

    2009-01-01

    Sequence signatures, predicted secondary structures and experimental data suggest the Yfr2 family of non-coding RNAs (ncRNAs) to be present in nearly all cyanobacteria sequenced to date. The common features of the family members include a central consensus element (CCE), 5'-RKT SGA AAC WHG GHM ASA M-3', predicted to form a 12 nt single stranded region plus a short helical region consisting of three base pairs and one unpaired nucleotide that is either bulging or the begin of a short internal loop. Yfr2 family members are 63 to 100 nucleotides in size and they share a conserved region at the 5' end, starting with 5'-GUGAGGA-3' or a closely related motif. The genes for ncRNAs of this family are suggested to exist in highly variable copy numbers in the individual genomes, with up to nine copies in some marine Synechococcus.

  7. 1 + 1 Large Nc QCD and its Holographic Dual˜Soliton Picture of Baryons in Single-Flavor World

    NASA Astrophysics Data System (ADS)

    Suganuma, Hideo; Nakagawa, Yuya; Matsumoto, Kohei

    We study baryons in holographic QCD corresponding to 1 + 1 dimensional single-flavor (Nf = 1) QCD for the first time. We formulate 1 + 1 QCD using an S1-compactified D2/D8/overline{D8} branes in the superstring theory, and describe the baryon as a topological configuration in 1 + 1 Nf = 1 QCD, corresponding to Π1(U(1)) = Z. Unlike 1 + 3 QCD with Nf ≥ 2, however, we find that the low-dimensional baryonic soliton is generally unstable against a scale transformation/variation and swells infinitely in 1 + 1 Nf = 1 QCD at the leading of large Nc. We thus point out a serious difficulty on the soliton picture of baryons in large Nc in the single-flavor world in both 1 + 1 and 1 + 3 QCD. We also compare the low-dimensional holographic baryon with the Abrikosov vortex, i.e., a stable topological configuration in Type-II superconductors.

  8. Radiation Induced Enhancement of Hydrogen Influence on Luminescent Properties of nc-Si/SiO2 Structures

    NASA Astrophysics Data System (ADS)

    Lisovskyy, Igor; Voitovych, Mariia; Litovchenko, Volodymyr; Voitovych, Vasyl; Nasieka, Iurii; Bratus, Viktor

    2016-12-01

    Using photo-luminescence, infrared spectroscopy, and electron spin resonance technique, the silicon dioxide films with embedded silicon nanocrystals (nc-Si/SiO2 structures) have been investigated after γ-irradiation with the dose 2 × 107 rad and subsequent annealing at 450 °C in hydrogen ambient. For the first time, it was shown that such a radiation-thermal treatment results in significant increase of the luminescence intensity, in a red shift of the photoluminescence spectra, and in disappearance of the electron-spin resonance signal related to silicon broken bonds. This effect has been explained by passivation of silicon broken bonds at the nc-Si-SiO2 interface with hydrogen and by generation of new luminescence centers, these centers being created at elevated temperatures due to transformation of radiation-induced defects.

  9. Effect of substrate morphology slope distributions on light scattering, nc-Si:H film growth, and solar cell performance.

    PubMed

    Kim, Do Yun; Santbergen, Rudi; Jäger, Klaus; Sever, Martin; Krč, Janez; Topič, Marko; Hänni, Simon; Zhang, Chao; Heidt, Anna; Meier, Matthias; van Swaaij, René A C M M; Zeman, Miro

    2014-12-24

    Thin-film silicon solar cells are often deposited on textured ZnO substrates. The solar-cell performance is strongly correlated to the substrate morphology, as this morphology determines light scattering, defective-region formation, and crystalline growth of hydrogenated nanocrystalline silicon (nc-Si:H). Our objective is to gain deeper insight in these correlations using the slope distribution, rms roughness (σ(rms)) and correlation length (lc) of textured substrates. A wide range of surface morphologies was obtained by Ar plasma treatment and wet etching of textured and flat-as-deposited ZnO substrates. The σ(rms), lc and slope distribution were deduced from AFM scans. Especially, the slope distribution of substrates was represented in an efficient way that light scattering and film growth direction can be more directly estimated at the same time. We observed that besides a high σ(rms), a high slope angle is beneficial to obtain high haze and scattering of light at larger angles, resulting in higher short-circuit current density of nc-Si:H solar cells. However, a high slope angle can also promote the creation of defective regions in nc-Si:H films grown on the substrate. It is also found that the crystalline fraction of nc-Si:H solar cells has a stronger correlation with the slope distributions than with σ(rms) of substrates. In this study, we successfully correlate all these observations with the solar-cell performance by using the slope distribution of substrates.

  10. Superscaling in electron-nucleus scattering and its link to CC and NC QE neutrino-nucleus scattering

    SciTech Connect

    Barbaro, M. B.; Amaro, J. E.; Caballero, J. A.; González-Jiménez, R.; Donnelly, T. W.; Ivanov, M.; Udías, J. M.

