Science.gov

Sample records for aging hhs action

  1. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... prescribed in § 93.501, the ORI finding of research misconduct is the final HHS action on the research... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct...

  2. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Institutional... and the requirements of this part may result in enforcement action against the institution. (b) ORI... reprimand. (2) Direct that research misconduct proceedings be handled by HHS. (3) Place the institution...

  3. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in § 93.501, the ORI finding of research misconduct is the final HHS action on the...

  4. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS actions. 93.406 Section 93.406 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...

  5. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in § 93.501, the ORI finding of research misconduct is the final HHS action on the...

  6. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of...

  7. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  8. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  9. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  10. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in § 93.501, the ORI finding of research misconduct is the final HHS action on the...

  11. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a settlement or finding of... 42 Public Health 1 2010-10-01 2010-10-01 false Final HHS action with no settlement or finding...

  12. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Mitigating and aggravating factors in HHS administrative actions. 93.408 Section 93.408 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  13. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS action with no settlement or finding of research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  14. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement...

  15. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Mitigating and aggravating factors in HHS administrative actions. 93.408 Section 93.408 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  16. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement...

  17. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement...

  18. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  19. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS action with settlement or finding of research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  20. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  1. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  2. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  3. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Mitigating and aggravating factors in HHS... and Human Services Research Misconduct Issues § 93.408 Mitigating and aggravating factors in HHS... conserve public funds. HHS considers aggravating and mitigating factors in determining appropriate...

  4. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  5. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  6. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Notifying the respondent of findings of research misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC...

  7. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  8. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.408 Mitigating and aggravating factors in HHS... the misconduct have significant impact on the proposed or reported research record, research...

  9. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.408 Mitigating and aggravating factors in HHS... the misconduct have significant impact on the proposed or reported research record, research...

  10. The HHS Mandate and Religious Liberty: A Primer

    ERIC Educational Resources Information Center

    Keim, Adele Auxier

    2013-01-01

    "We are in a war," Health and Human Services Secretary Kathleen Sebelius declared to cheers at a 2011 National Abortion and Reproductive Rights Action League (NARAL) Pro-Choice America fund-raiser. Secretary Sebelius was referring in part to the uproar caused by the "HHS Mandate," her agency's rule that employer-provided…

  11. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Pursuant to 5 CFR 2635.203(a), each of the twelve components of HHS listed below is designated as an agency... agencies for purposes of applying any provision of 5 CFR part 2635 or this part to employees of the remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency...

  12. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Pursuant to 5 CFR 2635.203(a), each of the twelve components of HHS listed below is designated as an agency... agencies for purposes of applying any provision of 5 CFR part 2635 or this part to employees of the remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency...

  13. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Pursuant to 5 CFR 2635.203(a), each of the twelve components of HHS listed below is designated as an agency... agencies for purposes of applying any provision of 5 CFR part 2635 or this part to employees of the remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency...

  14. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  15. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  16. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  17. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  18. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  19. 78 FR 73195 - Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching Program Match No. 1312 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer...

  20. 78 FR 49525 - Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY:...

  1. Resources for the Aging: An Action Handbook.

    ERIC Educational Resources Information Center

    National Council on the Aging, Inc., New York, NY.

    This handbook on resources for the aging lists nationwide, federally sponsored programs, national voluntary agencies and associations, and foundations; it includes information on the nature and purpose of the program, types of projects sponsored, and extent of assistance, eligibility requirements, available printed information, sources of further…

  2. 45 CFR 91.16 - Affirmative action by recipient.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Affirmative action by recipient. 91.16 Section 91.16 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination §...

  3. Teachers' Pedagogical Reasoning and Action in the Digital Age

    ERIC Educational Resources Information Center

    Starkey, Louise

    2010-01-01

    Beginning teachers are entering the profession with increasing confidence in their ability to use digital technologies which has the potential to change the way teachers of the future make pedagogical decisions. This paper explores how pedagogical reasoning and action might occur in the digital age, comparing Schulman's 1987 model with the reality…

  4. Patricia Hartge Receives the HHS Career Achievement Award

    Cancer.gov

    In February 2012, Patricia Hartge, Sc.D., Deputy Director of DCEG’s Epidemiology and Biostatistics Program, received the Department of Health and Human Services (HHS) Career Achievement Award at the HHS Honor Awards Ceremony.

  5. 48 CFR 302.7100 - HHS standard templates and formats.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false HHS standard templates and formats. 302.7100 Section 302.7100 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL DEFINITIONS OF WORDS AND TERMS HHS Standard Templates and Formats 302.7100 HHS standard...

  6. 48 CFR 302.7100 - HHS standard templates and formats.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false HHS standard templates and formats. 302.7100 Section 302.7100 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL DEFINITIONS OF WORDS AND TERMS HHS Standard Templates and Formats 302.7100 HHS standard...

  7. Mobility and Aging: New Directions for Public Health Action

    PubMed Central

    Guralnik, Jack M.; Jackson, Richard J.; Marottoli, Richard A.; Phelan, Elizabeth A.; Prohaska, Thomas R.

    2012-01-01

    Optimal mobility, defined as relative ease and freedom of movement in all of its forms, is central to healthy aging. Mobility is a significant consideration for research, practice, and policy in aging and public health. We examined the public health burdens of mobility disability, with a particular focus on leading public health interventions to enhance walking and driving, and the challenges and opportunities for public health action. We propose an integrated mobility agenda, which draws on the lived experience of older adults. New strategies for research, practice, and policy are needed to move beyond categorical promotion programs in walking and driving to establish a comprehensive program to enhance safe mobility in all its forms. PMID:22698013

  8. Effects of Aging on Evoked Retrusive Tongue Actions

    PubMed Central

    Becker, Benjamin J.; Russell, John A.; Connor, Nadine P.

    2015-01-01

    Objective Tongue strength, timing, and coordination deficits may underlie age-related swallowing function. Retrusive tongue actions are likely important in retrograde bolus transport. However, age-related changes in retrusive tongue muscle contractile properties have not been identified in animal studies. Because previous studies employed whole hypoglossal nerve stimulation that activated both protrusive and retrusive tongue muscles, co-contraction may have masked retrusive muscle force decrements. The hypotheses of this study were: (1) retrusive tongue muscle contraction forces would be diminished and temporal characteristics prolonged in old rats when lateral nerves were selectively activated, and (2) greater muscle contractile forces with selective lateral branch stimulation would be found relative to whole hypoglossal nerve stimulation. Design Nineteen Fischer 344/Brown Norway rats (9 Old, 10 Young Adult) underwent tongue muscle contractile property recording elicited by: (1) bilateral whole hypoglossal nerve stimulation, and (2) selective lateral branch stimulation. Twitch contraction time (CT), half-decay time, maximal twitch and tetanic forces, and a fatigue index were measured. Results For whole nerve stimulation, CT was significantly longer in the old group. No significant age group differences were found with selective lateral nerve stimulation. Significantly reduced twitch forces (old group only), increased tetanic forces and significantly less fatigue were found with selective lateral nerve stimulation than with whole hypoglossal stimulation. Conclusions Retrusive tongue forces are not impaired in old rats. Deficits observed in swallowing with aging may be due to other factors such as inadequate bolus propulsive forces, mediated by protrusive tongue muscles, or timing/coordination of muscle actions. PMID:25847069

  9. Five Years of HHS Home Health Care Evaluations: Using Evaluation to Change National Policy

    ERIC Educational Resources Information Center

    Brandon, Paul R.; Smith, Nick L.; Grob, George F.

    2012-01-01

    In 1997, American Evaluation Association member George Grob, now retired from the U.S. Department of Health and Human Services (HHS) and currently President of the Center for Public Program Evaluation, made a testimony on Medicare home health care fraud and abuse before the U.S. Senate Special Committee on Aging. The occasion was to announce the…

  10. Rhetoric to action: a study of stakeholder perceptions of aging well in two local communities.

    PubMed

    Everingham, Jo-Anne; Lui, Chi-Wai; Bartlett, Helen; Warburton, Jeni; Cuthill, Michael

    2010-11-01

    This qualitative study of local perceptions of policy goals and action in relation to aging reports 31 stakeholder interviews within 2 Australian communities exploring (a) the meaning of aging well; and (b) preferred policy actions to achieve positive aging outcomes. Findings suggest that community perceptions of aging well are broadly consistent with the goals of national and international policy frameworks in focusing on 3 dimensions--health, social engagement, and security. Further, participants believe that achievement of positive aging outcomes requires a mix of self-help, community action, and government intervention--particularly government support and encouragement for aging well initiatives. PMID:20972930

  11. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Additional HHS training requirements. 301.603-73 Section 301.603-73 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and...

  12. 77 FR 4034 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  13. 78 FR 5182 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  14. 76 FR 3637 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... was delayed, as described at 75 FR 45628. However, the level of the 2011 poverty guidelines presented... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in...

  15. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2011-10-01 2011-10-01 false Adoption of HHS regulations. 605.0 Section...

  16. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2010-10-01 2010-10-01 false Adoption of HHS regulations. 605.0 Section...

  17. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2014-10-01 2014-10-01 false Adoption of HHS regulations. 605.0 Section...

  18. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2013-10-01 2013-10-01 false Adoption of HHS regulations. 605.0 Section...

  19. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2012-10-01 2012-10-01 false Adoption of HHS regulations. 605.0 Section...

  20. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7 Other HHS regulations that apply. Several...

  1. 78 FR 56706 - HHS Retrospective Review 2013 Request for Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... ideas using the Federal eRulemaking Portal, please visit http://www.regulations.gov and follow the... that would be appropriate for review. See 76 FR 32330 (June 6, 2011). HHS has made significant progress... administration or regulatory burdens. To learn more about regulatory activity at HHS, please visit...

  2. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  3. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  4. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  5. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  6. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  7. The timing and precision of action prediction in the aging brain.

    PubMed

    Diersch, Nadine; Jones, Alex L; Cross, Emily S

    2016-01-01

    Successful social interactions depend on the ability to anticipate other people's actions. Current conceptualizations of brain function propose that causes of sensory input are inferred through their integration with internal predictions generated in the observer's motor system during action observation. Less is known concerning how action prediction changes with age. Previously we showed that internal action representations are less specific in older compared with younger adults at behavioral and neural levels. Here, we characterize how neural activity varies while healthy older adults aged 56-71 years predict the time-course of an unfolding action as well as the relation to task performance. By using fMRI, brain activity was measured while participants observed partly occluded actions and judged the temporal coherence of the action continuation that was manipulated. We found that neural activity in frontoparietal and occipitotemporal regions increased the more an action continuation was shifted backwards in time. Action continuations that were shifted towards the future preferentially engaged early visual cortices. Increasing age was associated with neural activity that extended from posterior to anterior regions in frontal and superior temporal cortices. Lower sensitivity in action prediction resulted in activity increases in the caudate. These results imply that the neural implementation of predicting actions undergoes similar changes as the neural process of executing actions in older adults. The comparison between internal predictions and sensory input seems to become less precise with age leading to difficulties in anticipating observed actions accurately, possibly due to less specific internal action models. PMID:26503586

  8. 75 FR 28023 - Solicitation of Written Comments on Draft HHS Strategic Framework on Multiple Chronic Conditions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... HUMAN SERVICES Solicitation of Written Comments on Draft HHS Strategic Framework on Multiple Chronic... on Multiple Chronic Conditions draft ``HHS Strategic Framework on Multiple Chronic Conditions.'' DATES: Comments on the HHS Interagency Workgroup on Multiple Chronic Conditions draft...

  9. Cross-Age Peer Mentoring. Research in Action. Issue 7

    ERIC Educational Resources Information Center

    Karcher, Michael

    2007-01-01

    Cross-age peer mentoring is a somewhat unique and different approach to mentoring than the better-known adult-with-youth mentoring model. In cross-age mentoring programs (CAMPs) the mentor is an older youth, typically high school-aged, who is paired or matched with an elementary or middle school-aged child. Meetings almost always take place in the…

  10. [The Canadian Institute of Aging: knowledge, innovation and action].

    PubMed

    Rosa, Sophie

    2006-03-01

    Led by innovation, leadership, transparency and excellence, the Institute of Aging provides a focal point for Canadian research on aging and pursues the fundamental goal of advancing knowledge in the field of aging to improve the quality of life and health of older Canadians. The Institute has carried out a range of important national and international strategic initiatives in aging, and has become influential in leveraging funding, enhancing research capacity and creating a new impetus in research on aging in Canada. The Institute engages and supports the scientific community, encourages interdisciplinary and integrative health research and fosters not only on the creation of new knowledge, but also on the translation of that knowledge into improved health, a strengthened health care system, and new health products and services for Canadians. The IA focuses on five priority areas of research: healthy and successful aging, biological mechanisms of aging, cognitive impairment in aging, aging and maintenance of autonomy, and finally, health services and policies relating to older people. The efforts of the IA are guided by five strategic orientations: to lead in the development and definition of strategic directions for Canadian research on aging ; to build research capacity in the field of aging ; to foster the dissemination, transfer and translation of research findings in policies, interventions, services and products ; to promote the importance of, and the need for, a research community in aging ; and to develop and support capacity-building and strategic research initiatives in the field of aging. PMID:16527218

  11. Age, Action Orientation, and Self-Regulation during the Pursuit of a Dieting Goal.

    PubMed

    Hennecke, Marie; Freund, Alexandra M

    2016-03-01

    Two studies tested the hypotheses that (1) action orientation (vs. state orientation) is positively correlated with age across adulthood and (2) action orientation aids the self-regulation of one's feelings, thoughts, and behavior during the pursuit of a dieting goal. Hypotheses were partly confirmed. In Study 1, N = 126 overweight women (age: 19-77 years) intended to lose weight by means of a low-calorie diet. In Study 2, N = 322 adults (age: 18-82 years) reported on their action orientation to replicate the association of age and action orientation found in Study 1. Study 2 corroborated only the expected positive association of age and decision-related action orientation. In Study 1, decision-related action orientation predicted higher affective well-being during the diet as well as less self-reported deviations from the diet; failure-related action orientation predicted lower levels of rumination in response to dieting failures. Action orientation partially mediated the negative effects of age on deviations and rumination (see Hennecke & Freund, ). Weight loss was not predicted by action orientation. We discuss action orientation as one factor of increased motivational competence in older adulthood. PMID:26711052

  12. Anticipatory Action Planning Increases from 3 to 10 Years of Age in Typically Developing Children

    ERIC Educational Resources Information Center

    Jongbloed-Pereboom, Marjolein; Nijhuis-van der Sanden, Maria W. G.; Saraber-Schiphorst, Nicole; Craje, Celine; Steenbergen, Bert

    2013-01-01

    The primary aim of this study was to assess the development of action planning in a group of typically developing children aged 3 to 10 years (N = 351). The second aim was to assess reliability of the action planning task and to relate the results of the action planning task to results of validated upper limb motor performance tests. Participants…

  13. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48 CFR..., correction, or retraction of the research record. (2) Letters of reprimand. (3) Imposition of...

  14. Does Causal Action Facilitate Causal Perception in Infants Younger than 6 Months of Age?

    ERIC Educational Resources Information Center

    Rakison, David H.; Krogh, Lauren

    2012-01-01

    Previous research has established that infants are unable to perceive causality until 6 1/4 months of age. The current experiments examined whether infants' ability to engage in causal action could facilitate causal perception prior to this age. In Experiment 1, 4 1/2-month-olds were randomly assigned to engage in causal action experience via…

  15. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... have been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria..., and Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the...

  16. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... have been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria..., and Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the...

  17. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria are...) Genetic Elements, Recombinant and/or Synthetic Nucleic Acids, and Recombinant and/or Synthetic...

  18. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... have been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria..., and Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the...

  19. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria are...) Genetic Elements, Recombinant and/or Synthetic Nucleic Acids, and Recombinant and/or Synthetic...

  20. Age-related macular degeneration: Complement in action.

    PubMed

    van Lookeren Campagne, Menno; Strauss, Erich C; Yaspan, Brian L

    2016-06-01

    The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD. PMID:26742632

  1. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

    SciTech Connect

    Nagai, Rhoji; Murray, David B.; Metz, Thomas O.; Baynes, John

    2012-03-01

    Advanced glycation or glycoxidation end-products (AGE) increase in tissue proteins with age, and their rate of accumulation is increased in diabetes, nephropathy and inflammatory diseases. AGE inhibitors include a range of compounds that are proposed to act by trapping carbonyl and dicarbonyl intermediates in AGE formation. However, some among the newer generation of AGE inhibitors lack reactive functional groups that would trap reaction intermediates, indicating an alternative mechanism of action. We propose that AGE inhibitors function primarily as chelators, inhibiting metal-catalyzed oxidation reactions. The AGE-inhibitory activity of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers is also consistent with their chelating activity. Finally, compounds described as AGE breakers, or their hydrolysis products, also have strong chelating activity, suggesting that these compounds also act through their chelating activity. We conclude that chelation is the common, and perhaps the primary, mechanism of action of AGE inhibitors and breakers, and that chronic, mild chelation therapy should prove useful in treatment of diabetes and age-related diseases characterized by oxidative stress, inflammation and increased chemical modification of tissue proteins by advanced glycoxidation and lipoxidation end-products.

  2. Critical action research applied in clinical placement development in aged care facilities.

    PubMed

    Xiao, Lily D; Kelton, Moira; Paterson, Jan

    2012-12-01

    The aim of this study was to develop quality clinical placements in residential aged care facilities for undergraduate nursing students undertaking their nursing practicum topics. The proportion of people aged over 65 years is expected to increase steadily from 13% in 2006 to 26% of the total population in Australia in 2051. However, when demand is increasing for a nursing workforce competent in the care of older people, studies have shown that nursing students generally lack interest in working with older people. The lack of exposure of nursing students to quality clinical placements is one of the key factors contributing to this situation. Critical action research built on a partnership between an Australian university and five aged care organisations was utilised. A theoretical framework informed by Habermas' communicative action theory was utilised to guide the action research. Multiple research activities were used to support collaborative critical reflection and inform actions throughout the action research. Clinical placements in eight residential aged care facilities were developed to support 179 nursing students across three year-levels to complete their practicum topics. Findings were presented in three categories described as structures developed to govern clinical placement, learning and teaching in residential aged care facilities. PMID:23134277

  3. Age, sex, and pubertal phase influence mentalizing about emotions and actions in adolescents.

    PubMed

    Keulers, Esther H H; Evers, Elisabeth A T; Stiers, Peter; Jolles, Jelle

    2010-01-01

    This study examined (1) emotional versus cognitive developmental trajectories and (2) the influence of age-extrinsic factors (i.e., sex and puberty). Using a cross-sectional design, adolescents (N = 252) divided into four age-groups (ages 13, 15, 17, 19) performed two versions of a mentalizing task, about emotions and actions, as well as the Tower task. First, performance on all tasks improved linearly into late adolescence (age 19). Thus no differential trajectories were found for emotional versus cognitive development. Second, girls outperformed boys in mentalizing speed regarding both emotions and actions. In boys, a later pubertal phase was associated with increased mentalizing speed after controlling for age-group. PMID:20721775

  4. 29 CFR 1614.407 - Civil action: Title VII, Age Discrimination in Employment Act and Rehabilitation Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Civil action: Title VII, Age Discrimination in Employment... Actions § 1614.407 Civil action: Title VII, Age Discrimination in Employment Act and Rehabilitation Act. A... has filed a claim for individual relief pursuant to a class complaint is authorized under title...

  5. 12 CFR 268.406 - Civil action: Title VII, Age Discrimination in Employment Act and Rehabilitation Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Civil action: Title VII, Age Discrimination in... Equal Employment Opportunity Commission § 268.406 Civil action: Title VII, Age Discrimination in... complaint is authorized under title VII, the ADEA and the Rehabilitation Act to file a civil action in...

  6. 42 CFR 1007.21 - Other applicable HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Other applicable HHS regulations. 1007.21 Section... as otherwise provided in this part, the following regulations from 45 CFR subtitle A apply to grants... Procedure for Hearings Under 45 CFR part 80; Part 84—Nondiscrimination on the Basis of Handicap in...

  7. 45 CFR 156.606 - HHS audit authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false HHS audit authority. 156.606 Section 156.606 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES...

  8. 45 CFR 156.606 - HHS audit authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false HHS audit authority. 156.606 Section 156.606 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES...

  9. 42 CFR 50.607 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... education, hospitals, other nonprofit organizations, and commercial organizations 45 CFR part 79—Program...: 2 CFR part 376—Nonprocurement debarment and suspension (HHS) 42 CFR part 50, subpart D—Public Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  10. 42 CFR 50.607 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... fraud civil remedies 45 CFR part 92—Uniform administrative requirements for grants and cooperative...: 2 CFR part 376—Nonprocurement debarment and suspension (HHS) 42 CFR part 50, subpart D—Public Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  11. 42 CFR 50.607 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... fraud civil remedies 45 CFR part 92—Uniform administrative requirements for grants and cooperative...: 2 CFR part 376—Nonprocurement debarment and suspension (HHS) 42 CFR part 50, subpart D—Public Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  12. 42 CFR 50.607 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... fraud civil remedies 45 CFR part 92—Uniform administrative requirements for grants and cooperative...: 2 CFR part 376—Nonprocurement debarment and suspension (HHS) 42 CFR part 50, subpart D—Public Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  13. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities... administration of any contract to which earned value management (EVM) is applied pursuant to 334.201(a) or (b) must successfully complete an EVM training course before they commence administration of the...

  14. HHS announces Text4Health task force recommendations

    Cancer.gov

    Today, the U.S. Department of Health and Human Services (HHS) announced new recommendations to support health text messaging and mobile health (mHealth) programs. The department has been actively exploring means to capitalize on the rapid proliferation of

  15. 42 CFR 87.9 - Which other HHS regulations apply?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND HEALTH RESEARCH AND RELATED ACTIVITIES NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH... Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board... 42 Public Health 1 2011-10-01 2011-10-01 false Which other HHS regulations apply? 87.9 Section...

  16. 42 CFR 87.9 - Which other HHS regulations apply?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AND HEALTH RESEARCH AND RELATED ACTIVITIES NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH... Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board... 42 Public Health 1 2013-10-01 2013-10-01 false Which other HHS regulations apply? 87.9 Section...

  17. 42 CFR 87.9 - Which other HHS regulations apply?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AND HEALTH RESEARCH AND RELATED ACTIVITIES NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH... Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board... 42 Public Health 1 2010-10-01 2010-10-01 false Which other HHS regulations apply? 87.9 Section...

  18. 42 CFR 87.9 - Which other HHS regulations apply?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... AND HEALTH RESEARCH AND RELATED ACTIVITIES NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH... Health Service grant appeals procedure 45 CFR part 16—Procedures of the Departmental Grant Appeals Board... 42 Public Health 1 2012-10-01 2012-10-01 false Which other HHS regulations apply? 87.9 Section...

  19. Debarment, suspension, and ineligibility of contractors--HHS. Proposed rule.

    PubMed

    1984-06-14

    The Office of the Secretary, Department of Health and Human Services, is proposing to amend the HHS Acquisition Regulation by adding a new subpart concerning debarment, suspension, and ineligibility of contractors. This new subpart will implement the provisions of Subpart 9.4, Debarment, Suspension and Ineligibility, of the Federal Acquisition Regulation. PMID:10266832

  20. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false FAC-C and HHS SAC certification requirements. 301.603-72 Section 301.603-72 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 301.603-72 FAC-C and HHS...

  1. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  2. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  3. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  4. 78 FR 32255 - HHS-Operated Risk Adjustment Data Validation Stakeholder Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ...This notice announces a public meeting on the Affordable Care Act HHS-operated risk adjustment data validation process. The purpose of this public meeting is to provide opportunity to discuss the HHS risk adjustment data validation process that will be conducted when HHS operates the risk adjustment program on behalf of a state under the Affordable Care Act. The meeting will provide......

  5. One Department Serving Rural America: HHS Rural Task Force Report to the Secretary.

    ERIC Educational Resources Information Center

    Department of Health and Human Services, Washington, DC.

    In 2001, the Department of Health and Human Services (HHS) created a rural task force to develop strategies to improve HHS services in rural communities. Fifteen HHS agencies have programs serving rural communities; child- and education-related programs provide child welfare services, Head Start, health promotion and prevention services, training…

  6. Age-related differences in task goal processing strategies during action cascading.

    PubMed

    Stock, Ann-Kathrin; Gohil, Krutika; Beste, Christian

    2016-06-01

    We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this question in a systems neurophysiological study using EEG and source localization in healthy older adults and employing mathematical constraints to determine the strategy applied. The results suggest that older adults seem to apply a less efficient strategy when cascading different actions. Compared to younger adults, older adults seem to struggle to hierarchically organize their actions, which leads to an inefficient and more parallel processing of different task goals. On a systems level, the observed deficit is most likely due to an altered processing of task goals at the response selection level (P3 ERP) and related to changes of neural processes in the temporo-parietal junction. PMID:26025200

  7. Age-associated changes of insulin action on the hydrolysis of diacylglycerol generated from phosphatidic acid.

    PubMed

    Pasquaré, S J; Salvador, G A; Giusto, N M

    2006-07-01

    Age-related changes in insulin action on diacylglycerol (DAG) degradation was studied in rat cerebral cortex synaptosomes. The generation of monoacylglycerol (MAG) and water soluble products (WSP, glycerol plus glycerol-3-phosphate) from DAG was studied in cerebral cortex (CC) synaptosomes from adult (4-month-old) and aged (28-month-old) rats. Additionally, the effect of porcine insulin and tyrosine phosphorylation was evaluated in the same group of animals. In this study we demonstrate that the age-related increase in WSP generation was accompanied by unmodified MAG levels. In the presence of diacylglycerol lipase (DAG lipase) inhibitor, RHC-80267, a lower inhibitory effect on MAG production was observed in CC synaptosomes from aged rats with respect to that in adult membranes. Under these experimental conditions, WSP formation was only diminished in aged membranes. Insulin stimulated MAG and WSP formation at long incubation times (30 min) in adult animals, while it had an inhibitory effect in aged animals. Insulin plus vanadate (as tyrosine-phosphatase inhibitor) inhibited MAG production at short incubation times whereas the same effect was observed in aged animals at long times of incubation. WSP formation was stimulated by insulin plus vanadate both in adult and aged animals at 30 min of incubation. Our results show that insulin differentially modulates MAG and WSP production from exogenous PA in CC synaptosomes from aged rats compared with adult rats. PMID:16651016

  8. Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

    PubMed

    Muzumdar, Radhika; Ma, Xiaohui; Atzmon, Gil; Vuguin, Patricia; Yang, Xiaoman; Barzilai, Nir

    2004-02-01

    While the incidence of diabetes increases with age, a decrease in beta-cell function independent of age-related insulin resistance has not been conclusively determined. We studied insulin secretion (by hyperglycemic clamp) in 3-, 9-, and 20-month-old chronically catheterized, awake, Sprague Dawley (SD) rats (n = 78). Insulin action was modulated in a group of old rats by caloric restriction (CR) or by surgical removal of visceral fat (VF-). During the first 2 h of the clamp (11 mmol/l glucose), insulin secretion and insulin resistance (S(i hyper clamp)) demonstrated the characteristic hyperbolic relationship. However, after hyperglycemia for an additional 2 h, the ability to maintain insulin secretion, commensurate with the degree of insulin resistance, was decreased in all aging rats (P < 0.05). Increasing plasma glucose levels to 18 mmol/l glucose, after clamp at 11 mmol/l, increased insulin secretion by approximately threefold in young rats, but failed to induce similar magnitude of response in the aging rats ( approximately 50%). However, elevation of plasma free fatty acid (FFA) levels by twofold (by intralipid infusion during 11 mmol/l glucose clamp) resulted in a robust, approximate twofold response in both young and old rats. Thus, prolonged stimulation by hyperglycemia unveiled a functional defect in insulin secretion with aging. This age-related defect is independent of insulin action and is specific to glucose and not FFAs. We suggest that prolonged hyperglycemic stimulation can be a tool to identify functional defects in insulin secretion, particularly in the context of the hyperbolic relationship with insulin action, in elderly subjects or those at risk for type 2 diabetes. PMID:14747296

  9. Testing principle working mechanisms of the health action process approach for subjective physical age groups.

    PubMed

    Wienert, Julian; Kuhlmann, Tim; Fink, Sebastian; Hambrecht, Rainer; Lippke, Sonia

    2016-01-01

    This study investigated differences in social-cognitive predictors and self-regulatory planning, as proposed by the health action process approach (HAPA), across three different subjective physical age groups for physical activity. With a cross-sectional design, 521 participants across the chronological age span from 25 to 86 years (M = 48.79; SD = 12.66) were separated into three groups: those who feel physically younger than they are in terms of chronological age, the same perceived and chronological age, and feeling physically older compared to their chronological age. Participants were assessed regarding their perceived vulnerability, outcome expectancies, general intentions, planning, self-efficacy, and stages of physical activity (non-intenders, intenders, and actors). Data were analysed via mean comparison and multigroup structural equation modelling. Mean differences for all but one construct were eminent in all groups, generally showing that those feeling physically younger also report better social-cognitive predictors of physical activity (e.g. lower perceived vulnerability) in comparison to those who feel the same age or older. The model showed that basic working mechanisms of the HAPA can be applied to all groups. With that, the results provide for the first time evidence that principle working mechanism of the HAPA can be applied to all subjective physical age groups. These may be used to tailor health promoting interventions according to participants' needs as a more suitable proxy than chronological age. PMID:26967593

  10. Aging-Related Dysfunction of Striatal Cholinergic Interneurons Produces Conflict in Action Selection.

    PubMed

    Matamales, Miriam; Skrbis, Zala; Hatch, Robert J; Balleine, Bernard W; Götz, Jürgen; Bertran-Gonzalez, Jesus

    2016-04-20

    For goal-directed action to remain adaptive, new strategies are required to accommodate environmental changes, a process for which parafascicular thalamic modulation of cholinergic interneurons in the striatum (PF-to-CIN) appears critical. In the elderly, however, previously acquired experience frequently interferes with new learning, yet the source of this effect has remained unexplored. Here, combining sophisticated behavioral designs, cell-specific manipulation, and extensive neuronal imaging, we investigated the involvement of the PF-to-CIN pathway in this process. We found functional alterations of this circuit in aged mice that were consistent with their incapacity to update initial goal-directed learning, resulting in faulty activation of projection neurons in the striatum. Toxicogenetic ablation of CINs in young mice reproduced these behavioral and neuronal defects, suggesting that age-related deficits in PF-to-CIN function reduce the ability of older individuals to resolve conflict between actions, likely contributing to impairments in adaptive goal-directed action and executive control in aging. VIDEO ABSTRACT. PMID:27100198

  11. [European innovation partnership on active and healthy aging: moving from policy to action].

