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Sample records for aggregate generational current

  1. DNA Generated Electric Current Biosensor.

    PubMed

    Hu, Lanshuang; Hu, Shengqiang; Guo, Linyan; Shen, Congcong; Yang, Minghui; Rasooly, Avraham

    2017-02-21

    In addition to its primary function as a genetic material, deoxyribonucleic acid (DNA) is also a potential biologic energy source for molecular electronics. For the first time, we demonstrate that DNA can generate a redox electric current. As an example of this new functionality, DNA generated redox current was used for electrochemical detection of human epidermal growth factor receptor 2 (HER2), a clinically important breast cancer biomarker. To induce redox current, the phosphate of the single stranded DNA aptamer backbone was reacted with molybdate to form redox molybdophosphate precipitate and generate an electrochemical current of ∼16.8 μA/μM cm(2). This detection of HER2 was performed using a sandwich detection assay. A HER2 specific peptide was immobilized onto a gold electrode surface for capturing HER2 in buffer and serum. The HER2 specific aptamer was used as both ligand to bind the captured HER2 and to generate a redox current signal. When tested for HER2 detection, the electrochemical current generated by the aptasensor was proportional to HER2 concentration in the range of 0.01 to 5 ng/mL, with a current generated in the range of ∼6.37 to 31.8 μA/cm(2) in both buffer and serum. This detection level is within the clinically relevant range of HER2 concentrations. This method of electrochemical signal amplification greatly simplifies the signal transduction of aptasensors, broadening their use for HER2 analysis. This novel approach of using the same aptamer as biosensor ligand and as transducer can be universally extended to other aptasensors for a wide array of biodetection applications. Moreover, electric currents generated by DNA or other nucleic acids can be used in molecular electronics or implanted devices for both power generation and measurement of output.

  2. High current transistor pulse generator

    SciTech Connect

    Nesterov, V.; Cassel, R.

    1991-05-01

    A solid state pulse generator capable of delivering high current trapezoidally shaped pulses into an inductive load has been developed at SLAC. Energy stored in the capacitor bank of the pulse generator is switched to the load through a pair of Darlington transistors. A combination of diodes and Darlington transistors is used to obtain trapezoidal or triangular shaped current pulses into an inductive load and to recover the remaining energy in the same capacitor bank without reversing capacitor voltage. The transistors work in the switch mode, and the power losses are low. The rack mounted pulse generators presently used at SLAC contain a 660 microfarad storage capacitor bank and can deliver 400 amps at 800 volts into inductive loads up to 3 mH. The pulse generators are used in several different power systems, including pulse to pulse bipolar power supplies and in application with current pulses distributed into different inductive loads. The current amplitude and discharge time are controlled by the central computer system through a specially developed multichannel controller. Several years of operation with the pulse generators have proven their consistent performance and reliability. 8 figs.

  3. Current responsive devices for synchronous generators

    DOEpatents

    Karlicek, R.F.

    1983-09-27

    A device for detecting current imbalance between phases of a polyphase alternating current generator. A detector responds to the maximum peak current in the generator, and detecting means generates an output for each phase proportional to the peak current of each phase. Comparing means generates an output when the maximum peak current exceeds the phase peak current. 11 figs.

  4. Current responsive devices for synchronous generators

    DOEpatents

    Karlicek, Robert F.

    1983-01-01

    A device for detecting current imbalance between phases of a polyphase alternating current generator. A detector responds to the maximum peak current in the generator, and detecting means generates an output for each phase proportional to the peak current of each phase. Comparing means generates an output when the maximum peak current exceeds the phase peak current.

  5. 40 CFR 279.32 - Used oil aggregation points owned by the generator.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the generator. 279.32 Section 279.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Collection Centers and Aggregation Points § 279.32 Used oil aggregation points owned by the generator. (a... aggregation points must comply with the generator standards in subpart C of this part....

  6. 40 CFR 279.32 - Used oil aggregation points owned by the generator.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the generator. 279.32 Section 279.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Collection Centers and Aggregation Points § 279.32 Used oil aggregation points owned by the generator. (a... aggregation points must comply with the generator standards in subpart C of this part....

  7. 40 CFR 279.32 - Used oil aggregation points owned by the generator.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the generator. 279.32 Section 279.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Collection Centers and Aggregation Points § 279.32 Used oil aggregation points owned by the generator. (a... aggregation points must comply with the generator standards in subpart C of this part....

  8. 40 CFR 279.32 - Used oil aggregation points owned by the generator.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the generator. 279.32 Section 279.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Collection Centers and Aggregation Points § 279.32 Used oil aggregation points owned by the generator. (a... aggregation points must comply with the generator standards in subpart C of this part....

  9. 40 CFR 279.32 - Used oil aggregation points owned by the generator.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the generator. 279.32 Section 279.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Collection Centers and Aggregation Points § 279.32 Used oil aggregation points owned by the generator. (a... aggregation points must comply with the generator standards in subpart C of this part....

  10. Aggregate crash prediction models: introducing crash generation concept.

    PubMed

    Naderan, Ali; Shahi, Jalil

    2010-01-01

    Safety conscious planning is a new proactive approach towards understanding crashes. It requires a planning-level decision-support tool to facilitate proactive approach to assessing safety effects of alternative urban planning scenarios. The objective of this research study is to develop a series of aggregate crash prediction models (ACPM) that are consistent with the trip generation step of the conventional four-step demand models. The concept of crash generation models (CGMs) is introduced utilizing trip generation data in a generalized linear regression with the assumption of a negative binomial error structure. The relationship of crash frequencies in traffic analysis zones (TAZ) and number of trips generated by purpose is investigated. This translates into immediate checking of the impact of future trip generations on crash frequencies in comprehensive transportation-planning studies (i.e. ability to forecast crashes at each time-step trips are being forecasted). A good relation was seen between crash frequency and number of trips produced/attracted by purpose per TAZ.

  11. A compact submicrosecond, high current generator.

    PubMed

    Kovalchuk, B M; Kharlov, A V; Zorin, V B; Zherlitsyn, A A

    2009-08-01

    Pulsed current generator was developed for experiments with current carrying pulsed plasma. Main parts of the generator are capacitor bank, low inductive current driving lines, and central load part. Generator consists of four identical sections, connected in parallel to one load. Capacitor bank is assembled from 24 capacitor blocks (100 kV, 80 nF), connected in parallel. It stores 9.6 kJ at 100 kV charging voltage. Each capacitor block incorporates a multigap spark switch, which is able to commute by six parallel channels. Switches operate in dry air at atmospheric pressure. The generator was tested with an inductive load and a liner load. At 17.5 nH inductive load and 100 kV of charging voltage it provides 650 kA of current amplitude with 390 ns rise time with 0.6 ohms damping resistors in discharge circuit of each capacitor block. The net generator inductance without a load was optimized to be as low as 15 nH, which results in extremely low impedance of the generator (approximately 0.08 ohms). It ensures effective energy coupling with a low impedance load such as Z pinch. The generator operates reliably without any adjustments in 70-100 kV range of charging voltage. Jitter in delay between output pulse and triggering pulse is less than 5 ns at 70-100 kV charging voltage. Operation and handling are very simple, because no oil or purified gases are required for the generator. The generator has dimensions 5.24x1.2x0.18 m(3) and total weight about 1400 kg, thus manifesting itself as simple, robust, and cost effective apparatus.

  12. High current high accuracy IGBT pulse generator

    SciTech Connect

    Nesterov, V.V.; Donaldson, A.R.

    1995-05-01

    A solid state pulse generator capable of delivering high current triangular or trapezoidal pulses into an inductive load has been developed at SLAC. Energy stored in a capacitor bank of the pulse generator is switched to the load through a pair of insulated gate bipolar transistors (IGBT). The circuit can then recover the remaining energy and transfer it back to the capacitor bank without reversing the capacitor voltage. A third IGBT device is employed to control the initial charge to the capacitor bank, a command charging technique, and to compensate for pulse to pulse power losses. The rack mounted pulse generator contains a 525 {mu}F capacitor bank. It can deliver 500 A at 900V into inductive loads up to 3 mH. The current amplitude and discharge time are controlled to 0.02% accuracy by a precision controller through the SLAC central computer system. This pulse generator drives a series pair of extraction dipoles.

  13. Recombination-generation currents in degenerate semiconductors

    NASA Technical Reports Server (NTRS)

    Von Roos, O.

    1978-01-01

    The classical Shockley-Read-Hall theory of free carrier recombination and generation via traps is extended to degenerate semiconductors. A concise and simple expression is found which avoids completely the concept of a Fermi level, a concept which is alien to nonequilibrium situations. Assumptions made in deriving the recombination generation current are carefully delineated and are found to be basically identical to those made in the original theory applicable to nondegenerate semiconductors.

  14. Current generation by phased injection of pellets

    SciTech Connect

    Fisch, N.J.

    1983-08-01

    By phasing the injection of frozen pellets into a tokamak plasma, it is possible to generate current. The current occurs when the electron flux to individual members of an array of pellets is asymmetric with respect to the magnetic field. The utility of this method for tokamak reactors, however, is unclear; the current, even though free in a pellet-fueled reactor, may not be large enough to be worth the trouble. Uncertainty as to the utility of this method is, in part, due to uncertainty as to proper modeling of the one-pellet problem.

  15. Generating nanoscale aggregates from colloidal nanoparticles by various aerosol spray techniques

    SciTech Connect

    Mahurin, Shannon Mark; Cheng, Mengdawn

    2007-01-01

    Growing interest in the environmental and health effects of engineered nanostructured materials requires accurate control of cluster morphology and size in order to make valid interpretations of nanomaterial toxicity. We report the comparison of three methods for the generation of aggregated uniform polystyrene latex (PSL) nanospheres from a colloidal suspension. Atomization, ultrasonic generation and electrospray, which utilize distinct mechanisms for the formation of liquid droplets from a PSL colloidal suspension, are explored as potential methods for nanostructured material synthesis. Electrospray produced isolated PSL particles most suited for use in experiments involving exposure to non-aggregated nanoparticles. Though producing the largest cluster size, ultrasonic generation proved to be a relatively straightforward process for reproducibly generating nanoparticle aggregates. Further advantages and disadvantages of each method are presented in relation to future toxicology experiments.

  16. Generation and Exploitation of Aggregation Abstractions for Scheduling and Resource Allocation

    NASA Technical Reports Server (NTRS)

    Linden, Theodore A.; Lowry, Michael R.

    1992-01-01

    Our research is investigating abstraction of computational theories for scheduling and resource allocation. These theories are represented in a variant of first order predicate calculus, parameterized multisorted logic, that facilitates specification of large problems. A particular problem is conceptually stated as a set of ground sentences that are consistent with a quantified theory. We are mainly investigating the automated generation of aggregation abstractions and approximations in which detailed resource allocation constraints are replaced by constraints between aggregate demand and capacity. We are also investigating the interaction of aggregation abstractions with the more thoroughly investigated abstractions of weakening operator preconditions. The purpose of the theories for aggregated demand/capacity is threefold: first, to answer queries about aggregate properties, such as gross feasibility; second, to reduce computational costs by using the solution of aggregate problems to guide the solution of detailed problems; and third, to facilitate reformulating theories to approximate problems for which there are efficient problem solving methods. We also describe novel methods for exploiting aggregation abstractions.

  17. Sequence-Specific Protein Aggregation Generates Defined Protein Knockdowns in Plants1[OPEN

    PubMed Central

    Vuylsteke, Marnik; Aesaert, Stijn; Rombaut, Debbie; De Smet, Frederik; Xu, Jie; Van Lijsebettens, Mieke; Rousseau, Frederic

    2016-01-01

    Protein aggregation is determined by short (5–15 amino acids) aggregation-prone regions (APRs) of the polypeptide sequence that self-associate in a specific manner to form β-structured inclusions. Here, we demonstrate that the sequence specificity of APRs can be exploited to selectively knock down proteins with different localization and function in plants. Synthetic aggregation-prone peptides derived from the APRs of either the negative regulators of the brassinosteroid (BR) signaling, the glycogen synthase kinase 3/Arabidopsis SHAGGY-like kinases (GSK3/ASKs), or the starch-degrading enzyme α-glucan water dikinase were designed. Stable expression of the APRs in Arabidopsis (Arabidopsis thaliana) and maize (Zea mays) induced aggregation of the target proteins, giving rise to plants displaying constitutive BR responses and increased starch content, respectively. Overall, we show that the sequence specificity of APRs can be harnessed to generate aggregation-associated phenotypes in a targeted manner in different subcellular compartments. This study points toward the potential application of induced targeted aggregation as a useful tool to knock down protein functions in plants and, especially, to generate beneficial traits in crops. PMID:27208282

  18. Laboratory Experiments of Rip Current Generation

    NASA Astrophysics Data System (ADS)

    Garnier, R.; Coco, G.; Lomonaco, P.; Dalrymple, R. A.; Alvarez, A.; Gonzalez, M.; Medina, R.

    2014-12-01

    The hypothesis of rip current generation from purely hydrodynamic processes is here investigated through laboratory experiments. The experiments have been performed at the Cantabria Coastal and Ocean Basin (CCOB) with a segmented wavemaker consisting of 64 waveboards. The basin measures 25m in the cross-shore and 32m in the alongshore direction and the water depth at the wavemaker is 1m. A concrete plane sloping (1:5) beach has been built in the opposite side of the wave machine, its toe is 15m from the waveboards. Reflective lateral walls covered the full length of the basin. The set of instruments consists of 33 wave gauges deployed along two longshore and two cross-shore transects, 7 acoustic Doppler velocimeters and 15 run-up wires. Furthermore a set of two cameras has been synchronized with the data acquisition system. Two types of experiments have been performed to specifically study the generation of rip currents under wave group forcing. First, similarly to the experiments of Fowler and Dalrymple (Proc. 22nd Int. Conf. Coast. Eng.,1990), two intersecting wave trains with opposite directions have been imposed. They give rise to the formation of a non-migrating rip current system with a wavelength that depends on wave frequency and direction. Second, single wave trains with alongshore periodic amplitude attenuation have been imposed. Although the attenuation has been set such that the incident wave field has the same envelope as in the first type of experiments, the rip current system differs due to diffraction and interference processes. The results for different wave conditions (maximum incident wave height from 0.2m to 0.4m, wave period from 1.4s to 2s) will be presented and the intensity of the rip currents will be compared to the alongshore variation in wave set-up. This research is part of the ANIMO project funded by the Spanish Government under contract BIA2012-36822.

  19. Generation of urban road dust from anti-skid and asphalt concrete aggregates.

    PubMed

    Tervahattu, Heikki; Kupiainen, Kaarle J; Räisänen, Mika; Mäkelä, Timo; Hillamo, Risto

    2006-04-30

    Road dust forms an important component of airborne particulate matter in urban areas. In many winter cities the use of anti-skid aggregates and studded tires enhance the generation of mineral particles. The abrasion particles dominate the PM10 during springtime when the material deposited in snow is resuspended. This paper summarizes the results from three test series performed in a test facility to assess the factors that affect the generation of abrasion components of road dust. Concentrations, mass size distribution and composition of the particles were studied. Over 90% of the particles were aluminosilicates from either anti-skid or asphalt concrete aggregates. Mineral particles were observed mainly in the PM10 fraction, the fine fraction being 12% and submicron size being 6% of PM10 mass. The PM10 concentrations increased as a function of the amount of anti-skid aggregate dispersed. The use of anti-skid aggregate increased substantially the amount of PM10 originated from the asphalt concrete. It was concluded that anti-skid aggregate grains contribute to pavement wear. The particle size distribution of the anti-skid aggregates had great impact on PM10 emissions which were additionally enhanced by studded tires, modal composition, and texture of anti-skid aggregates. The results emphasize the interaction of tires, anti-skid aggregate, and asphalt concrete pavement in the production of dust emissions. They all must be taken into account when measures to reduce road dust are considered. The winter maintenance and springtime cleaning must be performed properly with methods which are efficient in reducing PM10 dust.

  20. Electric current generation in distorted graphene

    NASA Astrophysics Data System (ADS)

    Mizher, Ana Julia; Raya, Alfredo; Villavicencio, Cristián

    2016-12-01

    Graphene-like materials can be effectively described by quantum electrodynamics in (2+1) dimensions, QED3. In a pristine state, these systems exhibit a symmetry between the nonequivalent Dirac points in the honeycomb lattice. Realistic samples which include distortions and crystalline anisotropies are considered through mass gaps of topological and dynamical nature. In this work, we show that the incorporation of an in-plane uniform external magnetic field on this pseudochiral asymmetric configuration generates a nondissipative electric current aligned with the magnetic field: The pseudochiral magnetic effect (PCME). This scenario resembles the chiral magnetic effect in quantum chromodynamics (QCD).

  1. Configuration and Generation of Substorm Current Wedge

    NASA Astrophysics Data System (ADS)

    Chu, Xiangning

    The substorm current wedge (SCW), a core element of substorm dynamics coupling the magnetotail to the ionosphere, is crucial in understanding substorms. It has been suggested that the field-aligned currents (FACs) in the SCW are caused by either pressure gradients or flow vortices, or both. Our understanding of FAC generations is based predominately on numerical simulations, because it has not been possible to organize spacecraft observations in a coordinate system determined by the SCW. This dissertation develops an empirical inversion model of the current wedge and inverts midlatitude magnetometer data to obtain the parameters of the current wedge for three solar cycles. This database enables statistical data analysis of spacecraft plasma and magnetic field observations relative to the SCW coordinate. In chapter 2, a new midlatitude positive bay (MPB) index is developed and calculated for three solar cycles of data. The MPB index is processed to determine the substorm onset time, which is shown to correspond to the auroral breakup onset with at most 1-2 minutes difference. Substorm occurrence rate is found to depend on solar wind speed while substorm duration is rather constant, suggesting that substorm process has an intrinsic pattern independent of external driving. In chapter 3, an SCW inversion technique is developed to determine the strength and locations of the FACs in an SCW. The inversion parameters for FAC strength and location, and ring current strength are validated by comparison with other measurements. In chapter 4, the connection between earthward flows and auroral poleward expansion is examined using improved mapping, obtained from a newly-developed dynamic magnetospheric model by superimposing a standard magnetospheric field model with substorm current wedge obtained from the inversion technique. It is shown that the ionospheric projection of flows observed at a fixed point in the equatorial plane map to the bright aurora as it expands poleward

  2. Particle-bubble aggregate stability on static bubble generated by single nozzle on flotation process

    NASA Astrophysics Data System (ADS)

    Warjito, Harinaldi, Setyantono, Manus; Siregar, Sahala D.

    2016-06-01

    There are three sub-processes on flotation. These processes are intervening liquid film into critical thickness, rupture of liquid film forming three phase contact line, and expansion three phase contact line forming aggregate stability. Aggregate stability factor contribute to determine flotation efficiency. Aggregate stability has some important factors such as reagent and particle geometry. This research focussed on to understand effect of particle geometry to aggregate stability. Experimental setup consists of 9 x 9 x26 cm flotation column made of glass, bubble generator, particle feeding system, and high speed video camera. Bubble generator made from single nozzle with 0.3 mm diameter attached to programmable syringe pump. Particle feeding system made of pipette. Particle used in this research is taken from open pit Grasberg in Timika, Papua. Particle has sub-angular geometry and its size varies from 38 to 300 µm. Bubble-particle interaction are recorded using high speed video camera. Recordings from high speed video camera analyzed using image processing software. Experiment result shows that aggregate particle-bubble and induction time depends on particle size. Small particle (38-106 µm) has long induction time and able to rupture liquid film and also forming three phase contact line. Big particle (150-300 µm) has short induction time, so it unable to attach with bubble easily. This phenomenon is caused by apparent gravity work on particle-bubble interaction. Apparent gravity worked during particle sliding on bubble surface experience increase and reached its maximum magnitude at bubble equator. After particle passed bubble equator, apparent gravity force experience decrease. In conclusion particle size from 38-300 µm can form stable aggregate if particle attached with bubble in certain condition.

  3. Generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos.

    PubMed

    Artus, Jérôme; Hadjantonakis, Anna-Katerina

    2011-01-01

    From the hybrid creatures of the Greek and Egyptian mythologies, the concept of the chimera has evolved and, in modern day biology, refers to an organism comprises of at least two populations of genetically distinct cells. Mouse chimeras have proven an invaluable tool for the generation of genetically modified strains. In addition, chimeras have been extensively used in developmental biology as a powerful tool to analyze the phenotype of specific mutations, to attribute function to gene products and to address the question of cell autonomy versus noncell autonomy of gene function. This chapter describes a simple and economical technique used to generate mouse chimeras by embryo aggregation. Multiple aggregation combinations are described each of which can be tailored to answer particular biological questions.

  4. 12. GENERATING UNIT NO. 2, WITH (LR) CONTINUOUS CURRENT EXCITER, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. GENERATING UNIT NO. 2, WITH (L-R) CONTINUOUS CURRENT EXCITER, ALTERNATING CURRENT GENERATOR, AND TURBINE GOVERNOR. VIEW TO SOUTH. - Cooke Hydroelectric Plant, Powerhouse, Cook Dam Road at Au Sable River, Oscoda, Iosco County, MI

  5. Currents generated by lower hybrid waves

    SciTech Connect

    McWilliams, R.; Motley, R.W.

    1981-04-01

    Electron currents can be driven in a linear plasma by the absorption of lower hybrid waves excited primarily in one direction. Current-drive has been demonstrated both for collisional and resonant-electron absorption. The magnitude of the excited currents is compared with the predictions from an electron kinetic equation with a Lorentz collision operator in the regime k/sub parallel to/v/sub te//..omega..<<1.

  6. Turbidity currents generated by Hurricane Iwa

    USGS Publications Warehouse

    Dengler, A.T.; Wilde, P.; Noda, E.K.; Normark, W.R.

    1984-01-01

    Off southwest Oahu, Hawaii, an array of current sensors recorded four successive episodes of downslope displacement associated with high-speed near-bottom currents of up to 200 cm/s and elevated water temperatures. These episodes coincided with the maximum storm effects of hurricane Iwa. Sensors from four moorings recorded increases in depth of as much as 220 m, implying downslope movement of as much as 2.4 km at speeds up to 300 cm/s. A succession of slope failures at or above the 110-m shelf break, each resulting in a turbidity current event, is the favored explanation. ?? 1984 Springer-Verlag New York Inc.

  7. Optimization of Gear Ratio in the Tidal Current Generation System based on Generated Energy

    NASA Astrophysics Data System (ADS)

    Naoi, Kazuhisa; Shiono, Mitsuhiro; Suzuki, Katsuyuki

    It is possible to predict generating power of the tidal current generation, because of the tidal current's periodicity. Tidal current generation is more advantageous than other renewable energy sources, when the tidal current generation system is connected to the power system and operated. In this paper, we propose a method used to optimize the gear ratio and generator capacity, that is fundamental design items in the tidal current generation system which is composed of Darrieus type water turbine and squirrel-cage induction generator coupled with gear. The proposed method is applied to the tidal current generation system including the most large-sized turbine that we have developed and studied. This paper shows optimum gear ratio and generator capacity that make generated energy maximum, and verify effectiveness of the proposed method. The paper also proposes a method of selecting maximum generating current velocity in order to reduce the generator capacity, from the viewpoint of economics.

  8. Where the wild things are: predicting hotspots of seabird aggregations in the California Current System.

    PubMed

    Nur, Nadav; Jahncke, Jaime; Herzog, Mark P; Howar, Julie; Hyrenbach, K David; Zamon, Jeannette E; Ainley, David G; Wiens, John A; Morgan, Ken; Ballance, Lisa T; Stralberg, Diana

    2011-09-01

    Marine protected areas (MPAs) provide an important tool for conservation of marine ecosystems. To be most effective, these areas should be strategically located in a manner that supports ecosystem function. To inform marine spatial planning and support strategic establishment of MPAs within the California Current System, we identified areas predicted to support multispecies aggregations of seabirds ("hotspots"). We developed habitat-association models for 16 species using information from at-sea observations collected over an 11-year period (1997-2008), bathymetric data, and remotely sensed oceanographic data for an area from north of Vancouver Island, Canada, to the USA/Mexico border and seaward 600 km from the coast. This approach enabled us to predict distribution and abundance of seabirds even in areas of few or no surveys. We developed single-species predictive models using a machine-learning algorithm: bagged decision trees. Single-species predictions were then combined to identify potential hotspots of seabird aggregation, using three criteria: (1) overall abundance among species, (2) importance of specific areas ("core areas") to individual species, and (3) predicted persistence of hotspots across years. Model predictions were applied to the entire California Current for four seasons (represented by February, May, July, and October) in each of 11 years. Overall, bathymetric variables were often important predictive variables, whereas oceanographic variables derived from remotely sensed data were generally less important. Predicted hotspots often aligned with currently protected areas (e.g., National Marine Sanctuaries), but we also identified potential hotspots in Northern California/Southern Oregon (from Cape Mendocino to Heceta Bank), Southern California (adjacent to the Channel Islands), and adjacent to Vancouver Island, British Columbia, that are not currently included in protected areas. Prioritization and identification of multispecies hotspots will

  9. Where the wild things are: Predicting hotspots of seabird aggregations in the California Current System

    USGS Publications Warehouse

    Nur, N.; Jahncke, J.; Herzog, M.P.; Howar, J.; Hyrenbach, K.D.; Zamon, J.E.; Ainley, D.G.; Wiens, J.A.; Morgan, K.; Balance, L.T.; Stralberg, D.

    2011-01-01

    Marine Protected Areas (MPAs) provide an important tool for conservation of marine ecosystems. To be most effective, these areas should be strategically located in a manner that supports ecosystem function. To inform marine spatial planning and support strategic establishment of MPAs within the California Current System, we identified areas predicted to support multispecies aggregations of seabirds ("hotspot????). We developed habitat-association models for 16 species using information from at-sea observations collected over an 11-year period (1997-2008), bathymetric data, and remotely sensed oceanographic data for an area from north of Vancouver Island, Canada, to the USA/Mexico border and seaward 600 km from the coast. This approach enabled us to predict distribution and abundance of seabirds even in areas of few or no surveys. We developed single-species predictive models using a machine-learning algorithm: bagged decision trees. Single-species predictions were then combined to identify potential hotspots of seabird aggregation, using three criteria: (1) overall abundance among species, (2) importance of specific areas ("core area????) to individual species, and (3) predicted persistence of hotspots across years. Model predictions were applied to the entire California Current for four seasons (represented by February, May, July, and October) in each of 11 years. Overall, bathymetric variables were often important predictive variables, whereas oceanographic variables derived from remotely sensed data were generally less important. Predicted hotspots often aligned with currently protected areas (e.g., National Marine Sanctuaries), but we also identified potential hotspots in Northern California/Southern Oregon (from Cape Mendocino to Heceta Bank), Southern California (adjacent to the Channel Islands), and adjacent to Vancouver Island, British Columbia, that are not currently included in protected areas. Prioritization and identification of multispecies hotspots

  10. The generation of current from hydrogen

    NASA Astrophysics Data System (ADS)

    Sternfeld, H. J.; Wojkowsky, H.; Wolfmueller, K.

    1981-11-01

    Factors regarding the storage of electrical energy and approaches to meet peak loads demands will become increasingly important in the future. A chemical storage of electrical energy in the form of hydrogen appears to offer a suitable approach to satisfy requirements related to these trends. For an implementation of such an approach, it will be necessary to solve the problem of an economical generation of electrical power from hydrogen. Procedures for such a generation of electric power can be divided into two categories, which are related to a use of fuel cells and an employment of steam or gas turbine processes. Suitable fuel cells can be based on a use of hydrogen and oxygen or an employment of hydrogen and air. The use of the power generation procedures of the second category involves a primary transformation of the chemical energy of the fuel into heat. A description is presented of an evaluation study regarding the different types of power stations. Attention is given to a possible technological employment of steam generators based on the use of hydrogen and oxygen in the 1980's.

  11. Organized Aggregation of Porphyrins in Lipid Bilayers for Third Harmonic Generation Microscopy.

    PubMed

    Cui, Liyang; Tokarz, Danielle; Cisek, Richard; Ng, Kenneth K; Wang, Fan; Chen, Juan; Barzda, Virginijus; Zheng, Gang

    2015-11-16

    Nonlinear optical microscopy has become a powerful tool for high-resolution imaging of cellular and subcellular composition, morphology, and interactions because of its high spatial resolution, deep penetration, and low photo-damage to tissue. Developing specific harmonic probes is essential for exploiting nonlinear microscopic imaging for biomedical applications. We report an organized aggregate of porphyrins (OAP) that formed within lipidic nanoparticles showing fingerprint spectroscopic properties, structure-associated second harmonic generation, and superradiant third harmonic generation. The OAP facilitated harmonic microscopic imaging of living cells with significantly enhanced contrast. The structure-dependent switch between harmonic (OAP-intact) and fluorescence (OAP-disrupted) generation enabled real-time multi-modality imaging of the cellular fate of nanoparticles. Robustly produced under various conditions and easily incorporated into pre-formed lipid nanovesicles, OAP provides a biocompatible nanoplatform for harmonic imaging.

  12. An Intracellular Arrangement of Histoplasma capsulatum Yeast-Aggregates Generates Nuclear Damage to the Cultured Murine Alveolar Macrophages

    PubMed Central

    Pitangui, Nayla de Souza; Sardi, Janaina de Cássia Orlandi; Voltan, Aline R.; dos Santos, Claudia T.; da Silva, Julhiany de Fátima; da Silva, Rosangela A. M.; Souza, Felipe O.; Soares, Christiane P.; Rodríguez-Arellanes, Gabriela; Taylor, Maria Lucia; Mendes-Giannini, Maria J. S.; Fusco-Almeida, Ana M.

    2016-01-01

    Histoplasma capsulatum is responsible for a human systemic mycosis that primarily affects lung tissue. Macrophages are the major effector cells in humans that respond to the fungus, and the development of respiratory disease depends on the ability of Histoplasma yeast cells to survive and replicate within alveolar macrophages. Therefore, the interaction between macrophages and H. capsulatum is a decisive step in the yeast dissemination into host tissues. Although the role played by components of cell-mediated immunity in the host's defense system and the mechanisms used by the pathogen to evade the host immune response are well understood, knowledge regarding the effects induced by H. capsulatum in host cells at the nuclear level is limited. According to the present findings, H. capsulatum yeast cells display a unique architectural arrangement during the intracellular infection of cultured murine alveolar macrophages, characterized as a formation of aggregates that seem to surround the host cell nucleus, resembling a “crown.” This extranuclear organization of yeast-aggregates generates damage on the nucleus of the host cell, producing DNA fragmentation and inducing apoptosis, even though the yeast cells are not located inside the nucleus and do not trigger changes in nuclear proteins. The current study highlights a singular intracellular arrangement of H. capsulatum yeast near to the nucleus of infected murine alveolar macrophages that may contribute to the yeast's persistence under intracellular conditions, since this fungal pathogen may display different strategies to prevent elimination by the host's phagocytic mechanisms. PMID:26793172

  13. Direct Generation of Electric Currents from Flowing Neutral Ionic Solutions

    PubMed Central

    2013-01-01

    We have discovered a new method of generating electric currents, directly from high pressure-induced flow of neutral ionic solutions. The mechanism is that the cations and anions have different flow velocities, if their atomic masses are dramatically different, due to different accelerations generated from the high applied pressure. The generated electric current is very sensitive to the strengths of the applied pressure, and it might be potentially used for detection of atomic masses and pressures. PMID:24187520

  14. Ultrahigh-throughput Generation and Characterization of Cellular Aggregates in Laser-ablated Microwells of Poly(dimethylsiloxane)

    PubMed Central

    Albritton, Jacob L.; Roybal, Jonathon D.; Paulsen, Samantha J.; Calafat, Nick; Flores-Zaher, Jose A.; Farach-Carson, Mary C.; Gibbons, Don L.; Miller, Jordan S.

    2016-01-01

    Aggregates of cells, also known as multicellular aggregates (MCAs), have been used as microscale tissues in the fields of cancer biology, regenerative medicine, and developmental biology for many decades. However, small MCAs (fewer than 100 cells per aggregate) have remained challenging to manufacture in large quantities at high uniformity. Forced aggregation into microwells offers a promising solution for forming consistent aggregates, but commercial sources of microwells are expensive, complicated to manufacture, or lack the surface packing densities that would significantly improve MCA production. To address these concerns, we custom-modified a commercial laser cutter to provide complete control over laser ablation and directly generate microwells in a poly(dimethylsiloxane) (PDMS) substrate. We achieved ultra rapid microwell production speeds (>50,000 microwells/hr) at high areal packing densities (1,800 microwells/cm2) and over large surface areas for cell culture (60 cm2). Variation of the PDMS substrate distance from the laser focal plane during ablation allowed for the generation of microwells with a variety of sizes, contours, and aspect ratios. Casting of high-fidelity microneedle masters in polyurethane allowed for non-ablative microwell reproduction through replica molding. MCAs of human bone marrow derived mesenchymal stem cells (hMSCs), murine 344SQ metastatic adenocarcinoma cells, and human C4-2 prostate cancer cells were generated in our system with high uniformity within 24 hours, and computer vision software aided in the ultra-high-throughput analysis of harvested aggregates. Moreover, MCAs maintained invasive capabilities in 3D migration assays. In particular, 344SQ MCAs demonstrated epithelial lumen formation on Matrigel, and underwent EMT and invasion in the presence of TGF-β. We expect this technique to find broad utility in the generation and cultivation of cancer cell aggregates, primary cell aggregates, and embryoid bodies. PMID:26998251

  15. Generation of Pure Bulk Valley Current in Graphene

    NASA Astrophysics Data System (ADS)

    Jiang, Yongjin; Low, Tony; Chang, Kai; Katsnelson, Mikhail I.; Guinea, Francisco

    2013-01-01

    The generation of valley current is a fundamental goal in graphene valleytronics but no practical ways of its realization are known yet. We propose a workable scheme for the generation of bulk valley current in a graphene mechanical resonator through adiabatic cyclic deformations of the strains and a chemical potential in the suspended region. The accompanied strain gauge fields can break the spatial mirror symmetry of the problem within each of the two inequivalent valleys, leading to a finite valley current due to quantum pumping. An all-electrical measurement configuration is designed to detect the novel state with pure bulk valley currents.

  16. Current distribution and nonuniformity effects in MHD disk generators

    NASA Astrophysics Data System (ADS)

    Roseman, D. F.

    1982-08-01

    Current distribution and nonuniformity effects in combustion driven MHD disk generators were studied. The importance of these phenomena to baseload power generation was investigated. The peg wall construction allowed current and voltage distributions to be measured. The channel was operated with plasma temperatures up to 2750 K and magnetic field strengths up to 5.5 Tesla. The magnitudes of the currents and voltages were reduced by significant loss mechanisms, primarily electrode losses and current leakage through the wall caused by potassium seed penetration of the castable ceramic between the pegs. A simple circuit model accounting for these losses was developed to be compared with analytical calculations. Under normal uniform electrical loading the distributions measured in the channel were uniform as expected. Nonuniform electrical loading was used to produce and measure effects on the current distribution that occur only in the presence of high magnetic fields as required for MHD power generation.

  17. A fluid mechanical model for current-generating-feeding jellyfish

    NASA Astrophysics Data System (ADS)

    Peng, Jifeng; Dabiri, John

    2008-11-01

    Many jellyfish species, e.g. moon jellyfish Aurelia aurita, use body motion to generate fluid currents which carry their prey to the vicinity of their capture appendages. In this study, a model was developed to understand the fluid mechanics for this current-generating-feeding mode of jellyfish. The flow generated by free-swimming Aurelia aurita was measured using digital particle image velocimetry. The dynamics of prey (e.g., brine shrimp Artemia) in the flow field were described by a modified Maxey-Riley equation which takes into consideration the inertia of prey and the escape forces, which prey exert in the presence of predator. A Lagrangian analysis was used to identify the region of the flow in which prey can be captured by the jellyfish and the clearance rate was quantified. The study provides a new methodology to study biological current-generating-feeding and the transport and mixing of particles in fluid flow in general.

  18. Dying Flow Bursts as Generators of the Substorm Current Wedge

    NASA Astrophysics Data System (ADS)

    Haerendel, Gerhard

    2016-07-01

    Many theories or conjectures exist on the driver of the substorm current wedge, e.g. rerouting of the tail current, current disruption, flow braking, vortex formation, and current sheet collapse. Magnitude, spatial scale, and temporal development of the related magnetic perturbations suggest that the generator is related to the interaction of the flow bursts with the dipolar magnetosphere after onset of reconnection in the near-Earth tail. The question remains whether it is the flow energy that feeds the wedge current or the internal energy of the arriving plasma. In this presentation I argue for the latter. The current generation is attributed to the force exerted by the dipolarized magnetic field of the flow bursts on the preceding layer of high-beta plasma after flow braking. The generator current is the grad-B current at the outer boundary of the compressed high-beta plasma layers. It needs the sequential arrival of several flow bursts to account for duration and magnitude of the ionospheric closure current.

  19. Dying Flow Bursts as Generators of the Substorm Current Wedge

    NASA Astrophysics Data System (ADS)

    Haerendel, G.

    2015-12-01

    Many theories or conjectures exist on the driver of the substorm current wedge, e.g. rerouting of the tail current, current disruption, flow braking, vortex formation, and current sheet collapse. Magnitude, spatial scale, and temporal development of the related magnetic perturbations suggest that the generator is related to the interaction of the flow bursts with the dipolar magnetosphere after onset of reconnection in the near-Earth tail. The question remains whether it is the flow energy that feeds the wedge current or the internal energy of the arriving plasma. In this presentation I argue for the latter. The current generation is attributed to the force exerted by the dipolarized magnetic field of the flow bursts on the preceding layer of high-beta plasma after flow braking. The generator current is the grad-B current at the outer boundary of the compressed high-beta plasma layers. It needs the sequential arrival of several flow bursts to account for duration and magnitude of the ionospheric closure current.

  20. Random parasite encounters coupled with condition-linked immunity of hosts generate parasite aggregation.

    PubMed

    Morrill, André; Forbes, Mark R

    2012-06-01

    Parasite aggregation is viewed as a natural law in parasite-host ecology but is a paradox insofar as parasites should follow the Poisson distribution if hosts are encountered randomly. Much research has focused on whether parasite aggregation in or on hosts is explained by aggregation of infective parasite stages in the environment, or by heterogeneity within host samples in terms of host responses to infection (e.g., through representation of different age classes of hosts). In this paper, we argue that the typically aggregated distributions of parasites may be explained simply. We propose that aggregated distributions can be derived from parasites encountering hosts randomly, but subsequently by parasites being 'lost' from hosts based on condition-linked escape or immunity of hosts. Host condition should be a normally distributed trait even among otherwise homogeneous sets of hosts. Our model shows that mean host condition and variation in host condition have different effects on the different metrics of parasite aggregation. Our model further predicts that as host condition increases, parasites become more aggregated but numbers of attending parasites are reduced overall and this is important for parasite population dynamics. The effects of deviation from random encounter are discussed with respect to the relationship between host condition and final parasite numbers.

  1. Extreme waves generated by modulational instability on adverse currents

    NASA Astrophysics Data System (ADS)

    Ma, Yuxiang; Ma, Xiaozhou; Perlin, Marc; Dong, Guohai

    2013-11-01

    Physical experiments focusing on the propagation of gravity waves of finite depth on adverse currents were implemented to examine their effect on the development of the modulational instability and to study the geometric characteristics of extreme waves. A series of wave trains with varying initial steepness, perturbation frequency, and initial perturbed strength were mechanically generated in a wave-current flume. The present results show that opposing currents can speed the growth of the modulational instability, verifying the previous theory qualitatively. A current-modified nonlinear Schrödinger equation can predict the measured sideband growth rates well for wave trains with lower perturbation frequencies, but overestimated those with higher perturbation frequencies. On the other hand, the limiting steepness of extreme waves measured in the presence of opposing currents was smaller than that measured in quiescent water. Additionally, current strength was found to have limited influence on the geometric properties of extreme waves as well as on their limiting steepness.

  2. Hall current effects in the Lewis magnetohydrodynamic generator

    NASA Technical Reports Server (NTRS)

    Nichols, L. D.; Sovie, R. J.

    1972-01-01

    Data obtained in a magnetohydrodynamic generator are compared with theoretical values calculated by using the Dzung theory. The generator was operated with cesium-seeded argon as the working fluid. The gas temperature varied from 1800 to 2100 K, the gas pressure from 19 to 22 N/sq cm, the Mach number from 0.3 to 0.5, and the magnetic field strength from 0.2 to 1.6 T. The analysis indicates that there is incomplete seed vaporization and that Hall current shorting paths (through the working fluid to ground at both the entrance and exit of the channel) limit generator performance.

  3. Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure.

    PubMed

    Ding, Xuebing; Ma, Mingming; Teng, Junfang; Teng, Robert K F; Zhou, Shuang; Yin, Jingzheng; Fonkem, Ekokobe; Huang, Jason H; Wu, Erxi; Wang, Xuejing

    2015-09-15

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent a continuum of devastating neurodegenerative diseases, characterized by transactive response DNA-binding protein of 43 kDa (TDP-43) aggregates accumulation throughout the nervous system. Despite rapidly emerging evidence suggesting the hypothesis of 'prion-like propagation' of TDP-43 positive inclusion in the regional spread of ALS symptoms, whether and how TDP-43 aggregates spread between cells is not clear. Herein, we established a cerebrospinal fluid (CSF)-cultured cell model to dissect mechanisms governing TDP-43 aggregates formation and propagation. Remarkably, intracellular TDP-43 mislocalization and aggregates were induced in the human glioma U251 cells following exposure to ALS-FTD-CSF but not ALS-CSF and normal control (NC) -CSF for 21 days. The exosomes derived from ALS-FTD-CSF were enriched in TDP-43 C-terminal fragments (CTFs). Incubation of ALS-FTD-CSF induced the increase of mislocated TDP-43 positive exosomes in U251 cells. We further demonstrated that exposure to ALS-FTD-CSF induced the generations of tunneling nanotubes (TNTs)-like structure and exosomes at different stages, which mediated the propagation of TDP-43 aggregates in the cultured U251 cells. Moreover, immunoblotting analyses revealed that abnormal activations of apoptosis and autophagy were induced in U251 cells, following incubation of ALS-CSF and ALS-FTD-CSF. Taken together, our data provide direct evidence that ALS-FTD-CSF has prion-like transmissible properties. TNTs-like structure and exosomes supply the routes for the transfer of TDP-43 aggregates, and selective inhibition of their over-generations may interrupt the progression of TDP-43 proteinopathy.

  4. Training Course for Power Operating Personnel. Lesson No. 6: Alternating-Current Generator Excitation.

    ERIC Educational Resources Information Center

    Department of the Interior, Denver, CO. Engineering and Research Center.

    Subjects covered in this text are controlling the hydroelectric generator, generator excitation, basic principles of direct current generation, direction of current flow, basic alternating current generator, alternating and direct current voltage outputs, converting alternating current to direct current, review of the basic generator and…

  5. Comparing Current Students to a Pre-Millennial Generation: Are They Really Different?

    ERIC Educational Resources Information Center

    Yahr, Michael A.; Schimmel, Kurt

    2013-01-01

    The Millennial generation, also known as Generation Y, has garnered much attention in the print and broadcast media and at academic conferences because of the challenges that they pose to universities and corporations. Aggregate characteristics and preferences of the Millennial generation and of Generation X, their immediate predecessors, have…

  6. Expectation of ozone generation in alternating current corona discharges

    NASA Astrophysics Data System (ADS)

    Yehia, Ashraf; Mizuno, Akira

    2012-03-01

    An analytical study was made in this paper to calculate the ozone generation inside an ac corona discharge reactor. The corona discharges were formed in a coaxial wire-cylinder reactor. The reactor was fed by dry air flowing with constant rates at atmospheric pressure and room temperature and stressed by an ac voltage. Concentration of the ozone generated inside the reactor was measured as a function of the ac corona current under different discharge conditions. An empirical equation was derived from the experimental results for calculating the ozone concentration generated inside the reactor. The results, that have been calculated by using the derived equation, have agreed with the experimental results over the whole range of the investigated parameters. Therefore, the derived equation represents a suitable criterion for expecting the ozone concentration that will generate by ac coronas in dry air fed coaxial wire-cylinder reactors under any discharge conditions in range of the investigated parameters.

  7. Generation of field-aligned current in the auroral zone

    NASA Technical Reports Server (NTRS)

    Okuda, Hideo

    1991-01-01

    Generation of a magnetic field-aligned current in the auroral zone connecting the magnetospheric and ionospheric plasmas has been studied by means of a three dimensional particle simulation model. The model is of a magnetostatic variety appropriate for a low beta plasma in which the high frequency transverse displacement current has been eliminated. The simulation model is highly elongated along the magnetic field lines in order to model a highly elongated flux tube in the auroral zone. An enhanced field-aligned current was generated by injection of a magnetospheric plasma across the auroral zone magnetic field at the center of the model. Such a plasma injection may correspond to a plasmoid injection at the geomagnetic tail associated with magnetic reconnection during a substorm or a transverse plasma flow along the low latitude magnetopause boundary layer. The results of the simulations show that the field-aligned current can be enhanced over the thermal current by a factor of 5 - 10 via such injection. Associated with the enhanced current are the electrostatic ion cyclotron waves and shear Alfven waves excited in the auroral zone.

  8. Spontaneous current generation in the 2SC phase

    SciTech Connect

    Huang Mei

    2006-02-15

    It is found that, except chromomagnetic instability, the gapless 2SC phase also exhibits a paramagnetic response to the perturbation of an external color neutral baryon current. The spontaneously generated baryon current driven by the mismatch is equivalent to the one-plane wave Larkin-Ovchinnikov-Fudde-Ferrell (LOFF) state. We describe the 2SC phase in the nonlinear realization framework, and show that each instability indicates the spontaneous generation of the corresponding pseudo-Nambu-Goldstone current. We show this Nambu-Goldstone currents generation state covers the gluon phase as well as the one-plane wave LOFF state. We further point out that, when the charge neutrality condition is required, there exists a narrow unstable LOFF (Us-LOFF) window, where not only off-diagonal gluons but the diagonal 8th gluon cannot avoid the magnetic instability. We discuss that the diagonal magnetic instability in this Us-LOFF window cannot be cured by an off-diagonal gluon condensate in the color superconducting phase, and it will also show up in some constrained Abelian asymmetric superfluid/superconducting systems.

  9. Meson exchange current (MEC) models in neutrino interaction generators

    SciTech Connect

    Katori, Teppei

    2015-05-15

    Understanding of the so-called 2 particle-2 hole (2p-2h) effect is an urgent program in neutrino interaction physics for current and future oscillation experiments. Such processes are believed to be responsible for the event excesses observed by recent neutrino experiments. The 2p-2h effect is dominated by the meson exchange current (MEC), and is accompanied by a 2-nucleon emission from the primary vertex, instead of a single nucleon emission from the charged-current quasi-elastic (CCQE) interaction. Current and future high resolution experiments can potentially nail down this effect. For this reason, there are world wide efforts to model and implement this process in neutrino interaction simulations. In these proceedings, I would like to describe how this channel is modeled in neutrino interaction generators.

  10. Chirality generated by flows in pseudocyanine dye J-aggregates: revisiting 40 years old reports.

    PubMed

    El-Hachemi, Zoubir; Arteaga, Oriol; Canillas, Adolf; Crusats, Joaquim; Llorens, Joan; Ribo, Josep M

    2011-09-01

    Spontaneous symmetry breaking in J-aggregates of cyanine dyes has a long history in chemical literature. In 1976, Honda and Hada claimed that they had achieved chiral induction (CD) by stirring J-aggregates of pseudocyanine. However, this report is controversial, as the combinations of linear dichroism and birefringence can lead to artifactual circular dichroic signals that are unrelated to molecular chirality. A Mueller matrix spectroscopy study, with an approach for the application of a gradient of the shear rate (solution layer between a rotating and a fixed disk) that differs from the simple vortex stirring used in the original report, shows that true CD can be induced in the sample. The phenomenon is discussed, taking into account the flow dynamics that allows the alignment of the aggregate particles and the gradient of shear rates that determines their folding/torsion, which leads to a chiral excitonic transition.

  11. Leakage Currents and Gas Generation in Advanced Wet Tantalum Capacitors

    NASA Technical Reports Server (NTRS)

    Teverovsky, Alexander

    2015-01-01

    Currently, military grade, established reliability wet tantalum capacitors are among the most reliable parts used for space applications. This has been achieved over the years by extensive testing and improvements in design and materials. However, a rapid insertion of new types of advanced, high volumetric efficiency capacitors in space systems without proper testing and analysis of degradation mechanisms might increase risks of failures. The specifics of leakage currents in wet electrolytic capacitors is that the conduction process is associated with electrolysis of electrolyte and gas generation resulting in building up of internal gas pressure in the parts. The risk associated with excessive leakage currents and increased pressure is greater for high value advanced wet tantalum capacitors, but it has not been properly evaluated yet. In this work, in Part I, leakages currents in various types of tantalum capacitors have been analyzed in a wide range of voltages, temperatures, and time under bias. Gas generation and the level of internal pressure have been calculated in Part II for different case sizes and different hermeticity leak rates to assess maximal allowable leakage currents. Effects related to electrolyte penetration to the glass seal area have been studied and the possibility of failures analyzed in Part III. Recommendations for screening and qualification to reduce risks of failures have been suggested.

  12. Site Selection of Ocean Current Power Generation from Drifter Measurements

    DTIC Science & Technology

    2014-12-01

    Introduction 41 Ocean current power is generated from the kinetic energy of ocean currents with less 42 uncertainty than the wind , wave and solar... power from a fluid’s momentum (e.g. a 48 tidal turbine or wind turbine) can realistically reach an efficiency up to 50% (the Betz 49 limit is a bit...transmission cable system will lie 6-37 km offshore of southeast Florida in 127 about 100-500 m of water. In Taiwan, the anchor system for the deep water of

  13. Efficient Photovoltaic Current Generation at Ferroelectric Domain Walls

    NASA Astrophysics Data System (ADS)

    Seidel, Jan; Fu, Deyi; Yang, Seung-Yeul; Alarcón-Lladó, Esther; Wu, Junqiao; Ramesh, Ramamoorthy; Ager, Joel W., III

    2011-09-01

    We elucidate the mechanism of a newly observed photovoltaic effect which occurs in ferroelectrics with periodic domain structures. Under sufficiently strong illumination, domain walls function as nanoscale generators of the photovoltaic current. The steps in the electrostatic potential function to accumulate electrons and holes on opposite sides of the walls while locally reducing the concentration of the oppositely charged carriers. As a result, the recombination rate adjacent to the walls is reduced, leading to a net diffusion current. In open circuit, photovoltages for periodically ordered domain walls are additive and voltages much larger than the band gap can be generated. The internal quantum efficiency for individual domain walls can be surprisingly high, approaching 10% for above band-gap photons. Although we have found the effect in BiFeO3 films, it should occur in any system with a similar periodic potential.

  14. Practical Application of Eddy Currents Generated by Wind

    NASA Astrophysics Data System (ADS)

    Dirba, I.; Kleperis, J.

    2011-06-01

    When a conductive material is subjected to time-varying magnetic fluxes, eddy (Foucault) currents are generated in it and magnetic field of opposite polarity as the applied one arises. Due to the internal resistance of the conductive material, the eddy currents will be dissipated into heat (Joule heating). Conventional domestic water heaters utilize gas burners or electric resistance heating elements to heat the water in the tank and substantial part of the energy to use for it is wasted. In this paper the origin of electromagnetic induction heat generated by wind turbine in special heat exchange camera connected to water boiler is discussed and material evaluation performed using mathematical modelling (comparing the 2D finite element model with analytical and numerical calculation results).

  15. Submerged electricity generation plane with marine current-driven motors

    DOEpatents

    Dehlsen, James G.P.; Dehlsen, James B.; Fleming, Alexander

    2014-07-01

    An underwater apparatus for generating electric power from ocean currents and deep water tides. A submersible platform including two or more power pods, each having a rotor with fixed-pitch blades, with drivetrains housed in pressure vessels that are connected by a transverse structure providing buoyancy, which can be a wing depressor, hydrofoil, truss, or faired tube. The platform is connected to anchors on the seafloor by forward mooring lines and a vertical mooring line that restricts the depth of the device in the water column. The platform operates using passive, rather than active, depth control. The wing depressor, along with rotor drag loads, ensures the platform seeks the desired operational current velocity. The rotors are directly coupled to a hydraulic pump that drives at least one constant-speed hydraulic-motor generator set and enables hydraulic braking. A fluidic bearing decouples non-torque rotor loads to the main shaft driving the hydraulic pumps.

  16. Performance demonstration requirements for eddy current steam generator tube inspection

    SciTech Connect

    Kurtz, R.J.; Heasler, P.G.; Anderson, C.M.

    1992-10-01

    This paper describes the methodology used for developing performance demonstration tests for steam generator tube eddy current (ET) inspection systems. The methodology is based on statistical design principles. Implementation of a performance demonstration test based on these design principles will help to ensure that field inspection systems have a high probability of detecting and correctly sizing tube degradation. The technical basis for the ET system performance thresholds is presented. Probability of detection and flaw sizing tests are described.

  17. System and method for generating current by selective electron heating

    DOEpatents

    Fisch, Nathaniel J.; Boozer, Allen H.

    1984-01-01

    A system for the generation of toroidal current in a plasma which is prepared in a toroidal magnetic field. The system utilizes the injection of high-frequency waves into the plasma by means of waveguides. The wave frequency and polarization are chosen such that when the waveguides are tilted in a predetermined fashion, the wave energy is absorbed preferentially by electrons traveling in one toroidal direction. The absorption of energy in this manner produces a toroidal electric current even when the injected waves themselves do not have substantial toroidal momentum. This current can be continuously maintained at modest cost in power and may be used to confine the plasma. The system can operate efficiently on fusion grade tokamak plasmas.

  18. Compact high current generator for x-ray radiography

    NASA Astrophysics Data System (ADS)

    Kharlov, A. V.; Kovalchuk, B. M.; Zorin, V. B.

    2006-12-01

    We report here a design of the portable high current generator, which can be used for a row of experiments and applications, including, but not limited to, X pinch, plasma focus, vacuum spark, etc. The X generator consists of the capacitor bank, multigap spark switch, load chamber, and built-in high voltage triggering generator. The capacitor bank consists of 12 General Atomics 35404 type capacitors (20nF, 25nH, 0.2Ω, 100kV). It stores ˜0.8kJ at 80kV charging voltage. Each three capacitors are commuted to a load by the multigap spark switch, which is able to commute by eight parallel channels. Switches operate in ambient air at atmospheric pressure. At 76kV charging voltage the generator provides ˜260kA with 120ns rise time and 5nH inductive load and ˜220kA with 145ns rise time and 10nH. Delay of output pulse relative to high voltage triggering pulse is ˜65ns with 5ns jitter. The dimensions of the generator are 1240×1240×225mm3 and the weight is ˜250kg, and only one high voltage power supply is required as additional equipment for the generator. The generator with a pumping system is placed on area about 0.5m2. Operation and handling are very simple, because no oil nor purified gases are required for the generator. The X generator has been successfully employed for experiments on the Ni X pinch load. X-ray pulse duration (full width at half maximum above 1keV) was about 5ns. Radiation yield Wr⩾500mJ was observed in the 1.2-1.5KeV range and Wr⩾20mJ in the 3-5keV energy range, which is comparable to results, obtained on the nanosecond accelerators. Clearly resolved images of 6μm wire indicate micron level size of hot spot. These results demonstrate possibility of this generator for application for x-ray backlighting.

  19. Chiral current generation in QED by longitudinal photons

    NASA Astrophysics Data System (ADS)

    Acosta Avalo, J. L.; Pérez Rojas, H.

    2016-08-01

    We report the generation of a pseudovector electric current having imbalanced chirality in an electron-positron strongly magnetized gas in QED. It propagates along the external applied magnetic field B as a chiral magnetic effect in QED. It is triggered by a perturbative electric field parallel to B, associated to a pseudovector longitudinal mode propagating along B. An electromagnetic chemical potential was introduced, but our results remain valid even when it vanishes. A nonzero fermion mass was assumed, which is usually considered vanishing in the literature. In the quantum field theory formalism at finite temperature and density, an anomaly relation for the axial current was found for a medium of massive fermions. It bears some analogy to the Adler-Bell-Jackiw anomaly. From the expression for the chiral current in terms of the photon self-energy tensor in a medium, it is obtained that electrons and positrons scattered by longitudinal photons (inside the light cone) contribute to the chiral current, as well as the to pair creation due to longitudinal photons (out of light cone). In the static limit, an electric pseudovector current is obtained in the lowest Landau level.

  20. Current turbine for water pumping and electricity generation

    SciTech Connect

    Mohamed, A.I.E.

    1983-12-01

    This paper describes work on Phase I of ''Mini Hydropower Research and Development Project'' in the Department of Mechanical Engineering, University of Khartoum, in cooperation with the National Council for Research in Sudan. The main purpose of Phase I of the project has been to demonstrate and evaluate the use of water current energy for powering small-scale pumping units and for generating electricity. Power requirements for pumping water for irrigation on typical small land holdings in the Sudan will be of the order of 5-10 Kw. The same sizes of power should sufficiently meet power requirements of home factories for processing farm produce of these lands and of domestic uses. A vertical shaft impulse turbine of innovative design has been built in the Faculty of Engineering, University of Khartoum, to extract energy from water current of canals, rivers or streams. The useful shaft power from the turbine is used for pumping water or electricity generation. The turbine set is suspended from a floating pontoon (made from plastic drums) which is secured in the current by means of two horizontal supporting poles and steel cables. Field trials of a number of model turbine systems are currently being carried out and valuable findings are being obtained about the desirable features to be developed in these machines. However, concrete results are still to be finalized with a view to facilitating analytical design of pump-turbine and generatorturbine systems. Indications are that this work should lead to an efficient, cheap and simple-to-build current turbine. Detailed information on system design and performance are expected to be ready in time for the conference.

  1. Zero-plasma-current equilibria generated by tilted planar coils

    NASA Astrophysics Data System (ADS)

    Li, J.; Israeli, B.; Hammond, K. C.; Volpe, F. A.

    2016-10-01

    It is known that a periodic toroidal arrangement of tilted planar coils, combined with vertical field coils, can generate a helical magnetic field. One question, though, is: is this coil-set a generator or an amplifier of rotational transform? In other words, is a finite plasma-current needed? A numerical scan of coil-currents shows that configurations exist, for which no plasma-current is needed, and yet torsatron plasmas of finite volume can be obtained. The case of six tilted circular coils has been examined in great detail because of its relevance to the CIRCUS device operated by Columbia, a generalization of the two-tilted-coil CNT stellarator, also at Columbia. More axisymmetric configurations featuring a higher number of tilted circular coils are also being investigated. The calculations are performed with the aid of a numerical field-line tracer and the VMEC equilibrium solver, slightly modified to reflect the simplicity of the coil geometry: the coils are not discretized; instead, their field is evaluated by means of analytical expressions. This allows for faster calculations and rapid, fine scans of large parameter spaces.

  2. Effects of black carbon on aggregate stability, runoff generation, splash erosion and slopewash of a clay loam under simulated rainfall

    NASA Astrophysics Data System (ADS)

    Aston, Steve; Doerr, Stefan; Street-Perrott, Alayne

    2013-04-01

    Black (pyrogenic) carbon (BC) was produced from native hardwoods pyrolysed in a ring kiln at ~400° C and ground and sieved to < 2 mm. The BC was then added to a clay loam (sieved to 3.35 mm remaining. After 200 days of incubation, the remainder of each sample was air-dried and sieved to < 5 mm. Each sample was then placed in a square plot and subjected to 40 minutes of simulated rainfall. Runoff and subsurface drainage were measured at 2 minute intervals and runoff was collected at 5 minute intervals to enable subsequent determination of sediment concentrations, sediment yields and erosion rates of soil and BC. Splash cups were placed on each side of the plot to allow measurement of overall splash detachment for each simulation. A BC content of 5g kg-1 did not affect the mean aggregate stability of the clay loam, but a content of 25 g kg-1 led to a decrease in mean aggregate stability of >40%, with a further significant reduction observed when the BC content was 50 g kg-1. There were no statistically significant changes in aggregate stability between 50, 100 and 150 days of incubation for any of the application rates. Results showing the effects of BC on runoff generation, splash erosion and slopewash will also be presented.

  3. Utilization of lignite power generation residues for the production of lightweight aggregates.

    PubMed

    Anagnostopoulos, Iason M; Stivanakis, Victor E

    2009-04-15

    A novel process is proposed for the utilization of lignite combustion solid residues in the production of inflammable lightweight aggregates (LWA). The process consists of two stages, pelletization and sintering, and carbon contained in BA was used as the process fuel. The main residues bottom ash (BA) and fly ash (FA) from Megalopolis power plant were characterized, mixed in different proportions and treated through pelletization and sintering process. Sintering benefits from combustion of BA carbon content and the product is a hardened porous cake. The energy required for achievement of high temperatures, in the range of 1250 degrees C, was offered by carbon combustion and CO(2) evolution is responsible for porous structure formation. Selected physical properties of sintered material relevant to use as lightweight aggregates were determined, including bulk density, porosity and water absorption. Bulk density varies from 0.83 to 0.91 g/cm(3), porosity varies from 60% to 64% and water absorption varies from 66% to 80%. LWA formed is used for the production of lightweight aggregate concrete (LWAC). Thermal conductivity coefficient varies from 0.25 to 0.37 W/mK (lower than maximum limit 0.43 W/mK) and compressive strength varies from 19 to 23 MPa (higher than minimum limit 17 MPa). The results indicate that sintering of lignite combustion residues is an efficient method of utilization of carbon containing BA and production of LWA for structural and insulating purposes. Carbon content of BA is a key factor in LWA production. Finally, this research work comprises the first proposed application for utilization of BA in Greece.

  4. Production efficiencies of U.S. electric generation plants: Effects of data aggregation and greenhouse gas and renewable energy policy

    NASA Astrophysics Data System (ADS)

    Lynes, Melissa Kate

    Over the last few decades there has been a shift in electricity production in the U.S. Renewable energy sources are becoming more widely used. In addition, electric generation plants that use coal inputs are more heavily regulated than a couple decades ago. This shift in electricity production was brought on by changes in federal policy -- a desire for electricity produced in the U.S. which led to policies being adopted that encourage the use of renewable energy. The change in production practices due to policies may have led to changes in the productivity of electric generation plants. Multiple studies have examined the most efficient electric generation plants using the data envelopment analysis (DEA) approach. This study builds on past research to answer three questions: 1) Does the level of aggregation of fuel input variables affect the plant efficiency scores and how does the efficiency of renewable energy input compare to nonrenewable energy inputs; 2) Are policies geared toward directly or indirectly reducing greenhouse gas emissions affecting the production efficiencies of greenhouse gas emitting electric generation plants; and 3) Do renewable energy policies and the use of intermittent energy sources (i.e. wind and solar) affect the productivity growth of electric generation plants. All three analysis, presented in three essays, use U.S. plant level data obtained from the Energy Information Administration to answer these questions. The first two essays use DEA to determine the pure technical, overall technical, and scale efficiencies of electric generation plants. The third essay uses DEA within the Malmquist index to assess the change in productivity over time. Results indicate that the level of aggregation does matter particularly for scale efficiency. This implies that valuable information is likely lost when fuel inputs are aggregated together. Policies directly focused on reducing greenhouse gas emissions may improve the production efficiencies of

  5. DWPF CATALYTIC HYDROGEN GENERATION PROGRAM - REVIEW OF CURRENT STATUS

    SciTech Connect

    Koopman, D.

    2009-07-10

    Significant progress has been made in the past two years in improving the understanding of acid consumption and catalytic hydrogen generation during the Defense Waste Processing Facility (DWPF) processing of waste sludges in the Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator (SME). This report reviews issues listed in prior internal reviews, describes progress with respect to the recommendations made by the December 2006 external review panel, and presents a summary of the current understanding of catalytic hydrogen generation in the DWPF Chemical Process Cell (CPC). Noble metals, such as Pd, Rh, and Ru, are historically known catalysts for the conversion of formic acid into hydrogen and carbon dioxide. Rh, Ru, and Pd are present in the DWPF SRAT feed as by-products of thermal neutron fission of {sup 235}U in the original waste. Rhodium appears to become most active for hydrogen as the nitrite ion concentration becomes low (within a factor of ten of the Rh concentration). Prior to hydrogen generation, Rh is definitely active for nitrite destruction to N{sub 2}O and potentially active for nitrite to NO formation. These reactions are all consistent with the presence of a nitro-Rh complex catalyst, although definite proof for the existence of this complex during Savannah River Site (SRS) waste processing does not exist. Ruthenium does not appear to become active for hydrogen generation until nitrite destruction is nearly complete (perhaps less nitrite than Ru in the system). Catalytic activity of Ru during nitrite destruction is significantly lower than that of either Rh or Pd. Ru appears to start activating as Rh is deactivating from its maximum catalytic activity for hydrogen generation. The slow activation of the Ru, as inferred from the slow rate of increase in hydrogen generation that occurs after initiation, may imply that some species (perhaps Ru itself) has some bound nitrite on it. Ru, rather than Rh, is primarily responsible for the

  6. Weyl current, scale-invariant inflation, and Planck scale generation

    NASA Astrophysics Data System (ADS)

    Ferreira, Pedro G.; Hill, Christopher T.; Ross, Graham G.

    2017-02-01

    Scalar fields, ϕi, can be coupled nonminimally to curvature and satisfy the general criteria: (i) the theory has no mass input parameters, including MP=0 ; (ii) the ϕi have arbitrary values and gradients, but undergo a general expansion and relaxation to constant values that satisfy a nontrivial constraint, K (ϕi)=constant; (iii) this constraint breaks scale symmetry spontaneously, and the Planck mass is dynamically generated; (iv) there can be adequate inflation associated with slow roll in a scale-invariant potential subject to the constraint; (v) the final vacuum can have a small to vanishing cosmological constant; (vi) large hierarchies in vacuum expectation values can naturally form; (vii) there is a harmless dilaton which naturally eludes the usual constraints on massless scalars. These models are governed by a global Weyl scale symmetry and its conserved current, Kμ. At the quantum level the Weyl scale symmetry can be maintained by an invariant specification of renormalized quantities.

  7. Improved eddy-current inspection for steam generator tubing

    SciTech Connect

    Dodd, C.V.; Pate, J.R.; Allen, J.D. Jr.; Allen , Knoxville, TN )

    1989-01-01

    Computer programs have been written to allow the analysis of different types of eddy-current probes and their performance under different steam generator test conditions. The probe types include the differential bobbin probe, the absolute bobbin probe, the pancake probe and the reflection probe. The generator test conditions include tube supports, copper deposits, magnetite deposits, denting, wastage, pitting, cracking and IGA. These studies are based mostly on computed values, with the limited number of test specimens available used to verify the computed results. The instrument readings were computed for a complete matrix of the different test conditions, and then the test conditions determined as a function of the readings by a least-squares technique. A comparison was made of the errors in fit and instrument drift for the different probe types. The computations of the change in instrument reading due to the defects have led to an inversion'' technique in which the defect properties can be computed from the instrument readings. This has been done both experimentally and analytically for each of these probe types. 3 refs., 13 figs., 1 tab.

  8. Steam generator degradation: Current mitigation strategies for controlling corrosion

    SciTech Connect

    Millett, P.

    1997-02-01

    Steam Generator degradation has caused substantial losses of power generation, resulted in large repair and maintenance costs, and contributed to significant personnel radiation exposures in Pressurized Water Reactors (PWRs) operating throughout the world. EPRI has just published the revised Steam Generator Reference Book, which reviews all of the major forms of SG degradation. This paper discusses the types of SG degradation that have been experienced with emphasis on the mitigation strategies that have been developed and implemented in the field. SG degradation is presented from a world wide perspective as all countries operating PWRs have been effected to one degree or another. The paper is written from a US. perspective where the utility industry is currently undergoing tremendous change as a result of deregulation of the electricity marketplace. Competitive pressures are causing utilities to strive to reduce Operations and Maintenance (O&M) and capital costs. SG corrosion is a major contributor to the O&M costs of PWR plants, and therefore US utilities are evaluating and implementing the most cost effective solutions to their corrosion problems. Mitigation strategies developed over the past few years reflect a trend towards plant specific solutions to SG corrosion problems. Since SG degradation is in most cases an economic problem and not a safety problem, utilities can focus their mitigation strategies on their unique financial situation. Accordingly, the focus of R&D has shifted from the development of more expensive, prescriptive solutions (e.g. reduced impurity limits) to corrosion problems to providing the utilities with a number of cost effective mitigation options (e.g. molar ratio control, boric acid treatment).

  9. Nanominerals, fullerene aggregates, and hazardous elements in coal and coal combustion-generated aerosols: An environmental and toxicological assessment.

