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Sample records for aggregate capital requirements

  1. 12 CFR 240.8 - Capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (12 CFR 208.43). (b) Capital required for an uninsured state-licensed branch of a foreign bank. A... Y (12 CFR 225.2(r)(3)). (c) Capital required for financial holding companies and bank holding... transactions must be well-capitalized as defined in § 225.2(r) of Regulation Y (12 CFR 225.2(r)). (d)...

  2. Taking Capital Requirements into Account.

    ERIC Educational Resources Information Center

    Jenny, Hans; And Others

    1982-01-01

    A comprehensive capital charge policy is recommended as an integral part of college budgeting and reporting. It includes three components: a capital renewal and replacement charge, a new equipment and library and laboratory acquisitions budget, and a debt repayment schedule using internal borrowing. (MSE)

  3. 12 CFR 325.3 - Minimum leverage capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Minimum leverage capital requirement. 325.3... GENERAL POLICY CAPITAL MAINTENANCE Minimum Capital Requirements § 325.3 Minimum leverage capital requirement. (a) General. Banks must maintain at least the minimum leverage capital requirement set forth...

  4. 12 CFR 1750.4 - Minimum capital requirement computation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Minimum capital requirement computation. 1750.4... URBAN DEVELOPMENT SAFETY AND SOUNDNESS CAPITAL Minimum Capital § 1750.4 Minimum capital requirement computation. (a) The minimum capital requirement for each Enterprise shall be computed by adding the...

  5. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... capital requirement and market risk capital requirement. (b) Alternative requirements. With the approval... percent but no less than 10 percent of the sum of the Bank's credit risk capital requirement and market... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Operations risk capital requirement....

  6. 12 CFR 615.5240 - Permanent capital requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Permanent capital requirements. 615.5240... capital requirements. (a) The capitalization bylaws shall enable the institution to meet the capital adequacy standards established under subparts H and K of this part and the total capital...

  7. 12 CFR 615.5240 - Permanent capital requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Permanent capital requirements. 615.5240... capital requirements. (a) The capitalization bylaws shall enable the institution to meet the capital adequacy standards established under subparts H and K of this part and the total capital...

  8. 12 CFR 932.4 - Credit risk capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Credit risk capital requirement. 932.4 Section 932.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.4 Credit risk capital requirement. (a) General requirement. Each Bank's credit...

  9. 12 CFR 932.4 - Credit risk capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Credit risk capital requirement. 932.4 Section 932.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.4 Credit risk capital requirement. (a) General requirement. Each Bank's credit...

  10. 12 CFR 932.5 - Market risk capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Market risk capital requirement. 932.5 Section 932.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.5 Market risk capital requirement. (a) General requirement. (1) Each Bank's...

  11. 12 CFR 567.9 - Tangible capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Tangible capital requirement. 567.9 Section 567.9 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.9 Tangible capital requirement. (a) Savings associations shall have...

  12. 12 CFR 567.2 - Minimum regulatory capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Minimum regulatory capital requirement. 567.2 Section 567.2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.2 Minimum regulatory capital requirement. (a) To meet its...

  13. 12 CFR 567.2 - Minimum regulatory capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Minimum regulatory capital requirement. 567.2 Section 567.2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.2 Minimum regulatory capital requirement. (a) To meet its...

  14. 12 CFR 567.9 - Tangible capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Tangible capital requirement. 567.9 Section 567.9 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.9 Tangible capital requirement. (a) Savings associations shall have...

  15. 12 CFR 932.2 - Total capital requirement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Total capital requirement. 932.2 Section 932.2 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.2 Total capital requirement. Each Bank...

  16. 12 CFR 932.3 - Risk-based capital requirement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Risk-based capital requirement. 932.3 Section 932.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.3 Risk-based capital requirement....

  17. 12 CFR 932.3 - Risk-based capital requirement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Risk-based capital requirement. 932.3 Section 932.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.3 Risk-based capital requirement....

  18. 12 CFR 932.2 - Total capital requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Total capital requirement. 932.2 Section 932.2 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.2 Total capital requirement. Each Bank...

  19. 12 CFR 932.3 - Risk-based capital requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Risk-based capital requirement. 932.3 Section 932.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.3 Risk-based capital requirement....

  20. 12 CFR 932.2 - Total capital requirement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Total capital requirement. 932.2 Section 932.2 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.2 Total capital requirement. Each Bank...

  1. 12 CFR 932.3 - Risk-based capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Risk-based capital requirement. 932.3 Section 932.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.3 Risk-based capital requirement....

  2. 12 CFR 932.2 - Total capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Total capital requirement. 932.2 Section 932.2 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.2 Total capital requirement. (a) Each Bank...

  3. 12 CFR 932.3 - Risk-based capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Risk-based capital requirement. 932.3 Section 932.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.3 Risk-based capital requirement....

  4. 12 CFR 567.3 - Individual minimum capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Individual minimum capital requirements. 567.3 Section 567.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.3 Individual minimum capital requirements. (a) Purpose and scope....

  5. 12 CFR 567.3 - Individual minimum capital requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Individual minimum capital requirements. 567.3 Section 567.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.3 Individual minimum capital requirements. (a) Purpose and scope....

  6. 12 CFR 567.3 - Individual minimum capital requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Individual minimum capital requirements. 567.3 Section 567.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.3 Individual minimum capital requirements. (a) Purpose and scope....

  7. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  8. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  9. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  10. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  11. 12 CFR 3.10 - Minimum capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... individual assessment of numerous factors, including those listed at this section (national banks), 12 CFR... Capital Ratio Requirements and Buffers § 3.10 Minimum capital requirements. (a) Minimum...

  12. 12 CFR 652.95 - Failure to meet capital requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Failure to meet capital requirements. 652.95... MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.95 Failure to meet capital requirements. (a) Determination and notice. At any time, we may determine that you are not...

  13. 12 CFR 217.10 - Minimum capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Minimum capital requirements. 217.10 Section 217.10 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM CAPITAL ADEQUACY OF BOARD-REGULATED INSTITUTIONS Capital Ratio Requirements and Buffers § 217.10...

  14. 12 CFR 932.2 - Total capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Total capital requirement. 932.2 Section 932.2 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... total assets. For purposes of determining the leverage ratio, total capital shall be computed...

  15. 12 CFR 349.8 - Capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... institution offering or entering into retail forex transactions must be well capitalized as defined by 12 CFR part 325 or 12 CFR part 324, as applicable, unless specifically exempted by the FDIC in writing....

  16. Applying Statement 34's Capital Asset Requirements.

    ERIC Educational Resources Information Center

    Finden, Randal

    2001-01-01

    Discusses common issues and offers recommendations related to revisions in Governmental Accounting Standards Board Statement 34 wherein the financial reporting of the general fixed-assets account group is eliminated and instead a school district's general capital assets are reported and depreciated on the new statement of net assets and statement…

  17. 40 CFR 35.3135 - Specific capitalization grant agreement requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Specific capitalization grant agreement requirements. 35.3135 Section 35.3135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3135 Specific capitalization...

  18. 17 CFR 240.15c3-1c - Consolidated computations of net capital and aggregate indebtedness for certain subsidiaries and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... net capital and aggregate indebtedness for certain subsidiaries and affiliates (Appendix C to 17 CFR... (Appendix C to 17 CFR 240.15c3-1). (a) Flow Through Capital Benefits. Every broker or dealer in computing its net capital and aggregate indebtedness pursuant to 17 CFR 240.15c3-1 shall, subject to...

  19. 40 CFR 35.3550 - Specific capitalization grant agreement requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Drinking Water State Revolving Funds § 35.3550 Specific capitalization grant agreement requirements. (a) General. A State must agree to comply with this subpart, the general grant regulations at 40 CFR part 31, and specific conditions of the grant. A...

  20. 13 CFR 120.472 - Higher individual minimum capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... directors and senior management; and (f) Other risk-related factors, as determined by SBA. ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Higher individual minimum capital requirement. 120.472 Section 120.472 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION...

  1. 12 CFR 932.4 - Credit risk capital requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Credit risk capital requirement. 932.4 Section 932.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND... opinion that represents, with a high degree of certainty, that in the event of a legal...

  2. 12 CFR 211.12 - Lending limits and capital requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... banks, as described in 12 CFR 250.165. (b) Loans and extensions of credit to one person—(1) Loans and... 12 Banks and Banking 2 2013-01-01 2013-01-01 false Lending limits and capital requirements. 211.12 Section 211.12 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE...

  3. 40 CFR 35.3550 - Specific capitalization grant agreement requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... subpart, the general grant regulations at 40 CFR part 31, and specific conditions of the grant. A State... match requirements associated with subsequent capitalization grants. (h) Provide match for State program... with all applicable Federal cross-cutting authorities. (p) Comply with provisions to avoid...

  4. 7 CFR 4290.210 - Minimum capital requirements for RBICs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Minimum capital requirements for RBICs. 4290.210 Section 4290.210 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT...

  5. Capital Requirements Estimating Model (CREMOD) for electric utilities. Volume I. Methodology description, model, description, and guide to model applications. [For each year up to 1990

    SciTech Connect

    Collins, D E; Gammon, J; Shaw, M L

    1980-01-01

    The Capital Requirements Estimating Model for the Electric Utilities (CREMOD) is a system of programs and data files used to estimate the capital requirements of the electric utility industry for each year between the current one and 1990. CREMOD disaggregates new electric plant capacity levels from the Mid-term Energy Forecasting System (MEFS) Integrating Model solution over time using actual projected commissioning dates. It computes the effect on aggregate capital requirements of dispersal of new plant and capital expenditures over relatively long construction lead times on aggregate capital requirements for each year. Finally, it incorporates the effects of real escalation in the electric utility construction industry on these requirements and computes the necessary transmission and distribution expenditures. This model was used in estimating the capital requirements of the electric utility sector. These results were used in compilation of the aggregate capital requirements for the financing of energy development as published in the 1978 Annual Report to Congress. This volume, Vol. I, explains CREMOD's methodology, functions, and applications.

  6. 13 CFR 120.473 - Procedures for determining individual minimum capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... acceptable plan to reach the individual minimum capital requirement by the date required. (f) Change in... affecting the SBLC's capital adequacy or its ability to reach the required individual minimum...

  7. 13 CFR 107.210 - Minimum capital requirements for Licensees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Capitalizing An Sbic § 107.210 Minimum capital... reasonably projecting profitable operations; and (iii) Has a reasonable timetable for achieving...

  8. 13 CFR 107.210 - Minimum capital requirements for Licensees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Capitalizing An Sbic § 107.210 Minimum capital... reasonably projecting profitable operations; and (iii) Has a reasonable timetable for achieving...

  9. 12 CFR 324.10 - Minimum capital requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... association shall determine its tangible capital ratio in accordance with 12 CFR 390.468. (ii) As of January 1... association shall determine its tangible capital ratio in accordance with 12 CFR 390.468. (ii) As of January 1... assets shall have the meaning provided in 12 CFR 324.401(g). (d) Capital adequacy. (1)...

  10. 78 FR 42796 - 30-Day Notice of Proposed Information Collection: Submission Requirements for the Capital Advance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... Capital Advance Program Section 202/811 AGENCY: Office of the Chief Information Officer, HUD. ACTION... Information Collection: Submission Requirements for the Capital Advance Program Section 202/811. OMB Approval... Sections 202 and 811 capital advance projects that have not yet been finally closed. The...

  11. 13 CFR 108.210 - Minimum capital requirements for NMVC Companies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NMVC Companies. 108.210 Section 108.210 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Company § 108.210 Minimum capital requirements for NMVC Companies. You must have Regulatory Capital of at least $5,000,000 and Leverageable Capital of at least $500,000 to become a NMVC Company....

  12. 12 CFR 217.142 - Risk-based capital requirement for securitization exposures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... loan holding company is well capitalized, as defined in 12 CFR 225.2. For purposes of determining... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Risk-based capital requirement for... THE FEDERAL RESERVE SYSTEM CAPITAL ADEQUACY OF BOARD-REGULATED INSTITUTIONS Risk-Weighted...

  13. 7 CFR 4290.210 - Minimum capital requirements for RBICs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY... Leverageable Capital of at least $500,000, to become a RBIC. (b) Exception. (1) The Secretary in his or...

  14. 12 CFR 956.4 - Risk-based capital requirement for investments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Risk-based capital requirement for investments... OFF-BALANCE SHEET ITEMS FEDERAL HOME LOAN BANK INVESTMENTS § 956.4 Risk-based capital requirement for... the investments multiplied by: (a) A factor associated with the credit rating of the investments...

  15. 12 CFR 950.11 - Capital stock requirements; unilateral redemption of excess stock.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Capital stock requirements; unilateral redemption of excess stock. 950.11 Section 950.11 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL... Housing Associates § 950.11 Capital stock requirements; unilateral redemption of excess stock. (a)...

  16. 12 CFR 955.6 - Risk-based capital requirement for acquired member assets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Risk-based capital requirement for acquired... ASSETS AND OFF-BALANCE SHEET ITEMS ACQUIRED MEMBER ASSETS § 955.6 Risk-based capital requirement for... losses as support for the credit risk of all AMA estimated by the Bank to represent a credit risk that...

  17. 12 CFR 955.6 - Risk-based capital requirement for acquired member assets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Risk-based capital requirement for acquired... ASSETS AND OFF-BALANCE SHEET ITEMS ACQUIRED MEMBER ASSETS § 955.6 Risk-based capital requirement for... losses as support for the credit risk of all AMA estimated by the Bank to represent a credit risk that...

  18. 12 CFR 955.6 - Risk-based capital requirement for acquired member assets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Risk-based capital requirement for acquired... ASSETS AND OFF-BALANCE SHEET ITEMS ACQUIRED MEMBER ASSETS § 955.6 Risk-based capital requirement for... losses as support for the credit risk of all AMA estimated by the Bank to represent a credit risk that...

  19. 12 CFR 955.6 - Risk-based capital requirement for acquired member assets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Risk-based capital requirement for acquired... ASSETS AND OFF-BALANCE SHEET ITEMS ACQUIRED MEMBER ASSETS § 955.6 Risk-based capital requirement for... losses as support for the credit risk of all AMA estimated by the Bank to represent a credit risk that...

  20. 12 CFR 325.3 - Minimum leverage capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... capital level based on the institution's particular risk profile. Where the FDIC determines that the... adequate, or where a bank has sizable off-balance sheet or funding risks, significant risks from concentrations of credit or nontraditional activities, excessive interest rate risk exposure, or a...

  1. 12 CFR 950.11 - Capital stock requirements; unilateral redemption of excess stock.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Capital stock requirements; unilateral redemption of excess stock. 950.11 Section 950.11 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS ADVANCES Advances to Members § 950.11 Capital...

  2. Use of recycled fine aggregate in concretes with durable requirements.

    PubMed

    Zega, Claudio Javier; Di Maio, Angel Antonio

    2011-11-01

    The use of construction waste materials as aggregates for concrete production is highly attractive compared to the use of non-renewable natural resources, promoting environmental protection and allowing the development of a new raw material. Several countries have recommendations for the use of recycled coarse aggregate in structural concrete, whereas the use of the fine fraction is limited because it may produce significant changes in some properties of concrete. However, during the last decade the use of recycled fine aggregates (RFA) has achieved a great international interest, mainly because of economic implications related to the shortage of natural sands suitable for the production of concrete, besides to allow an integral use of this type of waste. In this study, the durable behaviour of structural concretes made with different percentage of RFA (0%, 20%, and 30%) is evaluated. Different properties related to the durability of concretes such as absorption, sorptivity, water penetration under pressure, and carbonation are determined. In addition, the results of compressive strength, static modulus of elasticity and drying shrinkage are presented. The obtained results indicate that the recycled concretes have a suitable resistant and durable behaviour, according to the limits indicated by different international codes for structural concrete. PMID:21775123

  3. 12 CFR 955.6 - Risk-based capital requirement for acquired member assets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Risk-based capital requirement for acquired member assets. 955.6 Section 955.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS ACQUIRED MEMBER ASSETS § 955.6 Risk-based capital requirement for acquired member assets. (a) General. Each...

  4. A delicate balance between functionally required flexibility and aggregation risk in a β-rich protein

    PubMed Central

    Ferrolino, Mylene C.; Zhuravleva, Anastasia; Budyak, Ivan L.; Krishnan, Beena; Gierasch, Lila M.

    2014-01-01

    Susceptibility to aggregation is general to proteins because of the potential for intermolecular interactions between hydrophobic stretches in their amino acid sequences. Protein aggregation has been implicated in several catastrophic diseases, yet we still lack in-depth understanding about how proteins are channeled to this state. Using a predominantly β-sheet protein whose folding has been explored in detail: cellular retinoic acid-binding protein 1 (CRABP1), as a model, we have tackled the challenge of understanding the links between a protein’s natural tendency to fold, ‘breathe’, and function with its propensity to misfold and aggregate. We identified near-native dynamic species that lead to aggregation and found that inherent structural fluctuations in the native protein, resulting in opening of the ligand entry portal, expose hydrophobic residues on the most vulnerable aggregation-prone sequences in CRABP1. CRABP1 and related intracellullar lipid-binding proteins have not been reported to aggregate inside cells, and we speculate that the cellular concentration of their open, aggregation-prone conformations is sufficient for ligand binding but below the critical concentration for aggregation. Our finding provides an example of how nature fine-tunes a delicate balance between protein function, conformational variability, and aggregation vulnerability, and implies that with the evolutionary requirement for proteins to fold and function, aggregation becomes an unavoidable but controllable risk. PMID:24236614

  5. Long-range hospital capital requirements planning: the state of the art, a proposal for change.

    PubMed

    Hogan, A J

    1984-01-01

    A Hospital Capital Requirements Planning System is proposed to channel competition through the use of a regional planning model. This model would help to reduce the social deadweight loss arising from competition-induced uncertainty. The system would increase the internal long-range planning capacity of hospitals and improve the quality of the applications presented for Certificate of Need review. Both health systems planners and investment bankers should have better information with which to evaluate hospital capital investment proposals. PMID:10269910

  6. On meeting capital requirements with a chance-constrained optimization model.

    PubMed

    Atta Mills, Ebenezer Fiifi Emire; Yu, Bo; Gu, Lanlan

    2016-01-01

    This paper deals with a capital to risk asset ratio chance-constrained optimization model in the presence of loans, treasury bill, fixed assets and non-interest earning assets. To model the dynamics of loans, we introduce a modified CreditMetrics approach. This leads to development of a deterministic convex counterpart of capital to risk asset ratio chance constraint. We pursue the scope of analyzing our model under the worst-case scenario i.e. loan default. The theoretical model is analyzed by applying numerical procedures, in order to administer valuable insights from a financial outlook. Our results suggest that, our capital to risk asset ratio chance-constrained optimization model guarantees banks of meeting capital requirements of Basel III with a likelihood of 95 % irrespective of changes in future market value of assets. PMID:27186464

  7. 13 CFR 120.462 - What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... until differences between the two calculations are resolved. (e) Capital restoration plan. (1) Filing requirement. An SBA Supervised Lender must file a written capital restoration plan with SBA within 45 days of... Supervised Lender charged with carrying out the capital restoration plan. (3) SBA response. SBA will...

  8. 13 CFR 120.462 - What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... until differences between the two calculations are resolved. (e) Capital restoration plan. (1) Filing requirement. An SBA Supervised Lender must file a written capital restoration plan with SBA within 45 days of... Supervised Lender charged with carrying out the capital restoration plan. (3) SBA response. SBA will...

  9. 13 CFR 120.462 - What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... until differences between the two calculations are resolved. (e) Capital restoration plan. (1) Filing requirement. An SBA Supervised Lender must file a written capital restoration plan with SBA within 45 days of... Supervised Lender charged with carrying out the capital restoration plan. (3) SBA response. SBA will...

  10. 13 CFR 120.462 - What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... until differences between the two calculations are resolved. (e) Capital restoration plan. (1) Filing requirement. An SBA Supervised Lender must file a written capital restoration plan with SBA within 45 days of... Supervised Lender charged with carrying out the capital restoration plan. (3) SBA response. SBA will...

  11. 17 CFR 402.2 - Capital requirements for registered government securities brokers and dealers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Capital requirements for registered government securities brokers and dealers. 402.2 Section 402.2 Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2...

  12. 17 CFR 240.15c3-1 - Net capital requirements for brokers or dealers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Net capital requirements for brokers or dealers. 240.15c3-1 Section 240.15c3-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and Regulations Under the Securities Exchange...

  13. 77 FR 60057 - Margin and Capital Requirements for Covered Swap Entities; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ..., 2011 (76 FR 27564) to establish minimum margin and capital requirements for uncleared swaps and... international basis could help address those issues. \\3\\ See 76 FR 27564 (May 11, 2011). \\4\\ See 76 FR 37029... on its proposed margin rule under section 731 and 764 of the Dodd-Frank Act. See 76 FR 41109 (July...

  14. An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid.

    PubMed

    Waters, Christopher M; Hirt, Helmut; McCormick, John K; Schlievert, Patrick M; Wells, Carol L; Dunny, G M

    2004-05-01

    Aggregation substance (AS), a plasmid-encoded surface protein of Enterococcus faecalis, plays important roles in virulence and antibiotic resistance transfer. Previous studies have suggested that AS-mediated aggregation of enterococcal cells could involve the binding of this protein to cell wall lipoteichoic acid (LTA). Here, a method to purify an undegraded form of Asc10, the AS of the plasmid pCF10, is described. Using this purified protein, direct binding of Asc10 to purified E. faecalis LTA was demonstrated. Equivalent binding of Asc10 to LTA purified from INY3000, an E. faecalis strain that is incapable of aggregation, was also observed. Surprisingly, mutations in a previously identified aggregation domain from amino acids 473 to 683 that abolished aggregation had no effect on LTA binding. In frame deletion analysis of Asc10 was used to identify a second aggregation domain located in the N-terminus of the protein from amino acids 156 to 358. A purified Asc10 mutant protein lacking this domain showed reduced LTA binding, while a purified N-terminal fragment from amino acids 44-331 had high LTA binding. Like the previously described aggregation domain, the newly identified Asc10((156-358)) aggregation domain was also required for efficient internalization of E. faecalis into HT-29 enterocytes. Thus, Asc10 possess two distinct domains required for aggregation and eukaryotic cell internalization: an N-terminal domain that promotes binding to LTA and a second domain located near the middle of the protein. PMID:15130132

  15. Assessment of capital requirements for alternative fuels infrastructure under the PNGV program

    SciTech Connect

    Stork, K.; Singh, M.; Wang, M.; Vyas, A.

    1998-12-31

    This paper presents an assessment of the capital requirements of using six different fuels in the vehicles with tripled fuel economy (3X vehicles) that the Partnership for a new Generation of Vehicles is currently investigating. The six fuels include two petroleum-based fuels (reformulated gasoline and low-sulfur diesel) and four alternative fuels (methanol, ethanol, dimethyl ether, and hydrogen). This study develops estimates of cumulative capital needs for establishing fuels production and distribution infrastructure to accommodate 3X vehicle fuel needs. Two levels of fuel volume-70,000 barrels per day and 1.6 million barrels per day-were established for meeting 3X-vehicle fuel demand. As expected, infrastructure capital needs for the high fuel demand level are much higher than for the low fuel demand level. Between fuel production infrastructure and distribution infrastructure, capital needs for the former far exceed those for the latter. Among the four alternative fuels, hydrogen bears the largest capital needs for production and distribution infrastructure.

  16. 77 FR 71369 - Capital, Margin, and Segregation Requirements for Security-Based Swap Dealers and Major Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION 17 CFR Part 240 RIN 3235-AL12 Capital, Margin, and Segregation Requirements for Security-Based Swap Dealers and Major Security-Based Swap Participants and Capital Requirements for Broker-Dealers Correction In proposed rule document...

  17. 75 FR 76705 - Joint Public Roundtable on Issues Related to Capital and Margin Requirements for Swaps and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint Public Roundtable on Issues Related to Capital and Margin... Protection Act (the ``Act'') that require the Agencies ] to adopt rules for the capital and margin... published at http://www.cftc.gov/LawRegulation/DoddFrankAct/OTC_5_CapMargin.html . The roundtable...

  18. Capital requirements for the transportation of energy materials: 1979 arc estimates

    SciTech Connect

    Not Available

    1980-08-29

    Summaries of transportation investment requirements through 1990 are given for the low, medium and high scenarios. Total investment requirements for the three modes and the three energy commodities can accumulate to a $46.3 to $47.0 billion range depending on the scenario. The high price of oil, following the evidence of the last year, is projected to hold demand for oil below the recent past. Despite the overall decrease in traffic some investment in crude oil and LPG pipelines is necessary to reach new sources of supply. Although natural gas production and consumption is projected to decline through 1990, new investments in carrying capacity also are required due to locational shifts in supply. The Alaska Natural Gas Transportation System is the dominant investment for energy transportation in the next ten years. This year's report focuses attention on waterborne coal transportation to the northeast states in keeping with a return to significant coal consumption projected for this area. A resumption of such shipments will require a completely new fleet. The investment estimates given in this report identify capital required to transport projected energy supplies to market. The requirement is strategic in the sense that other reasonable alternatives do not exist or that a shared load of new growth can be expected. Not analyzed or forecasted are investments in transportation facilities made in response to local conditions. The total investment figures, therefore, represent a minimum necessary capital improvement to respond to changes in interregional supply conditions.

  19. 13 CFR 108.1830 - NMVC Company's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM NMVC Company's Noncompliance With Terms of Leverage Computation of Nmvc Company's Capital Impairment § 108.1830 NMVC Company's Capital Impairment definition and... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false NMVC Company's Capital...

  20. 7 CFR 4290.1830 - RBIC's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INVESTMENT COMPANY (âRBICâ) PROGRAM RBIC's Noncompliance With Terms of Leverage Computation of Rbic's Capital... to determine RBIC's Capital Impairment condition. The Secretary may make his or her own...

  1. 7 CFR 4290.1830 - RBIC's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INVESTMENT COMPANY (âRBICâ) PROGRAM RBIC's Noncompliance With Terms of Leverage Computation of Rbic's Capital... to determine RBIC's Capital Impairment condition. The Secretary may make his or her own...

  2. 7 CFR 4290.1830 - RBIC's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INVESTMENT COMPANY (âRBICâ) PROGRAM RBIC's Noncompliance With Terms of Leverage Computation of Rbic's Capital... to determine RBIC's Capital Impairment condition. The Secretary may make his or her own...

  3. 7 CFR 4290.1830 - RBIC's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INVESTMENT COMPANY (âRBICâ) PROGRAM RBIC's Noncompliance With Terms of Leverage Computation of Rbic's Capital... to determine RBIC's Capital Impairment condition. The Secretary may make his or her own...

  4. 7 CFR 4290.1830 - RBIC's Capital Impairment definition and general requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INVESTMENT COMPANY (âRBICâ) PROGRAM RBIC's Noncompliance With Terms of Leverage Computation of Rbic's Capital... to determine RBIC's Capital Impairment condition. The Secretary may make his or her own...

  5. Comparative economics for DUCRETE spent fuel storage cask handling, transportation, and capital requirements

    SciTech Connect

    Powell, F.P.

    1995-04-01

    This report summarizes economic differences between a DUCRETE spent nuclear fuel storage cask and a conventional concrete storage cask in the areas of handling, transportation, and capital requirements. The DUCRETE cask is under evaluation as a new technology that could substantially reduce the overall costs of spent fuel and depleted U disposal. DUCRETE incorporates depleted U in a Portland cement mixture and functions as the cask`s primary radiation barrier. The cask system design includes insertion of the US DOE Multi-Purpose Canister inside the DUCRETE cask. The economic comparison is from the time a cask is loaded in a spent fuel pool until it is placed in the repository and includes the utility and overall US system perspectives.

  6. Capital requirements for the transportation of energy materials: 1979 ARC estimates. Draft final report

    SciTech Connect

    Not Available

    1980-08-13

    This report contains TERA's estimates of capital requirements to transport natural gas, crude oil, petroleum products, and coal in the United States by 1990. The low, medium, and high world-oil-price scenarios from the EIA's Mid-range Energy Forecasting System (MEFS), as used in the 1979 Annual Report to Congress (ARC), were provided as a basis for the analysis and represent three alternative futures. TERA's approach varies by energy commodity to make best use of the information and analytical tools available. Summaries of transportation investment requirements through 1990 are given. Total investment requirements for three modes (pipelines, rails, waterways and the three energy commodities can accumulate to a $49.9 to $50.9 billion range depending on the scenario. The scenarios are distinguished primarily by the world price of oil which, given deregulation of domestic oil prices, affects US oil prices even more profoundly than in the past. The high price of oil, following the evidence of the last year, is projected to hold demand for oil below the recent past.

  7. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  8. 12 CFR Appendix C to Part 167 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 167, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  9. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  10. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  11. 12 CFR Appendix C to Part 167 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 167, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  12. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR part 225, appendix G, to calculate its risk-based capital requirements. (2) Any savings... Exposure Report); (iii) Is a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to...

  13. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part 225, appendix G, to calculate its...

  14. Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding

    PubMed Central

    Bateman, David A; McLaurin, JoAnne; Chakrabartty, Avijit

    2007-01-01

    Background Aggregation of the amyloid peptides, Aβ40 and Aβ42, is known to be involved in the pathology of Alzheimer's disease (AD). Here we investigate the relationship between peptide aggregation and cell surface binding of three forms of Aβ (Aβ40, Aβ42, and an Aβ mutant). Results Using confocal microscopy and flow cytometry with fluorescently labelled Aβ, we demonstrate a correlation between the aggregation propensity of the Alzheimer amyloid peptides and their neuronal cell surface association. We find that the highly aggregation prone Aβ42 associates with the surface of neuronal cells within one hour, while the less aggregation prone Aβ40 associates over 24 hours. We show that a double mutation in Aβ42 that reduces its aggregation propensity also reduces its association with the cell surface. Furthermore, we find that a cell line that is resistant to Aβ cytotoxicity, the non-neuronal human lymphoma cell line U937, does not bind either Aβ40 or Aβ42. Conclusion Taken together, our findings reveal that amyloid peptide aggregation propensity is an essential determinant of neuronal cell surface association. We anticipate that our approach, involving Aβ imaging in live cells, will be highly useful for evaluating the efficacy of therapeutic drugs that prevent toxic Aβ association with neuronal cells. PMID:17475015

  15. CAPITAL REQUIREMENTS AND BUSBAR COSTS FOR POWER IN THE OHIO RIVER BASIN, 1985 AND 2000

    EPA Science Inventory

    This report was prepared as part of the Ohio River Basin Energy Study (ORBES), a multidisciplinary policy research program supported by the Environmental Protection Agency. It provides estimates of capital-output ratios and typical operating costs for the comparison of alternativ...

  16. Ecological Footprints and Appropriated Carrying Capacity: Measuring the Natural Capital Requirements of the Human Economy.

    ERIC Educational Resources Information Center

    Ress, William E.; Wackernagel, Mathis

    1996-01-01

    Contrasts conventional economic rationality with economic principles. Develops an empirical approach based on a reinterpretation of carrying capacity that can account for technological advances and trade. Discusses the necessity of diverting much of the present consumption to investment in the maintenance of natural capital stocks. (AIM)

  17. Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3

    PubMed Central

    Nyakundi, David O.; Vuko, Loyiso A. M.; Bentley, Stephen J.; Hoppe, Heinrich; Blatch, Gregory L.; Boshoff, Aileen

    2016-01-01

    The majority of mitochondrial proteins are encoded in the nucleus and need to be imported from the cytosol into the mitochondria, and molecular chaperones play a key role in the efficient translocation and proper folding of these proteins in the matrix. One such molecular chaperone is the eukaryotic mitochondrial heat shock protein 70 (Hsp70); however, it is prone to self-aggregation and requires the presence of an essential zinc-finger protein, Hsp70-escort protein 1 (Hep1), to maintain its structure and function. PfHsp70-3, the only Hsp70 predicted to localize in the mitochondria of P. falciparum, may also rely on a Hep1 orthologue to prevent self-aggregation. In this study, we identified a putative Hep1 orthologue in P. falciparum and co-expression of PfHsp70-3 and PfHep1 enhanced the solubility of PfHsp70-3. PfHep1 suppressed the thermally induced aggregation of PfHsp70-3 but not the aggregation of malate dehydrogenase or citrate synthase, thus showing specificity for PfHsp70-3. Zinc ions were indeed essential for maintaining the function of PfHep1, as EDTA chelation abrogated its abilities to suppress the aggregation of PfHsp70-3. Soluble and functional PfHsp70-3, acquired by co-expression with PfHep-1, will facilitate the biochemical characterisation of this particular Hsp70 protein and its evaluation as a drug target for the treatment of malaria. PMID:27253881

  18. Live imaging of endogenous Ca²⁺/calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity.

    PubMed

    Barcomb, Kelsey; Goodell, Dayton J; Arnold, Don B; Bayer, K Ulrich

    2015-11-01

    The Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) forms 12meric holoenzymes. These holoenzymes cluster into larger aggregates within neurons under ischemic conditions and in vitro when ischemic conditions are mimicked. This aggregation is thought to be mediated by interaction between the regulatory domain of one kinase subunit with the T-site of another kinase subunit in a different holoenzyme, an interaction that requires stimulation by Ca(2+) /CaM and nucleotide for its induction. This model makes several predictions that were verified here: Aggregation in vitro was reduced by the CaMKII inhibitors tatCN21 and tatCN19o (which block the T-site) as well as by KN93 (which is CaM-competitive). Notably, these and previously tested manipulations that block CaMKII activation all reduced aggregation, suggesting an alternative mechanism that instead requires kinase activity. However, experiments with the nucleotide-competitive broad-spectrum kinase inhibitors staurosporin and H7 showed that this is not the case. In vitro, staurosporine and H7 enabled CaMKII aggregation even in the absence of nucleotide. Within rat hippocampal neurons, an intra-body enabled live monitoring of endogenous CaMKII aggregation. This aggregation was blocked by tatCN21, but not by staurosporine, even though both effectively inhibit CaMKII activity. These results support the mechanistic model for CaMKII aggregation and show that kinase activity is not required. CaMKII aggregation is prevented by inhibiting kinase activity with mutations (red italics; shown previously) or inhibitors (red bold; shown here), indicating requirement of kinase activity. However, we show here that nucleotide-competitive inhibitors (green) allow CaMKII aggregation (including endogenous CaMKII within neurons), demonstrating that kinase activity is not required and supporting the current mechanistic model for CaMKII aggregation. PMID:26212614

  19. Capital requirements and busbar costs for power in the Ohio River Basin, 1985 and 2000

    SciTech Connect

    Newcomb, R.; Bancroft, B.

    1981-10-01

    This report was prepared as part of the Ohio River Basin Energy Study (ORBES), a multidisciplinary policy research program supported by the Environmental Protection Agency. It provides estimates of capital-output ratios and typical operating costs for the comparison of alternative energy development scenarios in the ORBES region, which consists of all of Kentucky, most of West Virginia, southwestern Pennsylvania, and substantial portions of Illinois, Indiana and Ohio. Three of the ORBES scenarios are considered: a base case; an expanded export case, with the added facilities fueled by nuclear energy; and a high growth coal forecast.