    PubMed

    García Lizana, Francisca

    2013-01-01

    Demographic change and aging are a common challenge in Europe. The rising number of elderly people will need support at home, and will consume more healthcare services, putting further pressure on the welfare system. Collaborative, integrated and people-centered care provision, whether in hospitals, homes or in the community, is a way forward to sustainable and efficient care systems. Innovative treatments to address chronic diseases and the functional decline of older people will enable them to live longer in better health and with a better quality of life. To fully unleash the potential of aging in the European Union, the European Commission -within its Innovation Union policy- launched the first European Innovation Partnership on Active and Healthy Ageing (EIP AHA). Promoting engagement and partnerships among all stakeholders in the healthcare chain is essential. This article describes the theoretical foundations, the development and expectations of the initiative, and its first actions. PMID:23140981

  12. Reasons, assessments and actions taken: sex and age differences in uses of Internet health information.

    PubMed

    Ybarra, Michele; Suman, Michael

    2008-06-01

    The Internet is transforming the way in which consumers approach their health care needs. Sex and age are influential aspects of one's health as well as disease risk and are thus integral components of the emerging picture of health information seekers. Using data from Surveying the Digital Future, Year 4, a nationally representative, longitudinal telephone survey of Americans 12 years of age and older (n = 2010), we examine the reasons for, assessments of and actions taken as a result of health information found online among men and women and older and younger people. Although we tend to think of the Internet as a young person's technology, the percent of adults 60 years of age and older is similar to that of adolescents using the Internet as a health care information resource, thus suggesting an untapped opportunity with online interventions for older adults. Nonetheless, as age increases so too does the report of frustration with the experience. Men are more likely to report a positive seeking experience than women. Differences in Internet use fail to explain these observed sex and age differences in the seeking experience. Across the spectrum of age, sex and Internet skill, Internet health information seeking appears to enhance the patient-provider relationship. PMID:16880222

  13. The HHS-HCC Risk Adjustment Model for Individual and Small Group Markets under the Affordable Care Act

    PubMed Central

    Kautter, John; Pope, Gregory C; Ingber, Melvin; Freeman, Sara; Patterson, Lindsey; Cohen, Michael; Keenan, Patricia

    2014-01-01

    Beginning in 2014, individuals and small businesses are able to purchase private health insurance through competitive Marketplaces. The Affordable Care Act (ACA) provides for a program of risk adjustment in the individual and small group markets in 2014 as Marketplaces are implemented and new market reforms take effect. The purpose of risk adjustment is to lessen or eliminate the influence of risk selection on the premiums that plans charge. The risk adjustment methodology includes the risk adjustment model and the risk transfer formula. This article is the second of three in this issue of the Review that describe the Department of Health and Human Services (HHS) risk adjustment methodology and focuses on the risk adjustment model. In our first companion article, we discuss the key issues and choices in developing the methodology. In this article, we present the risk adjustment model, which is named the HHS-Hierarchical Condition Categories (HHS-HCC) risk adjustment model. We first summarize the HHS-HCC diagnostic classification, which is the key element of the risk adjustment model. Then the data and methods, results, and evaluation of the risk adjustment model are presented. Fifteen separate models are developed. For each age group (adult, child, and infant), a model is developed for each cost sharing level (platinum, gold, silver, and bronze metal levels, as well as catastrophic plans). Evaluation of the risk adjustment models shows good predictive accuracy, both for individuals and for groups. Lastly, this article provides examples of how the model output is used to calculate risk scores, which are an input into the risk transfer formula. Our third companion paper describes the risk transfer formula. PMID:25360387

  14. The HHS-HCC risk adjustment model for individual and small group markets under the Affordable Care Act.

    PubMed

    Kautter, John; Pope, Gregory C; Ingber, Melvin; Freeman, Sara; Patterson, Lindsey; Cohen, Michael; Keenan, Patricia

    2014-01-01

    Beginning in 2014, individuals and small businesses are able to purchase private health insurance through competitive Marketplaces. The Affordable Care Act (ACA) provides for a program of risk adjustment in the individual and small group markets in 2014 as Marketplaces are implemented and new market reforms take effect. The purpose of risk adjustment is to lessen or eliminate the influence of risk selection on the premiums that plans charge. The risk adjustment methodology includes the risk adjustment model and the risk transfer formula. This article is the second of three in this issue of the Review that describe the Department of Health and Human Services (HHS) risk adjustment methodology and focuses on the risk adjustment model. In our first companion article, we discuss the key issues and choices in developing the methodology. In this article, we present the risk adjustment model, which is named the HHS-Hierarchical Condition Categories (HHS-HCC) risk adjustment model. We first summarize the HHS-HCC diagnostic classification, which is the key element of the risk adjustment model. Then the data and methods, results, and evaluation of the risk adjustment model are presented. Fifteen separate models are developed. For each age group (adult, child, and infant), a model is developed for each cost sharing level (platinum, gold, silver, and bronze metal levels, as well as catastrophic plans). Evaluation of the risk adjustment models shows good predictive accuracy, both for individuals and for groups. Lastly, this article provides examples of how the model output is used to calculate risk scores, which are an input into the risk transfer formula. Our third companion paper describes the risk transfer formula. PMID:25360387

  15. The limits of attention for visual perception and action in aging.

    PubMed

    Lee, Tung-Yu; Hsieh, Shulan

    2009-05-01

    This study aimed to investigate whether aging results in an increased attentional blink effect in older adults as compared to young adults. A rapid serial visual presentation (RSVP) paradigm was employed in which participants were asked to identify two targets (dual-task condition) presented in rapid succession. These targets were separated by various intervals in a stream of stimuli. The performance for identifying the second target was normally diminished as compared to identification of a single-task target. Various combinations of tasks, such as two perceptual tasks or one perceptual and one action task, as well as different types of pointing action, such as pointing to a displaced target, pointing to a stationary target or pointing to a disappeared target, were manipulated in this study to see if aging may further impact these variables. The results of this study showed that in young adults, successful identification of the first target interfered with identifying the second target, as well as the initiation time (action planning) of pointing to the second target. However, identification of the first target did not interfere with pointing movement time and pointing accuracy, even when the target was displaced, which required online control of action. Conversely, for older adults, successful central identification not only interfered with identifying the second target and with the pointing initiation time, but also interfered with pointing movement time for a displaced target. This suggests that older adults seem to be unable to concurrently identify the first target and correct their already-initiated pointing movement compared to young adults. PMID:19301162

  16. Study on Interactions between the Major Apple Valsa Canker Pathogen Valsa mali and Its Biocontrol Agent Saccharothrix yanglingensis Hhs.015 Using RT-qPCR.

    PubMed

    Fan, Dongying; Li, Yanfang; Zhao, Lingyun; Li, Zhengpeng; Huang, Lili; Yan, Xia

    2016-01-01

    The mechanism of biocontrol agent Saccharothrix yanglingensis Hhs.015 action against Valsa mali, a major apple Valsa canker pathogen, was examined using a novel, sensitive (minimum detection limit 100 pg/μL) and reliably RT-qPCR technique. Prior to lesion formation, total concentration of V. mali in the bark showed a significant decrease (p<0.05) after 24 h of Hhs.015 treatment. This was more pronounced at 48 and 96 h post treatment. After lesion formation, levels of V. mali remained constant at the boundary between infected and uninfected bark tissues, although the relative expansion rate of the lesion was significantly reduced (p<0.05). Gene expression levels of endo-polygalacturonase, a marker for fungal pathogenicity, were sharply reduced while host induced resistance callose synthase levels increased significantly (p<0.05) at the boundary bark at 9 d after Hhs.015 treatment. The results showed that biocontrol agent Hhs.015 prevented infection of V. mali by inhibiting pathogen growth, down-regulating pathogenicity factor expression and inducing a high level of host resistance. PMID:27611855

  17. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false FAC-C and HHS SAC certification requirements. 301.603-72 Section 301.603-72 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority,...

  18. 75 FR 45628 - Delayed Update of the HHS Poverty Guidelines for the Remainder of 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... HUMAN SERVICES Office of the Secretary Delayed Update of the HHS Poverty Guidelines for the Remainder of... delayed update of the Department of Health and Human Services (HHS) poverty guidelines for the remainder of 2010, and until the 2011 poverty guidelines are published, which is expected to occur in...

  19. 75 FR 3734 - 2009 HHS Poverty Guidelines Extended Until March 1, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... published in the Federal Register (74 FR 4199) on January 23, 2009, shall remain in effect until the... HUMAN SERVICES Office of the Secretary 2009 HHS Poverty Guidelines Extended Until March 1, 2010 AGENCY... Human Services (HHS) poverty guidelines will remain in effect until updated 2010 poverty guidelines...

  20. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... to employees for the first time at a department or agency.) (c) The FAC-C certification is based on... Training and Certification Handbook. (d) HHS SAC certification is based on three sets of requirements... the HHS Contracting Workforce Training and Certification Handbook....

  1. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... to employees for the first time at a department or agency.) (c) The FAC-C certification is based on... Training and Certification Handbook. (d) HHS SAC certification is based on three sets of requirements... the HHS Contracting Workforce Training and Certification Handbook....

  2. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to employees for the first time at a department or agency.) (c) The FAC-C certification is based on... Training and Certification Handbook. (d) HHS SAC certification is based on three sets of requirements... the HHS Contracting Workforce Training and Certification Handbook....

  3. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false HHS criteria for requesting books, documents, and... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PROGRAM INTEGRITY: MEDICARE Access to Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and...

  4. 45 CFR 158.607 - Factors HHS uses to determine the amount of penalty.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Factors HHS uses to determine the amount of penalty. 158.607 Section 158.607 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Federal Civil Penalties § 158.607 Factors HHS uses...

  5. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  6. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  7. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  8. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  9. City Initiatives in School-Age Child Care. SACC Action Research Paper No. 1. School-Age Child Project.

    ERIC Educational Resources Information Center

    Gannett, Ellen

    Features contributing to the success of six city-wide, comprehensive school-age program models are highlighted. Models are Seattle, Washington's Community Partnerships for School-Age Child Care; Madison, Wisconsin's School-Age Child Care Project; Irvine, California's Irvine Child Care Project; Houston, Texas' After-School Partnership; Los Angeles,…

  10. 45 CFR 153.270 - HHS audits of State-operated reinsurance programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT State Standards Related to the Reinsurance Program § 153.270 HHS audits of...

  11. Ready, aim, litigate. AHA takes feds to court to stop HHS from eliminating Medicaid loophole.

    PubMed

    Lovern, Ed

    2002-03-11

    The American Hospital Association and several other groups are doing their best to stop HHS from eliminating the upper payment limit loophole, and the AHA is even suing HHS, but time is running out for the payment plan worth $27 billion over the next 10 years to State Medicaid programs. This is only the fourth time in the past decade that the AHA has sued the federal government. PMID:11923969

  12. INCENTIVES TO IDENTIFY: RACIAL IDENTITY IN THE AGE OF AFFIRMATIVE ACTION

    PubMed Central

    Antman, Francisca; Duncan, Brian

    2016-01-01

    We link data on racial self-identification with changes in state-level affirmative action policies to ask whether racial self-identification responds to economic incentives. We find that after a state bans affirmative action, multiracial individuals who face an incentive to identify under affirmative action are about 30 percent less likely to identify with their minority groups. In contrast, multiracial individuals who face a disincentive to identify under affirmative action are roughly 20 percent more likely to identify with their minority groups once affirmative action policies are banned.

  13. Thermoclastic and cryoclastic action on calcareous building stone: durability to artificial ageing

    NASA Astrophysics Data System (ADS)

    Germinario, Luigi; Andriani, Gioacchino Francesco; Laviano, Rocco

    2014-05-01

    were petrographically characterized through optical microscopy on thin section, followed by a geotechnical parameterization with petrophysical measurements (dry density, total porosity, MIP porosity) and indirect ultrasonic and sclerometric tests. Then, after every 20 ageing cycles, the same tests stated above were carried out; in addition, the measurement of residual strains and SEM observations were performed. With this methodology, the gradual modifications in fabric, petrophysical and mechanical properties of the tested stone were analyzed. The results revealed a high durability of the material to the conditions of ageing experimented. The main modifications of the samples concerned fabric, i.e. microcracking due to thermoclastic and cryoclastic action, which occurred only in limited areas for an uneven distribution of internal stresses. For this reason, no evident effects on the macroscopic integrity and physico-mechanical performance were noted, whereas the stone almost preserved the original strength and elasticity. Finally, the data gathered were used to suggest a method for the evaluation of the vulnerability of "pietra gentile" to freeze-thaw microcracking, based on the peculiar porosimetric distribution and the environmental conditions of weathering. New information are globally provided about a stone material that has been largely used in the Apulian monumental heritage, but has received scarce attention from the archaeometric research so far.

  14. "What If? As If", An Approach to Action Research Practice: Becoming-Different in School-Age Childcare

    ERIC Educational Resources Information Center

    Kane, Eva

    2015-01-01

    When doing research, or for that matter working in school-age childcare, the researcher/teacher is required to develop a plan for her/his work in spite of knowing that unexpected things will happen. This article aims to explore the relationship between the process of planning and unexpected events in childcare practice and action research. The…

  15. The Functional Organization of Preschool-Age Children’s Emotion Expressions and Actions in Challenging Situations

    PubMed Central

    Dennis, Tracy A.; Cole, Pamela M.; Wiggins, Crystal N.; Cohen, Laura H.; Zalewski, Maureen

    2010-01-01

    Although functional links between emotion and action are implied in emotion regulation research, there is limited evidence that specific adaptive actions for coping with a challenge are more probable when certain negative emotions are expressed. The current study examined this question among 3- and 4-year-olds (N = 113; M age = 47.84 months, SD = 6.19). Emotion expressions and actions were observed during 2 challenging tasks: children waited for a gift while the mother worked, and children worked alone to retrieve a prize from a locked box with the wrong key. Angry and happy expressions, compared with sad expressions, were associated with more actions. These actions varied with the nature of the task, reflecting appreciation of situational appropriateness. In addition, when waiting with the mother, happiness was associated with the broadest range of actions, whereas when working alone on the locked box, anger was associated with the broadest range of actions. Results are discussed in terms of the adaptive function of negative emotions and in terms of functional and dimensional models of emotion. Findings have implications for the development of emotion regulation and social–emotional competence. PMID:19653775

  16. From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes

    PubMed Central

    Byun, Hae-Ok; Lee, Young-Kyoung; Kim, Jeong-Min; Yoon, Gyesoon

    2015-01-01

    Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies. [BMB Reports 2015; 48(10): 549-558] PMID:26129674

  17. Ten commandments for the future of ageing research in the UK: a vision for action

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Increases in longevity resulting from improvements in health care and living conditions together with a decrease in fertility rates have contributed to a shift towards an aged population profile. For the first time the UK has more people over age 60 than below 16 years of age. The increase in longev...

  18. School-Age Child Care: An Action Manual for the 90s and Beyond. Second Edition.

    ERIC Educational Resources Information Center

    Seligson, Michelle; Allenson, Michael

    Evidence suggests that self-care among school-age children has significant costs to the children, in the form of increased fearfulness and loneliness, heightened vulnerability to peer pressure, and greater likelihood of substance abuse. In response to the need for quality school-age care, this book serves as a guide for anyone wanting to implement…

  19. No Time to Waste: An Action Agenda for School-Age Child Care.

    ERIC Educational Resources Information Center

    Seligson, Michelle; Fink, Dale Borman

    This book for persons interested in setting up high quality school-age child care (SACC) programs: (1) provides background information and a rationale; (2) describes a collaborative model of program development; (3) discusses program funding and resources; (4) considers approaches to recognizing high quality school-age child care; and (5) offers…

  20. Green Team Recognized with HHS Green Champion Award Honorable Mention | Poster

    Cancer.gov

    Courtesy of the NCI at Frederick Green Team The NCI at Frederick Green Team received a Department of Health and Human Services (HHS) Green Champion Award honorable mention in June for the team’s plant swap initiative, begun in October 2012.  “The Green Team has been doing a great job this past year, and it is wonderful that their efforts have been recognized by the HHS through the Green Champion Awards,” said Craig Reynolds, Ph.D., director of the NCI Office of Scientific Operations (OSO). 

  1. Teachers for the Global Age: A Call to Action for Funders

    ERIC Educational Resources Information Center

    Devlin-Foltz, Betsy

    2010-01-01

    This postscript commentary challenges private and public funders to take action in support of the internationalization of teacher preparation programs by funding efforts for much needed resources, in order to prepare twenty-first-century teachers to teach with global perspectives. Specific ideas for foundations, corporate philanthropy, and…

  2. Microglia in action: how aging and injury can change the brain’s guardians

    PubMed Central

    Lourbopoulos, Athanasios; Ertürk, Ali; Hellal, Farida

    2015-01-01

    Neuroinflammation, the inflammatory response in the central nervous system (CNS), is a major determinant of neuronal function and survival during aging and disease progression. Microglia, as the resident tissue-macrophages of the brain, provide constant support to surrounding neurons in healthy brain. Upon any stress signal (such as trauma, ischemia, inflammation) they are one of the first cells to react. Local and/or peripheral signals determine microglia stress response, which can vary within a continuum of states from beneficial to detrimental for neuronal survival, and can be shaped by aging and previous insults. In this review, we discuss the roles of microglia upon an ischemic or traumatic injury, and give our perspective how aging may contribute to microglia behavior in the injured brain. We speculate that a deeper understanding of specific microglia identities will pave the way to develop more potent therapeutics to treat the diseases of aging brain. PMID:25755635

  3. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career...

  4. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career...

  5. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations..., Contracting Authority, and Responsibilities 301.603-74 Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C certification, all warranted Contracting Officers, regardless of series,...

  6. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations..., Contracting Authority, and Responsibilities 301.603-74 Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C certification, all warranted Contracting Officers, regardless of series,...

  7. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career...

  8. A model for antagonistic pleiotropic gene action for mortality and advanced age.

    PubMed

    Toupance, B; Godelle, B; Gouyon, P H; Schächter, F

    1998-06-01

    Association or linkage studies involving control and long-lived populations provide information on genes that influence longevity. However, the relationship between allele-specific differences in survival and the genetic structure of aging cohorts remains unclear. We model a heterogeneous cohort comprising several genotypes differing in age-specific mortality. In its most general form, without any specific assumption regarding the shape of mortality curves, the model permits derivation of a fundamental property underlying abrupt age-related changes in the composition of a cohort. The model is applied to sex-specific survival curves taken from period life tables, and Gompertz-Makeham mortality coefficients are calculated for the French population. Then, adjustments are performed under Gompertz-Makeham mortality functions for three genotypes composing a heterogeneous cohort, under the constraint of fitting the resultant mortality to the real French population mortality obtained from life tables. Multimodal curves and divergence after the 8th decade appear as recurrent features of the frequency trajectories. Finally, a fit to data previously obtained at the angiotensin-converting-enzyme locus is realized, explaining what had seemed to be paradoxical results-namely, that the frequency of a genotype known as a cardiovascular risk factor was increased in centenarians. Our results help explain the well-documented departure from Gompertz-Makeham mortality kinetics at older ages. The implications of our model are discussed in the context of known genetic effects on human longevity and age-related pathologies. Since antagonistic pleiotropy between early and late survival emerges as a general rule, extrapolating the effects measured for a gene in a particular age class to other ages could be misleading. PMID:9585593

  9. GH-related and extra-endocrine actions of GH secretagogues in aging.

    PubMed

    Muller, Eugenio E; Rigamonti, Antonello E; Colonna, Vito De Gennaro; Locatelli, Vittorio; Berti, Ferruccio; Cella, Silvano G

    2002-01-01

    Growth hormone (GH) secretion declines with aging in mammals, including humans. Defective pituitary function does not play a major role in this event. Rather, age-related changes involving the function of specific hypothalamic peptides for GH regulation, GH-releasing hormone (GHRH) and somatostatin (SS), appear to be the fundamental factors. Experimental evidence indicates that GHRH synthesis is impaired with aging in the rat hypothalamus, and that a relative hyperfunction of the SS-ergic system is present. In the elderly, systemic, short-term administration of GHRH enhances GH secretion and increases the formation of the GH-dependent peptide IGF-1. In old dogs, a combination of GHRH and clonidine (CLO), an alpha(2)-adrenoceptor agonist, reportedly acting via GHRH stimulation and SS inhibition, is the most effective stimulus to rejuvenate the apulsatile GH secretion. Discovery of GH secretagogues (GHSs), a series of peptydil and non-peptydil synthetic molecules endowed with a strong GH-releasing activity, the cloning of a GHS receptor (GHS-R), present in the hypothalamus and the pituitary, the isolation of the endogenous ligand of GHS-R, ghrelin, a 28-amino acid peptide whose main source is the stomach, pose the issue for the physiologic role of the GHS/ghrelin system and forces revision of our current understanding of GH regulation in different GH deficiency (GHD) states, including aging. GHSs are very effective for enhancing GH secretion in old subjects, but long-term studies are needed to assess their safety and the real biological impact of GHS replacement therapy in aging. Therapeutic use of GHSs can also be envisaged to restore, via GH-independent mechanisms, functional, and structural age-related alterations, such as anorexia, sexual dysfunction, cardiovascular damage, bone loss. PMID:12392795

  10. 45 CFR 50.6 - Procedures for submission of application to HHS.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Procedures for submission of application to HHS. 50.6 Section 50.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION U.S. EXCHANGE VISITOR PROGRAM-REQUEST FOR WAIVER OF THE TWO-YEAR FOREIGN RESIDENCE REQUIREMENT § 50.6...

  11. 76 FR 10899 - Proposed HHS Recommendation for Fluoride Concentration in Drinking Water for Prevention of Dental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... dental fluorosis, fluid intake among children, and the contribution of fluoride in drinking water to... HUMAN SERVICES Proposed HHS Recommendation for Fluoride Concentration in Drinking Water for Prevention... extending the comment period for a proposed recommendation that community water systems adjust the amount...

  12. 45 CFR 158.607 - Factors HHS uses to determine the amount of penalty.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Factors HHS uses to determine the amount of penalty. 158.607 Section 158.607 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS... violation. This may include any of the following: (1) The frequency of the violation, taking...

  13. Mixed messages. Just as HHS debuts plan to boost accountability, CMS looks to ease inspections.

    PubMed

    Lovern, E

    2001-11-26

    HHS Secretary Tommy Thompson had good news last week for nursing home advocates, then ran into an ambush. He unveiled a long-anticipated proposal for more public accountability in the industry. The problem was, the public had just found out about possible easing of inspection rules. PMID:11765651

  14. 45 CFR 153.630 - Data validation requirements when HHS operates risk adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Data validation requirements when HHS operates risk adjustment. 153.630 Section 153.630 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT...

  15. 7 CFR 1951.853 - Loan purposes for undisbursed RDLF loan funds from HHS.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Loan purposes for undisbursed RDLF loan funds from HHS. 1951.853 Section 1951.853 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...

  16. 7 CFR 1951.853 - Loan purposes for undisbursed RDLF loan funds from HHS.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Loan purposes for undisbursed RDLF loan funds from HHS. 1951.853 Section 1951.853 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...

  17. 76 FR 20568 - HHS Plan for Retrospective Review Under Executive Order 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... mental health treatment and prevention, assurance of safe and effective drugs and other medical products...; ] DEPARTMENT OF HEALTH AND HUMAN SERVICES 2 CFR Chapters III and XXX 5 CFR Chapter XLV 21 CFR Chapter I 25 CFR... HHS Plan for Retrospective Review Under Executive Order 13563 AGENCY: Department of Health and...

  18. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Pursuant to 5 CFR 2635.203(a), each of the twelve components of HHS listed below is designated as an agency... agencies for purposes of applying any provision of 5 CFR part 2635 or this part to employees of the... Disease Control and Prevention; (6) Centers for Medicare and Medicaid Services; (7) Food and...

  19. 45 CFR 158.607 - Factors HHS uses to determine the amount of penalty.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Factors HHS uses to determine the amount of penalty. 158.607 Section 158.607 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS...

  20. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other HHS... include, but are not limited to: 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45 CFR part 75—Informal grant appeals procedures 45 CFR part...

  1. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other HHS... include, but are not limited to: 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45 CFR part 75—Informal grant appeals procedures 45 CFR part...

  2. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other HHS... include, but are not limited to: 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45 CFR part 75—Informal grant appeals procedures 45 CFR part...

  3. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other HHS... include, but are not limited to: 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45 CFR part 75—Informal grant appeals procedures 45 CFR part...

  4. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other HHS... include, but are not limited to: 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45 CFR part 75—Informal grant appeals procedures 45 CFR part...

  5. Mentoring across Generations: Engaging Age 50+ Adults as Mentors. Research in Action. Issue 8

    ERIC Educational Resources Information Center

    Taylor, Andrea

    2007-01-01

    Recent research has demonstrated that older adult volunteers are more likely to be involved in relationship building with young people who are in difficult situations, in periods of transition, and in educational endeavors than volunteers of younger ages. Research also suggests that nurturing, giving to, and serving others contributes to greater…

  6. 42 CFR 483.405 - Relationship to other HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to those pertaining to nondiscrimination on the basis of race, color, or national origin (45 CFR Part 80), nondiscrimination on the basis of handicap (45 CFR Part 84), nondiscrimination on the basis of age (45 CFR Part 91), protection of human subjects of research (45 CFR Part 46), and fraud and...

  7. 42 CFR 483.405 - Relationship to other HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... origin (45 CFR part 80), nondiscrimination on the basis of handicap (45 CFR part 84), nondiscrimination on the basis of age (45 CFR part 91), protection of human subjects of research (45 CFR part 46), and fraud and abuse (42 CFR part 455). Although those regulations are not in themselves...

  8. 42 CFR 483.405 - Relationship to other HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... origin (45 CFR Part 80), nondiscrimination on the basis of handicap (45 CFR Part 84), nondiscrimination on the basis of age (45 CFR Part 91), protection of human subjects of research (45 CFR Part 46), and fraud and abuse (42 CFR Part 455). Although those regulations are not in themselves...

  9. 42 CFR 483.405 - Relationship to other HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... origin (45 CFR Part 80), nondiscrimination on the basis of handicap (45 CFR Part 84), nondiscrimination on the basis of age (45 CFR Part 91), protection of human subjects of research (45 CFR Part 46), and fraud and abuse (42 CFR Part 455). Although those regulations are not in themselves...

  10. 42 CFR 483.405 - Relationship to other HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to those pertaining to nondiscrimination on the basis of race, color, or national origin (45 CFR Part 80), nondiscrimination on the basis of handicap (45 CFR Part 84), nondiscrimination on the basis of age (45 CFR Part 91), protection of human subjects of research (45 CFR Part 46), and fraud and...

  11. Plenty of action left in northern Europe's middle-aged offshore

    SciTech Connect

    Knott, D.J.

    1994-08-15

    Northern Europe's offshore oil industry this year has begun to reveal several symptoms generally associated with middle age. Though in its prime in terms of oil production, North Sea industry has begun a dramatic slimming program. It has started a search for fresh experiences, and it has begun to revisit the big successes of its youth. The paper cites examples demonstrating these trends. The paper then discusses production, outlook for exploration, trends in the United Kingdom, development advances in the natural gas industry, exploration activities, and redevelopment projects.

  12. Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart.

    PubMed

    Abete, P; Testa, G; Galizia, G; Mazzella, F; Della Morte, D; de Santis, D; Calabrese, C; Cacciatore, F; Gargiulo, G; Ferrara, N; Rengo, G; Sica, V; Napoli, C; Rengo, F

    2005-01-01

    Ischemic preconditioning (IP) has been proposed as an endogenous form of protection against ischemia reperfusion injury. IP, however, does not prevent post-ischemic dysfunction in the aging heart but may be partially corrected by exercise training and food restriction. We investigated the role of exercise training combined with food restriction on restoring IP in the aging heart. Effects of IP against ischemia-reperfusion injury in isolated hearts from adult (A, 6 months old), sedentary 'ad libitum' fed (SL), trained ad libitum fed (TL), sedentary food-restricted (SR), trained- and food-restricted senescent rats (TR) (24 months old) were investigated. Norepinephrine release in coronary effluent was determined by high performance liquid cromatography. IP significantly improved final recovery of percent developed pressure in hearts from A (p<0.01) but not in those from SL (p=NS) vs unconditioned controls. Developed pressure recovery was partial in hearts from TL and SR (64.3 and 67.3%, respectively; p<0.05 vs controls) but it was total in those from TR (82.3%, p=NS vs A; p<0.05 vs hearts from TL and SR). Similarly, IP determined a similar increase of norepinephrine release in A (p<0.001) and in TR (p<0.001, p=NS vs adult). IP was abolished by depletion of myocardial norepinephrine stores by reserpine in all groups. Thus, IP reduces post-ischemic dysfunction in A but not in SL. Moreover, IP was preserved partially in TR and SR and totally in TR. Complete IP maybe due to full restoration of norepinephrine release in response to IP stimulus. PMID:15664731

  13. Action Imitation at 1.5 Years Is Better than Pointing Gesture in Predicting Late Development of Language Production at 3 Years of Age

    ERIC Educational Resources Information Center

    Zambrana, Imac M.; Ystrom, Eivind; Schjolberg, Synnve; Pons, Francisco

    2013-01-01

    This study examined whether poor pointing gestures and imitative actions at 18 months of age uniquely predicted late language production at 36 months, beyond the role of poor language at 18 months of age. Data from the Norwegian Mother and Child Cohort Study were utilized. Maternal reports of the children's nonverbal skills and language were…

  14. National Disaster Medical System; medical manpower component establishment--Health Resources and Services Administration, HHS. Notice.

    PubMed

    1988-04-20

    This notice announces the creation of the medical manpower component within the Health Resources and Services Administration (HRSA), Department of Health and Human Services/Public Health Service (HHS/PHS) as a part of the National Disaster Medical System (NDMS). The NDMS is an organized resource that may be activated to serve national needs in the event of disasters or other major emergencies requiring extraordinary medical services. The manpower component will contain volunteer medical response personnel and technical staff that will be made available in situations requiring substantial medical services from outside the area affected by the disaster or emergency. The manpower component of NDMS is being established by HRSA/HHS/PHS in cooperation with the Department of Defense (DoD), Federal Emergency Management Agency (FEMA), and the Veterans Administration (VA). PMID:10287019

  15. A Delphi Study to Detect Deficiencies and Propose Actions in Real Life Treatment of Neovascular Age-Related Macular Degeneration

    PubMed Central

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S.; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment. PMID:25587438

  16. A delphi study to detect deficiencies and propose actions in real life treatment of neovascular age-related macular degeneration.

    PubMed

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Gallego-Pinazo, Roberto; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment. PMID:25587438

  17. NCI at Frederick Team Receives 2014 HHS Green Champions Award | Poster

    Cancer.gov

    A team of NCI and Leidos Biomedical Research employees at NCI at Frederick received the Energy and Fleet Management Award, one of the 2014 Department of Health and Human Services (HHS) Green Champions Awards, for comparing the costs and energy usage of two -80°C freezer technologies. This was the first scientific study to be jointly conducted by Leidos Biomedical Research’s Applied and Developmental Research Directorate (ADRD) and Facilities Maintenance and Engineering Directorate (FME).  