    PubMed

    Saikia, Jyotilima; Narzary, Bardwi; Roy, Sonali; Bordoloi, Manobjyoti; Saikia, Prasenjit; Saikia, Binoy K

    2016-12-01

    Studies on coal-derived nanoparticles as well as nano-minerals are important in the context of the human health and the environment. The coal combustion-generated aerosols also affect human health and environmental quality aspects in any coal-fired station. In this study, the feed coals and their combustion-generated aerosols from coal-fired boilers of two tea industry facilities were investigated for the presence of nanoparticles/nano minerals, fullerene aggregates, and potentially hazardous elements (PHEs). The samples were characterized by using X-ray diffraction (XRD), Time-of-flight secondary ion mass spectroscopy (TOF-SIMS), High resolution-transmission electron microscopy/energy dispersive spectroscopy (HR-TEM/EDS) and Ultra Violet-visible spectroscopy (UV-Vis) to know their extent of environmental risks to the human health when present in coals and aerosols. The feed coals contain mainly clay minerals, whilst glass fragments, spinel, quartz, and other minerals occur in lesser quantities. The PM samples contain potentially hazardous elements (PHEs) like As, Pb, Cd and Hg. Enrichment factor of the trace elements in particulate matters (PMs) was calculated to determine their sources. The aerosol samples were also found to contain nanomaterials and ultrafine particles. The fullerene aggregates along with potentially hazardous elements were also detected in the aerosol samples. The cytotoxicity studies on the coal combustion-generated PM samples show their potential risk to the human health. This detailed investigation on the inter-relationship between the feed coals and their aerosol chemistry will be useful for understanding the extent of environmental hazards and related human health risk.

  10. Current status of the UCSF second-generation PACS

    NASA Astrophysics Data System (ADS)

    Huang, H. K.; Arenson, Ronald L.; Wong, Albert W. K.; Bazzill, Todd M.; Lou, Shyhliang A.; Andriole, Katherine P.; Wang, Jun; Zhang, Jianguo; Wong, Stephen T. C.

    1996-05-01

    This paper describes the current status of the second generation PACS at UCSF commenced in October 1992. The UCSF PACS is designed in-house as a hospital-integrated PACS based on an open architecture concept using industrial standards including UNIX operating system, C programming language, X-Window user interface, TCP/IP communication protocol, DICOM 3.0 image standard and HL7 health data format. Other manufacturer's PACS components which conform with these standards can be easily integrated into the system. Relevant data from HIS and RIS is automatically incorporated into the PACS using HL7 data format and TCP/IP communication protocol. The UCSF system also takes advantage of state-of-the-art communication, storage, and software technologies in ATM, multiple storage media, automatic programming, multilevel processes for a better cost-performance system. The primary PACS network is the 155 Mbits/sec OC3 ATM with the Ethernet as the back-up. The UCSF PACS also connects Mt. Zion Hospital and San Francisco VA Medical Center in the San Francisco Bay area via an ATM wide area network with a T1 line as the back-up. Currently, five MR and five CT scanners from multiple sites, two computed radiography systems, two film digitizers, one US PACS module, the hospital HIS and the department RIS have been connected to the PACS network. The image data is managed by a mirrored database (Sybase). The PACS controller, with its 1.3 terabyte optical disk library, acquires 2.5 gigabytes digital data daily. Four 2K, five, 1,600-line multiple monitor display workstations are on line in neuroradiology, pediatric radiology and intensive care units for clinical use. In addition, the PACS supports over 100 Macintosh users in the department and selected hospital sites for both images and textual retrieval through a client/server mechanism. We are also developing a computation and visualization node in the PACS network for advancing radiology research.

  11. Structural Characterization of IgG1 mAb Aggregates and Particles Generated under Various Stress Conditions

    PubMed Central

    Telikepalli, Srivalli N.; Kumru, Ozan S.; Kalonia, Cavan; Esfandiary, Reza; Joshi, Sangeeta B.; Middaugh, C. Russell; Volkin, David B.

    2014-01-01

    IgG1 mAb solutions were prepared with and without sodium chloride and subjected to different environmental stresses. Formation of aggregates and particles of varying size was monitored by a combination of size exclusion chromatography (SEC), Nanosight Tracking Analysis (NTA), Micro-flow Imaging (MFI), turbidity, and visual assessments. Stirring and heating induced the highest concentration of particles. In general, the presence of NaCl enhanced this effect. The morphology of the particles formed from mAb samples exposed to different stresses was analyzed from TEM and MFI images. Shaking samples without NaCl generated the most fibrillar particles, while stirring created largely spherical particles. The composition of the particles was evaluated for covalent cross-linking by SDS-PAGE, overall secondary structure by FTIR microscopy, and surface apolarity by extrinsic fluorescence spectroscopy. Freeze-thaw and shaking led to particles containing protein with native-like secondary structure. Heating and stirring produced IgG1 containing aggregates and particles with some non-native disulfide crosslinks, varying levels of intermolecular beta sheet content, and increased surface hydrophobicity. These results highlight the importance of evaluating protein particle morphology and composition, in addition to particle number and size distributions, to better understand the effect of solution conditions and environmental stresses on the formation of protein particles in mAb solutions. PMID:24452866

  12. The Aggregate Description of Semi-Arid Vegetation with Precipitation-Generated Soil Moisture Heterogeneity

    NASA Technical Reports Server (NTRS)

    White, Cary B.; Houser, Paul R.; Arain, Altaf M.; Yang, Zong-Liang; Syed, Kamran; Shuttleworth, W. James

    1997-01-01

    Meteorological measurements in the Walnut Gulch catchment in Arizona were used to synthesize a distributed, hourly-average time series of data across a 26.9 by 12.5 km area with a grid resolution of 480 m for a continuous 18-month period which included two seasons of monsoonal rainfall. Coupled surface-atmosphere model runs established the acceptability (for modelling purposes) of assuming uniformity in all meteorological variables other than rainfall. Rainfall was interpolated onto the grid from an array of 82 recording rain gauges. These meteorological data were used as forcing variables for an equivalent array of stand-alone Biosphere-Atmosphere Transfer Scheme (BATS) models to describe the evolution of soil moisture and surface energy fluxes in response to the prevalent, heterogeneous pattern of convective precipitation. The calculated area-average behaviour was compared with that given by a single aggregate BATS simulation forced with area-average meteorological data. Heterogeneous rainfall gives rise to significant but partly compensating differences in the transpiration and the intercepted rainfall components of total evaporation during rain storms. However, the calculated area-average surface energy fluxes given by the two simulations in rain-free conditions with strong heterogeneity in soil moisture were always close to identical, a result which is independent of whether default or site-specific vegetation and soil parameters were used. Because the spatial variability in soil moisture throughout the catchment has the same order of magnitude as the amount of rain failing in a typical convective storm (commonly 10% of the vegetation's root zone saturation) in a semi-arid environment, non-linearitv in the relationship between transpiration and the soil moisture available to the vegetation has limited influence on area-average surface fluxes.

  13. Ionic channel function in action potential generation: current perspective.

    PubMed

    Baranauskas, Gytis

    2007-04-01

    Over 50 years ago, Hodgkin and Huxley laid down the foundations of our current understanding of ionic channels. An impressive progress has been made during the following years that culminated in the revelation of the details of potassium channel structure. Nevertheless, even today, we cannot separate well currents recorded in central mammalian neurons. Many modern concepts about the function of sodium and potassium currents are based on experiments performed in nonmammalian cells. The recent recognition of the fast delayed rectifier current indicates that we need to reevaluate the biophysical role of sodium and potassium currents. This review will consider high quality voltage clamp data obtained from the soma of central mammalian neurons in the view of our current knowledge about proteins forming ionic channels. Fast sodium currents and three types of outward potassium currents, the delayed rectifier, the subthreshold A-type, and the D-type potassium currents, are discussed here. An updated current classification with biophysical role of each current subtype is provided. This review shows that details of kinetics of both sodium and outward potassium currents differ significantly from the classical descriptions and these differences may be of functional significance.

  14. Apparatus for electrode current control in linear MHD generators

    DOEpatents

    Demirjian, Ara M.; Solbes, Albert

    1984-01-01

    Apparatus for controlling a plurality of opposing, electrode, direct-currents at pre-set locations across a channel that comprises a converter for converting each electrode current into first and second periodic control signals which are 180.degree. out of phase with respect to each other and which have equal magnitudes corresponding to the magnitude of the associated electrode current; and couplers for magnetically coupling individual ones of the first control signals and for magnetically coupling individual ones of the second signals such that the corresponding electrode currents are equalized or rendered proportional by balancing the same in the same or constant ratios in accordance with the locations of the electrode currents.

  15. Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reports.

    PubMed

    Henry, Theodore B; Petersen, Elijah J; Compton, Robert N

    2011-08-01

    This review aims to clarify inconsistencies in previous reports regarding the potential for aqueous aggregates of fullerenes (nC60) to generate reactive oxygen species (ROS) and cause toxicity in fish. Methods for evaluation of ROS production and toxicity of aqueous nC60 have evolved over time and limitations in initial studies have led to unintentional erroneous reports of nC60 ROS generation and toxicity. Some of these reports continue to lead to misconceptions of the environmental effects of C60. Critical review of the evidence (2007-2011) indicates that aqueous nC60 have minimal potential to produce ROS and that oxidative stress in fish is not induced by environmentally relevant exposure to nC60. Future studies should acknowledge that current evidence indicates low toxicity of nC60 and refrain from citing articles that attribute toxicity in fish to nC60 based on methods shown to be compromised by experimental artifacts. Despite low toxicity of nC60 in fish, an emerging environmental issue is that nC60 can affect environmental fate, transport, and bioavailability of co-contaminants in aquatic environments in a similar manner to that observed for other anthropogenic particulates (e.g., microplastics).

  16. Signal generator converts direct current to multiphase supplies

    NASA Technical Reports Server (NTRS)

    Baude, J.

    1967-01-01

    Multiphase wave generator uses multivibrators in a feedback control mode that produces output signal pairs that are impressed on the primary windings of inverter transformers sequentially with a 120 degree phase shift from each other.

  17. Access to Government-Generated Information: Current Issues and Implications.

    ERIC Educational Resources Information Center

    Williamson, Linda E.

    1987-01-01

    Reviews both historical and current policies for access to government information, and discusses such current trends in government information as paperwork reduction, commercialization, privatization, and electronic publishing. The possible impact of these trends on the library's ability to provide access to information is briefly considered. (CLB)

  18. Generation of magnetic skyrmion bubbles by inhomogeneous spin Hall currents

    DOE PAGES

    Heinonen, Olle; Jiang, Wanjun; Somaily, Hamoud; ...

    2016-03-07

    Recent experiments have shown that magnetic skyrmion bubbles can be generated and injected at room temperature in thin films. In this study, we demonstrate, using micromagnetic modeling, that such skyrmions can be generated by an inhomogeneous spin Hall torque in the presence of Dzyaloshinskii-Moriya interactions (DMIs). In the experimental Ta-Co20Fe60B20 thin films, the DMI is rather small; nevertheless, the skyrmion bubbles are stable, or at least metastable on observational time scales.

  19. Generation of magnetic skyrmion bubbles by inhomogeneous spin Hall currents

    SciTech Connect

    Heinonen, Olle; Jiang, Wanjun; Somaily, Hamoud; te Velthuis, Suzanne G. E.; Hoffmann, Axel

    2016-03-07

    Recent experiments have shown that magnetic skyrmion bubbles can be generated and injected at room temperature in thin films. In this study, we demonstrate, using micromagnetic modeling, that such skyrmions can be generated by an inhomogeneous spin Hall torque in the presence of Dzyaloshinskii-Moriya interactions (DMIs). In the experimental Ta-Co20Fe60B20 thin films, the DMI is rather small; nevertheless, the skyrmion bubbles are stable, or at least metastable on observational time scales.

  20. Displacement Current and the Generation of Parallel Electric Fields

    SciTech Connect

    Song Yan; Lysak, Robert L.

    2006-04-14

    We show for the first time the dynamical relationship between the generation of magnetic field-aligned electric field (E{sub parallel}) and the temporal changes and spatial gradients of magnetic and velocity shears, and the plasma density in Earth's magnetosphere. We predict that the signatures of reconnection and auroral particle acceleration should have a correlation with low plasma density, and a localized voltage drop (V{sub parallel}) should often be associated with a localized magnetic stress concentration. Previous interpretations of the E{sub parallel} generation are mostly based on the generalized Ohm's law, causing serious confusion in understanding the nature of reconnection and auroral acceleration.

  1. Current and Next Generation Portable Screening Devices for Diabetic Retinopathy

    PubMed Central

    Micheletti, J. Morgan; Hendrick, Andrew M.; Khan, Farah N.; Ziemer, David C.; Pasquel, Francisco J.

    2016-01-01

    Diabetic retinopathy (DR) is the leading cause of legal blindness in the United States, and with the growing epidemic of diabetes, a global increase in the incidence of DR is inevitable, so it is of utmost importance to identify the most cost-effective tools for DR screening. Emerging technology may provide advancements to offset the burden of care, simplify the process, and provide financially responsible methods to safely and effectively optimize care for patients with diabetes mellitus (DM). We review here currently available technology, both in production and under development, for DR screening. Preliminary results of smartphone-based devices, “all-in-one” devices, and alternative technologies are encouraging, but are largely pending verification of utility when used by nonophthalmic personnel. Further research comparing these devices to current nonportable telemedicine strategies and clinical fundus examination is necessary to validate these techniques and to potentially overcome the poor compliance around the globe of current strategies for DR screening. PMID:26888973

  2. 270 Volt Direct Current Generating System Design, Development and Test

    DTIC Science & Technology

    1991-08-01

    Figure 3-1 Rotor Lamination 9 Table 3-1 Electrical Performance Characteristics 10 Table 3-2 Bore Stresses - PSi 17 I Table 3-3 Materials and...bridge, interphase transformer and filter capacitors. The main generator stator and rotor consist of laminated structures assembled from cobalt-iron alloy...instant the voltage difference between the two bridges and thereby ensures 120 degree conduction and balanced load sharing by each of the 12 output

  3. Survey of Current and Next Generation Space Power Technologies

    DTIC Science & Technology

    2006-06-26

    porous carbon and sulfur dioxide (or thionyl chloride ), electrolyte of acetronitrile and lithium bromide salt, the lithium sulfur dioxide chemistry...TRL 6); recent laboratory developments have yielded energy densities of 600 Wh/kg22. Lithium -Air- Lithium -air batteries consist of lithium anodes...generation, battery types are discussed below and a comparative table of traditional non- lithium , terrestrial battery types are presented in Table 11

  4. Electronic constant current and current pulse signal generator for nuclear instrumentation testing

    DOEpatents

    Brown, Roger A.

    1994-01-01

    Circuitry for testing the ability of an intermediate range nuclear instrut to detect and measure a constant current and a periodic current pulse. The invention simulates the resistance and capacitance of the signal connection of a nuclear instrument ion chamber detector and interconnecting cable. An LED flasher/oscillator illuminates an LED at a periodic rate established by a timing capacitor and circuitry internal to the flasher/oscillator. When the LED is on, a periodic current pulse is applied to the instrument. When the LED is off, a constant current is applied. An inductor opposes battery current flow when the LED is on.

  5. Electronic constant current and current pulse signal generator for nuclear instrumentation testing

    DOEpatents

    Brown, R.A.

    1994-04-19

    Circuitry is described for testing the ability of an intermediate range nuclear instrument to detect and measure a constant current and a periodic current pulse. The invention simulates the resistance and capacitance of the signal connection of a nuclear instrument ion chamber detector and interconnecting cable. An LED flasher/oscillator illuminates an LED at a periodic rate established by a timing capacitor and circuitry internal to the flasher/oscillator. When the LED is on, a periodic current pulse is applied to the instrument. When the LED is off, a constant current is applied. An inductor opposes battery current flow when the LED is on. 1 figures.

  6. Staged Inductive Pulse Generator with Capacitive Current Source.

    DTIC Science & Technology

    1986-10-24

    depends on the performance of the fuse opening switch and the vacuum flashover output switch. Sections III and IV briefly discuss the development of these...It was assumed that the vacuum flashover switch closed when 20 kV was across it, compared with the measured value of 25 kV. C. Late-Time Voltage ...up to 25 kV/cm when the voltage pulse generated by the second fuse is applied 1-2 us after the first fuse explodes. IV. VACUUM FLASHOVER SWITCH A

  7. Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells*

    PubMed Central

    Moree, Ben; Yin, Guowei; Lázaro, Diana F.; Munari, Francesca; Strohäker, Timo; Giller, Karin; Becker, Stefan; Outeiro, Tiago F.; Zweckstetter, Markus; Salafsky, Joshua

    2015-01-01

    Proteins are structurally dynamic molecules that perform specialized functions through unique conformational changes accessible in physiological environments. An ability to specifically and selectively control protein function via conformational modulation is an important goal for development of novel therapeutics and studies of protein mechanism in biological networks and disease. Here we applied a second-harmonic generation-based technique for studying protein conformation in solution and in real time to the intrinsically disordered, Parkinson disease related protein α-synuclein. From a fragment library, we identified small molecule modulators that bind to monomeric α-synuclein in vitro and significantly reduce α-synuclein aggregation in a neuronal cell culture model. Our results indicate that the conformation of α-synuclein is linked to the aggregation of protein in cells. They also provide support for a therapeutic strategy of targeting specific conformations of the protein to suppress or control its aggregation. PMID:26396193

  8. Current next generation sequencing technology may not meet forensic standards.

    PubMed

    Bandelt, Hans-Jürgen; Salas, Antonio

    2012-01-01

    In a Nature paper of 2010, the concern was raised that intra-individual mtDNA variation may be more pronounced than previously believed, in that heteroplasmies are common and vary markedly from tissue to tissue. This claim taken at face value would have considerable impact on forensic casework. It turns out however that the employed technology detected the germ-line variation relative to the reference sequence only incompletely: on average at least five mutations were missed per sample, as an in silico reassessment of the data reveals. Before one can really set out to access to entire mtDNA genome data with relative ease for forensic purposes, one needs careful calibration studies under strict forensic conditions-or might have to wait for another generation.

  9. Ocean currents generate large footprints in marine palaeoclimate proxies.

    PubMed

    van Sebille, Erik; Scussolini, Paolo; Durgadoo, Jonathan V; Peeters, Frank J C; Biastoch, Arne; Weijer, Wilbert; Turney, Chris; Paris, Claire B; Zahn, Rainer

    2015-03-04

    Fossils of marine microorganisms such as planktic foraminifera are among the cornerstones of palaeoclimatological studies. It is often assumed that the proxies derived from their shells represent ocean conditions above the location where they were deposited. Planktic foraminifera, however, are carried by ocean currents and, depending on the life traits of the species, potentially incorporate distant ocean conditions. Here we use high-resolution ocean models to assess the footprint of planktic foraminifera and validate our method with proxy analyses from two locations. Results show that foraminifera, and thus recorded palaeoclimatic conditions, may originate from areas up to several thousands of kilometres away, reflecting an ocean state significantly different from the core site. In the eastern equatorial regions and the western boundary current extensions, the offset may reach 1.5 °C for species living for a month and 3.0 °C for longer-living species. Oceanic transport hence appears to be a crucial aspect in the interpretation of proxy signals.

  10. Next-generation dengue vaccines: novel strategies currently under development.

    PubMed

    Durbin, Anna P; Whitehead, Stephen S

    2011-10-01

    Dengue has become the most important arboviral infection worldwide with more than 30 million cases of dengue fever estimated to occur each year. The need for a dengue vaccine is great and several live attenuated dengue candidate vaccines are proceeding through clinical evaluation. The need to induce a balanced immune response against all four DENV serotypes with a single vaccine has been a challenge for dengue vaccine developers. A live attenuated DENV chimeric vaccine produced by Sanofi Pasteur has recently entered Phase III evaluation in numerous dengue-endemic regions of the world. Viral interference between serotypes contained in live vaccines has required up to three doses of the vaccine be given over a 12-month period of time. For this reason, novel DENV candidate vaccines are being developed with the goal of achieving a protective immune response with an immunization schedule that can be given over the course of a few months. These next-generation candidates include DNA vaccines, recombinant adenovirus vectored vaccines, alphavirus replicons, and sub-unit protein vaccines. Several of these novel candidates will be discussed.

  11. Study of the generation and suppression of runaway currents in provoked disruptions in J-TEXT

    NASA Astrophysics Data System (ADS)

    Chen, Z. Y.; Chen, Z. P.; Zhang, Y.; Jin, W.; Fang, D.; Ba, W. G.; Wang, Z. J.; Zhang, M.; Yang, Z. J.; Ding, Y. H.; Zhuang, G.; J-TEXT Team

    2012-05-01

    Runaway currents following disruptions have an important effect on the first wall for the next generation tokamak. The behaviors of runaway currents following intentional provoked disruptions have been investigated in the J-TEXT tokamak. It is found that the runaway current generation following provoked disruptions depends on both the toroidal magnetic field and the plasma current. The conversion efficiency of pre-disruptive plasma currents into runaway currents is in the ranges of 30% to 60% in J-TEXT. The runaway currents can be avoided by the intensive gas puffing of H2 due to the low multiplication factor in J-TEXT.

  12. The drive to strive: goal generation based on current needs

    PubMed Central

    Murray, Elisabeth A.; Rudebeck, Peter H.

    2013-01-01

    Hungry animals are influenced by a multitude of different factors when foraging for sustenance. Much of the work on animal foraging has focused on factors relating to the amount of time and energy animals expend searching for and harvesting foods. Models that emphasize such factors have been invaluable in determining when it is beneficial for an animal to search for pastures new. When foraging, however, animals also have to determine how to direct their search. For what food should they forage? There is no point searching for more of a particular food when you are sated from eating it. Here we review work in macaques and humans that has sought to reveal the neural circuits critical for determining the subjective value of different foods and associated objects in our environment and tracking this value over time. There is mounting evidence that a network composed of the orbitofrontal cortex (OFC), amygdala, and medial thalamus is critical for linking objects in the environment with food value and adjusting those valuations in real time based on current biological needs. Studies using temporary inactivation methods have revealed that the amygdala and OFC play distinct yet complementary roles in this valuation process. Such a network for determining the subjective value of different foods and, by extension, associated objects, must interact with systems that determine where and for how long to forage. Only by efficiently incorporating these two factors into their decisions will animals be able to achieve maximal fitness. PMID:23818876

  13. Return Current Electron Beams and Their Generation of "Raman" Scattering

    NASA Astrophysics Data System (ADS)

    Simon, A.

    1998-11-01

    For some years, we(A. Simon and R. W. Short, Phys. Rev. Lett. 53), 1912 (1984). have proposed that the only reasonable explanation for many of the observations of "Raman" scattering is the presence of an electron beam in the plasma. (The beam creates a bump-on-tail instability.) Two major objections to this picture have been observation of Raman when no n_c/4 surface was present, with no likely source for the electron beam, and the necessity for the initially outward directed beam to bounce once to create the proper waves. Now new observations on LLE's OMEGA(R. Petrasso et al), this conference. and at LULI(C. Labaune et al)., Phys. Plasma 5, 234 (1998). have suggested a new origin for the electron beam. This new scenario answers the previous objections, maintains electron beams as the explanation of the older experiments, and may clear up puzzling observations that have remained unexplained. The new scenario is based on two assumptions: (1) High positive potentials develop in target plasmas during their creation. (2) A high-intensity laser beam initiates spark discharges from nearby surfaces to the target plasma. The resulting return current of electrons should be much more delta-like, is initially inwardly directed, and no longer requires the continued presence of a n_c/4 surface. Scattering of the interaction beam from the BOT waves yields the observed Raman signal. Experimental observations that support this picture will be cited. ``Pulsation'' of the scattering and broadband ``flashes'' are a natural part of this scenario. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC03-92SF19460.

  14. Shift in aggregation, ROS generation, antioxidative defense, lysozyme and acetylcholinesterase activities in the cells of an Indian freshwater sponge exposed to washing soda (sodium carbonate).

    PubMed

    Mukherjee, Soumalya; Ray, Mitali; Ray, Sajal

    2016-09-01

    Washing soda, chemically identified as anhydrous sodium carbonate, is a popular cleaning agent among the rural and urban populations of India which often contaminates the freshwater ponds and lakes, the natural habitat of sponge Eunapius carteri. Present investigation deals with estimation of cellular aggregation, generation of ROS and activities of antioxidant enzymes, lysozyme and acetylcholinesterase in the cells of E. carteri under the environmentally realistic concentrations of washing soda. Prolonged treatment of washing soda inhibited the degree of cellular aggregation. Experimental exposure of 8 and 16mg/l of sodium carbonate for 48h elevated the physiological level of reactive oxygen species (ROS) generation in the agranulocytes, semigranulocytes and granulocytes of E. carteri, whereas, treatment of 192h inhibited the ROS generation in three cellular morphotypes. Activities of superoxide dismutase, catalase and glutathione-S-transferase were recorded to be inhibited under prolonged exposure of washing soda. Washing soda mediated inhibition of ROS generation and depletion in the activities of antioxidant enzymes were indicative to an undesirable shift in cytotoxic status and antioxidative defense in E. carteri. Inhibition in the activity of lysozyme under the treatment of sodium carbonate was suggestive to a severe impairment of the innate immunological efficiency of E. carteri distributed in the washing soda contaminated habitat. Washing soda mediated inhibition in the activity of acetylcholinesterase indicated its neurotoxicity in E. carteri. Washing soda, a reported environmental contaminant, affected adversely the immunophysiological status of E. carteri with reference to cellular aggregation, oxidative stress, antioxidative defense, lysozyme and acetylcholinesterase activity.

  15. Generation of coronal electric currents due to convective motions on the photosphere

    NASA Technical Reports Server (NTRS)

    Sakurai, T.; Levine, R. H.

    1981-01-01

    Generation of electric currents in a magnetized plasma overlying a dense convective layer is studied, assuming that the magnetic field perturbation is small and satisfies the force-free equation. Currents are produced by rotational motions on the boundary in the case of a uniform equilibrium field. In a simple two-dimensional bipolar configuration, however, both irrotational and incompressible motions give rise to currents, and the current density has a peak at the magnetic neutral line. Scaling laws for the current density as well as for the stored magnetic energy are derived, and the possibility of heating the solar corona through the dissipation of coronal currents generated in this way is discussed.

  16. Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons

    PubMed Central

    Liu, Hao; Li, Wenjin; Ahmad, Muzamil; Rose, Marie E.; Miller, Tricia M.; Yu, Mei; Chen, Jie; Pascoe, Jordan L.; Poloyac, Samuel M.; Hickey, Robert W.; Graham, Steven H.

    2013-01-01

    The cyclopentenone prostaglandin (CyPG) J2 series, including prostaglandin J2 (PGJ2), Δ12-PGJ2 and 15-deoxy-Δ12, 14 -prostaglandin J2 (15d-PGJ2), are active metabolites of PGD2, exerting multiple effects on neuronal function. However, the physiologic relevance of these effects remains uncertain as brain concentrations of CyPGs have not been precisely determined. In this study, we found that free PGD2 and the J2 series CyPGs (PGJ2, Δ12-PGJ2 and 15d-PGJ2) were increased in post-ischemic rat brain as detected by UPLC-MS/MS with 15d-PGJ2 being the most abundant CyPG. These increases were attenuated by pre-treating with the cyclooxygenase inhibitor piroxicam. Next, effects of chronic exposure to 15d-PGJ2 were examined by treating primary neurons with 15d-PGJ2, CAY10410 (a 15d-PGJ2 analog lacking the cyclopentenone ring structure), or vehicle for 24 h to 96 h. Because we found that the concentration of free 15d-PGJ2 decreased rapidly in cell culture medium, freshly prepared medium containing 15d-PGJ2, CAY10410 or vehicle was changed twice daily to maintain steady extracellular concentrations. Incubation with 2.5 μM 15d-PGJ2, but not CAY10410, increased neuronal cell death without induction of caspase-3 or PARP cleavage, consistent with a primarily necrotic mechanism for 15d-PGJ2-induced cell death which was further supported by TUNEL assay results. Ubiquitinated protein accumulation and aggregation was observed after 96 h 15d-PGJ2 incubation, accompanied by compromised 20S proteasome activity. Unlike another proteasome inhibitor, MG132, 15d-PGJ2 treatment did not activate autophagy or induce aggresome formation. Therefore, the cumulative cytotoxic effects of increased generation of CyPGs after stroke may contribute to delayed post-ischemic neuronal injury. PMID:23355003

  17. Family Aggregation and Risk Factors in Phobic Disorders over Three-Generations in a Nation-Wide Study

    PubMed Central

    Steinhausen, Hans-Christoph; Jakobsen, Helle; Meyer, Andrea; Jørgensen, Povl Munk; Lieb, Roselind

    2016-01-01

    Objective This nation-wide register-based study investigated how often phobic disorders (PHO) and co-morbid disorders occur in affected families compared to control families. Furthermore, the study addressed the impact of sex, year of birth, and degree of urbanization in terms of risk factors. Method A total of N = 746 child and adolescent psychiatric participants born between 1969 and 1986 and registered in the Danish Psychiatric Central Research Register (DPCRR) with a diagnosis of a mental disorder before the age of 18, and developed PHO at some point during their life-time until a maximum age of 40 years were included. In addition, N = 2229 controls without any diagnosis of mental disorders before age 18 and that were matched for age, sex, and residential region were included. Diagnoses of mental disorders were also obtained from the first- degree relatives as a part of the Danish Three Generation Study (3GS). A family load component was obtained by using various mixed regression models. Results PHO occurred significantly more often in case than in control families, in particular, in mothers and siblings. Substance use disorders (SUD), Depressive disorders (DEP), anxiety disorders (ANX) and personality disorders (PERS) in the family were significantly associated with specific phobia in the case-probands. After controlling for various mental disorders comorbid to PHO it was found that some of the family transmission could be caused by various other mental disorders in family members rather than the PHO itself. Female sex and more recent year of birth were further risk factors while region of residence was not related to the manifestation of PHO. Case-relatives did not develop PHO earlier than control relatives. After adjusting for various additional explanatory variables, the family load explained only 0.0013% of the variance in the manifestation of PHO in the case-probands Discussion These findings, based on a very large and representative dataset, provide

  18. Effects of Humic Acid and Sunlight on the Generation and Aggregation State of Aqu/C60 Nanoparticles

    EPA Science Inventory

    Aqueous suspensions of nanoscale C60 aggregates (aqu/C60) were produced by stirring in water with Suwanee River Humic Acid (humic acid) and water from Call’s Creek, a small stream near Athens, GA. Time course experiments were conducted to determine the effects of sunlight and sol...

  19. Current-generating ‘double layer shoe’ with a porous sole

    NASA Astrophysics Data System (ADS)

    Kolomeisky, Anatoly B.; Kornyshev, Alexei A.

    2016-11-01

    We present a principle and a simple theory of a novel reverse electroactuator, in which the electrical current is generated by pumping an electrolytic liquid into nonwetting pores of a polarized electrode. The theory establishes the relationship between the variation of external pressure and the electrical current. The effective current density is amplified by the high porosity of the electrode. The suggested principle can be implemented into the design of a shoe which will generate an AC current simply by walking. Estimates of typical parameters and operation regimes of such a device suggest that one can easily generate a peak current density of ~17 mA cm-2. This would produce some 1.7 A from each shoe at 0.65 W average power density, without hampering walking.

  20. Logrithmic current simulator generates electrical currents accurately between 10 to the minus 11 ampere to 10 to the minus 3 ampere

    NASA Technical Reports Server (NTRS)

    Wilson, J.

    1966-01-01

    Current generator accurately simulates electric currents in the range of 10 to the minus 11th power to 0.001 ampere. Compensation networks have been devised to improve the accuracy at the lower current levels.

  1. Observations of wind-generated waves on variable current. [laboratory ocean dynamics for water wave generator research

    NASA Technical Reports Server (NTRS)

    Long, S. R.; Huang, N. E.

    1976-01-01

    Laboratory measurements utilizing a laser probe are made for the slopes of wind waves generated on both positive and negative currents at different values of fetch. The data are then processed electronically to yield an average wave-slope spectrum in frequency space with 128 degrees of freedom. These spectra are used to obtain the growth of the spectral components at various frequency bands for increasing wind and different values of fetch and current. The results indicate that the growth of these components is not monotonic with the frictional wind speed, but rather exhibits an 'overshoot' phenomena at lower values of frictional wind speed, and in addition, displays a significant effect due to current. The peak location and spectral intensity of the spectra also show strong influence by the current condition. This results in the rms surface slope value increasing with negative current and decreasing with positive current. The results agree qualitatively with some theoretical predictions. The potential use of the current-induced effects as a means for remote sensing of ocean current is also briefly discussed.

  2. Methods of high current magnetic field generator for transcranial magnetic stimulation application

    NASA Astrophysics Data System (ADS)

    Bouda, N. R.; Pritchard, J.; Weber, R. J.; Mina, M.

    2015-05-01

    This paper describes the design procedures and underlying concepts of a novel High Current Magnetic Field Generator (HCMFG) with adjustable pulse width for transcranial magnetic stimulation applications. This is achieved by utilizing two different switching devices, the MOSFET and insulated gate bipolar transistor (IGBT). Results indicate that currents as high as ±1200 A can be generated with inputs of +/-20 V. Special attention to tradeoffs between field generators utilizing IGBT circuits (HCMFG1) and MOSFET circuits (HCMFG2) was considered. The theory of operation, design, experimental results, and electronic setup are presented and analyzed.

  3. Methods of high current magnetic field generator for transcranial magnetic stimulation application

    SciTech Connect

    Bouda, N. R. Pritchard, J.; Weber, R. J.; Mina, M.

    2015-05-07

    This paper describes the design procedures and underlying concepts of a novel High Current Magnetic Field Generator (HCMFG) with adjustable pulse width for transcranial magnetic stimulation applications. This is achieved by utilizing two different switching devices, the MOSFET and insulated gate bipolar transistor (IGBT). Results indicate that currents as high as ±1200 A can be generated with inputs of +/−20 V. Special attention to tradeoffs between field generators utilizing IGBT circuits (HCMFG{sub 1}) and MOSFET circuits (HCMFG{sub 2}) was considered. The theory of operation, design, experimental results, and electronic setup are presented and analyzed.

  4. Mechanism of Small Current Generation under Impulse Voltage Applications in Vacuum

    NASA Astrophysics Data System (ADS)

    Aoki, Keita; Yasukawa, Hideaki; Kojima, Hiroki; Homma, Mitsutaka; Shioiri, Tetsu; Okubo, Hitoshi

    Small discharge not to accompany breakdown can occur under high electric field in vacuum, however the mechanism is not well clarified. We have found that the current of small discharge decreases with repeated voltage applications, and leads to electrode conditioning effect of raising withstand voltage. The inception of the current is delayed with the decrease of current, and the inception time and waveform change by gap length. On the other hand, under low vacuum condition, the current increases and reaches saturation with repeated voltage applications. From these discussions, we concluded that the generating process of small current depended on the adsorption and absorption gas of electrodes.

  5. Compensation for Harmonic Currents and Reactive Power in Wind Power Generation System using PWM Inverter

    NASA Astrophysics Data System (ADS)

    Shinohara, Katsuji; Shinhatsubo, Kurato; Iimori, Kenichi; Yamamoto, Kichiro; Saruban, Takamichi; Yamaemori, Takahiro

    In recent year, consciousness of environmental problems is enhancing, and the price of the electric power purchased by an electric power company is established expensive for the power plant utilizing the natural energy. So, the introduction of the wind power generation is promoted in Japan. Generally, squirrel-cage induction machines are widely used as a generator in wind power generation system because of its small size, lightweight and low-cost. However, the induction machines do not have a source of excitation. Thus, it causes the inrush currents and the instantaneous voltage drop when the generator is directly connected to a power grid. To reduce the inrush currents, an AC power regulator is used. Wind power generations are frequently connected to and disconnected from the power grid. However, when the inrush currents are reduced, harmonic currents are caused by phase control of the AC power regulator. And the phase control of AC power regulator cannot control the power factor. Therefore, we propose the use of the AC power regulator to compensate for the harmonic currents and reactive power in the wind power generation system, and demonstrate the validity of its system by simulated and experimental results.

  6. Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

    PubMed Central

    Roodveldt, Cintia; Labrador-Garrido, Adahir; Gonzalez-Rey, Elena; Fernandez-Montesinos, Rafael; Caro, Marta; Lachaud, Christian C.; Waudby, Christopher A.; Delgado, Mario; Dobson, Christopher M.; Pozo, David

    2010-01-01

    Background Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized pathologically by the presence in the brain of intracellular protein inclusions highly enriched in aggregated alpha-synuclein (α-Syn). Although it has been established that progression of the disease is accompanied by sustained activation of microglia, the underlying molecules and factors involved in these immune-triggered mechanisms remain largely unexplored. Lately, accumulating evidence has shown the presence of extracellular α-Syn both in its aggregated and monomeric forms in cerebrospinal fluid and blood plasma. However, the effect of extracellular α-Syn on cellular activation and immune mediators, as well as the impact of familial PD-linked α-Syn mutants on this stimulation, are still largely unknown. Methods and Findings In this work, we have compared the activation profiles of non-aggregated, extracellular wild-type and PD-linked mutant α-Syn variants on primary glial and microglial cell cultures. After stimulation of cells with α-Syn, we measured the release of Th1- and Th2- type cytokines as well as IP-10/CXCL10, RANTES/CCL5, MCP-1/CCL2 and MIP-1α/CCL3 chemokines. Contrary to what had been observed using cell lines or for the case of aggregated α-Syn, we found strong differences in the immune response generated by wild-type α-Syn and the familial PD mutants (A30P, E46K and A53T). Conclusions These findings might contribute to explain the differences in the onset and progression of this highly debilitating disease, which could be of value in the development of rational approaches towards effective control of immune responses that are associated with PD. PMID:21048992

  7. Inhibition of glutamate receptors reduces the homocysteine-induced whole blood platelet aggregation but does not affect superoxide anion generation or platelet membrane fluidization.

    PubMed

    Karolczak, Kamil; Pieniazek, Anna; Watala, Cezary

    2017-01-01

    Homocysteine (Hcy) is an excitotoxic amino acid. It is potentially possible to prevent Hcy-induced toxicity, including haemostatic impairments, by antagonizing glutaminergic receptors. Using impedance aggregometry with arachidonate and collagen as platelet agonists, we tested whether the blockade of platelet NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and kainate receptors with their inhibitors: MK-801 (dizocilpine hydrogen maleate, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine), CNQX (7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile) and UBP-302 (2-{[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin 1(2H)-yl]methyl}benzoic acid) may hamper Hcy-dependent platelet aggregation. All the tested compounds significantly inhibited Hcy-augmented aggregation of blood platelets stimulated either with arachidonate or collagen. Hcy stimulated the generation of superoxide anion in whole blood samples in a concentration-dependent manner; however, this process appeared as independent on ionotropic glutamate receptors, as well as on NADPH oxidase and protein kinase C, and was not apparently associated with the extent of either arachidonate- or collagen-dependent platelet aggregation. Moreover, Hcy acted as a significant fluidizer of surface (more hydrophilic) and inner (more hydrophobic) regions of platelet membrane lipid bilayer, when used at the concentration range from 10 to 50 µmol/l. However, this effect was independent on the Hcy action through glutamate ionotropic receptors, since there was no effects of MK-801, CNQX or UBP-302 on Hcy-mediated membrane fluidization. In conclusion, Hcy-induced changes in whole blood platelet aggregation are mediated through the ionotopic excitotoxic receptors, although the detailed mechanisms underlying such interactions remain to be elucidated.

  8. Generation of pure spin currents via Auger recombination in quantum wells with Rashba splitting

    SciTech Connect

    Afanasiev, A. N. Greshnov, A. A. Greshnov, A. A.

    2015-10-15

    We propose a nonoptical mechanism for generating spin current via Auger recombination in semiconductor quantum wells (QWs) with spin–orbit splitting associated with structural QW asymmetry. It is shown that Auger recombination in narrow-bandgap semiconductors makes it possible to produce spin currents that exceed those that are obtained in the case of intraband as well as interband optical excitation. Analysis shows that the interference term in the expression for the Auger-recombination rate is responsible for the generation of spin currents.

  9. Performance Evaluation of a 22.5/30 KW 270 Volts Direct Current Generator System

    DTIC Science & Technology

    1993-12-01

    AD-A275 106 WL-TR-93-2025 PERFORMANCE EVALUATION OF A 22.5/30 KW 270 VOLTS DIRECT CURRENT GENERATOR SYSTEM John G. Nairus, David A. Criminski Power...the addressee is no longer employed by your organization please notify WL/POOC , WPAFB, OH 45433- 7251 to help us maintain a current mailing list...30 kW 270 Volts Direct Program Element No. Current Generator System 62203F 6. AUTHOR(S) Work Unit No. 31452939 John G. Nairus, David A. Criminski 7

  10. The ups and downs of coral reef fishes: the genetic characteristics of a formerly severely overfished but currently recovering Nassau grouper fish spawning aggregation

    NASA Astrophysics Data System (ADS)

    Bernard, A. M.; Feldheim, K. A.; Nemeth, R.; Kadison, E.; Blondeau, J.; Semmens, B. X.; Shivji, M. S.

    2016-03-01

    The Nassau grouper ( Epinephelus striatus) has sustained large declines across its distribution, including extirpation of many of its fish spawning aggregations (FSAs). Within US Virgin Islands (USVI) waters, Nassau grouper FSAs were overfished until their disappearance in the 1970s and 1980s. In the early 2000s, however, Nassau grouper were found gathering at Grammanik Bank, USVI, a mesophotic coral reef adjacent to one of the extinct aggregation sites, and regulatory protective measures were implemented to protect this fledgling FSA. The population genetic dynamics of this rapid FSA deterioration followed by protection-facilitated, incipient recovery are unknown. We addressed two objectives: (1) we explored which factors (i.e., local vs. external recruitment) might be key in shaping the USVI FSA recovery; and (2) we examined the consequences of severe past overfishing on this FSA's current genetic status. We genotyped individuals (15 microsatellites) from the USVI FSA comprising three successive spawning years (2008-2010), as well as individuals from a much larger, presumably less impacted, Nassau grouper FSA in the Cayman Islands, to assess their comparative population dynamics. No population structure was detected between the USVI and Cayman FSAs ( F ST = -0.0004); however, a temporally waning, genetic bottleneck signal was detected in the USVI FSA. Parentage analysis failed to identify any parent-offspring matches between USVI FSA adults and nearby juveniles, and relatedness analysis showed low levels of genetic relatedness among USVI FSA individuals. Genetic diversity across USVI FSA temporal collections was relatively high, and no marked differences were found between the USVI and Cayman FSAs. These collective results suggest that external recruitment is an important driver of the USVI FSA recovery. Furthermore, despite an apparent genetic bottleneck, the genetic diversity of USVI Nassau grouper has not been severely compromised. Our findings also provide a

  11. Modelling of Current Density Redistribution in Hollow Needle to Plate Electrical Discharge Designed for Ozone Generation

    NASA Astrophysics Data System (ADS)

    Kriha, Vitezslav

    2003-10-01

    Non-thermal plasma of atmospheric pressure electrical discharges in flowing air can be used to generation of ozone. We have been observed two modes of discharge burning in a hollow needle to plane electrodes configuration studied in the ozone generation experiments: A low current diffuse mode is characterized by increasing of the ozone production with the discharge current; a high current filamentary mode is disadvantageous for the ozone generation(the ozone production decreases when the discharge current increases). A possible interpretation of this effect is following: The filamentary mode discharge current density is redistributed and high current densities in filaments cores lead to degradation of the ozone generation. Local fields in the discharge can be modified by charged metallic and/or dielectric components (passive modulators) in the discharge space. An interactive numerical model has been developed for this purpose. This model is based on Ferguson's polynomial objects for both the discharge chamber scene modelling and the discharge fields analyzing. This approach allows intuitive modifications of modulators shapes and positions in 3D scene followed by quantitative comparison of the current density distribution with previous configurations.

  12. Generation of electric fields and currents by neutral flows in weakly ionized plasmas through collisional dynamos

    NASA Astrophysics Data System (ADS)

    Dimant, Y. S.; Oppenheim, M. M.; Fletcher, A. C.

    2016-08-01

    In weakly ionized plasmas neutral flows drag plasma across magnetic field lines generating intense electric fields and currents. An example occurs in the Earth's ionosphere near the geomagnetic equator. Similar processes take place in the Solar chromosphere and magnetohydrodynamic generators. This paper argues that not all convective neutral flows generate electric fields and currents and it introduces the corresponding universal criterion for their formation, ∇×(U ×B )≠∂B /∂t , where U is the neutral flow velocity, B is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ ̂ . For many systems, the displacement current, ∂B /∂t , is negligible making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates E-fields and currents plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law.

  13. Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability

    PubMed Central

    Montgomery, Jenna R.; Meredith, Andrea L.

    2012-01-01

    Large-conductance calcium-activated potassium channels (BK) are potent negative regulators of excitability in neurons and muscle, and increasing BK current is a novel therapeutic strategy for neuro- and cardioprotection, disorders of smooth muscle hyperactivity, and several psychiatric diseases. However, in some neurons, enhanced BK current is linked with seizures and paradoxical increases in excitability, potentially complicating the clinical use of agonists. The mechanisms that switch BK influence from inhibitory to excitatory are not well defined. Here we investigate this dichotomy using a gain-of-function subunit (BKR207Q) to enhance BK currents. Heterologous expression of BKR207Q generated currents that activated at physiologically relevant voltages in lower intracellular Ca2+, activated faster, and deactivated slower than wild-type currents. We then used BKR207Q expression to broadly augment endogenous BK currents in vivo, generating a transgenic mouse from a circadian clock-controlled Period1 gene fragment (Tg-BKR207Q). The specific impact on excitability was assessed in neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus, a cell type where BK currents regulate spontaneous firing under distinct day and night conditions that are defined by different complements of ionic currents. In the SCN, Tg-BKR207Q expression converted the endogenous BK current to fast-activating, while maintaining similar current-voltage properties between day and night. Alteration of BK currents in Tg-BKR207Q SCN neurons increased firing at night but decreased firing during the day, demonstrating that BK currents generate bidirectional effects on neuronal firing under distinct conditions. PMID:23112153

  14. Generation and coherent control of pure spin currents via terahertz pulses

    NASA Astrophysics Data System (ADS)

    Schüler, Michael; Berakdar, Jamal

    2014-04-01

    We inspect the time and spin-dependent, inelastic tunneling in engineered semiconductor-based double quantum well driven by time-structured terahertz pulses. An essential ingredient is an embedded spin-active structure with vibrational modes that scatter the pulse driven carriers. Due to the different time scales of the charge and spin dynamics, the spin-dependent electron-vibron coupling may result in pure net spin current (with negligible charge current). Heating the vibrational site may affect the resulting spin current. Furthermore, by controlling the charge dynamics, the spin dynamics and the generated spin current can be manipulated and switched on and off coherently.

  15. Edge instability in a chiral stripe domain under an electric current and skyrmion generation

    SciTech Connect

    Lin, Shi -Zeng

    2016-07-05

    Motivated by the recent experimental observations on the skyrmion creation by cutting chiral stripe domains under a current drive [Jiang et al., Science 349, 283 (2015)], we study the mechanism of skyrmion generation by simulating the dynamics of stripe domains. Our theory for skyrmion generation is based on the fact that there are two half skyrmions attached to the ends of a stripe domain. These half skyrmions move due to the coupling between the skyrmion topological charge and current. As a consequence, the stripe domain is bent or stretched depending on the direction of motion of the half skyrmions. For a large current, skyrmions are created by chopping the stripe domains via strong bending or stretching. Our theory provides an explanation to the experiments and is supported by the new experiments. Moreover, we predict that skyrmions can also be generated using a Bloch stripe domain under a spin transfer torque which can be realized in B20 compounds.

  16. Evaluation and field validation of Eddy-Current array probes for steam generator tube inspection

    SciTech Connect

    Dodd, C.V.; Pate, J.R.

    1996-07-01

    The objective of the Improved Eddy-Current ISI for Steam Generator Tubing program is to upgrade and validate eddy-current inspections, including probes, instrumentation, and data processing techniques for inservice inspection of new, used, and repaired steam generator tubes; to improve defect detection, classification, and characterization as affected by diameter and thickness variations, denting, probe wobble, tube sheet, tube supports, copper and sludge deposits, even when defect types and other variables occur in combination; to transfer this advanced technology to NRC`s mobile NDE laboratory and staff. This report describes the design of specialized high-speed 16-coil eddy-current array probes. Both pancake and reflection coils are considered. Test results from inspections using the probes in working steam generators are given. Computer programs developed for probe calculations are also supplied.

  17. Design of a Torque Current Generator for Strapdown Gyroscopes. Ph.D. Thesis; [and performance prediction

    NASA Technical Reports Server (NTRS)

    Mcknight, R. D.; Blalock, T. V.; Kennedy, E. J.

    1974-01-01

    The design, analysis, and experimental evaluation of an optimum performance torque current generator for use with strapdown gyroscopes, is presented. Among the criteria used to evaluate the design were the following: (1) steady-state accuracy; (2) margins of stability against self-oscillation; (3) temperature variations; (4) aging; (5) static errors drift errors, and transient errors, (6) classical frequency and time domain characteristics; and (7) the equivalent noise at the input of the comparater operational amplifier. The DC feedback loop of the torque current generator was approximated as a second-order system. Stability calculations for gain margins are discussed. Circuit diagrams are shown and block diagrams showing the implementation of the torque current generator are discussed.

  18. Piezoelectric two-dimensional nanosheets/anionic layer heterojunction for efficient direct current power generation

    PubMed Central

    Kim, Kwon-Ho; Kumar, Brijesh; Lee, Keun Young; Park, Hyun-Kyu; Lee, Ju-Hyuck; Lee, Hyun Hwi; Jun, Hoin; Lee, Dongyun; Kim, Sang-Woo

    2013-01-01

    Direct current (DC) piezoelectric power generator is promising for the miniaturization of a power package and self-powering of nanorobots and body-implanted devices. Hence, we report the first use of two-dimensional (2D) zinc oxide (ZnO) nanostructure and an anionic nanoclay layer to generate piezoelectric DC output power. The device, made from 2D nanosheets and an anionic nanoclay layer heterojunction, has potential to be the smallest size power package, and could be used to charge wireless nano/micro scale systems without the use of rectifier circuits to convert alternating current into DC to store the generated power. The combined effect of buckling behaviour of the ZnO nanosheets, a self-formed anionic nanoclay layer, and coupled semiconducting and piezoelectric properties of ZnO nanosheets contributes to efficient DC power generation. The networked ZnO nanosheets proved to be structurally stable under huge external mechanical loads. PMID:23774788

  19. High-current lanthanum-hexaboride electron emitter for a quasi-stationary arc plasma generator

    SciTech Connect

    Davydenko, V. I. Ivanov, A. A. Shul’zhenko, G. I.

    2015-11-15

    A high-current electron emitter on the basis of lanthanum hexaboride is developed for quasi-stationary arc plasma generators of ion sources. The emitter consists of a set of LaB{sub 6} washers interleaved with washers made of thermally extended graphite. The emitter is heated by the current flowing through the graphite washers. The thermal regime of emitter operation during plasma generation is considered. The emitter has been successfully used in the ion sources of the diagnostic injectors of fast hydrogen atomic beams.

  20. Efficiency of pulse high-current generator energy transfer into plasma liner energy

    NASA Astrophysics Data System (ADS)

    Oreshkin, V. I.

    2013-08-01

    The efficiency of capacitor-bank energy transfer from a high-current pulse generator into kinetic energy of a plasma liner has been analyzed. The analysis was performed using a model including the circuit equations and equations of the cylindrical shell motion. High efficiency of the energy transfer into kinetic energy of the liner is shown to be achieved only by a low-inductance generator. We considered an "ideal" liner load in which the load current is close to zero in the final of the shell compression. This load provides a high (up to 80%) efficiency of energy transfer and higher stability when compressing the liner.

  1. Oxygen suppresses light-driven anodic current generation by a mixed phototrophic culture.

    PubMed

    Darus, Libertus; Ledezma, Pablo; Keller, Jürg; Freguia, Stefano

    2014-12-02

    This paper describes the detrimental effect of photosynthetically evolved oxygen on anodic current generation in the presence of riboflavin upon illumination of a mixed phototrophic culture enriched from a freshwater pond at +0.6 V vs standard hydrogen electrode. In the presence of riboflavin, the phototrophic biomass in the anodic compartment produced an electrical current in response to light/dark cycles (12 h/12 h) over 12 months of operation, generating a maximum current density of 17.5 mA x m(-2) during the dark phase, whereas a much lower current of approximately 2 mA x m(-2) was generated during illumination. We found that the low current generation under light exposure was caused by high rates of reoxidation of reduced riboflavin by oxygen produced during photosynthesis. Quantification of biomass by fluorescence in situ hybridization images suggested that green algae were predominant in both the anode-based biofilm (55.1%) and the anolyte suspension (87.9%) with the remaining biovolume accounted for by bacteria. Genus-level sequencing analysis revealed that bacteria were dominated by cyanobacterium Leptolyngbia (∼35%), while the prevailing algae were Dictyosphaerium, Coelastrum, and Auxenochlorella. This study offers a key comprehension of mediator sensitivity to reoxidation by dissolved oxygen for improvement of microbial solar cell performance.

  2. A novel approach for generating giant electronic persistent currents in symmetric defect mesoscopic-ring networks

    NASA Astrophysics Data System (ADS)

    Hu, Xubo; Yang, Xiangbo; Deng, Dongmei

    2017-04-01

    According to optical analogy of electrons' behavior in mesoscopic systems, we change optical symmetric defect waveguide networks being able to create strong photonic localizations into electronic symmetric defect mesoscopic-ring networks (SDMRNs) being capable of generating giant electronic persistent currents. These simple SDMRNs can produce giant electronic persistent currents in the absence of magnetic field, stub, and impurity. We give out the sufficient condition for generating maximum electronic persistent current |Jp|max in SDMRNs and obtain the formula of |Jp|max. It is found that |Jp|max is proportional to the inverse square of the breaking degree of defect, Δd. Our results may deepen one's knowledge on the correlation between photonic and electronic networks and may be useful for the designing of microcircuits with large electric current.

  3. Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia.

    PubMed

    McKenna, Neil J; Howard, Christopher L; Aufiero, Michael; Easton-Marks, Jeremy; Steffen, David L; Becnel, Lauren B; Magnuson, Mark A; McIndoe, Richard A; Cartailler, Jean-Philippe

    2012-10-01

    The National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) supports multiple basic science consortia that generate high-content datasets, reagent resources, and methodologies, in the fields of kidney, urology, hematology, digestive, and endocrine diseases, as well as metabolic diseases such as diabetes and obesity. These currently include the Beta Cell Biology Consortium, the Nuclear Receptor Signaling Atlas, the Diabetic Complications Consortium, and the Mouse Metabolic Phenotyping Centers. Recognizing the synergy that would accrue from aggregating information generated and curated by these initiatives in a contiguous informatics network, we created the NIDDK Consortium Interconnectivity Network (dkCOIN; www.dkcoin.org). The goal of this pilot project, organized by the NIDDK, was to establish a single point of access to a toolkit of interconnected resources (datasets, reagents, and protocols) generated from individual consortia that could be readily accessed by biologists of diverse backgrounds and research interests. During the pilot phase of this activity dkCOIN collected nearly 2000 consortium-curated resources, including datasets (functional genomics) and reagents (mouse strains, antibodies, and adenoviral constructs) and built nearly 3000 resource-to-resource connections, thereby demonstrating the feasibility of further extending this database in the future. Thus, dkCOIN promises to be a useful informatics solution for rapidly identifying useful resources generated by participating research consortia.

  4. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1995-01-01

    Part of the 1994 Industrial Minerals Review. The production, consumption, and applications of construction aggregates are reviewed. In 1994, the production of construction aggregates, which includes crushed stone and construction sand and gravel combined, increased 7.7 percent to 2.14 Gt compared with the previous year. These record production levels are mostly a result of funding for highway construction work provided by the Intermodal Surface Transportation Efficiency Act of 1991. Demand is expected to increase for construction aggregates in 1995.

  5. Erosion of dust aggregates

    NASA Astrophysics Data System (ADS)

    Seizinger, A.; Krijt, S.; Kley, W.

    2013-12-01

    Aims: The aim of this work is to gain a deeper insight into how much different aggregate types are affected by erosion. Especially, it is important to study the influence of the velocity of the impacting projectiles. We also want to provide models for dust growth in protoplanetary disks with simple recipes to account for erosion effects. Methods: To study the erosion of dust aggregates we employed a molecular dynamics approach that features a detailed micro-physical model of the interaction of spherical grains. For the first time, the model has been extended by introducing a new visco-elastic damping force, which requires a proper calibration. Afterwards, different sample generation methods were used to cover a wide range of aggregate types. Results: The visco-elastic damping force introduced in this work turns out to be crucial to reproduce results obtained from laboratory experiments. After proper calibration, we find that erosion occurs for impact velocities of 5 ms-1 and above. Though fractal aggregates as formed during the first growth phase are most susceptible to erosion, we observe erosion of aggregates with rather compact surfaces as well. Conclusions: We find that bombarding a larger target aggregate with small projectiles results in erosion for impact velocities as low as a few ms-1. More compact aggregates suffer less from erosion. With increasing projectile size the transition from accretion to erosion is shifted to higher velocities. This allows larger bodies to grow through high velocity collisions with smaller aggregates.

  6. Analysis of non-destructive current simulators of flux compression generators

    NASA Astrophysics Data System (ADS)

    O'Connor, K. A.; Curry, R. D.

    2014-06-01

    Development and evaluation of power conditioning systems and high power microwave components often used with flux compression generators (FCGs) requires repeated testing and characterization. In an effort to minimize the cost and time required for testing with explosive generators, non-destructive simulators of an FCG's output current have been developed. Flux compression generators and simulators of FCGs are unique pulsed power sources in that the current waveform exhibits a quasi-exponential increasing rate at which the current rises. Accurately reproducing the quasi-exponential current waveform of a FCG can be important in designing electroexplosive opening switches and other power conditioning components that are dependent on the integral of current action and the rate of energy dissipation. Three versions of FCG simulators have been developed that include an inductive network with decreasing impedance in time. A primary difference between these simulators is the voltage source driving them. It is shown that a capacitor-inductor-capacitor network driving a constant or decreasing inductive load can produce the desired high-order derivatives of the load current to replicate a quasi-exponential waveform. The operation of the FCG simulators is reviewed and described mathematically for the first time to aid in the design of new simulators. Experimental and calculated results of two recent simulators are reported with recommendations for future designs.

  7. Effects of humic acid and sunlight on the generation and aggregation state of aqu/C60 nanoparticles.

    PubMed

    Isaacson, Carl W; Bouchard, Dermont C

    2010-12-01

    Aqueous suspensions of nanoscale C(60) aggregates (aqu/C(60)) were produced by stirring in water with Suwanee River Humic Acid (humic acid) and water from Call's Creek, a small stream near Athens, GA. Time course experiments were conducted to determine the effects of sunlight and solution chemistry on the mass of aqu/C(60) suspended, nanoparticle size, and ζ potential. For all treatments, sunlight had the greatest effect on the mass of aqu/C(60) suspended. The sunlight-exposed Call's Creek samples exhibited the greatest increase in mass suspended with aqu/C(60) concentrations 17 times greater than those of the dark controls, followed by the humic acid treatments, 8.1 times, and deionized water, 3.4 times. Asymmetric flow field-flow fractionation indicated that aqu/C(60) nanoparticles in humic acid were the smallest and their mass was evenly distributed in the 120-300 nm hydrodynamic diameter (D(h)) size range, whereas aqu/C(60) nanoparticles in Call's Creek water were the largest and were evenly distributed in the size range of 200-300 nm D(h). Aqu/C(60) in deionized water and humic acid treatments exposed to sunlight exhibited a trend of increasingly negative ζ potentials as suspension time increased; however, this trend was not observed for the Call's Creek treatment.

  8. Numerical simulations of current generation and dynamo excitation in a mechanically forced turbulent flow.

    PubMed

    Bayliss, R A; Forest, C B; Nornberg, M D; Spence, E J; Terry, P W

    2007-02-01

    The role of turbulence in current generation and self-excitation of magnetic fields has been studied in the geometry of a mechanically driven, spherical dynamo experiment, using a three-dimensional numerical computation. A simple impeller model drives a flow that can generate a growing magnetic field, depending on the magnetic Reynolds number Rm=micro0sigmaVa and the fluid Reynolds number Re=Vanu of the flow. For Re<420, the flow is laminar and the dynamo transition is governed by a threshold of Rmcrit=100, above which a growing magnetic eigenmode is observed that is primarily a dipole field transverse to the axis of symmetry of the flow. In saturation, the Lorentz force slows the flow such that the magnetic eigenmode becomes marginally stable. For Re>420 and Rm approximately 100 the flow becomes turbulent and the dynamo eigenmode is suppressed. The mechanism of suppression is a combination of a time varying large-scale field and the presence of fluctuation driven currents (such as those predicted by the mean-field theory), which effectively enhance the magnetic diffusivity. For higher Rm, a dynamo reappears; however, the structure of the magnetic field is often different from the laminar dynamo. It is dominated by a dipolar magnetic field aligned with the axis of symmetry of the mean-flow, which is apparently generated by fluctuation-driven currents. The magnitude and structure of the fluctuation-driven currents have been studied by applying a weak, axisymmetric seed magnetic field to laminar and turbulent flows. An Ohm's law analysis of the axisymmetric currents allows the fluctuation-driven currents to be identified. The magnetic fields generated by the fluctuations are significant: a dipole moment aligned with the symmetry axis of the mean-flow is generated similar to those observed in the experiment, and both toroidal and poloidal flux expulsion are observed.

  9. Axial Current Generation by P-Odd Domains in QCD Matter.

    PubMed

    Iatrakis, Ioannis; Lin, Shu; Yin, Yi

    2015-06-26

    The dynamics of topological domains which break parity (P) and charge-parity (CP) symmetry of QCD are studied. We derive in a general setting that those local domains will generate an axial current and quantify the strength of the induced axial current. Our findings are verified in a top-down holographic model. The relation between the real time dynamics of those local domains and the chiral magnetic field is also elucidated. We finally argue that such an induced axial current would be phenomenologically important in a heavy-ion collisions experiment.

  10. Axial current generation by P-odd domains in QCD matter

    DOE PAGES

    Iatrakis, Ioannis; Yin, Yi; Lin, Shu

    2015-06-23

    The dynamics of topological domains which break parity (P) and charge-parity (CP) symmetry of QCD are studied. We derive in a general setting that those local domains will generate an axial current and quantify the strength of the induced axial current. Thus, our findings are verified in a top-down holographic model. The relation between the real time dynamics of those local domains and the chiral magnetic field is also elucidated. We finally argue that such an induced axial current would be phenomenologically important in a heavy-ion collisions experiment.

  11. A model of a rapidly-adapting mechanosensitive current generated by a dorsal root ganglion neuron.

    PubMed

    Fujita, Kazuhisa

    2014-06-01

    I propose a model that replicates the kinetics of a rapidly-adapting mechanosensitive current generated by a dorsal root ganglion (DRG) neuron. When the DRG neuron is mechanically stimulated, an ionic current called a mechanosensitive current flows across its membrane. The kinetics of mechanosensitive currents are broadly classified into three types; rapidly adapting (RA), intermediately adapting, and slowly adapting. The kinetics of RA mechanosensitive currents are particularly intriguing. An RA mechanosensitive current is initially evoked by and rapidly adapts to a mechanical stimulus, but can also respond to an additional stimulus. Furthermore, an antecedent stimulus immediately followed by an additional stimulus suppresses reactivation of the current. The features of the kinetics depend on the characteristics of the mechanotransducer channels. Physiologists have proposed three factors associated with mechanotransducer channels, invoking activation, adaptation, and inactivation. In the present study, these factors are incorporated into an RA mechanosensitive current model. Computer simulations verified that the proposed model replicates the kinetics of real RA DRG mechanosensitive currents. The mechanosensitive current elicited by successive pulse-form stimuli was predominantly desensitized by the inactivating factor. Both the inactivating and adapting factors were involved in desensitization of a double-decker stimulus. The reduction of the sensitivity with decreasing velocity of the stimulus was mainly controlled by the adapting factor.

  12. Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells

    PubMed Central

    Hu, Hua; Vervaeke, Koen; Storm, Johan F

    2002-01-01

    Coherent network oscillations in the brain are correlated with different behavioural states. Intrinsic resonance properties of neurons provide a basis for such oscillations. In the hippocampus, CA1 pyramidal neurons show resonance at theta (θ) frequencies (2-7 Hz). To study the mechanisms underlying θ-resonance, we performed whole-cell recordings from CA1 pyramidal cells (n = 73) in rat hippocampal slices. Oscillating current injections at different frequencies (ZAP protocol), revealed clear resonance with peak impedance at 2-5 Hz at ≈33 °C (increasing to ≈7 Hz at ≈38 °C). The θ-resonance showed a U-shaped voltage dependence, being strong at subthreshold, depolarized (≈-60 mV) and hyperpolarized (≈-80 mV) potentials, but weaker near the resting potential (-72 mV). Voltage clamp experiments revealed three non-inactivating currents operating in the subthresold voltage range: (1) M-current (IM), which activated positive to -65 mV and was blocked by the M/KCNQ channel blocker XE991 (10 μm); (2) h-current (Ih), which activated negative to -65 mV and was blocked by the h/HCN channel blocker ZD7288 (10 μm); and (3) a persistent Na+ current (INaP), which activated positive to -65 mV and was blocked by tetrodotoxin (TTX, 1 μm). In current clamp, XE991 or TTX suppressed the resonance at depolarized, but not hyperpolarized membrane potentials, whereas ZD7288 abolished the resonance only at hyperpolarized potentials. We conclude that these cells show two forms of θ-resonance: ‘M-resonance’ generated by the M-current and persistent Na+ current in depolarized cells, and ‘H-resonance’ generated by the h-current in hyperpolarized cells. Computer simulations supported this interpretation. These results suggest a novel function for M/KCNQ channels in the brain: to facilitate neuronal resonance and network oscillations in cortical neurons, thus providing a basis for an oscillation-based neural code. PMID:12482886

  13. Generating electric current based on the solvent-dependent charging effects of defective boron nitride nanosheets.

    PubMed

    Que, Ronghui; Huang, Yucheng; Li, Qinling; Yao, Hong; Geng, Baoyou; Shao, Mingwang

    2014-11-26

    This work presents a method of generating electric current based on the defects of few-layer boron nitride nanosheets (BNNSs). The density functional theory calculations showed that the atomic charge of the B atom in acetone was more positive than in water. The electrostatic force microscopy measurements illustrated that the local electrical potential was 0.35 mV in acetone, while the potential signal was very difficult to capture when using water as the dispersant. This effect was further demonstrated by the performance of the acoustic energy-harvesting nanogenerator: the BNNSs were assembled into a film after being dispersed in acetone and then integrated into the generator device, generating average output current of ∼0.98 nA, which was much better than 0.2 nA, the average output current of another device with water as the dispersant. These results demonstrated that solvent effects made the as-prepared BNNSs carry net charges, which could be utilized to harvest acoustic energy and generate current.

  14. Generation of Currents in Weakly Ionized Plasmas through a Collisional Dynamo

    NASA Astrophysics Data System (ADS)

    Dimant, Yakov; Oppenheim, Meers; Fletcher, Alex

    2016-10-01

    Intense electric currents called electrojets occur in weakly ionized magnetized plasmas. An example occurs in the Earth's ionosphere near the magnetic equator where neutral winds drive the plasma across the geomagnetic field. Similar processes take place in the Solar chromosphere and MHD generators. We argue that not all convective neutral flows generate electrojets and it introduces the corresponding universal criterion for the current formation, ∇ × (U-> × B->) ≠ ∂ B-> / ∂ t , where U-> is the neutral flow velocity, B-> is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ̂ . For many systems, the displacement current, ∂ B-> / ∂ t , is negligible, making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates electrojets plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law. Work supported by NSF/DOE Grant PHY-1500439.

  15. Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells.

    PubMed

    Bittencourt, Leonardo da Silva; Zeidán-Chuliá, Fares; Yatsu, Francini Kiyono Jorge; Schnorr, Carlos Eduardo; Moresco, Karla Suzana; Kolling, Eduardo Antônio; Gelain, Daniel Pens; Bassani, Valquiria Linck; Moreira, José Cláudio Fonseca

    2014-11-01

    Advanced glycation end-products (AGEs) are considered potent molecules capable of promoting neuronal cell death and participating in the development of neurodegenerative disorders such as Alzheimer's disease (AD). Previous studies have shown that AGEs exacerbate β-amyloid (Aβ) aggregation and AGE-related cross-links are also detected in senile plaques. Acrolein (ACR) is an α, β-unsaturated aldehyde found in the environment and thermally processed foods, which can additionally be generated through endogenous metabolism. The role of ACR in AD is widely accepted in the literature. Guarana (Paullinia cupana Mart.) is popularly consumed by the population in Brazil, mainly for its stimulant activity. In the present study, we showed that guarana (10, 100, and 1000 µg/mL) is able to prevent protein glycation, β-amyloid aggregation, in vitro methylglyoxal, glyoxal, and ACR (20 μM)-induced toxicity on neuronal-like cells (SH-SY5Y). Since these are considered typical AD pathological hallmarks, we propose that guarana may deserve further research as a potential therapeutic agent in such a neurodegenerative disease.