  20. 24 CFR 905.308 - Federal requirements applicable to all Capital Fund activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... shall comply with the requirements of 24 CFR part 5 (General HUD Program Requirements; Waivers), 24 CFR... Department's generally applicable nondiscrimination and equal opportunity requirements at 24 CFR 5.105(a) and... 24 CFR parts 40 and 41. The PHA shall affirmatively further fair housing in its use of funds...

  1. 76 FR 27801 - Capital Requirements of Swap Dealers and Major Swap Participants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... periods for either proposed rule. \\1\\ See 76 FR 23732 (April 28, 2011). DATES: Comments must be received... activities. See 75 FR 76666 (Dec. 9, 2010). B. Consultation With U.S. Securities and Exchange Commission and...-certified Form 1-FR-FCM financial reports each month. Regulation 1.12 requires FCMs to provide notice of...

  2. Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC.

    PubMed

    Wang, C; Jung, D; Cao, Z; Chung, C Y

    2015-09-25

    The localization of adenylyl cyclase A (ACA) to uropod of cells is required for the stream formation during Dictyostelium development. RacC is a Dictyostelium orthologue of Cdc42. We identified a streaming defect of racC(-) cells as they are clearly less polarized and form smaller and fragmented streams. ACA-YFP is mainly associated with intracellular vesicular structures, but not with the plasma membrane in racC(-) cells. racC(-) cells have a slightly higher number of vesicles than Ax3 cells, suggesting that the defect of ACA trafficking is not simply due to the lack of vesicle formation. While the ACA-YFP vesicles traveled with an average velocity of 9.1 μm/min in Ax3 cells, a slow and diffusional movement without direction with an average velocity of 4 μm/min was maintained in racC(-) cells. Images acquired by using total internal reflection fluorescence (TIRF) microscopy and fluorescence recovery after photobleaching (FRAP) analysis revealed that a significantly decreased number of ACA-YFP vesicles appeared near the cell membrane, indicating a defect in ACA-YFP vesicle trafficking. These results suggest an important role of RacC in the rapid and directional movements of ACA vesicles on microtubules to the plasma membrane, especially to the back of polarized cell. PMID:26315268

  3. 12 CFR Appendix A to Subpart Z of... - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR subpart Z of part 390, appendix A, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part...

  4. 12 CFR Appendix A to Subpart Z of... - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR subpart Z of part 390, appendix A, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part...

  5. 12 CFR Appendix A to Subpart Z of... - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR subpart Z of part 390, appendix A, to calculate its risk-based capital requirements; or (iv) Is a subsidiary of a bank holding company that uses 12 CFR part...

  6. Low capital methods of meeting regulatory requirements for dust control while extending the life of existing equipment in coal burning plants

    SciTech Connect

    Zinkan, K.J.

    1998-07-01

    In order to control dust when using Powder River Basin or dusty coal, you need to start with a plant audit to identify problem areas. Little, if any, capital costs are required in most plants using mechanical and chemical control methods. Safety and health issues need to be addressed at the time a plan is developed. This can lower or eliminate fire potential due to fugitive dust. Also, reduced spray water usage should be included as a goal of any dust control plan. Using this approach, power deregulation does not have to mean higher capital and operating costs.

  7. Intellectual Capital.

    ERIC Educational Resources Information Center

    Snyder, Herbert W.; Pierce, Jennifer Burek

    2002-01-01

    This review focuses on intellectual capital and its relationship to information professionals. Discusses asset recognition; national practices and the acceptance of intellectual capital; definitions of intellectual capital; measuring intellectual capital, including multiple and single variable measures; managing intellectual capital; and knowledge…

  8. Measuring Social Capital Accumulation in Rural Development

    ERIC Educational Resources Information Center

    Teilmann, Kasper

    2012-01-01

    Using a theoretical framework, the study proposes an index that can measure the social capital of local action group (LAG) projects. The index is founded on four indicators: number of ties, bridging social capital, recognition, and diversity, which are aggregated into one social capital index. The index has been tested in LAG-Djursland, Denmark,…

  9. Capital investment requirements for greenhouse gas emissions mitigation in power generation on near term to century time scales and global to regional spatial scales

    SciTech Connect

    Chaturvedi, Vaibhav; Clarke, Leon E.; Edmonds, James A.; Calvin, Katherine V.; Kyle, G. Page

    2014-11-01

    Electrification plays a crucial role in cost-effective greenhouse gas emissions mitigation strategies. Such strategies in turn carry implications for financial capital markets. This paper explores the implication of climate mitigation policy for capital investment demands by the electric power sector on decade to century time scales. We go further to explore the implications of technology performance and the stringency of climate policy for capital investment demands by the power sector. Finally, we discuss the regional distribution of investment demands. We find that stabilizing GHG emissions will require additional investment in the electricity generation sector over and above investments that would be need in the absence of climate policy, in the range of 16 to 29 Trillion US$ (60-110%) depending on the stringency of climate policy during the period 2015 to 2095 under default technology assumptions. This increase reflects the higher capital intensity of power systems that control emissions. Limits on the penetration of nuclear and carbon capture and storage technology could increase costs substantially. Energy efficiency improvements can reduce the investment requirement by 8 to21 Trillion US$ (default technology assumptions), depending on climate policy scenario with higher savings being obtained under the most stringent climate policy. The heaviest investments in power generation were observed in the China, India, SE Asia and Africa regions with the latter three regions dominating in the second half of the 21st century.

  10. 12 CFR 567.4 - Capital directives.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Capital directives. 567.4 Section 567.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.4 Capital directives. (a) Issuance of a Capital Directive—(1) Purpose. In addition to...

  11. 12 CFR 567.4 - Capital directives.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Capital directives. 567.4 Section 567.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.4 Capital directives. (a) Issuance of a Capital Directive—(1) Purpose. In addition to...

  12. 26 CFR 1.1211-1 - Limitation on capital losses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Limitation on capital losses. 1.1211-1 Section... TAX (CONTINUED) INCOME TAXES (CONTINUED) Treatment of Capital Losses § 1.1211-1 Limitation on capital... exchanges of capital assets, plus (ii) The aggregate of all losses sustained in other taxable years...

  13. Allergy Capitals

    MedlinePlus

    ... Allergy Capitals Anaphylaxis in America Extreme Allergies and Climate Change Access to Pseudoephedrine Consensus Study on Food Allergies ... Allergy Capitals Anaphylaxis in America Extreme Allergies and Climate Change Access to Pseudoephedrine Consensus Study on Food Allergies ...

  14. Intellectual Capital.

    ERIC Educational Resources Information Center

    Van Horn, Royal

    2001-01-01

    According to Thomas Stewart's book, intellectual capital comprises three broad categories: human, structural, and customer. Structural, or organizational capital, is knowledge that does not leave at night (with workers, or human capital). Developing a "best practices" database using Lotus Notes software would preserve and access schools'…

  15. 78 FR 55339 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ...). \\10\\ See 77 FR 52856 (August 30, 2012). The NPR titled ``Regulatory Capital Rules: Advanced Approaches... Provisions, Prompt Corrective Action, Standardized Approach for Risk-weighted Assets, Market Discipline and Disclosure Requirements, Advanced Approaches Risk-Based Capital Rule, and Market Risk Capital Rule;...

  16. The thiG Gene Is Required for Full Virulence of Xanthomonas oryzae pv. oryzae by Preventing Cell Aggregation

    PubMed Central

    Yu, Xiaoyue; Liang, Xiaoyu; Liu, Kexue; Dong, Wenxia; Wang, Jianxin; Zhou, Ming-guo

    2015-01-01

    Bacterial blight of rice is an important serious bacterial diseases of rice in many rice-growing regions, caused by Xanthomonas oryzae pv. oryzae (Xoo). The thiG gene from Xoo strain ZJ173, which is involved with thiazole moiety production in the thiamine biosynthesis pathway, is highly conserved among the members of Xanthomonas. The thiG deletion mutant displayed impaired virulence and growth in thiamine-free medium but maintained its normal growth rate in the rice tissues, indicating that the thiG gene is involved in Xoo virulence. Compared to the wild type strain, the formation of cell-cell aggregates was affected in thiG deletion mutants. Although biofilm formation was promoted, motility and migration in rice leaves were repressed in the thiG mutants, and therefore limited the expansion of pathogen infection in rice. Quorum sensing and extracellular substance are two key factors that contribute to the formation of cell-cell aggregates. Our study found that in the thiG mutant the expression of two genes, rpfC and rpfG, which form a two-component regulatory signal system involved in the regulation of biofilm formation by a second messenger cyclic di-GMP is down-regulated. In addition, our study showed that xanthan production was not affected but the expression of some genes associated with xanthan biosynthesis, like gumD, gumE, gumH and gumM, were up-regulated in thiG mutants. Taken together, these findings are the first to demonstrate the role of the thiazole biosynthsis gene, thiG, in virulence and the formation of aggregates in Xanthomonas oryzae pv. oryzae. PMID:26222282

  17. 12 CFR 208.4 - Capital adequacy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Capital adequacy. 208.4 Section 208.4 Banks and... Requirements § 208.4 Capital adequacy. (a) Adequacy. A member bank's capital, as defined in appendix A to this... light of all the circumstances, the bank's capital appears inadequate in relation to its...

  18. 12 CFR 208.4 - Capital adequacy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Capital adequacy. 208.4 Section 208.4 Banks and... Requirements § 208.4 Capital adequacy. (a) Adequacy. A member bank's capital, as defined in appendix A to this... light of all the circumstances, the bank's capital appears inadequate in relation to its...

  19. Maximum Capital Project Management.

    ERIC Educational Resources Information Center

    Adams, Matt

    2002-01-01

    Describes the stages of capital project planning and development: (1) individual capital project submission; (2) capital project proposal assessment; (3) executive committee; and (4) capital project execution. (EV)

  20. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1995-01-01

    Part of the 1994 Industrial Minerals Review. The production, consumption, and applications of construction aggregates are reviewed. In 1994, the production of construction aggregates, which includes crushed stone and construction sand and gravel combined, increased 7.7 percent to 2.14 Gt compared with the previous year. These record production levels are mostly a result of funding for highway construction work provided by the Intermodal Surface Transportation Efficiency Act of 1991. Demand is expected to increase for construction aggregates in 1995.

  1. Square Footage Requirements for Use in Developing the Local Facilities Plans and State Capital Outlay Applications for Funding.

    ERIC Educational Resources Information Center

    Georgia State Dept. of Education, Atlanta. Facilities Services Unit.

    This document presents the space requirements for Georgia's elementary, middle, and high schools. All square footage requirements are computed by using inside dimensions of a room; the square footage of support spaces in suites may be included when computing the square footage of the suite. Examples of support spaces include storage rooms,…

  2. Weighted aggregation

    NASA Technical Reports Server (NTRS)

    Feiveson, A. H. (Principal Investigator)

    1979-01-01

    The use of a weighted aggregation technique to improve the precision of the overall LACIE estimate is considered. The manner in which a weighted aggregation technique is implemented given a set of weights is described. The problem of variance estimation is discussed and the question of how to obtain the weights in an operational environment is addressed.

  3. 12 CFR 325.103 - Capital measures and capital category definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR 28.15(b), or to comply with asset maintenance requirements pursuant to 12 CFR 28.20; or (B) The... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Capital measures and capital category... STATEMENTS OF GENERAL POLICY CAPITAL MAINTENANCE Prompt Corrective Action § 325.103 Capital measures...

  4. 12 CFR 325.103 - Capital measures and capital category definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CFR 28.15(b), or to comply with asset maintenance requirements pursuant to 12 CFR 28.20; or (B) The... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Capital measures and capital category... STATEMENTS OF GENERAL POLICY CAPITAL MAINTENANCE Prompt Corrective Action § 325.103 Capital measures...

  5. 77 FR 71568 - Capital, Margin, and Segregation Requirements for Security-Based Swap Dealers and Major Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... (October 18, 2012), which was published in FR Doc. 2012-26164 and appeared on page 70214 of the Federal Register on November 23, 2012 (77 FR 70214): 1. In footnote 172 in the first column of page 70233, the... requirements for broker-dealers permitted to use the alternative internal model- based method for computing...

  6. Charged Dust Aggregate Interactions

    NASA Astrophysics Data System (ADS)

    Matthews, Lorin; Hyde, Truell

    2015-11-01

    A proper understanding of the behavior of dust particle aggregates immersed in a complex plasma first requires a knowledge of the basic properties of the system. Among the most important of these are the net electrostatic charge and higher multipole moments on the dust aggregate as well as the manner in which the aggregate interacts with the local electrostatic fields. The formation of elongated, fractal-like aggregates levitating in the sheath electric field of a weakly ionized RF generated plasma discharge has recently been observed experimentally. The resulting data has shown that as aggregates approach one another, they can both accelerate and rotate. At equilibrium, aggregates are observed to levitate with regular spacing, rotating about their long axis aligned parallel to the sheath electric field. Since gas drag tends to slow any such rotation, energy must be constantly fed into the system in order to sustain it. A numerical model designed to analyze this motion provides both the electrostatic charge and higher multipole moments of the aggregate while including the forces due to thermophoresis, neutral gas drag, and the ion wakefield. This model will be used to investigate the ambient conditions leading to the observed interactions. This research is funded by NSF Grant 1414523.

  7. Construction aggregates

    USGS Publications Warehouse

    Langer, W.H.; Tepordei, V.V.; Bolen, W.P.

    2000-01-01

    Construction aggregates consist primarily of crushed stone and construction sand and gravel. Total estimated production of construction aggregates increased in 1999 by about 2% to 2.39 Gt (2.64 billion st) compared with 1998. This record production level continued an expansion that began in 1992. By commodities, crushed stone production increased 3.3%, while sand and gravel production increased by about 0.5%.

  8. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1994-01-01

    Part of a special section on industrial minerals in 1993. The 1993 production of construction aggregates increased 6.3 percent over the 1992 figure, to reach 2.01 Gt. This represents the highest estimated annual production of combined crushed stone and construction sand and gravel ever recorded in the U.S. The outlook for construction aggregates and the issues facing the industry are discussed.

  9. Projected Cropping Patterns, Livestock Enterprises, Processing Activities, Capital Requirements, Employment, Income, and Training Needs for Alternative Farm Organizational Structures for the Navajo Indian Irrigation Project. A Special Report to the Four Corners Regional Commission.

    ERIC Educational Resources Information Center

    Gorman, William D.; And Others

    Information on the expected cropping patterns, livestock enterprises, processing and related activities, income and employment opportunities, capital needs, and training requirements for alternative farm organizational structures that could be selected for development of the Navajo Indian Irrigation Project is presented in this report. The major…

  10. 12 CFR 28.14 - Limitations based upon capital of a foreign bank.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... must calculate its capital in a manner consistent with 12 CFR part 3, for purposes of this section. (c) Aggregation. The foreign bank shall aggregate business transacted by all Federal branches and agencies...

  11. Capital Campaigns.

    ERIC Educational Resources Information Center

    Dalessandro, David; And Others

    1989-01-01

    Eight articles focus on capital campaigns including setting goals (D. Dalessandro), the lead gift (D. A. Campbell), motivating trustees (J. J. Ianolli, Jr.), alumni associations (W. B. Adams), role of public relations officers (R. L. Williams), special events( H.R. Gilbert), the campaign document (R. King), and case statements (D. R. Treadwell,…

  12. A proposal for capital cost payment.

    PubMed

    Cleverley, W O

    1984-01-01

    This article proposes new bases for the payment of hospital capital costs. Separate distinctions between proprietary and voluntary hospitals are made based on their definition of capital and the requirements for capital maintenance. Replacement cost depreciation is suggested as the payment basis for voluntary hospitals. PMID:6373670

  13. Health, Human Capital, and Development*

    PubMed Central

    Bleakley, Hoyt

    2013-01-01

    How much does disease depress development in human capital and income around the world? I discuss a range of micro evidence, which finds that health is both human capital itself and an input to producing other forms of human capital. I use a standard model to integrate these results, and suggest a re-interpretation of much of the micro literature. I then discuss the aggregate implications of micro estimates, but note the complications in extrapolating to general equilibrium, especially because of health’s effect on population size. I also review the macro evidence on this topic, which consists of either cross-country comparisons or measuring responses to health shocks. Micro estimates are 1–2 orders of magnitude smaller than the cross-country relationship, but nevertheless imply high benefit-to-cost ratios from improving certain forms of health. PMID:24147187

  14. Holographic characterization of protein aggregates

    NASA Astrophysics Data System (ADS)

    Wang, Chen; Zhong, Xiao; Ruffner, David; Stutt, Alexandra; Philips, Laura; Ward, Michael; Grier, David

    Holographic characterization directly measures the size distribution of subvisible protein aggregates in suspension and offers insights into their morphology. Based on holographic video microscopy, this analytical technique records and interprets holograms of individual aggregates in protein solutions as they flow down a microfluidic channel, without requiring labeling or other exceptional sample preparation. The hologram of an individual protein aggregate is analyzed in real time with the Lorenz-Mie theory of light scattering to measure that aggregate's size and optical properties. Detecting, counting and characterizing subvisible aggregates proceeds fast enough for time-resolved studies, and lends itself to tracking trends in protein aggregation arising from changing environmental factors. No other analytical technique provides such a wealth of particle-resolved characterization data in situ. Holographic characterization promises accelerated development of therapeutic protein formulations, improved process control during manufacturing, and streamlined quality assurance during storage and at the point of use. Mrsec and MRI program of the NSF, Spheryx Inc.

  15. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1993-01-01

    Part of a special section on the market performance of industrial minerals in 1992. Production of construction aggregates increased by 4.6 percent in 1992. This increase was due, in part, to the increased funding for transportation and infrastructure projects. The U.S. produced about 1.05 Gt of crushed stone and an estimated 734 Mt of construction sand and gravel in 1992. Demand is expected to increase by about 5 percent in 1993.

  16. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1996-01-01

    Part of the Annual Commodities Review 1995. Production of construction aggregates such as crushed stone and construction sand and gravel showed a marginal increase in 1995. Most of the 1995 increases were due to funding for highway construction work. The major areas of concern to the industry included issues relating to wetlands classification and the classification of crystalline silica as a probable human carcinogen. Despite this, an increase in demand is anticipated for 1996.

  17. Construction aggregates

    USGS Publications Warehouse

    Nelson, T.I.; Bolen, W.P.

    2007-01-01

    Construction aggregates, primarily stone, sand and gravel, are recovered from widespread naturally occurring mineral deposits and processed for use primarily in the construction industry. They are mined, crushed, sorted by size and sold loose or combined with portland cement or asphaltic cement to make concrete products to build roads, houses, buildings, and other structures. Much smaller quantities are used in agriculture, cement manufacture, chemical and metallurgical processes, glass production and many other products.

  18. Sustainability in Supply Chain Management: Aggregate Planning from Sustainability Perspective.

    PubMed

    Türkay, Metin; Saraçoğlu, Öztürk; Arslan, Mehmet Can

    2016-01-01

    Supply chain management that considers the flow of raw materials, products and information has become a focal issue in modern manufacturing and service systems. Supply chain management requires effective use of assets and information that has far reaching implications beyond satisfaction of customer demand, flow of goods, services or capital. Aggregate planning, a fundamental decision model in supply chain management, refers to the determination of production, inventory, capacity and labor usage levels in the medium term. Traditionally standard mathematical programming formulation is used to devise the aggregate plan so as to minimize the total cost of operations. However, this formulation is purely an economic model that does not include sustainability considerations. In this study, we revise the standard aggregate planning formulation to account for additional environmental and social criteria to incorporate triple bottom line consideration of sustainability. We show how these additional criteria can be appended to traditional cost accounting in order to address sustainability in aggregate planning. We analyze the revised models and interpret the results on a case study from real life that would be insightful for decision makers. PMID:26807848

  19. Sustainability in Supply Chain Management: Aggregate Planning from Sustainability Perspective

    PubMed Central

    Türkay, Metin; Saraçoğlu, Öztürk; Arslan, Mehmet Can

    2016-01-01

    Supply chain management that considers the flow of raw materials, products and information has become a focal issue in modern manufacturing and service systems. Supply chain management requires effective use of assets and information that has far reaching implications beyond satisfaction of customer demand, flow of goods, services or capital. Aggregate planning, a fundamental decision model in supply chain management, refers to the determination of production, inventory, capacity and labor usage levels in the medium term. Traditionally standard mathematical programming formulation is used to devise the aggregate plan so as to minimize the total cost of operations. However, this formulation is purely an economic model that does not include sustainability considerations. In this study, we revise the standard aggregate planning formulation to account for additional environmental and social criteria to incorporate triple bottom line consideration of sustainability. We show how these additional criteria can be appended to traditional cost accounting in order to address sustainability in aggregate planning. We analyze the revised models and interpret the results on a case study from real life that would be insightful for decision makers. PMID:26807848

  20. Cholangiocyte Myosin IIB Is Required for Localized Aggregation of Sodium Glucose Cotransporter 1 to Sites of Cryptosporidium parvum Cellular Invasion and Facilitates Parasite Internalization ▿

    PubMed Central

    O'Hara, Steven P.; Gajdos, Gabriella B.; Trussoni, Christy E.; Splinter, Patrick L.; LaRusso, Nicholas F.

    2010-01-01

    Internalization of the obligate intracellular apicomplexan parasite, Cryptosporidium parvum, results in the formation of a unique intramembranous yet extracytoplasmic niche on the apical surfaces of host epithelial cells, a process that depends on host cell membrane extension. We previously demonstrated that efficient C. parvum invasion of biliary epithelial cells (cholangiocytes) requires host cell actin polymerization and localized membrane translocation/insertion of Na+/glucose cotransporter 1 (SGLT1) and of aquaporin 1 (Aqp1), a water channel, at the attachment site. The resultant localized water influx facilitates parasite cellular invasion by promoting host-cell membrane protrusion. However, the molecular mechanisms by which C. parvum induces membrane translocation/insertion of SGLT1/Aqp1 are obscure. We report here that cultured human cholangiocytes express several nonmuscle myosins, including myosins IIA and IIB. Moreover, C. parvum infection of cultured cholangiocytes results in the localized selective aggregation of myosin IIB but not myosin IIA at the region of parasite attachment, as assessed by dual-label immunofluorescence confocal microscopy. Concordantly, treatment of cells with the myosin light chain kinase inhibitor ML-7 or the myosin II-specific inhibitor blebbistatin or selective RNA-mediated repression of myosin IIB significantly inhibits (P < 0.05) C. parvum cellular invasion (by 60 to 80%). Furthermore ML-7 and blebbistatin significantly decrease (P < 0.02) C. parvum-induced accumulation of SGLT1 at infection sites (by approximately 80%). Thus, localized actomyosin-dependent membrane translocation of transporters/channels initiated by C. parvum is essential for membrane extension and parasite internalization, a phenomenon that may also be relevant to the mechanisms of cell membrane protrusion in general. PMID:20457792

  1. 12 CFR 652.70 - Risk-based capital level.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Risk-based capital level. 652.70 Section 652.70... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.70 Risk-based capital level. The risk-based capital level is the sum of the following amounts: (a) Credit and interest rate risk....

  2. 12 CFR 652.70 - Risk-based capital level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Risk-based capital level. 652.70 Section 652.70... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.70 Risk-based capital level. The risk-based capital level is the sum of the following amounts: (a) Credit and interest rate risk....

  3. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the bank... undercapitalized is not required to submit a capital restoration plan solely by virtue of the reclassification....

  4. 12 CFR 1777.23 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... An Enterprise shall file a capital restoration plan in writing with OFHEO within ten days of... a capital restoration plan approved by OFHEO under this part is not required to submit an additional capital restoration plan based on a subsequent notice of capital classification, unless OFHEO notifies...

  5. 12 CFR 1777.23 - Capital restoration plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... An Enterprise shall file a capital restoration plan in writing with OFHEO within ten days of... a capital restoration plan approved by OFHEO under this part is not required to submit an additional capital restoration plan based on a subsequent notice of capital classification, unless OFHEO notifies...

  6. 12 CFR 1777.23 - Capital restoration plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... An Enterprise shall file a capital restoration plan in writing with OFHEO within ten days of... a capital restoration plan approved by OFHEO under this part is not required to submit an additional capital restoration plan based on a subsequent notice of capital classification, unless OFHEO notifies...

  7. 12 CFR 1777.23 - Capital restoration plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... An Enterprise shall file a capital restoration plan in writing with OFHEO within ten days of... a capital restoration plan approved by OFHEO under this part is not required to submit an additional capital restoration plan based on a subsequent notice of capital classification, unless OFHEO notifies...

  8. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the bank... undercapitalized is not required to submit a capital restoration plan solely by virtue of the reclassification....

  9. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the bank... undercapitalized is not required to submit a capital restoration plan solely by virtue of the reclassification....

  10. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the bank... undercapitalized is not required to submit a capital restoration plan solely by virtue of the reclassification....

  11. 12 CFR 652.70 - Risk-based capital level.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Risk-based capital level. 652.70 Section 652.70... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.70 Risk-based capital level. The risk-based capital level is the sum of the following amounts: (a) Credit and interest rate risk....

  12. 12 CFR 652.70 - Risk-based capital level.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Risk-based capital level. 652.70 Section 652.70... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.70 Risk-based capital level. The risk-based capital level is the sum of the following amounts: (a) Credit and interest rate risk....

  13. 12 CFR 652.70 - Risk-based capital level.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Risk-based capital level. 652.70 Section 652.70... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.70 Risk-based capital level. The risk-based capital level is the sum of the following amounts: (a) Credit and interest rate risk....

  14. Capital cost estimate

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The capital cost estimate for the nuclear process heat source (NPHS) plant was made by: (1) using costs from the current commercial HTGR for electricity production as a base for items that are essentially the same and (2) development of new estimates for modified or new equipment that is specifically for the process heat application. Results are given in tabular form and cover the total investment required for each process temperature studied.

  15. Construction aggregates

    USGS Publications Warehouse

    Bolen, W.P.; Tepordei, V.V.

    2001-01-01

    The estimated production during 2000 of construction aggregates, crushed stone, and construction sand and gravel increased by about 2.6% to 2.7 Gt (3 billion st), compared with 1999. The expansion that started in 1992 continued with record production levels for the ninth consecutive year. By commodity, construction sand and gravel production increased by 4.5% to 1.16 Gt (1.28 billion st), while crushed stone production increased by 1.3% to 1.56 Gt (1.72 billion st).

  16. Social capital in engineering education

    NASA Astrophysics Data System (ADS)

    Brown, Shane

    A theoretical argument is presented to suggest that engineering curriculum be designed to develop social capital. Additionally, the value of social capital in the retention of students in the College of Engineering, and the development, role, and value of social capital in an electrical engineering laboratory is evaluated. Data collected includes participant observations, informal and formal student interviews, and a researcher-designed survey. Social capital consists of interaction among individuals (networks), social rules that encourage interactions such as trust and reciprocity (norms), and the value of these networks and norms to the individual and the group. A large body of evidence suggests that social capital is valuable in terms of retention and multiple measures of academic achievement. The importance of social capital in retention was verified by students that have left engineering and those that remain, in terms of interactions with peers, teaching assistants, and engineering faculty; and a lack of sense of community in freshman engineering courses. Students that have left engineering differed in their perceptions of social capital from those that remain in their frustrations with teaching methods that encourage little discussion or opportunities to ask questions about assumptions or approaches. The open-ended nature of laboratory assignments, extensive required troubleshooting, and lack of specific directions from the teaching assistants were found to encourage the development of social capital in the laboratory setting. Degree centrality, a network measure of social capital as the number of ties an individual has within a social network, was found to be positively correlated with laboratory grade. Student perceptions of the importance of interactions with other students on success in the laboratory setting has a negative model effect on academic achievement in the laboratory. In contrast, student perceptions of the quality of interactions with

  17. The dynamics of social capital and health.

    PubMed

    Lavalle, Tiziana; Omosebi, Charles Damimola; Desmarteau, Robert H

    2015-01-01

    In the wake of Robert Putnam's arrival in Italy to study regionalization, this review of the literature on social capital aimed to establish whether current knowledge, social or socio-anthropological research have yielded new findings on how social capital is built and maintained or developed in a community and to what extent this influences social well-being. This is particularly important for those working in the health sector to make sure that health-related decision-making and behaviour foster rather than destroy the development of social capital. Our literature search was based on specific articles published in scientific journals in the humanist, managerial and medical fields, book titles or subtitles containing references to "social capital or social cooperation or reciprocity". Our findings led us to the conclusion that a complex series of coordinated actions are required for social capital to develop and that, once developed, social capital has a positive impact on social relations, economic results and social stability. In addition, we understood why it is useful to retain three stages, conditioning, development and capitalization, in modelling the development of social capital. Conditioning requires transparency, pragmatism and long-term vision. Development and capitalization require the predominant variables to be chosen. The development of social capital is part of a good strategy for health promotion and prevention. PMID:26828341

  18. Monosized aggregates -- A new model

    SciTech Connect

    Gopal, M.

    1997-08-01

    For applications requiring colloidal particles, it is desirable that they be monosized to better control the structure and the properties. In a number of systems, the monosized particles come together to form aggregates that are also monosized. A model is presented here to explain the formation of these monosized aggregates. This is of particular importance in the fields of ceramics, catalysis, pigments, pharmacy, photographic emulsions, etc.

  19. Cointegration of output, capital, labor, and energy

    NASA Astrophysics Data System (ADS)

    Stresing, R.; Lindenberger, D.; Kã¼mmel, R.

    2008-11-01

    Cointegration analysis is applied to the linear combinations of the time series of (the logarithms of) output, capital, labor, and energy for Germany, Japan, and the USA since 1960. The computed cointegration vectors represent the output elasticities of the aggregate energy-dependent Cobb-Douglas function. The output elasticities give the economic weights of the production factors capital, labor, and energy. We find that they are for labor much smaller and for energy much larger than the cost shares of these factors. In standard economic theory output elasticities equal cost shares. Our heterodox findings support results obtained with LINEX production functions.

  20. Capital disadvantage: America's failing capital investment system.

    PubMed

    Porter, M E

    1992-01-01

    The U.S. system of allocating investment capital is failing, putting American companies at a serious disadvantage and threatening the long-term growth of the nation's economy. The problem, says Michael Porter, goes beyond the usual formulation of the issue: accusations of "short-termism" by U.S. managers, ineffective corporate governance by directors, or a high cost of capital. The problem involves the external capital allocation system by which capital is provided to companies, as well as the system by which companies allocate capital internally. America's system is marked by fluid capital and a financial focus. Other countries--notably Japan and Germany--have systems with dedicated capital and a focus on corporate position. In global competition, where investment increasingly determines a company's capacity to upgrade and innovate, the U.S. system does not measure up. These conclusions come out of a two-year research project sponsored by the Harvard Business School and the Council on Competitiveness. Porter recommends five far-reaching reforms to make the U.S. system superior to Japan's and Germany's: 1. Improve the present macroeconomic environment. 2. Expand true ownership throughout the system so that directors, managers, employees, and even customers and suppliers hold positions as owners. 3. Align the goals of capital providers, corporations, directors, managers, employees, customers, suppliers, and society. 4. Improve the information used in decision making. 5. Foster more productive modes of interaction and influence among capital providers, corporations, and business units. PMID:10121317

  1. Reaping benefits from intellectual capital.

    PubMed

    Weston, Marla J; Estrada, Nicolette A; Carrington, Jane

    2007-01-01

    The wealth and value of organizations are increasingly based on intellectual capital. Although acquiring talented individuals and investing in employee learning adds value to the organization, reaping the benefits of intellectual capital involves translating the wisdom of employees into reusable and sustained actions. This requires a culture that creates employee commitment, encourages learning, fosters sharing, and involves employees in decision making. An infrastructure to recognize and embed promising and best practices through social networks, evidence-based practice, customization of innovations, and use of information technology results in increased productivity, stronger financial performance, better patient outcomes, and greater employee and customer satisfaction. PMID:17198112

  2. 78 FR 76973 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... the authority for 12 CFR part 208. In the Final Rule, FR Doc. 2013-21653, published on October 11, 2013 (78 FR 62018), please correct the following: PART 208-- 0 1. Revise the authority for 12 CFR part... risk-based and leverage capital requirements for banking organizations. This document adds...

  3. Slipped capital femoral epiphysis

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/000972.htm Slipped capital femoral epiphysis To use the sharing features on this page, please enable JavaScript. A slipped capital femoral epiphysis is a separation of the ball ...

  4. 12 CFR 704.3 - Corporate credit union capital.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Corporate credit union capital. 704.3 Section 704.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS CORPORATE CREDIT UNIONS § 704.3 Corporate credit union capital. (a) Capital requirements. (1) A...

  5. 12 CFR 704.3 - Corporate credit union capital.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Corporate credit union capital. 704.3 Section 704.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS CORPORATE CREDIT UNIONS § 704.3 Corporate credit union capital. (a) Capital requirements. (1) A...

  6. 7 CFR 3560.64 - Initial operating capital contribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Initial operating capital contribution. 3560.64... § 3560.64 Initial operating capital contribution. Borrowers are required to make an initial operating capital contribution to the general operating account in the amount of at least 2 percent of the...

  7. 24 CFR 891.165 - Duration of capital advance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Duration of capital advance. 891... General Program Requirements § 891.165 Duration of capital advance. The duration of the fund reservation for the capital advance is 18 months from the date of issuance with limited exceptions up to 24...

  8. 24 CFR 891.165 - Duration of capital advance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Duration of capital advance. 891... General Program Requirements § 891.165 Duration of capital advance. The duration of the fund reservation for the capital advance is 18 months from the date of issuance with limited exceptions up to 24...

  9. 24 CFR 891.170 - Repayment of capital advance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Repayment of capital advance. 891... General Program Requirements § 891.170 Repayment of capital advance. (a) Interest prohibition and repayment. A capital advance provided under this part shall bear no interest and its repayment shall not...

  10. 24 CFR 891.170 - Repayment of capital advance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Repayment of capital advance. 891... General Program Requirements § 891.170 Repayment of capital advance. (a) Interest prohibition and repayment. A capital advance provided under this part shall bear no interest and its repayment shall not...

  11. 12 CFR 1229.11 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... change over the term of the plan; (3) Specify the types and levels of activities in which the Bank will... Director, in his or her sole discretion, may approve amendments to an approved capital restoration plan if... capital to levels sufficient to fulfill its risk-based and minimum capital requirements within...

  12. 12 CFR 1229.11 - Capital restoration plans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... change over the term of the plan; (3) Specify the types and levels of activities in which the Bank will... Director, in his or her sole discretion, may approve amendments to an approved capital restoration plan if... capital to levels sufficient to fulfill its risk-based and minimum capital requirements within...

  13. 12 CFR 208.44 - Capital restoration plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Action § 208.44 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A member bank shall file a written capital restoration plan with the appropriate Reserve Bank within 45 days of the... is not required to submit a capital restoration plan solely by virtue of the reclassification....

  14. 12 CFR 208.44 - Capital restoration plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Action § 208.44 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A member bank shall file a written capital restoration plan with the appropriate Reserve Bank within 45 days of the... is not required to submit a capital restoration plan solely by virtue of the reclassification....

  15. 12 CFR 208.44 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Action § 208.44 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A member bank shall file a written capital restoration plan with the appropriate Reserve Bank within 45 days of the... is not required to submit a capital restoration plan solely by virtue of the reclassification....

