Science.gov

Sample records for aggregate college operating

  1. Ensuring Machine and Tractor Aggregates Operability

    NASA Astrophysics Data System (ADS)

    Redreev, G. V.

    2016-08-01

    the operability of the machine and tractor aggregates is ensured by processes which occur in machine units and considered as technical systems. In order to develop theoretical understanding of the processes in technical systems as the basis and purpose of the repairserving actions, the author's concept is presented which relies on on the basic concepts of "processes in technical systems", "maintenance and repair of performers", "maintenance and repair of technology" "objectives of the maintenance and repair". Analysis of the basic concepts of "processes in technical systems" made possible to distinguishing four types of relations: of order, stipulation, exactingness, and non-contradiction. It is shown that the implementation of maintenance and repair of technology should be conducted according to the assessment of the effectiveness of processes in technical systems, revealed in complex diagnosis. The perfection of the design of the machine in terms of its technical operation can be estimated according to the degree of consistency of processes in technical systems, purposes of maintenance and repair. In order to increase the efficiency of the lubrication system,the modernised design of the centrifugal oil filter with permanent control of its cleaning power is offered, which allows changing the technology of the maintenance of engine lubrication system by separating the operations of crankcase oil replacement and the rotor filter cleaning.

  2. Using new aggregation operators in rule-based intelligent control

    NASA Technical Reports Server (NTRS)

    Berenji, Hamid R.; Chen, Yung-Yaw; Yager, Ronald R.

    1990-01-01

    A new aggregation operator is applied in the design of an approximate reasoning-based controller. The ordered weighted averaging (OWA) operator has the property of lying between the And function and the Or function used in previous fuzzy set reasoning systems. It is shown here that, by applying OWA operators, more generalized types of control rules, which may include linguistic quantifiers such as Many and Most, can be developed. The new aggregation operators, as tested in a cart-pole balancing control problem, illustrate improved performance when compared with existing fuzzy control aggregation schemes.

  3. Some series of intuitionistic fuzzy interactive averaging aggregation operators.

    PubMed

    Garg, Harish

    2016-01-01

    In this paper, some series of new intuitionistic fuzzy averaging aggregation operators has been presented under the intuitionistic fuzzy sets environment. For this, some shortcoming of the existing operators are firstly highlighted and then new operational law, by considering the hesitation degree between the membership functions, has been proposed to overcome these. Based on these new operation laws, some new averaging aggregation operators namely, intuitionistic fuzzy Hamacher interactive weighted averaging, ordered weighted averaging and hybrid weighted averaging operators, labeled as IFHIWA, IFHIOWA and IFHIHWA respectively has been proposed. Furthermore, some desirable properties such as idempotency, boundedness, homogeneity etc. are studied. Finally, a multi-criteria decision making method has been presented based on proposed operators for selecting the best alternative. A comparative concelebration between the proposed operators and the existing operators are investigated in detail. PMID:27441128

  4. Microcomputer applications for concurrent aggregate mine operation and reclamation planning

    SciTech Connect

    Culp, B.K.

    1990-02-01

    As ever increasing need exists for the planning of aggregate mine operations and reclamation. The purpose of this thesis is to investigate microcomputer applications to assist in the development of a concurrent aggregate mine operation and reclamation plan. The thesis is divided into sections that encompassed three aspects. The first, Section 1 -- concurrent Aggregate Mine Operation and Reclamation Planning, examines the possibility of organizing the operation and reclamation of aggregate mining into a single plan or set of plans. The second section of the thesis, Section 2 -- Microcomputer Applications, describes the use of microcomputers within the mining industry and the landscape architecture profession. This section contains a review of the current types of programs and how they are used. The programs that were used for the case study and their applications and characteristics are also explored. The third and final section of the thesis, Section 3 -- Alden Quarry Case Study, applies the concepts of the first two sections to a practical situation. 35 refs., 49 figs., 7 tabs.

  5. 36th Annual Maintenance & Operations Cost Study: Colleges

    ERIC Educational Resources Information Center

    Agron, Joe

    2007-01-01

    Colleges are focusing increased effort--and money--to improve the physical condition of existing facilities and address a huge backlog of deferred maintenance. According to "American School & University's" 36th annual Maintenance and Operations (M&O) Cost Study, the median college spends 16.4% of total college budget on M&O, up from 11% the year…

  6. 38th Annual Maintenance & Operations Cost Study for Colleges

    ERIC Educational Resources Information Center

    Agron, Joe

    2009-01-01

    The nation's colleges are feeling the pinch of the economic downturn, and maintenance and operations (M&O) budgets especially are under pressure. This article presents data from the 38th annual Maintenance & Operations Cost Study for colleges that can help one in benchmarking expenditures at one's institution. Data provided only targets two-year…

  7. A new multi-period linguistic aggregation operator and its application to financial product selection

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoli; Yang, Wei

    2013-03-01

    In this paper, we propose a new aggregation operator, dynamic 2-tuple linguistic weighted averaging (DTWA) operator, to aggregate linguistic information given in multiple periods. The properties of the new operator are studied and a new multiple attribute decision making method based on the new operator is proposed. Finally, financial product selection problem is provided to illustrate the the proposed method in financial decision making problem.

  8. 26 CFR 1.614-2 - Election to aggregate separate operating mineral interests under section 614(b) prior to its...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Election to aggregate separate operating mineral...) INCOME TAXES (CONTINUED) Natural Resources § 1.614-2 Election to aggregate separate operating mineral...(a) of the Revenue Act of 1964, to aggregate separate operating mineral interests, and,...

  9. Hesitant fuzzy linguistic multicriteria decision-making method based on generalized prioritized aggregation operator.

    PubMed

    Wu, Jia-ting; Wang, Jian-qiang; Wang, Jing; Zhang, Hong-yu; Chen, Xiao-hong

    2014-01-01

    Based on linguistic term sets and hesitant fuzzy sets, the concept of hesitant fuzzy linguistic sets was introduced. The focus of this paper is the multicriteria decision-making (MCDM) problems in which the criteria are in different priority levels and the criteria values take the form of hesitant fuzzy linguistic numbers (HFLNs). A new approach to solving these problems is proposed, which is based on the generalized prioritized aggregation operator of HFLNs. Firstly, the new operations and comparison method for HFLNs are provided and some linguistic scale functions are applied. Subsequently, two prioritized aggregation operators and a generalized prioritized aggregation operator of HFLNs are developed and applied to MCDM problems. Finally, an illustrative example is given to illustrate the effectiveness and feasibility of the proposed method, which are then compared to the existing approach.

  10. FINANCIAL ANALYSIS OF CURRENT OPERATIONS OF COLLEGES AND UNIVERSITIES.

    ERIC Educational Resources Information Center

    SWANSON, JOHN E.; AND OTHERS

    TECHNIQUES FOR DEVELOPING FINANCIAL AND RELATED COST-EFFECTIVENESS DATA FOR PUBLIC AND PRIVATELY SUPPORTED AMERICAN COLLEGES AND UNIVERSITIES WERE STUDIED TO FORMULATE PRINCIPLES, PROCEDURES, AND STANDARDS FOR THE ACCUMULATION AND ANALYSES OF CURRENT OPERATING COSTS. AFTER SEPARATE ANALYSES OF INSTITUTIONAL PROCEDURES AND REPORTS, ANALYTIC UNITS…

  11. Evaluating student's academic achievement by a non-additive aggregation operator

    NASA Astrophysics Data System (ADS)

    Abdullah, Siti Rohana Goh; Kasim, Maznah Mat; Ramli, Mohammad Fadzli; Sakib, Elyana

    2014-07-01

    In the context of multi-criteria decision making (MCDM), the average method used in Integrated Students Information System (ISIS) can be classified as an additive measure where the students' academic achievement are aggregated based on the assumption that there is no interaction among the evaluation criteria or the criteria are independent. This method is not suitable to be used if the schools look for equilibrium in their students' achievement. Thus, the non-additive aggregation operator is chosen to analyze students' academic achievements by further taking into accounts the interactions between the subjects. The measures of interaction were represented as λ-fuzzy measures. The effectiveness and success of this non-additive measures can be recognized by comparing the results of the new ranking which was obtained by nonadditive aggregation operator with the current approach of ranking that were based on the global scores using average score method. Throughout this study, it could be postulated that employing the non-additive aggregation operators to obtain an overall evaluation is more suitable because this method able to deal with interactions among subjects whereas the average method only assumes that there is no interaction between subjects or the subjects must be independent.

  12. Community College Finance: A Cost Analysis of Community College Expenditures Related to Maintenance and Operations

    ERIC Educational Resources Information Center

    Collins, Michael T.

    2011-01-01

    The purpose of this study is to develop a costing model for maintenance and operations expenditures among 16 single-campus California community college districts and assess the impact of a variety of variables including size of student enrollment, physical plant age, acreage, gross square footage, and general obligation facility bonds on district…

  13. 27 CFR 19.34 - Experimental or research operations by scientific institutions and colleges of learning.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... operations by scientific institutions and colleges of learning. 19.34 Section 19.34 Alcohol, Tobacco Products... Experimental Operations § 19.34 Experimental or research operations by scientific institutions and colleges of learning. (a) General. The appropriate TTB officer may authorize any scientific university, college...

  14. The Capitol College Space Operations Institute: A Partnership with NASA

    NASA Astrophysics Data System (ADS)

    Gibbs, M. G.

    2010-12-01

    This presentation describes the Capitol College Space Operations Institute (SOI) partnership with NASA Goddard Space Flight Center and the real-world learning experiences provided to college students. The education and public outreach (EPO) partnership works to directly encourage and support students to enter careers in the science, technology, engineering and math (STEM) disciplines and advance the cause of improving science literacy. The Capitol College SOI serves as a back-up control center for two NASA missions. The first is the Tropical Rainforest Measurement Mission (TRMM), which is a research satellite designed to help our understanding of the water cycle in the current climate system. By covering the tropical and semi-tropical regions of the Earth, TRMM provides much needed data on rainfall and the heat release associated with rainfall. The second is the Wide-field Infrared Survey Explorer (WISE) mission that is providing a vast storehouse of knowledge about the solar system, the Milky Way, and the Universe. The session provides both an update regarding the SOI and provides new information regarding the SOI work with the two NASA missions. Emerging best practices from the learning experiences the SOI provides college students in serving as a real-life back-up control center will also be shared.

  15. Outcomes of a Christian College Education: A Comparison of CCCU Students' Gains to the National Aggregate

    ERIC Educational Resources Information Center

    Schreiner, Laurie A.; Kim, Young K.

    2011-01-01

    This study examined the patterns of college experiences and outcomes among 3,501 students attending colleges or universities that belong to the Council for Christian Colleges & Universities (CCCU). As part of the CCCU-sponsored Comprehensive Assessment Project (CAP), 25 member institutions collected data from their first-year students using the…

  16. Historically Black Colleges and Universities: Improving Operations through an Enterprise Resource Planning System

    ERIC Educational Resources Information Center

    Hardee, Teresa

    2012-01-01

    There are a variety of challenges facing colleges and universities today. With shrinking public funding, many colleges and universities must rethink their operations to ensure that they are operating efficiently. Historically Black Colleges and Universities (HBCUs) have an even more daunting task in a downturned economy because they are often…

  17. 27 CFR 19.34 - Experimental or research operations by scientific institutions and colleges of learning.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... operations by scientific institutions and colleges of learning. 19.34 Section 19.34 Alcohol, Tobacco Products... SPIRITS PLANTS Administrative and Miscellaneous Provisions Alternate Methods Or Procedures and Experimental Operations § 19.34 Experimental or research operations by scientific institutions and colleges...

  18. Water level measurements for modeling hydraulic properties in the 300-FF-5 and 100 Aggregate Area Operable units

    SciTech Connect

    Campbell, M.D.; McMahon, W.J.; Simpson, K.R.

    1993-04-01

    Pressure transducers connected to dataloggers were used to measure ground water and Columbia River water elevations simultaneously and hourly at 35 locations in the 300-FF-5 Operable Unit and 16 locations in the 100 Aggregate Area Operable Unit on the Hanford Site. Water temperatures were also measured at 12 of these locations. This report details the findings of these studies.

  19. 26 CFR 1.614-2 - Election to aggregate separate operating mineral interests under section 614(b) prior to its...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) INCOME TAXES (CONTINUED) Natural Resources § 1.614-2 Election to aggregate separate operating mineral... mine, well, or other natural deposit were in the production stage. The term does not include royalty... various natural resources industries or in any one of the natural resources industries, such as coal,...

  20. Cerritos Community College: Improvements Needed in Aspects of Operating the District and Its Auxiliary Organization.

    ERIC Educational Resources Information Center

    California State Office of the Auditor General, Sacramento.

    This audit report discusses the operation of the Enterprise Fund by Cerritos Community College District in California. In addition, the Cerritos College Foundation's conflict of interest policies, its relationship with the district, and its award of contracts for services was reviewed. It was found that the district needed improvement in its…

  1. 27 CFR 19.34 - Experimental or research operations by scientific institutions and colleges of learning.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... operations by scientific institutions and colleges of learning. 19.34 Section 19.34 Alcohol, Tobacco Products... learning. (a) General. The appropriate TTB officer may authorize any scientific university, college of learning, or institution of scientific research to produce, receive, blend, treat, test, and store...

  2. An Empirical Model for Formulating Operational Missions for Community Colleges.

    ERIC Educational Resources Information Center

    Richardson, Richard C., Jr.; Doucette, Donald S.

    A research project was conducted to develop and implement a model for community college missions. The new model would depart from existing models, which utilize a hierarchy of decreasing levels of generality beginning with institutional missions and culminating in objectives. In contrast, this research defined institutional mission in terms of…

  3. Colleges Get Greener in Operations, but Teaching Sustainability Declines

    ERIC Educational Resources Information Center

    Carlson, Scott

    2008-01-01

    More colleges are making sustainability programs a high priority, putting more resources into energy-conservation efforts, and setting goals to reduce carbon emissions, according to survey results released by the National Wildlife Federation. Given the popularity of all things green, that is not surprising. The surprising part of the federation's…

  4. Aims College Operation Bridge Project. Phase 1, Preliminary Evaluation Report.

    ERIC Educational Resources Information Center

    National Spanish Speaking Management Association, Washington, DC.

    Recognizing the adverse effects of poverty on Mexican Americans, and determined to help narrow the barriers caused by a low socioeconomic status, Aims college, a locally funded institution in Weld County, Colorado, conceptualized and implemented a special needs program designed to provide vocational and occupational training for disadvantaged…

  5. Continuity of operations planning in college athletic programs: The case for incorporating Federal Emergency Management Guidelines.

    PubMed

    Hall, Stacey A; Allen, Brandon L; Phillips, Dennis

    2016-01-01

    College athletic departments have a responsibility to provide a safe environment for student-athletes; however, most colleges do not have a crisis management plan that includes procedures for displaced student-athletes or alternate facilities to perform athletic events. Continuity of operations planning ensures athletic programs are equipped to maintain essential functions during, or shortly after, a disruption of operations due to possible hazards. Previous studies have identified a lack of emergency preparedness and continuity planning in college athletic departments. The purpose of this article is to illustrate in detail one approach to disaster planning for college athletic departments, namely the Federal Emergency Management Agency (FEMA) continuity of operations framework. By adhering to FEMA guidelines and promoting a best practices model, athletic programs can effectively plan to address potential hazards, as well as protect the organization's brand, image, and financial sustainability after a crisis event.

  6. Continuity of operations planning in college athletic programs: The case for incorporating Federal Emergency Management Guidelines.

    PubMed

    Hall, Stacey A; Allen, Brandon L; Phillips, Dennis

    2016-01-01

    College athletic departments have a responsibility to provide a safe environment for student-athletes; however, most colleges do not have a crisis management plan that includes procedures for displaced student-athletes or alternate facilities to perform athletic events. Continuity of operations planning ensures athletic programs are equipped to maintain essential functions during, or shortly after, a disruption of operations due to possible hazards. Previous studies have identified a lack of emergency preparedness and continuity planning in college athletic departments. The purpose of this article is to illustrate in detail one approach to disaster planning for college athletic departments, namely the Federal Emergency Management Agency (FEMA) continuity of operations framework. By adhering to FEMA guidelines and promoting a best practices model, athletic programs can effectively plan to address potential hazards, as well as protect the organization's brand, image, and financial sustainability after a crisis event. PMID:26963231

  7. Toward a Conceptualization of Learning Processes in the College Classroom I: A Review of Operant Research.

    ERIC Educational Resources Information Center

    Martin, Robert F.

    The theory of and research on the application of operant procedures to the college classroom is reviewed. Practical limitations of these procedures and shortcomings of this research are discussed. Covered in this paper are: (1) theoretical foundations; (2) operant foundations in education; (3) research on programed instruction; (4) the…

  8. Helicopter Parents of Community College Students: How Community College Professionals Operationally Define and Address This Phenomenon

    ERIC Educational Resources Information Center

    Hightower, Helen C.

    2014-01-01

    This study examined whether the phenomenon of "parental over-involvement" occurred in the Virginia Community College System. Concern has been expressed in the popular and academic literature in recent years over the increased level of parental involvement at four year institutions whose student bodies consist almost exclusively of…

  9. NASA/Capitol College Space Operations Institute Project: A Problem Based Learning Approach

    NASA Astrophysics Data System (ADS)

    Walters, A.; Wagner, D. M.; Gibbs, M. G.; Marius, J. L.

    2010-08-01

    This paper describes the experiences and lessons learned during the formation of the NASA/Capitol College Space Operations Institute (SOI) partnership. The partnership works to advance the cause of not only improving science literacy, but directly encouraging and supporting students to enter careers in the STEM disciplines. Specifically, the SOI program conducts the following: Design, build, and implement an Upgraded Ground System for the TOMS satellite. Transfer prime TOMS operations to the control center at Capitol College. Educate undergraduate students with the "right stuff" for future STEM employment. Support the Astronautical Engineering degree program. Implement the TRMM BMOC project. More than 67 students from various majors at Capitol College participated in several NASA missions where they gained hands on experiences preparing them with the skills needed by the Aerospace industry. Examples of NASA missions students were or currently involved with are: UGS, ERBS, UARS, TOMS and TRMM satellite operations and TOMS and TRMM ground system development.

  10. An Investigation of Strategies of Operation under Conditions of Reduced Funding in Selected Community Colleges.

    ERIC Educational Resources Information Center

    Smith, Norman D.

    This four-part report examines the management of retrenchment at six representative Southern California community colleges and two community college districts: Victor Valley College, Mount San Jacinto College, Citrus College, Chaffey College, Mount San Antonio College, Riverside City College, the San Bernardino Community College District, and the…

  11. A comparative analysis of lightweight aggregate and cement kilns operated under the Boiler and Industrial Furnace Rule

    SciTech Connect

    Franklin, G.P.; Jewett, J.J. III

    1994-12-31

    Eighteen lightweight aggregate (LWA) kilns at five locations currently have interim status under the BIF Rule. Two additional LWA kilns at a sixth location are burning hazardous waste fuel under an incinerator permit. Although these units comprise a significant fraction of the existing and potential commercial BIF capacity in the Eastern United States, relatively little technical literature has been generated regarding the burning of hazardous waste in LWA kilns, and both regulators and the public tend to view LWA kilns as a variant of cement kilns. However, along with similarities, there are a number of important differences between these two categories of industrial furnaces. Among the more significant are differences in typical kiln size, raw feed, operating conditions and uses of kiln dust. This paper is a comparative analysis of cement and lightweight aggregate kilns operating under BIF. It addresses design features, raw material and fuel emissions, products and residuals. Both technical and legal/regulatory of differences are analyzed. Finally, the potential impact of EPA`s Waste Combustion Strategy upon LWA kilns is evaluated.

  12. 27 CFR 19.34 - Experimental or research operations by scientific institutions and colleges of learning.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Experimental or research operations by scientific institutions and colleges of learning. 19.34 Section 19.34 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL DISTILLED SPIRITS PLANTS Administrative...

  13. Fiscal Year 1979 Operating Budget Recommendations for the Illinois Public Community College System.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    The history of Illinois community college operating finance policy is traced from July 1964 with the establishment of a semester hour flat rate grant (FRG) through the following: an equalization formula in addition to the FRG; supplemental non-business occupational grants; supplemental appropriations during a sudden enrollment increase;…

  14. 77 FR 26321 - Reed College, Reed Research Nuclear Reactor, Renewed Facility Operating License No. R-112

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... COMMISSION Reed College, Reed Research Nuclear Reactor, Renewed Facility Operating License No. R-112 AGENCY..., Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, Rockville, MD 20852. Telephone..., Research and Test Reactors Licensing Branch, Division of Policy and Rulemaking, Office of Nuclear...

  15. 27 CFR 19.71 - Experimental or research operations by scientific institutions and colleges of learning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Experimental or research operations by scientific institutions and colleges of learning. (a) General. The... scientific research to produce, receive, blend, treat, test, and store spirits, without payment of tax, for... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Experimental or...

  16. Preliminary List of Functions and Operations of Lorain County Community College.

    ERIC Educational Resources Information Center

    Boylan, Timothy V.; And Others

    This Management Information System tool provides an official definition for and enumerates the operational components of each of the 13 functions of Lorain County Community College. These functions are: (1) provide instruction, (2) provide instructional support, (3) facilitate organized research, (4) develop faculty resources, (5) develop…

  17. Repeated-batch operation for the synthesis of lactulose with β-galactosidase immobilized by aggregation and crosslinking.

    PubMed

    Guerrero, Cecilia; Vera, Carlos; Araya, Erick; Conejeros, Raúl; Illanes, Andrés

    2015-08-01

    Synthesis of lactulose under repeated-batch operation was done with cross-linked aggregates of Aspergillus oryzae β-galactosidase (CLAGs). The effect of the crosslinking agent to enzyme mass ratio and cross-linking time were first evaluated. Best results were obtained at 5.5gdeglutaraldehyde/g enzyme at 5h of cross-linking, obtaining a specific activity of 15,000IUg(-1), with 30% immobilization yield. CLAG was more stable than the free enzyme under non-reactive conditions with a half-life of 123h at 50°C and when operated in repeated-batch mode, yield and productivity was 3.8 and 4.3 times higher. Maximum number of batches was determined considering biocatalyst replacement at 50% residual activity. 98 and 27 batches could be performed under such criterion at fructose/lactose molar ratio of 4 and 20 respectively, reflecting that enzyme stability is strongly affected by the sugars distribution in the reaction medium.

  18. 14 CFR 93.343 - Requirements for aircraft operations to or from College Park Airport, Potomac Airfield, or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... in 49 CFR part 1562, subpart A; (2) Before departing, the pilot files an IFR or DC FRZ or DC SFRA... from College Park Airport, Potomac Airfield, or Washington Executive/Hyde Field Airport. 93.343 Section... Special Flight Rules Area § 93.343 Requirements for aircraft operations to or from College Park...

  19. 14 CFR 93.343 - Requirements for aircraft operations to or from College Park Airport, Potomac Airfield, or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in 49 CFR part 1562, subpart A; (2) Before departing, the pilot files an IFR or DC FRZ or DC SFRA... from College Park Airport, Potomac Airfield, or Washington Executive/Hyde Field Airport. 93.343 Section... Special Flight Rules Area § 93.343 Requirements for aircraft operations to or from College Park...

  20. 14 CFR 93.343 - Requirements for aircraft operations to or from College Park Airport, Potomac Airfield, or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... in 49 CFR part 1562, subpart A; (2) Before departing, the pilot files an IFR or DC FRZ or DC SFRA... from College Park Airport, Potomac Airfield, or Washington Executive/Hyde Field Airport. 93.343 Section... Special Flight Rules Area § 93.343 Requirements for aircraft operations to or from College Park...

  1. 14 CFR 93.343 - Requirements for aircraft operations to or from College Park Airport, Potomac Airfield, or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... in 49 CFR part 1562, subpart A; (2) Before departing, the pilot files an IFR or DC FRZ or DC SFRA... from College Park Airport, Potomac Airfield, or Washington Executive/Hyde Field Airport. 93.343 Section... Special Flight Rules Area § 93.343 Requirements for aircraft operations to or from College Park...

  2. 14 CFR 93.343 - Requirements for aircraft operations to or from College Park Airport, Potomac Airfield, or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... in 49 CFR part 1562, subpart A; (2) Before departing, the pilot files an IFR or DC FRZ or DC SFRA... from College Park Airport, Potomac Airfield, or Washington Executive/Hyde Field Airport. 93.343 Section... Special Flight Rules Area § 93.343 Requirements for aircraft operations to or from College Park...

  3. Developing a next-generation community college curriculum forenergy-efficient high-performance building operations

    SciTech Connect

    Crabtree, Peter; Kyriakopedi, Nick; Mills, Evan; Haves, Philip; Otto, Roland J.; Piette, Mary Ann; Xu, Peng; Diamond, Rick; Frost, Chuck; Deringer, Joe

    2004-05-01

    The challenges of increased technological demands in today's workplace require virtually all workers to develop higher-order cognitive skills including problem solving and systems thinking in order to be productive. Such ''habits of mind'' are viewed as particularly critical for success in the information-based workplace, which values reduced hierarchy, greater worker independence, teamwork, communications skills, non-routine problem solving, and understanding of complex systems. The need is particularly compelling in the buildings arena. To scope the problem, this paper presents the results of interviews and focus groups--conducted by Oakland California's Peralta Community College District and Lawrence Berkeley National Laboratory--in which approximately 50 industry stakeholders discussed contemporary needs for building operator education at the community college level. Numerous gaps were identified between the education today received by building operators and technicians and current workplace needs. The participants concurred that many of the problems seen today in achieving and maintaining energy savings in buildings can be traced to inadequacies in building operation and lack of awareness and knowledge about how existing systems are to be used, monitored, and maintained. Participants and others we interviewed affirmed that while these issues are addressed in various graduate-level and continuing education programs, they are virtually absent at the community college level. Based on that assessment of industry needs, we present a new curriculum and innovative simulation-based learning tool to provide technicians with skills necessary to commission and operate high-performance buildings, with particular emphasis on energy efficiency and indoor environmental quality in the context of HVAC&R equipment and control systems.

  4. Policies, Procedures, and Regulations; Governing the Establishment and Operation of the Comprehensive Community Colleges of Virginia.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Community Colleges, Richmond.

    This manual may be useful to communities planning the establishment of a junior college system. It covers the types of programs to be offered by the colleges; coordination of all programs of higher education by the State Council of Higher Education; eligibility of students; length of term and attendance day; establishment of colleges, including…

  5. Western Co-operative College (Study of an Agency); Project Study for Education 480, University of Saskatchewan, Saskatoon.

    ERIC Educational Resources Information Center

    Chapman, H.E.; And Others

    Based on the philosophy of individuals taking responsibility for their own destinies through mutual self help, and drawing heavily from European cooperatives, Western Co-operative College provides training for elected officials and employees of cooperatives such as marketing, consumer, finance, service, and education cooperatives, and government…

  6. Operating Ratios and Institutional Characteristics Affecting the Responsiveness of Black Colleges and Universities to Professional Allied Health Programs.

    ERIC Educational Resources Information Center

    Holmes, Everlena M.; Andrew, Loyd D.

    Factors that affect the implementation of professional allied health education programs were studied at 64 four-year black colleges and universities that had no such programs before 1975-76. By 1980, six of the institutions had implemented these programs. Twenty-seven operating ratios and seven institutional characteristics were analyzed, based on…

  7. Joint Venture Partnerships: A Scarce Funds Approach to Acquiring and Operating New Facilities at State Colleges and Universities.

    ERIC Educational Resources Information Center

    Elam, Houston G.

    This book explores partnerships between state colleges and universities and local governments to build and operate facilities in light of increasingly scarce funds at the institutions. With new partnerships, institutions risk losing authority over new facilities, but the benefits of joint partnerships far outweigh the risks. Examined are three…

  8. A Study of the Support Operations of Independent Liberal Arts Colleges.

    ERIC Educational Resources Information Center

    Parker, Norman A.

    Smaller residential colleges provide the highest degree of support, i.e., board, room, close student-faculty relationships, large financial aid, extensive cultural programs in music, drama, and athletics for student participation, and those other prerequisites that make the whole life at the small residential college a learning experience. Using…

  9. Identification of Institutional Genderedness through Organizational Operations: An Analysis of Community College Working Environments

    ERIC Educational Resources Information Center

    Jones, Stephanie J.; Warnick, Erika M.; Taylor, Colette M.

    2015-01-01

    Though the number of women employed in the workforce has increased, there continues to be an inequity in employment of women in the highest ranks of community colleges. Guided by gendered organizational theory, the study looked at both overt and covert knowledge of genderedness at community colleges. As one might infer, institutional genderedness…

  10. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1995-01-01

    Part of the 1994 Industrial Minerals Review. The production, consumption, and applications of construction aggregates are reviewed. In 1994, the production of construction aggregates, which includes crushed stone and construction sand and gravel combined, increased 7.7 percent to 2.14 Gt compared with the previous year. These record production levels are mostly a result of funding for highway construction work provided by the Intermodal Surface Transportation Efficiency Act of 1991. Demand is expected to increase for construction aggregates in 1995.

  11. Construction aggregates

    USGS Publications Warehouse

    Langer, W.H.; Tepordei, V.V.; Bolen, W.P.

    2000-01-01

    Construction aggregates consist primarily of crushed stone and construction sand and gravel. Total estimated production of construction aggregates increased in 1999 by about 2% to 2.39 Gt (2.64 billion st) compared with 1998. This record production level continued an expansion that began in 1992. By commodities, crushed stone production increased 3.3%, while sand and gravel production increased by about 0.5%.

  12. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1994-01-01

    Part of a special section on industrial minerals in 1993. The 1993 production of construction aggregates increased 6.3 percent over the 1992 figure, to reach 2.01 Gt. This represents the highest estimated annual production of combined crushed stone and construction sand and gravel ever recorded in the U.S. The outlook for construction aggregates and the issues facing the industry are discussed.

  13. Howard Community College 1986-87 Institutional Indicators for Proposed Operating Budget.

    ERIC Educational Resources Information Center

    Radcliffe, Susan; Novak, Virginia E.

    This report presents a series of graphs and tables, offering information on students, instruction, faculty, and finances at Howard Community College (HCC) in Columbia, Maryland. Part 1 provides profiles and projections of HCC's students, including a 10-year overview of full-time equivalent (FTE) enrollment, 1976-85; enrollment projections,…

  14. Beyond Lip-Service: An Operational Definition of "Learning-Centered College"

    ERIC Educational Resources Information Center

    Bosch, William C.; Hester, Jessica L.; MacEntee, Virginia M.; MacKenzie, James A.; Morey, T. Mark; Nichols, James T.; Pacitti, Patricia A.; Shaffer, Barbara A.; Tomascak, Paul B.; Weber, Suzanne P.; Young, Rosalie R.

    2008-01-01

    Faculty, staff, and student perceptions of high-quality learning experiences were explored using focus groups attempting to define a "learning-centered" college. Common themes emerged suggesting that a successful learning community requires faculty-student collaboration, effective communication, critical thinking skills, reciprocal respect,…

  15. An Example of Regional Co-operation: The Colombo Plan Staff College for Technician Education

    ERIC Educational Resources Information Center

    Chandrakant, L. S.

    1976-01-01

    Described is the Staff College in Singapore, recently established by the 27 member countries of the Colombo Plan to provide training for technicians, conduct technical education conferences, assist Asian countries in technical curriculum development, undertake research into technical problems and act as a clearinghouse for information on…

  16. A Systems Approach to the Design and Operation of Effective Marketing Programs in Community Colleges.

    ERIC Educational Resources Information Center

    Scigliano, John A.

    1983-01-01

    Presents a research-based marketing model consisting of an environmental scanning process, a series of marketing audits, and an information-processing scheme. Views the essential elements of college marketing as information flow; high-level, long-term commitment; diverse strategies; innovation; and a broad view of marketing. Includes a marketing…

  17. The Effect of Florida's Bright Futures Program on College Enrollment and Degree Production: An Aggregated-Level Analysis

    ERIC Educational Resources Information Center

    Zhang, Liang; Hu, Shouping; Sensenig, Victor

    2013-01-01

    In this study, we investigate the impact of the Bright Futures Scholarship Program on college enrollment and degree production in Florida by using IPEDS enrollment, migration, and completion data. Results suggest large and significant enrollment effects at Florida's public 4- and 2-year institutions, for both full-time and part-time…

  18. A Proposal to the President to Establish a Year-Round Operation and an Annual Assignment System for Omega College, Beginning Summer 1974.

    ERIC Educational Resources Information Center

    Reda, Mario R.

    The purpose of this paper is the presentation of a proposal for a year-round operation and an annual assignment system (YRO/AAS) to the administrative officers of the College of DuPage, Glen Ellyn, Illinois. The proposal is comprised of four chapters. The first chapter deals with the significance of the study in terms of the College of DuPage's…

  19. Construction aggregates

    USGS Publications Warehouse

    Nelson, T.I.; Bolen, W.P.

    2007-01-01

    Construction aggregates, primarily stone, sand and gravel, are recovered from widespread naturally occurring mineral deposits and processed for use primarily in the construction industry. They are mined, crushed, sorted by size and sold loose or combined with portland cement or asphaltic cement to make concrete products to build roads, houses, buildings, and other structures. Much smaller quantities are used in agriculture, cement manufacture, chemical and metallurgical processes, glass production and many other products.

  20. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1996-01-01

    Part of the Annual Commodities Review 1995. Production of construction aggregates such as crushed stone and construction sand and gravel showed a marginal increase in 1995. Most of the 1995 increases were due to funding for highway construction work. The major areas of concern to the industry included issues relating to wetlands classification and the classification of crystalline silica as a probable human carcinogen. Despite this, an increase in demand is anticipated for 1996.

  1. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1993-01-01

    Part of a special section on the market performance of industrial minerals in 1992. Production of construction aggregates increased by 4.6 percent in 1992. This increase was due, in part, to the increased funding for transportation and infrastructure projects. The U.S. produced about 1.05 Gt of crushed stone and an estimated 734 Mt of construction sand and gravel in 1992. Demand is expected to increase by about 5 percent in 1993.

  2. Construction aggregates

    USGS Publications Warehouse

    Bolen, W.P.; Tepordei, V.V.

    2001-01-01

    The estimated production during 2000 of construction aggregates, crushed stone, and construction sand and gravel increased by about 2.6% to 2.7 Gt (3 billion st), compared with 1999. The expansion that started in 1992 continued with record production levels for the ninth consecutive year. By commodity, construction sand and gravel production increased by 4.5% to 1.16 Gt (1.28 billion st), while crushed stone production increased by 1.3% to 1.56 Gt (1.72 billion st).

  3. Businessperson-in-Residence: One of a Series of Guides for Planning and Operating a Corporate/College Project.

    ERIC Educational Resources Information Center

    Council on Corporate/College Communications, Washington, DC.

    The Businessperson-in-Residence program at Trenton State College in New Jersey is described. It is a four-part program designed to build better long-term relationships between the college and business community. The overall program was planned by a joint business-college task force to meet mutual objectives. The businessperson, working out of a…

  4. Arkansas Public Higher Education Operating Recommendations: Fiscal Year 2010-11. Volume 2: Colleges

    ERIC Educational Resources Information Center

    Arkansas Department of Higher Education, 2010

    2010-01-01

    This publication provides summaries of appropriations of public higher education institutions in Arkansas for the Fiscal Year 2010-11. It also provides operating recommendations of the Arkansas Public Higher Education Coordinating Board for the Fiscal Year 2010-11 for each institution. [For Volume 1, see ED511332.

  5. Regional Comparative Unit Cost Studies for Maintenance and Operation of Physical Plants in Universities and Colleges in Central States Region and Rocky Mountain Region.

    ERIC Educational Resources Information Center

    Association of Physical Plant Administrators, Corvallis, OR.

    Presented in this document are data pertaining to maintenance and operations costs at colleges and universities in the central states region and the Rocky Mountain region. The major accounts included in the cost analysis are: (1) physical plant administration, (2) building maintenance, (3) custodial services, (4) utilities, (5) landscape and…

  6. Policies, Procedures, Guidelines, Rules and Regulations for the Administration and Operation of Public Junior Colleges. (Compilation of Existing Actions of the Illinois Junior College Board.)

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    This document is a compilation of existing policies, procedures, guidelines, rules, and regulations previously adopted by the Illinois Junior College Board, from its establishment in September 1965 through May 1973. Also in the document is a listing of due dates for various documents that are to be sent to the board office during the following…

  7. Aggregation server for grid-integrated vehicles

    DOEpatents

    Kempton, Willett

    2015-05-26

    Methods, systems, and apparatus for aggregating electric power flow between an electric grid and electric vehicles are disclosed. An apparatus for aggregating power flow may include a memory and a processor coupled to the memory to receive electric vehicle equipment (EVE) attributes from a plurality of EVEs, aggregate EVE attributes, predict total available capacity based on the EVE attributes, and dispatch at least a portion of the total available capacity to the grid. Power flow may be aggregated by receiving EVE operational parameters from each EVE, aggregating the received EVE operational parameters, predicting total available capacity based on the aggregated EVE operational parameters, and dispatching at least a portion of the total available capacity to the grid.

  8. Applications of aggregation theory to sustainability assessment

    SciTech Connect

    Pollesch, N.; Dale, V. H.

    2015-04-01

    In order to aid in transition towards operations that promote sustainability goals, researchers and stakeholders use sustainability assessments. Although assessments take various forms, many utilize diverse sets of indicators that can number anywhere from two to over 2000. Indices, composite indicators, or aggregate values are used to simplify high dimensional and complex data sets and to clarify assessment results. Although the choice of aggregation function is a key component in the development of the assessment, there are few examples to be found in literature to guide appropriate aggregation function selection. This paper develops a connection between the mathematical study of aggregation functions and sustainability assessment in order to aid in providing criteria for aggregation function selection. Relevant mathematical properties of aggregation functions are presented and interpreted. Lastly, we provide cases of these properties and their relation to previous sustainability assessment research. Examples show that mathematical aggregation properties can be used to address the topics of compensatory behavior and weak versus strong sustainability, aggregation of data under varying units of measurements, multiple site multiple indicator aggregation, and the determination of error bounds in aggregate output for normalized and non-normalized indicator measures.

  9. Applications of aggregation theory to sustainability assessment

    DOE PAGES

    Pollesch, N.; Dale, V. H.

    2015-04-01

    In order to aid in transition towards operations that promote sustainability goals, researchers and stakeholders use sustainability assessments. Although assessments take various forms, many utilize diverse sets of indicators that can number anywhere from two to over 2000. Indices, composite indicators, or aggregate values are used to simplify high dimensional and complex data sets and to clarify assessment results. Although the choice of aggregation function is a key component in the development of the assessment, there are few examples to be found in literature to guide appropriate aggregation function selection. This paper develops a connection between the mathematical study ofmore » aggregation functions and sustainability assessment in order to aid in providing criteria for aggregation function selection. Relevant mathematical properties of aggregation functions are presented and interpreted. Lastly, we provide cases of these properties and their relation to previous sustainability assessment research. Examples show that mathematical aggregation properties can be used to address the topics of compensatory behavior and weak versus strong sustainability, aggregation of data under varying units of measurements, multiple site multiple indicator aggregation, and the determination of error bounds in aggregate output for normalized and non-normalized indicator measures.« less

  10. Ash Aggregates in Proximal Settings

    NASA Astrophysics Data System (ADS)

    Porritt, L. A.; Russell, K.

    2012-12-01

    Ash aggregates are thought to have formed within and been deposited by the eruption column and plume and dilute density currents and their associated ash clouds. Moist, turbulent ash clouds are considered critical to ash aggregate formation by facilitating both collision and adhesion of particles. Consequently, they are most commonly found in distal deposits. Proximal deposits containing ash aggregates are less commonly observed but do occur. Here we describe two occurrences of vent proximal ash aggregate-rich deposits; the first within a kimberlite pipe where coated ash pellets and accretionary lapilli are found within the intra-vent sequence; and the second in a glaciovolcanic setting where cored pellets (armoured lapilli) occur within <1 km of the vent. The deposits within the A418 pipe, Diavik Diamond Mine, Canada, are the residual deposits within the conduit and vent of the volcano and are characterised by an abundance of ash aggregates. Coated ash pellets are dominant but are followed in abundance by ash pellets, accretionary lapilli and rare cored pellets. The coated ash pellets typically range from 1 - 5 mm in diameter and have core to rim ratios of approximately 10:1. The formation and preservation of these aggregates elucidates the style and nature of the explosive phase of kimberlite eruption at A418 (and other pipes?). First, these pyroclasts dictate the intensity of the kimberlite eruption; it must be energetic enough to cause intense fragmentation of the kimberlite to produce a substantial volume of very fine ash (<62 μm). Secondly, the ash aggregates indicate the involvement of moisture coupled with the presence of dilute expanded eruption clouds. The structure and distribution of these deposits throughout the kimberlite conduit demand that aggregation and deposition operate entirely within the confines of the vent; this indicates that aggregation is a rapid process. Ash aggregates within glaciovolcanic sequences are also rarely documented. The

  11. Environmentalism and natural aggregate mining

    USGS Publications Warehouse

    Drew, L.J.; Langer, W.H.; Sachs, J.S.

    2002-01-01

    Sustaining a developed economy and expanding a developing one require the use of large volumes of natural aggregate. Almost all human activity (commercial, recreational, or leisure) is transacted in or on facilities constructed from natural aggregate. In our urban and suburban worlds, we are almost totally dependent on supplies of water collected behind dams and transported through aqueducts made from concrete. Natural aggregate is essential to the facilities that produce energy-hydroelectric dams and coal-fired powerplants. Ironically, the utility created for mankind by the use of natural aggregate is rarely compared favorably with the environmental impacts of mining it. Instead, the empty quarries and pits are seen as large negative environmental consequences. At the root of this disassociation is the philosophy of environmentalism, which flavors our perceptions of the excavation, processing, and distribution of natural aggregate. The two end-member ideas in this philosophy are ecocentrism and anthropocentrism. Ecocentrism takes the position that the natural world is a organism whose arteries are the rivers-their flow must not be altered. The soil is another vital organ and must not be covered with concrete and asphalt. The motto of the ecocentrist is "man must live more lightly on the land." The anthropocentrist wants clean water and air and an uncluttered landscape for human use. Mining is allowed and even encouraged, but dust and noise from quarry and pit operations must be minimized. The large volume of truck traffic is viewed as a real menace to human life and should be regulated and isolated. The environmental problems that the producers of natural aggregate (crushed stone and sand and gravel) face today are mostly difficult social and political concerns associated with the large holes dug in the ground and the large volume of heavy truck traffic associated with quarry and pit operations. These concerns have increased in recent years as society's demand for

  12. Thermodynamics of Protein Aggregation

    NASA Astrophysics Data System (ADS)

    Osborne, Kenneth L.; Barz, Bogdan; Bachmann, Michael; Strodel, Birgit

    Amyloid protein aggregation characterizes many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Creutz- feldt-Jakob disease. Evidence suggests that amyloid aggregates may share similar aggregation pathways, implying simulation of full-length amyloid proteins is not necessary for understanding amyloid formation. In this study we simulate GNNQQNY, the N-terminal prion-determining domain of the yeast protein Sup35 to investigate the thermodynamics of structural transitions during aggregation. We use a coarse-grained model with replica-exchange molecular dynamics to investigate the association of 3-, 6-, and 12-chain GNNQQNY systems and we determine the aggregation pathway by studying aggregation states of GN- NQQNY. We find that the aggregation of the hydrophilic GNNQQNY sequence is mainly driven by H-bond formation, leading to the formation of /3-sheets from the very beginning of the assembly process. Condensation (aggregation) and ordering take place simultaneously, which is underpinned by the occurrence of a single heat capacity peak only.

  13. College education

    NASA Technical Reports Server (NTRS)

    Criswell, David R.

    1990-01-01

    Space Grant Colleges and Universities must build the space curriculum of the future on the firm basis of deep knowledge of an involvement with the present operating programs of the nation and an on-going and extensive program of leading edge research in the aerospace sciences and engineering, management, law, finance, and the other arts that are integral to our planetary society. The Space Grant College and Fellowship Program must create new academic fields of enquiry, which is a long and difficult process that will require deeper and broader interaction between NASA and academia than has previously existed.

  14. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 12 2013-07-01 2013-07-01 false Aggregate batch vent stream provisions... Resins § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph...

  15. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 11 2011-07-01 2011-07-01 false Aggregate batch vent stream provisions... § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph...

  16. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 12 2014-07-01 2014-07-01 false Aggregate batch vent stream provisions... Resins § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph...

  17. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Aggregate batch vent stream provisions... § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph...

  18. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 12 2012-07-01 2011-07-01 true Aggregate batch vent stream provisions... § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph...

  19. Aggregations in Flatworms.

    ERIC Educational Resources Information Center

    Liffen, C. L.; Hunter, M.

