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Sample records for aging hhs action

  1. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in § 93.501, the ORI finding of research misconduct is the final HHS action on the research misconduct issues and the HHS administrative actions become final and will be implemented, except that...

  2. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... Subparts 9.4 and 309.4, or both. (b) In connection with findings of research misconduct, HHS also may...

  3. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false HHS compliance actions. 93.413 Section 93.413 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  4. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  5. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  6. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false HHS compliance actions. 93.413 Section 93.413 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  7. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... 42 Public Health 1 2013-10-01 2013-10-01 false Final HHS actions. 93.406 Section 93.406 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

  8. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  9. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false HHS compliance actions. 93.413 Section 93.413 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  10. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false HHS compliance actions. 93.413 Section 93.413 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  11. 42 CFR 93.413 - HHS compliance actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false HHS compliance actions. 93.413 Section 93.413 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  12. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS actions. 93.406 Section 93.406 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

  13. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... 42 Public Health 1 2012-10-01 2012-10-01 false Final HHS actions. 93.406 Section 93.406 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

  14. 42 CFR 93.406 - Final HHS actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... 42 Public Health 1 2011-10-01 2011-10-01 false Final HHS actions. 93.406 Section 93.406 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND...

  15. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  16. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a settlement or finding of... 42 Public Health 1 2011-10-01 2011-10-01 false Final HHS action with no settlement or finding...

  17. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or finding of research misconduct. When a final HHS action results in a settlement or research misconduct... 42 Public Health 1 2011-10-01 2011-10-01 false Final HHS action with settlement or finding...

  18. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any...

  19. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any...

  20. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any...

  1. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any...

  2. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or finding... 42 Public Health 1 2012-10-01 2012-10-01 false Final HHS action with settlement or finding of research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  3. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or finding... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS action with settlement or finding of research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  4. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or... 42 Public Health 1 2014-10-01 2014-10-01 false Final HHS action with no settlement or finding of research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  5. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or finding... 42 Public Health 1 2013-10-01 2013-10-01 false Final HHS action with settlement or finding of research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  6. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or... 42 Public Health 1 2013-10-01 2013-10-01 false Final HHS action with no settlement or finding of research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  7. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or... 42 Public Health 1 2012-10-01 2012-10-01 false Final HHS action with no settlement or finding of research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

  8. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... rather than accepting responsibility for the actions? (f) Retaliation. Did the respondent retaliate... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health... administrative actions. The purpose of HHS administrative actions is remedial. The appropriate...

  9. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... rather than accepting responsibility for the actions? (f) Retaliation. Did the respondent retaliate... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health... administrative actions. The purpose of HHS administrative actions is remedial. The appropriate...

  10. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... rather than accepting responsibility for the actions? (f) Retaliation. Did the respondent retaliate... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health... administrative actions. The purpose of HHS administrative actions is remedial. The appropriate...

  11. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... rather than accepting responsibility for the actions? (f) Retaliation. Did the respondent retaliate... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health... administrative actions. The purpose of HHS administrative actions is remedial. The appropriate...

  12. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.408 Mitigating and aggravating factors in HHS... action is commensurate with the seriousness of the misconduct, and the need to protect the health...

  13. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  14. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement...

  15. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding of research misconduct or seeks to impose or enforce HHS administrative actions, other than debarment or... 42 Public Health 1 2011-10-01 2011-10-01 false Notifying the respondent of findings of...

  16. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH SERVICE... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent...

  17. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of... 42 Public Health 1 2014-10-01 2014-10-01 false Notifying the respondent of findings of research misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH...

  18. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of... 42 Public Health 1 2012-10-01 2012-10-01 false Notifying the respondent of findings of research misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH...

  19. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of... 42 Public Health 1 2013-10-01 2013-10-01 false Notifying the respondent of findings of research misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH...

  20. The HHS Mandate and Religious Liberty: A Primer

    ERIC Educational Resources Information Center

    Keim, Adele Auxier

    2013-01-01

    "We are in a war," Health and Human Services Secretary Kathleen Sebelius declared to cheers at a 2011 National Abortion and Reproductive Rights Action League (NARAL) Pro-Choice America fund-raiser. Secretary Sebelius was referring in part to the uproar caused by the "HHS Mandate," her agency's rule that employer-provided…

  1. 78 FR 48170 - Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... Services Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer... Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the....Wesolowski@cms.hhs.gov . SUPPLEMENTARY INFORMATION: The Computer Matching and Privacy Protection Act of...

  2. Age effects on rotational hand action.

    PubMed

    Varadhan, S K M; Zhang, Wei; Zatsiorsky, Vladimir M; Latash, Mark L

    2012-06-01

    We investigated age-related differences in finger coordination during rotational hand actions. Two hypotheses based on earlier studies were tested: higher safety margins and lower synergy indices were expected in the elderly. Young and elderly subjects held a handle instrumented with five six-component force sensors and performed discrete accurate pronation and supination movements. The weight of the system was counterbalanced with another load. Indices of synergies stabilizing salient performance variables, such as total normal force, total tangential force, moments produced by these forces, and total moment of force were computed at two levels of a hypothetical control hierarchy, at the virtual finger-thumb level and at the individual finger level. At each level, synergy indices reflected the normalized difference between the sum of the variances of elemental variables and variance of their combined output, both computed at comparable phases over repetitive trials. The elderly group performed the task slower and showed lower safety margins for the thumb during the rotation phase. Overall, the synergy indices were not lower in the elderly group. In several cases, these indices were significantly higher in the elderly than in the younger participants. Hence, both main hypotheses have been falsified. We interpret the unexpectedly low safety margins in the elderly as resulting from several factors such as increased force variability, impaired feed-forward control, and the fact that there was no danger of dropping the object. Our results suggest that in some natural tasks, such as the one used in this study, healthy elderly persons show no impairment, as compared to younger persons, in their ability to organize digits into synergies stabilizing salient performance variables.

  3. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  4. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  5. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true HHS participation. 41.6 Section 41.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  6. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency for Healthcare Research and Quality; (4) Agency for Toxic Substances and Disease Registry; (5) Centers...

  7. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency for Healthcare Research and Quality; (4) Agency for Toxic Substances and Disease Registry; (5) Centers...

  8. 76 FR 14669 - Privacy Act of 1974; CMS Computer Match No. 2011-02; HHS Computer Match No. 1007

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2011-02; HHS Computer Match No. 1007 AGENCY: Department of Health and Human Services (HHS), Centers for Medicare & Medicaid Services (CMS). ACTION: Notice of computer matching program. SUMMARY: In...

  9. 78 FR 39730 - Privacy Act of 1974; CMS Computer Match No. 2013-11; HHS Computer Match No. 1302

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-11; HHS Computer Match No. 1302 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY:...

  10. 78 FR 73195 - Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching Program Match No. 1312 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer...

  11. 78 FR 49525 - Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY:...

  12. 78 FR 49524 - Privacy Act of 1974; CMS Computer Match No. 2013-08; HHS Computer Match No. 1309

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-08; HHS Computer Match No. 1309 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY:...

  13. 78 FR 50419 - Privacy Act of 1974; CMS Computer Match No. 2013-10; HHS Computer Match No. 1310

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-10; HHS Computer Match No. 1310 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY:...

  14. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1 Location of HHS regulations. Regulations for HHS's programs and activities are located in several different titles of the Code of Federal Regulations:...

  15. The effects of an action's "age-of-acquisition" on action-sentence processing.

    PubMed

    Gilead, Michael; Liberman, Nira; Maril, Anat

    2016-11-01

    How does our brain allow us comprehend abstract/symbolic descriptions of human action? Whereas past research suggested that processing action language relies on sensorimotor brain regions, recent work suggests that sensorimotor activation depends on participants' task goals, such that focusing on abstract (vs. concrete) aspects of an action activates "default mode network" (rather than sensorimotor) regions. Following a Piagetian framework, we hypothesized that for actions acquired at an age wherein abstract/symbolic cognition is fully-developed, even when participants focus on the concrete aspects of an action, they should retrieve abstract-symbolic mental representations. In two studies, participants processed the concrete (i.e., "how") and abstract (i.e., "why") aspects of late-acquired and early-acquired actions. Consistent with previous research, focusing on the abstract (vs. concrete) aspects of an action resulted in greater activation in the "default mode network". Importantly, the activation in these regions was higher when processing later-acquired (vs. earlier acquired) actions-also when participants' goal was to focus on the concrete aspects of the action. We discuss the implications of the current findings to research on the involvement of concrete representations in abstract cognition.