  16. Generation of a longitudinal current upon interaction of a transverse electromagnetic wave with degenerate plasma

    NASA Astrophysics Data System (ADS)

    Latyshev, A. V.; Yushkanov, A. A.

    2017-02-01

    We consider degenerate plasma that is located in the field of a transverse electromagnetic wave. An electric current generated in the plasma by the electromagnetic field is sought. During classical description of the interaction of the electromagnetic wave with the plasma, the Vlasov kinetic equation is used, while, in quantum description, the quantum kinetic equation with the Wigner integral is applied. A nonlinear analysis has shown that that the electric current in the plasma has two nonzero components. One component of the electric current is directed along the vector potential of the electromagnetic field. The other nonzero component of the current is directed along the wave vector. In the present work, we analyze this component of the electric current. The case of collisionless plasma is examined.

  17. External ultrasound can generate microampere direct currents in vivo from implanted piezoelectric materials.

    PubMed

    Cochran, G V; Kadaba, M P; Palmieri, V R

    1988-01-01

    Under development is an internal fixation plate that incorporates a piezoelectric element to generate current when excited mechanically by either weight bearing or external application of ultrasound. The intent is to deliver this current to electrodes at a fracture or osteotomy site to aid in prevention or treatment of nonunion. The present study examines quantitatively the ability of external ultrasound to generate current from small piezoelectric ceramic elements implanted in tissue. An ultrasonic transducer (2.25 MHz, 10-20 V input, less than 10 mW/cm2 output) was employed to excite small test coupons of a piezoelectric ceramic in vitro and in vivo with various materials, including water, PVC gel, cortical bone, and living soft tissues, interposed. In all instances, it was possible to generate currents of up to 20 microA after rectification; currents up to 1 mA were achieved in some cases. The work indicates that external ultrasonic energy could effectively power small internal devices designed to stimulate bone healing, without the need for implanted batteries or percutaneous leads.

  18. Effect of thermionic cathode heating current self-magnetic field on gaseous plasma generator characteristics

    SciTech Connect

    Lopatin, I. V. Akhmadeev, Yu. H.; Koval, N. N.

    2015-10-15

    The performance capabilities of the PINK, a plasma generator with a thermionic cathode mounted in the cavity of a hollow cathode, depending for its operation on a non-self-sustained low-pressure gas discharge have been investigated. It has been shown that when a single-filament tungsten cathode 2 mm in diameter is used and the peak filament current is equal to or higher than 100 A, the self-magnetic field of the filament current significantly affects the discharge current and voltage waveforms. This effect is due to changes in the time and space distributions of the emission current density from the hot cathode. When the electron mean free path is close to the characteristic dimensions of the thermionic cathode, the synthesized plasma density distribution is nonuniform and the cathode is etched nonuniformly. The cathode lifetime in this case is 8–12 h. Using a cathode consisting of several parallel-connected tungsten filaments ∼0.8 mm in diameter moderates the effect of the self-magnetic field of the filament current and nearly doubles the cathode lifetime. The use of this type of cathode together with a discharge igniting electrode reduces the minimum operating pressure in the plasma generator to about one third of that required for the generator operation with a single-filament cathode (to 0.04 Pa)

  19. CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES: Electric-Current-Induced Heat Generation in Kondo Regime

    NASA Astrophysics Data System (ADS)

    Chen, Qiao; Zhang, Ya-Min

    2010-07-01

    Using the nonequilibrium Green's function technique, we investigate the current induced heat generation in Kondo regime. The Kondo effect influences the heat generation significantly. In the curve of heat generation versus the bias, a negative differential of the heat generation is exhibited. The symmetry of the heat generation is destroyed by the strong electron-electron interaction and the electron-phonon interaction.

  20. Three dimensional potential and current distributions in a Hall generator with assumed velocity profiles

    NASA Technical Reports Server (NTRS)

    Stankiewicz, N.; Palmer, R. W.

    1972-01-01

    Three-dimensional potential and current distributions in a Faraday segmented MHD generator operating in the Hall mode are computed. Constant conductivity and a Hall parameter of 1.0 is assumed. The electric fields and currents are assumed to be coperiodic with the electrode structure. The flow is assumed to be fully developed and a family of power-law velocity profiles, ranging from parabolic to turbulent, is used to show the effect of the fullness of the velocity profile. Calculation of the square of the current density shows that nonequilibrium heating is not likely to occur along the boundaries. This seems to discount the idea that the generator insulating walls are regions of high conductivity and are therefore responsible for boundary-layer shorting, unless the shorting is a surface phenomenon on the insulating material.

  1. Optical generation of pure spin currents at the indirect gap of bulk Si

    NASA Astrophysics Data System (ADS)

    Bottegoni, F.; Zucchetti, C.; Ciccacci, F.; Finazzi, M.; Isella, G.

    2017-01-01

    We report on the optical generation of a pure spin current at the indirect gap of bulk Si at room temperature in the photon energy range comprised between 1.2 and 1.8 eV. Spin-polarized electrons are promoted to the Δ-valleys of the Si Brillouin zone by circularly polarized light. The photo-generated spin current is then detected by exploiting a Schottky Pt/Si(001) junction: spin-polarized electrons diffuse toward the Pt/Si interface and enter the Pt layer where the spin current is converted into a transverse electromotive field through the inverse spin-Hall effect (ISHE). The photon energy dependence of the ISHE signal is interpreted in the frame of a one-dimensional spin drift-diffusion model, which allows estimating the electron spin lifetime to be τs=15 ±5 ns.

  2. Voltage-controllable generator of pure spin current: A three-terminal model

    SciTech Connect

    Ma, Zheng; Wu, Reng-Lai; Yu, Ya-Bin Wang, Miao

    2014-07-28

    Three-terminal devices have been frequently proposed to generate the pure spin current. However, the controllability and stability of pure spin current still needs to be improved. In this paper, a three-terminal device, composed of a ferromagnetic metallic lead and two nonmagnetic semiconductor leads coupled with a quantum dot, is employed to study the properties of electron spin transport. The results show that when the external voltage on one of nonmagnetic semiconductor leads is adjusted to a proper range, a pure spin current plateau or a fully spin-polarized current plateau appears in another nonmagnetic semiconductor lead. In a wide range of external voltage, the pure spin current or the spin-polarized current is kept unchanged. Since the change of temperature may considerably influence the spin-polarization of current and is inevitable actually, we studied the corresponding compensation to keep the pure spin current unchanged. Furthermore, the effect of device parameters on the pure spin current is also investigated.

  3. Spin generation via bulk spin current in three-dimensional topological insulators

    PubMed Central

    Peng, Xingyue; Yang, Yiming; Singh, Rajiv R.P.; Savrasov, Sergey Y.; Yu, Dong

    2016-01-01

    To date, spin generation in three-dimensional topological insulators is primarily modelled as a single-surface phenomenon, attributed to the momentum-spin locking on each individual surface. In this article, we propose a mechanism of spin generation where the role of the insulating yet topologically non-trivial bulk becomes explicit: an external electric field creates a transverse pure spin current through the bulk of a three-dimensional topological insulator, which transports spins between the top and bottom surfaces. Under sufficiently high surface disorder, the spin relaxation time can be extended via the Dyakonov–Perel mechanism. Consequently, both the spin generation efficiency and surface conductivity are largely enhanced. Numerical simulation confirms that this spin generation mechanism originates from the unique topological connection of the top and bottom surfaces and is absent in other two-dimensional systems such as graphene, even though they possess a similar Dirac cone-type dispersion. PMID:26932574

  4. Porous nano-structured Co3O4 anode materials generated from coordination-driven self-assembled aggregates for advanced lithium ion batteries.

    PubMed

    Ge, Danhua; Geng, Hongbo; Wang, Jiaqing; Zheng, Junwei; Pan, Yue; Cao, Xueqin; Gu, Hongwei

    2014-08-21

    A simple and scalable coordination-derived method for the synthesis of porous Co3O4 hollow nanospheres is described here. The initially formed coordination-driven self-assembled aggregates (CDSAAs) could act as the precursor followed by calcination treatment. Then the porous hollow Co3O4 nanospheres are obtained, in which the primary Co3O4 nanoparticles are inter-dispersed. When the nanospheres are used as anode materials for lithium storage, they show excellent coulombic efficiency, high lithium storage capacity and superior cycling performance. In view of the facile synthesis and excellent electrochemical performance obtained, this protocol to fabricate special porous hollow frameworks could be further extended to other metal oxides and is expected to improve the practicality of superior cycle life anode materials with large volume excursions for the development of the next generation of LIBs.

  5. Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.

    PubMed

    Mir, Abdul Rouf; Moinuddin; Habib, Safia; Khan, Farzana; Alam, Khursheed; Ali, Asif

    2016-02-01

    The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis. Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer. This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG). The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed. MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers. It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS. MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies. The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A. The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay. This reflects sharing of epitopes on MG-H2A and histones in cancer patients. The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients. Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer.

  6. Charged Dust Aggregate Interactions

    NASA Astrophysics Data System (ADS)

    Matthews, Lorin; Hyde, Truell

    2015-11-01

    A proper understanding of the behavior of dust particle aggregates immersed in a complex plasma first requires a knowledge of the basic properties of the system. Among the most important of these are the net electrostatic charge and higher multipole moments on the dust aggregate as well as the manner in which the aggregate interacts with the local electrostatic fields. The formation of elongated, fractal-like aggregates levitating in the sheath electric field of a weakly ionized RF generated plasma discharge has recently been observed experimentally. The resulting data has shown that as aggregates approach one another, they can both accelerate and rotate. At equilibrium, aggregates are observed to levitate with regular spacing, rotating about their long axis aligned parallel to the sheath electric field. Since gas drag tends to slow any such rotation, energy must be constantly fed into the system in order to sustain it. A numerical model designed to analyze this motion provides both the electrostatic charge and higher multipole moments of the aggregate while including the forces due to thermophoresis, neutral gas drag, and the ion wakefield. This model will be used to investigate the ambient conditions leading to the observed interactions. This research is funded by NSF Grant 1414523.

  7. Application of active quenching of second generation wire for current limiting

    SciTech Connect

    Solovyov, Vyacheslav F.; Li, Qiang

    2015-10-19

    Superconducting fault current limiters (SFCL's) are increasingly implemented in the power grid as a protection of substation equipment from fault currents. Resistive SFCL's are compact and light, however they are passively triggered and thus may not be sufficiently sensitive to respond to faults in the distribution grid. Here, we explore the prospect of adding an active management feature to a traditional resistive SFCL. A flexible radio-frequency coil, which is an integral part of the switching structure, acts as a triggering device. We show that the application of a short, 10 ms, burst of ac magnetic field during the fault triggers a uniform quench of the wire and significantly reduces the reaction time of the wire at low currents. The ac field burst generates a high density of normal zones, which merge into a continuous resistive region at a rate much faster than that of sparse normal zones created by the transport current alone.

  8. Application of active quenching of second generation wire for current limiting

    DOE PAGES

    Solovyov, Vyacheslav F.; Li, Qiang

    2015-10-19

    Superconducting fault current limiters (SFCL's) are increasingly implemented in the power grid as a protection of substation equipment from fault currents. Resistive SFCL's are compact and light, however they are passively triggered and thus may not be sufficiently sensitive to respond to faults in the distribution grid. Here, we explore the prospect of adding an active management feature to a traditional resistive SFCL. A flexible radio-frequency coil, which is an integral part of the switching structure, acts as a triggering device. We show that the application of a short, 10 ms, burst of ac magnetic field during the fault triggersmore » a uniform quench of the wire and significantly reduces the reaction time of the wire at low currents. The ac field burst generates a high density of normal zones, which merge into a continuous resistive region at a rate much faster than that of sparse normal zones created by the transport current alone.« less

  9. Application of active quenching of second generation wire for current limiting

    NASA Astrophysics Data System (ADS)

    Solovyov, Vyacheslav F.; Li, Qiang

    2015-12-01

    Superconducting fault current limiters (SFCLs) are increasingly implemented in the power grid as a protection of substation equipment from fault currents. Resistive SFCLs are compact and light, however they are passively triggered and thus may not be sufficiently sensitive to respond to faults in the distribution grid. Here, we explore the prospect of adding an active management feature to a traditional resistive SFCL. A flexible radio-frequency coil, which is an integral part of the switching structure, acts as a triggering device. We show that the application of a short, 10 ms, burst of ac magnetic field during the fault triggers a uniform quench of the wire and significantly reduces the reaction time of the wire at low currents. The ac field burst generates a high density of normal zones, which merge into a continuous resistive region at a rate much faster than that of sparse normal zones created by the transport current alone.

  10. Dissipation due to pure spin-current generated by spin pumping

    NASA Astrophysics Data System (ADS)

    Taniguchi, Tomohiro; Saslow, Wayne M.

    2014-12-01

    Based on spin-dependent transport theory and thermodynamics, we develop a generalized theory of the Joule heating in the presence of a spin current. Along with the conventional Joule heating consisting of an electric current and electrochemical potential, it is found that the spin current and spin accumulation give an additional dissipation because the spin-dependent scatterings inside bulk and ferromagnetic/nonmagnetic interface lead to a change of entropy. The theory is applied to investigate the dissipation due to pure spin-current generated by spin pumping across a ferromagnetic/nonmagnetic/ferromagnetic multilayer. The dissipation arises from an interface because the spin pumping is a transfer of both the spin angular momentum and the energy from the ferromagnet to conduction electrons near the interface. It is found that the dissipation is proportional to the enhancement of the Gilbert damping constant by spin pumping.

  11. Influence of electropolishing current densities on sulfur generation at niobium surface

    NASA Astrophysics Data System (ADS)

    Tyagi, P. V.; Nishiwaki, M.; Noguchi, T.; Sawabe, M.; Saeki, T.; Hayano, H.; Kato, S.

    2013-11-01

    We report the effect of different current densities on sulfur generation at Nb surface in the electropolishing (EP) with aged electrolyte. In this regard, we conducted a series of electropolishing (EP) experiments in aged EP electrolyte with high (≈50 mA/cm2) and low (≈30 mA/cm2) current densities on Nb surfaces. The experiments were carried out both for laboratory coupons and a real Nb single cell cavity with six witness samples located at three typical positions (equator, iris and beam pipe). Sample's surfaces were investigated by XPS (X-ray photoelectron spectroscopy), SEM (scanning electron microscope) and EDX (energy dispersive X-ray spectroscopy). The surface analysis showed that the EP with a high current density produced a huge amount of sulfate/sulfite particles at Nb surface whereas the EP with a low current density was very helpful to mitigate sulfate/sulfite at Nb surface in both the experiments.

  12. Generation of two-dimensional dust vortex flows in a direct current discharge plasma

    SciTech Connect

    Uchida, Giichiro; Iizuka, Satoru; Kamimura, Tetsuo; Sato, Noriyoshi

    2009-05-15

    The two-dimensional dust vortex flows are observed in a direct current discharge plasma near the edge of a metal plate which is situated in the dust-particle levitation region. Applying negative dc potential to the metal plate, dust particles are strongly accelerated toward the metal plate edge, and two symmetric dust vortex flows are generated on both sides of the metal plate. Numerical calculation including the effect of the ion drag force well demonstrates the dust vortex formation as in the experiment. A mechanism of the dust vortex generation could be explained by effect of an asymmetry of ion drag force near the metal plate.

  13. An Effect of Fault Current Limiter to Distributed Generator Shaft Torque Increase under Voltage Sag

    NASA Astrophysics Data System (ADS)

    Tanabe, Takayuki; Funabashi, Toshihisa; Otoguro, Hitomi; Martinez, Juan A.; Putrus, Ghanim; Fujita, Goro; Koyanagi, Kaoru; Yokoyama, Ryuichi

    Voltage sags originated at the transmission level can have a very adverse effect on distributed generators running at distribution levels. A fault current limiter (FCL) can be an effective means to limit the voltage sag impact. This paper presents the main results of a research based on digital simulation and aimed at studying the effectiveness of a FCL to limit the impact of voltage sag on the shaft torque of distributed generators. The sensitivity of the shaft torque to parameters of the FCL, the power system and the fault is analyzed.

  14. The Anomalous Effect of Interface Traps on Generation Current in Lightly Doped Drain nMOSFET's

    NASA Astrophysics Data System (ADS)

    Ma, Xiao-Hua; Gao, Hai-Xia; Cao, Yan-Rong; Chen, Hai-Feng; Hao, Yue

    2010-05-01

    The anomalous phenomenon of generation current IGD in the lightly doped drain (LDD) nMOSFET measured under the drain bias VD-step mode is reported. We propose an assumption of activated (A) and frozen (F) traps for the VD-step mode: The A traps contributes to IGD while the F process can make them lose the roles as generation centers. The A and F regions can form the F-A region. The comparison of the F and A regions decides the role of the F-A region. The experiments confirm the assumption.

  15. Simulation of current generations in a three-dimensional particle model

    NASA Astrophysics Data System (ADS)

    Tsung, Frank Shih-Yu

    1999-07-01

    Noninductively generated current is important for the steady state operation of tokamak plasmas. In the CCT (Continuous Current Tokamak) experiment here at UCLA, a continuous current has been observed in ECRH-generated plasmas, and in plasmas generated by electron beams, in both co- and counter-streaming cases. In 2+1/2D simulation works done by Nunan et al, a continuous toroidal current was maintained by particle fueling alone. In Nunan's work, the ``preferential loss'' model was proposed to explain the noninductive generation of toroidal currents in magnetized plasmas. However, this model assumes the conservation of the canonical toroidal momentum and therefore may not exist in three dimensional simulations. The aim of this thesis is to demonstrate this effect in a 3-D plasma model. A scalable 3-D electromagnetic PIC (Particle-in-Cell) code was developed for this purpose. Because the electromagnetic signals travels a short distance during each time-step, this code need not communicate globally and therefore has a parallel overhead independent of the number of processors. On the SP2 at Cornell Theory Center, the program is over 96% efficient on 128 nodes. Optimization techniques for RISC- based processors are also discussed. Using the parallel 3-D code, we have carried out the TDC simulations using 32 grids in the previously ignorable (toroidal) direction and 160 times as many particles as before ( 1.6˙107 particles). These 3-D calculations agree qualitatively with the 2+1/2D results. In addition, particle scans were performed in both the 2+1/2D and 3-D to identify the source of particle transport in these simulations. In addition, test particle calculations were carried out to address issues related to the TDC problem. In one test charge calculation, we showed how the curvature drift breaks up the toroidal symmetry during start-up and generates current. Because of the 1/r dependence of the curvature drift, this effect becomes important when the radius is small

  16. Generation of high-current electron beam in a wide-aperture open discharge

    NASA Astrophysics Data System (ADS)

    Bokhan, P. A.; Zakrevsky, Dm. E.; Gugin, P. P.

    2011-10-01

    In the present study, it was examined generation of nanosecond-duration electron-beam (EB) pulses by a wide-aperture open discharge burning in helium or in a mixture of helium with nitrogen and water vapor. In the experiments, a discharge cell with coaxial electrode geometry, permitting radial injection of the electron beam into operating lasing medium, was used, with the cathode having radius 2.5 cm and length 12 cm. It was shown possible to achieve an efficient generation of a high-intensity electron beam (EB pulse power ˜250 MW and EB pulse energy up to 4 J) in the kiloampere range of discharge currents (up to 26 kA at ˜12 kV discharge voltage). The current-voltage characteristics of the discharge proved to be independent of the working-gas pressure. The existence of an unstable dynamic state of EB, conditioned by the presence of an uncompensated space charge accumulated in the discharge cell due to the exponential growth of the current in time during discharge initiation and the hyperbolic growth of current density in the direction towards the tube axis, was revealed. The obtained pulsed electron beam was used to excite the self-terminated laser on He 21P10-21S0 transition. The oscillations developing in the discharge cell at high discharge currents put limit to the pumping energy and emissive power of the laser excited with the radially converging electron beam.

  17. Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

    PubMed Central

    Timofeev, Igor; Bazhenov, Maxim; Sejnowski, Terrence; Steriade, Mircea

    2002-01-01

    During paroxysmal neocortical oscillations, sudden depolarization leading to the next cycle occurs when the majority of cortical neurons are hyperpolarized. Both the Ca2+-dependent K+ currents (IK(Ca)) and disfacilitation play critical roles in the generation of hyperpolarizing potentials. In vivo experiments and computational models are used here to investigate whether the hyperpolarization-activated depolarizing current (Ih) in cortical neurons also contributes to the generation of paroxysmal onsets. Hyperpolarizing current pulses revealed a depolarizing sag in ≈20% of cortical neurons. Intracellular recordings from glial cells indirectly indicated an increase in extracellular potassium concentration ([K+]o) during paroxysmal activities, leading to a positive shift in the reversal potential of K+-mediated currents, including Ih. In the paroxysmal neocortex, ≈20% of neurons show repolarizing potentials originating from hyperpolarizations associated with depth-electroencephalogram positive waves of spike-wave complexes. The onset of these repolarizing potentials corresponds to maximal [K+]o as estimated from dual simultaneous impalements from neurons and glial cells. Computational models showed how, after the increased [K+]o, the interplay between Ih, IK(Ca), and a persistent Na+ current, INa(P), could organize paroxysmal oscillations at a frequency of 2–3 Hz. PMID:12089324

  18. ac current generation in chiral magnetic insulators and Skyrmion motion induced by the spin Seebeck effect.

    PubMed

    Lin, Shi-Zeng; Batista, Cristian D; Reichhardt, Charles; Saxena, Avadh

    2014-05-09

    We show that a temperature gradient induces an ac electric current in multiferroic insulators when the sample is embedded in a circuit. We also show that a thermal gradient can be used to move magnetic Skyrmions in insulating chiral magnets: the induced magnon flow from the hot to the cold region drives the Skyrmions in the opposite direction via a magnonic spin transfer torque. Both results are combined to compute the effect of Skyrmion motion on the ac current generation and demonstrate that Skyrmions in insulators are a promising route for spin caloritronics applications.

  19. Spontaneous dc Current Generation in a Resistively Shunted Semiconductor Superlattice Driven by a Terahertz Field

    SciTech Connect

    Alekseev, K.N.; Cannon, E.H.; McKinney, J.C.; Campbell, D.K.; Alekseev, K.N.; Kusmartsev, F.V.; Alekseev, K.N.; Kusmartsev, F.V.

    1998-03-01

    We study a resistively shunted semiconductor superlattice subject to a high-frequency electric field. Using a balance equation approach that incorporates the influence of the electric circuit, we determine numerically a range of amplitude and frequency of the ac field for which a dc bias and current are generated {ital spontaneously} and show that this region is likely accessible to current experiments. Our simulations reveal that the Bloch frequency corresponding to the spontaneous dc bias is approximately an integer multiple of the ac field frequency. {copyright} {ital 1998} {ital The American Physical Society}

  20. Generation of longitudinal current by a transverse electromagnetic field in classical and quantum plasmas

    NASA Astrophysics Data System (ADS)

    Latyshev, A. V.; Yushkanov, A. A.

    2015-09-01

    A distribution function for collisionless plasma is derived from the Vlasov kinetic equation in the quadratic approximation with respect to the electromagnetic field. Formulas for calculation of the electric current at an arbitrary temperature (arbitrary degree of degeneration of the electron gas) are deduced. The case of small wavenumbers is considered. It is shown that nonlinearity leads to the generation of an electric current directed along the wave vector. This longitudinal current is orthogonal to the classical transverse current, well known in the linear theory. A distribution function for collisionless quantum plasma is derived from the kinetic equation with the Wigner integral in the quadratic approximation with respect to the vector potential. Formulas for calculation of the electric current at an arbitrary temperature are deduced. The case of small wavenumbers is considered. It is shown that, at small values of the wavenumber, the value of the longitudinal current for quantum plasma coincides with that for classical plasma. The dimensionless currents in quantum and classical plasmas are compared graphically.

  1. Generation of longitudinal current by a transverse electromagnetic field in classical and quantum plasmas

    SciTech Connect

    Latyshev, A. V. Yushkanov, A. A.

    2015-09-15

    A distribution function for collisionless plasma is derived from the Vlasov kinetic equation in the quadratic approximation with respect to the electromagnetic field. Formulas for calculation of the electric current at an arbitrary temperature (arbitrary degree of degeneration of the electron gas) are deduced. The case of small wavenumbers is considered. It is shown that nonlinearity leads to the generation of an electric current directed along the wave vector. This longitudinal current is orthogonal to the classical transverse current, well known in the linear theory. A distribution function for collisionless quantum plasma is derived from the kinetic equation with the Wigner integral in the quadratic approximation with respect to the vector potential. Formulas for calculation of the electric current at an arbitrary temperature are deduced. The case of small wavenumbers is considered. It is shown that, at small values of the wavenumber, the value of the longitudinal current for quantum plasma coincides with that for classical plasma. The dimensionless currents in quantum and classical plasmas are compared graphically.

  2. Ultrafast proton radiography of the magnetic fields generated by a laser-driven coil current

    DOE PAGES

    Gao, Lan; Ji, Hantao; Fiksel, Gennady; ...

    2016-04-15

    Magnetic fields generated by a current flowing through a U-shaped coil connecting two copper foils were measured using ultrafast proton radiography. Two ~ 1.25 kJ, 1-ns laser pulses propagated through laser entrance holes in the front foil and were focused to the back foil with an intensity of ~ 3 x 1016 W/cm2. The intense laser-solid interaction induced a high voltage between the copper foils and generated a large current in the connecting coil. The proton data show ~ 40-50 T magnetic fields at the center of the coil ~ 3-4 ns after laser irradiation. In conclusion, the experiments providemore » significant insight for future target designs that aim to develop a powerful source of external magnetic fields for various applications in high-energy-density science.« less

  3. Ultrafast proton radiography of the magnetic fields generated by a laser-driven coil current

    SciTech Connect

    Gao, Lan; Ji, Hantao; Fiksel, Gennady; Fox, William; Evans, Michelle; Alfonso, Noel

    2016-04-15

    Magnetic fields generated by a current flowing through a U-shaped coil connecting two copper foils were measured using ultrafast proton radiography. Two ~ 1.25 kJ, 1-ns laser pulses propagated through laser entrance holes in the front foil and were focused to the back foil with an intensity of ~ 3 x 1016 W/cm2. The intense laser-solid interaction induced a high voltage between the copper foils and generated a large current in the connecting coil. The proton data show ~ 40-50 T magnetic fields at the center of the coil ~ 3-4 ns after laser irradiation. In conclusion, the experiments provide significant insight for future target designs that aim to develop a powerful source of external magnetic fields for various applications in high-energy-density science.

  4. Chemically Functionalized Conjugated Oligoelectrolyte Nanoparticles for Enhancement of Current Generation in Microbial Fuel Cells.

    PubMed

    Zhao, Cui-e; Chen, Jia; Ding, Yuanzhao; Wang, Victor Bochuan; Bao, Biqing; Kjelleberg, Staffan; Cao, Bin; Loo, Say Chye Joachim; Wang, Lianhui; Huang, Wei; Zhang, Qichun

    2015-07-08

    Water-soluble conjugated oligoelectrolyte nanoparticles (COE NPs), consisting of a cage-like polyhedral oligomeric silsesquioxanes (POSS) core equipped at each end with pendant groups (oligo(p-phenylenevinylene) electrolyte, OPVE), have been designed and demonstrated as an efficient strategy in increasing the current generation in Escherichia coli microbial fuel cells (MFCs). The as-prepared COE NPs take advantage of the structure of POSS and the optical properties of the pendant groups, OPVE. Confocal laser scanning microscopy showed strong photoluminescence of the stained cells, indicating spontaneous accumulation of COE NPs within cell membranes. Moreover, the electrochemical performance of the COE NPs is superior to that of an established membrane intercommunicating COE, DSSN+ in increasing current generation, suggesting that these COE NPs thus hold great potential to boost the performance of MFCs.

  5. Thermodynamic formula for the cumulant generating function of time-averaged current.

    PubMed

    Nemoto, Takahiro; Sasa, Shin-ichi

    2011-12-01

    The cumulant generating function of time-averaged current is studied from an operational viewpoint. Specifically, for interacting Brownian particles under nonequilibrium conditions, we show that the first derivative of the cumulant generating function is equal to the expectation value of the current in a modified system with an extra force added, where the modified system is characterized by a variational principle. The formula reminds us of Einstein's fluctuation theory in equilibrium statistical mechanics. Furthermore, since the formula leads to the fluctuation-dissipation relation when the linear response regime is focused on, it is regarded as an extension of the linear response theory to that valid beyond the linear response regime. The formula is also related to previously known theories such as the Donsker-Varadhan theory, the additivity principle, and the least dissipation principle, but it is not derived from them. Examples of its application are presented for a driven Brownian particle on a ring subject to a periodic potential.

  6. Influence of Anode Potentials on Current Generation and Extracellular Electron Transfer Paths of Geobacter Species

    PubMed Central

    Kato, Souichiro

    2017-01-01

    Geobacter species are capable of utilizing solid-state compounds, including anodic electrodes, as electron acceptors of respiration via extracellular electron transfer (EET) and have attracted considerable attention for their crucial role as biocatalysts of bioelectrochemical systems (BES’s). Recent studies disclosed that anode potentials affect power output and anodic microbial communities, including selection of dominant Geobacter species, in various BES’s. However, the details in current-generating properties and responses to anode potentials have been investigated only for a model species, namely Geobacter sulfurreducens. In this study, the effects of anode potentials on the current generation and the EET paths were investigated by cultivating six Geobacter species with different anode potentials, followed by electrochemical analyses. The electrochemical cultivation demonstrated that the G. metallireducens clade species (G. sulfurreducens and G. metallireducens) constantly generate high current densities at a wide range of anode potentials (≥−0.3 or −0.2 V vs. Ag/AgCl), while the subsurface clades species (G. daltonii, G. bemidjensis, G. chapellei, and G. pelophilus) generate a relatively large current only at limited potential regions (−0.1 to −0.3 V vs. Ag/AgCl). The linear sweep voltammetry analyses indicated that the G. metallireducens clade species utilize only one EET path irrespective of the anode potentials, while the subsurface clades species utilize multiple EET paths, which can be optimized depending on the anode potentials. These results clearly demonstrate that the response features to anode potentials are divergent among species (or clades) of Geobacter. PMID:28067820

  7. Investigation of Acoustic Fields Generated by Eddy Currents Using an Atomic Force Microscope (Postprint)

    DTIC Science & Technology

    2012-08-01

    AFRL-RX-WP-JA-2014-0230 INVESTIGATION OF ACOUSTIC FIELDS GENERATED BY EDDY CURRENTS USING AN ATOMIC FORCE MICROSCOPE (POSTPRINT) V...Institute of Physics AIR FORCE RESEARCH LABORATORY MATERIALS AND MANUFACTURING DIRECTORATE WRIGHT-PATTERSON AIR FORCE BASE, OH 45433-7750 AIR... FORCE MATERIEL COMMAND UNITED STATES AIR FORCE NOTICE AND SIGNATURE PAGE Using Government drawings, specifications, or other data included in

  8. Theoretical analysis of shock induced depolarization and current generation in ferroelectrics

    NASA Astrophysics Data System (ADS)

    Agrawal, Vinamra; Bhattacharya, Kaushik

    Ferroelectric generators are used to generate large magnitude current pulse by impacting a polarized ferroelectric material. The impact causes depolarization of the material and at high impact speeds, dielectric breakdown. Depending on the loading conditions and the electromechanical boundary conditions, the current or voltage profiles obtained vary. In this study, we explore the large deformation dynamic response of a ferroelectric material. Using the Maxwell's equations, conservation laws and the second law of thermodynamics, we derive the governing equations for the phase boundary propagation as well as the driving force acting on it. We allow for the phase boundary to contain surface charges which introduces the contribution of curvature of phase boundary in the governing equations and the driving force. This type of analysis accounts for the dielectric breakdown and resulting conduction in the material. Next, we implement the equations derived to solve a one dimensional impact problem on a ferroelectric material under different electrical boundary conditions. The constitutive law is chosen to be piecewise quadratic in polarization and quadratic in the strain. We solve for the current profile generated in short circuit case and for voltage profile in open circuited case. This work was made possible by the financial support of the US Air Force Office of Scientific Research through the Center of Excellence in High Rate Deformation Physics of Heterogeneous Materials (Grant: FA 9550-12-1-0091).

  9. Analysis of shock induced depolarization and current generation in ferroelectric ceramics

    NASA Astrophysics Data System (ADS)

    Agrawal, Vinamra; Bhattacharya, Kaushik

    2015-06-01

    Ferroelectric generators are used to generate large magnitude current pulse by impacting a polarized ferroelectric material. The impact causes depolarization of the material and at high impact speeds, dielectric breakdown. The current or voltage profiles obtained vary depending on the loading conditions. In this study, we explore the large deformation dynamic response of a ferroelectric material. Using the Maxwell's equations, conservation laws and the second law of thermodynamics, we derive the governing equations for the phase boundary propagation as well as the driving force acting on it. We allow for the phase boundary to contain surface charges which introduces the contribution of curvature of phase boundary in the governing equations and the driving force. This type of analysis accounts for the dielectric breakdown and resulting conduction in the material. Next, we implement the equations derived to solve a one dimensional impact problem on a ferroelectric material under different electrical boundary conditions. The constitutive law is chosen to be piecewise quadratic in polarization and quadratic in the strain. We solve for the current profile generated in short circuit case and for voltage profile in open circuited case. This work was made possible by the financial support of the US Air Force Office of Scientific Research through the Center of Excellence in High Rate Deformation Physics of Heterogeneous Materials (Grant: FA 9550-12-1-0091).

  10. Edge instability in a chiral stripe domain under an electric current and skyrmion generation

    DOE PAGES

    Lin, Shi -Zeng

    2016-07-05

    Motivated by the recent experimental observations on the skyrmion creation by cutting chiral stripe domains under a current drive [Jiang et al., Science 349, 283 (2015)], we study the mechanism of skyrmion generation by simulating the dynamics of stripe domains. Our theory for skyrmion generation is based on the fact that there are two half skyrmions attached to the ends of a stripe domain. These half skyrmions move due to the coupling between the skyrmion topological charge and current. As a consequence, the stripe domain is bent or stretched depending on the direction of motion of the half skyrmions. Formore » a large current, skyrmions are created by chopping the stripe domains via strong bending or stretching. Our theory provides an explanation to the experiments and is supported by the new experiments. Moreover, we predict that skyrmions can also be generated using a Bloch stripe domain under a spin transfer torque which can be realized in B20 compounds.« less

  11. Edge instability in a chiral stripe domain under an electric current and skyrmion generation

    NASA Astrophysics Data System (ADS)

    Lin, Shi-Zeng

    2016-07-01

    Motivated by the recent experimental observations on the skyrmion creation by cutting chiral stripe domains under a current drive [Jiang et al., Science 349, 283 (2015), 10.1126/science.aaa1442], we study the mechanism of skyrmion generation by simulating the dynamics of stripe domains. Our theory for skyrmion generation is based on the fact that there are two half skyrmions attached to the ends of a stripe domain. These half skyrmions move due to the coupling between the skyrmion topological charge and current. As a consequence, the stripe domain is bent or stretched depending on the direction of motion of the half skyrmions. For a large current, skyrmions are created by chopping the stripe domains via strong bending or stretching. Our theory provides an explanation to the experiments and is supported by the new experiments. Furthermore, we predict that skyrmions can also be generated using a Bloch stripe domain under a spin transfer torque which can be realized in B20 compounds.

  12. An Experimental Study on the Darrieus-Savonius Turbine for the Tidal Current Power Generation

    NASA Astrophysics Data System (ADS)

    Kyozuka, Yusaku

    The Darrieus turbine is popular for tidal current power generation in Japan. It is simple in structure with straight wings rotating around a vertical axis, so that it has no directionality against the motion of tidal flow which changes its direction twice a day. However, there is one defect in the Darrieus turbine; its small starting torque. Once it stops, a Darrieus turbine is hard to re-start until a fairly fast current is exerted on it. To improve the starting torque of the Darrieus turbine used for tidal power generation, a hybrid turbine, composed of a Darrieus turbine and a Savonius rotor is proposed. Hydrodynamic characteristics of a semi-circular section used for the Savonius bucket were measured in a wind tunnel. The torque of a two bucket Savonius rotor was measured in a circulating water channel, where four different configurations of the bucket were compared. A combined Darrieus and Savonius turbine was tested in the circulating water channel, where the effect of the attaching angle between Darrieus wing and Savonius rotor was studied. Finally, power generation experiments using a 48 pole electric generator were conducted in a towing tank and the power coefficients were compared with the results of experiments obtained in the circulating water channel.

  13. Transmit-receive eddy current probes for defect detection and sizing in steam generator tubes

    SciTech Connect

    Obrutsky, L.S.; Cecco, V.S.; Sullivan, S.P.

    1997-02-01

    Inspection of steam generator tubes in aging Nuclear Generating Stations is increasingly important. Defect detection and sizing, especially in defect prone areas such as the tubesheet, support plates and U-bend regions, are required to assess the fitness-for-service of the steam generators. Information about defect morphology is required to address operational integrity issues, i.e., risk of tube rupture, number of tubes at risk, consequential leakage. A major challenge continues to be the detection and sizing of circumferential cracks. Utilities around the world have experienced this type of tube failure. Conventional in-service inspection, performed with eddy current bobbin probes, is ineffectual in detecting circumferential cracks in tubing. It has been demonstrated in CANDU steam generators, with deformation, magnetite and copper deposits that multi-channel probes with transmit-receive eddy current coils are superior to those using surface impedance coils. Transmit-receive probes have strong directional properties, permitting probe optimization according to crack orientation. They are less sensitive to lift-off noise and magnetite deposits and possess good discrimination to internal defects. A single pass C3 array transmit-receive probe developed by AECL can detect and size circumferential stress corrosion cracks as shallow as 40% through-wall. Since its first trial in 1992, it has been used routinely for steam generator in-service inspection of four CANDU plants, preventing unscheduled shutdowns due to leaking steam generator tubes. More recently, a need has surfaced for simultaneous detection of both circumferential and axial cracks. The C5 probe was designed to address this concern. It combines transmit-receive array probe technology for equal sensitivity to axial and circumferential cracks with a bobbin probe for historical reference. This paper will discuss the operating principles of transmit-receive probes, along with inspection results.

  14. Ripple generation under the combined influences of waves and currents on the Canadian continental shelf

    NASA Astrophysics Data System (ADS)

    Amos, C. L.; Bowen, A. J.; Huntley, D. A.; Lewis, C. F. M.

    1988-10-01

    A multi-parameter instrument package ( Ralph) was deployed for 15 days in 22 m of water on Sable Island Bank, Scotian Shelf. The instrument successfully recorded mean current velocity, statistics on near-bed wave motion, wave height, period and propagation direction, and time-lapse photographs of the seabed. The seabed at the deployment site was composed of well-sorted, fine sand (0.23 mm mean diameter) which moved during peaks in tidal flow and during periods of high wave activity. Eight distinct bed types were seen in time-lapse imagery: (1) wave ripples; (2) straight-crested current ripples; (3) linguoid current ripples; (4) wave and current ripples; (5) transitional wave ripples; (6) transitional current ripples; (7) poorly developed (biodegraded) ripples; and (8) flat bed. Each bed type occurred at well-defined combinations of near-bed wave motion, mean current speed and biodegradation. Wave-current ripples intermediate in form and orientation, were not seen. Bedform types were found to be well separated in plots of wave Reynolds number (U mb·d 0/ν) and dimensionless mean flow (U 100/W s). A better separation was found if the wave Shield's parameter (after GRANT and MADSEN, 1979 , Journal of Geophysical Research, 84, 1797-1808) and the current Shield's parameter (after STERNBERG, 1972 , Shelf sediment transport, process and pattern, pp. 61-83) were used. Bedform stability plots showed that wave ripple threshold is influenced by currents, and current ripple threshold is influenced by waves. Despite this, ripple type is defined by the partitioned, wave and current components of stress and not the total stress as no intermediate (wave-current) ripple type was observed. Thresholds for sand transport and the generation of well-developed bedforms were influenced by the combined, near-bed motions of waves and currents even when the bed exhibited wave ripples or current ripples only. The threshold for sand transport under combined flows is vague, but is adequately

  15. Thermoelectric instability induced by single pulses and alternating currents in second-generation superconducting tapes

    NASA Astrophysics Data System (ADS)

    Degtyarenko, P. N.; Dul'kin, I. N.; Fisher, L. M.; Kalinov, A. V.; Voloshin, I. F.; Yampol'skii, V. A.

    2011-02-01

    We have studied current flow instabilities in a second-generation superconducting tapes and the transition of the tapes into the resistive state. Contrary to the usual quasisteady instability regimes, here we consider the adiabatic case in which the sample is heated rapidly. Two kinds of measurements of the current-voltage characteristics (CVC) have been made, specifically, with excitation of the tape by a single sinusoidal current pulse I (t)=I0sin(ωt) at different amplitudes I0 and by a continuous ac current. The main results were obtained for current amplitudes I0 exceeding the critical current Ic. We find that the dynamic CVC are essentially reversible for low amplitudes, whereas they become irreversible and acquire an N-shape for higher current amplitudes. The dynamic CVC change radically if the dissipated energy attains a threshold value Wth roughly equal to 5mJ/cm for our tapes. When this energy is reached, the tape undergoes a transition to the resistive state owing to formation of normal domains. The development of the instability with steady ac currents was studied at relatively small amplitudes such that the energy dissipated per half cycle is much lower than Wth. Even in this case, a tape undergoes a transition to the resistive state because of energy accumulation (heat pumping). With this pumping, the transition takes place after a definite number of ac cycles, when the total accumulated energy reaches the same threshold value Wth. The specific features of the dynamic CVC are interpreted qualitatively, with the appearance of resistive domains taken into account. Estimates based on the CVC agree well with our experimental data. These results can be useful in the design of superconducting fault current limiters.

  16. The generation of rapid solar flare hard X-ray and microwave fluctuations in current sheets

    NASA Astrophysics Data System (ADS)

    Holman, Gordon D.

    The generation of rapid fluctuations, or spikes, in hard X-ray and microwave bursts via the disruption of electron heating and acceleration in current sheets is studied. It is found that 20 msec hard X-ray fluctuations can be thermally generated in a current sheet if the resistivity in the sheet is highly anomalous, the plasma density in the emitting region is relatively high, and the volume of the emitting region is greater than that of the current sheet. A specific mechanism for producing the fluctuations, involving heating in the presence of ion acoustic turbulence and a constant driving electric field, and interruption of the heating by a strong two-stream instability, is discussed. Variations upon this mechanism are also discussed. This mechanism also modulates electron acceleration, as required for the microwave spike emission. If the hard X-ray emission at energies less than approx. 1000 keV is nonthermal bremsstrahlung, the coherent modulation of electron acceleration in a large number of current sheets is required.

  17. The generation of rapid solar flare hard X-ray and microwave fluctuations in current sheets

    NASA Technical Reports Server (NTRS)

    Holman, Gordon D.

    1986-01-01

    The generation of rapid fluctuations, or spikes, in hard X-ray and microwave bursts via the disruption of electron heating and acceleration in current sheets is studied. It is found that 20 msec hard X-ray fluctuations can be thermally generated in a current sheet if the resistivity in the sheet is highly anomalous, the plasma density in the emitting region is relatively high, and the volume of the emitting region is greater than that of the current sheet. A specific mechanism for producing the fluctuations, involving heating in the presence of ion acoustic turbulence and a constant driving electric field, and interruption of the heating by a strong two-stream instability, is discussed. Variations upon this mechanism are also discussed. This mechanism also modulates electron acceleration, as required for the microwave spike emission. If the hard X-ray emission at energies less than approx. 1000 keV is nonthermal bremsstrahlung, the coherent modulation of electron acceleration in a large number of current sheets is required.

  18. Gyrotron-driven high current ECR ion source for boron-neutron capture therapy neutron generator

    NASA Astrophysics Data System (ADS)

    Skalyga, V.; Izotov, I.; Golubev, S.; Razin, S.; Sidorov, A.; Maslennikova, A.; Volovecky, A.; Kalvas, T.; Koivisto, H.; Tarvainen, O.

    2014-12-01

    Boron-neutron capture therapy (BNCT) is a perspective treatment method for radiation resistant tumors. Unfortunately its development is strongly held back by a several physical and medical problems. Neutron sources for BNCT currently are limited to nuclear reactors and accelerators. For wide spread of BNCT investigations more compact and cheap neutron source would be much more preferable. In present paper an approach for compact D-D neutron generator creation based on a high current ECR ion source is suggested. Results on dense proton beams production are presented. A possibility of ion beams formation with current density up to 600 mA/cm2 is demonstrated. Estimations based on obtained experimental results show that neutron target bombarded by such deuteron beams would theoretically yield a neutron flux density up to 6·1010 cm-2/s. Thus, neutron generator based on a high-current deuteron ECR source with a powerful plasma heating by gyrotron radiation could fulfill the BNCT requirements significantly lower price, smaller size and ease of operation in comparison with existing reactors and accelerators.

  19. System and method for generating current by selective minority species heating

    DOEpatents

    Fisch, Nathaniel J.

    1983-01-01

    A system for the generation of toroidal current in a plasma which is prepared in a toroidal magnetic field. The system utilizes the injection of low-frequency waves into the plasma by means of phased antenna arrays or phased waveguide arrays. The plasma is prepared with a minority ion species of different charge state and different gyrofrequency from the majority ion species. The wave frequency and wave phasing are chosen such that the wave energy is absorbed preferentially by minority species ions traveling in one toroidal direction. The absorption of energy in this manner produces a toroidal electric current even when the injected waves themselves do not have substantial toroidal momentum. This current can be continuously maintained at modest cost in power and may be used to confine the plasma. The system can operate efficiently on fusion grade tokamak plasmas.

  20. Observation of Self-Generated Flows in Tokamak Plasmas with Lower-Hybrid-Driven Current

    SciTech Connect

    Ince-Cushman, A.; Rice, J. E.; Reinke, M.; Greenwald, M.; Wallace, G.; Parker, R.; Fiore, C.; Hughes, J. W.; Bonoli, P.; Shiraiwa, S.; Hubbard, A.; Wolfe, S.; Hutchinson, I. H.; Marmar, E.; Bitter, M.; Wilson, J.; Hill, K.

    2009-01-23

    In Alcator C-Mod discharges lower hybrid waves have been shown to induce a countercurrent change in toroidal rotation of up to 60 km/s in the central region of the plasma (r/a{approx}<0.4). This modification of the toroidal rotation profile develops on a time scale comparable to the current redistribution time ({approx}100 ms) but longer than the energy and momentum confinement times ({approx}20 ms). A comparison of the co- and countercurrent injected waves indicates that current drive (as opposed to heating) is responsible for the rotation profile modifications. Furthermore, the changes in central rotation velocity induced by lower hybrid current drive (LHCD) are well correlated with changes in normalized internal inductance. The application of LHCD has been shown to generate sheared rotation profiles and a negative increment in the radial electric field profile consistent with a fast electron pinch.

  1. ATP crossing the cell plasma membrane generates an ionic current in xenopus oocytes.

    PubMed

    Bodas, E; Aleu, J; Pujol, G; Martin-Satué, M; Marsal, J; Solsona, C

    2000-07-07

    The presence of ATP within cells is well established. However, ATP also operates as an intercellular signal via specific purinoceptors. Furthermore, nonsecretory cells can release ATP under certain experimental conditions. To measure ATP release and membrane currents from a single cell simultaneously, we used Xenopus oocytes. We simultaneously recorded membrane currents and luminescence. Here, we show that ATP release can be triggered in Xenopus oocytes by hyperpolarizing pulses. ATP release (3.2 +/- 0.3 pmol/oocyte) generated a slow inward current (2.3 +/- 0.1 microA). During hyperpolarizing pulses, the permeability for ATP(4-) was more than 4000 times higher than that for Cl(-). The sensitivity to GdCl(3) (0. 2 mm) of hyperpolarization-induced ionic current, ATP release and E-ATPase activity suggests their dependence on stretch-activated ion channels. The pharmacological profile of the current inhibition coincides with the inhibition of ecto-ATPase activity. This enzyme is highly conserved among species, and in humans, it has been cloned and characterized as CD39. The translation, in Xenopus oocytes, of human CD39 mRNA encoding enhances the ATP-supported current, indicating that CD39 is directly or indirectly responsible for the electrodiffusion of ATP.

  2. Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.

    PubMed

    Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O

    2015-12-01

    BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source.

  3. Spin-photo-currents generated by femtosecond laser pulses in a ferrimagnetic GdFeCo/Pt bilayer

    NASA Astrophysics Data System (ADS)

    Huisman, T. J.; Ciccarelli, C.; Tsukamoto, A.; Mikhaylovskiy, R. V.; Rasing, Th.; Kimel, A. V.

    2017-02-01

    Using THz emission spectroscopy, we detect spin-photo-currents from a ferrimagnetic amorphous alloy GdFeCo to an adjacent Pt capping layer. The currents are generated upon excitation of a GdFeCo/Pt heterostructure with femtosecond laser pulses. It is found that the polarization of the spin-polarized current is determined by magnetic sublattice sensitivity rather than the total magnetization, allowing for spin-polarized current generation when the net magnetization is zero.

  4. Current oscillations generated by precipitate formation in the mixing zone between two solutions inside a nanopore.

    PubMed

    Yusko, Erik C; Billeh, Yazan N; Mayer, Michael

    2010-11-17

    Unlike biological protein pores in lipid membranes, nanopores fabricated in synthetic materials can withstand a wide range of environmental conditions including the presence of organic solvents. This capability expands the potential of synthetic nanopores to monitor chemical reactions occurring at the interface between solutions of organic and aqueous character. In this work, nanopores fabricated in borosilicate glass or silicon nitride connected a predominantly organic solvent to an aqueous solvent, thereby generating a mixing zone between these solutions inside the pore. This configuration was exploited to precipitate small organic molecules with low aqueous solubility inside the nanopores, and concomitantly, to monitor this precipitation by the decrease of the ionic conductance through the nanopores over time. Hence, this method provides a means to induce and investigate the formation of nanoprecipitates or nanoparticles. Interestingly, precipitates with a slight electric charge were cleared from the pore, causing the conductance of the pore to return to its original value. This process repeated, resulting in stable oscillations of the ionic current. Although such oscillations might be useful in fluidic logic circuits, few conditions capable of generating oscillations in ionic currents have been reported. The frequency and amplitude of oscillations could be tuned by changing the concentration of the precipitating molecule, the pH of the electrolyte, and the applied potential bias. In addition to generating oscillations, nanopores that separate two different solutions may be useful for monitoring and mediating chemical reactions in the mixing zone between two solutions.

  5. Direct Measurement of Lightning Current Through a Wind-Turbine-Generator-Structure

    NASA Astrophysics Data System (ADS)

    Shiraishi, Yasuhiro; Otsuka, Takahiro

    In recent years, a wind turbine generator system is expected as one of clean energies to solve energy resources and global environmental problems. Those systems are installed in places with a strong wind. However, those places have also many winter lightning, which cause heavy damage to electric power facilities. Especially, these system in dozen of meter height are facing to severe problems such as an outage of the electric power and a maintenance check against lightning damage. In order to supply the stable energy, it is necessary to set up a lightning protection of the system. So, we developed the large diameter Rogowski coil, which can surround the steel pipe of the leg, and proved the performance by experiment. And using this Rogowski coil, we observed lightning current in some wind turbine generator systems in Japan. As the results of these observations, we got some observation data of lightning current, which struck the wind turbine generator system. This paper reports these observation techniques and results.

  6. Technique for the comparison of light spectra from natural and laboratory generated lightning current arcs

    NASA Astrophysics Data System (ADS)

    Mitchard, D.; Clark, D.; Carr, D.; Haddad, A.

    2016-08-01

    A technique was developed for the comparison of observed emission spectra from lightning current arcs generated through self-breakdown in air and the use of two types of initiation wire, aluminum bronze and nichrome, against previously published spectra of natural lightning events. A spectrograph system was used in which the wavelength of light emitted by the lightning arc was analyzed to derive elemental interactions. A lightning impulse of up to 100 kA was applied to a two hemispherical tungsten electrode configuration which allowed the effect of the lightning current and lightning arc length to be investigated. A natural lightning reference spectrum was reconstructed from literature, and generated lightning spectra were obtained from self-breakdown across a 14.0 mm air gap and triggered along initiation wires of length up to 72.4 mm. A comparison of the spectra showed that the generated lightning arc induced via self-breakdown produced a very similar spectrum to that of natural lightning, with the addition of only a few lines from the tungsten electrodes. A comparison of the results from the aluminum bronze initiation wire showed several more lines, whereas results from the nichrome initiation wire differed greatly across large parts of the spectrum. This work highlights the potential use for spectrographic techniques in the study of lightning interactions with surrounding media and materials, and in natural phenomena such as recently observed ball lightning.

  7. All-electrical generation of spin-polarized currents in quantum spin Hall insulators

    NASA Astrophysics Data System (ADS)

    Tao, L. L.; Cheung, K. T.; Zhang, L.; Wang, J.

    2017-03-01

    The control and generation of spin-polarized current (SPC) without magnetic materials and an external magnetic field is a big challenge in spintronics and normally requires a spin-flip mechanism. In this Rapid Communication, we show the theoretical discovery of all-electrical generation of SPC without relying on spin-flip spin-orbit coupling (SOC). We find that the SPC can be produced as long as an energy-dependent phase difference between the spin up and down electrons can be established. We verify this through quantum transport calculations on a gated stanene zigzag nanoribbon, which is a quantum spin Hall (QSH) insulator. Our calculations indicate that the transient current as well as ac conductance are significantly spin polarized, which results from the genetic phase difference between spin up and down electrons after traversing the system. Our results are robust against edge imperfections and generally valid for other QSH insulators, such as silicene and germanene, etc. These findings establish a different route for generating SPCs by purely electrical means and open the door for interesting applications of semiconductor spintronics.

  8. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    DOEpatents

    Bers, Abraham

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma.

  9. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    DOEpatents

    Fisch, Nathaniel J.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma.

  10. Current-Induced Generation and Synchronous Motion of Highly Packed Coupled Chiral Domain Walls.

    PubMed

    P Del Real, Rafael; Raposo, Victor; Martinez, Eduardo; Hayashi, Masamitsu

    2017-03-08

    Chiral domain walls of Neel type emerge in heterostructures that include heavy metal (HM) and ferromagnetic metal (FM) layers owing to the Dzyaloshinskii-Moriya (DM) interaction at the HM/FM interface. In developing storage class memories based on the current induced motion of chiral domain walls, it remains to be seen how dense such domain walls can be packed together. Here we show that a universal short-range repulsion that scales with the strength of the DM interaction exists among chiral domain walls. The distance between the two walls can be reduced with the application of the out-of-plane field, allowing the formation of coupled domain walls. Surprisingly, the current driven velocity of such coupled walls is independent of the out-of-plane field, enabling manipulation of significantly compressed coupled domain walls using current pulses. Moreover, we find that a single current pulse with optimum amplitude can create a large number of closely spaced domain walls. These features allow current induced generation and synchronous motion of highly packed chiral domain walls, a key feature essential for developing domain wall based storage devices.

  11. Turbidity current flow over an erodible obstacle and phases of sediment wave generation

    NASA Astrophysics Data System (ADS)

    Strauss, Moshe; Glinsky, Michael E.

    2012-06-01

    We study the flow of particle-laden turbidity currents down a slope and over an obstacle. A high-resolution 2-D computer simulation model is used, based on the Navier-Stokes equations. It includes poly-disperse particle grain sizes in the current and substrate. Particular attention is paid to the erosion and deposition of the substrate particles, including application of an active layer model. Multiple flows are modeled from a lock release that can show the development of sediment waves (SW). These are stream-wise waves that are triggered by the increasing slope on the downstream side of the obstacle. The initial obstacle is completely erased by the resuspension after a few flows leading to self consistent and self generated SW that are weakly dependant on the initial obstacle. The growth of these waves is directly related to the turbidity current being self sustaining, that is, the net erosion is more than the net deposition. Four system parameters are found to influence the SW growth: (1) slope, (2) current lock height, (3) grain lock concentration, and (4) particle diameters. Three phases are discovered for the system: (1) "no SW," (2) "SW buildup," and (3) "SW growth". The second phase consists of a soliton-like SW structure with a preserved shape. The phase diagram of the system is defined by isolating regions divided by critical slope angles as functions of current lock height, grain lock concentration, and particle diameters.

  12. Laboratory Study of Water Surface Roughness Generation by Wave-Current Interaction

    NASA Technical Reports Server (NTRS)

    Klinke, Jochen

    2000-01-01

    Within the framework of this project, the blocking of waves by inhomogeneous currents was studied. A laboratory experiment was conducted in collaboration with Steven R. Long at the linear wave tank of the NASA Air-Sea Interaction Facility, Wallops Island, VA during May 1999. Mechanically-generated waves were blocked approximately 3m upstream from the wave paddle by an opposing current. A false bottom was used to obtain a spatially varying flow field in the measurement section of the wave tank. We used an imaging slope gauge, which was mounted directly underneath the sloping section of the false tank bottom to observe the wave field. For a given current speed, the amplitude and the frequency of the waves was adjusted so that the blocking occurred within the observed footprint. Image sequences of up to 600 images at up 100 Hz sampling rate were recorded for an area of approximately 25cm x 25cm. Unlike previous measurements with wave wire gauges, the captured image sequences show the generation of the capillary waves at the blocking point and give detailed insight into the spatial and temporal evolution of the blocking process. The image data were used to study the wave-current interaction for currents from 5 to 25 cm/s and waves with frequencies between 1 and 3 Hz. First the images were calibrated with regard to size and slope. Then standard Fourier techniques as well the empirical mode decomposition method developed by Dr. Norden Huang and Dr. Steven R. Long were employed to quantify the wave number downshift from the gravity to the capillary regime.

  13. GENERATION OF ELECTRIC CURRENTS IN THE CHROMOSPHERE VIA NEUTRAL-ION DRAG

    SciTech Connect

    Krasnoselskikh, V.; Vekstein, G.; Hudson, H. S.; Bale, S. D.; Abbett, W. P.

    2010-12-01

    We consider the generation of electric currents in the solar chromosphere where the ionization level is typically low. We show that ambient electrons become magnetized even for weak magnetic fields (30 G); that is, their gyrofrequency becomes larger than the collision frequency while ion motions continue to be dominated by ion-neutral collisions. Under such conditions, ions are dragged by neutrals, and the magnetic field acts as if it is frozen-in to the dynamics of the neutral gas. However, magnetized electrons drift under the action of the electric and magnetic fields induced in the reference frame of ions moving with the neutral gas. We find that this relative motion of electrons and ions results in the generation of quite intense electric currents. The dissipation of these currents leads to resistive electron heating and efficient gas ionization. Ionization by electron-neutral impact does not alter the dynamics of the heavy particles; thus, the gas turbulent motions continue even when the plasma becomes fully ionized, and resistive dissipation continues to heat electrons and ions. This heating process is so efficient that it can result in typical temperature increases with altitude as large as 0.1-0.3 eV km{sup -1}. We conclude that this process can play a major role in the heating of the chromosphere and corona.

  14. Generation of magnetic skyrmion bubbles by inhomogeneous spin-Hall currents

    NASA Astrophysics Data System (ADS)

    Heinonen, Olle; Jiang, Wanjun; Somaily, Hamoud; Te Velthuis, Suzanne G. E.; Hoffmann, Axel

    Recent experiments have shown that magnetic skyrmion bubbles can be generated and injected at room temperature in thin films1. Here, we demonstrate, using micromagnetic modeling, that such skyrmions can be generated by an inhomogeneous spin Hall torque in the presence of Dzyaloshinskii- Moriya interactions (DMIs). In the experimental Ta-Co20Fe60B20 thin films, the DMI is rather small; nevertheless, the skyrmion bubbles are stable, or at least metastable on observational time scales. We identify two different mechanisms, one in a low-current regime and the other in a high current regime, that destabilize a domain wall injected from a narrow region into an expanding region with inhomogeneous spin-Hall torque. In the first, asymmetric torques on the domain wall lead to a cascade of bubble formation and subsequent fragmentation. In the second, an approximately steady-state texture is injected into the wide region. When the current is turned off, the inhomogeneous spin texture relaxes and regions can coalesce into bubbles that attain a definite chirality because of the DMI. This work was funded by the Department of Energy Office of Science, Materials Science and Engineering Division.

  15. Third- and fourth-generation implantable cardioverter defibrillators: current status and future development.

    PubMed

    Saksena, S; Diaz, M L; Varanasi, S; Mathew, P; Berg, J; Krol, R B; Kaushik, R R

    1994-10-01

    Implantable cardioverter defibrillator (ICD) therapy has become the mainstay of therapy for patients with a history of sudden cardiac death or life-threatening ventricular arrhythmias. The current generation of ICDs used for secondary prevention combines features for tachycardia reversion with demand ventricular pacing, antitachycardia pacing, programmable shock therapy, and tachycardia events memory. Although demand pacing and defibrillation is indicated for primary prevention usage of ICDs, the application of antitachycardia pacing modes is more controversial. High energy cardioversion and defibrillation shocks remaining the mainstay of sudden death prevention will be redefined as more effective defibrillation shock modes and lead systems are developed. Fourth-generation ICD systems accomplished a significant reduction of device size and almost universal success using an endocardial lead configuration and pectoral implant. A variety of new directions of ICD therapy in clinical practice such as primary prevention applications and the adjunctive role of antiarrhythmic drug therapy are currently being examined in clinical trials. The concepts underlying initiation of tachyarrhythmias are being studied to develop new approaches to tachycardia prevention. These include rate support, subthreshold stimulation, and multiple site pacing. The current developments of ICD therapy promise continued growth of this technology.

  16. High yield neutron generator based on a high-current gasdynamic electron cyclotron resonance ion source

    SciTech Connect

    Skalyga, V.; Sidorov, A.; Izotov, I.; Golubev, S.; Razin, S.; Strelkov, A.; Tarvainen, O.; Koivisto, H.; Kalvas, T.

    2015-09-07

    In present paper, an approach for high yield compact D-D neutron generator based on a high current gasdynamic electron cyclotron resonance ion source is suggested. Results on dense pulsed deuteron beam production with current up to 500 mA and current density up to 750 mA/cm{sup 2} are demonstrated. Neutron yield from D{sub 2}O and TiD{sub 2} targets was measured in case of its bombardment by pulsed 300 mA D{sup +} beam with 45 keV energy. Neutron yield density at target surface of 10{sup 9} s{sup −1} cm{sup −2} was detected with a system of two {sup 3}He proportional counters. Estimations based on obtained experimental results show that neutron yield from a high quality TiD{sub 2} target bombarded by D{sup +} beam demonstrated in present work accelerated to 100 keV could reach 6 × 10{sup 10} s{sup −1} cm{sup −2}. It is discussed that compact neutron generator with such characteristics could be perspective for a number of applications like boron neutron capture therapy, security systems based on neutron scanning, and neutronography.

  17. Single-layer and multilayer mirrors for current and next-generation light sources

    NASA Astrophysics Data System (ADS)

    Störmer, Michael; Horstmann, Christian; Häussler, Dietrich; Spiecker, Erdmann; Siewert, Frank; Scholze, Frank; Hertlein, Frank; Jäger, Wolfgang; Bormann, Rüdiger

    2008-08-01

    Current and next-generation light sources, for instance third generation synchrotron sources, FLASH and the future project X-FEL require single-layer and multilayer mirrors with an active optical length of more than one meter. At the GKSS research centre, a new sputtering system for the deposition of single-layer and multilayers has been installed. This new system is able to manufacture mirrors with a maximum deposition length of 1.5m. In this paper we are going to present the first results of this challenging system. The mirror properties are investigated by means of X-ray reflectometry, transmission electron microscopy and interference microscopy. The performance of the mirrors is analyzed, considering X-ray reflectivity, film thickness, micro-roughness and the uniformity of these properties over the whole deposition length. The results will be discussed and compared with former results.

  18. Generation and electric control of spin-valley-coupled circular photogalvanic current in WSe2

    NASA Astrophysics Data System (ADS)

    Yuan, Hongtao; Wang, Xinqiang; Lian, Biao; Zhang, Haijun; Fang, Xianfa; Shen, Bo; Xu, Gang; Xu, Yong; Zhang, Shou-Cheng; Hwang, Harold Y.; Cui, Yi

    2014-10-01

    The valley degree of freedom in layered transition-metal dichalcogenides provides an opportunity to extend the functionalities of spintronics and valleytronics devices. The achievement of spin-coupled valley polarization induced by the non-equilibrium charge-carrier imbalance between two degenerate and inequivalent valleys has been demonstrated theoretically and by optical experiments. However, the generation of a valley and spin current with the valley polarization in transition-metal dichalcogenides remains elusive. Here we demonstrate a spin-coupled valley photocurrent, within an electric-double-layer transistor based on WSe2, whose direction and magnitude depend on the degree of circular polarization of the incident radiation and can be further modulated with an external electric field. This room-temperature generation and electric control of a valley and spin photocurrent provides a new property of electrons in transition-metal dichalcogenide systems, and thereby enables additional degrees of control for quantum-confined spintronic devices.

  19. Population dynamics and current-generation mechanisms in cassette-electrode microbial fuel cells.

    PubMed

    Watanabe, Kazuya; Miyahara, Morio; Shimoyama, Takefumi; Hashimoto, Kazuhito

    2011-12-01

    Cassette-electrode microbial fuel cells (CE-MFCs) have been demonstrated useful to treat biomass wastes and recover electric energy from them. In order to reveal electricity-generation mechanisms in CE-MFCs, the present study operated a bench-scale reactor (1 l in capacity; approximately 1,000 cm(2) in anode and cathode areas) for treating a high-strength model organic wastewater (comprised of starch, peptone, and fish extract). Approximately 1 month was needed for the bench reactor to attain a stable performance, after which volumetric maximum power densities persisted between 120 and 150 mW/l throughout the experiment (for over 2 months). Temporal increases in the external resistance were found to induce subsequent increases in power outputs. After electric output became stable, electrolyte and anode were sampled from the reactor for evaluating their current-generation abilities; it was estimated that most of current (over 80%) was generated by microbes in the electrolyte. Cyclic voltammetry of an electrolyte supernatant detected several electron shuttles with different standard redox potentials at high concentrations (equivalent to or more than 100 μM 5-hydroxy-1,4-naphthoquinone). Denaturing gradient gel electrophoresis and quantitative real-time PCR of 16S ribosomal RNA gene fragments showed that bacteria related to the genus Dysgonomonas occurred abundantly in association with the increases in power outputs. These results suggest that mediated electron transfer was the main mechanism for electricity generation in CE-MFC, where high-concentration electron shuttles and Dysgonomonas bacteria played important roles.

  20. Generation of Ramped Current Profiles in Relativistic Electron Beams Using Wakefields in Dielectric Structures.

    PubMed

    Andonian, G; Barber, S; O'Shea, F H; Fedurin, M; Kusche, K; Swinson, C; Rosenzweig, J B

    2017-02-03

    Temporal pulse tailoring of charged-particle beams is essential to optimize efficiency in collinear wakefield acceleration schemes. In this Letter, we demonstrate a novel phase space manipulation method that employs a beam wakefield interaction in a dielectric structure, followed by bunch compression in a permanent magnet chicane, to longitudinally tailor the pulse shape of an electron beam. This compact, passive, approach was used to generate a nearly linearly ramped current profile in a relativistic electron beam experiment carried out at the Brookhaven National Laboratory Accelerator Test Facility. Here, we report on these experimental results including beam and wakefield diagnostics and pulse profile reconstruction techniques.

  1. Generation of Ramped Current Profiles in Relativistic Electron Beams Using Wakefields in Dielectric Structures

    NASA Astrophysics Data System (ADS)

    Andonian, G.; Barber, S.; O'Shea, F. H.; Fedurin, M.; Kusche, K.; Swinson, C.; Rosenzweig, J. B.

    2017-02-01

    Temporal pulse tailoring of charged-particle beams is essential to optimize efficiency in collinear wakefield acceleration schemes. In this Letter, we demonstrate a novel phase space manipulation method that employs a beam wakefield interaction in a dielectric structure, followed by bunch compression in a permanent magnet chicane, to longitudinally tailor the pulse shape of an electron beam. This compact, passive, approach was used to generate a nearly linearly ramped current profile in a relativistic electron beam experiment carried out at the Brookhaven National Laboratory Accelerator Test Facility. Here, we report on these experimental results including beam and wakefield diagnostics and pulse profile reconstruction techniques.

  2. Cesium telluride cathodes for the next generation of high-average current high-brightness photoinjectors

    SciTech Connect

    Filippetto, D. Qian, H.; Sannibale, F.