    1980-01-01

    Described is a school project to investigate aggregations in flatworms which may be influenced by light intensity, temperature, and some form of chemical stimulus released by already aggregating flatworms. Such investigations could be adopted to suit many educational levels of science laboratory activities. (DS)

  20. College Cambrian College Board of Governors Resource Manual.

    ERIC Educational Resources Information Center

    Barber, Paula; Lafrance, Glenys

    Intended as a resource manual for new and continuing governing board members of College Cambrian College (CCC) in Ontario, Canada, this five-part guide includes information on board member orientation; the Ontario College System (OCS); the history, mission and operations of CCC; activities, responsibilities, and tenure of board members; and…

  1. THE COLLEGE COMMISSIONS.

    ERIC Educational Resources Information Center

    FOOKS, JOYCE LANE

    THE HISTORIES, ORGANIZATIONAL STRUCTURES, MODES OF OPERATION, GOALS, AND SPECIFIC ACTIVITIES OF EIGHT COLLEGE SCIENCE COMMISSIONS ARE PRESENTED. THE GOAL OF THE EIGHT COLLEGE SCIENCE COMMISSIONS IS TO BRING UNDERGRADUATE SCIENCE INSTRUCTION CLOSER TO THE RESEARCH FRONTIER, UPDATE COURSES, AND FOSTER THE SPIRIT OF INQUIRY. INTERCOMMISSION…

  2. Challenge College, Bradford

    ERIC Educational Resources Information Center

    Flecknoe, Mervyn

    2004-01-01

    What can you expect from a school in an area of high crime where 50 percent of the pupils take free school meals and which operates on a site that cannot be accessed from its main catchment area? In this article, the author shares his experience when he visited Challenge College. A low wall separates Challenge College from the area where most of…

  3. Aggregate and the environment

    USGS Publications Warehouse

    Langer, William H.; Drew, Lawrence J.; Sachs, J.S.

    2004-01-01

    This book is designed to help you understand our aggregate resources-their importance, where they come from, how they are processed for our use, the environmental concerns related to their mining and processing, how those concerns are addressed, and the policies and regulations designed to safeguard workers, neighbors, and the environment from the negative impacts of aggregate mining. We hope this understanding will help prepare you to be involved in decisions that need to be made-individually and as a society-to be good stewards of our aggregate resources and our living planet.

  4. A Novel Method to Quantify Soil Aggregate Stability by Measuring Aggregate Bond Energies

    NASA Astrophysics Data System (ADS)

    Efrat, Rachel; Rawlins, Barry G.; Quinton, John N.; Watts, Chris W.; Whitmore, Andy P.

    2016-04-01

    Soil aggregate stability is a key indicator of soil quality because it controls physical, biological and chemical functions important in cultivated soils. Micro-aggregates are responsible for the long term sequestration of carbon in soil, therefore determine soils role in the carbon cycle. It is thus vital that techniques to measure aggregate stability are accurate, consistent and reliable, in order to appropriately manage and monitor soil quality, and to develop our understanding and estimates of soil as a carbon store to appropriately incorporate in carbon cycle models. Practices used to assess the stability of aggregates vary in sample preparation, operational technique and unit of results. They use proxies and lack quantification. Conflicting results are therefore drawn between projects that do not provide methodological or resultant comparability. Typical modern stability tests suspend aggregates in water and monitor fragmentation upon exposure to an un-quantified amount of ultrasonic energy, utilising a laser granulometer to measure the change in mean weight diameter. In this project a novel approach has been developed based on that of Zhu et al., (2009), to accurately quantify the stability of aggregates by specifically measuring their bond energies. The bond energies are measured operating a combination of calorimetry and a high powered ultrasonic probe, with computable output function. Temperature change during sonication is monitored by an array of probes which enables calculation of the energy spent heating the system (Ph). Our novel technique suspends aggregates in heavy liquid lithium heteropolytungstate, as opposed to water, to avoid exposing aggregates to an immeasurable disruptive energy source, due to cavitation, collisions and clay swelling. Mean weight diameter is measured by a laser granulometer to monitor aggregate breakdown after successive periods of calculated ultrasonic energy input (Pi), until complete dispersion is achieved and bond

  5. Report of Public Junior Colleges, FY74.

    ERIC Educational Resources Information Center

    Missouri State Dept. of Higher Education, Jefferson City.

    Brief narrative descriptions of the development of Missouri community colleges and the purposes and goals of the Missouri Department of Higher Education introduce the 17 tables of data pertinent to various aspects of Missouri junior colleges which make up the bulk of this report. An aggregate statement of income, expenditures, and physical assets…

  6. Protein Colloidal Aggregation Project

    NASA Technical Reports Server (NTRS)

    Oliva-Buisson, Yvette J. (Compiler)

    2014-01-01

    To investigate the pathways and kinetics of protein aggregation to allow accurate predictive modeling of the process and evaluation of potential inhibitors to prevalent diseases including cataract formation, chronic traumatic encephalopathy, Alzheimer's Disease, Parkinson's Disease and others.

  7. Before We're Up to Our Necks in Aggregators, Let's Get out Our Net "Value" Calculators!

    ERIC Educational Resources Information Center

    Butler, Lawrence

    2012-01-01

    No sooner has the Net Price Calculator (NPC) wave crashed ashore, the next wave of college-choice transparency in the form of third-party data aggregators is threatening to engulf American colleges and universities. Since last October, NPCs have become a fact of life for American colleges and universities. Some are doing the bare minimum to comply…

  8. Cell aggregation and sedimentation.

    PubMed

    Davis, R H

    1995-01-01

    The aggregation of cells into clumps or flocs has been exploited for decades in such applications as biological wastewater treatment, beer brewing, antibiotic fermentation, and enhanced sedimentation to aid in cell recovery or retention. More recent research has included the use of cell aggregation and sedimentation to selectively separate subpopulations of cells. Potential biotechnological applications include overcoming contamination, maintaining plasmid-bearing cells in continuous fermentors, and selectively removing nonviable hybridoma cells from perfusion cultures.

  9. A comparison of thermal zone aggregation methods

    SciTech Connect

    Dobbs, Justin R.; Hencey, Brandon M.

    2012-12-10

    The impact of increasing energy prices on building operation budgets has fueled demand for more energy-efficient structures. Existing building energy simulation tools generate an immense amount of data yet comparatively little knowledge. This paper introduces a framework that allows aggregation-based model reduction to operate on geometric building information models. The resulting aggregation sequence provides designers with faster simulations and affords insight into complex multi-scale thermal interactions. A comparison of the trade-off between simulation speed and accuracy for three hierarchical cluster partitioning methods concludes the discussion.

  10. Fibronectin Aggregation and Assembly

    PubMed Central

    Ohashi, Tomoo; Erickson, Harold P.

    2011-01-01

    The mechanism of fibronectin (FN) assembly and the self-association sites are still unclear and contradictory, although the N-terminal 70-kDa region (I1–9) is commonly accepted as one of the assembly sites. We previously found that I1–9 binds to superfibronectin, which is an artificial FN aggregate induced by anastellin. In the present study, we found that I1–9 bound to the aggregate formed by anastellin and a small FN fragment, III1–2. An engineered disulfide bond in III2, which stabilizes folding, inhibited aggregation, but a disulfide bond in III1 did not. A gelatin precipitation assay showed that I1–9 did not interact with anastellin, III1, III2, III1–2, or several III1–2 mutants including III1–2KADA. (In contrast to previous studies, we found that the III1–2KADA mutant was identical in conformation to wild-type III1–2.) Because I1–9 only bound to the aggregate and the unfolding of III2 played a role in aggregation, we generated a III2 domain that was destabilized by deletion of the G strand. This mutant bound I1–9 as shown by the gelatin precipitation assay and fluorescence resonance energy transfer analysis, and it inhibited FN matrix assembly when added to cell culture. Next, we introduced disulfide mutations into full-length FN. Three disulfide locks in III2, III3, and III11 were required to dramatically reduce anastellin-induced aggregation. When we tested the disulfide mutants in cell culture, only the disulfide bond in III2 reduced the FN matrix. These results suggest that the unfolding of III2 is one of the key factors for FN aggregation and assembly. PMID:21949131

  11. Reusing recycled aggregates in structural concrete

    NASA Astrophysics Data System (ADS)

    Kou, Shicong

    The utilization of recycled aggregates in concrete can minimize environmental impact and reduce the consumption of natural resources in concrete applications. The aim of this thesis is to provide a scientific basis for the possible use of recycled aggregates in structure concrete by conducting a comprehensive programme of laboratory study to gain a better understanding of the mechanical, microstructure and durability properties of concrete produced with recycled aggregates. The study also explored possible techniques to of improve the properties of recycled aggregate concrete that is produced with high percentages (≧ 50%) of recycled aggregates. These techniques included: (a) using lower water-to-cement ratios in the concrete mix design; (b) using fly ash as a cement replacement or as an additional mineral admixture in the concrete mixes, and (c) precasting recycled aggregate concrete with steam curing regimes. The characteristics of the recycled aggregates produced both from laboratory and a commercially operated pilot construction and demolition (C&D) waste recycling plant were first studied. A mix proportioning procedure was then established to produce six series of concrete mixtures using different percentages of recycled coarse aggregates with and without the use of fly ash. The water-to-cement (binder) ratios of 0.55, 0.50, 0.45 and 0.40 were used. The fresh properties (including slump and bleeding) of recycled aggregate concrete (RAC) were then quantified. The effects of fly ash on the fresh and hardened properties of RAC were then studied and compared with those RAC prepared with no fly ash addition. Furthermore, the effects of steam curing on the hardened properties of RAC were investigated. For micro-structural properties, the interfacial transition zones of the aggregates and the mortar/cement paste were analyzed by SEM and EDX-mapping. Moreover, a detailed set of results on the fracture properties for RAC were obtained. Based on the experimental

  12. Operational Amplifiers.

    ERIC Educational Resources Information Center

    Foxcroft, G. E.

    1986-01-01

    Addresses the introduction of low cost equipment into high school and college physical science classes. Examines the properties of an "ideal" operational amplifier and discusses how it might be used under saturated and non-saturated conditions. Notes the action of a "real" operational amplifier. (TW)

  13. Aggregate Remote Memory Copy Interface

    2006-02-23

    The purpose of the Aggregate Remote Memory Copy (ARMCI) library is to provide a general- purpose, efficient, and Widely portable remote memory access (RMA) operations (one-sided communication) optimized for Contiguous and noncontiguous (strided, scatter/gather, I/O vector) data transfers. In addition, ARMCI includes a set of atomic and mutual exclusion operations. The development ARMCI is driven by the need to support the global-addres space communication model in context of distributed regular or irregular distributed data structures,more » communication libraries, and compilers. ARMCI is a standalone system that could be used to support user-level libraries and applications that use MPI or PVM.« less

  14. Technology meets aggregate

    SciTech Connect

    Wilson, C.; Swan, C.

    2007-07-01

    New technology carried out at Tufts University and the University of Massachusetts on synthetic lightweight aggregate has created material from various qualities of fly ash from coal-fired power plants for use in different engineered applications. In pilot scale manufacturing tests an 'SLA' containing 80% fly ash and 20% mixed plastic waste from packaging was produced by 'dry blending' mixed plastic with high carbon fly ash. A trial run was completed to produce concrete masonry unit (CMU) blocks at a full-scale facility. It has been shown that SLA can be used as a partial substitution of a traditional stone aggregate in hot asphalt mix. 1 fig., 2 photos.

  15. A Comparison of Working Conditions Between Community College Instructors in Collective Bargaining Contract Colleges and Traditional Colleges.

    ERIC Educational Resources Information Center

    DePaoli, John A., Jr.

    In order to assess the impact of collective bargaining on community college faculty working conditions, a 79-item questionnaire was sent in winter 1974 to the presidents of a random nationwide sample of 100 community colleges operating under collective bargaining contracts and 100 community colleges operating under traditional agreements. Of the…

  16. Aggregates, broccoli and cauliflower

    NASA Astrophysics Data System (ADS)

    Grey, Francois; Kjems, Jørgen K.

    1989-09-01

    Naturally grown structures with fractal characters like broccoli and cauliflower are discussed and compared with DLA-type aggregates. It is suggested that the branching density can be used to characterize the growth process and an experimental method to determine this parameter is proposed.

  17. Illinois Community College Board Policy Manual.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    The fifth in a series of revised editions since 1967, this 1978 manual provides policy guidelines for Illinois public community colleges. Chapter 1 covers the state college board definitions relative to community college operations policy. Chapter 2 deals with board operation and general policies according to such topics as power and duties;…

  18. Custodial Operations: Green & Sustainable

    ERIC Educational Resources Information Center

    Campbell, J. Kirk

    2008-01-01

    Custodial Operations can have a significant impact on institutional green and sustainable goals if given the proper support and challenge. This article describes the green and sustainable custodial operations in place at Carleton College in Northfield, Minnesota. The article reviews the college's sustainable efforts on biodegradables, packaging,…

  19. Proteins aggregation and human diseases

    NASA Astrophysics Data System (ADS)

    Hu, Chin-Kun

    2015-04-01

    Many human diseases and the death of most supercentenarians are related to protein aggregation. Neurodegenerative diseases include Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), frontotemporallobar degeneration, etc. Such diseases are due to progressive loss of structure or function of neurons caused by protein aggregation. For example, AD is considered to be related to aggregation of Aβ40 (peptide with 40 amino acids) and Aβ42 (peptide with 42 amino acids) and HD is considered to be related to aggregation of polyQ (polyglutamine) peptides. In this paper, we briefly review our recent discovery of key factors for protein aggregation. We used a lattice model to study the aggregation rates of proteins and found that the probability for a protein sequence to appear in the conformation of the aggregated state can be used to determine the temperature at which proteins can aggregate most quickly. We used molecular dynamics and simple models of polymer chains to study relaxation and aggregation of proteins under various conditions and found that when the bending-angle dependent and torsion-angle dependent interactions are zero or very small, then protein chains tend to aggregate at lower temperatures. All atom models were used to identify a key peptide chain for the aggregation of insulin chains and to find that two polyQ chains prefer anti-parallel conformation. It is pointed out that in many cases, protein aggregation does not result from protein mis-folding. A potential drug from Chinese medicine was found for Alzheimer's disease.

  20. Dynamics of fire ant aggregations

    NASA Astrophysics Data System (ADS)

    Tennenbaum, Michael; Hu, David; Fernandez-Nieves, Alberto

    Fire ant aggregations are an inherently active system. Each ant harvests its own energy and can convert it into motion. The motion of individual ants contributes non-trivially to the bulk material properties of the aggregation. We have measured some of these properties using plate-plate rheology, where the response to an applied external force or deformation is measured. In this talk, we will present data pertaining to the aggregation behavior in the absence of any external force. We quantify the aggregation dynamics by monitoring the rotation of the top plate and by measuring the normal force. We then compare the results with visualizations of 2D aggregations.

  1. Probabilistic prediction models for aggregate quarry siting

    USGS Publications Warehouse

    Robinson, G.R.; Larkins, P.M.

    2007-01-01

    Weights-of-evidence (WofE) and logistic regression techniques were used in a GIS framework to predict the spatial likelihood (prospectivity) of crushed-stone aggregate quarry development. The joint conditional probability models, based on geology, transportation network, and population density variables, were defined using quarry location and time of development data for the New England States, North Carolina, and South Carolina, USA. The Quarry Operation models describe the distribution of active aggregate quarries, independent of the date of opening. The New Quarry models describe the distribution of aggregate quarries when they open. Because of the small number of new quarries developed in the study areas during the last decade, independent New Quarry models have low parameter estimate reliability. The performance of parameter estimates derived for Quarry Operation models, defined by a larger number of active quarries in the study areas, were tested and evaluated to predict the spatial likelihood of new quarry development. Population density conditions at the time of new quarry development were used to modify the population density variable in the Quarry Operation models to apply to new quarry development sites. The Quarry Operation parameters derived for the New England study area, Carolina study area, and the combined New England and Carolina study areas were all similar in magnitude and relative strength. The Quarry Operation model parameters, using the modified population density variables, were found to be a good predictor of new quarry locations. Both the aggregate industry and the land management community can use the model approach to target areas for more detailed site evaluation for quarry location. The models can be revised easily to reflect actual or anticipated changes in transportation and population features. ?? International Association for Mathematical Geology 2007.

  2. Kinetics of protein aggregation

    NASA Astrophysics Data System (ADS)

    Knowles, Tuomas

    2015-03-01

    Aggregation into linear nanostructures, notably amyloid and amyloid-like fibrils, is a common form of behaviour exhibited by a range of peptides and proteins. This process was initially discovered in the context of the aetiology of a range of neurodegenerative diseases, but has recently been recognised to of general significance and has been found at the origin of a number of beneficial functional roles in nature, including as catalytic scaffolds and functional components in biofilms. This talk discusses our ongoing efforts to study the kinetics of linear protein self-assembly by using master equation approaches combined with global analysis of experimental data.

  3. Structure of Viral Aggregates

    NASA Astrophysics Data System (ADS)

    Barr, Stephen; Luijten, Erik

    2010-03-01

    The aggregation of virus particles is a particular form of colloidal self-assembly, since viruses of a give type are monodisperse and have identical, anisotropic surface charge distributions. In small-angle X-ray scattering experiments, the Qbeta virus was found to organize in different crystal structures in the presence of divalent salt and non-adsorbing polymer. Since a simple isotropic potential cannot explain the occurrence of all observed phases, we employ computer simulations to investigate how the surface charge distribution affects the virus interactions. Using a detailed model of the virus particle, we find an asymmetric ion distribution around the virus which gives rise to the different phases observed.

  4. College Connection

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Scalzo, Mary Jo

    2012-01-01

    This article describes Oakwood City School District's College Connection Study, which is now in its eighth year. The purpose of the study is to help the educators in the district learn how to effectively prepare students for success in the colleges of their choice. Teachers, administrators, and other staff members travel to colleges to conduct…

  5. College Readiness

    ERIC Educational Resources Information Center

    Chapa, Marisa; Galvan-De Leon, Vanessa; Solis, Judith; Mundy, Marie-Anne

    2014-01-01

    During the 79th Texas Legislature, the bill "Advancement of College Readiness in Curriculum" was passed (THECB). As a response to this, high schools and colleges have combined forming an early college high school. The result of this union was a program that condensed the time it took to complete both the high school diploma and up to two…

  6. Taurine and platelet aggregation

    SciTech Connect

    Nauss-Karol, C.; VanderWende, C.; Gaut, Z.N.

    1986-03-01

    Taurine is a putative neurotransmitter or neuromodulator. The endogenous taurine concentration in human platelets, determined by amino acid analysis, is 15 ..mu..M/g. In spite of this high level, taurine is actively accumulated. Uptake is saturable, Na/sup +/ and temperature dependent, and suppressed by metabolic inhibitors, structural analogues, and several classes of centrally active substances. High, medium and low affinity transport processes have been characterized, and the platelet may represent a model system for taurine transport in the CNS. When platelets were incubated with /sup 14/C-taurine for 30 minutes, then resuspended in fresh medium and reincubated for one hour, essentially all of the taurine was retained within the cells. Taurine, at concentrations ranging from 10-1000 ..mu..M, had no effect on platelet aggregation induced by ADP or epinephrine. However, taurine may have a role in platelet aggregation since 35-39% of the taurine taken up by human platelets appears to be secreted during the release reaction induced by low concentrations of either epinephrine or ADP, respectively. This release phenomenon would imply that part of the taurine taken up is stored directly in the dense bodies of the platelet.

  7. Florida State Board of Education Administrative Rules for the Operation of Florida's Community/Junior Colleges, Chapter 6A-14. 1982 Edition.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee.

    Rules of the Florida State Department of Education that govern the administration of the state's community and junior colleges are presented. The rules cover absences, acceleration mechanisms, accounting, accountability, accreditation, admission requirements, adult general education, adult high schools, annual contracts, area served, athletic…

  8. Tentative Ten-Year Enrollment Projections, Fiscal Years 1978-1987. (A Supplement to the FY 1978 Capital and Operating Budgets of Montgomery Community College)

    ERIC Educational Resources Information Center

    Gell, Robert L.; Armstrong, David F.

    The number of students expected to enroll in Montgomery College yearly through 1987 is projected on the basis of a model incorporating past trends, population projections, economic indicators, and other factors on which viable assumptions about the future can be based, into a system of linear equations expressed in matrix notation. The model…

  9. Find Your College's Strategic Horizon

    ERIC Educational Resources Information Center

    Alfred, Richard L.

    2004-01-01

    Community colleges are experiencing tough times. As leaders watch the economy jump back to life and recognize this as a time of opportunity, they also realize that recovery in the public sector lags behind. Community colleges expecting to emerge from reduction stronger and better positioned will need to operate outside of a conventional business…

  10. Advancing the Community College Strategic Plan.

    ERIC Educational Resources Information Center

    Herbkersman, Neil; Hibbert-Jones, Karla

    2002-01-01

    Discusses the importance of developing a comprehensive grants development process to advance community college strategic plans, especially in the current economic climate. Details the process as developed and implemented by Sinclair Community College (Ohio). States that colleges that employ methodical processes and effective operating systems to…

  11. Survey of Writing Centers in Community Colleges.

    ERIC Educational Resources Information Center

    McKeague, Patricia M.; Reis, Elizabeth

    In 1990, Moraine Valley Community College conducted a study of writing centers at community colleges belonging to the League for Innovation in the Community College. The survey was designed to gather information on the staffing, facilities, services, operations, budget, and evaluation of writing centers. Questionnaires were sent to and returned by…

  12. THE ETHICS AND POLITICS OF COLLEGE PSYCHIATRY.

    ERIC Educational Resources Information Center

    SZASZ, THOMAS S.

    THE PRINCIPLES OF CONDUCT GOVERNING COLLEGE PSYCHIATRISTS AND THE RELATIONSHIPS BETWEEN THESE AUTHORITIES AND THEIR SUBJECTS ARE EXAMINED. MUCH OF THE WORK OF THE COLLEGE PSYCHIATRIST CONSISTS OF CRISIS INTERVENTION. THE COLLEGE PSYCHIATRIST OFTEN OPERATES AS BOTH A POLICE INTERROGATOR AND JUDGE. THE CHARACTERISTIC FEATURE OF HIS ROLE IS ITS…

  13. Holographic characterization of protein aggregates

    NASA Astrophysics Data System (ADS)

    Wang, Chen; Zhong, Xiao; Ruffner, David; Stutt, Alexandra; Philips, Laura; Ward, Michael; Grier, David

    Holographic characterization directly measures the size distribution of subvisible protein aggregates in suspension and offers insights into their morphology. Based on holographic video microscopy, this analytical technique records and interprets holograms of individual aggregates in protein solutions as they flow down a microfluidic channel, without requiring labeling or other exceptional sample preparation. The hologram of an individual protein aggregate is analyzed in real time with the Lorenz-Mie theory of light scattering to measure that aggregate's size and optical properties. Detecting, counting and characterizing subvisible aggregates proceeds fast enough for time-resolved studies, and lends itself to tracking trends in protein aggregation arising from changing environmental factors. No other analytical technique provides such a wealth of particle-resolved characterization data in situ. Holographic characterization promises accelerated development of therapeutic protein formulations, improved process control during manufacturing, and streamlined quality assurance during storage and at the point of use. Mrsec and MRI program of the NSF, Spheryx Inc.

  14. The Personal Protective Behaviors of College Student Drinkers: Evidence of Indigenous Protective Norms

    ERIC Educational Resources Information Center

    Haines, Michael P.; Barker, Gregory; Rice, Richard M.

    2006-01-01

    Given the prevalence of alcohol consumption and the relative infrequency of harm among college students, the authors sought to determine how most college students protect themselves from alcohol-related harm. An analysis of the aggregate National College Health Assessment data identified a cluster of personal protective behaviors that correlated…

  15. PRODUCTION OF CONSTRUCTION AGGREGATES FROM FLUE GAS DESULFURIZATION SLUDGE

    SciTech Connect

    M.M. Wu; D.C. McCoy; R.O. Scandrol; M.L. Fenger; J.A. Withum; R.M. Statnick

    2000-05-01

    The three main conclusions of this report are: (1) The pilot plant successfully demonstrated the continuous, fully-integrated, long-term process operation, including the mixing, pelletizing, and curing steps for aggregate production. The curing vessel, which was designed for the pilot plant test, was operated in a mass flow mode and performed well during pilot plant operation. (2) The pilot plant test demonstrated process flexibility. The same equipment was used to produce lightweight, medium-weight, and road aggregates. The only change was the mix formulation. Aggregates were produced from a variety of mix designs and from FGD sludge with solids concentrations between 45.0% and 56.7% and moisture contents between 55.0% and 43.3%. (3) The pilot plant provided operating data and experience to design and cost a commercial plant, which was not part of the cooperative agreement.

  16. Houston Community College (HCC)-Mobile Go Center Program

    ERIC Educational Resources Information Center

    Ramirez, Daniel; Sterling, Cheryl; Grays, Shantay R.

    2010-01-01

    The Houston Community College Mobile Go Center brings college enrollment assistance to the doorstep of our community. It operates in a variety of settings, offering college-going material and person-to-person assistance at numerous city events. Services include assistance with academic advising, completing the FAFSA, college application process,…

  17. Peptide aggregation in neurodegenerative disease.

    PubMed

    Murphy, Regina M

    2002-01-01

    In the not-so-distant past, insoluble aggregated protein was considered as uninteresting and bothersome as yesterday's trash. More recently, protein aggregates have enjoyed considerable scientific interest, as it has become clear that these aggregates play key roles in many diseases. In this review, we focus attention on three polypeptides: beta-amyloid, prion, and huntingtin, which are linked to three feared neurodegenerative diseases: Alzheimer's, "mad cow," and Huntington's disease, respectively. These proteins lack any significant primary sequence homology, yet their aggregates possess very similar features, specifically, high beta-sheet content, fibrillar morphology, relative insolubility, and protease resistance. Because the aggregates are noncrystalline, secrets of their structure at nanometer resolution are only slowly yielding to X-ray diffraction, solid-state NMR, and other techniques. Besides structure, the aggregates may possess similar pathways of assembly. Two alternative assembly pathways have been proposed: the nucleation-elongation and the template-assisted mode. These two modes may be complementary, not mutually exclusive. Strategies for interfering with aggregation, which may provide novel therapeutic approaches, are under development. The structural similarities between protein aggregates of dissimilar origin suggest that therapeutic strategies successful against one disease may have broad utility in others. PMID:12117755

  18. Topics in Probabilistic Judgment Aggregation

    ERIC Educational Resources Information Center

    Wang, Guanchun

    2011-01-01

    This dissertation is a compilation of several studies that are united by their relevance to probabilistic judgment aggregation. In the face of complex and uncertain events, panels of judges are frequently consulted to provide probabilistic forecasts, and aggregation of such estimates in groups often yield better results than could have been made…

  19. Mineral of the month: aggregates

    USGS Publications Warehouse

    Tepordei, Valentin V.

    2005-01-01

    Natural aggregates, consisting of crushed stone, and sand and gravel, are a major contributor to economic health, and have an amazing variety of uses. Aggregates are among the most abundant mineral resources and are major basic raw materials used by construction, agriculture and other industries that employ complex chemical and metallurgical processes.

  20. Molecular aggregation of humic substances

    USGS Publications Warehouse

    Wershaw, R. L.

    1999-01-01

    Humic substances (HS) form molecular aggregates in solution and on mineral surfaces. Elucidation of the mechanism of formation of these aggregates is important for an understanding of the interactions of HS in soils arid natural waters. The HS are formed mainly by enzymatic depolymerization and oxidation of plant biopolymers. These reactions transform the aromatic and lipid plant components into amphiphilic molecules, that is, molecules that consist of separate hydrophobic (nonpolar) and hydrophilic (polar) parts. The nonpolar parts of the molecules are composed of relatively unaltered segments of plant polymers and the polar parts of carboxylic acid groups. These amphiphiles form membrane-like aggregates on mineral surfaces and micelle-like aggregates in solution. The exterior surfaces of these aggregates are hydrophilic, and the interiors constitute separate hydrophobic liquid-like phases.

  1. Nanoparticle aggregation: principles and modeling.

    PubMed

    Zhang, Wen

    2014-01-01

    The high surface area to volume ratio of nanoparticles usually results in highly reactive and colloidal instability compared to their bulk counterparts. Aggregation as well as many other transformations (e.g., dissolution) in the environment may alter the physiochemical properties, reactivity, fate, transport, and biological interactions (e.g., bioavailability and uptake) of nanoparticles. The unique properties pertinent to nanoparticles, such as shape, size, surface characteristics, composition, and electronic structures, greatly challenge the ability of colloid science to understand nanoparticle aggregation and its environmental impacts. This review briefly introduces fundamentals about aggregation, fractal dimensions, classic and extended Derjaguin-Landau-Verwey-Overbeak (DLVO) theories, aggregation kinetic modeling, experimental measurements, followed by detailed discussions on the major factors on aggregation and subsequent effects on nanomaterial transport and reactivity.

  2. Immunogenicity of Therapeutic Protein Aggregates.

    PubMed

    Moussa, Ehab M; Panchal, Jainik P; Moorthy, Balakrishnan S; Blum, Janice S; Joubert, Marisa K; Narhi, Linda O; Topp, Elizabeth M

    2016-02-01

    Therapeutic proteins have a propensity for aggregation during manufacturing, shipping, and storage. The presence of aggregates in protein drug products can induce adverse immune responses in patients that may affect safety and efficacy, and so it is of concern to both manufacturers and regulatory agencies. In this vein, there is a lack of understanding of the physicochemical determinants of immunological responses and a lack of standardized analytical methods to survey the molecular properties of aggregates associated with immune activation. In this review, we provide an overview of the basic immune mechanisms in the context of interactions with protein aggregates. We then critically examine the literature with emphasis on the underlying immune mechanisms as they relate to aggregate properties. Finally, we highlight the gaps in our current understanding of this issue and offer recommendations for future research. PMID:26869409

  3. Mechanics of fire ant aggregations

    NASA Astrophysics Data System (ADS)

    Tennenbaum, Michael; Liu, Zhongyang; Hu, David; Fernandez-Nieves, Alberto

    2016-01-01

    Fire ants link their bodies to form aggregations; these can adopt a variety of structures, they can drip and spread, or withstand applied loads. Here, by using oscillatory rheology, we show that fire ant aggregations are viscoelastic. We find that, at the lowest ant densities probed and in the linear regime, the elastic and viscous moduli are essentially identical over the spanned frequency range, which highlights the absence of a dominant mode of structural relaxation. As ant density increases, the elastic modulus rises, which we interpret by alluding to ant crowding and subsequent jamming. When deformed beyond the linear regime, the aggregation flows, exhibiting shear-thinning behaviour with a stress load that is comparable to the maximum load the aggregation can withstand before individual ants are torn apart. Our findings illustrate the rich, collective mechanical behaviour that can arise in aggregations of active, interacting building blocks.

  4. Mechanics of fire ant aggregations.

    PubMed

    Tennenbaum, Michael; Liu, Zhongyang; Hu, David; Fernandez-Nieves, Alberto

    2016-01-01

    Fire ants link their bodies to form aggregations; these can adopt a variety of structures, they can drip and spread, or withstand applied loads. Here, by using oscillatory rheology, we show that fire ant aggregations are viscoelastic. We find that, at the lowest ant densities probed and in the linear regime, the elastic and viscous moduli are essentially identical over the spanned frequency range, which highlights the absence of a dominant mode of structural relaxation. As ant density increases, the elastic modulus rises, which we interpret by alluding to ant crowding and subsequent jamming. When deformed beyond the linear regime, the aggregation flows, exhibiting shear-thinning behaviour with a stress load that is comparable to the maximum load the aggregation can withstand before individual ants are torn apart. Our findings illustrate the rich, collective mechanical behaviour that can arise in aggregations of active, interacting building blocks. PMID:26501413

  5. Adsorption-induced colloidal aggregation

    NASA Astrophysics Data System (ADS)

    Law, B. M.; Petit, J.-M.; Beysens, D.

    1998-03-01

    Reversible colloidal aggregation in binary liquid mixtures has been studied for a number of years. As the phase separation temperature of the liquid mixture is approached the thickness of an adsorption layer around the colloidal particles increases. Beysens and coworkers have demonstrated experimentally that this adsorption layer is intimately connected with the aggregation of the colloidal particles, however, no definitive theory has been available which can explain all of the experimental observations. In this contribution we describe an extension of the Derjaguin, Landau, Verwey, and Overbeek theory of colloidal aggregation which takes into account the presence of the adsorption layer and which more realistically models the attractive dispersion interactions. This modified theory can quantitatively account for many of the observed experimental features such as the characteristics of the aggregated state, the general shape of the aggregation line, and the temperature dependence of the second virial coefficient for a lutidine-water mixture containing a small volume fraction of silica colloidal particles.

  6. Dataset of aggregate producers in New Mexico

    USGS Publications Warehouse

    Orris, Greta J.

    2000-01-01

    This report presents data, including latitude and longitude, for aggregate sites in New Mexico that were believed to be active in the period 1997-1999. The data are presented in paper form in Part A of this report and as Microsoft Excel 97 and Data Interchange Format (DIF) files in Part B. The work was undertaken as part of the effort to update information for the National Atlas. This compilation includes data from: the files of U.S. Geological Survey (USGS); company contacts; the New Mexico Bureau of Mines and Mineral Resources, New Mexico Bureau of Mine Inspection, and the Mining and Minerals Division of the New Mexico Energy, Minerals and Natural Resources Department (Hatton and others, 1998); the Bureau of Land Management Information; and direct communications with some of the aggregate operators. Additional information on most of the sites is available in Hatton and others (1998).

  7. Distance and Intrastate College Student Migration

    ERIC Educational Resources Information Center

    Alm, James; Winters, John V.

    2009-01-01

    Most studies of student migration focus on "interstate" migration of college students, largely because the aggregate data typically used are limited in geographic specificity to states. However, interstate migration is only a small part of the total student migration. Public institutions generally get most of their students from within their…

  8. Privacy-Preserving Data Aggregation in Two-Tiered Wireless Sensor Networks with Mobile Nodes

    PubMed Central

    Yao, Yonglei; Liu, Jingfa; Xiong, Neal N.

    2014-01-01

    Privacy-preserving data aggregation in wireless sensor networks (WSNs) with mobile nodes is a challenging problem, as an accurate aggregation result should be derived in a privacy-preserving manner, under the condition that nodes are mobile and have no pre-specified keys for cryptographic operations. In this paper, we focus on the SUM aggregation function and propose two privacy-preserving data aggregation protocols for two-tiered sensor networks with mobile nodes: Privacy-preserving Data Aggregation against non-colluded Aggregator and Sink (PDAAS) and Privacy-preserving Data Aggregation against Colluded Aggregator and Sink (PDACAS). Both protocols guarantee that the sink can derive the SUM of all raw sensor data but each sensor's raw data is kept confidential. In PDAAS, two keyed values are used, one shared with the sink and the other shared with the aggregator. PDAAS can protect the privacy of sensed data against external eavesdroppers, compromised sensor nodes, the aggregator or the sink, but fails if the aggregator and the sink collude. In PDACAS, multiple keyed values are used in data perturbation, which are not shared with the aggregator or the sink. PDACAS can protect the privacy of sensor nodes even the aggregator and the sink collude, at the cost of a little more overhead than PDAAS. Thorough analysis and experiments are conducted, which confirm the efficacy and efficiency of both schemes. PMID:25390407

  9. Role of Standard Demand Response Signals for Advanced Automated Aggregation

    SciTech Connect

    Lawrence Berkeley National Laboratory; Kiliccote, Sila

    2011-11-18

    Emerging standards such as OpenADR enable Demand Response (DR) Resources to interact directly with Utilities and Independent System Operators to allow their facility automation equipment to respond to a variety of DR signals ranging from day ahead to real time ancillary services. In addition, there are Aggregators in today’s markets who are capable of bringing together collections of aggregated DR assets and selling them to the grid as a single resource. However, in most cases these aggregated resources are not automated and when they are, they typically use proprietary technologies. There is a need for a framework for dealing with aggregated resources that supports the following requirements: • Allows demand-side resources to participate in multiple DR markets ranging from wholesale ancillary services to retail tariffs without being completely committed to a single entity like an Aggregator; • Allow aggregated groups of demand-side resources to be formed in an ad hoc fashion to address specific grid-side issues and support the optimization of the collective response of an aggregated group along a number of different dimensions. This is important in order to taylor the aggregated performance envelope to the needs to of the grid; • Allow aggregated groups to be formed in a hierarchical fashion so that each group can participate in variety of markets from wholesale ancillary services to distribution level retail tariffs. This paper explores the issues of aggregated groups of DR resources as described above especially within the context of emerging smart grid standards and the role they will play in both the management and interaction of various grid-side entities with those resources.

  10. Community Colleges. The Boston Junior College Blues

    ERIC Educational Resources Information Center

    Papke, David Ray

    1975-01-01

    Private junior colleges for women in Boston are suffering from severe financial difficulties. The solutions at three schools, Garland Junior College, Pine Manor Junior College, and Mount Ida Junior College, are presented. (Author/PG)

  11. Scalable evaluation of platelet aggregation by the degree of blood migration

    NASA Astrophysics Data System (ADS)

    Song, Suk-Heung; Lim, Chae-Seung; Shin, Sehyun

    2013-12-01

    Platelet aggregation plays a key role in vascular thrombosis. Antiplatelet drug therapy is commonly used for the prevention of abnormal platelet aggregation. So, measuring platelet aggregation function is critically important in clinical field. Here, we introduce a scalable evaluation method of platelet aggregation measured with the degree of blood migration through microchannel in a microfluidic chip. Unlike conventional methods that require expertise with system physics to operate devices, our approach is using microfluidics system, which requires only a syringe vacuum. The scalable migration factors, migration distance and touchdown time, are capable of distinguishing various antiplatelet drug effects under microfluidics and would be effective for the quick and easy evaluation of quantitative platelet aggregation.

  12. Navigating College

    ERIC Educational Resources Information Center

    Arum, Richard

    2016-01-01

    Students moving from high school to college in the United States typically confront a bewildering set of largely unstructured options. In the absence of clear signals about how to get the most out of college, they often choose pathways that involve limited academic rigor and engagement. In this article, Richard Arum describes a study that followed…

  13. College Radio.

    ERIC Educational Resources Information Center

    Sauls, Samuel J.

    As with commercial stations, the underlying premise of the college radio station is to serve the community, whether it be the campus community or the community at large, but in unique ways often geared to underserved niches of the population. Much of college radio's charm lies in its unpredictable nature and constant mutations. The stations give…

  14. Electoral College.

    ERIC Educational Resources Information Center

    Goldstein, Joel K.

    1996-01-01

    Examines one of the least understood institutions of U.S. politics, the Electoral College. Discusses the historical circumstances resulting in its creation as well as the current structure and membership. Provides arguments for and against continuation of the Electoral College. (MJP)

  15. College Calendars.

    ERIC Educational Resources Information Center

    Larsson, Robert D.

    In order to determine whether there were compelling reasons for Schenectady County Community College (SCCC) to change its quarter calendar, and which calendar would be most appropriate to the college and most responsive to the problems that made the change seem desirable, previous calendar change studies were reviewed and administrators of…

  16. Secure data aggregation in wireless sensor networks using homomorphic encryption

    NASA Astrophysics Data System (ADS)

    Kumar, Manish; Verma, Shekhar; Lata, Kusum

    2015-04-01

    In a Wireless Sensor Network (WSN), aggregation exploits the correlation between spatially and temporally proximate sensor data to reduce the total data volume to be transmitted to the sink. Mobile agents (MAs) fit into this paradigm, and data can be aggregated and collected by an MA from different sensor nodes using context specific codes. The MA-based data collection suffers due to large size of a typical WSN and is prone to security problems. In this article, homomorphic encryption in a clustered WSN has been proposed for secure and efficient data collection using MAs. The nodes keep encrypted data that are given to an MA for data aggregation tasks. The MA performs all the data aggregation operations upon encrypted data as it migrates between nodes in a tree-like structure in which the nodes are leafs and the cluster head is the root of the tree. It returns and deposits the encrypted aggregated data to the cluster head after traversing through all the intra cluster nodes over a shortest path route. The homomorphic encryption and aggregation processing in encrypted domain makes the data collection process secure. Simulation results confirm the effectiveness of the proposed secure data aggregation mechanism. In addition to security, MA-based mechanism leads to lesser delay and bandwidth requirements.

  17. Fractal aggregates in Titan's atmosphere

    NASA Astrophysics Data System (ADS)

    Cabane, M.; Rannou, P.; Chassefiere, E.; Israel, G.

    1993-04-01

    The cluster structure of Titan's atmosphere was modeled by using an Eulerian microphysical model with the specific formulation of microphysical laws applying to fractal particles. The growth of aggregates in the settling phase was treated by introducing the fractal dimension as a parameter of the model. The model was used to obtain a vertical distribution of size and number density of the aggregates for different production altitudes. Results confirm previous estimates of the formation altitude of photochemical aerosols. The vertical profile of the effective radius of aggregates was calculated as a function of the visible optical depth.

  18. Ceramic roadway aggregates with improved polish and wear resistance

    NASA Astrophysics Data System (ADS)

    Petty, A. V., Jr.

    1981-08-01

    Synthetic ceramic aggregates having high wear- and polish-resistance were developed. Three hundred aggregate compositions, incorporating a variety of low-cost 'waste' materials were evaluated. Aggregates were produced using conventional ceramic processing techniques and fired at temperatures ranging from 900-1,500 C. British Wheel and L. A. Abrasion tests were used for initial screening of the aggregates. These data, raw material costs, availability, and energy requirements, were used to select nine compositions for circular track tests. Economic evaluations showed that present production costs, based on a 1,000 ton-per-day operation ranged from $10 to $120 per ton of material produced. Guyana bauxite was used as a standard.

  19. Surface fractals in liposome aggregation.

    PubMed

    Roldán-Vargas, Sándalo; Barnadas-Rodríguez, Ramon; Quesada-Pérez, Manuel; Estelrich, Joan; Callejas-Fernández, José

    2009-01-01

    In this work, the aggregation of charged liposomes induced by magnesium is investigated. Static and dynamic light scattering, Fourier-transform infrared spectroscopy, and cryotransmission electron microscopy are used as experimental techniques. In particular, multiple intracluster scattering is reduced to a negligible amount using a cross-correlation light scattering scheme. The analysis of the cluster structure, probed by means of static light scattering, reveals an evolution from surface fractals to mass fractals with increasing magnesium concentration. Cryotransmission electron microscopy micrographs of the aggregates are consistent with this interpretation. In addition, a comparative analysis of these results with those previously reported in the presence of calcium suggests that the different hydration energy between lipid vesicles when these divalent cations are present plays a fundamental role in the cluster morphology. This suggestion is also supported by infrared spectroscopy data. The kinetics of the aggregation processes is also analyzed through the time evolution of the mean diffusion coefficient of the aggregates. PMID:19257067

  20. Surface fractals in liposome aggregation.

    PubMed

    Roldán-Vargas, Sándalo; Barnadas-Rodríguez, Ramon; Quesada-Pérez, Manuel; Estelrich, Joan; Callejas-Fernández, José

    2009-01-01

    In this work, the aggregation of charged liposomes induced by magnesium is investigated. Static and dynamic light scattering, Fourier-transform infrared spectroscopy, and cryotransmission electron microscopy are used as experimental techniques. In particular, multiple intracluster scattering is reduced to a negligible amount using a cross-correlation light scattering scheme. The analysis of the cluster structure, probed by means of static light scattering, reveals an evolution from surface fractals to mass fractals with increasing magnesium concentration. Cryotransmission electron microscopy micrographs of the aggregates are consistent with this interpretation. In addition, a comparative analysis of these results with those previously reported in the presence of calcium suggests that the different hydration energy between lipid vesicles when these divalent cations are present plays a fundamental role in the cluster morphology. This suggestion is also supported by infrared spectroscopy data. The kinetics of the aggregation processes is also analyzed through the time evolution of the mean diffusion coefficient of the aggregates.

  1. Electromagnetic charges in aggregation phenomena.

    NASA Astrophysics Data System (ADS)

    Rioux, Claude; Slobodrian, R. J.