  16. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... this subpart, and to provide the Director with technical assistance in conducting such feasibility... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.6 HHS participation. The...

  17. Impaired acquisition of goal-directed action in healthy aging.

    PubMed

    de Wit, S; van de Vijver, I; Ridderinkhof, K R

    2014-06-01

    According to dual-system theories, instrumental learning is supported by dissociable goal-directed and habitual systems. Previous investigations of the dual-system balance in healthy aging have yielded mixed results. To further investigate this issue, we compared performance of young (17-24 years) and older (69-84 years) adults on an instrumental learning task. Following the initial learning phase, the behavioral autonomy of the motivational significance of the instrumental outcome was assessed with an outcome-devaluation test and slips-of-action test. The present study provides evidence for a disrupted dual-system balance in healthy aging, as reflected in reduced outcome-induced conflict during acquisition, as well as in impaired performance during the test stage, during which participants had to flexibly adjust their actions to changes in the current desirability of the behavioral outcome. These findings will be discussed in relation to previous aging studies into habitual and goal-directed control, as well as other cognitive impairments, challenges that older adults may face in everyday life, and to the neurobiological basis of the developmental pattern of goal-directed action across the lifespan.

  18. 48 CFR 302.7100 - HHS standard templates and formats.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... GENERAL DEFINITIONS OF WORDS AND TERMS HHS Standard Templates and Formats 302.7100 HHS standard templates..., may be accessed on the ASFR/OGAPA/DA Internet Web site. A complete listing of the standard...

  19. Patricia Hartge Receives the HHS Career Achievement Award

    Cancer.gov

    In February 2012, Patricia Hartge, Sc.D., Deputy Director of DCEG’s Epidemiology and Biostatistics Program, received the Department of Health and Human Services (HHS) Career Achievement Award at the HHS Honor Awards Ceremony.

  20. 78 FR 42080 - Privacy Act of 1974; CMS Computer Match No. 2013-07; HHS Computer Match No. 1303; DoD-DMDC Match...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-07; HHS Computer Match No. 1303; DoD-DMDC Match No. 18 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching...

  1. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... titles of the Code of Federal Regulations: • Regulations having HHS-wide application or which the...

  2. Mobility and Aging: New Directions for Public Health Action

    PubMed Central

    Guralnik, Jack M.; Jackson, Richard J.; Marottoli, Richard A.; Phelan, Elizabeth A.; Prohaska, Thomas R.

    2012-01-01

    Optimal mobility, defined as relative ease and freedom of movement in all of its forms, is central to healthy aging. Mobility is a significant consideration for research, practice, and policy in aging and public health. We examined the public health burdens of mobility disability, with a particular focus on leading public health interventions to enhance walking and driving, and the challenges and opportunities for public health action. We propose an integrated mobility agenda, which draws on the lived experience of older adults. New strategies for research, practice, and policy are needed to move beyond categorical promotion programs in walking and driving to establish a comprehensive program to enhance safe mobility in all its forms. PMID:22698013

  3. Five Years of HHS Home Health Care Evaluations: Using Evaluation to Change National Policy

    ERIC Educational Resources Information Center

    Brandon, Paul R.; Smith, Nick L.; Grob, George F.

    2012-01-01

    In 1997, American Evaluation Association member George Grob, now retired from the U.S. Department of Health and Human Services (HHS) and currently President of the Center for Public Program Evaluation, made a testimony on Medicare home health care fraud and abuse before the U.S. Senate Special Committee on Aging. The occasion was to announce the…

  4. 5 CFR 5501.102 - Designation of HHS components as separate agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... remainder of HHS: (1) Administration on Aging; (2) Administration for Children and Families: (3) Agency for... Disease Control and Prevention; (6) Centers for Medicare and Medicaid Services; (7) Food and Drug... identify an employee's “agency” for purposes of: (1) Determining when a person is a prohibited...

  5. On the enigma of carnosine's anti-ageing actions.

    PubMed

    Hipkiss, Alan R

    2009-04-01

    Carnosine (beta-alanyl-L-histidine) has described as a forgotten and enigmatic dipeptide. Carnosine's enigma is particularly exemplified by its apparent anti-ageing actions; it suppresses cultured human fibroblast senescence and delays ageing in senescence-accelerated mice and Drosophila, but the mechanisms responsible remain uncertain. In addition to carnosine's well-documented anti-oxidant, anti-glycating, aldehyde-scavenging and toxic metal-ion chelating properties, its ability to influence the metabolism of altered polypeptides, whose accumulation characterises the senescent phenotype, should also be considered. When added to cultured cells, carnosine was found in a recent study to suppress phosphorylation of the translational initiation factor eIF4E resulting in decreased translation frequency of certain mRNA species. Mutations in the gene coding for eIF4E in nematodes extend organism lifespan, hence carnosine's anti-ageing effects may be a consequence of decreased error-protein synthesis which in turn lowers formation of protein carbonyls and increases protease availability for degradation of polypeptides altered postsynthetically. Other studies have revealed carnosine-induced upregulation of stress protein expression and nitric oxide synthesis, both of which may stimulate proteasomal elimination of altered proteins. Some anti-convulsants can enhance nematode longevity and suppress the effects of a protein repair defect in mice, and as carnosine exerts anti-convulsant effects in rodents, it is speculated that the dipeptide may participate in the repair of protein isoaspartyl groups. These new observations only add to the enigma of carnosine's real in vivo functions. More experimentation is clearly required.

  6. 42 CFR 52d.8 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations that apply. 52d.8 Section 52d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL CANCER INSTITUTE CLINICAL CANCER EDUCATION PROGRAM § 52d.8 Other HHS regulations that apply....

  7. 42 CFR 52d.8 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations that apply. 52d.8 Section 52d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL CANCER INSTITUTE CLINICAL CANCER EDUCATION PROGRAM § 52d.8 Other HHS regulations that apply....

  8. 42 CFR 52d.8 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 52d.8 Section 52d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL CANCER INSTITUTE CLINICAL CANCER EDUCATION PROGRAM § 52d.8 Other HHS regulations that apply....

  9. 42 CFR 52d.8 - Other HHS regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 52d.8 Section 52d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL CANCER INSTITUTE CLINICAL CANCER EDUCATION PROGRAM § 52d.8 Other HHS regulations that apply....

  10. 42 CFR 52d.8 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations that apply. 52d.8 Section 52d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL CANCER INSTITUTE CLINICAL CANCER EDUCATION PROGRAM § 52d.8 Other HHS regulations that apply....

  11. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  12. 42 CFR 52c.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations that apply. 52c.7 Section 52c.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH SUPPORT PROGRAM § 52c.7 Other HHS regulations that apply. Several other regulations...

  13. 42 CFR 52c.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations that apply. 52c.7 Section 52c.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH SUPPORT PROGRAM § 52c.7 Other HHS regulations that apply. Several other regulations...

  14. 42 CFR 52c.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 52c.7 Section 52c.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH SUPPORT PROGRAM § 52c.7 Other HHS regulations that apply. Several other regulations...

  15. 42 CFR 52c.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 52c.7 Section 52c.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH SUPPORT PROGRAM § 52c.7 Other HHS regulations that apply. Several other regulations...

  16. 42 CFR 52c.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations that apply. 52c.7 Section 52c.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH SUPPORT PROGRAM § 52c.7 Other HHS regulations that apply. Several other regulations...

  17. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Adoption of HHS regulations. 605.0 Section 605.0 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and...

  18. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Adoption of HHS regulations. 605.0 Section 605.0 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and...