    2015-05-15

    The superscaling approach (SuSA) to neutrino-nucleus scattering, based on the assumed universality of the scaling function for electromagnetic and weak interactions, is reviewed. The predictions of the SuSA model for bot CC and NC differential and total cross sections are presented and compared with the MiniBooNE data. The role of scaling violations, in particular the contribution of meson exchange currents in the two-particle two-hole sector, is explored.

  11. Toxoplasma gondii Infection Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice

    PubMed Central

    Jeong, Young-Il; Hong, Sung-Hee; Cho, Shin-Hyeong; Lee, Won-Ja

    2015-01-01

    Purpose Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects humans and animals via congenital or postnatal routes, and it is found worldwide. Modulation of the immune system by parasite infection is proposed to suppress allergic inflammation. Growing evidences have shown that interleukin (IL)-10-producing regulatory B cells (Bregs) and CD4+CD25+FoxP3+ regulatory T cells (Tregs) induced by parasite infection play a critical role in allergic or autoimmune diseases because these cells regulate negatively cellular immune responses and inflammation. Currently, the role of IL-10-producing regulatory B cells in host immune response during T. gondii infection is unknown. In this study, we investigate whether T. gondii infection can suppress the development of unrelated atopic dermatitis (AD)-like lesions. Methods AD is a chronically relapsing inflammatory skin disease accompanied by severe itching; for this, we used NC/Nga mice, a well-known experimental model of systemic AD. Repeated exposure to Dermatophagoides farinae crude extract (DfE), known as a major environmental allergen, evokes AD-like skin lesions in NC/Nga mice under specific pathogen-free conditions. NC/Nga mice were intraperitoneally infected with 10 cysts of T. gondii. Results T. gondii infection significantly ameliorated AD-like skin lesions in NC/Nga mice. The subpopulation of Bregs and Tregs in the AD mice was expanded in the course of T. gondii infection. In addition, T. gondii infection inhibited Th2 and enhanced Th1 immune response in the DfE-treated AD mice. Conclusions We have experimentally demonstrated for the first time that T. gondii infection ameliorated AD-like skin lesions in a mouse model of AD. Our study could in part explain the mechanisms of how parasite infection prevents the development of allergic disorder. Therefore, these immunemechanisms induced by T. gondii infection may be beneficial for the host in terms of reduced risk of allergic immune

  12. Polarized Raman study of [N(C3H7)4]2Cd2Cl6 single crystal.

    PubMed

    Hannachi, N; Guidara, K; Bulou, A; Gargouri, M; Hlel, F

    2010-10-01

    Chemical preparation, mid-infrared and Raman spectra of [N(C(3)H(7))(4)](2)Cd(2)Cl(6) are presented. Polarized Raman spectra of oriented single crystals have been recorded in the range 7-3900 cm(-1) under various polarization configurations with regard to the symmetry and the numbers of several band modes observed in the Raman and infrared spectra. The obtained results are consistent with the theoretical predictions based on the infrared and Raman selection rules.

  13. Λc(2595 ) resonance as a dynamically generated state: The compositeness condition and the large Nc evolution

    NASA Astrophysics Data System (ADS)

    Lu, Jun-Xu; Chen, Hua-Xing; Guo, Zhi-Hui; Nieves, J.; Xie, Ju-Jun; Geng, Li-Sheng

    2016-06-01

    Recent studies have shown that the well-established Λc(2595 ) resonance contains a large meson-baryon component, which can vary depending on the specific formalism. In this work, we examine such a picture by utilizing the compositeness condition and the large number of colors (Nc) expansion. We examine three different models fulfilling two body unitarity in coupled-channels, and adopting renormalization schemes where the mass of the Λc(2595 ) resonance is well described, but not necessarily its width, since we do not consider three body channels and work at the isospin symmetric limit. Both approximations might have an effect larger on the width than on the mass. In this context, our studies show that the compositeness of the Λc(2595 ) depends on the number of considered coupled channels, and on the particular regularization scheme adopted in the unitary approaches and, therefore, is model dependent. In addition, we perform an exploratory study of the Λc(2595 ) in the large Nc expansion, within a scheme involving only the π Σc and K Ξc' channels, whose dynamics is mostly fixed by chiral symmetry. In this context and formulating the leading-order interaction as a function of Nc, we show that for moderate Nc>3 values, the mass and width of the Λc(2595 ) deviate from those of a genuine q q q baryon, implying the relevance of meson-baryon components in its wave function. Furthermore, we study the properties of the Λc(2595 ), in the strict Nc→∞ limit, using an extension of the chiral Weinberg-Tomozawa interaction to an arbitrary number of flavors and colors. This latter study hints at the possible existence of a (perhaps) subdominant q q q component in the Λc(2595 ) resonance wave function, which would become dominant when the number of colors gets sufficiently large.