    Introduction The mechanism of fine particles aggregation is of great importance in many areas of research, in particular environment sciences where the state of aggregation defines the removal speed of dust from the atmosphere. The study of this mechanism is also important to understand the first stage of planet formation from the solar nebula. The aggregates formed are generally fractals and, as mentioned in the literature [1], the fractal dimensions and the site growth probability measures of the resulting fractal structures strongly depend on the properties of the forces that cause the aggregation. Theory and experimental apparatus We began this study by the aggregation between two charged particles and we are now consid-ering the aggregation between two magnetized particles. The aggregations are produced in a gas at a pressure between 10 and 1000 mbar and by using the applicable simplifications; we find that the distance (r) between the particles as a function of time (t) is given by the following equations: r=Ce(tf -t)1/3 for the electrical attraction r=Cm(tf -t)1/5 for the magnetic dipoles aligned in an external magnetic field. The apparatus built for these measurements consists of an experimental cell from which two perpendicular views are combined via an optical system in one image recorded by a video camera. From the video, we can then measure the distance between the particles as a function of time and reconstruct the trajectories in 3-D. The horizontal and vertical resolutions are respectively 0.86 and 0.92 microns per pixel. With a depth of field of 250 microns, the usable volume for 3-D observation in then 250 microns x 250 microns x 443 microns. Results and discussion A first version of the apparatus was tested on an electrical force aggregation and the results [2] show that the corresponding equation is a good representation of the phenomenon. Preliminary results, from an experiment using iron particles, show that the magnetic force can be seen in

  2. Aggregate breakdown of nanoparticulate titania

    NASA Astrophysics Data System (ADS)

    Venugopal, Navin

    Six nanosized titanium dioxide powders synthesized from a sulfate process were investigated. The targeted end-use of this powder was for a de-NOx catalyst honeycomb monolith. Alteration of synthesis parameters had resulted principally in differences in soluble ion level and specific surface area of the powders. The goal of this investigation was to understand the role of synthesis parameters in the aggregation behavior of these powders. Investigation via scanning electron microscopy of the powders revealed three different aggregation iterations at specific length scales. Secondary and higher order aggregate strength was investigated via oscillatory stress rheometry as a means of simulating shear conditions encountered during extrusion. G' and G'' were measured as a function of the applied oscillatory stress. Oscillatory rheometry indicated a strong variation as a function of the sulfate level of the particles in the viscoelastic yield strengths. Powder yield stresses ranged from 3.0 Pa to 24.0 Pa of oscillatory stress. Compaction curves to 750 MPa found strong similarities in extrapolated yield point of stage I and II compaction for each of the powders (at approximately 500 MPa) suggesting that the variation in sulfate was greatest above the primary aggregate level. Scanning electron microscopy of samples at different states of shear in oscillatory rheometry confirmed the variation in the linear elastic region and the viscous flow regime. A technique of this investigation was to approach aggregation via a novel perspective: aggregates are distinguished as being loose open structures that are highly disordered and stochastic in nature. The methodology used was to investigate the shear stresses required to rupture the various aggregation stages encountered and investigate the attempt to realign the now free-flowing constituents comprising the aggregate into a denser configuration. Mercury porosimetry was utilized to measure the pore size of the compact resulting from

  3. Is Community College Really College?

    ERIC Educational Resources Information Center

    Blankenship, Mark

    2011-01-01

    There are a lot of misconceptions when it comes to community college. The general population appears to believe that because the tuition per credit hour is incredibly cheaper than that of the average university, students are receiving a "discounted," "cheap," "rip-off" education. Top community college students struggle against the mistaken…

  4. Glycation precedes lens crystallin aggregation

    SciTech Connect

    Swamy, M.S.; Perry, R.E.; Abraham, E.C.

    1987-05-01

    Non-enzymatic glycosylation (glycation) seems to have the potential to alter the structure of crystallins and make them susceptible to thiol oxidation leading to disulfide-linked high molecular weight (HMW) aggregate formation. They used streptozotocin diabetic rats during precataract and cataract stages and long-term cell-free glycation of bovine lens crystallins to study the relationship between glycation and lens crystallin aggregation. HMW aggregates and other protein components of the water-soluble (WS) and urea-soluble (US) fractions were separated by molecular sieve high performance liquid chromatography. Glycation was estimated by both (/sup 3/H)NaBH/sub 4/ reduction and phenylboronate agarose affinity chromatography. Levels of total glycated protein (GP) in the US fractions were about 2-fold higher than in the WS fractions and there was a linear increase in GP in both WS and US fractions. This increase was parallelled by a corresponding increase in HMW aggregates. Total GP extracted by the affinity method from the US fraction showed a predominance of HMW aggregates and vice versa. Cell-free glycation studies with bovine crystallins confirmed the results of the animals studies. Increasing glycation caused a corresponding increase in protein insolubilization and the insoluble fraction thus formed also contained more glycated protein. It appears that lens protein glycation, HMW aggregate formation, and protein insolubilization are interrelated.

  5. 40 CFR 63.1205 - What are the standards for hazardous waste burning lightweight aggregate kilns that are effective...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... waste burning lightweight aggregate kilns that are effective until compliance with the standards under Â... Emissions Standards and Operating Limits for Incinerators, Cement Kilns, and Lightweight Aggregate Kilns § 63.1205 What are the standards for hazardous waste burning lightweight aggregate kilns that...

  6. Dye-sensitized solar cell employing zinc oxide aggregates grown in the presence of lithium

    DOEpatents

    Zhang, Qifeng; Cao, Guozhong

    2013-10-15

    Provided are a novel ZnO dye-sensitized solar cell and method of fabricating the same. In one embodiment, deliberately added lithium ions are used to mediate the growth of ZnO aggregates. The use of lithium provides ZnO aggregates that have advantageous microstructure, morphology, crystallinity, and operational characteristics. Employing lithium during aggregate synthesis results in a polydisperse collection of ZnO aggregates favorable for porosity and light scattering. The resulting nanocrystallites forming the aggregates have improved crystallinity and more favorable facets for dye molecule absorption. The lithium synthesis improves the surface stability of ZnO in acidic dyes. The procedures developed and disclosed herein also help ensure the formation of an aggregate film that has a high homogeneity of thickness, a high packing density, a high specific surface area, and good electrical contact between the film and the fluorine-doped tin oxide electrode and among the aggregate particles.

  7. Crystal aggregation in kidney stones; a polymer aggregation problem?

    NASA Astrophysics Data System (ADS)

    Wesson, J.; Beshensky, A.; Viswanathan, P.; Zachowicz, W.; Kleinman, J.

    2008-03-01

    Kidney stones most frequently form as aggregates of calcium oxalate monohydrate (COM) crystals with organic layers between them, and the organic layers contain principally proteins. The pathway leading to the formation of these crystal aggregates in affected people has not been identified, but stone forming patients are thought to have a defect in the structure or distribution of urinary proteins, which normally protect against stone formation. We have developed two polyelectrolyte models that will induce COM crystal aggregation in vitro, and both are consistent with possible urinary protein compositions. The first model was based on mixing polyanionic and polycationic proteins, in portions such that the combined protein charge is near zero. The second model was based on reducing the charge density on partially charged polyanionic proteins, specifically Tamm-Horsfall protein, the second most abundant protein in urine. Both models demonstrated polymer phase separation at solution conditions where COM crystal aggregation was observed. Correlation with data from other bulk crystallization measurements suggest that the anionic side chains form critical binding interactions with COM surfaces that are necessary along with the phase separation process to induce COM crystal aggregation.

  8. Production of manufactured aggregates from flue gas desulfurization by-products

    SciTech Connect

    Wu, M.M.; McCoy, D.C.; Fenger, M.L.; Scandrol, R.O.; Winschel, R.A.; Withum, J.A.; Statnick, R.M.

    1999-07-01

    CONSOL R and D has developed a disk pelletization process to produce manufactured aggregates from the by-products of various technologies designed to reduce sulfur emissions produced from coal utilization. Aggregates have been produced from the by-products of the Coolside and LIMB sorbent injection, the fluidized-bed combustion (FBC), spray dryer absorption (SDA), and lime and limestone wet flue gas desulfurization (FGD) processes. The aggregates produced meet the general specifications for use as road aggregate in road construction and for use as lightweight aggregate in concrete masonry units. Small field demonstrations with 1200 lb to 5000 lb of manufactured aggregates were conducted using aggregates produced from FBC ash and lime wet FGD sludge in road construction and using aggregates made from SDA ash and lime wet FGD sludge to manufacture concrete blocks. The aggregates for this work were produced with a bench-scale (200--400 lb batch) unit. In 1999, CONSOL R and D constructed and operated a 500 lb/hr integrated, continuous pilot plant. A variety of aggregate products were produced from lime wet FGD sludge. The pilot plant test successfully demonstrated the continuous, integrated operation of the process. The pilot plant demonstration was a major step toward commercialization of manufactured aggregate production from FGD by-products. In this paper, progress made in the production of aggregates from dry FGD (Coolside, LIMB, SDA) and FBC by-products, and lime wet FGD sludge is discussed. The discussion covers bench-scale and pilot plant aggregate production and aggregate field demonstrations.

  9. Unmarried parents in college.

    PubMed

    Goldrick-Rab, Sara; Sorensen, Kia

    2010-01-01

    Noting that access to higher education has expanded dramatically in the past several decades, Sara Goldrick-Rab and Kia Sorensen focus on how unmarried parents fare once they enter college. Contrary to the expectation that access to college consistently promotes family stability and economic security, the authors argue that deficiencies in current policy lead college attendance to have adverse consequences for some families headed by unmarried parents. Although rates of college attendance have increased substantially among unmarried parents, their college completion rates are low. One explanation is inadequate academic preparation. Another is financial constraints, which can force unmarried students to interrupt their studies or increase their work hours, both of which compromise the quality of their educational experiences and the outcomes for their children. The authors point out that although many public programs offer support to unmarried parents attending college, the support is neither well coordinated nor easily accessed. Over the past three decades, loans have increasingly replaced grants as the most common form of federal and state financial aid. Confusion about what is available leads many low-income students to the two most "straightforward" sources of income--loans and work, both of which involve significant costs and can operate at cross-purposes with public forms of support. Too much work can lead to reductions in public benefits, and earnings do not always replace the lost income. A growing body of experimental evidence shows that providing social, financial, and academic supports to vulnerable community college students can improve achievement and attainment. Contextualized learning programs, for example, have enabled participants not only to move on from basic skills to credit-bearing coursework, but also to complete credits, earn certificates, and make gains on basic skills tests. Another successful initiative provided low-performing students with

  10. Unmarried parents in college.

    PubMed

    Goldrick-Rab, Sara; Sorensen, Kia

    2010-01-01

    Noting that access to higher education has expanded dramatically in the past several decades, Sara Goldrick-Rab and Kia Sorensen focus on how unmarried parents fare once they enter college. Contrary to the expectation that access to college consistently promotes family stability and economic security, the authors argue that deficiencies in current policy lead college attendance to have adverse consequences for some families headed by unmarried parents. Although rates of college attendance have increased substantially among unmarried parents, their college completion rates are low. One explanation is inadequate academic preparation. Another is financial constraints, which can force unmarried students to interrupt their studies or increase their work hours, both of which compromise the quality of their educational experiences and the outcomes for their children. The authors point out that although many public programs offer support to unmarried parents attending college, the support is neither well coordinated nor easily accessed. Over the past three decades, loans have increasingly replaced grants as the most common form of federal and state financial aid. Confusion about what is available leads many low-income students to the two most "straightforward" sources of income--loans and work, both of which involve significant costs and can operate at cross-purposes with public forms of support. Too much work can lead to reductions in public benefits, and earnings do not always replace the lost income. A growing body of experimental evidence shows that providing social, financial, and academic supports to vulnerable community college students can improve achievement and attainment. Contextualized learning programs, for example, have enabled participants not only to move on from basic skills to credit-bearing coursework, but also to complete credits, earn certificates, and make gains on basic skills tests. Another successful initiative provided low-performing students with

  11. Fractal Aggregates in Tennis Ball Systems

    ERIC Educational Resources Information Center

    Sabin, J.; Bandin, M.; Prieto, G.; Sarmiento, F.

    2009-01-01

    We present a new practical exercise to explain the mechanisms of aggregation of some colloids which are otherwise not easy to understand. We have used tennis balls to simulate, in a visual way, the aggregation of colloids under reaction-limited colloid aggregation (RLCA) and diffusion-limited colloid aggregation (DLCA) regimes. We have used the…

  12. Aggregated Recommendation through Random Forests

    PubMed Central

    2014-01-01

    Aggregated recommendation refers to the process of suggesting one kind of items to a group of users. Compared to user-oriented or item-oriented approaches, it is more general and, therefore, more appropriate for cold-start recommendation. In this paper, we propose a random forest approach to create aggregated recommender systems. The approach is used to predict the rating of a group of users to a kind of items. In the preprocessing stage, we merge user, item, and rating information to construct an aggregated decision table, where rating information serves as the decision attribute. We also model the data conversion process corresponding to the new user, new item, and both new problems. In the training stage, a forest is built for the aggregated training set, where each leaf is assigned a distribution of discrete rating. In the testing stage, we present four predicting approaches to compute evaluation values based on the distribution of each tree. Experiments results on the well-known MovieLens dataset show that the aggregated approach maintains an acceptable level of accuracy. PMID:25180204

  13. Novel insights into amylin aggregation

    PubMed Central

    Pillay, Karen; Govender, Patrick

    2014-01-01

    Amylin is a peptide that aggregates into species that are toxic to pancreatic beta cells, leading to type II diabetes. This study has for the first time quantified amylin association and dissociation kinetics (association constant (ka) = 28.7 ± 5.1 L mol−1 s−1 and dissociation constant (kd) = 2.8 ± 0.6 ×10−4 s−1) using surface plasmon resonance (SPR). Thus far, techniques used for the sizing of amylin aggregates do not cater for the real-time monitoring of unconstrained amylin in solution. In this regard we evaluated recently innovated nanoparticle tracking analysis (NTA). In addition, both SPR and NTA were used to study the effect of previously synthesized amylin derivatives on amylin aggregation and to evaluate their potential as a cell-free system for screening potential inhibitors of amylin-mediated cytotoxicity. Results obtained from NTA highlighted a predominance of 100–300 nm amylin aggregates and correlation to previously published cytotoxicity results suggests the toxic species of amylin to be 200–300 nm in size. The results seem to indicate that NTA has potential as a new technique to monitor the aggregation potential of amyloid peptides in solution and also to screen potential inhibitors of amylin-mediated cytotoxicity. PMID:26019498

  14. Equilibrium structure of ferrofluid aggregates

    SciTech Connect

    Yoon, Mina; Tomanek, David

    2010-01-01

    We study the equilibrium structure of large but finite aggregates of magnetic dipoles, representing a colloidal suspension of magnetite particles in a ferrofluid. With increasing system size, the structural motif evolves from chains and rings to multi-chain and multi-ring assemblies. Very large systems form single- and multi-wall coils, tubes and scrolls. These structural changes result from a competition between various energy terms, which can be approximated analytically within a continuum model. We also study the effect of external parameters such as magnetic field on the relative stability of these structures. Our results may give insight into experimental data obtained during solidification of ferrofluid aggregates at temperatures where thermal fluctuations become negligible in comparison to inter-particle interactions. These data may also help to experimentally control the aggregation of magnetic particles.

  15. Customer Aggregation: An Opportunity for Green Power?

    SciTech Connect

    Holt, E.; Bird, L.

    2001-02-26

    We undertook research into the experience of aggregation groups to determine whether customer aggregation offers an opportunity to bring green power choices to more customers. The objectives of this report, therefore, are to (1) identify the different types of aggregation that are occurring today, (2) learn whether aggregation offers an opportunity to advance sales of green power, and (3) share these concepts and approaches with potential aggregators and green power advocates.

  16. Fractal aggregates in tennis ball systems

    NASA Astrophysics Data System (ADS)

    Sabin, J.; Bandín, M.; Prieto, G.; Sarmiento, F.

    2009-09-01

    We present a new practical exercise to explain the mechanisms of aggregation of some colloids which are otherwise not easy to understand. We have used tennis balls to simulate, in a visual way, the aggregation of colloids under reaction-limited colloid aggregation (RLCA) and diffusion-limited colloid aggregation (DLCA) regimes. We have used the images of the cluster of balls, following Forrest and Witten's pioneering studies on the aggregation of smoke particles, to estimate their fractal dimension.

  17. Reducing Router Forwarding Table Size Using Aggregation and Caching

    ERIC Educational Resources Information Center

    Liu, Yaoqing

    2013-01-01

    The fast growth of global routing table size has been causing concerns that the Forwarding Information Base (FIB) will not be able to fit in existing routers' expensive line-card memory, and upgrades will lead to a higher cost for network operators and customers. FIB Aggregation, a technique that merges multiple FIB entries into one, is probably…

  18. 12 CFR 621.7 - Rule of aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Performance and Valuation Assessment § 621.7 Rule of aggregation. (a) When one loan to a borrower is placed in... related borrower are so financially interdependent with the borrower's operations that the economic survival of one will materially affect the economic survival of the other, determined in accordance...

  19. Effects of field variables on infield biomass bales aggregation strategies

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Infield aggregation of bales, an essential logistics operation of clearing the field for subsequent cropping, is influenced by several field variables, such as field shape, area, randomness on bale layout, biomass yield per unit area, bale row spacing, number of bales handled simultaneously, collect...

  20. 75 FR 32919 - Intent To Prepare an Environmental Impact Statement for Northwest Aggregates' Previously...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... Department of the Army; Corps of Engineers Intent To Prepare an Environmental Impact Statement for Northwest Aggregates' Previously Authorized Replacement of an Existing Barge Loading Facility in East Passage of Puget... mining operations at Northwest Aggregates' Maury Island facility. The Corps issued a permit to...

  1. Sugeno Fuzzy Integral as a Basis for the Interpretation of Flexible Queries Involving Monotonic Aggregates.

    ERIC Educational Resources Information Center

    Bosc, P.; Lietard, L.; Pivert, O.

    2003-01-01

    Considers flexible querying of relational databases. Highlights include SQL languages and basic aggregate operators; Sugeno's fuzzy integral; evaluation examples; and how and under what conditions other aggregate functions could be applied to fuzzy sets in a flexible query. (Author/LRW)

  2. Studies on recycled aggregates-based concrete.

    PubMed

    Rakshvir, Major; Barai, Sudhirkumar V

    2006-06-01

    Reduced extraction of raw materials, reduced transportation cost, improved profits, reduced environmental impact and fast-depleting reserves of conventional natural aggregates has necessitated the use of recycling, in order to be able to conserve conventional natural aggregate. In this study various physical and mechanical properties of recycled concrete aggregates were examined. Recycled concrete aggregates are different from natural aggregates and concrete made from them has specific properties. The percentages of recycled concrete aggregates were varied and it was observed that properties such as compressive strength showed a decrease of up to 10% as the percentage of recycled concrete aggregates increased. Water absorption of recycled aggregates was found to be greater than natural aggregates, and this needs to be compensated during mix design.

  3. RAGG - R EPISODIC AGGREGATION PACKAGE

    EPA Science Inventory

    The RAGG package is an R implementation of the CMAQ episodic model aggregation method developed by Constella Group and the Environmental Protection Agency. RAGG is a tool to provide climatological seasonal and annual deposition of sulphur and nitrogen for multimedia management. ...

  4. Cyclosporine A enhances platelet aggregation.

    PubMed

    Grace, A A; Barradas, M A; Mikhailidis, D P; Jeremy, J Y; Moorhead, J F; Sweny, P; Dandona, P

    1987-12-01

    In view of the reported increase in thromboembolic episodes following cyclosporine A (CyA) therapy, the effect of this drug on platelet aggregation and thromboxane A2 release was investigated. The addition of CyA, at therapeutic concentrations to platelet rich plasma from normal subjects in vitro was found to increase aggregation in response to adrenaline, collagen and ADP. Ingestion of CyA by healthy volunteers was also associated with enhanced platelet aggregation. The CyA-mediated enhancement of aggregation was further enhanced by the addition in vitro of therapeutic concentrations of heparin. Platelets from renal allograft recipients treated with CyA also showed hyperaggregability and increased thromboxane A2 release, which were most marked at "peak" plasma CyA concentration and less so at "trough" concentrations. Platelet hyperaggregability in renal allograft patients on long-term CyA therapy tended to revert towards normal following the replacement of CyA with azathioprine. Hypertensive patients with renal allografts on nifedipine therapy had normal platelet function and thromboxane release in spite of CyA therapy. These observations suggest that CyA-mediated platelet activation may contribute to the pathogenesis of the thromboembolic phenomena associated with the use of this drug. The increased release of thromboxane A2 (a vasoconstrictor) may also play a role in mediating CyA-related nephrotoxicity.

  5. Sequence-dependent Internalization of Aggregating Peptides*

    PubMed Central

    Couceiro, José R.; Gallardo, Rodrigo; De Smet, Frederik; De Baets, Greet; Baatsen, Pieter; Annaert, Wim; Roose, Kenny; Saelens, Xavier; Schymkowitz, Joost; Rousseau, Frederic

    2015-01-01

    Recently, a number of aggregation disease polypeptides have been shown to spread from cell to cell, thereby displaying prionoid behavior. Studying aggregate internalization, however, is often hampered by the complex kinetics of the aggregation process, resulting in the concomitant uptake of aggregates of different sizes by competing mechanisms, which makes it difficult to isolate pathway-specific responses to aggregates. We designed synthetic aggregating peptides bearing different aggregation propensities with the aim of producing modes of uptake that are sufficiently distinct to differentially analyze the cellular response to internalization. We found that small acidic aggregates (≤500 nm in diameter) were taken up by nonspecific endocytosis as part of the fluid phase and traveled through the endosomal compartment to lysosomes. By contrast, bigger basic aggregates (>1 μm) were taken up through a mechanism dependent on cytoskeletal reorganization and membrane remodeling with the morphological hallmarks of phagocytosis. Importantly, the properties of these aggregates determined not only the mechanism of internalization but also the involvement of the proteostatic machinery (the assembly of interconnected networks that control the biogenesis, folding, trafficking, and degradation of proteins) in the process; whereas the internalization of small acidic aggregates is HSF1-independent, the uptake of larger basic aggregates was HSF1-dependent, requiring Hsp70. Our results show that the biophysical properties of aggregates determine both their mechanism of internalization and proteostatic response. It remains to be seen whether these differences in cellular response contribute to the particular role of specific aggregated proteins in disease. PMID:25391649

  6. An Aggregation Advisor for Ligand Discovery.

    PubMed

    Irwin, John J; Duan, Da; Torosyan, Hayarpi; Doak, Allison K; Ziebart, Kristin T; Sterling, Teague; Tumanian, Gurgen; Shoichet, Brian K

    2015-09-10

    Colloidal aggregation of organic molecules is the dominant mechanism for artifactual inhibition of proteins, and controls against it are widely deployed. Notwithstanding an increasingly detailed understanding of this phenomenon, a method to reliably predict aggregation has remained elusive. Correspondingly, active molecules that act via aggregation continue to be found in early discovery campaigns and remain common in the literature. Over the past decade, over 12 thousand aggregating organic molecules have been identified, potentially enabling a precedent-based approach to match known aggregators with new molecules that may be expected to aggregate and lead to artifacts. We investigate an approach that uses lipophilicity, affinity, and similarity to known aggregators to advise on the likelihood that a candidate compound is an aggregator. In prospective experimental testing, five of seven new molecules with Tanimoto coefficients (Tc's) between 0.95 and 0.99 to known aggregators aggregated at relevant concentrations. Ten of 19 with Tc's between 0.94 and 0.90 and three of seven with Tc's between 0.89 and 0.85 also aggregated. Another three of the predicted compounds aggregated at higher concentrations. This method finds that 61 827 or 5.1% of the ligands acting in the 0.1 to 10 μM range in the medicinal chemistry literature are at least 85% similar to a known aggregator with these physical properties and may aggregate at relevant concentrations. Intriguingly, only 0.73% of all drug-like commercially available compounds resemble the known aggregators, suggesting that colloidal aggregators are enriched in the literature. As a percentage of the literature, aggregator-like compounds have increased 9-fold since 1995, partly reflecting the advent of high-throughput and virtual screens against molecular targets. Emerging from this study is an aggregator advisor database and tool ( http://advisor.bkslab.org ), free to the community, that may help distinguish between

  7. Nebular history of amoeboid olivine aggregates

    NASA Astrophysics Data System (ADS)

    Sugiura, N.; Petaev, M. I.; Kimura, M.; Miyazaki, A.; Hiyagon, H.

    2009-05-01

    Minor element (Ca, Cr, and Mn) concentrations in amoeboid olivine aggregates (AOAs) from primitive chondrites were measured and compared with those predicted by equilibrium condensation in the solar nebula. CaO concentrations in forsterite are low, particularly in porous aggregates. A plausible explanation appears that an equilibrium Ca activity was not maintained during the olivine condensation. CaO and MnO in forsterite are negatively correlated, with CaO being higher in compact aggregates. This suggests that the compact aggregates formed either by a prolonged reheating of the porous aggregates or by condensation and aggregation of forsterite during a very slow cooling in the nebula.

  8. The Future of Division I College Sports

    ERIC Educational Resources Information Center

    Likins, Peter

    2005-01-01

    When structured and operated as an integral part of the college or university, intercollegiate athletics can enhance the educational development of students and student-athletes and act as a window into the academy itself. And yet, there is an uneasy sense among chancellors and presidents that not all is right with college sports. There is rising…

  9. 33 CFR 117.555 - College Creek.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false College Creek. 117.555 Section 117.555 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.555 College Creek. The draws of...

  10. 33 CFR 117.555 - College Creek.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false College Creek. 117.555 Section 117.555 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.555 College Creek. The draws of...

  11. Community Colleges: Competing for Changing Clientele.

    ERIC Educational Resources Information Center

    Terry, John E.

    Population, economic, and technological changes will all affect the ways in which Canadian community colleges operate. The rise in the number of seniors, a slowing birth rate, and the aging of the "baby boomers" have influenced the demographics of college clientele. The dynamics of the global marketplace require a highly educated and skilled human…

  12. Entrepreneurship in the Community College: Revenue Diversification.

    ERIC Educational Resources Information Center

    Brightman, Richard W.

    1989-01-01

    Offers guidelines for community colleges wishing to become involved in for-profit ventures as a means of revenue diversification. Explains the differences between for-profit activities related to the college's non-profit mission and those that are not; alternative organizational structures; and common operations (e.g., catering, retail sales, and…

  13. A Checklist for Planning Community College Facilities.

    ERIC Educational Resources Information Center

    Merlo, Frank P.

    It is noted that in any planning process for community colleges, physical facilities are only an adjunct to the instructional program, and any types of facilities that evolve should be based on the nature of the students, the curriculum, and the general philosophy and operation of the college. A list is presented as a suggested guide for questions…

  14. How Private Colleges Survive Financial Crisis.

    ERIC Educational Resources Information Center

    Hamlin, Alan; Hungerford, Curtiss

    1989-01-01

    Private colleges that have prospered have done so by enhancing revenue, not by decreasing expenses. The private college president of today is becoming more a salesperson, delegating operational duties to subordinates while focusing on fund-raising and public-image concerns because of the chronic need for more money. (MLW)

  15. Community College Exemplary Instructional Programs, Volume III.

    ERIC Educational Resources Information Center

    Fideler, Elizabeth F., Ed.; Bazer, Gerald, Ed.

    Third in an annual series, this volume presents brief descriptions of a number of outstanding community college instructional programs identified by the National Council of Instructional Administrators (NCIA). Each description includes the address and telephone number of the college in which the program operates, and the names of the college…

  16. College Rankings: History, Criticism and Reform

    ERIC Educational Resources Information Center

    Myers, Luke; Robe, Jonathan

    2009-01-01

    Today, college quality rankings in news magazines and guidebooks are a big business with tangible impacts on the operation of higher education institutions. The college rankings published annually by "U.S. News and World Report" ("U.S. News") are so influential that Don Hossler of Indiana University derisively claims that higher education is the…

  17. An Economic Analysis of College Scholarship Policy.

    ERIC Educational Resources Information Center

    Owen, John D.

    A national scholarship policy based on a cost-benefit analysis of the social value of education is proposed as one method for improving current patterns of allocating US college scholarships and tuition funds. A central college subsidy agency, operating on a limited budget, would be required to allocate funds according to the maximum overall…

  18. Crisis Management in the Community College

    ERIC Educational Resources Information Center

    Murray, John P.; Kishur, Joseph M., Jr.

    2008-01-01

    This study examined the decision-making processes of community college presidents when confronted with unexpected and major challenges. During the day-to-day operations of community colleges, presidents typically rely on their best judgment when making routine decisions. However, this decision-making process needs to change when the unexpected…

  19. The PREP Program at Monterey Peninsula College.

    ERIC Educational Resources Information Center

    Bialek, Hilton M.

    This paper is an informal account of the establishment and operation of a U.S. Army Predischarge Education Program (PREP) in which Human Resources Research Organization (HumRRO) aided a junior college in providing high school graduates with significant preparation for college work. PREP is designed for servicemen and women soon to be discharged,…

  20. Role of streams in myxobacteria aggregate formation

    NASA Astrophysics Data System (ADS)

    Kiskowski, Maria A.; Jiang, Yi; Alber, Mark S.

    2004-10-01

    Cell contact, movement and directionality are important factors in biological development (morphogenesis), and myxobacteria are a model system for studying cell-cell interaction and cell organization preceding differentiation. When starved, thousands of myxobacteria cells align, stream and form aggregates which later develop into round, non-motile spores. Canonically, cell aggregation has been attributed to attractive chemotaxis, a long range interaction, but there is growing evidence that myxobacteria organization depends on contact-mediated cell-cell communication. We present a discrete stochastic model based on contact-mediated signaling that suggests an explanation for the initialization of early aggregates, aggregation dynamics and final aggregate distribution. Our model qualitatively reproduces the unique structures of myxobacteria aggregates and detailed stages which occur during myxobacteria aggregation: first, aggregates initialize in random positions and cells join aggregates by random walk; second, cells redistribute by moving within transient streams connecting aggregates. Streams play a critical role in final aggregate size distribution by redistributing cells among fewer, larger aggregates. The mechanism by which streams redistribute cells depends on aggregate sizes and is enhanced by noise. Our model predicts that with increased internal noise, more streams would form and streams would last longer. Simulation results suggest a series of new experiments.

  1. Iona College.

    ERIC Educational Resources Information Center

    Breslin, Richard D.

    1984-01-01

    The commitment of a small liberal arts college to academic and administrative computer use and to the computer literacy of its students is described and illustrated. Some of the potential problems are discussed, including faculty burnout, the institution-wide impact of program development, and additional planning needs. (MSE)

  2. College Valuations

    ERIC Educational Resources Information Center

    Rubin, Marc

    2015-01-01

    Using the data published by "Boston" magazine and the New England Board of Higher Education's "2016 Guide to New England Colleges & Universities," Marc Rubin examined higher education institutions (HEIs) prices, defined as tuition and plus fees, as a function of several independent factors including: (1) Percentage of…

  3. The Efficacy of Learning Communities at Two Community Colleges.

    ERIC Educational Resources Information Center

    Minkler, James E.

    This study examined learning communities at two community colleges, North Idaho College (NIC) and Spokane Falls Community College (SFCC) (Washington). Recent emphasis on learning outcomes and transforming the curriculum to be more learning centered has often come into direct conflict with operating under tight budget constraints. Learning…

  4. The Community College Theatre Department: An Administrative Point of Reference.

    ERIC Educational Resources Information Center

    Marine, Don

    This paper discusses aspects of faculty, administration, departmental structure, curriculum, and production operations of community college theatre departments in general and of Illinois Central College in particular. It contends that the common and revered tenet of community college institutional philosophy is "community service." The importance…

  5. Community Colleges and the Business of Workforce Development. Occasional Paper.

    ERIC Educational Resources Information Center

    Pindar, SaraLee

    This paper highlights New Jersey's community colleges and their efforts to respond to market and consumer needs. Since one-third of the average New Jersey community college operating budget is paid by credit and non-credit students and clients, the colleges must approach their business like private sector enterprises, performing market research…

  6. The College Store of the 1980's: Meeting the Challenge.

    ERIC Educational Resources Information Center

    Ball, Harold E.

    Approaches to help achieve a professional college store operation in the 1980s are outlined for the benefit of the college store staff member, supervisor, or manager, as well as administrators responsible for the review of the college store. The following areas are addressed: objectives of the service, organization, equipment and layout, the…

  7. Planning for the Future at San Joaquin Delta College.

    ERIC Educational Resources Information Center

    San Joaquin Delta Coll., Stockton, CA.

    This planning document provides data on current operations as of January 1994 and goals for the future at San Joaquin Delta College, in California. Section I, presents the context for planning at the college, describing the following major factors shaping the college's future: (1) the population is rapidly expanding; (2) fee increases and…

  8. Private School Graduation and College Attendance: Patterns of Transition. ASHE Annual Meeting 1981 Paper.

    ERIC Educational Resources Information Center

    Hammack, Floyd Morgan

    The college designations of over 5,800 recent graduates of 60 private secondary schools and the relationships between characteristics of these schools and the average selectivity of the colleges attended for each school were investigated. Aggregating all graduates, the data show considerable success in gaining admission to selective, prestigious…

  9. Influence of Subslab Aggregate Permeability of SSV Performance

    SciTech Connect

    Gadgil, A.J.; Bonnefous, Y.C.; Fisk, W.J.; Prill, R.J.; Nematollahi, A.

    1991-09-01

    The effectiveness of the technique of subslab ventilation (SSV) for limiting radon entry into basements was investigated through complementary experimentation and numerical modeling. Determination of the impact of subslab aggregate permeability on SSV performance was a primary objective. Subslab pressure fields resulting from SSV were measured in six well-characterized basements, each with a different combination of soil and aggregate permeability. The relationship between air velocity and pressure gradient within the three types of aggregate installed beneath the basement slabs was measured in the laboratory. A new numerical model of SSV was developed and verified with the field data. This model simulates non-Darcy flow in the aggregate. We demonstrate that non-Darcy effects significantly impact SSV performance. Field data and numerical simulations indicate that increasing the aggregate permeability within the investigated range of 2 x 10{sup -8} m{sup 2} to 3 x 10{sup -7} m{sup 2} substantially improves the extension of the subslab pressure field due to SSV operation. Subslab pressure field extension also improves as soil permeability decreases between 10{sup -9} m{sup 2} and 10{sup -10} m{sup 2}. With a slab-wall gap thickness of 1 mm and the range of aggregate permeability investigated, further reductions in soil permeability do not significantly improve the subslab pressure field extension. Sealing of cracks in the slab and excavation of a small pit where the SSV pipe penetrates the slab also dramatically improve this pressure field extension. A large ratio of aggregate permeability to soil permeability reduces the need for large depressurizations at the SSV pit. Our findings are consistent with the results of prior field studies; however, our understanding of SSV is improved and the dependence of SSV performance on the relevant parameters can now be quantified with the model.

  10. Protein aggregation in salt solutions

    PubMed Central

    Kastelic, Miha; Kalyuzhnyi, Yurij V.; Hribar-Lee, Barbara; Dill, Ken A.; Vlachy, Vojko

    2015-01-01

    Protein aggregation is broadly important in diseases and in formulations of biological drugs. Here, we develop a theoretical model for reversible protein–protein aggregation in salt solutions. We treat proteins as hard spheres having square-well-energy binding sites, using Wertheim’s thermodynamic perturbation theory. The necessary condition required for such modeling to be realistic is that proteins in solution during the experiment remain in their compact form. Within this limitation our model gives accurate liquid–liquid coexistence curves for lysozyme and γ IIIa-crystallin solutions in respective buffers. It provides good fits to the cloud-point curves of lysozyme in buffer–salt mixtures as a function of the type and concentration of salt. It than predicts full coexistence curves, osmotic compressibilities, and second virial coefficients under such conditions. This treatment may also be relevant to protein crystallization. PMID:25964322

  11. Protein aggregation in salt solutions.

    PubMed

    Kastelic, Miha; Kalyuzhnyi, Yurij V; Hribar-Lee, Barbara; Dill, Ken A; Vlachy, Vojko

    2015-05-26

    Protein aggregation is broadly important in diseases and in formulations of biological drugs. Here, we develop a theoretical model for reversible protein-protein aggregation in salt solutions. We treat proteins as hard spheres having square-well-energy binding sites, using Wertheim's thermodynamic perturbation theory. The necessary condition required for such modeling to be realistic is that proteins in solution during the experiment remain in their compact form. Within this limitation our model gives accurate liquid-liquid coexistence curves for lysozyme and γ IIIa-crystallin solutions in respective buffers. It provides good fits to the cloud-point curves of lysozyme in buffer-salt mixtures as a function of the type and concentration of salt. It than predicts full coexistence curves, osmotic compressibilities, and second virial coefficients under such conditions. This treatment may also be relevant to protein crystallization.

  12. Aggregation of Heterogeneously Charged Colloids.

    PubMed

    Dempster, Joshua M; Olvera de la Cruz, Monica

    2016-06-28

    Patchy colloids are attractive as programmable building blocks for metamaterials. Inverse patchy colloids, in which a charged surface is decorated with patches of the opposite charge, are additionally noteworthy as models for heterogeneously charged biological materials such as proteins. We study the phases and aggregation behavior of a single charged patch in an oppositely charged colloid with a single-site model. This single-patch inverse patchy colloid model shows a large number of phases when varying patch size. For large patch sizes we find ferroelectric crystals, while small patch sizes produce cross-linked gels. Intermediate values produce monodisperse clusters and unusual worm structures that preserve finite ratios of area to volume. The polarization observed at large patch sizes is robust under extreme disorder in patch size and shape. We examine phase-temperature dependence and coexistence curves and find that large patch sizes produce polarized liquids, in contrast to mean-field predictions. Finally, we introduce small numbers of unpatched charged colloids. These can either suppress or encourage aggregation depending on their concentration and the size of the patches on the patched colloids. These effects can be exploited to control aggregation and to measure effective patch size.

  13. Tau Phosphorylation, Aggregation, and Cell Toxicity

    PubMed Central

    Avila, J.; Santa-María, I.; Pérez, M.; Hernández, F.; Moreno, F.

    2006-01-01

    Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies. PMID:17047313

  14. Mineral resource of the month: aggregates

    USGS Publications Warehouse

    Willett, Jason C.

    2012-01-01

    Crushed stone and construction sand and gravel, the two major types of natural aggregates, are among the most abundant and accessible natural resources on the planet. The earliest civilizations used aggregates for various purposes, mainly construction. Today aggregates provide the basic raw materials for the foundation of modern society.

  15. Testing College-Level Critical Thinking.

    ERIC Educational Resources Information Center

    Facione, Peter A.

    1986-01-01

    At the college level, the obstacles to machine-testing of critical thinking are more pedagogical and practical than theoretical and include creating an operational definition, differentiating critical thinking skills and subskills, and establishing test reliability and validity. (MSE)

  16. 33 CFR 117.555 - College Creek.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.555 College Creek. The draws of the Naval Academy highway bridge, mile 0.3 at Annapolis, and the Maryland highway bridge, mile 0.4...

  17. 33 CFR 117.555 - College Creek.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.555 College Creek. The draws of the Naval Academy highway bridge, mile 0.3 at Annapolis, and the Maryland highway bridge, mile 0.4...

  18. 33 CFR 117.555 - College Creek.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.555 College Creek. The draws of the Naval Academy highway bridge, mile 0.3 at Annapolis, and the Maryland highway bridge, mile 0.4...

  19. The Community College Option

    ERIC Educational Resources Information Center

    Rosenbaum, James E.; Ahearn, Caitlin; Rosenbaum, Janet

    2016-01-01

    Efforts to promote college for all for all has opened college doors to a broad range of students. But college--and career success after college--doesn't have to mean a bachelor's degree. Community college credentials, such as associate's degrees and one-year certificates, can lead to further degrees or jobs that offer more benefits than students…

  20. 1890 Land-Grant Colleges Facilities. Hearing Before the Subcommittee on Department Operations, Research, and Foreign Agriculture of the Committee on Agriculture, House of Representatives, Ninety-Seventh Congress, First Session on H.R. 1309.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Agriculture.

    The Committee on Agriculture hearing in the U.S. House of Representatives on H.R. 1309, which pertains to land-grant colleges and research facilities, including the text of the bill and witness statements, are presented. The bill would provide grants to the 1890 land-grant colleges, including Tuskegee Institute, for the purpose of assisting these…

  1. Where Do Community Colleges Stand?

    ERIC Educational Resources Information Center

    Pietak, Raymond

    1971-01-01

    Traditional clubs and structures continue to serve needs of interested students. However, more socially aware students must have operational vehicles to meet their dynamic needs. The identification of problem areas and the creation of ad hoc interest groups should be added to the college activity programs. (Author)

  2. College and University Apartment Housing.

    ERIC Educational Resources Information Center

    Casey-Powell, Deborah, Ed.

    The purpose of this book is to update housing professionals on the current issues and future trends facing college and university apartment operations in the 21st century. Its chapters are: (1) "The History of Apartment Housing" (Rena Buchan); (2) "Research in Apartment Housing" (Donald Whalen); (3) "Community Services and Programming: A Search…

  3. The Influence of Leadership Development Programs on the Community College Leadership Shortage: A Case Study

    ERIC Educational Resources Information Center

    Bornheimer, Mary E.

    2010-01-01

    Community colleges are experiencing a leadership shortage due to the majority of college presidents retiring by 2011. This leadership shortage has created financial and operational challenges for the nation's community college system. To remedy the shortage, community colleges and other organizations have developed leadership development programs.…

  4. Reachout: Associations of College Unions-International Proceedings of the Forty Eighth Annual Conference.

    ERIC Educational Resources Information Center

    Association of Coll. Unions-International, Madison, WI.

    A wide range of articles concerned with the major work and interests of college unions are organized into six topical areas; (1) philosophical considerations about the purposes and directions of college unions; (2) management and operation of the college union; (3) food service; (4) programming; (5) contemporary society and the college union; and…

  5. The Chicago City-Wide Institute of the City Colleges of Chicago.

    ERIC Educational Resources Information Center

    Chicago City Colleges, IL. Chicago City-Wide Inst.

    This document describes the Chicago City-Wide Institute, a non-campus college established in 1974 as the ninth administrative unit of the City Colleges of Chicago. The basic mission of the Institute is to develop and operate programs at the college level for adults who cannot or choose not to go to a traditional college campus. The Institute also…

  6. A GIS analysis of suitability for construction aggregate recycling sites using regional transportation network and population density features

    USGS Publications Warehouse

    Robinson, G.R.; Kapo, K.E.

    2004-01-01

    Aggregate is used in road and building construction to provide bulk, strength, support, and wear resistance. Reclaimed asphalt pavement (RAP) and reclaimed Portland cement concrete (RPCC) are abundant and available sources of recycled aggregate. In this paper, current aggregate production operations in Virginia, Maryland, and the District of Columbia are used to develop spatial association models for the recycled aggregate industry with regional transportation network and population density features. The cost of construction aggregate to the end user is strongly influenced by the cost of transporting processed aggregate from the production site to the construction site. More than 60% of operations recycling aggregate in the mid-Atlantic study area are located within 4.8 km (3 miles) of an interstate highway. Transportation corridors provide both sites of likely road construction where aggregate is used and an efficient means to move both materials and on-site processing equipment back and forth from various work sites to the recycling operations. Urban and developing areas provide a high market demand for aggregate and a ready source of construction debris that may be processed into recycled aggregate. Most aggregate recycling operators in the study area are sited in counties with population densities exceeding 77 people/km2 (200 people/mile 2). No aggregate recycling operations are sited in counties with less than 19 people/km2 (50 people/mile2), reflecting the lack of sufficient long-term sources of construction debris to be used as an aggregate source, as well as the lack of a sufficient market demand for aggregate in most rural areas to locate a recycling operation there or justify the required investment in the equipment to process and produce recycled aggregate. Weights of evidence analyses (WofE), measuring correlation on an area-normalized basis, and weighted logistic regression (WLR), are used to model the distribution of RAP and RPCC operations relative

  7. Microwave extinction characteristics of nanoparticle aggregates

    NASA Astrophysics Data System (ADS)

    Wu, Y. P.; Cheng, J. X.; Liu, X. X.; Wang, H. X.; Zhao, F. T.; Wen, W. W.

    2016-07-01

    Structure of nanoparticle aggregates plays an important role in microwave extinction capacity. The diffusion-limited aggregation model (DLA) for fractal growth is utilized to explore the possible structures of nanoparticle aggregates by computer simulation. Based on the discrete dipole approximation (DDA) method, the microwave extinction performance by different nano-carborundum aggregates is numerically analyzed. The effects of the particle quantity, original diameter, fractal structure, as well as orientation on microwave extinction are investigated, and also the extinction characteristics of aggregates are compared with the spherical nanoparticle in the same volume. Numerical results give out that proper aggregation of nanoparticle is beneficial to microwave extinction capacity, and the microwave extinction cross section by aggregated granules is better than that of the spherical solid one in the same volume.

  8. What favors convective aggregation and why?

    NASA Astrophysics Data System (ADS)

    Muller, Caroline; Bony, Sandrine

    2015-07-01

    The organization of convection is ubiquitous, but its physical understanding remains limited. One particular type of organization is the spatial self-aggregation of convection, taking the form of cloud clusters, or tropical cyclones in the presence of rotation. We show that several physical processes can give rise to self-aggregation and highlight the key features responsible for it, using idealized simulations. Longwave radiative feedbacks yield a "radiative aggregation." In that case, sufficient spatial variability of radiative cooling rates yields a low-level circulation, which induces the upgradient energy transport and radiative-convective instability. Not only do vertically integrated radiative budgets matter but the vertical profile of cooling is also crucial. Convective aggregation is facilitated when downdrafts below clouds are weak ("moisture-memory aggregation"), and this is sufficient to trigger aggregation in the absence of longwave radiative feedbacks. These results shed some light on the sensitivity of self-aggregation to various parameters, including resolution or domain size.