  19. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Adoption of HHS regulations. 605.0 Section 605.0 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and...

  20. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Adoption of HHS regulations. 605.0 Section 605.0 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and...

  1. 45 CFR 605.0 - Adoption of HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Adoption of HHS regulations. 605.0 Section 605.0 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and...

  2. 78 FR 5182 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  3. 77 FR 4034 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  4. 76 FR 3637 - Annual Update of the HHS Poverty Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, State, or local office that is responsible for that program. For information about...

  5. 42 CFR 1007.21 - Other applicable HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Other applicable HHS regulations. 1007.21 Section 1007.21 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES STATE MEDICAID FRAUD CONTROL UNITS § 1007.21 Other applicable HHS regulations....

  6. 42 CFR 64.9 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations that apply. 64.9 Section 64.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.9 Other HHS regulations that apply....

  7. 42 CFR 64.9 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 64.9 Section 64.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.9 Other HHS regulations that apply....

  8. 42 CFR 64.9 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations that apply. 64.9 Section 64.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.9 Other HHS regulations that apply....

  9. 42 CFR 64.9 - Other HHS regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 64.9 Section 64.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.9 Other HHS regulations that apply....

  10. 42 CFR 64.9 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations that apply. 64.9 Section 64.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.9 Other HHS regulations that apply....

  11. 42 CFR 59a.17 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations...

  12. 42 CFR 59a.17 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations...

  13. 42 CFR 59a.17 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations...

  14. 42 CFR 59a.17 - Other HHS regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations...

  15. 42 CFR 59a.17 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations...

  16. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS). ACTION... (CDC), located within the Department of Health and Human Services (HHS) published a notice in the... be received on or before June 15, 2012. HHS/CDC has received a request asking for a 30 day...

  17. Age, Action Orientation, and Self-Regulation during the Pursuit of a Dieting Goal.

    PubMed

    Hennecke, Marie; Freund, Alexandra M

    2016-03-01

    Two studies tested the hypotheses that (1) action orientation (vs. state orientation) is positively correlated with age across adulthood and (2) action orientation aids the self-regulation of one's feelings, thoughts, and behavior during the pursuit of a dieting goal. Hypotheses were partly confirmed. In Study 1, N = 126 overweight women (age: 19-77 years) intended to lose weight by means of a low-calorie diet. In Study 2, N = 322 adults (age: 18-82 years) reported on their action orientation to replicate the association of age and action orientation found in Study 1. Study 2 corroborated only the expected positive association of age and decision-related action orientation. In Study 1, decision-related action orientation predicted higher affective well-being during the diet as well as less self-reported deviations from the diet; failure-related action orientation predicted lower levels of rumination in response to dieting failures. Action orientation partially mediated the negative effects of age on deviations and rumination (see Hennecke & Freund, ). Weight loss was not predicted by action orientation. We discuss action orientation as one factor of increased motivational competence in older adulthood.

  18. Anticipatory Action Planning Increases from 3 to 10 Years of Age in Typically Developing Children

    ERIC Educational Resources Information Center

    Jongbloed-Pereboom, Marjolein; Nijhuis-van der Sanden, Maria W. G.; Saraber-Schiphorst, Nicole; Craje, Celine; Steenbergen, Bert

    2013-01-01

    The primary aim of this study was to assess the development of action planning in a group of typically developing children aged 3 to 10 years (N = 351). The second aim was to assess reliability of the action planning task and to relate the results of the action planning task to results of validated upper limb motor performance tests. Participants…

  19. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... have been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria..., and Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the...

  20. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... have been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria..., and Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the...

  1. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... administer acquisitions that involve electronic information technology (EIT) products or services (subject...

  2. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... administer acquisitions that involve electronic information technology (EIT) products or services (subject...

  3. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... administer acquisitions that involve electronic information technology (EIT) products or services (subject...

  4. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... administer acquisitions that involve electronic information technology (EIT) products or services (subject...

  5. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... administer acquisitions that involve electronic information technology (EIT) products or services (subject...

  6. 78 FR 56706 - HHS Retrospective Review 2013 Request for Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... administration burdens; Achieve better results by modifying, streamlining, expanding, or eliminating rules when the costs or benefits are greater than originally anticipated; Eliminate rules that are outdated... existing regulations HHS should consider reviewing in order to streamline or eliminate...

  7. The timing and precision of action prediction in the aging brain

    PubMed Central

    Jones, Alex L.; Cross, Emily S.

    2015-01-01

    Abstract Successful social interactions depend on the ability to anticipate other people's actions. Current conceptualizations of brain function propose that causes of sensory input are inferred through their integration with internal predictions generated in the observer's motor system during action observation. Less is known concerning how action prediction changes with age. Previously we showed that internal action representations are less specific in older compared with younger adults at behavioral and neural levels. Here, we characterize how neural activity varies while healthy older adults aged 56–71 years predict the time‐course of an unfolding action as well as the relation to task performance. By using fMRI, brain activity was measured while participants observed partly occluded actions and judged the temporal coherence of the action continuation that was manipulated. We found that neural activity in frontoparietal and occipitotemporal regions increased the more an action continuation was shifted backwards in time. Action continuations that were shifted towards the future preferentially engaged early visual cortices. Increasing age was associated with neural activity that extended from posterior to anterior regions in frontal and superior temporal cortices. Lower sensitivity in action prediction resulted in activity increases in the caudate. These results imply that the neural implementation of predicting actions undergoes similar changes as the neural process of executing actions in older adults. The comparison between internal predictions and sensory input seems to become less precise with age leading to difficulties in anticipating observed actions accurately, possibly due to less specific internal action models. Hum Brain Mapp 37:54–66, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. PMID:26503586

  8. Age-related macular degeneration: Complement in action.

    PubMed

    van Lookeren Campagne, Menno; Strauss, Erich C; Yaspan, Brian L

    2016-06-01

    The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD.

  9. 76 FR 14402 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... To Combat Antimicrobial Resistance AGENCY: Centers for Disease Control and Prevention (CDC... Action Plan to Combat Antimicrobial Resistance. HHS/CDC is publishing this notice on behalf of the HHS Interagency Task Force on Antimicrobial Resistance. The draft Action Plan and supporting documents can...

  10. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

    SciTech Connect

    Nagai, Rhoji; Murray, David B.; Metz, Thomas O.; Baynes, John

    2012-03-01

    Advanced glycation or glycoxidation end-products (AGE) increase in tissue proteins with age, and their rate of accumulation is increased in diabetes, nephropathy and inflammatory diseases. AGE inhibitors include a range of compounds that are proposed to act by trapping carbonyl and dicarbonyl intermediates in AGE formation. However, some among the newer generation of AGE inhibitors lack reactive functional groups that would trap reaction intermediates, indicating an alternative mechanism of action. We propose that AGE inhibitors function primarily as chelators, inhibiting metal-catalyzed oxidation reactions. The AGE-inhibitory activity of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers is also consistent with their chelating activity. Finally, compounds described as AGE breakers, or their hydrolysis products, also have strong chelating activity, suggesting that these compounds also act through their chelating activity. We conclude that chelation is the common, and perhaps the primary, mechanism of action of AGE inhibitors and breakers, and that chronic, mild chelation therapy should prove useful in treatment of diabetes and age-related diseases characterized by oxidative stress, inflammation and increased chemical modification of tissue proteins by advanced glycoxidation and lipoxidation end-products.

  11. Mature age students access, entry and success in nurse education: an action research study.

    PubMed

    Kenny, Amanda; Kidd, Tracy; Nankervis, Katrina; Connell, Sarah

    2011-01-01

    This action research study involved an 'expert group' that was convened to consider issues for mature age nursing students in the Australian context and develop recommendations that could be used to strengthen mature age entry, access and success in nursing programs. Consistent with action research, the group worked through phases of planning, action, observation, evaluation and critical reflection. In developing recommendations that could be used for future planning, the group met regularly, reviewed extensive literature, and conducted two data collection activities, a questionnaire and focus group with education providers. From the action research activities, five major recommendations were generated. These focused on the value of mature age students, the need for specific information, transparent and clear processes for students entering nurse education, study support and finally, the provision of financial assistance.