  16. 12 CFR 208.44 - Capital restoration plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Action § 208.44 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A member bank shall file a written capital restoration plan with the appropriate Reserve Bank within 45 days of the... is not required to submit a capital restoration plan solely by virtue of the reclassification....

  17. 12 CFR 390.454 - Capital restoration plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Capital restoration plans. (a) Schedule for filing plan—(1) In general. A State savings association shall file a written capital restoration plan with the appropriate Regional Office within 45 days of the date... not required to submit a capital restoration plan solely by virtue of the reclassification....

  18. 12 CFR 390.454 - Capital restoration plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Capital restoration plans. (a) Schedule for filing plan—(1) In general. A State savings association shall file a written capital restoration plan with the appropriate Regional Office within 45 days of the date... not required to submit a capital restoration plan solely by virtue of the reclassification....

  19. IfkA, a presumptive eIF2α kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size

    PubMed Central

    Fang, Rui; Xiong, Yanhua; Singleton, Charles K

    2003-01-01

    Background The transition from growth to development in Dictyostelium is initiated by amino acid starvation of growing amobae. In other eukaryotes, a key sensor of amino acid starvation and mediator of the resulting physiological responses is the GCN2 protein, an eIF2α kinase. GCN2 downregulates the initiation of translation of bulk mRNA and enhances translation of specific mRNAs by phosphorylating the translation initiation factor eIF2α. Two eIF2α kinases were identified in Dictyostelium and studied herein. Results Neither of the eIF2α kinases appeared to be involved in sensing amino acid starvation to initiate development. However, one of the kinases, IfkA, was shown to phosphorylate eIF2α from 1 to 7 hours after the onset of development, resulting in a shift from polysomes to free ribosomes for bulk mRNA. In the absence of the eIF2α phosphorylation, ifkA null cells aggregated earlier than normal and formed mounds and ultimately fruiting bodies that were larger than normal. The early aggregation phenotype in ifkA null cells reflected an apparent, earlier than normal establishment of the cAMP pulsing system. The large mound phenotype resulted from a reduced extracellular level of Countin, a component of the counting factor that regulates mound size. In wild type cells, phosphorylation of eIF2α by IfkA resulted in a specific stabilization and enhanced translational efficiency of countin mRNA even though reduced translation resulted for bulk mRNA. Conclusions IfkA is an eIF2α kinase of Dictyostelium that normally phosphorylates eIF2α from 1 to 7 hours after the onset of development, or during the preaggregation phase. This results in an overall reduction in the initiation of protein synthesis during this time frame and a concomitant reduction in the number of ribosomes associated with most mRNAs. For some mRNAs, however, initiation of protein synthesis is enhanced or stabilized under the conditions of increased eIF2α phosphorylation. This includes countin

  20. Aggregate breakdown of nanoparticulate titania

    NASA Astrophysics Data System (ADS)

    Venugopal, Navin

    Six nanosized titanium dioxide powders synthesized from a sulfate process were investigated. The targeted end-use of this powder was for a de-NOx catalyst honeycomb monolith. Alteration of synthesis parameters had resulted principally in differences in soluble ion level and specific surface area of the powders. The goal of this investigation was to understand the role of synthesis parameters in the aggregation behavior of these powders. Investigation via scanning electron microscopy of the powders revealed three different aggregation iterations at specific length scales. Secondary and higher order aggregate strength was investigated via oscillatory stress rheometry as a means of simulating shear conditions encountered during extrusion. G' and G'' were measured as a function of the applied oscillatory stress. Oscillatory rheometry indicated a strong variation as a function of the sulfate level of the particles in the viscoelastic yield strengths. Powder yield stresses ranged from 3.0 Pa to 24.0 Pa of oscillatory stress. Compaction curves to 750 MPa found strong similarities in extrapolated yield point of stage I and II compaction for each of the powders (at approximately 500 MPa) suggesting that the variation in sulfate was greatest above the primary aggregate level. Scanning electron microscopy of samples at different states of shear in oscillatory rheometry confirmed the variation in the linear elastic region and the viscous flow regime. A technique of this investigation was to approach aggregation via a novel perspective: aggregates are distinguished as being loose open structures that are highly disordered and stochastic in nature. The methodology used was to investigate the shear stresses required to rupture the various aggregation stages encountered and investigate the attempt to realign the now free-flowing constituents comprising the aggregate into a denser configuration. Mercury porosimetry was utilized to measure the pore size of the compact resulting from

  1. 12 CFR 324.403 - Capital measures and capital category definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OCC to increase its capital equivalency deposit pursuant to 12 CFR 28.15, or to comply with asset maintenance requirements pursuant to 12 CFR 28.20; or (B) The FDIC to pledge additional assets pursuant to... 38 of the FDI Act and this subpart H, the relevant capital measures shall be: (1) The total...

  2. A review of volcanic ash aggregation

    NASA Astrophysics Data System (ADS)

    Brown, R. J.; Bonadonna, C.; Durant, A. J.

    2012-01-01

    Most volcanic ash particles with diameters <63 μm settle from eruption clouds as particle aggregates that cumulatively have larger sizes, lower densities, and higher terminal fall velocities than individual constituent particles. Particle aggregation reduces the atmospheric residence time of fine ash, which results in a proportional increase in fine ash fallout within 10-100 s km from the volcano and a reduction in airborne fine ash mass concentrations 1000 s km from the volcano. Aggregate characteristics vary with distance from the volcano: proximal aggregates are typically larger (up to cm size) with concentric structures, while distal aggregates are typically smaller (sub-millimetre size). Particles comprising ash aggregates are bound through hydro-bonds (liquid and ice water) and electrostatic forces, and the rate of particle aggregation correlates with cloud liquid water availability. Eruption source parameters (including initial particle size distribution, erupted mass, eruption column height, cloud water content and temperature) and the eruption plume temperature lapse rate, coupled with the environmental parameters, determines the type and spatiotemporal distribution of aggregates. Field studies, lab experiments and modelling investigations have already provided important insights on the process of particle aggregation. However, new integrated observations that combine remote sensing studies of ash clouds with field measurement and sampling, and lab experiments are required to fill current gaps in knowledge surrounding the theory of ash aggregate formation.

  3. Fueling innovation in medical devices (and beyond): venture capital in health care.

    PubMed

    Ackerly, D Clay; Valverde, Ana M; Diener, Lawrence W; Dossary, Kristin L; Schulman, Kevin A

    2009-01-01

    Innovation in health care requires new ideas and the capital to develop and commercialize those ideas into products or services. The necessary capital is often "venture capital," but the link between public policy and the venture capital industry has not been well examined. In this paper we explore the link between venture capital and innovation in health care, and we present new descriptive data from a survey of health care venture capital fund managers. Respondents generally viewed policy levers (for example, reimbursement and regulations) as important risks to venture capital investments, potentially affecting their ability to raise capital for early-stage investment funds. PMID:19049999

  4. Platelet aggregation test

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003669.htm Platelet aggregation test To use the sharing features on this page, please enable JavaScript. The platelet aggregation blood test checks how well platelets , a ...

  5. Thermodynamics of Protein Aggregation

    NASA Astrophysics Data System (ADS)

    Osborne, Kenneth L.; Barz, Bogdan; Bachmann, Michael; Strodel, Birgit

    Amyloid protein aggregation characterizes many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Creutz- feldt-Jakob disease. Evidence suggests that amyloid aggregates may share similar aggregation pathways, implying simulation of full-length amyloid proteins is not necessary for understanding amyloid formation. In this study we simulate GNNQQNY, the N-terminal prion-determining domain of the yeast protein Sup35 to investigate the thermodynamics of structural transitions during aggregation. We use a coarse-grained model with replica-exchange molecular dynamics to investigate the association of 3-, 6-, and 12-chain GNNQQNY systems and we determine the aggregation pathway by studying aggregation states of GN- NQQNY. We find that the aggregation of the hydrophilic GNNQQNY sequence is mainly driven by H-bond formation, leading to the formation of /3-sheets from the very beginning of the assembly process. Condensation (aggregation) and ordering take place simultaneously, which is underpinned by the occurrence of a single heat capacity peak only.

  6. Platelet aggregation test

    MedlinePlus

    The platelet aggregation blood test checks how well platelets , a part of blood, clump together and cause blood to clot. ... Decreased platelet aggregation may be due to: Autoimmune ... Fibrin degradation products Inherited platelet function defects ...

  7. 76 FR 65537 - Controlled Substances: Proposed Aggregate Production Quotas for 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... Enforcement Administration Controlled Substances: Proposed Aggregate Production Quotas for 2012 AGENCY: Drug...: This notice proposes initial year 2012 aggregate production quotas for controlled substances in....S.C. 826) requires that the Attorney General establish aggregate production quotas for each...

  8. 12 CFR 1229.3 - Criteria for a Bank's capital classification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements but such deficiency is not of a magnitude to classify the Bank as significantly undercapitalized... minimum capital requirements but the magnitude of the Bank's deficiency in total capital is not...

  9. 12 CFR 1229.3 - Criteria for a Bank's capital classification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements but such deficiency is not of a magnitude to classify the Bank as significantly undercapitalized... minimum capital requirements but the magnitude of the Bank's deficiency in total capital is not...

  10. 12 CFR 1229.3 - Criteria for a Bank's capital classification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements but such deficiency is not of a magnitude to classify the Bank as significantly undercapitalized... minimum capital requirements but the magnitude of the Bank's deficiency in total capital is not...

  11. 12 CFR 1229.3 - Criteria for a Bank's capital classification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements but such deficiency is not of a magnitude to classify the Bank as significantly undercapitalized... minimum capital requirements but the magnitude of the Bank's deficiency in total capital is not...

  12. 12 CFR 652.75 - Your responsibility for determining the risk-based capital level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the risk-based capital stress test and must be able to determine your risk-based capital level at any...-based capital level. 652.75 Section 652.75 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT... Requirements § 652.75 Your responsibility for determining the risk-based capital level. (a) You must...

  13. 12 CFR 652.65 - Risk-based capital stress test.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Risk-based capital stress test. 652.65 Section... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.65 Risk-based capital stress test. You will perform the risk-based capital stress test as described in summary form below and...

  14. 12 CFR 652.65 - Risk-based capital stress test.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Risk-based capital stress test. 652.65 Section... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.65 Risk-based capital stress test. You will perform the risk-based capital stress test as described in summary form below and...

  15. 12 CFR 652.65 - Risk-based capital stress test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Risk-based capital stress test. 652.65 Section... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.65 Risk-based capital stress test. You will perform the risk-based capital stress test as described in summary form below and...

  16. 12 CFR Appendix B to Part 325 - Statement of Policy on Capital Adequacy

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Capital Adequacy Part 325 of the Federal Deposit Insurance Corporation rules and regulations (12 CFR part... nonmember banks which are subject to § 337.4 of the FDIC's rules and regulations (12 CFR 337.4). Any... capital leverage, tangible capital and risk-based capital requirements for savings associations (12...

  17. 12 CFR 325.4 - Inadequate capital as an unsafe or unsound practice or condition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Inadequate capital as an unsafe or unsound... REGULATIONS AND STATEMENTS OF GENERAL POLICY CAPITAL MAINTENANCE Minimum Capital Requirements § 325.4 Inadequate capital as an unsafe or unsound practice or condition. (a) General. As a condition of...

  18. 12 CFR 325.4 - Inadequate capital as an unsafe or unsound practice or condition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Inadequate capital as an unsafe or unsound... REGULATIONS AND STATEMENTS OF GENERAL POLICY CAPITAL MAINTENANCE Minimum Capital Requirements § 325.4 Inadequate capital as an unsafe or unsound practice or condition. (a) General. As a condition of...

  19. 12 CFR Appendix B to Part 325 - Statement of Policy on Capital Adequacy

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Capital Adequacy Part 325 of the Federal Deposit Insurance Corporation rules and regulations (12 CFR part... nonmember banks which are subject to § 337.4 of the FDIC's rules and regulations (12 CFR 337.4). Any... capital leverage, tangible capital and risk-based capital requirements for savings associations (12...

  20. 12 CFR 652.65 - Risk-based capital stress test.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Risk-based capital stress test. 652.65 Section... CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.65 Risk-based capital stress test. You will perform the risk-based capital stress test as described in summary form below and...

  1. Rate adjusters for Medicare under capitation

    PubMed Central

    Newhouse, Joseph P.

    1986-01-01

    This article addresses three issues related to capitation. First, the average adjusted per capita cost (AAPCC) fluctuates with the mix of risks in the fee-for-service system. More sensitive adjusters in the AAPCC are needed. Second, the AAPCC, as now estimated, exhibits large geographic variance; so-called shrinkage estimators may help. Third, the AAPCC requires new adjusters to yield more homogeneous risk classes. Otherwise, the portion of the Medicare population under capitation may experience access problems at alternative delivery systems: Until such adjusters are developed, it seems better to rely upon a blend of capitation and fee-for-service than the present AAPCC. PMID:10311926

  2. Natural aggregates of the conterminous United States

    USGS Publications Warehouse

    Langer, William H.

    1988-01-01

    Crushed stone and sand and gravel are the two main sources of natural aggregates. These materials are commonly used construction materials and frequently can be interchanged with one another. They are widely used throughout the United States, with every State except two producing crushed stone. Together they amount to about half the mining volume in the United States. Approximately 96 percent of sand and gravel and 77 percent of the crushed stone produced in the United States are used in the construction industry. Natural aggregates are widely distributed throughout the United States in a variety of geologic environments. Sand and gravel deposits commonly are the results of the weathering of bedrock and subsequent transportation and deposition of the material by water or ice (glaciers). As such, they commonly occur as river or stream deposits or in glaciated areas as glaciofluvial and other deposits. Crushed stone aggregates are derived from a wide variety of parent bedrock materials. Limestone and other carbonates account for approximately three quarters of the rocks used for crushed stone, with granite and other igneous rocks making up the bulk of the remainder. Limestone deposits are widespread throughout the Central and Eastern United States and are scattered in the West. Granites are widely distributed in the Eastern and Western United States, with few exposures in the Midwest. Igneous rocks (excluding granites) are largely concentrated in the Western United States and in a few isolated localities in the East. Even though natural aggregates are widely distributed throughout the United States, they are not universally available for consumptive use. Some areas are devoid of sand and gravel, and potential sources of crushed stone may be covered with sufficient unconsolidated material to make surface mining impractical. In some areas many aggregates do not meet the physical property requirements for certain uses, or they may contain mineral constituents that react

  3. Environmentalism and natural aggregate mining

    USGS Publications Warehouse

    Drew, L.J.; Langer, W.H.; Sachs, J.S.

    2002-01-01

    Sustaining a developed economy and expanding a developing one require the use of large volumes of natural aggregate. Almost all human activity (commercial, recreational, or leisure) is transacted in or on facilities constructed from natural aggregate. In our urban and suburban worlds, we are almost totally dependent on supplies of water collected behind dams and transported through aqueducts made from concrete. Natural aggregate is essential to the facilities that produce energy-hydroelectric dams and coal-fired powerplants. Ironically, the utility created for mankind by the use of natural aggregate is rarely compared favorably with the environmental impacts of mining it. Instead, the empty quarries and pits are seen as large negative environmental consequences. At the root of this disassociation is the philosophy of environmentalism, which flavors our perceptions of the excavation, processing, and distribution of natural aggregate. The two end-member ideas in this philosophy are ecocentrism and anthropocentrism. Ecocentrism takes the position that the natural world is a organism whose arteries are the rivers-their flow must not be altered. The soil is another vital organ and must not be covered with concrete and asphalt. The motto of the ecocentrist is "man must live more lightly on the land." The anthropocentrist wants clean water and air and an uncluttered landscape for human use. Mining is allowed and even encouraged, but dust and noise from quarry and pit operations must be minimized. The large volume of truck traffic is viewed as a real menace to human life and should be regulated and isolated. The environmental problems that the producers of natural aggregate (crushed stone and sand and gravel) face today are mostly difficult social and political concerns associated with the large holes dug in the ground and the large volume of heavy truck traffic associated with quarry and pit operations. These concerns have increased in recent years as society's demand for

  4. Access to capital: implications for hospital consolidation.

    PubMed

    Grauman, Daniel M; Harris, John M; Martin, Christine

    2010-04-01

    Recent economic challenges have left many independent hospitals and their boards concerned about long-term viability of their organizations as stand-alone facilities. The CFO's role should be to facilitate a candid, objective assessment of the organization's ability to continue to go it alone. Key indicators that should be considered in such an assessment include patient volume, degree of physician alignment, profitability, current debt burden, cash, available capital versus capital requirements, and credit rating changes. PMID:20358877

  5. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition...

  6. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition...

  7. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition...

  8. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition...

  9. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition...

  10. Slipped capital femoral epiphysis

    MedlinePlus

    A slipped capital femoral epiphysis is a separation of the ball of the hip joint from the thigh bone (femur) at ... A slipped capital femoral epiphysis may affect both hips. An epiphysis is an area at the end of a long bone . ...

  11. Productivity and Capital Goods.

    ERIC Educational Resources Information Center

    Zicht, Barbara, Ed.; And Others

    1981-01-01

    Providing teacher background on the concepts of productivity and capital goods, this document presents 3 teaching units about these ideas for different grade levels. The grade K-2 unit, "How Do They Do It?," is designed to provide students with an understanding of how physical capital goods add to productivity. Activities include a field trip to…

  12. Linguistic Capital Pays Dividends

    ERIC Educational Resources Information Center

    Linse, Caroline

    2013-01-01

    Some 37 million U.S. residents speak Spanish at home and more than 55% of them say they also speak English. That creates what is called linguistic capital. Although linguistic capital is difficult to quantify, it is enormously valuable and is determined by an individual's language competency, and is too frequently wasted instead of being…

  13. Financing Human Capital.

    ERIC Educational Resources Information Center

    Juffras, Jason; Sawhill, Isabel V.

    This paper examines the government's role in financing human capital investments. It first examines why private investments in education, training, and other forms of human capital are likely to fall short of socially desirable levels. It then reviews past trends in public support for human resource investments. Finally, it discusses current…

  14. A Comparative Analysis of the Validity of US State- and County-Level Social Capital Measures and Their Associations with Population Health

    ERIC Educational Resources Information Center

    Lee, Chul-Joo; Kim, Daniel

    2013-01-01

    The goals of this study were to validate a number of available collective social capital measures at the US state and county levels, and to examine the relative extent to which these social capital measures are associated with population health outcomes. Measures of social capital at the US state level included aggregate indices based on the…

  15. 12 CFR 325.104 - Capital restoration plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... filing plan—(1) In general. A bank shall file a written capital restoration plan with the appropriate... supervisory actions as if the bank were undercapitalized is not required to submit a capital restoration plan... restoration plan approved under section 38 and this subpart is not required to submit an additional...

  16. 12 CFR 325.104 - Capital restoration plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... filing plan—(1) In general. A bank shall file a written capital restoration plan with the appropriate... supervisory actions as if the bank were undercapitalized is not required to submit a capital restoration plan... restoration plan approved under section 38 and this subpart is not required to submit an additional...

  17. 12 CFR 325.104 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... filing plan—(1) In general. A bank shall file a written capital restoration plan with the appropriate... supervisory actions as if the bank were undercapitalized is not required to submit a capital restoration plan... restoration plan approved under section 38 and this subpart is not required to submit an additional...

  18. 12 CFR 325.104 - Capital restoration plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... filing plan—(1) In general. A bank shall file a written capital restoration plan with the appropriate... supervisory actions as if the bank were undercapitalized is not required to submit a capital restoration plan... restoration plan approved under section 38 and this subpart is not required to submit an additional...

  19. Approaches of Russian oil companies to optimal capital structure

    NASA Astrophysics Data System (ADS)

    Ishuk, T.; Ulyanova, O.; Savchitz, V.

    2015-11-01

    Oil companies play a vital role in Russian economy. Demand for hydrocarbon products will be increasing for the nearest decades simultaneously with the population growth and social needs. Change of raw-material orientation of Russian economy and the transition to the innovative way of the development do not exclude the development of oil industry in future. Moreover, society believes that this sector must bring the Russian economy on to the road of innovative development due to neo-industrialization. To achieve this, the government power as well as capital management of companies are required. To make their optimal capital structure, it is necessary to minimize the capital cost, decrease definite risks under existing limits, and maximize profitability. The capital structure analysis of Russian and foreign oil companies shows different approaches, reasons, as well as conditions and, consequently, equity capital and debt capital relationship and their cost, which demands the effective capital management strategy.

  20. Risky business: reporting and recording issues for capitated HMOs.

    PubMed

    Kazahaya, G I

    1986-10-01

    In the August issue of HFM, risked-based, risk-sharing, capitated HMO plans were defined. In this issue, the risks involved in entering into agreements with these plans and the financial recording and reporting issues to be considered when integrating the current system with capitated HMO reporting are considered. Implementation of capitation programs will require adjustments for the hospital. These programs will require changes to the hospital's database and an extensive analysis of how flexible budgeting will be affected, how capitation can be integrated into current productivity systems, and how traditional approaches of managing hospitals must be changed. PMID:10278536

  1. Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations.

    PubMed

    Barnett, Gregory V; Qi, Wei; Amin, Samiul; Neil Lewis, E; Roberts, Christopher J

    2015-12-01

    Non-native aggregation is a common issue in a number of degenerative diseases and during manufacturing of protein-based therapeutics. There is a growing interest to monitor protein stability at intermediate to high protein concentrations, which are required for therapeutic dosing of subcutaneous injections. An understanding of the impact of protein structural changes and interactions on the protein aggregation mechanisms and resulting aggregate size and morphology may lead to improved strategies to reduce aggregation and solution viscosity. This report investigates non-native aggregation of a model protein, α-chymotrypsinogen, under accelerated conditions at elevated protein concentrations. Far-UV circular dichroism and Raman scattering show structural changes during aggregation. Size exclusion chromatography and laser light scattering are used to monitor the progression of aggregate growth and monomer loss. Monomer loss is concomitant with increased β-sheet structures as monomers are added to aggregates, which illustrate a transition from a native monomeric state to an aggregate state. Aggregates grow predominantly through monomer-addition, resulting in a semi-flexible polymer morphology. Analysis of aggregation growth kinetics shows that pH strongly affects the characteristic timescales for nucleation (τn) and growth (τg), while the initial protein concentration has only minor effects on τn or τg. Low-shear viscosity measurements follow a common scaling relationship between average aggregate molecular weight (Mw(agg)) and concentration (σ), which is consistent with semi-dilute polymer-solution theory. The results establish a link between aggregate growth mechanisms, which couple Mw(agg) and σ, to increases in solution viscosity even at these intermediate protein concentrations (less than 3w/v %). PMID:26284891

  2. Aggregations in Flatworms.

    ERIC Educational Resources Information Center

    Liffen, C. L.; Hunter, M.

    1980-01-01

    Described is a school project to investigate aggregations in flatworms which may be influenced by light intensity, temperature, and some form of chemical stimulus released by already aggregating flatworms. Such investigations could be adopted to suit many educational levels of science laboratory activities. (DS)

  3. Costs for hazardous waste incineration: Capital, operation and maintenance, retrofit

    SciTech Connect

    Mc Cormick, R.J.

    1985-01-01

    This book discusses relationships between capital, and O and M costs for hazardous waste incineration and the various waste-specific, design-specific, and operational factors affecting these costs. Selected titles and subtitles: Capital and O and M Maintenance Cost Requirements; Design Assumptions and Engineering Calculations; Capital Cost Estimation; Annual Cost Estimation; Unit Disposal Cost Calculation; Retrofit Cost Relationships Incinerator Systems Considered; and Ionizing Wet Scrubber Costs.

  4. 12 CFR 5.47 - Subordinated debt as capital.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under 12 U.S.C. 1831o and 12 CFR 6.5. (2) Tier 2 capital has the same meaning as set forth in 12 CFR 3.2(d). (3) Tier 3 capital has the same meaning as set forth in 12 CFR part 3, appendix B, section 2(d... debt qualifies as Tier 3 capital if the subordinated debt meets the requirements in 12 CFR part...

  5. 12 CFR 5.47 - Subordinated debt as capital.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... under 12 U.S.C. 1831o and 12 CFR 6.5. (2) Tier 2 capital has the same meaning as set forth in 12 CFR 3.2(d). (3) Tier 3 capital has the same meaning as set forth in 12 CFR part 3, appendix B, section 2(d... debt qualifies as Tier 3 capital if the subordinated debt meets the requirements in 12 CFR part...

  6. 12 CFR 5.47 - Subordinated debt as capital.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... under 12 U.S.C. 1831o and 12 CFR 6.5. (2) Tier 2 capital has the same meaning as set forth in 12 CFR 3.2(d). (3) Tier 3 capital has the same meaning as set forth in 12 CFR part 3, appendix B, section 2(d... debt qualifies as Tier 3 capital if the subordinated debt meets the requirements in 12 CFR part...

  7. 12 CFR 5.47 - Subordinated debt as capital.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... under 12 U.S.C. 1831o and 12 CFR 6.5. (2) Tier 2 capital has the same meaning as set forth in 12 CFR 3.2(d). (3) Tier 3 capital has the same meaning as set forth in 12 CFR part 3, appendix B, section 2(d... debt qualifies as Tier 3 capital if the subordinated debt meets the requirements in 12 CFR part...

  8. 12 CFR 5.47 - Subordinated debt as capital.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... under 12 U.S.C. 1831o and 12 CFR 6.5. (2) Tier 2 capital has the same meaning as set forth in 12 CFR 3.2(d). (3) Tier 3 capital has the same meaning as set forth in 12 CFR part 3, appendix B, section 2(d... debt qualifies as Tier 3 capital if the subordinated debt meets the requirements in 12 CFR part...

  9. Capital Requirements for the Air Transport Industry

    NASA Technical Reports Server (NTRS)

    James, G. W.

    1972-01-01

    In recent years the U.S. scheduled airline industry has been involved in the largest re-equipment program that involves the addition of hundreds of new aircraft to the airline fleet. The costs associated with the purchase of this new equipment, along with the other costs involving such matters as the environment and security, are presenting the carriers with significant financial challenges.

  10. Protein aggregation in salt solutions

    PubMed Central

    Kastelic, Miha; Kalyuzhnyi, Yurij V.; Hribar-Lee, Barbara; Dill, Ken A.; Vlachy, Vojko

    2015-01-01

    Protein aggregation is broadly important in diseases and in formulations of biological drugs. Here, we develop a theoretical model for reversible protein–protein aggregation in salt solutions. We treat proteins as hard spheres having square-well-energy binding sites, using Wertheim’s thermodynamic perturbation theory. The necessary condition required for such modeling to be realistic is that proteins in solution during the experiment remain in their compact form. Within this limitation our model gives accurate liquid–liquid coexistence curves for lysozyme and γ IIIa-crystallin solutions in respective buffers. It provides good fits to the cloud-point curves of lysozyme in buffer–salt mixtures as a function of the type and concentration of salt. It than predicts full coexistence curves, osmotic compressibilities, and second virial coefficients under such conditions. This treatment may also be relevant to protein crystallization. PMID:25964322

  11. 78 FR 13076 - Notice of Submission of Proposed Information Collection to OMB; Border Community Capital Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Border Community... Border Community Capital Initiative grant process. Information is required to rate and rank competitive...: Border Community Capital Initiative. OMB Approval Number: 2506-New. Form Numbers: SF 424;...

  12. Aggregate and the environment

    USGS Publications Warehouse

    Langer, William H.; Drew, Lawrence J.; Sachs, J.S.

    2004-01-01

    This book is designed to help you understand our aggregate resources-their importance, where they come from, how they are processed for our use, the environmental concerns related to their mining and processing, how those concerns are addressed, and the policies and regulations designed to safeguard workers, neighbors, and the environment from the negative impacts of aggregate mining. We hope this understanding will help prepare you to be involved in decisions that need to be made-individually and as a society-to be good stewards of our aggregate resources and our living planet.

  13. Collision simulation of sintered dust aggregates

    NASA Astrophysics Data System (ADS)

    Sirono, Sin-iti; Ueno, Haruta

    Collisional evolution of dust aggregates is the initial process of the planet formation. Sticking velocity, below which collisional sticking of an aggregate happens, is a crucial quantity in the collisional evolution. In the standard model of protoplanetary nebula, the maximum collisional velocity is around 50m/s. Therefore, if a planetesimal is formed through direct collisional sticking, the sticking velocity should be higher than 50m/s. Even if a planetesimal is formed by other mechanism such as anticyclonic vortices, substantial growth of an aggregate is required because the motion of an aggregate should be decoupled from that of gas. Collisional simulation of icy dust aggregates (Wada et al. 2009, ApJ 702, 1490) showed that the sticking velocity was larger than 50m/s and planetesimal formation by collisional sticking was possible. However, sintering of ice proceeds in a wide area of a protoplanetary nebula (Sirono 2011, ApJ 765, 50). Sintering enlarges a neck, connection between adjacent dust grains, and changes the mechanical properties of a dust aggregate. Here we performed collisional simulations between sintered dust aggregates taking account of sintering. We found that the sticking velocity was decreased substantially down to 20m/s. This result suggests that a planetesimal is not formed by direct collisional sticking and that the planetesimal formation proceeded in particular regions in a protoplanetary nebula.

  14. Protein Colloidal Aggregation Project

    NASA Technical Reports Server (NTRS)

    Oliva-Buisson, Yvette J. (Compiler)

    2014-01-01

    To investigate the pathways and kinetics of protein aggregation to allow accurate predictive modeling of the process and evaluation of potential inhibitors to prevalent diseases including cataract formation, chronic traumatic encephalopathy, Alzheimer's Disease, Parkinson's Disease and others.

  15. 7 CFR 3560.563 - Initial operating capital.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Initial operating capital. 3560.563 Section 3560.563 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF... capital. The requirements for § 3560.64 apply to all applications for off-farm labor housing loans...

  16. 7 CFR 3560.563 - Initial operating capital.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Initial operating capital. 3560.563 Section 3560.563 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF... capital. The requirements for § 3560.64 apply to all applications for off-farm labor housing loans...

  17. 12 CFR 163.74 - Mutual capital certificates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... capital requirements under part 167 of this chapter if a Federal savings association or 12 CFR part 390... a Federal savings association or 12 CFR part 390, subpart Z if a state savings association; And... parity with another class of mutual capital certificates; or (F) Action is sought which would...

  18. 12 CFR 163.74 - Mutual capital certificates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... capital requirements under part 167 of this chapter if a Federal savings association or 12 CFR part 390... a Federal savings association or 12 CFR part 390, subpart Z if a state savings association; And... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Mutual capital certificates. 163.74 Section...

  19. Social Capital, Organizational Learning Capability, and Technological Knowledge Transfer

    ERIC Educational Resources Information Center

    Fang, Shih-Chieh; Hung, Richard Yu-Yuan

    2007-01-01

    This study uses inter-organizational networks to focus on firm opportunities to establish the level of social capital required to efficiently utilize network resources among certain collaborative research projects. This study reached the following conclusions: (1) establishment of social capital does little to improve the technological knowledge…

  20. Graduate Inquiry: Social Capital in Online Courses

    ERIC Educational Resources Information Center

    Mays, Thomas

    2016-01-01

    As colleges and universities increase their online course offerings, student social experiences in online learning environments require further examination, specifically for nonresidential students who may already be less integrated into college social networks. A social capital framework was used to guide this qualitative study of 17…

  1. Building Inclusive Communities: A Social Capital Approach

    ERIC Educational Resources Information Center

    Shaklee, Harriet; Laumatia, Laura; Luckey, Brian; Traver, Sue; Nauman, Arlinda; Tifft, Kathee; Liddil, Audrey; Hampton, Carol

    2010-01-01

    Population shifts have changed the face of many Idaho communities, but inclusive relationships among groups can build the social capital required for communities to thrive. University of Idaho Extension developed "Idaho's Journey for Diversity and Human Rights" as a hands-on traveling workshop about past and present issues of human rights and…

  2. A road map for natural capitalism.

    PubMed

    Lovins, A B; Lovins, L H; Hawken, P

    1999-01-01

    No one would run a business without accounting for its capital outlays. Yet most companies overlook one major capital component--the value of the earth's ecosystem services. It is a staggering omission; recent calculations place the value of the earth's total ecosystem services--water storage, atmosphere regulation, climate control, and so on--at $33 trillion a year. Not accounting for those costs has led to waste on a grand scale. But now a few farsighted companies are finding powerful business opportunities in conserving resources on a similarly grand scale. They are embarking on a journey toward "natural capitalism," a journey that comprises four major shifts in business practices. The first stage involves dramatically increasing the productivity of natural resources, stretching them as much as 100 times further than they do today. In the second stage, companies adopt closed-loop production systems that yield no waste or toxicity. The third stage requires a fundamental change of business model--from one of selling products to one of delivering services. For example, a manufacturer would sell lighting services rather than lightbulbs, thus benefitting the seller and customer for developing extremely efficient, durable lightbulbs. The last stage involves reinvesting in natural capital to restore, sustain, and expand the planet's ecosystem. Because natural capitalism is both necessary and profitable, it will sub-sume traditional industrialism, the authors argue, just as industrialism sub-sumed agrarianism. And the companies that are furthest down the road will have the competitive edge. PMID:10387576

  3. Access to capital--a growing concern.

    PubMed

    Carlson, Donald A

    2004-01-01

    Access to capital over the next ten years will be one of the biggest challenges healthcare organizations will face as they strive to remain competitive and serve their communities. Meeting the growing needs for capital will require a disciplined and honest assessment of the capital sources that will be available and the best ways of positioning an organization to maximize their uses. It is incumbent on chief executive officers and other senior leaders to create a disciplined process for allocating capital and conveying how that process will be linked to the organization's strategic plan. All of the credit constituencies "buying" healthcare need to fully understand how the organization is positioning itself for future growth and success, and detailed bond marketing plans need to be implemented well before the actual sale of a new bond issue. Large and small healthcare providers will have sufficient access to capital in the future if investors believe that senior hospital executives have a credible plan and are disciplined enough to execute it. PMID:15641675

  4. Building Family Capital

    ERIC Educational Resources Information Center

    Lamb, Penny

    2007-01-01

    The family is centre stage of many current policy agendas and this is an exciting time to expand the understanding of the wider benefits of learning as a family and in a family. This article aims to open up new discussions and debate on using the concept of "family capital". The author states that as the debate on the social value of learning and…

  5. Manage "Human Capital" Strategically

    ERIC Educational Resources Information Center

    Odden, Allan

    2011-01-01

    To strategically manage human capital in education means restructuring the entire human resource system so that schools not only recruit and retain smart and capable individuals, but also manage them in ways that support the strategic directions of the organization. These management practices must be aligned with a district's education improvement…

  6. Planning for Capital Reinvestment.

    ERIC Educational Resources Information Center

    Biedenweg, Frederick; Weisburg-Swanson, Lynda; Gardner, Catherine

    1998-01-01

    Describes and evaluates four alternatives for planning and budgeting for capital reinvestment for college and university facilities: physical plant auditing; a depreciation-based approach; percentage of current replacement value; and facility subsystem modeling, or life-cycle modeling. Each has advantages and limitations in budgeting for and…

  7. Creating Schools without Capital.

    ERIC Educational Resources Information Center

    Kolke, Mark

    2001-01-01

    A shortage of capital and appropriate education facilities prompted the Edmonton (Alberta) Public Schools to explore creative solutions such as leasing retrofitted facilities to house new academic programs. Landlords generally like school districts, considering them reliable, long-term tenants for hard-to-rent larger buildings. (MLH)

  8. Towards Transnational Academic Capitalism

    ERIC Educational Resources Information Center

    Kauppinen, Ilkka

    2012-01-01

    This paper contributes to current debates on the relationship between globalisation and higher education. The main argument of the paper is that we are currently witnessing transnationalisation of academic capitalism. This argument is illustrated by examining the collaboration between transnational corporations and research universities, and how…

  9. Reggio Social Capital

    ERIC Educational Resources Information Center

    Stejzygier, Aneta

    2009-01-01

    The paper presents the social capital as the essential element of success of the Reggio Emilia preschools known for their unique approach to the early childhood education. The collaborative effort is introduced through examples of the currently ongoing "Reggio Narrates" project of Reggio preschools, the "Dialogue with the Places" and "The…

  10. 12 CFR 652.85 - When to report the risk-based capital level.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... report the risk-based capital level. (a) You must file a risk-based capital report with us each time you determine your risk-based capital level as required by § 652.80. (b) You must also report to us at once if you identify in the interim between quarterly or more frequent reports to us that you are not...