  9. Simulation of J-aggregate microcavity photoluminescence

    NASA Astrophysics Data System (ADS)

    Michetti, Paolo; La Rocca, Giuseppe C.

    2008-05-01

    We have developed a model in order to account for the photoexcitation dynamics of J-aggregate films and strongly coupled J-aggregate microcavities. The J aggregates are described as a disordered Frenkel exciton system in which relaxation occurs due to the presence of a thermal bath of molecular vibrations. The correspondence between the photophysics in J-aggregate films and that in J-aggregate microcavities is obtained by introducing a model polariton wave function mixing cavity photon modes and J-aggregate super-radiant excitons. With the same description of the material properties, we have calculated both absorption and luminescence spectra for the J-aggregate film and the photoluminescence of strongly coupled organic microcavities. The model is able to account for the fast relaxation dynamics in organic microcavities following nonresonant pumping and explains the temperature dependence of the ratio between the upper polariton and the lower polariton luminescence.

  10. Changes in fractal dimension during aggregation.

    PubMed

    Chakraborti, Rajat K; Gardner, Kevin H; Atkinson, Joseph F; Van Benschoten, John E

    2003-02-01

    Experiments were performed to evaluate temporal changes in the fractal dimension of aggregates formed during flocculation of an initially monodisperse suspension of latex microspheres. Particle size distributions and aggregate geometrical information at different mixing times were obtained using a non-intrusive optical sampling and digital image analysis technique, under variable conditions of mixing speed, coagulant (alum) dose and particle concentration. Pixel resolution required to determine aggregate size and geometric measures including the fractal dimension is discussed and a quantitative measure of accuracy is developed. The two-dimensional fractal dimension was found to range from 1.94 to 1.48, corresponding to aggregates that are either relatively compact or loosely structured, respectively. Changes in fractal dimension are explained using a conceptual model, which describes changes in fractal dimension associated with aggregate growth and changes in aggregate structure. For aggregation of an initially monodisperse suspension, the fractal dimension was found to decrease over time in the initial stages of floc formation.

  11. COMMERCIAL DEMONSTRATION OF THE MANUFACTURED AGGREGATE PROCESSING TECHNOLOGY UTILIZING SPRAY DRYER ASH

    SciTech Connect

    Roy Scandrol

    2003-04-01

    Universal Aggregates, LLC proposes to design, construct and operate a lightweight aggregate manufacturing plant at the Birchwood Power Facility in King George, Virginia. The installation and start-up expenses for the Birchwood Aggregate Facility are $19.5 million. The DOE share is $7.2 million (37%) and the Universal Aggregates share is $12.3 (63%). The project team consists of CONSOL Energy Inc., P.J. Dick, Inc., SynAggs, LLC, and Universal Aggregates, LLC. The Birchwood Facility will transform 115,000 tons per year of spray dryer by-products that are currently being disposed of in an offsite landfill into 167,000 tons of a useful product, lightweight aggregates that can be used to manufacture lightweight aggregates that can be used to manufacture lightweight and medium weight masonry blocks. In addition to the environmental benefits, the Birchwood Facility will create eight (8) manufacturing jobs plus additional employment in the local trucking industry to deliver the aggregate to customers or reagents to the facility. A successful demonstration would lead to additional lightweight aggregate manufacturing facilities in the United States. There are currently twenty-one (21) spray dryer facilities operating in the United States that produce an adequate amount of spray dryer by-product to economically justify the installation of a lightweight aggregate manufacturing facility. Industry sources believe that as additional scrubbing is required, dry flue gas desulfurization (FGD) technologies will be the technology of choice. Letters from potential lightweight aggregate customers indicate that there is a market for the product once the commercialization barriers are eliminated by this demonstration project.

  12. COMMERCIAL DEMONSTRATION OF THE MANUFACTURED AGGREGATE PROCESSING TECHNOLOGY UTILIZING SPRAY DRYER ASH

    SciTech Connect

    Roy Scandrol

    2003-10-01

    Universal Aggregates, LLC proposes to design, construct and operate a lightweight aggregate manufacturing plant at the Birchwood Power Facility in King George, Virginia. The installation and start-up expenses for the Birchwood Aggregate Facility are $19.5 million. The DOE share is $7.2 million (37%) and the Universal Aggregates share is $12.3 (63%). The project team consists of CONSOL Energy Inc., P.J. Dick, Inc., SynAggs, LLC, and Universal Aggregates, LLC. The Birchwood Facility will transform 115,000 tons per year of spray dryer by-products that are currently being disposed of in an offsite landfill into 167,000 tons of a useful product, lightweight aggregates that can be used to manufacture lightweight aggregates that can be used to manufacture lightweight and medium weight masonry blocks. In addition to the environmental benefits, the Birchwood Facility will create nine (9) manufacturing jobs plus additional employment in the local trucking industry to deliver the aggregate to customers or reagents to the facility. A successful demonstration would lead to additional lightweight aggregate manufacturing facilities in the United States. There are currently twenty-one (21) spray dryer facilities operating in the United States that produce an adequate amount of spray dryer by-product to economically justify the installation of a lightweight aggregate manufacturing facility. Industry sources believe that as additional scrubbing is required, dry FGD technologies will be the technology of choice. Letters from potential lightweight aggregate customers indicate that there is a market for the product once the commercialization barriers are eliminated by this demonstration project.

  13. Report on Enrollment, Fall 1985. California Community Colleges.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Office of the Chancellor.

    Drawing from the Student File of the Chancellor's Office Information System, this report profiles the demographic and academic characteristics of nearly 1.2 million actively enrolled students in the California community colleges during fall 1985. The report is divided into three sections of tables. Section I aggregates student counts and…

  14. Origin of Enrollments, Accredited Colleges and Universities, Fall Semester, 1972.

    ERIC Educational Resources Information Center

    Kentucky Council on Public Higher Education, Frankfort.

    This document is a delineation of student enrollments for the fall semester 1972 from the 42 accredited Kentucky colleges and universities. The enrollments are aggregated by institution, state, foreign country, and Kentucky resident students by county of origin. A few general findings related to the overall enrollment characteristics of the…

  15. An Investigation of Nonverbal Cue Combinations and the Validity of Aggregation Measurement Techniques in a Spontaneous Persuasive Interaction.

    ERIC Educational Resources Information Center

    Buller, David B.

    A study was conducted to examine the presence and composition of nonverbal cues exhibited in a spontaneous dyadic interaction and to investigate the assumption that cue variation is inconsequential to the effect of nonverbal behavior implicit in methods that aggregate cue incidence across interactions. Subjects, 110 college undergraduates, worked…

  16. College Students with ADHD

    MedlinePlus

    ... Families Guide Skip breadcrumb navigation College Students with ADHD Quick Links Facts For Families Guide Facts For ... No. 111; Updated December 2013 Many students with Attention Deficit Hyperactivity Disorder (ADHD) attend college. College students with ADHD face ...

  17. Specification aggregate quarry expansion: a case study demonstrating sustainable management of natural aggregate resources

    USGS Publications Warehouse

    Langer, William H.; Tucker, M.L.

    2003-01-01

    Many countries, provinces, territories, or states in the European Union, Australia, Canada, the United States, and elsewhere have begun implementing sustainability programs, but most of those programs stop short of sustainable management of aggregate resources. Sustainable practices do not always have to be conducted under the title of sustainability. This case study describes how Lafarge, a large multinational construction materials supplier, implemented the principles of sustainability even though there was an absence of existing local government policies or procedures addressing sustainable resource management. Jefferson County, Colorado, USA, is one of three counties in the six-county Denver, Colorado, region that has potentially available sources of crushed stone. Crushed stone comprises 30 percent of the aggregate produced in the area and plays a major role in regional aggregate resource needs. Jefferson County is home to four of the five crushed stone operations in the Denver region. Lafarge operates one of those four quarries. Lafarge recently proposed to expand its reserves by exchanging company-owned land for existing dedicated open space land adjacent to their quarry but owned by Jefferson County. A similar proposal submitted about 10 years earlier had been denied. Contrary to the earlier proposal, which was predicated on public relations, the new proposal was predicated on public trust. Although not explicitly managed under the moniker of sustainability, Lafarge used basic management principles that embody the tenets of sustainability. To achieve the goals of sustainable aggregate management where no governmental policies existed, Lafarge not only assumed their role of being a responsible corporate and environmental member of the community, but also assumed the role of facilitator to encourage and enable other stakeholders to responsibly resolve legitimate concerns regarding the Lafarge quarry proposal. Lafarge successfully presented an enlightened

  18. Inhomogeneous diffusion-limited aggregation

    NASA Technical Reports Server (NTRS)

    Selinger, Robin Blumberg; Nittmann, Johann; Stanley, H. E.

    1989-01-01

    It is demonstrated here that inhomogeneous diffusion-limited aggregation (DLA) model can be used to simulate viscous fingering in a medium with inhomogeneous permeability and homogeneous porosity. The medium consists of a pipe-pore square-lattice network in which all pores have equal volume and the pipes have negligible volume. It is shown that fluctuations in a DLA-based growth process may be tuned by noise reduction, and that fluctuations in the velocity of the moving interface are multiplicative in form.

  19. Familial Aggregation of Absolute Pitch

    PubMed Central

    Baharloo, Siamak; Service, Susan K.; Risch, Neil; Gitschier, Jane; Freimer, Nelson B.

    2000-01-01

    Absolute pitch (AP) is a behavioral trait that is defined as the ability to identify the pitch of tones in the absence of a reference pitch. AP is an ideal phenotype for investigation of gene and environment interactions in the development of complex human behaviors. Individuals who score exceptionally well on formalized auditory tests of pitch perception are designated as “AP-1.” As described in this report, auditory testing of siblings of AP-1 probands and of a control sample indicates that AP-1 aggregates in families. The implications of this finding for the mapping of loci for AP-1 predisposition are discussed. PMID:10924408

  20. Leadership Qualities Desired for College Presidents as Perceived by College Trustees

    ERIC Educational Resources Information Center

    Para, Diane J.

    2010-01-01

    The purpose of this study was to identify presidential leadership styles and behaviors that selected college trustee chairs (private institutions) and college council chairs (state-operated institutions) perceived to be most relevant and important for presidential effectiveness and success in leading higher education institutions. Second, it was…

  1. Detergent-mediated protein aggregation.

    PubMed

    Neale, Chris; Ghanei, Hamed; Holyoake, John; Bishop, Russell E; Privé, Gilbert G; Pomès, Régis

    2013-04-01

    Because detergents are commonly used to solvate membrane proteins for structural evaluation, much attention has been devoted to assessing the conformational bias imparted by detergent micelles in comparison to the native environment of the lipid bilayer. Here, we conduct six 500-ns simulations of a system with >600,000 atoms to investigate the spontaneous self assembly of dodecylphosphocholine detergent around multiple molecules of the integral membrane protein PagP. This detergent formed equatorial micelles in which acyl chains surround the protein's hydrophobic belt, confirming existing models of the detergent solvation of membrane proteins. In addition, unexpectedly, the extracellular and periplasmic apical surfaces of PagP interacted with the headgroups of detergents in other micelles 85 and 60% of the time, respectively, forming complexes that were stable for hundreds of nanoseconds. In some cases, an apical surface of one molecule of PagP interacted with an equatorial micelle surrounding another molecule of PagP. In other cases, the apical surfaces of two molecules of PagP simultaneously bound a neat detergent micelle. In these ways, detergents mediated the non-specific aggregation of folded PagP. These simulation results are consistent with dynamic light scattering experiments, which show that, at detergent concentrations ≥600 mM, PagP induces the formation of large scattering species that are likely to contain many copies of the PagP protein. Together, these simulation and experimental results point to a potentially generic mechanism of detergent-mediated protein aggregation.

  2. Attracted diffusion-limited aggregation.

    PubMed

    Rahbari, S H Ebrahimnazhad; Saberi, A A

    2012-07-01

    In this paper we present results of extensive Monte Carlo simulations of diffusion-limited aggregation (DLA) with a seed placed on an attractive plane as a simple model in connection with the electrical double layers. We compute the fractal dimension of the aggregated patterns as a function of the attraction strength α. For the patterns grown in both two and three dimensions, the fractal dimension shows a significant dependence on the attraction strength for small values of α and approaches that of the ordinary two-dimensional (2D) DLA in the limit of large α. For the nonattracting case with α = 1, our results in three dimensions reproduce the patterns of 3D ordinary DLA, while in two dimensions our model leads to the formation of a compact cluster with dimension 2. For intermediate α, the 3D clusters have a quasi-2D structure with a fractal dimension very close to that of the ordinary 2D DLA. This allows one to control the morphology of a growing cluster by tuning a single external parameter α. PMID:23005417

  3. Attracted diffusion-limited aggregation

    NASA Astrophysics Data System (ADS)

    Rahbari, S. H. Ebrahimnazhad; Saberi, A. A.

    2012-07-01

    In this paper we present results of extensive Monte Carlo simulations of diffusion-limited aggregation (DLA) with a seed placed on an attractive plane as a simple model in connection with the electrical double layers. We compute the fractal dimension of the aggregated patterns as a function of the attraction strength α. For the patterns grown in both two and three dimensions, the fractal dimension shows a significant dependence on the attraction strength for small values of α and approaches that of the ordinary two-dimensional (2D) DLA in the limit of large α. For the nonattracting case with α=1, our results in three dimensions reproduce the patterns of 3D ordinary DLA, while in two dimensions our model leads to the formation of a compact cluster with dimension 2. For intermediate α, the 3D clusters have a quasi-2D structure with a fractal dimension very close to that of the ordinary 2D DLA. This allows one to control the morphology of a growing cluster by tuning a single external parameter α.

  4. Sectoral shifts and aggregate unemployment

    SciTech Connect

    Loungani, P.

    1986-01-01

    Some recent research has taken the view that sectoral or industry-specific shocks significantly affect aggregate unemployment by increasing the amount of inter-industry labor reallocation required. The empirical evidence for this view rests on the finding that during the 1950s - and again during the 1970s - there was a positive correlation between aggregate unemployment and the dispersion of employment growth rates. This thesis demonstrates that this correlation arises largely because oil price shocks affect both unemployment and the dispersion of employment growth. Once the dispersion due to oil shocks is accounted for, the residual dispersion in employment has very low explanatory power for unemployment. Since the dispersion index does not measure pure sectoral shifts, an alternate measure of dispersion is developed that serves as a better proxy for the amount of inter-industry labor reallocation required each period. Estimates using this measure suggest that, during the 1950s, temporary increases in the relative price of oil were responsible for generating the observed correlation. On the other hand, sectoral shifts were important during the 1970s; in particular, the 1973 oil price increase has had significant reallocative effects on the economy. This contention is subjected to further tests by looking at the time-series behavior of employment in durable-goods industries and also by following the inter-industry movements of workers over time through the use of panel data.

  5. A review of volcanic ash aggregation

    NASA Astrophysics Data System (ADS)

    Brown, R. J.; Bonadonna, C.; Durant, A. J.

    2012-01-01

    Most volcanic ash particles with diameters <63 μm settle from eruption clouds as particle aggregates that cumulatively have larger sizes, lower densities, and higher terminal fall velocities than individual constituent particles. Particle aggregation reduces the atmospheric residence time of fine ash, which results in a proportional increase in fine ash fallout within 10-100 s km from the volcano and a reduction in airborne fine ash mass concentrations 1000 s km from the volcano. Aggregate characteristics vary with distance from the volcano: proximal aggregates are typically larger (up to cm size) with concentric structures, while distal aggregates are typically smaller (sub-millimetre size). Particles comprising ash aggregates are bound through hydro-bonds (liquid and ice water) and electrostatic forces, and the rate of particle aggregation correlates with cloud liquid water availability. Eruption source parameters (including initial particle size distribution, erupted mass, eruption column height, cloud water content and temperature) and the eruption plume temperature lapse rate, coupled with the environmental parameters, determines the type and spatiotemporal distribution of aggregates. Field studies, lab experiments and modelling investigations have already provided important insights on the process of particle aggregation. However, new integrated observations that combine remote sensing studies of ash clouds with field measurement and sampling, and lab experiments are required to fill current gaps in knowledge surrounding the theory of ash aggregate formation.

  6. Role of Multicellular Aggregates in Biofilm Formation

    PubMed Central

    Kragh, Kasper N.; Hutchison, Jaime B.; Melaugh, Gavin; Rodesney, Chris; Roberts, Aled E. L.; Irie, Yasuhiko; Jensen, Peter Ø.; Diggle, Stephen P.; Allen, Rosalind J.

    2016-01-01

    ABSTRACT In traditional models of in vitro biofilm development, individual bacterial cells seed a surface, multiply, and mature into multicellular, three-dimensional structures. Much research has been devoted to elucidating the mechanisms governing the initial attachment of single cells to surfaces. However, in natural environments and during infection, bacterial cells tend to clump as multicellular aggregates, and biofilms can also slough off aggregates as a part of the dispersal process. This makes it likely that biofilms are often seeded by aggregates and single cells, yet how these aggregates impact biofilm initiation and development is not known. Here we use a combination of experimental and computational approaches to determine the relative fitness of single cells and preformed aggregates during early development of Pseudomonas aeruginosa biofilms. We find that the relative fitness of aggregates depends markedly on the density of surrounding single cells, i.e., the level of competition for growth resources. When competition between aggregates and single cells is low, an aggregate has a growth disadvantage because the aggregate interior has poor access to growth resources. However, if competition is high, aggregates exhibit higher fitness, because extending vertically above the surface gives cells at the top of aggregates better access to growth resources. Other advantages of seeding by aggregates, such as earlier switching to a biofilm-like phenotype and enhanced resilience toward antibiotics and immune response, may add to this ecological benefit. Our findings suggest that current models of biofilm formation should be reconsidered to incorporate the role of aggregates in biofilm initiation. PMID:27006463

  7. Asphaltene Aggregation and Fouling Behavior

    NASA Astrophysics Data System (ADS)

    Derakhshesh, Marzie

    This thesis explored the properties of asphaltene nano-aggregates in crude oil and toluene based solutions and fouling at process furnace temperatures, and the links between these two phenomena. The link between stability of asphaltenes at ambient conditions and fouling at the conditions of a delayed coker furnace, at over 450 °C, was examined by blending crude oil with an aliphatic diluent in different ratios. The stability of the blends were measured using a S-value analyzer, then fouling rates were measured on electrically heated stainless steel 316 wires in an autoclave reactor. The less stable the blend, the greater the rate and extent of fouling. The most severe fouling occurred with the unstable asphaltenes. SEM imaging of the foulant illustrates very different textures, with the structure becoming more porous with lower stability. Under cross-polarized light, the coke shows the presence of mesophase in the foulant layer. These data suggest a correlation between the fouling rate at high temperature furnace conditions and the stability index of the crude oil. Three organic polysulfides were introduced to the crude oil to examine their effect on fouling. The polysulfides are able to reduce coking and carbon monoxide generation in steam crackers. The fouling results demonstrated that polysulfide with more sulfur content increased the amount of corrosion-fouling of the wire. Various additives, solvents, ultrasound, and heat were employed to attempt to completely disaggregate the asphaltene nano-aggregates in solution at room temperature. The primary analytical technique used to monitor the nano-aggregation state of the asphaltenes in solution was the UV-visible spectroscopy. The results indicate that stronger solvents, such as pyridine and quinoline, combined with ionic liquids yield a slight reduction in the apparent absorbance at longer wavelengths, indicative of a decrease in the nano-aggregate size although the magnitude of the decrease is not significant

  8. Natural aggregates of the conterminous United States

    USGS Publications Warehouse

    Langer, William H.

    1988-01-01

    Crushed stone and sand and gravel are the two main sources of natural aggregates. These materials are commonly used construction materials and frequently can be interchanged with one another. They are widely used throughout the United States, with every State except two producing crushed stone. Together they amount to about half the mining volume in the United States. Approximately 96 percent of sand and gravel and 77 percent of the crushed stone produced in the United States are used in the construction industry. Natural aggregates are widely distributed throughout the United States in a variety of geologic environments. Sand and gravel deposits commonly are the results of the weathering of bedrock and subsequent transportation and deposition of the material by water or ice (glaciers). As such, they commonly occur as river or stream deposits or in glaciated areas as glaciofluvial and other deposits. Crushed stone aggregates are derived from a wide variety of parent bedrock materials. Limestone and other carbonates account for approximately three quarters of the rocks used for crushed stone, with granite and other igneous rocks making up the bulk of the remainder. Limestone deposits are widespread throughout the Central and Eastern United States and are scattered in the West. Granites are widely distributed in the Eastern and Western United States, with few exposures in the Midwest. Igneous rocks (excluding granites) are largely concentrated in the Western United States and in a few isolated localities in the East. Even though natural aggregates are widely distributed throughout the United States, they are not universally available for consumptive use. Some areas are devoid of sand and gravel, and potential sources of crushed stone may be covered with sufficient unconsolidated material to make surface mining impractical. In some areas many aggregates do not meet the physical property requirements for certain uses, or they may contain mineral constituents that react

  9. [Heat generation, accumulation and dissipation in clusters of the aggregated insects].

    PubMed

    Es'kov, E K; Toboev, V A

    2009-01-01

    , which connects heat production qg, heat dissipation q(s), and heat content of body change deltaq. At the optimum temperatures range, the aggregate insects tend to retain the relation between q(t) and q(s) at which deltaq = const. Therefore, heat production and heat dissipation in relation to the body heat content play the role of the control action. One can trace more or less expressed convergent similarity in the cold adaptation complex between the bees and the homoiotherms. But the temperature regulation by the aggregate bees does not connected to the presence of the thermoregulation center (setting point) in their aggregate. Aggregate bees operate as simple independent subjects with a low number of effective degrees of freedom. The absence of the setting point (similar to the mammalian hypothalamus) excludes a possibility of integration of the temperature information from different parts of the bees aggregate. Their interaction is provided by the principle of decentralized control in accordance to which numerous subsystems (individual specimens) composing the aggregate operate using only limited local information obtained by their thermoreceptors. As far as only bees localized at the aggregate periphery (especially those that are localized at its lower part) are subjected to cooling, they feel adverse thermal effect to most extent. Therefore, thermal receptors of the bees accidentally appeared in this zone feel largest excitation, and this apparently stimulate their migration inside of the aggregate. These bees penetrate inside of the aggregate and influence by their cold on the specimens contacting with them, which obtain information about decrease of the ambient temperature. In this respect the most cooled part of the bees serve in aggregate as "dynamic cold receptor" and "coolant".

  10. Waves and aggregation patterns in myxobacteria

    NASA Astrophysics Data System (ADS)

    Igoshin, Oleg A.; Welch, Roy; Kaiser, Dale; Oster, George

    2004-03-01

    Under starvation conditions, a population of myxobacteria aggregates to build a fruiting body whose shape is species-specific and within which the cells sporulate. Early in this process, cells often pass through a "ripple phase" characterized by traveling linear, concentric, and spiral waves. These waves are different from the waves observed during slime mold aggregation that depend on diffusible morphogens, because myxobacteria communicate by direct contact. The difference is most dramatic when waves collide: rather than annihilating one another, myxobacterial waves appear to pass through one another unchanged. Under certain conditions, the spacing and location of the nascent fruiting bodies is determined by the wavelength and pattern of the waves. Later in fruiting body development, waves are replaced by streams of cells that circulate around small initial aggregates enlarging and rounding them. Still later, pairs of motile aggregates coalesce to form larger aggregates that develop into fruiting bodies. Here we present a mathematical model that quantitatively explains these wave and aggregation phenomena.

  11. Tubular aggregates: their association with myalgia.

    PubMed Central

    Niakan, E; Harati, Y; Danon, M J

    1985-01-01

    Three thousand consecutive muscle biopsies were reviewed for the presence of tubular aggregates and their association with clinical symptomatology. Tubular aggregates were detected in 19 patients (0.6%). Twelve of these nineteen patients had severe myalgia, and the most abundant tubular aggregates were found in biopsies of patients with myalgia. Seven patients had only myalgia as their clinical symptomatology with normal physical examination. An additional five patients with tubular aggregates and myalgia had concomitant amyotrophic lateral sclerosis (2) or neuropathy (3). The high incidence of myalgia associated with tubular aggregates in our patients and the fact that tubular aggregates originate from sarcoplasmic reticulum suggest a role played by this structure in the pathogenesis of myalgia. Images PMID:2995591

  12. Multiscale simulation of red blood cell aggregation

    NASA Astrophysics Data System (ADS)

    Bagchi, P.; Popel, A. S.

    2004-11-01

    In humans and other mammals, aggregation of red blood cells (RBC) is a major determinant to blood viscosity in microcirculation under physiological and pathological conditions. Elevated levels of aggregation are often related to cardiovascular diseases, bacterial infection, diabetes, and obesity. Aggregation is a multiscale phenomenon that is governed by the molecular bond formation between adjacent cells, morphological and rheological properties of the cells, and the motion of the extra-cellular fluid in which the cells circulate. We have developed a simulation technique using front tracking methods for multiple fluids that includes the multiscale characteristics of aggregation. We will report the first-ever direct computer simulation of aggregation of deformable cells in shear flows. We will present results on the effect of shear rate, strength of the cross-bridging bonds, and the cell rheological properties on the rolling motion, deformation and subsequent breakage of an aggregate.

  13. Sustainability in Supply Chain Management: Aggregate Planning from Sustainability Perspective.

    PubMed

    Türkay, Metin; Saraçoğlu, Öztürk; Arslan, Mehmet Can

    2016-01-01

    Supply chain management that considers the flow of raw materials, products and information has become a focal issue in modern manufacturing and service systems. Supply chain management requires effective use of assets and information that has far reaching implications beyond satisfaction of customer demand, flow of goods, services or capital. Aggregate planning, a fundamental decision model in supply chain management, refers to the determination of production, inventory, capacity and labor usage levels in the medium term. Traditionally standard mathematical programming formulation is used to devise the aggregate plan so as to minimize the total cost of operations. However, this formulation is purely an economic model that does not include sustainability considerations. In this study, we revise the standard aggregate planning formulation to account for additional environmental and social criteria to incorporate triple bottom line consideration of sustainability. We show how these additional criteria can be appended to traditional cost accounting in order to address sustainability in aggregate planning. We analyze the revised models and interpret the results on a case study from real life that would be insightful for decision makers. PMID:26807848

  14. Sustainability in Supply Chain Management: Aggregate Planning from Sustainability Perspective

    PubMed Central

    Türkay, Metin; Saraçoğlu, Öztürk; Arslan, Mehmet Can

    2016-01-01

    Supply chain management that considers the flow of raw materials, products and information has become a focal issue in modern manufacturing and service systems. Supply chain management requires effective use of assets and information that has far reaching implications beyond satisfaction of customer demand, flow of goods, services or capital. Aggregate planning, a fundamental decision model in supply chain management, refers to the determination of production, inventory, capacity and labor usage levels in the medium term. Traditionally standard mathematical programming formulation is used to devise the aggregate plan so as to minimize the total cost of operations. However, this formulation is purely an economic model that does not include sustainability considerations. In this study, we revise the standard aggregate planning formulation to account for additional environmental and social criteria to incorporate triple bottom line consideration of sustainability. We show how these additional criteria can be appended to traditional cost accounting in order to address sustainability in aggregate planning. We analyze the revised models and interpret the results on a case study from real life that would be insightful for decision makers. PMID:26807848

  15. Sustainability in Supply Chain Management: Aggregate Planning from Sustainability Perspective.

    PubMed

    Türkay, Metin; Saraçoğlu, Öztürk; Arslan, Mehmet Can

    2016-01-01

    Supply chain management that considers the flow of raw materials, products and information has become a focal issue in modern manufacturing and service systems. Supply chain management requires effective use of assets and information that has far reaching implications beyond satisfaction of customer demand, flow of goods, services or capital. Aggregate planning, a fundamental decision model in supply chain management, refers to the determination of production, inventory, capacity and labor usage levels in the medium term. Traditionally standard mathematical programming formulation is used to devise the aggregate plan so as to minimize the total cost of operations. However, this formulation is purely an economic model that does not include sustainability considerations. In this study, we revise the standard aggregate planning formulation to account for additional environmental and social criteria to incorporate triple bottom line consideration of sustainability. We show how these additional criteria can be appended to traditional cost accounting in order to address sustainability in aggregate planning. We analyze the revised models and interpret the results on a case study from real life that would be insightful for decision makers.

  16. Spokane Community College Library Serials Operation Handbook.

    ERIC Educational Resources Information Center

    Waesche, Betty; Cargill, Katie

    Listed are general policies for handling periodicals and specific policies for their acquisition, renewal, and processing, as well as procedures for checking in and claiming periodicals and handling duplicate copies. Flowcharts accompany procedural statements for claiming and checking-in periodicals and for dealing with duplicates. Specific duties…

  17. Operation C O P

    ERIC Educational Resources Information Center

    Mueck, Robert P.; Parker, Ashley

    2011-01-01

    Sometimes one never knows what sparks an idea or causes people to come together and take something forward. An example of this is Operation COP at the University of Maryland in College Park. Their version of the "See Something, Say Something" campaign is being touted as a crime prevention program, while it is at the same time an anti-terrorism…

  18. Diffusion Limited Aggregation: Algorithm optimization revisited

    NASA Astrophysics Data System (ADS)

    Braga, F. L.; Ribeiro, M. S.

    2011-08-01

    The Diffusion Limited Aggregation (DLA) model developed by Witten and Sander in 1978 is useful in modeling a large class of growth phenomena with local dependence. Besides its simplicity this aggregation model has a complex behavior that can be observed at the patterns generated. We propose on this work a brief review of some important proprieties of this model and present an algorithm to simulate a DLA aggregates that simpler and efficient compared to others found in the literature.

  19. Microbial aggregates in anaerobic wastewater treatment.

    PubMed

    Kosaric, N; Blaszczyk, R

    1990-01-01

    The phenomenon aggregation of anaerobic bacteria gives an opportunity to speed up the digestion rate during methanogenesis. The aggregates are mainly composed of methanogenic bacteria which convert acetate and H2/CO2 into methane. Other bacteria are also included in the aggregates but their concentration is rather small. The aggregates may also be formed during acetogenesis or even hydrolysis but such aggregates are not stable and disrupt quickly when not fed. A two stage process seems to be suitable when high concentrated solid waste must be treated. Special conditions are necessary to promote aggregate formation from methanogenic bacteria but aggregates once formed are stable without feeding even for a few years. The structure, texture and activity of bacterial aggregates depend on several parameters: (1)--temperature and pH, (2)--wastewater composition and (3)--hydrodynamic conditions within the reactor. The common influence of all these parameters is still rather unknown but some recommendations may be given. Temperature and pH should be maintained in the range which is optimal for methanogenic bacteria e.g. a temperature between 32 and 50 degrees C and a value pH between 6.5 and 7.5. Wastewaters should contain soluble wastes and the specific loading rate should be around one kgCOD(kgVSS)-1 d-1. The concentration of the elements influences aggregate composition and probably structure and texture. At high calcium concentration a change in the colour of the granules has been observed. Research is necessary to investigate the influence of other elements and organic toxicants on maintenance of the aggregates. Hydrodynamic conditions seem to influence the stability of the granules over long time periods. At low liquid stream rates, aggregates may starve and lysis within the aggregates is possible which results in hollowing of aggregates and their floating. At high liquid stream rates the aggregates may be disrupted and washed out of the reactor as a flocculent

  20. Neuronal aggregates: formation, clearance and spreading

    PubMed Central

    Lim, Junghyun; Yue, Zhenyu

    2015-01-01

    Summary Proteostasis is maintained by multiple cellular pathways, including protein synthesis, quality control and degradation. An imbalance of neuronal proteostasis, associated with protein misfolding and aggregation, leads to proteinopathies or neurodegeneration. While genetic variations and protein modifications contribute to aggregate formation, components of the proteostasis network dictate the fate of protein aggregates. Here we provide an overview of proteostasis pathways and their interplay (particularly autophagy) with the metabolism of disease-related proteins. We review recent studies on neuronal activity-mediated regulation of proteostasis and transcellular propagation of protein aggregates in the nervous system. Targeting proteostasis pathways therapeutically remains an attractive but challenging task. PMID:25710535

  1. Immunogenicity of therapeutic proteins: influence of aggregation.

    PubMed

    Ratanji, Kirsty D; Derrick, Jeremy P; Dearman, Rebecca J; Kimber, Ian

    2014-01-01

    The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the precise immunological and biochemical mechanisms responsible are poorly defined. In the context of biotherapeutic drug development and safety assessment, understanding the mechanisms underlying aggregate immunogenicity is of considerable interest. This review provides an overview of the phenomenon of protein aggregation, the production of unwanted aggregates during bioprocessing, and how the immune response to aggregated protein differs from that provoked by non-aggregated protein. Of particular interest is the nature of the interaction of aggregates with the immune system and how subsequent ADA responses are induced. Pathways considered here include 'classical' activation of the immune system involving antigen presenting cells and, alternatively, the breakdown of B-cell tolerance. Additionally, methods available to screen for aggregation and immunogenicity will be described. With an increased understanding of aggregation-enhanced immune responses, it may be possible to develop improved manufacturing and screening processes to avoid, or at least reduce, the problems associated with ADA.

  2. Bouncing behavior of microscopic dust aggregates

    NASA Astrophysics Data System (ADS)

    Seizinger, A.; Kley, W.

    2013-03-01

    Context. Bouncing collisions of dust aggregates within the protoplanetary disk may have a significant impact on the growth process of planetesimals. Yet, the conditions that result in bouncing are not very well understood. Existing simulations studying the bouncing behavior used aggregates with an artificial, very regular internal structure. Aims: Here, we study the bouncing behavior of sub-mm dust aggregates that are constructed applying different sample preparation methods. We analyze how the internal structure of the aggregate alters the collisional outcome and we determine the influence of aggregate size, porosity, collision velocity, and impact parameter. Methods: We use molecular dynamics simulations where the individual aggregates are treated as spheres that are made up of several hundred thousand individual monomers. The simulations are run on graphic cards (GPUs). Results: Statistical bulk properties and thus bouncing behavior of sub-mm dust aggregates depend heavily on the preparation method. In particular, there is no unique relation between the average volume filling factor and the coordination number of the aggregate. Realistic aggregates bounce only if their volume filling factor exceeds 0.5 and collision velocities are below 0.1 ms-1. Conclusions: For dust particles in the protoplanetary nebula we suggest that the bouncing barrier may not be such a strong handicap in the growth phase of dust agglomerates, at least in the size range of ≈100 μm.

  3. Swarms: Optimum aggregations of spacecraft

    NASA Technical Reports Server (NTRS)

    Mayer, H. L.

    1980-01-01

    Swarms are aggregations of spacecraft or elements of a space system which are cooperative in function, but physically isolated or only loosely connected. For some missions the swarm configuration may be optimum compared to a group of completely independent spacecraft or a complex rigidly integrated spacecraft or space platform. General features of swarms are induced by considering an ensemble of 26 swarms, examples ranging from Earth centered swarms for commercial application to swarms for exploring minor planets. A concept for a low altitude swarm as a substitute for a space platform is proposed and a preliminary design studied. The salient design feature is the web of tethers holding the 30 km swarm in a rigid two dimensional array in the orbital plane. A mathematical discussion and tutorial in tether technology and in some aspects of the distribution of services (mass, energy, and information to swarm elements) are included.

  4. Morphological classification of nanoceramic aggregates

    NASA Astrophysics Data System (ADS)

    Crosta, Giovanni F.; Kang, Bongwoo; Ospina, Carolina; Sung, Changmo

    2005-01-01

    Aluminum silicate nanoaggregates grown at near-room temperature on an organic template under a variety of experimental conditions have been imaged by transmission electron microscopy. Images have been automatically classified by an algorithm based on "spectrum enhancement", multivariate statistics and supervised optimization. Spectrum enhancement consists of subtracting, in the log scale, a known function of wavenumber from the angle averaged power spectral density of the image. Enhanced spectra of each image, after polynomial interpolation, have been regarded as morphological descriptors and as such submitted to principal components analysis nested with a multiobjective parameter optimization algorithm. The latter has maximized pairwise discrimination between classes of materials. The role of the organic template and of a reaction parameter on aggregate morphology has been assessed at two magnification scales. Classification results have also been related to crystal structure data derived from selected area electron diffraction patterns.

  5. Collisional Aggregation Due to Turbulence

    NASA Astrophysics Data System (ADS)

    Pumir, Alain; Wilkinson, Michael

    2016-03-01

    Collisions between particles suspended in a fluid play an important role in many physical processes. As an example, collisions of microscopic water droplets in clouds are a necessary step in the production of macroscopic raindrops. Collisions of dust grains are also conjectured to be important for planet formation in the gas surrounding young stars and to play a role in the dynamics of sand storms. In these processes, collisions are favored by fast turbulent motions. Here we review recent advances in the understanding of collisional aggregation due to turbulence. We discuss the role of fractal clustering of particles and caustic singularities of their velocities. We also discuss limitations of the Smoluchowski equation for modeling such processes. These advances lead to a semiquantitative understanding on the influence of turbulence on collision rates and point to deficiencies in the current understanding of rainfall and planet formation.

  6. Emerin expression in tubular aggregates.

    PubMed

    Manta, Panagiota; Terzis, Gerasimos; Papadimitriou, Constantinos; Kontou, Chrysanthi; Vassilopoulos, Demetris

    2004-06-01

    Emerin is an inner nuclear membrane protein that is mutated or not expressed in patients with X-linked Emery-Dreifuss muscular dystrophy (X-EDMD/EMD). Cytoplasmic localization of emerin in cultured cells or tissues has been reported, although this remains a controversial issue. Tubular aggregates (TAs) are pathological structures seen in the sarcoplasm of human skeletal muscle fibers in various disorders. The TAs derive from the sarcoplasmic reticulum (SR) and represent, probably, an adaptive response of the SR to various insults to the muscle fibers. In the present study, we present immunohistochemical evidence of emerin expression in TAs. Muscle biopsies with tubular aggregates from four male, unrelated patients were studied. The percentage of muscle fibers containing TAs varied between 5 and 20%. Routine histochemistry revealed intense reaction of TAs with NADH-TR, AMPDA, and NSE, but not with COX, SDH, myosin ATPase (pH 9.4, 4.3, 4.6), PAS, and Oil red O staining. Immunohistochemical study revealed strong immunostaining of TAs with antibodies against emerin and 7 SERCA2-ATPase. Immunostaining of TAs was also seen with antibodies against heat shock protein and dysferlin, but not with antibodies to lamin A, dystrophin, adhalin, beta, gamma, delta sarcoglycans, and merosin. These results suggest that emerin, an inner nuclear membrane protein, is present at the TAs. The interpretation and significance of this finding is discussed in relation to experimental data suggesting that normal emerin localization at the inner nuclear membrane depends on lamin A and mutations in the N-terminal domain of emerin cause mislocalization of the protein to the sarcoplasmic membranes.

  7. Detergent-mediated protein aggregation

    PubMed Central

    Neale, Chris; Ghanei, Hamed; Holyoake, John; Bishop, Russell E.; Privé, Gilbert G.; Pomès, Régis

    2016-01-01

    Because detergents are commonly used to solvate membrane proteins for structural evaluation, much attention has been devoted to assessing the conformational bias imparted by detergent micelles in comparison to the native environment of the lipid bilayer. Here, we conduct six 500-ns simulations of a system with >600,000 atoms to investigate the spontaneous self assembly of dodecylphosphocholine detergent around multiple molecules of the integral membrane protein PagP. This detergent formed equatorial micelles in which acyl chains surround the protein’s hydrophobic belt, confirming existing models of the detergent solvation of membrane proteins. In addition, unexpectedly, the extracellular and periplasmic apical surfaces of PagP interacted with the headgroups of detergents in other micelles 85 and 60% of the time, respectively, forming complexes that were stable for hundreds of nanoseconds. In some cases, an apical surface of one molecule of PagP interacted with an equatorial micelle surrounding another molecule of PagP. In other cases, the apical surfaces of two molecules of PagP simultaneously bound a neat detergent micelle. In these ways, detergents mediated the non-specific aggregation of folded PagP. These simulation results are consistent with dynamic light scattering experiments, which show that, at detergent concentrations ≥600 mM, PagP induces the formation of large scattering species that are likely to contain many copies of the PagP protein. Together, these simulation and experimental results point to a potentially generic mechanism of detergent-mediated protein aggregation. PMID:23466535

  8. College Student Suicide

    ERIC Educational Resources Information Center

    Taub, Deborah J.; Thompson, Jalonda

    2013-01-01

    Suicide is the second-leading cause of death among college students, and it is estimated that 1,088 college students die by suicide each year (National Mental Health Association and the Jed Foundation, 2002). This chapter presents the context of college student mental health within which the problem of college student suicide is situated. Because…

  9. Planning Makes College Possible.

    ERIC Educational Resources Information Center

    Belmont, Jean

    Written by a college financial aid administrator, this booklet is intended to help parents of younger children plan and prepare for the financial aspects of college education. After an introductory chapter, Chapter II lists current and projected (year 2000) costs at the most expensive colleges and at New York City colleges. Chapter III presents…

  10. Surviving Math, Surviving College

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2009-01-01

    According to a 2000 community college study by Miami Dade College (FL) President Emeritus Robert McCabe, 41 percent of students entering community colleges are underprepared in at least one basic skill area. A three-year study of community college students, published in 2009 by the National Center for Education Statistics, reported that 41 percent…

  11. Frederick Community College

    ERIC Educational Resources Information Center

    Haney, L. Richard; McClellan, Debralee

    2009-01-01

    Frederick Community College (FCC) is a comprehensive open-door community college that serves the citizens of Frederick County, Maryland, the state's largest county by size and seventh in population (230,000). It is located in central Maryland, equidistant from Baltimore and Washington, D.C. The college's character as a learning college is…

  12. College Now Student Handbook.

    ERIC Educational Resources Information Center

    Kingsborough Community Coll., Brooklyn, NY.

    This student handbook was compiled for high school students interested in New York City's Kingsborough Community College's College Now Program, a collaborative effort begun in 1984 to offer high school students an opportunity to take college-level courses, enhance their desire to go to college, and ease their transition from high school to…

  13. THE JUNIOR COLLEGE CHAIRMAN.

    ERIC Educational Resources Information Center

    WORTHEN, RICHARD

    THE RAPID DEVELOPMENT OF TWO-YEAR COLLEGES IMPLIES A SHIFT IN THE AMERICAN COLLEGE SCENE AND A RECONSIDERATION OF WHAT A COLLEGE SHOULD DO FOR ITS STUDENTS. "TEN POSTULATES" RELEVANT TO THE CONDUCTING OF A TWO-YEAR COLLEGE ENGLISH DEPARTMENT AND NINE CONCOMITANT RESPONSIBILITIES OF THE DEPARTMENT CHAIRMAN ARE LISTED. A CRITICAL ISSUE RESULTING…

  14. The Future College Executive.

    ERIC Educational Resources Information Center

    Boston Coll., Chestnut Hill, MA.

    This conference report examines various problems facing university administrators and discusses the future role of the executive in American colleges and universities. Conference papers concern the future college executive; efficiency, accountability and the college executive; administrative concerns; and the rights of college administrators. (MJM)

  15. ACT and College Success

    ERIC Educational Resources Information Center

    Bleyaert, Barbara

    2010-01-01

    What is the relationship between ACT scores and success in college? For decades, admissions policies in colleges and universities across the country have required applicants to submit scores from a college entrance exam, most typically the ACT (American College Testing) or SAT (Scholastic Aptitude Test). This requirement suggests that high school…

  16. Small Colleges, Big Missions.

    ERIC Educational Resources Information Center

    Griffin, W. A., Jr., Ed.

    This monograph by the members of the American Association of Community Colleges' Commission on Small and/or Rural Community Colleges shares small and rural community college experiences. In "Leaders through Community Service," Jacqueline D. Taylor provides a model for how small and rural community colleges can be involved in building leaders…

  17. PRODUCTION OF CONSTRUCTION AGGREGATES FROM FLUE GAS DESULFURIZATION SLUDGE

    SciTech Connect

    1998-12-01

    Through a cooperative agreement with DOE, the Research and Development Department of CONSOL Inc. (CONSOL R and D) is teaming with SynAggs, Inc. and Duquesne Light to design, construct, and operate a 500 lb/h continuous pilot plant to produce road construction aggregate from a mixture of wet flue gas desulfurization (FGD) sludge, fly ash, and other components. The proposed project is divided into six tasks: (1) Project Management; (2) Mix Design Evaluation; (3) Process Design; (4) Construction; (5) Start-Up and Operation; and (6) Reporting. In this quarter, Tasks 1 and 2 were completed. A project management plan (Task 1) was issued to DOE on October 22, 1998 . The mix design evaluation (Task 2) with Duquesne Light Elrama Station FGD sludge and Allegheny Power Hatfields Ferry Station fly ash was completed. Eight semi-continuous bench-scale tests were conducted to examine the effects of mix formulation on aggregate properties. A suitable mix formulation was identified to produce aggregates that meet specifications of the American Association of State High Transport Officials (AASHTO) as Class A aggregate for use in highway construction. The mix formulation was used in designing the flow sheet of the pilot plant. The process design (Task 3) is approximately 80% completed. Equipment was evaluated to comply with design requirements. The design for the curing vessel was completed by an outside engineering firm. All major equipment items for the pilot plant, except the curing vessel, were ordered. Pilot plant construction (Task 4) was begun in October. The Hazardous Substance Plan was issued to DOE. The Allegheny County (PA) Heat Department determined that an air emission permit is not required for operation of the pilot plant.