  18. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  19. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  20. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  1. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  2. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  3. Age-dependent actions of dopamine on inhibitory synaptic transmission in superficial layers of mouse prefrontal cortex.

    PubMed

    Paul, Kush; Cox, Charles L

    2013-03-01

    Numerous developmental changes in the nervous system occur during the first several weeks of the rodent lifespan. Therefore, many characteristics of neuronal function described at the cellular level from in vitro slice experiments conducted during this early time period may not generalize to adult ages. We investigated the effect of dopamine (DA) on inhibitory synaptic transmission in superficial layers of the medial prefrontal cortex (PFC) in prepubertal [postnatal age (P; days) 12-20], periadolescent (P30-48), and adult (P70-100) mice. The PFC is associated with higher-level cognitive functions, such as working memory, and is associated with initiation, planning, and execution of actions, as well as motivation and cognition. It is innervated by DA-releasing fibers that arise from the ventral tegmental area. In slices from prepubertal mice, DA produced a biphasic modulation of inhibitory postsynaptic currents (IPSCs) recorded in layer II/III pyramidal neurons. Activation of D2-like receptors leads to an early suppression of the evoked IPSC, which was followed by a longer-lasting facilitation of the IPSC mediated by D1-like DA receptors. In periadolescent mice, the D2 receptor-mediated early suppression was significantly smaller compared with the prepubertal animals and absent in adult animals. Furthermore, we found significant differences in the DA-mediated lasting enhancement of the inhibitory response among the developmental groups. Our findings suggest that behavioral paradigms that elicit dopaminergic release in the PFC differentially modulate inhibition of excitatory pyramidal neuron output in prepuberty compared with periadolescence and adulthood in the superficial layers (II/III) of the cortex. PMID:23221420

  4. 75 FR 14174 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...; Principle of Stem Cell Maturation. Date: June 1, 2010. Time: 12 p.m. to 3 p.m. Agenda: To review and... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: March 17,...

  5. Bleaching Agent Action on Color Stability, Surface Roughness and Microhardness of Composites Submitted to Accelerated Artificial Aging

    PubMed Central

    Rattacaso, Raphael Mendes Bezerra; da Fonseca Roberti Garcia, Lucas; Aguilar, Fabiano Gamero; Consani, Simonides; de Carvalho Panzeri Pires-de-Souza, Fernanda

    2011-01-01

    Objectives: The purpose of this study was to evaluate the bleaching agent action on color stability, surface roughness and microhardness of composites (Charisma, Filtek Supreme and Heliomolar - A2) submitted to accelerated artificial aging (AAA). Methods: A Teflon matrix (12 x 2 mm) was used to fabricate 18 specimens (n=6) which, after polishing (Sof-Lex), were submitted to initial color reading (ΔE), Knoop microhardness (KHN) (50 g/15 s load) and roughness (Ra) (cut-off 0.25 mm) tests. Afterwards, the samples were submitted to AAA for 384 hours and new color, microhardness and roughness readings were performed. After this, the samples were submitted to daily application (4 weeks) of 16% Carbamide Peroxide (NiteWhite ACP) for 8 hours and kept in artificial saliva for 16 hours. New color, microhardness and roughness readings were made at the end of the cycle, and 15 days after bleaching. Results: Comparison of the ΔE means (2-way ANOVA, Bonferroni, P<.05) indicated clinically unacceptable color alteration for all composites after AAA, but without significant difference. Statistically significant increase in the KHN values after AAA was observed, but without significant alterations 15 days after bleaching. For Ra there was no statistically significant difference after AAA and 15 days after bleaching. Conclusions: The alterations promoted by the bleaching agent and AAA are material dependent. PMID:21494380

  6. Aging.

    PubMed

    Park, Dong Choon; Yeo, Seung Geun

    2013-09-01

    Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction. PMID:24653904

  7. Aging

    PubMed Central

    Park, Dong Choon

    2013-01-01

    Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction. PMID:24653904

  8. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

    PubMed

    Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, E H; Bewick, M; Chavannes, N H; de Sousa, J Correia; Cruz, A A; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, C A; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, A K; Barbara, C; Bateman, E D; Beghé, B; Kheder, A Ben; Bennoor, K S; Benson, M; Bergmann, K C; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, A L; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, L P; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Burney, P G; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, M A; Calverley, P M; Camargos, P A M; Canonica, G W; Camuzat, T; Carlsen, K H; Carr, W; Carriazo, A; Casale, T; Cepeda Sarabia, A M; Chatzi, L; Chen, Y Z; Chiron, R; Chkhartishvili, E; Chuchalin, A G; Chung, K F; Ciprandi, G; Cirule, I; Cox, L; Costa, D J; Custovic, A; Dahl, R; Dahlen, S E; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; De Manuel Keenoy, E; Demoly, P; Denburg, J A; Devillier, P; Didier, A; Dinh-Xuan, A T; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Dykewicz, M S; El-Gamal, Y; Emuzyte, R; Fabbri, L M; Fletcher, M; Fiocchi, A; Fink Wagner, A; Fonseca, J; Fokkens, W J; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioğlu, B; Gereda, J E; González Diaz, S; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, M A; Heaney, L G; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, J O' B; Howarth, P; Humbert, M; Hyland, M E; Illario, M; Ivancevich, J C; Jardim, J R; Jares, E J; Jeandel, C; Jenkins, C; Johnston, S L; Jonquet, O; Julge, K; Jung, K S; Just, J; Kaidashev, I; Kaitov, M R; Kalayci, O; Kalyoncu, A F; Keil, T; Keith, P K; Klimek, L; Koffi N'Goran, B; Kolek, V; Koppelman, G H; Kowalski, M L; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Li, J; Lodrup Carlsen, K; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, M J; Manning, P; Mara, S; Marshall, G D; Masjedi, M R; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Menzies-Gow, A; Merk, H; Michel, J P; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, G M Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, T D; O'Hehir, R E; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, H S; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, T A; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, K F; Raciborski, F; Radier Pontal, F; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, G K; Schunemann, H J; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, F E R; Sisul, J C; Skrindo, I; Smit, H A; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, P J; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, A L; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, D Y; Wahn, U; Wickman, M; Williams, D M; Williams, S; Wright, J; Yawn, B P; Yiallouros, P K; Yusuf, O M; Zaidi, A; Zar, H J; Zernotti, M E; Zhang, L; Zhong, N; Zidarn, M; Mercier, J

    2016-01-01

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. PMID:27478588

  9. Emerging Perception of Causality in Action-and-Reaction Sequences from 4 to 6 Months of Age: Is It Domain-Specific?

    ERIC Educational Resources Information Center

    Schlottmann, Anne; Ray, Elizabeth D.; Surian, Luca

    2012-01-01

    Two experiments (N=136) studied how 4- to 6-month-olds perceive a simple schematic event, seen as goal-directed action and reaction from 3 years of age. In our causal reaction event, a red square moved toward a blue square, stopping prior to contact. Blue began to move away before red stopped, so that both briefly moved simultaneously at a…

  10. Action Imitation at 1 ½ Years is Better Than Pointing Gesture in Predicting Late Development of Language Production at 3 Years of Age

    PubMed Central

    Zambrana, Imac M.; Ystrom, Eivind; Schjølberg, Synnve; Pons, Francisco

    2012-01-01

    This study examined whether poor pointing gestures and imitative actions at 18 months of age uniquely predicted late language production at 36 months, beyond the role of poor language at 18 months of age. Data from the Norwegian Mother and Child Cohort Study were utilized. Maternal reports of the children’s nonverbal skills and language were gathered for 42,517 children aged 18 months and for 28,107 of the same children at 36 months. Panel analysis of latent variables revealed that imitative actions, language comprehension, and language production uniquely contributed to predicting late development of language production, while pointing gestures did not. It is suggested that the results can be explained by underlying symbolic representational skills at 18 months. PMID:23033814

  11. Effect of polyvinyl alcohol concentration in spinning dope on diameter, beads and HHS of produced nanofibers.

    PubMed

    Khajavi, Ramin; Damerchely, Rogheih

    2007-01-15

    In this study it was aimed to produce nano fibers of poly vinyl alcohol PVA polymer via electrospinning ES method and to investigate the role of PVA concentration in the spinning dope on diameter, beads and HHS of produced fibers. Spinning dopes with different concentrations of PVA at rang of 5 to 20% (wt/wt on weight of solution) prepared. The requisite voltage for ES (30 kv) was supplied by a DC high voltage power supply and for collecting the fibers a grounded aluminum foil target placed 17 cm below the tip of capillary tube (spinning nozzle). The results showed that spinning dopes with PVA concentration between 8 to 12% (wt/wt) are capable of producing PVA fibers, but those below 8% (wt/wt) concentrations because of low viscosity formed droplets known as electrospray effect. Electrospinning suppressed at spinning dope concentrations above 12% (wt/wt) due to high viscosity of dope. According to the SEM photographs of electrospun PVA fibers it revealed that in higher concentrations produced nanofibers have larger diameter with less beads and HHS in compare with lower concentrations. PMID:19070034

  12. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity to contest findings of research misconduct and administrative actions. (a) Opportunity to contest....

  13. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity to contest findings of research misconduct and administrative actions. (a) Opportunity to contest....

  14. Une question nouvelle pour l'action educative et la formation: Le viellissement des populations (A New Issue for Educational Action and Training: The Aging of Populations).

    ERIC Educational Resources Information Center

    Gani, Leon

    1993-01-01

    In industrialized societies, life expectancy is increasing while the elderly are increasingly marginalized. Aging, especially with respect to social demography, should be an essential educational topic for teachers and those who care for the elderly. Education for the elderly should help them assume the role of transmitting their knowledge and…

  15. Analysis of newspaper coverage of active aging through the lens of the 2002 World Health Organization Active Ageing Report: A Policy Framework and the 2010 Toronto Charter for Physical Activity: A Global Call for Action.

    PubMed

    Abdullah, Boushra; Wolbring, Gregor

    2013-12-01

    As populations continue to grow older, efforts to support the process of aging well are important goals. Various synonyms are used to cover aging well, such as active aging. The World Health Organization published in 2002 the report Active Ageing: A Policy Framework that according to the call for papers, has brought active ageing to the forefront of international public health awareness. The 2010 Toronto Charter for Physical Activity: A Global Call for Action was singled out in the call for papers as a key document promoting physical activity one goal of the 2002 WHO active aging policy framework. Media are to report to the public topics of importance to them. We investigated the newspaper coverage of aging well and synonymous terms such as active aging through the lens of the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity. As sources we used the following newspapers: China Daily, The Star (Malaysia), two UK newspapers (The Guardian, The Times), a database of 300 Canadian newspapers (Canadian Newsstand) and a US newspaper (The New York Times). The study generated data answering the following four research questions: (1) how often are the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity mentioned; (2) how often is the topic of active aging and terms conveying similar content (aging well, healthy aging, natural aging and successful aging) discussed; (3) which of the issues flagged as important in the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity are covered in the newspaper coverage of active aging and synonymous terms; (4) which social groups were mentioned in the newspapers covered. The study found a total absence of mentioning of the two key documents and a low level of coverage of "active aging" and terms conveying similar content. It found further a lack of engagement with the issues raised in the two key documents and a low level of

  16. Analysis of Newspaper Coverage of Active Aging through the Lens of the 2002 World Health Organization Active Ageing Report: A Policy Framework and the 2010 Toronto Charter for Physical Activity: A Global Call for Action

    PubMed Central

    Abdullah, Boushra; Wolbring, Gregor

    2013-01-01

    As populations continue to grow older, efforts to support the process of aging well are important goals. Various synonyms are used to cover aging well, such as active aging. The World Health Organization published in 2002 the report Active Ageing: A Policy Framework that according to the call for papers, has brought active ageing to the forefront of international public health awareness. The 2010 Toronto Charter for Physical Activity: A Global Call for Action was singled out in the call for papers as a key document promoting physical activity one goal of the 2002 WHO active aging policy framework. Media are to report to the public topics of importance to them. We investigated the newspaper coverage of aging well and synonymous terms such as active aging through the lens of the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity. As sources we used the following newspapers: China Daily, The Star (Malaysia), two UK newspapers (The Guardian, The Times), a database of 300 Canadian newspapers (Canadian Newsstand) and a US newspaper (The New York Times). The study generated data answering the following four research questions: (1) how often are the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity mentioned; (2) how often is the topic of active aging and terms conveying similar content (aging well, healthy aging, natural aging and successful aging) discussed; (3) which of the issues flagged as important in the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity are covered in the newspaper coverage of active aging and synonymous terms; (4) which social groups were mentioned in the newspapers covered. The study found a total absence of mentioning of the two key documents and a low level of coverage of “active aging” and terms conveying similar content. It found further a lack of engagement with the issues raised in the two key documents and a low level

  17. 45 CFR 156.1105 - Establishment of standards for HHS-approved enrollee satisfaction survey vendors for use by QHP...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Establishment of standards for HHS-approved enrollee satisfaction survey vendors for use by QHP issuers in Exchanges. 156.1105 Section 156.1105 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE...

  18. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  19. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  20. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  1. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  2. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  3. 45 CFR 1303.21 - Procedures for appeal by current or prospective delegate agencies to the responsible HHS official...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Procedures for appeal by current or prospective... CURRENT OR PROSPECTIVE DELEGATE AGENCIES Appeals by Current or Prospective Delegate Agencies § 1303.21 Procedures for appeal by current or prospective delegate agencies to the responsible HHS official...

  4. 42 CFR 1007.20 - Circumstances in which data mining is permissible and approval by HHS Office of Inspector General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Circumstances in which data mining is permissible... CONTROL UNITS § 1007.20 Circumstances in which data mining is permissible and approval by HHS Office of Inspector General. (a) Notwithstanding § 1007.19(e)(2), a MFCU may engage in data mining as defined in...

  5. 42 CFR 1007.20 - Circumstances in which data mining is permissible and approval by HHS Office of Inspector General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Circumstances in which data mining is permissible... CONTROL UNITS § 1007.20 Circumstances in which data mining is permissible and approval by HHS Office of Inspector General. (a) Notwithstanding § 1007.19(e)(2), a MFCU may engage in data mining as defined in...

  6. The Effects of Age and Cue-Action Reminders on Event-Based Prospective Memory Performance in Preschoolers

    ERIC Educational Resources Information Center

    Kliegel, Matthias; Jager, Theodor

    2007-01-01

    The present study investigated event-based prospective memory in five age groups of preschoolers (i.e., 2-, 3-, 4-, 5-, and 6-year-olds). Applying a laboratory-controlled prospective memory procedure, the data showed that event-based prospective memory performance improves across the preschool years, at least between 3 and 6 years of age. However,…

  7. Verbal Self-Instructions in Task Switching: A Compensatory Tool for Action-Control Deficits in Childhood and Old Age?

    ERIC Educational Resources Information Center

    Kray, Jutta; Eber, Jutta; Karbach, Julia

    2008-01-01

    This study examined the influence of verbal self-instructions on age differences in task switching. Task-switching ability, measured as the difference between performance in single-task blocks and in mixed-task blocks in which participants switch between two tasks (mixing costs), increases during childhood and decreases in old age. To measure the…

  8. Repetition Errors in Habitual Prospective Memory: Elimination of Age Differences via Complex Actions or Appropriate Resource Allocation

    PubMed Central

    McDaniel, Mark A.; Bugg, Julie M.; Ramuschkat, Grit M.; Kliegel, Matthias; Einstein, Gilles O.

    2009-01-01

    A challenge in habitual prospective memory tasks (e.g., taking medication) is remembering whether or not one has already performed the action. Einstein, McDaniel, Smith, and Shaw (1998, Psychological Science, 9, 284) showed that older adults were more likely to incorrectly repeat an action on habitual prospective memory tasks. Extending this research, we (a) biased participants either toward repetition or omission errors, (b) investigated whether performing a more complicated motor action can reduce repetition errors for older adults, and (c) examined participants’ resource allocation to the prospective memory task. Older adults committed more repetition errors than younger adults regardless of biasing instructions when ongoing task demands were challenging (Experiment 1). Performing the more complex motor action, however, reduced repetition errors for older adults. Further, when the ongoing task was less demanding, older adults’ repetition errors declined to levels of younger adults (Experiment 2). Consistent with this finding, the resource allocation profiles suggested that older participants were monitoring their output (prospective memory execution) in each trial block. PMID:19479480

  9. Emerging perception of causality in action-and-reaction sequences from 4 to 6 months of age: is it domain-specific?

    PubMed

    Schlottmann, Anne; Ray, Elizabeth D; Surian, Luca

    2012-06-01

    Two experiments (N=136) studied how 4- to 6-month-olds perceive a simple schematic event, seen as goal-directed action and reaction from 3 years of age. In our causal reaction event, a red square moved toward a blue square, stopping prior to contact. Blue began to move away before red stopped, so that both briefly moved simultaneously at a distance. Primarily, our study sought to determine from what age infants see the causal structure of this reaction event. In addition, we looked at whether this causal percept depends on an animate style of motion and whether it correlates with tasks assessing goal perception and goal-directed action. Infants saw either causal reactions or noncausal delayed control events in which blue started some time after red stopped. These events involved squares that moved either rigidly or nonrigidly in an apparently animate manner. After habituation to one of the four events, infants were tested on reversal of the habituation event. Spatiotemporal features reversed for all events, but causal roles changed only in reversed reactions. The 6-month-olds dishabituated significantly more to reversal of causal reaction events than to noncausal delay events, whereas younger infants reacted similarly to reversal of both. Thus, perceptual causality for reaction events emerges by 6 months of age, a younger age than previously reported but, crucially, the same age at which perceptual causality for launch events has emerged in prior research. On our second question, animate/inanimate motion had no effect at any age, nor did significant correlations emerge with our additional tasks assessing goal perception or goal-directed object retrieval. Available evidence, here and elsewhere, is as compatible with a view that infants initially see A affecting B, without differentiation into physical or psychological causality, as with the standard assumption of distinct physical/psychological causal perception. PMID:22417922

  10. 77 FR 70955 - FDA Actions Related to Nicotine Replacement Therapies and Smoking-Cessation Products; Report to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 15 FDA Actions Related to Nicotine Replacement... Tobacco Dependence; Public Hearing; Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public hearing; request for comments. SUMMARY: The Food and Drug Administration (FDA)...

  11. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Notifying the respondent of findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent...

  12. How the mode of action affects evidence of planning and movement kinematics in aging: End-state comfort in older adults.

    PubMed

    Scharoun, Sara M; Gonzalez, Dave A; Roy, Eric A; Bryden, Pamela J

    2016-05-01

    Motor deficits are commonly observed with age; however, it has been argued that older adults are more adept when acting in natural tasks and do not differ from young adults in these contexts. This study assessed end-state comfort and movement kinematics in a familiar task to examine this further. Left- and right-handed older adults picked up a glass (upright or overturned) as if to pour water in four modes of action (pantomime, pantomime with image/cup as a guide, actual grasping). With increasing age, a longer deceleration phase (in pantomime without a stimulus) and less end-state comfort (in pantomime without a stimulus and image as a guide) was displayed as the amount of contextual information available to guide movement decreased. Changes in movement strategies likely reflect an increased reliance on feedback control and demonstration of a more cautious movement. A secondary aim of this study was to assess hand preference and performance, considering conflicting reports of manual asymmetries with age. Performance differences in the Grooved Pegboard place task indicate left handers may display a shift towards right handedness in some, but not all cases. Summarizing, this study supports age-related differences in planning and control processes in a familiar task, and changes in manual asymmetries with age in left handers. PMID:26617081

  13. What should be one's moral response to the HHS "contraceptive mandate"?

    PubMed

    Jerome Bracken, W

    2013-02-01

    This article asks how one should morally respond to the HHS contraceptive mandate which is now law and part of the Patient Protection and Affordable Care Act. This article first presents the historical background of the Obama Administration altering the government's 'final rule' for providing health services and protecting conscience rights. The mandate compels individuals and religious groups to provide insurance coverage for contraceptive, abortifacient, and sterilization services even though they are contrary to their values, and it narrowly defines what constitutes a religious group so fewer of them can claim exemption. Hence, the question is: Can individuals and religious groups obey the law without acting against their moral values or denying their religious identity? Using Church documents, the article answers that one cannot formally cooperate in evil but under certain conditions one can materially cooperate. The article uses the Summa Theologiae of Aquinas to explain what constitutes formal cooperation and how obeying the law can be material but not formal cooperation. It then examines whether the present conditions warrant material cooperation. It concludes that they do not and that religious groups are called to act as martyrs and give witness to their religious identity and moral values by resisting the law. PMID:24845754

  14. The bare essentials. Release of LOM report leaves HHS to determine what should be covered by health benefits packages.

    PubMed

    Zigmond, Jessica

    2011-10-10

    In the wake of an IOM report on the criteria HHS should use to determine what benefits will be "essential" under reform, various stakeholders are weighing in. The National Association of Public Hospitals and Health Systems would like "enabling" services--such as language, transportation and case-management services--included, because they help make medical care more effective, says Xiaoyi Huang, left, of the NAPH. PMID:22111491

  15. The high cost of the international aging prisoner crisis: well-being as the common denominator for action.

    PubMed

    Maschi, Tina; Viola, Deborah; Sun, Fei

    2013-08-01

    The aging prisoner crisis continues to gain international attention as the high human, social, and economic costs of warehousing older adults with complex physical, mental health, and social care needs in prison continues to rise. According to the United Nations, older adults and the serious and terminally ill are considered special needs populations subject to special international health and social practice and policy considerations. We argue that older adults in prison have unique individual and social developmental needs that result from life course exposure to cumulative risk factors compounded by prison conditions that accelerate their aging. We position these factors in a social context model of human development and well-being and present a review of international human rights guidelines that pertain to promoting health and well-being to those aging in custody. The study concludes with promising practices and recommendations of their potential to reduce the high direct and indirect economic costs associated with mass confinement of older adults, many of whom need specialized long-term care that global correctional systems are inadequately equipped to provide. PMID:23042691

  16. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...

  17. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...

  18. Office of the Assistant Secretary for Preparedness and Response; HHS Public Health Emergency Medical Countermeasures Enterprise implementation plan for chemical, biological, radiological and nuclear threats. Notice.

    PubMed

    2007-04-23

    The United States faces serious public health threats from the deliberate use of weapons of mass destruction (WMD)--chemical, biological, radiological, or nuclear (CBRN)--by hostile States or terrorists, and from naturally emerging infectious diseases that have a potential to cause illness on a scale that could adversely impact national security. Effective strategies to prevent, mitigate, and treat the consequences of CBRN threats is an integral component of our national security strategy. To that end, the United States must be able to rapidly develop, stockpile, and deploy effective medical countermeasures to protect the American people. The HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has taken a holistic, end-to-end approach that considers multiple aspects of the medical countermeasures mission including research, development, acquisition, storage, maintenance, deployment, and guidance for utilization. Phase one of this approach established the HHS PHEMCE Strategy for Chemical, Biological, Radiological, and Nuclear Threats (HHS PHEMCE Strategy). The HHS PHEMCE Strategy, published in the Federal Register on March 20, 2007, described a framework of strategic policy goals and objectives for identifying medical countermeasure requirements and establishing priorities for medical countermeasure evaluation, development and acquisition. These strategic policy goals and objectives were used to establish the Four Pillars upon which this HHS Public Health Emergency Medical Countermeasures Enterprise Implementation Plan (HHS PHEMCE Implementation Plan) is based. The HHS PHEMCE Implementation Plan considers the full spectrum of medical countermeasures-related activities, including research, development, acquisition, storage/maintenance, deployment, and utilization. The HHS PHEMCE Implementation Plan is consistent with the President's Biodefense for the 21st Century and is aligned with the National Strategy for Medical Countermeasures against

  19. Late-Onset Temperature Reduction Can Retard the Aging Process in Aged Fish Via a Combined Action of an Anti-Oxidant System and the Insulin/Insulin-Like Growth Factor 1 Signaling Pathway

    PubMed Central

    Wang, Xia; Chang, Qingyun; Wang, Yu; Su, Feng

    2014-01-01

    Abstract Two different mechanisms are considered to be related to aging. Cumulative molecular damage caused by reactive oxygen species (ROS), the by-products of oxidative phosphorylation, is one of these mechanisms (ROS concept). Deregulated nutrient sensing by the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway is the second mechanism (IIS concept). Temperature reduction (TR) is known to modulate aging and prolong life span in a variety of organisms, but the mechanisms remain poorly defined. Here we first demonstrate that late-onset TR from 26°C to 22°C extends mean life span and maximum life span by approximately 5.2 and 3 weeks, respectively, in the annual fish Nothobranchius guentheri. We then show that TR is able to decrease the accumulation of the histological aging markers senescence-associated β-galactosidase (SA-β-Gal) in the epithelium and lipofuscin (LF) in the liver and to reduce protein oxidation and lipid peroxidation levels in the muscle. We also show that TR can enhance the activities of catalase, glutathione peroxidase, and superoxide dismutase, and stimulate the synthesis of SirT1 and FOXO3A/FOXO1A, both of which are the downstream regulators of the IIS pathway. Taken together, our findings suggest that late-onset TR, a simple non-intrusion intervention, can retard the aging process in aged fish, resulting in their life span extension, via a synergistic action of an anti-oxidant system and the IIS pathway. This also suggests that combined assessment of the ROS and IIS concepts will contribute to providing a more comprehensive view of the anti-aging process. PMID:25298234

  20. Phototoxic Action Spectrum on a Retinal Pigment Epithelium Model of Age-Related Macular Degeneration Exposed to Sunlight Normalized Conditions

    PubMed Central

    Arnault, Emilie; Barrau, Coralie; Nanteau, Céline; Gondouin, Pauline; Bigot, Karine; Viénot, Françoise; Gutman, Emmanuel; Fontaine, Valérie; Villette, Thierry; Cohen-Tannoudji, Denis; Sahel, José-Alain; Picaud, Serge

    2013-01-01

    Among the identified risk factors of age-related macular degeneration, sunlight is known to induce cumulative damage to the retina. A photosensitive derivative of the visual pigment, N-retinylidene-N-retinylethanolamine (A2E), may be involved in this phototoxicity. The high energy visible light between 380 nm and 500 nm (blue light) is incriminated. Our aim was to define the most toxic wavelengths in the blue-green range on an in vitro model of the disease. Primary cultures of porcine retinal pigment epithelium cells were incubated for 6 hours with different A2E concentrations and exposed for 18 hours to 10 nm illumination bands centered from 380 to 520 nm in 10 nm increments. Light irradiances were normalized with respect to the natural sunlight reaching the retina. Six hours after light exposure, cell viability, necrosis and apoptosis were assessed using the Apotox-Glo Triplex™ assay. Retinal pigment epithelium cells incubated with A2E displayed fluorescent bodies within the cytoplasm. Their absorption and emission spectra were similar to those of A2E. Exposure to 10 nm illumination bands induced a loss in cell viability with a dose dependence upon A2E concentrations. Irrespective of A2E concentration, the loss of cell viability was maximal for wavelengths from 415 to 455 nm. Cell viability decrease was correlated to an increase in cell apoptosis indicated by caspase-3/7 activities in the same spectral range. No light-elicited necrosis was measured as compared to control cells maintained in darkness. Our results defined the precise spectrum of light retinal toxicity in physiological irradiance conditions on an in vitro model of age-related macular degeneration. Surprisingly, a narrow bandwidth in blue light generated the greatest phototoxic risk to retinal pigment epithelium cells. This phototoxic spectrum may be advantageously valued in designing selective photoprotection ophthalmic filters, without disrupting essential visual and non-visual functions of the

  1. Age-related decline in multiple unit action potentials of cerebral cortex correlates with the number of lipofuscin-containing neurons.

    PubMed

    Sharma, D; Singh, R

    1996-08-01

    The present study examined whether there is any obvious correlation between the density of lipofuscin-containing neurons and the spontaneous neuronal action potentials (Multiple Unit Activity, MUA) in the parietal cortex of the aging rat brain. The results showed that MUA counts were decreased with age while the number of lipofuscin-containing neurons was increased. The cortex with the highest percentage of lipofuscin-containing neurons had the lowest MUA counts while the cortex with the lowest percentage of lipofuscin-containing neurons had the highest MUA counts. The inverse correlation between MUA and lipofuscin-containing neuron number was also evident when the population of the lipofuscin-containing neurons was pharmacologically altered in vivo by the administration of anti-lipofuscin drug centrophenoxine. The inverse relationship between MUA and the lipofuscin-containing neuron numbers is consistent with: (i) the correlations of MUA with age-related changes in lipid peroxidation and biochemically measured lipofuscin concentration, and (ii) the oxidative stress-induced impairments of neuronal electrophysiology. PMID:8979484

  2. National Vaccine Injury Compensation Program: addition of vaccines against rotavirus to the program. Department of Health and Human Services (HHS), Public Health Service (PHS), Health Resources and Services Administration (HRSA). Final rule.

    PubMed

    1999-07-27

    This final rule amends the existing regulations governing the National Vaccine Injury Compensation Program (VICP) by adding vaccines against rotavirus to the Table of Injuries, which lists the vaccines covered under the VICP. This action is taken under section 2114(e) of the Public Health Service Act (the Act). The VICP provides a system of no-fault compensation for certain individuals who have been injured by specific childhood vaccines. The two prerequisites for adding vaccines against rotavirus to the VICP have been satisfied. An excise tax of 75 cents per dose was enacted on October 21, 1998, and took effect for sales of the vaccines after October 21, 1998. The Centers for Disease Control and Prevention (CDC) has recommended to the Secretary of HHS that this vaccine be routinely administered to children. Thus, vaccines against rotavirus are now included in the VICP. PMID:10558598

  3. C2 and CFB Genes in Age-Related Maculopathy and Joint Action with CFH and LOC387715 Genes

    PubMed Central

    Jakobsdottir, Johanna; Conley, Yvette P.; Weeks, Daniel E.; Ferrell, Robert E.; Gorin, Michael B.

    2008-01-01

    Background Age-related maculopathy (ARM) is a common cause of visual impairment in the elderly populations of industrialized countries and significantly affects the quality of life of those suffering from the disease. Variants within two genes, the complement factor H (CFH) and the poorly characterized LOC387715 (ARMS2), are widely recognized as ARM risk factors. CFH is important in regulation of the alternative complement pathway suggesting this pathway is involved in ARM pathogenesis. Two other complement pathway genes, the closely linked complement component receptor (C2) and complement factor B (CFB), were recently shown to harbor variants associated with ARM. Methods/Principal Findings We investigated two SNPs in C2 and two in CFB in independent case-control and family cohorts of white subjects and found rs547154, an intronic SNP in C2, to be significantly associated with ARM in both our case-control (P-value 0.00007) and family data (P-value 0.00001). Logistic regression analysis suggested that accounting for the effect at this locus significantly (P-value 0.002) improves the fit of a genetic risk model of CFH and LOC387715 effects only. Modeling with the generalized multifactor dimensionality reduction method showed that adding C2 to the two-factor model of CFH and LOC387715 increases the sensitivity (from 63% to 73%). However, the balanced accuracy increases only from 71% to 72%, and the specificity decreases from 80% to 72%. Conclusions/Significance C2/CFB significantly influences AMD susceptibility and although accounting for effects at this locus does not dramatically increase the overall accuracy of the genetic risk model, the improvement over the CFH-LOC387715 model is statistically significant. PMID:18493315

  4. Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS).