  11. 12 CFR 652.85 - When to report the risk-based capital level.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... report the risk-based capital level. (a) You must file a risk-based capital report with us each time you determine your risk-based capital level as required by § 652.80. (b) You must also report to us at once if you identify in the interim between quarterly or more frequent reports to us that you are not...

  12. 12 CFR 652.85 - When to report the risk-based capital level.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... report the risk-based capital level. (a) You must file a risk-based capital report with us each time you determine your risk-based capital level as required by § 652.80. (b) You must also report to us at once if you identify in the interim between quarterly or more frequent reports to us that you are not...

  13. 12 CFR 652.85 - When to report the risk-based capital level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... report the risk-based capital level. (a) You must file a risk-based capital report with us each time you determine your risk-based capital level as required by § 652.80. (b) You must also report to us at once if you identify in the interim between quarterly or more frequent reports to us that you are not...

  14. 12 CFR 652.80 - When you must determine the risk-based capital level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... your risk-based capital level at any time. (c) If you anticipate entering into any new business... 12 Banks and Banking 6 2010-01-01 2010-01-01 false When you must determine the risk-based capital... AGRICULTURAL MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.80 When...

  15. 12 CFR 652.90 - How to report your risk-based capital determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., including any business policy decisions or other assumptions made in implementing the risk-based capital... 12 Banks and Banking 6 2010-01-01 2010-01-01 false How to report your risk-based capital... AGRICULTURAL MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.90 How...

  16. 12 CFR 652.65 - Risk-based capital stress test.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... You will perform the risk-based capital stress test as described in summary form below and as...) Data requirements. You will use the following data to implement the risk-based capital stress test. (1... capital stress test. (2) You will use Call Report data as the basis for Corporation data over the...

  17. Social capital and mental health: a comparative analysis of four low income countries.

    PubMed

    De Silva, Mary J; Huttly, Sharon R; Harpham, Trudy; Kenward, Michael G

    2007-01-01

    Women and the poor are disproportionately affected by common mental disorders (CMD), and women in low income countries are particularly at risk. Social capital may explain some of the geographical variation in CMD, but the association between social capital and CMD in low income countries has rarely been studied. This paper aims to explore the relationship between individual and ecological measures of social capital and maternal CMD in four low income countries. Cross-sectional data from the Young Lives (YL) study with information across 234 communities in Peru, Ethiopia, Vietnam and Andhra Pradesh (India) were used. The mental health of mothers of one-year-old children (n=6909), and the individual cognitive and structural social capital of all respondents was assessed. Ecological social capital was calculated by aggregating individual responses to the community level. Multi-level modelling was used to explore the association between individual and ecological (community level) social capital and maternal CMD in each of the four countries, adjusting for a wide range of individual and community level confounders. The analysis shows that individual cognitive social capital is associated with reduced odds of CMD across all four countries. The results for structural social capital are more mixed and culturally specific, with some aspects associated with increased odds of CMD. This suggests that structural social capital has context-specific effects and cognitive social capital more universal effects on maternal CMD. PMID:17045716

  18. How venture capital works.

    PubMed

    Zider, B

    1998-01-01

    The popular mythology surrounding the U.S. venture-capital industry derives from a previous era. Venture capitalists who nurtured the computer industry in its infancy were legendary both for their risk taking and for their hands-on operating experience. But today things are different, and separating the myths from the realities is crucial to understanding this important piece of the U.S. economy. Today's venture capitalists are more like conservative bankers than the risk takers of days past. They have carved out a specialized niche in the capital markets, filling a void that other institutions cannot serve. They are the linch-pins in an efficient system for meeting the needs of institutional investors looking for high returns, of entrepreneurs seeking funding, and of investment bankers looking for companies to sell. Venture capitalists must earn a consistently superior return on investments in inherently risky businesses. The myth is that they do so by investing in good ideas and good plans. In reality, they invest in good industries--that is, industries that are more competitively forgiving than the market as a whole. And they structure their deals in a way that minimizes their risk and maximizes their returns. Although many entrepreneurs expect venture capitalists to provide them with sage guidance as well as capital, that expectation is unrealistic. Given a typical portfolio of ten companies and a 2,000-hour work year, a venture capital partner spends on average less than two hours per week on any given company. In addition to analyzing the current venture-capital system, the author offers practical advice to entrepreneurs thinking about venture funding. PMID:10187243

  19. Technology meets aggregate

    SciTech Connect

    Wilson, C.; Swan, C.

    2007-07-01

    New technology carried out at Tufts University and the University of Massachusetts on synthetic lightweight aggregate has created material from various qualities of fly ash from coal-fired power plants for use in different engineered applications. In pilot scale manufacturing tests an 'SLA' containing 80% fly ash and 20% mixed plastic waste from packaging was produced by 'dry blending' mixed plastic with high carbon fly ash. A trial run was completed to produce concrete masonry unit (CMU) blocks at a full-scale facility. It has been shown that SLA can be used as a partial substitution of a traditional stone aggregate in hot asphalt mix. 1 fig., 2 photos.

  20. Intellectual Capital: Comparison and Contrast.

    ERIC Educational Resources Information Center

    Madsen, Susan R.

    2001-01-01

    Suggests that one of the most important keys for improving individual and organizational performance is in developing and strengthening intellectual capital (IC) and explores the similarities and differences between the concepts of intellectual capital, human capital, and knowledge management. Presents four IC characteristics and addresses the…

  1. 76 FR 74631 - Capital Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... (Pillar 2) Related to the Implementation of the Basel II Advanced Capital Framework, 73 FR 44620 (July 31... Owners' Loan Act. See 76 FR 22662, 22665 (April 22, 2011). The Board may extend the capital plan rule's... in extensive dialogue with these non-CCAR firms to communicate its expectations on capital...

  2. 12 CFR 167.6 - Risk-based capital credit risk-weight categories.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Risk-based capital credit risk-weight categories. 167.6 Section 167.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 167.6 Risk-based capital credit risk-weight categories. (a) Risk-weighted assets. Risk-weighted assets...

  3. 12 CFR 167.6 - Risk-based capital credit risk-weight categories.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Risk-based capital credit risk-weight categories. 167.6 Section 167.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 167.6 Risk-based capital credit risk-weight categories. (a) Risk-weighted assets. Risk-weighted assets...

  4. 12 CFR 567.6 - Risk-based capital credit risk-weight categories.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Risk-based capital credit risk-weight categories. 567.6 Section 567.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY CAPITAL Regulatory Capital Requirements § 567.6 Risk-based capital credit risk-weight categories. (a) Risk-weighted assets. Risk-weighted assets...

  5. Sectoral shifts and aggregate unemployment

    SciTech Connect

    Loungani, P.

    1986-01-01

    Some recent research has taken the view that sectoral or industry-specific shocks significantly affect aggregate unemployment by increasing the amount of inter-industry labor reallocation required. The empirical evidence for this view rests on the finding that during the 1950s - and again during the 1970s - there was a positive correlation between aggregate unemployment and the dispersion of employment growth rates. This thesis demonstrates that this correlation arises largely because oil price shocks affect both unemployment and the dispersion of employment growth. Once the dispersion due to oil shocks is accounted for, the residual dispersion in employment has very low explanatory power for unemployment. Since the dispersion index does not measure pure sectoral shifts, an alternate measure of dispersion is developed that serves as a better proxy for the amount of inter-industry labor reallocation required each period. Estimates using this measure suggest that, during the 1950s, temporary increases in the relative price of oil were responsible for generating the observed correlation. On the other hand, sectoral shifts were important during the 1970s; in particular, the 1973 oil price increase has had significant reallocative effects on the economy. This contention is subjected to further tests by looking at the time-series behavior of employment in durable-goods industries and also by following the inter-industry movements of workers over time through the use of panel data.

  6. 12 CFR 966.3 - Leverage limit and credit rating requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... times the total of paid-in capital stock, retained earnings, and reserves (excluding loss reserves and...) The aggregate amount of assets of any Bank may be up to 25 times the total paid-in capital stock... of deposits and capital, do not exceed 11 percent of such total assets. For the purposes of...

  7. Aggregates, broccoli and cauliflower

    NASA Astrophysics Data System (ADS)

    Grey, Francois; Kjems, Jørgen K.

    1989-09-01

    Naturally grown structures with fractal characters like broccoli and cauliflower are discussed and compared with DLA-type aggregates. It is suggested that the branching density can be used to characterize the growth process and an experimental method to determine this parameter is proposed.

  8. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., require compliance with subpart C of this part, affect the same floodplain or wetland, and are currently under review by HUD (or by a responsible entity authorized by 24 CFR part 58), individual or aggregated... FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS Procedures for Making Determinations on...

  9. Harpin Mediates Cell Aggregation in Erwinia chrysanthemi 3937

    PubMed Central

    Yap, Mee-Ngan; Rojas, Clemencia M.; Yang, Ching-Hong; Charkowski, Amy O.

    2006-01-01

    The hypersensitive response elicitor harpin (HrpN) of soft rot pathogen Erwinia chrysanthemi strains 3937 and EC16 is secreted via the type III secretion system and remains cell surface bound. Strain 3937 HrpN is essential for cell aggregation, but the C-terminal one-third of the protein is not required for aggregative activity. PMID:16513758

  10. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from all aggregate batch vent streams in the compliance demonstration required for reactor batch... comply with the mass emission limit for reactor batch process vents. ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Aggregate batch vent stream...

  11. 12 CFR 621.7 - Rule of aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Rule of aggregation. 621.7 Section 621.7 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING AND REPORTING REQUIREMENTS Loan Performance and Valuation Assessment § 621.7 Rule of aggregation. (a) When one loan to a borrower is placed...

  12. Phosphorus recovery from wastewater by struvite crystallization: property of aggregates.

    PubMed

    Ye, Zhilong; Shen, Yin; Ye, Xin; Zhang, Zhaoji; Chen, Shaohua; Shi, Jianwen

    2014-05-01

    Struvite crystallization is a promising method to remove and recover phosphorus from wastewater to ease both the scarcity of phosphorus rock resources and water eutrophication worldwide. To date, although various kinds of reactor systems have been developed, supporting methods are required to control the struvite fines flushing out of the reactors. As an intrinsic property, aggregation is normally disregarded in the struvite crystallization process, although it is the key factor in final particle size and therefore guarantees phosphorus recovery efficiency. The present study developed a method to analyze the characteristics of struvite aggregates using fractal geometry, and the influence of operational parameters on struvite aggregation was evaluated. Due to its typical orthorhombic molecular structure, struvite particles are prone to crystallize into needle or rod shapes, and aggregate at the corners or edges of crystals. The determined fractal dimension (Dpf) of struvite aggregates was 1.52-1.31, with the corresponding range of equivalent diameter (d0.5) at 295.9-85.4 μm. Aggregates formed in relatively low phosphorus concentrations (3.0-5.0 mmol/L) and mildly alkaline conditions (pH 9.0-9.5) displayed relatively compact structures, large aggregate sizes and high aggregation strength. Increasing pH values led to continuous decrease of aggregate sizes, while the variation of Dpf was insignificant. As to the aggregate evolution, fast growth in a short time followed by a long steady stage was observed. PMID:25079629

  13. Photophoretic force on aggregate grains

    NASA Astrophysics Data System (ADS)

    Matthews, Lorin S.; Kimery, Jesse B.; Wurm, Gerhard; de Beule, Caroline; Kuepper, Markus; Hyde, Truell W.

    2016-01-01

    The photophoretic force may impact planetary formation by selectively moving solid particles based on their composition and structure. This generates collision velocities between grains of different sizes and sorts the dust in protoplanetary discs by composition. This numerical simulation studied the photophoretic force acting on fractal dust aggregates of μm-scale radii. Results show that aggregates tend to have greater photophoretic drift velocities than spheres of similar mass or radii, though with a greater spread in the velocity. While the drift velocities of compact aggregates continue to increase as the aggregates grow larger in size, fluffy aggregates have drift velocities which are relatively constant with size. Aggregates formed from an initially polydisperse size distribution of dust grains behave differently from aggregates formed from a monodisperse population, having smaller drift velocities with directions which deviate substantially from the direction of illumination. Results agree with microgravity experiments which show the difference of photophoretic forces with aggregation state.

  14. Proteins aggregation and human diseases

    NASA Astrophysics Data System (ADS)

    Hu, Chin-Kun

    2015-04-01

    Many human diseases and the death of most supercentenarians are related to protein aggregation. Neurodegenerative diseases include Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), frontotemporallobar degeneration, etc. Such diseases are due to progressive loss of structure or function of neurons caused by protein aggregation. For example, AD is considered to be related to aggregation of Aβ40 (peptide with 40 amino acids) and Aβ42 (peptide with 42 amino acids) and HD is considered to be related to aggregation of polyQ (polyglutamine) peptides. In this paper, we briefly review our recent discovery of key factors for protein aggregation. We used a lattice model to study the aggregation rates of proteins and found that the probability for a protein sequence to appear in the conformation of the aggregated state can be used to determine the temperature at which proteins can aggregate most quickly. We used molecular dynamics and simple models of polymer chains to study relaxation and aggregation of proteins under various conditions and found that when the bending-angle dependent and torsion-angle dependent interactions are zero or very small, then protein chains tend to aggregate at lower temperatures. All atom models were used to identify a key peptide chain for the aggregation of insulin chains and to find that two polyQ chains prefer anti-parallel conformation. It is pointed out that in many cases, protein aggregation does not result from protein mis-folding. A potential drug from Chinese medicine was found for Alzheimer's disease.

  15. Net Operating Working Capital, Capital Budgeting, and Cash Budgets: A Teaching Example

    ERIC Educational Resources Information Center

    Tuner, James A.

    2016-01-01

    Many introductory finance texts present information on the capital budgeting process, including estimation of project cash flows. Typically, estimation of project cash flows begins with a calculation of net income. Getting from net income to cash flows requires accounting for non-cash items such as depreciation. Also important is the effect of…

  16. Dynamics of fire ant aggregations

    NASA Astrophysics Data System (ADS)

    Tennenbaum, Michael; Hu, David; Fernandez-Nieves, Alberto

    Fire ant aggregations are an inherently active system. Each ant harvests its own energy and can convert it into motion. The motion of individual ants contributes non-trivially to the bulk material properties of the aggregation. We have measured some of these properties using plate-plate rheology, where the response to an applied external force or deformation is measured. In this talk, we will present data pertaining to the aggregation behavior in the absence of any external force. We quantify the aggregation dynamics by monitoring the rotation of the top plate and by measuring the normal force. We then compare the results with visualizations of 2D aggregations.

  17. 12 strategies for managing capital projects.

    PubMed

    Stoudt, Richard L

    2013-05-01

    To reduce the amount of time and cost associated with capital projects, healthcare leaders should: Begin the project with a clear objective and a concise master facilities plan. Select qualified team members who share the vision of the owner. Base the size of the project on a conservative business plan. Minimize incremental program requirements. Evaluate the cost impact of the building footprint. Consider alternative delivery methods. PMID:23678692

  18. Social Capital Theory and the Metropolitan University: Reframing Ideas about Neighborhood Interactions

    ERIC Educational Resources Information Center

    Plagens, Gregory K.; Stapleton, Kenneth C.

    2011-01-01

    The idea that social relations can aggregate into social capital has intuitive appeal that scholars are finding useful as they seek to explain variations in community outcomes. This article suggests that it may be time for metropolitan university administrators to begin thinking beyond community relations or community engagement as they seek to…

  19. Increased cytoplasm viscosity hampers aggregate polar segregation in Escherichia coli.

    PubMed

    Oliveira, Samuel M D; Neeli-Venkata, Ramakanth; Goncalves, Nadia S M; Santinha, João A; Martins, Leonardo; Tran, Huy; Mäkelä, Jarno; Gupta, Abhishekh; Barandas, Marilia; Häkkinen, Antti; Lloyd-Price, Jason; Fonseca, José M; Ribeiro, Andre S

    2016-02-01

    In Escherichia coli, under optimal conditions, protein aggregates associated with cellular aging are excluded from midcell by the nucleoid. We study the functionality of this process under sub-optimal temperatures from population and time lapse images of individual cells and aggregates and nucleoids within. We show that, as temperature decreases, aggregates become homogeneously distributed and uncorrelated with nucleoid size and location. We present evidence that this is due to increased cytoplasm viscosity, which weakens the anisotropy in aggregate displacements at the nucleoid borders that is responsible for their preference for polar localisation. Next, we show that in plasmolysed cells, which have increased cytoplasm viscosity, aggregates are also not preferentially located at the poles. Finally, we show that the inability of cells with increased viscosity to exclude aggregates from midcell results in enhanced aggregate concentration in between the nucleoids in cells close to dividing. This weakens the asymmetries in aggregate numbers between sister cells of subsequent generations required for rejuvenating cell lineages. We conclude that the process of exclusion of protein aggregates from midcell is not immune to stress conditions affecting the cytoplasm viscosity. The findings contribute to our understanding of E. coli's internal organisation and functioning, and its fragility to stressful conditions. PMID:26507787

  20. Social Capital, Value, and Measure: Antonio Negri's Challenge to Capitalism.

    ERIC Educational Resources Information Center

    Day, Ronald E.

    2002-01-01

    Considers one concept in knowledge management, that of social capital, focusing on the problem of measure and value in capitalism, specifically within the period and conditions of post-Fordist production. Discusses the work of Antonio Negri and suggests the importance of knowledge management as a symptom of a turn in political economy. (Author/LRW)

  1. Making Graphene Resist Aggregation

    NASA Astrophysics Data System (ADS)

    Luo, Jiayan

    Graphene-based sheets have stimulated great interest in many scientific disciplines and shown promise for wide potential applications. Among various ways of creating single atomic layer carbon sheets, a promising route for bulk production is to first chemically exfoliate graphite powders to graphene oxide (GO) sheets, followed by reduction to form chemically modified graphene (CMG). Due to the strong van der Waals attraction between graphene sheets, CMG tends to aggregate. The restacking of sheets is largely uncontrollable and irreversible, thus it reduces their processability and compromises properties such as accessible surface area. Strategies based on colloidal chemistry have been applied to keep CMG dispersed in solvents by introducing electrostatic repulsion to overcome the van der Waals attraction or adding spacers to increase the inter-sheet spacing. In this dissertation, two very different ideas that can prevent CMG aggregation without extensively modifying the material or introducing foreign spacer materials are introduced. The van der Waals potential decreases with reduced overlapping area between sheets. For CMG, reducing the lateral dimension from micrometer to nanometer scale should greatly enhance their colloidal stability with additional advantages of increased charge density and decreased probability to interact. The enhanced colloidal stability of GO and CMG nanocolloids makes them especially promising for spectroscopy based bio-sensing applications. For potential applications in a compact bulk solid form, the sheets were converted into paper-ball like structure using capillary compression in evaporating aerosol droplets. The crumpled graphene balls are stabilized by locally folded pi-pi stacked ridges, and do not unfold or collapse during common processing steps. They can tightly pack without greatly reducing the surface area. This form of graphene leads to scalable performance in energy storage. For example, planer sheets tend to aggregate and

  2. Structure of Viral Aggregates

    NASA Astrophysics Data System (ADS)

    Barr, Stephen; Luijten, Erik

    2010-03-01

    The aggregation of virus particles is a particular form of colloidal self-assembly, since viruses of a give type are monodisperse and have identical, anisotropic surface charge distributions. In small-angle X-ray scattering experiments, the Qbeta virus was found to organize in different crystal structures in the presence of divalent salt and non-adsorbing polymer. Since a simple isotropic potential cannot explain the occurrence of all observed phases, we employ computer simulations to investigate how the surface charge distribution affects the virus interactions. Using a detailed model of the virus particle, we find an asymmetric ion distribution around the virus which gives rise to the different phases observed.

  3. Taurine and platelet aggregation

    SciTech Connect

    Nauss-Karol, C.; VanderWende, C.; Gaut, Z.N.

    1986-03-01

    Taurine is a putative neurotransmitter or neuromodulator. The endogenous taurine concentration in human platelets, determined by amino acid analysis, is 15 ..mu..M/g. In spite of this high level, taurine is actively accumulated. Uptake is saturable, Na/sup +/ and temperature dependent, and suppressed by metabolic inhibitors, structural analogues, and several classes of centrally active substances. High, medium and low affinity transport processes have been characterized, and the platelet may represent a model system for taurine transport in the CNS. When platelets were incubated with /sup 14/C-taurine for 30 minutes, then resuspended in fresh medium and reincubated for one hour, essentially all of the taurine was retained within the cells. Taurine, at concentrations ranging from 10-1000 ..mu..M, had no effect on platelet aggregation induced by ADP or epinephrine. However, taurine may have a role in platelet aggregation since 35-39% of the taurine taken up by human platelets appears to be secreted during the release reaction induced by low concentrations of either epinephrine or ADP, respectively. This release phenomenon would imply that part of the taurine taken up is stored directly in the dense bodies of the platelet.

  4. Dielectric approach to investigation of erythrocyte aggregation. II. Kinetics of erythrocyte aggregation-disaggregation in quiescent and flowing blood.

    PubMed

    Pribush, A; Meiselman, H J; Meyerstein, D; Meyerstein, N

    2000-01-01

    A method based on dielectric properties of dispersed systems was applied to investigate the kinetics of RBC aggregation and the break-up of the aggregates. Experimentally, this method consists of measuring the capacitance at a frequency in the beginning of the beta-dispersion. Two experimental protocols were used to investigate the aggregation process. In the first case, blood samples were fully dispersed and then the flow was decreased or stopped to promote RBC aggregation. It was found that the initial phases of RBC aggregation are not affected by the shear rate. This finding indicates that RBC aggregation is a slow coagulation process. In the second case, RBCs aggregated under flow conditions at different shear rates and after the capacitance reached plateau levels, the flow was ceased. The steady-state capacitance of the quiescent blood and the kinetics of RBC aggregation after stoppage of shearing depend on the prior shear rate. To clarify the reasons for this effect, the kinetics of the disaggregation process was studied. In these experiments, time courses of the capacitance were recorded under different flow conditions and then a higher shear stress was applied to break up RBC aggregates. It was found that the kinetics of the disaggregation process depend on both the prior and current shear stresses. Results obtained in this study and their analysis show that the kinetics of RBC aggregation in stasis consists of two consecutive phases: At the onset, red blood cells interact face-to-face to form linear aggregates and then, after an accumulation of an appropriate concentration of these aggregates, branched rouleaux are formed via reactions of ends of the linear rouleaux with sides of other rouleaux (face-to-side interactions). Branching points are broken by low shear stresses whereas dispersion of the linear rouleaux requires significantly higher energy. PMID:11204548

  5. 12 CFR 565.4 - Capital measures and capital category definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Capital measures and capital category... PROMPT CORRECTIVE ACTION § 565.4 Capital measures and capital category definitions. (a) Capital measures. For purposes of section 38 and this part, the relevant capital measures shall be: (1) The total...

  6. Schools, Social Capital and Space

    ERIC Educational Resources Information Center

    Allan, Julie; Catts, Ralph

    2014-01-01

    This paper reports on the significance of social capital in relation to education, exploring its relevance to teachers and other professionals as well as among young people. It draws on aspects of five case studies undertaken by the Schools and Social Capital Network, within the Applied Educational Research Scheme in Scotland. These case studies…

  7. Universities Venture into Venture Capitalism.

    ERIC Educational Resources Information Center

    Desruisseaux, Paul

    2000-01-01

    Reports that some universities are starting their own venture-capital funds to develop campus companies, or are investing endowment funds with established venture-capital firms inclined to finance potential spinoffs from campus research. Examples cited are from the University of Alabama, Vanderbilt University (Tennessee), University of…

  8. Capital planning: investing in excellence.

    PubMed

    Slater, G; Del Bravo, K

    1994-04-01

    Graham Slater and Kate Del Bravo describe the priorities considered and work undertaken by SETRHA to develop its capital investment strategy. Although the underlying concepts are straightforward, it represents a significant development beyond traditional NHS approaches to planning, embraces the NHS market reforms, and has reduced capital aspirations for the same service objectives by some 300m pounds. PMID:10137118

  9. Transformative Pedagogy for Social Capital

    ERIC Educational Resources Information Center

    Willis, Peter

    2007-01-01

    This paper explores ways in which pedagogy for an elaborated form of transformative learning can be a useful catalyst for the development of social capital in community and workplace groups and networks. I begin with an example and then explore ideas of learning challenges embedded in building and maintaining social capital. I consider the…

  10. Rethinking Higher Education Capital Finance.

    ERIC Educational Resources Information Center

    King, George A.

    1988-01-01

    Capital finance in institutions of higher education is analyzed in light of changes in the Tax Reform Act of 1986 affecting the ability of institutions to finance capital projects and the likelihood of changes in the government's view of tax-exempt financing. The options for colleges and universities are analyzed in the following areas: (1)…

  11. Low workplace social capital as a predictor of depression: the Finnish Public Sector Study.

    PubMed

    Kouvonen, Anne; Oksanen, Tuula; Vahtera, Jussi; Stafford, Mai; Wilkinson, Richard; Schneider, Justine; Väänänen, Ari; Virtanen, Marianna; Cox, Sara J; Pentti, Jaana; Elovainio, Marko; Kivimäki, Mika

    2008-05-15

    In a prospective cohort study of Finnish public sector employees, the authors examined the association between workplace social capital and depression. Data were obtained from 33,577 employees, who had no recent history of antidepressant treatment and who reported no history of physician-diagnosed depression at baseline in 2000-2002. Their risk of depression was measured with two indicators: recorded purchases of antidepressants until December 31, 2005, and self-reports of new-onset depression diagnosed by a physician in the follow-up survey in 2004-2005. Multilevel logistic regression analysis was used to explore whether self-reported and aggregate-level workplace social capital predicted indicators of depression at follow-up. The odds for antidepressant treatment and physician-diagnosed depression were 20-50% higher for employees with low self-reported social capital than for those reporting high social capital. These associations were not accounted for by sex, age, marital status, socioeconomic position, place of work, smoking, alcohol use, physical activity, and body mass index. The association between social capital and self-reported depression attenuated but remained significant after further adjustment for baseline psychological distress (a proxy for undiagnosed mental health problems). Aggregate-level social capital was not associated with subsequent depression. PMID:18413361

  12. capital planning for a new era.

    PubMed

    Hegwer, Laura Ramos

    2016-05-01

    Capital planning has become more centralized at many health systems. Managing the capital budget for IT continues to be a challenge. The arrival of value-based payment is influencing some organizations' strategic capital investments. PMID:27382709

  13. Aggregation dynamics of rigid polyelectrolytes

    NASA Astrophysics Data System (ADS)

    Tom, Anvy Moly; Rajesh, R.; Vemparala, Satyavani

    2016-01-01

    Similarly charged polyelectrolytes are known to attract each other and aggregate into bundles when the charge density of the polymers exceeds a critical value that depends on the valency of the counterions. The dynamics of aggregation of such rigid polyelectrolytes are studied using large scale molecular dynamics simulations. We find that the morphology of the aggregates depends on the value of the charge density of the polymers. For values close to the critical value, the shape of the aggregates is cylindrical with height equal to the length of a single polyelectrolyte chain. However, for larger values of charge, the linear extent of the aggregates increases as more and more polymers aggregate. In both the cases, we show that the number of aggregates decrease with time as power laws with exponents that are not numerically distinguishable from each other and are independent of charge density of the polymers, valency of the counterions, density, and length of the polyelectrolyte chain. We model the aggregation dynamics using the Smoluchowski coagulation equation with kernels determined from the molecular dynamics simulations and justify the numerically obtained value of the exponent. Our results suggest that once counterions condense, effective interactions between polyelectrolyte chains short-ranged and the aggregation of polyelectrolytes are diffusion-limited.

  14. 78 FR 62417 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... comments that appeared in the Federal Register of September 10, 2013 (78 FR 55340), regarding Regulatory... NW., Washington, DC 20429. SUPPLEMENTARY INFORMATION: In FR Doc. 2013-21357, appearing on page 55518... Part 324 RIN 3064-AD95 Regulatory Capital Rules: Regulatory Capital, Implementation of Basel...

  15. 75 FR 4635 - Risk-Based Capital Guidelines; Capital Adequacy Guidelines; Capital Maintenance: Regulatory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ...-in of the regulatory capital effects of the accounting changes, among other issues.\\9\\ \\9\\ 74 FR... Capital; Impact of Modifications to Generally Accepted Accounting Principles; Consolidation of Asset... Accounting Principles; Consolidation of Asset-Backed Commercial Paper Programs; and Other Related...

  16. Scalable evaluation of platelet aggregation by the degree of blood migration

    NASA Astrophysics Data System (ADS)

    Song, Suk-Heung; Lim, Chae-Seung; Shin, Sehyun

    2013-12-01

    Platelet aggregation plays a key role in vascular thrombosis. Antiplatelet drug therapy is commonly used for the prevention of abnormal platelet aggregation. So, measuring platelet aggregation function is critically important in clinical field. Here, we introduce a scalable evaluation method of platelet aggregation measured with the degree of blood migration through microchannel in a microfluidic chip. Unlike conventional methods that require expertise with system physics to operate devices, our approach is using microfluidics system, which requires only a syringe vacuum. The scalable migration factors, migration distance and touchdown time, are capable of distinguishing various antiplatelet drug effects under microfluidics and would be effective for the quick and easy evaluation of quantitative platelet aggregation.

  17. Implications of epidermal growth factor (EGF) induced egf receptor aggregation.

    PubMed Central

    Wofsy, C; Goldstein, B; Lund, K; Wiley, H S

    1992-01-01

    To investigate the role of receptor aggregation in EGF binding, we construct a mathematical model describing receptor dimerization (and higher levels of aggregation) that permits an analysis of the influence of receptor aggregation on ligand binding. We answer two questions: (a) Can Scatchard plots of EGF binding data be analyzed productively in terms of two noninteracting receptor populations with different affinities if EGF induced receptor aggregation occurs? No. If two affinities characterize aggregated and monomeric EGF receptors, we show that the Scatchard plot should have curvature characteristic of positively cooperative binding, the opposite of that observed. Thus, the interpretation that the high affinity population represents aggregated receptors and the low affinity population nonaggregated receptors is wrong. If the two populations are interpreted without reference to receptor aggregation, an important determinant of Scatchard plot shape is ignored. (b) Can a model for EGF receptor aggregation and EGF binding be consistent with the "negative curvature" (i.e., curvature characteristic of negatively cooperative binding) observed in most Scatchard plots of EGF binding data? Yes. In addition, the restrictions on the model parameters required to obtain negatively curved Scatchard plots provide new information about binding and aggregation. In particular, EGF binding to aggregated receptors must be negatively cooperative, i.e., binding to a receptor in a dimer (or higher oligomer) having one receptor already bound occurs with lower affinity than the initial binding event. A third question we consider is whether the model we present can be used to detect the presence of mechanisms other than receptor aggregation that are contributing to Scatchard plot curvature. For the membrane and cell binding data we analyzed, the best least squares fits of the model to each of the four data sets deviate systematically from the data, indicating that additional factors are

  18. IgG Conformer's Binding to Amyloidogenic Aggregates

    PubMed Central

    Phay, Monichan; Welzel, Alfred T.; Williams, Angela D.; McWilliams-Koeppen, Helen P.; Blinder, Veronika; O'Malley, Tiernan T.; Solomon, Alan; Walsh, Dominic M.; O'Nuallain, Brian

    2015-01-01

    Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findings on pAb conformer's binding to amyloidogenic aggregates: 1) pAb aggregates have greater activity than monomers (HMW species > dimers > monomers), 2) pAbs interactions with amyloidogenic aggregates at least partially involves unconventional (non-CDR) interactions of F(ab) regions, and 3) pAb's activity can be easily modulated by trace aggregates generated during sample processing. Specifically, we show that HMW aggregates and dimeric pAbs present in commercial preparations of pAbs, intravenous immunoglobulin (IVIg), had up to ~200- and ~7-fold stronger binding to aggregates of Aβ and transthyretin (TTR) than the monomeric antibody. Notably, HMW aggregates were primarily responsible for the enhanced anti-amyloid activities of Aβ- and Cibacron blue-isolated IVIg IgGs. Human pAb conformer's binding to amyloidogenic aggregates was retained in normal human sera, and mimicked by murine pAbs isolated from normal pooled plasmas. An unconventional (non-CDR) component to pAb's activity was indicated from control human mAbs, generated against non-amyloid targets, binding to aggregated Aβ and TTR. Similar to pAbs, HMW and dimeric mAb conformers bound stronger than their monomeric forms to amyloidogenic aggregates. However, mAbs had lower maximum binding signals, indicating that pAbs were required to saturate a diverse collection of binding sites. Taken together, our findings strongly support further investigations on the physiological function and clinical utility of the inherent anti-amyloid activities of monomeric but not aggregated IgGs. PMID:26367058

  19. 12 CFR 3.22 - Regulatory capital adjustments and deductions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements set forth at 12 CFR part 3 (OCC); 12 CFR part 225 (Board); 12 CFR part 325, and 12 CFR part 390... 18 These rules include the regulatory capital requirements set forth at 12 CFR part 3 (OCC); 12 CFR part 225 (Board); 12 CFR part 325, and 12 CFR part 390 (FDIC). (B) Prior to the merger, acquisition,...

  20. Aggregating Hierarchical Service Level Agreements in Business Value Networks

    NASA Astrophysics Data System (ADS)

    Ul Haq, Irfan; Huqqani, Altaf; Schikuta, Erich

    Business scenarios such as Business Value Networks and Extended Enterprises pose new challenges for service choreographies across heterogeneous Virtual Organizations. In such scenarios, services compose together hierarchically in a producer-consumer manner to form service supply-chains of added value. Service Level Agreements (SLAs) are defined at various levels in this hierarchy to ensure the expected quality of service for different stakeholders. Automation of service composition directly implies the aggregation of their corresponding SLAs. But so far, the aggregation of SLAs has been treated only as a single layer process which is insufficient to complement the hierarchical aggregation of services. In this paper we elaborate on the requirement of a hierarchical aggregation of SLAs corresponding to service choreographies in Business Value Networks. During the hierarchical aggregation of SLAs, certain SLA information pertaining to different stakeholders is meant to be restricted and can be only partially revealed to a subset of their business partners. We introduce the concept of SLA-Views to protect such privacy concerns. We, then formalize the notion of SLA Choreography and define an aggregation model based on SLA-Views to enable the automation of hierarchical aggregation of Service Level Agreements. The aggregation model has been designed to comply with the WS-Agreement standard.