  18. The Twelve College Cost-Quality Study.

    ERIC Educational Resources Information Center

    McKinsey & Co., Inc., Washington, DC.

    Twelve colleges participated in a cost quality study. These colleges were: Allegheny College, Bryn Mawr College, Buchnell University, Carnegie-Mellon University, Chatham College, Dickinson College, Franklin and Marshall College, Gettysburg College, Haverford College, Lafayette College, Lehigh University, and Swarthmore College. The study is an…

  19. Formation and Growth of Stacking Fault Tetrahedra in Ni via Vacancy Aggregation Mechanism

    SciTech Connect

    Aidhy, Dilpuneet S.; Lu, Chenyang; Jin, Ke; Bei, Hongbin; Zhang, Yanwen; Wang, Lumin; Weber, William J.

    2015-12-29

    Using molecular dynamics simulations, the formation and growth of stacking fault tetrahedra (SFT) are captured by vacancy cluster diffusion and aggregation mechanisms in Ni. The vacancytetrahedron acts as a nucleation point for SFT formation. Simulations show that perfect SFT can grow to the next size perfect SFT via a vacancy aggregation mechanism. The stopping and range of ions in matter (SRIM) calculations and transmission electron microscopy (TEM) observations reveal that SFT can form farther away from the initial cascade-event locations, indicating the operation of diffusion-based vacancy-aggregation mechanism.

  20. Flow Partitioning in Fully Saturated Soil Aggregates

    SciTech Connect

    Yang, Xiaofan; Richmond, Marshall C.; Scheibe, Timothy D.; Perkins, William A.; Resat, Haluk

    2014-03-30

    Microbes play an important role in facilitating organic matter decomposition in soils, which is a major component of the global carbon cycle. Microbial dynamics are intimately coupled to environmental transport processes, which control access to labile organic matter and other nutrients that are needed for the growth and maintenance of microorganisms. Transport of soluble nutrients in the soil system is arguably most strongly impacted by preferential flow pathways in the soil. Since the physical structure of soils can be characterized as being formed from constituent micro aggregates which contain internal porosity, one pressing question is the partitioning of the flow among the “inter-aggregate” and “intra-aggregate” pores and how this may impact overall solute transport within heterogeneous soil structures. The answer to this question is particularly important in evaluating assumptions to be used in developing upscaled simulations based on highly-resolved mechanistic models. We constructed a number of diverse multi-aggregate structures with different packing ratios by stacking micro-aggregates containing internal pores and varying the size and shape of inter-aggregate pore spacing between them. We then performed pore-scale flow simulations using computational fluid dynamics methods to determine the flow patterns in these aggregate-of-aggregates structures and computed the partitioning of the flow through intra- and inter-aggregate pores as a function of the spacing between the aggregates. The results of these numerical experiments demonstrate that soluble nutrients are largely transported via flows through inter-aggregate pores. Although this result is consistent with intuition, we have also been able to quantify the relative flow capacity of the two domains under various conditions. For example, in our simulations, the flow capacity through the aggregates (intra-aggregate flow) was less than 2% of the total flow when the spacing between the aggregates

  1. Acetal phosphatidic acids: novel platelet aggregating agents.

    PubMed

    Brammer, J P; Maguire, M H; Walaszek, E J; Wiley, R A

    1983-05-01

    1 Palmitaldehyde, olealdehyde and linolealdehyde acetal phosphatidic acids induced rapid shape change and dose-dependent biphasic aggregation of human platelets in platelet-rich plasma; aggregation was reversible at low doses and irreversible at high doses of the acetal phosphatidic acids. The palmitaldehyde congener elicited monophasic dose-dependent aggregation of sheep platelets in platelet-rich plasma.2 The threshold concentration for palmitaldehyde acetal phosphatidic acid (PGAP)-induced platelet aggregation was 2.5-5 muM for human platelets and 0.25-0.5 muM for sheep platelets. PGAP was 4-5 times as potent versus human platelets as the olealdehyde and linolealdehyde acetal phosphatidic acids, which were equipotent.3 PGAP-induced irreversible aggregation of [(14)C]-5-hydroxytryptamine ([(14)C]-5-HT)-labelled human platelets in platelet-rich plasma was accompanied by release of 44.0+/-2.4% (s.e.) of the platelet [(14)C]-5-HT; reversible aggregation was not associated with release. In contrast, PGAP-induced release of [(14)C]-5-HT-labelled sheep platelets was dose-dependent.4 The adenosine diphosphate (ADP) antagonist, 2-methylthio-AMP, and the cyclo-oxygenase inhibitor, aspirin, abolished PGAP-induced second phase aggregation and release in human platelets but did not affect the first, reversible, phase of aggregation. Both the first and second phases of PGAP-induced aggregation were abolished by chlorpromazine, by the phospholipase A(2) inhibitor, mepacrine, and by nmolar concentrations of prostaglandin E(1) (PGE(1)); these agents abolished the second, but not the first phase of ADP-induced aggregation.5 The related phospholipids, lecithin, lysolecithin and phosphatidic acid, at <100 muM, neither induced aggregation of human platelets in platelet-rich plasma, nor modified PGAP-induced aggregation; 1-palmityl lysophosphatidic acid elicited aggregation of human platelets at a threshold concentration of 100 muM.6 It is concluded that the acetal phosphatidic acids

  2. Usefulness of the Co-op Experience: A Study of Community College Students.

    ERIC Educational Resources Information Center

    Krebs, Uwe (Hugh)

    1987-01-01

    Analyzes the perceived usefulness of the co-op experience of community college graduates from the Production and Operating Management and the Marketing Management programs at Centennial College in Ontario. (JOW)

  3. Succession of Protists on Estuarine Aggregates.

    PubMed

    Wörner; Zimmerman-Timm; Kausch

    2000-08-01

    Colonization by and succession of bacteria and bacterivorous protists on laboratory-made aggregates were determined over a period of 14 days during winter and spring in 1997. Aggregates were generated from natural water from the limnetic zone of the Elbe Estuary using a tilting tube roller system. Within 1 h after the beginning of the experiments, macroaggregates started to form. Aggregates reached a maximum size of 1 mm with a tendency toward large sizes at the end of the experiment after the 10th day. On the first day, high bacterial densities of more than 10(9) cells ml(-1) were detected within the aggregates. The abundances of flagellates and ciliates within aggregates were also two or three orders of magnitude higher than in the surrounding water. Densities of aggregate associated organisms are comparable to those occuring in sediments. The first protistan colonizers on the aggregates were small heterotrophic flagellates, such as choanoflagellates and small euglenids. Later, beginning on the 4th day, small sarcodines and ciliates became abundant. The most abundant ciliates associated with aggregates were small species of the Hypotrichia, Cyrtophorida, and Hymenostomata. After 9 days, large omnivorous and carnivorous ciliates, such as large members of the Hypotrichia and the Pleurostomatida, occurred. In spring, large heterotrophic flagellates and amebae also appeared at this time. These findings indicated the existence of a succession of protists on newly formed aggregates and a microbial food net within the aggregates based on bacterial production. Additionally, most of the species observed during this study were adapted for living on surfaces. In natural environments they are more common in benthic than in pelagic environments. For them, aggregates are havens in the water column comparable to sediment communities.

  4. Preformed Seeds Modulate Native Insulin Aggregation Kinetics.

    PubMed

    Dutta, Colina; Yang, Mu; Long, Fei; Shahbazian-Yassar, Reza; Tiwari, Ashutosh

    2015-12-10

    Insulin aggregates under storage conditions via disulfide interchange reaction. It is also known to form aggregates at the site of repeated injections in diabetes patients, leading to injection amyloidosis. This has fueled research in pharmaceutical and biotechnology industry as well as in academia to understand factors that modulate insulin stability and aggregation. The main aim of this study is to understand the factors that modulate aggregation propensity of insulin under conditions close to physiological and measure effect of "seeds" on aggregation kinetics. We explored the aggregation kinetics of insulin at pH 7.2 and 37 °C in the presence of disulfide-reducing agent dithiothreitol (DTT), using spectroscopy (UV-visible, fluorescence, and Fourier transform infrared spectroscopy) and microscopy (scanning electron microscopy, atomic force microscopy) techniques. We prepared insulin "seeds" by incubating disulfide-reduced insulin at pH 7.2 and 37 °C for varying lengths of time (10 min to 12 h). These seeds were added to the native protein and nucleation-dependent aggregation kinetics was measured. Aggregation kinetics was fastest in the presence of 10 min seeds suggesting they were nascent. Interestingly, intermediate seeds (30 min to 4 h incubation) resulted in formation of transient fibrils in 4 h that converted to amorphous aggregates upon longer incubation of 24 h. Overall, the results show that insulin under disulfide reducing conditions at pH and temperature close to physiological favors amorphous aggregate formation and seed "maturity" plays an important role in nucleation dependent aggregation kinetics.

  5. Impact of Particle Aggregation on Nanoparticle Reactivity

    NASA Astrophysics Data System (ADS)

    Jassby, David

    2011-12-01

    The prevalence of nanoparticles in the environment is expected to grow in the coming years due to their increasing pervasiveness in consumer and industrial applications. Once released into the environment, nanoparticles encounter conditions of pH, salinity, UV light, and other solution conditions that may alter their surface characteristics and lead to aggregation. The unique properties that make nanoparticles desirable are a direct consequence of their size and increased surface area. Therefore, it is critical to recognize how aggregation alters the reactive properties of nanomaterials, if we wish to understand how these properties are going to behave once released into the environment. The size and structure of nanoparticle aggregates depend on surrounding conditions, including hydrodynamic ones. Depending on these conditions, aggregates can be large or small, tightly packed or loosely bound. Characterizing and measuring these changes to aggregate morphology is important to understanding the impact of aggregation on nanoparticle reactive properties. Examples of decreased reactivity due to aggregation include the case where tightly packed aggregates have fewer available surface sites compared to loosely packed ones; also, photocatalytic particles embedded in the center of large aggregates will experience less light when compared to particles embedded in small aggregates. However, aggregation also results in an increase in solid-solid interfaces between nanoparticles. This can result in increased energy transfer between neighboring particles, surface passivation, and altered surface tension. These phenomena can lead to an increase in reactivity. The goal of this thesis is to examine the impacts of aggregation on the reactivity of a select group of nanomaterials. Additionally, we examined how aggregation impacts the removal efficiency of fullerene nanoparticles using membrane filtration. The materials we selected to study include ZnS---a metal chalcogenide

  6. Joseph Lister's first operation

    PubMed Central

    Richardson, Ruth; Rhodes, Bryan

    2013-01-01

    Joseph Lister was still a medical student in 1851 when he served as house surgeon at University College Hospital, London, under John Erichsen. Here we report the first major operation that Lister accomplished, hitherto apparently missed by biographers. We chart his exemplary dealings with an emergency case of eviscerating stab wound in a woman brought to casualty at night, when he had been in post for less than a month. The case demonstrates Lister's fundamental competence at an early stage in his training. We outline the context of debate and controversy over the repair of lacerated gut at the time, and argue that Lister's period at University College London was profoundly formative.

  7. Automated Data Aggregation for Time-Series Analysis: Study Case on Anaesthesia Data Warehouse.

    PubMed

    Lamer, Antoine; Jeanne, Mathieu; Ficheur, Grégoire; Marcilly, Romaric

    2016-01-01

    Data stored in operational databases are not reusable directly. Aggregation modules are necessary to facilitate secondary use. They decrease volume of data while increasing the number of available information. In this paper, we present four automated engines of aggregation, integrated into an anaesthesia data warehouse. Four instances of clinical questions illustrate the use of those engines for various improvements of quality of care: duration of procedure, drug administration, assessment of hypotension and its related treatment.

  8. Automated Data Aggregation for Time-Series Analysis: Study Case on Anaesthesia Data Warehouse.

    PubMed

    Lamer, Antoine; Jeanne, Mathieu; Ficheur, Grégoire; Marcilly, Romaric

    2016-01-01

    Data stored in operational databases are not reusable directly. Aggregation modules are necessary to facilitate secondary use. They decrease volume of data while increasing the number of available information. In this paper, we present four automated engines of aggregation, integrated into an anaesthesia data warehouse. Four instances of clinical questions illustrate the use of those engines for various improvements of quality of care: duration of procedure, drug administration, assessment of hypotension and its related treatment. PMID:27071886

  9. 24 CFR 58.32 - Project aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other activities and actions. (See 40 CFR 1508.25(a)). (2) Consider reasonable alternative courses of... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Project aggregation. 58.32 Section... Environmental Review Process: Documentation, Range of Activities, Project Aggregation and Classification §...

  10. 24 CFR 58.32 - Project aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other activities and actions. (See 40 CFR 1508.25(a)). (2) Consider reasonable alternative courses of... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Project aggregation. 58.32 Section... Environmental Review Process: Documentation, Range of Activities, Project Aggregation and Classification §...

  11. 48 CFR 514.270 - Aggregate awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Aggregate awards. 514.270 Section 514.270 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 514.270 Aggregate awards....

  12. Streaming instability of aggregating slime mold amoebae

    NASA Astrophysics Data System (ADS)

    Levine, Herbert; Reynolds, William

    1991-05-01

    We propose a new model of aggregation in the cellular slime mold D. Discoideum. Our approach couples the excitable signaling system to amoeba chemotaxis; the resultant system of equations is tractable to analytical and numerical approaches. Using our model, we derive the existence of a streaming instability for the concentric target aggregation pattern.

  13. 24 CFR 58.32 - Project aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Environmental Review Process: Documentation, Range of Activities, Project Aggregation and Classification § 58.32... the total project must be listed and described by the responsible entity in the environmental review... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Project aggregation. 58.32...

  14. 24 CFR 58.32 - Project aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Environmental Review Process: Documentation, Range of Activities, Project Aggregation and Classification § 58.32... the total project must be listed and described by the responsible entity in the environmental review... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Project aggregation. 58.32...

  15. Choosing Aggregation Rules for Composite Indicators

    ERIC Educational Resources Information Center

    Munda, Giuseppe

    2012-01-01

    From a formal point of view, a composite indicator is an aggregate of all dimensions, objectives, individual indicators and variables used for its construction. This implies that what defines a composite indicator is the set of properties underlying its mathematical aggregation convention. In this article, I try to revise the theoretical debate on…

  16. Teaching Aggregate Demand and Supply Models

    ERIC Educational Resources Information Center

    Wells, Graeme

    2010-01-01

    The author analyzes the inflation-targeting model that underlies recent textbook expositions of the aggregate demand-aggregate supply approach used in introductory courses in macroeconomics. He shows how numerical simulations of a model with inflation inertia can be used as a tool to help students understand adjustments in response to demand and…

  17. 7 CFR 1.6 - Aggregating requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Aggregating requests. 1.6 Section 1.6 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.6 Aggregating requests. When an agency reasonably believes that a requester, or a group of requesters acting in...

  18. 42 CFR 411.106 - Aggregation rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Aggregation rules. 411.106 Section 411.106 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... Under Group Health Plans: General Provisions § 411.106 Aggregation rules. The following rules apply...

  19. 7 CFR 1.6 - Aggregating requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Aggregating requests. 1.6 Section 1.6 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.6 Aggregating requests. When an agency reasonably believes that a requester, or a group of requesters acting in...

  20. Biomass round bales infield aggregation logistic scenarios

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Biomass bales often need to be aggregated (collected into groups and transported) to a field-edge stack for temporary storage for feedlots or processing facilities. Aggregating the bales with the least total distance involved is a goal of producers and bale handlers. Several logistics scenarios for ...

  1. Aggregate size distribution of the soil loss

    NASA Astrophysics Data System (ADS)

    Szabó, Judit Alexandra; Jakab, Gergely; Szabó, Boglárka; Józsa, Sándor; Szalai, Zoltán; Centeri, Csaba

    2016-04-01

    In agricultural areas the soil erosion and soil loss estimation is vital information in long-term planning. During the initial period of the erosion a part of the soil particles and aggregates get transportable and nutrients and organic matter could be transported due to the effect of water or wind. This preliminary phase was studied with laboratory-scale rainfall simulator. Developed surface crust and aggregate size composition of the runoff was examined in six different slope-roughness-moisture content combination of a Cambisol and a Regosol. The ratio of micro- and macro aggregates in the runoff indicate the stability of the aggregates and determine the transport capacity of the runoff. Both soil samples were taken from field where the water erosion is a potential hazard. During the experiment the whole amount of runoff and sediment was collected through sieve series to a bucket to separate the micro- and macro aggregates. In case of both samples the micro aggregates dominate in the runoff and the runoff rates are similar. Although the runoff of the Regosol - with dominant >1000μm macro aggregate content - contained almost nothing but <50μm sized micro aggregates. Meanwhile the runoff of the Cambisol - with more balanced micro and macro aggregate content - contained dominantly 50-250μm sized micro aggregates and in some case remarkable ratio 250-1000μm sized macro aggregates. This difference occurred because the samples are resistant against drop erosion differently. In case of both sample the selectivity of the erosion and substance matrix redistribution manifested in mineral crusts in the surface where the quartz deposited in place while the lighter organic matter transported with the sediment. The detachment of the aggregates and the redistribution of the particles highly effect on the aggregate composition of the runoff which is connected with the quality of the soil loss. So while the estimation of soil loss quantity is more or less is easy, measuring

  2. Simulating aggregate dynamics in ocean biogeochemical models

    NASA Astrophysics Data System (ADS)

    Jackson, George A.; Burd, Adrian B.

    2015-04-01

    The dynamics of elements in the water column is complex, depending on multiple biological and physical processes operating at very different physical scales. Coagulation of particulate material is important for transforming particles and moving them in the water column. Mechanistic models of coagulation processes provide a means to predict these processes, help interpret observations, and provide insight into the processes occurring. However, most model applications have focused on describing simple marine systems and mechanisms. We argue that further model development, in close collaboration with field and experimental scientists, is required in order to extend the models to describe the large-scale elemental distributions and interactions being studied as part of GEOTRACES. Models that provide a fundamental description of trace element-particle interactions are required as are experimental tests of the mechanisms involved and the predictions arising from models. However, a comparison between simple and complicated models of aggregation and trace metal provides a means for understanding the implications of simplifying assumptions and providing guidance as to which simplifications are needed.

  3. Community Colleges Demand More from Their Buildings.

    ERIC Educational Resources Information Center

    Adams, Matthew C.

    1998-01-01

    Discusses the financial and operational difficulties inherent in community college facilities management. It explains why the primary source of plant operation cost and waste starts with satisfying the scheduling and changing educational needs of its students. Problems in planning and executing major maintenance activities are also addressed. (GR)

  4. Therapeutic Protein Aggregation: Mechanisms, Design, and Control

    PubMed Central

    Roberts, Christopher J.

    2014-01-01

    While it is well known that proteins are only marginally stable in their folded states, it is often less well appreciated that most proteins are inherently aggregation-prone in their unfolded or partially unfolded states, and the resulting aggregates can be extremely stable and long-lived. For therapeutic proteins, aggregates are a significant risk factor for deleterious immune responses in patients, and can form via a variety of mechanisms. Controlling aggregation using a mechanistic approach may allow improved design of therapeutic protein stability, as a complement to existing design strategies that target desired protein structures and function. Recent results highlight the importance of balancing protein environment with the inherent aggregation propensities of polypeptide chains. PMID:24908382

  5. CHARGING OF AGGREGATE GRAINS IN ASTROPHYSICAL ENVIRONMENTS

    SciTech Connect

    Ma, Qianyu; Matthews, Lorin S.; Hyde, Truell W.; Land, Victor

    2013-02-15

    The charging of dust grains in astrophysical environments has been investigated with the assumption that these grains are homogeneous spheres. However, there is evidence which suggests that many grains in astrophysical environments are irregularly shaped aggregates. Recent studies have shown that aggregates acquire higher charge-to-mass ratios due to their complex structures, which in turn may alter their subsequent dynamics and evolution. In this paper, the charging of aggregates is examined including secondary electron emission and photoemission in addition to primary plasma currents. The results show that the equilibrium charge on aggregates can differ markedly from spherical grains with the same mass, but that the charge can be estimated for a given environment based on structural characteristics of the grain. The 'small particle effect' due to secondary electron emission is also important for de terming the charge of micron-sized aggregates consisting of nano-sized particles.

  6. Competitive aggregation dynamics using phase wave signals.

    PubMed

    Sakaguchi, Hidetsugu; Maeyama, Satomi

    2014-10-21

    Coupled equations of the phase equation and the equation of cell concentration n are proposed for competitive aggregation dynamics of slime mold in two dimensions. Phase waves are used as tactic signals of aggregation in this model. Several aggregation clusters are formed initially, and target patterns appear around the localized aggregation clusters. Owing to the competition among target patterns, the number of the localized aggregation clusters decreases, and finally one dominant localized pattern survives. If the phase equation is replaced with the complex Ginzburg-Landau equation, several spiral patterns appear, and n is localized near the center of the spiral patterns. After the competition among spiral patterns, one dominant spiral survives. PMID:24956327

  7. Formation of Tethers from Spreading Cellular Aggregates.

    PubMed

    Beaune, Grégory; Winnik, Françoise M; Brochard-Wyart, Françoise

    2015-12-01

    Membrane tubes are commonly extruded from cells and vesicles when a point-like force is applied on the membrane. We report here the unexpected formation of membrane tubes from lymph node cancer prostate (LNCaP) cell aggregates in the absence of external applied forces. The spreading of LNCaP aggregates deposited on adhesive glass substrates coated with fibronectin is very limited because cell-cell adhesion is stronger than cell-substrate adhesion. Some cells on the aggregate periphery are very motile and try to escape from the aggregate, leading to the formation of membrane tubes. Tethered networks and exchange of cargos between cells were observed as well. Growth of the tubes is followed by either tube retraction or tube rupture. Hence, even very cohesive cells are successful in escaping aggregates, which may lead to epithelial mesenchymal transition and tumor metastasis. We interpret the dynamics of formation and retraction of tubes in the framework of membrane mechanics. PMID:26509898

  8. Imbibition kinetics of spherical colloidal aggregates.

    PubMed

    Debacker, A; Makarchuk, S; Lootens, D; Hébraud, P

    2014-07-11

    The imbibition kinetics of a millimeter-sized aggregate of 300 nm diameter colloidal particles by a wetting pure solvent is studied. Three successive regimes are observed. First, the imbibition proceeds by compressing the air inside the aggregate. Next, the solvent stops when the pressure of the compressed air is equal to the excess of capillary pressure at the meniscus of the wetting solvent in the porous aggregate. The interface is pinned and the aggregate slowly degases up to the point where the pressure of the entrapped air stops decreasing and is controlled by the capillary pressure. Finally, the imbibition starts again at a constant excess of pressure, smaller than the capillary pressure but larger than the one of the atmosphere. This last stage leads to the complete infiltration of the aggregate. PMID:25062241

  9. New Mexico aggregate production sites, 1997-1999

    USGS Publications Warehouse

    Orris, Greta J.

    2000-01-01

    This report presents data, including latitude and longitude, for aggregate sites in New Mexico that were believed to be active in the period 1997-1999. The data are presented in paper form in Part A of this report and as Microsoft Excel 97 and Data Interchange Format (DIF) files in Part B. The work was undertaken as part of the effort to update information for the National Atlas. This compilation includes data from: the files of U.S. Geological Survey (USGS); company contacts; the New Mexico Bureau of Mines and Mineral Resources, New Mexico Bureau of Mine Inspection, and the Mining and Minerals Division of the New Mexico Energy, Minerals and Natural Resources Department (Hatton and others, 1998); the Bureau of Land Management Information; and direct communications with some of the aggregate operators. Additional information on most of the sites is available in Hatton and others (1998).

  10. Reconsidering the mechanism of polyglutamine peptide aggregation.

    PubMed

    Lee, Christine C; Walters, Robert H; Murphy, Regina M

    2007-11-01

    There are at least nine neurodegenerative diseases associated with proteins that contain an unusually expanded polyglutamine domain, the best known of which is Huntington's disease. In all of these diseases, the mutant protein aggregates into neuronal inclusions; it is generally, although not universally, believed that protein aggregation is an underlying cause of the observed neuronal degeneration. In an effort to examine the role of polyglutamine in facilitating protein aggregation, investigators have used synthetic polyglutamine peptides as model systems. Analysis of kinetic data led to the conclusions that aggregation follows a simple nucleation-elongation mechanism characterized by a significant lag time, during which the peptide is monomeric, and that the nucleus is a monomer in a thermodynamically unfavorable conformation [Chen, S. M., et al. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11884-11889]. We re-examined this hypothesis by measuring the aggregation kinetics of the polyglutamine peptide K2Q23K2, using sedimentation, static and dynamic light scattering, and size exclusion chromatography. Our data show that during the lag time in sedimentation kinetics, there is substantial organization of the peptide into soluble linear aggregates. These aggregates have no regular secondary structure as measured by circular dichroism but have particle dimensions and morphologies similar to those of mature insoluble aggregates. The soluble aggregates constitute approximately 30% of the total peptide mass, form rapidly, and continue to grow over a period of hours to days, eventually precipitating. Once insoluble aggregates form, loss of monomer from the solution phase continues. Our data support an assembly mechanism for polyglutamine peptide more complex than that previously proposed.

  11. Classification and Characterization of Therapeutic Antibody Aggregates

    PubMed Central

    Joubert, Marisa K.; Luo, Quanzhou; Nashed-Samuel, Yasser; Wypych, Jette; Narhi, Linda O.

    2011-01-01

    A host of diverse stress techniques was applied to a monoclonal antibody (IgG2) to yield protein particles with varying attributes and morphologies. Aggregated solutions were evaluated for percent aggregation, particle counts, size distribution, morphology, changes in secondary and tertiary structure, surface hydrophobicity, metal content, and reversibility. Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, J. (2011) J. Biol. Chem. 286, 25134–25144). Aggregates were categorized into seven discrete classes, based on the traits described. Several additional molecules (from the IgG1 and IgG2 subtypes as well as intravenous IgG) were stressed and found to be defined with the same classification system. The mechanism of protein aggregation and the type of aggregate formed depends on the nature of the stress applied. Different IgG molecules appear to aggregate by a similar mechanism under the same applied stress. Aggregates created by harsh mechanical stress showed the largest number of subvisible particles, and the class generated by thermal stress displayed the largest number of visible particles. Most classes showed a disruption of the higher order structure, with the degree of disorder depending on the stress process. Particles in all classes (except thermal stress) were at least partially reversible upon dilution in pH 5 buffer. High copper content was detected in isolated metal-catalyzed aggregates, a stress previously shown to produce immunogenic aggregates. In conclusion, protein aggregates can be a very heterogeneous population, whose qualities are the result of the type of stress that was experienced. PMID:21454532

  12. Aggregated Residential Load Modeling Using Dynamic Bayesian Networks

    SciTech Connect

    Vlachopoulou, Maria; Chin, George; Fuller, Jason C.; Lu, Shuai

    2014-09-28

    Abstract—It is already obvious that the future power grid will have to address higher demand for power and energy, and to incorporate renewable resources of different energy generation patterns. Demand response (DR) schemes could successfully be used to manage and balance power supply and demand under operating conditions of the future power grid. To achieve that, more advanced tools for DR management of operations and planning are necessary that can estimate the available capacity from DR resources. In this research, a Dynamic Bayesian Network (DBN) is derived, trained, and tested that can model aggregated load of Heating, Ventilation, and Air Conditioning (HVAC) systems. DBNs can provide flexible and powerful tools for both operations and planing, due to their unique analytical capabilities. The DBN model accuracy and flexibility of use is demonstrated by testing the model under different operational scenarios.

  13. Sans study of asphaltene aggregation

    SciTech Connect

    Overfield, R.E.; Sheu, E.Y.; Sinha, S.K.; Liang, K.S. )

    1988-06-01

    The colloidal properties of asphaltenes have long been recognized from peculiarities in their solubility and colligative properties. A layered micellar model or asphaltenes was proposed by others in which a highly condensed alkyl aromatic formed the central part, and molecules of decreasingly aromatic character (resins) clustered around them. Numerous studies, based on a variety of techniques such as ultracentrifugation and electron microscopy indicated a particulate nature for asphaltenes with size 20-40 A diameter. Others have proposed a refined model based on x-ray diffraction and small angle scattering. In this model, interactions between flat sheets of condensed aromatic rings form the central ''crystallite'' part of a spherical particle with the outer part being comprised of the aliphatic positions of the same molecules. These particles are bunched together with some degree of entanglement into ''micelles''. Concentration and solvent dependent radii of gyration, ranging from 30-50 A were reported. The aggregation creates a good deal of uncertainty as to the true molecular size or weight of asphaltenes. Neutron scattering offers novel contrast relative to light scattering (refractive index) and x-ray scattering (electron density). This is because the scattering length of proton is negative, whereas that from deuterium and other nuclei such as C, S, O, and N are positive. Thus by replacing hydrogen with deuterium in either the solvent or the scatterer the contrast can be varied, and different parts of the molecule can be highlighted.

  14. Anisotropic diffusion-limited aggregation.

    PubMed

    Popescu, M N; Hentschel, H G E; Family, F

    2004-06-01

    Using stochastic conformal mappings, we study the effects of anisotropic perturbations on diffusion-limited aggregation (DLA) in two dimensions. The harmonic measure of the growth probability for DLA can be conformally mapped onto a constant measure on a unit circle. Here we map m preferred directions for growth to a distribution on the unit circle, which is a periodic function with m peaks in [-pi,pi) such that the angular width sigma of the peak defines the "strength" of anisotropy kappa= sigma(-1) along any of the m chosen directions. The two parameters (m,kappa) map out a parameter space of perturbations that allows a continuous transition from DLA (for small enough kappa ) to m needlelike fingers as kappa--> infinity. We show that at fixed m the effective fractal dimension of the clusters D(m,kappa) obtained from mass-radius scaling decreases with increasing kappa from D(DLA) approximately 1.71 to a value bounded from below by D(min) = 3 / 2. Scaling arguments suggest a specific form for the dependence of the fractal dimension D(m,kappa) on kappa for large kappa which compares favorably with numerical results. PMID:15244564

  15. A survey of natural aggregate properties and characteristics important in remote sensing and airborne geophysics

    USGS Publications Warehouse

    Knepper, D.H.; Langer, W.H.; Miller, S.

    1995-01-01

    Natural aggregate is vital to the construction industry. Although natural aggregate is a high volume/low value commodity that is abundant, new sources are becoming increasingly difficult to find and develop because of rigid industry specifications, political considerations, development and transportation costs, and environmental concerns. There are two primary sources of natural aggregate: (1) exposed or near-surface bedrock that can be crushed, and (2) deposits of sand and gravel. Remote sensing and airborne geophysics detect surface and near-surface phenomena, and may be useful for detecting and mapping potential aggregate sources; however, before a methodology for applying these techniques can be developed, it is necessary to understand the type, distribution, physical properties, and characteristics of natural aggregate deposits. The distribution of potential aggregate sources is closely tied to local geologic history. Conventional exploration for natural aggregate deposits has been largely a ground-based operation, although aerial photographs and topographic maps have been extensively used to target possible deposits. Today, the exploration process also considers factors such as the availability of the land, space and water supply for processing, political and environmental factors, and distance from the market; exploration and planning cannot be separated. There are many physical properties and characteristics by which to judge aggregate material for specific applications; most of these properties and characteristics pertain only to individual aggregate particles. The application of remote sensing and airborne geophysical measurements to detecting and mapping potential aggregate sources, however, is based on intrinsic bulk physical properties and extrinsic characteristics of the deposits that can be directly measured, mathematically derived from measurement, or interpreted with remote sensing and geophysical data. ?? 1995 Oxford UniversityPress.

  16. Commercial Demonstration of the Manufactured Aggregate Processing Technology Utilizing Spray Dryer Ash

    SciTech Connect

    Milton Wu; Paul Yuran

    2006-12-31

    Universal Aggregates LLC (UA) was awarded a cost sharing Co-operative Agreement from the Department of Energy (DOE) through the Power Plant Improvement Initiative Program (PPII) to design, construct and operate a lightweight aggregate manufacturing plant at the Birchwood Power Facility in King George, Virginia in October 2001. The Agreement was signed in November 2002. The installation and start-up expenses for the Birchwood Aggregate Facility are $19.5 million. The DOE share is $7.2 million (37%) and the UA share is $12.3 million (63%). The original project team consists of UA, SynAggs, LLC, CONSOL Energy Inc. and P. J. Dick, Inc. Using 115,000 ton per year of spray dryer ash (SDA), a dry FGD by-product from the power station, UA will produce 167,000 tons of manufactured lightweight aggregate for use in production of concrete masonry units (CMU). Manufacturing aggregate from FGD by-products can provide an economical high-volume use and substantially expand market for FGD by-products. Most of the FGD by-products are currently disposed of in landfills. Construction of the Birchwood Aggregate Facility was completed in March 2004. Operation startup was begun in April 2004. Plant Integration was initiated in December 2004. Integration includes mixing, extrusion, curing, crushing and screening. Lightweight aggregates with proper size gradation and bulk density were produced from the manufacturing aggregate plant and loaded on a stockpile for shipment. The shipped aggregates were used in a commercial block plant for CMU production. However, most of the production was made at low capacity factors and for a relatively short time in 2005. Several areas were identified as important factors to improve plant capacity and availability. Equipment and process control modifications and curing vessel clean up were made to improve plant operation in the first half of 2006. About 3,000 tons of crushed aggregate was produced in August 2006. UA is continuing to work to improve plant

  17. Can intra-aggregate pore structures affect the aggregate's effectiveness in protecting carbon?

    SciTech Connect

    Ananyeva, K; Wang, W; Smucker, A J.M.; Rivers, M L; Kravchenko, A N

    2012-11-15

    Aggregates are known to provide physical protection to soil organic matter shielding it from rapid decomposition. Spatial arrangement and size distribution of intra-aggregate pores play an important role in this process. This study examined relationships between intra-aggregate pores measured using X-ray computed micro-tomography images and concentrations of total C in 4–6 mm macro-aggregates from two contrasting land use and management practices, namely, conventionally tilled and managed row crop agricultural system (CT) and native succession vegetation converted from tilled agricultural land in 1989 (NS). Previous analyses of these aggregates indicated that small (<15 μm) and large (>100 μm) pores prevail in NS aggregates while medium (30–90 μm) pores are more abundant in CT aggregates (Kravchenko et al., 2011; Wang et al., 2012). We hypothesized that these differences in pore size distributions affect the ability of macro-aggregates to protect C. The results of this study supported this hypothesis. Consistent with greater heterogeneity of pore distributions within NS aggregates we observed higher total C and greater intra-aggregate C variability in NS as compared with CT aggregates. Total C concentrations and intra-aggregate C standard deviations were negatively correlated with fractions of medium sized pores, indicating that presence of such pores was associated with lower but more homogeneously distributed total C. While total C was positively correlated with presence of small and large pores. The results suggest that because of their pore structure NS macro-aggregates provide more effective physical protection to C than CT aggregates.

  18. Early College Puts Youth on a College Track

    ERIC Educational Resources Information Center

    Edmunds, Julie A.

    2016-01-01

    Early colleges are intended to serve students from populations typically underrepresented in college and to prepare those students with the academic skills and dispositions to succeed in college. Another important attribute of early colleges is that they help students earn college credit during their high school years. Many such early colleges are…

  19. Collision simulation of sintered dust aggregates

    NASA Astrophysics Data System (ADS)

    Sirono, Sin-iti; Ueno, Haruta

    Collisional evolution of dust aggregates is the initial process of the planet formation. Sticking velocity, below which collisional sticking of an aggregate happens, is a crucial quantity in the collisional evolution. In the standard model of protoplanetary nebula, the maximum collisional velocity is around 50m/s. Therefore, if a planetesimal is formed through direct collisional sticking, the sticking velocity should be higher than 50m/s. Even if a planetesimal is formed by other mechanism such as anticyclonic vortices, substantial growth of an aggregate is required because the motion of an aggregate should be decoupled from that of gas. Collisional simulation of icy dust aggregates (Wada et al. 2009, ApJ 702, 1490) showed that the sticking velocity was larger than 50m/s and planetesimal formation by collisional sticking was possible. However, sintering of ice proceeds in a wide area of a protoplanetary nebula (Sirono 2011, ApJ 765, 50). Sintering enlarges a neck, connection between adjacent dust grains, and changes the mechanical properties of a dust aggregate. Here we performed collisional simulations between sintered dust aggregates taking account of sintering. We found that the sticking velocity was decreased substantially down to 20m/s. This result suggests that a planetesimal is not formed by direct collisional sticking and that the planetesimal formation proceeded in particular regions in a protoplanetary nebula.

  20. Efficient clustering aggregation based on data fragments.

    PubMed

    Wu, Ou; Hu, Weiming; Maybank, Stephen J; Zhu, Mingliang; Li, Bing

    2012-06-01

    Clustering aggregation, known as clustering ensembles, has emerged as a powerful technique for combining different clustering results to obtain a single better clustering. Existing clustering aggregation algorithms are applied directly to data points, in what is referred to as the point-based approach. The algorithms are inefficient if the number of data points is large. We define an efficient approach for clustering aggregation based on data fragments. In this fragment-based approach, a data fragment is any subset of the data that is not split by any of the clustering results. To establish the theoretical bases of the proposed approach, we prove that clustering aggregation can be performed directly on data fragments under two widely used goodness measures for clustering aggregation taken from the literature. Three new clustering aggregation algorithms are described. The experimental results obtained using several public data sets show that the new algorithms have lower computational complexity than three well-known existing point-based clustering aggregation algorithms (Agglomerative, Furthest, and LocalSearch); nevertheless, the new algorithms do not sacrifice the accuracy. PMID:22334025

  1. A Report to the Legislature Concerning the Operation, Effect and Extent of Compliance with the Provisions of Education Code Section 84362 by California Community College Districts in Fiscal Years 1977-1978, 1978-1979 and 1979-1980.

    ERIC Educational Resources Information Center

    Nussbaum, Tom; And Others

    In response to legislative mandate, this report examines the compliance of the California community college districts with Section 84363 of the California Education Code, which requires the districts to spend 50% of their current expense of education for salaries of classroom instructors. The report first traces the legislative history of the "50%…

  2. Student Guide for Documenting Experiential Learning: Travel Agency Operation.

    ERIC Educational Resources Information Center

    Coastline Community Coll., Fountain Valley, CA.

    Coastline Community College has developed a series of guides to assist adults who wish to obtain college credit or advanced standing in evaluating and verifying their non-college learning experiences. This guide lists the competency requirements of four courses within the Travel Agency Operation program: Domestic Air Transportation; International…

  3. Seasonal variability of soil aggregate stability

    NASA Astrophysics Data System (ADS)

    Rohoskova, M.; Kodesova, R.; Jirku, V.; Zigova, A.; Kozak, J.

    2009-04-01

    Seasonal variability of soil properties measured in surface horizons of three soil types (Haplic Luvisol, Greyic Phaeozem, Haplic Cambisol) was studied in years 2007 and 2008. Undisturbed and disturbed soil samples were taken every month to evaluate field water content, bulk density, porosity, ration of gravitational and capillary pores, pHKCl and pHH2O, organic matter content and its quality, aggregate stability using WSA index. In addition, micromorphological features of soil aggregates were studied in thin soil sections that were made from undisturbed large soil aggregates. Results showed that soil aggregate stability depended on stage of the root zone development, soil management and climatic conditions. Larger aggregate stabilities and also larger ranges of measure values were obtained in the year 2007 then those measured in 2008. This was probably caused by lower precipitations and consequently lower soil water contents observed in 2007 than those measured in 2008. The highest aggregate stability was measured at the end of April in the years 2007 and 2008 in Haplic Luvisol and Greyic Phaeozem, and at the end of June in the year 2007 and at the beginning of June in 2008 in Haplic Cambisol. In all cases aggregate stability increased during the root growth and then gradually decreased due to summer rainfall events. Aggregate stability reflected aggregate structure and soil pore system development, which was documented on micromorphological images and evaluated using the ration of gravitational and capillary pores measured on the undisturbed sol samples. Acknowledgement: Authors acknowledge the financial support of the Grant Agency of the Czech Republic grant No. 526/08/0434, and the Ministry of Education, Youth and Sports grant No. MSM 6046070901.

  4. An In-Depth Study of the Four-Day College Week. Part I; The Four-Day College Week: Revolution or Evolution. Part II; A Survey of Common Practices of Texas Colleges Utilizing the Four-Day College Week.

    ERIC Educational Resources Information Center

    Riley, Bob E.

    This two-part report discusses the implementation of the four-day week on college campuses and summarizes the results of a survey conducted to investigate: (1) the history of the four-day college week in Texas; (2) how Texas colleges using this system integrate their operations into the four-day week; and (3) the future acceptance of the four-day…

  5. Generation and Exploitation of Aggregation Abstractions for Scheduling and Resource Allocation

    NASA Technical Reports Server (NTRS)

    Linden, Theodore A.; Lowry, Michael R.

    1992-01-01

    Our research is investigating abstraction of computational theories for scheduling and resource allocation. These theories are represented in a variant of first order predicate calculus, parameterized multisorted logic, that facilitates specification of large problems. A particular problem is conceptually stated as a set of ground sentences that are consistent with a quantified theory. We are mainly investigating the automated generation of aggregation abstractions and approximations in which detailed resource allocation constraints are replaced by constraints between aggregate demand and capacity. We are also investigating the interaction of aggregation abstractions with the more thoroughly investigated abstractions of weakening operator preconditions. The purpose of the theories for aggregated demand/capacity is threefold: first, to answer queries about aggregate properties, such as gross feasibility; second, to reduce computational costs by using the solution of aggregate problems to guide the solution of detailed problems; and third, to facilitate reformulating theories to approximate problems for which there are efficient problem solving methods. We also describe novel methods for exploiting aggregation abstractions.

  6. Directional sensing and streaming in Dictyostelium aggregation.

    PubMed

    Almeida, Sofia; Dilão, Rui

    2016-05-01

    We merge the Kessler-Levine simple discrete model for Dictyostelium cyclic adenosine monophosphate (cAMP) production and diffusion with the Dilão-Hauser directional sensing aggregation mechanism. The resulting compound model describes all the known transient patterns that emerge during Dictyostelium aggregation, which include the spontaneous formation of cAMP self-sustained target and spiral waves and streaming. We show that the streaming patterns depend on the speed of the amoebae, on the relaxation time for the production of cAMP, on the cAMP degradation rate, and on directional sensing. Moreover, we show that different signaling centers emerge during Dictyostelium aggregation. PMID:27300919

  7. Directional sensing and streaming in Dictyostelium aggregation

    NASA Astrophysics Data System (ADS)

    Almeida, Sofia; Dilão, Rui

    2016-05-01

    We merge the Kessler-Levine simple discrete model for Dictyostelium cyclic adenosine monophosphate (cAMP) production and diffusion with the Dilão-Hauser directional sensing aggregation mechanism. The resulting compound model describes all the known transient patterns that emerge during Dictyostelium aggregation, which include the spontaneous formation of cAMP self-sustained target and spiral waves and streaming. We show that the streaming patterns depend on the speed of the amoebae, on the relaxation time for the production of cAMP, on the cAMP degradation rate, and on directional sensing. Moreover, we show that different signaling centers emerge during Dictyostelium aggregation.

  8. A look at construction aggregates production

    USGS Publications Warehouse

    Willett, Jason Christopher

    2009-01-01

    Construction aggregates are defined as the combination of crushed stone and construction sand and gravel. Aggregates are one of the most accessible natural resources on Earth and one of the fundamental building blocks of our society. They have been used from the earliest times of our civilization for a variety of applications that have increased in number and complexity with time and technological progress. Despite the relatively low but increasing unit value of its basic products, the construction aggregates industry is a major contributor to and an indicator of the economic well-being of the nation.

  9. Exciton dynamics in perturbed vibronic molecular aggregates

    PubMed Central

    Brüning, C.; Wehner, J.; Hausner, J.; Wenzel, M.; Engel, V.