  12. Critical action research applied in clinical placement development in aged care facilities.

    PubMed

    Xiao, Lily D; Kelton, Moira; Paterson, Jan

    2012-12-01

    The aim of this study was to develop quality clinical placements in residential aged care facilities for undergraduate nursing students undertaking their nursing practicum topics. The proportion of people aged over 65 years is expected to increase steadily from 13% in 2006 to 26% of the total population in Australia in 2051. However, when demand is increasing for a nursing workforce competent in the care of older people, studies have shown that nursing students generally lack interest in working with older people. The lack of exposure of nursing students to quality clinical placements is one of the key factors contributing to this situation. Critical action research built on a partnership between an Australian university and five aged care organisations was utilised. A theoretical framework informed by Habermas' communicative action theory was utilised to guide the action research. Multiple research activities were used to support collaborative critical reflection and inform actions throughout the action research. Clinical placements in eight residential aged care facilities were developed to support 179 nursing students across three year-levels to complete their practicum topics. Findings were presented in three categories described as structures developed to govern clinical placement, learning and teaching in residential aged care facilities.

  13. Enhanced Impulsive Action Selection in Middle-Aged Adults—Insights From an Oculomotor Simon Task

    PubMed Central

    Duprez, Joan; Houvenaghel, Jean-François; Argaud, Soizic; Naudet, Florian; Dondaine, Thibaut; Auffret, Manon; Robert, Gabriel; Drapier, Dominique; Vérin, Marc; Sauleau, Paul

    2016-01-01

    Several studies have investigated the age-related impact in cognitive action control. However, to our knowledge, none of the studies have focused on the effect of moderate age on the strength of automatic activation according to the activation-suppression model. We therefore investigated the effect of moderate age on cognitive action control using an oculomotor version of the Simon task and distributional analyses. A group of middle-aged (n = 39; 57 ± 9 years) healthy adults were compared to a group of young healthy participants (n = 43; 24 ± 3 years). We first analyzed the overall impact of age on the congruence effect and then used conditional accuracy functions (CAFs) and delta plots to assess the strength of automatic activation and selective inhibition, respectively. Compared to young participants, middle-aged participants showed a greater congruence effect as well as higher rates of fast errors in conflict situations indicating an enhanced impulsive action selection. Furthermore, the overall downward slope of the congruence effect’s evolution was significantly steeper in older participants and the last slope tended to be significantly steeper. This may indicate that the middle-aged participants exerted a stronger selective inhibition. Our results suggest that middle-aged adults are more prone to impulsive action selection than young adults. Recent theories postulate that older adults might implement compensatory mechanisms to supply cognitive difficulties. This is in line with our results suggesting a potential greater selective inhibition. Overall, this study proposes that moderate aging impacts both processes of impulsive response selection and suppression underlying cognitive action control. PMID:27826239

  14. 5 CFR 890.908 - Notification of HHS.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... equivalent to the Medicare part B payment under the Medicare Participating Physician Fee Schedule. (c) A... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Limit on Inpatient Hospital Charges, Physician Charges, and FEHB Benefit Payments § 890.908 Notification of HHS. An FEHB plan, under the oversight of...

  15. 5 CFR 890.908 - Notification of HHS.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... equivalent to the Medicare part B payment under the Medicare Participating Physician Fee Schedule. (c) A... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Limit on Inpatient Hospital Charges, Physician Charges, and FEHB Benefit Payments § 890.908 Notification of HHS. An FEHB plan, under the oversight of...

  16. 5 CFR 890.908 - Notification of HHS.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... equivalent to the Medicare part B payment under the Medicare Participating Physician Fee Schedule. (c) A... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Limit on Inpatient Hospital Charges, Physician Charges, and FEHB Benefit Payments § 890.908 Notification of HHS. An FEHB plan, under the oversight of...

  17. 5 CFR 890.908 - Notification of HHS.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... equivalent to the Medicare part B payment under the Medicare Participating Physician Fee Schedule. (c) A... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Limit on Inpatient Hospital Charges, Physician Charges, and FEHB Benefit Payments § 890.908 Notification of HHS. An FEHB plan, under the oversight of...

  18. 5 CFR 890.908 - Notification of HHS.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... equivalent to the Medicare part B payment under the Medicare Participating Physician Fee Schedule. (c) A... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Limit on Inpatient Hospital Charges, Physician Charges, and FEHB Benefit Payments § 890.908 Notification of HHS. An FEHB plan, under the oversight of...

  19. 24 CFR 232.620 - Determination of compliance by HHS.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Determination of compliance by HHS. 232.620 Section 232.620 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT...

  20. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7...

  1. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7...

  2. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7...

  3. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7...

  4. 42 CFR 59a.7 - Other HHS regulations that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations that apply. 59a.7 Section 59a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.7...

  5. Age, sex, and pubertal phase influence mentalizing about emotions and actions in adolescents.

    PubMed

    Keulers, Esther H H; Evers, Elisabeth A T; Stiers, Peter; Jolles, Jelle

    2010-01-01

    This study examined (1) emotional versus cognitive developmental trajectories and (2) the influence of age-extrinsic factors (i.e., sex and puberty). Using a cross-sectional design, adolescents (N = 252) divided into four age-groups (ages 13, 15, 17, 19) performed two versions of a mentalizing task, about emotions and actions, as well as the Tower task. First, performance on all tasks improved linearly into late adolescence (age 19). Thus no differential trajectories were found for emotional versus cognitive development. Second, girls outperformed boys in mentalizing speed regarding both emotions and actions. In boys, a later pubertal phase was associated with increased mentalizing speed after controlling for age-group.

  6. 78 FR 48169 - Privacy Act of 1974; CMS Computer Match No. 2013-02; HHS Computer Match No. 1306; DoD-DMDC Match...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... Services Privacy Act of 1974; CMS Computer Match No. 2013-02; HHS Computer Match No. 1306; DoD-DMDC Match... Services (CMS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the... INFORMATION: The Computer Matching and Privacy Protection Act of 1988 (Public Law (Pub. L.) 100-503),...

  7. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  8. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  9. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false HHS criteria for requesting books, documents, and... Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and records. HHS will generally request books, documents, and records from a subcontractor only if...

  10. One Department Serving Rural America: HHS Rural Task Force Report to the Secretary.

    ERIC Educational Resources Information Center

    Department of Health and Human Services, Washington, DC.

    In 2001, the Department of Health and Human Services (HHS) created a rural task force to develop strategies to improve HHS services in rural communities. Fifteen HHS agencies have programs serving rural communities; child- and education-related programs provide child welfare services, Head Start, health promotion and prevention services, training…

  11. The Age Shift: Priorities for Action. Ageing Population Panel. Foresight: Making the Future Work for You.

    ERIC Educational Resources Information Center

    Department of Trade and Industry, London (England).

    The Foresight Ageing Population Panel, which included representatives of business, government, the science base, and other experts from the United Kingdom, was charged with examining trends in the United Kingdom's population and the other drivers of change that will operate in the next 20-30 years. The panel discussed the likely impacts of the…

  12. Age-related differences in task goal processing strategies during action cascading.

    PubMed

    Stock, Ann-Kathrin; Gohil, Krutika; Beste, Christian

    2016-06-01

    We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this question in a systems neurophysiological study using EEG and source localization in healthy older adults and employing mathematical constraints to determine the strategy applied. The results suggest that older adults seem to apply a less efficient strategy when cascading different actions. Compared to younger adults, older adults seem to struggle to hierarchically organize their actions, which leads to an inefficient and more parallel processing of different task goals. On a systems level, the observed deficit is most likely due to an altered processing of task goals at the response selection level (P3 ERP) and related to changes of neural processes in the temporo-parietal junction.