    PubMed

    Schachner, Anna; Marek, Ana; Jaskulska, Barbara; Bilic, Ivana; Hess, Michael

    2014-02-19

    Virulent fowl adenovirus (FAdV) serotype 4 strains are the etiological agents of hepatitis-hydropericardium syndrome (HHS), a highly infectious disease in chickens with severe economic impact. In the present study, three different FAdV-4 derived capsid proteins, fiber-1, fiber-2, and hexon loop-1, were expressed in a baculovirus system and tested for their capacity to induce protection in chickens. Purified recombinant proteins were administered to day-old specific pathogen-free (SPF) chickens allocated in three separate groups and challenged with virulent FAdV-4 at 21 days of life. Two additional groups served as controls, a challenge control group with mock-vaccinated but infected birds and a negative control group with PBS injection substituting both vaccination and challenge. The fiber-2 vaccinated group displayed high resistance against the adverse effects of the challenge with only one dead bird out of 28, as compared to the challenge control group where the infection caused 78% mortality. A moderate protective effect resulting in 38% mortality was observed for fiber-1, whereas the hexon loop-1 vaccinated group was not effectively protected as manifested by 73% mortality. While a fiber-2 specific ELISA showed a gradual antibody increase after immunization of birds with the homologous protein, a commercial ELISA did not detect vaccination-induced antibodies in any of the groups but displayed a difference in challenge virus-directed response in protected and non-protected birds. Although immunoblotting confirmed the presence of specific antibodies in all vaccinated groups, the anti-protein sera did not exhibit neutralizing activity. Fecal excretion of challenge virus DNA was detected with a real-time PCR in the majority of tested birds until termination of the study independent of protection, indicating the prevention of clinical symptoms, but not infection, by vaccination. In conclusion, recombinant fiber-2 was identified as a protective immunogen and is

  5. 45 CFR 91.1 - What is the purpose of the Age Discrimination Act of 1975?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false What is the purpose of the Age Discrimination Act of 1975? 91.1 Section 91.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS General § 91.1 What is...

  6. 77 FR 58143 - Interagency Task Force on Antimicrobial Resistance (ITFAR): An Update of A Public Health Action...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... resistance. Action items were organized into four focus areas: Surveillance, Prevention and Control, Research.... Other HHS Task Force members include the Agency for Healthcare Research and Quality (AHRQ), the Centers..., Prevention and Control, Research, and Product Development. Written comments should be submitted following...

  7. 75 FR 34750 - Web-Based Public Meeting To Discuss Issues Related to the Development of an Enforcement Action...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... Access and Advertising Regulation). FDA published the final rule on March 19, 2010 (75 FR 13225) and the... HUMAN SERVICES Food and Drug Administration Web-Based Public Meeting To Discuss Issues Related to the... Administration, HHS. ACTION: Notice of Web-based public meeting; request for data, information, and...

  8. Anti-Allergic Action of Aged Black Garlic Extract in RBL-2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice

    PubMed Central

    Yoo, Jae-Myung; Sok, Dai-Eun

    2014-01-01

    Abstract Garlic (Allium sativum) has been used as a food as well as a component of traditional medicine. Aged black garlic (ABG) is known to have various bioactivities. However, the effect of ABG on allergic response is almost unknown. In the present study, we investigated whether ABG can inhibit immunoglobulin E-mediated allergic response in RBL-2H3 cells as well as in vivo passive cutaneous anaphylaxis (PCA). In in vitro tests, ethyl acetate extract (EBG) of ABG significantly inhibited the release of β-hexosaminidase (IC50, 1.53 mg/mL) and TNF-α (IC50, 0.98 mg/mL). Moreover, BG10, an active fraction of EBG, dramatically suppressed the release of β-hexosaminidase (IC50, 53.60 μg/mL) and TNF-α (IC50, 27.80 μg/mL). In addition, BG10 completely blocked the formation of prostaglandin E2 and leukotriene B4 at ≥25 μg/mL. When the effect of BG10 on FcɛRI receptor cascade was investigated, BG10 significantly inhibited the phosphorylation of Syk, but not Lyn. Furthermore, BG10 dose dependently decreased the phosphorylation of cytosolic phospholipase A2 (cPLA2) and 5-lipoxygenase (5-LO) as well as the expression of cyclooxygenase-2 (COX-2). Consistent with what has been mentioned earlier, BG10 also significantly inhibited the PCA reaction in mice. In conclusion, these results indicate that ABG suppresses the allergic response, and the mechanism for its anti-allergic action may involve suppressions of Syk, cPLA2, 5-LO, and COX-2. The anti-allergic actions of ABG, EBG, or BG10 suggest that they may be useful as functional foods for allergic diseases. PMID:24456359

  9. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.

    PubMed

    Yoo, Jae-Myung; Sok, Dai-Eun; Kim, Mee Ree

    2014-01-01

    Garlic (Allium sativum) has been used as a food as well as a component of traditional medicine. Aged black garlic (ABG) is known to have various bioactivities. However, the effect of ABG on allergic response is almost unknown. In the present study, we investigated whether ABG can inhibit immunoglobulin E-mediated allergic response in RBL-2H3 cells as well as in vivo passive cutaneous anaphylaxis (PCA). In in vitro tests, ethyl acetate extract (EBG) of ABG significantly inhibited the release of β-hexosaminidase (IC₅₀, 1.53 mg/mL) and TNF-α (IC₅₀, 0.98 mg/mL). Moreover, BG10, an active fraction of EBG, dramatically suppressed the release of β-hexosaminidase (IC₅₀, 53.60 μg/mL) and TNF-α (IC₅₀, 27.80 μg/mL). In addition, BG10 completely blocked the formation of prostaglandin E₂ and leukotriene B₄ at ≥25 μg/mL. When the effect of BG10 on FcɛRI receptor cascade was investigated, BG10 significantly inhibited the phosphorylation of Syk, but not Lyn. Furthermore, BG10 dose dependently decreased the phosphorylation of cytosolic phospholipase A₂ (cPLA₂) and 5-lipoxygenase (5-LO) as well as the expression of cyclooxygenase-2 (COX-2). Consistent with what has been mentioned earlier, BG10 also significantly inhibited the PCA reaction in mice. In conclusion, these results indicate that ABG suppresses the allergic response, and the mechanism for its anti-allergic action may involve suppressions of Syk, cPLA₂, 5-LO, and COX-2. The anti-allergic actions of ABG, EBG, or BG10 suggest that they may be useful as functional foods for allergic diseases. PMID:24456359

  10. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  11. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify nonprofit organizations that surplus real property and related personal property is available for educational and public health purposes? 102-75.495 Section 102-75.495...

  12. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify nonprofit organizations that surplus real property and related personal property is available for educational and public health purposes? 102-75.495 Section 102-75.495...

  13. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  14. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  15. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats.

    PubMed

    Vega Rivera, Nelly M; Gallardo Tenorio, Alfredo; Fernández-Guasti, Alonso; Estrada Camarena, Erika

    2016-01-01

    The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE₂) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE₂ (1.25, 2.5 or 5.0 µg/rat, s.c.; -48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE₂ (1.25 µg/rat, s.c., -48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE₂ administration. EE₂ (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE₂ (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE₂ was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE₂ alone or in combination with CIT. PMID:27153072

  16. Reversing Cancer Multidrug Resistance in Xenograft Models via Orchestrating Multiple Actions of Functional Mesoporous Silica Nanoparticles.

    PubMed

    Yang, Debin; Wang, Tingfang; Su, Zhigui; Xue, Lingjing; Mo, Ran; Zhang, Can

    2016-08-31

    A multistimuli responsive drug delivery system (DDS) based on sulfhydryl and amino-cofunctionalized mesoporous silica nanoparticles (SH/NH2-MSNs) has been developed, in which the multifunctional hyaluronic acid (HA) derivatives were grafted onto the SH/NH2-MSNs by disulfide bonds for targeting delivery, controlling drug release and reversing multidrug resistance (MDR). The doxorubicin (Dox) loaded multifunctional HA derivatives modified mesoporous silica nanoparticles (Dox/HHS-MSNs) were enzyme and redox sensitive, which could respond to the intracellular stimuli of hyaluronidase (HAase) and glutathione (GSH) successively and prevent drug leakage before reaching the tumor tissues. The cellular uptake experiments showed that Dox/HHS-MSNs were vulnerable to be endocytosed into the Dox-resistant human breast adenocarcinoma (MCF-7/ADR) cells, efficiently realized the endolysosomal escape and remained in the cytoplasm. Because of orchestrating multiple actions above including active targeting, endolysosomal escape and efficient multilevel drug release, Dox/HHS-MSNs could induce the strongest apoptosis and cytotoxicity of MCF-7/ADR cells. Furthermore, a series of in vivo studies on MCF-7/ADR tumor-bearing xenograft mouse models demonstrated that Dox/HHS-MSNs possessed the enhanced tumor-targeting capacity and the best therapeutic efficacy to reverse cancer MDR. PMID:27420116

  17. Medical devices; laser fluorescence caries detection device. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-04-01

    The Food and Drug Administration (FDA) is classifying the laser fluorescence caries detection device into class II (special controls). The special controls that will apply to this device are set forth below. The agency is taking this action in response to a petition submitted under the Federal Food, Drug, and Cosmetic Act (the act) as amended by the Medical Device Amendments of 1976 (the amendments), the Safe Medical Devices Act of 1990, and the Food and Drug Administration Modernization Act of 1997. The agency is classifying this device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. PMID:11010622

  18. [Definition of "Safety and Hygiene Packages" as a management model for the Hospital Hygiene Service (HHS)].

    PubMed

    Raponi, Matteo; Damiani, Gianfranco; Vincenti, Sara; Wachocka, Malgorzata; Boninti, Federica; Bruno, Stefania; Quaranta, Gianluigi; Moscato, Umberto; Boccia, Stefania; Ficarra, Maria Giovanna; Specchia, Maria Lucia; Posteraro, Brunella; Berloco, Filippo; Celani, Fabrizio; Ricciardi, Walter; Laurenti, Patrizia

    2014-01-01

    The purpose of this research is to identify and formalize the Hospital Hygiene Service activities and products, evaluating them in a cost accounting management view. The ultimate aim, is to evaluate the financial adverse events prevention impact, in an Hospital Hygiene Service management. A three step methodology based on affinity grouping activities, was employed. This methodology led us to identify 4 action areas, with 23 related productive processes, and 86 available safety packages. Owing to this new methodology, we was able to implement a systematic evaluation of the furnished services. PMID:25008222

  19. Medical devices; revocation of cardiac pacemaker registry. Food and Drug Administration, HHS. Final rule.

    PubMed

    1999-11-24

    The Food and Drug Administration (FDA) is issuing a final rule to revoke a regulation requiring a cardiac pacemaker registry. The registry, which was mandated by the Deficit Reduction Act of 1984, requires any physician and any provider of services who requests or receives Medicare payment for an implantation, removal, or replacement of permanent cardiac pacemaker devices and pacemaker leads to submit certain information to the registry. The information is used by FDA to track the performance of permanent cardiac pacemakers and pacemaker leads and by the Health Care Finance Administration (HCFA) to administer its Medicare payment program for these devices. This action is being taken to implement an act to Repeal An Unnecessary Medical Device Reporting Requirement passed by Congress in 1996 to remove the cardiac pacemaker registry to eliminate duplicative and unnecessary reporting. PMID:11010690

  20. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats

    PubMed Central

    Vega Rivera, Nelly M.; Gallardo Tenorio, Alfredo; Fernández-Guasti, Alonso; Estrada Camarena, Erika

    2016-01-01

    The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE2) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE2 (1.25, 2.5 or 5.0 µg/rat, s.c.; −48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE2 (1.25 µg/rat, s.c., −48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE2 administration. EE2 (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE2 (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE2 was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE2 alone or in combination with CIT. PMID:27153072

  1. Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine.

    PubMed

    Sharma, D; Maurya, A K; Singh, R

    1993-01-01

    Changes in lipid peroxidation, lipofuscin concentration, and multiple unit activity (MUA recorded in conscious animals) in the CA3 region were studied in the hippocampus of male Wistar rats aged 4, 8, 16, and 24 months. The lipid peroxidation and lipofuscin concentration were increased with age. The MUA, however, declined with age. Correlational analyses were performed for the four age groups to determine the relationship between the age-associated decline in MUA with the age-related alterations in lipid peroxidation and lipofuscin concentrations. The age-related increase in lipid peroxidation correlated positively with the age-associated increase in lipofuscin concentration. The age-related increases in lipid peroxidation and lipofuscin concentration correlated negatively with the changes in MUA. Since lipid peroxidation may affect neuronal electrophysiology, our data suggested that age-related increase in lipid peroxidation may contribute to an age-associated decline in neuronal electrical activity. Centrophenoxine effects were studied on the three above-mentioned age-associated changes in the hippocampus. The drug had no effect on all three parameters in 4- and 8-month-old rats. In 16- and 24-month-old rats, however, the drug significantly increased the MUA but concomitantly decreased lipofuscin concentration and lipid peroxidation. Correlational analyses of the data on MUA, lipid peroxidation and lipofuscin concentration from the centrophenoxine-treated animals showed that the drug-induced diminution in both lipofuscin and lipid peroxidation was significantly correlated with the drug-induced increase in MUA. The differential effect of the drug in younger (4-8 months) and older (16-24 months) animals indicated that the stimulation of MUA was clearly associated with concomitant decrease in lipid peroxidation and lipofuscin concentration. PMID:8367013

  2. Device costs go under the knife. With four hospitals having won HHS' approval for gain-sharing to shave supply costs, some observers say it's just the beginning.

    PubMed

    Becker, Cinda

    2005-02-21

    HHS' inspector general's office recently had some good news for four hospitals--they can use gain-sharing programs to help cut spending on devices. Joane Goodroe, left, is the consultant who helped the facilities devise proposals with safeguards that could satisfy the feds' worries about violating antikickback laws. "This is about paying physicians to take on the extra job of of reducing costs," Goodroe says. PMID:15765835

  3. It barks, but will it bite? While HHS can review proposed insurance premium increases, it lacks the authority to actually stop them.

    PubMed

    Vesely, Rebecca

    2011-01-01

    HHS has new authority to review proposed insurance premium increases, but no real power to stop them. But at least some states without a rate review process say they welcome any support. "We are borderline at market failure," says Michael McRaith, left, director of the Illinois Department of Insurance. "The expectation is not that rates are going to dramatically or miraculously decline. But that rates will be more stable". PMID:21322334

  4. The Global Energy Crisis: Today and Tomorrow. Developing Proactive Action Student Awareness and Understanding About Finite Fuels and Alternative Energy Sources in a Global Age.

    ERIC Educational Resources Information Center

    Peters, Richard O.

    Background information and a teaching strategy are provided to help students better understand the global energy crisis and learn to take action. An overview of the energy crisis includes a discussion of the unequal distribution of natural resources throughout the world, the finite nature of fossil fuels, and problems associated with the depletion…

  5. Resources for the Aging--An Action Handbook, a Catalogue of Federal Programs, Foundations and Trusts, and Voluntary Agencies that Assist Communities and Individuals to Meet the Needs of the Aging.

    ERIC Educational Resources Information Center

    Office of Economic Opportunity, Washington, DC. Community Action Program.

    Published to stimulate local, state, and national groups to develop programs to assist the aged, this catalog presents information about federal grants-in-aid and basic service programs that serve the old, and about foundations and trusts, and national voluntary agencies supporting programs for the aged or willing to assist local groups organizing…

  6. Choosing Actions

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.

    2013-01-01

    Actions that are chosen have properties that distinguish them from actions that are not. Of the nearly infinite possible actions that can achieve any given task, many of the unchosen actions are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes actions that are chosen from actions that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to action choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769

  7. Intentional Action and Action Slips.

    ERIC Educational Resources Information Center

    Heckhausen, Heinz; Beckmann, Jurgen

    1990-01-01

    An explanation of action slips is offered that examines controlled actions in the context of an intentional behavior theory. Actions are considered guided by mentally represented intentions, subdivided into goal intentions and contingent instrumental intentions. Action slips are categorized according to problem areas in the enactment of goal…

  8. Knowing Minds, Controlling Actions: The Developmental Relations between Theory of Mind and Executive Function from 2 to 4 Years of Age

    ERIC Educational Resources Information Center

    Muller, Ulrich; Liebermann-Finestone, Dana P.; Carpendale, Jeremy I. M.; Hammond, Stuart I.; Bibok, Maximilian B.

    2012-01-01

    This longitudinal study examined the concurrent and predictive relations between executive function (EF) and theory of mind (ToM) in 82 preschoolers who were assessed when they were 2, 3, and 4 years old. The results showed that the concurrent relation between EF and ToM, after controlling for age, verbal ability, and sex, was significant at 3 and…

  9. [Comparative studies of the response of normolipemic and dyslipemic aged subjects to 2 forms of delayed-action nicotinic acid polyesters. Pentaerythrotol tetranicotinate and inositol hexanicotinate. Results of a controlled cross-over trial].

    PubMed

    Ziliotto, G R; Lamberti, G; Wagner, A; Cima, L; Genco, G

    1977-01-01

    A cross-over trial was run to compare the effects of two delayed-action nicotinic acid polyesters (pentaerythritol-tetranticotinate, PETN, and inositol-hexanicotinate, MIEN) in 59 aged normo- and dyslipaemic subjects. PETN tended to normalise the lipid picture in much the same way as nicotin acid, without a drastic effect on circulating lipids and lipoproteins. MIEN, on the other hand, had only a slight effect on total blood lipids, and appeared to be ineffective or negative with respect to the other lipid parameters. PETN proved capable of releasing active concentrations of nicotinic acid in vivo for a period of time that was sufficient to correct hyperlipaemia in age subjects. The side-effects were slight, infrequent and quickly reversible. PMID:345998

  10. Action Learning as Invigoration

    ERIC Educational Resources Information Center

    Chivers, Terence S.

    2011-01-01

    The present account of action learning describes its adoption for pragmatic reasons by the University of the Third Age (U3A). The reason for the existence of this movement is the education of retired people. The account seeks to explain why the action learning method spread from one local U3A to another and across it to other local U3As. The case…

  11. Strategy and plan of action to combat gastro-enteritis and malnutrition in children under two years of age. (Formulated as requested by Resolution No. 7 of the 5th Caribbean Health Ministers Conference, Dominica, February 1973.

    PubMed

    1975-02-01

    The strategy and plan of action to combat gastroenteritis and malnutrtion in children under age 2 in the Caribbean is based on a 4-day Technical Group Meeting held in St. Vincent in January 1974 for this purpose. 7 overall goals -- expressed in terms of morbidity and mortality -- are to be achieved by 1980. Widely distributed safe water supplies and adequate sewage and solid waste disposal are identified as the most urgent needs within the environmental health services. Maternal and Child Health Services must be improved by adopting measures to increase their coverage and outreach into the community. Improved staffing and training, better physical facilities, and upgraded surveillance techniques are among the needed improvements. The importance of the role of family planning is stressed as is immunization. Regarding the treatment of malnutrition and gastroenteritis, the need for a standardized practical management routine is to be met by the publication and distribution of a manual. Coordinated action between the ministries of health and education is a prerequisite to the long overdue development of nutrition education in the schools. The need for consumer education is also emphasized. The strategy and plan of action aims at being sufficiently general to be applicable to all territories within the region, but directions and targets have been made specific wherever this seemed to be warranted and practicable. PMID:1039335

  12. Environmental Action.

    ERIC Educational Resources Information Center

    Lott, Jesse; Allen, Rodney F.

    This booklet, a general guide to citizen eco-action, discusses a plan of action on community environmental problems. It offers factors to be considered in any community eco-action situation, but it is not a rigid set of rules. An overview identifies seven key ideas of environmental issues, including the universal participation of all humans in the…

  13. Action Learning.

    ERIC Educational Resources Information Center

    1996

    These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings from a study…

  14. Action perception predicts action performance

    PubMed Central

    Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.

    2013-01-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113

  15. Medical devices; exemption from premarket notification and reserved devices; class I. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-01-14

    The Food and Drug Administration (FDA) is amending its classification regulations to designate class I devices that are exempt from the premarket notification requirements, subject to certain limitations, and to designate those class I devices that remain subject to premarket notification requirements under the new statutory criteria for premarket notification requirements. The devices FDA is designating as exempt do not include class I devices that have been previously exempted by regulation from the premarket notification requirements. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the 1976 amendments), the Safe Medical Devices Act of 1990 (SMDA), and the FDA Modernization Act of 1997 (FDAMA). FDA is taking this action in order to implement a requirement of FDAMA. Elsewhere in this issue of the Federal Register, FDA is announcing that it is withdrawing proposed rules to revoke existing exemptions from premarket notification for two devices. PMID:11010655

  16. Medical devices; gastroenterology-urology devices; nonimplanted, peripheral electrical continence device. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-04-01

    The Food and Drug Administration (FDA) is classifying the nonimplanted, peripheral electrical continence device into class II (special controls). The special controls that will apply to this device are set forth below. The agency is taking this action in response to a petition submitted under the Federal Food, Drug, and Cosmetic Act (the act) as amended by the Medical Device Amendments of 1976, the Safe Medical Devices Act of 1990, and the Food and Drug Administration Modernization Act of 1997. The agency is classifying this device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. PMID:11010624

  17. Action, human.

    PubMed

    Russo, M T

    2010-01-01

    The term "human action" designates the intentional and deliberate movement that is proper and exclusive to mankind. Human action is a unified structure: knowledge, intention or volition, deliberation, decision or choice of means and execution. The integration between these dimensions appears as a task that demands strength of will to achieve the synthesis of self-possession and self-control that enables full personal realisation. Recently, the debate about the dynamism of human action has been enriched by the contribution of neurosciences. Thanks to techniques of neuroimaging, neurosciences have expanded the field of investigation to the nature of volition, to the role of the brain in decision-making processes and to the notion of freedom and responsibility. PMID:20393686

  18. Correlates of hot day air-conditioning use among middle-aged and older adults with chronic heart and lung diseases: the role of health beliefs and cues to action.

    PubMed

    Richard, Lucie; Kosatsky, Tom; Renouf, Annie

    2011-02-01

    Extreme ambient heat is a serious public health threat, especially for the elderly and persons with pre-existing health conditions. Although much of the excess mortality and morbidity associated with extreme heat is preventable, the adoption of effective preventive strategies is limited. The study reported here tested the predictive power of selected components of the Health Belief Model for air-conditioning (AC) use among 238 non-institutionalized middle-aged and older adults with chronic heart failure and/or chronic obstructive pulmonary disease living in Montréal, Canada. Respondents were recruited through clinics (response rate 71%) and interviews were conducted in their homes or by telephone. Results showed that 73% of participants reported having a home air conditioner. The average number of hours spent per 24-hour period in air-conditioned spaces during heat waves was 14.5 hours (SD = 9.4). Exploratory structural equation modeling showed that specific beliefs about the benefits of and drawbacks to AC as well as internal cues to action were predictive of its level of use, whereas the perceived severity of the effects of heat on health was not. The findings are discussed in light of the need to adequately support effective response to extreme heat in this vulnerable population. PMID:21068164

  19. Action Research

    ERIC Educational Resources Information Center

    Milton-Brkich, Katie Lynn; Shumbera, Kristen; Beran, Becky

    2010-01-01

    Defined as "any systemic inquiry conducted by teachers... for the purpose of gathering information about how their particular schools operate, how they teach, and how their students learn" (Mertler, 2009), "action research" is empowering and professional research done by teachers to inform and improves their own practices. Although there are many…

  20. 77 FR 1693 - Agency Information Collection Activities; Proposed Collection; Comment Request; State Annual Long...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Title VII AGENCY: Administration on Aging, HHS. ] ACTION: Notice SUMMARY: The Administration on Aging... Title VII. DATES: Submit written or electronic comments on the collection of information by March...

  1. Citizen's actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The role played by individual citizens as consumers of energy was examined, with emphasis on studying ways in which their action could result in energy conservation. It was shown that there are ways that energy can be conserved in this way, with citizens acting either individually or in groups. The potential savings are significant, but the actual savings may be quite small. The citizens need to be motivated to save and to believe in a conservation ethic; developing such an ethic is difficult, and perhaps not responsive to the shotgun approach now being attempted. The true course of action may be to synthesize new societal structures that provide the maximum evolution of culture within the limitation of scarce energy resources.

  2. Actionable Nuggets

    PubMed Central

    McColl, Mary Ann; Aiken, Alice; Smith, Karen; McColl, Alexander; Green, Michael; Godwin, Marshall; Birtwhistle, Richard; Norman, Kathleen; Brankston, Gabrielle; Schaub, Michael

    2015-01-01

    Abstract Objective To present the results of a pilot study of an innovative methodology for translating best evidence about spinal cord injury (SCI) for family practice. Design Review of Canadian and international peer-reviewed literature to develop SCI Actionable Nuggets, and a mixed qualitative-quantitative evaluation to determine Nuggets’ effect on physician knowledge of and attitudes toward patients with SCI, as well as practice accessibility. Setting Ontario, Newfoundland, and Australia. Participants Forty-nine primary care physicians. Methods Twenty Actionable Nuggets (pertaining to key health issues associated with long-term SCI) were developed. Nugget postcards were mailed weekly for 20 weeks to participating physicians. Prior knowledge of SCI was self-rated by participants; they also completed an online posttest to assess the information they gained from the Nugget postcards. Participants’ opinions about practice accessibility and accommodations for patients with SCI, as well as the acceptability and usefulness of Nuggets, were assessed in interviews. Main findings With Actionable Nuggets, participants’ knowledge of the health needs of patients with SCI improved, as knowledge increased from a self-rating of fair (58%) to very good (75%) based on posttest quiz results. The mean overall score for accessibility and accommodations in physicians’ practices was 72%. Participants’ awareness of the need for screening and disease prevention among this population also increased. The usefulness and acceptability of SCI Nugget postcards were rated as excellent. Conclusion Actionable Nuggets are a knowledge translation tool designed to provide family physicians with concise, practical information about the most prevalent and pressing primary care needs of patients with SCI. This evidence-based resource has been shown to be an excellent fit with information consumption processes in primary care. They were updated and adapted for distribution by the Canadian

  3. Androgen action.

    PubMed

    Werner, Ralf; Holterhus, Paul-Martin

    2014-01-01

    Androgens are important for male sex development and physiology. Their actions are mediated by the androgen receptor (AR), a ligand-dependent nuclear transcription factor. The activity of the AR is controlled at multiple stages due to ligand binding and induced structural changes assisted by the foldosome, compartmentalization, recruitment of coregulators, posttranslational modifications and chromatin remodeling, leading to subsequent transcription of androgen-responsive target genes. Beside these short-term androgen actions, there is phenomenological and experimental evidence of long-term androgen programming in mammals and in the human during sensitive programming time windows, both pre- and postnatally. At the molecular level, research into androgen insensitivity syndrome has unmasked androgen programming at the transcriptome level, in genital fibroblasts and peripheral blood mononuclear cells, and at the epigenome level. Androgens are crucial for male sex development and physiology during embryogenesis, at puberty and in adult life. Testosterone and its more potent metabolite, dihydrotestosterone, which is converted from testosterone within the target cell by 5α-reductase II, are the main androgens involved in male sex differentiation. Androgen action is mediated by a single AR. The AR belongs to the nuclear receptor 3 group C, composed of the glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), progesterone receptor (NR3C3) and AR (NR3C4), and acts as a ligand-dependent transcription factor. PMID:25247642

  4. Action Learning: Avoiding Conflict or Enabling Action

    ERIC Educational Resources Information Center

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  5. Planning my actions to accommodate yours: joint action development during early childhood.

    PubMed

    Meyer, Marlene; van der Wel, Robrecht P R D; Hunnius, Sabine

    2016-05-01

    The planning and adjusting of one's actions in relation to an action partner is fundamental to smooth joint action. During their first years of life, children gradually become more engaged in joint actions. Here, we investigated whether and at what age children take their partner into account in their action plans to accommodate the other's actions. We focused on children's proactive planning (without prior experience) and flexible adjustment of action plans over time. In a behavioural study, we tested 96 children from four age groups (2½, 3, 3½ and 5 years) in a joint cup-stacking task. Children passed cups to their partner who had only one hand available (alternating over time) to build a tower. Children's response choices were assessed (i.e. passing the cup on the free or occupied side to their partner). The study yielded two major findings. At all ages, children proactively planned their actions in a way that accommodated their partner's actions. However, only by 3½ years did children start to flexibly integrate their partner into their action plans. Even at age 5, children only showed minimal adjustments to their action partner. Candidate processes underlying these developmental changes (e.g. inhibitory control, cognitive flexibility, perspective taking) are discussed. PMID:27069048

  6. Aging Brain, Aging Mind.

    ERIC Educational Resources Information Center

    Selkoe, Dennis J.

    1992-01-01

    Discusses the aging process related to physical changes of the human neural structure involved in learning, memory, and reasoning. Presents evidence that indicates such alterations do not necessarily signal the decline in cognitive function. Vignettes provide images of brain structures involved in learning, memory, and reasoning; hippocampal…

  7. 29 CFR 35.15 - Remedial action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Remedial action. 35.15 Section 35.15 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Remedial action. Even in the absence of a finding of discrimination, a recipient, in administering...

  8. State of Aging and Health in America

    MedlinePlus

    ... Submit What's this? Submit Button The State of Aging and Health in America (SAHA) Recommend on Facebook ... this data for action. Â The State of Aging and Health in America 2013 The 2013 report ...

  9. State and Regional Prevalence of Diagnosed Multiple Chronic Conditions Among Adults Aged ≥18 Years - United States, 2014.