  1. Giving means receiving: the protective effect of social capital on binge drinking on college campuses.

    PubMed Central

    Weitzman, E R; Kawachi, I

    2000-01-01

    OBJECTIVES: We tested whether higher levels of social capital on college campuses protected against individual risks of binge drinking. METHODS: We used a nationally representative survey of 17,592 young people enrolled at 140 4-year colleges. Social capital was operationalized as individuals' average time committed to volunteering in the past month aggregated to the campus level. RESULTS: In multivariate analyses controlling for individual volunteering, sociodemographics, and several college characteristics, individuals from campuses with higher-than-average levels of social capital had a 26% lower individual risk for binge drinking (P < .001) than their peers at other schools. CONCLUSIONS: Social capital may play an important role in preventing binge drinking in the college setting. PMID:11111272

  2. Control of binder viscosity and hygroscopicity on particle aggregation efficiency

    NASA Astrophysics Data System (ADS)

    Mueller, Sebastian B.; Kueppers, Ulrich; Ayris, Paul M.; Jacob, Michael; Delmelle, Pierre; Dingwell, Donald B.

    2016-04-01

    In the course of explosive volcanic eruptions, large amounts of ash are released into the atmosphere and may subsequently pose a threat to infrastructure, such as aviation industry. Ash plume forecasting is therefore a crucial tool for volcanic hazard mitigation but may be significantly affected by aggregation, altering the aerodynamic properties of particles. Models struggle with the implementation of aggregation since external conditions promoting aggregation have not been completely understood; in a previous study we have shown the rapid generation of ash aggregates through liquid bonding via the use of fluidization bed technology and further defined humidity and temperature ranges necessary to trigger aggregation. Salt (NaCl) was required for the recovery of stable aggregates, acting as a cementation agent and granting aggregate cohesion. A numerical model was used to explain the physics behind particle aggregation mechanisms and further predicted a dependency of aggregation efficiency on liquid binder viscosity. In this study we proof the effect of viscosity on particle aggregation. HCl and H2SO4 solutions were diluted to various concentrations resulting in viscosities between 1 and 2 mPas. Phonolitic and rhyolitic ash samples as well as soda-lime glass beads (serving as analogue material) were fluidized in the ProCell Lab® of Glatt Ingenieurtechnik GmbH and treated with the acids via a bottom-spray technique. Chemically driven interaction between acid liquids and surfaces of the three used materials led to crystal precipitation. Salt crystals (e.g. NaCl) have been confirmed through scanning electron microscopy (SEM) and leachate analysis. Both volcanic ash samples as well as the glass beads showed a clear dependency of aggregation efficiency on viscosity of the sprayed HCl solution. Spraying H2SO4 provoked a collapse of the fluidized bed and no aggregation has been observed. This is accounted by the high hygroscopicity of H2SO4. Dissolving CaCl2 (known to be

  3. Electric power substation capital costs

    SciTech Connect

    Dagle, J.E.; Brown, D.R.

    1997-12-01

    The displacement or deferral of substation equipment is a key benefit associated with several technologies that are being developed with the support of the US Department of Energy`s Office of Utility Technologies. This could occur, for example, as a result of installing a distributed generating resource within an electricity distribution system. The objective of this study was to develop a model for preparing preliminary estimates of substation capital costs based on rudimentary conceptual design information. The model is intended to be used by energy systems analysts who need ``ballpark`` substation cost estimates to help establish the value of advanced utility technologies that result in the deferral or displacement of substation equipment. This cost-estimating model requires only minimal inputs. More detailed cost-estimating approaches are recommended when more detailed design information is available. The model was developed by collecting and evaluating approximately 20 sets of substation design and cost data from about 10 US sources, including federal power marketing agencies and private and public electric utilities. The model is principally based on data provided by one of these sources. Estimates prepared with the model were compared with estimated and actual costs for the data sets received from the other utilities. In general, good agreement (for conceptual level estimating) was found between estimates prepared with the cost-estimating model and those prepared by the individual utilities. Thus, the model was judged to be adequate for making preliminary estimates of typical substation costs for US utilities.

  4. Peptide aggregation in neurodegenerative disease.

    PubMed

    Murphy, Regina M

    2002-01-01

    In the not-so-distant past, insoluble aggregated protein was considered as uninteresting and bothersome as yesterday's trash. More recently, protein aggregates have enjoyed considerable scientific interest, as it has become clear that these aggregates play key roles in many diseases. In this review, we focus attention on three polypeptides: beta-amyloid, prion, and huntingtin, which are linked to three feared neurodegenerative diseases: Alzheimer's, "mad cow," and Huntington's disease, respectively. These proteins lack any significant primary sequence homology, yet their aggregates possess very similar features, specifically, high beta-sheet content, fibrillar morphology, relative insolubility, and protease resistance. Because the aggregates are noncrystalline, secrets of their structure at nanometer resolution are only slowly yielding to X-ray diffraction, solid-state NMR, and other techniques. Besides structure, the aggregates may possess similar pathways of assembly. Two alternative assembly pathways have been proposed: the nucleation-elongation and the template-assisted mode. These two modes may be complementary, not mutually exclusive. Strategies for interfering with aggregation, which may provide novel therapeutic approaches, are under development. The structural similarities between protein aggregates of dissimilar origin suggest that therapeutic strategies successful against one disease may have broad utility in others. PMID:12117755

  5. Topics in Probabilistic Judgment Aggregation

    ERIC Educational Resources Information Center

    Wang, Guanchun

    2011-01-01

    This dissertation is a compilation of several studies that are united by their relevance to probabilistic judgment aggregation. In the face of complex and uncertain events, panels of judges are frequently consulted to provide probabilistic forecasts, and aggregation of such estimates in groups often yield better results than could have been made…

  6. Mineral of the month: aggregates

    USGS Publications Warehouse

    Tepordei, Valentin V.

    2005-01-01

    Natural aggregates, consisting of crushed stone, and sand and gravel, are a major contributor to economic health, and have an amazing variety of uses. Aggregates are among the most abundant mineral resources and are major basic raw materials used by construction, agriculture and other industries that employ complex chemical and metallurgical processes.

  7. Mechanics of fire ant aggregations

    NASA Astrophysics Data System (ADS)

    Tennenbaum, Michael; Liu, Zhongyang; Hu, David; Fernandez-Nieves, Alberto

    2016-01-01

    Fire ants link their bodies to form aggregations; these can adopt a variety of structures, they can drip and spread, or withstand applied loads. Here, by using oscillatory rheology, we show that fire ant aggregations are viscoelastic. We find that, at the lowest ant densities probed and in the linear regime, the elastic and viscous moduli are essentially identical over the spanned frequency range, which highlights the absence of a dominant mode of structural relaxation. As ant density increases, the elastic modulus rises, which we interpret by alluding to ant crowding and subsequent jamming. When deformed beyond the linear regime, the aggregation flows, exhibiting shear-thinning behaviour with a stress load that is comparable to the maximum load the aggregation can withstand before individual ants are torn apart. Our findings illustrate the rich, collective mechanical behaviour that can arise in aggregations of active, interacting building blocks.

  8. Mechanics of fire ant aggregations.

    PubMed

    Tennenbaum, Michael; Liu, Zhongyang; Hu, David; Fernandez-Nieves, Alberto

    2016-01-01

    Fire ants link their bodies to form aggregations; these can adopt a variety of structures, they can drip and spread, or withstand applied loads. Here, by using oscillatory rheology, we show that fire ant aggregations are viscoelastic. We find that, at the lowest ant densities probed and in the linear regime, the elastic and viscous moduli are essentially identical over the spanned frequency range, which highlights the absence of a dominant mode of structural relaxation. As ant density increases, the elastic modulus rises, which we interpret by alluding to ant crowding and subsequent jamming. When deformed beyond the linear regime, the aggregation flows, exhibiting shear-thinning behaviour with a stress load that is comparable to the maximum load the aggregation can withstand before individual ants are torn apart. Our findings illustrate the rich, collective mechanical behaviour that can arise in aggregations of active, interacting building blocks. PMID:26501413

  9. Molecular aggregation of humic substances

    USGS Publications Warehouse

    Wershaw, R. L.

    1999-01-01

    Humic substances (HS) form molecular aggregates in solution and on mineral surfaces. Elucidation of the mechanism of formation of these aggregates is important for an understanding of the interactions of HS in soils arid natural waters. The HS are formed mainly by enzymatic depolymerization and oxidation of plant biopolymers. These reactions transform the aromatic and lipid plant components into amphiphilic molecules, that is, molecules that consist of separate hydrophobic (nonpolar) and hydrophilic (polar) parts. The nonpolar parts of the molecules are composed of relatively unaltered segments of plant polymers and the polar parts of carboxylic acid groups. These amphiphiles form membrane-like aggregates on mineral surfaces and micelle-like aggregates in solution. The exterior surfaces of these aggregates are hydrophilic, and the interiors constitute separate hydrophobic liquid-like phases.

  10. Imbibition kinetics of spherical aggregates

    NASA Astrophysics Data System (ADS)

    Hébraud, Pascal; Lootens, Didier; Debacker, Alban

    The imbibition kinetics of a millimeter-sized aggregate of 300 nm diameter colloidal particles by a wetting pure solvent is studied. Three successive regimes are observed : in the first one, the imbibition proceeds by compressing the air inside the aggregate. Then, the solvent stops when the pressure of the compressed air is equal to the Laplace pressure at the meniscus of the wetting solvent in the porous aggregate. The interface is pinned and the aggregate slowly degases, up to a point where the pressure of the entrapped air stops decreasing and is controlled by the Laplace pressure of small bubbles. Depending on the curvature of the bubble, the system may then be in an unstable state. The imbibition then starts again, but with an inner pressure in equilibrium with these bubbles. This last stage leads to the complete infiltration of the aggregate.

  11. Immunogenicity of Therapeutic Protein Aggregates.

    PubMed

    Moussa, Ehab M; Panchal, Jainik P; Moorthy, Balakrishnan S; Blum, Janice S; Joubert, Marisa K; Narhi, Linda O; Topp, Elizabeth M

    2016-02-01

    Therapeutic proteins have a propensity for aggregation during manufacturing, shipping, and storage. The presence of aggregates in protein drug products can induce adverse immune responses in patients that may affect safety and efficacy, and so it is of concern to both manufacturers and regulatory agencies. In this vein, there is a lack of understanding of the physicochemical determinants of immunological responses and a lack of standardized analytical methods to survey the molecular properties of aggregates associated with immune activation. In this review, we provide an overview of the basic immune mechanisms in the context of interactions with protein aggregates. We then critically examine the literature with emphasis on the underlying immune mechanisms as they relate to aggregate properties. Finally, we highlight the gaps in our current understanding of this issue and offer recommendations for future research. PMID:26869409

  12. Practical problems in aggregating expert opinions

    SciTech Connect

    Booker, J.M.; Picard, R.R.; Meyer, M.A.

    1993-11-01

    Expert opinion is data given by a qualified person in response to a technical question. In these analyses, expert opinion provides information where other data are either sparse or non-existent. Improvements in forecasting result from the advantageous addition of expert opinion to observed data in many areas, such as meteorology and econometrics. More generally, analyses of large, complex systems often involve experts on various components of the system supplying input to a decision process; applications include such wide-ranging areas as nuclear reactor safety, management science, and seismology. For large or complex applications, no single expert may be knowledgeable enough about the entire application. In other problems, decision makers may find it comforting that a consensus or aggregation of opinions is usually better than a single opinion. Many risk and reliability studies require a single estimate for modeling, analysis, reporting, and decision making purposes. For problems with large uncertainties, the strategy of combining as diverse a set of experts as possible hedges against underestimation of that uncertainty. Decision makers are frequently faced with the task of selecting the experts and combining their opinions. However, the aggregation is often the responsibility of an analyst. Whether the decision maker or the analyst does the aggregation, the input for it, such as providing weights for experts or estimating other parameters, is imperfect owing to a lack of omniscience. Aggregation methods for expert opinions have existed for over thirty years; yet many of the difficulties with their use remain unresolved. The bulk of these problem areas are summarized in the sections that follow: sensitivities of results to assumptions, weights for experts, correlation of experts, and handling uncertainties. The purpose of this paper is to discuss the sources of these problems and describe their effects on aggregation.

  13. 76 FR 9057 - Capital International, Inc., et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... COMMISSION Capital International, Inc., et al.; Notice of Application February 10, 2011. AGENCY: Securities...'') formed for the benefit of eligible employees of Capital International, Inc. (``Capital'') and its.... (``CGPE V''), Capital International Investments IV, LLC (``CII IV''), Capital International Investments...

  14. 12 CFR Appendix A to Subpart B of... - Risk-Based Capital Stress Test

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Risk-Based Capital Stress Test A Appendix A to... MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements Pt. 652, Subpt. B, App. A Appendix A to Subpart B of Part 652— Risk-Based Capital Stress Test 1.0Introduction. 2.0Credit Risk....

  15. Perspectives on Preference Aggregation.

    PubMed

    Regenwetter, Michel

    2009-07-01

    For centuries, the mathematical aggregation of preferences by groups, organizations, or society itself has received keen interdisciplinary attention. Extensive theoretical work in economics and political science throughout the second half of the 20th century has highlighted the idea that competing notions of rational social choice intrinsically contradict each other. This has led some researchers to consider coherent democratic decision making to be a mathematical impossibility. Recent empirical work in psychology qualifies that view. This nontechnical review sketches a quantitative research paradigm for the behavioral investigation of mathematical social choice rules on real ballots, experimental choices, or attitudinal survey data. The article poses a series of open questions. Some classical work sometimes makes assumptions about voter preferences that are descriptively invalid. Do such technical assumptions lead the theory astray? How can empirical work inform the formulation of meaningful theoretical primitives? Classical "impossibility results" leverage the fact that certain desirable mathematical properties logically cannot hold in all conceivable electorates. Do these properties nonetheless hold true in empirical distributions of preferences? Will future behavioral analyses continue to contradict the expectations of established theory? Under what conditions do competing consensus methods yield identical outcomes and why do they do so? PMID:26158988

  16. Social capital and dental pain in Brazilian northeast: a multilevel cross-sectional study

    PubMed Central

    2013-01-01

    Background There is limited evidence on possible associations between social determinants and dental pain. This study investigated the relationship of neighborhood and individual social capital with dental pain in adolescents, adults and the elderly. Methods A population-based multilevel study was conducted involving 624 subjects from 3 age groups: 15–19, 35–44 and 65–74 years. They were randomly selected from 30 census tracts in three cities in the State of Paraíba, Brazil. A two-stage cluster sampling was used considering census tracts and households as sampling units. The outcome of study was the presence of dental pain in the last 6 months. Information on dental pain, demographic, socio-economic, health-related behaviors, use of dental services, self-perceived oral health and social capital measures was collected through interviews. Participants underwent a clinical examination for assessment of dental caries. Neighborhood social capital was evaluated using aggregated measures of social trust, social control, empowerment, political efficacy and neighborhood safety. Individual social capital assessment included bonding and bridging social capital. Multilevel logistic regression was used to test the relationship of neighborhood and individual social capital with dental pain after sequential adjustment for covariates. Results Individuals living in neighborhoods with high social capital were 52% less likely to report dental pain than those living in neighborhoods with low social capital (OR = 0.48, 95% CI = 0.27-0.85). Bonding social capital (positive interaction) was independently associated with dental pain (OR = 0.88, 95% CI = 0.80-0.91). Last dental visit, self-perceived oral health and number of decayed teeth were also significantly associated with dental pain. Conclusions Our findings suggest that contextual and individual social capital are independently associated with dental pain. PMID:23289932

  17. Translationally optimal codons associate with aggregation-prone sites in proteins.

    PubMed

    Lee, Yaelim; Zhou, Tong; Tartaglia, Gian Gaetano; Vendruscolo, Michele; Wilke, Claus O

    2010-12-01

    We analyze the relationship between codon usage bias and residue aggregation propensity in the genomes of four model organisms, Escherichia coli, yeast, fly, and mouse, as well as the archaeon Halobacterium species NRC-1. Using the Mantel-Haenszel procedure, we find that translationally optimal codons associate with aggregation-prone residues. Our results are qualitatively and quantitatively similar to those of an earlier study where we found an association between translationally optimal codons and buried residues. We also combine the aggregation-propensity data with solvent-accessibility data. Although the resulting data set is small, and hence statistical power low, results indicate that the association between optimal codons and aggregation-prone residues exists both at buried and at exposed sites. By comparing codon usage at different combinations of sites (exposed, aggregation-prone sites versus buried, non-aggregation-prone sites; buried, aggregation-prone sites versus exposed, non-aggregation-prone sites), we find that aggregation propensity and solvent accessibility seem to have independent effects of (on average) comparable magnitude on codon usage. Finally, in fly, we assess whether optimal codons associate with sites at which amino acid substitutions lead to an increase in aggregation propensity, and find only a very weak effect. These results suggest that optimal codons may be required to reduce the frequency of translation errors at aggregation-prone sites that coincide with certain functional sites, such as protein-protein interfaces. Alternatively, optimal codons may be required for rapid translation of aggregation-prone regions. PMID:21046618

  18. 47 CFR 65.304 - Capital structure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Capital structure. 65.304 Section 65.304... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.304 Capital structure. The proportion of each cost of capital component in the capital structure is equal to: Proportion in the...

  19. 47 CFR 65.304 - Capital structure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Capital structure. 65.304 Section 65.304... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.304 Capital structure. The proportion of each cost of capital component in the capital structure is equal to: Proportion in the...

  20. 12 CFR 1777.20 - Capital classifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Capital classifications. 1777.20 Section 1777... DEVELOPMENT SAFETY AND SOUNDNESS PROMPT CORRECTIVE ACTION Capital Classifications and Orders Under Section 1366 of the 1992 Act § 1777.20 Capital classifications. (a) Capital classifications after the...

  1. 47 CFR 32.4540 - Other capital.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Other capital. 32.4540 Section 32.4540... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.4540 Other capital. This... capital stock, capital recorded upon the reorganization or recapitalization of the company and...

  2. 47 CFR 32.4540 - Other capital.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Other capital. 32.4540 Section 32.4540... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.4540 Other capital. This... capital stock, capital recorded upon the reorganization or recapitalization of the company and...

  3. 12 CFR 725.5 - Capital stock.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Capital stock. 725.5 Section 725.5 Banks and... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.5 Capital stock. (a) The capital stock of the Facility is divided... or hypothecated except to the Facility. (b) The capital stock subscriptions provided for in §§...

  4. 12 CFR 1777.20 - Capital classifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Capital classifications. 1777.20 Section 1777... DEVELOPMENT SAFETY AND SOUNDNESS PROMPT CORRECTIVE ACTION Capital Classifications and Orders Under Section 1366 of the 1992 Act § 1777.20 Capital classifications. (a) Capital classifications after the...

  5. 47 CFR 65.304 - Capital structure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Capital structure. 65.304 Section 65.304... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.304 Capital structure. The proportion of each cost of capital component in the capital structure is equal to: Proportion in the...

  6. 47 CFR 65.304 - Capital structure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Capital structure. 65.304 Section 65.304... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.304 Capital structure. The proportion of each cost of capital component in the capital structure is equal to: Proportion in the...

  7. Role of Standard Demand Response Signals for Advanced Automated Aggregation

    SciTech Connect

    Lawrence Berkeley National Laboratory; Kiliccote, Sila

    2011-11-18

    Emerging standards such as OpenADR enable Demand Response (DR) Resources to interact directly with Utilities and Independent System Operators to allow their facility automation equipment to respond to a variety of DR signals ranging from day ahead to real time ancillary services. In addition, there are Aggregators in today’s markets who are capable of bringing together collections of aggregated DR assets and selling them to the grid as a single resource. However, in most cases these aggregated resources are not automated and when they are, they typically use proprietary technologies. There is a need for a framework for dealing with aggregated resources that supports the following requirements: • Allows demand-side resources to participate in multiple DR markets ranging from wholesale ancillary services to retail tariffs without being completely committed to a single entity like an Aggregator; • Allow aggregated groups of demand-side resources to be formed in an ad hoc fashion to address specific grid-side issues and support the optimization of the collective response of an aggregated group along a number of different dimensions. This is important in order to taylor the aggregated performance envelope to the needs to of the grid; • Allow aggregated groups to be formed in a hierarchical fashion so that each group can participate in variety of markets from wholesale ancillary services to distribution level retail tariffs. This paper explores the issues of aggregated groups of DR resources as described above especially within the context of emerging smart grid standards and the role they will play in both the management and interaction of various grid-side entities with those resources.

  8. Measuring and modeling hemoglobin aggregation below the freezing temperature.

    PubMed

    Rosa, Mónica; Lopes, Carlos; Melo, Eduardo P; Singh, Satish K; Geraldes, Vitor; Rodrigues, Miguel A

    2013-08-01

    Freezing of protein solutions is required for many applications such as storage, transport, or lyophilization; however, freezing has inherent risks for protein integrity. It is difficult to study protein stability below the freezing temperature because phase separation constrains solute concentration in solution. In this work, we developed an isochoric method to study protein aggregation in solutions at -5, -10, -15, and -20 °C. Lowering the temperature below the freezing point in a fixed volume prevents the aqueous solution from freezing, as pressure rises until equilibrium (P,T) is reached. Aggregation rates of bovine hemoglobin (BHb) increased at lower temperature (-20 °C) and higher BHb concentration. However, the addition of sucrose substantially decreased the aggregation rate and prevented aggregation when the concentration reached 300 g/L. The unfolding thermodynamics of BHb was studied using fluorescence, and the fraction of unfolded protein as a function of temperature was determined. A mathematical model was applied to describe BHb aggregation below the freezing temperature. This model was able to predict the aggregation curves for various storage temperatures and initial concentrations of BHb. The aggregation mechanism was revealed to be mediated by an unfolded state, followed by a fast growth of aggregates that readily precipitate. The aggregation kinetics increased for lower temperature because of the higher fraction of unfolded BHb closer to the cold denaturation temperature. Overall, the results obtained herein suggest that the isochoric method could provide a relatively simple approach to obtain fundamental thermodynamic information about the protein and the aggregation mechanism, thus providing a new approach to developing accelerated formulation studies below the freezing temperature. PMID:23808610

  9. Force aggregation using genetic algortihms

    NASA Astrophysics Data System (ADS)

    Shea, Peter J.; Peterson, John; Alexander, Kathleen; Azevedo, Alcino

    2004-01-01

    A surveillance system needs to accurately locate and identify not only single targets, but also groups of targets engaged in a common activity. Most existing tracking systems are capable of tracking individual targets quite accurately; however, they fail to use information related to group behavior in order to improve these estimates. Furthermore, in wide area surveillance situations a military operator is required to sort through hundreds to thousands of individual targets in order to develop an understanding of the situation. Having the ability to collapse the behavior of individual targets into a common, coordinated motion can greatly enhance the productively and situational awareness of the operator. Our long-term approach to solving this problem is to develop an understanding of how to define a group and then to understand the inter-relationships between the various characteristics that describe a group. Then using this information, we will be able to partition the set of target into groups that can be aggregated over the entire military force hierarchy. This goal of this paper is to describe an approach that is based upon genetic algorithms for solving the military force hierarchy problem. This paper will describe the underlying genetic algorithm, scoring function, and some initial results.

  10. Force aggregation using genetic algortihms

    NASA Astrophysics Data System (ADS)

    Shea, Peter J.; Peterson, John; Alexander, Kathleen; Azevedo, Alcino

    2003-12-01

    A surveillance system needs to accurately locate and identify not only single targets, but also groups of targets engaged in a common activity. Most existing tracking systems are capable of tracking individual targets quite accurately; however, they fail to use information related to group behavior in order to improve these estimates. Furthermore, in wide area surveillance situations a military operator is required to sort through hundreds to thousands of individual targets in order to develop an understanding of the situation. Having the ability to collapse the behavior of individual targets into a common, coordinated motion can greatly enhance the productively and situational awareness of the operator. Our long-term approach to solving this problem is to develop an understanding of how to define a group and then to understand the inter-relationships between the various characteristics that describe a group. Then using this information, we will be able to partition the set of target into groups that can be aggregated over the entire military force hierarchy. This goal of this paper is to describe an approach that is based upon genetic algorithms for solving the military force hierarchy problem. This paper will describe the underlying genetic algorithm, scoring function, and some initial results.

  11. Aggregate Models of Climate Change

    NASA Astrophysics Data System (ADS)

    Hooss, G.; Voss, R.; Hasselmann, K.; Maier-Reimer, E.; Joos, F.

    Integrated assessment of climate change generally requires the evaluation of many transient scenario simulations of century-timescale changes in atmospheric compo- sition and climate, desirably with the accuracy of state-of-the-art three-dimensional (3D) coupled atmosphere-ocean general circulation models (GCMs). Such multi- scenario GCM computations are possible through appropriate representation of the models in aggregate forms. For this purpose, we developed Nonlinear Impulse- response projections of 3D models of the global (oceanic and terrestrial) Carbon cycle and the atmosphere-ocean Climate System (NICCS). For higher CO2 forcing, appli- cability is extended beyond the linear response domain through explicit treatment of dominant nonlinear effects. The climate change module was furthermore augmented with spatial patterns of change in some of the most impact-relevant fields. Applied to three long-term CO2 emission scenarios, the model demonstrates (a) the minor rela- tive role of the terrestrial carbon sink through CO2 fertilization, and (b) the necessity to reduce fossil carbon emissions to a very small fraction of today's rates within the next few decades if a major climate change is to be avoided.

  12. Important features of Sustainable Aggregate Resource Management

    USGS Publications Warehouse

    Solar, Slavko V.; Shields, Deborah J.; Langer, William H.

    2004-01-01

    Every society, whether developed, developing or in a phase of renewal following governmental change, requires stable, adequate and secure supplies of natural resources. In the latter case, there could be significant need for construction materials for rebuilding infrastructure, industrial capacity, and housing. It is essential that these large-volume materials be provided in a rational manner that maximizes their societal contribution and minimizes environmental impacts. We describe an approach to resource management based on the principles of sustainable developed. Sustainable Aggregate Resource Management offers a way of addressing the conflicting needs and interests of environmental, economic, and social systems. Sustainability is an ethics based concept that utilizes science and democratic processes to reach acceptable agreements and tradeoffs among interests, while acknowledging the fundamental importance of the environment and social goods. We discuss the features of sustainable aggregate resource management.

  13. Minority Capital Resource Handbook. A Guide to Raising Capital for Minority Entrepreneurs. Second Edition.

    ERIC Educational Resources Information Center

    Ewing, Samuel D., Jr.; Maloney, Clifton H. W.

    This minority capital resource handbook consists of a guide to raising capital for minority entrepreneurs and a listing of sources that provide such capital. The first section deals with the process of raising capital. The realities of raising capital, intermediaries and financial advisors, and assessing needs are outlined. Factors considered in…

  14. Measuring the value of groundwater and other forms of natural capital

    PubMed Central

    Fenichel, Eli P.; Abbott, Joshua K.; Bayham, Jude; Boone, Whitney; Haacker, Erin M. K.; Pfeiffer, Lisa

    2016-01-01

    Valuing natural capital is fundamental to measuring sustainability. The United Nations Environment Programme, World Bank, and other agencies have called for inclusion of the value of natural capital in sustainability metrics, such as inclusive wealth. Much has been written about the importance of natural capital, but consistent, rigorous valuation approaches compatible with the pricing of traditional forms of capital have remained elusive. We present a guiding quantitative framework enabling natural capital valuation that is fully consistent with capital theory, accounts for biophysical and economic feedbacks, and can guide interdisciplinary efforts to measure sustainability. We illustrate this framework with an application to groundwater in the Kansas High Plains Aquifer, a rapidly depleting asset supporting significant food production. We develop a 10-y time series (1996−2005) of natural capital asset prices that accounts for technological, institutional, and physical changes. Kansas lost approximately $110 million per year (2005 US dollars) of capital value through groundwater withdrawal and changes in aquifer management during the decade spanning 1996–2005. This annual loss in wealth is approximately equal to the state’s 2005 budget surplus, and is substantially more than investments in schools over this period. Furthermore, real investment in agricultural capital also declined over this period. Although Kansas’ depletion of water wealth is substantial, it may be tractably managed through careful groundwater management and compensating investments in other natural and traditional assets. Measurement of natural capital value is required to inform management and ongoing investments in natural assets. PMID:26858431

  15. Measuring the value of groundwater and other forms of natural capital.

    PubMed

    Fenichel, Eli P; Abbott, Joshua K; Bayham, Jude; Boone, Whitney; Haacker, Erin M K; Pfeiffer, Lisa

    2016-03-01

    Valuing natural capital is fundamental to measuring sustainability. The United Nations Environment Programme, World Bank, and other agencies have called for inclusion of the value of natural capital in sustainability metrics, such as inclusive wealth. Much has been written about the importance of natural capital, but consistent, rigorous valuation approaches compatible with the pricing of traditional forms of capital have remained elusive. We present a guiding quantitative framework enabling natural capital valuation that is fully consistent with capital theory, accounts for biophysical and economic feedbacks, and can guide interdisciplinary efforts to measure sustainability. We illustrate this framework with an application to groundwater in the Kansas High Plains Aquifer, a rapidly depleting asset supporting significant food production. We develop a 10-y time series (1996-2005) of natural capital asset prices that accounts for technological, institutional, and physical changes. Kansas lost approximately $110 million per year (2005 US dollars) of capital value through groundwater withdrawal and changes in aquifer management during the decade spanning 1996-2005. This annual loss in wealth is approximately equal to the state's 2005 budget surplus, and is substantially more than investments in schools over this period. Furthermore, real investment in agricultural capital also declined over this period. Although Kansas' depletion of water wealth is substantial, it may be tractably managed through careful groundwater management and compensating investments in other natural and traditional assets. Measurement of natural capital value is required to inform management and ongoing investments in natural assets. PMID:26858431

  16. Microelectrode Measurements of the Activity Distribution in Nitrifying Bacterial Aggregates

    PubMed Central

    de Beer, D.; van den Heuvel, J. C.; Ottengraf, S. P. P.

    1993-01-01

    Microelectrodes for ammonium, oxygen, nitrate, and pH were used to study nitrifying aggregates grown in a fluidized-bed reactor. Local reactant fluxes and distribution of microbial activity could be determined from the microprofiles. The interfacial fluxes of the reactants closely reflected the stoichiometry of bacterial nitrification. Both ammonium consumption and nitrate production were localized in the outer shells, with a thickness of approximately 100 to 120 μm, of the aggregates. Under conditions in which ammonium and oxygen penetrated the whole aggregate, nitrification was restricted to this zone; oxygen was consumed in the central parts of the aggregates as well, probably because of oxidation of dead biomass. A sudden increase of the oxygen concentration to saturation (pure oxygen) was inhibitory to nitrification. The pH profiles showed acidification in the aggregates, but not to an inhibitory level. The distribution of activity was determined by the penetration depth of oxygen during aggregate development in the reactor. Mass transfer was significantly limited by the boundary layer surrounding the aggregates. Microelectrode measurements showed that the thickness of this layer was correlated with the diffusion coefficient of the species. Determination of the distribution of nitrifying activity required the use of ammonium or nitrate microelectrodes, whereas the use of oxygen microelectrodes alone would lead to erroneous results. Images PMID:16348875

  17. Ceramic ware waste as coarse aggregate for structural concrete production.

    PubMed

    García-González, Julia; Rodríguez-Robles, Desirée; Juan-Valdés, Andrés; Morán-Del Pozo, Julia M; Guerra-Romero, M Ignacio

    2015-01-01

    The manufacture of any kind of product inevitably entails the production of waste. The quantity of waste generated by the ceramic industry, a very important sector in Spain, is between 5% and 8% of the final output and it is therefore necessary to find an effective waste recovery method. The aim of the study reported in the present article was to seek a sustainable means of managing waste from the ceramic industry through the incorporation of this type of waste in the total replacement of conventional aggregate (gravel) used in structural concrete. Having verified that the recycled ceramic aggregates met all the technical requirements imposed by current Spanish legislation, established in the Code on Structural Concrete (EHE-08), then it is prepared a control concrete mix and the recycled concrete mix using 100% recycled ceramic aggregate instead of coarse natural aggregate. The concretes obtained were subjected to the appropriate tests in order to conduct a comparison of their mechanical properties. The results show that the concretes made using ceramic sanitary ware aggregate possessed the same mechanical properties as those made with conventional aggregate. It is therefore possible to conclude that the reuse of recycled ceramic aggregate to produce recycled concrete is a feasible alternative for the sustainable management of this waste. PMID:25188783

  18. Secure data aggregation in wireless sensor networks using homomorphic encryption

    NASA Astrophysics Data System (ADS)

    Kumar, Manish; Verma, Shekhar; Lata, Kusum

    2015-04-01

    In a Wireless Sensor Network (WSN), aggregation exploits the correlation between spatially and temporally proximate sensor data to reduce the total data volume to be transmitted to the sink. Mobile agents (MAs) fit into this paradigm, and data can be aggregated and collected by an MA from different sensor nodes using context specific codes. The MA-based data collection suffers due to large size of a typical WSN and is prone to security problems. In this article, homomorphic encryption in a clustered WSN has been proposed for secure and efficient data collection using MAs. The nodes keep encrypted data that are given to an MA for data aggregation tasks. The MA performs all the data aggregation operations upon encrypted data as it migrates between nodes in a tree-like structure in which the nodes are leafs and the cluster head is the root of the tree. It returns and deposits the encrypted aggregated data to the cluster head after traversing through all the intra cluster nodes over a shortest path route. The homomorphic encryption and aggregation processing in encrypted domain makes the data collection process secure. Simulation results confirm the effectiveness of the proposed secure data aggregation mechanism. In addition to security, MA-based mechanism leads to lesser delay and bandwidth requirements.

  19. 12 CFR 390.466 - Risk-based capital credit risk-weight categories.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Corporation Improvement Act of 1991 (12 U.S.C. 4401-4407), or Regulation EE (12 CFR part 231). (3) If the... Administration in 13 CFR 121 pursuant to 15 U.S.C. 632. (ii) Capital requirement. Notwithstanding any other... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Risk-based capital credit...

  20. 12 CFR 390.466 - Risk-based capital credit risk-weight categories.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Corporation Improvement Act of 1991 (12 U.S.C. 4401-4407), or Regulation EE (12 CFR part 231). (3) If the... Administration in 13 CFR 121 pursuant to 15 U.S.C. 632. (ii) Capital requirement. Notwithstanding any other... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Risk-based capital credit...

  1. 26 CFR 1.381(c)(3)-1 - Capital loss carryovers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Capital loss carryovers. 1.381(c)(3)-1 Section 1.381(c)(3)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(3)-1 Capital loss carryovers. (a) Carryover requirement. (1) Section...

  2. 38 CFR 61.13 - Rating criteria for capital grant applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... capital grant applications. 61.13 Section 61.13 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF... capital grant applications. (a) Applicants that meet the threshold requirements in § 61.12 of this part... which the application demonstrates experience in the following areas: (1) Engaging the participation...