  13. The functional organization of preschool-age children's emotion expressions and actions in challenging situations.

    PubMed

    Dennis, Tracy A; Cole, Pamela M; Wiggins, Crystal N; Cohen, Laura H; Zalewski, Maureen

    2009-08-01

    Although functional links between emotion and action are implied in emotion regulation research, there is limited evidence that specific adaptive actions for coping with a challenge are more probable when certain negative emotions are expressed. The current study examined this question among 3- and 4-year-olds (N = 113; M age = 47.84 months, SD = 6.19). Emotion expressions and actions were observed during 2 challenging tasks: children waited for a gift while the mother worked, and children worked alone to retrieve a prize from a locked box with the wrong key. Angry and happy expressions, compared with sad expressions, were associated with more actions. These actions varied with the nature of the task, reflecting appreciation of situational appropriateness. In addition, when waiting with the mother, happiness was associated with the broadest range of actions, whereas when working alone on the locked box, anger was associated with the broadest range of actions. Results are discussed in terms of the adaptive function of negative emotions and in terms of functional and dimensional models of emotion. Findings have implications for the development of emotion regulation and social-emotional competence.

  14. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity to contest findings of research misconduct and administrative actions. (a) Opportunity to contest. A respondent may contest ORI findings of research misconduct and HHS administrative actions, including...

  15. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

    PubMed

    Bousquet, J; Bewick, M; Cano, A; Eklund, P; Fico, G; Goswami, N; Guldemond, N A; Henderson, D; Hinkema, M J; Liotta, G; Mair, A; Molloy, W; Monaco, A; Monsonis-Paya, I; Nizinska, A; Papadopoulos, H; Pavlickova, A; Pecorelli, S; Prados-Torres, A; Roller-Wirnsberger, R E; Somekh, D; Vera-Muñoz, C; Visser, F; Farrell, J; Malva, J; Andersen Ranberg, K; Camuzat, T; Carriazo, A M; Crooks, G; Gutter, Z; Iaccarino, G; Manuel de Keenoy, E; Moda, G; Rodriguez-Mañas, L; Vontetsianos, T; Abreu, C; Alonso, J; Alonso-Bouzon, C; Ankri, J; Arredondo, M T; Avolio, F; Bedbrook, A; Białoszewski, A Z; Blain, H; Bourret, R; Cabrera-Umpierrez, M F; Catala, A; O'Caoimh, R; Cesari, M; Chavannes, N H; Correia-da-Sousa, J; Dedeu, T; Ferrando, M; Ferri, M; Fokkens, W J; Garcia-Lizana, F; Guérin, O; Hellings, P W; Haahtela, T; Illario, M; Inzerilli, M C; Lodrup Carlsen, K C; Kardas, P; Keil, T; Maggio, M; Mendez-Zorrilla, A; Menditto, E; Mercier, J; Michel, J P; Murray, R; Nogues, M; O'Byrne-Maguire, I; Pappa, D; Parent, A S; Pastorino, M; Robalo-Cordeiro, C; Samolinski, B; Siciliano, P; Teixeira, A M; Tsartara, S I; Valiulis, A; Vandenplas, O; Vasankari, T; Vellas, B; Vollenbroek-Hutten, M; Wickman, M; Yorgancioglu, A; Zuberbier, T; Barbagallo, M; Canonica, G W; Klimek, L; Maggi, S; Aberer, W; Akdis, C; Adcock, I M; Agache, I; Albera, C; Alonso-Trujillo, F; Angel Guarcia, M; Annesi-Maesano, I; Apostolo, J; Arshad, S H; Attalin, V; Avignon, A; Bachert, C; Baroni, I; Bel, E; Benson, M; Bescos, C; Blasi, F; Barbara, C; Bergmann, K C; Bernard, P L; Bonini, S; Bousquet, P J; Branchini, B; Brightling, C E; Bruguière, V; Bunu, C; Bush, A; Caimmi, D P; Calderon, M A; Canovas, G; Cardona, V; Carlsen, K H; Cesario, A; Chkhartishvili, E; Chiron, R; Chivato, T; Chung, K F; d'Angelantonio, M; De Carlo, G; Cholley, D; Chorin, F; Combe, B; Compas, B; Costa, D J; Costa, E; Coste, O; Coupet, A-L; Crepaldi, G; Custovic, A; Dahl, R; Dahlen, S E; Demoly, P; Devillier, P; Didier, A; Dinh-Xuan, A T; Djukanovic, R; Dokic, D; Du Toit, G; Dubakiene, R; Dupeyron, A; Emuzyte, R; Fiocchi, A; Wagner, A; Fletcher, M; Fonseca, J; Fougère, B; Gamkrelidze, A; Garces, G; Garcia-Aymeric, J; Garcia-Zapirain, B; Gemicioğlu, B; Gouder, C; Hellquist-Dahl, B; Hermosilla-Gimeno, I; Héve, D; Holland, C; Humbert, M; Hyland, M; Johnston, S L; Just, J; Jutel, M; Kaidashev, I P; Khaitov, M; Kalayci, O; Kalyoncu, A F; Keijser, W; Kerstjens, H; Knezović, J; Kowalski, M; Koppelman, G H; Kotska, T; Kovac, M; Kull, I; Kuna, P; Kvedariene, V; Lepore, V; MacNee, W; Maggio, M; Magnan, A; Majer, I; Manning, P; Marcucci, M; Marti, T; Masoli, M; Melen, E; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot-Keurinck, J; Mlinarić, H; Momas, I; Montefort, S; Morais-Almeida, M; Moreno-Casbas, T; Mösges, R; Mullol, J; Nadif, R; Nalin, M; Navarro-Pardo, E; Nekam, K; Ninot, G; Paccard, D; Pais, S; Palummeri, E; Panzner, P; Papadopoulos, N K; Papanikolaou, C; Passalacqua, G; Pastor, E; Perrot, M; Plavec, D; Popov, T A; Postma, D S; Price, D; Raffort, N; Reuzeau, J C; Robine, J M; Rodenas, F; Robusto, F; Roche, N; Romano, A; Romano, V; Rosado-Pinto, J; Roubille, F; Ruiz, F; Ryan, D; Salcedo, T; Schmid-Grendelmeier, P; Schulz, H; Schunemann, H J; Serrano, E; Sheikh, A; Shields, M; Siafakas, N; Scichilone, N; Siciliano, P; Skrindo, I; Smit, H A; Sourdet, S; Sousa-Costa, E; Spranger, O; Sooronbaev, T; Sruk, V; Sterk, P J; Todo-Bom, A; Touchon, J; Tramontano, D; Triggiani, M; Tsartara, S I; Valero, A L; Valovirta, E; van Ganse, E; van Hage, M; van den Berge, M; Vandenplas, O; Ventura, M T; Vergara, I; Vezzani, G; Vidal, D; Viegi, G; Wagemann, M; Whalley, B; Wickman, M; Wilson, N; Yiallouros, P K; Žagar, M; Zaidi, A; Zidarn, M; Hoogerwerf, E J; Usero, J; Zuffada, R; Senn, A; de Oliveira-Alves, B

    2017-01-01

    The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

  16. [European innovation partnership on active and healthy aging: moving from policy to action].

    PubMed

    García Lizana, Francisca

    2013-01-01

    Demographic change and aging are a common challenge in Europe. The rising number of elderly people will need support at home, and will consume more healthcare services, putting further pressure on the welfare system. Collaborative, integrated and people-centered care provision, whether in hospitals, homes or in the community, is a way forward to sustainable and efficient care systems. Innovative treatments to address chronic diseases and the functional decline of older people will enable them to live longer in better health and with a better quality of life. To fully unleash the potential of aging in the European Union, the European Commission -within its Innovation Union policy- launched the first European Innovation Partnership on Active and Healthy Ageing (EIP AHA). Promoting engagement and partnerships among all stakeholders in the healthcare chain is essential. This article describes the theoretical foundations, the development and expectations of the initiative, and its first actions.