    2015-01-01

    A site specific perturbation of a photo-excited molecular aggregate can lead to a localization of excitonic energy. We investigate this localization dynamics for laser-prepared excited states. Changing the parameters of the electric field significantly influences the exciton localization which offers the possibility for a selective control of this process. This is demonstrated for aggregates possessing a single vibrational degree of freedom per monomer unit. It is shown that the effects identified for the molecular dimer can be generalized to larger aggregates with a high density of vibronic states. PMID:26798840

  10. Blood viscosity: influence of erythrocyte aggregation.

    PubMed

    Chien, S; Usami, S; Dellenback, R J; Gregersen, M I; Nanninga, L B; Guest, M M

    1967-08-18

    The addition of purified canine or bovine fibrinogen to suspensions of canine erythocytes in Ringer solution caused an increase in viscosity and the formation of aggregates of erythocytes. Both of these effects became increasingly pronounced as the fibrinogen concentration was raised, and they approached plateaus with 1 gram of fibrinogen per 100 milliliters. An increase in shear rate (or shear stress) reduced both the effect on viscosity and the aggregate size. The data suggest that fibrinogen causes an increase in blood viscosity and a departure from Newtonian behavior by interacting with erythrocytes to form cell aggregates which can be dispersed by shear stress. PMID:17842794

  11. Directional sensing and streaming in Dictyostelium aggregation.

    PubMed

    Almeida, Sofia; Dilão, Rui

    2016-05-01

    We merge the Kessler-Levine simple discrete model for Dictyostelium cyclic adenosine monophosphate (cAMP) production and diffusion with the Dilão-Hauser directional sensing aggregation mechanism. The resulting compound model describes all the known transient patterns that emerge during Dictyostelium aggregation, which include the spontaneous formation of cAMP self-sustained target and spiral waves and streaming. We show that the streaming patterns depend on the speed of the amoebae, on the relaxation time for the production of cAMP, on the cAMP degradation rate, and on directional sensing. Moreover, we show that different signaling centers emerge during Dictyostelium aggregation.

  12. Aggregation of ice crystals in cirrus

    NASA Technical Reports Server (NTRS)

    Kajikawa, Masahiro; Heymsfield, Andrew J.

    1989-01-01

    Results are given from analysis of the aggregation of thick plate, columnar, and bullet rosette ice crystals in cirrus. Data were obtained from PMS 2D-C images, oil coated slides, and aircraft meteorological measurements. Crystal size ranged from 100 to 900 microns in temperatures from -30 to -45 C. The results indicate that the ratio of the sizes of aggregating crystals and the difference of their terminal velocities are important in aggregation. The collection efficiency was calculated for the thick plate crystals from the same data.

  13. Metal concentrations in aggregate interiors, exteriors, whole aggregates, and bulk of Costa Rican soils

    SciTech Connect

    Wilcke, W.; Kretzschmar, S.; Bundt, M.; Zech, W.

    1999-10-01

    In many temperate soils the preferential weathering and leaching of aggregate surfaces and the nonaggregated material between aggregates depletes geogenic metals. It also shifts metals from strongly to more weakly bound metal forms. Deposited metals are sorbed preferentially on aggregate surfaces and between aggregates. The authors examined whether preferential desilication under tropical climate causes an enrichment in the aggregate exteriors in oxidic forms of metals. They also studied where deposited metals are bound in these soils. Aggregates (2--20 mm) were selected manually from the A horizons of eight Oxisols, six Andisols, two Mollisols, and two Inceptisols in Costa Rica. All samples were fractionated into interior and exterior portions and treated with a seven-step sequence to extract Al, Cd, Cu, Fe, Mn, Pb, and Zn. Total concentrations of all metals except Zn were higher in the aggregate exteriors than in the interiors. The average Cd and Pb concentrations in easily extractable fractions were significantly higher in the aggregate exteriors. There were no significant differences in metal partitioning between interiors and exteriors except for Pb, which had higher proportions in extractable forms with NH{sub 2}OH {center{underscore}dot} HCl {gt} NH{sub 4} - acetate, pH 6.0 {gt} EDTA in the exteriors. There were few significant differences in metal concentrations and partitioning between bulk soil and whole aggregates. The results may be explained by (i) preferential desilication of the aggregate exteriors and (ii) preferential sorption of deposited heavy metals mainly in easily extractable forms.

  14. Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations.

    PubMed

    Barnett, Gregory V; Qi, Wei; Amin, Samiul; Neil Lewis, E; Roberts, Christopher J

    2015-12-01

    Non-native aggregation is a common issue in a number of degenerative diseases and during manufacturing of protein-based therapeutics. There is a growing interest to monitor protein stability at intermediate to high protein concentrations, which are required for therapeutic dosing of subcutaneous injections. An understanding of the impact of protein structural changes and interactions on the protein aggregation mechanisms and resulting aggregate size and morphology may lead to improved strategies to reduce aggregation and solution viscosity. This report investigates non-native aggregation of a model protein, α-chymotrypsinogen, under accelerated conditions at elevated protein concentrations. Far-UV circular dichroism and Raman scattering show structural changes during aggregation. Size exclusion chromatography and laser light scattering are used to monitor the progression of aggregate growth and monomer loss. Monomer loss is concomitant with increased β-sheet structures as monomers are added to aggregates, which illustrate a transition from a native monomeric state to an aggregate state. Aggregates grow predominantly through monomer-addition, resulting in a semi-flexible polymer morphology. Analysis of aggregation growth kinetics shows that pH strongly affects the characteristic timescales for nucleation (τn) and growth (τg), while the initial protein concentration has only minor effects on τn or τg. Low-shear viscosity measurements follow a common scaling relationship between average aggregate molecular weight (Mw(agg)) and concentration (σ), which is consistent with semi-dilute polymer-solution theory. The results establish a link between aggregate growth mechanisms, which couple Mw(agg) and σ, to increases in solution viscosity even at these intermediate protein concentrations (less than 3w/v %).

  15. Junk-Bond Colleges.

    ERIC Educational Resources Information Center

    Van Der Werf, Martin

    2003-01-01

    Describes how a long-predicted decline in the fortunes of small private colleges is beginning to show up in the bond market, as the number of colleges now rated in the junk category has nearly doubled. (EV)

  16. Coping with College Stress

    MedlinePlus

    ... gov/news/fullstory_160792.html Coping With College Stress Parents can help make the transition easier for ... 5, 2016 MONDAY, Sept. 5, 2016 (HealthDay News) -- Stress and anxiety are common among new college students, ...

  17. Scalable and fault tolerant orthogonalization based on randomized distributed data aggregation

    PubMed Central

    Gansterer, Wilfried N.; Niederbrucker, Gerhard; Straková, Hana; Schulze Grotthoff, Stefan

    2013-01-01

    The construction of distributed algorithms for matrix computations built on top of distributed data aggregation algorithms with randomized communication schedules is investigated. For this purpose, a new aggregation algorithm for summing or averaging distributed values, the push-flow algorithm, is developed, which achieves superior resilience properties with respect to failures compared to existing aggregation methods. It is illustrated that on a hypercube topology it asymptotically requires the same number of iterations as the optimal all-to-all reduction operation and that it scales well with the number of nodes. Orthogonalization is studied as a prototypical matrix computation task. A new fault tolerant distributed orthogonalization method rdmGS, which can produce accurate results even in the presence of node failures, is built on top of distributed data aggregation algorithms. PMID:24748902

  18. Network Intrusion Detection and Visualization using Aggregations in a Cyber Security Data Warehouse

    SciTech Connect

    Czejdo, Bogdan; Ferragut, Erik M; Goodall, John R; Laska, Jason A

    2012-01-01

    The challenge of achieving situational understanding is a limiting factor in effective, timely, and adaptive cyber-security analysis. Anomaly detection fills a critical role in network assessment and trend analysis, both of which underlie the establishment of comprehensive situational understanding. To that end, we propose a cyber security data warehouse implemented as a hierarchical graph of aggregations that captures anomalies at multiple scales. Each node of our pro-posed graph is a summarization table of cyber event aggregations, and the edges are aggregation operators. The cyber security data warehouse enables domain experts to quickly traverse a multi-scale aggregation space systematically. We describe the architecture of a test bed system and a summary of results on the IEEE VAST 2012 Cyber Forensics data.

  19. Nanoscale Ionic Aggregate Morphology in Zwitterionic Copolymers

    NASA Astrophysics Data System (ADS)

    Choi, Jae-Hong; Huyck, Rebecca; Salas-de La Cruz, David; Long, Timothy E.; Winey, Karen I.

    2009-03-01

    The morphology of two different zwitterionic copolymers, poly(sulfobetaine methacrylate-ran-butyl acrylate), and poly(sulfobetaine methacrylamide-ran-butyl acrylate) are investigated as a function of the mol % content of SBMA (7 and 9 mol %) and SBMAm (6, 10 and 13 mol %), respectively. In both copolymers, X-ray scattering results show a new structure in the material arising from ionic aggregates. The sizes of the ionic aggregates are obtained through the scattering model. The sizes of the ionic aggregates increase as the ion content increases. The application of scanning transmission electron microscopy to the study of ionomer morphology has enabled direct, model-independent visualization of the ionic aggregates. The correlation between X-ray scattering results and the real space imaging for morphology of these zwitterionic copolymers will be presented.

  20. 31 CFR 1023.313 - Aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR BROKERS OR DEALERS IN SECURITIES Reports Required To Be Made By Brokers or Dealers in Securities § 1023.313 Aggregation. Refer to § 1010.313 of this... securities....

  1. Diffusion-limited aggregation on curved surfaces

    NASA Astrophysics Data System (ADS)

    Choi, J.; Crowdy, D.; Bazant, M. Z.

    2010-08-01

    We develop a general theory of transport-limited aggregation phenomena occurring on curved surfaces, based on stochastic iterated conformal maps and conformal projections to the complex plane. To illustrate the theory, we use stereographic projections to simulate diffusion-limited aggregation (DLA) on surfaces of constant Gaussian curvature, including the sphere (K>0) and the pseudo-sphere (K<0), which approximate "bumps" and "saddles" in smooth surfaces, respectively. Although the curvature affects the global morphology of the aggregates, the fractal dimension (in the curved metric) is remarkably insensitive to curvature, as long as the particle size is much smaller than the radius of curvature. We conjecture that all aggregates grown by conformally invariant transport on curved surfaces have the same fractal dimension as DLA in the plane. Our simulations suggest, however, that the multifractal dimensions increase from hyperbolic (K<0) to elliptic (K>0) geometry, which we attribute to curvature-dependent screening of tip branching.

  2. Silt-clay aggregates on Mars

    NASA Technical Reports Server (NTRS)

    Greeley, R.

    1979-01-01

    Viking observations suggest abundant silt and clay particles on Mars. It is proposed that some of these particles agglomerate to form sand size aggregates that are redeposited as sandlike features such as drifts and dunes. Although the binding for the aggregates could include salt cementation or other mechanisms, electrostatic bonding is considered to be a primary force holding the aggregates together. Various laboratory experiments conducted since the 19th century, and as reported here for simulated Martian conditions, show that both the magnitude and sign of electrical charges on windblown particles are functions of particle velocity, shape and composition, atmospheric pressure, atmospheric composition and other factors. Electrical charges have been measured for saltating particles in the wind tunnel and in the field, on the surfaces of sand dunes, and within dust clouds on earth. Similar, and perhaps even greater, charges are proposed to occur on Mars, which could form aggregates of silt and clay size particles

  3. Active matter model of Myxococcus xanthus aggregation

    NASA Astrophysics Data System (ADS)

    Patch, Adam; Bahar, Fatmagul; Liu, Guannan; Thutupalli, Shashi; Welch, Roy; Yllanes, David; Shaevitz, Joshua; Marchetti, M. Cristina

    Myxococcus xanthus is a soil-dwelling bacterium that exhibits several fascinating collective behaviors including streaming, swarming, and generation of fruiting bodies. A striking feature of M. xanthus is that it periodically reverses its motility direction. The first stage of fruiting body formation is characterized by the aggregation of cells on a surface into round mesoscopic structures. Experiments have shown that this aggregation relies heavily on regulation of the reversal rate and local mechanical interactions, suggesting motility-induced phase separation may play an important role. We have adapted self-propelled particle models to include cell reversal and motility suppression resulting from sporulation observed in aggregates. Using 2D molecular dynamics simulations, we map the phase behavior in the space of Péclet number and local density and examine the kinetics of aggregation for comparison to experiments.

  4. Anger expression correlates with platelet aggregation.

    PubMed

    Wenneberg, S R; Schneider, R H; Walton, K G; MacLean, C R; Levitsky, D K; Mandarino, J V; Waziri, R; Wallace, R K

    1997-01-01

    Potential relationships between increased platelet aggregability and such psychological characteristics as hostility and anger were investigated as part of a larger intervention study investigating the potential efficacy of stress-reduction treatments. Participants performed 6-minute mental arithmetic tests under time pressure. Blood was sampled during the first minute of the task and whole blood platelet aggregation was measured in an aggregometer, using collagen and ADP. To assess anger and hostility, the authors used Spielberger's State-Trait Anger and Anger Expression scales together with the Cook-Medley Hostility Scale. The authors found positive correlations between collagen-induced platelet aggregation and outwardly expressed anger, as measured by the Anger Expression Scale. The findings suggested that modes of anger expression may be associated with increased platelet aggregation. If confirmed by future studies, this finding could provide a mechanism for the putative connection between anger/hostility and coronary heart disease.

  5. Acid soluble, pepsin resistant platelet aggregating material

    SciTech Connect

    Schneider, M.D.

    1982-08-31

    Disclosed is an acid soluble, pepsin resistant, platelet aggregating material isolated from equine arterial tissue by extraction with dilute aqueous acid. The method of isolation and use to control bleeding are described. 4 figs.

  6. Blue-emitting pyrene-based aggregates.

    PubMed

    Valera, Jorge S; Calbo, Joaquín; Gómez, Rafael; Ortí, Enrique; Sánchez, Luis

    2015-06-25

    The supramolecular polymerization of pyrene imidazoles 1 and 2, governed by H-bonding and C-H···π interactions, yields aggregates showing the characteristic bluish emission pattern of pyrene-based monomers.

  7. Quicklime application instantly increases soil aggregate stability

    NASA Astrophysics Data System (ADS)

    Keiblinger, Katharina M.; Bauer, Lisa M.; Deltedesco, Evi; Holawe, Franz; Unterfrauner, Hans; Zehetner, Franz; Peticzka, Robert

    2016-01-01

    Agricultural intensification, especially enhanced mechanisation of soil management, can lead to the deterioration of soil structure and to compaction. A possible amelioration strategy is the application of (structural) lime. In this study, we tested the effect of two different liming materials, ie limestone (CaCO3) and quicklime (CaO), on soil aggregate stability in a 3-month greenhouse pot experiment with three agricultural soils. The liming materials were applied in the form of pulverised additives at a rate of 2 000 kg ha-1. Our results show a significant and instantaneous increase of stable aggregates after quicklime application whereas no effects were observed for limestone. Quicklime application seems to improve aggregate stability more efficiently in soils with high clay content and cation exchange capacity. In conclusion, quicklime application may be a feasible strategy for rapid improvement of aggregate stability of fine textured agricultural soils.

  8. College Transition Programs for Community College Students

    ERIC Educational Resources Information Center

    Haugen, Douglas E.

    2012-01-01

    Over the past four decades the number of students enrolling in colleges and universities requiring at least one pre-college level course has been about one-third of all students. Underprepared students are as likely to complete their academic goals as their prepared counterparts if they are able to complete their remedial course work. This study…

  9. College Affordability: Implications for College Opportunity

    ERIC Educational Resources Information Center

    Perna, Laura W.; Li, Chunyan

    2006-01-01

    By examining trends in college affordability, this article explores the extent to which the public perception that college is not affordable is justified. First, the article describes trends in national indicators that contribute to ability to pay, including income growth, health care costs, debt burden, and personal savings rates. Trends in…

  10. All-College Council at Maryville College.

    ERIC Educational Resources Information Center

    Blair, Carolyn L.

    In May 1968, the Special Committee on Community Life and Structure of Maryville College recommended that an All-College Council be organized by January 1969. Following approval of this recommendation by the Executive Council of the Faculty, the Special Committee proposed the nomination of 15 council members who were subsequently chosen in a…

  11. College Turnaround: Guidance on Colleges in Recovery.

    ERIC Educational Resources Information Center

    Atkinson, David

    This document is intended to assist senior managers and governors of colleges in the United Kingdom that are faced with serious difficulties. The first section provides an overview of how the issues of college recovery were handled under the Further Education Funding Council. The second section examines crisis and recovery in corporations and…

  12. Brain tumor segmentation in MRI based on fuzzy aggregators

    NASA Astrophysics Data System (ADS)

    Zhu, Yan; Liao, Qingmin; Dou, Weibei; Ruan, Su

    2005-07-01

    Magnetic Resonance Image (MRI) is widely used in radiology diagnosis, especially in pathology detection in human brain. Most of the methods now applied to automatically segment brain tumors rely on T1-weighted sequences exclusively despite the fact that the imaging agent is multi-spectral. The work focuses on the integration or fusion of information provided by each sequence, i.e. T1, T2 and PD. Based on the fuzzy aggregators proposed in fuzzy theory, a system integrating all these information is established. The paper discusses some famous operators, their properties and application in tumor segmentation. In particular, Davies-Bouldin index is used to determine the parameters of the parametric operations. The result shows the importance of data fusion in segmentation process, discovers that T-norms are less robust to noise compared with mean operators. Meanwhile, weights allocated illustrate the order of importance of each spectrum in pathology detection, and are in agreement with their characteristic.

  13. Implementing College Strategic Plans.

    ERIC Educational Resources Information Center

    Further Education Development Agency, London (England).

    This document, which is intended for individuals responsible for planning and management at further education (FE) colleges, summarizes the factors that contributed to or obstructed implementation of strategic plans in 10 FE colleges in England and Wales in 1994-95. It presents key questions and illustrations that FE colleges can use for…

  14. Financing Community Colleges, 1978.

    ERIC Educational Resources Information Center

    Wattenbarger, James L.; Stepp, William F.

    The fourth in a series of analytical studies of the financing of community colleges in the United States, this report provides information for the 38 states which accounted for more than 95% of the total Fall 1978 community college enrollment. Data indicate that allocation of funds to community colleges still follows four traditional patterns and…

  15. Community Colleges in Canada.

    ERIC Educational Resources Information Center

    Campbell, Gordon

    This book includes a comprehensive directory of all community colleges and related institutions in Canada as well as a discussion of the history and development of th community college movement in Canada. Data are based on community college presidents' responses to mailed questionnaires, unstructured interviews, and press clippings pertaining to…

  16. Establishing American Colleges Abroad.

    ERIC Educational Resources Information Center

    Greene, William E.

    1990-01-01

    Describes the growing involvement of U.S. two-year colleges in establishing programs abroad to enable foreign students to complete one or two years of college-level work in their home country before transferring to U.S. universities. Highlights the activities of several community colleges in the Pacific Rim. Identifies conditions basic to future…

  17. A COLLEGE HEALTH CENTER.

    ERIC Educational Resources Information Center

    BRAD, BERNARD

    THIS REPORT CONSIDERS PROBLEMS AND SOLUTIONS RELATED TO THE DESIGN AND ESTABLISHMENT OF COLLEGE HEALTH FACILITIES. THIS INCLUDES THE RESULTS OF A STUDY INVOLVING COLORADO, KNOX, AND WITTENBERG COLLEGES IN WHICH PERSONAL VISITS AND EXPERT TESTIMONY CONCLUDED THAT THE HEALTH SERVICES OF SMALL COLLEGES IN THE CENTRAL AND WESTERN STATES WERE SERIOUSLY…

  18. A College Health Center.

    ERIC Educational Resources Information Center

    Bard, Bernard

    This report considers problems and solutions related to the design and establishment of college health facilities. This includes the results of a study involving Colorado, Knox, and Wittenberg Colleges in which personal visits and expert testimony concluded that the health services of small colleges in the central and western states were seriously…

  19. Paradise Valley Community College

    ERIC Educational Resources Information Center

    Dale, Paul A.

    2009-01-01

    Paradise Valley Community College (PVCC), located in Phoenix, Arizona, is part of the Maricopa County Community College District (MCCCD). PVCC was founded in 1987 and in the fall of 2007 served 8,739 students in credit courses. Since 1997, PVCC has been on a quest to become a "more learning centered" college. As a result of placing student…

  20. Prometheus College Bound.

    ERIC Educational Resources Information Center

    Austell, David B., Jr.

    1986-01-01

    Reports on interviews conducted to assess the status of humanities instruction in North Carolina's community colleges. Includes Dallas Herring's reflections on the establishment and growth of the state's community college system. Summarizes interviews with central office representatives and two-year college managers concerning the mission and…

  1. Early College High Schools

    ERIC Educational Resources Information Center

    Dessoff, Alan

    2011-01-01

    For at-risk students who stand little chance of going to college, or even finishing high school, a growing number of districts have found a solution: Give them an early start in college while they still are in high school. The early college high school (ECHS) movement that began with funding from the Bill and Melinda Gates Foundation 10 years ago…

  2. Special Report: College Housing.

    ERIC Educational Resources Information Center

    Abramson, Paul

    2003-01-01

    Responses of chief housing officers of 118 4-year colleges and universities to a survey focusing on costs, security, policies, and preferences provide a picture of college housing. More than 67% of respondents say that their colleges are planning to build more residential space. (SLD)

  3. What Is College for?

    ERIC Educational Resources Information Center

    Delbanco, Andrew

    2012-01-01

    What is college for? There are basically three prevailing answers to this question. The most common answer is an economic one, though it is really two linked answers: first, that providing more people with a college education is good for the economic health of the nation; and second, that going to college is good for the economic competitiveness…

  4. College Access Marketing

    ERIC Educational Resources Information Center

    Tremblay, Christopher W.

    2011-01-01

    College Access Marketing (CAM) is a relatively new phenomenon that seeks to positively influence the college-going rate. This report defines CAM, describes CAM examples, and discusses how CAM seeks to counter barriers to college. It explores four main elements of CAM: information, marketing, advocacy, and social mobilization. Further, it…

  5. Leasing the College Store.

    ERIC Educational Resources Information Center

    Scott, Richard M.

    1986-01-01

    A survey of college administrators responsible for supervising college stores found that three factors are strongly considered in deciding whether to lease the college store: available management skills, service orientation, and financial resources. It also found that private and public institutions and large and small institutions rank the…

  6. Can Colleges Really Collaborate?

    ERIC Educational Resources Information Center

    Welch, Edwin H.

    2008-01-01

    Seven small private colleges in three states have found a way to reduce their administrative technology costs and expand their technological capability at the same time. They have done it by choosing the common-sense, yet unconventional, college and university strategy of genuine collaboration. The result, the Independent College Enterprise (ICE),…

  7. The College Promise

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2009-01-01

    College fees and tuition are rising--430 percent since 1982. Student borrowing for college has more than doubled since 1998, and about 50 percent of lower-income students head to college following high school, compared to 80 percent of high-income students, according to the National Center for Education Statistics. Various public school districts…

  8. Ion-specific aggregation of hydrophobic particles.

    PubMed

    López-León, Teresa; Ortega-Vinuesa, Juan Luis; Bastos-González, Delfina

    2012-06-18

    This work shows that colloidal stability and aggregation kinetics of hydrophobic polystyrene (PS) nanospheres are extremely sensitive to the nature of the salt used to coagulate them. Three PS latices and four aggregating electrolytes, which all share the same cation (Na(+)) but have various anions located at different positions in the classical Hofmeister series depending on their kosmotropic or chaotropic character, are used. The present study focuses on analyzing different aggregating parameters, such as critical coagulation concentrations (CCC), cluster size distributions (CSD), initial kinetic constants K(11), and fractal dimensions of the aggregates d(f). While aggregation induced by SO(4)(2-) and Cl(-) behaved according to the predictions of the classical Derjaguin-Landau-Verwey-Overbeek theory, important discrepancies are found with NO(3)(-), which become dramatic when using SCN(-). These discrepancies among the anions were far more significant when they acted as counterions rather than as co-ions. While SO(4)(2-) and Cl(-) trigger fast diffusion-limited aggregation, SCN(-) gives rise to a stationary cluster size distribution in a few aggregation times when working with cationic PS particles. Clear differences are found among all analyzed parameters (CCC, CSD, K(11), and d(f)), and the experimental findings show that particles aggregate in potential wells whose depth is controlled by the chaotropic character of the anion. This paper presents new experimental evidence that may help to understand the microscopic origin of Hofmeister effects, as the observations are consistent with appealing theoretical models developed in the last few years. PMID:22556130

  9. Low aggregation state diminishes ferrihydrite reactivity

    NASA Astrophysics Data System (ADS)

    Braunschweig, Juliane; Heister, Katja; Meckenstock, Rainer U.

    2013-04-01

    Ferrihydrite is an abundant iron(oxy)hydroxide in soils and sediments and plays an important role in microbial iron cycling due to its high reactivity. Therefore, it is often synthesized and used in geomicrobiological and mineralogical studies. The reactivities of synthetic ferrihydrites vary between different studies and synthesis protocols. Hence, we synthesized five different ferrihydrites and characterized them with XRD, FTIR, XPS, and BET specific surface area. The reactivity of the ferrihydrite samples towards ascorbic acid was examined and compared with microbial reduction rates by Geobacter sulfurreducens. FTIR and XRD results show the presence of secondary, higher crystalline iron oxide phases like goethite and akaganeite for two samples. Consequently, those samples revealed lower biotic and abiotic reduction rates compared to pure ferrihydrite. Comparison of reduction rates with the specific surface area of all ferrihydrites showed neither correlation with abiotic reductive dissolution nor with microbial reduction. Especially one sample, characterized by a very low aggregation state and presence of secondary minerals, revealed a poor reactivity. We speculate that apart from the occurring secondary minerals also the low aggregation state played an important role. Decreasing aggregation diminishes the amount of kinks and edges on the surfaces, which are produced at contact sites in aggregates. According to dissolution theories, dissolution mainly starts at those surface defects and slows down with decreasing amount of defects. Furthermore, the non-aggregated ferrihydrite is free of micropores, a further stimulant for dissolution. Independent repetitions of experiments and syntheses according to the same protocol but without formation of secondary minerals, confirmed the low reactivity of the non-aggregated ferrihydrite. In summary, our results indicate that a decreasing aggregation state of ferrihydrite to a certain size does increase the reactivity

  10. Modeling Protein Aggregate Assembly and Structure

    NASA Astrophysics Data System (ADS)

    Guo, Jun-tao; Hall, Carol K.; Xu, Ying; Wetzel, Ronald

    One might say that "protein science" got its start in the domestic arts, built around the abilities of proteins to aggregate in response to environmental stresses such as heating (boiled eggs), heating and cooling (gelatin), and pH (cheese). Characterization of proteins in the late nineteenth century likewise focused on the ability of proteins to precipitate in response to certain salts and to aggregate in response to heating. Investigations by Chick and Martin (Chick and Martin, 1910) showed that the inactivating response of proteins to heat or solvent treatment is a two-step process involving separate denaturation and precipitation steps. Monitoring the coagulation and flocculation responses of proteins to heat and other stresses remained a major approach to understanding protein structure for decades, with solubility, or susceptibility to aggregation, serving as a kind of benchmark against which results of other methods, such as viscosity, chemical susceptibility, immune activity, crystallizability, and susceptibility to proteolysis, were compared (Mirsky and Pauling, 1936;Wu, 1931). Toward the middle of the last century, protein aggregation studies were largely left behind, as improved methods allowed elucidation of the primary sequence of proteins, reversible unfolding studies, and ultimately high-resolution structures. Curiously, the field of protein science, and in particular protein folding, is now gravitating back to a closer look at protein aggregation and protein aggregates. Unfortunately, the means developed during the second half of the twentieth century for studying native, globular proteins have not proved immediately amenable to the study of aggregate structures. Great progress is being made, however, to modify classical methods, including NMR and X-ray diffraction, as well as to develop newer techniques, that together should continue to expand our picture of aggregate structure (Kheterpal and Wetzel, 2006; Wetzel, 1999).

  11. Identification of aggregates for Tennessee bituminous surface courses

    NASA Astrophysics Data System (ADS)

    Sauter, Heather Jean

    Tennessee road construction is a major venue for federal and state spending. Tax dollars each year go to the maintenance and construction of roads. One aspect of highway construction that affects the public is the safety of its state roads. There are many factors that affect the safety of a given road. One factor that was focused on in this research was the polish resistance capabilities of aggregates. Several pre-evaluation methods have been used in the laboratory to predict what will happen in a field situation. A new pre-evaluation method was invented that utilized AASHTO T 304 procedure upscaled to accommodate surface bituminous aggregates. This new method, called the Tennessee Terminal Textural Condition Method (T3CM), was approved by Tennessee Department of Transportation to be used as a pre-evaluation method on bituminous surface courses. It was proven to be operator insensitive, repeatable, and an accurate indication of particle shape and texture. Further research was needed to correlate pre-evaluation methods to the current field method, ASTM E 274-85 Locked Wheel Skid Trailer. In this research, twenty-five in-place bituminous projects and eight source evaluations were investigated. The information gathered would further validate the T3CM and find the pre-evaluation method that best predicted the field method. In addition, new sources of aggregates for bituminous surface courses were revealed. The results of this research have shown T3CM to be highly repeatable with an overall coefficient of variation of 0.26% for an eight sample repeatability test. It was the best correlated pre-evaluation method with the locked wheel skid trailer method giving an R2 value of 0.3946 and a Pearson coefficient of 0.710. Being able to predict field performance of aggregates prior to construction is a powerful tool capable of saving time, money, labor, and possibly lives.

  12. Protein sequences encode safeguards against aggregation.

    PubMed

    Reumers, Joke; Maurer-Stroh, Sebastian; Schymkowitz, Joost; Rousseau, Fréderic

    2009-03-01

    Functional requirements shaped proteins into globular structures. Under these structural constraints, which require both regular secondary structure and a hydrophobic core, protein aggregation is an unavoidable corollary to protein structure. However, as aggregation results in reduced fitness, natural selection will tend to eliminate strongly aggregating sequences. The analysis of distribution and variation of aggregation patterns in the human proteome using the TANGO algorithm confirms the findings of a previous study on several proteomes: the flanks of aggregation-prone regions are enriched with charged residues and proline, the so-called gatekeeper-residues. Moreover, in this study, we observed a widespread redundancy in gatekeeper usage. Interestingly, aggregating regions from key proteins such as p53 or huntingtin are among the most extensive "gatekept" sequences. As a consequence, mutations that remove gatekeepers could therefore result in a strong increase in disease-susceptibility. In a set of disease-associated mutations from the UniProt database, we find a strong enrichment of mutations that disrupt gatekeeper motifs. Closer inspection of a number of case studies indicates clearly that removing gatekeepers may play a determining role in widely varying disorders, such as van der Woude syndrome (VWS), X-linked Fabry disease (FD), and limb-girdle muscular dystrophy. PMID:19156839

  13. Growth hormone aggregates in the rat adenohypophysis

    NASA Technical Reports Server (NTRS)

    Farrington, M.; Hymer, W. C.

    1990-01-01

    Although it has been known for some time that GH aggregates are contained within the rat anterior pituitary gland, the role that they might play in pituitary function is unknown. The present study examines this issue using the technique of Western blotting, which permitted visualization of 11 GH variants with apparent mol wt ranging from 14-88K. Electroelution of the higher mol wt variants from gels followed by their chemical reduction with beta-mercaptoethanol increased GH immunoassayability by about 5-fold. With the blot procedure we found 1) that GH aggregates greater than 44K were associated with a 40,000 x g sedimentable fraction; 2) that GH aggregates were not present in glands from thyroidectomized rats, but were in glands from the thyroidectomized rats injected with T4; 3) that GH aggregates were uniquely associated with a heavily granulated somatotroph subpopulation isolated by density gradient centrifugation; and 4) that high mol wt GH forms were released from the dense somatotrophs in culture, since treatment of the culture medium with beta-mercaptoethanol increased GH immunoassayability by about 5-fold. Taken together, the results show that high mol wt GH aggregates are contained in secretory granules of certain somatotrophs and are also released in aggregate form from these cells in vitro.

  14. Simulations of kinetically irreversible protein aggregate structure.

    PubMed Central

    Patro, S Y; Przybycien, T M

    1994-01-01

    We have simulated the structure of kinetically irreversible protein aggregates in two-dimensional space using a lattice-based Monte-Carlo routine. Our model specifically accounts for the intermolecular interactions between hydrophobic and hydrophilic protein surfaces and a polar solvent. The simulations provide information about the aggregate density, the types of inter-monomer contacts and solvent content within the aggregates, the type and extent of solvent exposed perimeter, and the short- and long-range order all as a function of (i) the extent of monomer hydrophobic surface area and its distribution on the model protein surface and (ii) the magnitude of the hydrophobic-hydrophobic contact energy. An increase in the extent of monomer hydrophobic surface area resulted in increased aggregate densities with concomitant decreased system free energies. These effects are accompanied by increases in the number of hydrophobic-hydrophobic contacts and decreases in the solvent-exposed hydrophobic surface area of the aggregates. Grouping monomer hydrophobic surfaces in a single contiguous stretch resulted in lower aggregate densities and lower short range order. More favorable hydrophobic-hydrophobic contact energies produced structures with higher densities but the number of unfavorable protein-protein contacts was also observed to increase; greater configurational entropy produced the opposite effect. Properties predicted by our model are in good qualitative agreement with available experimental observations. Images FIGURE 6 FIGURE 13 PMID:8061184

  15. An energy landscape approach to protein aggregation

    NASA Astrophysics Data System (ADS)

    Buell, Alexander; Knowles, Tuomas

    2012-02-01

    Protein aggregation into ordered fibrillar structures is the hallmark of a class of diseases, the most prominent examples of which are Alzheimer's and Parkinson's disease. Recent results (e.g. Baldwin et al. J. Am. Chem. Soc. 2011) suggest that the aggregated state of a protein is in many cases thermodynamically more stable than the soluble state. Therefore the solubility of proteins in a cellular context appears to be to a large extent under kinetic control. Here, we first present a conceptual framework for the description of protein aggregation ( see AK Buell et al., Phys. Rev. Lett. 2010) that is an extension to the generally accepted energy landscape model for protein folding. Then we apply this model to analyse and interpret a large set of experimental data on the kinetics of protein aggregation, acquired mainly with a novel biosensing approach (see TPJK Knowles et al, Proc. Nat. Acad. Sc. 2007). We show how for example the effect of sequence modifications on the kinetics and thermodynamics of human lysozyme aggregation can be understood and quantified (see AK Buell et al., J. Am. Chem. Soc. 2011). These results have important implications for therapeutic strategies against protein aggregation disorders, in this case lysozyme systemic amyloidosis.

  16. Influence of Phenylalanine on Carotenoid Aggregation

    NASA Astrophysics Data System (ADS)

    Lu, L.; Ni, X.; Luo, X.

    2015-01-01

    The carotenoids lutein and β-carotene form, in 1:1 ethanol-water mixtures H-aggregates, of different strengths. The effects of phenylalanine on these aggregates were recorded by UV-Vis absorption, steady-state fluorescence, and Raman spectra. The H-aggregate of lutein was characterized by a large 78 nm blue shift in the absorption spectra, confirming the strong coupling between hydroxyl groups of adjacent molecules. The 15 nm blue shift in the β-carotene mixture also indicates that it was assembled by weak coupling between polyenes. After adding phenylalanine, the reducing absorption strength of the aggregates of lutein and reappearance of vibrational substructure indicate that the hydroxyl and amino groups of phenylalanine may coordinate to lutein and disaggregate the H-aggregates. However, phenylalanine had no effect on aggregates of β-carotene. The Raman spectra show three bands of carotenoids whose intensities decreased with increasing phenylalanine concentration. The frequency of ν1 corresponding to the length of the conjugated region was more sensitive to the solution of lutein. This coordination of phenylalanine to lutein could increase the length of the conjugated region. In addition, phenylalanine significantly affected the excited electronic states of carotenoids, which were crucial in the energy transfer from carotenoids to chlorophyll a in vivo.

  17. Proline inhibits aggregation during protein refolding.

    PubMed Central

    Samuel, D.; Kumar, T. K.; Ganesh, G.; Jayaraman, G.; Yang, P. W.; Chang, M. M.; Trivedi, V. D.; Wang, S. L.; Hwang, K. C.; Chang, D. K.; Yu, C.

    2000-01-01

    The in vitro refolding of hen egg-white lysozyme is studied in the presence of various osmolytes. Proline is found to prevent aggregation during protein refolding. However, other osmolytes used in this study fail to exhibit a similar property. Experimental evidence suggests that proline inhibits protein aggregation by binding to folding intermediate(s) and trapping the folding intermediate(s) into enzymatically inactive, "aggregation-insensitive" state(s). However, elimination of proline from the refolded protein mixture results in significant recovery of the bacteriolytic activity. At higher concentrations (>1.5 M), proline is shown to form loose, higher-order molecular aggregate(s). The supramolecular assembly of proline is found to possess an amphipathic character. Formation of higher-order aggregates is believed to be crucial for proline to function as a protein folding aid. In addition to its role in osmoregulation under water stress conditions, the results of this study hint at the possibility of proline behaving as a protein folding chaperone. PMID:10716186

  18. Effects of tau domain-specific antibodies and intravenous immunoglobulin on tau aggregation and aggregate degradation.

    PubMed

    Esteves-Villanueva, Jose O; Trzeciakiewicz, Hanna; Loeffler, David A; Martić, Sanela

    2015-01-20

    Tau pathology, including neurofibrillary tangles, develops in Alzheimer's disease (AD). The aggregation and hyperphosphorylation of tau are potential therapeutic targets for AD. Administration of anti-tau antibodies reduces tau pathology in transgenic "tauopathy" mice; however, the optimal tau epitopes and conformations to target are unclear. Also unknown is whether intravenous immunoglobulin (IVIG) products, currently being evaluated in AD trials, exert effects on pathological tau. This study examined the effects of anti-tau antibodies targeting different tau epitopes and the IVIG Gammagard on tau aggregation and preformed tau aggregates. Tau aggregation was assessed by transmission electron microscopy and fluorescence spectroscopy, and the binding affinity of the anti-tau antibodies for tau was evaluated by enzyme-linked immunosorbent assays. Antibodies used were anti-tau 1-150 ("D-8"), anti-tau 259-266 ("Paired-262"), anti-tau 341-360 ("A-10"), and anti-tau 404-441 ("Tau-46"), which bind to tau's N-terminus, microtubule binding domain (MBD) repeat sequences R1 and R4, and the C-terminus, respectively. The antibodies Paired-262 and A-10, but not D-8 and Tau-46, reduced tau fibrillization and degraded preformed tau aggregates, whereas the IVIG reduced tau aggregation but did not alter preformed aggregates. The binding affinities of the antibodies for the epitope for which they were specific did not appear to be related to their effects on tau aggregation. These results confirm that antibody binding to tau's MBD repeat sequences may inhibit tau aggregation and indicate that such antibodies may also degrade preformed tau aggregates. In the presence of anti-tau antibodies, the resulting tau morphologies were antigen-dependent. The results also suggested the possibility of different pathways regulating antibody-mediated inhibition of tau aggregation and antibody-mediated degradation of preformed tau aggregates. PMID:25545358

  19. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

    PubMed Central

    Fuentealba, Rodrigo A.; Marasa, Jayne; Diamond, Marc I.; Piwnica-Worms, David; Weihl, Conrad C.

    2012-01-01

    Intracellular protein aggregation is a common pathologic feature in neurodegenerative diseases such as Huntington' disease, amyotrophic lateral sclerosis and Parkinson' disease. Although progress towards understanding protein aggregation in vitro has been made, little of this knowledge has translated to patient therapy. Moreover, mechanisms controlling aggregate formation and catabolism in cellulo remain poorly understood. One limitation is the lack of tools to quantitatively monitor protein aggregation and disaggregation. Here, we developed a protein-aggregation reporter that uses huntingtin exon 1 containing 72 glutamines fused to the N-terminal end of firefly luciferase (httQ72-Luc). httQ72-Luc fails to aggregate unless seeded by a non-luciferase-containing polyglutamine (polyQ) protein such as Q80-cfp. Upon co-aggregation, httQ72-luc becomes insoluble and loses its enzymatic activity. Using httQ72-Luc with Q80(CFP/YFP) as seeds, we screened the Johns Hopkins Clinical Compound Library and identified leflunomide, a dihydroorotate dehydrogenase inhibitor with immunosuppressive and anti-psoriatic activities, as a novel drug that prevents polyQ aggregation. Leflunomide and its active metabolite teriflunomide inhibited protein aggregation independently of their known role in pyrimidine biosynthesis, since neither uridine treatment nor other pyrimidine biosynthesis inhibitors affected polyQ aggregation. Inducible cell line and cycloheximide-chase experiments indicate that these drugs prevent incorporation of expanded polyQ into an aggregate. This study demonstrates the usefulness of luciferase-based protein aggregate reporters for high-throughput screening applications. As current trials are under-way for teriflunomide in the treatment of multiple sclerosis, we propose that this drug be considered a possible therapeutic agent for polyQ diseases. PMID:22052286

  20. Report of the Study Group on Yale College, 1972.

    ERIC Educational Resources Information Center

    Yale Univ., New Haven, CT.

    The Study Committee on Yale College was established to study all aspects of the college and to make recommendations for the next 20 years of operation. Recommendations include the areas of faculty role, student admissions, student role, the setting of undergraduate life, the appropriate range and limits of choice in learning, the process of…

  1. Community Based Organizations as Initiators of Partnerships with Community Colleges

    ERIC Educational Resources Information Center

    Turner, Sharon Yael

    2012-01-01

    This study focused on community based organizations leading community colleges in workforce development partnerships to train unemployed and underemployed adults. These collaborations operate where community based organizations deliver case management and job search skills, while community colleges offer specific training. In order to examine…

  2. The Changing Face of College Governance. LSDA Research Report.

    ERIC Educational Resources Information Center

    Davies, Peter

    The changing face of further education (FE) college governance in England and Wales was examined in a study that included the following activities: (1) a survey of 447 FE colleges across England and Wales (response rate, 55%) to identify the composition and operation of governing bodies, proposed changes, perceived developmental needs; and areas…

  3. IRS Releases Tax Questionnaire that Asks Colleges to Disclose More

    ERIC Educational Resources Information Center

    Kelderman, Eric

    2008-01-01

    Nearly 400 colleges across the United States are about to be asked to disclose intimate financial details of their operations to the Internal Revenue Service. This article reports on a highly detailed financial questionnaire designed by the IRS for the first phase of its Colleges and Universities Compliance Project, which is part of a continuing…

  4. An Evaluation of Milwaukee Area Technical College District. Report.

    ERIC Educational Resources Information Center

    Wade, Kate; Monroe, Kellie; Bajkiewicz, David; Coulthart, Tim; Osmanski, Thomas; Smyth, Conor; Sommerfeld, Robert

    The Legislative Audit Bureau of the State of Wisconsin analyzed financial issues concerning the Milwaukee Area Technical College (MATC). The MATC District is the largest district in Wisconsin's technical college system, with 12,504 FTE students enrolled and 1,944 staff in the 2001-02 academic year. Operating expenses for that year were $152.0…

  5. The College Program in the Georgia State Prison.

    ERIC Educational Resources Information Center

    George, Paul S.; And Others

    1980-01-01

    Describes the development and operation of the associate degree program conducted by South Georgia College at the Georgia State Prison, a large maximum security prison, and compares it with a similar program conducted by Tallahassee Community College at the Federal Correction Institution in Florida, a small minimum security prison. (JP)

  6. Utilizing Partnerships to Maximize Resources in College Counseling Services

    ERIC Educational Resources Information Center

    Stewart, Allison; Moffat, Meridith; Travers, Heather; Cummins, Douglas

    2015-01-01

    Research indicates an increasing number of college students are experiencing severe psychological problems that are impacting their academic performance. However, many colleges and universities operate with constrained budgets that limit their ability to provide adequate counseling services for their student population. Moreover, accessing…

  7. Colleges and Institutes: Advanced Skills for the Health Sector

    ERIC Educational Resources Information Center

    Association of Canadian Community Colleges, 2010

    2010-01-01

    This report provides the recommendations made by the Association of Canadian Community Colleges (ACCC) to the House of Commons Standing Committee on Health based from its examination on the health and human resources issues in Canada. Colleges are the advanced skills educators of choice. Aligned with the needs of employers, and operating on the…

  8. Building a Prosperous Economy. Washington's Community and Technical Colleges

    ERIC Educational Resources Information Center

    Washington State Board for Community and Technical Colleges, 2014

    2014-01-01

    Washington's community and technical colleges are a collective, powerful, unmatched resource for advancing prosperity through education. These 34 colleges not only connect with employers in the regions where they operate, but also with each other through common programs--like advanced manufacturing and allied health--that align with Washington's…

  9. Faculty Perceptions of Change Readiness in Liberal Arts Colleges

    ERIC Educational Resources Information Center

    Rupert, Lyle M.