  3. 38 CFR 61.13 - Rating criteria for capital grant applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... capital grant applications. 61.13 Section 61.13 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF... capital grant applications. (a) Applicants that meet the threshold requirements in § 61.12 of this part... which the application demonstrates experience in the following areas: (1) Engaging the participation...

  4. 26 CFR 1.818-8 - Special rules relating to consolidated returns and certain capital losses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and certain capital losses. 1.818-8 Section 1.818-8 Internal Revenue INTERNAL REVENUE SERVICE... Special rules relating to consolidated returns and certain capital losses. Section 818(g) provides that, in the case of a life insurance company filing or required to file a consolidated return...

  5. 12 CFR Appendix E to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Market Risk

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-Based Capital Ratio Calculations Section 5 VaR-based Measure Section 6 Stressed VaR-based Measure... establishes risk-based capital requirements for bank holding companies with significant exposure to market risk and provides methods for these bank holding companies to calculate their risk-based...

  6. 13 CFR 120.427 - Will SBA approve a securitization application from a capital impaired Securitizer?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Will SBA approve a securitization... securitization application from a capital impaired Securitizer? If a securitizer does not maintain the level of capital required by this subpart, SBA will not approve a securitization application from that securitizer....

  7. Model for amorphous aggregation processes

    NASA Astrophysics Data System (ADS)

    Stranks, Samuel D.; Ecroyd, Heath; van Sluyter, Steven; Waters, Elizabeth J.; Carver, John A.; von Smekal, Lorenz

    2009-11-01

    The amorphous aggregation of proteins is associated with many phenomena, ranging from the formation of protein wine haze to the development of cataract in the eye lens and the precipitation of recombinant proteins during their expression and purification. While much literature exists describing models for linear protein aggregation, such as amyloid fibril formation, there are few reports of models which address amorphous aggregation. Here, we propose a model to describe the amorphous aggregation of proteins which is also more widely applicable to other situations where a similar process occurs, such as in the formation of colloids and nanoclusters. As first applications of the model, we have tested it against experimental turbidimetry data of three proteins relevant to the wine industry and biochemistry, namely, thaumatin, a thaumatinlike protein, and α -lactalbumin. The model is very robust and describes amorphous experimental data to a high degree of accuracy. Details about the aggregation process, such as shape parameters of the aggregates and rate constants, can also be extracted.

  8. Glycation precedes lens crystallin aggregation

    SciTech Connect

    Swamy, M.S.; Perry, R.E.; Abraham, E.C.

    1987-05-01

    Non-enzymatic glycosylation (glycation) seems to have the potential to alter the structure of crystallins and make them susceptible to thiol oxidation leading to disulfide-linked high molecular weight (HMW) aggregate formation. They used streptozotocin diabetic rats during precataract and cataract stages and long-term cell-free glycation of bovine lens crystallins to study the relationship between glycation and lens crystallin aggregation. HMW aggregates and other protein components of the water-soluble (WS) and urea-soluble (US) fractions were separated by molecular sieve high performance liquid chromatography. Glycation was estimated by both (/sup 3/H)NaBH/sub 4/ reduction and phenylboronate agarose affinity chromatography. Levels of total glycated protein (GP) in the US fractions were about 2-fold higher than in the WS fractions and there was a linear increase in GP in both WS and US fractions. This increase was parallelled by a corresponding increase in HMW aggregates. Total GP extracted by the affinity method from the US fraction showed a predominance of HMW aggregates and vice versa. Cell-free glycation studies with bovine crystallins confirmed the results of the animals studies. Increasing glycation caused a corresponding increase in protein insolubilization and the insoluble fraction thus formed also contained more glycated protein. It appears that lens protein glycation, HMW aggregate formation, and protein insolubilization are interrelated.

  9. Modifiers of mutant huntingtin aggregation

    PubMed Central

    Teuling, Eva; Bourgonje, Annika; Veenje, Sven; Thijssen, Karen; de Boer, Jelle; van der Velde, Joeri; Swertz, Morris; Nollen, Ellen

    2011-01-01

    Protein aggregation is a common hallmark of a number of age-related neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and polyglutamine-expansion disorders such as Huntington’s disease, but how aggregation-prone proteins lead to pathology is not known. Using a genome-wide RNAi screen in a C. elegans-model for polyglutamine aggregation, we previously identified 186 genes that suppress aggregation. Using an RNAi screen for human orthologs of these genes, we here present 26 human genes that suppress aggregation of mutant huntingtin in a human cell line. Among these are genes that have not been previously linked to mutant huntingtin aggregation. They include those encoding eukaryotic translation initiation, elongation and translation factors, and genes that have been previously associated with other neurodegenerative diseases, like the ATP-ase family gene 3-like 2 (AFG3L2) and ubiquitin-like modifier activating enzyme 1 (UBA1). Unravelling the role of these genes will broaden our understanding of the pathogenesis of Huntington’s disease. PMID:21915392

  10. Kinetic model for erythrocyte aggregation.

    PubMed

    Bertoluzzo, S M; Bollini, A; Rasia, M; Raynal, A

    1999-01-01

    It is well known that light transmission through blood is the most widely utilized method for the study of erythrocyte aggregation. The curves obtained had been considered empirically as exponential functions. In consequence, the process becomes characterized by an only parameter that varies with all the process factors without discrimination. In the present paper a mathematical model for RBC aggregation process is deduced in accordance with von Smoluchowski's theory about the kinetics of colloidal particles agglomeration. The equation fitted the experimental pattern of the RBC suspension optical transmittance closely and contained two parameters that estimate the most important characteristics of the aggregation process separately, i.e., (1) average size of rouleaux at equilibrium and (2) aggregation rate. The evaluation of the method was assessed by some factors affecting erythrocyte aggregation, such as temperature, plasma dilutions, Dextran 500, Dextran 70 and PVP 360, at different media concentrations, cellular membrane alteration by the alkylating agent TCEA, and decrease of medium osmolarity. Results were interpreted considering the process characteristics estimated by the parameters, and there were also compared with similar studies carried out by other authors with other methods. This analysis allowed us to conclude that the equation proposed is reliable and useful to study erythrocyte aggregation. PMID:10660481

  11. Ash Aggregates in Proximal Settings

    NASA Astrophysics Data System (ADS)

    Porritt, L. A.; Russell, K.

    2012-12-01

    Ash aggregates are thought to have formed within and been deposited by the eruption column and plume and dilute density currents and their associated ash clouds. Moist, turbulent ash clouds are considered critical to ash aggregate formation by facilitating both collision and adhesion of particles. Consequently, they are most commonly found in distal deposits. Proximal deposits containing ash aggregates are less commonly observed but do occur. Here we describe two occurrences of vent proximal ash aggregate-rich deposits; the first within a kimberlite pipe where coated ash pellets and accretionary lapilli are found within the intra-vent sequence; and the second in a glaciovolcanic setting where cored pellets (armoured lapilli) occur within <1 km of the vent. The deposits within the A418 pipe, Diavik Diamond Mine, Canada, are the residual deposits within the conduit and vent of the volcano and are characterised by an abundance of ash aggregates. Coated ash pellets are dominant but are followed in abundance by ash pellets, accretionary lapilli and rare cored pellets. The coated ash pellets typically range from 1 - 5 mm in diameter and have core to rim ratios of approximately 10:1. The formation and preservation of these aggregates elucidates the style and nature of the explosive phase of kimberlite eruption at A418 (and other pipes?). First, these pyroclasts dictate the intensity of the kimberlite eruption; it must be energetic enough to cause intense fragmentation of the kimberlite to produce a substantial volume of very fine ash (<62 μm). Secondly, the ash aggregates indicate the involvement of moisture coupled with the presence of dilute expanded eruption clouds. The structure and distribution of these deposits throughout the kimberlite conduit demand that aggregation and deposition operate entirely within the confines of the vent; this indicates that aggregation is a rapid process. Ash aggregates within glaciovolcanic sequences are also rarely documented. The

  12. The Economic Importance of Human Capital in Modernization.

    ERIC Educational Resources Information Center

    Schultz, Theodore W.

    1993-01-01

    Human capital invests in new forms of physical capital, hence, human capital is key to economic progress. Lists eight attributes of human capital; for example, human capital cannot be separated from person who has it, and human capital is not visible. Human capital is necessary component when attempting to improve a person's income and welfare in…

  13. A Comparative Analysis of the Validity of US State- and County-Level Social Capital Measures and Their Associations with Population Health

    PubMed Central

    Lee, Chul-joo; Kim, Daniel

    2014-01-01

    The goals of this study were to validate a number of available collective social capital measures at the U.S. state and county levels, and to examine the relative extent to which these social capital measures are associated with population health outcomes. Measures of social capital at the U.S. state level included aggregate indices based on the Annenberg National Health Communication Survey (ANHCS) and the Behavioral Risk Factor Surveillance System (BRFSS), Petris Social Capital Index (PSCI), Putnam’s index, and Kim et al.’s scales. County-level measures consisted of Rupasingha et al.’s social capital index (RGFI) and a BRFSS-derived measure. These measures, except for the PSCI, showed evidence of acceptable validity. Moreover, we observed differences across the social capital measures in their associations with population health outcomes. The implications of the findings for future research in this area are discussed. PMID:25574069

  14. On the (In)Consistency of Citizen and Municipal Level Indicators of Social Capital and Local Government Performance

    ERIC Educational Resources Information Center

    Kampen, Jarl K.

    2010-01-01

    We study the empirical consistency of survey based (micro level) indicators of social capital and local government performance on the one, and municipality based (aggregate level) measures of these two concepts on the other hand. Knowledge about the behavior of these indicators is helpful for evaluating the value of studies carried out in isolated…

  15. Neighborhood racial composition, social capital and black all-cause mortality in Philadelphia.

    PubMed

    Hutchinson, Rebbeca N; Putt, Mary A; Dean, Lorraine T; Long, Judith A; Montagnet, Chantal A; Armstrong, Katrina

    2009-05-01

    Neighborhood characteristics such as racial composition and social capital have been widely linked to health outcomes, but the direction of the relationship between these characteristics and health of minority populations is controversial. Given this uncertainty, we examined the relationship between neighborhood racial composition, social capital, and black all-cause mortality between 1997 and 2000 in 68 Philadelphia neighborhoods. Data from the U.S. Census, the Philadelphia Health Management Corporation's 2004 Southeast Pennsylvania Community Health Survey, and city vital statistics were linked by census tract and then aggregated into neighborhoods, which served as the unit of analysis. Neighborhood social capital was measured by a summative score of respondent assessments of: the livability of their community, the likelihood of neighbors helping one another, their sense of belonging, and the trustworthiness of their neighbors. After adjustment for the sociodemographic characteristics of neighborhood residents, black age-adjusted all-cause mortality was significantly higher in neighborhoods that had lower proportion of black residents. Neighborhood social capital was also associated with lower black mortality, with the strongest relationship seen for neighborhoods in the top half of social capital scores. There was a significant interaction between racial composition and social capital, so that the effect of social capital on mortality was greatest in neighborhoods with a higher proportion of black residents and the effect of racial composition was greatest in neighborhoods with high social capital. These results demonstrate that age-adjusted all-cause black mortality is lowest in mostly black neighborhoods with high levels of social capital in Philadelphia. PMID:19324485

  16. Commercial Building Tenant Energy Usage Aggregation and Privacy

    SciTech Connect

    Livingston, Olga V.; Pulsipher, Trenton C.; Anderson, David M.; Wang, Na

    2014-10-31

    A growing number of building owners are benchmarking their building energy use. This requires the building owner to acquire monthly whole-building energy usage information, which can be challenging for buildings in which individual tenants have their own utility meters and accounts with the utility. Some utilities and utility regulators have turned to aggregation of customer energy use data (CEUD) as a way to give building owners whole-building energy usage data while protecting customer privacy. Meter profile aggregation adds a layer of protection that decreases the risk of revealing CEUD as the number of meters aggregated increases. The report statistically characterizes the similarity between individual energy usage patterns and whole-building totals at various levels of meter aggregation.

  17. Utilization of sewage sludge in the manufacture of lightweight aggregate.

    PubMed

    Franus, Małgorzata; Barnat-Hunek, Danuta; Wdowin, Magdalena

    2016-01-01

    This paper presents a comprehensive study on the possibility of sewage sludge management in a sintered ceramic material such as a lightweight aggregate. Made from clay and sludge lightweight aggregates were sintered at two temperatures: 1100 °C (name of sample LWA1) and 1150 °C (name of sample LWA2). Physical and mechanical properties indicate that the resulting expanded clay aggregate containing sludge meets the basic requirements for lightweight aggregates. The presence of sludge supports the swelling of the raw material, thereby causing an increase in the porosity of aggregates. The LWA2 has a lower value of bulk particle density (0.414 g/cm(3)), apparent particle density (0.87 g/cm(3)), and dry particle density (2.59 g/cm(3)) than it is in the case of LWA1 where these parameters were as follows: bulk particle density 0.685 g/cm(3), apparent particle density 1.05 g/cm(3), and dry particle density 2.69 g/cm(3). Water absorption and porosity of LWA1 (WA = 14.4 %, P = 60 %) are lower than the LWA2 (WA = 16.2 % and P = 66 %). This is due to the higher heating temperature of granules which make the waste gases, liberating them from the decomposition of organic sewage sludge. The compressive strength of LWA2 aggregate is 4.64 MPa and for LWA1 is 0.79 MPa. Results of leaching tests of heavy metals from examined aggregates have shown that insoluble metal compounds are placed in silicate and aluminosilicate structure of the starting materials (clays and sludges), whereas soluble substances formed crystalline skeleton of the aggregates. The thermal synthesis of lightweight aggregates from clay and sludge mixture is a waste-free method of their development. PMID:26635022

  18. The measurement of social capital.

    PubMed

    Villalonga-Olives, Ester; Kawachi, Ichiro

    2015-01-01

    Social capital has been defined as the resources available to individuals and groups through membership in social networks. The definition is consistent with either an individualistic approach, i.e. resources (such as information or instrumental assistance) that are accessed by individuals through their network connections; or a collective approach, e.g. the benefits accruing to members of a group - such as the ability of a community to engage in collective action - as a consequence of the existence of cohesive relationships. While research often restricts itself to a single level of analysis, the benefits (and downsides) of social capital accrue to both the individual as well as to the network to which he belongs. In the Dictionary of Epidemiology both the individual and collective levels of analysis were recognized in the definition of social capital. PMID:25444390

  19. Crystal aggregation in kidney stones; a polymer aggregation problem?

    NASA Astrophysics Data System (ADS)

    Wesson, J.; Beshensky, A.; Viswanathan, P.; Zachowicz, W.; Kleinman, J.

    2008-03-01

    Kidney stones most frequently form as aggregates of calcium oxalate monohydrate (COM) crystals with organic layers between them, and the organic layers contain principally proteins. The pathway leading to the formation of these crystal aggregates in affected people has not been identified, but stone forming patients are thought to have a defect in the structure or distribution of urinary proteins, which normally protect against stone formation. We have developed two polyelectrolyte models that will induce COM crystal aggregation in vitro, and both are consistent with possible urinary protein compositions. The first model was based on mixing polyanionic and polycationic proteins, in portions such that the combined protein charge is near zero. The second model was based on reducing the charge density on partially charged polyanionic proteins, specifically Tamm-Horsfall protein, the second most abundant protein in urine. Both models demonstrated polymer phase separation at solution conditions where COM crystal aggregation was observed. Correlation with data from other bulk crystallization measurements suggest that the anionic side chains form critical binding interactions with COM surfaces that are necessary along with the phase separation process to induce COM crystal aggregation.

  20. 28 CFR 26.22 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE DEATH SENTENCES PROCEDURES Certification Process for State Capital Counsel Systems § 26.22 Requirements. A state meets the requirements for certification under 28 U... educational programs on postconviction criminal litigation and the defense of capital cases; (2)...

  1. 12 CFR 932.7 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... to the Finance Board by the 15th business day of each month its risk-based capital requirement...

  2. 12 CFR 932.7 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... to the Finance Board by the 15th business day of each month its risk-based capital requirement...

  3. 12 CFR 932.7 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... to the Finance Board by the 15th business day of each month its risk-based capital requirement...

  4. 12 CFR 932.7 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... to the Finance Board by the 15th business day of each month its risk-based capital requirement...

  5. 12 CFR 932.7 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL... to the Finance Board by the 15th business day of each month its risk-based capital requirement...

  6. Putting Technology to Work on a Capital Project

    ERIC Educational Resources Information Center

    Hare, Dudley, Jr.

    2005-01-01

    Managing complex capital construction projects provides formidable challenges to school leaders. Increasing enrollment, new state mandates, aging schools and the need for technology-rich environments are issues that require both more space and better quality facilities. Short-handed district leadership teams already find themselves more than fully…

  7. 12 CFR 217.22 - Regulatory capital adjustments and deductions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., including retained earnings, in its financial subsidiaries (as defined in 12 CFR 208.77) and may not... Comptroller of the Currency; 18 18 These rules include the regulatory capital requirements set forth at 12 CFR part 3 (OCC); 12 CFR part 225 (Board); 12 CFR part 325, and 12 CFR part 390 (FDIC). (B) Prior to...

  8. 12 CFR 324.22 - Regulatory capital adjustments and deductions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., including retained earnings, in its financial subsidiaries (as defined in 12 CFR 362.17). An FDIC-supervised... regulatory capital requirements set forth at 12 CFR part 3 (OCC); 12 CFR part 225 (Board); 12 CFR part 325, and 12 CFR part 390 (FDIC). (iv) With prior notice to the FDIC, an FDIC-supervised...

  9. 12 CFR 5.46 - Changes in permanent capital.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 CFR part 16 for offers and sales of common and preferred stock. (k) Shareholder approval. A national bank shall obtain the necessary shareholder approval required by statute for any change in its..., including a plan to achieve minimum capital ratios filed with the appropriate district office under 12 CFR...

  10. 12 CFR 163.74 - Mutual capital certificates.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... capital requirements under part 167 of this chapter if a Federal savings association or 12 CFR part 390... a Federal savings association or 12 CFR part 390, subpart Z if a state savings association; And... having met specific financial standards; (viii) Not constitute an obligation of the association and...

  11. Cost of capital to the hospital sector.

    PubMed

    Sloan, F A; Valvona, J; Hassan, M; Morrisey, M A

    1988-03-01

    This paper provides estimates of the cost of equity and debt capital to for-profit and non-profit hospitals in the U.S. for the years 1972-83. The cost of equity is estimated using, alternatively, the Capital Asset Pricing Model and Arbitrage Pricing Theory. We find that the cost of equity capital, using either model, substantially exceeded anticipated inflation. The cost of debt capital was much lower. Accounting for the corporate tax shield on debt and capital paybacks by cost-based insurers lowered the net cost of capital to hospitals. PMID:10302653

  12. Gendered Capital: Emotional Capital and Mothers' Care Work in Education

    ERIC Educational Resources Information Center

    O'Brien, Maeve

    2008-01-01

    This paper is concerned with the inequalities experienced by mothers in the performance of educational care work for their children. It is argued that the caring work carried out by mothers at transfer to second-level schooling is shaped by their ability to activate the significant resource of emotional capital; a gendered resource involving…

  13. Fractal Aggregates in Tennis Ball Systems

    ERIC Educational Resources Information Center

    Sabin, J.; Bandin, M.; Prieto, G.; Sarmiento, F.

    2009-01-01

    We present a new practical exercise to explain the mechanisms of aggregation of some colloids which are otherwise not easy to understand. We have used tennis balls to simulate, in a visual way, the aggregation of colloids under reaction-limited colloid aggregation (RLCA) and diffusion-limited colloid aggregation (DLCA) regimes. We have used the…

  14. A PROPOSED FRAMEWORK FOR PLANNING DEACTIVATION AND DECOMMISSIONING ENGINEERING AND DESIGN ACTIVITIES TO MEET THE REQUIREMENTS OF DOE ORDER 413.3A, PROGRAM AND PROJECT MANAGEMENT FOR THE ACQUISITION OF CAPITAL ASSETS

    SciTech Connect

    Santos, J; John Gladden, J

    2007-11-06

    This paper provides guidance in applying the requirements of DOE O 413.3A to Deactivation and Decommissioning (D&D) projects. A list of 41 engineering and design activities relevant to D&D projects was generated. For several activities in this list, examples of the level of development and/or types of deliverables that might be expected at the completion of the conceptual, preliminary and final project design phases described in the Order are provided.

  15. Aggregated Recommendation through Random Forests

    PubMed Central

    2014-01-01

    Aggregated recommendation refers to the process of suggesting one kind of items to a group of users. Compared to user-oriented or item-oriented approaches, it is more general and, therefore, more appropriate for cold-start recommendation. In this paper, we propose a random forest approach to create aggregated recommender systems. The approach is used to predict the rating of a group of users to a kind of items. In the preprocessing stage, we merge user, item, and rating information to construct an aggregated decision table, where rating information serves as the decision attribute. We also model the data conversion process corresponding to the new user, new item, and both new problems. In the training stage, a forest is built for the aggregated training set, where each leaf is assigned a distribution of discrete rating. In the testing stage, we present four predicting approaches to compute evaluation values based on the distribution of each tree. Experiments results on the well-known MovieLens dataset show that the aggregated approach maintains an acceptable level of accuracy. PMID:25180204

  16. Aggregated recommendation through random forests.

    PubMed

    Zhang, Heng-Ru; Min, Fan; He, Xu

    2014-01-01

    Aggregated recommendation refers to the process of suggesting one kind of items to a group of users. Compared to user-oriented or item-oriented approaches, it is more general and, therefore, more appropriate for cold-start recommendation. In this paper, we propose a random forest approach to create aggregated recommender systems. The approach is used to predict the rating of a group of users to a kind of items. In the preprocessing stage, we merge user, item, and rating information to construct an aggregated decision table, where rating information serves as the decision attribute. We also model the data conversion process corresponding to the new user, new item, and both new problems. In the training stage, a forest is built for the aggregated training set, where each leaf is assigned a distribution of discrete rating. In the testing stage, we present four predicting approaches to compute evaluation values based on the distribution of each tree. Experiments results on the well-known MovieLens dataset show that the aggregated approach maintains an acceptable level of accuracy. PMID:25180204

  17. Internal modelling under Risk-Based Capital (RBC) framework

    NASA Astrophysics Data System (ADS)

    Ling, Ang Siew; Hin, Pooi Ah

    2015-12-01

    Very often the methods for the internal modelling under the Risk-Based Capital framework make use of the data which are in the form of run-off triangle. The present research will instead extract from a group of n customers, the historical data for the sum insured si of the i-th customer together with the amount paid yij and the amount aij reported but not yet paid in the j-th development year for j = 1, 2, 3, 4, 5, 6. We model the future value (yij+1, aij+1) to be dependent on the present year value (yij, aij) and the sum insured si via a conditional distribution which is derived from a multivariate power-normal mixture distribution. For a group of given customers with different original purchase dates, the distribution of the aggregate claims liabilities may be obtained from the proposed model. The prediction interval based on the distribution for the aggregate claim liabilities is found to have good ability of covering the observed aggregate claim liabilities.

  18. Aggregation operations for multiaspect fuzzy soft sets

    NASA Astrophysics Data System (ADS)

    Sulaiman, Nor Hashimah; Mohamad, Daud

    2015-10-01

    Multiaspect fuzzy soft set (MAFSS) is one of the generalized forms of fuzzy soft sets. In this paper, we introduce two types of aggregation operations for MAFSSs, namely the weighted arithmetic mean (WAM)-based MAFSS aggregation, and the ordered weighted aggregation (OWA)-based MAFSS aggregation. The applicability of the two MAFSS-aggregation operations is illustrated with numerical examples in group decision making.

  19. 76 FR 42768 - Capital Distribution

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... Office of Thrift Supervision Capital Distribution AGENCY: Office of Thrift Supervision (OTS), Treasury... Reduction Act of 1995, 44 U.S.C. 3507. The Office of Thrift Supervision within the Department of the... Thrift Supervision, 1700 G Street, NW., Washington, DC 20552. FOR FURTHER INFORMATION CONTACT: You...

  20. School Cheating and Social Capital

    ERIC Educational Resources Information Center

    Paccagnella, Marco; Sestito, Paolo

    2014-01-01

    In this paper we investigate the relationship between social capital and cheating behaviour in standardized tests. Given the low-stakes nature of these tests, we interpret the widespread presence of cheating as a signal of low trust towards central education authorities and as lack of respect for the rule of law. We find that cheating is…

  1. Social Capital and Community Heterogeneity

    ERIC Educational Resources Information Center

    Coffe, Hilde

    2009-01-01

    Recent findings indicate that more pronounced community heterogeneity is associated with lower levels of social capital. These studies, however, concentrate on specific aspects in which people differ (such as income inequality or ethnic diversity). In the present paper, we introduce the number of parties in the local party system as a more…

  2. 76 FR 11668 - Minimum Capital

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... Enterprises' future, FHFA is monitoring the activities of the Enterprises to: (a) Limit their risk and... 12 U.S.C. 4612(d). The 60-day comment period closed on April 9, 2010. See Federal Register 75 FR 6151... amended. See 74 FR 5597 (January 30, 2009). As a result, the definition of ``minimum capital level''...

  3. Capital Punishment: An International Perspective.

    ERIC Educational Resources Information Center

    Kaufman, Edy

    1983-01-01

    The debate over the death penalty in the United States has implications beyond our borders. Because of the lack of universal standards governing its use, only those countries which have abolished capital punishment may, with any moral authority, denounce its exploitation as an instrument of political expediency. (IS)

  4. Modeling and Measuring Organization Capital

    ERIC Educational Resources Information Center

    Atkeson, Andrew; Kehoe, Patrick J.

    2005-01-01

    Manufacturing plants have a clear life cycle: they are born small, grow substantially with age, and eventually die. Economists have long thought that this life cycle is driven by organization capital, the accumulation of plant-specific knowledge. The location of plants in the life cycle determines the size of the payments, or organization rents,…

  5. A Radical Redistribution of Capital

    ERIC Educational Resources Information Center

    Weiston-Serdan, Torie L.

    2009-01-01

    The study of capital in all of its forms has provided key insights into the system of education: its structure, its inequities, its values and its contributions. While the research is a key component to understanding educational opportunity and inequity, it does not advance from research to application. There is a general consensus that the…

  6. Teachers, Networks and Social Capital

    ERIC Educational Resources Information Center

    Healey, Kaleen

    2013-01-01

    A growing body of research suggests that school leaders and policymakers should attend to the social conditions within schools that promote instructional improvement and student achievement gains. This dissertation uses theoretical and empirical work on social capital to frame three aspects of the relationships among teachers. The three studies…

  7. Economic Analysis of Social Common Capital

    NASA Astrophysics Data System (ADS)

    Uzawa, Hirofumi

    2005-06-01

    Social common capital provides members of society with those services and institutional arrangements that are crucial in maintaining human and cultural life. The term æsocial common capital' is comprised of three categories: natural capital, social infrastructure, and institutional capital. Natural capital consists of all natural environment and natural resources including the earth's atmosphere. Social infrastructure consists of roads, bridges, public transportation systems, electricity, and other public utilities. Institutional capital includes hospitals, educational institutions, judicial and police systems, public administrative services, financial and monetary institutions, and cultural capital. This book attempts to modify and extend the theoretical premises of orthodox economic theory to make them broad enough to analyze the economic implications of social common capital. It further aims to find the institutional arrangements and policy measures that will bring about the optimal state of affairs.

  8. Social Capital and People with Learning Difficulties.

    ERIC Educational Resources Information Center

    Riddell, Sheila; Baron, Stephen; Wilson, Alastair

    1999-01-01

    Outlines social capital theories in functionalist and Marxist traditions and their implications for people with learning difficulties. Identifies multiple factors influencing their ability to access social capital, including ability/inability to conform to social norms and economic inequities. (SK)

  9. Role of Livelihood Capital in Reducing Climatic Vulnerability: Insights of Australian Wheat from 1990-2010.

    PubMed

    Huai, Jianjun

    2016-01-01

    In many agricultural countries, development of rural livelihood through increasing capital is a major regional policy to adapt to climate change. However, the role of livelihood capital in reducing climatic vulnerability is uncertain. This study assesses vulnerability and identifies the effects of common capital indicators on it, using Australian wheat as an example. We calculate exposure (a climate index) and sensitivity (a wheat failure index) to measure vulnerability and classify the resilient and sensitive cases, and express adaptive capacity through financial, human, natural, physical, and social capital indicators for 12 regions in the Australian wheat-sheep production zone from 1991-2010. We identify relationships between 12 indicators of five types of capital and vulnerability with t-tests and six logistic models considering the capital indicator itself, its first-order lag and its square as dependent variables to test the hypothesis that a high level of each capital metric results in low vulnerability. Through differing adaptive capacities between resilient and sensitive groups, we found that only four of the 12 (e.g., the access to finance, cash income level, total crop gross revenues, and family share of farm income) relate to vulnerability, which challenges the hypothesis that increasing capital reduces vulnerability. We conclude that further empirical reexaminations are required to test the relationships between capital measures and vulnerability under the sustainable livelihood framework (SLF). PMID:27022910

  10. Role of Livelihood Capital in Reducing Climatic Vulnerability: Insights of Australian Wheat from 1990–2010

    PubMed Central

    Huai, Jianjun

    2016-01-01

    In many agricultural countries, development of rural livelihood through increasing capital is a major regional policy to adapt to climate change. However, the role of livelihood capital in reducing climatic vulnerability is uncertain. This study assesses vulnerability and identifies the effects of common capital indicators on it, using Australian wheat as an example. We calculate exposure (a climate index) and sensitivity (a wheat failure index) to measure vulnerability and classify the resilient and sensitive cases, and express adaptive capacity through financial, human, natural, physical, and social capital indicators for 12 regions in the Australian wheat–sheep production zone from 1991–2010. We identify relationships between 12 indicators of five types of capital and vulnerability with t-tests and six logistic models considering the capital indicator itself, its first-order lag and its square as dependent variables to test the hypothesis that a high level of each capital metric results in low vulnerability. Through differing adaptive capacities between resilient and sensitive groups, we found that only four of the 12 (e.g., the access to finance, cash income level, total crop gross revenues, and family share of farm income) relate to vulnerability, which challenges the hypothesis that increasing capital reduces vulnerability. We conclude that further empirical reexaminations are required to test the relationships between capital measures and vulnerability under the sustainable livelihood framework (SLF). PMID:27022910

  11. Evaporation effects in elastocapillary aggregation

    NASA Astrophysics Data System (ADS)

    Vella, Dominic; Hadjittofis, Andreas; Singh, Kiran; Lister, John

    2015-11-01

    We consider the effect of evaporation on the aggregation of a number of elastic objects due to a liquid's surface tension. In particular, we consider an array of spring-block elements in which the gaps between blocks are filled by thin liquid films that evaporate during the course of an experiment. Using lubrication theory to account for the fluid flow within the gaps, we study the dynamics of aggregation. We find that a non-zero evaporation rate causes the elements to aggregate more quickly and, indeed, to contact within finite time. However, we also show that the number of elements within each cluster decreases as the evaporation rate increases. We explain these results quantitatively by comparison with the corresponding two-body problem and discuss their relevance for controlling pattern formation in carbon nanotube forests.

  12. Molecular Aggregation in Disodium Cromoglycate

    NASA Astrophysics Data System (ADS)

    Singh, Gautam; Agra-Kooijman, D.; Collings, P. J.; Kumar, Satyendra

    2012-02-01

    Details of molecular aggregation in the mesophases of the anti-asthmatic drug disodium cromoglycate (DSCG) have been studied using x-ray synchrotron scattering. The results show two reflections, one at wide angles corresponding to π-π stacking (3.32 å) of molecules, and the other at small angles which is perpendicular to the direction of molecular stacking and corresponds to the distance between the molecular aggregates. The latter varies from 35 - 41 å in the nematic (N) phase and 27 -- 32 å in the columnar (M) phase. The temperature evolution of the stack height, positional order correlations in the lateral direction, and orientation order parameter were determined in the N, M, and biphasic regions. The structure of the N and M phases and the nature of the molecular aggregation, together with their dependence on temperature and concentration, will be presented.

  13. Global kinetic analysis of seeded BSA aggregation.

    PubMed

    Sahin, Ziya; Demir, Yusuf Kemal; Kayser, Veysel

    2016-04-30

    Accelerated aggregation studies were conducted around the melting temperature (Tm) to elucidate the kinetics of seeded BSA aggregation. Aggregation was tracked by SEC-HPLC and intrinsic fluorescence spectroscopy. Time evolution of monomer, dimer and soluble aggregate concentrations were globally analysed to reliably deduce mechanistic details pertinent to the process. Results showed that BSA aggregated irreversibly through both sequential monomer addition and aggregate-aggregate interactions. Sequential monomer addition proceeded only via non-native monomers, starting to occur only by 1-2°C below the Tm. Aggregate-aggregate interactions were the dominant mechanism below the Tm due to an initial presence of small aggregates that acted as seeds. Aggregate-aggregate interactions were significant also above the Tm, particularly at later stages of aggregation when sequential monomer addition seemed to cease, leading in some cases to insoluble aggregate formation. The adherence (or non-thereof) of the mechanisms to Arrhenius kinetics were discussed alongside possible implications of seeding for biopharmaceutical shelf-life and spectroscopic data interpretation, the latter of which was found to often be overlooked in BSA aggregation studies. PMID:26970282

  14. Production of lightweight aggregate from industrial waste and carbon dioxide.

    PubMed

    Gunning, Peter J; Hills, Colin D; Carey, Paula J

    2009-10-01

    The concomitant recycling of waste and carbon dioxide emissions is the subject of developing technology designed to close the industrial process loop and facilitate the bulk-re-use of waste in, for example, construction. The present work discusses a treatment step that employs accelerated carbonation to convert gaseous carbon dioxide into solid calcium carbonate through a reaction with industrial thermal residues. Treatment by accelerated carbonation enabled a synthetic aggregate to be made from thermal residues and waste quarry fines. The aggregates produced had a bulk density below 1000 kg/m(3) and a high water absorption capacity. Aggregate crushing strengths were between 30% and 90% stronger than the proprietary lightweight expanded clay aggregate available in the UK. Cast concrete blocks containing the carbonated aggregate achieve compressive strengths of 24 MPa, making them suitable for use with concrete exposed to non-aggressive service environments. The energy intensive firing and sintering processes traditionally required to produce lightweight aggregates can now be augmented by a cold-bonding, low energy method that contributes to the reduction of green house gases to the atmosphere. PMID:19577916

  15. Lysozyme Aggregation and Fibrillation Monitored by Dynamic Light Scattering

    NASA Astrophysics Data System (ADS)

    Nemzer, Louis; Flanders, Bret; Schmit, Jeremy; Sorensen, Christopher

    2012-02-01

    The aggregation of amyloidogenic proteins provides a rich phase space with significant biomedical implications, including a link with several age-related diseases. We employed dynamic light scattering to monitor the aggregation of lysozyme, a model protein, from a monomeric state until the formation of micron-sized fibrils. For an aqueous lysozyme solution buffered at pH 2, the auto-correlation function of the scattered light intensity was found to be well-fit by a single exponential function with decay time τ = 1/(2Dq^2) = 0.25 ms, which corresponds to a mean hydrodynamic radius (RH) of 2.2 nm, very likely generated by monomers. Ethanol (4% v/v final concentration) induced a partial unfolding, to RH = 4.6 nm. The subsequent addition of 70 mM KCl was found to shrink the size back to RH = 2.5 nm, as expected when a denatured protein refolds due to partial screening of the intramolecular repulsion. However, further aggregation was not observed. At pH 4, using a low-salt acetate buffer, more ethanol (10% v/v) was required to initiate unfolding, but once it occurred, larger aggregates formed. These results are consistent with the model that partial unfolding, which exposes beta-motif secondary structure, is a prerequisite for aggregation and fibrillation, but the aggregation fate depends on the protein charge state (pH) and screening (salt concentration).