  17. Reasons, assessments and actions taken: sex and age differences in uses of Internet health information.

    PubMed

    Ybarra, Michele; Suman, Michael

    2008-06-01

    The Internet is transforming the way in which consumers approach their health care needs. Sex and age are influential aspects of one's health as well as disease risk and are thus integral components of the emerging picture of health information seekers. Using data from Surveying the Digital Future, Year 4, a nationally representative, longitudinal telephone survey of Americans 12 years of age and older (n = 2010), we examine the reasons for, assessments of and actions taken as a result of health information found online among men and women and older and younger people. Although we tend to think of the Internet as a young person's technology, the percent of adults 60 years of age and older is similar to that of adolescents using the Internet as a health care information resource, thus suggesting an untapped opportunity with online interventions for older adults. Nonetheless, as age increases so too does the report of frustration with the experience. Men are more likely to report a positive seeking experience than women. Differences in Internet use fail to explain these observed sex and age differences in the seeking experience. Across the spectrum of age, sex and Internet skill, Internet health information seeking appears to enhance the patient-provider relationship.

  18. The HHS-HCC Risk Adjustment Model for Individual and Small Group Markets under the Affordable Care Act

    PubMed Central

    Kautter, John; Pope, Gregory C; Ingber, Melvin; Freeman, Sara; Patterson, Lindsey; Cohen, Michael; Keenan, Patricia

    2014-01-01

    Beginning in 2014, individuals and small businesses are able to purchase private health insurance through competitive Marketplaces. The Affordable Care Act (ACA) provides for a program of risk adjustment in the individual and small group markets in 2014 as Marketplaces are implemented and new market reforms take effect. The purpose of risk adjustment is to lessen or eliminate the influence of risk selection on the premiums that plans charge. The risk adjustment methodology includes the risk adjustment model and the risk transfer formula. This article is the second of three in this issue of the Review that describe the Department of Health and Human Services (HHS) risk adjustment methodology and focuses on the risk adjustment model. In our first companion article, we discuss the key issues and choices in developing the methodology. In this article, we present the risk adjustment model, which is named the HHS-Hierarchical Condition Categories (HHS-HCC) risk adjustment model. We first summarize the HHS-HCC diagnostic classification, which is the key element of the risk adjustment model. Then the data and methods, results, and evaluation of the risk adjustment model are presented. Fifteen separate models are developed. For each age group (adult, child, and infant), a model is developed for each cost sharing level (platinum, gold, silver, and bronze metal levels, as well as catastrophic plans). Evaluation of the risk adjustment models shows good predictive accuracy, both for individuals and for groups. Lastly, this article provides examples of how the model output is used to calculate risk scores, which are an input into the risk transfer formula. Our third companion paper describes the risk transfer formula. PMID:25360387

  19. Study on Interactions between the Major Apple Valsa Canker Pathogen Valsa mali and Its Biocontrol Agent Saccharothrix yanglingensis Hhs.015 Using RT-qPCR

    PubMed Central

    Fan, Dongying; Li, Yanfang; Zhao, Lingyun; Li, Zhengpeng; Huang, Lili; Yan, Xia

    2016-01-01

    The mechanism of biocontrol agent Saccharothrix yanglingensis Hhs.015 action against Valsa mali, a major apple Valsa canker pathogen, was examined using a novel, sensitive (minimum detection limit 100 pg/μL) and reliably RT-qPCR technique. Prior to lesion formation, total concentration of V. mali in the bark showed a significant decrease (p<0.05) after 24 h of Hhs.015 treatment. This was more pronounced at 48 and 96 h post treatment. After lesion formation, levels of V. mali remained constant at the boundary between infected and uninfected bark tissues, although the relative expansion rate of the lesion was significantly reduced (p<0.05). Gene expression levels of endo-polygalacturonase, a marker for fungal pathogenicity, were sharply reduced while host induced resistance callose synthase levels increased significantly (p<0.05) at the boundary bark at 9 d after Hhs.015 treatment. The results showed that biocontrol agent Hhs.015 prevented infection of V. mali by inhibiting pathogen growth, down-regulating pathogenicity factor expression and inducing a high level of host resistance. PMID:27611855

  20. [Urgent action needed to raise public awareness of age-related macular degeneration in China].

    PubMed

    Chen, You-xin

    2009-05-01

    Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The impact of AMD to the economics, society and the patients are huge. However, the awareness of AMD is alarmingly low. Even in developed countries, the awareness of AMD is below 30%. In terms of the risk factors of AMD, the awareness is also quite low, e.g., only 32% were aware of the causal link between smoking and AMD. Although cataract is the leading cause of the blindness in China, as the economic and social progress, as the coming of the aging society, as people pursuing higher quality of life, AMD will become a unignoring public health problem. Thus, it is urgent to take action now to increase the public awareness of AMD.

  1. U.S. Perspectives: International Action on Aging. A Background Paper Prepared by the American Association for International Aging for the Select Committee on Aging. House of Representatives, Ninety-Eighth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    In response to challenges and guidelines set forth in the 1982 International Plan of Action on Aging (IPAA) by the World Assembly on Aging, this background paper summarizes (1) immediate and long-range reasons for the World Assembly; (2) content and significance of the IPAA and the factual base on which action plan decisions were made; (3)…

  2. 48 CFR 353.370-674 - Form HHS 674, Structured Approach Profit/Fee Objective.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Form HHS 674, Structured Approach Profit/Fee Objective. 353.370-674 Section 353.370-674 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CLAUSES AND FORMS FORMS Illustrations of Forms 353.370-674 Form HHS...

  3. 48 CFR 353.370-674 - Form HHS 674, Structured Approach Profit/Fee Objective.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Form HHS 674, Structured Approach Profit/Fee Objective. 353.370-674 Section 353.370-674 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CLAUSES AND FORMS FORMS Illustrations of Forms 353.370-674 Form HHS...

  4. 48 CFR 353.370-674 - Form HHS 674, Structured Approach Profit/Fee Objective.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Form HHS 674, Structured Approach Profit/Fee Objective. 353.370-674 Section 353.370-674 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CLAUSES AND FORMS FORMS Illustrations of Forms 353.370-674 Form HHS...

  5. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false FAC-C and HHS SAC... Responsibilities 301.603-72 FAC-C and HHS SAC certification requirements. (a) The FAC-C certification program is... thereunder are not required to re-take training courses, but shall follow FAC-C training requirements...

  6. 45 CFR 158.607 - Factors HHS uses to determine the amount of penalty.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... level of financial and other impacts on affected individuals. (3) Other factors as justice may require. ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Factors HHS uses to determine the amount of... Civil Penalties § 158.607 Factors HHS uses to determine the amount of penalty. In determining the...

  7. 75 FR 45628 - Delayed Update of the HHS Poverty Guidelines for the Remainder of 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... HUMAN SERVICES Office of the Secretary Delayed Update of the HHS Poverty Guidelines for the Remainder of... delayed update of the Department of Health and Human Services (HHS) poverty guidelines for the remainder of 2010, and until the 2011 poverty guidelines are published, which is expected to occur in...

  8. 75 FR 3734 - 2009 HHS Poverty Guidelines Extended Until March 1, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... HUMAN SERVICES Office of the Secretary 2009 HHS Poverty Guidelines Extended Until March 1, 2010 AGENCY... Human Services (HHS) poverty guidelines will remain in effect until updated 2010 poverty guidelines are... Federal, State, or local office that is responsible for that program. For information about...

  9. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...—Responsibility of applicants for promoting objectively in research for which PHS funding is sought 45 CFR part 16... FOR RESEARCH PROJECTS § 52.8 Other HHS regulations and policies that apply. Several other HHS policies... and suspension (nonprocurement) and governmentwide requirements for drug-free workplace (grants)...

  10. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...—Responsibility of applicants for promoting objectively in research for which PHS funding is sought 45 CFR part 16... FOR RESEARCH PROJECTS § 52.8 Other HHS regulations and policies that apply. Several other HHS policies... and suspension (nonprocurement) and governmentwide requirements for drug-free workplace (grants)...

  11. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...—Responsibility of applicants for promoting objectively in research for which PHS funding is sought 45 CFR part 16... FOR RESEARCH PROJECTS § 52.8 Other HHS regulations and policies that apply. Several other HHS policies... and suspension (nonprocurement) and governmentwide requirements for drug-free workplace (grants)...