    PubMed

    Ward, Brian W; Black, Lindsey I

    2016-01-01

    The prevalence and care management of multiple (two or more) chronic conditions (MCC) are important public health concerns (1). Approximately 25% of U.S. adults have diagnoses of MCC (2). Care management of MCC presents a challenge to both patients and providers because of the substantial costs associated with treating more than one condition and the traditional care strategies that focus on single conditions as opposed to enhanced care coordination (3,4). Maintaining surveillance, targeting service delivery, and projecting resources are all important to meet this challenge, and these actions can be informed by identifying state and other regional variations in MCC prevalence (5,6). Data from the 2014 National Health Interview Survey (NHIS) were used to estimate prevalence of MCC (defined as two or more of 10 diagnosed chronic conditions) for each U.S. state and region by age and sex. Significant state and regional variation in MCC prevalence was found, with state-level estimates ranging from 19.0% in Colorado to 38.2% in Kentucky. MCC prevalence also varied by region, ranging from 21.4% in the Pacific region to 34.5% in the East South Central region. The prevalence of MCC was higher among women than among men within certain U.S. regions, and was higher in older persons in all regions. Such findings further the research and surveillance objectives stated in the U.S. Department of Health and Human Services (HHS) publication, Multiple Chronic Conditions: A Strategic Framework (1). Furthermore, geographic disparities in MCC prevalence can inform state-level surveillance programs and groups targeting service delivery or allocating resources for MCC prevention activities. PMID:27467707

  10. The Take Action Project

    ERIC Educational Resources Information Center

    Boudreau, Sue

    2010-01-01

    The Take Action Project (TAP) was created to help middle school students take informed and effective action on science-related issues. The seven steps of TAP ask students to (1) choose a science-related problem of interest to them, (2) research their problem, (3) select an action to take on the problem, (4) plan that action, (5) take action, (6)…

  11. Healthy Aging

    MedlinePlus

    ... About Us Contact Us Text size | Print | Healthy Aging This information in Spanish ( en español ) A healthy ... Aging email updates. Enter email address Submit Healthy Aging news Accessibility | Privacy policy | Disclaimers | FOIA | Link to ...

  12. Healthy Aging

    MedlinePlus

    ... A Change Contrast print sign up Share Healthy Aging This category offers tips on how to stay ... with Smell Problems with Taste Skin Care and Aging Sleep and Aging Taking Medicines Talking with Your ...

  13. Less chalk more action

    NASA Astrophysics Data System (ADS)

    Mitriceski Andelkovic, Bojana; Jovic, Sladjana

    2016-04-01

    Less chalk more action Education should not be a mechanical system that operates according to the principles of the orders and implementation. Education should respect the basic laws of the develop and progress. Curiosity is the engine of achievement and children spontaneously and happily learn only if they get interested, if teacher wake up and stimulate their creativity and individuality. We would like to present classes that are realized as thematic teaching with several subjects involved: chemistry, geography, math, art and biology. Classes were organized for students at age from 10 to 13 years, every month during autumn and winter 2015. Better students identified themselves as teachers and presented peer education .Teachers were monitoring the process of teaching and help to develop links between younger and older students, where older students were educators to younger students. Also one student with special needs was involved in this activities and was supported by other students during the workshops The benefit from this project will be represented with evaluation marks. Evaluation table shows that group of ten students(age 10 to13 years) which are selected in October as children with lack of motivation for learning, got better marks, at the end of January , then they had it in the beginning of the semester.

  14. Action Experience and Action Discovery in Medicated Individuals with Parkinson's Disease.

    PubMed

    Bednark, Jeffery G; Reynolds, John N J; Stafford, Tom; Redgrave, Peter; Franz, Elizabeth A

    2016-01-01

    Parkinson's disease (PD) is a neurodegenerative disorder that markedly affects voluntary action. While regular dopamine treatment can help restore motor function, dopamine also influences cognitive portions of the action system. Previous studies have demonstrated that dopamine medication boosts action-effect associations, which are crucial for the discovery of new voluntary actions. In the present study, we investigated whether neural processes involved in the discovery of new actions are altered in PD participants on regular dopamine treatment, compared to healthy age-matched controls. We recorded brain electroencephalography (EEG) activity while PD patients and age-matched controls performed action discovery (AD) and action control tasks. We found that the novelty P3, a component normally present when there is uncertainty about the occurrence of the sensory effect, was enhanced in PD patients. However, AD was maintained in PD patients, and the novelty P3 demonstrated normal learning-related reductions. Crucially, we found that in PD patients the causal association between an action and its resulting sensory outcome did not modulate the amplitude of the feedback correct-related positivity (fCRP), an EEG component sensitive to the association between an action and its resulting effect. Collectively, these preliminary results suggest that the formation of long-term action-outcome representations may be maintained in PD patients on regular dopamine treatment, but the initial experience of action-effect association may be affected. PMID:27610079

  15. Action Experience and Action Discovery in Medicated Individuals with Parkinson’s Disease

    PubMed Central

    Bednark, Jeffery G.; Reynolds, John N. J.; Stafford, Tom; Redgrave, Peter; Franz, Elizabeth A.

    2016-01-01

    Parkinson’s disease (PD) is a neurodegenerative disorder that markedly affects voluntary action. While regular dopamine treatment can help restore motor function, dopamine also influences cognitive portions of the action system. Previous studies have demonstrated that dopamine medication boosts action-effect associations, which are crucial for the discovery of new voluntary actions. In the present study, we investigated whether neural processes involved in the discovery of new actions are altered in PD participants on regular dopamine treatment, compared to healthy age-matched controls. We recorded brain electroencephalography (EEG) activity while PD patients and age-matched controls performed action discovery (AD) and action control tasks. We found that the novelty P3, a component normally present when there is uncertainty about the occurrence of the sensory effect, was enhanced in PD patients. However, AD was maintained in PD patients, and the novelty P3 demonstrated normal learning-related reductions. Crucially, we found that in PD patients the causal association between an action and its resulting sensory outcome did not modulate the amplitude of the feedback correct-related positivity (fCRP), an EEG component sensitive to the association between an action and its resulting effect. Collectively, these preliminary results suggest that the formation of long-term action-outcome representations may be maintained in PD patients on regular dopamine treatment, but the initial experience of action-effect association may be affected. PMID:27610079

  16. Action Learning at Work.

    ERIC Educational Resources Information Center

    Mumford, Alan, Ed.

    This book contains 34 papers examining the theory, process, and outcomes of action learning at work. The following papers are included: "An Introduction to the Text" (Alan Mumford); "The Learning Equation" (Reg Revans); "Action Learning as a Vehicle for Learning" (Alan Mumford); "Placing Action Learning and Action Research in Context" (Cliff…

  17. Action Research Facilitator's Handbook.

    ERIC Educational Resources Information Center

    Caro-Bruce, Cathy

    This handbook is a roadmap for action research facilitators to help groups as they work through the research process. It offers quotations, handouts, strategies, resources, and insights from actual experiences. The sections of the handbook follow the action research cycle, focusing on: "What is Action Research?"; "What is the Action Research…

  18. 44 CFR 7.924 - Affirmative action by recipient.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Affirmative action by... Standards for Determining Age Discrimination § 7.924 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects...

  19. 45 CFR 91.16 - Affirmative action by recipient.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Affirmative action by recipient. 91.16 Section 91... for Determining Age Discrimination § 91.16 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of...

  20. 28 CFR 42.724 - Remedial and affirmative action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Remedial and affirmative action. 42.724... affirmative action. (a) If the Department finds that, in violation of this subpart, a recipient has discriminated on the basis of age, the recipient shall take remedial action that the Department...

  1. 28 CFR 42.724 - Remedial and affirmative action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Remedial and affirmative action. 42.724... affirmative action. (a) If the Department finds that, in violation of this subpart, a recipient has discriminated on the basis of age, the recipient shall take remedial action that the Department...

  2. 34 CFR 110.15 - Affirmative action by recipients.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Affirmative action by recipients. 110.15 Section 110.15... ASSISTANCE Standards for Determining Age Discrimination § 110.15 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome...

  3. 34 CFR 110.15 - Affirmative action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Affirmative action by recipients. 110.15 Section 110.15... ASSISTANCE Standards for Determining Age Discrimination § 110.15 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome...

  4. 34 CFR 110.15 - Affirmative action by recipients.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Affirmative action by recipients. 110.15 Section 110.15... ASSISTANCE Standards for Determining Age Discrimination § 110.15 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome...

  5. 43 CFR 17.315 - Affirmative action by recipients.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Affirmative action by recipients. 17.315... Standards for Determining Age Discrimination § 17.315 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects...

  6. 38 CFR 18.516 - Affirmative action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Affirmative action by... Determining Age Discrimination § 18.516 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of conditions that resulted...

  7. 45 CFR 91.16 - Affirmative action by recipient.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Affirmative action by recipient. 91.16 Section 91... for Determining Age Discrimination § 91.16 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of...

  8. 28 CFR 42.724 - Remedial and affirmative action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Remedial and affirmative action. 42.724... affirmative action. (a) If the Department finds that, in violation of this subpart, a recipient has discriminated on the basis of age, the recipient shall take remedial action that the Department...

  9. 44 CFR 7.924 - Affirmative action by recipient.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Affirmative action by... Standards for Determining Age Discrimination § 7.924 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects...

  10. 43 CFR 17.315 - Affirmative action by recipients.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Affirmative action by recipients. 17.315... Standards for Determining Age Discrimination § 17.315 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects...

  11. 45 CFR 91.16 - Affirmative action by recipient.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Affirmative action by recipient. 91.16 Section 91... for Determining Age Discrimination § 91.16 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of...

  12. 38 CFR 18.516 - Affirmative action by recipients.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Affirmative action by... Determining Age Discrimination § 18.516 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of conditions that resulted...

  13. 38 CFR 18.516 - Affirmative action by recipients.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Affirmative action by... Determining Age Discrimination § 18.516 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of conditions that resulted...

  14. 44 CFR 7.924 - Affirmative action by recipient.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Affirmative action by... Standards for Determining Age Discrimination § 7.924 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects...

  15. 28 CFR 42.724 - Remedial and affirmative action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Remedial and affirmative action. 42.724... affirmative action. (a) If the Department finds that, in violation of this subpart, a recipient has discriminated on the basis of age, the recipient shall take remedial action that the Department...

  16. 34 CFR 110.15 - Affirmative action by recipients.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Affirmative action by recipients. 110.15 Section 110.15... ASSISTANCE Standards for Determining Age Discrimination § 110.15 Affirmative action by recipients. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome...

  17. 45 CFR 91.16 - Affirmative action by recipient.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Affirmative action by recipient. 91.16 Section 91... for Determining Age Discrimination § 91.16 Affirmative action by recipient. Even in the absence of a finding of discrimination, a recipient may take affirmative action to overcome the effects of...

  18. 15 CFR 20.17 - Remedial action by recipients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Conciliation, and Enforcement Procedures § 20.17 Remedial action by recipients. (a) Where DOC finds that a recipient has discriminated on the basis of age, the recipient shall take any remedial action that DOC may... recipient that has discriminated, DOC may require both recipients to take remedial action. (b) Even in...

  19. 15 CFR 20.17 - Remedial action by recipients.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Conciliation, and Enforcement Procedures § 20.17 Remedial action by recipients. (a) Where DOC finds that a recipient has discriminated on the basis of age, the recipient shall take any remedial action that DOC may... recipient that has discriminated, DOC may require both recipients to take remedial action. (b) Even in...

  20. 15 CFR 20.17 - Remedial action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., Conciliation, and Enforcement Procedures § 20.17 Remedial action by recipients. (a) Where DOC finds that a recipient has discriminated on the basis of age, the recipient shall take any remedial action that DOC may... recipient that has discriminated, DOC may require both recipients to take remedial action. (b) Even in...

  1. 15 CFR 20.17 - Remedial action by recipients.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Conciliation, and Enforcement Procedures § 20.17 Remedial action by recipients. (a) Where DOC finds that a recipient has discriminated on the basis of age, the recipient shall take any remedial action that DOC may... recipient that has discriminated, DOC may require both recipients to take remedial action. (b) Even in...

  2. 15 CFR 20.17 - Remedial action by recipients.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Conciliation, and Enforcement Procedures § 20.17 Remedial action by recipients. (a) Where DOC finds that a recipient has discriminated on the basis of age, the recipient shall take any remedial action that DOC may... recipient that has discriminated, DOC may require both recipients to take remedial action. (b) Even in...

  3. Inferences about Action Engage Action Systems

    ERIC Educational Resources Information Center

    Taylor, Lawrence J.; Lev-Ari, Shiri; Zwaan, Rolf A.

    2008-01-01

    Verbal descriptions of actions activate compatible motor responses [Glenberg, A. M., & Kaschak, M. P. (2002). Grounding language in action. "Psychonomic Bulletin & Review, 9", 558-565]. Previous studies have found that the motor processes for manual rotation are engaged in a direction-specific manner when a verb disambiguates the direction of…

  4. Skin Aging

    MedlinePlus

    ... too. Sunlight is a major cause of skin aging. You can protect yourself by staying out of ... person has smoked. Many products claim to revitalize aging skin or reduce wrinkles, but the Food and ...

  5. Age Discrimination--Notice--Filing Notice of Intent to Sue Within 180 Days After the Alleged Violation Is a Jurisdictional Prerequisite to an Action Under the Age Discrimination in Employment Act. Hiscott v. General Elec. Co., 521 F. 2d 632 (6th Cir. 1975)

    ERIC Educational Resources Information Center

    Stiltner, L. Del

    1976-01-01

    The Hiscott decision indicates that the court will require notice to meet specific standards before an individual's right to maintain a civil action under the ADEA becomes operative. It also suggests that strict compliance with the 180-day notice provision will continue to be a condition precedent to suit. (Author/LBH)

  6. Communication & Aging.

    ERIC Educational Resources Information Center

    Arnold, William E.

    This extensive bibliography contains more than 1,800 entries about communication and aging. The citations include journal articles, unpublished papers, speeches, dissertations, research studies, and books that relate aging and the aged to a variety of topics, including the following: physiological deterioration, socialization, political…

  7. Skin Aging

    MedlinePlus

    Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it ... heal, too. Sunlight is a major cause of skin aging. You can protect yourself by staying out ...

  8. Creative Aging.

    ERIC Educational Resources Information Center

    Ager, Charlene Lee; And Others

    1981-01-01

    Explores some divergent attitudes toward aging, negative as well as positive. Presents a neurophysiological framework to support the belief that aging is an active and creative process. Explores physical, psychological, and sociological aspects, and identifies three factors in the creative aging process. (Author/JAC)

  9. Mosaic aging

    PubMed Central

    Walker, Lary C.; Herndon, James G.

    2010-01-01

    Summary Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer to as mosaic aging. Varying genetic, epigenetic and environmental factors (local and extrinsic) contribute to the aging phenotype in a given individual, and these agents influence the type and rate of functional decline, as well as the likelihood of developing age-associated afflictions such as cardiovascular disease, arthritis, cancer, and neurodegenerative disorders. Identifying key factors that drive aging, clarifying their activities in different systems, and in particular understanding how they interact will enhance our comprehension of the aging process, and could yield insights into the permissive role that senescence plays in the emergence of acute and chronic diseases of the elderly. PMID:20110150

  10. Putting Action in Perspective

    ERIC Educational Resources Information Center

    Lozano, Sandra C.; Hard, Bridgette Martin; Tversky, Barbara

    2007-01-01

    Embodied approaches to cognition propose that our own actions influence our understanding of the world. Do other people's actions also have this influence? The present studies show that perceiving another person's actions changes the way people think about objects in a scene. In Study 1, participants viewed a photograph and answered a question…

  11. Conservation Action Handbook.

    ERIC Educational Resources Information Center

    National Rifle Association, Washington, DC.

    Conservation problems are identified, with some suggestions for action. General areas covered are: Wildlife Conservation, Soil Conservation, Clean Water, Air Pollution Action, and Outdoor Recreation Action. Appendices list private organizations or agencies concerned with natural resource use and/or management, congressional committees considering…

  12. Action in Development

    ERIC Educational Resources Information Center

    von Hofsten, Claes

    2007-01-01

    It is argued that cognitive development has to be understood in the functional perspective provided by actions. Actions reflect all aspects of cognitive development including the motives of the child, the problems to be solved, and the constraints and possibilities of the child's body and sensorimotor system. Actions are directed into the future…

  13. Planning as Action Research

    ERIC Educational Resources Information Center

    de Gonzalez, Carmen Beatriz; Hernandez, Teresa; Kusch, Jim; Ryan, Charly

    2004-01-01

    Planning contains so much more than the written plan. Early in 2000, an invitation came from the Collaborative Action Research Network (CARN), to people experienced in action research who might want to help plan and present an action research event for elementary school science teachers in Venezuela, South America, in Autumn 2000. This article…

  14. Participatory Action Research.

    ERIC Educational Resources Information Center

    Walker, Martha Lentz

    1993-01-01

    Describes aspects of participatory action research and considers advantages of using participatory action research in research by disabilities and rehabilitation researchers. Notes that participatory action research can be built into any rehabilitation research design but that it rests upon the recognition of persons with disabilities as integral…

  15. 76 FR 65203 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging ACTION: Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Mechanisms of Osteoporosis II. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  16. Understanding affirmative action.

    PubMed

    Crosby, Faye J; Iyer, Aarti; Sincharoen, Sirinda

    2006-01-01

    Affirmative action is a controversial and often poorly understood policy. It is also a policy that has been widely studied by social scientists. In this review, we outline how affirmative action operates in employment and education settings and consider the major points of controversy. In addition, we detail the contributions of psychologists and other social scientists in helping to demonstrate why affirmative action is needed; how it can have unintended negative consequences; and how affirmative action programs can be most successful. We also review how psychologists have examined variations in people's attitudes toward affirmative action, in part as a means for testing different theories of social behavior. PMID:16318608

  17. [Work capacity and aging].

    PubMed

    Costa, G

    2000-01-01

    Maintaining a good work ability depends on satisfactory health and employment status, which is supported by suitable working conditions and correct life styles. From the biological perspective, ageing means a foreseeable progressive and overall deterioration of the various physiological systems, but not of such a kind and severity to consider most people over 50 as too old or unfit for work, as has been shown by several studies that assessed work ability not only in terms of biological age, but of functional age and actual work output. From the physio-pathological perspective, we can observe either illnesses associated with the passage of time or age-related changes that might precipitate diseases, as well as environmental changes that modulate ageing and developmental changes that accelerate or retard ageing. From the practical point of view, it should taken into account that job demands often do not follow the natural biological and functional changes of the individual, consequently the relative work load can be higher in older workers. On the other hand, ageing also means a professional growth in terms of strategic ability, shrewdness, wisdom and experience. The high interindividual variability of physical, mental and social conditions that is observed with the increase in age makes it necessary to adopt flexible and personally tailored measures, as shown by recent surveys in some European countries aimed at reducing age discrimination and work disability, and at promoting work ability by means of actions directed towards both improvement of work organisation and support of psycho-physical conditions of older workers. PMID:11098594

  18. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: Reasonable factors other than age. 91.14 Section 91.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... otherwise prohibited by § 91.11 which is based on a factor other than age, even though that action may have a disproportionate effect on persons of different ages. An action may be based on a factor...

  19. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: Reasonable factors other than age. 91.14 Section 91.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... otherwise prohibited by § 91.11 which is based on a factor other than age, even though that action may have a disproportionate effect on persons of different ages. An action may be based on a factor...

  20. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: Reasonable factors other than age. 91.14 Section 91.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... otherwise prohibited by § 91.11 which is based on a factor other than age, even though that action may have a disproportionate effect on persons of different ages. An action may be based on a factor...

  1. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: Reasonable factors other than age. 91.14 Section 91.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... otherwise prohibited by § 91.11 which is based on a factor other than age, even though that action may have a disproportionate effect on persons of different ages. An action may be based on a factor...

  2. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-04-04

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  3. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-01-01

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  4. Gastroenterology and urology devices; effective date of requirement for premarket approval of the implanted mechanical/hydraulic urinary continence device. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-09-26

    The Food and Drug Administration (FDA) is issuing a final rule to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for the implanted mechanical/hydraulic urinary continence device, a generic type of medical device intended for the treatment of urinary incontinence. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the amendments), the Safe Medical Devices Act of 1990 (the SMDA), and the Food and Drug Administration Modernization Act of 1997. PMID:11503643

  5. Mechanisms underlying selecting objects for action

    PubMed Central

    Wulff, Melanie; Laverick, Rosanna; Humphreys, Glyn W.; Wing, Alan M.; Rotshtein, Pia

    2015-01-01

    We assessed the factors which affect the selection of objects for action, focusing on the role of action knowledge and its modulation by distracters. Fourteen neuropsychological patients and 10 healthy aged-matched controls selected pairs of objects commonly used together among distracters in two contexts: with real objects and with pictures of the same objects presented sequentially on a computer screen. Across both tasks, semantically related distracters led to slower responses and more errors than unrelated distracters and the object actively used for action was selected prior to the object that would be passively held during the action. We identified a sub-group of patients (N = 6) whose accuracy was 2SDs below the controls performances in the real object task. Interestingly, these impaired patients were more affected by the presence of unrelated distracters during both tasks than intact patients and healthy controls. Note that the impaired patients had lesions to left parietal, right anterior temporal and bilateral pre-motor regions. We conclude that: (1) motor procedures guide object selection for action, (2) semantic knowledge affects action-based selection, (3) impaired action decision making is associated with the inability to ignore distracting information and (4) lesions to either the dorsal or ventral visual stream can lead to deficits in making action decisions. Overall, the data indicate that impairments in everyday tasks can be evaluated using a simulated computer task. The implications for rehabilitation are discussed. PMID:25954177

  6. MRZ-99030 - A novel modulator of Aβ aggregation: I - Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD).

    PubMed

    Parsons, Christopher G; Ruitenberg, Maarten; Freitag, Christine E; Sroka-Saidi, Kamila; Russ, Hermann; Rammes, Gerhard

    2015-05-01

    Therapeutic approaches addressing β-amyloid1-42 (Aβ1-42) aggregation represent a promising neuroprotective strategy for the treatment of Alzheimer's disease, dry age-related macular degeneration (AMD) and glaucoma. MRZ-99030 is a dipeptide containing d-tryptophan and 2-amino-2-methylpropionic acid in clinical development for the topical treatment of glaucoma and AMD. MRZ-99030 is an Aβ aggregation modulator, previously reported to prevent the formation of soluble toxic oligomeric Aβ species. The present study confirmed that MRZ-99030 prevents the formation of oligomeric Aβ species using similar SDS-PAGE experiments. However, additional data from TR-FRET, DLS and AFM experiments revealed that MRZ-99030 does not directly prevent early protein/protein interactions between monomeric Aβ, but rather promotes the formation of large, non-amyloidogenic, amorphous Aβ aggregates and thereby reduces the amount of intermediate toxic soluble oligomeric Aβ species. The affinity of MRZ-99030 to Aβ1-42 determined by SPR was 28.4 nM but the ratio of compound to Aβ is also important: a 10-20 fold excess of MRZ-99030 over Aβ is probably required for effective modulation of protein/protein interactions. For example, in glaucoma, assuming a maximal Aβ concentration of 1-15 nM in the retina, up to 150 nM MRZ-99030 could be required at the protein target. In line with this consideration, MRZ-99030 was able to prevent Aβ-induced toxicity on PC12 cells, retinal ganglion cells and retinal pigment epithelium cells when present at a 10-20 fold stoichiometric excess over Aβ. Moreover, in vivo studies demonstrate the neuroprotective potential of MRZ-99030 after systemic and topical administration in animal models of Alzheimer's disease and glaucoma/AMD respectively. PMID:25634238

  7. Aging and Cardiac Fibrosis

    PubMed Central

    Biernacka, Anna; Frangogiannis, Nikolaos G

    2011-01-01

    The aging heart is characterized by morphological and structural changes that lead to its functional decline and are associated with diminished ability to meet increased demand. Extensive evidence, derived from both clinical and experimental studies suggests that the aging heart undergoes fibrotic remodeling. Age-dependent accumulation of collagen in the heart leads to progressive increase in ventricular stiffness and impaired diastolic function. Increased mechanical load, due to reduced arterial compliance, and direct senescence-associated fibrogenic actions appear to be implicated in the pathogenesis of cardiac fibrosis in the elderly. Evolving evidence suggests that activation of several distinct molecular pathways may contribute to age-related fibrotic cardiac remodeling. Reactive oxygen species, chemokine-mediated recruitment of mononuclear cells and fibroblast progenitors, transforming growth factor (TGF)-β activation, endothelin-1 and angiotensin II signaling mediate interstitial and perivascular fibrosis in the senescent heart. Reduced collagen degradation may be more important than increased de novo synthesis in the pathogenesis of aging-associated fibrosis. In contrast to the baseline activation of fibrogenic pathways in the senescent heart, aging is associated with an impaired reparative response to cardiac injury and defective activation of reparative fibroblasts in response to growth factors. Because these reparative defects result in defective scar formation, senescent hearts are prone to adverse dilative remodeling following myocardial infarction. Understanding the pathogenesis of interstitial fibrosis in the aging heart and dissecting the mechanisms responsible for age-associated healing defects following cardiac injury are critical in order to design new strategies for prevention of adverse remodeling and heart failure in elderly patients. PMID:21837283

  8. Stereoscopically Observing Manipulative Actions

    PubMed Central

    Ferri, S.; Pauwels, K.; Rizzolatti, G.; Orban, G. A.

    2016-01-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors “stimulus type” (action, static control, and dynamic control), “stereopsis” (present, absent) and “viewpoint” (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  9. Stereoscopically Observing Manipulative Actions.

    PubMed

    Ferri, S; Pauwels, K; Rizzolatti, G; Orban, G A

    2016-08-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors "stimulus type" (action, static control, and dynamic control), "stereopsis" (present, absent) and "viewpoint" (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  10. realfriends: A Student Social Action Project

    ERIC Educational Resources Information Center

    Van Zoost, Steven

    2012-01-01

    "realfriends" is a social action project created by Grade 12 English students in Windsor, Nova Scotia. Its purpose was to create a face-to-face social network that would help change the school climate into a more social space. Interest in socializing is nothing new for teenagers, but these students articulated a worry that people their age may be…

  11. Keep Kids Alcohol Free: Strategies for Action.

    ERIC Educational Resources Information Center

    Wendehack, Mary, Ed.; Green, Patricia, Ed.

    This guide was produced by the Leadership To Keep Children Alcohol Free, a coalition of governors' spouses, federal agencies, and public and private organizations which aims to alert the nation of and mobilize action to prevent this critical public health problem. It is the only national effort that focuses on this age group. The guide is an…

  12. Changes in the Body with Aging

    MedlinePlus

    ... action, become more important as people age. Blood Production The amount of active bone marrow, where blood ... bone marrow is less able to increase its production of blood cells in response to the body’s ...

  13. Gastroenterology-urology devices; effective date of requirement for premarket approval of the penile inflatable implant. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-04-12

    The Food and Drug Administration (FDA) is issuing a final rule to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for the penile inflatable implant, a generic type of medical device intended for the treatment of erectile dysfunction. This regulation reflects FDA's exercise of its discretion to require PMA's or PDP's for preamendments devices and is consistent with FDA's stated priorities and Congress' requirement that class III devices are to be regulated by FDA's premarket review. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the amendments), the Safe Medical Devices Act of 1990, and the Food and Drug Administration Modernization Act of 1997. PMID:11010632

  14. Clinical chemistry and clinical toxicology devices; classification of B-type natriuretic peptide test system. Food and Drug Administration, HHS. Final rule.

    PubMed

    2001-02-28

    The Food and Drug Administration (FDA) is classifying the B-type natriuretic peptide (BNP) test system into class II (special controls). The special control that will apply to this device is a guidance document entitled "Class II Special Control Guidance Document for B-Type Natriuretic Peptide Premarket Notifications; Final Guidance for Industry and FDA Reviewers." The agency is taking this action in response to a petition submitted under the Federal Food, Drug, and Cosmetic Act (the act) as amended by the Medical Device Amendments of 1976, the Safe Medical Devices Act of 1990, and the Food and Drug Administration Modernization Act of 1997. The agency is classifying these devices into class II (special controls) in order to provide a reasonable assurance of the safety and effectiveness of the device. PMID:11503864

  15. Immunology and Microbiology Devices; Classification of Anti-Saccharomyces cerevisiae (S. cerevisiae) Antibody (ASCA) Test Systems. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-11-22

    The Food and Drug Administration (FDA) is classifying the Anti-Saccharomyces cerevisiae (S. cerevisiae) antibody (ASCA) test system into class II (special controls). The special control that will apply to this device is a guidance document entitled "Guidance for Industry and FDA Reviewers: Class II Special Control Guidance Document for Anti-Saccharomyces cerevisiae (S. cerevisiae) Antibody (ASCA) Premarket Notifications." Elsewhere in this issue of the Federal Register. FDA is announcing the availability of this guidance document. The agency is taking this action in response to a petition submitted under the Federal Food, Drug, and Cosmetic Act (the act) as amended by the Medical Device Amendments of 1976, the Safe Medical Devices Act of 1990, and the Food and Drug Administration Modernization Act of 1997. The agency is classifying these devices into class II (special controls) in order to provide a reasonable assurance of the safety and effectiveness of the devices. PMID:11503713

  16. Vitamin D and aging.

    PubMed

    Tuohimaa, Pentti

    2009-03-01

    Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan. The phenotype reversed by normalizing vitamin D and/or mineral homeostasis. Thus, hypervitaminosis D due to an increased 1alpha-hydroxylase activity seems to be a cause of the premature aging. In several studies, we have described that a complete or partial lack of vitamin D action (VDR-/- mice and CYP27B1-/-) show almost similar phenotype as FGF23-/- or Klotho-/- mice. VDR mutant mice have growth retardation, osteoporosis, kyphosis, skin thickening and wrinkling, alopecia, ectopic calcification, progressive loss of hearing and balance as well as short lifespan. CYP27B1-/- mice do not show alopecia nor balance deficit, which might be apoVDR-dependent or calcidiol-dependent. The features are typical to premature aging. The phenotype is resistant to a normalization of the mineral homeostasis by a rescue diet containing high calcium and phosphate. Taken together, aging shows a U-shaped dependency on hormonal forms of vitamin D suggesting that there is an optimal concentration of vitamin D in delaying aging phenomena. Our recent study shows that calcidiol is an active hormone. Since serum calcidiol but not calcitriol is fluctuating in physiological situations, calcidiol might determine the biological output of vitamin D action. Due to its high serum concentration and better uptake of calcidiol-DBP by the target cells through the cubilin-megalin system, calcidiol seems to be an important circulating hormone. Therefore, serum calcidiol might be associated with an increased risk of aging-related chronic diseases more directly than calcitriol. Aging and cancer seem to be tightly associated phenomena

  17. Immunological Aging

    EPA Science Inventory

    Immunosenescence is associated with an increased incidence and severity of infections with common pathogens, neoplastic disease and autoimmunity. In general, aging is associated with a decline in function at the cellular level, rather than cell loss, although thymic atrophy and ...

  18. Action Learning in China

    ERIC Educational Resources Information Center

    Marquardt, Michael J.