  16. Alteration of red blood cell aggregation during blood storage

    NASA Astrophysics Data System (ADS)

    Lim, Hyun-Jung; Nam, Jeong-Hun; Lee, Byoung-Kwon; Suh, Jang-Soo; Shin, Sehyun

    2011-06-01

    Even though the trade-off between the benefits and risks of blood transfusion has been discussed for the last several decades, it requires further understanding of the rheological changes in stored blood that include the alteration of red blood cell (RBC) aggregation. The RBC aggregation of stored blood in its autologous plasma was monitored through the storage period (35 days). The critical shear stress, as a measure of RBC aggregation, was determined by using a microfluidic aggregometer. Blood was processed into a blood bag containing the anticoagulant CPDA1 and stored at 4°C. It was subjected to assays after zero, seven, 14, and 35 days. The critical shear stress for stored blood did not change up to 14 days of storage but exhibited a significant decrease after 35 days of storage. These results were identical to those of the conventional aggregation index (AI). Also, in the alteration of RBC aggregation for blood storage, the effect of the plasma factor was slightly stronger than that of the cellular factor. Through the present study, the critical shear stress as a new measure of RBC aggregation may help to monitor and control the quality of blood storage.

  17. Cell-to-cell propagation of infectious cytosolic protein aggregates

    PubMed Central

    Hofmann, Julia P.; Denner, Philip; Nussbaum-Krammer, Carmen; Kuhn, Peer-Hendrik; Suhre, Michael H.; Scheibel, Thomas; Lichtenthaler, Stefan F.; Schätzl, Hermann M.; Bano, Daniele; Vorberg, Ina M.

    2013-01-01

    Prions are self-templating protein conformers that replicate by recruitment and conversion of homotypic proteins into growing protein aggregates. Originally identified as causative agents of transmissible spongiform encephalopathies, increasing evidence now suggests that prion-like phenomena are more common in nature than previously anticipated. In contrast to fungal prions that replicate in the cytoplasm, propagation of mammalian prions derived from the precursor protein PrP is confined to the cell membrane or endocytic vesicles. Here we demonstrate that cytosolic protein aggregates can also behave as infectious entities in mammalian cells. When expressed in the mammalian cytosol, protein aggregates derived from the prion domain NM of yeast translation termination factor Sup35 persistently propagate and invade neighboring cells, thereby inducing a self-perpetuating aggregation state of NM. Cell contact is required for efficient infection. Aggregates can also be induced in primary astrocytes, neurons, and organotypic cultures, demonstrating that this phenomenon is not specific to immortalized cells. Our data have important implications for understanding prion-like phenomena of protein aggregates associated with human diseases and for the growing number of amyloidogenic proteins discovered in mammals. PMID:23509289

  18. Analysis of Shear-Induced Platelet Aggregation and Breakup.

    PubMed

    Hellmuth, Rudolf; Bruzzi, Mark S; Quinlan, Nathan J

    2016-04-01

    To better understand the mechanisms leading to the formation of thrombi of hazardous sizes in the bulk of the blood, we have developed a kinetic model of shear-induced platelet aggregation (SIPA). In our model, shear rate regulates a mass-conservative population balance equation which computes the aggregation and disaggregation of platelets in a cluster mass distribution. Aggregation is modeled by the Smoluchowski coagulation equation, and disaggregation is incorporated using the aggregate breakup model of Pandya and Spielman. Previous experimental data for SIPA have been correlated with a special case of this model where only the two-body collision of free platelets was considered. However, the two-body collision theory is oblivious to the steady-state condition, and it required the use of a shear-dependent aggregation efficiency parameter to fit it to experimental data. Our method not only predicts steady states but also correlates with literature data without employing a shear-dependent aggregation efficiency. PMID:26228488

  19. Co-chaperone CHIP promotes aggregation of ataxin-1.

    PubMed

    Choi, Jung Young; Ryu, Jeong Hee; Kim, Hyo-Sun; Park, Sung Goo; Bae, Kwang-Hee; Kang, Sunghyun; Myung, Pyung Keun; Cho, Sayeon; Park, Byoung Chul; Lee, Do Hee

    2007-01-01

    Recent studies demonstrated that co-chaperone/E3 ligase CHIP (C-terminus of hsp70-interacting protein) mediates the ubiquitylation and suppresses the aggregation of polyglutamine (polyQ) proteins, such as huntingtin or ataxin-3. In this study, we investigated the effects of CHIP on the degradation of another polyQ protein ataxin-1. Interestingly CHIP associates not only with the polyQ-expanded ataxin-1 but also with the normal ataxin-1. Moreover, by enhancing ataxin-1 ubiquitylation, CHIP over-expression leads to a reduction in the solubility of ataxin-1 and thus increases the aggregate formation, especially that of polyQ-expanded ataxin-1. Domain analysis revealed that the TPR domain is required for the promotion of aggregation. By contrast, other co-chaperones or E3 ligases, such as BAG-1 or parkin, did not show similar effects on the aggregation of ataxin-1. Importantly, the effect of CHIP is impaired by the mutation of Ser776 of ataxin-1 whose phosphorylation is crucial for ataxin-1 aggregation. Our findings suggest that the role of CHIP in aggregation of polyQ proteins greatly varies depending on the context of full-length polyQ proteins. PMID:17127076

  20. 12 CFR 303.241 - Reduce or retire capital stock or capital debt instruments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Reduce or retire capital stock or capital debt... RULES OF PRACTICE FILING PROCEDURES Other Filings § 303.241 Reduce or retire capital stock or capital... nonmember bank to seek the prior approval of the FDIC to reduce the amount or retire any part of its...

  1. 12 CFR 933.5 - Disclosure to members concerning capital plan and capital stock conversion.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and capital stock conversion. 933.5 Section 933.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD... Disclosure to members concerning capital plan and capital stock conversion. (a) No capital plan shall become...) The terms of conversion; (iii) Redemption and repurchase rights; (iv) Voting rights and...

  2. 12 CFR 933.5 - Disclosure to members concerning capital plan and capital stock conversion.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and capital stock conversion. 933.5 Section 933.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD... Disclosure to members concerning capital plan and capital stock conversion. (a) No capital plan shall become...) The terms of conversion; (iii) Redemption and repurchase rights; (iv) Voting rights and...

  3. 12 CFR 933.5 - Disclosure to members concerning capital plan and capital stock conversion.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and capital stock conversion. 933.5 Section 933.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD... Disclosure to members concerning capital plan and capital stock conversion. (a) No capital plan shall become...) The terms of conversion; (iii) Redemption and repurchase rights; (iv) Voting rights and...

  4. 12 CFR 933.5 - Disclosure to members concerning capital plan and capital stock conversion.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and capital stock conversion. 933.5 Section 933.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD... Disclosure to members concerning capital plan and capital stock conversion. (a) No capital plan shall become...) The terms of conversion; (iii) Redemption and repurchase rights; (iv) Voting rights and...

  5. Psychological Capital, Career Identity and Graduate Employability in Uganda: The Mediating Role of Social Capital

    ERIC Educational Resources Information Center

    Ngoma, Muhammad; Dithan Ntale, Peter

    2016-01-01

    This paper seeks to evaluate the relationship between psychological capital, career identity, social capital and graduate employability. We also seek to evaluate the mediating role of social capital on the relationships between psychological capital, career identity and graduate employability in Uganda. A population of 480 unemployed young people…

  6. 12 CFR 933.5 - Disclosure to members concerning capital plan and capital stock conversion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Disclosure to members concerning capital plan and capital stock conversion. 933.5 Section 933.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS BANK CAPITAL STRUCTURE PLANS §...

  7. 12 CFR 303.241 - Reduce or retire capital stock or capital debt instruments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: (1) The type and amount of the proposed change to the capital structure and the reason for the change; (2) A schedule detailing the present and proposed capital structure; (3) The time period that the... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Reduce or retire capital stock or capital...

  8. 12 CFR 3.20 - Capital components and eligibility criteria for regulatory capital instruments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... capital rules under appendix A to this part (national banks), 12 CFR part 167 (Federal savings... tier 2 capital under the OCC's general risk-based capital rules under appendix A to this part, 12 CFR... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Capital components and eligibility criteria...

  9. Lightweight alumina refractory aggregate. Phase 2, Pilot scale development

    SciTech Connect

    Swansiger, T.G.; Pearson, A.

    1994-11-01

    Kilogram quantities of refractory aggregate were prepared from both a paste and a pelletized form of extruder feed material in both bench and pilot-scale equipment. The 99{sup +} % alumina aggregate exhibited a bulk density approaching 2.5 g/cm{sup 3} and a fired strength slightly lower than fused alumina. Based on initial evaluation by two refractory manufacturers in brick or castable applications, the new aggregate offered adequate strength with thermal conductivity reductions up to 34%, depending on the temperature and application of the new aggregate in these initial trials. The new aggregate was simply substituted for Tabular{trademark} in the refractory formulation. Thus, there is room for improvement through formulation optimization with the lightweight aggregate. The new aggregate offers a unique combination of density, strength, and thermal properties not available in current aggregate. To this point in time, technical development has led to a pelletized formulation with borderline physical form leaving the Eirich mixer. The formulation requires further development to provide more latitude for the production of pelletized material without forming paste, while still reducing the bulk density slightly to reach the 2.5 g/cm{sup 3} target. The preferred, pelletized process flowsheet was outlined and a preliminary economic feasibility study performed based on a process retrofit into Alcoa`s Arkansas tabular production facilities. Based on an assumed market demand of 20,000 mt/year and an assumed selling price of $0.65/lb (25% more than the current selling price of Tabular{trademark}, on a volume basis), economics were favorable. Decision on whether to proceed into Phase 3 (full- scale demonstration) will be based on a formal market survey in 1994 October.

  10. 12 CFR 725.5 - Capital stock.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Capital stock. 725.5 Section 725.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.5 Capital stock. (a) The capital stock of the Facility is...

  11. 12 CFR 725.5 - Capital stock.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Capital stock. 725.5 Section 725.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.5 Capital stock. (a) The capital stock of the Facility is...

  12. 12 CFR 725.5 - Capital stock.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Capital stock. 725.5 Section 725.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.5 Capital stock. (a) The capital stock of the Facility is...

  13. Measuring Social Capital in Hamilton, Ontario

    ERIC Educational Resources Information Center

    Kitchen, Peter; Williams, Allison; Simone, Dylan

    2012-01-01

    Social capital has been studied by academics for more than 20 years and within the past decade there has been an explosion of growth in research linking social capital to health. This paper investigates social capital in Hamilton, Ontario by way of a telephone survey of 1,002 households in three neighbourhood groups representing high, mixed and…

  14. School Social Capital and School Effectiveness

    ERIC Educational Resources Information Center

    Tsang, Kwok-Kuen

    2009-01-01

    This article argues that school social capital is crucial for school effectiveness, but it has been disregarded in the traditional school administrative theory. Therefore, this article tries to illustrate the significance of school social capital to school effectiveness. School social capital is defined as the social resources embedded in internal…

  15. 20 CFR 638.305 - Capital improvements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Capital improvements. 638.305 Section 638.305 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER....305 Capital improvements. Capital improvement projects and new construction on Job Corps Centers...

  16. 47 CFR 69.310 - Capital leases.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Capital leases. 69.310 Section 69.310 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES Apportionment of Net Investment § 69.310 Capital leases. Capital Leases in Account 2680 shall be...

  17. 47 CFR 32.4510 - Capital stock.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Capital stock. 32.4510 Section 32.4510... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.4510 Capital stock. (a... received for capital stock issued and outstanding. (b) Subsidiary records shall be maintained so as to...

  18. 47 CFR 32.4510 - Capital stock.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Capital stock. 32.4510 Section 32.4510... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.4510 Capital stock. (a... received for capital stock issued and outstanding. (b) Subsidiary records shall be maintained so as to...

  19. 20 CFR 638.305 - Capital improvements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Capital improvements. 638.305 Section 638.305 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER....305 Capital improvements. Capital improvement projects and new construction on Job Corps Centers...

  20. Natural Capital: Hard Economics, Soft Metaphor?

    ERIC Educational Resources Information Center

    Winnett, Adrian

    2005-01-01

    This paper views the concept of natural capital from an economist's perspective. It begins by drawing on historical debates in economics on the nature of capital. These serve to identify central issues to do with the relationship between theory, empirics and method in the way in which the concept of capital is deployed in economic discourse. It is…

  1. 12 CFR 615.5200 - Capital planning.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Capital planning. 615.5200 Section 615.5200... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Capital Adequacy § 615.5200 Capital planning. (a) The Board... provides for retirement or revolvement of equities included in core surplus, in connection with a...

  2. 12 CFR 615.5200 - Capital planning.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Capital planning. 615.5200 Section 615.5200 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Capital Adequacy § 615.5200 Capital planning. (a) The...

  3. Intergenerational Learning and Social Capital. ERIC Digest.

    ERIC Educational Resources Information Center

    Kerka, Sandra

    The concept of social capital refers to the resources of networks, norms or shared values, and trust to which individuals have access as community members. A reason to consider intergenerational learning in the context of social capital is awareness of unequal access to positive social capital and the risk that social exclusion and disadvantage…

  4. Venture Capital Initiative: Ohio's School Improvement Effort.

    ERIC Educational Resources Information Center

    Yoo, Soonhwa; Loadman, William E.

    In 1994 the Ohio State Legislature established Venture Capital to support school restructuring. The Venture Capital school initiative is a concept borrowed from the business community in which the corporate entity provides risk capital to parts of the organization to stimulate creative ideas and to provide opportunities for local entities to try…

  5. Steps for Launching a Capital Campaign.

    ERIC Educational Resources Information Center

    Safranek, Thomas W.; Usyk, Patricia A.

    The capital campaign in the Catholic elementary and secondary school must be viewed as an essential component in the total development program. This document addresses many of the specifics regarding the proper positioning steps and procedures for a capital campaign. The introductory chapter provides a historical overview of the capital campaign.…

  6. Sociospatial Schooling Practices: A Spatial Capital Approach

    ERIC Educational Resources Information Center

    Barthon, Catherine; Monfroy, Brigitte

    2010-01-01

    This paper highlights the importance today of the spatial dimension within the analysis of parents' education strategies concerning their school choices at the secondary school level. This study is based on the 2 dimensions of the concept of spatial capital (Levy, 1994): position capital and situation capital. It explores sociospatial schooling…

  7. 47 CFR 69.310 - Capital leases.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Capital leases. 69.310 Section 69.310 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES Apportionment of Net Investment § 69.310 Capital leases. Capital Leases in Account 2680 shall be...

  8. 47 CFR 32.2681 - Capital leases.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Capital leases. 32.2681 Section 32.2681... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.2681 Capital leases. (a) This account shall include all property acquired under a capital lease. A lease qualifies as a...

  9. Capital Financing for Independent Private Schools.

    ERIC Educational Resources Information Center

    Quinn, Kevin G.; Doherty, Robert F.; Wienk, Christopher O.

    This document contains summary materials from a presentation by Wye River Capital, Inc. of Annapolis, Maryland, on capital financing for independent private schools. The main sections of the presentation address: (1) overview of the capital financing process; (2) tax law considerations for tax-exempt financings by private schools; and (3) key…

  10. 75 FR 7339 - Secondary Capital Accounts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... capital (``SC'') from non-natural person members and nonmembers. 61 FR 50696 (Sept. 27, 1996). The Board intended that SC accounts provide LICUs with additional means to accumulate capital. 61 FR 3788 (Feb. 2, 1996); 71 FR 4234 (Jan. 26, 2006). Accumulated capital could be used to expand lending and...

  11. Human Capital Development: A Family Objective.

    ERIC Educational Resources Information Center

    Hildebrand, Verna

    1995-01-01

    Examines the concept of human capital as an economic construct. Suggests that human capital contributes to economic development, as do physical capital or natural resources, in that its development reinforces individuals' future economic output. Suggests that this perspective may prove useful for human service professionals because funding…

  12. Harnessing the Power of Intellectual Capital.

    ERIC Educational Resources Information Center

    Bassi, Laurie J.

    1997-01-01

    Describes intellectual capital--employees' brainpower, know-how, knowledge, and processes--and knowledge management--the processes by which a company creates and leverages intellectual capital--as the primary sources of competitive advantage in many industries. Offers ways to measure intellectual capital, a glossary, and additional resources. (JOW)

  13. Building Social Capital through Outdoor Education

    ERIC Educational Resources Information Center

    Beames, Simon; Atencio, Matthew

    2008-01-01

    Over the last 15 years, the body of literature surrounding the subject of social capital has witnessed steady growth. While sociologists have extensively discussed how social capital can be created and sustained within local communities and national contexts, there is little evidence of the social capital discourse within the outdoor education…

  14. Cognitive Capitalism, Education and Digital Labor

    ERIC Educational Resources Information Center

    Peters, Michael A., Ed.; Bulut, Ergin, Ed.

    2011-01-01

    Cognitive capitalism--sometimes referred to as "third capitalism," after mercantilism and industrial capitalism--is an increasingly significant theory, given its focus on the socio-economic changes caused by Internet and Web 2.0 technologies that have transformed the mode of production and the nature of labor. The theory of cognitive capitalism…

  15. Neighborhood social capital and crime victimization: comparison of spatial regression analysis and hierarchical regression analysis.

    PubMed

    Takagi, Daisuke; Ikeda, Ken'ichi; Kawachi, Ichiro

    2012-11-01

    Crime is an important determinant of public health outcomes, including quality of life, mental well-being, and health behavior. A body of research has documented the association between community social capital and crime victimization. The association between social capital and crime victimization has been examined at multiple levels of spatial aggregation, ranging from entire countries, to states, metropolitan areas, counties, and neighborhoods. In multilevel analysis, the spatial boundaries at level 2 are most often drawn from administrative boundaries (e.g., Census tracts in the U.S.). One problem with adopting administrative definitions of neighborhoods is that it ignores spatial spillover. We conducted a study of social capital and crime victimization in one ward of Tokyo city, using a spatial Durbin model with an inverse-distance weighting matrix that assigned each respondent a unique level of "exposure" to social capital based on all other residents' perceptions. The study is based on a postal questionnaire sent to 20-69 years old residents of Arakawa Ward, Tokyo. The response rate was 43.7%. We examined the contextual influence of generalized trust, perceptions of reciprocity, two types of social network variables, as well as two principal components of social capital (constructed from the above four variables). Our outcome measure was self-reported crime victimization in the last five years. In the spatial Durbin model, we found that neighborhood generalized trust, reciprocity, supportive networks and two principal components of social capital were each inversely associated with crime victimization. By contrast, a multilevel regression performed with the same data (using administrative neighborhood boundaries) found generally null associations between neighborhood social capital and crime. Spatial regression methods may be more appropriate for investigating the contextual influence of social capital in homogeneous cultural settings such as Japan. PMID

  16. Assessing relationships among properties of demolished concrete, recycled aggregate and recycled aggregate concrete using regression analysis.

    PubMed

    Tam, Vivian W Y; Wang, K; Tam, C M

    2008-04-01

    Recycled demolished concrete (DC) as recycled aggregate (RA) and recycled aggregate concrete (RAC) is generally suitable for most construction applications. Low-grade applications, including sub-base and roadwork, have been implemented in many countries; however, higher-grade activities are rarely considered. This paper examines relationships among DC characteristics, properties of their RA and strength of their RAC using regression analysis. Ten samples collected from demolition sites are examined. The results show strong correlation among the DC samples, properties of RA and RAC. It should be highlighted that inferior quality of DC will lower the quality of RA and thus their RAC. Prediction of RAC strength is also formulated from the DC characteristics and the RA properties. From that, the RAC performance from DC and RA can be estimated. In addition, RAC design requirements can also be developed at the initial stage of concrete demolition. Recommendations are also given to improve the future concreting practice. PMID:17764837

  17. Agrofuels capitalism: a view from political economy.

    PubMed

    White, Ben; Dasgupta, Anirban

    2010-01-01

    This article considers the global expansion of agrofuels feedstock production from a political economy perspective. It considers and dismisses the environmental and pro-poor developmental justifications attached to agrofuels. To local populations and direct producers, the specific destination of the crop as fuel, food, cosmetics or other final uses in faraway places is probably of less interest than the forms of (direct or indirect) appropriation of their land and the forms of their insertion or exclusion as producers in global commodity chains. Global demand for both agrofuels and food is stimulating new forms (or the resurgence of old forms) of corporate land grabbing and expropriation, and of incorporation of smallholders in contracted production. Drawing both on recent studies on agrofuels expansion and on the political economy literature on agrarian transition and capitalism in agriculture, this article raises the question whether "agrofuels capitalism" is in any way essentially different from other forms of capitalist agrarian monocrop production, and in turn whether the agrarian transitions involved require new tools of analysis. PMID:20873026

  18. Measuring Social Capital Investment: Scale Development and Examination of Links to Social Capital and Perceived Stress

    PubMed Central

    Wegner, Rhiana; Gong, Jie; Fang, Xiaoyi; Kaljee, Linda

    2014-01-01

    Individuals with greater social capital have better health outcomes. Investment in social capital likely increases one’s own social capital, bearing great implications for disease prevention and health promotion. In this study, the authors developed and validated the Social Capital Investment Inventory (SCII). Direct effects of social capital investment on perceived stress, and indirect effects through social capital were examined. 397 Participants from Beijing and Wuhan, China completed surveys. Analyses demonstrated that the SCII has a single factor structure and strong internal consistency. Structural equation modeling showed that individuals who invested more in social capital had greater bonding social capital, and subsequently less perceived stress. Results suggest that disease prevention and health promotion programs should consider approaches to encourage social capital investment; individuals may be able to reduce stress by increasing their investment in social capital. Future research is needed to provide additional empirical support for the SCII and observed structural relationships. PMID:25648725

  19. The Influence of Fisher Knowledge on the Susceptibility of Reef Fish Aggregations to Fishing

    PubMed Central

    Robinson, Jan; Cinner, Joshua E.; Graham, Nicholas A. J.

    2014-01-01

    Reef fishes that exhibit predictable aggregating behaviour are often considered vulnerable to overexploitation. However, fisher knowledge of this behaviour is often heterogeneous and, coupled with socioeconomic factors that constrain demand for or access to aggregated fish, will influence susceptibility to fishing. At two case study locations in Papua New Guinea, Ahus and Karkar islands, we conducted interview-based surveys to examine how local context influenced heterogeneity in knowledge of fish aggregations. We then explored the role of fisher knowledge in conferring susceptibility to fishing relative to socioeconomic drivers of fishing effort. Local heterogeneity in knowledge of aggregating behaviour differed between our case studies. At Ahus, variable access rights among fishers and genders to the main habitats were sources of heterogeneity in knowledge. By contrast, knowledge was more homogenous at Karkar and the sole source of variation was gear type. Differences between locations in the susceptibility of aggregations to fishing depended primarily on socioeconomic drivers of fishing effort rather than catchability. While Ahus fishers were knowledgeable of fish aggregations and used more selective gears, Karkar fishers were less constrained by tenure in their access to aggregation habitat. However, fishing effort was greater at Ahus and likely related to high dependency on fishing, greater access to provincial capital markets than Karkar and a weakening of customary management. Moreover, highly efficient fishing techniques have emerged at Ahus to exploit the non-reproductive aggregating behaviour of target species. Understanding how knowledge is structured within fishing communities and its relation to socioeconomic drivers of fishing effort is important if customary practices for conservation, such as tambu areas, are to be supported. The findings of this study call for a holistic approach to assessing the risks posed to reef fish aggregations by fishing

  20. The influence of fisher knowledge on the susceptibility of reef fish aggregations to fishing.

    PubMed

    Robinson, Jan; Cinner, Joshua E; Graham, Nicholas A J

    2014-01-01

    Reef fishes that exhibit predictable aggregating behaviour are often considered vulnerable to overexploitation. However, fisher knowledge of this behaviour is often heterogeneous and, coupled with socioeconomic factors that constrain demand for or access to aggregated fish, will influence susceptibility to fishing. At two case study locations in Papua New Guinea, Ahus and Karkar islands, we conducted interview-based surveys to examine how local context influenced heterogeneity in knowledge of fish aggregations. We then explored the role of fisher knowledge in conferring susceptibility to fishing relative to socioeconomic drivers of fishing effort. Local heterogeneity in knowledge of aggregating behaviour differed between our case studies. At Ahus, variable access rights among fishers and genders to the main habitats were sources of heterogeneity in knowledge. By contrast, knowledge was more homogenous at Karkar and the sole source of variation was gear type. Differences between locations in the susceptibility of aggregations to fishing depended primarily on socioeconomic drivers of fishing effort rather than catchability. While Ahus fishers were knowledgeable of fish aggregations and used more selective gears, Karkar fishers were less constrained by tenure in their access to aggregation habitat. However, fishing effort was greater at Ahus and likely related to high dependency on fishing, greater access to provincial capital markets than Karkar and a weakening of customary management. Moreover, highly efficient fishing techniques have emerged at Ahus to exploit the non-reproductive aggregating behaviour of target species. Understanding how knowledge is structured within fishing communities and its relation to socioeconomic drivers of fishing effort is important if customary practices for conservation, such as tambu areas, are to be supported. The findings of this study call for a holistic approach to assessing the risks posed to reef fish aggregations by fishing

  1. Patterning microparticles on a template of aggregated cationic dye.

    PubMed

    Wexler, Allan; Switalski, Steven; Bennett, Grace; Lindner, Kimberly; Baptiste, Kenny; Slater, Gary

    2015-02-01

    Patternwise aggregation of charged molecules on a surface is potentially a facile approach to generate a template on which to pattern oppositely charged microparticles. We report on the patterning of silica microparticles by a system comprising a photopatternable copolymer and an aggregate forming penta-cationic cyanine dye. A thin film of the copolymer, composed of a molar excess of styrenesulfonic acid oxime ester to cross-linkable glycidyl methacrylate monomomers, was exposed through a mask and neutralized, resulting in a pattern of hydrophobic areas, and where exposed, a hydrophilic cross-linked film with sodium poly(styrenesulfonate) domains. The occurrence and locus of aggregation of an aqueous solution of the dye, applied to the patterned surface was established by absorbance and fluorescence spectroscopy and atomic force microscopy. In exposed areas, dye is imbibed and aggregation induced in sodium styrenesulfonate domains internal to the layer, whereas in the unexposed areas the dye aggregates on the hydrophobic surface. Aqueous anionic silica microparticles applied to the dye treated patterned surface and then rinsed, are retained in the unexposed areas having cationic surface aggregates, but rejected from the exposed areas with internal dye aggregates as these areas retain net negative charge. Mask exposure, absent dye treatment, did not result in patterning as negatively charged microparticles were nowhere retained, and positively charged particles were everywhere retained. The extent of surface coverage by the dye in unexposed areas was deposition time dependent, and ranged from isolated patches covering about 20 percent of the polymer surface to a surface saturated layer, with silica particle patterning robust over the range of dye surface coverages studied. The force requirements to pattern the denser than water silica microparticles are identified, and particle and polymer film surface potentials that meet the critical repulsion force requirement

  2. Mesoscale Simulation of Asphaltene Aggregation.

    PubMed

    Wang, Jiang; Ferguson, Andrew L

    2016-08-18

    Asphaltenes constitute a heavy aromatic crude oil fraction with a propensity to aggregate and precipitate out of solution during petroleum processing. Aggregation is thought to proceed according to the Yen-Mullins hierarchy, but the molecular mechanisms underlying mesoscopic assembly remain poorly understood. By combining coarse-grained molecular models parametrized using all-atom data with high-performance GPU hardware, we have performed molecular dynamics simulations of the aggregation of hundreds of asphaltenes over microsecond time scales. Our simulations reveal a hierarchical self-assembly mechanism consistent with the Yen-Mullins model, but the details are sensitive and depend on asphaltene chemistry and environment. At low concentrations asphaltenes exist predominantly as dispersed monomers. Upon increasing concentration, we first observe parallel stacking into 1D rod-like nanoaggregates, followed by the formation of clusters of nanoaggregates associated by offset, T-shaped, and edge-edge stacking. Asphaltenes possessing long aliphatic side chains cannot form nanoaggregate clusters due to steric repulsions between their aliphatic coronae. At very high concentrations, we observe a porous percolating network of rod-like nanoaggregates suspended in a sea of interpenetrating aliphatic side chains with a fractal dimension of ∼2. The lifetime of the rod-like aggregates is described by an exponential distribution reflecting a dynamic equilibrium between coagulation and fragmentation. PMID:27455391

  3. RAGG - R EPISODIC AGGREGATION PACKAGE

    EPA Science Inventory

    The RAGG package is an R implementation of the CMAQ episodic model aggregation method developed by Constella Group and the Environmental Protection Agency. RAGG is a tool to provide climatological seasonal and annual deposition of sulphur and nitrogen for multimedia management. ...

  4. An Aggregation Advisor for Ligand Discovery.

    PubMed

    Irwin, John J; Duan, Da; Torosyan, Hayarpi; Doak, Allison K; Ziebart, Kristin T; Sterling, Teague; Tumanian, Gurgen; Shoichet, Brian K

    2015-09-10

    Colloidal aggregation of organic molecules is the dominant mechanism for artifactual inhibition of proteins, and controls against it are widely deployed. Notwithstanding an increasingly detailed understanding of this phenomenon, a method to reliably predict aggregation has remained elusive. Correspondingly, active molecules that act via aggregation continue to be found in early discovery campaigns and remain common in the literature. Over the past decade, over 12 thousand aggregating organic molecules have been identified, potentially enabling a precedent-based approach to match known aggregators with new molecules that may be expected to aggregate and lead to artifacts. We investigate an approach that uses lipophilicity, affinity, and similarity to known aggregators to advise on the likelihood that a candidate compound is an aggregator. In prospective experimental testing, five of seven new molecules with Tanimoto coefficients (Tc's) between 0.95 and 0.99 to known aggregators aggregated at relevant concentrations. Ten of 19 with Tc's between 0.94 and 0.90 and three of seven with Tc's between 0.89 and 0.85 also aggregated. Another three of the predicted compounds aggregated at higher concentrations. This method finds that 61 827 or 5.1% of the ligands acting in the 0.1 to 10 μM range in the medicinal chemistry literature are at least 85% similar to a known aggregator with these physical properties and may aggregate at relevant concentrations. Intriguingly, only 0.73% of all drug-like commercially available compounds resemble the known aggregators, suggesting that colloidal aggregators are enriched in the literature. As a percentage of the literature, aggregator-like compounds have increased 9-fold since 1995, partly reflecting the advent of high-throughput and virtual screens against molecular targets. Emerging from this study is an aggregator advisor database and tool ( http://advisor.bkslab.org ), free to the community, that may help distinguish between

  5. Program of Requirements Guidelines.

    ERIC Educational Resources Information Center

    Council of Educational Facility Planners, International, Columbus, OH.

    These guidelines describe both the role and preparation of a Program of Requirements (POR) in the planning and design of capital improvements projects. The purpose of POR is to define very clearly facility needs and objectives to the designer. The POR consists of five parts: (l) the title page; (2) part A, a summary of the project and general…

  6. Effects of iron-aluminium oxides and organic carbon on aggregate stability of bauxite residues.

    PubMed

    Zhu, Feng; Li, Yubing; Xue, Shengguo; Hartley, William; Wu, Hao

    2016-05-01

    In order to successfully establish vegetation on bauxite residue, properties such as aggregate structure and stability require improvement. Spontaneous plant colonization on the deposits in Central China over the last 20 years has revealed that natural processes may improve the physical condition of bauxite residues. Samples from three different stacking ages were selected to determine aggregate formation and stability and its relationship with iron-aluminium oxides and organic carbon. The residue aggregate particles became coarser in both dry and wet sieving processes. The mean weight diameter (MWD) and geometry mean diameter (GMD) increased significantly, and the proportion of aggregate destruction (PAD) decreased. Natural stacking processes could increase aggregate stability and erosion resistant of bauxite residues. Free iron oxides and amorphous aluminium oxides were the major forms in bauxite residues, but there was no significant correlation between the iron-aluminium oxides and aggregate stability. Aromatic-C, alkanes-C, aliphatic-C and alkenes-C were the major functional groups present in the residues. With increasing stacking age, total organic carbon content and aggregate-associated organic carbon both increased. Alkanes-C, aliphatic-C and alkenes-C increased and were mainly distributed in macro-aggregates, whereas aromatic-C was mainly distributed in <0.05-mm aggregates. Organic carbon stability in micro-aggregates was higher than that in macro-aggregates and became more stable. Organic carbon contents in total residues, and within different aggregate sizes, were all negatively correlated with PAD. It indicated that organic materials had a more significant effect on macro-aggregate stability and the effects of iron-aluminium oxides maybe more important for stability of micro-aggregates. PMID:26832865

  7. Effect of protein-surfactant interactions on aggregation of β-lactoglobulin.

    PubMed

    Hansted, Jon G; Wejse, Peter L; Bertelsen, Hans; Otzen, Daniel E

    2011-05-01

    The milk protein β-lactoglobulin (βLG) dominates the properties of whey aggregates in food products. Here we use spectroscopic and calorimetric techniques to elucidate how anionic, cationic and non-ionic surfactants interact with bovine βLG and modulate its heat-induced aggregation. Alkyl trimethyl ammonium chlorides (xTAC) strongly promote aggregation, while sodium alkyl sulfates (SxS) and alkyl maltopyranosides (xM) reduce aggregation. Sodium dodecyl sulfate (SDS) binds to non-aggregated βLG in several steps, but reduction of aggregation was associated with the first binding step, which occurs far below the critical micelle concentration. In contrast, micellar concentrations of xMs are required to reduce aggregation. The ranking order for reduction of aggregation (normalized to their tendency to self-associate) was C10-C12>C8>C14 for SxS and C8>C10>C12>C14>C16 for xM. xTAC promote aggregation in the same ranking order as xM reduce it. We conclude that SxS reduce aggregation by stabilizing the protein's ligand-bound state (the melting temperature t(m) increases by up to 10°C) and altering its charge potential. xM monomers also stabilize the protein's ligand-bound state (increasing t(m) up to 6°C) but in the absence of charged head groups this is not sufficient by itself to prevent aggregation. Although micelles of both anionic and non-ionic surfactants destabilize βLG, they also solubilize unfolded protein monomers, leaving them unavailable for protein-protein association and thus inhibiting aggregation. Cationic surfactants promote aggregation by a combination of destabilization and charge neutralization. The food compatible surfactant sodium dodecanoate also inhibited aggregation well below the cmc, suggesting that surfactants may be a practical way to modulate whey protein properties. PMID:21440683

  8. How to choose the right capitalization option.

    PubMed

    Vaughan, J; Wise, J

    1996-12-01

    Physician group practices and networks must have ready access to capital to finance their working capital needs, capital equipment acquisitions, and real estate purchases, as well as to fund the acquisition of additional practices. At least three options for capitalization are available to group practices and networks: debt financing, equity financing, or a combination of the two. The best option for physician group practices and networks depends on the costs of capital and the impact the strategy will have on decision making and governance. PMID:10163009

  9. The Case for Capitation.

    PubMed

    James, Brent C; Poulsen, Gregory P

    2016-01-01

    Recent studies suggest that at least 35%--and maybe over 5o%--of all health care spending in the U.S. is wasted on inadequate, unnecessary, and inefficient care and suboptimal business processes. But efforts to get rid of that waste face a huge challenge: Under current payment methods, the providers who develop more-cost-effective approaches don't receive any of the savings. Instead, the money goes mainly to insurers. The providers, who are paid for the volume of services delivered, end up actually losing money, which undermines their finances and their ability to invest in more cost-saving innovations. To address this quandary, say two top execs from the nonprofit Intermountain Healthcare system, we need a different way to pay for health care: population-based payment. PBP gives care delivery groups a fixed per-person payment that covers all of an individual's health care services in a given year. Under it, providers benefit from the savings of all efforts to attack waste, encouraging them to do it more. And though PBP may sound similar to the HMOs of the 1990s, there are significant twists: Payments go directly to care delivery groups, and patients' physicians--not insurance companies--assume responsibility for overseeing and managing the cost of treatment. Provider groups are also required to meet quality standards that further protect patients. By applying PBP in just part of its system, Intermountain, which serves 2 million people, has been able to chop $688 million in annual waste and bring total costs down 13%. PMID:27526566

  10. 17 CFR 240.15c3-1b - Adjustments to net worth and aggregate indebtedness for certain commodities transactions...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). 240.15c3-1b... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). (a) Every broker or dealer in computing net capital pursuant to 17 CFR 240.15c3-1 shall comply with the...