  14. Superscaling in electron-nucleus scattering and its link to CC and NC QE neutrino-nucleus scattering

    NASA Astrophysics Data System (ADS)

    Barbaro, M. B.; Amaro, J. E.; Caballero, J. A.; Donnelly, T. W.; González-Jiménez, R.; Ivanov, M.; Udías, J. M.

    2015-05-01

    The superscaling approach (SuSA) to neutrino-nucleus scattering, based on the assumed universality of the scaling function for electromagnetic and weak interactions, is reviewed. The predictions of the SuSA model for bot CC and NC differential and total cross sections are presented and compared with the MiniBooNE data. The role of scaling violations, in particular the contribution of meson exchange currents in the two-particle two-hole sector, is explored.

  15. 49 CFR Attachment 3 - Offices Within Federal Agencies and Federal-State Agencies for Information Regarding the Agencies...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Attachment 3 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC.... Attachment 3—Offices Within Federal Agencies and Federal-State Agencies for Information Regarding...

  16. Development of maskless electron-beam lithography using nc-Si electron-emitter array

    NASA Astrophysics Data System (ADS)

    Kojima, A.; Ikegami, N.; Yoshida, T.; Miyaguchi, H.; Muroyama, M.; Nishino, H.; Yoshida, S.; Sugata, M.; Cakir, S.; Ohyi, H.; Koshida, N.; Esashi, M.

    2013-03-01

    This study demonstrated our prototyped Micro Electro Mechanical System (MEMS) electron emitter which is a nc-Si (nanocrystalline silicon) ballistic electron emitter array integrated with an active-matrix driving LSI for high-speed Massively Parallel Electron Beam Direct Writing (MPEBDW) system. The MPEBDW system consists of the multi-column, and each column provides multi-beam. Each column consists of emitter array, a MEMS condenser lens array, an MEMS anode array, a stigmator, three-stage deflectors to align and to scan the multi beams, and a reduction lens as an objective lens. The emitter array generates 100x100 electron beams with binary patterns. The pattern exposed on a target is stored in one of the duplicate memories in the active matrix LSI. After the emission, each electron beam is condensed into narrow beam in parallel to the axis of electron optics of the system with the condenser lens array. The electrons of the beams are accelerated and pass through the anode array. The stigmator and deflectors make fine adjustments to the position of the beams. The reduction lens in the final stage focuses all parallel beams on the surface of the target wafer. The lens reduces the electron image to 1%-10% in size. Electron source in this system is nc-Si ballistic surface electron emitter. The characteristics of the emitter of 1:1 projection of e-beam have been demonstrated in our previous work. We developed a Crestec Surface Electron emission Lithography (CSEL) for mass production of semiconductor devices. CSEL system is 1:1 electron projection lithography using surface electron emitter. In first report, we confirmed that a test bench of CSEL resolved below 30 nm pattern over 0.2 um square area. Practical resolution of the system is limited by the chromatic aberration. We also demonstrated the CSEL system exposed deep sub-micron pattern over full-field for practical use. As an interim report of our development of MPEBDW system, we evaluated characteristics of the

  17. Fabrication Technology and Characteristics of a Magnetic Sensitive Transistor with nc-Si:H/c-Si Heterojunction

    PubMed Central

    Zhao, Xiaofeng; Li, Baozeng; Wen, Dianzhong

    2017-01-01

    This paper presents a magnetically sensitive transistor using a nc-Si:H/c-Si heterojunction as an emitter junction. By adopting micro electro-mechanical systems (MEMS) technology and chemical vapor deposition (CVD) method, the nc-Si:H/c-Si heterojunction silicon magnetically sensitive transistor (HSMST) chips were designed and fabricated on a p-type <100> orientation double-side polished silicon wafer with high resistivity. In addition, a collector load resistor (RL) was integrated on the chip, and the resistor converted the collector current (IC) to a collector output voltage (Vout). When IB = 8.0 mA, VDD = 10.0 V, and RL = 4.1 kΩ, the magnetic sensitivity (SV) at room temperature and temperature coefficient (αC) of the collector current for HSMST were 181 mV/T and −0.11%/°C, respectively. The experimental results show that the magnetic sensitivity and temperature characteristics of the proposed transistor can be obviously improved by the use of a nc-Si:H/c-Si heterojunction as an emitter junction. PMID:28117744

  18. Fabrication Technology and Characteristics of a Magnetic Sensitive Transistor with nc-Si:H/c-Si Heterojunction.

    PubMed

    Zhao, Xiaofeng; Li, Baozeng; Wen, Dianzhong

    2017-01-22

    This paper presents a magnetically sensitive transistor using a nc-Si:H/c-Si heterojunction as an emitter junction. By adopting micro electro-mechanical systems (MEMS) technology and chemical vapor deposition (CVD) method, the nc-Si:H/c-Si heterojunction silicon magnetically sensitive transistor (HSMST) chips were designed and fabricated on a p-type <100> orientation double-side polished silicon wafer with high resistivity. In addition, a collector load resistor ( R L ) was integrated on the chip, and the resistor converted the collector current ( I C ) to a collector output voltage ( V out ). When I B = 8.0 mA, V DD = 10.0 V, and R L = 4.1 kΩ, the magnetic sensitivity ( S V ) at room temperature and temperature coefficient ( α C ) of the collector current for HSMST were 181 mV/T and -0.11%/°C, respectively. The experimental results show that the magnetic sensitivity and temperature characteristics of the proposed transistor can be obviously improved by the use of a nc-Si:H/c-Si heterojunction as an emitter junction.