    2015-01-01

    Action learning was introduced into China less than 20 years ago, but has rapidly become a valuable tool for organizations seeking to solve problems, develop their leaders, and become learning organizations. This article provides an historical overview of action learning in China, its cultural underpinnings, and five case studies. It concludes…

  19. Who Needs Affirmative Action.

    ERIC Educational Resources Information Center

    Ginger, Ann Fagan

    1979-01-01

    Affirmative action and reverse discrimination are discussed. Facts that were omitted from the court record on the Bakke case are examined. The need for encouraging minority students and women to continue to press for school admission and for lawyers to continue to press affirmative action suits is stressed. (MC)

  20. Affirmative Action in Israel.

    ERIC Educational Resources Information Center

    Lerner, Natan

    This paper examines issues of equality, discrimination, affirmative action, and preferential treatment in Israel. An introduction provides a broad outline of topics addressed in the paper: the status of the Jewish sector, with treatment of Jewish immigrants to serve as an example of affirmative action; the policies of the state in relation to the…

  1. Community-Action Learning

    ERIC Educational Resources Information Center

    Bell, Sarah; Mattern, Mark; Telin, Mike

    2007-01-01

    This paper describes and analyzes an undergraduate course entitled Public Interest Research in which students learn research methods by conducting research on behalf of one or more community organizations. Students' work is conceived of as community action learning, a combination of participatory action research and service learning, emphasizing…

  2. Social Action Art Therapy

    ERIC Educational Resources Information Center

    Golub, Deborah

    2005-01-01

    This paper explores intersections among art, action, and community. It describes sociopolitical aspects of the author's art therapy work with survivors of repressive regimes living in Brazil, China, and Denmark and considers ways that unique historical and social processes influenced her conceptualization and practice of social action art therapy.

  3. Training for Nonviolent Action.

    ERIC Educational Resources Information Center

    Olson, Theodore W.; Shivers, Lynne

    The theory and practice of nonviolent action training as it exists to date are reviewed in this pamphlet. A response to a renewal of interest in alternative forms of social action, the pamphlet results specifically from an international seminar of experienced organizers and trainers held at Preston Patrick, Westmorland, England, June 27 - July 2,…

  4. Renormalized action improvements

    SciTech Connect

    Zachos, C.

    1984-01-01

    Finite lattice spacing artifacts are suppressed on the renormalized actions. The renormalized action trajectories of SU(N) lattice gauge theories are considered from the standpoint of the Migdal-Kadanoff approximation. The minor renormalized trajectories which involve representations invariant under the center are discussed and quantified. 17 references.

  5. Action Research and Policy

    ERIC Educational Resources Information Center

    Foreman-Peck, Lorraine; Murray, Jane

    2008-01-01

    This article examines the relationship between action research and policy and the kind of confidence teachers, policy makers and other potential users may have in such research. Many published teacher action research accounts are criticised on the grounds that they do not fully meet the conventional standards for reporting social scientific…

  6. Affirmative Action Report, 1992.

    ERIC Educational Resources Information Center

    Nevada Univ. and Community Coll. System, Reno. Office of the Chancellor.

    All campuses and units of the University and Community College System of Nevada annually submit data to the Chancellor's Office on affirmative action. This report provides tables of affirmative action data for students enrolled during fall 1992 and professional and classified staff employed during 1992. First, student data is provided on gender…

  7. Action spectrum for photocarcinogenesis.

    PubMed

    de Gruijl, F R

    1995-01-01

    The wavelength dependence of the carcinogenicity of ultraviolet (UV) radiation needs to be known in order to assess the carcinogenic risks of various UV sources, most notably the different solar UV spectra at ground level under depleting stratospheric ozone. This wavelength dependence cannot be extracted from human data (e.g., from epidemiology); it can, however, be directly obtained from animal experiments. Precise information on the wavelength dependence, the so-called action spectrum, was not available until recently: erythemal or mutagenic action spectra have been used as substitutes. However, experimental data on skin tumors induced in hairless mice (Skh:HR1) with various polychromatic sources have been building up. Our group has found that none of the substitute action spectra yield a statistically acceptable description of our data, and we have, therefore, derived a new action spectrum, dubbed the SCUP action spectrum (SCUP stands for Skin Cancer Utrecht-Philadelphia, because the action spectrum also fits experimental data from the former Skin and Cancer Hospital in Philadelphia). The SCUP action spectrum has a maximum at 293 nm, and in the UVA region above 340 nm the relative carcinogenicity per J/m2 drops to about 10(-4) of this maximum. The effects of an ozone depletion on solar UV doses weighted with these different action spectra are compared: the erythemal and SCUP weighted dose come out as least sensitive with a 1.3% and 1.4% increase, respectively, for every 1% decrease in ozone. PMID:7597292

  8. Handbook for Ecology Action.

    ERIC Educational Resources Information Center

    Eber, Ronald

    This handbook has been compiled to aid concerned individuals and ecology groups more adequately define their goals, initiate good programs, and take effective action. It examines the ways a group of working individuals can become involved in action programs for ecological change. Part 1 deals with organization, preliminary organizing, structuring,…

  9. ACTION. Annual Report 1974.

    ERIC Educational Resources Information Center

    ACTION, Washington, DC.

    In this report are described projects and activities undertaken by ACTION's volunteer programs in 1974. After an introduction that notes accomplishments of the past year, a review of domestic operations discusses such programs as VISTA, University Year for ACTION, National Student Volunteer Program, Foster Grandparent Program, and others according…

  10. Conscious Vision in Action.

    PubMed

    Briscoe, Robert; Schwenkler, John

    2015-09-01

    It is natural to assume that the fine-grained and highly accurate spatial information present in visual experience is often used to guide our bodily actions. Yet this assumption has been challenged by proponents of the Two Visual Systems Hypothesis (TVSH), according to which visuomotor programming is the responsibility of a "zombie" processing stream whose sources of bottom-up spatial information are entirely non-conscious (Clark, 2007, 2009; Goodale & Milner, 1992, 2004a; Milner & Goodale, 1995/2006, 2008). In many formulations of TVSH, the role of conscious vision in action is limited to "recognizing objects, selecting targets for action, and determining what kinds of action, broadly speaking, to perform" (Clark, 2007, p. 570). Our aim in this study is to show that the available evidence not only fails to support this dichotomous view but actually reveals a significant role for conscious vision in motor programming, especially for actions that require deliberate attention. PMID:25845648

  11. Goal anticipation during action observation is influenced by synonymous action capabilities, a puzzling developmental study.

    PubMed

    Gredebäck, Gustaf; Kochukhova, Olga

    2010-04-01

    Eighteen- and 25-month-old human toddlers' ability to manually solve a puzzle and their ability to anticipate the goal during observation of similar actions were investigated. Results demonstrate that goal anticipation during action observation is dependent on manual ability, both on a group level (only 25-month-olds solved the manual task and anticipated the goal during observation) and individually within the older age group (r (xy) = 0.53). These findings suggests a connection between manual ability and the ability to anticipate the goal of others' actions in toddlers, in accordance with the direct matching hypothesis. PMID:20041233

  12. Following the Action in Action Learning: Towards Ethnomethodological Studies of (Critical) Action Learning

    ERIC Educational Resources Information Center

    Fox, Steve

    2009-01-01

    Action learning is a pedagogical practice that helps participants learn by talking about their workplace action with fellow participants ("comrades in adversity") in their action learning set. This paper raises questions about the action in action learning, such as: how do members of an action learning set learn from and through each other? How do…

  13. Controlling Asthma New Guidelines. New Medications. New Action Plans.

    MedlinePlus

    ... version of this page please turn Javascript on. New Guidelines. New Medications. New Action Plans. People everywhere and in every age ... I am putting the finishing touches on my new studio album that we hope to have out ...

  14. Action spectra again?

    PubMed

    Coohill, T P

    1991-11-01

    Action spectroscopy has a long history and is of central importance to photobiological studies. Action spectra were among the first assays to point to chlorophyll as the molecule most responsible for plant growth and to DNA as the genetic material. It is useful to construct action spectra early in the investigation of new areas of photobiological research in an attempt to determine the wavelength limits of the radiation region causing the studied response. But due to the severe absorption of ultraviolet (UV) radiation by biological samples, UV action spectra were first limited to small cells (bacteria and fungi). Advances in techniques (e.g. single cell culture) and analysis allowed accurate action spectra to be reported even for mammalian cells. But precise analytical action spectra are often difficult to obtain when large, pigmented, or groups of cells are investigated. Here some action spectra are limited in interpretation and merely supply a wavelength vs effect curve. When polychromatic sources are employed, the interpretation of action spectra is even more complex and formidable. But such polychromatic action spectra can be more directly related to ambient responses. Since precise action spectra usually require the completion of a relatively large number of careful experiments using somewhat sophisticated equipment over a range of at least six wavelengths, they are often not pursued. But they remain central to the elucidation of the effect being studied. The worldwide community has agreed that stratospheric ozone is depleting, with the possibility of a consequent rise in the amount of UV-B (290-320 nm) reaching the earth's surface. It is therefore essential that new action spectra be completed for UV-B effects on a large variety of responses of human, animal, and aquatic plant systems. Combining these action spectra with the known amounts of UV-B reaching the biosphere can give rise to solar UV effectiveness spectra that, in turn, can give rise to estimates

  15. Age Rules

    NASA Astrophysics Data System (ADS)

    Taylor, G. J.

    2015-10-01

    The ages of rocks from the lunar highlands vary widely, even for a single rock sample. This makes it difficult to quantitatively test ideas for early lunar differentiation and formation of the crust. Lars Borg and Amy Gaffney (Lawrence Livermore National Laboratory), and Charles Shearer (University of New Mexico) have devised a set of guidelines to apply to geochronological data that leads to a relative ranking of the reliability of the age determined for a sample. Applying their guidelines to existing data for lunar highland rocks shows an upper limit on rock ages between 4340 and 4370 million years. This is essentially the same as the so-called model ages of the formation of KREEP (a chemical component enriched in potassium, rare earth elements, and phosphorous) and of the formation of the deep source regions that melted to produce mare basalts. The numerous ages close to 4370 million years suggests a complicated and protracted cooling of the primordial lunar magma ocean or a widespread vigorous period of magmatic activity in the Moon.

  16. Children Show Heightened Memory for Threatening Social Actions

    ERIC Educational Resources Information Center

    Baltazar, Nicole C.; Shutts, Kristin; Kinzler, Katherine D.

    2012-01-01

    Three experiments investigated whether a negativity bias in social perception extends to preschool-aged children's memory for the details of others' social actions and experiences. After learning about individuals who committed nice or mean social actions, children in Experiment 1 were more accurate at remembering who was mean compared with who…

  17. 41 CFR 101-8.708 - Affirmative action by recipient.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Affirmative action by... affirmative action to overcome the effects resulting in limited participation in the recipient's program or... FEDERAL FINANCIAL ASSISTANCE 8.7-Discrimination Prohibited on the Basis of Age § 101-8.708...

  18. 41 CFR 101-8.708 - Affirmative action by recipient.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Affirmative action by... affirmative action to overcome the effects resulting in limited participation in the recipient's program or... FEDERAL FINANCIAL ASSISTANCE 8.7-Discrimination Prohibited on the Basis of Age § 101-8.708...

  19. 41 CFR 101-8.708 - Affirmative action by recipient.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Affirmative action by... affirmative action to overcome the effects resulting in limited participation in the recipient's program or... FEDERAL FINANCIAL ASSISTANCE 8.7-Discrimination Prohibited on the Basis of Age § 101-8.708...

  20. Remembering Actions: An Analysis of the Sources of Children's Confusions.

    ERIC Educational Resources Information Center

    Foley, Mary Ann; Aman, Christine

    Involving children 7 and 10 years of age, two experiments aimed to clarify the basis of children's confusion about actions they performed and actions they imagined performing. In experiment 1, subjects were assigned to one of three conditions, each involving two different types of tracing exercises. Children traced simple or complex pictures by…

  1. Neural Mechanisms Underlying Action Observation in Adults with Down Syndrome

    ERIC Educational Resources Information Center

    Virji-Babul, Naznin; Moiseev, Alexander; Cheung, Teresa; Weeks, Daniel J.; Cheyne, Douglas; Ribary, Urs

    2010-01-01

    Results of a magnetoencephalography (MEG) brain imaging study conducted to examine the cortical responses during action execution and action observation in 10 healthy adults and 8 age-matched adults with Down syndrome are reported. During execution, the motor responses were strongly lateralized on the ipsilateral rather than the contralateral side…

  2. Plutonium aging

    SciTech Connect

    Olivas, J.D.

    1999-03-01

    The author describes the plutonium aging program at the Los Alamos National Laboratory. The aging of plutonium components in the US nuclear weapons stockpile has become a concern due to several events: the end of the cold war, the cessation of full scale underground nuclear testing as a result of the Comprehensive Test Ban Treaty (CTBT) and the closure of the Rocky Flats Plant--the site where the plutonium components were manufactured. As a result, service lifetimes for nuclear weapons have been lengthened. Dr. Olivas will present a brief primer on the metallurgy of plutonium, and will then describe the technical approach to ascertaining the long-term changes that may be attributable to self-radiation damage. Facilities and experimental techniques which are in use to study aging will be described. Some preliminary results will also be presented.

  3. Understanding aging.

    PubMed

    Strehler, B L

    2000-01-01

    Enormous advances in our understanding of human aging have occurred during the last 50 yr. From the late 19th to the mid-20th centuries only four comprehensive and important sources of information were available: 1. August Weismann's book entitled Essays on Heredity and Kindred Biological Problems (the first of these essays dealt with The Duration of Life; 1). Weissmann states (p. 10) "In the first place in regulating the length of life, the advantage to the species, and not to the individual, is alone of any importance. This must be obvious to any one who has once thoroughly thought out the process of natural selection_". 2. A highly systematized second early source of information on aging was the collection of essays edited by Cowdry and published in 1938. This 900+ page volume contains 34 chapters and was appropriately called Problems of Aging. 3. At about the same time Raymond Pearl published his book on aging (2). Pearl believed that aging was the indirect result of cell specialization and that only the germ line was resistant to aging. Unfortunately Pearl died in the late 1930s and is largely remembered now for having been the founding editor of Quarterly Review of Biology while he was at the Johns Hopkins University, this author's alma mater. 4. Alexis Carrel wrote a monumental scientific and philosophical book, Man, the Unknown (3). Carrel believed that he had demonstrated that vertebrate cells could be kept in culture and live indefinitely, a conclusion challenged by others (more on this later). PMID:22351262

  4. Conscious Control over Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    The extensive involvement of nonconscious processes in human behaviour has led some to suggest that consciousness is much less important for the control of action than we might think. In this article I push against this trend, developing an understanding of conscious control that is sensitive to our best models of overt (that is, bodily) action control. Further, I assess the cogency of various zombie challenges—challenges that seek to demote the importance of conscious control for human agency. I argue that though nonconscious contributions to action control are evidently robust, these challenges are overblown. PMID:26113753

  5. Corrective Action Glossary

    SciTech Connect

    Not Available

    1992-07-01

    The glossary of technical terms was prepared to facilitate the use of the Corrective Action Plan (CAP) issued by OSWER on November 14, 1986. The CAP presents model scopes of work for all phases of a corrective action program, including the RCRA Facility Investigation (RFI), Corrective Measures Study (CMS), Corrective Measures Implementation (CMI), and interim measures. The Corrective Action Glossary includes brief definitions of the technical terms used in the CAP and explains how they are used. In addition, expected ranges (where applicable) are provided. Parameters or terms not discussed in the CAP, but commonly associated with site investigations or remediations are also included.

  6. Genotype × age interaction in human transcriptional ageing

    PubMed Central

    Kent, Jack W.; Göring, Harald H. H.; Charlesworth, Jac C.; Drigalenko, Eugene; Diego, Vincent P.; Curran, Joanne E.; Johnson, Matthew P.; Dyer, Thomas D.; Cole, Shelley A.; Jowett, Jeremy B. M.; Mahaney, Michael C.; Comuzzie, Anthony G.; Almasy, Laura; Moses, Eric K.; Blangero, John; Williams-Blangero, Sarah

    2012-01-01

    Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1,240 individuals in large families and found 4,472 human autosomal transcripts, representing ~4,349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype×age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for UBQLNL expression. Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort. PMID:22871458

  7. Aging Secret

    ERIC Educational Resources Information Center

    Journal of College Science Teaching, 2005

    2005-01-01

    The canny world of advertising has caught on to the free radical theory of aging, marketing a whole array of antioxidants for preventing anything from wrinkles to dry hair to reducing the risk of heart disease--promising to help slow the hands of time. Working with genetically engineered mice--to produce a natural antioxidant enzyme called…

  8. Gay Aging

    ERIC Educational Resources Information Center

    Haber, David

    2009-01-01

    The oldest of the baby boomers (boomers) were age 63 in 2009 and on the verge of retirement. This cohort has had a history of making societal changes throughout its life cycle, and it is unlikely that retirement, as we know it, will remain unscathed. This article highlights two events--the Stonewall Inn riots and two prominent professional…

  9. Gay aging.

    PubMed

    Haber, David

    2009-01-01

    The oldest of the baby boomers (boomers) were age 63 in 2009 and on the verge of retirement. This cohort has had a history of making societal changes throughout its life cycle, and it is unlikely that retirement, as we know it, will remain unscathed. This article highlights two events-the Stonewall Inn riots and two prominent professional associations removing homosexuality from their list of personality disorders-and how they occurred early enough in the gay boomers life cycle to change their attitudes, behaviors, and lifestyles. This article introduces the reader to a broad array of facts, research findings, and issues that inform the topic of gay aging. A summary of the discrimination and legal concerns affecting the gay community are also highlighted. Two influential community programs are identified: Services and Advocacy for Gay Elders (SAGE) and the American Society on Aging's LGBT Aging Issues Network (LAIN). Gerontological educators need to be sensitive to the needs, desires, and resources of the coming cohort of gay boomers, who are more likely to advocate for responsive services, organizations, and policies than the current cohort of gay older adults. PMID:19697188

  10. Immunization Action Coalition

    MedlinePlus

    ... IAC | Contact | A-Z Index | Donate | Shop | SUBSCRIBE Immunization Action Coalition Handouts for Patients & Staff A-Z ... Index Supplies Checklist Administering Vaccines Temperature Logs Adult Vaccination Topics of Interest Documenting Vaccination Translations Parent Handouts ...

  11. Delving into Egocentric Actions

    PubMed Central

    Li, Yin; Ye, Zhefan; Rehg, James M.

    2016-01-01

    We address the challenging problem of recognizing the camera wearer's actions from videos captured by an egocentric camera. Egocentric videos encode a rich set of signals regarding the camera wearer, including head movement, hand pose and gaze information. We propose to utilize these mid-level egocentric cues for egocentric action recognition. We present a novel set of egocentric features and show how they can be combined with motion and object features. The result is a compact representation with superior performance. In addition, we provide the first systematic evaluation of motion, object and egocentric cues in egocentric action recognition. Our benchmark leads to several surprising findings. These findings uncover the best practices for egocentric actions, with a significant performance boost over all previous state-of-the-art methods on three publicly available datasets. PMID:26973427

  12. Caregiver Action Network

    MedlinePlus

    ... main content Caregiver Action Network Toggle navigation Toolbox Forum Volunteers Donate About Us Join National Family Caregivers ... for caring for a loved one Family Caregiver Forum Share and talk with other caregivers Rare Disease ...

  13. Postpartum Depression Action Plan

    MedlinePlus

    MENU Return to Web version Postpartum Depression | Postpartum Depression Action Plan Patient __________________________ Physician/NP/PA __________________ Clinic ____________________________ Phone Number ____________________ Choose one area and add other areas as you begin to ...

  14. Affirmative Action's Contradictory Consequences.

    ERIC Educational Resources Information Center

    Heilman, Madeline E.

    1996-01-01

    Addresses affirmative action's success at creating a more equal workplace. Explores some potential psychological costs of this policy--costs that paradoxically may undermine its objectives--and their implications for achieving the goal of workplace equality. (GR)

  15. The Aging Mover: A Preliminary Report on Constraints to Action.

    ERIC Educational Resources Information Center

    Williams, Kathleen; Bird, Michael

    1992-01-01

    Examined constraints that might result in locomotion declines in older adults. Videotaped movements of healthy, active females between 20 and 80 years. Those over 60 walked at significantly slower speeds, particularly climbing stairs and used smaller range of speeds than younger individuals. Despite slowing, pattern of coordination between limbs…

  16. Teen-Age Pregnancy: The Case for National Action.

    ERIC Educational Resources Information Center

    Wattleton, Faye

    1989-01-01

    Reviews the national impact of adolescent pregnancy with emphasis on the Black community. Criticizes the mass media for exploiting sexual behavior. Proposes a national agenda incorporating comprehensive sex education, family planning services, and educational, economic, and social opportunities. (FMW)

  17. Commitment to action. Population Action International.

    PubMed

    Squires, S

    1994-01-01

    The national chair of Population Action International (formerly the Population Crisis Committee), Robin Chandler Duke, is a crusader for women's reproductive rights. She was in Bangladesh in 1971 during its civil war. Soldiers would rape young Muslim women, and their families would reject them when they became pregnant. The head of the exiled government agreed to let physicians from IPPF perform abortions on these women, which allowed families to take them back. Opposition to the abortions arose, however. This experience in Bangladesh sparked Ms. Duke's interest in population control. Her years as the wife of a US diplomat granted her access to powerful people worldwide. Her predecessor, retired US Army General Bill Draper, called Ms. Duke from his death bed in 1974 to ask her to be national chair of PAI. She served as a delegate in various international meetings, e.g., the 1980 UNESCO meetings in Belgrade. Spain and Luxembourg honored her for her work of campaigning for women's reproductive rights. She believes that rapid population growth is the most significant problem in the world today. It exacerbates poverty, environmental destruction, and political instability. She believes that universal availability of high quality, voluntary family planning services, including safe abortion, is needed to save humanity from the vicious cycle. Since family planning, sex education, and abortion are the most personal and sensitive parts of people's lives, Population Action frames family planning in the context of basic health care. AIDS complicates the issue, because contraception is no longer limited to birth control. Even though the organization realizes that sexual abstinence is the best way to avoid AIDS, it tries to educate female teenagers not to let boys coerce them to have sex. If they do, have sex Population Action advocates condom use. Ms. Duke cites the family planning successes of Indonesia, Zimbabwe, and Thailand. PMID:12319083

  18. Galileons from Lovelock actions

    SciTech Connect

    Van Acoleyen, Karel; Van Doorsselaere, Jos

    2011-04-15

    We demonstrate how, for an arbitrary number of dimensions, the Galileon actions and their covariant generalizations can be obtained through a standard Kaluza-Klein compactification of higher-dimensional Lovelock gravity. In this setup, the dilaton takes on the role of the Galileon. In addition, such compactifications uncover other more general Galilean actions, producing purely second-order equations in the weak-field limit, now both for the Galileon and the metric perturbations.

  19. Cardiac action potential imaging

    NASA Astrophysics Data System (ADS)

    Tian, Qinghai; Lipp, Peter; Kaestner, Lars

    2013-06-01

    Action potentials in cardiac myocytes have durations in the order of magnitude of 100 milliseconds. In biomedical investigations the documentation of the occurrence of action potentials is often not sufficient, but a recording of the shape of an action potential allows a functional estimation of several molecular players. Therefore a temporal resolution of around 500 images per second is compulsory. In the past such measurements have been performed with photometric approaches limiting the measurement to one cell at a time. In contrast, imaging allows reading out several cells at a time with additional spatial information. Recent developments in camera technologies allow the acquisition with the required speed and sensitivity. We performed action potential imaging on isolated adult cardiomyocytes of guinea pigs utilizing the fluorescent membrane potential sensor di-8-ANEPPS and latest electron-multiplication CCD as well as scientific CMOS cameras of several manufacturers. Furthermore, we characterized the signal to noise ratio of action potential signals of varying sets of cameras, dye concentrations and objective lenses. We ensured that di-8-ANEPPS itself did not alter action potentials by avoiding concentrations above 5 μM. Based on these results we can conclude that imaging is a reliable method to read out action potentials. Compared to conventional current-clamp experiments, this optical approach allows a much higher throughput and due to its contact free concept leaving the cell to a much higher degree undisturbed. Action potential imaging based on isolated adult cardiomyocytes can be utilized in pharmacological cardiac safety screens bearing numerous advantages over approaches based on heterologous expression of hERG channels in cell lines.

  20. 45 CFR 1156.7 - Exceptions to the rules against age discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Exceptions to the rules against age discrimination... AGE Standards for Determining Discriminatory Practices § 1156.7 Exceptions to the rules against age... to take an action otherwise prohibited by § 1156.6 if the action reasonably takes into account age...

  1. American Education: Implications from the Information Age.

    ERIC Educational Resources Information Center

    Gardner, William E.

    This paper considers the needs of future educational systems in an age of information. Characteristics of such systems are described and analyzed. An information age educational system would stress the big picture, be experimental, emphasize skills and tools of thought and action and extend throughout life. It would have alternative delivery…

  2. [Addictions and action systems].

    PubMed

    Loonis, E; Apter, M J

    2000-01-01

    Generalizing from some previous analyses of addiction, and introducing the concept of an action system which governs all actions which are focussed on what Brown (1988) calls "hedonic management", we argue that addictions of every kind involve an action system that displays high salience, low variety and low vicariance. Addictions also involve what Apter (1982) calls the "paratelic state". A study was carried out comparing 31 drug addicts with 29 control subjects in terms of action system variables. To measure these variables, we constructed a new instrument, the Activity-System Drawing Test, and also used the Telic Dominance Scale to measure frequency of paratelic states. Dysphoria was measured by means of the BATE (anxiety), IDA-13 (depression), SEI (self-esteem), and TAS-20 (alexithymia) instruments. Strongly significant differences were found between groups for both action system variables and dysphoria, and there were also strong correlations between both groups of variables. This supports the idea that addictions emerge from systemic properties of the action system. PMID:10858918

  3. Aging & Health.

    PubMed

    2016-09-01

    By 2050 an estimated 83.7 million Americans will be ages sixty-five and older, up from 40.3 million in 2010. The shock wave of aging Americans will have profound implications for older people, their families, health care providers, and the economy. Researchers, policy makers, health care leaders, and others are designing responses to the challenges these actuarial shifts will create. For example, delivering health care at home could help keep more older Americans out of costly emergency departments and nursing homes. But such steps require more health care providers, a broader distribution of providers than currently exists, and better use of the resources we have. PMID:27605632

  4. COGNITION, ACTION, AND OBJECT MANIPULATION

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Weigelt, Matthias; Weiss, Daniel J.; van der Wel, Robrecht

    2012-01-01

    Although psychology is the science of mental life and behavior, it has paid little attention to the means by which mental life is translated into behavior. One domain where links between cognition and action have been explored is the manipulation of objects. This article reviews psychological research on this topic, with special emphasis on the tendency to grasp objects differently depending on what one plans to do with the objects. Such differential grasping has been demonstrated in a wide range of object manipulation tasks, including grasping an object in a way that reveals anticipation of the object's future orientation, height, and required placement precision. Differential grasping has also been demonstrated in a wide range of behaviors, including one-hand grasps, two-hand grasps, walking, and transferring objects from place to place as well as from person to person. The populations in whom the tendency has been shown are also diverse, including nonhuman primates as well as human adults, children, and babies. Meanwhile, the tendency is compromised in a variety of clinical populations and in children of a surprisingly advanced age. Verbal working memory is compromised as well if words are memorized while object manipulation tasks are performed; the recency portion of the serial position curve is reduced in this circumstance. In general, the research reviewed here points to rich connections between cognition and action as revealed through the study of object manipulation. Other implications concern affordances, Donders' Law, and naturalistic observation and the teaching of psychology. PMID:22448912

  5. 43 CFR 17.315 - Affirmative action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Affirmative action by recipients. 17.315 Section 17.315 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Age Standards for Determining Age Discrimination...

  6. 43 CFR 17.315 - Affirmative action by recipients.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Affirmative action by recipients. 17.315 Section 17.315 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Age Standards for Determining Age Discrimination...

  7. 43 CFR 17.315 - Affirmative action by recipients.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Affirmative action by recipients. 17.315 Section 17.315 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Age Standards for Determining Age Discrimination §...

  8. Classifying Facial Actions

    PubMed Central

    Donato, Gianluca; Bartlett, Marian Stewart; Hager, Joseph C.; Ekman, Paul; Sejnowski, Terrence J.

    2010-01-01

    The Facial Action Coding System (FACS) [23] is an objective method for quantifying facial movement in terms of component actions. This system is widely used in behavioral investigations of emotion, cognitive processes, and social interaction. The coding is presently performed by highly trained human experts. This paper explores and compares techniques for automatically recognizing facial actions in sequences of images. These techniques include analysis of facial motion through estimation of optical flow; holistic spatial analysis, such as principal component analysis, independent component analysis, local feature analysis, and linear discriminant analysis; and methods based on the outputs of local filters, such as Gabor wavelet representations and local principal components. Performance of these systems is compared to naive and expert human subjects. Best performances were obtained using the Gabor wavelet representation and the independent component representation, both of which achieved 96 percent accuracy for classifying 12 facial actions of the upper and lower face. The results provide converging evidence for the importance of using local filters, high spatial frequencies, and statistical independence for classifying facial actions. PMID:21188284

  9. ES H action plan

    SciTech Connect

    Not Available

    1991-01-01

    This document contains planned actions to correct the deficiencies identified in the Pre-Tiger Team Self-Assessment (PTTSA), January 1991, of Sandia National Laboratories (SNL -- Albuquerque, New Mexico; Tonopah, Nevada; and Kauai, Hawaii). The Self-Assessment was conducted by a Self-Assessment Working Group consisting of 19 department managers, with support from Environment, Safety, and Health (ES H) professionals, from October through December 1990. Findings from other past audits, dating back to 1985, were reviewed and compared with the PTTSA findings to determine if additional findings, key findings, or root causes were warranted. The resulting ES H Action Plan and individual planned actions were prepared by the ES H Action Plan Project Group with assistance from the Program owners/authors during February and March 1991. The plan was reviewed by SNL Management in April 1991. This document serves as a planning instrument for the Laboratories to aid in the scoping and sizing of activities related to ES H compliance for the coming five years. It will be modified as required to ensure a workload/funding balance and to address the findings resulting from the Tiger Team assessment at SNL, Albuquerque. The process of producing this document has served well to prepare SNL, Albuquerque, for the coming task of producing the required post-Tiger Team action plan document. 8 tabs.

  10. Mitigation Action Plan

    SciTech Connect

    Not Available

    1994-02-01

    This Mitigation Action Plan (MAP) focuses on mitigation commitments stated in the Supplemental Environmental Impact Statement (SEIS) and the Record of Decision (ROD) for the Naval Petroleum Reserve No. 1 (NPR-1). Specific commitments and mitigation implementation actions are listed in Appendix A-Mitigation Actions, and form the central focus of this MAP. They will be updated as needed to allow for organizational, regulatory, or policy changes. It is the intent of DOE to comply with all applicable federal, state, and local environmental, safety, and health laws and regulations. Eighty-six specific commitments were identified in the SEIS and associated ROD which pertain to continued operation of NPR-1 with petroleum production at the Maximum Efficient Rate (MER). The mitigation measures proposed are expected to reduce impacts as much as feasible, however, as experience is gained in actual implementation of these measures, some changes may be warranted.