    2015-01-01

    Due to the increasingly competitive environment in which liberal arts colleges operate and the constantly changing needs of students, colleges must continuously adapt and change in order to survive. Due to the high probability of failure when implementing change, it would serve an institution well to increase its readiness to change. This study…

  10. Financial Statement Audit Report of Tri-County Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Tri-County Community College financial statement audit for the fiscal year ending on June 30, 1998. Tri-County Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to…

  11. Financial Statement Audit Report of Halifax Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Halifax Community College financial statement audit for the fiscal year ending on June 30, 1998. Halifax Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to audit…

  12. Financial Statement Audit Report of Isothermal Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Isothermal Community College financial statement audit for the fiscal year ending on June 30, 1998. Isothermal Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to…

  13. Financial Statement Audit Report of Guilford Technical Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Guilford Technical Community College financial statement audit for the fiscal year ending on June 30, 1998. Guilford Technical Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were…

  14. Financial Statement Audit Report of Randolph Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Randolph Community College financial statement audit for the fiscal year ending on June 30, 1998. Randolph Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to audit…

  15. Financial Statement Audit Report of Pamlico Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Pamlico Community College financial statement audit for the fiscal year ending on June 30, 1998. Pamlico Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to audit…

  16. Financial Statement Audit Report of Rockingham Community College.

    ERIC Educational Resources Information Center

    Campbell, Ralph

    This report presents the results of the Rockingham Community College financial statement audit for the fiscal year ending on June 30, 1998. Rockingham Community College is a component of the State of North Carolina, thus the authority to audit is granted by Article 5A of G.S. 147. The accounts and operations of the institution were subject to…

  17. Community College Exemplary Instructional Programs, 1988-1989.

    ERIC Educational Resources Information Center

    Fideler, Elizabeth F., Ed.; Bazer, Gerald, Ed.

    Second in an annual series, this volume presents brief descriptions of a number of outstanding community college instructional programs identified by the National Council of Instructional Administrators (NCIA). Each description includes the address and telephone number of the college in which the program operates, and the names of the college…

  18. Illinois Community College Board Fiscal Year 2007 Spring Enrollment Report

    ERIC Educational Resources Information Center

    Illinois Community College Board, 2007

    2007-01-01

    Community colleges report opening Spring term enrollment figures to the Illinois Community College Board via a brief web based survey. These figures reflect only those students enrolled in credit courses that were operational on the census date (last day for course registration for regular classes). This report summarizes the survey results. This…

  19. Traditional Knowledge: An Implementation Workplan for Aurora College.

    ERIC Educational Resources Information Center

    Aurora Coll., Fort Smith (Northwest Territories).

    Prepared as part of an effort to make Aurora College, in the Northwest Territories, Canada, more responsive to the Native American communities that form its primary student base, this plan outline strategies for infusing traditional knowledge into the college's day-to-day operations. Following introductory sections describing traditional knowledge…

  20. Thermal Aggregation of Recombinant Protective Antigen: Aggregate Morphology and Growth Rate

    PubMed Central

    Belton, Daniel J.; Miller, Aline F.

    2013-01-01

    The thermal aggregation of the biopharmaceutical protein recombinant protective antigen (rPA) has been explored, and the associated kinetics and thermodynamic parameters have been extracted using optical and environmental scanning electron microscopies (ESEMs) and ultraviolet light scattering spectroscopy (UV-LSS). Visual observations and turbidity measurements provided an overall picture of the aggregation process, suggesting a two-step mechanism. Microscopy was used to examine the structure of aggregates, revealing an open morphology formed by the clustering of the microscopic aggregate particles. UV-LSS was used and developed to elucidate the growth rate of these particles, which formed in the first stage of the aggregation process. Their growth rate is observed to be high initially, before falling to converge on a final size that correlates with the ESEM data. The results suggest that the particle growth rate is limited by rPA monomer concentration, and by obtaining data over a range of incubation temperatures, an approach was developed to model the aggregation kinetics and extract the rate constants and the temperature dependence of aggregation. In doing so, we quantified the susceptibility of rPA aggregation under different temperature and environmental conditions and moreover demonstrated a novel use of UV spectrometry to monitor the particle aggregation quantitatively, in situ, in a nondestructive and time-resolved manner. PMID:23476645

  1. Space Costing: Who Should Pay for the Use of College Space? A Report.

    ERIC Educational Resources Information Center

    Zacher, Sy

    The costs of owning and operating physical facilities are consuming an increasing share of the budgets of colleges and universities. In the past, academic and operating units of colleges have viewed their space as a free commodity and often used it extravagantly. Space costing is a method of cost accounting the space and operating and maintenance…

  2. A Consortium Project to Improve Retention and the First Year of College: Results and Recommendations

    ERIC Educational Resources Information Center

    Cutright, Marc

    2006-01-01

    This article examines the operation and perceived effectiveness of a short-term, nine-community-college consortium, a consortium dedicated to the improvement of student retention and first-year education at each of the colleges in the consortium. The consortium was composed of Alabama community colleges, essentially during calendar year 2002. Its…

  3. Community/Junior College Alumni: Initiative, Influence, and Impact. A National Forum.

    ERIC Educational Resources Information Center

    McCracken, J. E.; And Others

    The development, operation, and benefits of community college alumni organizations are examined by four speakers. After J.E. McCracken's introduction to the topic, Thomas Ten Hoeve describes the alumni association at Butler County College and examines the role of the association in helping the college maintain updated files on former students and…

  4. Educating Students, Transforming Communities: Tribal Colleges Bridge Gap from Poverty to Prosperity

    ERIC Educational Resources Information Center

    Benton, Sherrole

    2012-01-01

    Tribal colleges are often performing little miracles in their communities. Most tribal colleges operate without benefit of local and state taxes. Yet, they bring in new money from other sources that stimulate the local economy. Students gain knowledge and skills that can transform their communities and local economies. Tribal colleges not only…

  5. Organizational Adaptation of Liberal Arts Colleges during the Great Recession of 2007

    ERIC Educational Resources Information Center

    Hilbun, Ashlie Junot; Mamiseishvili, Ketevan

    2016-01-01

    The study we report here explored how private liberal arts colleges adapted to the Great Recession of 2007. We examined institutional changes at three private liberal arts colleges and their effects on the institutions' operations. For this multiple-case study we analyzed data from three colleges in the southeastern region of the United States;…

  6. A Decision-Making Analysis of Fund Raising Options in a Public Community College.

    ERIC Educational Resources Information Center

    Chitwood, James P.

    Because financial stability of colleges and universities is threatened by level or decreased funding from all government sources, private resource development looms as a crucial element of community college operations in the next century. In order to determine the optimal private sources to target, Okaloosa-Walton Community College (OWCC), in…

  7. Radical Education in the Rural South: Commonwealth College, 1922-1940.

    ERIC Educational Resources Information Center

    Cobb, William H.

    Commonwealth College was the longest lived and most notorious of the resident labor colleges operating during the 1920s-30s. Founded in 1923 at NewLlano Cooperative Colony in Louisiana, the school was modeled on the self-maintenance characteristics of an abortive pre-war experiment in social education: Ruskin College. Disputes over priorities with…

  8. Structural determinants of Tau aggregation inhibitor potency.

    PubMed

    Schafer, Kelsey N; Cisek, Katryna; Huseby, Carol J; Chang, Edward; Kuret, Jeff

    2013-11-01

    Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we proposed ligand polarizability, a measure of electron delocalization, as a candidate descriptor of inhibitor potency. Here we tested this hypothesis by correlating the ground state polarizabilities of cyanine, phenothiazine, and arylmethine derivatives calculated using ab initio quantum methods with inhibitory potency values determined in the presence of octadecyl sulfate inducer under reducing conditions. A series of rhodanine analogs was analyzed as well using potency values disclosed in the literature. Results showed that polarizability and inhibitory potency directly correlated within all four series. To identify putative binding targets, representative members of the four chemotypes were added to aggregation reactions, where they were found to stabilize soluble, but SDS-resistant Tau species at the expense of filamentous aggregates. Using SDS resistance as a secondary assay, and a library of Tau deletion and missense mutants as targets, interaction with cyanine was localized to the microtubule binding repeat region. Moreover, the SDS-resistant phenotype was completely dependent on the presence of octadecyl sulfate inducer, but not intact PHF6/PH6* hexapeptide motifs, indicating that cyanine interacted with a species in the aggregation pathway prior to nucleus formation. Together the data suggest that flat, highly polarizable ligands inhibit Tau aggregation by interacting with folded species in the aggregation pathway and driving their assembly into soluble but highly stable Tau oligomers.

  9. Structural Determinants of Tau Aggregation Inhibitor Potency*

    PubMed Central

    Schafer, Kelsey N.; Cisek, Katryna; Huseby, Carol J.; Chang, Edward; Kuret, Jeff

    2013-01-01

    Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we proposed ligand polarizability, a measure of electron delocalization, as a candidate descriptor of inhibitor potency. Here we tested this hypothesis by correlating the ground state polarizabilities of cyanine, phenothiazine, and arylmethine derivatives calculated using ab initio quantum methods with inhibitory potency values determined in the presence of octadecyl sulfate inducer under reducing conditions. A series of rhodanine analogs was analyzed as well using potency values disclosed in the literature. Results showed that polarizability and inhibitory potency directly correlated within all four series. To identify putative binding targets, representative members of the four chemotypes were added to aggregation reactions, where they were found to stabilize soluble, but SDS-resistant Tau species at the expense of filamentous aggregates. Using SDS resistance as a secondary assay, and a library of Tau deletion and missense mutants as targets, interaction with cyanine was localized to the microtubule binding repeat region. Moreover, the SDS-resistant phenotype was completely dependent on the presence of octadecyl sulfate inducer, but not intact PHF6/PH6* hexapeptide motifs, indicating that cyanine interacted with a species in the aggregation pathway prior to nucleus formation. Together the data suggest that flat, highly polarizable ligands inhibit Tau aggregation by interacting with folded species in the aggregation pathway and driving their assembly into soluble but highly stable Tau oligomers. PMID:24072703

  10. Characterization of Ovine Dermal Papilla Cell Aggregation

    PubMed Central

    Sari, Agnes Rosarina Prita; Rufaut, Nicholas Wolfgang; Jones, Leslie Norman; Sinclair, Rodney Daniel

    2016-01-01

    Context: The dermal papilla (DP) is a condensation of mesenchymal cells at the proximal end of the hair follicle, which determines hair shaft size and regulates matrix cell proliferation and differentiation. DP cells have the ability to regenerate new hair follicles. These cells tend to aggregate both in vitro and in vivo. This tendency is associated with the ability of papilla cells to induce hair growth. However, human papilla cells lose their hair-inducing activity in later passage number. Ovine DP cells are different from human DP cells since they do not lose their aggregative behavior or hair-inducing activity in culture. Nonetheless, our understanding of ovine DP cells is still limited. Aim: The aim of this study was to observe the expression of established DP markers in ovine cells and their association with aggregation. Subjects and Methods: Ovine DP cells from three different sheep were compared. Histochemistry, immunoflourescence, and polymerase chain reaction experiments were done to analyze the DP markers. Results: We found that ovine DP aggregates expressed all the 16 markers evaluated, including alkaline phosphatase and versican. Expression of the versican V0 and V3 isoforms, neural cell adhesion molecule, and corin was increased significantly with aggregation, while hey-1 expression was significantly decreased. Conclusions: Overall, the stable expression of numerous markers suggests that aggregating ovine DP cells have a similar phenotype to papillae in vivo. The stability of their molecular phenotype is consistent with their robust aggregative behavior and retained follicle-inducing activity after prolonged culture. Their phenotypic stability in culture contrasts with DP cells from other species, and suggests that a better understanding of ovine DP cells might provide opportunities to improve the hair-inducing activity and therapeutic potential of human cells. PMID:27625564

  11. Characterization of Ovine Dermal Papilla Cell Aggregation

    PubMed Central

    Sari, Agnes Rosarina Prita; Rufaut, Nicholas Wolfgang; Jones, Leslie Norman; Sinclair, Rodney Daniel

    2016-01-01

    Context: The dermal papilla (DP) is a condensation of mesenchymal cells at the proximal end of the hair follicle, which determines hair shaft size and regulates matrix cell proliferation and differentiation. DP cells have the ability to regenerate new hair follicles. These cells tend to aggregate both in vitro and in vivo. This tendency is associated with the ability of papilla cells to induce hair growth. However, human papilla cells lose their hair-inducing activity in later passage number. Ovine DP cells are different from human DP cells since they do not lose their aggregative behavior or hair-inducing activity in culture. Nonetheless, our understanding of ovine DP cells is still limited. Aim: The aim of this study was to observe the expression of established DP markers in ovine cells and their association with aggregation. Subjects and Methods: Ovine DP cells from three different sheep were compared. Histochemistry, immunoflourescence, and polymerase chain reaction experiments were done to analyze the DP markers. Results: We found that ovine DP aggregates expressed all the 16 markers evaluated, including alkaline phosphatase and versican. Expression of the versican V0 and V3 isoforms, neural cell adhesion molecule, and corin was increased significantly with aggregation, while hey-1 expression was significantly decreased. Conclusions: Overall, the stable expression of numerous markers suggests that aggregating ovine DP cells have a similar phenotype to papillae in vivo. The stability of their molecular phenotype is consistent with their robust aggregative behavior and retained follicle-inducing activity after prolonged culture. Their phenotypic stability in culture contrasts with DP cells from other species, and suggests that a better understanding of ovine DP cells might provide opportunities to improve the hair-inducing activity and therapeutic potential of human cells.

  12. Lipid vesicle aggregation induced by cooling.

    PubMed

    Howard, Frank B; Levin, Ira W

    2010-01-01

    Lipid bilayer fusion is a complex process requiring several intermediate steps. Initially, the two bilayers are brought into close contact following removal of intervening water layers and overcoming electrostatic repulsions between opposing bilayer head groups. In this study we monitor by light scattering the reversible aggregation of phosphatidylcholine single shell vesicles during which adhesion occurs but stops prior to a fusion process. Light scattering measurements of dimyristoyl-sn-glycero-3-phosphocholine (DMPC), dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) in water show that lowering the temperature of about 0.14 micron single shell vesicles of DPPC (from 20 degrees C to 5 degrees C) and about 2 micron vesicles of DSPC (from 20 degrees C to 15 degrees C), but not of 1 micron vesicles of DMPC, results in extensive aggregation within 24 hours that is reversible by an increase in temperature. Aggregation of DSPC vesicles was confirmed by direct visual observation. Orientation of lipid head groups parallel to the plane of the bilayer and consequent reduction of the negative surface charge can account for the ability of DPPC and DSPC vesicles to aggregate. Retention of negatively charged phosphates on the surface and the burial of positively charged cholines within the bilayer offer an explanation for the failure of DMPC vesicles to aggregate. Lowering the temperature of 1,2-dipalmitoyl-sn-glycero-3-phosphoserine (DPPS) vesicles from 20 degrees C to 5 degrees C failed to increase aggregation within 24 hours at Mg(++)/DPPS ratios that begin to initiate aggregation and fusion.

  13. Remote sensing and airborne geophysics in the assessment of natural aggregate resources

    USGS Publications Warehouse

    Knepper, D.H.; Langer, W.H.; Miller, S.H.

    1994-01-01

    , and deposition of bedrock fragments. Consequently, most sand and gravel deposits are Tertiary or Quaternary in age and are most common in glaciated areas, alluvial basins, and along rivers and streams. The distribution of potential sources of natural aggregate in the United States is closely tied to physiography and the type of bedrock that occurs in an area. Using these criteria, the United States can be divided into 12 regions: western mountain ranges, alluvial basins, Columbia Plateau, Colorado Plateau and Wyoming basin, High Plains, nonglaciated central region, glaciated central region, Piedmont Blue Ridge region, glaciated northeastern and Superior uplands, Atlantic and Gulf coastal plain, Hawaiian Islands, and Alaska. Each region has similar types of natural aggregate sources within its boundary, although there may be wide variations in specific physical and chemical characteristics of the aggregates within a region. Conventional exploration for natural aggregate deposits has been largely a ground-based operation (field mapping, sampling, trenching and augering, resistivity), although aerial photos and topographic maps have been extensively used to target possible deposits for sampling and testing. Today, the exploration process also considers other factors such as the availability of the land, space and water supply for processing purposes, political and environmental factors, and distance from the market; exploration and planning cannot be separated. There are many physical properties and characteristics by which aggregate material is judged to be acceptable or unacceptable for specific applications; most of these properties and characteristics pertain only to individual aggregate particles and not to the bulk deposit. For example, properties of crushed stone aggregate particles such as thermal volume change, solubility, oxidation and hydration reactivity, and particle strength, among many others, are important consi

  14. What Good Is College? The Economics of College Attendance

    ERIC Educational Resources Information Center

    Covaleskie, John F.

    2014-01-01

    Until relatively recently, college was for only the few, and only loosely related to economic success. College graduates have always done economically better, on average, than those who did not graduate from college, but that was mostly because only the well-to-do could afford college. Few attended college in the hope of economic advancement in…

  15. What Are ACT's College Readiness Benchmarks? Issues in College Readiness

    ERIC Educational Resources Information Center

    ACT, Inc., 2010

    2010-01-01

    This article presents questions and answers about ACT's College Readiness Benchmarks. ACT's College Readiness Benchmarks are the minimum ACT test scores required for students to have a high probability of success in credit-bearing college courses--English Composition, social sciences courses, College Algebra, or Biology. Colleges can use the…

  16. Public versus Private Colleges: Political Participation of College Graduates

    ERIC Educational Resources Information Center

    Lott, Joe L., II.; Hernandez, Jose; King, Joe P.; Brown, Tiffany; Fajardo, Ismael

    2013-01-01

    Using data from the Baccalaureate and Beyond Longitudinal Study (B&B:93/03) of College Graduates, we use structural equation modeling to model the relationships between college major, values held in college, collegiate community service participation, and the post-college political participation of college graduates by public versus private…

  17. Aggregate vehicle travel forecasting model

    SciTech Connect

    Greene, D.L.; Chin, Shih-Miao; Gibson, R.

    1995-05-01

    This report describes a model for forecasting total US highway travel by all vehicle types, and its implementation in the form of a personal computer program. The model comprises a short-run, econometrically-based module for forecasting through the year 2000, as well as a structural, scenario-based longer term module for forecasting through 2030. The short-term module is driven primarily by economic variables. It includes a detailed vehicle stock model and permits the estimation of fuel use as well as vehicle travel. The longer-tenn module depends on demographic factors to a greater extent, but also on trends in key parameters such as vehicle load factors, and the dematerialization of GNP. Both passenger and freight vehicle movements are accounted for in both modules. The model has been implemented as a compiled program in the Fox-Pro database management system operating in the Windows environment.

  18. Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors

    PubMed Central

    Coan, Kristin E. D.

    2009-01-01

    Many false positives in early drug discovery owe to nonspecific inhibition by colloid-like aggregates of organic molecules. Despite their prevalence, little is known about aggregate concentration, structure, or dynamic equilibrium; the binding mechanism, stoichiometry with, and affinity for enzymes remain uncertain. To investigate the elementary question of concentration, we counted aggregate particles using flow cytometry. For seven aggregate-forming molecules, aggregates were not observed until the concentration of monomer crossed a threshold, indicating a “critical aggregation concentration” (CAC). Above the CAC, aggregate count increased linearly with added organic material, while the particles dispersed when diluted below the CAC. The concentration of monomeric organic molecule is constant above the CAC, as is the size of the aggregate particles. For two compounds that form large aggregates, nicardipine and miconazole, we measured particle numbers directly by flow cytometry, determining that the aggregate concentration just above the CAC ranged from 5 to 30 fM. By correlating inhibition of an enzyme with aggregate count for these two drugs, we determined that the stoichiometry of binding is about 10 000 enzyme molecules per aggregate particle. Using measured volumes for nicardipine and miconazole aggregate particles (2.1 × 1011 and 4.7 × 1010 Å3, respectively), computed monomer volumes, and the observation that past the CAC all additional monomer forms aggregate particles, we find that aggregates are densely packed particles. Finally, given their size and enzyme stoichiometry, all sequestered enzyme can be comfortably accommodated on the surface of the aggregate. PMID:18588298

  19. Structure and aggregation in model tetramethylurea solutions

    SciTech Connect

    Gupta, Rini; Patey, G. N.

    2014-08-14

    The structure of model aqueous tetramethylurea (TMU) solutions is investigated employing large-scale (32 000, 64 000 particles) molecular dynamics simulations. Results are reported for TMU mole fractions, X{sub t}, ranging from infinite dilution up to 0.07, and for two temperatures, 300 and 330 K. Two existing force fields for TMU-water solutions are considered. These are the GROMOS 53A6 united-atom TMU model combined with SPC/E water [TMU(GROMOS-UA)/W(SPC/E)], and the more frequently employed AMBER03 all-atom force field for TMU combined with the TIP3P water model [TMU(AMBER-AA)/W(TIP3P)]. It is shown that TMU has a tendency towards aggregation for both models considered, but the tendency is significantly stronger for the [TMU(AMBER-AA)/W(TIP3P)] force field. For this model signs of aggregation are detected at X{sub t} = 0.005, aggregation is a well established feature of the solution at X{sub t} = 0.02, and the aggregates increase further in size with increasing concentration. This is in agreement with at least some experimental studies, which report signals of aggregation in the low concentration regime. The TMU aggregates exhibit little structure and are simply loosely ordered, TMU-rich regions of solution. The [TMU(GROMOS-UA)/W(SPC/E)] model shows strong signs of aggregation only at higher concentrations (X{sub t} ≳ 0.04), and the aggregates appear more loosely ordered, and less well-defined than those occurring in the [TMU(AMBER-AA)/W(TIP3P)] system. For both models, TMU aggregation increases when the temperature is increased from 300 to 330 K, consistent with an underlying entropy driven, hydrophobic interaction mechanism. At X{sub t} = 0.07, the extra-molecular correlation length expected for microheterogeneous solutions has become comparable with the size of the simulation cell for both models considered, indicating that even the systems simulated here are sufficiently large only at low concentrations.

  20. Metaconcrete: Engineered aggregates for enhanced dynamic performance

    NASA Astrophysics Data System (ADS)

    Mitchell, Stephanie J.

    This work presents the development and investigation of a new type of concrete for the attenuation of waves induced by dynamic excitation. Recent progress in the field of metamaterials science has led to a range of novel composites which display unusual properties when interacting with electromagnetic, acoustic, and elastic waves. A new structural metamaterial with enhanced properties for dynamic loading applications is presented, which is named metaconcrete. In this new composite material the standard stone and gravel aggregates of regular concrete are replaced with spherical engineered inclusions. Each metaconcrete aggregate has a layered structure, consisting of a heavy core and a thin compliant outer coating. This structure allows for resonance at or near the eigenfrequencies of the inclusions, and the aggregates can be tuned so that resonant oscillations will be activated by particular frequencies of an applied dynamic loading. The activation of resonance within the aggregates causes the overall system to exhibit negative effective mass, which leads to attenuation of the applied wave motion. To investigate the behavior of metaconcrete slabs under a variety of different loading conditions a finite element slab model containing a periodic array of aggregates is utilized. The frequency dependent nature of metaconcrete is investigated by considering the transmission of wave energy through a slab, which indicates the presence of large attenuation bands near the resonant frequencies of the aggregates. Applying a blast wave loading to both an elastic slab and a slab model that incorporates the fracture characteristics of the mortar matrix reveals that a significant portion of the supplied energy can be absorbed by aggregates which are activated by the chosen blast wave profile. The transfer of energy from the mortar matrix to the metaconcrete aggregates leads to a significant reduction in the maximum longitudinal stress, greatly improving the ability of the material

  1. The Mechanisms of Aberrant Protein Aggregation

    NASA Astrophysics Data System (ADS)

    Cohen, Samuel; Vendruscolo, Michele; Dobson, Chris; Knowles, Tuomas

    2012-02-01

    We discuss the development of a kinetic theory for understanding the aberrant loss of solubility of proteins. The failure to maintain protein solubility results often in the assembly of organized linear structures, commonly known as amyloid fibrils, the formation of which is associated with over 50 clinical disorders including Alzheimer's and Parkinson's diseases. A true microscopic understanding of the mechanisms that drive these aggregation processes has proved difficult to achieve. To address this challenge, we apply the methodologies of chemical kinetics to the biomolecular self-assembly pathways related to protein aggregation. We discuss the relevant master equation and analytical approaches to studying it. In particular, we derive the underlying rate laws in closed-form using a self-consistent solution scheme; the solutions that we obtain reveal scaling behaviors that are very generally present in systems of growing linear aggregates, and, moreover, provide a general route through which to relate experimental measurements to mechanistic information. We conclude by outlining a study of the aggregation of the Alzheimer's amyloid-beta peptide. The study identifies the dominant microscopic mechanism of aggregation and reveals previously unidentified therapeutic strategies.

  2. Rotating bacteria aggregate into active crystals

    NASA Astrophysics Data System (ADS)

    Petroff, Alexander; Wu, Xiao-Lun; Libchaber, Albert

    2014-11-01

    The dynamics of many microbial ecosystems are determined not only by the response of individual bacteria to their chemical and physical environments but also the dynamics that emerge from interactions between cells. Here we investigate the collective dynamics displayed by communities of Thiovulum majus, one of the fastest known bacteria. We observe that when these bacteria swim close to a microscope cover slip, the cells spontaneously aggregate into a visually-striking two-dimensional hexagonal lattice of rotating cells. Each cell in an aggregate rotates its flagella, exerting a force that pushes the cell into the cover slip and a torque that causes the cell to rotate. As cells rotate against their neighbors, they exert forces and torques on the aggregate that cause the crystal to move and cells to hop to new positions in the lattice. We show how these dynamics arises from hydrodynamic and surface forces between cells. We derive the equations of motion for an aggregate, show that this model reproduces many aspects of the observed dynamics, and discuss the stability of these and similar active crystals. Finally, we discuss the ecological significance of this behavior to understand how the ability to aggregate into these communities may have evolved.

  3. Rotating Bacteria Aggregate into Active Crystals

    NASA Astrophysics Data System (ADS)

    Petroff, A. P.; Wu, X. L.; Libchaber, A.

    2014-12-01

    The dynamics of many microbial ecosystems are determined not only by the response of individual bacteria to their chemical and physical environments but also the dynamics that emerge from interactions between cells. Here we investigate collective dynamics displayed by communities of Thiovulum majus, one of the fastest known bacteria. We observe that when these bacteria swim close to a microscope cover slip, the cells spontaneously aggregate into a visually-striking, two-dimensional hexagonal lattice of rotating cells. Each cell in an aggregate rotates its flagella, exerting a force that pushes the cell into the cover slip and a torque that causes the cell to rotate. As cells rotate against their neighbors, they exert forces and torques on the aggregate that cause the crystal to move and cells to hop to new positions in the lattice. We show how these dynamics arise from hydrodynamic and surface forces between cells. We derive the equations of motion for an aggregate, show that this model reproduces many aspects of the observed dynamics, and discuss the stability of these and similar active crystals. Finally, we discuss the ecological significance of this behavior to understand how the ability to aggregate into these communities may have evolved.

  4. Particle aggregation with simultaneous surface growth

    SciTech Connect

    pablo.mitchell@cal.Berkeley.EDU

    2003-04-29

    Particle aggregation with simultaneous surface growth was modeled using a dynamic Monte Carlo method. The Monte Carlo algorithm begins in the particle inception zone and constructs aggregates via ensemble-averaged collisions between spheres and deposition of gaseous species on the sphere surfaces. Simulations were conducted using four scenarios. The first, referred to as scenario 0, is used as a benchmark and simulates aggregation in the absence of surface growth. Scenario 1 forces all balls to grow at a uniform rate while scenario 2 only permits them to grow once they have collided and stuck to each other. The last one is a test scenario constructed to confirm conclusions drawn from scenarios 0-2. The transition between the coalescent and the fully-developed fractal aggregation regimes is investigated using shape descriptors to quantify particle geometry. They are used to define the transition between the coalescent and fractal growth regimes. The simulations demonstrate that the morphology of aggregating particles is intimately related to both the surface deposition and particle nucleation rates.

  5. Static compression of porous dust aggregates

    NASA Astrophysics Data System (ADS)

    Kataoka, Akimasa; Tanaka, Hidekazu; Okuzumi, Satoshi; Wada, Koji

    2013-07-01

    To understand the structure evolution of dust aggregates is a key in the planetesimal formation. Dust grains become fluffy by coagulation in protoplanetary disks. However, once they become fluffy, they are not sufficiently compressed by collisional compression to form compact planetesimals (Okuzumi et al. 2012, ApJ, 752, 106). Thus, some other compression mechanisms are required to form planetesimals. We investigate the static compression of highly porous aggregates. First, we derive the compressive strength by numerical N-body simulations (Kataoka et al. 2013, A&A, 554, 4). Then, we apply the strength to protoplanetary disks, supposing that the highly porous aggregates can be quiasi-statically compressed by ram pressure of the disk gas and the self gravity. As a result, we find the pathway of the dust structure evolution from dust grains via fluffy aggregates to compact planetesimals. Moreover, we find that the fluffy aggregates overcome the barriers in planetesimal formation, which are radial drift, fragmentation, and bouncing barriers. (The paper is now available on arXiv: http://arxiv.org/abs/1307.7984 )

  6. Adsorption-induced reversible colloidal aggregation

    NASA Astrophysics Data System (ADS)

    Law, B. M.; Petit, J.-M.; Beysens, D.

    1998-05-01

    Reversible colloidal aggregation in binary liquid mixtures has been studied for a number of years. As the phase separation temperature of the liquid mixture is approached the thickness of an adsorption layer around the colloidal particles increases. Beysens et al. [Phys. Rev. Lett. 54, 2123 (1985); Ber. Bunsenges. Phys. Chem. 98, 382 (1994)] have demonstrated experimentally that this adsorption layer is intimately connected with the aggregation of the colloidal particles; however, no definitive theory has been available that can explain all of the experimental observations. In a recent work [J.-M. Petit, B. M. Law, and D. Beysens, J. Colloid Interface Sci. (to be published)] we have extended and improved the Derjaguin-Landau-Verwey-Overbeek theory of colloidal aggregation [E. J. W. Verwey and J. Th. G. Overbeek, Theory of the Stability of Lyophobic Colloids (Elsevier, New York, 1948)] by taking into account the presence of an adsorption layer and by more realistically modeling the attractive dispersion interactions using the Dzyaloshinskii-Lifshitz-Pitaevskii theory [Adv. Phys. 10, 165 (1961)]. In the present paper we apply this theory to a lutidine-water mixture containing a small volume fraction of silica colloidal particles. We demonstrate that the theory can quantitatively account for many of the experimentally observed features such as the characteristics of the aggregated state, the general shape of the aggregation line, and the temperature dependence of the second virial coefficient.

  7. Some Colleges Use Undercover Stings To Stop Drug Sales.

    ERIC Educational Resources Information Center

    Lively, Kit

    1998-01-01

    Increasingly, college and universities are allowing undercover police operations to halt drug trafficking involving students, hoping to break supply chains and convey the message that the institution takes drug policy seriously. Many students find the intrusion disturbing. (MSE)

  8. Mechanisms of carbon nanotube aggregation and the reversion of carbon nanotube aggregates in aqueous medium.

    PubMed

    Koh, Byumseok; Cheng, Wei

    2014-09-16

    Single-walled carbon nanotubes (SWCNTs) dispersed in aqueous medium have many potential applications in chemistry, biology, and medicine. Reversible aggregation of SWCNTs dispersed in water has been frequently reported, but the mechanisms behind are not well understood. Here we show that SWCNTs dispersed into aqueous medium assisted by various charged molecules can be reversibly aggregated by a variety of electrolytes with two distinct mechanisms. Direct binding of counterions to SWCNTs leads to aggregation when the surface charge is neutralized from 74 to 86%. This aggregation is driven by electrostatic instead of van der Waals interactions, thus showing similarity to that of DNA condensation induced by multivalent cations. Sequestration of counterions by chelating reagents leads to the redispersion of SWCNT aggregates. In contrast to various metal ions, polyelectrolytes have the unique ability to induce SWCNT aggregation by bridging between individual SWCNTs. Aggregation through the latter mechanism can be engineered to be reversible by exploiting various mechanisms of chain breaking, including reduction of disulfide bond in the polymer chain, and the cleavage action of proteolytic enzymes. These findings clarify the mechanisms of SWCNT aggregation, and have broad implications in various applications of SWCNTs in water. PMID:25144606

  9. Oil-Price Shocks: Beyond Standard Aggregate Demand/Aggregate Supply Analysis.

    ERIC Educational Resources Information Center

    Elwood, S. Kirk

    2001-01-01

    Explores the problems of portraying oil-price shocks using the aggregate demand/aggregate supply model. Presents a simple modification of the model that differentiates between production and absorption of goods, which enables it to better reflect the effects of oil-price shocks on open economies. (RLH)

  10. Protein aggregation and lyophilization: Protein structural descriptors as predictors of aggregation propensity

    PubMed Central

    Roughton, Brock C.; Iyer, Lavanya K.; Bertelsen, Esben; Topp, Elizabeth M.; Camarda, Kyle V.

    2014-01-01

    Lyophilization can induce aggregation in therapeutic proteins, but the relative importance of protein structure, formulation and processing conditions are poorly understood. To evaluate the contribution of protein structure to lyophilization-induced aggregation, fifteen proteins were co-lyophilized with each of five excipients. Extent of aggregation following lyophilization, measured using size-exclusion chromatography, was correlated with computational and biophysical protein structural descriptors via multiple linear regression. Descriptor selection was performed using exhaustive search and forward selection. The results demonstrate that, for a given excipient, extent of aggregation is highly correlated by eight to twelve structural descriptors. Leave-one-out cross validation showed that the correlations were able to successfully predict the aggregation for a protein “left out” of the data set. Selected descriptors varied with excipient, indicating both protein structure and excipient type contribute to lyophilization-induced aggregation. The results show some descriptors used to predict protein aggregation in solution are useful in predicting lyophilized protein aggregation. PMID:24516290

  11. Aggregation Pheromone System: A Real-parameter Optimization Algorithm using Aggregation Pheromones as the Base Metaphor

    NASA Astrophysics Data System (ADS)

    Tsutsui, Shigeyosi

    This paper proposes an aggregation pheromone system (APS) for solving real-parameter optimization problems using the collective behavior of individuals which communicate using aggregation pheromones. APS was tested on several test functions used in evolutionary computation. The results showed APS could solve real-parameter optimization problems fairly well. The sensitivity analysis of control parameters of APS is also studied.

  12. Caspase-Mediated Truncation of Tau Potentiates Aggregation

    PubMed Central

    Lee, Sangmook; Shea, Thomas B.

    2012-01-01

    Caspase-mediated truncation of tau is associated with aggregation. We examined the impact of manipulation of caspase activity on intracellular aggregation of a mutant form of tau (3PO) that forms spontaneous aggregates. Treatment with the caspase inhibitor Z-VAD-fmk reduced both N and C-terminal tau truncation but did not significantly reduce aggregation. Treatment with staurosporine, which activated caspases, increased C-terminal but not N-terminal truncation and enhanced aggregation. These findings suggest that caspase activation is one potential route, rather than an obligatory initiation step, in aggregation, and that N- and C-terminal truncation contribute differentially to aggregation. PMID:22988541

  13. Investigation on effects of aggregate structure in water and wastewater treatment.

    PubMed

    Chau, K W

    2004-01-01

    The fractal structure and particle size of flocs are generally recognized as the two most crucial physical properties having impact on the efficiency of operation of several unit processes in water and wastewater treatment. In this study, an experimental investigation is undertaken on the effect of aggregate structure in water and wastewater treatment in Hong Kong. The fractal dimension of the resulting aggregate is employed as a measure of the aggregate structure. Small angle light scattering technique is used here. Different amounts of polymers are mixed to bacterial suspensions and the resulting structures are examined. The addition of polymer may foster aggregate formation by neutralization of the bacterial surface charge and enhance inter-particle bridging. The aggregation behavior may affect the efficiency of certain water and wastewater treatment processes such as dewatering and coagulation. The impacts of aggregate structure on two representative processes, namely, ultra-filtration membrane fouling and pressure filter dewatering efficiency, are studied. It is found that the looser flocs yield a more porous cake and less tendency to foul whilst more porous filter cakes yield more ready biosolids dewatering.

  14. Synthetic lightweight aggregate from cool water slag: Bench-scale confirmation tests

    SciTech Connect

    Choudhry, V.; Hadley, S.R. )

    1990-05-01

    This report analyzes the potential for production of synthetic lightweight aggregate (SLA) from a Texaco coal gasification solid residue. The objective of the project was to develop a replacement for conventional lightweight aggregates typically derived from expanded clays and shales or natural lightweight aggregates. The sequence of tests performed to develop SLA from slag began with the crushing of samples of slag, followed by either extrusion or pelletization. The level of clay binder required for sufficient aggregate strength was evaluated. Using a tube furnace, expansion characteristics were studied as a function of temperature and residence time. Next, a large batch of SLA was produced in a muffle furnace and used to form concrete test cylinders. The unit weight of the resultant concrete was 105 lb/ft{sup 3}, with a compressive strength of 3100 psi, which meets the requirements specified in ASTM C 330 for lightweight aggregate of a comparable density. When the same sequence of tests was performed using a slag from which the bulk of the char had been removed, the concrete test cylinders showed an improved relationship between strength and density. Based on the results of bench-scale tests and the similarity to conventional LWA production, the conceptual design of an SLA processing plant was formulated. A comparative estimate of operating costs was prepared by analyzing data from plants using clays and shales to produce lightweight aggregates. 24 refs., 15 figs., 17 tabs.

  15. Suppression of protein aggregation by chaperone modification of high molecular weight complexes.

    PubMed

    Labbadia, John; Novoselov, Sergey S; Bett, John S; Weiss, Andreas; Paganetti, Paolo; Bates, Gillian P; Cheetham, Michael E

    2012-04-01

    Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington's disease. The cellular machinery for maintaining proteostasis includes molecular chaperones that facilitate protein folding and reduce proteotoxicity. Increasing the protein folding capacity of cells through manipulation of DNAJ chaperones has been shown to suppress aggregation and ameliorate polyglutamine toxicity in cells and flies. However, to date these promising findings have not been translated to mammalian models of disease. To address this issue, we developed transgenic mice that over-express the neuronal chaperone HSJ1a (DNAJB2a) and crossed them with the R6/2 mouse model of Huntington's disease. Over-expression of HSJ1a significantly reduced mutant huntingtin aggregation and enhanced solubility. Surprisingly, this was mediated through specific association with K63 ubiquitylated, detergent insoluble, higher order mutant huntingtin assemblies that decreased their ability to nucleate further aggregation. This was dependent on HSJ1a client binding ability, ubiquitin interaction and functional co-operation with HSP70. Importantly, these changes in mutant huntingtin solubility and aggregation led to improved neurological performance in R6/2 mice. These data reveal that prevention of further aggregation of detergent insoluble mutant huntingtin is an additional level of quality control for late stage chaperone-mediated neuroprotection. Furthermore, our findings represent an important proof of principle that DNAJ manipulation is a valid therapeutic approach for intervention in Huntington's disease.

  16. Center for Consumer Home Economics Education. Project Number 91-0095 and 91-0095, A-1 and A-2, January 31, 1992-June 30, 1993. A Report on Center Operation and Activities Conducted for California Community College Home Economics and Related Professionals.

    ERIC Educational Resources Information Center

    Mount San Antonio Coll., Walnut, CA.

    In an effort to improve community college home economics programs, the Chancellor's Office of the California Community Colleges established the Center for Consumer Home Economics Education (CCHEE) to provide support services for colleges receiving home economics MiniGrants, to establish linkages between colleges and the Chancellor's Office, and to…

  17. Cellular strategies for regulating functional and nonfunctional protein aggregation.

    PubMed

    Gsponer, Jörg; Babu, M Madan

    2012-11-29

    Growing evidence suggests that aggregation-prone proteins are both harmful and functional for a cell. How do cellular systems balance the detrimental and beneficial effect of protein aggregation? We reveal that aggregation-prone proteins are subject to differential transcriptional, translational, and degradation control compared to nonaggregation-prone proteins, which leads to their decreased synthesis, low abundance, and high turnover. Genetic modulators that enhance the aggregation phenotype are enriched in genes that influence expression homeostasis. Moreover, genes encoding aggregation-prone proteins are more likely to be harmful when overexpressed. The trends are evolutionarily conserved and suggest a strategy whereby cellular mechanisms specifically modulate the availability of aggregation-prone proteins to (1) keep concentrations below the critical ones required for aggregation and (2) shift the equilibrium between the monomeric and oligomeric/aggregate form, as explained by Le Chatelier's principle. This strategy may prevent formation of undesirable aggregates and keep functional assemblies/aggregates under control. PMID:23168257

  18. Student Guide for College Planning.

    ERIC Educational Resources Information Center

    Gibson, James; And Others

    This guide was prepared to inform students in Tacoma (Washington) public schools about the college admissions process. It notes that colleges have different selection criteria and discusses differences between community colleges and four-year colleges and between selection criteria in small, private colleges and large, public universities. A…

  19. Converting Work into College Credits

    ERIC Educational Resources Information Center

    Hoffman, Joseph A.

    1976-01-01

    The Cooperative Education Program conducted by the New Jersey Department of Labor and Industry and Thomas A. Edison College enables State labor department employees to work toward college degrees by attending free classes, taking college-level examinations for college credit, and converting work and life experiences into college credits.…

  20. [Aspects of the Junior College.

    ERIC Educational Resources Information Center

    Alt, Weston M.

    This series of eight briefs on the California junior college comprises (1) an argument in favor of the name "community" over "junior" college and remarks on a college campus vs. college district and on extended-district vs. single-campus functions, (2) what makes the junior college unique and the reasons for its increasing rate of growth, (3)…

  1. Organic carbon, water repellency and soil stability to slaking at aggregate and intra-aggregate scales

    NASA Astrophysics Data System (ADS)

    Jordán López, Antonio; García-Moreno, Jorge; Gordillo-Rivero, Ángel J.; Zavala, Lorena M.; Cerdà, Artemi; Alanís, Nancy; Jiménez-Compán, Elizabeth

    2015-04-01

    Water repellency (WR) is a property of some soils that inhibits or delays water infiltration between a few seconds and days or weeks. Inhibited or delayed infiltration contributes to ponding and increases runoff flow generation, often increasing soil erosion risk. In water-repellent soils, water infiltrates preferentially through cracks or macropores, causing irregular soil wetting patterns, the development of preferential flow paths and accelerated leaching of nutrients. Although low inputs of hydrophobic organic substances and high mineralization rates lead to low degrees of WR in cropped soils, it has been reported that conservative agricultural practices may induce soil WR. Although there are many studies at catchment, slope or plot scales very few studies have been carried out at particle or aggregate scale. Intra-aggregate heterogeneity of physical, biological and chemical properties conditions the transport of substances, microbial activity and biochemical processes, including changes in the amount, distribution and chemical properties of organic matter. Some authors have reported positive relationships between soil WR and aggregate stability, since it may delay the entry of water into aggregates, increase structural stability and contribute to reduce soil erosion risk. Organic C (OC) content, aggregate stability and WR are therefore strongly related parameters. In the case of agricultural soils, where both the type of management as crops can influence all these parameters, it is important to evaluate the interactions among them and their consequences. Studies focused on the intra-aggregate distribution of OC and WR are necessary to shed light on the soil processes at a detailed scale. It is extremely important to understand how the spatial distribution of OC in soil aggregates can protect against rapid water entry and help stabilize larger structural units or lead to preferential flow. The objectives of this research are to study [i] the OC content and the

  2. Enhanced Named Entity Extraction via Error-Driven Aggregation

    SciTech Connect

    Lemmond, T D; Perry, N C; Guensche, J W; Nitao, J J; Glaser, R E; Kidwell, P; Hanley, W G

    2010-02-22

    Despite recent advances in named entity extraction technologies, state-of-the-art extraction tools achieve insufficient accuracy rates for practical use in many operational settings. However, they are not generally prone to the same types of error, suggesting that substantial improvements may be achieved via appropriate combinations of existing tools, provided their behavior can be accurately characterized and quantified. In this paper, we present an inference methodology for the aggregation of named entity extraction technologies that is founded upon a black-box analysis of their respective error processes. This method has been shown to produce statistically significant improvements in extraction relative to standard performance metrics and to mitigate the weak performance of entity extractors operating under suboptimal conditions. Moreover, this approach provides a framework for quantifying uncertainty and has demonstrated the ability to reconstruct the truth when majority voting fails.