  11. 17 CFR 240.15c3-1b - Adjustments to net worth and aggregate indebtedness for certain commodities transactions...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). 240.15c3-1b... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). (a) Every broker or dealer in computing net capital pursuant to 17 CFR 240.15c3-1 shall comply with the...

  12. 17 CFR 240.15c3-1b - Adjustments to net worth and aggregate indebtedness for certain commodities transactions...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). 240.15c3-1b... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). (a) Every broker or dealer in computing net capital pursuant to 17 CFR 240.15c3-1 shall comply with the...

  13. 17 CFR 240.15c3-1b - Adjustments to net worth and aggregate indebtedness for certain commodities transactions...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... aggregate indebtedness for certain commodities transactions (appendix B to 17 CFR 240.15c3-1). 240.15c3-1b... aggregate indebtedness for certain commodities transactions (appendix B to 17 CFR 240.15c3-1). (a) Every broker or dealer in computing net capital pursuant to 17 CFR 240.15c3-1 shall comply with the...

  14. 17 CFR 240.15c3-1b - Adjustments to net worth and aggregate indebtedness for certain commodities transactions...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). 240.15c3-1b... aggregate indebtedness for certain commodities transactions (Appendix B to 17 CFR 240.15c3-1). (a) Every broker or dealer in computing net capital pursuant to 17 CFR 240.15c3-1 shall comply with the...

  15. Capital, population and urban patterns.

    PubMed

    Zhang, W

    1994-04-01

    The author develops an approach to urban dynamics with endogenous capital and population growth, synthesizing the Alonso location model, the two-sector neoclassical growth model, and endogenous population theory. A dynamic model for an isolated island economy with endogenous capital, population, and residential structure is developed on the basis of Alonso's residential model and the two-sector neoclassical growth model. The model describes the interdependence between residential structure, economic growth, population growth, and economic structure over time and space. It has a unique long-run equilibrium, which may be either stable or unstable, depending upon the population dynamics. Applying the Hopf theorem, the author also shows that when the system is unstable, the economic geography exhibits permanent endogenous oscillations. PMID:12346957

  16. Trends in U.S. Venture Capital Investments Related to Energy: 1980 through the Third Quarter of 2010

    SciTech Connect

    Dooley, James J.

    2010-11-08

    This report documents trends in U.S. venture capital investments over the period 1980 through the third quarter of calendar year 2010 (2010 Q1+Q2+Q3). Particular attention is given to U.S. venture capital investments in the energy/industrial sector over the period 1980-2010 Q1+Q2+Q3 as well as in the more recently created cross-cutting category of CleanTech over the period 1995-2010 Q1+Q2+Q3. During the early 1980s, U.S. venture capital investments in the energy/industrial sector accounted for more than 20% of all venture capital investments. However subsequent periods of low energy prices, the deregulation of large aspects of the energy industry, and the emergence of fast growing new industries like computers (both hardware and software), biotechnology and the Internet quickly reduced the priority accorded to energy/industrial investments. To wit, venture capital investments related to the energy/industrial sector accounted for only 1% of the $132 billion (in real 2010 US$) invested in 2000 by the U.S. venture capital community. The significant increase in the real price of oil that began in 2003-2004 correlates with renewed interest and increased investment by the venture capital community in energy/industrial investment opportunities. Venture capital investments for 2009 for the energy/industrial sector accounted for $2.4 billion or slightly more than 13% of all venture capital invested that year. The total venture capital invested in energy/industrial during the first three quarters of 2010 is close to $2.4 billion accounting for slightly less than 15% of all venture capital investments during the first three quarters of 2010. In 2009, the aggregate amount invested in CleanTech was $2.1 billion (11% of the total US venture capital invested in that lean year) and for the first three quarters of 2010 US venture capital investments in CleanTech have already exceeded $2.8 billion (18% of all US venture capital investments made during the first three quarters of

  17. Trends in U.S. Venture Capital Investments Related to Energy: 1980 through the Second Quarter of 2010

    SciTech Connect

    Dooley, James J.

    2010-07-29

    This report documents trends in U.S. venture capital investments over the period 1980 through the second quarter of calendar year 2010 (2010Q1+Q2). Particular attention is given to U.S. venture capital investments in the energy/industrial sector over the period 1980-2010Q1+Q2 as well as in the more recently created cross-cutting category of CleanTech over the period 1995-2010Q1+Q2. During the early 1980s, U.S. venture capital investments in the energy/industrial sector accounted for more than 20% of all venture capital investments. However subsequent periods of low energy prices, the deregulation of large aspects of the energy industry, and the emergence of fast growing new industries like computers (both hardware and software), biotechnology and the Internet quickly reduced the priority accorded to energy/industrial investments. To wit, venture capital investments related to the energy/industrial sector accounted for only 1% of the $119 billion dollars invested in 2000 by the U.S. venture capital community. The significant increase in the real price of oil that began in 2003-2004 correlates with renewed interest and increased investment by the venture capital community in energy/industrial investment opportunities. Venture capital investments for 2009 for the energy/industrial sector accounted for $2.1 billion or slightly more than 13% of all venture capital invested that year. The total venture capital invested in energy/industrial during the first two quarters of 2010 is close to $1.8 billion accounting for 17% of all venture capital investments during the first two quarters of 2010. In 2009, the aggregate amount invested in CleanTech was $1.8 billion (30% of the total US venture capital invested in that lean year) and for the first two quarters of 2010 US venture capital investments in CleanTech have already exceeded $1.9 billion (19% of all US venture capital investments made during the first half of 2010). Between 2004 and 2009, U.S. venture capital

  18. 26 CFR 1.415(f)-1 - Aggregating plans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... limitation year— (1) All defined benefit plans (without regard to whether a plan has been terminated) ever... required to be aggregated pursuant to section 415(f) and this section in a plan year. Paragraph (e)(3) of... specifically mentioned in the example), and the limitation year for each qualified plan is the calendar...

  19. 26 CFR 1.415(f)-1 - Aggregating plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... limitation year— (1) All defined benefit plans (without regard to whether a plan has been terminated) ever... required to be aggregated pursuant to section 415(f) and this section in a plan year. Paragraph (e)(3) of... specifically mentioned in the example), and the limitation year for each qualified plan is the calendar...

  20. HESI EXPOSURE FACTORS DATABASE FOR AGGREGATE AND CUMULATIVE RISK ASSESSMENT

    EPA Science Inventory

    In recent years, the risk analysis community has broadened its use of complex aggregate and cumulative residential exposure models (e.g., to meet the requirements of the 1996 Food Quality Protection Act). The value of these models is their ability to incorporate a range of inp...

  1. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... non-combustion control device, whichever is less stringent, on a continuous basis. (2) The owner or... non-combustion control device, whichever is less stringent, on a continuous basis. (b) Alternative... from all aggregate batch vent streams in the compliance demonstration required for reactor...

  2. Production of lightweight aggregates from washing aggregate sludge and fly ash

    NASA Astrophysics Data System (ADS)

    González-Corrochano, Beatriz; Alonso-Azcárate, Jacinto; Rodas, Magdalena

    2010-05-01

    Increasing generation of wastes is one of the main environmental problems in industrialised countries. Heat treatment at high temperatures can convert some types of wastes into ceramic products with a wide range of microstructural features and properties (Bethanis et al., 2004). A lightweight aggregate (LWA) is a granular material with a bulk density (bd) not exceeding 1.20 g/cm3 or with a particle density not exceeding 2.00 g/cm3 (UNE-EN-13055-1, 2003). They have become a focus of interest because the low particle density and the low bulk density entail a decrease in the load transmitted to the ground, and less work and effort are required to transport them (De' Gennaro et al., 2004). The benefits associated with these low densities, which are due to the formation of voids and pores, are very good thermal and acoustic insulation and materials with a good resistance to fire (Benbow, 1987; Fakhfakh et al., 2007). The objective was to recycle fly ash, used motor oil from cars and mineral wastes from washing aggregate sludge, in order to obtain a usable material such as lightweight aggregates, and also to ensure that they are of good quality for different applications. Raw materials have been physically, chemically and mineralogically characterized. On the basis of the results obtained, they were mixed, milled to a grain size of less than 200 μm (Yasuda, 1991), formed into pellets, pre-heated for 5 min and sintered in a rotary kiln at 1150°C, 1175°C, 1200°C and 1225°C for 10 and 15 min at each temperature (Theating). Effects of raw material characteristics, heating temperature and dwell time on the following LWAs properties were determined: loss on ignition (LOI), bloating index (BI), loose bulk density (bd), apparent and dry particle density (ad, dd), voids (H), water absorption (WA24h) and compressive strength (S). The products obtained were lightweight aggregates in accordance with norm UNE-EN-13055-1 (bd ≤1.20 g/cm3 or particle density ≤2.00 g/cm3). LWAs

  3. Privacy-Preserving Data Aggregation Protocols for Wireless Sensor Networks: A Survey

    PubMed Central

    Bista, Rabindra; Chang, Jae-Woo

    2010-01-01

    Many wireless sensor network (WSN) applications require privacy-preserving aggregation of sensor data during transmission from the source nodes to the sink node. In this paper, we explore several existing privacy-preserving data aggregation (PPDA) protocols for WSNs in order to provide some insights on their current status. For this, we evaluate the PPDA protocols on the basis of such metrics as communication and computation costs in order to demonstrate their potential for supporting privacy-preserving data aggregation in WSNs. In addition, based on the existing research, we enumerate some important future research directions in the field of privacy-preserving data aggregation for WSNs. PMID:22399893

  4. Modulus enhancement of natural rubber through the dispersion size reduction of protein/fiber aggregates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Improved mechanical properties of natural rubber are required for various rubber applications. Aggregates of protein and fiber that constitute soy protein concentrate were shear-reduced and used to enhance the tensile modulus of natural rubber. The aqueous dispersion of the shear-reduced aggregates ...

  5. Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

    PubMed Central

    Zhang, Ying; Rempel, Don L.; Zhang, Jun; Sharma, Anuj K.; Mirica, Liviu M.; Gross, Michael L.

    2013-01-01

    Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates. To investigate the formation of these aggregates in solution, we designed an MS-based biophysical approach and applied it to the formation of soluble aggregates of the Aβ42 peptide, the proposed causative agent in Alzheimer’s disease. The approach incorporates pulsed hydrogen–deuterium exchange coupled with MS analysis. The combined approach provides evidence for a self-catalyzed aggregation with a lag phase, as observed previously by fluorescence methods. Unlike those approaches, pulsed hydrogen–deuterium exchange does not require modified Aβ42 (e.g., labeling with a fluorophore). Furthermore, the approach reveals that the center region of Aβ42 is first to aggregate, followed by the C and N termini. We also found that the lag phase in the aggregation of soluble species is affected by temperature and Cu2+ ions. This MS approach has sufficient structural resolution to allow interrogation of Aβ aggregation in physiologically relevant environments. This platform should be generally useful for investigating the aggregation of other amyloid-forming proteins and neurotoxic soluble peptide aggregates. PMID:23959898

  6. Bacterial colonization and extinction on marine aggregates: stochastic model of species presence and abundance

    PubMed Central

    Kramer, Andrew M; Lyons, M Maille; Dobbs, Fred C; Drake, John M

    2013-01-01

    Organic aggregates provide a favorable habitat for aquatic microbes, are efficiently filtered by shellfish, and may play a major role in the dynamics of aquatic pathogens. Quantifying this role requires understanding how pathogen abundance in the water and aggregate size interact to determine the presence and abundance of pathogen cells on individual aggregates. We build upon current understanding of the dynamics of bacteria and bacterial grazers on aggregates to develop a model for the dynamics of a bacterial pathogen species. The model accounts for the importance of stochasticity and the balance between colonization and extinction. Simulation results suggest that while colonization increases linearly with background density and aggregate size, extinction rates are expected to be nonlinear on small aggregates in a low background density of the pathogen. Under these conditions, we predict lower probabilities of pathogen presence and reduced abundance on aggregates compared with predictions based solely on colonization. These results suggest that the importance of aggregates to the dynamics of aquatic bacterial pathogens may be dependent on the interaction between aggregate size and background pathogen density, and that these interactions are strongly influenced by ecological interactions and pathogen traits. The model provides testable predictions and can be a useful tool for exploring how species-specific differences in pathogen traits may alter the effect of aggregates on disease transmission. PMID:24340173

  7. Hydrolysis of whey protein isolate with Bacillus licheniformis protease: aggregating capacities of peptide fractions.

    PubMed

    Creusot, Nathalie; Gruppen, Harry

    2008-11-12

    In a previous study, peptides aggregating at pH 7.0 derived from a whey protein hydrolysate made with Bacillus licheniformis protease were fractionated and identified. The objective of the present work was to investigate the solubility of the fractionated aggregating peptides, as a function of concentration, and their aggregating capacities toward added intact proteins. The amount of aggregated material and the composition of the aggregates obtained were measured by nitrogen concentration and size exclusion chromatography, respectively. The results showed that of the four fractions obtained from the aggregating peptides, two were insoluble, while the other two consisted of 1:1 mixture of low and high solubility peptides. Therefore, insoluble peptides coaggregated, assumedly via hydrophobic interactions, other relatively more soluble peptides. It was also shown that aggregating peptides could aggregate intact protein nonspecifically since the same peptides were involved in the aggregation of whey proteins, beta-casein, and bovine serum albumin. Both insoluble and partly insoluble peptides were required for the aggregation of intact protein. These results are of interest for the applications of protein hydrolysates, as mixtures of intact protein and peptides are often present in these applications. PMID:18922012

  8. Hierarchical Clustering and Visualization of Aggregate Cyber Data

    SciTech Connect

    Patton, Robert M; Beaver, Justin M; Steed, Chad A; Potok, Thomas E; Treadwell, Jim N

    2011-01-01

    Most commercial intrusion detections systems (IDS) can produce a very high volume of alerts, and are typically plagued by a high false positive rate. The approach described here uses Splunk to aggregate IDS alerts. The aggregated IDS alerts are retrieved from Splunk programmatically and are then clustered using text analysis and visualized using a sunburst diagram to provide an additional understanding of the data. The equivalent of what the cluster analysis and visualization provides would require numerous detailed queries using Splunk and considerable manual effort.

  9. Aggregation of metallochlorophylls - Examination by spectroscopy

    NASA Technical Reports Server (NTRS)

    Boucher, L. J.; Katz, J. J.

    1969-01-01

    Nuclear magnetic resonance measurements determine which metallochlorophylls, besides magnesium-containing chlorophylls, possess coordination aggregation properties. Infrared spectroscopy reveals that only zinc pheophytin and zinc methyl pheophorbide showed significant coordination aggregation, whereas divalent nickel and copper did not.

  10. Oligomeric baroeffect and gas aggregation states

    NASA Technical Reports Server (NTRS)

    Noever, David A.

    1992-01-01

    The baroeffect is analyzed to include a gas that aggregates into higher-order polymers or oligomers. The resulting pressure change is found to vary independently of the molecular weight of the gas components and to depend only on the aggregation or oligomeric order of the gas. With increasing aggregation, diffusive slip velocities are found to increase. The calculations are extended to include general counterdiffusion of two distinct aggregation states (k-, j-mer) for the gas, and the pressure change is derived as a function that is independent of both molecular weight and the absolute aggregation. The only parameter that determines the baroeffect is the ratio of aggregated states, beta = k/j. For gases that reversibly aggregate, possible oscillatory behavior and complex dynamics for pressure are discussed. Gas aggregation may play a role for low-temperature crystal-growth conditions in which vapor concentrations of one (or more) species are high.

  11. 42 CFR 412.46 - Medical review requirements: Physician acknowledgement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES... Capital-Related Costs § 412.46 Medical review requirements: Physician acknowledgement. (a) Basis....

  12. Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

    PubMed Central

    Pearce, Margaret M.P.; Spartz, Ellen J.; Hong, Weizhe; Luo, Liqun; Kopito, Ron R.

    2015-01-01

    The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. We have established a Drosophila model to investigate the role of phagocytic glia in clearance of neuronal mutant huntingtin (Htt) aggregates associated with Huntington disease. We find that glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic machinery. Remarkably, some of these engulfed neuronal Htt aggregates effect prion-like conversion of soluble, wild-type Htt in the glial cytoplasm. We provide genetic evidence that this conversion depends strictly on the Draper signaling pathway, unveiling a previously unanticipated role for phagocytosis in transfer of pathogenic protein aggregates in an intact brain. These results suggest a potential mechanism by which phagocytic glia contribute to both protein aggregate-related neuroprotection and pathogenesis in neurodegenerative disease. PMID:25866135

  13. Identifying and Removing Barriers to Expanding Municipal Aggregation in the Commonwealth

    NASA Astrophysics Data System (ADS)

    Morrill, Micaelah Burke

    This thesis examines the process to become a municipal aggregator in Massachusetts and offers recommendations on improving the process. In 1997, the Commonwealth of Massachusetts restructured its electricity market and allowed municipalities and those working jointly to purchase electricity for their constituents. Municipal aggregators provide additional competition in the electricity market, public control of electricity purchases, and are in a unique position to provide consumers additional options to promote specific types of electricity generation. Since 1997, only six municipal aggregators have been approved in Massachusetts. In order to identify reasons why, this thesis includes interviews with people involved in the municipal aggregation process in Massachusetts and comparisons with other states that also have municipal aggregation programs. It also includes a historical look at electricity markets both on the federal level and in Massachusetts, and provides information on regulatory requirements municipal aggregators must meet.

  14. Poor people, poor places, and poor health: the mediating role of social networks and social capital.

    PubMed

    Cattell, V

    2001-05-01

    This paper explores the dynamics between poverty and exclusion; neighbourhood, and health and well being by considering the role of social networks and social capital in the social processes involved. It is based on qualitative research taking two deprived areas as exemplary case studies, and involving depth interviews with residents. Neighbourhood influences on networks and social capital were explored, network typologies developed reflecting structural and cultural aspects of individual's networks, and pathways implicated in health effects considered. The complexity of social capital is addressed. The role of three factors in influencing social networks and social capital are demonstrated: neighbourhood characteristics and perceptions; poverty and social exclusion, and social consciousness. Perceptions of inequality could be a source of social capital as well as demoralisation. Different network structures-dense and weak, homogeneous and heterogeneous- were involved in the creation of social capital and had implications for well being. Coping, enjoyment of life and hope are identified as benefits. Although participation in organisations was confirmed as beneficial, it is suggested that today's heterogeneous neighbourhoods also require regenerated local work opportunities to develop bridging ties necessary for the genesis of inclusive social capital and better health. Despite the capacity of social capital to buffer its harsher effects, the concept is not wholly adequate for explaining the deleterious effects of poverty on health and well being. PMID:11314847

  15. Temporal aggregation impacts on epidemiological simulations employing microcontact data

    PubMed Central

    2012-01-01

    Background Microcontact datasets gathered automatically by electronic devices have the potential augment the study of the spread of contagious disease by providing detailed representations of the study population’s contact dynamics. However, the impact of data collection experimental design on the subsequent simulation studies has not been adequately addressed. In particular, the impact of study duration and contact dynamics data aggregation on the ultimate outcome of epidemiological models has not been studied in detail, leaving the potential for erroneous conclusions to be made based on simulation outcomes. Methods We employ a previously published data set covering 36 participants for 92 days and a previously published agent-based H1N1 infection model to analyze the impact of contact dynamics representation on the simulated outcome of H1N1 transmission. We compared simulated attack rates resulting from the empirically recorded contact dynamics (ground truth), aggregated, typical day, and artificially generated synthetic networks. Results No aggregation or sampling policy tested was able to reliably reproduce results from the ground-truth full dynamic network. For the population under study, typical day experimental designs – which extrapolate from data collected over a brief period – exhibited too high a variance to produce consistent results. Aggregated data representations systematically overestimated disease burden, and synthetic networks only reproduced the ground truth case when fitting errors systemically underestimated the total contact, compensating for the systemic overestimation from aggregation. Conclusions The interdepedendencies of contact dynamics and disease transmission require that detailed contact dynamics data be employed to secure high fidelity in simulation outcomes of disease burden in at least some populations. This finding serves as motivation for larger, longer and more socially diverse contact dynamics tracing experiments and as a

  16. [pi]-Stacking and aggregation of pyridinium-substituted indolizines

    SciTech Connect

    Carter, P.W.; DiMagno, S.G. ); Porter, J.D.; Streitwieser, A. )

    1993-02-04

    The tendency for pyridinium-substituted indolizines to aggregate in aqueous and acetonitrile solution is dominated by solute-solvent interactions and by the amphiphilic nature of the cations. In solution, these compounds exhibit an unusual sequence of discrete, red-shifted fluorescence bands whose intensities are a function of concentration over the range 10[sup [minus]5]--10[sup [minus]3] M. It is proposed that [pi]-stacking of the indolizine residues results in weak electronic interactions ([beta] [approximately]0.13 eV) which are sufficient to result in the delocalization of bound excitonic states over the aggregate. Fluorescence from the aggregate occurs by radiative annihilation of the delocalized exciton. Stepwise dimerization (K[sub 2]) and trimerization (K[sub 3]) equilibrium constants for the cations calculated from the emission spectra range from about 400 to 65,000. Solution conductivity measurements indicate that cation aggregation does not require ion pairing. However, where significant ion-pairing does occur, K[sub 2] and K[sub 3] are increased by at least an order of magnitude. X-ray crystallography was used to determine the structures of cation dimers which form in the solid state, and these structures were used as working models for the geometry of the solution aggregates. Electrostatic and dispersion interactions calculated on the basis of those geometries account for some of the free energy of aggregate formation, but solvent entropic effects are believed to provide the strongest driving force for indolizine aggregation in solution. 58 refs., 8 figs., 4 tabs.

  17. 32 CFR 169a.12 - New requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... analysis shall be conducted to determine whether it is likely that the work can be performed in-house at a... of new requirements involving a capital investment of $500,000 or more will not be redelegated below the level of DAS or equivalent. (e) Approval to budget for a major capital investment associated...

  18. Where's the capital? A geographical essay.

    PubMed

    Jones, Gareth A

    2014-12-01

    This paper is inspired by Thomas Piketty's book Capital in the Twenty-First Century. Piketty does a wonderful job of tracing income and wealth over time, and relating changes to trends of economic and population growth, and drawing out the implications for inequality, inheritance and even democracy. But, he says relatively little about where capital is located, how capital accumulation in one place relies on activities elsewhere, how capital is urbanized with advanced capitalism and what life is like in spaces without capital. This paper asks 'where is the geography in Capital' or 'where is the geography of capital in Capital'? Following Piketty's lead, the paper develops its analysis through a number of important novels. It examines, first, the debate that Jane Austen ignored colonialism and slavery in her treatment of nineteenth century Britain, second, how Balzac and then Zola provide insight to the urban political economy of capital later in the century, and third, how Katherine Boo attends to inequality as the everyday suffering of the poor. PMID:25516349

  19. Aggregated Authentication (AMAC) Using Universal Hash Functions

    NASA Astrophysics Data System (ADS)

    Znaidi, Wassim; Minier, Marine; Lauradoux, Cédric

    Aggregation is a very important issue to reduce the energy consumption in Wireless Sensors Networks (WSNs). There is currently a lack of cryptographic primitives for authentication of aggregated data. The theoretical background for Aggregated Message Authentication Codes (AMACs) has been proposed by Chan and Castelluccia at ISIT 08.

  20. Mineral resource of the month: aggregates

    USGS Publications Warehouse

    Willett, Jason C.

    2012-01-01

    Crushed stone and construction sand and gravel, the two major types of natural aggregates, are among the most abundant and accessible natural resources on the planet. The earliest civilizations used aggregates for various purposes, mainly construction. Today aggregates provide the basic raw materials for the foundation of modern society.

  1. 28 CFR 2.5 - Sentence aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Sentence aggregation. 2.5 Section 2.5 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS... aggregation. When multiple sentences are aggregated by the Bureau of Prisons pursuant to 18 U.S.C. 4161...

  2. 12 CFR 932.8 - Minimum liquidity requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Minimum liquidity requirements. 932.8 Section 932.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.8 Minimum liquidity requirements....

  3. 12 CFR 932.8 - Minimum liquidity requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Minimum liquidity requirements. 932.8 Section 932.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.8 Minimum liquidity requirements....

  4. 12 CFR 932.8 - Minimum liquidity requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Minimum liquidity requirements. 932.8 Section 932.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.8 Minimum liquidity requirements....

  5. 12 CFR 932.8 - Minimum liquidity requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Minimum liquidity requirements. 932.8 Section 932.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.8 Minimum liquidity requirements....

  6. 12 CFR 932.8 - Minimum liquidity requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Minimum liquidity requirements. 932.8 Section 932.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.8 Minimum liquidity requirements....

  7. 49 CFR 639.11 - Lease qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Lease qualification requirements. 639.11 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CAPITAL LEASES Requirements § 639.11 Lease qualification requirements. (a) A lease may qualify for capital assistance if it meets the following criteria: (1)...

  8. Cytotoxic effects of aggregated nanomaterials.

    PubMed

    Soto, Karla; Garza, K M; Murr, L E

    2007-05-01

    This study deals with cytotoxicity assays performed on an array of commercially manufactured inorganic nanoparticulate materials, including Ag, TiO(2), Fe(2)O(3), Al(2)O(3), ZrO(2), Si(3)N(4), naturally occurring mineral chrysotile asbestos and carbonaceous nanoparticulate materials such as multiwall carbon nanotube aggregates and black carbon aggregates. The nanomaterials were characterized by TEM, as the primary particles, aggregates or long fiber dimensions ranged from 2nm to 20microm. Cytotoxicological assays of these nanomaterials were performed utilizing a murine alveolar macrophage cell line and human macrophage and epithelial lung cell lines as comparators. The nanoparticulate materials exhibited varying degrees of cytoxicity for all cell lines and the general trends were similar for both the murine and human macrophage cell lines. These findings suggest that representative cytotoxic responses for humans might be obtained by nanoparticulate exposures to simple murine macrophage cell line assays. Moreover, these results illustrate the utility in performing rapid in vitro assays for cytotoxicity assessments of nanoparticulate materials as a general inquiry of potential respiratory health risks in humans. PMID:17275430

  9. Aggregation of Heterogeneously Charged Colloids.

    PubMed

    Dempster, Joshua M; Olvera de la Cruz, Monica

    2016-06-28

    Patchy colloids are attractive as programmable building blocks for metamaterials. Inverse patchy colloids, in which a charged surface is decorated with patches of the opposite charge, are additionally noteworthy as models for heterogeneously charged biological materials such as proteins. We study the phases and aggregation behavior of a single charged patch in an oppositely charged colloid with a single-site model. This single-patch inverse patchy colloid model shows a large number of phases when varying patch size. For large patch sizes we find ferroelectric crystals, while small patch sizes produce cross-linked gels. Intermediate values produce monodisperse clusters and unusual worm structures that preserve finite ratios of area to volume. The polarization observed at large patch sizes is robust under extreme disorder in patch size and shape. We examine phase-temperature dependence and coexistence curves and find that large patch sizes produce polarized liquids, in contrast to mean-field predictions. Finally, we introduce small numbers of unpatched charged colloids. These can either suppress or encourage aggregation depending on their concentration and the size of the patches on the patched colloids. These effects can be exploited to control aggregation and to measure effective patch size. PMID:27253725

  10. Principles for problem aggregation and assignment in medium scale multiprocessors

    NASA Technical Reports Server (NTRS)

    Nicol, David M.; Saltz, Joel H.

    1987-01-01

    One of the most important issues in parallel processing is the mapping of workload to processors. This paper considers a large class of problems having a high degree of potential fine grained parallelism, and execution requirements that are either not predictable, or are too costly to predict. The main issues in mapping such a problem onto medium scale multiprocessors are those of aggregation and assignment. We study a method of parameterized aggregation that makes few assumptions about the workload. The mapping of aggregate units of work onto processors is uniform, and exploits locality of workload intensity to balance the unknown workload. In general, a finer aggregate granularity leads to a better balance at the price of increased communication/synchronization costs; the aggregation parameters can be adjusted to find a reasonable granularity. The effectiveness of this scheme is demonstrated on three model problems: an adaptive one-dimensional fluid dynamics problem with message passing, a sparse triangular linear system solver on both a shared memory and a message-passing machine, and a two-dimensional time-driven battlefield simulation employing message passing. Using the model problems, the tradeoffs are studied between balanced workload and the communication/synchronization costs. Finally, an analytical model is used to explain why the method balances workload and minimizes the variance in system behavior.

  11. Supramolecular aggregates in vacuum: positively monocharged sodium alkanesulfonate clusters.

    PubMed

    Bongiorno, David; Ceraulo, Leopoldo; Giorgi, Gianluca; Indelicato, Serena; Ruggirello, Angela; Turco Liveri, Vincenzo

    2010-01-01

    The formation and structural features of positively monocharged aggregates of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) and sodium methane--(MetS), butane--(ButS) and octane--(OctS) sulfonate molecules in gas phase have been investigated by electrospray ionization mass spectrometry, energy resolved mass spectrometry and density functional theory (DFT) calculations. The experimental results show that the center-of-mass collision energy required to dissociate 50% of these monocharged aggregates scantly depends on the length of the alkyl chain as well as on the aggregation number. This, together with the large predominance of monocharged species in the mass spectra, was rationalized in terms of an aggregation pattern mainly driven by the counter ions and head groups electrostatic interactions while minor effects were attributed to the steric hindrance caused by the size of the surfactant head group and alkyl chain. DFT calculations show that the most favoured structural arrangement of these aggregates is always characterized by an internal polar core constituted by the sodium counter ions and surfactant head groups surrounded by an external layer composed by the surfactant alkyl chains. PMID:20065519

  12. Sociocultural dimensions of supply and demand for natural aggregate; examples from the Mid-Atlantic region, United States

    USGS Publications Warehouse

    Robinson, Gilpin R., Jr.; Brown, William M.

    2002-01-01

    The United States uses large quantities of natural aggregate to build and maintain a continuously expanding infrastructure. In recent years, per capita demand for aggregate in the United States has grown to about 9.7 metric tons (10.7 tons) per person per year. Over the next 25 years, the aggregate industry expects to mine quantities equivalent to all aggregate mined in the United States over the past 100 years. The issues surrounding supply and demand for aggregate in the mid-Atlantic states of Maryland, Pennsylvania, Virginia, and West Virginia illustrate competing requirements for industrial minerals and many simultaneous social and environmental objectives.

  13. Aggregation and Aggregate Carbon in a Forested Southeastern Coastal Plain Spodosol

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soil aggregation is influenced by the soil environment and is a factor in soil carbon sequestration. Sandy Coastal Plain soils often do not have the clay to promote aggregation nor have been considered soils with high levels of aggregation. This study was conducted to examine the aggregate morpholog...

  14. Aggregation of carbon dioxide sequestration storage assessment units

    USGS Publications Warehouse

    Blondes, Madalyn S.; Schuenemeyer, John H.; Olea, Ricardo A.; Drew, Lawrence J.

    2013-01-01

    The U.S. Geological Survey is currently conducting a national assessment of carbon dioxide (CO2) storage resources, mandated by the Energy Independence and Security Act of 2007. Pre-emission capture and storage of CO2 in subsurface saline formations is one potential method to reduce greenhouse gas emissions and the negative impact of global climate change. Like many large-scale resource assessments, the area under investigation is split into smaller, more manageable storage assessment units (SAUs), which must be aggregated with correctly propagated uncertainty to the basin, regional, and national scales. The aggregation methodology requires two types of data: marginal probability distributions of storage resource for each SAU, and a correlation matrix obtained by expert elicitation describing interdependencies between pairs of SAUs. Dependencies arise because geologic analogs, assessment methods, and assessors often overlap. The correlation matrix is used to induce rank correlation, using a Cholesky decomposition, among the empirical marginal distributions representing individually assessed SAUs. This manuscript presents a probabilistic aggregation method tailored to the correlations and dependencies inherent to a CO2 storage assessment. Aggregation results must be presented at the basin, regional, and national scales. A single stage approach, in which one large correlation matrix is defined and subsets are used for different scales, is compared to a multiple stage approach, in which new correlation matrices are created to aggregate intermediate results. Although the single-stage approach requires determination of significantly more correlation coefficients, it captures geologic dependencies among similar units in different basins and it is less sensitive to fluctuations in low correlation coefficients than the multiple stage approach. Thus, subsets of one single-stage correlation matrix are used to aggregate to basin, regional, and national scales.

  15. 7 CFR 4290.210 - Minimum capital requirements for RBICs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY... his or her sole discretion and based on a showing of special circumstances and good cause may...

  16. 7 CFR 4290.210 - Minimum capital requirements for RBICs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY...) Exception. (1) The Secretary in his or her sole discretion and based on a showing of special...

  17. 7 CFR 4290.210 - Minimum capital requirements for RBICs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY... his or her sole discretion and based on a showing of special circumstances and good cause may...

  18. 42 CFR 489.28 - Special capitalization requirements for HHAs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... dividing the sum of total reported costs of the HHAs in their first year of operation by the sum of the HHAs' total reported visits. The resulting average cost per visit is then multiplied by the projected... change of ownership, if the change of ownership results in a new provider number being issued, must...

  19. 12 CFR 211.12 - Lending limits and capital requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... banks, as described in 12 CFR 250.165. (b) Loans and extensions of credit to one person—(1) Loans and... INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S. Banking Organizations §...

  20. 12 CFR 211.12 - Lending limits and capital requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... banks, as described in 12 CFR 250.165. (b) Loans and extensions of credit to one person—(1) Loans and... Development Bank, or the European Bank for Reconstruction and Development; (B) Any organization, if at...