  19. Modeling the transport and retention of nC60 nanoparticles in the subsurface under different release scenarios.

    PubMed

    Bai, Chunmei; Li, Yusong

    2012-08-01

    The escalating production and consumption of engineered nanomaterials may lead to their increased release into groundwater. A number of studies have revealed the potential human health effects and aquatic toxicity of nanomaterials. Understanding the fate and transport of engineered nanomaterials is very important for evaluating their potential risks to human and ecological health. While there has been a great deal of research effort focused on the potential risks of nanomaterials, a limited amount of work has evaluated the transport of engineered nanomaterials under different release scenarios in a typical layered geological field setting. In this work, we simulated the transport of fullerene aggregates (nC(60)), a widely used engineered nanomaterial, in a multi-dimensional environment. A Modular Three-Dimensional Multispecies Transport Model (MT3DMS) was modified to evaluate the transport and retention of nC(60) nanoparticles. Hypothetical scenarios for the introduction of nanomaterials into the subsurface environment were investigated, including the release from an injection well and the release from a waste site. Under the conditions evaluated, the mobility of nC(60) nanoparticles was found to be very sensitive to the release scenario, release concentration, aggregate size, collision efficiency factor, and dispersivity of the nanomaterial.

  20. Modeling the transport and retention of nC60 nanoparticles in the subsurface under different release scenarios

    NASA Astrophysics Data System (ADS)

    Bai, Chunmei; Li, Yusong

    2012-08-01

    The escalating production and consumption of engineered nanomaterials may lead to their increased release into groundwater. A number of studies have revealed the potential human health effects and aquatic toxicity of nanomaterials. Understanding the fate and transport of engineered nanomaterials is very important for evaluating their potential risks to human and ecological health. While there has been a great deal of research effort focused on the potential risks of nanomaterials, a limited amount of work has evaluated the transport of engineered nanomaterials under different release scenarios in a typical layered geological field setting. In this work, we simulated the transport of fullerene aggregates (nC60), a widely used engineered nanomaterial, in a multi-dimensional environment. A Modular Three-Dimensional Multispecies Transport Model (MT3DMS) was modified to evaluate the transport and retention of nC60 nanoparticles. Hypothetical scenarios for the introduction of nanomaterials into the subsurface environment were investigated, including the release from an injection well and the release from a waste site. Under the conditions evaluated, the mobility of nC60 nanoparticles was found to be very sensitive to the release scenario, release concentration, aggregate size, collision efficiency factor, and dispersivity of the nanomaterial.

  1. Real geometry gyrokinetic PIC computations of ion turbulence in tokamak discharges with SUMMIT/PG3EQ_NC

    NASA Astrophysics Data System (ADS)

    Leboeuf, Jean-Noel; Rhodes, Terry; Dimits, Andris; Shumaker, Dan

    2006-10-01

    The PG3EQ_NC module within the SUMMIT Gyrokinetic PIC FORTRAN90 Framework makes possible 3D nonlinear toroidal computations of ion turbulence in the real geometry of DIII-D discharges. This is accomplished with the use of local, field line following, quasi-ballooning coordinates and through a direct interface with DIII-D equilibrium data via the EFIT and ONETWO codes, as well as Holger Saint John's PLOTEQ code for the (R, Z) position of each flux surface. The effect of real geometry is being elucidated with CYCLONE shot by comparing results for growth rates and diffusivities from PGEQ_NC to those of its circular counterpart. The PG3EQ_NC module is also being used to model ion channel turbulence in DIII-D discharges 118561 and 120327. Linear results will be compared to growth rate calculations with the GKS code. Nonlinear results will also be compared with scattering measurements of turbulence, as well as with accessible measurements of fluctuation amplitudes and spectra from other diagnostics.