    2015-07-27

    We report on the performances of a Cs{sub 2}Te photocathode under extreme conditions of high peak time-dependent accelerating fields, continuous wave operations, and MHz pulse extraction with up to 0.3 mA average current. The measurements, performed in a normal conducting cavity, show extended lifetime and robustness, elucidate the main mechanisms for cathode degradation, and set the required system vacuum performance for compatibility with the operations of a high average power X-ray free electron laser user facility, opening the doors to the next generation of MHz-scale ultrafast scientific instruments.

  3. Generation and characterization of electron bunches with ramped current profile at the FLASH facility

    SciTech Connect

    Piot, P.; Behrens, C.; Gerth, C.; Lemery, F.; Mihalcea, D.; Vogt, M.; /DESY

    2011-09-01

    We report on the successful generation of electron bunches with current prof les that have a quasi-linear dependency on the longitudinal coordinate. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a linac operating at two frequencies (1.3 and 3.9 GHz) and a bunch compressor. Data taken for various accelerator settings demonstrate the versatility of the method. The produced bunches have parameters well matched to drive high-gradient accelerating field with enhanced transformer ratio in beam-driven accelerators based on sub-mm-sizes dielectric or plasma structures.

  4. Terahertz generation from laser-driven ultrafast current propagation along a wire target

    NASA Astrophysics Data System (ADS)

    Zhuo, H. B.; Zhang, S. J.; Li, X. H.; Zhou, H. Y.; Li, X. Z.; Zou, D. B.; Yu, M. Y.; Wu, H. C.; Sheng, Z. M.; Zhou, C. T.

    2017-01-01

    Generation of intense coherent THz radiation by obliquely incidenting an intense laser pulse on a wire target is studied using particle-in-cell simulation. The laser-accelerated fast electrons are confined and guided along the surface of the wire, which then acts like a current-carrying line antenna and under appropriate conditions can emit electromagnetic radiation in the THz regime. For a driving laser intensity ˜3 ×1018W /cm2 and pulse duration ˜10 fs, a transient current above 10 KA is produced on the wire surface. The emission-cone angle of the resulting ˜0.15 mJ (˜58 GV/m peak electric field) THz radiation is ˜30∘ . The conversion efficiency of laser-to-THz energy is ˜0.75 % . A simple analytical model that well reproduces the simulated result is presented.

  5. A new high current laboratory and pulsed homopolar generator power supply at the University of Texas

    NASA Astrophysics Data System (ADS)

    Floyd, J. E.; Aanstoos, T. A.

    1984-03-01

    The University of Texas at Austin is constructing a facility for research in pulse power technology for the Center for Electromechanics at the Balcones Research Center. The facility, designed to support high-current experiments, will be powered by six homopolar generators, each rated at 10 MJ and arranged to allow matching the requirements of resistive and inductive loads at various voltage and current combinations. Topics covered include the high bay, the power supply configuration and parameters, the speed and field control, and the magnetic circuit. Also considered are the removable air-cooled brushes, the water-cooled field coils, the hydraulic motor sizing and direct coupling, the low-impedance removable field coils, and the hydrostatic bearing design.

  6. Experimental study on hydrodynamic characteristics of vertical-axis floating tidal current energy power generation device

    NASA Astrophysics Data System (ADS)

    Ma, Yong; Li, Teng-fei; Zhang, Liang; Sheng, Qi-hu; Zhang, Xue-wei; Jiang, Jin

    2016-10-01

    To study the characteristics of attenuation, hydrostatic towage and wave response of the vertical-axis floating tidal current energy power generation device (VAFTCEPGD), a prototype is designed and experiment is carried out in the towing tank. Free decay is conducted to obtain attenuation characteristics of the VAFTCEPGD, and characteristics of mooring forces and motion response, floating condition, especially the lateral displacement of the VAFTCEPGD are obtained from the towing in still water. Tension response of the #1 mooring line and vibration characteristics of the VAFTCEPGD in regular waves as well as in level 4 irregular wave sea state with the current velocity of 0.6 m/s. The results can be reference for theoretical study and engineering applications related to VAFTCEPGD.

  7. Current noise generated by spin imbalance in presence of spin relaxation

    NASA Astrophysics Data System (ADS)

    Khrapai, V. S.; Nagaev, K. E.

    2017-01-01

    We calculate current (shot) noise in a metallic diffusive conductor generated by spin imbalance in the absence of a net electric current. This situation is modeled in an idealized three-terminal setup with two biased ferromagnetic leads (F-leads) and one normal lead (N-lead). Parallel magnetization of the F-leads gives rise in spin-imbalance and finite shot noise at the N-lead. Finite spin relaxation results in an increase of the shot noise, which depends on the ratio of the length of the conductor (L) and the spin relaxation length (l s ). For L ≫ l s the shot noise increases by a factor of two and coincides with the case of the anti-parallel magnetization of the F-leads.

  8. Polarized heat current generated by quantum pumping in two-dimensional topological insulators

    NASA Astrophysics Data System (ADS)

    Ronetti, F.; Carrega, M.; Ferraro, D.; Rech, J.; Jonckheere, T.; Martin, T.; Sassetti, M.

    2017-03-01

    We consider the transport properties of a two-dimensional topological insulator in a double quantum point contact geometry in the presence of a time-dependent external field. In the proposed setup an external gate is placed above a single constriction and it couples only with electrons belonging to the top edge. This asymmetric configuration and the presence of an ac signal allow for a quantum pumping mechanism, which, in turn, can generate finite heat and charge currents in an unbiased device configuration. A microscopic model for coupling with the external time-dependent gate potential is developed and the induced finite heat and charge currents are investigated. We demonstrate that in the noninteracting case, heat flow is associated with a single spin component, due to the helical nature of the edge states, and therefore a finite and polarized heat current is obtained in this configuration. The presence of e -e interchannel interactions strongly affects the current signal, lowering the degree of polarization of the system. Finally, we also show that separate heat and charge flows can be achieved, varying the amplitude of the external gate.

  9. An atmospheric turbulence model for spatiotemporal variability of geographically-diverse, aggregated wind-generated electricity to accelerate wide-scale wind energy deployment (Invited)

    NASA Astrophysics Data System (ADS)

    Lundquist, J. K.; Handschy, M.

    2013-12-01

    During the year 2012, the cumulative wind power capacity installed in the United States could provide roughly 4.4% of electricity demand. Although the wind resource can provide many times over the entire US electrical needs, and costs for onshore wind deployment are continually dropping, the variability of the wind represents one of the greatest remaining barriers to wide-scale wind deployment. This study focuses on the nature of this variability. We quantify the axiom 'geographic diversity reduces variability' (of wind generation) by relating resource variability characteristics to the well-understood physical phenomena of turbulence in the Earth's atmosphere. Many existing studies focus on datasets of a few years' duration in a particular geographic area; such results are difficult to generalize. Our approach builds on the fundamental nonlinear characteristics of turbulence in the atmosphere to characterize wind speed and power generation correlations between wind plants from local to continental scales. The resulting general principles enable estimation of the benefits of geographic aggregation absent detailed site-specific historical data, thereby enabling more efficient transmission grid models, expediting transmission plans, and providing a framework for evaluating the requirements and benefits of electric storage at higher wind penetrations. To validate these general principles, we compare them to observed inter-station correlations in a number of wind-speed data sets, including a 40-year Canadian dataset that spans the continent of North America, as well as shorter-duration datasets in smaller regions within the United States. This presentation will present general rules for the dependence of correlation between wind turbines on separation and time scale. We suggest these general rules could help shift renewable integration planning from simulation towards optimization.

  10. Power links with Ireland -- Excitation of turbine-generator shaft torsional vibrations by variable frequency currents superimposed on DC currents in asynchronous HVDC links

    SciTech Connect

    Hammons, T.J.; Tay, B.W.; Kok, K.L.

    1995-08-01

    The paper describes an in-depth analysis of excitation of shaft torsional vibrations in steam-turbine-generator-exciter shafts in close proximity to HVDC converter stations by variable-frequency ripple currents superimposed on the DC currents in asynchronous Links. It extends earlier work to include an in depth analysis of system scaling factors for harmonic currents impressed on generators in Northern Ireland by an inverter and to investigate the phenomena for possible torsional vibrations in the generators by the Link. Frequencies at which shaft torsional vibrations would be excited by modulation product harmonics in 50Hz/50Hz asynchronous Links as a function of deviation in system frequency is reviewed. Relative noncharacteristic current levels for 50Hz/50Hz connectors are illustrated assuming ripple currents at the inverter which gives realistic harmonic voltages in a twelve-pulse bridge. The paper then shows that torques in machines in multi-machine networks may be estimated by proportioning HVDC link harmonic disturbance current appropriately to each machine at risk. It is concluded that variable-frequency ripple currents superimposed on the DC current in asynchronous links can excite sympathetic torsional vibrations in turbine-generator-exciter shafts.

  11. Characterisation of electron currents generated by the human neutrophil NADPH oxidase

    SciTech Connect

    Ahluwalia, Jatinder

    2008-04-11

    Electron transport by the human neutrophil NADPH oxidase is an important microbicidal weapon for phagocytes. The electron current (I{sub e}) generated by the neutrophil NADPH oxidase is poorly characterised due to the lack of appropriate electrophysiological data. In this study, I fully characterise the neutrophil generated I{sub e} when the NADPH oxidase is activated by NADPH and GTP{gamma}S. The neutrophil I{sub e} was markedly voltage-dependent in the entire voltage range in comparison to those electron currents measured after chloride was removed from the external bath solution. The difference in I{sub e} measured in chloride free conditions was not due to a change in the activation kinetics of voltage-gated proton channels. The I{sub e} depolarises the neutrophil plasma membrane at a rate of 2.3 V s{sup -1} and this depolarisation was opposed when voltage-gated proton channels are activated. 3 mM ZnCl{sub 2} depolarised the membrane potential to +97.8 {+-} 2.5 mV (n = 4), and this depolarisation was abolished after NADPH oxidase inhibition.

  12. Current and next-generation bluetongue vaccines: Requirements, strategies, and prospects for different field situations.

    PubMed

    Feenstra, Femke; van Rijn, Piet A

    2017-03-01

    Bluetongue virus (BTV) causes the hemorrhagic disease bluetongue (BT) in ruminants. The best way to control outbreaks is vaccination. Currently, conventionally modified-live and inactivated vaccines are commercially available, which have been successfully used to control BT, but nonetheless have their specific shortcomings. Therefore, there is a need for improved BT vaccines. The ideal BT vaccine is efficacious, safe, affordable, protective against multiple serotypes and enables the differentiation of infected from vaccinated animals. Different field situations require specific vaccine profiles. Single serotype outbreaks in former BT-free areas need rapid onset of protection against viremia of the respective serotype. In contrary, endemic multiple serotype situations require long-lasting protection against all circulating serotypes. The ideal BT vaccine for all field situations does not exist and balancing between vaccine properties is needed. Many new vaccines candidates, ranging from non-replicating subunits to replicating next-generation reverse genetics based vaccines, have been developed. Some have been tested extensively in large numbers of ruminants, whereas others were developed recently and have only been tested in vitro and in mice models. Most vaccine candidates are promising, but have their specific shortcomings and advantages. In this review, current and next-generation BT vaccines are discussed in the light of prerequisites for different field situations.

  13. Electric current generation by sulfur-reducing bacteria in microbial-anode fuel cell

    NASA Astrophysics Data System (ADS)

    Vasyliv, Oresta M.; Bilyy, Oleksandr I.; Ferensovych, Yaroslav P.; Hnatush, Svitlana O.

    2012-10-01

    Sulfur - reducing bacteria are a part of normal microflora of natural environment. Their main function is supporting of reductive stage of sulfur cycle by hydrogen sulfide production in the process of dissimilative sulfur-reduction. At the same time these bacteria completely oxidize organic compounds with CO2 and H2O formation. It was shown that they are able to generate electric current in the two chamber microbial-anode fuel cell (MAFC) by interaction between these two processes. Microbial-anode fuel cell on the basis of sulfur- and ferric iron-reducing Desulfuromonas acetoxidans bacteria has been constructed. It has been shown that the amount of electricity generation by investigated bacteria is influenced by the concentrations of carbon source (lactate) and ferric iron chloride. The maximal obtained electric current and potential difference between electrodes equaled respectively 0.28-0.29 mA and 0.19-0.2 V per 0.3 l of bacterial suspension with 0.4 g/l of initial biomass that was grown under the influence of 0.45 mM of FeCl3 and 3 g/l of sodium lactate as primal carbon source. It has also been shown that these bacteria are resistant to different concentrations of silver ions.

  14. Experimental research of different plasma cathodes for generation of high-current electron beams

    SciTech Connect

    Shafir, G.; Kreif, M.; Gleizer, J. Z.; Gleizer, S.; Krasik, Ya. E.; Gunin, A. V.; Kutenkov, O. P.; Rostov, V. V.; Pegel, I. V.

    2015-11-21

    The results of experimental studies of different types of cathodes—carbon-epoxy rods, carbon-epoxy capillary, edged graphite, and metal-dielectric—under the application of high-voltage pulses with an amplitude of several hundreds of kV and pulse duration of several nanoseconds are presented. The best diode performance was achieved with the edged graphite and carbon-epoxy-based cathodes characterized by uniform and fast (<1 ns) formation of explosive emission plasma spots and quasi-constant diode impedance. This result was achieved for both annular cathodes in a strong magnetic field and planar cathodes of a similar diameter (∼2 cm) with no external magnetic field. The cathodes based on carbon-epoxy rods and carbon-epoxy capillaries operating with an average current density up to 1 kA/cm{sup 2} showed insignificant erosion along 10{sup 6} pulses of the generator and the generated electron beam current showed excellent reproducibility in terms of the amplitude and waveform.

  15. Start-to-end beam dynamics simulation of double triangular current profile generation in Argonne Wakefield Accelerator

    SciTech Connect

    Ha, G.; Power, J.; Kim, S. H.; Gai, W.; Kim, K.-J.; Cho, M. H.; Namkung, W.

    2012-12-21

    Double triangular current profile (DT) gives a high transformer ratio which is the determining factor of the performance of collinear wakefield accelerator. This current profile can be generated using the emittance exchange (EEX) beam line. Argonne Wakefield Accelerator (AWA) facility plans to generate DT using the EEX beam line. We conducted start-to-end simulation for the AWA beam line using PARMELA code. Also, we discuss requirements of beam parameters for the generation of DT.

  16. The Energy-Efficient Quarry: Towards improved understanding and optimisation of energy use and minimisation of CO2 generation in the aggregates industry.

    NASA Astrophysics Data System (ADS)

    Hill, Ian; White, Toby; Owen, Sarah

    2014-05-01

    Extraction and processing of rock materials to produce aggregates is carried out at some 20,000 quarries across the EU. All stages of the processing and transport of hard and dense materials inevitably consume high levels of energy and have consequent significant carbon footprints. The FP7 project "the Energy Efficient Quarry" (EE-Quarry) has been addressing this problem and has devised strategies, supported by modelling software, to assist the quarrying industry to assess and optimise its energy use, and to minimise its carbon footprint. Aggregate quarries across Europe vary enormously in the scale of the quarrying operations, the nature of the worked mineral, and the processing to produce a final market product. Nevertheless most quarries involve most or all of a series of essential stages; deposit assessment, drilling and blasting, loading and hauling, and crushing and screening. The process of determining the energy-efficiency of each stage is complex, but is broadly understood in principle and there are numerous sources of information and guidance available in the literature and on-line. More complex still is the interaction between each of these stages. For example, using a little more energy in blasting to increase fragmentation may save much greater energy in later crushing and screening, but also generate more fines material which is discarded as waste and the embedded energy in this material is lost. Thus the calculation of the embedded energy in the waste material becomes an input to the determination of the blasting strategy. Such feedback loops abound in the overall quarry optimisation. The project has involved research and demonstration operations at a number of quarries distributed across Europe carried out by all partners in the EE-Quarry project, working in collaboration with many of the major quarrying companies operating in the EU. The EE-Quarry project is developing a sophisticated modelling tool, the "EE-Quarry Model" available to the quarrying

  17. Ensemble forecasting for renewable energy applications - status and current challenges for their generation and verification

    NASA Astrophysics Data System (ADS)

    Pinson, Pierre

    2016-04-01

    The operational management of renewable energy generation in power systems and electricity markets requires forecasts in various forms, e.g., deterministic or probabilistic, continuous or categorical, depending upon the decision process at hand. Besides, such forecasts may also be necessary at various spatial and temporal scales, from high temporal resolutions (in the order of minutes) and very localized for an offshore wind farm, to coarser temporal resolutions (hours) and covering a whole country for day-ahead power scheduling problems. As of today, weather predictions are a common input to forecasting methodologies for renewable energy generation. Since for most decision processes, optimal decisions can only be made if accounting for forecast uncertainties, ensemble predictions and density forecasts are increasingly seen as the product of choice. After discussing some of the basic approaches to obtaining ensemble forecasts of renewable power generation, it will be argued that space-time trajectories of renewable power production may or may not be necessitate post-processing ensemble forecasts for relevant weather variables. Example approaches and test case applications will be covered, e.g., looking at the Horns Rev offshore wind farm in Denmark, or gridded forecasts for the whole continental Europe. Eventually, we will illustrate some of the limitations of current frameworks to forecast verification, which actually make it difficult to fully assess the quality of post-processing approaches to obtain renewable energy predictions.

  18. Current status and future prospects of power generators using dielectric elastomers

    NASA Astrophysics Data System (ADS)

    Chiba, Seiki; Waki, Mikio; Kornbluh, Roy; Pelrine, Ron

    2011-12-01

    Electroactive polymer artificial muscle (EPAM), known collectively as dielectric elastomers in the literature, has been shown to offer unique capabilities as an actuator and is now being developed for a wide variety of generator applications. EPAM has several characteristics that make it potentially well suited for wave, water current, wind, human motion, and other environmental energy harvesting systems including a high energy density allowing for minimal EPAM material quantities, high energy conversion efficiency independent of frequency of operation and non-toxic and low-cost materials not susceptible to corrosion. Experiments have been performed on push-button and heel-mounted generator devices powered by human motion, ocean wave power harvesters mounted on buoys and water turbines. While the power output levels of such demonstration devices is small, the performance of these devices has supported the potential benefits of EPAM. For example, an electrical energy conversion efficiency of over 70% was achieved with small wave heights. The ability of EPAM to produce hydrogen fuel for energy storage was also demonstrated. Because the energy conversion principle of EPAM is capacitive in nature, the performance is largely independent of size and it should eventually be possible to scale up EPAM generators to the megawatt level to address a variety of electrical power needs.

  19. Stressing of turbine-generator-exciter shafts by variable-frequency currents superimposed on DC currents in asynchronous HVDC links and following disturbances at converter stations

    SciTech Connect

    Hammons, T.J.; Bremner, J.J. )

    1994-09-01

    Ripple currents on the DC side of both HVDC synchronous and asynchronous. Links together with cleared HVDC and AC system disturbances can excite in some circumstances onerous torsional vibrations in large steam generator shafts. The problem has assumed importance in recent months on account of the HVDC Link between Scotland and Northern Ireland going ahead, on account of the proposed Eire/Wales Link, and because AC/DC/AC couplers are to be installed extensively to interconnect the East and West European Grid Systems. This paper discusses and analyses excitation of shaft torsional vibrations in steam turbine-generator-exciter shafts in close proximity to HVDC converter stations by (1) variable-frequency ripple currents superimposed on the DC currents in asynchronous Links, and (2) disturbances at bi-polar converter stations. The time response and tables show that for the systems studied variable-frequency ripple currents superimposed on the DC current in asynchronous Links can excite shaft torsional vibrations, the very small noncharacteristic currents could result in onerous shaft torques which might damage the machine, and that DC line faults at converter stations in close proximity of steam turbine-generator units can excite onerous turbine-generator shaft torsional response. Detailed simulation of the HVDC converter and generator is necessary for precise assessments of shaft torsional response following HVDC converter station faults. 500MW, 660MW, 1000MW and 1300MW machines are considered in the analyses that are made.

  20. Pulsed eddy current inspection of broach support plates in steam generators

    NASA Astrophysics Data System (ADS)

    Mokros, Sarah Gwendolyn

    Steam Generators (SGs) are a critical component of nuclear reactors, employing thousands of SG tubes to convert heat generated in the reactor core into useable energy. SG tubes are supported at numerous locations by Broach Support Plates (BSPs) that have trefoil shaped holes, which prevent excessive tube vibrations, while allowing water to easily flow through the support structures. A number of degradation modes occur in SGs, such as SG tube fretting, cracking or denting, requiring periodic inspection. Currently, conventional Eddy Current Testing (ECT) is used to non-destructively assess the condition of SG tubes and components. However, as reactors age, new modes of degradation will likely appear that may be difficult to detect and characterize using conventional ECT, such as wall loss in BSPs and build-up of corrosion products, which typically form as a hard sludge called magnetite. Pulsed Eddy Current (PEC) technologies are an emerging technique that is presented in this work as a method to further advance inspection techniques used in CANDURTM nuclear reactors. A PEC probe was designed to inspect the unique shape of the trefoil shaped hole to detect and characterize wall loss and the presence of magnetite in A516 carbon steel BSPs with trefoil shaped holes from within 15.9 mm (5/8") Alloy-800 SG tubes. PEC was also used to observe how measurements of wall loss were affected by the presence of magnetite. This work presents Finite Element Method (FEM) simulations and experimental results collected to observe these degradation modes. The probe was demonstrated to be capable of detecting far side wall loss as low as 20%, locating and characterizing the relative permeability of magnetite, and of detecting wall loss when magnetite was present. FEM simulations and experimental results were found to be in good agreement, suggesting that additional investigations of the effects of BSP degradation on PEC signal response may also be performed using FEM models.

  1. Fibronectin Aggregation and Assembly

    PubMed Central

    Ohashi, Tomoo; Erickson, Harold P.

    2011-01-01

    The mechanism of fibronectin (FN) assembly and the self-association sites are still unclear and contradictory, although the N-terminal 70-kDa region (I1–9) is commonly accepted as one of the assembly sites. We previously found that I1–9 binds to superfibronectin, which is an artificial FN aggregate induced by anastellin. In the present study, we found that I1–9 bound to the aggregate formed by anastellin and a small FN fragment, III1–2. An engineered disulfide bond in III2, which stabilizes folding, inhibited aggregation, but a disulfide bond in III1 did not. A gelatin precipitation assay showed that I1–9 did not interact with anastellin, III1, III2, III1–2, or several III1–2 mutants including III1–2KADA. (In contrast to previous studies, we found that the III1–2KADA mutant was identical in conformation to wild-type III1–2.) Because I1–9 only bound to the aggregate and the unfolding of III2 played a role in aggregation, we generated a III2 domain that was destabilized by deletion of the G strand. This mutant bound I1–9 as shown by the gelatin precipitation assay and fluorescence resonance energy transfer analysis, and it inhibited FN matrix assembly when added to cell culture. Next, we introduced disulfide mutations into full-length FN. Three disulfide locks in III2, III3, and III11 were required to dramatically reduce anastellin-induced aggregation. When we tested the disulfide mutants in cell culture, only the disulfide bond in III2 reduced the FN matrix. These results suggest that the unfolding of III2 is one of the key factors for FN aggregation and assembly. PMID:21949131

  2. Spin current generation from sputtered Y₃Fe₅O₁₂ films

    SciTech Connect

    Lustikova, J. Shiomi, Y.; Kikkawa, T.; Iguchi, R.; Qiu, Z.; Uchida, K.; Saitoh, E.

    2014-10-21

    Spin current injection from sputtered yttrium iron garnet (YIG) films into an adjacent platinum layer has been investigated by means of the spin pumping and the spin Seebeck effects. Films with a thickness of 83 and 96 nanometers were fabricated by on-axis magnetron rf sputtering at room temperature and subsequent post-annealing. From the frequency dependence of the ferromagnetic resonance linewidth, the damping constant has been estimated to be (7.0 ± 1.0) × 10⁻⁴. Magnitudes of the spin current generated by the spin pumping and the spin Seebeck effect are of the same order as values for YIG films prepared by liquid phase epitaxy. The efficient spin current injection can be ascribed to a good YIG|Pt interface, which is confirmed by the large spin-mixing conductance (2.0 ± 0.2) × 10¹⁸m⁻².

  3. Time-dependent modeling of field-aligned current-generated ion transients in the polar wind

    NASA Technical Reports Server (NTRS)

    Gombosi, T. I.; Nagy, A. F.

    1989-01-01

    The time evolution of field-aligned current-generated transient features in the high-latitude ionosphere is investigated. Ionospheric return currents generate significant downward heavy ion flows in the topside ionosphere with peak values well exceeding 10 to the 8th sq cm/s. When the return current ceases, the polar ionosphere rapidly returns to its previous equilibrium state. During the recovery phase of the return current event, an upward propagating heavy ion transient is formed, which is mainly characterized by a relatively short O(+) upwelling event. On the other hand, the H(+) escape flux remains relatively constant (within 10-20 percent) during field-aligned current events. It is also found that upward currents generate a transient heavy ion outflow, which exceeds the ambient H(+) escape flux by a factor of 3 to 5, depending on the duration and strength of the field-aligned current event.

  4. Outlook for the use of microsecond plasma opening switches to generate high-power nanosecond current pulses

    NASA Astrophysics Data System (ADS)

    Dolgachev, G. I.; Maslennikov, D. D.; Ushakov, A. G.

    2006-12-01

    An analysis is made of the current break process in microsecond plasma opening switches and their possible application in high-current generators. Necessary conditions are determined for generating megavolt pulses in the erosion mode of a plasma opening switch with the gap insulated by an external magnetic field. Under these conditions, efficient sharpening of high-power submegampere current pulses can be achieved. The possibility of using plasma opening switches operating at voltages of 5 6 MV to generate X-ray and gamma emission is discussed. The main operating and design parameters of a six-module plasma opening switch with a current pulse amplitude of 3.7 MA and voltage of 4 6 MV for use in the MOL generator, which is the prototype of one of the 24 modules of the projected Baikal multimegajoule generator, are estimated by using the available scalings.

  5. Mechanism of generation of spontaneous miniature outward currents (SMOCs) in retinal amacrine cells.

    PubMed

    Mitra, Pratip; Slaughter, Malcolm M

    2002-04-01

    A subtype of retinal amacrine cells displayed a distinctive array of K(+) currents. Spontaneous miniature outward currents (SMOCs) were observed in the narrow voltage range of -60 to -40 mV. Depolarizations above approximately -40 mV were associated with the disappearance of SMOCs and the appearance of transient (I(to)) and sustained (I(so)) outward K(+) currents. I(to) appeared at about -40 mV and its apparent magnitude was biphasic with voltage, whereas I(so) appeared near -30 mV and increased linearly. SMOCs, I(to), and a component of I(so) were Ca(2+) dependent. SMOCs were spike shaped, occurred randomly, and had decay times appreciably longer than the time to peak. In the presence of cadmium or cobalt, SMOCs with pharmacologic properties identical to those seen in normal Ringer's could be generated at voltages of -20 mV and above. Their mean amplitude was Nernstian with respect to [K(+)](ext) and they were blocked by tetraethylammonium. SMOCs were inhibited by iberiotoxin, were insensitive to apamin, and eliminated by nominally Ca(2+)-free solutions, indicative of BK-type Ca(2+)-activated K(+) currents. Dihydropyridine Ca(2+) channel antagonists and agonists decreased and increased SMOC frequencies, respectively. Ca(2+) permeation through the kainic acid receptor had no effect. Blockade of organelle Ca(2+) channels by ryanodine, or intracellular Ca(2+) store depletion with caffeine, eradicated SMOCs. Internal Ca(2+) chelation with 10 mM BAPTA eliminated SMOCs, whereas 10 mM EGTA had no effect. These results suggest a mechanism whereby Ca(2+) influx through L-type Ca(2+) channels and its subsequent amplification by Ca(2+)-induced Ca(2+) release via the ryanodine receptor leads to a localized elevation of internal Ca(2+). This amplified Ca(2+) signal in turn activates BK channels in a discontinuous fashion, resulting in randomly occurring SMOCs.

  6. Construction aggregates

    USGS Publications Warehouse

    Nelson, T.I.; Bolen, W.P.

    2007-01-01

    Construction aggregates, primarily stone, sand and gravel, are recovered from widespread naturally occurring mineral deposits and processed for use primarily in the construction industry. They are mined, crushed, sorted by size and sold loose or combined with portland cement or asphaltic cement to make concrete products to build roads, houses, buildings, and other structures. Much smaller quantities are used in agriculture, cement manufacture, chemical and metallurgical processes, glass production and many other products.

  7. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1996-01-01

    Part of the Annual Commodities Review 1995. Production of construction aggregates such as crushed stone and construction sand and gravel showed a marginal increase in 1995. Most of the 1995 increases were due to funding for highway construction work. The major areas of concern to the industry included issues relating to wetlands classification and the classification of crystalline silica as a probable human carcinogen. Despite this, an increase in demand is anticipated for 1996.

  8. Analysis of variable-frequency currents superimposed on DC currents in asynchronous HVDC Links in stressing turbine-generator-exciter shafts

    SciTech Connect

    Hammons, T.J.; Bremner, J.J.

    1995-03-01

    Ripple currents on the DC side of both HVDC asynchronous and synchronous Links can excite in some circumstances onerous torsional vibrations in large steam generator shafts. The problem has assumed importance in recent months on account of the HVDC Link between Scotland and Northern Ireland going ahead, on account of the proposed Eire/Wales Link, because AC/DC/AC couplers are to be installed to interconnect the East and West European Grid Systems, and because resonances have been observed on machines in close proximity to AC/DCIAC couplers and HVDC Links. This paper discusses and analyses excitation of shaft torsional vibrations in steam turbine-generator-exciter shafts in close proximity to HVDC converter stations by variable-frequency ripple currents superimposed on DC currents in asynchronous Links. It presents technical knowledge not arranged for convenient reference heretofore in studying possible excitation of turbine-generator-v/ exciter shaft torsional vibrations by non-characteristic HVDC converter harmonic currents if a machine should be considered to be at risk. Shaft torques in multi-machine networks are evaluated by proportioning HVDC Link disturbance currents to each machine at risk using system network data, generator data and fault analysis data considering frequency dependence of the system parameters. This scaling factor is calculated for different scenarios of system operation and load. Equivalent circuits for the synchronous generator are employed appropriately to correlate HVDC Link disturbance current impressed on the generator stator with s state torque excitation from which magnitude of turbine-generator-exciter shaft torque is deduced.

  9. Enhanced labeling of microalgae cellular lipids by application of an electric field generated by alternating current.

    PubMed

    Su, Li-Chien; Hsu, Yi-Hsiang; Wang, Hsiang-Yu

    2012-05-01

    An alternating current was used to generate an electric field to enhance the fluorescent labeling of microalgae cellular lipids with Nile red and LipidTOX. The decay of the fluorescence intensity of Chlorella vulgaris cells in 0 V/cm was more than 50% after 10 min, and the intensity variation was as high as 7% in 20s. At 2000 V/cm, the decay rate decreased to 1.22% per minute and the intensity fluctuation was less than 1% for LipidTOX-labeled cells. For Spirulina sp. cells at 0 V/cm, the fluorescence intensity increased by 10% after 10 min, whereas at 2000 V/cm, labeling was more rapid and fluorescence intensity doubled. These results show that applying an electric field can improve the quality of fluorescence detection by alleviating decay and fluctuation or by enhancing signal intensity.

  10. Performance demonstration tests for eddy current inspection of steam generator tubing

    SciTech Connect

    Kurtz, R.J.; Heasler, P.G.; Anderson, C.M.

    1996-05-01

    This report describes the methodology and results for development of performance demonstration tests for eddy current (ET) inspection of steam generator tubes. Statistical test design principles were used to develop the performance demonstration tests. Thresholds on ET system inspection performance were selected to ensure that field inspection systems would have a high probability of detecting and and correctly sizing tube degradation. The technical basis for the ET system performance thresholds is presented in detail. Statistical test design calculations for probability of detection and flaw sizing tests are described. A recommended performance demonstration test based on the design calculations is presented. A computer program for grading the probability of detection portion of the performance demonstration test is given.

  11. Particle Diffusion in Chaotic Magnetic Fields Generated by Asymmetric Current Configurations

    NASA Astrophysics Data System (ADS)

    Ram, A. K.; Dasgupta, B.

    2008-12-01

    The observed cross-field diffusion of charged particles in cosmic rays is assumed to be due to the chaotic nature of the interplanetary/intergalactic magnetic fields. Among the classic works on this subject have been those of Parker [1] and Jokipii [2]. Parker considered the passage of cosmic ray particles and energetic solar particles in a large scale magnetic field containing small scale irregularities. In the context of cosmic ray propagation, Jokipii considered a small fluctuating component, added on to a uniform magnetic field, to study the spatial transport of particles. In these studies the irregular component of the magnetic field is prescribed in an ad hoc fashion. In contrast, we consider asymmetric, nonlinear, steady-state magnetic fields, in three spatial dimensions, generated by currents flowing in circular loops and straight lines [3]. These magnetic fields are completely deterministic and, for certain range of parameters, chaotic. We will present analytical and numerical studies on the spatial characteristics of these fields. The motion of charged particles in the nonlinear and chaotic magnetic fields is determined using the Lorentz equation. A particle moving in a deterministic chaotic magnetic field superposed on a uniform background magnetic field is found to undergo spatial transport. This shows that chaotic magnetic fields generated by simple current configurations can produce cross-field diffusion. A detailed analysis of particle motion and diffusion along with application to space plasmas will be presented. [1] E.N. Parker, Planet. Space Sci. 13, 9 (1965). [2] J.R. Jokipii, Astrophys. J. 146, 480 (1966), and J.R. Jokipii, Astrophys. J. 149, 405 (1967). [3] A.K. Ram and B. Dasgupta, Eos Trans. AGU 87 (52), Fall Meet. Suppl. Abstract NG31B-1593 (2006); and Eos Trans. AGU 88 (52), Fall Meet. Suppl. Abstract NG21B-0522 (2007).

  12. Generation and electric control of spin-valley-coupled circular photogalvanic current in WSe2

    NASA Astrophysics Data System (ADS)

    Yuan, Hongtao; Hwang, Harold Y.; Cui, Yi

    2015-03-01

    Compared to the weak spin-orbit-interaction (SOI) in graphene, layered transitionmetal chalcogenides MX2 have heavy 4d/5d elements with strong atomic SOI, providing a unique way to extend functionalities of novel spintronics and valleytronics devices. Such a valley polarization achieved via valley-selective circular dichroism has been predicted theoretically and demonstrated with optical experiments in MX2 systems. Despite the exciting progresses, the generation of a valley/spin current by valley polarization in MX2 remains elusive and a great challenge. A spin/valley current in MX2 compounds caused by such a valley polarization has never been observed, nor its electric-field control. In this talk, we demonstrated, within an electric-double-layer transistor based on WSe2, the manipulation of a spin-coupled valley photocurrent whose direction and magnitude depend on the degree of circular polarization of the incident radiation and can be further greatly modulated with an external electric field. Such room temperature generation and electric control of valley/spin photocurrent provides a new property of electrons in MX2 systems, thereby enabling new degrees of control for quantum-confined spintronics devices. (In collaboration with S.C. Zhang, Y.L. Chen, Z.X. Shen, B Lian, H.J. Zhang, G Xu, Y Xu, B Zhou, X.Q. Wang, B Shen X.F. Fang) Acknowledge the support from DoE, BES, Division of MSE under contract DE-AC02-76SF00515. Acknowledge the support from DoE, BES, Division of MSE under contract DE-AC02-76SF00515.

  13. Nitric oxide generation by endothelial cells exposed to shear stress in glass tubes perfused with red blood cell suspensions: role of aggregation.

    PubMed

    Yalcin, Ozlem; Ulker, Pinar; Yavuzer, Ugur; Meiselman, Herbert J; Baskurt, Oguz K

    2008-05-01

    Endothelial function is modulated by wall shear stress acting on the vessel wall, which is determined by fluid velocity and the local viscosity near the vessel wall. Red blood cell (RBC) aggregation may affect the local viscosity by favoring axial migration. The aim of this study was to investigate the role of RBC aggregation, with or without altered plasma viscosity, in the mechanically induced nitric oxide (NO)-related mechanisms of endothelial cells. Human umbilical vein endothelial cells (HUVEC) were cultured on the inner surface of cylindrical glass capillaries that were perfused with RBC suspensions having normal and increased aggregation at a nominal shear stress of 15 dyn/cm(2). RBC aggregation was enhanced by two different approaches: 1) poloxamer-coated RBC suspended in normal, autologous plasma, resulting in enhanced aggregation but unchanged plasma viscosity and 2) normal RBC suspended in autologous plasma containing 0.5% dextran (mol mass 500 kDa), with a similar level of RBC aggregation but higher plasma viscosity. Compared with normal cells in unmodified plasma, perfusion with suspensions of poloxamer-coated RBC in normal plasma resulted in decreased levels of NO metabolites and serine 1177 phosphorylation of endothelial nitric oxide synthase (eNOS). Perfusion with normal RBC in plasma containing dextran resulted in a NO level that remained elevated, whereas only a modest decrease of phosphorylated eNOS level was observed. The results of this study suggest that increases of RBC aggregation tendency affect endothelial cell functions by altering local blood composition, especially if the alterations of RBC aggregation are due to modified cellular properties and not to plasma composition changes.

  14. Wolf (Canis lupus) Generation Time and Proportion of Current Breeding Females by Age

    PubMed Central

    2016-01-01

    Information is sparse about aspects of female wolf (Canis lupus) breeding in the wild, including age of first reproduction, mean age of primiparity, generation time, and proportion of each age that breeds in any given year. We studied these subjects in 86 wolves (113 captures) in the Superior National Forest (SNF), Minnesota (MN), during 1972–2013 where wolves were legally protected for most of the period, and in 159 harvested wolves from throughout MN wolf range during 2012–2014. Breeding status of SNF wolves were assessed via nipple measurements, and wolves from throughout MN wolf range, by placental scars. In the SNF, proportions of currently breeding females (those breeding in the year sampled) ranged from 19% at age 2 to 80% at age 5, and from throughout wolf range, from 33% at age 2 to 100% at age 7. Excluding pups and yearlings, only 33% to 36% of SNF females and 58% of females from throughout MN wolf range bred in any given year. Generation time for SNF wolves was 4.3 years and for MN wolf range, 4.7 years. These findings will be useful in modeling wolf population dynamics and in wolf genetic and dog-domestication studies. PMID:27258193

  15. Second-generation prophylactic HPV vaccines: current options and future strategies for vaccines development.

    PubMed

    Fruscalzo, Arrigo; Londero, Ambrogio P; Bertozzi, Serena; Lellè, Ralf J

    2016-02-01

    Two vaccines focused on the prevention of HPV-related diseases have been introduced in the last decade, the quadrivalent vaccine Gardasil and the bivalent vaccine Cervarix. They are targeted to prevent precancerous and cancerous lesions not only of the cervix, but also of the vulva, vagina, anal and head-neck region. Furthermore, the protection of the quadrivalent vaccine Gardasil includes also genital warts and recurrent respiratory Papillomatosis, two benign conditions with high socio-economic impact. Although their efficacy in reducing the burden of HPV-related pathologies has been already documented, second-generation HPV vaccines are being developed in order to overcome major limitations, above all the cost of production, distribution and acceptance, thus promoting an easier access to vaccination, especially in developing countries. Recently a new multivalent VLP vaccine active against nine HPV subtypes, called Gardasil 9 (Merck & Co., Inc., Whitehouse Station, NJ, USA), has been approved, showing promising preliminary results. In this article, we outline the strategies adopted for second-generation HPV vaccine engineering, the latest HPV vaccines available at this time, as well as those currently in development.

  16. Spin-current-driven thermoelectric generation based on interfacial spin-orbit coupling

    NASA Astrophysics Data System (ADS)

    Yagmur, A.; Karube, S.; Uchida, K.; Kondou, K.; Iguchi, R.; Kikkawa, T.; Otani, Y.; Saitoh, E.

    2016-06-01

    The longitudinal spin Seebeck effect (SSE) in Bi2O3/Cu/yttrium-iron-garnet (YIG) devices has been investigated. When an out-of-plane temperature gradient is applied to the Bi2O3/Cu/YIG device, a spin current is generated across the Cu/YIG interface via the SSE and then converted into electric voltage due to the spin-orbit coupling at the Bi2O3/Cu interface. The sign of the SSE voltage in the Bi2O3/Cu/YIG devices is opposite to that induced by the conventional inverse spin Hall effect in Pt/YIG devices. The SSE voltage in the Bi2O3/Cu/YIG devices disappears in the absence of the Bi2O3 layer and its thermoelectric conversion efficiency is independent of the Cu thickness, indicating the important role of the Bi2O3/Cu interface. This result demonstrates that not only the bulk inverse spin Hall effect but also the spin-orbit coupling near the interface can be used for SSE-based thermoelectric generation.

  17. Current protocols in the generation of pluripotent stem cells: theoretical, methodological and clinical considerations

    PubMed Central

    Swelstad, Brad B; Kerr, Candace L

    2010-01-01

    Pluripotent stem cells have been derived from various embryonic, fetal and adult sources. Embryonic stem cells (ESCs) and parthenogenic ESCs (pESCs) are derived from the embryo proper while embryonic germ cells (EGCs), embryonal carcinoma cells (ECCs), and germ-line stem cells (GSC) are produced from germ cells. ECCs were the first pluripotent stem cell lines established from adult testicular tumors while EGCs are generated in vitro from primordial germ cells (PGCs) isolated in late embryonic development. More recently, studies have also demonstrated the ability to produce GSCs from adult germ cells, known as spermatogonial stem cells. Unlike ECCs, the source of GSCs are normal, non-cancerous adult tissue. The study of these unique cell lines has provided information that has led to the ability to reprogram somatic cells into an ESC-like state. These cells, called induced pluripotent stem cells (iPSCs), have been derived from a number of human fetal and adult origins. With the promises pluripotent stem cells bring to cell-based therapies there remain several considerations that need to be carefully studied prior to their clinical use. Many of these issues involve understanding key factors regulating their generation, including those which define pluripotency. In this regard, the following article discusses critical aspects of pluripotent stem cell derivation and current issues about their therapeutic potential. PMID:24198508

  18. Wolf (Canis lupus) generation time and proportion of current breeding females by age

    USGS Publications Warehouse

    Mech, L. David; Barber-Meyer, Shannon M.; Erb, John

    2016-01-01

    Information is sparse about aspects of female wolf (Canis lupus) breeding in the wild, including age of first reproduction, mean age of primiparity, generation time, and proportion of each age that breeds in any given year. We studied these subjects in 86 wolves (113 captures) in the Superior National Forest (SNF), Minnesota (MN), during 1972–2013 where wolves were legally protected for most of the period, and in 159 harvested wolves from throughout MN wolf range during 2012–2014. Breeding status of SNF wolves were assessed via nipple measurements, and wolves from throughout MN wolf range, by placental scars. In the SNF, proportions of currently breeding females (those breeding in the year sampled) ranged from 19% at age 2 to 80% at age 5, and from throughout wolf range, from 33% at age 2 to 100% at age 7. Excluding pups and yearlings, only 33% to 36% of SNF females and 58% of females from throughout MN wolf range bred in any given year. Generation time for SNF wolves was 4.3 years and for MN wolf range, 4.7 years. These findings will be useful in modeling wolf population dynamics and in wolf genetic and dog-domestication studies.

  19. Analysis of pulsed eddy current data using regression models for steam generator tube support structure inspection

    NASA Astrophysics Data System (ADS)

    Buck, J. A.; Underhill, P. R.; Morelli, J.; Krause, T. W.

    2016-02-01

    Nuclear steam generators (SGs) are a critical component for ensuring safe and efficient operation of a reactor. Life management strategies are implemented in which SG tubes are regularly inspected by conventional eddy current testing (ECT) and ultrasonic testing (UT) technologies to size flaws, and safe operating life of SGs is predicted based on growth models. ECT, the more commonly used technique, due to the rapidity with which full SG tube wall inspection can be performed, is challenged when inspecting ferromagnetic support structure materials in the presence of magnetite sludge and multiple overlapping degradation modes. In this work, an emerging inspection method, pulsed eddy current (PEC), is being investigated to address some of these particular inspection conditions. Time-domain signals were collected by an 8 coil array PEC probe in which ferromagnetic drilled support hole diameter, depth of rectangular tube frets and 2D tube off-centering were varied. Data sets were analyzed with a modified principal components analysis (MPCA) to extract dominant signal features. Multiple linear regression models were applied to MPCA scores to size hole diameter as well as size rectangular outer diameter tube frets. Models were improved through exploratory factor analysis, which was applied to MPCA scores to refine selection for regression models inputs by removing nonessential information.

  20. BDI Class Topological Superconductors and Generating Correlated Spin Currents in Quantum Anomalous Hall insulators

    NASA Astrophysics Data System (ADS)

    He, James; Wu, Jiansheng; Choy, Ting-Pong; Liu, Xiong-Jun; Tanaka, Y.; Law, K. T.

    2014-03-01

    In this work, we show that a one dimensional AIII class topological insulator, which supports fermionic end states, can be turned into a BDI class topological superconductor (TS) through proximity effect. The resulting BDI TS has two topological phases with one or two Majorana end states at each end of the wire respectively. Interestingly, in the phase with two Majorana end states, the BDI TS causes zero-bias conductance dips in tunneling spectroscopy experiments due to destructive interference of Andreev reflection amplitudes caused by the two Majorana end states. More importantly, this BDI TS can induces resonant crossed Andreev reflections in a normal lead/BDI TS/ normal lead junction, in which an electron from one lead is reflected as a hole in the other lead with probability of unity. Moreover, we show that the currents in the two normal leads are perfectly correlated and spin polarized with opposite spin-polarization. Therefore, BDI TS can be used to generate correlated spin currents. We demonstrate that a quantum Anomalous Hall insulator in proximity to a superconductor can be used to realize the proposed BDI TS.

  1. The impact of shearing flows on electroactive biofilm formation, structure, and current generation

    NASA Astrophysics Data System (ADS)

    Jones, A.-Andrew; Buie, Cullen

    2016-11-01

    A special class of bacteria exist that directly produce electricity. First explored in 1911, these electroactive bacteria catalyze hydrocarbons and transport electrons directly to a metallic electron acceptor forming thicker biofilms than other species. Electroactive bacteria biofilms are thicker because they are not limited by transport of oxygen or other terminal electron acceptors. Electroactive bacteria can produce power in fuel cells. Power production is limited in fuel cells by the bacteria's inability to eliminate protons near the insoluble electron acceptor not utilized in the wild. To date, they have not been successfully evolved or engineered to overcome this limit. This limitation may be overcome by enhancing convective mass transport while maintaining substantial biomass within the biofilm. Increasing convective mass transport increases shear stress. A biofilm may respond to increased shear by changing biomass, matrix, or current production. In this study, a rotating disk electrode is used to separate nutrient from physical stress. This phenomenon is investigated using the model electroactive bacterium Geobacter sulfurreducens at nutrient loads comparable to flow-through microbial fuel cells. We determine biofilm structure experimentally by measuring the porosity and calculating the tortuosity from confocal microscope images. Biofilm adaptation for electron transport is quantified using electrical impedance spectroscopy. Our ultimate objective is a framework relating biofilm thickness, porosity, shear stress and current generation for the optimization of bioelectrochemical systems The Alfred P Sloan Foundation MPHD Program.

  2. Inspection of ferromagnetic support structures from within alloy 800 steam generator tubes using pulsed eddy current

    NASA Astrophysics Data System (ADS)

    Buck, Jeremy Andrew

    Nondestructive testing is a critical aspect of component lifetime management. Nuclear steam generator (SG) tubes are the thinnest barrier between irradiated primary heat transport system and the secondary heat transport system, whose components are not rated for large radiation fields. Conventional eddy current testing (ECT) and ultrasonic testing are currently employed for inspecting SG tubes, with the former doing most inspections due to speed and reliability based on an understanding of how flaws affect coil impedance parameters when conductors are subjected to harmonically induced currents. However, when multiple degradation modes are present simultaneously near ferromagnetic materials, such as tube fretting, support structure corrosion, and magnetite fouling, ECT reliability decreases. Pulsed eddy current (PEC), which induces transient eddy currents via square wave excitation, has been considered in this thesis to simultaneously examine SG tube and support structure conditions. An array probe consisting of a central driver, coaxial with the tube, and an array of 8 sensing coils, was used in this thesis to perform laboratory measurements. The probe was delivered from the inner diameter (ID) of the SG tube, where support hole diameter, tube frets, and 2D off-centering were varied. When considering two variables simultaneously, scores obtained from a modified principal components analysis (MPCA) were sufficient for parameter extraction. In the case of hole ID variation with two dimensional tube off-centering (three parameters), multiple linear regression (MLR) of the MPCA scores provided good estimates of parameters. However, once a fourth variable, outer diameter tube frets, was introduced, MLR proved insufficient. Artificial neural networks (ANNs) were investigated in order to perform pattern recognition on the MPCA scores to simultaneously extract the four measurement parameters from the data. All models throughout this thesis were created and validated using

  3. Thyristor-based current-fed drive with direct power control for permanent magnet-assisted synchronous reluctance generator

    NASA Astrophysics Data System (ADS)

    Baek, J.; Kwak, S.-S.; Toliyat, H. A.

    2015-03-01

    This paper proposes a robust and simple direct power control (DPC) of a thyristor-based current-fed drive for generator applications. A current-fed drive and permanent magnet-assisted synchronous reluctance generator (PMa-SynRG) are investigated to deliver 3 kW power using a combustion engine. The current-fed drive utilises a thyristor-based three-phase rectifier to convert generator power to DC-link power and a single-phase current-fed inverter to supply a single-phase inductive load. In addition, a new control algorithm is developed based on DPC for the current-fed drive. The DC-link voltage-based DPC is proposed in order to directly control the output power. The goal of the DPC is to maintain the DC-link voltage at the required output power operating point. The DPC has advantages such as a simple algorithm for constant speed operation. Another feature of the developed current-fed drive is its inherent capability to provide generating action by making the PMa-SynRG operates as a generator, rectifying the phase voltages by means of the three-phase rectifier and feeding the power into the load. These features make the current-fed drive a good candidate for driving any type of synchronous generators including the proposed PMa-SynRG.

  4. Dopamine modulation of transient potassium current evokes phase shifts in a central pattern generator network.

    PubMed

    Harris-Warrick, R M; Coniglio, L M; Barazangi, N; Guckenheimer, J; Gueron, S

    1995-01-01

    Bath application of dopamine modifies the rhythmic motor pattern generated by the 14 neuron pyloric network in the stomatogastric ganglion of the spiny lobster, Panulirus interruptus. Among other effects, dopamine excites many of the pyloric constrictor (PY) neurons to fire at high frequency and phase-advances the timing of their activity in the motor pattern. These responses arise in part from direct actions of dopamine to modulate the intrinsic electrophysiological properties of the PY cells, and can be studied in synaptically isolated neurons. The rate of rebound following a hyperpolarizing prestep and the spike frequency during a subsequent depolarization are both accelerated by dopamine. Based on theoretical simulations, Hartline (1979) suggested that the rate of postinhibitory rebound in stomatogastric neurons could vary with the amount of voltage-sensitive transient potassium current (IA). Consistent with this prediction, we found that dopamine evokes a net conductance decrease in synaptically isolated PY neurons. In voltage clamp, dopamine reduces IA, specifically by reducing the amplitude of the slowly inactivating component of the current and shifting its voltage activation curve in the depolarized direction. 4-Aminopyridine, a selective blocker of IA in stomatogastric neurons, mimics and occludes the effects of dopamine on isolated PY neurons. A conductance-based mathematical model of the PY neuron shows appropriate changes in activity upon quantitative modification of the IA parameters affected by dopamine. These results demonstrate that dopamine excites and phase-advances the PY neurons in the rhythmic pyloric motor pattern at least in part by reducing the transient K+ current, IA.

  5. Early stages of wind wave and drift current generation under non-stationary wind conditions.

    NASA Astrophysics Data System (ADS)

    Robles-Diaz, Lucia; Ocampo-Torres, Francisco J.; Branger, Hubert

    2016-04-01

    Generation and amplification mechanisms of ocean waves are well understood under constant wind speed or limited fetch conditions. Under these situations, the momentum and energy transfers from air to water are also quite well known. However during the wind field evolution over the ocean, we may observe sometime high wind acceleration/deceleration situations (e.g. Mexican Tehuano or Mediterranean Mistral wind systems). The evolution of wave systems under these conditions is not well understood. The purpose of these laboratory experiments is to better understand the early stages of water-waves and surface-drift currents under non-stationary wind conditions and to determine the balance between transfers creating waves and surface currents during non-equilibrium situations. The experiments were conducted in the Institut Pythéas wind-wave facility in Marseille-France. The wave tank is 40 m long, 2.7 m wide and 1 m deep. The air section is 50 m long, 3 m wide and 1.8 m height. We used 11 different resistive wave-gauges located along the tank. The momentum fluxes in the air column were estimated from single and X hot-film anemometer measurements. The sampling frequency for wind velocity and surface displacement measurements was 256 Hz. Water-current measurements were performed with a profiling velocimeter. This device measures the first 3.5 cm of the water column with a frequency rate of 100Hz. During the experiments, the wind intensity was abruptly modified with a constant acceleration and deceleration over time. We observed that wind drag coefficient values for accelerated wind periods are lower than the ones reported in previous studies for constant wind speed (Large and Pond 1981; Ocampo-Torres et al. 2010; Smith 1980; Yelland and Taylor 1996). This is probably because the turbulent boundary layer is not completely developed during the increasing-wind sequence. As it was reported in some theoretical studies (Miles 1957; Phillips 1957; Kahma and Donelan 1988), we

  6. Ceramic ware waste as coarse aggregate for structural concrete production.

    PubMed

    García-González, Julia; Rodríguez-Robles, Desirée; Juan-Valdés, Andrés; Morán-Del Pozo, Julia M; Guerra-Romero, M Ignacio

    2015-01-01

    The manufacture of any kind of product inevitably entails the production of waste. The quantity of waste generated by the ceramic industry, a very important sector in Spain, is between 5% and 8% of the final output and it is therefore necessary to find an effective waste recovery method. The aim of the study reported in the present article was to seek a sustainable means of managing waste from the ceramic industry through the incorporation of this type of waste in the total replacement of conventional aggregate (gravel) used in structural concrete. Having verified that the recycled ceramic aggregates met all the technical requirements imposed by current Spanish legislation, established in the Code on Structural Concrete (EHE-08), then it is prepared a control concrete mix and the recycled concrete mix using 100% recycled ceramic aggregate instead of coarse natural aggregate. The concretes obtained were subjected to the appropriate tests in order to conduct a comparison of their mechanical properties. The results show that the concretes made using ceramic sanitary ware aggregate possessed the same mechanical properties as those made with conventional aggregate. It is therefore possible to conclude that the reuse of recycled ceramic aggregate to produce recycled concrete is a feasible alternative for the sustainable management of this waste.

  7. Numerical analysis of internal solitary wave generation around a Island in Kuroshio Current using MITgcm.

    NASA Astrophysics Data System (ADS)

    Kodaira, Tsubasa; Waseda, Takuji

    2013-04-01

    We have conducted ADCP and CTD measurements from 31/8/2010 to 2/9/2010 at the Miyake Island, located approximately 180 km south of Tokyo. The Kuroshio Current approached the island in this period, and the PALSAR image showed parabolic bright line upstream of the island. This bright line may be a surface signature of large amplitude internal solitary wave. Although our measurements did not explicitly show evidence of the internal solitary wave, critical condition might have been satisfied because of the Kuroshio Current and strong seasonal thermocline. To discover the generation mechanism of the large amplitude internal solitary wave at the Miyake Island, we have conducted non-hydrostatic numerical simulation with the MITgcm. A simple box domain, with open boundaries at all sides, is used. The island is simplified to circular cylinder or Gaussian Bell whose radius is 3km at ocean surface level. The size of the domain is 40kmx40kmx500m for circular cylinder cases and 80kmx80kmx500m for Gaussian bell cases. By looking at our CTD data, we have chosen for initial and boundary conditions a tanh function for vertical temperature profile. Salinity was kept constant for simplicity. Vertical density profile is also described by tanh function because we adopt linear type of equation of state. Vertical velocity profile is constant or linearly changed with depth; the vertical mean speed corresponds to the linear phase speed of the first baroclinic mode obtained by solving the eigen-value problem. With these configurations, we have conducted two series of simulations: shear flow through cylinder and uniform flow going through Gaussian Bell topography. Internal solitary waves were generated in front of the cylinder for the first series of simulations with shear flow. The generated internal waves almost purely consisted of 1st baroclinic component. Their intensities were linearly related with upstream vertical shear strength. As the internal solitary wave became larger, its width

  8. The Next Generation Advanced Video Guidance Sensor: Flight Heritage and Current Development

    NASA Technical Reports Server (NTRS)

    Howard, Richard T.; Bryan, Thomas C.

    2009-01-01

    The Next Generation Advanced Video Guidance Sensor (NGAVGS) is the latest in a line of sensors that have flown four times in the last 10 years. The NGAVGS has been under development for the last two years as a long-range proximity operations and docking sensor for use in an Automated Rendezvous and Docking (AR&D) system. The first autonomous rendezvous and docking in the history of the U.S. Space Program was successfully accomplished by Orbital Express, using the Advanced Video Guidance Sensor (AVGS) as the primary docking sensor. That flight proved that the United States now has a mature and flight proven sensor technology for supporting Crew Exploration Vehicles (CEV) and Commercial Orbital Transport Systems (COTS) Automated Rendezvous and Docking (AR&D). NASA video sensors have worked well in the past: the AVGS used on the Demonstration of Autonomous Rendezvous Technology (DART) mission operated successfully in "spot mode" out to 2 km, and the first generation rendezvous and docking sensor, the Video Guidance Sensor (VGS), was developed and successfully flown on Space Shuttle flights in 1997 and 1998. This paper presents the flight heritage and results of the sensor technology, some hardware trades for the current sensor, and discusses the needs of future vehicles that may rendezvous and dock with the International Space Station (ISS) and other Constellation vehicles. It also discusses approaches for upgrading AVGS to address parts obsolescence, and concepts for minimizing the sensor footprint, weight, and power requirements. In addition, the testing of the various NGAVGS development units will be discussed along with the use of the NGAVGS as a proximity operations and docking sensor.

  9. Experimental and numerical study of a dual configuration for a flapping tidal current generator.

    PubMed

    Kim, Jihoon; Quang Le, Tuyen; Hwan Ko, Jin; Ebenezer Sitorus, Patar; Hartarto Tambunan, Indra; Kang, Taesam

    2015-07-30

    In this study, we conduct experimental and consecutive numerical analyses of a flapping tidal current generator with a mirror-type dual configuration with front-swing and rear-swing flappers. An experimental analysis of a small-scale prototype is conducted in a towing tank, and a numerical analysis is conducted by means of two-dimensional computational fluid dynamics simulations with an in-house code. An experimental study with a controller to determine the target arm angle shows that the resultant arm angle is dependent on the input arm angle, the frequency, and the applied load, while a high pitch is obtained simply with a high input arm angle. Through a parametric analysis conducted while varying these factors, a high applied load and a high input arm angle were found to be advantageous. Moreover, the optimal reduced frequency was found to be 0.125 in terms of the power extraction. In consecutive numerical investigations with the kinematics selected from the experiments, it was found that a rear-swing flapper contributes to the total amount of power more than a front-swing flapper with a distance of two times the chord length and with a 90° phase difference between the two. The high contribution stems from the high power generated by the rear-swing flapper, which mimics the tail fin movement of a dolphin along a flow, compared to a plunge system or a front-swing system, which mimics the tail fin movement of a dolphin against a flow. It is also due to the fact that the shed vorticities of the front-swing flapper slightly affect negatively or even positively the power performance of the rear-swing system at a given distance and phase angle.

  10. Generation of spin polarized currents with coherent trapping in magnetic semiconductors

    NASA Astrophysics Data System (ADS)

    Pereira, Pedro H.; Bezerra, Anibal T.; Farinas, Paulo F.; Maialle, Marcelo Z.; Degani, Marcos H.; Studart, Nelson

    2017-04-01

    A semiconductor heterostructure consisting of two quantum wells, one of them magnetically doped, is proposed for the generation of spin currents by two lasers tuned at the resonances formed between two lowest energy states (1 and 2) and the continuum (3), which are set by design to be in a Λ like configuration. By numerically simulating the proposed structure under the action of the laser fields, we are able to observe the formation of a quasi-dark state near the resonance. The structure’s design has been idealized as to place state 2 in the magnetically doped quantum-well, where a constant magnetic field breaks the electronic spin degeneracy, leading to the giant Zeeman splitting. This ensures that only one of the electronic spins is driven into a dark resonance, thus blocking it from escaping the system. The other spin is free to escape, so that a spin polarized photocurrent is generated. The polarization can be switched by changing the frequency of the controlling laser. Since this kind of trapping is based on quantum interference, the switching times are expected to be fast. In our simulation, we do not simplify the structure down to level modeling, rather we simulate the full structure under time dependent oscillating laser fields and then identify the signatures that indicate a three-level like behavior. We based our search for the structure on real doping parameters found in real materials used in the literature, however the idea relies on the potential profiles studied, and the presence of the giant splitting, regardless of the underlying material that may be used.

  11. Evaluation of machine learning tools for inspection of steam generator tube structures using pulsed eddy current

    NASA Astrophysics Data System (ADS)

    Buck, J. A.; Underhill, P. R.; Morelli, J.; Krause, T. W.

    2017-02-01

    Degradation of nuclear steam generator (SG) tubes and support structures can result in a loss of reactor efficiency. Regular in-service inspection, by conventional eddy current testing (ECT), permits detection of cracks, measurement of wall loss, and identification of other SG tube degradation modes. However, ECT is challenged by overlapping degradation modes such as might occur for SG tube fretting accompanied by tube off-set within a corroding ferromagnetic support structure. Pulsed eddy current (PEC) is an emerging technology examined here for inspection of Alloy-800 SG tubes and associated carbon steel drilled support structures. Support structure hole size was varied to simulate uniform corrosion, while SG tube was off-set relative to hole axis. PEC measurements were performed using a single driver with an 8 pick-up coil configuration in the presence of flat-bottom rectangular frets as an overlapping degradation mode. A modified principal component analysis (MPCA) was performed on the time-voltage data in order to reduce data dimensionality. The MPCA scores were then used to train a support vector machine (SVM) that simultaneously targeted four independent parameters associated with; support structure hole size, tube off-centering in two dimensions and fret depth. The support vector machine was trained, tested, and validated on experimental data. Results were compared with a previously developed artificial neural network (ANN) trained on the same data. Estimates of tube position showed comparable results between the two machine learning tools. However, the ANN produced better estimates of hole inner diameter and fret depth. The better results from ANN analysis was attributed to challenges associated with the SVM when non-constant variance is present in the data.

  12. Degradation of the transconductance of a gate-modulated generation current in nMOSFET

    NASA Astrophysics Data System (ADS)

    Chen, Hai-Feng; Guo, Li-Xin; Du, Hui-Min

    2012-08-01

    The degradation of transconductance (G) of a gate-modulated generation current IGD in a LDD nMOSFET is investigated. The G curve shifts rightward under the single electron-injection-stress (EIS). The trapped electrons located in the gate oxide over the LDD region (QL) makes the effective drain voltage diminish. Accordingly, the G peak in depletion (GMD) and that in weak inversion (GMW) decrease. It is found that ΔGMD and ΔGMW each have a linear relationship with the n-th power of stress time (tn) in a dual-log coordinate: ΔGMD ∝ tn, ΔGMD ∝ tn (n = 0.25). During the alternate stress, the injected holes neutralize QL induced by the previous EIS. This neutralization makes the effective VD restore to the initial value and then the IGD peak recovers completely. Yet the threshold voltage recovery is incomplete due to the trapped electron located over the channel (QC). As a result, GMW only recovers to circa 50% of the initial value after the hole-injection-stress (HIS). Instead, GMD almost recovers. The relevant mechanisms are given in detail.

  13. Insights into molecular therapy of glioma: current challenges and next generation blueprint.

    PubMed

    Rajesh, Y; Pal, Ipsita; Banik, Payel; Chakraborty, Sandipan; Borkar, Sachin A; Dey, Goutam; Mukherjee, Ahona; Mandal, Mahitosh

    2017-03-20

    Glioma accounts for the majority of human brain tumors. With prevailing treatment regimens, the patients have poor survival rates. In spite of current development in mainstream glioma therapy, a cure for glioma appears to be out of reach. The infiltrative nature of glioma and acquired resistance substancially restrict the therapeutic options. Better elucidation of the complicated pathobiology of glioma and proteogenomic characterization might eventually open novel avenues for the design of more sophisticated and effective combination regimens. This could be accomplished by individually tailoring progressive neuroimaging techniques, terminating DNA synthesis with prodrug-activating genes, silencing gliomagenesis genes (gene therapy), targeting miRNA oncogenic activity (miRNA-mRNA interaction), combining Hedgehog-Gli/Akt inhibitors with stem cell therapy, employing tumor lysates as antigen sources for efficient depletion of tumor-specific cancer stem cells by cytotoxic T lymphocytes (dendritic cell vaccination), adoptive transfer of chimeric antigen receptor-modified T cells, and combining immune checkpoint inhibitors with conventional therapeutic modalities. Thus, the present review captures the latest trends associated with the molecular mechanisms involved in glial tumorigenesis as well as the limitations of surgery, radiation and chemotherapy. In this article we also critically discuss the next generation molecular therapeutic strategies and their mechanisms for the successful treatment of glioma.

  14. Plasmoid ejection and secondary current sheet generation from magnetic reconnection in laser-plasma interaction.

    PubMed

    Dong, Quan-Li; Wang, Shou-Jun; Lu, Quan-Ming; Huang, Can; Yuan, Da-Wei; Liu, Xun; Lin, Xiao-Xuan; Li, Yu-Tong; Wei, Hui-Gang; Zhong, Jia-Yong; Shi, Jian-Rong; Jiang, Shao-En; Ding, Yong-Kun; Jiang, Bo-Bin; Du, Kai; He, Xian-Tu; Yu, M Y; Liu, C S; Wang, Shui; Tang, Yong-Jian; Zhu, Jian-Qiang; Zhao, Gang; Sheng, Zheng-Ming; Zhang, Jie

    2012-05-25

    Reconnection of the self-generated magnetic fields in laser-plasma interaction was first investigated experimentally by Nilson et al. [Phys. Rev. Lett. 97, 255001 (2006)] by shining two laser pulses a distance apart on a solid target layer. An elongated current sheet (CS) was observed in the plasma between the two laser spots. In order to more closely model magnetotail reconnection, here two side-by-side thin target layers, instead of a single one, are used. It is found that at one end of the elongated CS a fanlike electron outflow region including three well-collimated electron jets appears. The (>1 MeV) tail of the jet energy distribution exhibits a power-law scaling. The enhanced electron acceleration is attributed to the intense inductive electric field in the narrow electron dominated reconnection region, as well as additional acceleration as they are trapped inside the rapidly moving plasmoid formed in and ejected from the CS. The ejection also induces a secondary CS.

  15. Enhanced optical second-harmonic generation from the current-biased graphene/SiO2/Si(001) structure.

    PubMed

    An, Yong Q; Nelson, Florence; Lee, Ji Ung; Diebold, Alain C

    2013-05-08

    We find that optical second-harmonic generation (SHG) in reflection from a chemical-vapor-deposition graphene monolayer transferred onto a SiO2/Si(001) substrate is enhanced about 3 times by the flow of direct current electric current in graphene. Measurements of rotational-anisotropy SHG revealed that the current-induced SHG from the current-biased graphene/SiO2/Si(001) structure undergoes a phase inversion as the measurement location on graphene is shifted laterally along the current flow direction. The enhancement is due to current-associated charge trapping at the graphene/SiO2 interface, which introduces a vertical electric field across the SiO2/Si interface that produces electric field-induced SHG. The phase inversion is due to the positive-to-negative polarity switch in the current direction of the trapped charges at the current-biased graphene/SiO2 interface.

  16. Detection of Upper Airway Status and Respiratory Events by a Current Generation Positive Airway Pressure Device

    PubMed Central

    Li, Qing Yun; Berry, Richard B.; Goetting, Mark G.; Staley, Bethany; Soto-Calderon, Haideliza; Tsai, Sheila C.; Jasko, Jeffrey G.; Pack, Allan I.; Kuna, Samuel T.