  11. Action languages: Dimensions, effects

    NASA Technical Reports Server (NTRS)

    Hayes, Daniel G.; Streeter, Gordon

    1989-01-01

    Dimensions of action languages are discussed for communication between humans and machines, and the message handling capabilities of object oriented programming systems are examined. Design of action languages is seen to be very contextual. Economical and effective design will depend on features of situations, the tasks intended to be accomplished, and the nature of the devices themselves. Current object oriented systems turn out to have fairly simple and straightforward message handling facilities, which in themselves do little to buffer action or even in some cases to handle competing messages. Even so, it is possible to program a certain amount of discretion about how they react to messages. Such thoughtfulness and perhaps relative autonomy of program modules seems prerequisite to future systems to handle complex interactions in changing situations.

  12. Learning to take actions

    SciTech Connect

    Khardon, R.

    1996-12-31

    We formalize a model for supervised learning of action strategies in dynamic stochastic domains, and show that pac-learning results on Occam algorithms hold in this model as well. We then identify a particularly useful bias for action strategies based on production rule systems. We show that a subset of production rule systems, including rules in predicate calculus style, small hidden state, and unobserved support predicates, is properly learnable. The bias we introduce enables the learning algorithm to invent the recursive support predicates which are used in the action strategy, and to reconstruct the internal state of the strategy. It is also shown that hierarchical strategies are learnable if a helpful teacher is available, but that otherwise the problem is computationally hard.

  13. Improving Learning and Teaching through Action Learning and Action Research.

    ERIC Educational Resources Information Center

    Zuber-Skeriit, Ortrun

    1993-01-01

    A theoretical framework for action learning and action research is presented, as a basis for better understanding college instruction and learning. Action research is viewed as a philosophy, theory of learning, research methodology, and teaching technique. It is argued that action research both increases knowledge and improves teaching.…

  14. The Effect of Action Experience on Sensorimotor EEG Rhythms during Action Observation

    PubMed Central

    Quandt, Lorna C.; Marshall, Peter J.

    2014-01-01

    A recent line of inquiry has examined how an observer’s experience with action changes the neural processing of similar actions when they are subsequently observed. The current study used electroencephalography (EEG) to test the hypothesis that giving participants different types and amounts of experience with specific objects would lead to differential patterns of sensorimotor rhythms during the observation of similar actions on those objects. While EEG was recorded, three groups of participants (n = 20 in each group; mean age = 22.0 years, SD = 2.7) watched video clips of an actor reaching, grasping, and lifting two objects. Participants then received information about differences in weight between the two objects. One group gained this information through extended sensorimotor experience with the objects, a second group received much briefer sensorimotor experience with the objects, and the third group read written information about the objects’ weights. Participants then viewed the action sequences again. For participants who had sensorimotor experience with the objects, the EEG response to viewing the actions was differentially sensitive to the anticipated weight of the objects. We conclude that this sensitivity was based on the participant’s prior sensorimotor experience with the objects. The participants who only received semantic information about the objects showed no such effects. The primary conclusion is that even brief experience with actions affects sensorimotor cortex activity during the subsequent observation of similar actions. PMID:24568874

  15. The effect of action experience on sensorimotor EEG rhythms during action observation.

    PubMed

    Quandt, Lorna C; Marshall, Peter J

    2014-04-01

    A recent line of inquiry has examined how an observer׳s experience with action changes the neural processing of similar actions when they are subsequently observed. The current study used electroencephalography (EEG) to test the hypothesis that giving participants different types and amounts of experience with specific objects would lead to differential patterns of sensorimotor rhythms during the observation of similar actions on those objects. While EEG was recorded, three groups of participants (n=20 in each group; mean age=22.0 years, SD=2.7) watched video clips of an actor reaching, grasping, and lifting two objects. Participants then received information about differences in weight between the two objects. One group gained this information through extended sensorimotor experience with the objects, a second group received much briefer sensorimotor experience with the objects, and the third group read written information about the objects׳ weights. Participants then viewed the action sequences again. For participants who had sensorimotor experience with the objects, the EEG response to viewing the actions was differentially sensitive to the anticipated weight of the objects. We conclude that this sensitivity was based on the participant׳s prior sensorimotor experience with the objects. The participants who only received semantic information about the objects showed no such effects. The primary conclusion is that even brief experience with actions affects sensorimotor cortex activity during the subsequent observation of similar actions. PMID:24568874

  16. Jump into Action

    ERIC Educational Resources Information Center

    Ball, Stephen; Cohen, Ann; Meyer, Margaret

    2012-01-01

    Jump Into Action (JIA) is a school-based team-taught program to help fifth-grade students make healthy food choices and be more active. The JIA team (physical education teacher, classroom teacher, school nurse, and parent) work together to provide a supportive environment as students set goals to improve food choices and increase activity.…

  17. Conclusions and Federal actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Findings regarding fluorocarbon production, the roles of ozone and fluorocarbons in atmospheric chemistry, the depletion of stratospheric ozone by fluorocarbons, and various effects of this depletion are outlined. Research into these areas is described and recommendations are given for governmental action to reduce the release of fluorocarbons to the environment.

  18. The Constitution in Action

    ERIC Educational Resources Information Center

    Potter, Lee Ann

    2007-01-01

    In this article, the author describes the experiences middle school students on a field trip to the new Constitution in Action Learning Lab in the Boeing Learning Center at the National Archives can expect. There, middle school students take on the roles of archivists and researchers collecting and analyzing primary sources from the holdings of…

  19. Cognitive framing in action.

    PubMed

    Huhn, John M; Potts, Cory Adam; Rosenbaum, David A

    2016-06-01

    Cognitive framing effects have been widely reported in higher-level decision-making and have been ascribed to rules of thumb for quick thinking. No such demonstrations have been reported for physical action, as far as we know, but they would be expected if cognition for physical action is fundamentally similar to cognition for higher-level decision-making. To test for such effects, we asked participants to reach for a horizontally-oriented pipe to move it from one height to another while turning the pipe 180° to bring one end (the "business end") to a target on the left or right. From a physical perspective, participants could have always rotated the pipe in the same angular direction no matter which end was the business end; a given participant could have always turned the pipe clockwise or counter-clockwise. Instead, our participants turned the business end counter-clockwise for left targets and clockwise for right targets. Thus, the way the identical physical task was framed altered the way it was performed. This finding is consistent with the hypothesis that cognition for physical action is fundamentally similar to cognition for higher-level decision-making. A tantalizing possibility is that higher-level decision heuristics have roots in the control of physical action, a hypothesis that accords with embodied views of cognition. PMID:26970853

  20. Nutrition Action Pack.

    ERIC Educational Resources Information Center

    Sockut, Joanne; Stumpe, Stephanie

    One of five McDonald's Action Packs, these instructional materials integrate elementary school-level nutrition education into other disciplines--biology, sociology, physiology, mathematics, and art. Contents include four units consisting of twelve activities. Unit 1, Why You Need Food, is a self-examination of what is needed for growth, health,…

  1. SYRACUSE ACTION FOR YOUTH.

    ERIC Educational Resources Information Center

    ADDINGTON, HAROLD E.; AND OTHERS

    A PROPOSAL WAS MADE TO PREVENT AND CONTROL JUVENILE DELINQUENCY BY OPENING OPPORTUNITIES AND DEVELOPING COMPETENCE AMONG DISADVANTAGED YOUTH. THE TOTAL COMMUNITY WAS MOBILIZED TO DEVELOP A PROGRAM TO ATTACK THE PROBLEM AT ALL LEVELS THEY WORKED FOR 18 MONTHS TO PLAN A SERIES OF CREATIVE ACTION PROGRAMS IN EDUCATION, EMPLOYMENT, AND COMMUNITY…

  2. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Triton Coll., River Grove, IL.

    In order to develop an affirmative action plan at Triton College, the college President appointed a committee made up of nine representatives from the various college constituencies, the majority of which were women and minorities, to determine the objectives to be achieved and how to implement them, and to establish appropriate review procedures.…

  3. Justifying Action Research

    ERIC Educational Resources Information Center

    Helskog, Guro Hansen

    2014-01-01

    In this paper I use a general philosophy of science perspective in looking at the problem of justifying action research. First I try to clarify the concept of justification, by contrasting it with the concept of validity, which seems to be used almost as a synonym in some parts of the literature. I discuss the need for taking a stand in relation…

  4. Hope for Environmental Action

    ERIC Educational Resources Information Center

    Fleischer, Barbara J.; DeMoor, Emily

    2015-01-01

    Environmental consciousness-raising programs tend to emphasize the magnitude of imminent ecological disasters, if humans continue on their current trajectory. While these environmental literacy programs also call for action to avoid cataclysmic ecological changes, psychological research on "learned helplessness" suggests that information…

  5. Community Action Curriculum Compendium.

    ERIC Educational Resources Information Center

    Duncan, Karen

    This compendium contains descriptions of 59 community action projects that receive academic credit from 48 colleges and universities. Brief descriptions are given of the diverse institutions offering such field work for credit, including information on enrollment and type (i.e., public, private, etc.). Although the characteristics of the programs…

  6. School Reform in Action.

    ERIC Educational Resources Information Center

    Miller, A. Christine

    This study describes and analyzes the impact on student learning and the learning environment of 55 schools in Broward, Palm Beach, and Miami-Dade school districts as they implemented the schoolwide action-research framework for school improvement. Interviews, observations, document review during site visits, school framework reports, surveys,…

  7. Action Learning Issues.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on adult learning issues and human resource development (HRD). "Creating a Systemic Framework for the Transfer of Learning from an Action Learning Experience" (Suzanne D. Butterfield, Kitty Gold, Verna J. Willis) discusses a study of the organizational elements that affect learning and transfer…

  8. Early Childhood Action Tips.

    ERIC Educational Resources Information Center

    O'Donnell, Nina Sazer

    In response to requests for information from people and organizations all over the United States on how to contribute to the healthy development of young children, the Families and Work Institute has gathered concrete suggestions from leaders in diverse fields into this booklet of action tips. This effort was undertaken to support the "I Am Your…

  9. Quick action clamp

    NASA Technical Reports Server (NTRS)

    Calco, Frank S. (Inventor)

    1991-01-01

    A quick release toggle clamp that utilizes a spring that requires a deliberate positive action for disengagement is presented. The clamp has a sliding bolt that provides a latching mechanism. The bolt is moved by a handle that tends to remain in an engaged position while under tension.

  10. Court Action for Migrants.

    ERIC Educational Resources Information Center

    Ewald, Thomas R.

    Aiding attorneys who represent migrant farmworkers and their families when affirmative civil action is required, this book helps to raise the level of migrants' legal protection to a minimum standard of adequacy. The text is based on the Federal Rules of Civil Procedure, a national set of rules. The book is divided into 3 sections: the…

  11. From Awareness to Action

    ERIC Educational Resources Information Center

    Micklos, John, Jr.

    2012-01-01

    What inspires young people to become activists? Events such as wars or regime changes obviously raise high emotions. But some choose to get involved because they saw a need and felt compelled to take action. Young Americans have a long track record as activists. Among other things, they played a key role in the civil rights movement of the 1950s…

  12. ACTION. Annual Report 1978.

    ERIC Educational Resources Information Center

    ACTION, Washington, DC.

    In this report are described projects and activities undertaken by ACTION's volunteer programs in 1978. The introduction notes a continued growth in programs and comments on new developments. Older American Volunteer Programs are discussed in the next section, specifically the Retired Senior Volunteer Program, Foster Grandparent Program, and…

  13. The Shape of Action

    ERIC Educational Resources Information Center

    Hard, Bridgette Martin; Recchia, Gabriel; Tversky, Barbara

    2011-01-01

    How do people understand the everyday, yet intricate, behaviors that unfold around them? In the present research, we explored this by presenting viewers with self-paced slideshows of everyday activities and recording looking times, subjective segmentation (breakpoints) into action units, and slide-to-slide physical change. A detailed comparison of…

  14. Affirmative Action for Men?

    ERIC Educational Resources Information Center

    Malveaux, Julianne

    2005-01-01

    If colleges are willing to consider "social engineering" and affirmative action to ensure the inclusion of White men, are they willing to do so for African Americans and other people of color? Will the Center for Individual Rights ride to the rescue of the White women who may be unfairly nudged out of positions for which they are "qualified" in…

  15. Instructional Rounds in Action

    ERIC Educational Resources Information Center

    Roberts, John E.

    2012-01-01

    "Instructional Rounds in Action" is an invaluable guide for those involved in implementing instructional rounds as the foundation and framework for systemic improvement in schools. Over the past few years, districts across the United States, Canada, and Australia have begun implementing "instructional rounds," a set of ideas and practices for…

  16. Action for Children's Television.

    ERIC Educational Resources Information Center

    Ranly, Donald P.

    The origins, development, and effectiveness of Action for Children's Television (ACT) are examined in this pamphlet. The strategies used by ACT to obtain change at the congressional level and within television stations and networks include the following: a "tuneout" day when people are urged to turn off their television sets, a boycott of certain…

  17. From Intuition to Action

    ERIC Educational Resources Information Center

    Principal, 2012

    2012-01-01

    The vast majority of principals intuitively believe that the arts belong in schools and in every child's life. Now is the time to take action on your intuition--and become an instructional leader for the arts, just as you are for every core subject. Arts-engaged principals share strategies for becoming instructional leaders for the arts.

  18. Action Research in Practice

    ERIC Educational Resources Information Center

    Piggot-Irvine, Eileen

    2009-01-01

    Action research places a powerful tool for school improvement in the hands of teachers. By highlighting the outcomes that are possible and presenting clear steps in the research process, this book is one to encourage anyone who is seeking to implement evidence-based school improvement. Eileen Piggot-Irvine uses her Problem Resolving Action…

  19. Conjugate flow action functionals

    SciTech Connect

    Venturi, Daniele

    2013-11-15

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  20. College Comedy and Action

    ERIC Educational Resources Information Center

    Moore, Rosanna

    1977-01-01

    A few materials such as yarn and scraps of paper and cloth can provide the media for recording limitless ideas from the imaginations of students. With a little encouragement and a few suggestions of actions, emotions, exaggerations and activities students will produce a vast array of amusing characters. (Author)

  1. Promoting Environmental Action.

    ERIC Educational Resources Information Center

    Bowyer, John

    1994-01-01

    Outlines a lesson on the extinction process allowing students to better understand why and how species become endangered before they attempt to take action on this problem. Provides background information and describes several suggested methodologies, evaluation and enrichment ideas, six resources, and two references. (LZ)

  2. Literacy Education Action.

    ERIC Educational Resources Information Center

    Clymer, Carol

    The Literacy Education Action (LEA) program was established in the fall of 1985 under the initiative of the president of the El Paso Community College (Texas). During 1985 and 1986, LEA concentrated on developing its own literacy tutoring program, including recruiting and training volunteers and community members with reading skills below the…

  3. Angels in Action

    ERIC Educational Resources Information Center

    Stylianou, Xanthippi Cynthia

    2009-01-01

    In this article, the author discusses the importance of the placement of action lines to show the direction of movement. The author shows some visuals of angels and discusses in details the texture of the wings, the hair and the clothing.

  4. Economics Action Pack.

    ERIC Educational Resources Information Center

    McDonald's Corp., Oak Brook, IL.

    One of five McDonald's Action Packs, this learning package introduces intermediate grade students to basic economic concepts. The fourteen activities include the topics of consumption (4 activities), production (5), the market system (3), a pretest, and a posttest. Specific titles under consumption include The Wonderful Treasure Tree (introduction…

  5. Sustainability as Moral Action

    ERIC Educational Resources Information Center

    Dunn, Merrily S.; Hart-Steffes, Jeanne S.

    2012-01-01

    When one considers sustainability as a moral action, there are equally complex realities at hand--climate change, resource depletion, water and land rights. One author describes this broad sense of sustainability as "the connection of specific social and environmental problems to the functioning of human and ecological systems" (Jenkins, 2011).…

  6. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City.

    As mandated by law, this 1983 revision describes the Oklahoma State Department of Education's Affirmative Action Plan and analyzes the employment patterns of the department's work force for that year in light of equal employment opportunity goals. Following a brief policy statement, the development, dissemination, and implementation of the plan…

  7. Conjugate flow action functionals

    NASA Astrophysics Data System (ADS)

    Venturi, Daniele

    2013-11-01

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  8. Holography in action

    SciTech Connect

    Kolekar, Sanved; Padmanabhan, T.

    2010-07-15

    The Einstein-Hilbert action and its natural generalizations to higher dimensions (like the Lanczos-Lovelock action) have certain peculiar features. All of them can be separated into a bulk and a surface term, with a specific (''holographic'') relationship between the two, so that either term can be used to extract information about the other. Further, the surface term leads to entropy of the horizons on shell. It has been argued in the past that these features are impossible to understand in the conventional approach but find a natural explanation if we consider gravity as an emergent phenomenon. We provide further support for this point of view in this paper. We describe an alternative decomposition of the Einstein-Hilbert action and the Lanczos-Lovelock action into a new pair of surface and bulk terms, such that the surface term becomes the Wald entropy on a horizon and the bulk term is the energy density (which is the Arnowitt-Deser-Misner Hamiltonian density for Einstein gravity). We show that this new pair also obeys a holographic relationship, and we give a thermodynamic interpretation of this relation in this context. Since the bulk and surface terms, in this decomposition, are related to the energy and entropy, the holographic condition can be thought of as analogous to inverting the expression for entropy given as a function of energy S=S(E,V) to obtain the energy E=E(S,V) in terms of the entropy in a normal thermodynamic system. Thus the holographic nature of the action allows us to relate the descriptions of the same system in terms of two different thermodynamic potentials. Some further possible generalizations and implications are discussed.

  9. Age Relationship

    NASA Technical Reports Server (NTRS)

    2006-01-01

    12 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a group of impact craters in Aonia Planum, Mars. Remarkably, two of the craters are approximately equal in size, however, they clearly differ in age. The left (west) crater has a well-defined rim and its ejecta blanket overlies part of the less pronounced crater to its immediate east. The one with the ejecta blanket is younger. Other circular depressions in this bouldery scene are also old, eroded impact craters.

    Location near: 59.5oS, 78.5oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Autumn

  10. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation...

  11. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation...

  12. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation...

  13. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation...

  14. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation...

  15. Making Tracks 1.0: Action Researching an Active Transportation Education Program

    ERIC Educational Resources Information Center

    Robinson, Daniel; Foran, Andrew; Robinson, Ingrid

    2014-01-01

    This paper reports on the results of the first cycle of an action research project. The objective of this action research was to examine the implementation of a school-based active transportation education program (Making Tracks). A two-cycle action research design was employed in which elementary school students' (ages 7-9), middle school…

  16. Aging blepharoplasty.

    PubMed

    Cho, Inchang

    2013-09-01

    In performing upper blepharoplasty in the elderly, looking younger and keeping the eyelids harmonious with the rest of the face have to be achieved at the same time. The most important goal in upper blepharoplasty for aging is correcting the drooping upper eyelid skin, and in this process, the surgeon may or may not create a double eyelid fold. The pros and cons have to be fully discussed with the patient, but the author personally prefers creating a double fold unless the patient refuses, because it is efficient in correcting and preventing further drooping of the skin. In most patients, the brow is elevated to compensate for the drooping eyelid, and when the drooping is corrected, brow ptosis may ensue. The surgeon has to prepare for these consequences before performing the procedure, and estimate the exact amount of skin to be excised. In the elderly, the skin and the orbicularis oculi muscle is thin, with a decreased amount of subcutaneous fat and retro-orbicularis oculi fat, and in most cases, excision of the skin alone is enough to correct the deformity. Removing large portions of soft tissue may also prolong the recovery period. Unlike younger patients, the lower skin flap should not be stretched too much in the elderly, as it may create an aggressive looking appearance. A few wrinkles in the lower flap should remain untouched to create a natural look. In this article, the author's own methods of performing an aging blepharoplasty are described specifically, with a step-by-step guide and surgical tips. PMID:24086798

  17. Action Planning in Typically and Atypically Developing Children (Unilateral Cerebral Palsy)

    ERIC Educational Resources Information Center

    Craje, Celine; Aarts, Pauline; Nijhuis-van der Sanden, Maria; Steenbergen, Bert

    2010-01-01

    In the present study, we investigated the development of action planning in children with unilateral Cerebral Palsy (CP, aged 3-6 years, n = 24) and an age matched control group. To investigate action planning, participants performed a sequential movement task. They had to grasp an object (a wooden play sword) and place the sword in a hole in a…

  18. Anti-aging cosmetics and its efficacy assessment methods

    NASA Astrophysics Data System (ADS)

    Li, Xiang

    2015-07-01

    The mechanisms of skin aging, the active ingredients used in anti-aging cosmetics and evaluation methods for anti-aging cosmetics were surmised in this paper. And the mechanisms of skin aging were introduced in the intrinsic and extrinsic ways. Meanwhile, the anti-aging cosmetic active ingredients were classified in accordance with the mechanism of action. Various evaluation methods such as human evaluation, in vitro evaluation were also summarized.

  19. A Metadata Action Language

    NASA Technical Reports Server (NTRS)

    Golden, Keith; Clancy, Dan (Technical Monitor)

    2001-01-01

    The data management problem comprises data processing and data tracking. Data processing is the creation of new data based on existing data sources. Data tracking consists of storing metadata descriptions of available data. This paper addresses the data management problem by casting it as an AI planning problem. Actions are data-processing commands, plans are dataflow programs and goals are metadata descriptions of desired data products. Data manipulation is simply plan generation and execution, and a key component of data tracking is inferring the effects of an observed plan. We introduce a new action language for data management domains, called ADILM. We discuss the connection between data processing and information integration and show how a language for the latter must be modified to support the former. The paper also discusses information gathering within a data-processing framework, and show how ADILM metadata expressions are a generalization of Local Completeness.

  20. Design Evolution Study - Aging Options

    SciTech Connect

    P. McDaniel

    2002-04-05

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

  1. Finding minimal action sequences with a simple evaluation of actions

    PubMed Central

    Shah, Ashvin; Gurney, Kevin N.

    2014-01-01

    Animals are able to discover the minimal number of actions that achieves an outcome (the minimal action sequence). In most accounts of this, actions are associated with a measure of behavior that is higher for actions that lead to the outcome with a shorter action sequence, and learning mechanisms find the actions associated with the highest measure. In this sense, previous accounts focus on more than the simple binary signal of “was the outcome achieved?”; they focus on “how well was the outcome achieved?” However, such mechanisms may not govern all types of behavioral development. In particular, in the process of action discovery (Redgrave and Gurney, 2006), actions are reinforced if they simply lead to a salient outcome because biological reinforcement signals occur too quickly to evaluate the consequences of an action beyond an indication of the outcome's occurrence. Thus, action discovery mechanisms focus on the simple evaluation of “was the outcome achieved?” and not “how well was the outcome achieved?” Notwithstanding this impoverishment of information, can the process of action discovery find the minimal action sequence? We address this question by implementing computational mechanisms, referred to in this paper as no-cost learning rules, in which each action that leads to the outcome is associated with the same measure of behavior. No-cost rules focus on “was the outcome achieved?” and are consistent with action discovery. No-cost rules discover the minimal action sequence in simulated tasks and execute it for a substantial amount of time. Extensive training, however, results in extraneous actions, suggesting that a separate process (which has been proposed in action discovery) must attenuate learning if no-cost rules participate in behavioral development. We describe how no-cost rules develop behavior, what happens when attenuation is disrupted, and relate the new mechanisms to wider computational and biological context. PMID:25506326

  2. Atoms in Action

    SciTech Connect

    2009-01-01

    This movie produced with Berkeley Lab's TEAM 0.5 microscope shows the growth of a hole and the atomic edge reconstruction in a graphene sheet. An electron beam focused to a spot on the sheet blows out the exposed carbon atoms to make the hole. The carbon atoms then reposition themselves to find a stable configuration. http://newscenter.lbl.gov/press-releases/2009/03/26/atoms-in-action/

  3. Empirical microeconomics action functionals

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  4. Archetypes as action patterns.

    PubMed

    Hogenson, George B

    2009-06-01

    The discovery of mirror neurons by researchers at the University of Parma promises to radically alter our understanding of fundamental cognitive and affective states. This paper explores the relationship of mirror neurons to Jung's theory of archetypes and proposes that archetypes may be viewed as elementary action patterns. The paper begins with a review of a proposed interpretation of the fainting spells of S. Freud in his relationship with Jung as an example of an action pattern that also defines an archetypal image. The challenge that mirror neurons present to traditional views in analytical psychology and psychoanalysis, however, is that they operate without recourse to a cognitive processing element. This is a position that is gaining increasing acceptance in other fields as well. The paper therefore reviews the most recent claims made by the Boston Process of Change Study Group as well as conclusions drawn from dynamic systems views of development and theoretical robotics to underline the conclusion that unconscious agency is not a requirement for coherent action. It concludes with the suggestion that this entire body of research may lead to the conclusion that the dynamic unconscious is an unnecessary hypothesis in psychoanalysis and analytical psychology. PMID:19531123

  5. Platform for Action: update.

    PubMed

    1995-01-01

    The Center for Women's Global Leadership (CWGL) has collaborated in the preparation of amendments and strategies designed to withstand the challenges being posed to the Platform for Action of the Fourth World Conference on Women. Specific challenges include the inappropriate use of the word "universal" to modify "human rights." This implies that some human rights are less than universal. The strategy proposed is to accept the use of the word "universal" in this context only when it affirms principles of universality contained in the Vienna Programme of Action and not where its use would restrict the rights to which women are entitled. A second concern is over the use of the word "equity" rather than "equality" when referring to gender relations. The use of these terms will be carefully monitored to insure that "equity" not be used to undermine the principle of gender equality. The third concern is the efforts of some governments to hinder the integration of women's human rights throughout the UN system. Such efforts will be opposed. Fourth, the CWGL will seek the inclusion of language which recognizes the barriers that different groups of women face when trying to secure their rights. Finally, the CWGL will propose inclusion of language recognizing and protecting sexual orientation rights. The CWGL is also going to work to translate the abstract language of the Platform for Action into political organizing potential to insure that governments will follow through on their agreements. PMID:12346441

  6. HHS unveils strategy for disaster response.

    PubMed

    2010-04-01

    While ED managers are intimately involved in the emergency planning processes of their hospitals, they are often unaware of how other EDs and facilities are planning for events that will affect them all. The recently announced National Health Security Strategy seeks to address that problem. Pay special attention to the objectives that address work force availability, communication, drugs and vaccines, and surveillance activities. Re-examine your connections with public health agencies and community organizations. Review the strategy and guide online, see how it applies to you, and contact national organizations to make a contribution to further its development. PMID:20391791

  7. Compulsory Attendance Policies: About Age or Intervention? SREB Focus Report

    ERIC Educational Resources Information Center

    Grove, Jeffrey

    2014-01-01

    Over the past decade, SREB state policy-makers have focused on actions to reduce dropout rates and increase high school graduation rates. Some policy-makers have suggested that raising their state's compulsory attendance age (often called the dropout age) to require students to stay in school until age 17 or 18 is an important step. However,…

  8. Action spectra for photosynthetic inhibition

    NASA Technical Reports Server (NTRS)

    Caldwell, M. M.; Flint, S.; Camp, L. B.

    1981-01-01

    The ultraviolet action spectrum for photosynthesis inhibition was determined to fall between that of the general DNA action spectrum and the generalized plant action spectrum. The characteristics of this action spectrum suggest that a combination of pronounced increase in effectiveness with decreasing wavelength, substantial specificity for the UV-B waveband, and very diminished response in the UV-A waveband result in large radiation amplification factors when the action spectra are used as weighting functions. Attempted determination of dose/response relationships for leaf disc inhibition provided inconclusive data from which to deconvolute an action spectrum.

  9. Aging, Cellular Senescence, and Cancer

    PubMed Central

    Campisi, Judith

    2014-01-01

    For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire new (albeit aberrant) functions that allow them to develop into a lethal tumor. This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence. The senescence response is widely recognized as a potent tumor suppressive mechanism. However, recent evidence strengthens the idea that it also drives both degenerative and hyper-plastic pathologies, most likely by promoting chronic inflammation. Thus, the senescence response may be the result of antagonistically pleiotropic gene action. PMID:23140366

  10. Aging, cellular senescence, and cancer.

    PubMed

    Campisi, Judith

    2013-01-01

    For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire new (albeit aberrant) functions that allow them to develop into a lethal tumor. This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence. The senescence response is widely recognized as a potent tumor suppressive mechanism. However, recent evidence strengthens the idea that it also drives both degenerative and hyperplastic pathologies, most likely by promoting chronic inflammation. Thus, the senescence response may be the result of antagonistically pleiotropic gene action. PMID:23140366

  11. 45 CFR 90.15 - Exceptions to the rules against age discrimination. Reasonable factors other than age.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Reasonable factors other than age. 90.15 Section 90.15 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... permitted to take an action otherwise prohibited by § 90.12 which is based on a factor other than age, even... based on a factor other than age only if the factor bears a direct and substantial relationship to...

  12. 45 CFR 90.15 - Exceptions to the rules against age discrimination. Reasonable factors other than age.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Reasonable factors other than age. 90.15 Section 90.15 Public Welfare Department of Health and Human Services... permitted to take an action otherwise prohibited by § 90.12 which is based on a factor other than age, even... based on a factor other than age only if the factor bears a direct and substantial relationship to...

  13. 45 CFR 90.15 - Exceptions to the rules against age discrimination. Reasonable factors other than age.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Reasonable factors other than age. 90.15 Section 90.15 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... permitted to take an action otherwise prohibited by § 90.12 which is based on a factor other than age, even... based on a factor other than age only if the factor bears a direct and substantial relationship to...

  14. 45 CFR 90.15 - Exceptions to the rules against age discrimination. Reasonable factors other than age.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... Reasonable factors other than age. 90.15 Section 90.15 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... permitted to take an action otherwise prohibited by § 90.12 which is based on a factor other than age, even... based on a factor other than age only if the factor bears a direct and substantial relationship to...

  15. 45 CFR 90.15 - Exceptions to the rules against age discrimination. Reasonable factors other than age.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Reasonable factors other than age. 90.15 Section 90.15 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... permitted to take an action otherwise prohibited by § 90.12 which is based on a factor other than age, even... based on a factor other than age only if the factor bears a direct and substantial relationship to...

  16. Improving Teaching with Collaborative Action Research: An ASCD Action Tool

    ERIC Educational Resources Information Center

    Cunningham, Diane

    2011-01-01

    Once you've established a professional learning community (PLC), you need to get this ASCD (Association for Supervision and Curriculum Development) action tool to ensure that your PLC stays focused on addressing teaching methods and student learning problems. This ASCD action tool explains how your PLC can use collaborative action research to…

  17. On the Inclusion of Externally Controlled Actions in Action Planning

    ERIC Educational Resources Information Center

    Tsai, Jessica Chia-Chin; Knoblich, Gunther; Sebanz, Natalie

    2011-01-01

    According to ideomotor theories, perceiving action effects produced by others triggers corresponding action representations in the observer. We tested whether this principle extends to actions performed by externally controlled limbs and tools. Participants performed a go-no-go version of a spatial compatibility task in which their own actions…

  18. 75 FR 9903 - Agency Information Collection Activities; Proposed Collection; Comment Request; Service; Provider...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ...; Comment Request; Service; Provider Study AGENCY: Administration on Aging, HHS. ACTION: Notice. SUMMARY... collection requirements relating to Area Agency on Aging and Local Service Provider Study. DATES: Submit... programs to seniors. This data collection focuses on two areas: an investigation of the feasibility...