  2. Real geometry gyrokinetic PIC computations of ion turbulence in advanced tokamak discharges with SUMMIT/PG3EQ_/NC

    NASA Astrophysics Data System (ADS)

    Leboeuf, Jean-Noel; Decyk, Viktor; Rhodes, Terry; Dimits, Andris; Shumaker, Dan

    2006-04-01

    The PG3EQ_/NC module within the SUMMIT Gyrokinetic PIC FORTRAN90 Framework makes possible 3D nonlinear toroidal computations of ion turbulence in the real geometry of DIII-D discharges. This is accomplished with the use of local, field line following, quasi-ballooning coordinates and through a direct interface with DIII-D equilibrium data via the EFIT and ONETWO codes, as well as Holger Saint John's PLOTEQ code for the (R, Z) position of each flux surface. The effect of real geometry is being elucidated with CYCLONE shot 81499 by comparing results from PGEQ_/NC to those of its circular counterpart. The PG3EQ_/NC module is also being used to model ion channel turbulence in advanced tokamak discharges 118561 and 120327. Linear results will be compared to growth rate calculations with the GKS code. Nonlinear results will also be compared with scattering measurements of turbulence, as well as with accessible measurements of fluctuation amplitudes and spectra from other diagnostics.

  3. Mucosal Tolerance Induced by an Immunodominant Peptide from Rat α3(IV)NC1 in Established Experimental Autoimmune Glomerulonephritis

    PubMed Central

    Reynolds, John; Abbott, Danielle S.; Karegli, Julieta; Evans, David J.; Pusey, Charles D.

    2009-01-01

    Experimental autoimmune glomerulonephritis (EAG), an animal model of Goodpasture’s disease, can be induced in Wistar Kyoto (WKY) rats by immunization with the noncollagenous domain of the α 3 chain of type IV collagen, α3(IV)NC1. Recent studies have identified an immunodominant peptide, pCol (24-38), from the N-terminus of rat α3(IV)NC1; this peptide contains the major B- and T-cell epitopes in EAG and can induce crescentic nephritis. In this study, we investigated the mechanisms of mucosal tolerance in EAG by examining the effects of the nasal administration of this peptide after the onset of disease. A dose-dependent effect was observed: a dose of 300 μg had no effect, a dose of 1000 μg resulted in a moderate reduction in EAG severity, and a dose of 3000 μg produced a marked reduction in EAG severity accompanied by diminished antigen-specific, T-cell proliferative responses. These results demonstrate that mucosal tolerance in EAG can be induced by nasal administration of an immunodominant peptide from the N-terminus of α3(IV)NC1 and should be of value in designing new therapeutic strategies for patients with Goodpasture’s disease and other autoimmune disorders. PMID:19406992

  4. Derivation of Transport Equations for a Strongly Interacting Lagrangian in Powers of ħand 1/ Nc

    NASA Astrophysics Data System (ADS)

    Klevansky, S. P.; Ogura, A.; Hüfner, J.

    1997-11-01

    Transport theory for an interacting fermionic system is reviewed and applied to the chiral Lagrangian of the Nambu-Jona-Lasinio model. Two expansions must be applied: an expansion in the inverse number of colors, 1/Nc, due to the nature of the strong coupling theory, and a semiclassical expansion, in powers of ħ. The quasiparticle approximation is implemented at an early stage, and spin effects are omitted. The self-energy is evaluated, self-consistently only in the Hartree approximation, and semi-perturbatively in the collision integral. In the Hartree approximation,O((1/Nc)0), the Vlasov equation is recovered toO(ħ1), together with an on-mass shell constraint equation, that is automatically fulfilled by the quasiparticle ansatz. The expressions for the self-energy to orderO((1/Nc)) lead to the collision term. Here one sees explicitly that particle-antiparticle creation and annihilation processes are suppressed that would otherwise be present, should an off-shell energy spectral function be admitted. A clear identification of thes,tanduchannel scattering processes in connection with the self-energy graphs is made and the origin of the mixed terms is made evident. Finally, after ordering according to powers in ħ, a Boltzmann-like form for the collision integral is obtained.

  5. Band-gap states in unfilled mesoporous nc-TiO2: measurement protocol for electrical characterization

    NASA Astrophysics Data System (ADS)

    Cultrera, A.; Boarino, L.; Amato, G.; Lamberti, C.

    2014-01-01

    The characterization of the intrinsic electrical properties of large surface area materials such as mesoporous nanocrystalline (nc-TiO2), requires one to avoid sensor-like responses to external agents. Both an appropriate sample configuration and a suitable measurement protocol are mandatory. In this work, both the stack and planar contacts configurations were studied, the latter giving evidence which is potentially useful for space charge limited (SCL) current investigations in order to study the band-gap states (BGSs) properties in nc-TiO2. Moreover, in the absence of a suitable measurement protocol, standard dye sensitized solar cells (DSSCs) electrode films show apparent SCL current behaviour, as a consequence of the surface electrical transport contribution due to the physisorbed water on the hydroxylated metal oxide large surface area. This feature recalls the typical results of electrolyte filled systems, in which an exponential distribution of trap states is reported; it is not expected to be an intrinsic feature of the nc-TiO2 trap states distribution. In the absence of adsorbates, no deviation from an ohmic regime is observed in standard electrodes, while in planar configuration samples, the SCL regime is accessible and shows a different BGS signature. The nature of electrical contacts, ohmic in this situation, is also discussed.