  12. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...—Responsibility of applicants for promoting objectively in research for which PHS funding is sought 45 CFR part 16... FOR RESEARCH PROJECTS § 52.8 Other HHS regulations and policies that apply. Several other HHS policies... and suspension (nonprocurement) and governmentwide requirements for drug-free workplace (grants)...

  13. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...—Responsibility of applicants for promoting objectively in research for which PHS funding is sought 45 CFR part 16... FOR RESEARCH PROJECTS § 52.8 Other HHS regulations and policies that apply. Several other HHS policies... and suspension (nonprocurement) and governmentwide requirements for drug-free workplace (grants)...

  14. 42 CFR 420.303 - HHS criteria for requesting books, documents, and records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false HHS criteria for requesting books, documents, and... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PROGRAM INTEGRITY: MEDICARE Access to Books, Documents, and Records of Subcontractors § 420.303 HHS criteria for requesting books, documents, and...

  15. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or toxins must be immediately reported by telephone, facsimile, or e-mail: Botulinum neurotoxins... 42 Public Health 1 2012-10-01 2012-10-01 false Exemptions for HHS select agents and toxins. 73.5..., INSPECTION, LICENSING SELECT AGENTS AND TOXINS § 73.5 Exemptions for HHS select agents and toxins....

  16. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.10 Other HHS regulations and policies that apply....

  17. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.10 Other HHS regulations and policies that apply....

  18. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.10 Other HHS regulations and policies that apply....

  19. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.10 Other HHS regulations and policies that apply....

  20. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.10 Other HHS regulations and policies that apply....

  1. 48 CFR 311.7001 - Section 508 accessibility standards for HHS Web site content and communications materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... standards for HHS Web site content and communications materials. 311.7001 Section 311.7001 Federal... that is specifically intended for publication on, or delivery via, an HHS-owned or -funded Web site. (b... publication on, or delivery via, an HHS-owned or -funded Web site, the Project Officer shall consult with...

  2. 48 CFR 311.7001 - Section 508 accessibility standards for HHS Web site content and communications materials.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... standards for HHS Web site content and communications materials. 311.7001 Section 311.7001 Federal... that is specifically intended for publication on, or delivery via, an HHS-owned or -funded Web site. (b... publication on, or delivery via, an HHS-owned or -funded Web site, the Project Officer shall consult with...

  3. 48 CFR 311.7001 - Section 508 accessibility standards for HHS Web site content and communications materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... standards for HHS Web site content and communications materials. 311.7001 Section 311.7001 Federal... that is specifically intended for publication on, or delivery via, an HHS-owned or -funded Web site. (b... publication on, or delivery via, an HHS-owned or -funded Web site, the Project Officer shall consult with...

  4. 48 CFR 311.7001 - Section 508 accessibility standards for HHS Web site content and communications materials.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... standards for HHS Web site content and communications materials. 311.7001 Section 311.7001 Federal... that is specifically intended for publication on, or delivery via, an HHS-owned or -funded Web site. (b... publication on, or delivery via, an HHS-owned or -funded Web site, the Project Officer shall consult with...

  5. 48 CFR 311.7001 - Section 508 accessibility standards for HHS Web site content and communications materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... standards for HHS Web site content and communications materials. 311.7001 Section 311.7001 Federal... that is specifically intended for publication on, or delivery via, an HHS-owned or -funded Web site. (b... publication on, or delivery via, an HHS-owned or -funded Web site, the Project Officer shall consult with...

  6. 78 FR 32255 - HHS-Operated Risk Adjustment Data Validation Stakeholder Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... information that we obtain through this meeting may aid future policy-making for the HHS-operated risk... knives), and dogs or other animals (except service animals). Once cleared for entry to the...

  7. 45 CFR 74.12 - Forms for applying for HHS financial assistance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Single Point of Contact (SPOC). The name and address of the SPOC for a particular State can be obtained from the HHS awarding agency or the Catalog of Federal Domestic Assistance. The SPOC shall advise...

  8. Naturalistic Action Performance Distinguishes Amnestic Mild Cognitive Impairment from Healthy Aging.

    PubMed

    Gold, David A; Park, Norman W; Murphy, Kelly J; Troyer, Angela K

    2015-07-01

    Individuals with amnestic mild cognitive impairment (aMCI) show minor decrements in their instrumental activities of daily living (IADL). Sensitive measures of IADL performance are needed to capture the mild difficulties observed in aMCI groups. Routine naturalistic actions (NAs) are familiar IADL-type activities that require individuals to enact everyday tasks such as preparing coffee. In the current study we examined the extent to which NAs could be used to help facilitate differential diagnosis of aMCI relative to composite measures of episodic memory, semantic knowledge, and executive function. Healthy older adults (n=24) and individuals with aMCI (n=24) enacted two highly familiar NAs and completed tests of episodic memory, semantic knowledge, and executive function. Binary logistic regression was used to predict group membership (aMCI vs. control participants). The regression analyses indicated that NA performance could reliably predict group membership, over and above measures of cognitive functioning. These findings indicated that NA performance can be used to help facilitate differential diagnosis of healthy aging and aMCI and used as an outcome measure in intervention studies.

  9. Pharmacokinetics and acute lipolytic actions of growth hormone. Impact of age, body composition, binding proteins, and other hormones.

    PubMed

    Hansen, Troels Krarup

    2002-10-01

    The biologic actions of endogeneous growth hormone (GH) depend on its secretion and clearance rates as well as sensitivity at the receptor level. Aberrations in GH pharmacokinetics and pharmacodynamics may occur with increasing age, and have been implicated in diseases such as obesity, diabetes mellitus, and critical illness. In this review, recent insights into the association between GH metabolism and age, body composition, binding proteins and other hormones are discussed.

  10. Thermoclastic and cryoclastic action on calcareous building stone: durability to artificial ageing

    NASA Astrophysics Data System (ADS)

    Germinario, Luigi; Andriani, Gioacchino Francesco; Laviano, Rocco

    2014-05-01

    were petrographically characterized through optical microscopy on thin section, followed by a geotechnical parameterization with petrophysical measurements (dry density, total porosity, MIP porosity) and indirect ultrasonic and sclerometric tests. Then, after every 20 ageing cycles, the same tests stated above were carried out; in addition, the measurement of residual strains and SEM observations were performed. With this methodology, the gradual modifications in fabric, petrophysical and mechanical properties of the tested stone were analyzed. The results revealed a high durability of the material to the conditions of ageing experimented. The main modifications of the samples concerned fabric, i.e. microcracking due to thermoclastic and cryoclastic action, which occurred only in limited areas for an uneven distribution of internal stresses. For this reason, no evident effects on the macroscopic integrity and physico-mechanical performance were noted, whereas the stone almost preserved the original strength and elasticity. Finally, the data gathered were used to suggest a method for the evaluation of the vulnerability of "pietra gentile" to freeze-thaw microcracking, based on the peculiar porosimetric distribution and the environmental conditions of weathering. New information are globally provided about a stone material that has been largely used in the Apulian monumental heritage, but has received scarce attention from the archaeometric research so far.

  11. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

    PubMed

    Stout, Michael B; Tchkonia, Tamara; Pirtskhalava, Tamar; Palmer, Allyson K; List, Edward O; Berryman, Darlene E; Lubbers, Ellen R; Escande, Carlos; Spong, Adam; Masternak, Michal M; Oberg, Ann L; LeBrasseur, Nathan K; Miller, Richard A; Kopchick, John J; Bartke, Andrzej; Kirkland, James L

    2014-07-01

    The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced age-related lipid redistribution. Primary preadipocytes from GH-resistant mice also were found to have greater differentiation capacity at 20 months of age when compared to controls. GH activity was also found to be positively associated with senescent cell accumulation in WAT. Our results demonstrate an association between GH activity, age-related WAT dysfunction, and WAT senescent cell accumulation in mice. Further studies are needed to determine if GH is directly inducing cellular senescence in WAT or if GH actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible.