  19. 75 FR 9220 - Administration on Aging Agency Information Collection Activities; Proposed Collection; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    .... ADDRESSES: Submit electronic comments on the collection of information to: lori.stalbaum@aoa.hhs.gov...-3452 or lori.stalbaum@aoa.hhs.gov . SUPPLEMENTARY INFORMATION: Under the PRA (44 U.S.C. 3501-3520.... The Program Announcement template may be found on the AoA Web site at...

  20. Developing an action concept inventory

    NASA Astrophysics Data System (ADS)

    McGinness, Lachlan P.; Savage, C. M.

    2016-06-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for incorporating expert and student feedback into successive revisions of the ACI. The student feedback, including think-aloud interviews, enabled us to identify their misconceptions about action physics.

  1. Action verbal fluency in Parkinson's patients.

    PubMed

    Rodrigues, Inês Tello; Ferreira, Joaquim J; Coelho, Miguel; Rosa, Mario M; Castro-Caldas, Alexandre

    2015-06-01

    We compared the performance of 31 non-demented Parkinson's disease (PD) patients to 61 healthy controls in an action verbal fluency task. Semantic and phonemic fluencies, cognitive impairment and behavioural dysfunction were also assessed. The mean disease duration of PD was 9.8 years (standard deviation (SD) = 6.13). There were no age (U = 899.5, p = 0.616), gender(chi-square = 0.00, p = 1.00) or literacy (U = 956, p = 0.96) differences between the two groups. A significant difference was observed between the two groups in the action verbal fluency task (U = 406.5, p < 0.01) that was not found in the other fluency tasks. The education level was the only biographical variable that influenced the action (verb) fluency outcomes, irrespective of disease duration. Our findings suggest a correlation between the disease mechanisms in PD and a specific verb deficit, support the validity of the action (verb) fluency as an executive function measure and suggest that this task provides unique information not captured with traditional executive function tasks. PMID:26083889

  2. Strong acoustic wave action

    NASA Astrophysics Data System (ADS)

    Gokhberg, M. B.

    1983-07-01

    Experiments devoted to acoustic action on the atmosphere-magnetosphere-ionosphere system using ground based strong explosions are reviewed. The propagation of acoustic waves was observed by ground observations over 2000 km in horizontal direction and to an altitude of 200 km. Magnetic variations up to 100 nT were detected by ARIEL-3 satellite near the epicenter of the explosion connected with the formation of strong field aligned currents in the magnetosphere. The enhancement of VLF emission at 800 km altitude is observed.

  3. Neurobiological actions of cysteamine

    SciTech Connect

    Brown, M.; Fisher, L.; Mason, R.T.; Rivier, J.; Vale, W.

    1985-06-01

    Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.

  4. 3RS action plan

    SciTech Connect

    Not Available

    1990-01-01

    The goal of the Solid Waste Interim Steering Committee (SWISC) process is to develop a long-term waste management system for the Greater Toronto Area (GTA), to be in place by 1996, which is environmentally, socially, economically and technically sound. This background report is being released to the public and member Regional Councils to facilitate input to the SWISC planning process. The report documents current reduction, reuse and recycling initiatives in the GTA, identifies opportunities for coordination and collaboration among the GTA communities, and develops an action plan for improving the effectiveness of the reduction, reuse and recycling efforts within the GTA.

  5. VIOLENT FRAMES IN ACTION

    SciTech Connect

    Sanfilippo, Antonio P.; McGrath, Liam R.; Whitney, Paul D.

    2011-11-17

    We present a computational approach to radical rhetoric that leverages the co-expression of rhetoric and action features in discourse to identify violent intent. The approach combines text mining and machine learning techniques with insights from Frame Analysis and theories that explain the emergence of violence in terms of moral disengagement, the violation of sacred values and social isolation in order to build computational models that identify messages from terrorist sources and estimate their proximity to an attack. We discuss a specific application of this approach to a body of documents from and about radical and terrorist groups in the Middle East and present the results achieved.

  6. Evolution in Action

    ERIC Educational Resources Information Center

    Dennis, Mike; Duggan, Adrienne; McGregor, Deb

    2014-01-01

    Evolution and inheritance appear in the new National Science Curriculum for England, which comes into effect from September 2014. In the curriculum documents, it is expected that pupils in year 6 (ages 10-11) should be taught to: (1) recognise that living things have changed over time; (2) recognise that living things produce offspring of the same…

  7. The Concept of Action Learning.

    ERIC Educational Resources Information Center

    Zuber-Skerritt, Ortrun

    2002-01-01

    Based on classic and emerging international literature, action learning is defined as learning form concrete experience and critical reflection on experience, focused on problem solving and change. Facilitators of action learning do not impose solutions but guide action learning teams through the process. (Contains 44 references.) (SK)

  8. Must Affirmative Action Be Divisive?

    ERIC Educational Resources Information Center

    Fineberg, Solomon Andhil

    1975-01-01

    Affirmative action is seen as causing dissension and cleavages in the civil rights coalition. Requisites suggested for winning support for affirmative action are thorough knowledge of its rationale and components, assuring whites they will not be pushed out of jobs, and a continued emphasis on the urgency for affirmative action. (Author/AM)

  9. Motor Execution Affects Action Prediction

    ERIC Educational Resources Information Center

    Springer, Anne; Brandstadter, Simone; Liepelt, Roman; Birngruber, Teresa; Giese, Martin; Mechsner, Franz; Prinz, Wolfgang

    2011-01-01

    Previous studies provided evidence of the claim that the prediction of occluded action involves real-time simulation. We report two experiments that aimed to study how real-time simulation is affected by simultaneous action execution under conditions of full, partial or no overlap between observed and executed actions. This overlap was analysed by…

  10. Action Research: Trends and Variations

    ERIC Educational Resources Information Center

    Beaulieu, Rodney J.

    2013-01-01

    Action research continues to grow as a research tradition, yet misconceptions about what it is and is not remains, even among scholars. For example, some mistakenly believe action research is only about professional development and is not a scholarly research approach. Some assume action research must be accomplished through a collaborative…

  11. Developing an Action Concept Inventory

    ERIC Educational Resources Information Center

    McGinness, Lachlan P.; Savage, C. M.

    2016-01-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for…

  12. Linking differences in action perception with differences in action execution

    PubMed Central

    Macerollo, A.; Bose, S.; Ricciardi, L.; Edwards, M. J.

    2015-01-01

    Successful human social interactions depend upon the transmission of verbal and non-verbal signals from one individual to another. Non-verbal social communication is realized through our ability to read and understand information present in other people’s actions. It has been proposed that employing the same motor programs, we use to execute an action when observing the same action underlies this action understanding. The main prediction of this framework is that action perception should be strongly correlated with parameters of action execution. Here, we demonstrate that subjects’ sensitivity to observed movement speeds is dependent upon how quickly they themselves executed the observed action. This result is consistent with the motor theory of social cognition and suggests that failures in non-verbal social interactions between individuals may in part result from differences in how those individuals move. PMID:25691777

  13. Aging and Aged in Organized Crime.

    ERIC Educational Resources Information Center

    Amir, Menachem

    1989-01-01

    Examines problems of the aged in organized crime, basing discussion on organized crime bosses over age 60 operating in Italy, the United States, and Israel. Looks at problems stemming from normative system in organized crime, role of the aged, intergenerational problems, fears of the aged, excuses and justifications, standards of life, and…

  14. Wave action power plant

    SciTech Connect

    Lucia, L.V.

    1982-03-16

    A wave action power plant powered by the action of water waves has a drive shaft rotated by a plurality of drive units, each having a lever pivotally mounted on and extending from said shaft and carrying a weight, in the form of a float, which floats on the waves and rocks the lever up and down on the shaft. A ratchet mechanism causes said shaft to be rotated in one direction by the weight of said float after it has been raised by wave and the wave has passed, leaving said float free to move downwardly by gravity and apply its full weight to pull down on the lever and rotate the drive shaft. There being a large number of said drive units so that there are always some of the weights pulling down on their respective levers while other weights are being lifted by waves and thereby causing continuous rotation of the drive shaft in one direction. The said levers are so mounted that they may be easily raised to bring the weights into a position wherein they are readily accessible for cleaning the bottoms thereof to remove any accumulation of barnacles, mollusks and the like. There is also provided means for preventing the weights from colliding with each other as they independently move up and down on the waves.

  15. Ovarian actions of resveratrol.

    PubMed

    Ortega, Israel; Duleba, Antoni J

    2015-08-01

    Resveratrol, a natural polyphenol found in grapes, berries, and medicinal plants, exhibits antioxidant and anti-inflammatory activities and has been proposed to be a longevity-prolonging agent. There is also growing evidence that resveratrol has cardioprotective properties and beneficial effects on both glucose and lipid metabolism. Recently, several studies have examined the use of resveratrol as a therapeutic agent to treat numerous pathological and metabolic disorders. Herein, we present insights into the mechanisms of action, biological effects, and current evidence of actions of resveratrol on the ovary. In vitro, resveratrol inhibits proliferation and androgen production by theca-interstitial cells. Resveratrol also exerts a cytostatic, but not cytotoxic, effect on granulosa cells, while decreasing aromatization and vascular endothelial growth factor expression. In vivo, resveratrol treatment reduced the size of adipocytes and improved estrus cyclicity in the previously acyclic rat model of polycystic ovary syndrome (PCOS). In addition, resveratrol increased the ovarian follicular reserve and prolonged the ovarian life span in rats. Taken together, resveratrol emerges as a potential therapeutic agent to treat conditions associated with androgen excess, such as PCOS. The efficacy of resveratrol in the treatment of gynecological conditions requires further investigation. PMID:26315293

  16. Neuroprotective Actions of Neurosteroids

    PubMed Central

    Borowicz, Kinga K.; Piskorska, Barbara; Banach, Monika; Czuczwar, Stanislaw J.

    2011-01-01

    Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation of ionotropic receptors. Neurosteroids are further subdivided into natural (produced in the brain) and synthetic. Some authors distinguish between hormonal and regular neurosteroids in the group of natural ones. The latter group, including hormone metabolites like allopregnanolone or tetrahydrodeoxycorticosterone, is devoid of hormonal activity. Both hormones and their derivatives share, however, most of the physiological functions. It is usually very difficult to distinguish the effects of hormones and their metabolites. All these substances may influence seizure phenomena and exhibit neuroprotective effects. Neuroprotection offered by steroid hormones may be realized in both genomic and non-genomic mechanisms and involve regulation of the pro- and anti-apoptotic factors expression, intracellular signaling pathways, neurotransmission, oxidative, and inflammatory processes. Since regular neurosteroids show no affinity for steroid receptors, they may act only in a non-genomic mode. Multiple studies have been conducted so far to show efficacy of neurosteroids in the treatment of the central and peripheral nervous system injury, ischemia, neurodegenerative diseases, or seizures. In this review we focused primarily on neurosteroid mechanisms of action and their role in the process of neurodegeneration. Most of the data refers to results obtained in experimental studies. However, it should be realized that knowledge about neuroactive steroids remains still incomplete and requires confirmation in clinical conditions. PMID:22649375

  17. Learning how actions function: The role of outcomes in infants' representation of events

    PubMed Central

    Perone, Sammy; Madole, Kelly L.; Oakes, Lisa M.

    2011-01-01

    Action is a fundamental component of object representations. However, little is known about how infants represent actions performed on objects. Across four experiments, we tested the hypothesis that at 10 months of age (N = 80) infants represent the general ability of actions to produce outcomes (sounds). Experiments 1A and 1B showed that infants encode actions and associate actions and object appearances in events in which actions produced no sound outcomes. Experiment 2 showed that infants associate the presence or absence of outcomes with actions. Experiment 3 showed, in contrast, that infants did not associate the presence or absence of outcomes with object appearances. Together, these studies suggest that infants encode the outcome potential of specific actions. We discuss the implications of these findings for our understanding of the development of action representations. PMID:21429585

  18. Oral Health and Aging

    MedlinePlus

    ... please turn JavaScript on. Feature: Oral Health and Aging Oral Health and Aging Summer 2016 Table of Contents Jerrold H. Epstein, ... they may need. Read More "Oral Health and Aging" Articles Oral Health and Aging / 4 Myths About ...

  19. What's Your Aging IQ?

    MedlinePlus

    ... Home » What's Your Aging IQ? Heath and Aging What's Your Aging IQ? About this booklet We all know someone " ... at the dry cleaners. But what is normal aging? In this booklet there are several very short ...

  20. The Biology of Aging.

    ERIC Educational Resources Information Center

    Sprott, Richard L.; And Others

    1992-01-01

    Thirteen articles in this special issue discuss aging theories, biomarkers of aging, aging research, disease, cancer biology, Alzheimer's disease, stress, oxidation of proteins, gene therapy, service delivery, biogerontology, and ethics and aging research. (SK)

  1. The minimalist grammar of action

    PubMed Central

    Pastra, Katerina; Aloimonos, Yiannis

    2012-01-01

    Language and action have been found to share a common neural basis and in particular a common ‘syntax’, an analogous hierarchical and compositional organization. While language structure analysis has led to the formulation of different grammatical formalisms and associated discriminative or generative computational models, the structure of action is still elusive and so are the related computational models. However, structuring action has important implications on action learning and generalization, in both human cognition research and computation. In this study, we present a biologically inspired generative grammar of action, which employs the structure-building operations and principles of Chomsky's Minimalist Programme as a reference model. In this grammar, action terminals combine hierarchically into temporal sequences of actions of increasing complexity; the actions are bound with the involved tools and affected objects and are governed by certain goals. We show, how the tool role and the affected-object role of an entity within an action drives the derivation of the action syntax in this grammar and controls recursion, merge and move, the latter being mechanisms that manifest themselves not only in human language, but in human action too. PMID:22106430

  2. Willed action and its impairments.

    PubMed

    Jahanshahi, M

    1998-09-01

    Actions are goal-directed behaviours that usually involve movem ent. There is evidence that intentional self-generated actions (willed actions) are controlled differently from routine, stereotyped actions that are externally triggered by environmental stimuli. We review evidence from investigations using positron emission tomography (PET), recordings of movement-related cortical potentials (MRCPs) or transcranial magnetic stimulation (TMS), and conclude that willed actions are controlled by a network of frontal cortical (dorsolateral prefrontal cortex, supplementary motor area, anterior cingulate) and subcortical (thalamus and basal ganglia) areas. We also consider evidence suggesting that some of the cognitive and motor deficits of patients with frontal lesions, Parkinson's disease, or schizophrenia as well as apathy and abulia and rarer phenomena such as primary obsessional slowness can be considered as reflecting im pairment of willed actions. We propose that the concept of a willed action system based on the frontostriatal circuits provides a useful framework for integrating the cognitive, motor, and motivational deficits found in these disorders. Problems remaining to be resolved include: identification of the component processes of willed actions; the specific and differential role played by each of the frontal cortical and subcortical areas in the control of willed actions; the specific mechanisms of impairm ent of willed actions in Parkinson's disease, schizophrenia, and frontal damage; and the precise role of the neurotransmitter dopamine in the willed action system. PMID:22448836

  3. Infant's action skill dynamically modulates parental action demonstration in the dyadic interaction.

    PubMed

    Fukuyama, Hiroshi; Qin, Shibo; Kanakogi, Yasuhiro; Nagai, Yukie; Asada, Minoru; Myowa-Yamakoshi, Masako

    2015-11-01

    When interacting with infants, human adults modify their behaviours in an exaggerated manner. Previous studies have demonstrated that infant-directed modification affects the infant's behaviour. However, little is known about how infant-directed modification is elicited during infant-parent interaction. We investigated whether and how the infant's behaviour affects the mother's action during an interaction. We recorded three-dimensional information of cup movements while mothers demonstrated a cup-nesting task during interaction with their infants aged 11 to 13 months. Analyses revealed that spatial characteristics of the mother's task demonstration clearly changed depending on the infant's object manipulation. In particular, the variance in the distance that the cup was moved decreased after the infant's cup nesting and increased after the infant's task-irrelevant manipulation (e.g. cup banging). This pattern was not observed for mothers with 6- to 8-month-olds, who do not have the fine motor skill to perform the action. These results indicate that the infant's action skill dynamically affects the infant-directed action and suggest that the mother is sensitive to the infant's potential to learn a novel action. A video abstract of this article can be viewed at: https://www.youtube.com/watch?v=VNS2IHwLIhg&feature=youtu.be. PMID:25483121

  4. Testing fractional action cosmology

    NASA Astrophysics Data System (ADS)

    Shchigolev, V. K.

    2016-08-01

    The present work deals with a combined test of the so-called Fractional Action Cosmology (FAC) on the example of a specific model obtained by the author earlier. In this model, the effective cosmological term is proportional to the Hubble parameter squared through the so-called kinematic induction. The reason of studying this cosmological model could be explained by its ability to describe two periods of accelerated expansion, that is in agreement with the recent observations and the cosmological inflation paradigm. First of all, we put our model through the theoretical tests, which gives a general conception of the influence of the model parameters on its behavior. Then, we obtain some restrictions on the principal parameters of the model, including the fractional index, by means of the observational data. Finally, the cosmography parameters and the observational data compared to the theoretical predictions are presented both analytically and graphically.

  5. The Quench Action

    NASA Astrophysics Data System (ADS)

    Caux, Jean-Sébastien

    2016-06-01

    We give a pedagogical introduction to the methodology of the Quench Action, which is an effective representation for the calculation of time-dependent expectation values of physical operators following a generic out-of-equilibrium state preparation protocol (for example a quantum quench). The representation, originally introduced in Caux and Essler (2013 Phys. Rev. Lett. 110 257203), is founded on a mixture of exact data for overlaps together with variational reasonings. It is argued to be quite generally valid and thermodynamically exact for arbitrary times after the quench (from short times all the way up to the steady state), and applicable to a wide class of physically relevant observables. Here, we introduce the method and its language, give an overview of some recent results, suggest a roadmap and offer some perspectives on possible future research directions.

  6. Guam Energy Action Plan

    SciTech Connect

    Conrad, M. D.; Ness, J. E.

    2013-07-01

    Describes the four near-term strategies selected by the Guam Energy Task Force during action planning workshops conducted in March 2013, and outlines the steps being taken to implement those strategies. Each strategy addresses one of the energy sectors identified in the earlier Guam strategic energy plan as being an essential component of diversifying Guam's fuel sources and reducing fossil energy consumption 20% by 2020. The four energy strategies selected are: (1) expanding public outreach on energy efficiency and conservation, (2) establishing a demand-side management revolving loan program, (3) exploring waste-to-energy options, and (4) influencing the transportation sector via anti-idling legislation, vehicle registration fees, and electric vehicles.

  7. Cardiovascular actions of berberine.

    PubMed

    Lau, C W; Yao, X Q; Chen, Z Y; Ko, W H; Huang, Y

    2001-01-01

    Berberine, is an alkaloid from Hydrastis canadensis L., Chinese herb Huanglian, and many other plants. It is widely used in traditional Chinese medicine as an antimicrobial in the treatment of dysentery and infectious diarrhea. This manuscript describes cardiovascular effects of berberine and its derivatives, tetrahydroberberine and 8-oxoberberine. Berberine has positive inotropic, negative chronotropic, antiarrhythmic, and vasodilator properties. Both derivatives of berberine have antiarrhythmic activity. Some cardiovascular effects of berberine and its derivatives are attributed to the blockade of K+ channels (delayed rectifier and K(ATP)) and stimulation of Na+ -Ca(2+) exchanger. Berberine has been shown to prolong the duration of ventricular action potential. Its vasodilator activity has been attributed to multiple cellular mechanisms. The cardiovascular effects of berberine suggest its possible clinical usefulness in the treatment of arrhythmias and/or heart failure. PMID:11607041

  8. Age distribution among NASA scientists and engineers

    NASA Technical Reports Server (NTRS)

    Ciancone, Michael L.

    1989-01-01

    The loss of technical expertise through attrition in NASA and the aerospace industry is discussed. This report documents historical age-related information for scientific and engineering personnel in general and the NASA Lewis Research Center in particular, for 1968 through 1987. Recommendations are made to promote discussion and to establish the groundwork for action.

  9. The Age Discrimination Study. Part 2.

    ERIC Educational Resources Information Center

    Flemming, Arthur S.; And Others

    By the Older Americans Amendments of 1975, the U.S. Commission on Civil Rights was directed to investigate unreasonable age discrimination in federally-assisted programs, report the findings and recommend statutory changes for administrative actions. Results of examinations of the literature, field studies and public hearings on the following…

  10. Everyday robotic action: lessons from human action control

    PubMed Central

    de Kleijn, Roy; Kachergis, George; Hommel, Bernhard

    2014-01-01

    Robots are increasingly capable of performing everyday human activities such as cooking, cleaning, and doing the laundry. This requires the real-time planning and execution of complex, temporally extended sequential actions under high degrees of uncertainty, which provides many challenges to traditional approaches to robot action control. We argue that important lessons in this respect can be learned from research on human action control. We provide a brief overview of available psychological insights into this issue and focus on four principles that we think could be particularly beneficial for robot control: the integration of symbolic and subsymbolic planning of action sequences, the integration of feedforward and feedback control, the clustering of complex actions into subcomponents, and the contextualization of action-control structures through goal representations. PMID:24672474

  11. Prolonged contraction duration in aged myocardium.

    PubMed

    Lakatta, E G; Gerstenblith, G; Angell, C S; Shock, N W; Weisfeldt, M L

    1975-01-01

    Isometric performance at 29degreesC was measured in left ventricular trabeculae carneae from young adult (6-mo) and aged (25-mo) rats (n equals 18 in each group). Active tension and maximal rate of tension development did not differ with age, but contraction duration was 255plus or minus6 ms in the young adult and 283plus or minus6 ms in the aged group (P less than0.001). Although catecholamine content per gram heart weight was less in the aged myocardium, additional experiments showed that neither 1 times 10-6 M propranolol nor pretreatment with 6-hydroxydopamine eliminated the age difference in contraction duration. To determine if this age difference resulted from a prolonged active state, electromechanical dissociation and the overshoot of contraction duration during recovery from hypoxia were measured. During paired stimulation greater mechanical refractoriness was found in aged muscles (P less than0.01), but intracellular action potential recordings showed no age difference in the electrical refractory period. On recovery from hypoxia, contraction duration overshoot was 117plus or minus 4percent of control in the young and 138plus or minus 4percent of control in the aged muscles (P less than0.01). The greater electromechanical dissociation and greater overshoot in contraction duration following hypoxia in aged myocardium suggests that prolonged contraction duration in aged myocardium results from a prolonged active state rather than changes in passive properties or myocardial catecholamine content. PMID:1109181

  12. [Fundamental aspects of extreme aging].

    PubMed

    Tréton, J

    2002-07-01

    Major developments in molecular biology in invertebrates have recently shown the determining effect of genetics on aging. The first finding was that artificial selection can highlight the genetic aspect of the aging process, demonstrating the polygenetic property of longevity. Another finding showed that certain gene transfers can modulate the lifespan of an organism. Recent progress has been made in three fields: genetic markers of aging, biological basis of cell maintenance, and hereditary factors contributing to late onset genetic disease. These new developments open new avenues of research in clinical biology. In regard to genetic markers of aging, it has been demonstrated that the ends of the chromosomes, telomeres, play a role in cell senescence. Telomeres can be viewed as markers of aging. Shortened telomeres are associated with replicative senescence and antitumor action. DNA anomalies are also more frequent: simple or double breaks, additions and base substitutions. Data on the biological basis of cell maintenance obtained in invertebrates show the polygenetic property of aging involving four significant mechanisms, control of metabolism, resistance to stress, chromatin-dependent gene regulation of genetic homeostasis. Finally, recent studies have shown that late onset hereditary diseases would be linked with particular genes, some of which have been identified. Two non-exclusive mechanisms could be involved: an adaptive mechanism involving gene selection during the evolutionary process, for example in obesity; and non-adaptive accumulation of gene expression during the post-reproductive phase, for example in Alzheimer's disease. These findings open a new era for the biology of aging. PMID:12596689

  13. [Noradrenaline and cerebral aging].

    PubMed

    Jouvet, M; Albarede, J L; Lubin, S; Meyrignac, C

    1991-01-01

    The central functions of norepinephrine (NE) are a recent discovery: regulation of alertness and of the wakefulness-sleep cycle, maintenance of attention, memory and learning, cerebral plasticity and neuro-protection. The anatomical, histological, biochemical and physiological properties of the central noradrenergic system: extreme capacity for ramification and arborization; slow conduction, non-myelinized axons with extrasynaptic varicosities producing and releasing NE; frequency of co-transmission phenomena, and; neuromodulation with fiber effect responsible for improvement in the signal over background noise ratio and selection of significant stimuli form a true interface between the outside world and the central nervous system, notably for the neocortex in the context of the cognitive treatment of information. This central noradrenergic system is involved in the neurophysiology and the clinical features of cerebral aging (ideation-motor and cognitive function slowing down, loss of behavioral adjustment), neuro-degenerative disorders (SDAT, Parkinson's disease), certain aspects of depression and less obvious conditions (head injuries, sequelae of cerebrovascular accidents, sub-cortical dementia). The recent development of medications improving alertness (adrafinil, modafinil) with a pure central action and specifically noradrenergic, may contribute to an improvement in these multifactorial disorders. PMID:1864252

  14. Ageing aircraft research in the Netherlands

    NASA Technical Reports Server (NTRS)

    Dejonge, J. B.; Bartelds, G.

    1992-01-01

    The problems of aging aircraft are worldwide. Hence, international cooperative actions to overcome or prevent problems should be taken. The Federal Aviation Administration (FAA) and the Netherlands Civil Aviation Department (RLD) signed a Memorandum of Cooperation in the area of structural integrity, with specific reference to research on problems in the area of aging aircraft. Here, an overview is given of aging research that is going on in the Netherlands. The work described is done largely at the National Aerospace Laboratory; much of the research is part of the forementioned cooperative agreement.

  15. On "action language" in psychoanalysis.

    PubMed

    Calogeras, R C; Alston, T M

    1980-10-01

    The main tenets of action language are summarized in an attempt to discern the direction in which psychoanalysis might go if action language becomes the "new metapsychology." The principal roots of action language are traced to the different linguistic/language and personality-and-culture models of anthropology and to the neobehaviorist currents of academic psychology. The authors' findings support the hypothesis that action language is a form os psychoanalytic behaviorism having idealism, logical positivism, and radical empiricism as its philosophical underpinnings. Its adoption would confound the entire motivational aspect of psychoanalysis. Specifically, the authors suggest that action language falls under the aegis of Wittgenstein's family of language games. When the action language game is said to be brought to a successful resolution, the language game disappears and, supposedly, so do the patient's conflicts. PMID:7422749

  16. Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

    PubMed Central

    Salmon, Adam B.; Richardson, Arlan; Pérez, Viviana I.

    2010-01-01

    The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is lifespan, i.e., does altering oxidative stress/damage change lifespan? Mice with genetic manipulations in the antioxidant defense system designed to directly address this prediction have, with few exceptions, shown no change in lifespan. However, when these transgenic/knockout mice are tested using models that develop various types of age-related pathology, they show alterations in progression and/or severity of pathology as predicted by the oxidative stress theory; increased oxidative stress accelerates pathology and reduced oxidative stress retards pathology. These contradictory observations might mean a) oxidative stress plays a very limited, if any, role in aging but a major role in healthspan; and/or b) the role that oxidative stress plays in aging depends on environment. In environments with minimal stress, as expected under optimal husbandry, oxidative damage plays little role in aging. However, under chronic stress, including pathological phenotypes that diminish optimal health, oxidative stress/damage plays a major role in aging. Under these conditions, enhanced antioxidant defenses exert an “anti-aging” action, leading to changes in lifespan, age-related pathology, and physiological function as predicted by the oxidative stress theory of aging. PMID:20036736

  17. Action programme for youth.

    PubMed

    Sulaiman, A B

    1993-01-01

    In Nigeria, where abortion is illegal, unmarried women under 20 years of age comprises the majority of abortion patients and complications from unsafe abortion represent a major health problem among this sector. The high incidence of abortion in Nigeria reflects increased premarital sex activity in urban areas; opposition to family planning, and cultural sanctions against single parenting or forced marriage. The Planned Parenthood Federation of Nigeria (PPFN) is working, cautiously, toward liberalization of the grounds for legal abortion; however, its major strategy is to avert the need for abortion through overcoming opposition to family planning services for young people and family life education in the schools. To reach young people, PPFN has begun providing services in medical clinics attached to vocational schools and institutes of higher education. The concept of using peers to distribute non-prescription contraceptives is being considered, and special youth clinics are planned for urban areas. About 5% of new acceptors at PPFN clinics are under 20 years of age, and attempts are being made to tailor services to the unique needs of this population. PMID:12345327

  18. Object and Action Naming in Children With Specific Language Impairment

    PubMed Central

    Sheng, Li; McGregor, Karla K.

    2012-01-01

    Purpose In this study, the authors aimed to examine the accuracy, latency, and errors of noun (object) and verb (action) naming in children with and without specific language impairment (SLI) and to determine whether children with SLI have a particularly large noun–verb performance gap. Method Children with SLI, age-matched peers (AM), and expressive vocabulary–matched peers (VM) named 120 matched object and action pictures in a computerized confrontation naming task. Results The SLI and VM groups demonstrated comparable naming latency and accuracy; both were slower and less accurate than the AM group. Object naming was more accurate than action naming in the SLI and VM groups; their noun–verb performance gaps were comparable. Object naming was faster than action naming in all children. In comparison with the AM group, the SLI group made proportionally fewer taxonomic errors and more omission errors when naming objects, and fewer misperception errors when naming actions. Conclusions The naming abilities of children with SLI, although deficient given their chronological age, are commensurate with their vocabulary level. Their naming errors suggest immaturities in semantic representation. Action naming is significantly more difficult than object naming, but the noun–verb gap that characterizes the performance of children with SLI is appropriate for their vocabulary level. PMID:20705739

  19. Avoiding Aging? Social Psychology's Treatment of Age

    ERIC Educational Resources Information Center

    Barrett, Anne E.; Redmond, Rebecca; von Rohr, Carmen

    2012-01-01

    Population aging, in conjunction with social and cultural transformations of the life course, has profound implications for social systems--from large-scale structures to micro-level processes. However, much of sociology remains fairly quiet on issues of age and aging, including the subfield of social psychology that could illuminate the impact of…

  20. 22 CFR 223.11 - Appropriate action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Appropriate action. 223.11 Section 223.11...-EMPLOYMENT RESTRICTIONS § 223.11 Appropriate action. The Administrator may take appropriate action in the... action....