  6. Study of the X~2Π state of the SiCN/SiNC Renner-Teller system

    NASA Astrophysics Data System (ADS)

    Brites, Vincent; Mitrushchenkov, Alexander O.; Léonard, Céline

    2013-03-01

    The potential energy surfaces of both components of the tildeX^2Π electronic ground state of the double Renner-Teller SiCN/SiNC system are calculated using explicitly correlated coupled cluster approach. The SiNC minimum is found to lie at 628 cm-1 above the SiCN one. The isomerization transition state is found at 7583 cm-1 on the 2A' surface and at 7936 cm-1 on the 2A″ surface. The cyclic local minimum on surface 2A' is also reproduced by our potential energy surface and is located at 3901 cm-1. The calculated potentials are used to simulate rovibrational spectroscopy employing the recently developed EVEREST variational code. It is shown that Renner-Teller interaction (ɛ = 0.3043 for SiCN and ɛ = 0.3874 for SiNC) and spin-orbit coupling are both very important for a correct description of the spectroscopy of this system. Comparison with available experimental measurement is reported.

  7. Enhanced lysis of herpes simplex virus type 1-infected mouse cell lines by NC and NK effectors

    SciTech Connect

    Colmenares, C.; Lopez, C.

    1986-05-01

    Spontaneously cytotoxic murine lymphocytes lysed certain cell types infected by herpes simplex virus type 1 (HSV-1) better than uninfected cells. Although HSV-1 adsorbed to the surface of all the target cells, those in which the virus replicated more efficiently were lysed to a greater extent. As targets, the authors used cell lines that, when uninfected, were spontaneously lysed by NK cells (YAC-1) or by NC cells (WEHI-164). They also used a fibroblastoid cell line (M50) and a monocytic tumor line (PU51R), which were not spontaneously killed. NK cells lysed HSV-1-infected YAC cells better than uninfected cells, and an NC-like activity selectively lysed HSV-1-infected WEHI cells. These findings were consistent with the results of experiments performed to define the role of interferon in induction of virus-augmented cytolysis. Increased lysis of YAC-HSV and PU51R-HSV was entirely due to interferon activation and was completely abolished by performing the /sup 51/Cr-release assay in the presence of anti-interferon serum. The data show that HSV-1 infection of NK/NC targets induces increased cytotoxity, but the effector cell responsible for lysis is determined by the uninfected target, or by an interaction between the virus and target cell, rather than by a viral determinant alone.

  8. Enhancing Parent Involvement in NC-CCSS for K-2 Mathematics

    NASA Astrophysics Data System (ADS)

    Johnson, D.

    2014-12-01

    Key Terms:Parent Involvement, Common Core State Standards, Homework, K - 2 Mathematics In this study, the 2014 REU math team developed and provided a workshop that assisted parents in understanding the North Carolina Common Core State Standards for K-2 Mathematics to assist with student homework assignments. Parent involvement is defined as parent participating in the educational processes and experiences of their children. A chi-square analysis was used to analyze data collected from the pre survey and the post survey administered to participants in the workshop. The study revealed all of the individual components of parent involvement were positively and significantly related to educational goals. The study identified various aspects of parent involvement that yielded statistically significant results in affirming that parent involvement attributed to urban student achievement. These findings were particularly helpful for indicating which kinds of parent involvement influenced academic success. Most notably, parent expectations and styles demonstrated a strong relationship with scholastic outcomes. Parent expectations and styles created an educationally oriented ambience that established an understanding of the certain level of support the child needed to succeed academically. The REU mathematics team focused on three essential questions in this study: (1) What practices will increase parent awareness of K-2 NC-CCSS for mathematics at P. W. Moore Elementary School? (2) What methods can be used to strengthen parent skills in assisting with mathematics homework assignments at P. W. Moore Elementary School? (3) What actions can be taken to motivate parent involvement in the school improvement process focusing on mathematics at P. W. Moore Elementary School?

  9. A benthic carbon budget for the continental slope off Cape Hatteras, N.C.

    SciTech Connect

    Thomas, C.J.; Blair, N.E.; DeMaster, D.J.; Jahnke, R.A.; Martens, C.S.

    1999-01-31

    The continental slope off Cape Hatteras, N.C. from approximately 36{degree} 00 minutes N to 35{degree} 20 minutes N is a region of relatively rapid sediment accumulation, organic matter deposition and subsequent remineralization. The measured fluxes are the highest reported for the slope off the eastern US Sediment accumulation rates range from 40 to 140 cm ky{sup -1}. Organic carbon deposition rates range from 3.5 to 7.4 moles C m{sup -2} yr{sup -1}. The areal coverage of this ''depocenter'' is probably controlled by interactions between physical oceanographic processes and the rugged topography of the seafloor. The organic matter deposited on the seafloor is primarily marine in origin and a mix of old and fresh particles. 73-93% of the depositing detritus is rapidly oxidized near the sediment/water interface. The controls on subsurface remineralization appear to be a complex function of the relative amount of metabolizable carbon delivered to the seabed both now and in the distant past (>=500ybp) and the extent of seabed irrigation. The age of DIC and CH{sub 4} produced within the seabed indicates that relatively young, reactive carbon is advected below the sediment surface and fuels subsurface remineralization. The stable isotopic composition of DIC produced within the seabed indicates the selective degradation of {sup 13}C-enriched fractions of the organic matter. The metabolizable fraction has a carbon isotopic signature of approx. -18{per_thousand};, while the organic matter that survives degradation and is buried has a d{sup 13}C closer to -20{per_thousand}.