    2015-01-01

    Study Objectives: To compare a positive airway pressure (PAP) device's detection of respiratory events and airway status during device-detected apneas with events scored on simultaneous polysomnography (PSG). Design: Prospective PSGs of patients with sleep apnea using a new-generation PAP device. Settings: Four clinical and academic sleep centers. Patients: Forty-five patients with obstructive sleep apnea (OSA) and complex sleep apnea (Comp SA) performed a PSG on PAP levels adjusted to induce respiratory events. Interventions: None. Measurements and Results: PAP device data identifying the type of respiratory event and whether the airway during a device-detected apnea was open or obstructed were compared to time-synced, manually scored respiratory events on simultaneous PSG recording. Intraclass correlation coefficients between device-detected and PSG scored events were 0.854 for apnea-hypopnea index (AHI), 0.783 for apnea index, 0.252 for hypopnea index, and 0.098 for respiratory event-related arousals index. At a device AHI (AHIFlow) of 10 events/h, area under the receiver operating characteristic curve was 0.98, with sensitivity 0.92 and specificity 0.84. AHIFlow tended to overestimate AHI on PSG at values less than 10 events/h. The device detected that the airway was obstructed in 87.4% of manually scored obstructive apneas. Of the device-detected apneas with clear airway, a minority (15.8%) were manually scored as obstructive apneas. Conclusions: A device-detected apnea-hypopnea index (AHIFlow) < 10 events/h on a positive airway pressure device is strong evidence of good treatment efficacy. Device-detected airway status agrees closely with the presumed airway status during polysomnography scored events, but should not be equated with a specific type of respiratory event. Citation: Li QY, Berry RB, Goetting MG, Staley B, Soto-Calderon H, Tsai SC, Jasko JG, Pack AI, Kuna ST. Detection of upper airway status and respiratory events by a current generation positive

  17. Strategies for the Use of Tidal Stream Currents for Power Generation

    NASA Astrophysics Data System (ADS)

    Orhan, Kadir; Mayerle, Roberto

    2015-04-01

    Indonesia is one of the priority countries in Southeast Asia for the development of ocean renewable energy facilities and The National Energy Council intends to increase the role of ocean energy significantly in the energy mix for 2010-2050. To this end, the joint German-Indonesian project "Ocean Renewable Energy ORE-12" aims at the identification of marine environments in the Indonesian Archipelago, which are suitable for the efficient generation of electric power by converter facilities. This study, within the ORE-12 project, is focused on the tidal stream currents on the straits between the Indian Ocean and Flores Sea to estimate the energy potentials and to develop strategies for producing renewable energy. FLOW module of Delft3D has been used to run hydrodynamic models for site assessment and design development. In site assessment phase, 2D models have been operated for a-month long periods and with a resolution of 500 m. Later on, in design development phase, detailed 3D models have been developed and operated for three-month long periods and with a resolution of 50 m. Bathymetric data for models have been obtained from the GEBCO_08 Grid and wind data from the Global Forecast System of NOAA's National Climatic Data Center. To set the boundary conditions of models, tidal forcing with 11 harmonic constituents was supplied from TPXO Indian Ocean Atlas (1/12° regional model) and data from HYCOM+NCODA Global 1/12° Analysis have been used to determine salinity and temperature on open boundaries. After the field survey is complete, water level time-series supplied from a tidal gauge located in the domain of interest (8° 20΄ 9.7" S, 122° 54΄ 51.9" E) have been used to verify the models and then energy potentials of the straits have been estimated. As a next step, correspondence between model outputs and measurements taken by the radar system of TerraSAR-X satellite (DLR) will be analysed. Also for the assessment of environmental impacts caused by tidal stream

  18. Plasmas generated in bubbles immersed in liquids: direct current streamers versus microwave plasma

    NASA Astrophysics Data System (ADS)

    Levko, Dmitry; Sharma, Ashish; Raja, Laxminarayan L.

    2016-07-01

    Two approaches to generate non-equilibrium atmospheric-pressure plasma in bubbles immersed in liquids are compared using high-fidelity 2D fluid simulations. In the first approach, corona/streamer like plasma is generated using high-voltage negative and positive pulses applied between two electrodes (pin-to-plane geometry) immersed in liquid. In the second, the plasma is generated using a remote microwave source (frequency 2.45 GHz). We find that the microwave approach requires less energy, while generating a denser, more chemically reactive and more uniform plasma within the bubble volume, as compared to the plasma generated using high-voltage pulsing.

  19. Second-generation antipsychotics in the treatment of major depressive disorder: current evidence.

    PubMed

    Han, Changsu; Wang, Sheng-Min; Kato, Masaki; Lee, Soo-Jung; Patkar, Ashwin A; Masand, Prakash S; Pae, Chi-Un

    2013-07-01

    Major depressive disorder (MDD) is a chronic and recurrent mental condition leading to huge impacts on direct and indirect personal and public medical costs. To overcome such a serious mental disorder, we currently have a number of different classes of antidepressants, such as selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, noradrenergic and specific serotonin receptor antagonists, dopamine and norepinephrine reuptake inhibitors, along with newly introduced antidepressants (e.g., vilazodone and agomelatine). However, a number of well-controlled clinical trials, meta-analyses and practical clinical studies have found that only a third of such MDD patients remit following adequate antidepressant treatment, while most MDD patients suffer from significant core depressive or residual symptoms during their clinical course. There have been some treatment approaches to overcome such a shortage of antidepressant efficacy, such as augmentation of psychotropics other than antidepressants, switching to a different antidepressant and combinations of different antidepressants. Among these different second treatment options, augmentation treatment has some favorable points compared with the combination and switching option (e.g., maintaining previous antidepressant partial response, synergistic effect between different pharmacological profile and no need to wash out previous antidepressants). Recently, second-generation antipsychotics (SGAs), olanzapine plus fluoxetine, quetiapine extended release and aripiprazole have clearly demonstrated efficacy in the treatment of MDD patients through a number of small-scale, open-label studies or randomized, placebo-controlled clinical trials. Eventually, in November 2007, aripiprazole was the first approved by the US FDA as an adjunctive treatment to antidepressants for treating MDD, followed by the approval of quetiapine and olanzapine plus fluoxetine at 2009. This comprehensive review provides an

  20. A pulsed-power generator merging inductive voltage and current adders and its switch trigger application example

    NASA Astrophysics Data System (ADS)

    Li, Lee; Yafeng, Ge; Heqin, Zhong; Bin, Yu; Longjun, Xie

    2013-07-01

    A pulsed-power generator using inductive adder technology is proposed for the case of a discharge gap. The merit of this generator is to merge the pulsed-voltage and pulsed-current adders via the dual secondary windings with special circuit. For the nonlinear impedance in any discharge gap, the standalone voltage-pulse and current-pulse can be outputted successively by this generator. The proposed generator is especially useful for the common resolution of implementing pulse discharge at less cost. As an application example, a compact trigger prototype was developed to compatibly use in the gas-insulated and vacuum switches. Experiments achieved good results that the triggered switches showed stable performance and long life. If the basic circuit of this proposed generator is regarded as a pulsed-generating unit, a certain number of such units connected in parallel can be expected to form a general device with generating greater breakdown-voltage and sustained-current pulses for discharge gaps.

  1. A pulsed-power generator merging inductive voltage and current adders and its switch trigger application example.

    PubMed

    Li, Lee; Yafeng, Ge; Heqin, Zhong; Bin, Yu; Longjun, Xie

    2013-07-01

    A pulsed-power generator using inductive adder technology is proposed for the case of a discharge gap. The merit of this generator is to merge the pulsed-voltage and pulsed-current adders via the dual secondary windings with special circuit. For the nonlinear impedance in any discharge gap, the standalone voltage-pulse and current-pulse can be outputted successively by this generator. The proposed generator is especially useful for the common resolution of implementing pulse discharge at less cost. As an application example, a compact trigger prototype was developed to compatibly use in the gas-insulated and vacuum switches. Experiments achieved good results that the triggered switches showed stable performance and long life. If the basic circuit of this proposed generator is regarded as a pulsed-generating unit, a certain number of such units connected in parallel can be expected to form a general device with generating greater breakdown-voltage and sustained-current pulses for discharge gaps.

  2. Surface spin-polarized currents generated in topological insulators by circularly polarized synchrotron radiation and their photoelectron spectroscopy indication

    NASA Astrophysics Data System (ADS)

    Shikin, A. M.; Klimovskikh, I. I.; Filyanina, M. V.; Rybkina, A. A.; Pudikov, D. A.; Kokh, K. A.; Tereshchenko, O. E.

    2016-08-01

    A new method for generating spin-polarized currents in topological insulators has been proposed and investigated. The method is associated with the spin-dependent asymmetry of the generation of holes at the Fermi level for branches of topological surface states with the opposite spin orientation under the circularly polarized synchrotron radiation. The result of the generation of holes is the formation of compensating spin-polarized currents, the value of which is determined by the concentration of the generated holes and depends on the specific features of the electronic and spin structures of the system. The indicator of the formed spin-polarized current can be a shift of the Fermi edge in the photoelectron spectra upon photoexcitation by synchrotron radiation with the opposite circular polarization. The topological insulators with different stoichiometric compositions (Bi1.5Sb0.5Te1.8Se1.2 and PbBi2Se2Te2) have been investigated. It has been found that there is a correlation in the shifts and generated spin-polarized currents with the specific features of the electronic spin structure. Investigations of the graphene/Pt(111) system have demonstrated the possibility of using this method for other systems with a spin-polarized electronic structure.

  3. Functional role of follicular cells in the generation of osmolarity-dependent Cl- currents in Xenopus follicles.

    PubMed Central

    Arellano, R O; Miledi, R

    1995-01-01

    1. Osmolarity-dependent (osmo-dependent) ionic currents from follicle-enclosed Xenopus oocytes (follicles) were studied using the two-microelectrode voltage-clamp technique, combined with intra-oocyte pressure injection of sucrose or polyethylene glycols (PEGs). 2. Intra-oocyte injections of sucrose or PEG (3-25 nmol) generated inward membrane currents (follicles held at -60 mV) associated with an increase in membrane conductance. These currents were carried mainly by chloride ions (ICl(osm)), and were strongly attenuated by increasing the tonicity of the external medium, or by external application of La3+ (0.1-1 mM). 3. The ability to generate ICl(osm) depended on the molecular weight of the injected PEG. Injections of PEG 200 or 300 generated ICl(osm) in 95% of the follicles tested, PEG 600 generated comparable currents in only 20% of the follicles, while similar injections of PEG 1000 did not elicit ICl(osm). 4. Octanol (1-1.5 mM), a gap junction channel blocker, reversibly inhibited 50-90% of the ICl(osm) generated by injections of sucrose or PEG 300. Moreover, sucrose or PEG injections did not elicit ICl(osm) in defolliculated oocytes. 5. It is concluded that an increase in the internal osmolarity of the follicular cells activates a mechanism, probably involving cellular swelling, which leads to the opening of ICl(osm) channels most probably located in the follicular cell membrane. PMID:8568675

  4. In vitro generation of three-dimensional substrate-adherent embryonic stem cell-derived neural aggregates for application in animal models of neurological disorders.

    PubMed

    Hargus, Gunnar; Cui, Yi-Fang; Dihné, Marcel; Bernreuther, Christian; Schachner, Melitta

    2012-05-01

    In vitro-differentiated embryonic stem (ES) cells comprise a useful source for cell replacement therapy, but the efficiency and safety of a translational approach are highly dependent on optimized protocols for directed differentiation of ES cells into the desired cell types in vitro. Furthermore, the transplantation of three-dimensional ES cell-derived structures instead of a single-cell suspension may improve graft survival and function by providing a beneficial microenvironment for implanted cells. To this end, we have developed a new method to efficiently differentiate mouse ES cells into neural aggregates that consist predominantly (>90%) of postmitotic neurons, neural progenitor cells, and radial glia-like cells. When transplanted into the excitotoxically lesioned striatum of adult mice, these substrate-adherent embryonic stem cell-derived neural aggregates (SENAs) showed significant advantages over transplanted single-cell suspensions of ES cell-derived neural cells, including improved survival of GABAergic neurons, increased cell migration, and significantly decreased risk of teratoma formation. Furthermore, SENAs mediated functional improvement after transplantation into animal models of Parkinson's disease and spinal cord injury. This unit describes in detail how SENAs are efficiently derived from mouse ES cells in vitro and how SENAs are isolated for transplantation. Furthermore, methods are presented for successful implantation of SENAs into animal models of Huntington's disease, Parkinson's disease, and spinal cord injury to study the effects of stem cell-derived neural aggregates in a disease context in vivo.

  5. A new approach to study the effect of generation rate on drain-source current of bilayer graphene transistors

    NASA Astrophysics Data System (ADS)

    Ahmad, H.; Ghadiry, M.; AbdManaf, A.

    2016-10-01

    This paper presents a new approach to study the effect of impact ionization on the current of bilayer graphene field effect transistors. Analytical models for surface potential and current together with a Monte Carlo approach which include the edge effect scattering are used to calculate the current and generation rate in bilayer graphene transistors due to ionization. FlexPDE simulation is also employed for verification of surface potential modeling. Using the approach, the profile of generation rate, surface potential and current are plotted with respect to several structural parameters. We have shown that ignoring this effect in the modeling will result in an error of up to 10 % for a typical 30 nm bilayer graphene field effect transistor. As a result, we conclude that any analytical study ignoring the ionization is incomplete for bilayer graphene field effect transistors. The model presented here can be applied in optimization of photo detectors based on graphene.

  6. Analyses of current-generating mechanisms of Shewanella loihica PV-4 and Shewanella oneidensis MR-1 in microbial fuel cells.

    PubMed

    Newton, Gregory J; Mori, Shigeki; Nakamura, Ryuhei; Hashimoto, Kazuhito; Watanabe, Kazuya

    2009-12-01

    Although members of the genus Shewanella have common features (e.g., the presence of decaheme c-type cytochromes [c-cyts]), they are widely variable in genetic and physiological features. The present study compared the current-generating ability of S. loihica PV-4 in microbial fuel cells (MFCs) with that of well-characterized S. oneidensis MR-1 and examined the roles of c-cyts in extracellular electron transfer. We found that strains PV-4 and MR-1 exhibited notable differences in current-generating mechanisms. While the MR-1 MFCs maintained a constant current density over time, the PV-4 MFCs continued to increase in current density and finally surpassed the MR-1 MFCs. Coulombic efficiencies reached 26% in the PV-4 MFC but 16% in the MR-1 MFCs. Although both organisms produced quinone-like compounds, anode exchange experiments showed that anode-attached cells of PV-4 produced sevenfold more current than planktonic cells in the same chamber, while planktonic cells of MR-1 produced twice the current of the anode-attached cells. Examination of the genome sequence indicated that PV-4 has more c-cyt genes in the metal reductase-containing locus than MR-1. Mutational analysis revealed that PV-4 relied predominantly on a homologue of the decaheme c-cyt MtrC in MR-1 for current generation, even though it also possesses two homologues of the decaheme c-cyt OmcA in MR-1. These results suggest that current generation in a PV-4 MFC is in large part accomplished by anode-attached cells, in which the MtrC homologue constitutes the main path of electrons toward the anode.

  7. Impact of cercal air currents on singing motor pattern generation in the cricket (Gryllus bimaculatus DeGeer).

    PubMed

    Jacob, Pedro F; Hedwig, Berthold

    2015-11-01

    The cercal system of crickets detects low-frequency air currents produced by approaching predators and self-generated air currents during singing, which may provide sensory feedback to the singing motor network. We analyzed the effect of cercal stimulation on singing motor pattern generation to reveal the response of a singing interneuron to predator-like signals and to elucidate the possible role of self-generated air currents during singing. In fictive singing males, we recorded an interneuron of the singing network while applying air currents to the cerci; additionally, we analyzed the effect of abolishing the cercal system in freely singing males. In fictively singing crickets, the effect of short air stimuli is either to terminate prematurely or to lengthen the interchirp interval, depending on their phase in the chirp cycle. Within our stimulation paradigm, air stimuli of different velocities and durations always elicited an inhibitory postsynaptic potential in the singing interneuron. Current injection in the singing interneuron elicited singing motor activity, even during the air current-evoked inhibitory input from the cercal pathway. The disruptive effects of air stimuli on the fictive singing pattern and the inhibitory response of the singing interneuron point toward the cercal system being involved in initiating avoidance responses in singing crickets, according to the established role of cerci in a predator escape pathway. After abolishing the activity of the cercal system, the timing of natural singing activity was not significantly altered. Our study provides no evidence that self-generated cercal sensory activity has a feedback function for singing motor pattern generation.

  8. Impact of cercal air currents on singing motor pattern generation in the cricket (Gryllus bimaculatus DeGeer)

    PubMed Central

    2015-01-01

    The cercal system of crickets detects low-frequency air currents produced by approaching predators and self-generated air currents during singing, which may provide sensory feedback to the singing motor network. We analyzed the effect of cercal stimulation on singing motor pattern generation to reveal the response of a singing interneuron to predator-like signals and to elucidate the possible role of self-generated air currents during singing. In fictive singing males, we recorded an interneuron of the singing network while applying air currents to the cerci; additionally, we analyzed the effect of abolishing the cercal system in freely singing males. In fictively singing crickets, the effect of short air stimuli is either to terminate prematurely or to lengthen the interchirp interval, depending on their phase in the chirp cycle. Within our stimulation paradigm, air stimuli of different velocities and durations always elicited an inhibitory postsynaptic potential in the singing interneuron. Current injection in the singing interneuron elicited singing motor activity, even during the air current-evoked inhibitory input from the cercal pathway. The disruptive effects of air stimuli on the fictive singing pattern and the inhibitory response of the singing interneuron point toward the cercal system being involved in initiating avoidance responses in singing crickets, according to the established role of cerci in a predator escape pathway. After abolishing the activity of the cercal system, the timing of natural singing activity was not significantly altered. Our study provides no evidence that self-generated cercal sensory activity has a feedback function for singing motor pattern generation. PMID:26334014

  9. Direct electric current treatment under physiologic saline conditions kills Staphylococcus epidermidis biofilms via electrolytic generation of hypochlorous acid.

    PubMed

    Sandvik, Elizabeth L; McLeod, Bruce R; Parker, Albert E; Stewart, Philip S

    2013-01-01

    The purpose of this study was to investigate the mechanism by which a direct electrical current reduced the viability of Staphylococcus epidermidis biofilms in conjunction with ciprofloxacin at physiologic saline conditions meant to approximate those in an infected artificial joint. Biofilms grown in CDC biofilm reactors were exposed to current for 24 hours in 1/10(th) strength tryptic soy broth containing 9 g/L total NaCl. Dose-dependent log reductions up to 6.7 log(10) CFU/cm(2) were observed with the application of direct current at all four levels (0.7 to 1.8 mA/cm(2)) both in the presence and absence of ciprofloxacin. There were no significant differences in log reductions for wells with ciprofloxacin compared to those without at the same current levels. When current exposures were repeated without biofilm or organics in the medium, significant generation of free chlorine was measured. Free chlorine doses equivalent to the 24 hour endpoint concentration for each current level were shown to mimic killing achieved by current application. Current exposure (1.8 mA/cm(2)) in medium lacking chloride and amended with sulfate, nitrate, or phosphate as alternative electrolytes produced diminished kills of 3, 2, and 0 log reduction, respectively. Direct current also killed Pseudomonas aeruginosa biofilms when NaCl was present. Together these results indicate that electrolysis reactions generating hypochlorous acid from chloride are likely a main contributor to the efficacy of direct current application. A physiologically relevant NaCl concentration is thus a critical parameter in experimental design if direct current is to be investigated for in vivo medical applications.

  10. Direct Electric Current Treatment under Physiologic Saline Conditions Kills Staphylococcus epidermidis Biofilms via Electrolytic Generation of Hypochlorous Acid

    PubMed Central

    Sandvik, Elizabeth L.; McLeod, Bruce R.; Parker, Albert E.; Stewart, Philip S.

    2013-01-01

    The purpose of this study was to investigate the mechanism by which a direct electrical current reduced the viability of Staphylococcus epidermidis biofilms in conjunction with ciprofloxacin at physiologic saline conditions meant to approximate those in an infected artificial joint. Biofilms grown in CDC biofilm reactors were exposed to current for 24 hours in 1/10th strength tryptic soy broth containing 9 g/L total NaCl. Dose-dependent log reductions up to 6.7 log10 CFU/cm2 were observed with the application of direct current at all four levels (0.7 to 1.8 mA/cm2) both in the presence and absence of ciprofloxacin. There were no significant differences in log reductions for wells with ciprofloxacin compared to those without at the same current levels. When current exposures were repeated without biofilm or organics in the medium, significant generation of free chlorine was measured. Free chlorine doses equivalent to the 24 hour endpoint concentration for each current level were shown to mimic killing achieved by current application. Current exposure (1.8 mA/cm2) in medium lacking chloride and amended with sulfate, nitrate, or phosphate as alternative electrolytes produced diminished kills of 3, 2, and 0 log reduction, respectively. Direct current also killed Pseudomonas aeruginosa biofilms when NaCl was present. Together these results indicate that electrolysis reactions generating hypochlorous acid from chloride are likely a main contributor to the efficacy of direct current application. A physiologically relevant NaCl concentration is thus a critical parameter in experimental design if direct current is to be investigated for in vivo medical applications. PMID:23390518

  11. Unconventional spin Hall effect and axial current generation in a Dirac semimetal

    NASA Astrophysics Data System (ADS)

    Okuma, Nobuyuki; Ogata, Masao

    2016-04-01

    We investigate electrical transport in a three-dimensional massless Dirac fermion model that describes a Dirac semimetal state realized in topological materials. We derive a set of interdependent diffusion equations with eight local degrees of freedom, including the electric charge density and the spin density, that respond to an external electric field. By solving the diffusion equations for a system with a boundary, we demonstrate that a spin Hall effect with spin accumulation occurs even though the conventional spin current operator is zero. The Noether current associated with chiral symmetry, known as the axial current, is also discussed. We demonstrate that the axial current flows near the boundary and that it is perpendicular to the electric current.

  12. Disposition of Radioisotope Thermoelectric Generators Currently Located at the Oak Ridge National Laboratory - 12232

    SciTech Connect

    Glenn, J.; Patterson, J.; DeRoos, K.; Patterson, J.E.; Mitchell, K.G.

    2012-07-01

    Under the American Recovery and Reinvestment Act (ARRA), the U.S. Department of Energy (DOE) awarded SEC Federal Services Corporation (SEC) a 34-building demolition and disposal (D and D) project at the Oak Ridge National Laboratory (ORNL) that included the disposition of six Strontium (Sr-90) powered Radioisotope Thermoelectric Generators (RTGs) stored outside of ORNL Building 3517. Disposition of the RTGs is very complex both in terms of complying with disposal facility waste acceptance criteria (WAC) and U.S. Department of Transportation (DOT) requirements for packaging and transportation in commerce. Two of the RTGs contain elemental mercury which requires them to be Land Disposal Restrictions (LDR) compliant prior to disposal. In addition, all of the RTGs exceed the Class C waste concentration limits under Nuclear Regulatory Commission (NRC) Waste Classification Guidelines. In order to meet the LDR requirements and Nevada National Security Site (NNSS) WAC, a site specific treatability variance for mercury was submitted to the U.S. Environmental Protection Agency (EPA) to allow macro-encapsulation to be an acceptable treatment standard for elemental mercury. By identifying and confirming the design configuration of the mercury containing RTGs, the SEC team proved that the current configuration met the macro-encapsulation standard of 40 Code of Federal Regulations (CFR) 268.45. The SEC Team also worked with NNSS to demonstrate that all radioisotope considerations are compliant with the NNSS low-level waste (LLW) disposal facility performance assessment and WAC. Lastly, the SEC team determined that the GE2000 Type B cask met the necessary size, weight, and thermal loading requirements for five of the six RTGs. The sixth RTG (BUP-500) required a one-time DOT shipment exemption request due to the RTG's large size. The DOT exemption justification for the BUP-500 relies on the inherent robust construction and material make-up of the BUP- 500 RTG. DOE-ORO, SEC, and

  13. Single cell wound generates electric current circuit and cell membrane potential variations that requires calcium influx.

    PubMed

    Luxardi, Guillaume; Reid, Brian; Maillard, Pauline; Zhao, Min

    2014-07-24

    Breaching of the cell membrane is one of the earliest and most common causes of cell injury, tissue damage, and disease. If the compromise in cell membrane is not repaired quickly, irreversible cell damage, cell death and defective organ functions will result. It is therefore fundamentally important to efficiently repair damage to the cell membrane. While the molecular aspects of single cell wound healing are starting to be deciphered, its bio-physical counterpart has been poorly investigated. Using Xenopus laevis oocytes as a model for single cell wound healing, we describe the temporal and spatial dynamics of the wound electric current circuitry and the temporal dynamics of cell membrane potential variation. In addition, we show the role of calcium influx in controlling electric current circuitry and cell membrane potential variations. (i) Upon wounding a single cell: an inward electric current appears at the wound center while an outward electric current is observed at its sides, illustrating the wound electric current circuitry; the cell membrane is depolarized; calcium flows into the cell. (ii) During cell membrane re-sealing: the wound center current density is maintained for a few minutes before decreasing; the cell membrane gradually re-polarizes; calcium flow into the cell drops. (iii) In conclusion, calcium influx is required for the formation and maintenance of the wound electric current circuitry, for cell membrane re-polarization and for wound healing.

  14. Absolute negative conductivity and spontaneous current generation in semiconductor superlattices with hot electrons

    PubMed

    Cannon; Kusmartsev; Alekseev; Campbell

    2000-08-07

    We study transport through a semiconductor superlattice with an electric field parallel to and a magnetic field perpendicular to the growth axis. Using a semiclassical balance equation model with elastic and inelastic scattering, we find that (1) the current-voltage characteristic becomes multistable in a large magnetic field and (2) "hot" electrons display novel features in their current-voltage characteristics, including absolute negative conductivity and a spontaneous dc current at zero bias. We discuss experimental situations providing hot electrons to observe these effects.

  15. Effect of eddy current damping on phononic band gaps generated by locally resonant periodic structures

    NASA Astrophysics Data System (ADS)

    Ozkaya, Efe; Yilmaz, Cetin

    2017-02-01

    The effect of eddy current damping on a novel locally resonant periodic structure is investigated. The frequency response characteristics are obtained by using a lumped parameter and a finite element model. In order to obtain wide band gaps at low frequencies, the periodic structure is optimized according to certain constraints, such as mass distribution in the unit cell, lower limit of the band gap, stiffness between the components in the unit cell, the size of magnets used for eddy current damping, and the number of unit cells in the periodic structure. Then, the locally resonant periodic structure with eddy current damping is manufactured and its experimental frequency response is obtained. The frequency response results obtained analytically, numerically and experimentally match quite well. The inclusion of eddy current damping to the periodic structure decreases amplitudes of resonance peaks without disturbing stop band width.

  16. Quantitative void fraction measurement with an eddy current flowmeter for generation IV Sodium cooled Fast Reactor

    SciTech Connect

    Kumar, M.; Tordjeman, Ph.; Bergez, W.; Cavaro, M.; Paumel, K.; Jeannot, J.P.

    2015-07-01

    This study was carried out to understand the response of an eddy current type flowmeter in two phase liquid-metal flow. We use the technique of ellipse fit and correlate the fluctuations in the angle of inclination of this ellipse with the void fraction. The effects of physical parameters such as coil excitation frequency and flow velocity have been studied. The results show the possibility of using an eddy current flowmeter as a gas detector for large void fractions. (authors)

  17. Quantitative void fraction detection with an eddy current flowmeter for generation IV Sodium cooled Fast Reactor

    SciTech Connect

    Kumar, M.; Tordjeman, Ph.; Bergez, W.; Cavaro, M.; Paumel, K.; Jeannot, J. P.

    2015-07-01

    This study was carried out to understand the response of an eddy current type flowmeter in two phase liquid-metal flow. We use the technique of ellipse fit and correlate the fluctuations in the angle of inclination of this ellipse with the void fraction. The effects of physical parameters such as coil excitation frequency and flow velocity have been studied. The results show the possibility of using an eddy current flowmeter as a gas detector for large void fractions. (authors)

  18. High-Current-Density Thermionic Cathodes and the Generation of High-Voltage Electron Beams

    DTIC Science & Technology

    1989-04-30

    pulsing results, up to 140 kV was applied across this length of boron nitride without surface flashover . The anode face plate is made of stainless steel...current distribution over the cathode surface and correlation with thermionic-emission theory , 3. sign and testing of an electron-gun diode with an...aperture across the cathode surface by moving the anode transversely. The arrangement is shown in Figure 5. The sampled cathode current (0.16 percent of

  19. Improving Aerosol and Visibility Forecasting Capabilities Using Current and Future Generations of Satellite Observations

    DTIC Science & Technology

    2012-09-30

    framework for considering current and future satellite aerosol products. 2 . Develop forward models to enable a radiance assimilation capability by: 1...improving forecast performance over cloudy regions using the Ozone Monitoring Instrument (OMI) Aerosol Index; and 2 ) preparing for the post-MODIS... 2 . REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Improving Aerosol and Visibility Forecasting Capabilities Using Current and

  20. Participation of a persistent sodium current and calcium-activated nonspecific cationic current to burst generation in trigeminal principal sensory neurons

    PubMed Central

    Tsuruyama, Kentaro; Hsiao, Chie-Fang

    2013-01-01

    The properties of neurons participating in masticatory rhythmogenesis are not clearly understood. Neurons within the dorsal trigeminal principal sensory nucleus (dPrV) are potential candidates as components of the masticatory central pattern generator (CPG). The present study examines in detail the ionic mechanisms controlling burst generation in dPrV neurons in rat (postnatal day 8–12) brain stem slices using whole cell and perforated patch-clamp methods. Nominal extracellular Ca2+ concentration transformed tonic discharge in response to a maintained step pulse of current into rhythmical bursting in 38% of nonbursting neurons. This change in discharge mode was suppressed by riluzole, a persistent Na+ current (INaP) antagonist. Veratridine, which suppresses the Na+ channel inactivation mechanism, induced rhythmical bursting in nonbursting neurons in normal artificial cerebrospinal fluid, suggesting that INaP contributes to burst generation. Nominal extracellular Ca2+ exposed a prominent afterdepolarizing potential (ADP) following a single spike induced by a 3-ms current pulse, which was suppressed, but not completely blocked, by riluzole. Application of BAPTA, a Ca2+ chelator, intracellularly, or flufenamic acid, a Ca2+-activated nonspecific cationic channel (ICAN) antagonist, extracellularly to the bath, suppressed rhythmical bursting and the postspike ADP. Application of drugs to alter Ca2+ release from endoplasmic reticulum also suppressed bursting. Finally, voltage-clamp methods demonstrated that nominal Ca2+ facilitated INaP and induced ICAN. These data demonstrate for the first time that the previously observed induction in dPrV neurons of rhythmical bursting in nominal Ca2+ is mediated by enhancement of INaP and onset of ICAN, which are dependent on intracellular Ca2+. PMID:23883859

  1. Locally Generated Title Derivative Indexing in Academic and Public Libraries: A Survey of Current Practices.

    ERIC Educational Resources Information Center

    Schwarz, Philip J.

    A library survey to examine and analyze locally generated title derivative keyword indexing in academic and public libraries and its findings are presented. The project was organized in two phases. The first attempted to identify successful title derivative indexing programs through a literature review, correspondence with individuals known to be…

  2. Historical and Current U.S. Strategies for Boosting Distributed Generation

    SciTech Connect

    Lowder, Travis; Schwabe, Paul; Zhou, Ella; Arent, Douglas J.

    2015-10-29

    This report seeks to introduce a variety of top-down and bottom-up practices that, in concert with the macro-environment of cost-reduction globally and early adoption in Europe, helped boost the distributed generation photovoltaic market in the United States. These experiences may serve as a reference in China's quest to promote distributed renewable energy.

  3. Microstructure dependence of the c-axis critical current density in second generation YBCO tapes

    SciTech Connect

    Jia, Y. Welp, U. Crabtree, G.W.; Kwok, W.K.; Malozemoff, A.P.; Rupich, M.W.; Fleshler, S.; Clem, J.R.

    2011-10-31

    C-axis current flow in high temperature superconductor (HTS) tape-shaped wires arises in configurations where the local wire axis is not perpendicular to the local magnetic field, such as in power cables with helically wound HTS tapes. The c-axis critical current density J{sub c}{sup c} has been recently found to be orders of magnitude lower than the ab-plane critical current density J{sub c}{sup ab}. Here we report on J{sub c}{sup c} (77 K, sf) values of various YBa{sub 2}Cu{sub 3}O{sub 7}-based (YBCO) tapes with different microstructures. Our results show that the value of J{sub c}{sup c} (77 K, sf) decreases significantly with increasing concentration of ab-plane stacking faults in YBCO thin films and that the critical current anisotropy {gamma} = J{sub c}{sup ab}/J{sub c}{sup c} can reach values as high as 2070, implying that in the highest-anisotropy tape, {approx}20% of the tape width carries c-axis current in a helically wound power cable.

  4. Microstructure dependence of the c-axis critical current density in second-generation YBCO tapes.

    SciTech Connect

    Jia, Y.; Welp, U.; Crabtree, G. W.; Kwok, W. K.; Malozemoff, A. P.; Rupich, M. W.; Fleshler, S.; Clem, J. R.

    2011-10-01

    C-axis current flow in high temperature superconductor (HTS) tape-shaped wires arises in configurations where the local wire axis is not perpendicular to the local magnetic field, such as in power cables with helically wound HTS tapes. The c-axis critical current density J{sub c}{sup c} has been recently found to be orders of magnitude lower than the ab-plane critical current density J{sub c}{sup ab}. Here we report on J{sub c}{sup c} (77 K, sf) values of various YBa{sub 2}Cu{sub 3}O{sub 7}-based (YBCO) tapes with different microstructures. Our results show that the value of J{sub c}{sup c} (77 K, sf) decreases significantly with increasing concentration of ab-plane stacking faults in YBCO thin films and that the critical current anisotropy {gamma} = J{sub c}{sup ab}/J{sub c}{sup c} can reach values as high as 2070, implying that in the highest-anisotropy tape, {approx}20% of the tape width carries c-axis current in a helically wound power cable.

  5. Specific characteristics of negative corona currents generated in short point-plane gap

    NASA Astrophysics Data System (ADS)

    Li, Zhen; Zhang, Bo; He, Jinliang

    2013-09-01

    The Trichel pulse is a typical kind of negative corona current observed in electronegative gases with a highly regular form. The characteristics of the Trichel pulse, such as the repetition frequency, the amplitude of each pulse, and the mean current, are dependent on different discharge conditions. Quite many scholars have studied the mean current and the current-voltage characteristic of Trichel pulses, yet the specific characteristics of the pulses have barely been investigated. In this paper, a series of experiments were carried out in a short point-to-plane discharge gap to investigate the detailed characteristics of Trichel pulses. After numerical fitting of the experiment results was performed, a new set of empirical formulas were derived to predict the specific characteristics of the negative corona current under different conditions. Different from existing literature, this paper uses as variables the average electric field intensity and the corona inception field intensity which is independent of the gap spacing in the empirical formulas. In the experiments, an inverse correlation between amplitude and repetition frequency of the pulses was observed. Based on the investigation of the remaining space charge in the discharge gap, this correlation is theoretically proved to be caused by the influence of space charges.

  6. Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.

    PubMed

    Tenke, Craig E; Kayser, Jürgen

    2012-12-01

    The topographic ambiguity and reference-dependency that has plagued EEG/ERP research throughout its history are largely attributable to volume conduction, which may be concisely described by a vector form of Ohm's Law. This biophysical relationship is common to popular algorithms that infer neuronal generators via inverse solutions. It may be further simplified as Poisson's source equation, which identifies underlying current generators from estimates of the second spatial derivative of the field potential (Laplacian transformation). Intracranial current source density (CSD) studies have dissected the "cortical dipole" into intracortical sources and sinks, corresponding to physiologically-meaningful patterns of neuronal activity at a sublaminar resolution, much of which is locally cancelled (i.e., closed field). By virtue of the macroscopic scale of the scalp-recorded EEG, a surface Laplacian reflects the radial projections of these underlying currents, representing a unique, unambiguous measure of neuronal activity at scalp. Although the surface Laplacian requires minimal assumptions compared to complex, model-sensitive inverses, the resulting waveform topographies faithfully summarize and simplify essential constraints that must be placed on putative generators of a scalp potential topography, even if they arise from deep or partially-closed fields. CSD methods thereby provide a global empirical and biophysical context for generator localization, spanning scales from intracortical to scalp recordings.

  7. Comparison of Galvanic Currents Generated Between Different Combinations of Orthodontic Brackets and Archwires Using Potentiostat: An In Vitro Study

    PubMed Central

    Nayak, Rabindra S; Shafiuddin, Bareera; Pasha, Azam; Vinay, K; Narayan, Anjali; Shetty, Smitha V

    2015-01-01

    Background: Technological advances in wire selection and bracket design have led to improved treatment efficiency and allowed longer time intervals between appliance adjustments. The wires remain in the mouth for a longer duration and are subjected to electrochemical reactions, mechanical forces of mastication and generalized wear. These cause different types of corrosion. This study was done to compare the galvanic currents generated between different combinations of brackets and archwires commonly used in orthodontic practices. Materials and Methods: The materials used for the study included different commercially available orthodontic archwires and brackets. The galvanic current generated by individual materials and different combinations of these materials was tested and compared. The orthodontic archwires used were 0.019″ × 0.025″ heat-activated nickel-titanium (3M Unitek), 0.019″ × 0.025″ beta-titanium (3M Unitek) and 0.019″ × 0.025″ stainless steel (3M Unitek). The orthodontic brackets used were 0.022″ MBT laser-cut (Victory Series, 3M Unitek) and metal-injection molded (Leone Company) maxillary central incisor brackets respectively. The ligature wire used for ligation was 0.009″ stainless steel ligature (HP Company). The galvanic current for individual archwires, brackets, and the different bracket-archwire-ligature combinations was measured by using a Potentiostat machine. The data were generated using the Linear Sweep Voltammetry and OriginPro 8.5 Graphing and Data Analysis Softwares. The study was conducted in two phases. Phase I comprised of five groups for open circuit potential (OCP) and galvanic current (I), whereas Phase II comprised of six groups for galvanic current alone. Results: Mean, standard deviation and range were computed for the OCP and galvanic current (I) values obtained. Results were subjected to statistical analysis through ANOVA. In Phase I, higher mean OCP was recorded in stainless steel archwire, followed by beta

  8. Thrombolytic therapy reduces red blood cell aggregation in plasma without affecting intrinsic aggregability.

    PubMed

    Ben-Ami, R; Sheinman, G; Yedgar, S; Eldor, A; Roth, A; Berliner, A S; Barshtein, G

    2002-03-15

    Red blood cell (RBC) aggregation may contribute to occlusion of the coronary microcirculation during myocardial infarction. We studied the effect of thrombolytic therapy on RBC aggregation in patients with acute myocardial infarction (AMI). Compared with patients with myocardial infarction who did not receive thrombolytic therapy, those treated with systemic thrombolysis exhibited significantly reduced RBC aggregation, reduced plasma fibrinogen levels and increased plasma D-dimer levels. Using measurement of RBC aggregation in a standardized dextran-500 solution, reduction in RBC aggregation after thrombolysis was shown to be plasma dependent. Thrombolytic therapy had no direct effect on intrinsic RBC aggregability in patients with AMI. We conclude that thrombolytic therapy has rheologic consequences that may contribute to its overall efficacy. Inhibition of RBC aggregation by thrombolytic therapy may result from the degradation of fibrinogen, a key factor in the formation of RBC aggregates, and from the generation of fibrinogen degradation products capable of disaggregating RBCs.

  9. The generation of magnetic fields and electric currents in cometary plasma tails

    NASA Technical Reports Server (NTRS)

    Ip, W.-H.; Mendis, D. A.

    1976-01-01

    Due to the folding of the interplanetary magnetic field into the tail as a comet sweeps through the interplanetary medium, the magnetic field in the tail can be built up to the order of 100 gammas at a heliocentric distance of about 1 AU. This folding of magnetic flux tubes also results in a cross-tail electric current passing through a neutral sheet. When streams of enhanced plasma density merge with the main tail, cross-tail currents as large as 1 billion A may result. A condition could arise which causes a significant fraction of this current to be discharged through the inner coma, resulting in rapid ionization. The typical time scale for such outbursts of ionization is estimated to be of the order of 10,000 sec, which is in reasonable agreement with observation.

  10. Overview of Solar Wind-Magnetosphere-Ionosphere-Atmosphere Coupling and the Generation of Magnetospheric Currents

    NASA Astrophysics Data System (ADS)

    Milan, S. E.; Clausen, L. B. N.; Coxon, J. C.; Carter, J. A.; Walach, M.-T.; Laundal, K.; Østgaard, N.; Tenfjord, P.; Reistad, J.; Snekvik, K.; Korth, H.; Anderson, B. J.

    2017-03-01

    We review the morphology and dynamics of the electrical current systems of the terrestrial magnetosphere and ionosphere. Observations from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE) over the three years 2010 to 2012 are employed to illustrate the variability of the field-aligned currents that couple the magnetosphere and ionosphere, on timescales from minutes to years, in response to the impact of solar wind disturbances on the magnetosphere and changes in the level of solar illumination of the polar ionospheres. The variability is discussed within the context of the occurrence of magnetic reconnection between the solar wind and terrestrial magnetic fields at the magnetopause, the transport of magnetic flux within the magnetosphere, and the onset of magnetic reconnection in the magnetotail. The conditions under which the currents are expected to be weak, and hence minimally contaminate measurements of the internally-produced magnetic field of the Earth, are briefly outlined.

  11. Overview of Solar Wind-Magnetosphere-Ionosphere-Atmosphere Coupling and the Generation of Magnetospheric Currents

    NASA Astrophysics Data System (ADS)

    Milan, S. E.; Clausen, L. B. N.; Coxon, J. C.; Carter, J. A.; Walach, M.-T.; Laundal, K.; Østgaard, N.; Tenfjord, P.; Reistad, J.; Snekvik, K.; Korth, H.; Anderson, B. J.

    2017-02-01

    We review the morphology and dynamics of the electrical current systems of the terrestrial magnetosphere and ionosphere. Observations from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE) over the three years 2010 to 2012 are employed to illustrate the variability of the field-aligned currents that couple the magnetosphere and ionosphere, on timescales from minutes to years, in response to the impact of solar wind disturbances on the magnetosphere and changes in the level of solar illumination of the polar ionospheres. The variability is discussed within the context of the occurrence of magnetic reconnection between the solar wind and terrestrial magnetic fields at the magnetopause, the transport of magnetic flux within the magnetosphere, and the onset of magnetic reconnection in the magnetotail. The conditions under which the currents are expected to be weak, and hence minimally contaminate measurements of the internally-produced magnetic field of the Earth, are briefly outlined.

  12. Method and apparatus for generating motor current spectra to enhance motor system fault detection

    DOEpatents

    Linehan, Daniel J.; Bunch, Stanley L.; Lyster, Carl T.

    1995-01-01

    A method and circuitry for sampling periodic amplitude modulations in a nonstationary periodic carrier wave to determine frequencies in the amplitude modulations. The method and circuit are described in terms of an improved motor current signature analysis. The method insures that the sampled data set contains an exact whole number of carrier wave cycles by defining the rate at which samples of motor current data are collected. The circuitry insures that a sampled data set containing stationary carrier waves is recreated from the analog motor current signal containing nonstationary carrier waves by conditioning the actual sampling rate to adjust with the frequency variations in the carrier wave. After the sampled data is transformed to the frequency domain via the Discrete Fourier Transform, the frequency distribution in the discrete spectra of those components due to the carrier wave and its harmonics will be minimized so that signals of interest are more easily analyzed.

  13. Method and apparatus for generating motor current spectra to enhance motor system fault detection

    DOEpatents

    Linehan, D.J.; Bunch, S.L.; Lyster, C.T.

    1995-10-24

    A method and circuitry are disclosed for sampling periodic amplitude modulations in a nonstationary periodic carrier wave to determine frequencies in the amplitude modulations. The method and circuit are described in terms of an improved motor current signature analysis. The method insures that the sampled data set contains an exact whole number of carrier wave cycles by defining the rate at which samples of motor current data are collected. The circuitry insures that a sampled data set containing stationary carrier waves is recreated from the analog motor current signal containing nonstationary carrier waves by conditioning the actual sampling rate to adjust with the frequency variations in the carrier wave. After the sampled data is transformed to the frequency domain via the Discrete Fourier Transform, the frequency distribution in the discrete spectra of those components due to the carrier wave and its harmonics will be minimized so that signals of interest are more easily analyzed. 29 figs.

  14. Analysis of enhanced current-generating mechanism of Geobacter sulfurreducens strain via model-driven metabolism simulation.

    PubMed

    Meng, Jing; Xu, Zixiang; Guo, Jing; Yue, Yunxia; Sun, Xiao

    2013-01-01

    Microbial fuel cells (MFCs) are a class of ideal technologies that function via anaerobic respiration of electricigens, which bring current generation and environmental restoration together. An in-depth understanding of microbial metabolism is of great importance in engineering microbes to further improve their respiration. We employed flux balance analysis and selected Fe(iii) as a substitute for the electrode to simulate current-generating metabolism of Geobacter sulfurreducens PCA with a fixed acetate uptake rate. Simulation results indicated the fluxes of reactions directing acetate towards dissimilation to generate electrons increased under the suboptimal growth condition, resulting in an increase in the respiration rate and a decrease in the growth rate. The results revealed the competitive relationship between oxidative respiration and cell growth during the metabolism of microbe current generation. The results helped us quantitatively understand why microbes growing slowly have the potential to make good use of fuel in MFCs. At the same time, slow growth does not necessarily result in speedy respiration. Alternative respirations may exist under the same growth state due to redundant pathways in the metabolic network. The big difference between the maximum and minimum respiration mainly results from the total formate secretion. With iterative flux variability analysis, a relatively ideal model of variant of G. sulfurreducens PCA was reconstructed by deleting several enzymes in the wild model, which could reach simultaneous suboptimal growth and maximum respiration. Under this ideal condition, flux towards extracellular electron transfer rather than for biosynthesis is beneficial for the conversion of organic matter to electricity without large accumulations of biomass and electricigens may maximize utilization of limited fuel. Our simulations will provide an insight into the enhanced current-generating mechanism and identify theoretical range of respiration

  15. Analysis of Enhanced Current-Generating Mechanism of Geobacter sulfurreducens Strain via Model-Driven Metabolism Simulation

    PubMed Central

    Guo, Jing; Yue, Yunxia; Sun, Xiao

    2013-01-01

    Microbial fuel cells (MFCs) are a class of ideal technologies that function via anaerobic respiration of electricigens, which bring current generation and environmental restoration together. An in-depth understanding of microbial metabolism is of great importance in engineering microbes to further improve their respiration. We employed flux balance analysis and selected Fe(iii) as a substitute for the electrode to simulate current-generating metabolism of Geobacter sulfurreducens PCA with a fixed acetate uptake rate. Simulation results indicated the fluxes of reactions directing acetate towards dissimilation to generate electrons increased under the suboptimal growth condition, resulting in an increase in the respiration rate and a decrease in the growth rate. The results revealed the competitive relationship between oxidative respiration and cell growth during the metabolism of microbe current generation. The results helped us quantitatively understand why microbes growing slowly have the potential to make good use of fuel in MFCs. At the same time, slow growth does not necessarily result in speedy respiration. Alternative respirations may exist under the same growth state due to redundant pathways in the metabolic network. The big difference between the maximum and minimum respiration mainly results from the total formate secretion. With iterative flux variability analysis, a relatively ideal model of variant of G. sulfurreducens PCA was reconstructed by deleting several enzymes in the wild model, which could reach simultaneous suboptimal growth and maximum respiration. Under this ideal condition, flux towards extracellular electron transfer rather than for biosynthesis is beneficial for the conversion of organic matter to electricity without large accumulations of biomass and electricigens may maximize utilization of limited fuel. Our simulations will provide an insight into the enhanced current-generating mechanism and identify theoretical range of respiration

  16. Effects of an elastic scatterer on the DC spin current generation in a Rashba-type quantum channel

    NASA Astrophysics Data System (ADS)

    Wang, L. Y.; Tang, C. S.; Chu, C. S.

    2006-05-01

    In this work, we consider a Rashba-type quantum channel (RQC) consisting of one AC-biased finger-gates (FG) that orient perpendicularly and located above the RQC. Such an AC-biased FG gives rise to a local time-modulation in the Rashba coupling parameter, and is shown recently to generate a DC spin current [L.Y. Wang, C.S. Tang, C.S. Chu, Cond-mat/0409291, 2004]. No charge current, however, is generated in this configuration. We explore the robustness of such DC spin current generation against elastic scattering in the RQC. The effect of backscattering is studied by introducing a static barrier that is uniform in the transverse dimension. The effects of both backscattering and subband mixing is studied by introducing a static partial-barrier that is spatially localized and non-uniform in the transverse dimension. In addition, we compare the cases of attractive and repulsive partial-barriers. It is found that attractive partial-barrier gives rise to additional DC spin current structures due to resonant inter-subband and inter-sideband transition to quasi-bound states formed just beneath subband thresholds.

  17. Coupling mechanism of interface-induced generation-recombination current with the floating source in nMOSFET

    NASA Astrophysics Data System (ADS)

    Chen, Haifeng; Xie, Duan; Guo, Lixin

    2016-11-01

    This paper presents a detailed investigation of the interface trap-induced generation-recombination current IGR in an n-type MOSFET. Under the positive drain bias VD-step-mode measurement, IGR demonstrates some abnormal changes and even transforms from the generation current to the recombination current. These phenomena ascribe to the coupling mechanism of IGR with the floating source. The core of this mechanism is that the floating source leads to the variable ΔEFN, which is the difference of the electron's quasi-Fermi levels between the source and the drain. The plus-minus sign of ΔEFN determines the function of the interface trap serving as the generation or recombination center, and the magnitude of ΔEFN determines the shape of IGR curve. Additionally, the area Ω of IGR curve is introduced to verify and quantitatively describe this coupling mechanism. It is found that Ω has the linear relationship with ΔEFN and the slope is 19 p/eV. This coupling mechanism provides a potential way to control the pA current based on the interface trap.

  18. Does lightning destroy rocks?: Results from a laboratory lightning experiment using an impulse high-current generator

    NASA Astrophysics Data System (ADS)

    Wakasa, Sachi A.; Nishimura, Seisuke; Shimizu, Hiroyuki; Matsukura, Yukinori

    2012-08-01

    To understand the destruction of rocks and changes to landforms by lightning strikes, laboratory experiments of lightning strikes were performed using three kinds of rock samples as targets. Artificial lightning with known electric current was simulated by an impulse high-current generator in the laboratory. The artificial lightning is different to natural lightning. The high-current generator can generate up to 20 kA of electric current equal to 50% of the value of natural lightning, but up to 50 kV of electric voltage which is a tenth to hundredth that of natural lightning. Experimental results showed that the rock samples with low mechanical resistance, tuff and rhyolite, were destroyed, while the rock sample with high mechanical resistance, i.e., granite, was not broken by lightning strikes. These results indicate that natural lightning causes rocks and bedrock to break. These imply that lightning might change landforms, for example gnammas and fractures on tors and mountain peaks where lightning tends to strike.

  19. Metabolic modeling of spatial heterogeneity of biofilms in microbial fuel cells reveals substrate limitations in electrical current generation.

    PubMed

    Jayasinghe, Nadeera; Franks, Ashley; Nevin, Kelly P; Mahadevan, Radhakrishnan

    2014-10-01

    Microbial fuel cells (MFCs) have been proposed as an alternative energy resource for the conversion of organic compounds to electricity. In an MFC, microorganisms such as Geobacter sulfurreducens form an anode-associated biofilm that can completely oxidize organic matter (electron donor) to carbon dioxide with direct electron transfer to the anode (electron acceptor). Mathematical models are useful in analyzing biofilm processes; however, existing models rely on Nernst-Monod type expressions, and evaluate extracellular processes separated from the intracellular metabolism of the microorganism. Thus, models that combine both extracellular and intracellular components, while addressing spatial heterogeneity, are essential for improved representation of biofilm processes. The goal of this work is to develop a model that integrates genome-scale metabolic models with the model of biofilm environment. This integrated model shows the variations of electrical current production and biofilm thickness under the presence/absence of NH4 in the bulk solution, and under varying maintenance energy demands. Further, sensitivity analysis suggested that conductivity is not limiting electrical current generation and that increasing cell density can lead to enhanced current generation. In addition, the modeling results also highlight instances such as the transformation into respiring cells, where the mechanism of electrical current generation during biofilm development is not yet clearly understood.

  20. Generation and Characterization of Electron Bunches with Ramped Current Profiles in a Dual-Frequency Superconducting Linear Accelerator

    DOE PAGES

    Piot, P.; Behrens, C.; Gerth, C.; ...

    2011-09-07

    We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radiofrequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced {approx} 700-MeV bunches have peak currents of the order of a kilo-Ampere. Data taken for various accelerator settings demonstrate the versatility of the method and in particular its ability to produce current profiles that have a quasi-linear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak acceleratingmore » electric fields with transformer ratios larger than 2 in dielectric-lined waveguides.« less

  1. Generation and characterization of electron bunches with ramped current profiles in a dual-frequency superconducting linear accelerator.

    PubMed

    Piot, P; Behrens, C; Gerth, C; Dohlus, M; Lemery, F; Mihalcea, D; Stoltz, P; Vogt, M

    2012-01-20

    We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radio frequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced ~700-MeV bunches have peak currents of the order of a kilo-Ampère. Data taken for various accelerator settings demonstrate the versatility of the method and, in particular, its ability to produce current profiles that have a quasilinear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak accelerating electric fields with transformer ratios larger than 2 in dielectric-lined waveguides.

  2. Generation and Characterization of Electron Bunches with Ramped Current Profiles in a Dual-Frequency Superconducting Linear Accelerator

    SciTech Connect

    Piot, P.; Behrens, C.; Gerth, C.; Dohlus, M.; Lemery, F.; Mihalcea, D.; Stoltz, P.; Vogt, M.

    2011-09-07

    We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radiofrequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced {approx} 700-MeV bunches have peak currents of the order of a kilo-Ampere. Data taken for various accelerator settings demonstrate the versatility of the method and in particular its ability to produce current profiles that have a quasi-linear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak accelerating electric fields with transformer ratios larger than 2 in dielectric-lined waveguides.

  3. Generation of Relativistic Electron Bunches with Arbitrary Current Distribution via Transverse-to-Longitudinal Phase Space Exchange

    SciTech Connect

    Piot, P.; Sun, Y.-E; Power, J.G.; Rihaoui, M.; /NICADD, DeKalb

    2010-07-01

    We propose a general method for tailoring the current distribution of relativistic electron bunches. The technique relies on a recently proposed method to exchange the longitudinal phase space emittance with one of the transverse emittances. The method consists of transversely shaping the bunch and then converting its transverse profile into a current profile via a transverse-to-longitudinal phase-space-exchange beamline. We show that it is possible to tailor the current profile to follow, in principle, any desired distributions. We demonstrate, via computer simulations, the application of the method to generate trains of microbunches with tunable spacing and linearly-ramped current profiles. We also briefly explore potential applications of the technique.

  4. Current Grid Generation Strategies and Future Requirements in Hypersonic Vehicle Design, Analysis and Testing

    NASA Technical Reports Server (NTRS)

    Papadopoulos, Periklis; Venkatapathy, Ethiraj; Prabhu, Dinesh; Loomis, Mark P.; Olynick, Dave; Arnold, James O. (Technical Monitor)

    1998-01-01

    Recent advances in computational power enable computational fluid dynamic modeling of increasingly complex configurations. A review of grid generation methodologies implemented in support of the computational work performed for the X-38 and X-33 are presented. In strategizing topological constructs and blocking structures factors considered are the geometric configuration, optimal grid size, numerical algorithms, accuracy requirements, physics of the problem at hand, computational expense, and the available computer hardware. Also addressed are grid refinement strategies, the effects of wall spacing, and convergence. The significance of grid is demonstrated through a comparison of computational and experimental results of the aeroheating environment experienced by the X-38 vehicle. Special topics on grid generation strategies are also addressed to model control surface deflections, and material mapping.

  5. Protein engineering for metabolic engineering: current and next-generation tools

    PubMed Central

    Marcheschi, Ryan J.; Gronenberg, Luisa S.; Liao, James C.

    2014-01-01

    Protein engineering in the context of metabolic engineering is increasingly important to the field of industrial biotechnology. As the demand for biologically-produced food, fuels, chemicals, food additives, and pharmaceuticals continues to grow, the ability to design and modify proteins to accomplish new functions will be required to meet the high productivity demands for the metabolism of engineered organisms. This article reviews advances of selecting, modeling, and engineering proteins to improve or alter their activity. Some of the methods have only recently been developed for general use and are just beginning to find greater application in the metabolic engineering community. We also discuss methods of generating random and targeted diversity in proteins to generate mutant libraries for analysis. Recent uses of these techniques to alter cofactor use, produce non-natural amino acids, alcohols, and carboxylic acids, and alter organism phenotypes are presented and discussed as examples of the successful engineering of proteins for metabolic engineering purposes. PMID:23589443

  6. Effect of second-generation antipsychotics on cognition: current issues and future challenges

    PubMed Central

    Hill, S Kristian; Bishop, Jeffrey R; Palumbo, Donna; Sweeney, John A.

    2010-01-01

    Generalized cognitive impairments are stable deficits linked to schizophrenia and key factors associated with functional disability in the disorder. Preclinical data suggest that second-generation antipsychotics could potentially reduce cognitive impairments; however, recent large clinical trials indicate only modest cognitive benefits relative to first-generation antipsychotics. This might reflect a limited drug effect in humans, a differential drug effect due to brain alterations associated with schizophrenia, or limited sensitivity of the neuropsychological tests for evaluating cognitive outcomes. New adjunctive procognitive drugs may be needed to achieve robust cognitive and functional improvement. Drug discovery may benefit from greater utilization of translational neurocognitive biomarkers to bridge preclinical and clinical proof-of-concept studies, to optimize assay sensitivity, enhance cost efficiency, and speed progress in drug development. PMID:20021320

  7. Protein engineering for metabolic engineering: Current and next-generation tools

    SciTech Connect

    Marcheschi, RJ; Gronenberg, LS; Liao, JC

    2013-04-16

    Protein engineering in the context of metabolic engineering is increasingly important to the field of industrial biotechnology. As the demand for biologically produced food, fuels, chemicals, food additives, and pharmaceuticals continues to grow, the ability to design and modify proteins to accomplish new functions will be required to meet the high productivity demands for the metabolism of engineered organisms. We review advances in selecting, modeling, and engineering proteins to improve or alter their activity. Some of the methods have only recently been developed for general use and are just beginning to find greater application in the metabolic engineering community. We also discuss methods of generating random and targeted diversity in proteins to generate mutant libraries for analysis. Recent uses of these techniques to alter cofactor use; produce non-natural amino acids, alcohols, and carboxylic acids; and alter organism phenotypes are presented and discussed as examples of the successful engineering of proteins for metabolic engineering purposes.

  8. Recommended practice for fire protection for electric generating plants and high voltage direct current converter stations. 2005 ed.

    SciTech Connect

    2005-07-01

    The standard outlines fire safety recommendations for gas, oil, coal, and alternative fuel electric generating plants including high voltage direct current converter stations and combustion turbine units greater than 7500 hp used for electric generation. Provisions apply to both new and existing plants. The document provides fire prevention and fire protection recommendations for the: safety of construction and operating personnel; physical integrity of plant components; and continuity of plant operations. The 2005 edition includes revisions and new art that clarify existing provisions. 5 annexes.

  9. Eddy Generation at a Convex Corner by a Coastal Current in a Rotating System

    DTIC Science & Technology

    1992-03-01

    Volume flux calculations based on the sur- face velocity revealed vertical shear which increased with gyre size. Hydraulic models were also applied to...Theoretical Studies ............................. 23 1.4. Plan of the Thesis ........ ............................ 30 I 2. Hydraulic Models of...and Kase, Beckmann, and Hinricksen (1989). Their models suggest that meddies are broken off from the Mediterranean Outflow by stronger currents above

  10. Analysis of Advanced Fuel Assemblies and Core Designs for the Current and Next Generations of LWRs

    SciTech Connect

    Ragusa, Jean; Vierow, Karen

    2011-09-01

    The objective of the project is to design and analyze advanced fuel assemblies for use in current and future light water reactors and to assess their ability to reduce the inventory of transuranic elements, while preserving operational safety. The reprocessing of spent nuclear fuel can delay or avoid the need for a second geological repository in the US. Current light water reactor fuel assembly designs under investigation could reduce the plutonium inventory of reprocessed fuel. Nevertheless, these designs are not effective in stabilizing or reducing the inventory of minor actinides. In the course of this project, we developed and analyzed advanced fuel assembly designs with improved thermal transmutation capability regarding transuranic elements and especially minor actinides. These designs will be intended for use in thermal spectrum (e.g., current and future fleet of light water reactors in the US). We investigated various fuel types, namely high burn-up advanced mixed oxides and inert matrix fuels, in various geometrical designs that are compliant with the core internals of current and future light water reactors. Neutronic/thermal hydraulic effects were included. Transmutation efficiency and safety parameters were used to rank and down-select the various designs.

  11. Optical Generation of Ballistic and Diffusive Spin Currents in Organic-Inorganic Lead Halide Perovskites

    NASA Astrophysics Data System (ADS)

    Li, Junwen; Haney, Paul

    Organic-inorganic halide perovskite solar cells have attracted enormous attention in recent years due to their remarkable photovoltaic power conversion efficiency. These materials should exhibit interesting spin-dependent properties as well, owing to the strong spin-orbit coupling and the broken inversion symmetry present at room temperature. In this work, we consider the spin-dependent optical response of CH3NH3PbI3 on two distinct time scales. We first use density functional theory to compute the ballistic spin current injected by absorption of linearly polarized light. This spin current persists on a time scale of the momentum relaxation time. We then consider diffusive transport of photogenerated charge and spin for a thin perovskite layer with a passivated surface and an Ohmic, non-selective back contact. The spin densities and spin currents are evaluated by solving the drift-diffusion equations for a 3-dimensional Rashba model. We comment on the applications of optically excited spin densities and spin currents in these materials.

  12. The Self-Consistent Generation of Current Sheets in Astrophysical Plasma Turbulence

    NASA Astrophysics Data System (ADS)

    Howes, Gregory

    2014-10-01

    In space and astrophysical plasma turbulence, it has long been recognized that dissipation occurs predominantly in intermittent current sheets, with vigorous activity in the past few years focused on obtaining observational evidence for such localized dissipation in the near-Earth solar wind. The nature of these magnetic discontinuities and their associated current sheets measured in the solar wind remains unclear--are these discontinuities due to filamentary magnetic structure in the solar wind, or do they arise dynamically from turbulent interactions? Recent analytical solution, numerical validation, and experimental verification of the nonlinear energy transfer in Alfven wave collisions, the nonlinear interactions between counterpropagating Alfven waves, has established this interaction as the fundamental building block of astrophysical plasma turbulence. Here I will present first-principles analytical calculations and supporting numerical simulations that Alfven wave collisions in the strong turbulence limit naturally produce current sheets, providing the first theoretical unification of models of plasma turbulence mediated by Alfven waves with ideas on localized dissipation in current sheets. Supported by NSF CAREER Award AGS-1054061, NSF Grant PHY-10033446, and NASA Grant NNX10AC91G.

  13. Analysis of a Van de Graaff Generator for EMP Direct Current Survivability Testing

    DTIC Science & Technology

    2013-03-01

    Conference on Nikola Tesla , Farmingville, New York, 2006. [16] T & M Research Products, "SERIES SDN-414 Current Viewing Resistors Description," [Online...Accessed 18 October 2012]. 101 [15] G. L. Johnson, " Tesla Coil Impedance," in The First Tesla Museum and Science Center International

  14. NASA's Current and Next Generation Coastal Remote Sensing Missions and Coral Reef Projects.

    NASA Technical Reports Server (NTRS)

    Guild, Liane S.

    2015-01-01

    The LLILAS Faculty Research Initiative presents a two-day symposium, Caribbean Coral Reefs at Risk. This international symposium examines the current state and future of coral reef conservation efforts throughout the Caribbean from the perspective of government agencies, nongovernment organizations, and academia.

  15. Rhenium-188: Availability from the W-188/Re-188 Generator and Status of Current Applications

    SciTech Connect

    Pillai, M R A; Dash, A; Knapp Jr, Russ F

    2012-01-01

    Rhenium-188 is one of the most readily available generator derived and useful radionuclides for therapy emitting - particles (2.12 MeV, 71.1% and 1.965 MeV, 25.6%) and imageable gammas (155 KeV, 15.1%). The 188W/188Re generator is an ideal source for the long term (4-6 months) continuous availability of no carrier added (nca) 188Re suitable for the preparation of radiopharmaceuticals for radionuclide therapy. The challenges associated with the double neutron capture route of production of the parent 188W radionuclide have been a major impediment in the progress of application of 188Re. Tungsten-188 of adequate specific activity can be prepared only in 2-3 of the high flux reactors operating in the World. Several useful technologies have been developed for the preparation of clinical grade 188W/188Re generator. Since the specific activity of 188W used in the generator is relatively low (<5 Ci/g), the eluted 188ReO4- can have low radioactive concentration often insufficient for radiopharmaceutical preparation. However, several efficient post elution concentration techniques have been developed that yield clinically useful 188ReO4-. Rhenium-188 has been used for the preparation of therapeutic radiopharmaceuticals for the management of diseases such as bone metastasis, rheumatoid arthritis and primary cancers. Several early phase clinical studies using radiopharmaceuticals based on 188Re-labeled phosphonates, antibodies, peptides, lipiodol and particulates have been reported. This article reviews the availability, and use of188Re including a discussion of why broader use of 188Re has not progressed as ecpected as a popular radionuclide for therapy.

  16. Eddy Current Signature Classification of Steam Generator Tube Defects Using A Learning Vector Quantization Neural Network

    SciTech Connect

    Gabe V. Garcia

    2005-01-03

    A major cause of failure in nuclear steam generators is degradation of their tubes. Although seven primary defect categories exist, one of the principal causes of tube failure is intergranular attack/stress corrosion cracking (IGA/SCC). This type of defect usually begins on the secondary side surface of the tubes and propagates both inwards and laterally. In many cases this defect is found at or near the tube support plates.

  17. Rhenium-188: availability from the (188)W/(188)Re generator and status of current applications.

    PubMed

    Pillai, M R A; Dash, Ashutosh; Knapp, F F

    2012-07-01

    Rhenium-188 is one of the most readily available generator derived and useful radionuclides for therapy emitting β(-) particles (2.12 MeV, 71.1% and 1.965 MeV, 25.6%) and imageable gammas (155 keV, 15.1%). The (188)W/(188)Re generator is an ideal source for the long term (4-6 months) continuous availability of no carrier added (nca) (188)Re suitable for the preparation of radiopharmaceuticals for radionuclide therapy. The challenges associated with the double neutron capture route of production of the parent (188)W radionuclide have been a major impediment in the progress of application of (188)Re. Tungsten-188 of adequate specific activity can be prepared only in 2-3 of the high flux reactors operating in the World. Several useful technologies have been developed for the preparation of clinical grade (188)W/(188)Re generators. Since the specific activity of (188)W used in the generator is relatively low 185 GBq( < 5 Ci)/g], the eluted (188)ReO(4)(-) can have low radioactive concentration often insufficient for radiopharmaceutical preparation. However, several efficient post elution concentration techniques have been developed that yield clinically useful (188)ReO(4)(-) solutions. Rhenium-188 has been used for the preparation of therapeutic radiopharmaceuticals for the management of diseases such as bone metastasis, rheumatoid arthritis and primary cancers. Several early phase clinical studies using radiopharmaceuticals based on (188)Re-labeled phosphonates, antibodies, peptides, lipiodol and particulates have been reported. This article reviews the availability and use of (188)Re including a discussion of why broader use of (188)Re has not progressed as expected as a popular radionuclide for therapy.

  18. Historical and Current U.S. Strategies for Boosting Distributed Generation (Chinese Translation)

    SciTech Connect

    Lowder, Travis; Schwabe, Paul; Zhou, Ella; Arent, Douglas J.

    2015-08-01

    This is the Chinese translation of NREL/TP-6A20-64843. This report seeks to introduce a variety of top-down and bottom-up practices that, in concert with the macro-environment of cost-reduction globally and early adoption in Europe, helped boost the distributed generation photovoltaic market in the United States. These experiences may serve as a reference in China's quest to promote distributed renewable energy.

  19. Small file aggregation in a parallel computing system

    DOEpatents

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Grider, Gary; Zhang, Jingwang

    2014-09-02

    Techniques are provided for small file aggregation in a parallel computing system. An exemplary method for storing a plurality of files generated by a plurality of processes in a parallel computing system comprises aggregating the plurality of files into a single aggregated file; and generating metadata for the single aggregated file. The metadata comprises an offset and a length of each of the plurality of files in the single aggregated file. The metadata can be used to unpack one or more of the files from the single aggregated file.