  3. Bed bug aggregation pheromone finally identified.

    PubMed

    Gries, Regine; Britton, Robert; Holmes, Michael; Zhai, Huimin; Draper, Jason; Gries, Gerhard

    2015-01-19

    Bed bugs have become a global epidemic and current detection tools are poorly suited for routine surveillance. Despite intense research on bed bug aggregation behavior and the aggregation pheromone, which could be used as a chemical lure, the complete composition of this pheromone has thus far proven elusive. Here, we report that the bed bug aggregation pheromone comprises five volatile components (dimethyl disulfide, dimethyl trisulfide, (E)-2-hexenal, (E)-2-octenal, 2-hexanone), which attract bed bugs to safe shelters, and one less-volatile component (histamine), which causes their arrestment upon contact. In infested premises, a blend of all six components is highly effective at luring bed bugs into traps. The trapping of juvenile and adult bed bugs, with or without recent blood meals, provides strong evidence that this unique pheromone bait could become an effective and inexpensive tool for bed bug detection and potentially their control. PMID:25529634

  4. Chemotaxis Control of Transient Cell Aggregation

    PubMed Central

    2015-01-01

    Chemotaxis affords motile cells the ability to rapidly respond to environmental challenges by navigating cells to niches favoring growth. Such a property results from the activities of dedicated signal transduction systems on the motility apparatus, such as flagella, type IV pili, and gliding machineries. Once cells have reached a niche with favorable conditions, they often stop moving and aggregate into complex communities termed biofilms. An intermediate and reversible stage that precedes commitment to permanent adhesion often includes transient cell-cell contacts between motile cells. Chemotaxis signaling has been implicated in modulating the transient aggregation of motile cells. Evidence further indicates that chemotaxis-dependent transient cell aggregation events are behavioral responses to changes in metabolic cues that temporarily prohibit permanent attachment by maintaining motility and chemotaxis. This minireview discusses a few examples illustrating the role of chemotaxis signaling in the initiation of cell-cell contacts in bacteria moving via flagella, pili, or gliding. PMID:26216846

  5. Chemotaxis Control of Transient Cell Aggregation.

    PubMed

    Alexandre, Gladys

    2015-10-01

    Chemotaxis affords motile cells the ability to rapidly respond to environmental challenges by navigating cells to niches favoring growth. Such a property results from the activities of dedicated signal transduction systems on the motility apparatus, such as flagella, type IV pili, and gliding machineries. Once cells have reached a niche with favorable conditions, they often stop moving and aggregate into complex communities termed biofilms. An intermediate and reversible stage that precedes commitment to permanent adhesion often includes transient cell-cell contacts between motile cells. Chemotaxis signaling has been implicated in modulating the transient aggregation of motile cells. Evidence further indicates that chemotaxis-dependent transient cell aggregation events are behavioral responses to changes in metabolic cues that temporarily prohibit permanent attachment by maintaining motility and chemotaxis. This minireview discusses a few examples illustrating the role of chemotaxis signaling in the initiation of cell-cell contacts in bacteria moving via flagella, pili, or gliding.

  6. Aggregation of organic matter by pelagic tunicates

    SciTech Connect

    Pomeroy, L.R.; Deibel, D.

    1980-07-01

    Three genera of pelagic tunicates were fed concentrates of natural seston and an axenic diatom culture. Fresh and up to 4-day-old feces resemble flocculent organic aggregates containing populations of microorganisms, as described from highly productive parts of the ocean, and older feces resemble the nearly sterile flocculent aggregates which are ubiquitous in surface waters. Fresh feces consist of partially digested phytoplankton and other inclusions in an amorphous gelatinous matrix. After 18 to 36 h, a population of large bacteria develops in the matrix and in some of the remains of phytoplankton contained in the feces. From 48 to 96 h, protozoan populations arise which consume the bacteria and sometimes the remains of the phytoplankton in the feces. Thereafter only a sparse population of microorganisms remains, and the particles begin to fragment. Water samples taken in or below dense populations of salps and doliolids contained greater numbers of flocculent aggregates than did samples from adjacent stations.

  7. Influence of polysaccharides on wine protein aggregation.

    PubMed

    Jaeckels, Nadine; Meier, Miriam; Dietrich, Helmut; Will, Frank; Decker, Heinz; Fronk, Petra

    2016-06-01

    Polysaccharides are the major high-molecular weight components of wines. In contrast, proteins occur only in small amounts in wine, but contribute to haze formation. The detailed mechanism of aggregation of these proteins, especially in combination with other wine components, remains unclear. This study demonstrates the different aggregation behavior between a buffer and a model wine system by dynamic light scattering. Arabinogalactan-protein, for example, shows an increased aggregation in the model wine system, while in the buffer system a reducing effect is observed. Thus, we could show the importance to examine the behavior of wine additives under conditions close to reality, instead of simpler buffer systems. Additional experiments on melting points of wine proteins reveal that only some isoforms of thaumatin-like proteins and chitinases are involved in haze formation. We can confirm interactions between polysaccharides and proteins, but none of these polysaccharides is able to prevent haze in wine.

  8. Extraction of TNT from aggregate soil fractions.

    PubMed

    Williford, C W; Mark Bricka, R

    1999-04-23

    Past explosives manufacture, disposal, and training activities have contaminated soil at many military facilities, posing health and environmental risks through contact, potential detonation, and leaching into ground water. While methods have been confirmed for extraction and measuring explosives concentration in soil, no work has addressed aggregate size material (the >2 mm gravel and cobbles) that often occurs with the smaller soil fractions. This paper describes methods and results for extraction and measurement of TNT (2,4,6-trinitrotoluene) in aggregate material from 1/2 to 2-1/1 from a WWII era ammunition plant. TNT was extracted into acetonitrile by both Soxhlet and ultrasonic extraction methods. High pressure liquid chromatography analyses of extracts showed expected variation among samples. Also effective extraction and determination of TNT concentration for each aggregate size fraction was achieved.

  9. The Nation's top 25 construction aggregates producers

    USGS Publications Warehouse

    Willett, Jason Christopher

    2013-01-01

    U.S. production of construction aggregates in 2011 was 2.17 billion short tons, valued at $17.2 billion, free on board (f.o.b.) at plant. Construction aggregates production decreased by 37 percent, and the associated value decreased by 25 percent, compared with the record highs reported in 2006. In 2011, construction aggregates production increased for the first time since 2006, owing to a very slight increase in the production of both construction sand and gravel and crushed stone. The average unit value, which is the f.o.b. at plant price of a ton of material, increased slightly, but is still less than the average unit value of two years prior.

  10. Refining aggregate exposure: example using parabens.

    PubMed

    Cowan-Ellsberry, Christina E; Robison, Steven H

    2009-12-01

    The need to understand and estimate quantitatively the aggregate exposure to ingredients used broadly in a variety of product types continues to grow. Currently aggregate exposure is most commonly estimated by using a very simplistic approach of adding or summing the exposures from all the individual product types in which the chemical is used. However, the more broadly the ingredient is used in related consumer products, the more likely this summation will result in an unrealistic estimate of exposure because individuals in the population vary in their patterns of product use including co-use and non-use. Furthermore the ingredient may not be used in all products of a given type. An approach is described for refining this aggregate exposure using data on (1) co-use and non-use patterns of product use, (2) extent of products in which the ingredient is used and (3) dermal penetration and metabolism. This approach and the relative refinement in the aggregate exposure from incorporating these data is illustrated using methyl, n-propyl, n-butyl and ethyl parabens, the most widely used preservative system in personal care and cosmetic products. When these refining factors were used, the aggregate exposure compared to the simple addition approach was reduced by 51%, 58%, 90% and 92% for methyl, n-propyl, n-butyl and ethyl parabens, respectively. Since biomonitoring integrates all sources and routes of exposure, the estimates using this approach were compared to available paraben biomonitoring data. Comparison to the 95th percentile of these data showed that these refined estimates were still conservative by factors of 2-92. All of our refined estimates of aggregate exposure are less than the ADI of 10mg/kg/day for parabens.

  11. The National Maritime College of Ireland

    ERIC Educational Resources Information Center

    Greville, Eamonn

    2005-01-01

    The new National Maritime College of Ireland is regarded as the country's most exciting and innovative development in maritime training and education and is the first tertiary institution to be built and operated under the government's Public Private Partnership (PPP) model of procurement. The project is the outcome of a partnership between Cork…

  12. Restaurant Training Recipe At Triton College

    ERIC Educational Resources Information Center

    Quagliano, Joseph

    1974-01-01

    The successful restaurant training program at Triton College (Illinois) involves a broadly based, two-year curriculum offering practical training in nearly all the areas associated with a comprehensive food operation--management, food preparation, menu planning, nutrition, personnel vending, dining room service, and cost control. (Author/EA)

  13. Assessing Financial Health in Community Colleges

    ERIC Educational Resources Information Center

    Bers, Trudy H.; Head, Ronald B.

    2014-01-01

    In this age of educational accountability, there is an increasing emphasis on assessment and institutional effectiveness, not only in the academic arena but also in other aspects of community college operation, such as fiscal health and stability, revenue generation, resource allocation, facilities, workforce development, and community enrichment…

  14. Maryland Community Colleges Instructional Program Manual.

    ERIC Educational Resources Information Center

    Maryland State Board for Community Colleges, Annapolis.

    Guidelines are presented for consideration in the development, review, submission, and approval of all new instructional programs in the Maryland Community Colleges (MCC). The first section of the manual explains: (1) operational definitions for transfer and occupational programs; (2) the five-year state plan listing; (3) letters of intent and…

  15. Public Relations for Community/Junior Colleges.

    ERIC Educational Resources Information Center

    Woodress, Fred A.

    This monograph is a practical manual on public relations (PR) for community and junior colleges, containing numerous suggestions and recommendations for establishing and operating an effective public relations effort while avoiding PR pitfalls. An overview of the history of public relations in academe, the rationale underlying today's PR programs…

  16. Glendale Community College Campus Profile '99.

    ERIC Educational Resources Information Center

    Spicer, Scot L.; Karpp, Edward R.; Amba, Conrad

    The Campus Profile is an annual publication designed to help faculty, staff, and students understand Glendale Community College's (California) diverse operations and make informed decisions. The publication is organized around the statewide accountability model. This year's Campus Profile includes more accountability performance measures than in…

  17. A demonstration of the virtual nursing college.

    PubMed

    Yensen, J A; Woolery, L K

    1995-01-01

    This demonstration will illustrate the operation of a virtual nursing college (VNC) through the Internet. The key concepts to be shown include: Distance and remote learning and teaching; Multi-site collaboration in teaching and clinical research using groupware; Multimedia courseware found in programmable virtual classrooms; Personal knowbots that manage information; Virtual clinics with virtual patients and simulated patients. PMID:8591569

  18. Critical Intellectual Inquiry at Catholic Colleges

    ERIC Educational Resources Information Center

    Olszewski, Bernard

    2006-01-01

    In this article, the author, a professor and an academic administrator at a Catholic college, discusses the topics of academic freedom and intellectual debate within the context of Catholic schools operating under guidelines of the Vatican document "Ex Corde Ecclesiae." Under these guidelines, there are fundamental moral questions that are not…

  19. Library Mechanization at Auburn Community College

    ERIC Educational Resources Information Center

    Hilbert, Eloise F.

    1970-01-01

    Use of an IBM 1401 computer and a single keypunch operation for changing a college book collection from Dewey decimal to Library of Congress classification; for acquisitions, accounting and circulation procedures; and for production of a list of periodical holdings. A mark-sense reproducer is used for the circulation system. (Editor)

  20. The Fundamentals of Community College Fund Raising.

    ERIC Educational Resources Information Center

    Brumbach, Mary A.; Bumphus, Walter G.

    1993-01-01

    Presents a guide for community college fund raising. Discusses organizational principles and structural models; operational concerns such as stewardship of funds, information dissemination, and donor research; and the importance of presidential support, institutional reputation and environment, and experienced grants managers. Includes practical…

  1. Library Automation in the Small College Environment.

    ERIC Educational Resources Information Center

    Worland, Peter B.; Nye, James H.

    The Folke Bernadotte Memorial Library contains 200,000 volumes and 900 serial subscriptions and operates with an annual budget as of 1974-75 of $235,000. It serves 2000 undergraduates in a 4 year liberal arts college. Library automation is used in the following areas: (1) bibliographic compilations; (2) cataloging of books, octavo choral…

  2. SURVEY REPORT--NAVAJO COMMUNITY COLLEGE.

    ERIC Educational Resources Information Center

    ASHE, ROBERT W.

    THIS PLAN FOR THE ESTABLISHMENT OF A NAVAJO JUNIOR COLLEGE GOES INTO ALL ASPECTS OF ITS ORGANIZATION. IT DESCRIBES THE PRESENT NAVAJO SCHOOL SYSTEM, WHICH IS A COMBINATION OF MISSION, PUBLIC, AND BUREAU OF INDIAN AFFAIRS OPERATIONS. FINANCIAL HELP TO STUDENTS WANTING MORE THAN A HIGH SCHOOL EDUCATION IS PRESENTLY INADEQUATE, THROUGH INCREASING. IF…

  3. Optical Properties and Aggregation of Graphene Nanoplatelets.

    PubMed

    Melezhyk, A V; Kotov, V A; Tkachev, A G

    2016-01-01

    In the present paper, the optical density of dispersions of randomly oriented multilayer graphene nanoplatelets (GNPs) was estimated. Calculated and experimental data were compared for aqueous GNP dispersions stabilized with various surfactants. It was shown that the sonication of an expanded graphite compound (EGC) in aqueous surfactant solutions leads to the transformation of EGC worm-like particles into weak GNP aggregates which are able to pass into solution upon dilution and agitation of the system. They may be filtered and washed out of surfactants. The concentrated GNP dispersions containing these weak aggregates can be used to synthesize different graphene-based nanostructures and obtain novel composite materials. PMID:27398570

  4. Average shape of transport-limited aggregates.

    PubMed

    Davidovitch, Benny; Choi, Jaehyuk; Bazant, Martin Z

    2005-08-12

    We study the relation between stochastic and continuous transport-limited growth models. We derive a nonlinear integro-differential equation for the average shape of stochastic aggregates, whose mean-field approximation is the corresponding continuous equation. Focusing on the advection-diffusion-limited aggregation (ADLA) model, we show that the average shape of the stochastic growth is similar, but not identical, to the corresponding continuous dynamics. Similar results should apply to DLA, thus explaining the known discrepancies between average DLA shapes and viscous fingers in a channel geometry. PMID:16196793

  5. Average Shape of Transport-Limited Aggregates

    NASA Astrophysics Data System (ADS)

    Davidovitch, Benny; Choi, Jaehyuk; Bazant, Martin Z.

    2005-08-01

    We study the relation between stochastic and continuous transport-limited growth models. We derive a nonlinear integro-differential equation for the average shape of stochastic aggregates, whose mean-field approximation is the corresponding continuous equation. Focusing on the advection-diffusion-limited aggregation (ADLA) model, we show that the average shape of the stochastic growth is similar, but not identical, to the corresponding continuous dynamics. Similar results should apply to DLA, thus explaining the known discrepancies between average DLA shapes and viscous fingers in a channel geometry.

  6. 200 North Aggregate Area source AAMS report

    SciTech Connect

    Not Available

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  7. Effect of urea on biomimetic aggregates.

    PubMed

    Florenzano, F H; Politi, M J

    1997-02-01

    The effect of urea on biomimetic aggregates (aqueous and reversed micelles, vesicles and monolayers) was investigated to obtain insights into the effect of the denaturant on structured macromolecules. Direct evidence obtained from light scattering (static and dynamic), monolayer maximum isothermal compression and ionic conductivity measurements, together with indirect evidence from fluorescence photodissociation, fluorescence suppression, and thermal reactions, strongly indicates the direct interaction mechanism of urea with the aggregates. Preferential solvation of the surfactant headgroups by urea results in an increase in the monomer dissociation degree (when applied), which leads to an increase in the area per headgroup and also in the loss of counterion affinities. PMID:9239302

  8. Practical Power System Aggregation Considering Dynamic Loads

    NASA Astrophysics Data System (ADS)

    Yamagishi, Yoshio; Komami, Shintaro

    This paper presents a practical method for creating power system equivalents that can be used in power system stability analysis. The proposed method uses three branches to connect the boundary bus, generator, and load. The method is suitable to consider reactance from the boundary bus to the load for power system stability studies using a dynamic load model. Furthermore, this paper presents a practical procedure to determine the parameters of the aggregated generator, including control devices such as excitation systems, PSS (power system stabilizer), and speed governors. The quality of the various aggregation models is verified using power system stability simulations.

  9. Production of prone-to-aggregate proteins.

    PubMed

    Lebendiker, Mario; Danieli, Tsafi

    2014-01-21

    Expression of recombinant proteins in Escherichia coli (E. coli) remains the most popular and cost-effective method for producing proteins in basic research and for pharmaceutical applications. Despite accumulating experience and methodologies developed over the years, production of recombinant proteins prone to aggregate in E. coli-based systems poses a major challenge in most research applications. The challenge of manufacturing these proteins for pharmaceutical applications is even greater. This review will discuss effective methods to reduce and even prevent the formation of aggregates in the course of recombinant protein production. We will focus on important steps along the production path, which include cloning, expression, purification, concentration, and storage. PMID:24211444

  10. Protein Aggregation Measurement through Electrical Impedance Spectroscopy

    NASA Astrophysics Data System (ADS)

    Affanni, A.; Corazza, A.; Esposito, G.; Fogolari, F.; Polano, M.

    2013-09-01

    The paper presents a novel methodology to measure the fibril formation in protein solutions. We designed a bench consisting of a sensor having interdigitated electrodes, a PDMS hermetic reservoir and an impedance meter automatically driven by calculator. The impedance data are interpolated with a lumped elements model and their change over time can provide information on the aggregation process. Encouraging results have been obtained by testing the methodology on K-casein, a protein of milk, with and without the addition of a drug inhibiting the aggregation. The amount of sample needed to perform this measurement is by far lower than the amount needed by fluorescence analysis.

  11. On the Optimization of a Probabilistic Data Aggregation Framework for Energy Efficiency in Wireless Sensor Networks.

    PubMed

    Kafetzoglou, Stella; Aristomenopoulos, Giorgos; Papavassiliou, Symeon

    2015-01-01

    Among the key aspects of the Internet of Things (IoT) is the integration of heterogeneous sensors in a distributed system that performs actions on the physical world based on environmental information gathered by sensors and application-related constraints and requirements. Numerous applications of Wireless Sensor Networks (WSNs) have appeared in various fields, from environmental monitoring, to tactical fields, and healthcare at home, promising to change our quality of life and facilitating the vision of sensor network enabled smart cities. Given the enormous requirements that emerge in such a setting-both in terms of data and energy-data aggregation appears as a key element in reducing the amount of traffic in wireless sensor networks and achieving energy conservation. Probabilistic frameworks have been introduced as operational efficient and performance effective solutions for data aggregation in distributed sensor networks. In this work, we introduce an overall optimization approach that improves and complements such frameworks towards identifying the optimal probability for a node to aggregate packets as well as the optimal aggregation period that a node should wait for performing aggregation, so as to minimize the overall energy consumption, while satisfying certain imposed delay constraints. Primal dual decomposition is employed to solve the corresponding optimization problem while simulation results demonstrate the operational efficiency of the proposed approach under different traffic and topology scenarios. PMID:26270664

  12. On the Optimization of a Probabilistic Data Aggregation Framework for Energy Efficiency in Wireless Sensor Networks

    PubMed Central

    Kafetzoglou, Stella; Aristomenopoulos, Giorgos; Papavassiliou, Symeon

    2015-01-01

    Among the key aspects of the Internet of Things (IoT) is the integration of heterogeneous sensors in a distributed system that performs actions on the physical world based on environmental information gathered by sensors and application-related constraints and requirements. Numerous applications of Wireless Sensor Networks (WSNs) have appeared in various fields, from environmental monitoring, to tactical fields, and healthcare at home, promising to change our quality of life and facilitating the vision of sensor network enabled smart cities. Given the enormous requirements that emerge in such a setting—both in terms of data and energy—data aggregation appears as a key element in reducing the amount of traffic in wireless sensor networks and achieving energy conservation. Probabilistic frameworks have been introduced as operational efficient and performance effective solutions for data aggregation in distributed sensor networks. In this work, we introduce an overall optimization approach that improves and complements such frameworks towards identifying the optimal probability for a node to aggregate packets as well as the optimal aggregation period that a node should wait for performing aggregation, so as to minimize the overall energy consumption, while satisfying certain imposed delay constraints. Primal dual decomposition is employed to solve the corresponding optimization problem while simulation results demonstrate the operational efficiency of the proposed approach under different traffic and topology scenarios. PMID:26270664

  13. On the Optimization of a Probabilistic Data Aggregation Framework for Energy Efficiency in Wireless Sensor Networks.

    PubMed

    Kafetzoglou, Stella; Aristomenopoulos, Giorgos; Papavassiliou, Symeon

    2015-08-11

    Among the key aspects of the Internet of Things (IoT) is the integration of heterogeneous sensors in a distributed system that performs actions on the physical world based on environmental information gathered by sensors and application-related constraints and requirements. Numerous applications of Wireless Sensor Networks (WSNs) have appeared in various fields, from environmental monitoring, to tactical fields, and healthcare at home, promising to change our quality of life and facilitating the vision of sensor network enabled smart cities. Given the enormous requirements that emerge in such a setting-both in terms of data and energy-data aggregation appears as a key element in reducing the amount of traffic in wireless sensor networks and achieving energy conservation. Probabilistic frameworks have been introduced as operational efficient and performance effective solutions for data aggregation in distributed sensor networks. In this work, we introduce an overall optimization approach that improves and complements such frameworks towards identifying the optimal probability for a node to aggregate packets as well as the optimal aggregation period that a node should wait for performing aggregation, so as to minimize the overall energy consumption, while satisfying certain imposed delay constraints. Primal dual decomposition is employed to solve the corresponding optimization problem while simulation results demonstrate the operational efficiency of the proposed approach under different traffic and topology scenarios.

  14. In-House vs. Franchise College Food Services and Bookstores.

    ERIC Educational Resources Information Center

    Stumph, W. J.

    In determining whether colleges or universities should operate their own food services or bookstores or lease them to contract operators, school business officers should consider a number of factors. These include whether sales volume is sufficiently large to cover direct operating costs and overhead; inventory investment; appearance, service, and…

  15. Co-Operative Education or Co-Operative Placement?

    ERIC Educational Resources Information Center

    Dickson, C. R.

    The Co-operative Education Department at Mohawk College is designed to extend the academic learning process into the workplace through on-the-job learning experiences which enhance the students' vocational maturation and personal development, and are integrated with the learning objectives of the program. The department offers paid, supervised…

  16. Institutional Characteristics and Student Retention in Public 4-Year Colleges and Universities

    ERIC Educational Resources Information Center

    Marsh, Gregory

    2014-01-01

    The purpose of this study was to determine the relative importance of specific student and institutional factors and characteristics on the retention of students at public, 4-year colleges and universities in the United States based on aggregate student cohort and institutional data. The overriding goal of this research was to identify any…

  17. College Applicants Who Took the COMPASS Test in 2006 (Part 1): Applicant Data

    ERIC Educational Resources Information Center

    Preuss, Michael

    2008-01-01

    The purpose of this ex post facto investigation was to determine the characteristics of and need for developmental education in the college applicant pool in 2006. Demographic data and COMPASS placement test results were gathered for the 1,079 applicants in 2006 who had complete records. These data were considered in the aggregate and in subsets…

  18. A Prediction Model for Community Colleges Using Graduation Rate as the Performance Indicator

    ERIC Educational Resources Information Center

    Moosai, Susan

    2010-01-01

    In this thesis a prediction model using graduation rate as the performance indicator is obtained for community colleges for three cohort years, 2003, 2004, and 2005 in the states of California, Florida, and Michigan. Multiple Regression analysis, using an aggregate of seven predictor variables, was employed in determining this prediction model.…

  19. From Aggregate Availability to Sustainability in California

    NASA Astrophysics Data System (ADS)

    Testa, S. M.; Parrish, J. G.

    2012-12-01

    California leads the nation in the production of sand and gravel, and ranks second behind Texas in the production of portland cement. Prior to 1960, the California Geological Survey (CGS, formerly the Division of Mines and Geology) and the State Mining and Geology Board (SMGB, formerly State Mining Board) placed an emphasis "in obtaining and providing information of benefit to the State's mineral industry". By the late 1960s, the Division initiated activities in the area of geologic hazards, and also expressed concern over the loss of aggregate resources via urbanization, which were among the state's most valuable mineral resource. Under the California Surface Mining and Reclamation Act of 1975 (SMARA), the State Geologist classifies mineral resources solely on geologic factors, and without regard to existing land use and land ownership. Following classification, the SMGB may consider "designating" such lands should the classified area contain mineral resources of regional or statewide economic significance and that may be needed to meet future demands. In 1979, the classification of aggregate resources in the three-county area of Los Angeles, Orange, and Ventura, was completed, with designation of such resources in Los Angeles County in 1981. Maps and descriptions of the designated mineral lands were placed in the California Public Resources Code and officially transmitted to those county and city governments having permitting authority over the use of those lands. In 1999, the SMGB in concert with CGS implemented the SMARA Regional Synthesis Map series, with the first (and last) of the series covering the Los Angeles Basin. This map was very useful for regional planners and the general citizenry since it provided a broader perspective not readily apparent in the smaller scale Production-Consumption (P-C) regional maps. CGS's statewide Aggregate Availability Map, commonly referred to as Map Sheet 52, was developed in 2002 and updated in 2006. The purpose of Map 52

  20. Aggregates for road building from Apulia region quarries

    NASA Astrophysics Data System (ADS)

    Simeone, Vincenzo; Doglioni, Angelo

    2013-04-01

    Apulia region is characterized by several quarries producing aggregates for road construction. A good knowledge of the technical behavior of aggregates is really important for the use. A laboratrory investigation has been developed in cooperation with Tecnoprove laboratory on 50 quarries from all over the Apulia region. Have been studied aggregates for road construction, avoiding weak rock quarry. The study has concerned unit weigth, compressive strength, wear and tear strength (Los Angeles test) and crushing strength. Tests have been made according to Italian rules for aggregates.Quarries from Foggia district were mainly located along the southern-western boundary of Gargano calcareous horst where back-reef limestone outcrop. Only two of the studied quarries were of alluvial deposits from the Appenine. The values of technical properties were quite interesting and also the variation coefficients have been really low witnessing that the material is quite homogeneous. Only a quarry, located really close to an important fault gave poor values. Quarries from Bari district dug limestone of the Mesozoic calcareous platform. The values of the compressive strength has been between 100 and 200 MPa, while the unit weight has beetween 26,5 and 25 kN/m3. Crushing coefficient values have been quite high. It due probably either to the corned shape of limestone aggregates or the fact that aggregates quarries are located where limestone are strongly tectonized. Quarries from Brindisi and Taranto districts even are oper in Mesozoic calcareous platform unit gave the worst values of compressive strength and other technical properties. The compressive strength was normally lower than 100 MPa. The Also crushing test and the Los Angeles test has given values quite poor. Compressive strength values of limestone are strongly variable, with an high coefficient of variation (more than 30%).Probably it is due to the fact that all the studied quarries are located along the boundary of the

  1. Alpha--College for Exploring

    ERIC Educational Resources Information Center

    Leppert, William; Koenig, Joan

    1976-01-01

    Describes Alpha, the experimental college of individualized instruction at the College of DuPage (Illinois). At this college, students design their own curricula and work in an open classroom situation, and teachers start with students instead of subjects. (DC)

  2. College Drinking - Changing the Culture

    MedlinePlus

    ... about college alcohol policies College Drinking - Changing the Culture This is your one-stop resource for comprehensive ... More about special features College Drinking - Changing the Culture This is your one-stop resource for comprehensive ...

  3. College Health for Young Women

    MedlinePlus

    ... important for me to know about before I go to college? Filling out your college enrollment health ... this information with other important papers when you go to college. Your immunizations must be up-to- ...

  4. Health Care for College Students

    MedlinePlus

    ... t exercise or play through pain. Mononucleosis ("Mono") College students often worry about a disease called " mono "—also ... Additional Information: Meningococcal Disease: Information for Teens and College Students Healthy Tips for College Freshman Encouraging Teens to ...

  5. Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway.

    PubMed

    Thapa, Arjun; Jett, Stephen D; Chi, Eva Y

    2016-01-20

    The abnormal misfolding and aggregation of amyloid-β (Aβ) peptides into β-sheet enriched insoluble deposits initiates a cascade of events leading to pathological processes and culminating in cognitive decline in Alzheimer's disease (AD). In particular, soluble oligomeric/prefibrillar Aβ have been shown to be potent neurotoxins. The naturally occurring polyphenol curcumin has been shown to exert a neuroprotective effect against age-related neurodegenerative diseases such as AD. However, its protective mechanism remains unclear. In this study, we investigated the effects of curcumin on the aggregation of Aβ40 as well as Aβ40 aggregate induced neurotoxicity. Our results show that the curcumin does not inhibit Aβ fibril formation, but rather enriches the population of "off-pathway" soluble oligomers and prefibrillar aggregates that were nontoxic. Curcumin also exerted a nonspecific neuroprotective effect, reducing toxicities induced by a range of Aβ conformers, including monomeric, oligomeric, prefibrillar, and fibrillar Aβ. The neuroprotective effect is possibly membrane-mediated, as curcumin reduced the extent of cell membrane permeabilization induced by Aβ aggregates. Taken together, our study shows that curcumin exerts its neuroprotective effect against Aβ induced toxicity through at least two concerted pathways, modifying the Aβ aggregation pathway toward the formation of nontoxic aggregates and ameliorating Aβ-induced toxicity possibly through a nonspecific pathway.

  6. Mobile marine operations structure

    SciTech Connect

    Bhalaik, A.; Braddick, P.W.; Brittin, D.S.; Johnson, G.L.

    1988-02-16

    The process of fabricating a marine operations structure having a central core and first and second ice walls circumferentially positioned about the central core for fracturing ice features, with the second ice wall above and contiguous with the first ice wall, wherein the first and second ice walls are constructed according to the process is described comprising the steps of: providing a sloping support base system comprising radial bulkheads and circumferentially-positioned web frame series integrally connecting ice wall plating to the bulkheads and web frames series; integrally affixing an exposed cross grid system of interlocking and reinforcing members to the exterior surfaces of the ice wall plating to form first and second ice wall preforms with the members projecting outward from the plating; installing a slip-form adjacent to the ice wall preforms and exteriorly of the plating; pouring cement/aggregate slurry onto the ice wall preforms between the plating and the slip-form to cover the cross grid of interlocking and reinforcing members; moving the slip-form upwards as the void spaces between the slip-form and the ice wall plating are filled with cement/aggregate slurry; and permitting the cement/aggregate slurry to harden to form an orthotropic composite steel/concrete ice wall with an exposed concrete surface.

  7. Zinc significantly changes the aggregation pathway and the conformation of aggregates of human prion protein.

    PubMed

    Pan, Kai; Yi, Chuan-Wei; Chen, Jie; Liang, Yi

    2015-08-01

    Prion diseases are caused by the conformational change of cellular prion protein PrP(C) into pathological prion protein PrP(Sc). Here we study the effect of zinc on the aggregation and conformational change of human prion protein (PrP). As revealed by thioflavin T binding assays, Sarkosyl-soluble SDS-PAGE, and transmission electron microscopy, aggregation of wild-type PrP in the absence of Zn(2+) undergoes four steps: amorphous aggregates, profibrils, mature fibrils, and fragmented fibrils. When the molar ratio of Zn(2+) to PrP was 9:1, however, aggregation of wild-type PrP undergoes another pathway in which wild-type PrP forms oligomers quickly and then forms short-rod aggregates. Unlike wild-type PrP, the octarepeats deletion mutant PrPΔocta forms typical mature fibrils either with or without zinc. As evidenced by isothermal titration calorimetry, Fourier transform infrared spectroscopy, and proteinase K digestion assays, Zn(2+) strongly binds to wild-type PrP monomers with the first binding constant exceeding 10(7)M(-1) under denaturing conditions, and changes the conformation of wild-type PrP aggregates remarkably, but weakly binds to PrPΔocta with binding affinity around 10(4)M(-1) and has no obvious effects on the conformation of PrPΔocta aggregates. Our data demonstrate that zinc significantly changes the aggregation pathway and the conformation of wild-type PrP aggregates mainly via interaction with its octarepeat region. Our findings could explain how zinc modifies pathological PrP conformation associated with prion diseases.

  8. Single particle detection and characterization of synuclein co-aggregation

    SciTech Connect

    Giese, Armin . E-mail: Armin.Giese@med.uni-muenchen.de; Bader, Benedikt; Bieschke, Jan; Schaffar, Gregor; Odoy, Sabine; Kahle, Philipp J.; Haass, Christian; Kretzschmar, Hans

    2005-08-12

    Protein aggregation is the key event in a number of human diseases such as Alzheimer's and Parkinson's disease. We present a general method to quantify and characterize protein aggregates by dual-colour scanning for intensely fluorescent targets (SIFT). In addition to high sensitivity, this approach offers a unique opportunity to study co-aggregation processes. As the ratio of two fluorescently labelled components can be analysed for each aggregate separately in a homogeneous assay, the molecular composition of aggregates can be studied even in samples containing a mixture of different types of aggregates. Using this method, we could show that wild-type {alpha}-synuclein forms co-aggregates with a mutant variant found in familial Parkinson's disease. Moreover, we found a striking increase in aggregate formation at non-equimolar mixing ratios, which may have important therapeutic implications, as lowering the relative amount of aberrant protein may cause an increase of protein aggregation leading to adverse effects.

  9. EFFECT OF AGGREGATION ON VIBRIO CHOLERAE INACTIVATION

    EPA Science Inventory

    Extensive research has shown that microorganisms exhibit increased resistance due to clumping, aggregation, particle association, or modification of antecedent growth conditions. During the course of investigating a major water-borne Vibrio cholerae outbreak in Peru, U.S. EPA inv...

  10. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... same floodplain, and are currently under review by the Department (or by a grant recipient subject to 24 CFR part 58), individual or aggregated approvals may be issued. A single compliance review and... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24...

  11. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... same floodplain, and are currently under review by the Department (or by a grant recipient subject to 24 CFR part 58), individual or aggregated approvals may be issued. A single compliance review and... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24...

  12. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... same floodplain, and are currently under review by the Department (or by a grant recipient subject to 24 CFR part 58), individual or aggregated approvals may be issued. A single compliance review and... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24...

  13. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., require compliance with subpart C of this part, affect the same floodplain or wetland, and are currently under review by HUD (or by a responsible entity authorized by 24 CFR part 58), individual or aggregated... FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS Procedures for Making Determinations on...

  14. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... same floodplain, and are currently under review by the Department (or by a grant recipient subject to 24 CFR part 58), individual or aggregated approvals may be issued. A single compliance review and... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24...

  15. Regulation and aggregation of intrinsically disordered peptides.

    PubMed

    Levine, Zachary A; Larini, Luca; LaPointe, Nichole E; Feinstein, Stuart C; Shea, Joan-Emma

    2015-03-01

    Intrinsically disordered proteins (IDPs) are a unique class of proteins that have no stable native structure, a feature that allows them to adopt a wide variety of extended and compact conformations that facilitate a large number of vital physiological functions. One of the most well-known IDPs is the microtubule-associated tau protein, which regulates microtubule growth in the nervous system. However, dysfunctions in tau can lead to tau oligomerization, fibril formation, and neurodegenerative disease, including Alzheimer's disease. Using a combination of simulations and experiments, we explore the role of osmolytes in regulating the conformation and aggregation propensities of the R2/wt peptide, a fragment of tau containing the aggregating paired helical filament (PHF6*). We show that the osmolytes urea and trimethylamine N-oxide (TMAO) shift the population of IDP monomer structures, but that no new conformational ensembles emerge. Although urea halts aggregation, TMAO promotes the formation of compact oligomers (including helical oligomers) through a newly proposed mechanism of redistribution of water around the perimeter of the peptide. We put forth a "superposition of ensembles" hypothesis to rationalize the mechanism by which IDP structure and aggregation is regulated in the cell.

  16. Platelet aggregating material from equine arterial tissue

    SciTech Connect

    Schneider, M.D.

    1983-02-22

    Novel hemostatic agent comprises equine arterial fibrillar collagen in a carrier. The agent is useful for the aggregation of platelets for clinical diagnostic tests and for the clotting of blood, such as for controlling bleeding in warm blooded species. The fibrillar collagen is obtained by extracting homogenized equine arterial tissue with aqueous solutions followed by extensive dialysis. No Drawings

  17. Utilitarian Aggregation of Beliefs and Tastes.

    ERIC Educational Resources Information Center

    Gilboa, Itzhak; Samet, Dov; Schmeidler, David

    2004-01-01

    Harsanyi's utilitarianism is extended here to Savage's framework. We formulate a Pareto condition that implies that both society's utility function and its probability measure are linear combinations of those of the individuals. An indiscriminate Pareto condition has been shown to contradict linear aggregation of beliefs and tastes. We argue that…

  18. 28 CFR 2.5 - Sentence aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Sentence aggregation. 2.5 Section 2.5 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS... by the Commission pursuant to these rules, and the prisoner has a single parole eligibility date...

  19. 28 CFR 2.5 - Sentence aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Sentence aggregation. 2.5 Section 2.5 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS... by the Commission pursuant to these rules, and the prisoner has a single parole eligibility date...

  20. 28 CFR 2.5 - Sentence aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Sentence aggregation. 2.5 Section 2.5 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS... by the Commission pursuant to these rules, and the prisoner has a single parole eligibility date...

  1. 28 CFR 2.5 - Sentence aggregation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Sentence aggregation. 2.5 Section 2.5 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS... by the Commission pursuant to these rules, and the prisoner has a single parole eligibility date...

  2. 78 FR 68945 - Aggregation of Positions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ..., 76 FR 71626 (Nov. 18, 2011). In an Order dated September 28, 2012, the District Court for the... Futures and Swaps, 77 FR 31767 (May 30, 2012). First, the Commission proposed to amend regulation 151.7(i... (``1979 Aggregation Policy''), 44 FR 33839, 33843 (June 13, 1979). Note, however, that consistent with...

  3. Metaconcrete: designed aggregates to enhance dynamic performance

    NASA Astrophysics Data System (ADS)

    Mitchell, Stephanie J.; Pandolfi, Anna; Ortiz, Michael

    2014-04-01

    We propose a new type of concrete for the attenuation of elastic waves induced by dynamic excitation. In this metamaterial, which we call metaconcrete, the stone, sand, and gravel aggregates of standard concrete are replaced with spherical inclusions consisting of a heavy metal core coated with a soft outer layer. These engineered aggregates can be tuned so that particular frequencies of a propagating blast wave will activate resonant oscillations of the heavy mass within the inclusions. The resonant behavior causes the system to exhibit negative effective mass, and this interaction between the wave motion and the resonant aggregates results in the attenuation of the applied dynamic loading. We introduce the concept of negative mass by deriving the effective momentum mass for the system and we define the geometrical and material parameters for the design of resonant aggregates. We develop finite element models for the analysis of metaconcrete behavior, defining a section of slab containing a periodic arrangement of inclusions. By computing the energy histories for the system when subject to a blast load, we show that there is a transfer of energy between the inclusions and the surrounding mortar. The inclusions are able to absorb a significant portion of the applied energy, resulting in a reduction in the amount of stress carried by the mortar phase and greatly improving the ability of the material to resist damage under explosive dynamic loading.

  4. 42 CFR 425.702 - Aggregate reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... following information, deidentified in accordance with 45 CFR 164.514(b): (1) Aggregated metrics on the assigned beneficiary population. (2) Utilization and expenditure data at the start of the agreement period... beginning of each performance year, CMS, upon the ACO's request for the data for purposes of...

  5. Colloidal aggregation and dynamics in anisotropic fluids

    PubMed Central

    Mondiot, Frédéric; Botet, Robert; Snabre, Patrick; Mondain-Monval, Olivier; Loudet, Jean-Christophe

    2014-01-01

    We present experiments and numerical simulations to investigate the collective behavior of submicrometer-sized particles immersed in a nematic micellar solution. We use latex spheres with diameters ranging from 190 to 780 nm and study their aggregation properties due to the interplay of the various colloidal forces at work in the system. We found that the morphology of aggregates strongly depends on the particle size, with evidence for two distinct regimes: the biggest inclusions clump together within minutes into either compact clusters or V-like structures that are completely consistent with attractive elastic interactions. On the contrary, the smallest particles form chains elongated along the nematic axis, within comparable timescales. In this regime, Monte Carlo simulations, based on a modified diffusion-limited cluster aggregation model, strongly suggest that the anisotropic rotational Brownian motion of the clusters combined with short-range depletion interactions dominate the system coarsening; elastic interactions no longer prevail. The simulations reproduce the sharp transition between the two regimes on increasing the particle size. We provide reasonable estimates to interpret our data and propose a likely scenario for colloidal aggregation. These results emphasize the growing importance of the diffusion of species at suboptical-wavelength scales and raise a number of fundamental issues. PMID:24715727

  6. 32 CFR 701.46 - Aggregating requests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC FOIA Fees § 701.46 Aggregating requests. Except for...

  7. 32 CFR 701.46 - Aggregating requests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC FOIA Fees § 701.46 Aggregating requests. Except for...

  8. 32 CFR 701.46 - Aggregating requests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC FOIA Fees § 701.46 Aggregating requests. Except for...

  9. Aggregate Unemployment Decreases Individual Returns to Education

    ERIC Educational Resources Information Center

    Ammermueller, Andreas; Kuckulenz, Anja; Zwick, Thomas

    2009-01-01

    Aggregate unemployment may affect individual returns to education through qualification-specific responses in participation and wage bargaining. This paper shows that an increase in regional unemployment by 1% decreases returns to education by 0.005 percentage points. This implies that higher skilled employees are better sheltered from labour…

  10. Platelet aggregating material from equine arterial tissue

    DOEpatents

    Schneider, Morris D.

    1983-02-22

    Novel hemostatic agent comprises equine arterial fibrillar collagen in a carrier. The agent is useful for the aggregation of platelets for clinical diagnostic tests and for the clotting of blood, such as for controlling bleeding in warm blooded species. The fibrillar collagen is obtained by extracting homogenized equine arterial tissue with aqueous solutions followed by extensive dialysis.

  11. 31 CFR 1020.313 - Aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Aggregation. 1020.313 Section 1020.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULE FOR BANKS Reports Required To Be Made By Banks §...

  12. 31 CFR 1010.313 - Aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS Reports Required To Be Made § 1010.313 Aggregation. (a) Multiple branches. A financial institution includes all of its domestic branch offices,...

  13. 31 CFR 1010.313 - Aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS Reports Required To Be Made § 1010.313 Aggregation. (a) Multiple branches. A financial institution includes all of its domestic branch offices,...

  14. 31 CFR 1010.313 - Aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS Reports Required To Be Made § 1010.313 Aggregation. (a) Multiple branches. A financial institution includes all of its domestic branch offices,...

  15. 31 CFR 1010.313 - Aggregation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS Reports Required To Be Made § 1010.313 Aggregation. (a) Multiple branches. A financial institution includes all of its domestic branch offices,...

  16. 31 CFR 1020.313 - Aggregation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Aggregation. 1020.313 Section 1020.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULE FOR BANKS Reports Required To Be Made By Banks §...

  17. 31 CFR 1020.313 - Aggregation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Aggregation. 1020.313 Section 1020.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULE FOR BANKS Reports Required To Be Made By Banks §...

  18. 31 CFR 1020.313 - Aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Aggregation. 1020.313 Section 1020.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULE FOR BANKS Reports Required To Be Made By Banks §...

  19. Aggregation of MBP in chronic demyelination

    PubMed Central

    Frid, Kati; Einstein, Ofira; Friedman-Levi, Yael; Binyamin, Orli; Ben-Hur, Tamir; Gabizon, Ruth

    2015-01-01

    Objectives Misfolding of key disease proteins to an insoluble state is associated with most neurodegenerative conditions, such as prion, Parkinson, and Alzheimer’s diseases. In this work, and by studying animal models of multiple sclerosis, we asked whether this is also the case for myelin basic protein (MBP) in the late and neurodegenerative phases of demyelinating diseases. Methods To this effect, we tested whether MBP, an essential myelin component, present prion-like properties in animal models of MS, as is the case for Cuprizone-induced chronic demyelination or chronic phases of Experimental Autoimmune Encephalomyelitis (EAE). Results We show here that while total levels of MBP were not reduced following extensive demyelination, part of these molecules accumulated thereafter as aggregates inside oligodendrocytes or around neuronal cells. In chronic EAE, MBP precipitated concomitantly with Tau, a marker of diverse neurodegenerative conditions, including MS. Most important, analysis of fractions from Triton X-100 floatation gradients suggest that the lipid composition of brain membranes in chronic EAE differs significantly from that of naïve mice, an effect which may relate to oxidative insults and subsequently prevent the appropriate insertion and compaction of new MBP in the myelin sheath, thereby causing its misfolding and aggregation. Interpretation Prion-like aggregation of MBP following chronic demyelination may result from an aberrant lipid composition accompanying this pathological status. Such aggregation of MBP may contribute to neuronal damage that occurs in the progressive phase of MS. PMID:26273684

  20. 42 CFR 425.702 - Aggregate reports.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... following information, deidentified in accordance with 45 CFR 164.514(b): (1) Aggregated metrics on the assigned beneficiary population. (2) Utilization and expenditure data at the start of the agreement period... beginning of each performance year, CMS, upon the ACO's request for the data for purposes of...