  10. Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice

    PubMed Central

    Saba, Evelyn; Lee, Chun Hee; Jeong, Da Hye; Lee, Kija; Kim, Tae-Hwan; Roh, Seong-Soo; Kim, Seung-Hyung; Rhee, Man Hee

    2016-01-01

    Abstract The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. In our study, rice bran along with oriental medicinal plants (Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia deserticola (FRBE). We evaluated the effects of oral administration of FRBE on atopic dermatitis in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count. In addition, it reduced skin thickness compared to that of atopic dermatitis-affected skin. FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis. The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application, and this was normalized by FRBE treatment. Moreover, it decreased the levels of CD8+ helper T cells and Gr-1+/CD11b+ B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis. Using real-time polymerase chain reaction analysis, we demonstrated that FRBE significantly inhibited mRNA expression of cytokines (e.g., interleukin-5 and interleukin-13) and cyclooxygenase-2 in AD skin lesions. These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis. PMID:27323667

  11. 78 FR 13333 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... the use of automated collection techniques or other forms of information technology. DATES: Comments.... Energy Information Administration Agency Information Collection Extension AGENCY: U.S. Energy Information Administration (EIA), Department of Energy (DOE). ACTION: Agency Information Collection Activities:...

  12. 77 FR 66834 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... and Federal agencies. The emergency exemptions may take the following form: Crisis, public health... AGENCY Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations.... ``Quarantine'' and ``public health'' exemptions are emergency exemptions issued for quarantine or public...

  13. Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes

    PubMed Central

    Shvedova, Anna A.; Yanamala, Naveena; Kisin, Elena R.; Khailullin, Timur O.; Birch, M. Eileen; Fatkhutdinova, Liliya M.

    2016-01-01

    Background As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans. Methods In the present study, global mRNA and ncRNA expression profiles in the blood of exposed workers, having direct contact with MWCNT aerosol for at least 6 months (n = 8), were compared with expression profiles of non-exposed (n = 7) workers (e.g., professional and/or technical staff) from the same manufacturing facility. Results Significant changes in the ncRNA and mRNA expression profiles were observed between exposed and non-exposed worker groups. An integrative analysis of ncRNA-mRNA correlations was performed to identify target genes, functional relationships, and regulatory networks in MWCNT-exposed workers. The coordinated changes in ncRNA and mRNA expression profiles revealed a set of miRNAs and their target genes with roles in cell cycle regulation/progression/control, apoptosis and proliferation. Further, the identified pathways and signaling networks also revealed MWCNT potential to trigger pulmonary and cardiovascular effects as well as carcinogenic outcomes in humans, similar to those previously described in rodents exposed to MWCNTs. Conclusion This study is the first to investigate aberrant changes in mRNA and ncRNA expression profiles in the blood of humans exposed to MWCNT. The significant changes in several miRNAs and mRNAs expression as well as their regulatory networks are important for getting molecular insights into the MWCNT-induced toxicity and pathogenesis in humans. Further large-scale prospective studies are necessary to validate the potential applicability of such changes in mRNAs and mi

  14. PREFACE: NC-AFM 2006: Proceedings of the 9th International Conference on Non-contact Atomic Force Microscopy

    NASA Astrophysics Data System (ADS)

    Tomitori, Masahiko; Onishi, Hiroshi

    2007-02-01

    The advent of scanning probe microscopy (SPM) in the 1980s has significantly promoted nanoscience and nanotechnology. In particular, non-contact atomic force microscopy (NC-AFM), one of the SPM family, has unique capabilities with high spatial resolution for nanoscale measurements in vacuum, air and liquids. In the last decade we have witnessed the rapid progress of NC-AFM with improved performance and increasing applications. A series of NC-AFM international conferences have greatly contributed to this field. Initiated in Osaka in 1998, the NC-AFM meeting has been followed by annual conferences at Pontresina, Hamburg, Kyoto, Montreal, Dingle, Seattle and Bad Essen. The 9th conference was held in Kobe, Japan, 16-20 July 2006. This special issue of Nanotechnology contains the outstanding contributions of the conference. During the meeting delegates learnt about a number of significant advances. Topics covered atomic resolution imaging of metals, semiconductors, insulators, ionic crystals, oxides, molecular systems, imaging of biological materials in various environments and novel instrumentation. Work also included the characterization of electronic and magnetic properties, tip and cantilever fabrication and characterization, atomic distinction based on analysis of tip-sample interaction, atomic scale manipulation, fabrication of nanostructures using NC-AFM, and related theories and simulations. We are greatly impressed by the increasing number of applications, and convinced that NC-AFM and related techniques are building a bridge to a future nano world, where quantum phenomena will dominate and nano devices will be realized. In addition, a special session on SPM road maps was held as a first trial in the field, where the future prospects of SPM were discussed enthusiastically. The overall success of the NC-AFM 2006 conference was due to the efforts of many individuals and groups with respect to scientific and technological progress, as well as the international