  20. Correlated spin currents generated by resonant-crossed Andreev reflections in topological superconductors.

    PubMed

    He, James J; Wu, Jiansheng; Choy, Ting-Pong; Liu, Xiong-Jun; Tanaka, Y; Law, K T

    2014-01-01

    Topological superconductors, which support Majorana fermion excitations, have been the subject of intense studies due to their novel transport properties and their potential applications in fault-tolerant quantum computations. Here we propose a new type of topological superconductors that can be used as a novel source of correlated spin currents. We show that inducing superconductivity on a AIII class topological insulator wire, which respects a chiral symmetry and supports protected fermionic end states, will result in a topological superconductor. This topological superconductor supports two topological phases with one or two Majorana fermion end states, respectively. In the phase with two Majorana fermions, the superconductor can split Cooper pairs efficiently into electrons in two spatially separated leads due to Majorana-induced resonant-crossed Andreev reflections. The resulting currents in the leads are correlated and spin-polarized. Importantly, the proposed topological superconductors can be realized using quantum anomalous Hall insulators in proximity to superconductors.

  1. Erythrocyte aggregation: basic aspects and clinical importance.

    PubMed

    Baskurt, Oguz K; Meiselman, Herbert J

    2013-01-01

    Red blood cell (RBC) aggregate to form two- and three-dimensional structures when suspended in aqueous solutions containing large plasma proteins or polymers; this aggregation is reversible and shear dependent (i.e., dispersed at high shear and reformed at low or stasis). The extent of aggregation is the main determinant of low shear blood viscosity, thus predicting an inverse relationship between aggregation and in vivo blood flow. However, the effects of aggregation on hemodynamic mechanisms (e.g., plasma skimming, Fåhraeus Effect, microvascular hematocrit) may promote rather than impede vascular blood flow. The impact of enhanced RBC aggregation on endothelial function and hemostatic mechanisms adds further complexity, thereby requiring specific attention to the nature, extent and time course of aggregation when considering its overall influence on tissue perfusion. A detailed understanding of aggregation effects is important from a clinical point of view since it may be enhanced during a variety of pathophysiological processes, including infections, circulatory and metabolic disorders, hematological pathologies and several other disease states. Altered RBC aggregation may be an indicator of disease as well as a factor affecting the course of the clinical condition; the prognostic value of RBC aggregation indices has been demonstrated in various diseases. Currently, RBC aggregation is an easily and accurately measurable parameter, and therefore may be expected to have broader clinical usage in the future.

  2. Partially coherent fundamental Gaussian wave generated by a fluctuating planar current source.

    PubMed

    Seshadri, S R

    2010-06-01

    The propagation characteristics of a spatially localized electromagnetic wave produced by a planar current source of different states of spatial coherence are analyzed by the use of a Gaussian Schell-model source. A linearly polarized fundamental electromagnetic Gaussian wave with the electric field perpendicular to the direction of propagation is treated. The effects of the degree of coherence of the source distribution on the radiation intensity distribution and the total radiated power are determined.

  3. Mouse SGLT3a generates proton-activated currents but does not transport sugar.

    PubMed

    Barcelona, Stephanie; Menegaz, Danusa; Díez-Sampedro, Ana

    2012-04-15

    Sodium-glucose cotransporters (SGLTs) are secondary active transporters belonging to the SLC5 gene family. SGLT1, a well-characterized member of this family, electrogenically transports glucose and galactose. Human SGLT3 (hSGLT3), despite sharing a high amino acid identity with human SGLT1 (hSGLT1), does not transport sugar, although functions as a sugar sensor. In contrast to humans, two different genes in mice and rats code for two different SGLT3 proteins, SGLT3a and SGLT3b. We previously cloned and characterized mouse SGLT3b (mSGLT3b) and showed that, while it does transport sugar like SGLT1, it likely functions as a physiological sugar sensor like hSGLT3. In this study, we cloned mouse SGLT3a (mSGLT3a) and characterized it by expressing it in Xenopus laevis oocytes and performing electrophysiology and sugar transport assays. mSGLT3a did not transport sugar, and sugars did not induce currents at pH 7.4, though acidic pH induced inward currents that increased in the presence of sugar. Moreover, mutation of residue 457 from glutamate to glutamine resulted in a Na(+)-dependent transport of sugar that was inhibited by phlorizin. To corroborate our results in oocytes, we expressed and characterized mSGLT3a in mammalian cells and confirmed our findings. In addition, we cloned, expressed, and characterized rat SGLT3a in oocytes and found characteristics similar to mSGLT3a. In summary, acidic pH induces currents in mSGLT3a, and sugar-induced currents are increased at acidic pH, but wild-type SGLT3a does not transport sugar.

  4. Computer Generated Imagery (CGI) Current Technology and Cost Measures Feasibility Study.

    DTIC Science & Technology

    1980-09-26

    4-10 4-5 VITAL Visual System Block Diagram ............... 4-15 4-6 Singer-Link Image Processing Hardware ........... 4-19 4-7 Block Diagram Of...SCENE I and II systems which are described in Table E-1. G.E.’s current real time systems process three cycles concurrently. These computation cycles... processing ; bus interface; active face, block, cluster, and region assignment; and vector processing . The opera- tion of each sequencer is basically

  5. Crystallographic orientation and electrode nature are key factors for electric current generation by Geobacter sulfurreducens.

    PubMed

    Maestro, Beatriz; Ortiz, Juan M; Schrott, Germán; Busalmen, Juan P; Climent, Víctor; Feliu, Juan M

    2014-08-01

    We have investigated the influence of electrode material and crystallographic structure on electron transfer and biofilm formation of Geobacter sulfurreducens. Single-crystal gold-Au(110), Au(111), Au(210)-and platinum-Pt(100), Pt(110), Pt(111), Pt(210)-electrodes were tested and compared to graphite rods. G. sulfurreducens electrochemically interacts with all these materials with different attachment kinetics and final current production, although redox species involved in the electron transfer to the anode are virtually the same in all cases. Initial bacterial colonization was fastest on graphite up to the monolayer level, whereas gold electrodes led to higher final current densities. Crystal geometry was shown to have an important influence, with Au(210) sustaining a current density of up to 1442±101μAcm(-2) at the steady state, over Au(111) with 961±94μAcm(-2) and Au(110) with 944±89μAcm(-2). On the other hand, the platinum electrodes displayed the lowest performances, including Pt(210). Our results indicate that both crystal geometry and electrode material are key parameters for the efficient interaction of bacteria with the substrate and should be considered for the design of novel materials and microbial devices to optimize energy production.

  6. Duty Cycling Influences Current Generation in Multi-Anode Environmental Microbial Fuel Cells

    SciTech Connect

    Gardel, EJ; Nielsen, ME; Grisdela, PT; Girguis, PR

    2012-05-01

    Improving microbial fuel cell (MFC) performance continues to be the subject of research, yet the role of operating conditions, specifically duty cycling, on MFC performance has been modestly addressed. We present a series of studies in which we use a 15-anode environmental MFC to explore how duty cycling (variations in the time an anode is connected) influences cumulative charge, current, and microbial composition. The data reveal particular switching intervals that result in the greatest time-normalized current. When disconnection times are sufficiently short, there is a striking decrease in current due to an increase in the overall electrode reaction resistance. This was observed over a number of whole cell potentials. Based on these results, we posit that replenishment of depleted electron donors within the biofilm and surrounding diffusion layer is necessary for maximum charge transfer, and that proton flux may be not limiting in the highly buffered aqueous phases that are common among environmental MFCs. Surprisingly, microbial diversity analyses found no discernible difference in gross community composition among duty cycling treatments, suggesting that duty cycling itself has little or no effect. Such duty cycling experiments are valuable in determining which factors govern performance of bioelectrochemical systems and might also be used to optimize field-deployed systems.

  7. Real-time natural soundscape generation based on current weather conditions for workspace voice-masking

    NASA Astrophysics Data System (ADS)

    Riggs, Caitlin

    Sound masking in work spaces has been implemented to decrease likelihood of distraction from work tasks and improve speech privacy. Current uses of noise as maskers commonly apply broadband white or pink noise signals due to their perceived neutrality. This research combines work into the restorative properties of exposure to nature/natural sounds and pilot studies of natural sounds as maskers to suggest a noise-masking system of 'natural' sounds. This system composes a natural soundscape in real time determined by the current weather and time of day such that the masking audio is aesthetically pleasing and informative about the outside world in addition to providing improved speech privacy and reducing distraction when compared to a setting with no masking system. Currently there is no experimental foundation to suggest that restoration or slowed attentional fatigue can occur if this type of alternative masking sound is presented during a task. This implementation of a dynamic, immersive soundscape masker begins the investigation into the practical efficacy of such a masking system.

  8. Secondary magnetic islands generated by the Kelvin-Helmholtz instability in a reconnecting current sheet.

    PubMed

    Fermo, R L; Drake, J F; Swisdak, M

    2012-06-22

    Magnetic islands or flux ropes produced by magnetic reconnection have been observed on the magnetopause, in the magnetotail, and in coronal current sheets. Particle-in-cell simulations of magnetic reconnection with a guide field produce elongated electron current layers that spontaneously produce secondary islands. Here, we explore the seed mechanism that gives birth to these islands. The most commonly suggested theory for island formation is the tearing instability. We demonstrate that in our simulations these structures typically start out, not as magnetic islands, but as electron flow vortices within the electron current sheet. When some of these vortices first form, they do not coincide with closed magnetic field lines, as would be the case if they were islands. Only after they have grown larger than the electron skin depth do they couple to the magnetic field and seed the growth of finite-sized islands. The streaming of electrons along the magnetic separatrix produces the flow shear necessary to drive an electron Kelvin-Helmholtz instability and produce the initial vortices. The conditions under which this instability is the dominant mechanism for seeding magnetic islands are explored.

  9. Investigation of eddy current examination on OD fatigue crack for steam generator tubes

    NASA Astrophysics Data System (ADS)

    Kong, Yuying; Ding, Boyuan; Li, Ming; Liu, Jinhong; Chen, Huaidong; Meyendorf, Norbert G.

    2015-03-01

    The opening width of fatigue crack was very small, and conventional Bobbin probe was very difficult to detect it in steam generator tubes. Different sizes of 8 fatigue cracks were inspected using bobbin probe rotating probe. The analysis results showed that, bobbin probe was not sensitive for fatigue crack even for small through wall crack mixed with denting signal. On the other hand, the rotating probe was easily to detect all cracks. Finally, the OD phase to depth curve for fatigue crack using rotating probe was established and the results agreed very well with the true crack size.

  10. Large Deviation Generating Function for Currents in the Pauli-Fierz Model

    NASA Astrophysics Data System (ADS)

    de Roeck, Wojciech

    We consider a finite quantum system coupled to quasifree thermal reservoirs at different temperatures. We construct the statistics of energy transport between the reservoirs and we show that the corresponding large deviation generating function exists and it is analytic on a compact set. This result is valid for small coupling and exponentially decaying reservoir correlation functions. Our technique consists of a diagrammatic expansion that uses the Markovian limit of the system as a reference. As a corollary, we derive the Gallavotti-Cohen fluctuation relation for the entropy production.

  11. The selection of convertible engines with current gas generator technology for high speed rotorcraft

    NASA Technical Reports Server (NTRS)

    Eisenberg, Joseph D.

    1990-01-01

    NASA-Lewis has sponsored two studies to determine the most promising convertible engine concepts for high speed rotorcraft. These studies projected year 2000 convertible technology limited to present gas generator technology. Propulsion systems for utilization on aircraft needing thrust only during cruise and those aircraft needing both power and thrust at cruise were investigated. Mission calculations for the two contractors involved were based upon the fold tilt rotor concept. Analysis and comparison of the General Electric concepts (geared UDF, clutched fan, and VIGV fan), and the Allison Gas Turbine concepts (clutched fan, VIGV fan, variable pitch fan, single rotation tractor propfan, and counter rotation tractor propfan) are presented.

  12. Uniform magnetic fields generated by circular current-carrying coils. [for spacecraft

    NASA Technical Reports Server (NTRS)

    Williams, V. L.; Cain, J. C.

    1975-01-01

    The study described was carried out to evaluate known systems of circular coils with a view toward their application on board the space probes Ranger 1, Ranger 2, and Explorer 10. Particular attention is given to a new method, developed during the investigation, for determining the constants of systems composed of 6 to 8 coils. Such systems were found to generate magnetic fields of very high uniformity. By using advanced computational techniques, it proved possible to evaluate the field uniformity of various systems without recourse to complex analytical methods. Means of evaluating the influence of coil dimensions on the uniformity of the field of any system are described.

  13. The selection of convertible engines with current gas generator technology for high speed rotorcraft

    NASA Technical Reports Server (NTRS)

    Eisenberg, Joseph D.

    1990-01-01

    NASA-Lewis sponsored two studies to determine the most promising convertible engine concepts for high speed rotorcraft. These studies projected year 2000 convertible technology limited to present gas generator technology. Propulsion systems for utilization on aircraft needing thrust only during cruise and those aircraft needing both power and thrust at cruise were investigated. Mission calculations for the two contractors involved were based upon the fold tilt rotor concept. Analysis and comparison of the General Electric concepts (geared UDF, clutched fan, and Variable Inlet Guide Vane (VIGV) fan), and the Allison Gas Turbine concepts (clutched fan, VIGV fan, variable pitch fan, single rotation tractor propfan, and counter rotation tractor propfan) are presented.

  14. The effects of storms and storm-generated currents on sand beaches in Southern Maine, USA

    USGS Publications Warehouse

    Hill, H.W.; Kelley, J.T.; Belknap, D.F.; Dickson, S.M.

    2004-01-01

    Storms are one of the most important controls on the cycle of erosion and accretion on beaches. Current meters placed in shoreface locations of Saco Bay and Wells Embayment, ME, recorded bottom currents during the winter months of 2000 and 2001, while teams of volunteers profiled the topography of nearby beaches. Coupling offshore meteorological and beach profile data made it possible to determine the response of nine beaches in southern Maine to various oceanographic and meteorological conditions. The beaches selected for profiling ranged from pristine to completely developed and permitted further examination of the role of seawalls on the response of beaches to storms. Current meters documented three unique types of storms: frontal passages, southwest storms, and northeast storms. In general, the current meter results indicate that frontal passages and southwest storms were responsible for bringing sediment towards the shore, while northeast storms resulted in a net movement of sediment away from the beach. During the 1999-2000 winter, there were a greater percentage of frontal passages and southwest storms, while during the 2000-2001 winter, there were more northeast storms. The sediment that was transported landward during the 1999-2000 winter was reworked into the berm along moderately and highly developed beaches during the next summer. A northeast storm on March 5-6, 2001, resulted in currents in excess of 1 m s-1 and wave heights that reached six meters. The storm persisted over 10 high tides and caused coastal flooding and property damage. Topographic profiles made before and after the storm demonstrate that developed beaches experienced a loss of sediment volume during the storm, while sediment was redistributed along the profile on moderately developed and undeveloped beaches. Two months after the storm, the profiles along the developed beaches had not reached their pre-storm elevation. In comparison, the moderately developed and undeveloped beaches

  15. Polymer-based protein engineering grown ferrocene-containing redox polymers improve current generation in an enzymatic biofuel cell.

    PubMed

    Campbell, Alan S; Murata, Hironobu; Carmali, Sheiliza; Matyjaszewski, Krzysztof; Islam, Mohammad F; Russell, Alan J

    2016-12-15

    Enzymatic biofuel cells (EBFCs) are capable of generating electricity from physiologically present fuels making them promising power sources for the future of implantable devices. The potential application of such systems is limited, however, by inefficient current generation. Polymer-based protein engineering (PBPE) offers a unique method to tailor enzyme function through tunable modification of the enzyme surface with functional polymers. In this study, we report on the modification of glucose oxidase (GOX) with ferrocene-containing redox polymers to increase current generation efficiency in an enzyme-modified anode. Poly(N-(3-dimethyl(ferrocenyl)methylammonium bromide)propyl acrylamide) (pFcAc) was grown from covalently attached, water-soluble initiator molecules on the surface of GOX in a "grafting-from" approach using atom transfer radical polymerization (ATRP). The covalently-coupled ferrocene-containing polymers on the enzyme surface promoted the effective "wiring" of the GOX active site to an external electrode. The resulting GOX-pFcAc conjugates generated over an order of magnitude increase in current generation efficiency and a 4-fold increase in maximum EBFC power density (≈1.7µWcm(-2)) with similar open circuit voltage (0.27V) compared to native GOX when physically adsorbed onto paddle-shaped electrodes made up of electrospun polyacrylonitrile fibers coated with gold nanoparticles and multi-wall carbon nanotubes. The formation of electroactive enzyme-redox polymer conjugates using PBPE represents a powerful new tool for the improvement of mediated enzyme-based bioelectronics without the need for free redox mediators or anode/cathode compartmentalization.

  16. Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions.

    PubMed

    Kumar, Sandeep; Thangakani, A Mary; Nagarajan, R; Singh, Satish K; Velmurugan, D; Gromiha, M Michael

    2016-02-29

    Why do patients suffering from neurodegenerative diseases generate autoantibodies that selectively bind soluble aggregates of amyloidogenic proteins? Presently, molecular basis of interactions between the soluble aggregates and human immune system is unknown. By analyzing sequences of experimentally validated T-cell autoimmune epitopes, aggregating peptides, amyloidogenic proteins and randomly generated peptides, here we report overlapping regions that likely drive aggregation as well as generate autoantibodies against the aggregates. Sequence features, that make short peptides susceptible to aggregation, increase their incidence in human T-cell autoimmune epitopes by 4-6 times. Many epitopes are predicted to be significantly aggregation prone (aggregation propensities ≥10%) and the ones containing experimentally validated aggregating regions are enriched in hydrophobicity by 10-20%. Aggregate morphologies also influence Human Leukocyte Antigen (HLA)--types recognized by the aggregating regions containing epitopes. Most (88%) epitopes that contain amyloid fibril forming regions bind HLA-DR, while majority (63%) of those containing amorphous β-aggregating regions bind HLA-DQ. More than two-thirds (70%) of human amyloidogenic proteins contain overlapping regions that are simultaneously aggregation prone and auto-immunogenic. Such regions help clear soluble aggregates by generating selective autoantibodies against them. This can be harnessed for early diagnosis of proteinopathies and for drug/vaccine design against them.

  17. The Next Generation Advanced Video Guidance Sensor: Flight Heritage and Current Development

    NASA Astrophysics Data System (ADS)

    Howard, Richard T.; Bryan, Thomas C.

    2009-03-01

    The Next Generation Advanced Video Guidance Sensor (NGAVGS) is the latest in a line of sensors that have flown four times in the last 10 years. The NGAVGS has been under development for the last two years as a long-range proximity operations and docking sensor for use in an Automated Rendezvous and Docking (AR&D) system. The first autonomous rendezvous and docking in the history of the U.S. Space Program was successfully accomplished by Orbital Express, using the Advanced Video Guidance Sensor (AVGS) as the primary docking sensor. That flight proved that the United States now has a mature and flight proven sensor technology for supporting Crew Exploration Vehicles (CEV) and Commercial Orbital Transport Systems (COTS) Automated Rendezvous and Docking (AR&D). NASA video sensors have worked well in the past: the AVGS used on the Demonstration of Autonomous Rendezvous Technology (DART) mission operated successfully in "spot mode" out to 2 km, and the first generation rendezvous and docking sensor, the Video Guidance Sensor (VGS), was developed and successfully flown on Space Shuttle flights in 1997 and 1998.

  18. Statistical characteristic in time-domain of direct current corona-generated audible noise from conductor in corona cage

    NASA Astrophysics Data System (ADS)

    Li, Xuebao; Cui, Xiang; Lu, Tiebing; Ma, Wenzuo; Bian, Xingming; Wang, Donglai; Hiziroglu, Huseyin

    2016-03-01

    The corona-generated audible noise (AN) has become one of decisive factors in the design of high voltage direct current (HVDC) transmission lines. The AN from transmission lines can be attributed to sound pressure pulses which are generated by the multiple corona sources formed on the conductor, i.e., transmission lines. In this paper, a detailed time-domain characteristics of the sound pressure pulses, which are generated by the DC corona discharges formed over the surfaces of a stranded conductors, are investigated systematically in a laboratory settings using a corona cage structure. The amplitude of sound pressure pulse and its time intervals are extracted by observing a direct correlation between corona current pulses and corona-generated sound pressure pulses. Based on the statistical characteristics, a stochastic model is presented for simulating the sound pressure pulses due to DC corona discharges occurring on conductors. The proposed stochastic model is validated by comparing the calculated and measured A-weighted sound pressure level (SPL). The proposed model is then used to analyze the influence of the pulse amplitudes and pulse rate on the SPL. Furthermore, a mathematical relationship is found between the SPL and conductor diameter, electric field, and radial distance.

  19. Broadband sidebands generated by parametric instability in lower hybrid current drive experiments on EAST

    SciTech Connect

    Amicucci, L. Castaldo, C.; Cesario, R.; Giovannozzi, E.; Tuccillo, A. A.; Ding, B. J.; Li, M. H.

    2015-12-10

    Modern research on nuclear fusion energy, based on the tokamak concept, has strong need of tools for actively driving non-inductive current especially at the periphery of plasma column, where tools available so far have poor efficiency. This is essential for solving one of the most critical problems for thermonuclear reactor, consisting in how to achieve the figure of fusion gain in the context of sufficient stability. The lower hybrid current drive (LHCD) effect has the potential capability of driving current at large radii of reactor plasma with high efficiency [1]. Experiments recently carried out on EAST showed that a strong activity of LH sideband waves (from the RF probe spectra), accompanied by weak core penetration of the coupled LH power, is present when operating at relatively high plasma densities. Previous theoretical results, confirmed by experiments on FTU, showed that the LH sideband phenomenon is produced by parametric instability (PI), which are mitigated by higher plasma edge temperatures. This condition is thus useful for enabling the LH power propagation when operating with profiles having high plasma densities even at the edge. In the present work, we show new PI modeling of EAST plasmas data, obtained in condition of higher plasma edge temperature due to chamber lithisation. The obtained trend of the PI frequencies and growth rates is consistent with data of RF probe spectra, available in different regimes of lithisated and not lithisated vessel. Moreover, these spectra are interpreted as PI effect occurring at the periphery of plasma column, however in the low field side where the LH power is coupled.

  20. Broadband sidebands generated by parametric instability in lower hybrid current drive experiments on EAST

    NASA Astrophysics Data System (ADS)

    Amicucci, L.; Ding, B. J.; Castaldo, C.; Cesario, R.; Giovannozzi, E.; Li, M. H.; Tuccillo, A. A.

    2015-12-01

    Modern research on nuclear fusion energy, based on the tokamak concept, has strong need of tools for actively driving non-inductive current especially at the periphery of plasma column, where tools available so far have poor efficiency. This is essential for solving one of the most critical problems for thermonuclear reactor, consisting in how to achieve the figure of fusion gain in the context of sufficient stability. The lower hybrid current drive (LHCD) effect has the potential capability of driving current at large radii of reactor plasma with high efficiency [1]. Experiments recently carried out on EAST showed that a strong activity of LH sideband waves (from the RF probe spectra), accompanied by weak core penetration of the coupled LH power, is present when operating at relatively high plasma densities. Previous theoretical results, confirmed by experiments on FTU, showed that the LH sideband phenomenon is produced by parametric instability (PI), which are mitigated by higher plasma edge temperatures. This condition is thus useful for enabling the LH power propagation when operating with profiles having high plasma densities even at the edge. In the present work, we show new PI modeling of EAST plasmas data, obtained in condition of higher plasma edge temperature due to chamber lithisation. The obtained trend of the PI frequencies and growth rates is consistent with data of RF probe spectra, available in different regimes of lithisated and not lithisated vessel. Moreover, these spectra are interpreted as PI effect occurring at the periphery of plasma column, however in the low field side where the LH power is coupled.

  1. A CMOS current-mode log(x) and log(1/x) functions generator

    NASA Astrophysics Data System (ADS)

    Al-Absi, Munir A.; Al-Tamimi, Karama M.

    2014-08-01

    A novel Complementary Metal Oxide Semiconductor (CMOS) current-mode low-voltage and low-power controllable logarithmic function circuit is presented. The proposed design utilises one Operational Transconductance Amplifier (OTA) and two PMOS transistors biased in weak inversion region. The proposed design provides high dynamic range, controllable amplitude, high accuracy and is insensitive to temperature variations. The circuit operates on a ±0.6 V power supply and consumes 0.3 μW. The functionality of the proposed circuit was verified using HSPICE with 0.35 μm 2P4M CMOS process technology.

  2. Electromagnetic Fields from the Generation and Absorption of Discontinuous Linear Current Fronts.

    DTIC Science & Technology

    1984-07-01

    transform in ways that are obvious from inspection of Figure 3.1. Thus E- Ec oso+ E sine (3.36) Ee - - Ez sine + Er cos( (3.X37) z Ez /ER Er * 0 Figure 3.1...is concluded that (a) the radial or R-field of the moving charge cancels the field of the stationary charge giving no net radial field, (b) the tangen ...appropriate amplitude and time scales. For example; a current Impulse in the form of a delta - function can be modelled by a positive step-function followed

  3. Arc driver operation for either efficient energy transfer or high-current generator

    NASA Technical Reports Server (NTRS)

    Dannenberg, R. E.; Silva, A. F.

    1972-01-01

    An investigation is made to establish predictable electric arcs along triggered paths for research purposes, the intended application being the heating of the driver gas of a 1 MJ electrically driven shock tube. Trigger conductors consisting of wires, open tubes, and tubes pressurized with different gases were investigated either on the axis of the arc chamber or spiraled along the chamber walls. Design criteria are presented for successful arc initiation with reproducible voltage-current characteristics. Results are compared with other facilities and several application areas are discussed.

  4. Generation of spin-polarized currents via cross-relaxation with dynamically pumped paramagnetic impurities

    SciTech Connect

    Meriles, Carlos A.; Doherty, Marcus W.

    2014-07-14

    Key to future spintronics and spin-based information processing technologies is the generation, manipulation, and detection of spin polarization in a solid state platform. Here, we theoretically explore an alternative route to spin injection via the use of dynamically polarized nitrogen-vacancy (NV) centers in diamond. We focus on the geometry where carriers and NV centers are confined to proximate, parallel layers and use a “trap-and-release” model to calculate the spin cross-relaxation probabilities between the charge carriers and neighboring NV centers. We identify near-unity regimes of carrier polarization depending on the NV spin state, applied magnetic field, and carrier g-factor. In particular, we find that unlike holes, electron spins are distinctively robust against spin-lattice relaxation by other, unpolarized paramagnetic centers. Further, the polarization process is only weakly dependent on the carrier hopping dynamics, which makes this approach potentially applicable over a broad range of temperatures.

  5. Current and future greenhouse gas emissions associated with electricity generation in China: implications for electric vehicles.

    PubMed

    Shen, Wei; Han, Weijian; Wallington, Timothy J

    2014-06-17

    China's oil imports and greenhouse gas (GHG) emissions have grown rapidly over the past decade. Addressing energy security and GHG emissions is a national priority. Replacing conventional vehicles with electric vehicles (EVs) offers a potential solution to both issues. While the reduction in petroleum use and hence the energy security benefits of switching to EVs are obvious, the GHG benefits are less obvious. We examine the current Chinese electric grid and its evolution and discuss the implications for EVs. China's electric grid will be dominated by coal for the next few decades. In 2015 in Beijing, Shanghai, and Guangzhou, EVs will need to use less than 14, 19, and 23 kWh/100 km, respectively, to match the 183 gCO2/km WTW emissions for energy saving vehicles. In 2020, in Beijing, Shanghai, and Guangzhou EVs will need to use less than 13, 18, and 20 kWh/100 km, respectively, to match the 137 gCO2/km WTW emissions for energy saving vehicles. EVs currently demonstrated in China use 24-32 kWh/100 km. Electrification will reduce petroleum imports; however, it will be very challenging for EVs to contribute to government targets for GHGs emissions reduction.

  6. Current experiences with internet telepathology and possible evolution in the next generation of Internet services.

    PubMed

    Della Mea, V; Beltrami, C A

    2000-01-01

    The last five years experience has definitely demonstrated the possible applications of the Internet for telepathology. They may be listed as follows: (a) teleconsultation via multimedia e-mail; (b) teleconsultation via web-based tools; (c) distant education by means of World Wide Web; (d) virtual microscope management through Web and Java interfaces; (e) real-time consultations through Internet-based videoconferencing. Such applications have led to the recognition of some important limits of the Internet, when dealing with telemedicine: (i) no guarantees on the quality of service (QoS); (ii) inadequate security and privacy; (iii) for some countries, low bandwidth and thus low responsiveness for real-time applications. Currently, there are several innovations in the world of the Internet. Different initiatives have been aimed at an amelioration of the Internet protocols, in order to have quality of service, multimedia support, security and other advanced services, together with greater bandwidth. The forthcoming Internet improvements, although induced by electronic commerce, video on demand, and other commercial needs, are of real interest also for telemedicine, because they solve the limits currently slowing down the use of Internet. When such new services will be available, telepathology applications may switch from research to daily practice in a fast way.

  7. Direct optical detection of current induced spin accumulation in metals by magnetization-induced second harmonic generation

    SciTech Connect

    Pattabi, A. Gu, Z.; Yang, Y.; Finley, J.; Lee, O. J.; Raziq, H. A.; Gorchon, J.; Salahuddin, S.; Bokor, J.

    2015-10-12

    Strong spin-orbit coupling in non-magnetic heavy metals has been shown to lead to large spin currents flowing transverse to a charge current in such a metal wire. This in turn leads to the buildup of a net spin accumulation at the lateral surfaces of the wire. Spin-orbit torque effects enable the use of the accumulated spins to exert useful magnetic torques on adjacent magnetic layers in spintronic devices. We report the direct detection of spin accumulation at the free surface of nonmagnetic metal films using magnetization-induced optical surface second harmonic generation. The technique is applied to probe the current induced surface spin accumulation in various heavy metals such as Pt, β-Ta, and Au with high sensitivity. The sensitivity of the technique enables us to measure the time dynamics on a sub-ns time scale of the spin accumulation arising from a short current pulse. The ability of optical surface second harmonic generation to probe interfaces suggests that this technique will also be useful for studying the dynamics of spin accumulation and transport across interfaces between non-magnetic and ferromagnetic materials, where spin-orbit torque effects are of considerable interest.

  8. Ash Aggregates in Proximal Settings

    NASA Astrophysics Data System (ADS)

    Porritt, L. A.; Russell, K.

    2012-12-01

    Ash aggregates are thought to have formed within and been deposited by the eruption column and plume and dilute density currents and their associated ash clouds. Moist, turbulent ash clouds are considered critical to ash aggregate formation by facilitating both collision and adhesion of particles. Consequently, they are most commonly found in distal deposits. Proximal deposits containing ash aggregates are less commonly observed but do occur. Here we describe two occurrences of vent proximal ash aggregate-rich deposits; the first within a kimberlite pipe where coated ash pellets and accretionary lapilli are found within the intra-vent sequence; and the second in a glaciovolcanic setting where cored pellets (armoured lapilli) occur within <1 km of the vent. The deposits within the A418 pipe, Diavik Diamond Mine, Canada, are the residual deposits within the conduit and vent of the volcano and are characterised by an abundance of ash aggregates. Coated ash pellets are dominant but are followed in abundance by ash pellets, accretionary lapilli and rare cored pellets. The coated ash pellets typically range from 1 - 5 mm in diameter and have core to rim ratios of approximately 10:1. The formation and preservation of these aggregates elucidates the style and nature of the explosive phase of kimberlite eruption at A418 (and other pipes?). First, these pyroclasts dictate the intensity of the kimberlite eruption; it must be energetic enough to cause intense fragmentation of the kimberlite to produce a substantial volume of very fine ash (<62 μm). Secondly, the ash aggregates indicate the involvement of moisture coupled with the presence of dilute expanded eruption clouds. The structure and distribution of these deposits throughout the kimberlite conduit demand that aggregation and deposition operate entirely within the confines of the vent; this indicates that aggregation is a rapid process. Ash aggregates within glaciovolcanic sequences are also rarely documented. The

  9. Frequency spectrum of focused broadband pulses of electromagnetic radiation generated by polarization currents with superluminally rotating distribution patterns.

    PubMed

    Ardavan, Houshang; Ardavan, Arzhang; Singleton, John

    2003-11-01

    We investigate the spectral features of the emission from a superluminal polarization current whose distribution pattern rotates (with an angular frequency omega) and oscillates (with a frequency omega > omega differing from an integral multiple of omega) at the same time. This type of polarization current is found in recent practical machines designed to investigate superluminal emission. Although all of the processes involved are linear, we find that the broadband emission contains frequencies that are higher than omega by a factor of the order of (omega/omega)2. This generation of frequencies not required for the creation of the source stems from mathematically rigorous consequences of the familiar classical expression for the retarded potential. The results suggest practical applications for superluminal polarization currents as broadband radio-frequency and infrared sources.

  10. Robust, easily shaped, and epoxy-free carbon-fiber-aluminum cathodes for generating high-current electron beams.

    PubMed

    Liu, Lie; Li, Limin; Wen, Jianchun; Wan, Hong

    2009-02-01

    This paper presents the construction of carbon-fiber-aluminum (CFA) cathode by squeezing casting and its applications for generating high-current electron beams to drive high-power microwave sources. The fabrication process avoided using epoxy, a volatile deteriorating the vacuum system. These cathodes had a higher hardness than conventional aluminum, facilitating machining. After surface treatment, carbon fibers became the dominator determining emission property. A multineedle CFA cathode was utilized in a triode virtual cathode oscillator (vircator), powered by a approximately 450 kV, approximately 400 ns pulse. It was found that 300-400 MW, approximately 250 ns microwave was radiated at a dominant frequency of 2.6 GHz. Further, this cathode can endure high-current-density emission without detectable degradation in performance as the pulse shot proceeded, showing the robust nature of carbon fibers as explosive emitters. Overall, this new class of cold cathodes offers a potential prospect of developing high-current electron beam sources.

  11. Generation of pure spin currents via spin Seebeck effect in self-biased hexagonal ferrite thin films

    SciTech Connect

    Li, Peng; Ellsworth, David; Chang, Houchen; Janantha, Praveen; Richardson, Daniel; Phillips, Preston; Vijayasarathy, Tarah; Wu, Mingzhong; Shah, Faisal

    2014-12-15

    Light-induced generation of pure spin currents in a Pt(2.5 nm)/BaFe{sub 12}O{sub 19}(1.2 μm)/sapphire(0.5 mm) structure is reported. The BaFe{sub 12}O{sub 19} film had strong in-plane uniaxial anisotropy and was therefore self-biased. Upon exposure to light, a temperature difference (ΔT) was established across the BaFe{sub 12}O{sub 19} thickness that gave rise to a pure spin current in the Pt via the spin Seebeck effect. Via the inverse spin Hall effect, the spin current produced an electric voltage across one of the Pt lateral dimensions. The voltage varied with time in the same manner as ΔT and flipped its sign when the magnetization in BaFe{sub 12}O{sub 19} was reversed.

  12. Current generation by helicons and lower hybrid waves in modern tokamaks and reactors ITER and DEMO. Scenarios, modeling and antennae

    SciTech Connect

    Vdovin, V. L.

    2013-02-15

    The innovative concept and 3D full-wave code modeling the off-axis current drive by radio-frequency (RF) waves in large-scale tokamaks, ITER and DEMO, for steady-state operation with high efficiency is proposed. The scheme uses the helicon radiation (fast magnetosonic waves at high (20-40) ion cyclotron frequency harmonics) at frequencies of 500-700 MHz propagating in the outer regions of the plasmas with a rotational transform. It is expected that the current generated by helicons, in conjunction with the bootstrap current, ensure the maintenance of a given value of the total current in the stability margin q(0) {>=} 2 and q(a) {>=} 4, and will help to have regimes with a negative magnetic shear and internal transport barrier to ensure stability at high normalized plasma pressure {beta}{sub N} > 3 (the so-called advanced scenarios) of interest for the commercial reactor. Modeling with full-wave three-dimensional codes PSTELION and STELEC showed flexible control of the current profile in the reactor plasmas of ITER and DEMO, using multiple frequencies, the positions of the antennae and toroidal wave slow down. Also presented are the results of simulations of current generation by helicons in the DIII-D, T-15MD, and JT-60AS tokamaks. Commercially available continuous-wave klystrons of the MW/tube range are promising for commercial stationary fusion reactors. The compact antennae of the waveguide type are proposed, and an example of a possible RF system for today's tokamaks is given. The advantages of the scheme (partially tested at lower frequencies in tokamaks) are a significant decline in the role of parametric instabilities in the plasma periphery, the use of electrically strong resonator-waveguide type antennae, and substantially greater antenna-plasma coupling.

  13. Labile aggregation stimulating substance, free fatty acids, and platelet aggregation.

    PubMed

    Gerrard, J M; White, J G; Krivit, W

    1976-01-01

    Labile aggregation stimulating substance (LASS), an intermediate produced during platelet biosynthesis of PGE2 and PGF2alpha, acts as a physiologic intercellular messenger to promote platelet aggregation and the release reaction. The activity is formed by intact cells after physiologic stimulation or can be generated from platelet membrane fractions after combination with arachidonate. In the present investigation, small amounts of polyunsaturated fatty acids added to an incubation mixture of platelet microsomes and arachidonate were found to significantly inhibit subsequent platelet aggregation. Saturated and mono-unsaturated fatty acids in the same concentrations were without effect. However, in higher concentrations mono-unsaturated fatty acids were found to be inhibitory and stearic acid was found to enhance subsequent platelet aggregation. The inhibition caused by the polyunsaturated fatty acid, linoleate, was shown to be the result of an effect on the production of LASS through an interaction with the platelet enzyme responsible for conversion of arachidonate to LASS. In contrast, stearic acid was found to enhance platelet aggregation by acting on the platelets and not directly on LASS production. The results suggest that small changes in the fatty acid composition of platelet phospholipids could significantly influence platelet reactivity.

  14. Generation of Soluble Advanced Glycation End Products Receptor (sRAGE)-Binding Ligands during Extensive Heat Treatment of Whey Protein/Lactose Mixtures Is Dependent on Glycation and Aggregation.

    PubMed

    Liu, Fahui; Teodorowicz, Małgorzata; Wichers, Harry J; van Boekel, Martinus A J S; Hettinga, Kasper A

    2016-08-24

    Heating of protein- and sugar-containing materials is considered the primary factor affecting the formation of advanced glycation end products (AGEs). This study aimed to investigate the influence of heating conditions, digestion, and aggregation on the binding capacity of AGEs to the soluble AGE receptor (sRAGE). Samples consisting of mixtures of whey protein and lactose were heated at 130 °C. An in vitro infant digestion model was used to study the influence of heat treatment on the digestibility of whey proteins. The amount of sRAGE-binding ligands before and after digestion was measured by an ELISA-based sRAGE-binding assay. Water activity did not significantly affect the extent of digestibility of whey proteins dry heated at pH 5 (ranging from 3.3 ± 0.2 to 3.6 ± 0.1% for gastric digestion and from 53.5 ± 1.5 to 64.7 ± 1.1% for duodenal digestion), but there were differences in cleavage patterns of peptides among the samples heated at different pH values. Formation of sRAGE-binding ligands depended on the formation of aggregates and was limited in the samples heated at pH 5. Moreover, the sRAGE-binding activity of digested sample was changed by protease degradation and correlated with the digestibility of samples. In conclusion, generation of sRAGE-binding ligands during extensive heat treatment of whey protein/lactose mixtures is limited in acidic heating condition and dependent on glycation and aggregation.

  15. Current status of PET imaging of differentiated thyroid cancer with second generation radiopharmaceuticals.

    PubMed

    Lauri, C; Di Traglia, S; Galli, F; Pizzichini, P; Signore, A

    2015-03-01

    Although the prognosis of differentiated thyroid cancer (DTC) is favorable, some histotypes show worst clinical outcome and higher risk of recurrence. Serum thyroglobulin (Tg) levels and 131I-whole-body-scan (WBS), together with neck ultrasound (US), represent the golden standard for DTC follow-up. Nevertheless, the relatively high frequency of patients with high Tg levels and negative WBS requires further investigations by using new imaging modalities. The availability of whole body positron emission tomography (PET) methods, in parallel with the advances in radiochemistry, offer a wide substrate for many solutions. To this day ¹⁸F-fluoro-deoxy-glucose (¹⁸F-FDG) PET/CT still represents the imaging of choice in follow-up of patients with high serum Tg and negative ¹³¹I-WBS but in the last decades the research has focused on finding "second generation" radiopharmaceuticals for PET imaging, with both diagnostic and prognostic purposes, aiming to change the way to image thyroid cancer. Moreover, the use of various PET radiopharmaceuticals, that offer the possibility to explore different pathways involved in thyroid cancer, could find important applications in the near future for clinical decision making in order to program tailored treatments and follow-up. It would be desirable to use the same radiopharmaceutical for both imaging and dosimetric purpose to achieve a tailored therapy. Many efforts are focused in this direction and ¹²⁴I-PET/CT is now emerging as a valid tool in restaging and therapy management of DTC with promising results. Although the preliminary data available in literature require a confirmation in larger studies with longer follow-up, we think that in next future ¹²⁴I-PET/CT could gain an important role for management of DTC. The aim of this review was to perform a systematic analysis of literature describing the state of art of "second generation" PET-radiopharmaceuticals for imaging DTC. Discussion is focused on the utility of

  16. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit.

    PubMed

    Verheijck, E E; van Ginneken, A C; Bourier, J; Bouman, L N

    1995-04-01

    The role of the delayed rectifier current (IK) in impulse generation was studied in single sinoatrial nodal myocytes of the rabbit. We used the class III antiarrhythmic drug E-4031, which blocks IK in rabbit ventricular myocytes. In single sinoatrial nodal cells, E-4031 (0.1 mumol/L) significantly prolonged cycle length and action potential duration, depolarized maximum diastolic potential, and reduced both the upstroke velocity of the action potential and the diastolic depolarization rate. Half of the cells were arrested completely. At higher concentrations (1 and 10 mumol/L), spontaneous activity ceased in all cells. Three ionic currents fundamental for pacemaking, ie, IK, the long-lasting inward calcium current (ICa,L), and the hyperpolarization-activated current (I(f)), were studied by using the whole-cell and amphotericin-perforated patch technique. E-4031 blocked part of the outward current during depolarizing steps as well as the tail current upon subsequent repolarization (ITD) in a dose-dependent manner. E-4031 (10 mumol/L) depressed ITD (88 +/- 4%) (n = 6), reduced peak ICa,L at 0 mV (29 +/- 15%) (n = 4), but did not affect I(f). Lower concentrations did not affect ICa,L. Additional use of 5 mumol/L nifedipine demonstrated that ITD is carried in part by a calcium-sensitive current. Interestingly, complete blockade of IK and ICa,L unmasked the presence of a background current component with a reversal potential of -32 +/- 5.4 mV (n = 8) and a conductance of 39.5 +/- 5.6 pS/pF, which therefore can contribute both to the initial part of repolarization and to full diastolic depolarization.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. Flow structure and transport characteristics of feeding and exchange currents generated by upside-down Cassiopea jellyfish.

    PubMed

    Santhanakrishnan, Arvind; Dollinger, Makani; Hamlet, Christina L; Colin, Sean P; Miller, Laura A

    2012-07-15

    Quantifying the flows generated by the pulsations of jellyfish bells is crucial for understanding the mechanics and efficiency of their swimming and feeding. Recent experimental and theoretical work has focused on the dynamics of vortices in the wakes of swimming jellyfish with relatively simple oral arms and tentacles. The significance of bell pulsations for generating feeding currents through elaborate oral arms and the consequences for particle capture are not as well understood. To isolate the generation of feeding currents from swimming, the pulsing kinematics and fluid flow around the benthic jellyfish Cassiopea spp. were investigated using a combination of videography, digital particle image velocimetry and direct numerical simulation. During the rapid contraction phase of the bell, fluid is pulled into a starting vortex ring that translates through the oral arms with peak velocities that can be of the order of 10 cm s(-1). Strong shear flows are also generated across the top of the oral arms throughout the entire pulse cycle. A coherent train of vortex rings is not observed, unlike in the case of swimming oblate medusae such as Aurelia aurita. The phase-averaged flow generated by bell pulsations is similar to a vertical jet, with induced flow velocities averaged over the cycle of the order of 1-10 mm s(-1). This introduces a strong near-horizontal entrainment of the fluid along the substrate and towards the oral arms. Continual flow along the substrate towards the jellyfish is reproduced by numerical simulations that model the oral arms as a porous Brinkman layer of finite thickness. This two-dimensional numerical model does not, however, capture the far-field flow above the medusa, suggesting that either the three-dimensionality or the complex structure of the oral arms helps to direct flow towards the central axis and up and away from the animal.

  18. Miscibility Evaluation Of The Next Generation Solvent With Polymers Currently Used At DWPF, MCU, And Saltstone

    SciTech Connect

    Fondeur, F. F.

    2013-04-17

    The Office of Waste Processing, within the Office of Technology Innovation and Development, funded the development of an enhanced Caustic-Side Solvent Extraction (CSSX) solvent for deployment at the Savannah River Site for removal of cesium from High Level Waste. This effort lead to the development of the Next Generation Solvent (NGS) with Tris (3,7-dimethyl octyl) guanidine (TiDG). The first deployment target for the NGS solvent is within the Modular CSSX Unit (MCU). Deployment of a new chemical within an existing facility requires verification that the new chemical components are compatible with the installed equipment. In the instance of a new organic solvent, the primary focus is on compatibility of the solvent with organic polymers used in the affected facility. This report provides the calculated data from exposing these polymers to the Next Generation Solvent. An assessment of the dimensional stability of polymers known to be used or present in the MCU, Defense Waste Processing Facility (DWPF), and Saltstone facilities that will be exposed to the NGS showed that TiDG could selectively affect the elastomers and some thermoplastics to varying extents, but the typical use of these polymers in a confined geometry will likely prevent the NGS from impacting component performance. The polymers identified as of primary concern include Grafoil® (flexible graphite), Tefzel®, Isolast®, ethylene-propylene-diene monomer (EPDM) rubber, nitrile-butadiene rubber (NBR), styrene-butadiene rubber (SBR), ultra high molecular weight polyethylene (UHMWPE), and fluorocarbon rubber (FKM). Certain polymers like NBR and EPDM were found to interact mildly with NGS but their calculated swelling and the confined geometry will impede interaction with NGS. In addition, it was found that Vellumoid (cellulose fibers-reinforced glycerin and protein) may leach protein and Polyvinyl Chloride (PVC) may leach plasticizer (such as Bis-Ethylhexyl-Phthalates) into the NGS solvent. Either case

  19. Generation of complex motor patterns in american grasshopper via current-controlled thoracic electrical interfacing.

    PubMed

    Giampalmo, Susan L; Absher, Benjamin F; Bourne, W Tucker; Steves, Lida E; Vodenski, Vassil V; O'Donnell, Peter M; Erickson, Jonathan C

    2011-01-01

    Micro-air vehicles (MAVs) have attracted attention for their potential application to military applications, environmental sensing, and search and rescue missions. While progress is being made toward fabrication of a completely human-engineered MAV, another promising approach seeks to interface to, and take control of, an insect's nervous system. Cyborg insects take advantage of their innate exquisite loco-motor, navigation, and sensing abilities. Recently, several groups have demonstrated the feasibility of radio-controlled flight in the hawkmoth and beetle via electrical neural interfaces. Here, we report a method for eliciting the "jump" response in the American grasshopper (S. Americana). We found that stimulating the metathoracic T3 ganglion with constant-current square wave pulses with amplitude 186 ± 40 μA and frequency 190 ± 13 Hz reproducibly evoked (≥95% success rate) the desired motor activity in N=3 test subjects. To the best of our knowledge, this is the first report of an insect cyborg with a synchronous neuromuscular system.

  20. Influence of a new generation of operations support systems on current spacecraft operations philosophy: The users feedback

    NASA Technical Reports Server (NTRS)

    Darroy, Jean Michel

    1993-01-01

    Current trends in the spacecraft mission operations area (spacecraft & mission complexity, project duration, required flexibility are requiring a breakthrough for what concerns philosophy, organization, and support tools. A major evolution is related to space operations 'informationalization', i.e adding to existing operations support & data processing systems a new generation of tools based on advanced information technologies (object-oriented programming, artificial intelligence, data bases, hypertext) that automate, at least partially, operations tasks that used be performed manually (mission & project planning/scheduling, operations procedures elaboration & execution, data analysis & failure diagnosis). All the major facets of this 'informationalization' are addressed at MATRA MARCONI SPACE, operational applications were fielded and generic products are becoming available. These various applications have generated a significant feedback from the users (at ESA, CNES, ARIANESPACE, MATRA MARCONI SPACE), which is now allowing us to precisely measure how the deployment of this new generation of tools, that we called OPSWARE, can 'reengineer' current spacecraft mission operations philosophy, how it can make space operations faster, better, and cheaper. This paper can be considered as an update of the keynote address 'Knowledge-Based Systems for Spacecraft Control' presented during the first 'Ground Data Systems for Spacecraft Control' conference in Darmstadt, June 1990, with a special emphasis on these last two years users feedback.

  1. Current microseismicity and generating faults in the Gyeongju area, southeastern Korea

    NASA Astrophysics Data System (ADS)

    Han, Minhui; Kim, Kwang-Hee; Son, Moon; Kang, Su Young

    2017-01-01

    A study of microseismicity in a 15 × 20 km2 subregion of Gyeongju, southeastern Korea, establishes a direct link between minor earthquakes and known fault structures. The study area has a complex history of tectonic deformation and has experienced large historic earthquakes, with small earthquakes recorded since the beginning of modern instrumental monitoring. From 5 years of continuously recorded local seismic data, 311 previously unidentified microearthquakes can be reliably located using the double-difference algorithm. These newly discovered events occur in linear streaks that can be spatially correlated with active faults, which could pose a serious hazard to nearby communities. At-risk infrastructure includes the largest industrial park in South Korea, nuclear power plants, and disposal facilities for radioactive waste. The current work suggests that the southern segment of the Yeonil Tectonic Line and segments of the Seokup and Waup Basin boundary faults are active. For areas with high rates of microseismic activity, reliably located hypocenters are spatially correlated with mapped faults; in less active areas, earthquake clusters tend to occur at fault intersections. Microearthquakes in stable continental regions are known to exist, but have been largely ignored in assessments of seismic hazard because their magnitudes are well below the detection thresholds of seismic networks. The total number of locatable microearthquakes could be dramatically increased by lowering the triggering thresholds of network detection algorithms. The present work offers an example of how microearthquakes can be reliably detected and located with advanced techniques. This could make it possible to create a new database to identify subsurface fault geometries and modes of fault movement, which could then be considered in the assessments of seismic hazard in regions where major earthquakes are rare.

  2. Local and global aspects of charge-current generating world-sheet scalar potentials

    NASA Astrophysics Data System (ADS)

    Davidson, Aharon; Wali, Kameshwar C.

    1991-02-01

    The electromagnetic interactions of a test string, including in particular the intrinsic self-interactions, are governed by its charge-current two-vector density Qα ( α= τ, σ). Being locally conserved, Qα is derivable from a parent world-sheet scalar potential V( τ, σ), that is, Qα = ɛαβVβ. However, to characterize the electromagnetic properties of the string does not mean a priori specifying V( τ, σ) up to a global gauge transformation. In fact, it is only when V( τ, σ) is treated as an additional canonical variable that the superconductivity integrability constraint emerges as an equation of motion. Electric charge quantization then follows, exclusively for closed strings, provided the phase e iV stays single-valued with respect to the σ-periodicity ( Δσ = 2 π) in exactly the same way as the global property of the built-in phase e iV of an order parameter dictates magnetic flux quantization. The pedagogical case of a self-interacting circular loop, for which V=ƒ(τ)+nσ ⇔ χ = g(τ) + mσ, with n(m) counting the total number of electric charges (magnetic fluxons), is studied in the framework of two reparametrization invariant models. Following a Nielsen-Olsen type model, we advocate a novel approach to unification, with V (rather than χ) serving as the fifth dimension. The alternate model, favored on field-theoretical grounds, conceptually differs from the first one by strictly forbidding the collapse of a self-interacting loop.

  3. Thermodynamics of Protein Aggregation

    NASA Astrophysics Data System (ADS)

    Osborne, Kenneth L.; Barz, Bogdan; Bachmann, Michael; Strodel, Birgit

    Amyloid protein aggregation characterizes many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Creutz- feldt-Jakob disease. Evidence suggests that amyloid aggregates may share similar aggregation pathways, implying simulation of full-length amyloid proteins is not necessary for understanding amyloid formation. In this study we simulate GNNQQNY, the N-terminal prion-determining domain of the yeast protein Sup35 to investigate the thermodynamics of structural transitions during aggregation. We use a coarse-grained model with replica-exchange molecular dynamics to investigate the association of 3-, 6-, and 12-chain GNNQQNY systems and we determine the aggregation pathway by studying aggregation states of GN- NQQNY. We find that the aggregation of the hydrophilic GNNQQNY sequence is mainly driven by H-bond formation, leading to the formation of /3-sheets from the very beginning of the assembly process. Condensation (aggregation) and ordering take place simultaneously, which is underpinned by the occurrence of a single heat capacity peak only.

  4. Municipal solid waste generation in growing urban areas in Africa: current practices and relation to socioeconomic factors in Jimma, Ethiopia.

    PubMed

    Getahun, T; Mengistie, E; Haddis, A; Wasie, F; Alemayehu, E; Dadi, D; Van Gerven, T; Van der Bruggen, B

    2012-10-01

    As one of cities in the developing countries, a rapid population growth and industrial activities pose many environmental challenges for Jimma city, Ethiopia. One aspect of urban growth posing a threat on sustainable development is poor solid waste management, which results in environmental pollution. The purpose of this study is to evaluate the quantity, composition, sources of waste generated, their current disposal practices, and to recommend appropriate management technologies. The total waste generated daily in Jimma city was ca. 88,000 kg, and the average per capita generation rate was 0.55 ± 0.17 kg/capita/day. Eighty-seven percent of the waste was produced by households and 13% by institutions, and a negligible fraction (0.1%) was generated by street sweepings. During the rainy season, 40% more waste was generated than in the dry season because of the increased availability of agricultural food product. Further analysis showed that biodegradable organic waste constitutes 54% by weight with an average moisture content of 60% that falls within the required limits for composting. The nonbiodegradable components constitute 46% of which 30% of it was nonrecyclable material. Only 25% of the community uses municipal containers for disposal at the selected landfill site. Fifty-one percent of the households disposed their waste in individually chosen spots, whereas 22% burned their waste. Finally 2% of households use private waste collectors. The socioeconomic analysis showed that higher family income and educational status is associated more with private or municipal waste collection and less with the application of backyard or open dumping. These insights into generated waste and management practice in Jimma city allow making suggestions for improved collection, treatment, and disposal methods. A primary conclusion is that the biodegradable waste is a major fraction having suitable properties for recycling. As such an economic benefit can be obtained from

  5. Ozone generation by negative direct current corona discharges in dry air fed coaxial wire-cylinder reactors

    NASA Astrophysics Data System (ADS)

    Yehia, Ashraf; Mizuno, Akira

    2013-05-01

    An analytical study was made in this paper for calculating the ozone generation by negative dc corona discharges. The corona discharges were formed in a coaxial wire-cylinder reactor. The reactor was fed by dry air flowing with constant rates at atmospheric pressure and room temperature, and stressed by a negative dc voltage. The current-voltage characteristics of the negative dc corona discharges formed inside the reactor were measured in parallel with concentration of the generated ozone under different operating conditions. An empirical equation was derived from the experimental results for calculating the ozone concentration generated inside the reactor. The results, that have been recalculated by using the derived equation, have agreed with the experimental results over the whole range of the investigated parameters, except in the saturation range for the ozone concentration. Therefore, the derived equation represents a suitable criterion for expecting the ozone concentration generated by negative dc corona discharges in dry air fed coaxial wire-cylinder reactors under any operating conditions in range of the investigated parameters.

  6. Ozone generation by negative direct current corona discharges in dry air fed coaxial wire-cylinder reactors

    SciTech Connect

    Yehia, Ashraf; Mizuno, Akira

    2013-05-14

    An analytical study was made in this paper for calculating the ozone generation by negative dc corona discharges. The corona discharges were formed in a coaxial wire-cylinder reactor. The reactor was fed by dry air flowing with constant rates at atmospheric pressure and room temperature, and stressed by a negative dc voltage. The current-voltage characteristics of the negative dc corona discharges formed inside the reactor were measured in parallel with concentration of the generated ozone under different operating conditions. An empirical equation was derived from the experimental results for calculating the ozone concentration generated inside the reactor. The results, that have been recalculated by using the derived equation, have agreed with the experimental results over the whole range of the investigated parameters, except in the saturation range for the ozone concentration. Therefore, the derived equation represents a suitable criterion for expecting the ozone concentration generated by negative dc corona discharges in dry air fed coaxial wire-cylinder reactors under any operating conditions in range of the investigated parameters.

  7. Dynamics of the microstructure of current channels and the generation of high-energy electrons in nanosecond discharges in air

    SciTech Connect

    Karelin, V. I.; Trenkin, A. A. Fedoseev, I. G.

    2015-12-15

    The results of the three-dimensional numerical simulation of the dynamics of the microstructure of high-voltage nanosecond discharges in air at atmospheric pressure are presented. It is established that the fast (at a time of ≈10 ns) broadening and significant decrease in the gas concentration in the microchannels occur as a result of the ohmic heating of microchannels with the diameter of 1–30 μm. It was shown that the broadening of microchannels in a nanosecond diffusive discharge provides an increase in the ratio of the electric field strength to the gas concentration in microchannels to values sufficient for the generation highenergy electron beams and X-ray bremsstrahlung in them. Features of the dynamics of the system of microchannels and its effect on the efficiency of the generation of high-energy electrons in discharges developing in the microstructuring regime of the current channels are considered.

  8. From Chemical Gardens to Fuel Cells: Generation of Electrical Potential and Current Across Self-Assembling Iron Mineral Membranes.

    PubMed

    Barge, Laura M; Abedian, Yeghegis; Russell, Michael J; Doloboff, Ivria J; Cartwright, Julyan H E; Kidd, Richard D; Kanik, Isik

    2015-07-06

    We examine the electrochemical gradients that form across chemical garden membranes and investigate how self-assembling, out-of-equilibrium inorganic precipitates-mimicking in some ways those generated in far-from-equilibrium natural systems-can generate electrochemical energy. Measurements of electrical potential and current were made across membranes precipitated both by injection and solution interface methods in iron-sulfide and iron-hydroxide reaction systems. The battery-like nature of chemical gardens was demonstrated by linking multiple experiments in series which produced sufficient electrical energy to light an external light-emitting diode (LED). This work paves the way for determining relevant properties of geological precipitates that may have played a role in hydrothermal redox chemistry at the origin of life, and materials applications that utilize the electrochemical properties of self-organizing chemical systems.

  9. Role of Multicellular Aggregates in Biofilm Formation

    PubMed Central

    Kragh, Kasper N.; Hutchison, Jaime B.; Melaugh, Gavin; Rodesney, Chris; Roberts, Aled E. L.; Irie, Yasuhiko; Jensen, Peter Ø.; Diggle, Stephen P.; Allen, Rosalind J.

    2016-01-01

    ABSTRACT In traditional models of in vitro biofilm development, individual bacterial cells seed a surface, multiply, and mature into multicellular, three-dimensional structures. Much research has been devoted to elucidating the mechanisms governing the initial attachment of single cells to surfaces. However, in natural environments and during infection, bacterial cells tend to clump as multicellular aggregates, and biofilms can also slough off aggregates as a part of the dispersal process. This makes it likely that biofilms are often seeded by aggregates and single cells, yet how these aggregates impact biofilm initiation and development is not known. Here we use a combination of experimental and computational approaches to determine the relative fitness of single cells and preformed aggregates during early development of Pseudomonas aeruginosa biofilms. We find that the relative fitness of aggregates depends markedly on the density of surrounding single cells, i.e., the level of competition for growth resources. When competition between aggregates and single cells is low, an aggregate has a growth disadvantage because the aggregate interior has poor access to growth resources. However, if competition is high, aggregates exhibit higher fitness, because extending vertically above the surface gives cells at the top of aggregates better access to growth resources. Other advantages of seeding by aggregates, such as earlier switching to a biofilm-like phenotype and enhanced resilience toward antibiotics and immune response, may add to this ecological benefit. Our findings suggest that current models of biofilm formation should be reconsidered to incorporate the role of aggregates in biofilm initiation. PMID:27006463

  10. The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes.

    PubMed Central

    DiFrancesco, D

    1991-01-01

    if size in the range -55 to -115 mV. Thus, uncorrected measurements of the instantaneous component and of if may concur to underestimate the role of if in pacemaking. 7. These results lead to the conclusion that in the SA node cells analysed, pacemaker activity is generated with the essential contribution of the hyperpolarization-activated current, if. Numerical computation of SA node cell activity using an extension of the DiFrancesco-Noble model shows that the if-activation hypothesis can account for the presence of spontaneous action potentials and their sensitivity to if changes. PMID:2023118

  11. High-current long-duration uniform electron beam generation in a diode with multicapillary carbon-epoxy cathode

    SciTech Connect

    Queller, T.; Gleizer, J. Z.; Krasik, Ya. E.

    2013-09-28

    The results of reproducibly generating an electron beam with a current density of up to 5 kA/cm{sup 2}, without the cathode-anode gap being shorted by the plasma formed inside the cathode carbon-epoxy capillaries, in a ∼350 kV, ∼600 ns diode, with and without an external guiding magnetic field, are presented. The cathode sustained hundreds of pulses without degradation of its emission properties. Time- and space-resolved emissions of the plasma and spectroscopy analyses were used to determine the cathode plasma's density, temperature, and expansion velocity.

  12. Spontaneous superfluid current generation in the kaon condensed color flavor locked phase at nonzero strange quark mass

    SciTech Connect

    Kryjevski, Andrei

    2008-01-01

    We find that for a large enough strange quark mass, m{sub s}{sup 2}/4{mu}{delta}>2/3(1-0.023) ({mu} is the quark number chemical potential, {delta} is the superconducting gap), the kaon condensed color flavor locked (CFL) phase of asymptotically dense strongly interacting 3 flavor quark matter is unstable with respect to spontaneous generation of currents of Nambu Goldstone bosons due to spontaneous breaking of baryon number symmetry and hypercharge symmetry in the CFLK{sup 0} ground state. The total baryon and hypercharge currents vanish in the ground state. We find that CFLK{sup 0} and the new state are separated by a first order phase transition. The result is derived in the mean field approximation of high density effective theory with electromagnetic interactions turned off.

  13. A HIGH CURRENT, HIGH VOLTAGE SOLID-STATE PULSE GENERATOR FOR THE NIF PLASMA ELECTRODE POCKELS CELL

    SciTech Connect

    Arnold, P A; Barbosa, F; Cook, E G; Hickman, B C; Akana, G L; Brooksby, C A

    2007-07-27

    A high current, high voltage, all solid-state pulse modulator has been developed for use in the Plasma Electrode Pockels Cell (PEPC) subsystem in the National Ignition Facility. The MOSFET-switched pulse generator, designed to be a more capable plug-in replacement for the thyratron-switched units currently deployed in NIF, offers unprecedented capabilities including burst-mode operation, pulse width agility and a steady-state pulse repetition frequency exceeding 1 Hz. Capable of delivering requisite fast risetime, 17 kV flattop pulses into a 6 {Omega} load, the pulser employs a modular architecture characteristic of the inductive adder technology, pioneered at LLNL for use in acceleration applications, which keeps primary voltages low (and well within the capabilities of existing FET technology), reduces fabrication costs and is amenable to rapid assembly and quick field repairs.

  14. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  15. Ion and electron dynamics generating the Hall current in the exhaust far downstream of the reconnection x-line

    SciTech Connect

    Fujimoto, Keizo; Takamoto, Makoto

    2016-01-15

    We have investigated the ion and electron dynamics generating the Hall current in the reconnection exhaust far downstream of the x-line where the exhaust width is much larger than the ion gyro-radius. A large-scale particle-in-cell simulation shows that most ions are accelerated through the Speiser-type motion in the current sheet formed at the center of the exhaust. The transition layers formed at the exhaust boundary are not identified as slow mode shocks. (The layers satisfy mostly the Rankine-Hugoniot conditions for a slow mode shock, but the energy conversion hardly occurs there.) We find that the ion drift velocity is modified around the layer due to a finite Larmor radius effect. As a result, the ions are accumulated in the downstream side of the layer, so that collimated ion jets are generated. The electrons experience two steps of acceleration in the exhaust. The first is a parallel acceleration due to the out-of-plane electric field E{sub y} which has a parallel component in most area of the exhaust. The second is a perpendicular acceleration due to E{sub y} at the center of the current sheet and the motion is converted to the parallel direction. Because of the second acceleration, the electron outflow velocity becomes almost uniform over the exhaust. The difference in the outflow profile between the ions and electrons results in the Hall current in large area of the exhaust. The present study demonstrates the importance of the kinetic treatments for collisionless magnetic reconnection even far downstream from the x-line.

  16. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24 Aggregation... same floodplain, and are currently under review by the Department (or by a grant recipient subject...

  17. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24 Aggregation... same floodplain, and are currently under review by the Department (or by a grant recipient subject...

  18. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24 Aggregation... same floodplain, and are currently under review by the Department (or by a grant recipient subject...

  19. 24 CFR 55.24 - Aggregation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.24 Aggregation... same floodplain, and are currently under review by the Department (or by a grant recipient subject...

  20. On mean type aggregation.

    PubMed

    Yager, R R

    1996-01-01

    We introduce and define the concept of mean aggregation of a collection of n numbers. We point out that the lack of associativity of this operation compounds the problem of the extending mean of n numbers to n+1 numbers. The closely related concepts of self identity and the centering property are introduced as one imperative for extending mean aggregation operators. The problem of weighted mean aggregation is studied. A new concept of prioritized mean aggregation is then introduced. We next show that the technique of selecting an element based upon the performance of a random experiment can be considered as a mean aggregation operation.

  1. Archean Earth Atmosphere Fractal Haze Aggregates: Light Scattering Calculations and the Faint Young Sun Paradox

    NASA Astrophysics Data System (ADS)

    Boness, D. A.; Terrell-Martinez, B.

    2010-12-01

    As part of an ongoing undergraduate research project of light scattering calculations involving fractal carbonaceous soot aggregates relevant to current anthropogenic and natural sources in Earth's atmosphere, we have read with interest a recent paper [E.T. Wolf and O.B Toon,Science 328, 1266 (2010)] claiming that the Faint Young Sun paradox discussed four decades ago by Carl Sagan and others can be resolved without invoking heavy CO2 concentrations as a greenhouse gas warming the early Earth enough to sustain liquid water and hence allow the origin of life. Wolf and Toon report that a Titan-like Archean Earth haze, with a fractal haze aggregate nature due to nitrogen-methane photochemistry at high altitudes, should block enough UV light to protect the warming greenhouse gas NH3 while allowing enough visible light to reach the surface of the Earth. To test this hypothesis, we have employed a rigorous T-Matrix arbitrary-particle light scattering technique, to avoid the simplifications inherent in Mie-sphere scattering, on haze fractal aggregates at UV and visible wavelenths of incident light. We generate these model aggregates using diffusion-limited cluster aggregation (DLCA) algorithms, which much more closely fit actual haze fractal aggregates than do diffusion-limited aggregation (DLA) algorithms.

  2. Space-charge effects in ultra-high current electron bunches generated by laser-plasma accelerators

    SciTech Connect

    Grinner, F. J.; Schroeder, C. B.; Maier, A. R.; Becker, S.; Mikhailova, J. M.

    2009-02-11

    Recent advances in laser-plasma accelerators, including the generation of GeV-scale electron bunches, enable applications such as driving a compact free-electron-laser (FEL). Significant reduction in size of the FEL is facilitated by the expected ultra-high peak beam currents (10-100 kA) generated in laser-plasma accelerators. At low electron energies such peak currents are expected to cause space-charge effects such as bunch expansion and induced energy variations along the bunch, potentially hindering the FEL process. In this paper we discuss a self-consistent approach to modeling space-charge effects for the regime of laser-plasma-accelerated ultra-compact electron bunches at low or moderate energies. Analytical treatments are considered as well as point-to-point particle simulations, including the beam transport from the laser-plasma accelerator through focusing devices and the undulator. In contradiction to non-self-consistent analyses (i.e., neglecting bunch evolution), which predict a linearly growing energy chirp, we have found the energy chirp reaches a maximum and decreases thereafter. The impact of the space-charge induced chirp on FEL performance is discussed and possible solutions are presented.

  3. Stabilization of species coexistence in spatial models through the aggregation-segregation effect generated by local dispersal and nonspecific local interactions.