  15. Dipole polarizabilities of trimetallic nitride endohedral fullerenes M 3N@C 2n (M = Sc and Y; 2 n = 68-98)

    NASA Astrophysics Data System (ADS)

    He, Jiangang; Wu, Kechen; Sa, Rongjian; Li, Qiaohong; Wei, Yongqin

    2009-06-01

    The electronic structures and static dipole polarizabilities of M 3N@C 2n fullerenes (M = Sc and Y; 2 n = 68-98) were studied by using density functional theory. Unlike nonmetal endohedral fullerenes, M 3N@C 2n show smaller static dipole polarizabilities than the corresponding C 2n ones do. It is because the induced electric field of carbon cages is reduced by inserting M 3N cluster. The mean dipole polarizabilities of M 3N@C 2n fullerenes were found to correlate closely to their chemical hardness and electron delocalization volume. The refractive indexes of the face-centered-cubic crystals assembled by M 3N@C 2n fullerenes were also estimated.

  16. 40 CFR 721.10175 - 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd. acyl) derivs., inner salts. 721.10175 Section 721... 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd....

  17. 40 CFR 721.10175 - 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd. acyl) derivs., inner salts. 721.10175 Section 721... 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18 and C18-unsatd....

  18. Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.

    PubMed

    Kunkeaw, N; Jeon, S H; Lee, K; Johnson, B H; Tanasanvimon, S; Javle, M; Pairojkul, C; Chamgramol, Y; Wongfieng, W; Gong, B; Leelayuwat, C; Lee, Y S

    2013-08-08

    We have recently identified nc886 (pre-miR-886 or vtRNA2-1) as a novel type of non-coding RNA that inhibits activation of protein kinase R (PKR). PKR's pro-apoptotic role through eukaryotic initiation factor 2 α (eIF2α) phosphorylation is well established in the host defense against viral infection. Paradoxically, some cancer patients have elevated PKR activity; however, its cause and consequence are not understood. Initially, we evaluated the expression of nc886, PKR and eIF2α in non-malignant cholangiocyte and cholangiocarcinoma (CCA) cells. nc886 is repressed in CCA cells and this repression is the cause of PKR's activation therein. nc886 alone is necessary and sufficient for suppression of PKR via direct physical interaction. Consistently, artificial suppression of nc886 in cholangiocyte cells activates the canonical PKR/eIF2α cell death pathway, suggesting a potential significance of the nc886 suppression and the consequent PKR activation in eliminating pre-malignant cells during tumorigenesis. In comparison, active PKR in CCA cells does not induce phospho-eIF2α nor apoptosis, but promotes the pro-survival nuclear factor-κB pathway. Thus, PKR has a dual life or death role during tumorigenesis. Similarly to the CCA cell lines, nc886 tends to be decreased but PKR tends to be activated in our clinical samples from CCA patients. Collectively from our data, we propose a tumor surveillance model for nc886's role in the PKR pathway during tumorigenesis.

  19. The many faces of agency

    NASA Astrophysics Data System (ADS)

    Doyle, Walter

    2015-06-01

    This forum article is a response to the article by Alandeom W. Oliveira, Patterson Rogers, Cassie F. Quigley, Denis Sambursky, Kimberly Barss, and Seema Rivera, The article explores agency from the perspective of both personal action and an understanding of causality within environmental systems, and it explores environmental read-alouds as pedagogical events to enhance elementary school students' climate literacy and activism. In my response I attempt to sharpen the idea of agency through the literatures on (1) prevention education and (2) the dynamics of classroom task systems.

  20. Awe, uncertainty, and agency detection.

    PubMed

    Valdesolo, Piercarlo; Graham, Jesse

    2014-01-01

    Across five studies, we found that awe increases both supernatural belief (Studies 1, 2, and 5) and intentional-pattern perception (Studies 3 and 4)-two phenomena that have been linked to agency detection, or the tendency to interpret events as the consequence of intentional and purpose-driven agents. Effects were both directly and conceptually replicated, and mediational analyses revealed that these effects were driven by the influence of awe on tolerance for uncertainty. Experiences of awe decreased tolerance for uncertainty, which, in turn, increased the tendency to believe in nonhuman agents and to perceive human agency in random events.