    PubMed

    Detto, Matteo; Muller-Landau, Helene C

    2016-12-01

    Spatial interactions are widely acknowledged to play a significant role in sustaining diversity in ecological communities. However, theoretical work on this topic has focused on how spatial processes affect coexistence of species that differ in their strategies, with less attention to how spatial processes matter when competitors are equivalent. Furthermore, though it is recognized that models with local dispersal and local competition may sustain higher diversities of equivalent competitors than models in which these are not both localized, there is debate as to whether this reflects merely equalizing effects or whether there is also a stabilizing component. In this study, we explore how dispersal limitation and nonspecific local competition influence the outcome of species coexistence in communities driven by stochastic drift. We demonstrate that space alone acts as a stabilizing factor in a continuous space model with local dispersal and competition, as individuals of rare species on average experience lower total neighborhood densities, causing per capita reproductive rates to decrease systematically with increasing abundance. These effects prolong time to extinction in a closed system and enhance species diversity in an open system with constant immigration. Fundamentally, these stabilizing effects are obtained when dispersal limitation interacts with local competition to generate fluctuations in population growth rates. Thus this effect can be considered a fluctuating mechanism similar to spatial or temporal storage effects, but generated purely endogenously without requiring any exogenous environmental variability or species dissimilarities.

  4. Experimental aggregation of volcanic ash: the role of liquid bonding

    NASA Astrophysics Data System (ADS)

    Mueller, S.; Kueppers, U.; Jacob, M.; Ayris, P. M.; Dingwell, D. B.

    2015-12-01

    Explosive volcanic eruptions may release vast quantities of ash. Because of its size, it has the greatest dispersal potential and can be distributed globally. Ash may pose severe risks for 1) air traffic, 2) human and animal health, 3) agriculture and 4) infrastructure. Such ash particles can however cluster and form ash aggregates that range in size from millimeters to centimeters. During their growth, weight and aerodynamic properties change. This leads to significantly changed transport and settling behavior. The physico-chemical processes involved in aggregation are quantitatively poorly constrained. We have performed laboratory ash aggregation experiments using the ProCell Lab System® of Glatt Ingenieurtechnik GmbH. Solid particles are set into motion in a fluidized bed over a range of well-controlled boundary conditions (e.g., air flow rate, gas temperature, humidity, liquid composition). In this manner we simulate the variable gas-particle flow conditions expected in eruption plumes and pyroclastic density currents. We have used 1) soda-lime glass beads as an analogue material and 2) natural volcanic ash from Laacher See Volcano (Germany). In order to influence form, size, stability and the production rate of aggregates, a range of experimental conditions (e.g., particle concentration, degree of turbulence, temperature and moisture in the process chamber and the composition of the liquid phase) have been employed. We have successfully reproduced several features of natural ash aggregates, including round, internally structured ash pellets up to 3 mm in diameter. These experimental results help to constrain the boundary conditions required for the generation of spherical, internally-structured ash aggregates that survive deposition and are preserved in the volcanological record. These results should also serve as input parameters for models of ash transport and ash mass distribution.

  5. Experimental volcanic ash aggregation: Internal structuring of accretionary lapilli and the role of liquid bonding

    NASA Astrophysics Data System (ADS)

    Mueller, Sebastian B.; Kueppers, Ulrich; Ayris, Paul M.; Jacob, Michael; Dingwell, Donald B.

    2016-01-01

    Explosive volcanic eruptions can release vast quantities of pyroclastic material into Earth's atmosphere, including volcanic ash, particles with diameters less than two millimeters. Ash particles can cluster together to form aggregates, in some cases reaching up to several centimeters in size. Aggregation alters ash transport and settling behavior compared to un-aggregated particles, influencing ash distribution and deposit stratigraphy. Accretionary lapilli, the most commonly preserved type of aggregates within the geologic record, can exhibit complex internal stratigraphy. The processes involved in the formation and preservation of these aggregates remain poorly constrained quantitatively. In this study, we simulate the variable gas-particle flow conditions which may be encountered within eruption plumes and pyroclastic density currents via laboratory experiments using the ProCell Lab System® of Glatt Ingenieurtechnik GmbH. In this apparatus, solid particles are set into motion in a fluidized bed over a range of well-controlled boundary conditions (particle concentration, air flow rate, gas temperature, humidity, liquid composition). Experiments were conducted with soda-lime glass beads and natural volcanic ash particles under a range of experimental conditions. Both glass beads and volcanic ash exhibited the capacity for aggregation, but stable aggregates could only be produced when materials were coated with high but volcanically-relevant concentrations of NaCl. The growth and structure of aggregates was dependent on the initial granulometry, while the rate of aggregate formation increased exponentially with increasing relative humidity (12-45% RH), before overwetting promoted mud droplet formation. Notably, by use of a broad granulometry, we generated spherical, internally structured aggregates similar to some accretionary pellets found in volcanic deposits. Adaptation of a powder-technology model offers an explanation for the origin of natural accretionary

  6. Single molecule force spectroscopy of asphaltene aggregates.

    PubMed

    Long, Jun; Xu, Zhenghe; Masliyah, Jacob H

    2007-05-22

    Asphaltene aggregation and deposition cause severe problems in nearly all phases of petroleum processing. To resolve those problems, understanding the aggregation mechanisms is a prerequisite and has attracted the interest of a great number of investigators. However, to date, the nature and extent of asphaltene aggregation remain widely debated. In the present study, we attempt to investigate asphaltene aggregation from a completely new perspective. The technique of single molecule force spectroscopy (SMFS) was used to investigate the response of single asphaltene aggregates under an external pulling force. Force curves representing the stretching of single asphaltene aggregates were obtained in simple electrolyte solutions (KCl and calcium) and organic solvents (toluene and heptane). These force curves were well-fitted by the modified worm-like chain model, indicating that those asphaltene aggregates acted like long-chain polymers under pulling by an external force. It was found that lower solution pH values and the presence of divalent cations resulted in a lower bending rigidity of the formed aggregates. The information retrieved from the force curves suggests that asphaltene molecules with a structure featuring small aromatic clusters connected by aliphatic chains do exist and that asphaltene aggregation could occur through a linear polymerization mechanism. The current study extends the application scope of SMFS.

  7. RBC aggregation: laboratory data and models.

    PubMed

    Meiselman, H J; Neu, B; Rampling, M W; Baskurt, O K

    2007-01-01

    The reversible aggregation of red blood cells (RBC) into linear and three-dimensional structures continues to be of basic science and clinical interest: RBC aggregation affects low shear blood viscosity and microvascular flow dynamics, and can be markedly enhanced in several clinical states. Until fairly recently, most research efforts were focused on relations between suspending medium composition (i.e., protein levels, polymer type and concentration) and aggregate formation. However, there is now an increasing amount of experimental evidence indicating that RBC cellular properties can markedly affect aggregation, with the term "RBC aggregability" coined to describe the cell's intrinsic tendency to aggregate. Variations of aggregability can be large, with some changes of aggregation substantially greater than those resulting from pathologic states. The present review provides a brief overview of this topic, and includes such areas as donor-to-donor variations, polymer-plasma correlations, effects of RBC age, effects of enzymatic treatment, and current developments related to the mechanisms involved in RBC aggregation.

  8. A high current pulsed power generator CQ-3-MMAF with co-axial cable transmitting energy for material dynamics experiments

    NASA Astrophysics Data System (ADS)

    Wang, Guiji; Chen, Xuemiao; Cai, Jintao; Zhang, Xuping; Chong, Tao; Luo, Binqiang; Zhao, Jianheng; Sun, Chengwei; Tan, Fuli; Liu, Cangli; Wu, Gang

    2016-06-01

    A high current pulsed power generator CQ-3-MMAF (Multi-Modules Assembly Facility, MMAF) was developed for material dynamics experiments under ramp wave and shock loadings at the Institute of Fluid Physics (IFP), which can deliver 3 MA peak current to a strip-line load. The rise time of the current is 470 ns (10%-90%). Different from the previous CQ-4 at IFP, the CQ-3-MMAF energy is transmitted by hundreds of co-axial high voltage cables with a low impedance of 18.6 mΩ and low loss, and then hundreds of cables are reduced and converted to tens of cables into a vacuum chamber by a cable connector, and connected with a pair of parallel metallic plates insulated by Kapton films. It is composed of 32 capacitor and switch modules in parallel. The electrical parameters in short circuit are with a capacitance of 19.2 μF, an inductance of 11.7 nH, a resistance of 4.3 mΩ, and working charging voltage of 60 kV-90 kV. It can be run safely and stable when charged from 60 kV to 90 kV. The vacuum of loading chamber can be up to 10-2 Pa, and the current waveforms can be shaped by discharging in time sequences of four groups of capacitor and switch modules. CQ-3-MMAF is an adaptive machine with lower maintenance because of its modularization design. The COMSOL Multi-physics® code is used to optimize the structure of some key components and calculate their structural inductance for designs, such as gas switches and cable connectors. Some ramp wave loading experiments were conducted to check and examine the performances of CQ-3-MMAF. Two copper flyer plates were accelerated to about 3.5 km/s in one shot when the working voltage was charged to 70 kV. The velocity histories agree very well. The dynamic experiments of some polymer bonded explosives and phase transition of tin under ramp wave loadings were also conducted. The experimental data show that CQ-3-MMAF can be used to do material dynamics experiments in high rate and low cost shots. Based on this design concept, the peak

  9. A high current pulsed power generator CQ-3-MMAF with co-axial cable transmitting energy for material dynamics experiments.

    PubMed

    Wang, Guiji; Chen, Xuemiao; Cai, Jintao; Zhang, Xuping; Chong, Tao; Luo, Binqiang; Zhao, Jianheng; Sun, Chengwei; Tan, Fuli; Liu, Cangli; Wu, Gang

    2016-06-01

    A high current pulsed power generator CQ-3-MMAF (Multi-Modules Assembly Facility, MMAF) was developed for material dynamics experiments under ramp wave and shock loadings at the Institute of Fluid Physics (IFP), which can deliver 3 MA peak current to a strip-line load. The rise time of the current is 470 ns (10%-90%). Different from the previous CQ-4 at IFP, the CQ-3-MMAF energy is transmitted by hundreds of co-axial high voltage cables with a low impedance of 18.6 mΩ and low loss, and then hundreds of cables are reduced and converted to tens of cables into a vacuum chamber by a cable connector, and connected with a pair of parallel metallic plates insulated by Kapton films. It is composed of 32 capacitor and switch modules in parallel. The electrical parameters in short circuit are with a capacitance of 19.2 μF, an inductance of 11.7 nH, a resistance of 4.3 mΩ, and working charging voltage of 60 kV-90 kV. It can be run safely and stable when charged from 60 kV to 90 kV. The vacuum of loading chamber can be up to 10(-2) Pa, and the current waveforms can be shaped by discharging in time sequences of four groups of capacitor and switch modules. CQ-3-MMAF is an adaptive machine with lower maintenance because of its modularization design. The COMSOL Multi-physics® code is used to optimize the structure of some key components and calculate their structural inductance for designs, such as gas switches and cable connectors. Some ramp wave loading experiments were conducted to check and examine the performances of CQ-3-MMAF. Two copper flyer plates were accelerated to about 3.5 km/s in one shot when the working voltage was charged to 70 kV. The velocity histories agree very well. The dynamic experiments of some polymer bonded explosives and phase transition of tin under ramp wave loadings were also conducted. The experimental data show that CQ-3-MMAF can be used to do material dynamics experiments in high rate and low cost shots. Based on this design concept, the peak

  10. Internal heating of lithium-ion batteries using alternating current based on the heat generation model in frequency domain

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbo; Ge, Hao; Li, Zhe; Ding, Zhanming

    2015-01-01

    This study develops a method to internally preheat lithium-ion batteries at low temperatures with sinusoidal alternating current (AC). A heat generation rate model in frequency domain is developed based on the equivalent electrical circuit. Using this model as the source term, a lumped energy conservation model is adopted to predict the temperature rise. These models are validated against the experimental results of preheating an 18650 cell at different thermal insulation conditions. The effects of current amplitude and frequency on the heating rate are illustrated with a series of simulated contours of heating time. These contours indicate that the heating rate increases with higher amplitude, lower frequency and better thermal insulation. The cell subjected to an alternating current with an amplitude of 7 A (2.25 C) and a frequency of 1 Hz, under a calibrated heat transfer coefficient of 15.9 W m-2 K-1, can be heated from -20 °C to 5 °C within 15 min and the temperature distribution remains essentially uniform. No capacity loss is found after repeated AC preheating tests, indicating this method incurs little damage to the battery health. These models are computationally-efficient and can be used in real time to control the preheating devices in electric vehicles.

  11. Differential geometry based model for eddy current inspection of U-bend sections in steam generator tubes

    NASA Astrophysics Data System (ADS)

    Mukherjee, Saptarshi; Rosell, Anders; Udpa, Lalita; Udpa, Satish; Tamburrino, Antonello

    2017-02-01

    The modeling of U-Bend segment in steam generator tubes for predicting eddy current probe signals from cracks, wear and pitting in this region poses challenges and is non-trivial. Meshing the geometry in the cartesian coordinate system might require a large number of elements to model the U-bend region. Also, since the lift-off distance between the probe and tube wall is usually very small, a very fine mesh is required near the probe region to accurately describe the eddy current field. This paper presents a U-bend model using differential geometry principles that exploit the result that Maxwell's equations are covariant with respect to changes of coordinates and independent of metrics. The equations remain unaltered in their form, regardless of the choice of the coordinates system, provided the field quantities are represented in the proper covariant and contravariant form. The complex shapes are mapped into simple straight sections, while small lift-off is mapped to larger values, thus reducing the intrinsic dimension of the mesh and stiffness matrix. In this contribution, the numerical implementation of the above approach will be discussed with regard to field and current distributions within the U-bend tube wall. For the sake of simplicity, a two dimensional test case will be considered. The approach is evaluated in terms of efficiency and accuracy by comparing the results with that obtained using a conventional FE model in cartesian coordinates.

  12. Three-coil inductively coupled plasma (ICP) source with individually controlled coil currents supplied from a single power generator

    NASA Astrophysics Data System (ADS)

    Dorf, Leonid; Rauf, Shahid; Liu, Jonathan; Kenney, Jason; Lane, Steven; Nguyen, Andrew; Ramaswamy, Kartik; Collins, Ken

    2013-09-01

    As requirements on plasma uniformity get more stringent in the semiconductor industry, an ICP source with 3 coils becomes warranted. Designing a power distribution/50 Ω-tuning network (PDN) that delivers the power from a single generator to 3 coils is complicated, due to inductive coupling between the coils, and between coils and plasma. Our PDN comprises several capacitors, including 2 variable ones, C1,2, connected in parallel to 2 coils. A set of equations for coils/plasma currents was solved over a wide parameter space to determine practical values/ranges for all capacitors. It was shown that by moving along a pre-determined programming path in C1,2 space, one can attain various coil current ratios (CCR) without crossing resonance curves. The latter causes coil current reversal, which may result in plasma instabilities and affect uniformity. Based on modeling results, the PDN was built and tested using a specially made 3-coil source. A wide range of CCR was achieved by varying C1,2, including maxima or minima in any 2 coils. With slight adjustments (to account for parasitics and actual plasma coupling), the model correctly predicted experimentally observed CCR for each tested C1,2 pair. Likewise, the theoretical resonance structure was reproduced experimentally with good agreement.

  13. Functional and Structural Effects of Amyloid-β Aggregate on Xenopus laevis Oocytes

    PubMed Central

    Parodi, Jorge; la Paz, Lenin Ochoa-de; Miledi, Ricardo; Martínez-Torres, Ataúlfo

    2012-01-01

    Xenopus laevis oocytes exposed to amyloid-β aggregate generated oscillatory electric activity (blips) that was recorded by two-microelectrode voltage-clamp. The cells exhibited a series of “spontaneous” blips ranging in amplitude from 3.8 ± 0.9 nA at the beginning of the recordings to 6.8 ± 1.7 nA after 15 min of exposure to 1 μM aggregate. These blips were similar in amplitude to those induced by the channel-forming antimicrobial agents amphotericin B (7.8 ± 1.2 nA) and gramicidin (6.3 ± 1.1 nA). The amyloid aggregate-induced currents were abolished when extracellular Ca2+ was removed from the bathing solution, suggesting a central role for this cation in generating the spontaneous electric activity. The amyloid aggregate also affected the Ca2+-dependent Cl− currents of oocytes, as shown by increased amplitude of the transient-outward chloride current (Tout) and the serum-activated, oscillatory Cl− currents. Electron microcopy revealed that amyloid aggregate induced the dissociation of the follicular cells that surround the oocyte, thus leading to a failure in the electro-chemical communication between these cells. This was also evidenced by the suppression of the oscillatory Ca2+-dependent ATP-currents, which require proper coupling between oocytes and the follicular cell layer. These observations, made using the X. laevis oocytes as a versatile experimental model, may help to understand the effects of amyloid aggregate on cellular communication. PMID:23104436

  14. 17 CFR 5.8 - Aggregate retail forex assets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... merchant may not include aggregate retail forex assets as current assets or otherwise record any property... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Aggregate retail forex assets... FOREIGN CURRENCY TRANSACTIONS § 5.8 Aggregate retail forex assets. (a) Each retail foreign exchange...

  15. Eddy-current inspection for steam generator tubing program. Annual progress report for period ending December 31, 1979

    SciTech Connect

    Dodd, C.V.; Deeds, W.E.; McClung, R.W.

    1980-07-01

    Eddy-current methods provide the best in-service inspection of steam generator tubing, but present techniques can produce ambiguity because of the many independent variables that affect the signals. The current development program has used mathematical models and developed or modified computer programs to design optimum probes, instrumentation, and techniques for multifrequency, multiproperty examinations. Interactive calculations and experimental measurements have been made with the use of modular eddy-current instrumentation and a minicomputer. These establish the coefficients for the complex equations that define the values of the desired properties (and the attainable accuracy) despite changes in other significant variables. The computer programs for calculating the accuracy with which various properties can be measured indicate that the tubing wall thickness and the defect size can be measured much more accurately than is currently required, even when other properties are varying. Our experimental measurements have confirmed these results, although more testing is needed for all the different combinations of cases and different types of defects. To facilitate the extensive laboratory scanning of the matrix of specimens that are necessary to develop algorithms for detection and analysis for all the possible combinations of positions of flaws, tube supports, and probe coils, we have designed, constructed, and begun operation of a computer-controlled automatic positioner. We have demonstrated the ability to overcome the large signals produced by the edge of the tube supports. An advanced microcomputer has been designed, constructed, and installed in the instrumentation to control the examination and provide real-time calculations of the desired properties for display recording during the scanning of the tube.

  16. Impact of Particle Aggregation on Nanoparticle Reactivity

    NASA Astrophysics Data System (ADS)

    Jassby, David

    2011-12-01

    nanoparticle that photoluminesces after exposure to UV; TiO2 and ZnO nanoparticles---photocatalytic nanoparticles that generate reactive oxygen species upon UV irradition; and, fullerene nanoparticles used in the filtration experiments, selected for their potential use, small size, and surface chemistry. Our primary methods used to characterize particle and aggregate characteristics include dynamic light scattering used to describe particle size, static light scattering used to characterize aggregate structure (fractal dimension), transmission electron microscopy used to verify primary particle sizes, and electrophoretic mobility measurements to evaluate suspension stability. The reactive property of ZnS that was measured as a function of aggregation was photoluminescence, which was measured using a spectrofluorometer. The reactive property of TiO2 and ZnO that was studied was their ability to generate hydroxyl radicals; these were measured by employing a fluorescent probe that becomes luminescent upon interaction with the hydroxyl radical. To detect the presence of fullerene nanoparticles and calculate removal efficiencies, we used total organic carbon measurements. Additionally, we used UV-vis spectroscopy to approximate the impact of particle shadowing in TiO2 and ZnO aggregates, and Fourier transformed infrared spectroscopy to determine how different electrolytes interact with fullerene surface groups. Our findings indicate that the impact of aggregation on nanoparticle reactivity is material specific. ZnS nanoparticles exhibit a 2-fold increase in band-edge photoluminescence alongside a significant decrease in defect-site photoluminescence. This is attributed to aggregate size-dependent surface tension. Additionally, we used photoluminescence measurements to develop a new method for calculating the critical coagulation concentration of a nanoparticle suspension. The ability of both TiO2 and ZnO to generate hydroxyl radicals was significantly hampered by aggregation. The

  17. Critical current density and ac harmonic voltage generation in YBaCuO thin films by the screening technique

    NASA Astrophysics Data System (ADS)

    Pérez-López, Israel O.; Gamboa, Fidel; Sosa, Víctor

    2010-12-01

    The temperature and field dependence of harmonics in voltage Vn=Vn‧-iVn″ using the screening technique have been measured for YBaCuO superconducting thin films. Using the Sun model we obtained the curves for the temperature-dependent critical current density Jc(T). In addition, we applied the criterion proposed by Acosta et al. to compute Jc(T). Also, we made used of the empirical law Jc∝(1-T/Tc)n as an input in our calculations to reproduce experimental harmonic generation up to the fifth harmonic. We found that most models fit well the fundamental voltage but higher harmonics are poorly reproduced. Such behavior suggests the idea that higher harmonics contain information concerning complex processes like flux creep or thermally assisted flux flow.

  18. Thermal generation of spin current in epitaxial CoFe{sub 2}O{sub 4} thin films

    SciTech Connect

    Guo, Er-Jia E-mail: klaeui@uni-mainz.de; Herklotz, Andreas; Kehlberger, Andreas; Cramer, Joel; Jakob, Gerhard; Kläui, Mathias E-mail: klaeui@uni-mainz.de

    2016-01-11

    The longitudinal spin Seebeck effect (LSSE) has been investigated in high-quality epitaxial CoFe{sub 2}O{sub 4} (CFO) thin films. The thermally excited spin currents in the CFO films are electrically detected in adjacent Pt layers due to the inverse spin Hall effect. The LSSE signal exhibits a linear increase with increasing temperature gradient, yielding a LSSE coefficient of ∼100 nV/K at room temperature. The temperature dependence of the LSSE is investigated from room temperature down to 30 K, showing a significant reduction at low temperatures, revealing that the total amount of thermally generated magnons decreases. Furthermore, we demonstrate that the spin Seebeck effect is an effective tool to study the magnetic anisotropy induced by epitaxial strain, especially in ultrathin films with low magnetic moments.

  19. Morphological properties of atmospheric aerosol aggregates

    PubMed Central

    Xiong, C.; Friedlander, S. K.

    2001-01-01

    Ultrafine particles (smaller than about 0.1 μm) are often emitted from combustion and other high-temperature processes in the form of fractal-like aggregates composed of solid nanoparticles. Results of a study of atmospheric aggregates are reported. Particles were collected on transmission electron microscope grids fitted on the last two stages of a single-jet eight-stage low-pressure impactor for periods of a few minutes. Photomicrographs of transmission electron microscope grids from the impactor stages were analyzed to obtain the fractal dimension (Df) and prefactor (A) for aggregates. Df increased from near 1 to above 2 as the number of primary particles making up the aggregates increased from 10 to 180. Total particle concentrations in size ranges roughly equivalent to the low-pressure impactor stages were measured with a mobility analyzer and condensation particle counter. In one set of measurements, the fraction of the particles present as aggregates was about 60% for particles with aerodynamic diameters between 50 and 75 nm and 34% for the range 75 to 120 nm. The total aggregate concentration in the 50- to 120-nm size range was about 400 ml−1. The primary particles that make up atmospheric aggregates are more polydisperse than soot aggregates generated from a single laboratory source, an ethane/oxygen flame. Most measurements were made in the Los Angeles area, where the aggregates may represent a signature for diesel emissions. Rural aggregate concentrations in the size range 50 to 120 nm were less than 1% of the concentrations at urban sites. The data will permit better estimates of atmospheric aggregate residence times, transport, and deposition in the lung, optical extinction, and heterogenous nucleation. PMID:11592995

  20. Morphological properties of atmospheric aerosol aggregates.

    PubMed

    Xiong, C; Friedlander, S K

    2001-10-09

    Ultrafine particles (smaller than about 0.1 microm) are often emitted from combustion and other high-temperature processes in the form of fractal-like aggregates composed of solid nanoparticles. Results of a study of atmospheric aggregates are reported. Particles were collected on transmission electron microscope grids fitted on the last two stages of a single-jet eight-stage low-pressure impactor for periods of a few minutes. Photomicrographs of transmission electron microscope grids from the impactor stages were analyzed to obtain the fractal dimension (D(f)) and prefactor (A) for aggregates. D(f) increased from near 1 to above 2 as the number of primary particles making up the aggregates increased from 10 to 180. Total particle concentrations in size ranges roughly equivalent to the low-pressure impactor stages were measured with a mobility analyzer and condensation particle counter. In one set of measurements, the fraction of the particles present as aggregates was about 60% for particles with aerodynamic diameters between 50 and 75 nm and 34% for the range 75 to 120 nm. The total aggregate concentration in the 50- to 120-nm size range was about 400 ml(-1). The primary particles that make up atmospheric aggregates are more polydisperse than soot aggregates generated from a single laboratory source, an ethane/oxygen flame. Most measurements were made in the Los Angeles area, where the aggregates may represent a signature for diesel emissions. Rural aggregate concentrations in the size range 50 to 120 nm were less than 1% of the concentrations at urban sites. The data will permit better estimates of atmospheric aggregate residence times, transport, and deposition in the lung, optical extinction, and heterogeneous nucleation.

  1. A pulsed eddy current probe for inspection of support plates from within Alloy-800 steam generator tubes

    NASA Astrophysics Data System (ADS)

    Krause, T. W.; Babbar, V. K.; Underhill, P. R.

    2014-02-01

    Support plate degradation and fouling in nuclear steam generators (SGs) can lead to SG tube corrosion and loss of efficiency. Inspection and monitoring of these conditions can be integrated with preventive maintenance programs, thereby advancing station-life management processes. A prototype pulsed eddy current (PEC) probe, targeting inspection issues associated with SG tubes in SS410 tube support plate structures, has been developed using commercial finite element (FE) software. FE modeling was used to identify appropriate driver and pickup coil configurations for optimum sensitivity to changes in gap and offset for Alloy-800 SG tubes passing through 25 mm thick SS410 support plates. Experimental measurements using a probe that was manufactured based on the modeled configuration, were used to confirm the sensitivity of differential PEC signals to changes in relative position of the tube within the tube support plate holes. Models investigated the effect of shift and tilt of tube with respect to hole centers. Near hole centers and for small shifts, modeled signal amplitudes from the differentially connected coil pairs were observed to change linearly with tube shift. This was in agreement with experimentally measured TEC coil response. The work paves the way for development of a system targeting the inspection and evaluation of support plate structures in steam generators.

  2. The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?

    PubMed

    Woods, Dori C; Tilly, Jonathan L

    2012-07-01

    Stem cell-based strategies for ovarian regeneration and oocyte production have been proposed as future clinical therapies for treating infertility in women. However, utilization of embryonic stem cells or induced pluripotent stem cells to produce oocytes has had limited success in vitro. A recent report of the isolation and characterization of endogenous oocyte-producing or oogonial stem cells (OSCs) from ovaries of reproductive age women describes the first stable and pure human female germ cell culture model in which a subset of cells appear to initiate and complete meiosis. In addition, purified human OSCs introduced into adult human ovarian cortical tissue generate oocytes that arrest at the diplotene stage of meiosis and successfully recruit granulosa cells to form new primordial follicles. This overview examines the current landscape of in vitro and in vivo gametogenesis from stem cells, with emphasis on generation of human oocytes. Future research objectives for this area of work, as well as potential clinical applications involving the use of human OSCs, are discussed.

  3. A pulsed eddy current probe for inspection of support plates from within Alloy-800 steam generator tubes

    SciTech Connect

    Krause, T. W.; Babbar, V. K.; Underhill, P. R.

    2014-02-18

    Support plate degradation and fouling in nuclear steam generators (SGs) can lead to SG tube corrosion and loss of efficiency. Inspection and monitoring of these conditions can be integrated with preventive maintenance programs, thereby advancing station-life management processes. A prototype pulsed eddy current (PEC) probe, targeting inspection issues associated with SG tubes in SS410 tube support plate structures, has been developed using commercial finite element (FE) software. FE modeling was used to identify appropriate driver and pickup coil configurations for optimum sensitivity to changes in gap and offset for Alloy-800 SG tubes passing through 25 mm thick SS410 support plates. Experimental measurements using a probe that was manufactured based on the modeled configuration, were used to confirm the sensitivity of differential PEC signals to changes in relative position of the tube within the tube support plate holes. Models investigated the effect of shift and tilt of tube with respect to hole centers. Near hole centers and for small shifts, modeled signal amplitudes from the differentially connected coil pairs were observed to change linearly with tube shift. This was in agreement with experimentally measured TEC coil response. The work paves the way for development of a system targeting the inspection and evaluation of support plate structures in steam generators.

  4. Formation of a Micropinch and Generation of Multiply Charged Ions at the Front of a Current-Carrying Plasma Jet

    SciTech Connect

    Zverev, E.A.; Krasov, V.I.; Krinberg, I.A.; Papernyi, V.L.

    2005-10-15

    The formation of a neck in the cathode plasma jet in the initial stage of a low-voltage vacuum spark is investigated experimentally and theoretically. X-ray bursts corresponding to an electron temperature of 150-300 eV are detected. With the use of a pinhole camera, it is found that an emitting region less than 1 mm in size is located near the cathode. The free expansion of a current-carrying cathode plasma jet with a current growing in accordance with the experimentally observed time dependence is simulated using a hydrodynamic model. It is shown that the neck forms at the front of the plasma jet due to the plasma compression by the magnetic self-field. In the constriction region, the plasma is rapidly heated and multiply charged ions are generated. The calculated spatial and temporal variations in the electron temperature and average ion charge are close to the measured dependences over a wide range of the discharge parameters.

  5. Generation of dual pulses of the runaway electron beam current during the subnanosecond breakdown of atomic and molecular gases

    NASA Astrophysics Data System (ADS)

    Tarasenko, V. F.; Sorokin, D. A.; Lomaev, M. I.

    2016-10-01

    With a diaphragm placed behind the anode foil, dual runaway electron beams have been provided in helium, hydrogen, nitrogen, and air under a pressure of several torrs to several dozen torrs and a high-voltage pulse amplitude of about 250 kV. These beams consist of two pulses with commensurable amplitudes with a time interval between them of several dozen picoseconds to several hundred picoseconds. It has been shown that the breakdown of the interelectrode gap at pressures from several torrs to several dozen torrs may occur in different regimes and dual pulses of the electron beam current are registered when the initial current through the gap is below 1 kA. It has been found that a supershort avalanche electron beam that consists of one pulse is generated when the delay of breakdown equals several hundred picoseconds. It has been shown that, when the gas pressure reaches several hundred Torr, including atmospheric pressure, the runaway electrons are detected behind the foil after the termination of the supershort avalanche electron beam pulse.

  6. Aggregations in Flatworms.

    ERIC Educational Resources Information Center

    Liffen, C. L.; Hunter, M.

    1980-01-01

    Described is a school project to investigate aggregations in flatworms which may be influenced by light intensity, temperature, and some form of chemical stimulus released by already aggregating flatworms. Such investigations could be adopted to suit many educational levels of science laboratory activities. (DS)

  7. Unbonded Aggregate Surface Roads

    DTIC Science & Technology

    2006-12-01

    are sufficiently angular and rough in texture, thus ensuring mixture stability. A popular asphalt mixture design method called Superpave Level 1...would not pass either of the Superpave aggregate requirements. Table 18 Additional Characteristics for the Fine Fraction Abbreviated Common Name...CBR values when compacted wet of optimum. This is likely attributable to their relatively high permeabilities . For soaked CBR tests, the aggregates

  8. Classification and Characterization of Therapeutic Antibody Aggregates

    PubMed Central

    Joubert, Marisa K.; Luo, Quanzhou; Nashed-Samuel, Yasser; Wypych, Jette; Narhi, Linda O.

    2011-01-01

    A host of diverse stress techniques was applied to a monoclonal antibody (IgG2) to yield protein particles with varying attributes and morphologies. Aggregated solutions were evaluated for percent aggregation, particle counts, size distribution, morphology, changes in secondary and tertiary structure, surface hydrophobicity, metal content, and reversibility. Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, J. (2011) J. Biol. Chem. 286, 25134–25144). Aggregates were categorized into seven discrete classes, based on the traits described. Several additional molecules (from the IgG1 and IgG2 subtypes as well as intravenous IgG) were stressed and found to be defined with the same classification system. The mechanism of protein aggregation and the type of aggregate formed depends on the nature of the stress applied. Different IgG molecules appear to aggregate by a similar mechanism under the same applied stress. Aggregates created by harsh mechanical stress showed the largest number of subvisible particles, and the class generated by thermal stress displayed the largest number of visible particles. Most classes showed a disruption of the higher order structure, with the degree of disorder depending on the stress process. Particles in all classes (except thermal stress) were at least partially reversible upon dilution in pH 5 buffer. High copper content was detected in isolated metal-catalyzed aggregates, a stress previously shown to produce immunogenic aggregates. In conclusion, protein aggregates can be a very heterogeneous population, whose qualities are the result of the type of stress that was experienced. PMID:21454532

  9. Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

    SciTech Connect

    Ouyang, Hui; Ali, Yousuf O.; Ravichandran, Mani; Dong, Aiping; Qiu, Wei; MacKenzie, Farrell; Dhe-Paganon, Sirano; Arrowsmith, Cheryl H.; Zhai, R. Grace

    2012-07-11

    The aggresome pathway is activated when proteasomal clearance of misfolded proteins is hindered. Misfolded polyubiquitinated protein aggregates are recruited and transported to the aggresome via the microtubule network by a protein complex consisting of histone deacetylase 6 (HDAC6) and the dynein motor complex. The current model suggests that HDAC6 recognizes protein aggregates by binding directly to polyubiquitinated proteins. Here, we show that there are substantial amounts of unanchored ubiquitin in protein aggregates with solvent-accessible C termini. The ubiquitin-binding domain (ZnF-UBP) of HDAC6 binds exclusively to the unanchored C-terminal diglycine motif of ubiquitin instead of conjugated polyubiquitin. The unanchored ubiquitin C termini in the aggregates are generated in situ by aggregate-associated deubiquitinase ataxin-3. These results provide structural and mechanistic bases for the role of HDAC6 in aggresome formation and further suggest a novel ubiquitin-mediated signaling pathway, where the exposure of ubiquitin C termini within protein aggregates enables HDAC6 recognition and transport to the aggresome.

  10. Amino acid sequence diversity of the major human papillomavirus capsid protein: Implications for current and next generation vaccines☆

    PubMed Central

    Ahmed, Amina I.; Bissett, Sara L.; Beddows, Simon

    2013-01-01

    Despite the fidelity of host cell polymerases, the human papillomavirus (HPV) displays a degree of genomic polymorphism resulting in distinct genotypes and intra-type variants. The current HPV vaccines target the most prevalent genotypes associated with cervical cancer (HPV16/18) and genital warts (HPV6/11). Although these vaccines confer some measure of cross-protection, a multivalent HPV vaccine is in the pipeline that aims to broaden vaccine protection against other cervical cancer-associated genotypes including HPV31, HPV33, HPV45, HPV52 and HPV58. Both current and next generation vaccines comprise virus-like particles, based upon the major capsid protein, L1, and vaccine-induced, type-specific protection is likely mediated by neutralizing antibodies targeting L1 surface-exposed domains. The aim of this study was to perform an in silico analysis of existing full length L1 sequences representing vaccine-relevant HPV genotypes in order to address the degree of naturally-occurring, intra-type polymorphisms. In total, 1281 sequences from the Americas, Africa, Asia and Europe were assembled. Intra-type entropy was low and/or limited to non-surface-exposed residues for HPV6, HPV11 and HPV52 suggesting a minimal effect on vaccine antibodies for these genotypes. For HPV16, intra-type entropy was high but the present analysis did not reveal any significant polymorphisms not previously identified. For HPV31, HPV33, HPV58, however, intra-type entropy was high, mostly mapped to surface-exposed domains and in some cases within known neutralizing antibody epitopes. For HPV18 and HPV45 there were too few sequences for a definitive analysis, but HPV45 displayed some degree of surface-exposed residue diversity. In most cases, the reference sequence for each genotype represented a minority variant and the consensus L1 sequences for HPV18, HPV31, HPV45 and HPV58 did not reflect the L1 sequence of the currently available HPV pseudoviruses. These data highlight a number of variant

  11. Theory of controlling band-width broadening in terahertz sideband generation in semiconductors by a direct current electric field

    NASA Astrophysics Data System (ADS)

    Liu, Houquan; Zhang, Xingchu

    2017-03-01

    In a semiconductor, optically excited electron-hole pairs, driven by a strong terahertz (THz) field, can recombine to create THz sidebands in the optical spectrum. The sideband spectrum exhibits a "plateau" up to a cutoff frequency of 3.17Up, where Up is the ponderomotive energy. In this letter, we predict that the bandwidth of this sideband spectrum plateau can be broadened by applying an additional direct-current (DC) electric field. We find that if applying a DC field of EDC=0.2ETHz (where EDC and ETHz are the amplitudes of the DC field and THz field, respectively), the sideband spectrum presents three plateaus with 5.8Up, 10.05Up and 16Up being the cutoff frequencies of the first, second and third plateaus, respectively. This bandwidth broadening occurs because the DC field can increase the kinetic energy that an electron-hole pair can gain from the THz field. This effect means that the bandwidth of the sideband spectrum can be controlled flexibly by changing the DC field, thereby facilitating the ultrafast electro-optical applications of THz sideband generation.

  12. Effects of tau domain-specific antibodies and intravenous immunoglobulin on tau aggregation and aggregate degradation.

    PubMed

    Esteves-Villanueva, Jose O; Trzeciakiewicz, Hanna; Loeffler, David A; Martić, Sanela

    2015-01-20

    Tau pathology, including neurofibrillary tangles, develops in Alzheimer's disease (AD). The aggregation and hyperphosphorylation of tau are potential therapeutic targets for AD. Administration of anti-tau antibodies reduces tau pathology in transgenic "tauopathy" mice; however, the optimal tau epitopes and conformations to target are unclear. Also unknown is whether intravenous immunoglobulin (IVIG) products, currently being evaluated in AD trials, exert effects on pathological tau. This study examined the effects of anti-tau antibodies targeting different tau epitopes and the IVIG Gammagard on tau aggregation and preformed tau aggregates. Tau aggregation was assessed by transmission electron microscopy and fluorescence spectroscopy, and the binding affinity of the anti-tau antibodies for tau was evaluated by enzyme-linked immunosorbent assays. Antibodies used were anti-tau 1-150 ("D-8"), anti-tau 259-266 ("Paired-262"), anti-tau 341-360 ("A-10"), and anti-tau 404-441 ("Tau-46"), which bind to tau's N-terminus, microtubule binding domain (MBD) repeat sequences R1 and R4, and the C-terminus, respectively. The antibodies Paired-262 and A-10, but not D-8 and Tau-46, reduced tau fibrillization and degraded preformed tau aggregates, whereas the IVIG reduced tau aggregation but did not alter preformed aggregates. The binding affinities of the antibodies for the epitope for which they were specific did not appear to be related to their effects on tau aggregation. These results confirm that antibody binding to tau's MBD repeat sequences may inhibit tau aggregation and indicate that such antibodies may also degrade preformed tau aggregates. In the presence of anti-tau antibodies, the resulting tau morphologies were antigen-dependent. The results also suggested the possibility of different pathways regulating antibody-mediated inhibition of tau aggregation and antibody-mediated degradation of preformed tau aggregates.

  13. Aggregate and the environment

    USGS Publications Warehouse

    Langer, William H.; Drew, Lawrence J.; Sachs, J.S.

    2004-01-01

    This book is designed to help you understand our aggregate resources-their importance, where they come from, how they are processed for our use, the environmental concerns related to their mining and processing, how those concerns are addressed, and the policies and regulations designed to safeguard workers, neighbors, and the environment from the negative impacts of aggregate mining. We hope this understanding will help prepare you to be involved in decisions that need to be made-individually and as a society-to be good stewards of our aggregate resources and our living planet.

  14. Active matter model of Myxococcus xanthus aggregation

    NASA Astrophysics Data System (ADS)

    Patch, Adam; Bahar, Fatmagul; Liu, Guannan; Thutupalli, Shashi; Welch, Roy; Yllanes, David; Shaevitz, Joshua; Marchetti, M. Cristina

    Myxococcus xanthus is a soil-dwelling bacterium that exhibits several fascinating collective behaviors including streaming, swarming, and generation of fruiting bodies. A striking feature of M. xanthus is that it periodically reverses its motility direction. The first stage of fruiting body formation is characterized by the aggregation of cells on a surface into round mesoscopic structures. Experiments have shown that this aggregation relies heavily on regulation of the reversal rate and local mechanical interactions, suggesting motility-induced phase separation may play an important role. We have adapted self-propelled particle models to include cell reversal and motility suppression resulting from sporulation observed in aggregates. Using 2D molecular dynamics simulations, we map the phase behavior in the space of Péclet number and local density and examine the kinetics of aggregation for comparison to experiments.

  15. Protein aggregation in a membrane environment.

    PubMed

    Gorbenko, Galyna; Trusova, Valeriya

    2011-01-01

    Biological membranes are featured by a remarkable ability to modulate a wide range of physiological and pathological processes. Of these, protein aggregation is currently receiving the greatest attention, as one type of the ordered protein aggregates, amyloid fibrils, proved to be involved in molecular etiology of a number of fatal diseases. It has been hypothesized that nucleation of amyloid fibrils and toxic action of their precursors is mediated by lipid-protein interactions. Lipid bilayer provides a variety of environments in which aggregated state of polypeptide chain appears to be more thermodynamically favorable than its monomeric form. The major factors responsible for the enhanced self-association propensity of membrane-bound proteins include (i) structural transition of polypeptide chain into aggregation-prone conformation; (ii) protein crowding in a lipid phase; (iii) particular aggregation-favoring orientation and bilayer embedment of the protein molecules. All these factors are considered in the present review with an emphasis being put on the role of electrostatic, hydrophobic, and hydrogen-bonding phenomena in initiating and modulating the protein aggregation on a membrane template. Likewise, we survey the advanced experimental techniques employed for detection and structural characterization of the aggregated species in membrane systems.

  16. Marine aggregate dynamics

    NASA Astrophysics Data System (ADS)

    The direction and scope of the Office of Naval Research's Marine Aggregate Dynamics Accelerated Research Initiative will be the topic of an open-house style meeting February 14, 7:30-10:00 P.M. in Ballroom D of the Hyatt Regency New Orleans at the Louisiana Superdome. This meeting is scheduled during the AGU/American Society of Limnology and Oceanography Ocean Sciences Meeting February 12-16 in New Orleans.The critical focus of the ARI is the measurement and modeling of the dynamics of the biological, physical, chemical and molecular processes that drive aggregation and produce aggregates. This new ARI will provide funding in Fiscal Years 1991-1995 to identify and quantify mechanisms that determine the distribution, abundance and size spectrum of aggregated particulate matter in the ocean.

  17. Protein Colloidal Aggregation Project

    NASA Technical Reports Server (NTRS)

    Oliva-Buisson, Yvette J. (Compiler)

    2014-01-01

    To investigate the pathways and kinetics of protein aggregation to allow accurate predictive modeling of the process and evaluation of potential inhibitors to prevalent diseases including cataract formation, chronic traumatic encephalopathy, Alzheimer's Disease, Parkinson's Disease and others.

  18. Aggregation and Averaging.

    ERIC Educational Resources Information Center

    Siegel, Irving H.

    The arithmetic processes of aggregation and averaging are basic to quantitative investigations of employment, unemployment, and related concepts. In explaining these concepts, this report stresses need for accuracy and consistency in measurements, and describes tools for analyzing alternative measures. (BH)

  19. Saturation Ion Current Densities in Inductively Coupled Hydrogen Plasma Produced by Large-Power Radio Frequency Generator

    NASA Astrophysics Data System (ADS)

    Wang, Songbai; Lei, Guangjiu; Bi, Zhenhua; Ghomi, H.; Yang, Size; Liu, Dongping

    2016-09-01

    An experimental investigation of the saturation ion current densities (Jions) in hydrogen inductively coupled plasma (ICP) produced by a large-power (2-32 kW) radio frequency (RF) generator is reported, then some reasonable explanations are given out. With the increase of RF power, the experimental results show three stages: in the first stage (2-14 kW), the electron temperature will rise with the increase of RF power in the ICP, thus, the Jions increases continually as the electron temperature rises in the ICP. In the second stage (14-20 kW), as some H- ions lead to the mutual neutralization (MN), the slope of Jions variation firstly decreases then increases. In the third stage (20-32 kW), both the electronic detachment (ED) and the associative detachment (AD) in the ICP result in the destruction of H- ions, therefore, the increased amplitude of the Jions in the third stage is weaker than the one in the first stage. In addition, with the equivalent transformer model, we successfully explain that the Jions at different radial locations in ICP has the same rule. Finally, it is found that the Jions has nothing to do with the outer/inner puffing gas pressure ratio, which is attributed to the high-speed movement of hydrogen molecules. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2011GB108011 and 2010GB103001), the Major International (Regional) Project Cooperation and Exchanges of China (No. 11320101005) and the Startup Fund from Fuzhou University (No. 510071)

  20. Three-dimensional MHD simulation of the interaction of the solar wind with the earth's magnetosphere: The generation of field-aligned currents

    SciTech Connect

    Ogino, T.

    1986-06-01

    A global computer simulation of the interaction of the solar wind with the earth's magnetosphere was executed by using a three-dimensional magnetohydrodynamic model. As a result, we were able to reproduce quasi-steady-state magnetospheric configurations and a Birkeland field-aligned current system which depend on the polarity of the z-italic component of the interplanetary magnetic field (IMF). Twin convection cells and a dawn to dusk electric potential of 30--100 kV appeared at the equator in the magnetosphere. Four types of field-aligned currents were observed. Region 1 and 2 field-aligned currents generated for all IMF conditions were 0.6--1.0 x 10/sup 6/ A and 0.15--0.61 x 10/sup 6/ A, respectively, in the total current. Region 1 currents at high latitudes are generated from the field-aligned vorticity at the flanks through a viscous interaction and are strengthened by a twisting of open magnetic field lines in the tail region for southward IMF. On the other hand, the low-latitude region 2 currents probably are generated mainly from the inner pressure gradient of the plasma sheet. The region 1 current obtained from the simulation was in good agreement with an estimate from our theoretical analysis of the localized Alfve-acute-accentn mode. The other two types of field-aligned currents are the dayside magnetopause currents in the dayside cusp region, which increase for northward IMF, and the dayside cusp currents for southward IMF. The cusp currents are associated with a twisting of open magnetic field lines in the magnetopause region.

  1. Lateral current generation in n-AlGaAs/GaAs heterojunction channels by Schottky-barrier gate illumination

    SciTech Connect

    Kawazu, Takuya; Noda, Takeshi; Sakuma, Yoshiki; Sakaki, Hiroyuki

    2015-01-12

    We observe lateral currents induced in an n-AlGaAs/GaAs heterojunction channel of Hall bar geometry, when an asymmetric position of the Schottky metal gate is locally irradiated by a near-infrared laser beam. When the left side of the Schottky gate is illuminated with the laser, the lateral current flows from left to right in the two dimensional electron gas (2DEG) channel. In contrast, the right side illumination leads to the current from right to left. The magnitude of the lateral current is almost linearly dependent on the beam position, the current reaching its maximum for the beam at the edge of the Schottky gate. The experimental findings are well explained by a theory based on the current-continuity equation, where the lateral current in the 2DEG channel is driven by the photocurrent which vertically flows from the 2DEG to the Schottky gate.

  2. Eddy Effects in the General Circulation, Spanning Mean Currents, Mesoscale Eddies, and Topographic Generation, Including Submesoscale Nests

    DTIC Science & Technology

    2013-09-30

    Eddies, and Topographic Generation, Including Submesoscale Nests Alexander F. Shchepetkin (PI) James C. McWilliams and Maarten J. Molemaker (co-PIs... submesoscale phenomena; analysis and understanding the underlying physical processes; improving parameterizations of unresolved processes...mesoscale and submesoscale eddies generated by instability and bottom topography effects. This is accompanied by development of modeling codes

  3. Modeling and visualization of carrier motion in organic films by optical second harmonic generation and Maxwell-displacement current

    NASA Astrophysics Data System (ADS)

    Iwamoto, Mitsumasa; Manaka, Takaaki; Taguchi, Dai

    2015-09-01

    The probing and modeling of carrier motions in materials as well as in electronic devices is a fundamental research subject in science and electronics. According to the Maxwell electromagnetic field theory, carriers are a source of electric field. Therefore, by probing the dielectric polarization caused by the electric field arising from moving carriers and dipoles, we can find a way to visualize the carrier motions in materials and in devices. The techniques used here are an electrical Maxwell-displacement current (MDC) measurement and a novel optical method based on the electric field induced optical second harmonic generation (EFISHG) measurement. The MDC measurement probes changes of induced charge on electrodes, while the EFISHG probes nonlinear polarization induced in organic active layers due to the coupling of electron clouds of molecules and electro-magnetic waves of an incident laser beam in the presence of a DC field caused by electrons and holes. Both measurements allow us to probe dynamical carrier motions in solids through the detection of dielectric polarization phenomena originated from dipolar motions and electron transport. In this topical review, on the basis of Maxwell’s electro-magnetism theory of 1873, which stems from Faraday’s idea, the concept for probing electron and hole transport in solids by using the EFISHG is discussed in comparison with the conventional time of flight (TOF) measurement. We then visualize carrier transit in organic devices, i.e. organic field effect transistors, organic light emitting diodes, organic solar cells, and others. We also show that visualizing an EFISHG microscopic image is a novel way for characterizing anisotropic carrier transport in organic thin films. We also discuss the concept of the detection of rotational dipolar motions in monolayers by means of the MDC measurement, which is capable of probing the change of dielectric spontaneous polarization formed by dipoles in organic monolayers. Finally we

  4. Simultaneous visualization of oxygen partial pressure, current density, and water droplets in serpentine fuel cell during power generation for understanding reaction distributions

    NASA Astrophysics Data System (ADS)

    Takanohashi, Kazuhiro; Suga, Takeo; Uchida, Makoto; Ueda, Toshihide; Nagumo, Yuzo; Inukai, Junji; Nishide, Hiroyuki; Watanabe, Masahiro

    2017-03-01

    Understanding the reaction distributions inside a polymer electrolyte fuel cell (PEFC) is essential for the higher performance and durability. We have developed a new see-through cell and visualized the distributions of oxygen partial pressure and current density inside a running PEFC at the temperature of 40 and 80 °C and the relative humidity of 53%. The oxygen utilization was changed from 0% to 80% by changing the current density. At higher oxygen utilizations, the current density was higher and therefore the water generation. Generated water droplets in the flow channel were also visualized, allowing for the simultaneous visualization of the distribution of the oxygen partial pressure, current density, and water droplets. By combining the observations of all three parameters, the reactions inside a membrane-electrode assembly were discussed.

  5. Analyses of Current-Generating Mechanisms of Shewanella loihica PV-4 and Shewanella oneidensis MR-1 in Microbial Fuel Cells ▿ †

    PubMed Central

    Newton, Gregory J.; Mori, Shigeki; Nakamura, Ryuhei; Hashimoto, Kazuhito; Watanabe, Kazuya

    2009-01-01

    Although members of the genus Shewanella have common features (e.g., the presence of decaheme c-type cytochromes [c-cyts]), they are widely variable in genetic and physiological features. The present study compared the current-generating ability of S. loihica PV-4 in microbial fuel cells (MFCs) with that of well-characterized S. oneidensis MR-1 and examined the roles of c-cyts in extracellular electron transfer. We found that strains PV-4 and MR-1 exhibited notable differences in current-generating mechanisms. While the MR-1 MFCs maintained a constant current density over time, the PV-4 MFCs continued to increase in current density and finally surpassed the MR-1 MFCs. Coulombic efficiencies reached 26% in the PV-4 MFC but 16% in the MR-1 MFCs. Although both organisms produced quinone-like compounds, anode exchange experiments showed that anode-attached cells of PV-4 produced sevenfold more current than planktonic cells in the same chamber, while planktonic cells of MR-1 produced twice the current of the anode-attached cells. Examination of the genome sequence indicated that PV-4 has more c-cyt genes in the metal reductase-containing locus than MR-1. Mutational analysis revealed that PV-4 relied predominantly on a homologue of the decaheme c-cyt MtrC in MR-1 for current generation, even though it also possesses two homologues of the decaheme c-cyt OmcA in MR-1. These results suggest that current generation in a PV-4 MFC is in large part accomplished by anode-attached cells, in which the MtrC homologue constitutes the main path of electrons toward the anode. PMID:19837834

  6. Photonic generation of ultra-wideband signals by direct current modulation on SOA section of an SOA-integrated SGDBR laser.

    PubMed

    Lv, Hui; Yu, Yonglin; Shu, Tan; Huang, Dexiu; Jiang, Shan; Barry, Liam P

    2010-03-29

    Photonic ultra-wideband (UWB) pulses are generated by direct current modulation of a semiconductor optical amplifier (SOA) section of an SOA-integrated sampled grating distributed Bragg reflector (SGDBR) laser. Modulation responses of the SOA section of the laser are first simulated with a microwave equivalent circuit model. Simulated results show a resonance behavior indicating the possibility to generate UWB signals with complex shapes in the time domain. The UWB pulse generation is then experimentally demonstrated for different selected wavelength channels with an SOA-integrated SGDBR laser.

  7. Concrete Waste Recycling Process for High Quality Aggregate

    SciTech Connect

    Ishikura, Takeshi; Fujii, Shin-ichi

    2008-01-15

    Large amount of concrete waste generates during nuclear power plant (NPP) dismantling. Non-contaminated concrete waste is assumed to be disposed in a landfill site, but that will not be the solution especially in the future, because of decreasing tendency of the site availability and natural resources. Concerning concrete recycling, demand for roadbeds and backfill tends to be less than the amount of dismantled concrete generated in a single rural site, and conventional recycled aggregate is limited of its use to non-structural concrete, because of its inferior quality to ordinary natural aggregate. Therefore, it is vital to develop high quality recycled aggregate for general uses of dismantled concrete. If recycled aggregate is available for high structural concrete, the dismantling concrete is recyclable as aggregate for industry including nuclear field. Authors developed techniques on high quality aggregate reclamation for large amount of concrete generated during NPP decommissioning. Concrete of NPP buildings has good features for recycling aggregate; large quantity of high quality aggregate from same origin, record keeping of the aggregate origin, and little impurities in dismantled concrete such as wood and plastics. The target of recycled aggregate in this development is to meet the quality criteria for NPP concrete as prescribed in JASS 5N 'Specification for Nuclear Power Facility Reinforced Concrete' and JASS 5 'Specification for Reinforced Concrete Work'. The target of recycled aggregate concrete is to be comparable performance with ordinary aggregate concrete. The high quality recycled aggregate production techniques are assumed to apply for recycling for large amount of non-contaminated concrete. These techniques can also be applied for slightly contaminated concrete dismantled from radiological control area (RCA), together with free release survey. In conclusion: a technology on dismantled concrete recycling for high quality aggregate was developed

  8. Multi-scale interactions in Dictyostelium discoideum aggregation

    NASA Astrophysics Data System (ADS)

    Dixon, James A.; Kelty-Stephen, Damian G.

    2012-12-01

    Cellular aggregation is essential for a wide range of phenomena in developmental biology, and a crucial event in the life-cycle of Dictyostelium discoideum. The current manuscript presents an analysis of multi-scale interactions involved in D. discoideum aggregation and non-aggregation events. The multi-scale fractal dimensions of a sequence of microscope images were used to estimate changing structure at different spatial scales. Three regions showing aggregation and three showing non-aggregation were considered. The results showed that both aggregation and non-aggregation regions were strongly multi-fractal. Analyses of the over-time relationships among nine scales of the generalized dimension, D(q), were conducted using vector autoregression and vector error-correction models. Both types of regions showed evidence that across-scale interactions serve to maintain the equilibrium of the system. Aggregation and non-aggregation regions also showed different patterns of effects of individual scales on other scales. Specifically, aggregation regions showed greater effects of both the smallest and largest scales on the smaller scale structures. The results suggest that multi-scale interactions are responsible for maintaining and altering the cellular structures during aggregation.

  9. Thermonuclear ignition by Z-pinch X-ray radiation produced by current of an explosive magnetic generator

    NASA Astrophysics Data System (ADS)

    Garanin, S. G.; Ivanovskiy, A. V.

    2015-12-01

    The scheme of a device based a superpower disk-type magnetic explosion generator to produce a pulse of X-ray radiation with the energy exceeding the target ignition threshold is described and validated.

  10. Thermonuclear ignition by Z-pinch X-ray radiation produced by current of an explosive magnetic generator

    SciTech Connect

    Garanin, S. G.; Ivanovskiy, A. V.

    2015-12-15

    The scheme of a device based a superpower disk-type magnetic explosion generator to produce a pulse of X-ray radiation with the energy exceeding the target ignition threshold is described and validated.

  11. High gain GaAs Photoconductive Semiconductor Switches (PCSS): Device lifetime, high current testing, optical pulse generators

    SciTech Connect

    Zutavern, F.J.; Loubriel, G.M.; Helgeson, W.D.; O`Malley, M.W.; Gallegos, R.R.; Hjalmarson, H.P.; Baca, A.G.; Plut, T.A.

    1995-12-31

    This paper presents results from three areas of GaAs PCSS research and development: device lifetime, high current switching, and PCSS-driven laser diode arrays (LDA). The authors have performed device lifetime tests on both lateral and vertical switches as a function of current amplitude, pulse width, and charging time. At present, their longest-lived switch reached 4 {times} 10{sup 6} pulses. Scanning electron microscope (SEM) images show damage near the contacts even after only 5 pulses. They are presently searching for the threshold at which no damage is evident after a single shot. In high current tests, they have reached 5.2 kA at 4.2 kV. This was achieved using twenty fiber-optic coupled lasers to distribute current filaments over a 5 mm wide PCSS. Current waveforms and images of the current filaments as a function of current amplitude will be presented. The lasers used to trigger the high current PCSS were driven with a miniature PCSS. Low inductance, high speed GaAs PCSS are very effective as short pulse laser diode array drivers. Some types of arrays gain switch, producing a compressed optical pulse which is only 75 ps wide. Results from tests with a variety of laser diode arrays will be presented.

  12. Technology meets aggregate

    SciTech Connect

    Wilson, C.; Swan, C.

    2007-07-01

    New technology carried out at Tufts University and the University of Massachusetts on synthetic lightweight aggregate has created material from various qualities of fly ash from coal-fired power plants for use in different engineered applications. In pilot scale manufacturing tests an 'SLA' containing 80% fly ash and 20% mixed plastic waste from packaging was produced by 'dry blending' mixed plastic with high carbon fly ash. A trial run was completed to produce concrete masonry unit (CMU) blocks at a full-scale facility. It has been shown that SLA can be used as a partial substitution of a traditional stone aggregate in hot asphalt mix. 1 fig., 2 photos.

  13. Ground-Based Experiment of Current Collection to Bare Tether in High-Speed and High-Density Plasma Generated by Hall Thrusters

    SciTech Connect

    Kohori, Tatsuya; Ikeda, Tomoyuki; Shimizu, Masaharu; Takagi, Hiroki; Yamada, Minetsugu; Tahara, Hirokazu

    2008-12-31

    Bare-tether systems are one of the greatest-efficiency electrodynamic tethered systems. The system with an uninsulated portion of the metallic tether itself to collect electrons from the space plasma is operated as a thruster or a power generator on a satellite. Ground-based experiments were carried out to understand phenomena of electron collection by a bare tether in space. Metallic tether samples were exposed to a simulating Low-Earth-Orbit plasma flow as varying tether sample diameter and length, and plasma velocity. A magnetic field was also applied. The normalized collection current increased with normalized tether sample potential. The tether sample diameter did not influence the normalized collection current characteristics although an increase in tether sample length decreased the normalized collection current in this experiment. The collection current characteristics were independent of plasma velocity under meso-thermal conditions. The existence of magnetic field raised the collection current because of the three-dimensional current collection effect at the edge of a tether sample under the magnetic field. Although the existence of magnetic field may raise the collection current, the effect will be small with a long tether. Accordingly, the dependence of tether diameter and length, plasma velocity and magnetic field on collection current characteristics of a bare tether in space might be small. The collection current may not exceed the OML current.

  14. Dual Optimization Method of RF and Quasi-Static Field Simulations for Reduction of Eddy Currents Generated on 7T RF Coil Shielding

    PubMed Central

    Zhao, Yujuan; Zhao, Tiejun; Raval, Shailesh B.; Krishnamurthy, Narayanan; Zheng, Hai; Harris, Chad T.; Handler, William B.; Chronik, Blaine A.; Ibrahim, Tamer S.

    2015-01-01

    Purpose To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms. Methods One set of a four-element, 2×2 Tic-Tac-Toe (TTT) head coil structure is selected and constructed to study eddy currents on the RF coil shielding. The generated eddy currents are quantitatively studied in the time and frequency domains. The RF characteristics are studied using the finite-difference time-domain (FDTD) method. Five different kinds of RF shielding were tested on a 7T MRI scanner with phantoms and in-vivo human subjects. Results The eddy current simulation method is verified by the measurement results. Eddy currents induced by solid/intact and simple-structured slotted RF shielding can significantly distort the gradient fields. EPI images, B1+ maps and S matrix measurements verified that the proposed slot pattern can suppress the eddy currents while maintaining the RF characteristics of the transmit coil. Conclusion The presented dual-optimization method could be used to design the RF shielding and reduce the gradient field-induced eddy currents while maintaining the RF characteristics of the transmit coil. PMID:25367703

  15. Generation of low-frequency nonlinear currents in plasma by an ultrashort pulse of high-frequency radiation

    SciTech Connect

    Grishkov, V. E.; Uryupin, S. A.

    2015-07-15

    A kinetic theory of low-frequency currents induced in plasma by an ultrashort high-frequency radiation pulse is developed. General expressions for the currents flowing along the propagation direction of the pulse and along the gradient of the field energy density are analyzed both analytically and numerically for pulse durations longer or shorter than or comparable with the electron collision time in plasma. It is demonstrated that the nonlinear current flowing along the gradient of the field energy density can be described correctly only when the modification of the isotropic part of the electron distribution function is taken into account.

  16. A Study on the Observation of Direct Lightning Current through the Wind Turbine Generator System in the Coast of the Japan Sea

    NASA Astrophysics Data System (ADS)

    Shiraishi, Yasuhiro; Otsuka, Takahiro; Matsuura, Hideki

    As clean energy that solves energy resources, many wind turbine generator systems have developed up to now, in Japan. The generation capacity of wind power is above 1 million kW, and the construction also continues from now on. The wind turbine generator systems are built in the good place of the wind condition, and those many are built on the coast of the Japan Sea. However, the coast of the Japan Sea is known as a place with much winter lightning, and wind turbine generator systems also often suffer the damage by winter lightning. The authors observed the lightning current that strikes through the wind turbine generator systems directly, in order to establish on the lightning protection of them. The authors acquired dozens of data as a result of observation in Akita Japan for 17 months. Based on these data, some considerations were performed about the performance of winter lightning that struck through the wind turbine generator systems. As the result of consideration, we found some interesting knowledge following sentence. It made clear anew that the tower which is a place of high position from the ground and on the windward has much number of lightning flash and many total flash charges. The lightning stroke current divided the tower pipe and ground leads. About 70% of the observed lightning current flowed to the tower pipe, and about 30% is divided into two grounding leads connected to the leg of tower. All of steep current that is on a wave front flow a tower side, it dose not flow to a grounding leads side. The distributions of lightning parameters between our observation results and past one are in good conformity.

  17. Design of a high-current low-energy beam transport line for an intense D-T/D-D neutron generator

    NASA Astrophysics Data System (ADS)

    Lu, Xiaolong; Wang, Junrun; Zhang, Yu; Li, Jianyi; Xia, Li; Zhang, Jie; Ding, Yanyan; Jiang, Bing; Huang, Zhiwu; Ma, Zhanwen; Wei, Zheng; Qian, Xiangping; Xu, Dapeng; Lan, Changlin; Yao, Zeen

    2016-03-01

    An intense D-T/D-D neutron generator is currently being developed at the Lanzhou University. The Cockcroft-Walton accelerator, as a part of the neutron generator, will be used to accelerate and transport the high-current low-energy beam from the duoplasmatron ion source to the rotating target. The design of a high-current low-energy beam transport (LEBT) line and the dynamics simulations of the mixed beam were carried out using the TRACK code. The results illustrate that the designed beam line facilitates smooth transportation of a deuteron beam of 40 mA, and the number of undesired ions can be reduced effectively using two apertures.

  18. A new high-precision furnace for paleomagnetic and paleointensity studies: Minimizing magnetic noise generated by heater currents inside traditional thermal demagnetizers

    NASA Astrophysics Data System (ADS)

    Zheng, Zhong; Zhao, Xixi; Horng, Chorng-Shern

    2010-04-01

    Although magnetic noise fields generated by heater currents in thermal demagnetizers have been noticed for a long time, no satisfactory tests have been conducted to quantify their effects. Toward this end, we have developed a new high-precision thermal demagnetizer that greatly reduces the magnetic noise field. We show the data quality generated by the new oven and the comparative results on several real samples that demonstrate the effects of the magnetic noise field due to heater currents. The properties of the spurious magnetization emanating from the heater currents critically depend on the decay rate of amplitude and its waveform of electric power which is delivered to oven coils at the end of the heating stage of thermal demagnetization. These results also illustrate the potential applications of this new instrument in paleomagnetism and paleointensity studies.

  19. A comparison of thermal zone aggregation methods

    SciTech Connect

    Dobbs, Justin R.; Hencey, Brandon M.

    2012-12-10

    The impact of increasing energy prices on building operation budgets has fueled demand for more energy-efficient structures. Existing building energy simulation tools generate an immense amount of data yet comparatively little knowledge. This paper introduces a framework that allows aggregation-based model reduction to operate on geometric building information models. The resulting aggregation sequence provides designers with faster simulations and affords insight into complex multi-scale thermal interactions. A comparison of the trade-off between simulation speed and accuracy for three hierarchical cluster partitioning methods concludes the discussion.

  20. Aggregates, broccoli and cauliflower

    NASA Astrophysics Data System (ADS)

    Grey, Francois; Kjems, Jørgen K.

    1989-09-01

    Naturally grown structures with fractal characters like broccoli and cauliflower are discussed and compared with DLA-type aggregates. It is suggested that the branching density can be used to characterize the growth process and an experimental method to determine this parameter is proposed.

  1. High-accuracy current generation in the nanoampere regime from a silicon single-trap electron pump

    PubMed Central

    Yamahata, Gento; Giblin, Stephen P.; Kataoka, Masaya; Karasawa, Takeshi; Fujiwara, Akira

    2017-01-01

    A gigahertz single-electron (SE) pump with a semiconductor charge island is promising for a future quantum current standard. However, high-accuracy current in the nanoampere regime is still difficult to achieve because the performance of SE pumps tends to degrade significantly at frequencies exceeding 1 GHz. Here, we demonstrate robust SE pumping via a single-trap level in silicon up to 7.4 GHz, at which the pumping current exceeds 1 nA. An accuracy test with an uncertainty of about one part per million (ppm) reveals that the pumping current deviates from the ideal value by only about 20 ppm at the flattest part of the current plateau. This value is two orders of magnitude better than the best one reported in the nanoampere regime. In addition, the pumping accuracy is almost unchanged up to 7.4 GHz, probably due to strong electron confinement in the trap. These results indicate that trap-mediated SE pumping is promising for achieving the practical operation of the quantum current standard. PMID:28322339

  2. High-accuracy current generation in the nanoampere regime from a silicon single-trap electron pump

    NASA Astrophysics Data System (ADS)

    Yamahata, Gento; Giblin, Stephen P.; Kataoka, Masaya; Karasawa, Takeshi; Fujiwara, Akira

    2017-03-01

    A gigahertz single-electron (SE) pump with a semiconductor charge island is promising for a future quantum current standard. However, high-accuracy current in the nanoampere regime is still difficult to achieve because the performance of SE pumps tends to degrade significantly at frequencies exceeding 1 GHz. Here, we demonstrate robust SE pumping via a single-trap level in silicon up to 7.4 GHz, at which the pumping current exceeds 1 nA. An accuracy test with an uncertainty of about one part per million (ppm) reveals that the pumping current deviates from the ideal value by only about 20 ppm at the flattest part of the current plateau. This value is two orders of magnitude better than the best one reported in the nanoampere regime. In addition, the pumping accuracy is almost unchanged up to 7.4 GHz, probably due to strong electron confinement in the trap. These results indicate that trap-mediated SE pumping is promising for achieving the practical operation of the quantum current standard.

  3. Aggregation Trade Offs in Family Based Recommendations

    NASA Astrophysics Data System (ADS)

    Berkovsky, Shlomo; Freyne, Jill; Coombe, Mac

    Personalized information access tools are frequently based on collaborative filtering recommendation algorithms. Collaborative filtering recommender systems typically suffer from a data sparsity problem, where systems do not have sufficient user data to generate accurate and reliable predictions. Prior research suggested using group-based user data in the collaborative filtering recommendation process to generate group-based predictions and partially resolve the sparsity problem. Although group recommendations are less accurate than personalized recommendations, they are more accurate than general non-personalized recommendations, which are the natural fall back when personalized recommendations cannot be generated. In this work we present initial results of a study that exploits the browsing logs of real families of users gathered in an eHealth portal. The browsing logs allowed us to experimentally compare the accuracy of two group-based recommendation strategies: aggregated group models and aggregated predictions. Our results showed that aggregating individual models into group models resulted in more accurate predictions than aggregating individual predictions into group predictions.

  4. Volcanic ash aggregation in the lab - can we mimic natural processes?

    NASA Astrophysics Data System (ADS)

    Mueller, Sebastian B.; Kueppers, Ulrich; Jacob, Michael; Ayris, Paul; Cimarelli, Corrado; Dingwell, Donald B.; Guttzeit, Melanie; Hess, Kai-Uwe; Walter, Ulrich

    2015-04-01

    Explosive volcanic eruptions release large amounts of particles into the atmosphere. Volcanic ash, by definition pyroclasts smaller than 2 mm, can be distributed around the globe by prevailing winds. Ash poses hazards to aviation industry by melting in jet turbines, to human health by entering respiration systems and to society by damaging infrastructure. Under certain circumstances, ash particles can cluster together and build ash aggregates. Aggregates range in size from few mm to few cm and may exhibit complex internal stratigraphy. During growth, weight, density and aerodynamic properties change, leading to a significantly different settling behavior compared to individual ash particles. Although ash aggregation has been frequently observed in the geologic record, the physical and chemical mechanisms generating the aggregates remain poorly understood. During several field campaigns, we collected numerous ash aggregates and analyzed their textural, chemical and mechanical properties. Based on this knowledge, we have designed experiments using the ProCell Lab System® of Glatt Ingenieurtechnik GmbH, Germany. In this device, a continuous fluidized bed can be applied on solid particles and simulate gas-particle flow conditions as they would be expected in volcanic plumes or pyroclastic density currents. The geological record and direct observations have shown that both processes are capable of producing ash aggregates. As starting material we used Na-glass beads as an analogue and volcanic ash from Laacher See Volcano, Eifel Volcanic Field, Germany. We define parameters such as grainsize, specific surface area and concentration of the starting material, degree of turbulence, temperature and moisture in the process chamber and the composition of the liquid phase to influence form, size, stability and production rate of aggregates. We were able to experimentally produce round, unstructured ash pellets up to 5mm in diameter. A detailed textural description highlights

  5. Sectoral shifts and aggregate unemployment

    SciTech Connect

    Loungani, P.

    1986-01-01

    Some recent research has taken the view that sectoral or industry-specific shocks significantly affect aggregate unemployment by increasing the amount of inter-industry labor reallocation required. The empirical evidence for this view rests on the finding that during the 1950s - and again during the 1970s - there was a positive correlation between aggregate unemployment and the dispersion of employment growth rates. This thesis demonstrates that this correlation arises largely because oil price shocks affect both unemployment and the dispersion of employment growth. Once the dispersion due to oil shocks is accounted for, the residual dispersion in employment has very low explanatory power for unemployment. Since the dispersion index does not measure pure sectoral shifts, an alternate measure of dispersion is developed that serves as a better proxy for the amount of inter-industry labor reallocation required each period. Estimates using this measure suggest that, during the 1950s, temporary increases in the relative price of oil were responsible for generating the observed correlation. On the other hand, sectoral shifts were important during the 1970s; in particular, the 1973 oil price increase has had significant reallocative effects on the economy. This contention is subjected to further tests by looking at the time-series behavior of employment in durable-goods industries and also by following the inter-industry movements of workers over time through the use of panel data.

  6. Current advances in the generation of human iPS cells: implications in cell-based regenerative medicine.

    PubMed

    Revilla, Ana; González, Clara; Iriondo, Amaia; Fernández, Bárbara; Prieto, Cristina; Marín, Carlos; Liste, Isabel

    2016-11-01

    Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, several limitations still affect the possibility of applying iPS cell-based technology in therapeutic prospects. Most strategies for iPSCs generation are based on gene delivery via retroviral or lentiviral vectors, which integrate into the host's cell genome, causing a remarkable risk of insertional mutagenesis and oncogenic transformation. To avoid such risks, significant advances have been made with non-integrative reprogramming strategies. On the other hand, although many different kinds of somatic cells have been employed to generate iPSCs, there is still no consensus about the ideal type of cell to be reprogrammed. In this review we present the recent advances in the generation of human iPSCs, discussing their advantages and limitations in terms of safety and efficiency. We also present a selection of somatic cell sources, considering their capability to be reprogrammed and tissue accessibility. From a translational medicine perspective, these two topics will provide evidence to elucidate the most suitable combination of reprogramming strategy and cell source to be applied in each human iPSC-based therapy. The wide variety of diseases this technology could treat opens a hopeful future for regenerative medicine. Copyright © 2015 John Wiley & Sons, Ltd.

  7. New-generation empirical magnetic field models: Increasing resolution of equatorial and Birkeland currents and transition from modeling to nowcasting

    NASA Astrophysics Data System (ADS)

    Stephens, G. K.; Sitnov, M. I.; Redmon, R. J.

    2015-12-01

    Classical empirical geomagnetic field models were built using rigid electric current modules whose amplitude and size were determined by predefined functions of solar wind and global parameters, which limited their ability to reconstruct the global morphology of the magnetosphere and its dynamic evolution during geomagnetic storms. The TS07D model mitigated these limitations by replacing the equatorial current modules with basis-function expansions and by introducing a dynamical binning approach based on nearest neighbors. Here we further progress this avenue. Firstly, the number of basis functions is increased and new data from Van Allen Probes and THEMIS missions is added, allowing the model to resolve the spatial structure and evolution of the innermost eastward and banana currents. Then, an enhanced Birkeland current module that more accurately reconstructs the realistic morphology, including the Harang discontinuity and IMF By dependence, is discussed. Lastly, the performance of various nowcasting versions of the model with different sets of the binning parameters is examined for the first time using their direct validation by in-situ geomagnetic field observations, leading to an optimum nowcasting version of the model. Furthermore, the plasma pressure is reconstructed assuming force balance with the empirical magnetic field, and the role of pressure-driven currents is examined.

  8. Organic carbon, water repellency and soil stability to slaking at aggregate and intra-aggregate scales

    NASA Astrophysics Data System (ADS)

    Jordán López, Antonio; García-Moreno, Jorge; Gordillo-Rivero, Ángel J.; Zavala, Lorena M.; Cerdà, Artemi; Alanís, Nancy; Jiménez-Compán, Elizabeth

    2015-04-01

    Water repellency (WR) is a property of some soils that inhibits or delays water infiltration between a few seconds and days or weeks. Inhibited or delayed infiltration contributes to ponding and increases runoff flow generation, often increasing soil erosion risk. In water-repellent soils, water infiltrates preferentially through cracks or macropores, causing irregular soil wetting patterns, the development of preferential flow paths and accelerated leaching of nutrients. Although low inputs of hydrophobic organic substances and high mineralization rates lead to low degrees of WR in cropped soils, it has been reported that conservative agricultural practices may induce soil WR. Although there are many studies at catchment, slope or plot scales very few studies have been carried out at particle or aggregate scale. Intra-aggregate heterogeneity of physical, biological and chemical properties conditions the transport of substances, microbial activity and biochemical processes, including changes in the amount, distribution and chemical properties of organic matter. Some authors have reported positive relationships between soil WR and aggregate stability, since it may delay the entry of water into aggregates, increase structural stability and contribute to reduce soil erosion risk. Organic C (OC) content, aggregate stability and WR are therefore strongly related parameters. In the case of agricultural soils, where both the type of management as crops can influence all these parameters, it is important to evaluate the interactions among them and their consequences. Studies focused on the intra-aggregate distribution of OC and WR are necessary to shed light on the soil processes at a detailed scale. It is extremely important to understand how the spatial distribution of OC in soil aggregates can protect against rapid water entry and help stabilize larger structural units or lead to preferential flow. The objectives of this research are to study [i] the OC content and the

  9. Evaluation of local electric fields generated by transcranial direct current stimulation with an extracephalic reference electrode based on realistic 3D body modeling

    NASA Astrophysics Data System (ADS)

    Im, Chang-Hwan; Park, Ji-Hye; Shim, Miseon; Chang, Won Hyuk; Kim, Yun-Hee

    2012-04-01

    In this study, local electric field distributions generated by transcranial direct current stimulation (tDCS) with an extracephalic reference electrode were evaluated to address extracephalic tDCS safety issues. To this aim, we generated a numerical model of an adult male human upper body and applied the 3D finite element method to electric current conduction analysis. In our simulations, the active electrode was placed over the left primary motor cortex (M1) and the reference electrode was placed at six different locations: over the right temporal lobe, on the right supraorbital region, on the right deltoid, on the left deltoid, under the chin, and on the right buccinator muscle. The maximum current density and electric field intensity values in the brainstem generated by the extracephalic reference electrodes were comparable to, or even less than, those generated by the cephalic reference electrodes. These results suggest that extracephalic reference electrodes do not lead to unwanted modulation of the brainstem cardio-respiratory and autonomic centers, as indicated by recent experimental studies. The volume energy density was concentrated at the neck area by the use of deltoid reference electrodes, but was still smaller than that around the active electrode locations. In addition, the distributions of elicited cortical electric fields demonstrated that the use of extracephalic reference electrodes might allow for the robust prediction of cortical modulations with little dependence on the reference electrode locations.

  10. Evaluation of local electric fields generated by transcranial direct current stimulation with an extracephalic reference electrode based on realistic 3D body modeling.

    PubMed

    Im, Chang-Hwan; Park, Ji-Hye; Shim, Miseon; Chang, Won Hyuk; Kim, Yun-Hee

    2012-04-21

    In this study, local electric field distributions generated by transcranial direct current stimulation (tDCS) with an extracephalic reference electrode were evaluated to address extracephalic tDCS safety issues. To this aim, we generated a numerical model of an adult male human upper body and applied the 3D finite element method to electric current conduction analysis. In our simulations, the active electrode was placed over the left primary motor cortex (M1) and the reference electrode was placed at six different locations: over the right temporal lobe, on the right supraorbital region, on the right deltoid, on the left deltoid, under the chin, and on the right buccinator muscle. The maximum current density and electric field intensity values in the brainstem generated by the extracephalic reference electrodes were comparable to, or even less than, those generated by the cephalic reference electrodes. These results suggest that extracephalic reference electrodes do not lead to unwanted modulation of the brainstem cardio-respiratory and autonomic centers, as indicated by recent experimental studies. The volume energy density was concentrated at the neck area by the use of deltoid reference electrodes, but was still smaller than that around the active electrode locations. In addition, the distributions of elicited cortical electric fields demonstrated that the use of extracephalic reference electrodes might allow for the robust prediction of cortical modulations with little dependence on the reference electrode locations.

  11. [Research methods of carbon sequestration by soil aggregates: a review].

    PubMed

    Chen, Xiao-Xia; Liang, Ai-Zhen; Zhang, Xiao-Ping

    2012-07-01

    To increase soil organic carbon content is critical for maintaining soil fertility and agricultural sustainable development and for mitigating increased greenhouse gases and the effects of global climate change. Soil aggregates are the main components of soil, and have significant effects on soil physical and chemical properties. The physical protection of soil organic carbon by soil aggregates is the important mechanism of soil carbon sequestration. This paper reviewed the organic carbon sequestration by soil aggregates, and introduced the classic and current methods in studying the mechanisms of carbon sequestration by soil aggregates. The main problems and further research trends in this study field were also discussed.

  12. Study of the possibility to control ion generation and transport in a high-current vacuum spark

    SciTech Connect

    Dolgov, A. N.; Zemchenkova, N. V.; Prokhorovich, D. E.

    2011-06-15

    The possibilities of optimizing a high-current vacuum spark as a source of metal ions are discussed. The influence of the shape and size of the electrodes on both the depth to which the hot plasma region is immersed in the surrounding cold matter and the plasma state in the hot spot, which is the source of multicharged ions, is demonstrated. Methods for optimization of the design of the discharge device for increasing the ion yield from a high-current vacuum spark are considered.

  13. Development of a 3D Electromagnetic Model for Eddy Current Tubing Inspection: Application to Steam Generator Tubing

    SciTech Connect

    Pichenot, G.; Premel, D.; Sollier, T.; Maillot, V.

    2004-02-26

    In nuclear plants, the inspection of heat exchanger tubes is usually carried out by using eddy current nondestructive testing. A numerical model, based on a volume integral approach using the Green's dyadic formalism, has been developed, with support from the French Institute for Radiological Protection and Nuclear Safety, to predict the response of an eddy current bobbin coil to 3D flaws located in the tube's wall. With an aim of integrating this model into the NDE multi techniques platform CIVA, it has been validated with experimental data for 2D and 3D flaws.

  14. A three-dimensional MHD simulation of the interaction of the solar wind with the earth's magnetosphere - The generation of field-aligned currents

    NASA Technical Reports Server (NTRS)

    Ogino, T.

    1986-01-01

    The time-dependent interaction of the solar wind with the earth's magnetosphere is simulated using a three-dimensional MHD model. The bow shock, magnetopause, magnetotail, and plasma sheet of the magnetosphere and Birkeland field-aligned currents that are dependent on the polarity of the z component of the IMF are produced. Twin convection cells and a dawn to dusk electric potential of 30-100 kV are detected at the equator in the magnetosphere. Four types of field-aligned currents are observed: region 1, region 2, dayside magnetopause currents in the dayside cusp region, and the dayside cusp currents for southward IMF. Region 1 and 2 field-aligned currents generated for all IMF conditions are 0.6-1.0 x 10 to the 6th A and 0.15-0.61 x 10 to the 6th A, respectively. The relationship between region 1 currents and field-aligned vorticity, and region 2 currents and pressure gradients are studied. The simulated data are compared with a theoretical analysis of the field-aligned currents and good correlation is observed.

  15. Generation of field-aligned current (FAC) and convection through the formation of pressure regimes: Correction for the concept of Dungey's convection

    NASA Astrophysics Data System (ADS)

    Tanaka, T.; Watanabe, M.; Den, M.; Fujita, S.; Ebihara, Y.; Kikuchi, T.; Hashimoto, K. K.; Kataoka, R.

    2016-09-01

    In this paper, we try to elucidate the generation mechanism of the field-aligned current (FAC) and coexisting convection. From the comparison between the theoretical prediction and the state of numerical solution from the high-resolution global simulation, we obtain the following conclusions about the distribution of dynamo, the magnetic field structure along the flow path that diverges Poynting flux, and energy conversion promoting the generation of electromagnetic energy. The dynamo for the region 1 FAC, which is in the high-latitude-side cusp-mantle region, has a structure in which magnetic field is compressed along the convection path by the slow mode motion. The dynamo for the region 2 FAC is in the ring current region at the inner edge of the plasma sheet, and has a structure in which magnetic field is curved outward along the convection path. Under these structures, electromagnetic energy is generated from the work done by pressure gradient force, in both dynamos for the region 1 and region 2 FACs. In these generation processes of the FACs, the excitation of convection and the formation of pressure regimes occur as interdependent processes. This structure leads to a modification in the way of understanding the Dungey's convection. Generation of the FAC through the formation of pressure regimes is essential even for the case of substorm onset.

  16. On the potential of using photoacoustic spectroscopy for monitoring red blood cell aggregation

    NASA Astrophysics Data System (ADS)

    Hysi, Eno; Saha, Ratan K.; Kolios, Michael C.

    2012-03-01

    In this paper we examine the potential of using photoacoustic (PA) spectroscopy for the monitoring of red blood cell (RBC) aggregation phenomena. The process of RBC aggregation has been shown to occur during periods of increased plasma fibrinogen concentration and periods of decreased blood flow (leading to diminished shear forces on the aggregates). Current techniques used to monitor RBC aggregation are invasive and do not provide an accurate assessment of the aggregation process in-vivo. We present a theoretical model for investigating the potential of PA spectroscopy for detecting and characterizing the aggregation phenomenon. We show that the signal strength increases with RBC aggregation. Experimental confirmation of the theoretical predictions is provided. Our theoretical and experimental results suggest the PA spectroscopy is capable of monitoring RBC aggregation and providing important information about changes that occur during the aggregation process as it pertains to the dynamics of aggregate formation.

  17. Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.

    PubMed

    Bourdenx, Mathieu; Koulakiotis, Nikolaos Stavros; Sanoudou, Despina; Bezard, Erwan; Dehay, Benjamin; Tsarbopoulos, Anthony

    2015-07-21

    Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative diseases that generate important health-related direct and indirect socio-economic costs. They are characterized by severe neuronal losses in several disease-specific brain regions associated with deposits of aggregated proteins. In Alzheimer's disease, β-amyloid peptide-containing plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated microtubule-associated protein tau are the two main neuropathological lesions, while Parkinson's disease is defined by the presence of Lewy Bodies that are intraneuronal proteinaceous cytoplasmic inclusions. α-Synuclein has been identified as a major protein component of Lewy Bodies and heavily implicated in the pathogenesis of Parkinson's disease. In the past few years, evidence has emerged to explain how these aggregate-prone proteins can undergo spontaneous self-aggregation, propagate from cell to cell, and mediate neurotoxicity. Current research now indicates that oligomeric forms are probably the toxic species. This article discusses recent progress in the understanding of the pathogenesis of these diseases, with a focus on the underlying mechanisms of protein aggregation, and emphasizes the pathophysiological molecular mechanisms leading to cellular toxicity. Finally, we present the putative direct link between β-amyloid peptide and tau in causing toxicity in Alzheimer's disease as well as α-synuclein in Parkinson's disease, along with some of the most promising therapeutic strategies currently in development for those incurable neurodegenerative disorders.

  18. Are ocean currents to slow to counteract SAR11 evolution? A next-generation sequencing, phylogeographic analysis.

    PubMed

    Manrique, Julieta M; Jones, Leandro R

    2017-02-01

    This work set out to shed light on the phylogeography of the SAR11 clade of Alphaproteobacteria, which is probably the most abundant group of heterotrophic bacteria on Earth. In particular, we assessed the degree to which empirical evidence (environmental DNA sequences) supports the concept that SAR11 lineages evolve faster than they are dispersed thus generating vicariant distributions, as predicted by recent simulation efforts. We generated 16S rRNA gene sequences from surface seawater collected at the South West Atlantic Ocean and combined these data with previously published sequences from similar environments from elsewhere. Altogether, these data consisted in about 1e6 reads, from which we generated 355,306 high quality sequences of which 95,318 corresponded to SAR11. Quantitative phylogeographic analyses supported the existence of a spatially explicit distribution of SAR11 species and provided evidence in favor of the idea that dispersal limitations significantly contribute to SAR11 radiation throughout the world's oceans. Likewise, pairwise phylogenetic distances between the communities studied here were significantly correlated with the genetic divergences predicted by a previously proposed neutral model. As discussed in the paper, these findings are compatible with the concept that the ocean surface constitutes a homogeneous environment for SAR11, in agreement with previous experimental data. We discuss the implications of this hypothesis in a global change scenario. This is the first study combining high throughput sequencing and phylogenic analysis to study bacterial phylogeography and reporting a distance decay pattern of phylogenetic distances for bacteria.

  19. Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

    NASA Astrophysics Data System (ADS)

    Tanase, Maya; Urbanska, Aleksandra M.; Zolla, Valerio; Clement, Cristina C.; Huang, Liling; Morozova, Kateryna; Follo, Carlo; Goldberg, Michael; Roda, Barbara; Reschiglian, Pierluigi; Santambrogio, Laura

    2016-01-01

    Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-related high molecular weight aggregates, isolated from the bone marrow and splenic cells of aging mice and followed by biochemical and mass spectrometric analysis. The analysis indicated that compared to younger mice an increase in protein post-translational carbonylation was observed. The causative role of these modifications in inducing protein misfolding and aggregation was determined by inducing carbonyl stress in young mice, which recapitulated the increased protein aggregation observed in old mice. Altogether our analysis indicates that oxidative stress-related post-translational modifications accumulate in the aging proteome and are responsible for increased protein aggregation and altered cell proteostasis.

  20. Targeting Protein Aggregation for the Treatment of Degenerative Diseases

    PubMed Central

    Eisele, Yvonne S.; Monteiro, Cecilia; Fearns, Colleen; Encalada, Sandra E.; Wiseman, R. Luke; Powers, Evan T.; Kelly, Jeffery W.

    2015-01-01

    The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, collectively called amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates. Persuasive pharmacologic and genetic evidence now support protein aggregation as the cause of post-mitotic tissue dysfunction or loss. However, a more detailed understanding of the factors that trigger and sustain aggregate formation, as well as the structure-activity relationships underlying proteotoxicity are needed to develop future disease-modifying therapies. PMID:26338154

  1. Tracking protein aggregate interactions

    PubMed Central

    Bartz, Jason C; Nilsson, K Peter R

    2011-01-01

    Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis.1, 2 At each fibril end, β-sheets provide a template for recruiting and converting monomers.3 Different amyloid fibrils often co-occur in the same individual, yet whether a protein aggregate aids or inhibits the assembly of a heterologous protein is unclear. In prion disease, diverse prion aggregate structures, known as strains, are thought to be the basis of disparate disease phenotypes in the same species expressing identical prion protein sequences.4–7 Here we explore the interactions reported to occur when two distinct prion strains occur together in the central nervous system. PMID:21597336

  2. Bed bug aggregation pheromone finally identified.

    PubMed

    Gries, Regine; Britton, Robert; Holmes, Michael; Zhai, Huimin; Draper, Jason; Gries, Gerhard

    2015-01-19

    Bed bugs have become a global epidemic and current detection tools are poorly suited for routine surveillance. Despite intense research on bed bug aggregation behavior and the aggregation pheromone, which could be used as a chemical lure, the complete composition of this pheromone has thus far proven elusive. Here, we report that the bed bug aggregation pheromone comprises five volatile components (dimethyl disulfide, dimethyl trisulfide, (E)-2-hexenal, (E)-2-octenal, 2-hexanone), which attract bed bugs to safe shelters, and one less-volatile component (histamine), which causes their arrestment upon contact. In infested premises, a blend of all six components is highly effective at luring bed bugs into traps. The trapping of juvenile and adult bed bugs, with or without recent blood meals, provides strong evidence that this unique pheromone bait could become an effective and inexpensive tool for bed bug detection and potentially their control.

  3. Zooplankton Aggregations Near Sills

    DTIC Science & Technology

    2003-09-30

    frequency echo-sounder system. This data were supplemented with multi-net (BIONESS) trawls, bongo nets, and otter trawls (operated by D. Mackas and group...side. The general composition of the zooplankton aggregations can be deduced from the relative levels of the three echo-sounder frequencies; krill ...Nov. 20th, 2002. Krill layer is evident at 66 – 90 m, coincident with BIONESS trawl through the region. 3 Figure 2 shows a comparison between

  4. Analysis of a novel autonomous marine hybrid power generation/energy storage system with a high-voltage direct current link

    NASA Astrophysics Data System (ADS)

    Wang, Li; Lee, Dong-Jing; Lee, Wei-Jen; Chen, Zhe

    This paper presents both time-domain and frequency-domain simulated results of a novel marine hybrid renewable-energy power generation/energy storage system (PG/ESS) feeding isolated loads through an high-voltage direct current (HVDC) link. The studied marine PG subsystems comprise both offshore wind turbines and Wells turbines to respectively capture wind energy and wave energy from marine wind and ocean wave. In addition to wind-turbine generators (WTGs) and wave-energy turbine generators (WETGs) employed in the studied system, diesel-engine generators (DEGs) and an aqua electrolyzer (AE) absorbing a part of generated energy from WTGs and WETGs to generate available hydrogen for fuel cells (FCs) are also included in the PG subsystems. The ES subsystems consist of a flywheel energy storage system (FESS) and a compressed air energy storage (CAES) system to balance the required energy in the hybrid PG/ESS. It can be concluded from the simulation results that the proposed hybrid marine PG/ESS feeding isolated loads can stably operate to achieve system power-frequency balance condition.

  5. Boosting current generation in microbial fuel cells by an order of magnitude by coating an ionic liquid polymer on carbon anodes.

    PubMed

    Yang, Lu; Deng, Wenfang; Zhang, Youming; Tan, Yueming; Ma, Ming; Xie, Qingji

    2017-05-15

    Microbial fuel cells (MFCs) have attracted great attentions due to their great application potentials, but the relatively low power densities of MFCs still hinder their widespread practical applications. Herein, we report that the current generation in MFCs can be boosted by an order of magnitude, simply by coating a hydrophilic and positively charged ionic liquid polymer (ILP) on carbon cloth (CC) or carbon felt (CF). The ILP coating not only can increase the bacterial loading capacity due to the electrostatic interactions between ILP and bacterial cells, but also can improve the mediated extracellular electron transfer between the electrode and the cytochrome proteins on the outer membrane of Shewanella putrefaciens cells. As a result, the maximum power density of a MFC equipped with the CF-ILP bioanode is as high as 4400±170mWm(-2), which is amongst the highest values reported to date. This work demonstrates a new strategy for greatly boosting the current generation in MFCs.

  6. The Dynomak: An advanced spheromak reactor system with imposed-dynamo current drive and next-generation nuclear power technologies

    NASA Astrophysics Data System (ADS)

    Sutherland, D. A.; Jarboe, T. R.; Marklin, G.; Morgan, K. D.; Nelson, B. A.

    2013-10-01

    A high-beta spheromak reactor system has been designed with an overnight capital cost that is competitive with conventional power sources. This reactor system utilizes recently discovered imposed-dynamo current drive (IDCD) and a molten salt blanket system for first wall cooling, neutron moderation and tritium breeding. Currently available materials and ITER developed cryogenic pumping systems were implemented in this design on the basis of technological feasibility. A tritium breeding ratio of greater than 1.1 has been calculated using a Monte Carlo N-Particle (MCNP5) neutron transport simulation. High-temperature superconducting tapes (YBCO) were used for the equilibrium coil set, substantially reducing the recirculating power fraction when compared to previous spheromak reactor studies. Using zirconium hydride for neutron shielding, a limiting equilibrium coil lifetime of at least thirty full-power years has been achieved. The primary FLiBe loop was coupled to a supercritical carbon dioxide Brayton cycle due to attractive economics and high thermal efficiencies. With these advancements, an electrical output of 1000 MW from a thermal output of 2486 MW was achieved, yielding an overall plant efficiency of approximately 40%. A paper concerning the Dynomak reactor design is currently being reviewed for publication.

  7. System performance and cost sensitivity comparisons of stretched membrane heliostat reflectors with current generation glass/metal concepts

    SciTech Connect

    Murphy, L.M.; Anderson, J.V.; Short, W.; Wendelin, T.

    1985-12-01

    Heliostat costs have long been recognized as a major factor in the cost of solar central receiver plants. Research on stretched membrane heliostats has been emphasized because of their potential as a cost-effective alternative to current glass/metal designs. However, the cost and performance potential of stretched membrane heliostats from a system perspective has not been studied until this time. The optical performance of individual heliostats is predicted here using results established in previous structural studies. These performance predictions are used to compare both focused and unfocused stretched membrane heliostats with state-of-the-art glass/metal heliostats from a systems perspective. We investigated the sensitivity of the relative cost and performance of fields of heliostats to a large number of parameter variations, including system size, delivery temperature, heliostat module size, surface specularity, hemispherical reflectance, and macroscopic surface quality. The results indicate that focused stretched membrane systems should have comparable performance levels to those of current glass/metal heliostat systems. Further, because of their relatively lower cost, stretched membrane heliostats should provide an economically attractive alternative to current glass/metal heliostats over essentially the entire range of design parameters studied. Unfocused stretched membrane heliostats may also be attractive for a somewhat more limited range of applications, including the larger plant sizes and lower delivery temperatures.

  8. Proteins aggregation and human diseases

    NASA Astrophysics Data System (ADS)

    Hu, Chin-Kun

    2015-04-01

    Many human diseases and the death of most supercentenarians are related to protein aggregation. Neurodegenerative diseases include Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), frontotemporallobar degeneration, etc. Such diseases are due to progressive loss of structure or function of neurons caused by protein aggregation. For example, AD is considered to be related to aggregation of Aβ40 (peptide with 40 amino acids) and Aβ42 (peptide with 42 amino acids) and HD is considered to be related to aggregation of polyQ (polyglutamine) peptides. In this paper, we briefly review our recent discovery of key factors for protein aggregation. We used a lattice model to study the aggregation rates of proteins and found that the probability for a protein sequence to appear in the conformation of the aggregated state can be used to determine the temperature at which proteins can aggregate most quickly. We used molecular dynamics and simple models of polymer chains to study relaxation and aggregation of proteins under various conditions and found that when the bending-angle dependent and torsion-angle dependent interactions are zero or very small, then protein chains tend to aggregate at lower temperatures. All atom models were used to identify a key peptide chain for the aggregation of insulin chains and to find that two polyQ chains prefer anti-parallel conformation. It is pointed out that in many cases, protein aggregation does not result from protein mis-folding. A potential drug from Chinese medicine was found for Alzheimer's disease.

  9. Collisional Aggregation Due to Turbulence

    NASA Astrophysics Data System (ADS)

    Pumir, Alain; Wilkinson, Michael

    2016-03-01

    Collisions between particles suspended in a fluid play an important role in many physical processes. As an example, collisions of microscopic water droplets in clouds are a necessary step in the production of macroscopic raindrops. Collisions of dust grains are also conjectured to be important for planet formation in the gas surrounding young stars and to play a role in the dynamics of sand storms. In these processes, collisions are favored by fast turbulent motions. Here we review recent advances in the understanding of collisional aggregation due to turbulence. We discuss the role of fractal clustering of particles and caustic singularities of their velocities. We also discuss limitations of the Smoluchowski equation for modeling such processes. These advances lead to a semiquantitative understanding on the influence of turbulence on collision rates and point to deficiencies in the current understanding of rainfall and planet formation.

  10. Next-generation sequencing (NGS) for assessment of microbial water quality: current progress, challenges, and future opportunities.

    PubMed

    Tan, BoonFei; Ng, Charmaine; Nshimyimana, Jean Pierre; Loh, Lay Leng; Gin, Karina Y-H; Thompson, Janelle R

    2015-01-01

    Water quality is an emergent property of a complex system comprised of interacting microbial populations and introduced microbial and chemical contaminants. Studies leveraging next-generation sequencing (NGS) technologies are providing new insights into the ecology of microbially mediated processes that influence fresh water quality such as algal blooms, contaminant biodegradation, and pathogen dissemination. In addition, sequencing methods targeting small subunit (SSU) rRNA hypervariable regions have allowed identification of signature microbial species that serve as bioindicators for sewage contamination in these environments. Beyond amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in fresh water environments reveal the genetic capabilities and interplay of waterborne microorganisms, shedding light on the mechanisms for production and biodegradation of toxins and other contaminants. This review discusses the challenges and benefits of applying NGS-based methods to water quality research and assessment. We will consider the suitability and biases inherent in the application of NGS as a screening tool for assessment of biological risks and discuss the potential and limitations for direct quantitative interpretation of NGS data. Secondly, we will examine case studies from recent literature where NGS based methods have been applied to topics in water quality assessment, including development of bioindicators for sewage pollution and microbial source tracking, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of harmful pollutants that threaten water quality. Finally, we provide a short review of emerging NGS platforms and their potential applications to the next generation of water quality assessment tools.

  11. A mobile test facility based on a magnetic cumulative generator to study the stability of the power plants under impact of lightning currents

    NASA Astrophysics Data System (ADS)

    Shurupov, A. V.; Zavalova, V. E.; Kozlov, A. V.; Shurupov, M. A.

    2016-12-01

    The report presents the results of the development and field testing of a mobile test facility based on a helical magnetic cumulative generator (MCGTF). The system is designed for full-scale modeling of lightning currents to study the safety of power plants of any type, including nuclear power plants. Advanced technologies of high-energy physics for solving both engineering and applied problems underlie this pilot project. The energy from the magnetic cumulative generator (MCG) is transferred to a high-impedance load with high efficiency of more than 50% using pulse transformer coupling. Modeling of the dynamics of the MEG that operates in a circuit with lumped parameters allows one to apply the law of inductance output during operation of the MCG, thus providing the required front of the current pulse in the load without using any switches. The results of field testing of the MCGTF are presented for both the ground loop and the model load. The ground loop generates a load resistance of 2-4 Ω. In the tests, the ohmic resistance of the model load is 10 Ω. It is shown that the current pulse parameters recorded in the resistive-inductive load are close to the calculated values.

  12. Influence of Hall Current and Viscous Dissipation on Pressure Driven Flow of Pseudoplastic Fluid with Heat Generation: A Mathematical Study.

    PubMed

    Noreen, Saima; Qasim, Muhammad

    2015-01-01

    In this paper, we study the influence of heat sink (or source) on the peristaltic motion of pseudoplastic fluid in the presence of Hall current, where channel walls are non-conducting in nature. Flow analysis has been carried out under the approximations of a low Reynolds number and long wavelength. Coupled equations are solved using shooting method for numerical solution for the axial velocity function, temperature and pressure gradient distributions. We analyze the influence of various interesting parameters on flow quantities. The present study can be considered as a mathematical presentation of the dynamics of physiological organs with stones.

  13. IgG Conformer's Binding to Amyloidogenic Aggregates

    PubMed Central

    Phay, Monichan; Welzel, Alfred T.; Williams, Angela D.; McWilliams-Koeppen, Helen P.; Blinder, Veronika; O'Malley, Tiernan T.; Solomon, Alan; Walsh, Dominic M.; O'Nuallain, Brian

    2015-01-01

    Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findings on pAb conformer's binding to amyloidogenic aggregates: 1) pAb aggregates have greater activity than monomers (HMW species > dimers > monomers), 2) pAbs interactions with amyloidogenic aggregates at least partially involves unconventional (non-CDR) interactions of F(ab) regions, and 3) pAb's activity can be easily modulated by trace aggregates generated during sample processing. Specifically, we show that HMW aggregates and dimeric pAbs present in commercial preparations of pAbs, intravenous immunoglobulin (IVIg), had up to ~200- and ~7-fold stronger binding to aggregates of Aβ and transthyretin (TTR) than the monomeric antibody. Notably, HMW aggregates were primarily responsible for the enhanced anti-amyloid activities of Aβ- and Cibacron blue-isolated IVIg IgGs. Human pAb conformer's binding to amyloidogenic aggregates was retained in normal human sera, and mimicked by murine pAbs isolated from normal pooled plasmas. An unconventional (non-CDR) component to pAb's activity was indicated from control human mAbs, generated against non-amyloid targets, binding to aggregated Aβ and TTR. Similar to pAbs, HMW and dimeric mAb conformers bound stronger than their monomeric forms to amyloidogenic aggregates. However, mAbs had lower maximum binding signals, indicating that pAbs were required to saturate a diverse collection of binding sites. Taken together, our findings strongly support further investigations on the physiological function and clinical utility of the inherent anti-amyloid activities of monomeric but not aggregated IgGs. PMID:26367058

  14. Control of energy spread and dark current in proton and ion beams generated in high-contrast laser solid interactions.

    PubMed

    Dollar, F; Matsuoka, T; Petrov, G M; Thomas, A G R; Bulanov, S S; Chvykov, V; Davis, J; Kalinchenko, G; McGuffey, C; Willingale, L; Yanovsky, V; Maksimchuk, A; Krushelnick, K

    2011-08-05

    By using temporal pulse shaping of high-contrast, short pulse laser interactions with solid density targets at intensities of 2 × 10(21) W cm(-2) at a 45° incident angle, we show that it is possible to reproducibly generate quasimonoenergetic proton and ion energy spectra. The presence of a short pulse prepulse 33 ps prior to the main pulse produced proton spectra with an energy spread between 25% and 60% (ΔE/E) with energy of several MeV, with light ions becoming quasimonoenergetic for 50 nm targets. When the prepulse was removed, the energy spectra was broad. Numerical simulations suggest that expansion of the rear-side contaminant layer allowed for density conditions that prevented the protons from being screened from the sheath field, thus providing a low energy cutoff in the observed spectra normal to the target surface.

  15. Generating high-current monoenergetic proton beams by a circularly polarized laser pulse in the phase-stable acceleration regime.

    PubMed

    Yan, X Q; Lin, C; Sheng, Z M; Guo, Z Y; Liu, B C; Lu, Y R; Fang, J X; Chen, J E

    2008-04-04

    A new ion acceleration method, namely, phase-stable acceleration, using circularly-polarized laser pulses is proposed. When the initial target density n(0) and thickness D satisfy a(L) approximately (n(0)/n(c))D/lambda(L) and D>l(s) with a(L), lambda(L), l(s), and n(c) the normalized laser amplitude, the laser wavelength in vacuum, the plasma skin depth, and the critical density of the incident laser pulse, respectively, a quasiequilibrium for the electrons is established by the light pressure and the space charge electrostatic field at the interacting front of the laser pulse. The ions within the skin depth of the laser pulse are synchronously accelerated and bunched by the electrostatic field, and thereby a high-intensity monoenergetic proton beam can be generated. The proton dynamics is investigated analytically and the results are verified by one- and two-dimensional particle-in-cell simulations.

  16. Determination of the dynamic elastic constants of recycled aggregate concrete

    NASA Astrophysics Data System (ADS)

    Tsoumani, A. A.; Barkoula, N.-M.; Matikas, T. E.

    2015-03-01

    Nowadays, construction and demolition waste constitutes a major portion of the total solid waste production in the world. Due to both environmental and economical reasons, an increasing interest concerning the use of recycled aggregate to replace aggregate from natural sources is generated. This paper presents an investigation on the properties of recycled aggregate concrete. Concrete mixes are prepared using recycled aggregates at a substitution level between 0 and 100% of the total coarse aggregate. The influence of this replacement on strengthened concrete's properties is being investigated. The properties estimated are: density and dynamic modulus of elasticity at the age of both 7 and 28 days. Also, flexural strength of 28 days specimens is estimated. The determination of the dynamic elastic modulus was made using the ultrasonic pulse velocity method. The results reveal that the existence of recycled aggregates affects the properties of concrete negatively; however, in low levels of substitution the influence of using recycled aggregates is almost negligible. Concluding, the controlled use of recycled aggregates in concrete production may help solve a vital environmental issue apart from being a solution to the problem of inadequate concrete aggregates.

  17. Method for generating linear current-field characteristics and eliminating charging delay in no-insulation superconducting magnets

    NASA Astrophysics Data System (ADS)

    Kim, Seokho; Hahn, Seungyong; Kim, Kwangmin; Larbalestier, David

    2017-03-01

    No-insulation (NI) rare-earth barium copper oxide (REBCO) magnets are promising for high field or high temperature superconducting magnets because they simplify quench protection. However, the turn-to-turn leakage current path induced by the absence of insulation introduces nonlinearities into the magnetic fieldcurrent characteristic and significant delay in reaching the desired field. This paper shows that active feedback control can mitigate both the nonlinearity and the charging delay. To verify our approach, simulations and tests were performed with an NI REBCO magnet made of 13 double-pancake coils. A proportional and integral (PI) feedback control of the power supply was adopted which allowed determination of the appropriate PI gains using dynamic simulations of the equivalent circuit of the NI magnet. Feedback control tests were then performed in liquid nitrogen at 77 K. The time to reach 99.5% of the target magnetic field to become essentially steady-state was reduced by more than 2000 times from 850 s without control to 0.4 s with control. The results demonstrate a potential that one of the most significant perceived disadvantages of an NI magnet can essentially be removed by active feedback control of the power supply current.

  18. Next-generation sequencing (NGS) for assessment of microbial water quality: current progress, challenges, and future opportunities

    PubMed Central

    Tan, BoonFei; Ng, Charmaine; Nshimyimana, Jean Pierre; Loh, Lay Leng; Gin, Karina Y.-H.; Thompson, Janelle R.

    2015-01-01

    Water quality is an emergent property of a complex system comprised of interacting microbial populations and introduced microbial and chemical contaminants. Studies leveraging next-generation sequencing (NGS) technologies are providing new insights into the ecology of microbially mediated processes that influence fresh water quality such as algal blooms, contaminant biodegradation, and pathogen dissemination. In addition, sequencing methods targeting small subunit (SSU) rRNA hypervariable regions have allowed identification of signature microbial species that serve as bioindicators for sewage contamination in these environments. Beyond amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in fresh water environments reveal the genetic capabilities and interplay of waterborne microorganisms, shedding light on the mechanisms for production and biodegradation of toxins and other contaminants. This review discusses the challenges and benefits of applying NGS-based methods to water quality research and assessment. We will consider the suitability and biases inherent in the application of NGS as a screening tool for assessment of biological risks and discuss the potential and limitations for direct quantitative interpretation of NGS data. Secondly, we will examine case studies from recent literature where NGS based methods have been applied to topics in water quality assessment, including development of bioindicators for sewage pollution and microbial source tracking, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of harmful pollutants that threaten water quality. Finally, we provide a short review of emerging NGS platforms and their potential applications to the next generation of water quality assessment tools. PMID:26441948

  19. Current collapse imaging of Schottky gate AlGaN/GaN high electron mobility transistors by electric field-induced optical second-harmonic generation measurement

    SciTech Connect

    Katsuno, Takashi Ishikawa, Tsuyoshi; Ueda, Hiroyuki; Uesugi, Tsutomu; Manaka, Takaaki; Iwamoto, Mitsumasa

    2014-06-23

    Two-dimensional current collapse imaging of a Schottky gate AlGaN/GaN high electron mobility transistor device was achieved by optical electric field-induced second-harmonic generation (EFISHG) measurements. EFISHG measurements can detect the electric field produced by carriers trapped in the on-state of the device, which leads to current collapse. Immediately after (e.g., 1, 100, or 800 μs) the completion of drain-stress voltage (200 V) in the off-state, the second-harmonic (SH) signals appeared within 2 μm from the gate edge on the drain electrode. The SH signal intensity became weak with time, which suggests that the trapped carriers are emitted from the trap sites. The SH signal location supports the well-known virtual gate model for current collapse.

  20. Influence of grid control on beam quality in laser ion source generating high-current low-charged copper ions

    SciTech Connect

    Hasegawa, J.; Yoshida, M.; Ogawa, M.; Oguri, Y.; Nakajima, M.; Horioka, K.; Kwan, J.

    2003-08-01

    We examined grid-controlled extraction for a laser ion source using a KrF laser. By using grid-controlled extraction in the over-dense regime, we found that the ion beam current waveforms were stabilized more significantly as the grid bias raised from -90 V to -280 V. The normalized emittance of 0.08 {pi}mm-mrad measured without the grid control was improved to 0.06 {pi}mm-mrad with the grid control. In contrast to this observation, the grid bias disturbed the pattern of the beam extracted in the source-limited regime. Fast extraction was carried out using a high-voltage pulse with a rise time of {approx} 100 ns. The grid control suppressed successfully the beam pedestal originating from the plasma pre-filled in the extraction gap.

  1. The influence of erythrocyte aggregation on induced platelet aggregation.

    PubMed

    Ott, C; Lardi, E; Schulzki, T; Reinhart, W H

    2010-01-01

    Red blood cells (RBCs) affect platelet aggregation in flowing blood (primary hemostasis). We tested the hypothesis that RBC aggregation could influence platelet aggregation. RBC aggregation was altered in vitro by: (i) changing plasma aggregatory properties with 3.7 g% dextran 40 (D40), 3.0 g% dextran 70 (D70) or 1.55 g% dextran 500 (D500); (ii) changing RBC aggregatory properties by incubating RBCs in 50 mU/ml neuraminidase for 60 min (reduction of the surface sialic acid content, thus reducing electrostatic repulsion) and subsequent RBC resuspension in platelet rich plasma (PRP) containing 1 g% dextran 70. RBC aggregation was assessed with the sedimentation rate (ESR). Platelet aggregation was measured: (i) in flowing whole blood with a platelet function analyzer PFA-100(R), which simulates in vivo conditions with RBCs flowing in the center and platelets along the wall, where they adhere to collagen and aggregate; and (ii) in a Chrono-log 700 Aggregometer, which measures changes of impedance by platelet aggregation in whole blood or changes in light transmission in PRP. We found that RBC aggregation increased with increasing molecular weight of dextran (ESR: 4 +/- 3 mm/h, 34 +/- 14 mm/h and 89 +/- 23 mm/hfor D40, D70 and D500, respectively, p < 0.0001) and with neuraminidase-treated RBCs (76 +/- 27 mm/h vs 27 +/- 8 mm/h, respectively, p < 0.0001). Platelet aggregation measured in whole blood under flow conditions (PFA-100) and without flow (Chronolog Aggregometer) was not affected by RBC aggregation. Our data suggest that RBC aggregation does not affect platelet aggregation in vitro and plays no role in primary hemostasis.

  2. Protein Aggregation and Its Impact on Product Quality

    PubMed Central

    Roberts, Christopher J.

    2014-01-01

    Protein pharmaceutical products are typically active as folded monomers that are composed of one or more protein chains, such as the heavy and light chains in monoclonal antibodies that are a mainstay of current drug pipelines. There are numerous possible aggregated states for a given protein, some of which are potentially useful, while most of which are considered deleterious from the perspective of pharmaceutical product quality and performance. This review provides an overview of how and why different aggregated states of proteins occur, how this potentially impacts product quality and performance, fundamental approaches to control aggregate formation, and the practical approaches that are currently used in the pharmaceutical industry. PMID:25173826

  3. Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

    PubMed

    Young, Guy; Sørensen, Benny; Dargaud, Yesim; Negrier, Claude; Brummel-Ziedins, Kathleen; Key, Nigel S

    2013-03-14

    Hemophilia is a bleeding disorder that afflicts about 1 in 5000 males. Treatment relies upon replacement of the deficient factor, and response to treatment both in clinical research and practice is based upon subjective parameters such as pain and joint mobility. Existing laboratory assays quantify the amount of factor in plasma, which is useful diagnostically and prognostically. However, these assays are limited in their ability to fully evaluate the patient's clot-forming capability. Newer assays, known as global assays, provide a far more detailed view of thrombin generation and clot formation and have been studied in hemophilia for about 10 years. They have the potential to offer a more objective measure of both the hemophilic phenotype as well as the response to treatment. In particular, in patients who develop inhibitors to deficient clotting factors and in whom bypassing agents are required for hemostasis, these assays offer the opportunity to determine the laboratory response to these interventions where traditional coagulation assays cannot. In this article we review the existing literature and discuss several controversial issues surrounding the assays. Last, a vision of future clinical uses of these assays is briefly described.

  4. Genomic Profiling of Thyroid Nodules: Current Role for ThyroSeq Next-Generation Sequencing on Clinical Decision-Making

    PubMed Central

    Kargi, Atil Y.; Bustamante, Marcela Perez; Gulec, Seza

    2017-01-01

    In recent years there has been an increased awareness of the genetic alterations underlying both benign and malignant neoplasms of the thyroid. Next-generation sequencing (NGS) is an emerging technology that allows for rapid detection of a large number of genetic mutations in thyroid fine-needle aspiration (FNA) specimens. NGS for targeted mutational analysis in thyroid tumors has been proposed as a tool to assist in the diagnosis of thyroid nodules with indeterminate FNA cytology. Results of genomic testing of thyroid nodules and thyroid cancers could also have prognostic implications and play a role in determining optimal treatment strategies including targeted therapies. We provide a critical review of existing studies assessing the performance of the ThyroSeq NGS test for the diagnosis and management of patients with thyroid nodules with indeterminate cytopathology and discuss the applicability of findings from these studies to clinical practice. While there are early indications to suggest a possible utility of data obtained from NGS to aid in prognostication and therapeutic decision-making in thyroid cancer, we recommend judicious use and cautious interpretation of such molecular testing until results of ongoing clinical trials become available. Lastly, we discuss recommendations provided from clinical practice guidelines regarding the use of mutation detection via NGS in the diagnostic evaluation of thyroid nodules. PMID:28117287

  5. Optical Sensors for Planetary Radiant Energy (OSPREy): Calibration and Validation of Current and Next-Generation NASA Missions

    NASA Technical Reports Server (NTRS)

    Hooker, Stanford B.; Bernhard, Germar; Morrow, John H.; Booth, Charles R.; Comer, Thomas; Lind, Randall N.; Quang, Vi

    2012-01-01

    A principal objective of the Optical Sensors for Planetary Radiance Energy (OSPREy) activity is to establish an above-water radiometer system as a lower-cost alternative to existing in-water systems for the collection of ground-truth observations. The goal is to be able to make high-quality measurements satisfying the accuracy requirements for the vicarious calibration and algorithm validation of next-generation satellites that make ocean color and atmospheric measurements. This means the measurements will have a documented uncertainty satisfying the established performance metrics for producing climate-quality data records. The OSPREy approach is based on enhancing commercial-off-the-shelf fixed-wavelength and hyperspectral sensors to create hybridspectral instruments with an improved accuracy and spectral resolution, as well as a dynamic range permitting sea, Sun, sky, and Moon observations. Greater spectral diversity in the ultraviolet (UV) will be exploited to separate the living and nonliving components of marine ecosystems; UV bands will also be used to flag and improve atmospheric correction algorithms in the presence of absorbing aerosols. The short-wave infrared (SWIR) is expected to improve atmospheric correction, because the ocean is radiometrically blacker at these wavelengths. This report describes the development of the sensors, including unique capabilities like three-axis polarimetry; the documented uncertainty will be presented in a subsequent report.

  6. Orthogonal cross-seeding: an approach to explore protein aggregates in living cells.

    PubMed

    Hinz, Justyna; Gierasch, Lila M; Ignatova, Zoya

    2008-04-08

    Protein aggregation is associated with the pathology of many diseases, especially neurodegenerative diseases. A variety of structurally polymorphic aggregates or preaggregates including amyloid fibrils is accessible to any aggregating protein. Preaggregates are now believed to be the toxic culprits in pathologies rather than mature aggregates. Although clearly valuable, understanding the mechanism of formation and the structural characteristics of these prefibrillar species is currently lacking. We report here a simple new approach to map the nature of the aggregate core of transient aggregated species directly in the cell. The method is conceptually based on the highly discriminating ability of aggregates to recruit new monomeric species with equivalent molecular structure. Different soluble segments comprising parts of an amyloidogenic protein were transiently pulse-expressed in a tightly controlled, time-dependent manner along with the parent aggregating full-length protein, and their recruitment into the insoluble aggregate was monitored immunochemically. We used this approach to determine the nature of the aggregate core of the metastable aggregate species formed during the course of aggregation of a chimera containing a long polyglutamine repeat tract in a bacterial host. Strikingly, we found that different segments of the full-length protein dominated the aggregate core at different times during the course of aggregation. In its simplicity, the approach is also potentially amenable to screen also for compounds that can reshape the aggregate core and induce the formation of alternative nonamyloidogenic species.

  7. Structure of Viral Aggregates

    NASA Astrophysics Data System (ADS)

    Barr, Stephen; Luijten, Erik

    2010-03-01

    The aggregation of virus particles is a particular form of colloidal self-assembly, since viruses of a give type are monodisperse and have identical, anisotropic surface charge distributions. In small-angle X-ray scattering experiments, the Qbeta virus was found to organize in different crystal structures in the presence of divalent salt and non-adsorbing polymer. Since a simple isotropic potential cannot explain the occurrence of all observed phases, we employ computer simulations to investigate how the surface charge distribution affects the virus interactions. Using a detailed model of the virus particle, we find an asymmetric ion distribution around the virus which gives rise to the different phases observed.

  8. Subthreshold amplitude and phase resonance in models of quadratic type: nonlinear effects generated by the interplay of resonant and amplifying currents.

    PubMed

    Rotstein, Horacio G

    2015-04-01

    We investigate the biophysical and dynamic mechanisms of generation of subthreshold amplitude and phase resonance in response to sinusoidal input currents in two-dimensional models of quadratic type. These models feature a parabolic voltage nullcline and a linear nullcline for the recovery gating variable, capturing the interplay of the so-called resonant currents (e.g., hyperpolarization-activated mixed-cation inward and slow potassium) and amplifying currents (e.g., persistent sodium) in biophysically realistic parameter regimes. These currents underlie the generation of resonance in medial entorhinal cortex layer II stellate cells and CA1 pyramidal cells. We show that quadratic models exhibit nonlinear amplifications of the voltage response to sinusoidal inputs in the resonant frequency band. These are expressed as an increase in the impedance profile as the input amplitude increases. They are stronger for values positive than negative to resting potential and are accompanied by a shift in the phase profile, a decrease in the resonant and phase-resonant frequencies, and an increase in the sharpness of the voltage response. These effects are more prominent for smaller values of ∊ (larger levels of the time scale separation between the voltage and the resonant gating variable) and for values of the resting potential closer to threshold for spike generation. All other parameter fixed, as ∊ increases the voltage response becomes "more linear"; i.e., the nonlinearities are present, but "ignored". In addition, the nonlinear effects are strongly modulated by the curvature of the parabolic voltage nullcline (partially reflecting the effects of the amplifying current) and the slope of the resonant current activation curve. Following the effects of changes in the biophysical conductances of realistic conductance-based models through the parameters of the quadratic model, we characterize the qualitatively different effects that resonant and amplifying currents have on

  9. MX Siting Investigation. Geotechnical Evaluation. Aggregate Resources Study, Lake Valley, Nevada.

    DTIC Science & Technology

    1981-02-27

    use of aggregate material for asphaltic concrete, base course in road construction, or ballast material. However, many of the suitability tests for...ranged from 5 to 14 feet (1.5 to 4.3 m). While the Verification stud - ies are not specifically designed- to generate aggregate data, the sampling...AGGREGATE CHARACTERISTIC’LSI CASU CASI ABRASION RESISTANCE. PERCENT WEAR 2 អ អ >50 No S04 12 --12 --12 COARSE AGGREGATE SOUNDNESS, M O 1 1

  10. Aggregation and vertical migration behavior of Euphausia superba

    NASA Astrophysics Data System (ADS)

    Zhou, Meng; Dorland, Ryan D.

    2004-08-01

    Aggregation and vertical migration behavior of Euphausia superba were studied in Marguerite Bay and its vicinity west of the Antarctic Peninsula using a vessel-mounted, Acoustic Doppler Current Profiler, and a Multiple Opening and Closing Nets and Environmental Sensing System, during the 2001 and 2002 fall US Southern Ocean GLOBEC project cruises. The kinematics of aggregation behavior of E. superba associated with diel migration is studied using observations of their abundance and swimming velocities: during the day, E. superba reduce their swimming at a depth of 250 m; and at night, they swim randomly at their cruising speed in the upper part of an aggregation near the surface, and coherently as schooling in the lower part of an aggregation. The causes for the aggregation behavior and vertical migration of krill are explored by examining the relationship with ice coverage and presence of predators. The motion of euphausiids is further analyzed in terms of kinetic energy and force balance, leading to new considerations of mathematical theories and models of aggregation behavior. The results show a diel variation of the energy demand for maintaining their locomotion. The horizontal scale of an aggregation is studied in conjunction with horizontal gradients of currents. Results indicate that the swimming capability of euphausiids determines the maintenance of an aggregation in the mesoscale circulation field.

  11. Which nurseries currently care for ventilated neonates in Illinois and Wisconsin? Implications for the next generation of perinatal regionalization.

    PubMed

    Meadow, William; Kim, Mijung; Mendez, David; Bell, Anthony; Gray, Cathy; Corpuz, Maria; Lantos, John

    2002-05-01

    We were interested in the extent to which advances in the availability of neonatalogy expertise have provided a centrifugal impetus to perinatal care. Specifically, we wondered where infants who were sick enough to require mechanical ventilation were currently being managed. We surveyed 116 of 140 hospitals in Illinois and Wisconsin that offered obstetric/newborn services in 1998-1999. The 23 Level I nurseries were consistently small, and offered virtually no "advanced" neonatal intensive care unit (NICU) technology. The 16 Level III NICUs were consistently large, offered advanced technology and personnel, and received sick infants from many hospitals in their regional network. The 77 Level II nurseries (two thirds of all hospitals with newborn services) were less consistently characterized. In general, Level II nurseries were a "spoke" (not a hub), and did not offer extracorporeal-membrane oxygenation (ECMO), nitric oxide (NO), or cardiovascular (CV) surgery. However, 19 (25%) of 77 Level II centers self-designated as "Level II+". These were significantly more likely to offer ventilators, percutaneous central venous catheters (PCVCs), total parenteral nutrition (TPN), and surgery. Fifty-three percent (18/34) of all nurseries offering mechanical ventilation self-designated as a Level II or II+, as opposed to Level III. Facile inferences about the appropriate role of Level II centers derived from decades-old data are probably unsupportable. It is time to acknowledge the distinction between the Level II nursery of the past and the newly evolving Level II+ NICUs.

  12. Generation of postured voxel-based human models for the study of step voltage excited by lightning current

    NASA Astrophysics Data System (ADS)

    Gao, J.; Munteanu, I.; Müller, W. F. O.; Weiland, T.

    2011-07-01

    With the development of medical technique and computational electromagnetics, high resolution anatomic human models have already been widely developed and used in computation of electromagnetic fields induced in human body. Although these so called voxel-based human models are powerful tools for research on electromagnetic safety, their unchangeable standing posture makes it impossible to simulate a realistic scenario in which people have a lot of different postures. This paper describes a poser program package which was developed as an improved version of the free-from deformation technique to overcome this problem. It can set rotation angles of different human joints and then deform the original human model to make it have different postures. The original whole-body human model can be deformed smoothly, continuity of internal tissues and organs is maintained and the mass of different tissues and organs can be conserved in a reasonable level. As a typical application of the postured human models, this paper also studies the effect of the step voltage due to a lightning strike on the human body. Two voxel-based human body models with standing and walking posture were developed and integrated into simulation models to compute the current density distribution in the human body shocked by the step voltage. In order to speed up the transient simulation, the reduced c technique was used, leading to a speedup factor of around 20. The error introduced by the reduced c technique is discussed and simulation results are presented in detail.

  13. Refining aggregate exposure: example using parabens.

    PubMed

    Cowan-Ellsberry, Christina E; Robison, Steven H

    2009-12-01

    The need to understand and estimate quantitatively the aggregate exposure to ingredients used broadly in a variety of product types continues to grow. Currently aggregate exposure is most commonly estimated by using a very simplistic approach of adding or summing the exposures from all the individual product types in which the chemical is used. However, the more broadly the ingredient is used in related consumer products, the more likely this summation will result in an unrealistic estimate of exposure because individuals in the population vary in their patterns of product use including co-use and non-use. Furthermore the ingredient may not be used in all products of a given type. An approach is described for refining this aggregate exposure using data on (1) co-use and non-use patterns of product use, (2) extent of products in which the ingredient is used and (3) dermal penetration and metabolism. This approach and the relative refinement in the aggregate exposure from incorporating these data is illustrated using methyl, n-propyl, n-butyl and ethyl parabens, the most widely used preservative system in personal care and cosmetic products. When these refining factors were used, the aggregate exposure compared to the simple addition approach was reduced by 51%, 58%, 90% and 92% for methyl, n-propyl, n-butyl and ethyl parabens, respectively. Since biomonitoring integrates all sources and routes of exposure, the estimates using this approach were compared to available paraben biomonitoring data. Comparison to the 95th percentile of these data showed that these refined estimates were still conservative by factors of 2-92. All of our refined estimates of aggregate exposure are less than the ADI of 10mg/kg/day for parabens.

  14. Hot moments in spawning aggregations: implications for ecosystem-scale nutrient cycling

    NASA Astrophysics Data System (ADS)

    Archer, Stephanie K.; Allgeier, Jacob E.; Semmens, Brice X.; Heppell, Scott A.; Pattengill-Semmens, Christy V.; Rosemond, Amy D.; Bush, Phillippe G.; McCoy, Croy M.; Johnson, Bradley C.; Layman, Craig A.

    2015-03-01

    Biogeochemical hot moments occur when a temporary increase in availability of one or more limiting reactants results in elevated rates of biogeochemical reactions. Many marine fish form transient spawning aggregations, temporarily increasing their local abundance and thus nutrients supplied via excretion at the aggregation site. In this way, nutrients released by aggregating fish could create a biogeochemical hot moment. Using a combination of empirical and modeling approaches, we estimate nitrogen and phosphorus supplied by aggregating Nassau grouper ( Epinephelus striatus). Data suggest aggregating grouper supply up to an order-of-magnitude more nitrogen and phosphorus than daily consumer-derived nutrient supply on coral reefs without aggregating fish. Comparing current and historic aggregation-level excretion estimates shows that overfishing reduced nutrients supplied by aggregating fish by up to 87 %. Our study illustrates a previously unrecognized ecosystem viewpoint regarding fish spawning aggregations and provides an additional perspective on the repercussions of their overexploitation.

  15. Electrochemical selection and characterization of a high current-generating Shewanella oneidensis mutant with altered cell-surface morphology and biofilm-related gene expression

    PubMed Central

    2014-01-01

    Background Shewanella oneidensis MR-1 exhibits extracellular electron transfer (EET) activity that is influenced by various cellular components, including outer-membrane cytochromes, cell-surface polysaccharides (CPS), and regulatory proteins. Here, a random transposon-insertion mutant library of S. oneidensis MR-1 was screened after extended cultivation in electrochemical cells (ECs) with a working electrode poised at +0.2 V (vs. Ag/AgCl) to isolate mutants that adapted to electrode-respiring conditions and identify as-yet-unknown EET-related factors. Results Several mutants isolated from the enrichment culture exhibited rough morphology and extraordinarily large colonies on agar plates compared to wild-type MR-1. One of the isolated mutants, designated strain EC-2, produced 90% higher electric current than wild-type MR-1 in ECs and was found to have a transposon inserted in the SO_1860 (uvrY) gene, which encodes a DNA-binding response regulator of the BarA/UvrY two-component regulatory system. However, an in-frame deletion mutant of SO_1860 (∆SO_1860) did not exhibit a similar level of current generation as that of EC-2, suggesting that the enhanced current-generating capability of EC-2 was not simply due to the disruption of SO_1860. In both EC-2 and ∆SO_1860, the transcription of genes related to CPS synthesis was decreased compared to wild-type MR-1, suggesting that CPS negatively affects current generation. In addition, transcriptome analyses revealed that a number of genes, including those involved in biofilm formation, were differentially expressed in EC-2 compared to those in ∆SO_1860. Conclusions The present results indicate that the altered expression of the genes related to CPS biosynthesis and biofilm formation is associated with the distinct morphotype and high current-generating capability of strain EC-2, suggesting an important role of these genes in determining the EET activity of S. oneidensis. PMID:25028134

  16. Aggregate and Heatmap Representations of Genome-Wide Localization Data Using VAP, a Versatile Aggregate Profiler.

    PubMed

    Brunelle, Mylène; Coulombe, Charles; Poitras, Christian; Robert, Marc-Antoine; Markovits, Alexei Nordell; Robert, François; Jacques, Pierre-Étienne

    2015-01-01

    In the analysis of experimental data corresponding to the signal enrichment of chromatin features such as histone modifications throughout the genome, it is often useful to represent the signal over known regions of interest, such as genes, using aggregate or individual profiles. In the present chapter, we describe and explain the best practices on how to generate such profiles as well as other usages of the versatile aggregate profiler (VAP) tool (Coulombe et al., Nucleic Acids Res 42:W485-W493, 2014), with a particular focus on the new functionalities introduced in version 1.1.0 of VAP.

  17. Statistical, economic and other tools for assessing natural aggregate

    USGS Publications Warehouse

    Bliss, J.D.; Moyle, P.R.; Bolm, K.S.

    2003-01-01

    Quantitative aggregate resource assessment provides resource estimates useful for explorationists, land managers and those who make decisions about land allocation, which may have long-term implications concerning cost and the availability of aggregate resources. Aggregate assessment needs to be systematic and consistent, yet flexible enough to allow updating without invalidating other parts of the assessment. Evaluators need to use standard or consistent aggregate classification and statistic distributions or, in other words, models with geological, geotechnical and economic variables or interrelationships between these variables. These models can be used with subjective estimates, if needed, to estimate how much aggregate may be present in a region or country using distributions generated by Monte Carlo computer simulations.

  18. Acoustic spin pumping: Direct generation of spin currents from sound waves in Pt/Y3Fe5O12 hybrid structures

    NASA Astrophysics Data System (ADS)

    Uchida, K.; Adachi, H.; An, T.; Nakayama, H.; Toda, M.; Hillebrands, B.; Maekawa, S.; Saitoh, E.

    2012-03-01

    Using a Pt/Y3Fe5O12 (YIG) hybrid structure attached to a piezoelectric actuator, we demonstrate the generation of spin currents from sound waves. This "acoustic spin pumping" (ASP) is caused by the sound wave generated by the piezoelectric actuator, which then modulates the distribution function of magnons in the YIG layer and results in a pure-spin-current injection into the Pt layer across the Pt/YIG interface. In the Pt layer, this injected spin current is converted into an electric voltage due to the inverse spin-Hall effect (ISHE). The ISHE induced by the ASP is detected by measuring a voltage in the Pt layer at the piezoelectric resonance frequency of the actuator coupled with the Pt/YIG system. The frequency-dependent measurements enable us to separate the ASP-induced signals from extrinsic heating effects. Our model calculation based on the linear response theory provides us with a qualitative and quantitative understanding of the ASP in the Pt/YIG system.

  19. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.

    PubMed

    Kyle, Barry D; Bradley, Eamonn; Large, Roddy; Sergeant, Gerard P; McHale, Noel G; Thornbury, Keith D; Hollywood, Mark A

    2013-09-15

    We used the perforated patch-clamp technique at 37°C to investigate the mechanisms underlying the activation of a transient large-conductance K(+) (tBK) current in rabbit urethral smooth muscle cells. The tBK current required an elevation of intracellular Ca(2+), resulting from ryanodine receptor (RyR) activation via Ca(2+)-induced Ca(2+) release, triggered by Ca(2+) influx through L-type Ca(2+) (CaV) channels. Carbachol inhibited tBK current by reducing Ca(2+) influx and Ca(2+) release and altered the shape of spike complexes recorded under current-clamp conditions. The tBK currents were blocked by iberiotoxin and penitrem A (300 and 100 nM, respectively) and were also inhibited when external Ca(2+) was removed or the CaV channel inhibitors nifedipine (10 μM) and Cd(2+) (100 μM) were applied. The tBK current was inhibited by caffeine (10 mM), ryanodine (30 μM), and tetracaine (100 μM), suggesting that RyR-mediated Ca(2+) release contributed to the activation of the tBK current. When IP3 receptors (IP3Rs) were blocked with 2-aminoethoxydiphenyl borate (2-APB, 100 μM), the amplitude of the tBK current was not reduced. However, when Ca(2+) release via IP3Rs was evoked with phenylephrine (1 μM) or carbachol (1 μM), the tBK current was inhibited. The effect of carbachol was abolished when IP3Rs were blocked with 2-APB or by inhibition of muscarinic receptors with the M3 receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (1 μM). Under current-clamp conditions, bursts of action potentials could be evoked with depolarizing current injection. Carbachol reduced the number and amplitude of spikes in each burst, and these effects were reduced in the presence of 2-APB. In the presence of ryanodine, the number and amplitude of spikes were also reduced, and carbachol was without further effect. These data suggest that IP3-generating agonists can modulate the electrical activity of rabbit urethral smooth muscle cells and may contribute to the effects of

  20. Dielectric approach to investigation of erythrocyte aggregation. II. Kinetics of erythrocyte aggregation-disaggregation in quiescent and flowing blood.

    PubMed

    Pribush, A; Meiselman, H J; Meyerstein, D; Meyerstein, N

    2000-01-01

    A method based on dielectric properties of dispersed systems was applied to investigate the kinetics of RBC aggregation and the break-up of the aggregates. Experimentally, this method consists of measuring the capacitance at a frequency in the beginning of the beta-dispersion. Two experimental protocols were used to investigate the aggregation process. In the first case, blood samples were fully dispersed and then the flow was decreased or stopped to promote RBC aggregation. It was found that the initial phases of RBC aggregation are not affected by the shear rate. This finding indicates that RBC aggregation is a slow coagulation process. In the second case, RBCs aggregated under flow conditions at different shear rates and after the capacitance reached plateau levels, the flow was ceased. The steady-state capacitance of the quiescent blood and the kinetics of RBC aggregation after stoppage of shearing depend on the prior shear rate. To clarify the reasons for this effect, the kinetics of the disaggregation process was studied. In these experiments, time courses of the capacitance were recorded under different flow conditions and then a higher shear stress was applied to break up RBC aggregates. It was found that the kinetics of the disaggregation process depend on both the prior and current shear stresses. Results obtained in this study and their analysis show that the kinetics of RBC aggregation in stasis consists of two consecutive phases: At the onset, red blood cells interact face-to-face to form linear aggregates and then, after an accumulation of an appropriate concentration of these aggregates, branched rouleaux are formed via reactions of ends of the linear rouleaux with sides of other rouleaux (face-to-side interactions). Branching points are broken by low shear stresses whereas dispersion of the linear rouleaux requires significantly higher energy.