  12. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

    PubMed Central

    Pirtskhalava, Tamar; Palmer, Allyson K.; List, Edward O.; Berryman, Darlene E.; Lubbers, Ellen R.; Escande, Carlos; Spong, Adam; Masternak, Michal M.; Oberg, Ann L.; LeBrasseur, Nathan K.; Miller, Richard A.; Kopchick, John J.; Bartke, Andrzej; Kirkland, James L.

    2014-01-01

    The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced age-related lipid redistribution. Primary preadipocytes from GH-resistant mice also were found to have greater differentiation capacity at 20 months of age when compared to controls. GH activity was also found to be positively associated with senescent cell accumulation in WAT. Our results demonstrate an association between GH activity, age-related WAT dysfunction, and WAT senescent cell accumulation in mice. Further studies are needed to determine if GH is directly inducing cellular senescence in WAT or if GH actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible. PMID:25063774

  13. "What If? As If", An Approach to Action Research Practice: Becoming-Different in School-Age Childcare

    ERIC Educational Resources Information Center

    Kane, Eva

    2015-01-01

    When doing research, or for that matter working in school-age childcare, the researcher/teacher is required to develop a plan for her/his work in spite of knowing that unexpected things will happen. This article aims to explore the relationship between the process of planning and unexpected events in childcare practice and action research. The…

  14. Examining predictors of physical activity among inactive middle-aged women: an application of the health action process approach.

    PubMed

    Barg, Carolyn J; Latimer, Amy E; Pomery, Elizabeth A; Rivers, Susan E; Rench, Tara A; Prapavessis, Harry; Salovey, Peter

    2012-01-01

    This study tested several relationships predicted by the Health Action Process Approach (HAPA) in a sample of 175 generally healthy, inactive, middle-aged women (40-65 yrs old) over a 12 week period. Participants' physical activity, risk perceptions, outcome expectancies, action self-efficacy and intention were measured at baseline. Planning and maintenance self-efficacy were measured 4 weeks later. Physical activity behaviour was measured 12 weeks after baseline. The HAPA relationships were examined using a structural equation model. The data fit the model well and revealed several significant relationships. Action self-efficacy was the best predictor of intention. Maintenance self-efficacy was the best predictor of planning and behaviour. Contrary to the tenets of HAPA and to past research, planning did not predict behaviour. Overall, HAPA provides a useful framework for identifying determinants of physical activity intentions and behaviour within a group of inactive, middle-aged women.

  15. Effects of age and muscle action type on acute strength and power recovery following fatigue of the leg flexors.

    PubMed

    Thompson, Brennan J; Conchola, Eric C; Stock, Matt S

    2015-12-01

    Short-term strength and power recovery patterns following fatigue have received little research attention, particularly as they pertain to age-specific responses, and the leg flexors (i.e., hamstrings) muscle group. Thus, research is warranted addressing these issues because both age-related alterations in the neuromuscular system and mode of muscle action (e.g., eccentric, concentric, isometric) may differentially influence recovery responses from fatigue. The aim of this study was to investigate the strength and power recovery responses for eccentric, concentric, and isometric muscle actions of the leg flexors in young and older men following an isometric, intermittent fatigue-inducing protocol. Nineteen young (age = 25 ± 3 years) and nineteen older (71 ± 4) men performed maximal voluntary contractions (MVCs) for eccentric, concentric, and isometric muscle actions followed by a fatigue protocol of intermittent (0.6 duty cycle) isometric contractions of the leg flexors at 60% of isometric MVC. MVCs of each muscle action were performed at 0, 7, 15, and 30 min following fatigue. Peak torque (PT) and mean power values were calculated from the MVCs and the eccentric/concentric ratio (ECR) was derived. For PT and mean power, young men showed incomplete recovery at all time phases, whereas the older men had recovered by 7 min. Eccentric and isometric muscle actions showed incomplete recovery at all time phases, but concentric recovered by 7 min, independent of age. The ECR was depressed for up to 30 min following fatigue. More rapid and pronounced recovery in older men and concentric contractions may be related to physiological differences specific to aging and muscle action motor unit patterns. Individuals and clinicians may use these time course responses as a guide for recovery following activity-induced fatigue.

  16. Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications.

    PubMed

    Nagai, Ryoji; Murray, David B; Metz, Thomas O; Baynes, John W

    2012-03-01

    This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed oxidation reactions that catalyze AGE formation. We then present evidence that chelation is the most likely mechanism by which ACE inhibitors, angiotensin receptor blockers, and aldose reductase inhibitors inhibit AGE formation in diabetes. Finally, we note several recent studies demonstrating therapeutic benefits of chelators for diabetic cardiovascular and renal disease. We conclude that chronic, low-dose chelation therapy deserves serious consideration as a clinical tool for prevention and treatment of diabetes complications.

  17. Clinical outcomes and mechanism of action for rheopheresis treatment of age-related macular degeneration (AMD).

    PubMed

    Pulido, Jose; Sanders, Donald; Winters, Jeffrey L; Klingel, Reinhard

    2005-10-01

    The primary goals are to provide a comprehensive explanation of the potential role of therapeutic apheresis in the treatment of Age-Related Macular Degeneration (AMD). Initial clinical results with this technique and a summary of current literature that addresses the mechanism of action for the Rheopheresis approach are presented. Rheopheresis has been found to be a safe and effective application of double filtration plasmapheresis (DFPP) for extracorporeal hemorheotherapy. In this report, it is proposed that Rheopheresis results in an immediate decrease in the proportion of high molecular weight proteins that could combine with the TIMP-3 fibulin complex allowing for the barely functioning retinal pigment epithelial (RPE) cells to function better and diminish the release of vascular endothelial growth factor (VEGF). Interim results from the randomized, double-masked MIRA-1 clinical trial include (1) improved vision restoration; 28.0% of Treated Primary Eyes increased by > or = 2 lines of best corrected visual acuity (BCVA) compared to 18.2% of Placebo Eyes; (2) a decline in progressive vision loss; 0.0% of treated eyes progressing to worse than 20/200 vision over the 12-month study compared to 18.2% of Placebo Eyes; (3) 57.9% of Treatment Eyes obtained improvement in their BCVA to 20/40 or better (driver's license qualification), compared to only 14.3% of Placebo Eyes 12-month post-treatment. Rheopheresis treatment shows strong promise as a viable clinical option for patients suffering from the dry form of AMD in terms of minimizing vision loss, vision restoration, and overall quality of life factors. Expanded clinical outcomes from the ongoing MIRA-1 clinical study will be valuable in the assessment of this new clinical tool for ophthalmic applications.

  18. 75 FR 61766 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ..., Aging Research, National Institutes of Health, HHS) Dated: September 30, 2010. Jennifer S. Spaeth... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Cartilage Aging and Osteoarthritis....

  19. World Assembly on Aging First Global Focus on Action and Strategies for the Future.

    ERIC Educational Resources Information Center

    Francis, Sybil E.

    1985-01-01

    The author interprets the diversity of humanitarian and development issues behind "the age of aging" as highlighted by the United Nations World Assembly on Aging. She examines education as a basic human right of the elderly, continuous adult education, access to education and culture, and funding for these programs. (CT)

  20. Ten commandments for the future of ageing research in the UK: a vision for action

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Increases in longevity resulting from improvements in health care and living conditions together with a decrease in fertility rates have contributed to a shift towards an aged population profile. For the first time the UK has more people over age 60 than below 16 years of age. The increase in longev...

  1. Age and hypertrophy related changes in contractile post-rest behavior and action potential properties in isolated rat myocytes

    PubMed Central

    Nguyen, Quan; Schuettel, Manuela; Thomas, Daniel; Dreiner, Ulrike; Grohé, Christian; Meyer, Rainer

    2007-01-01

    “Physiological” aging as well as early and progressive cardiac hypertrophy may affect action potential (AP) pattern, contractile function, and Ca2+ handling. We hypothesize that contractile function is disturbed in hypertrophy from early stages and is differently affected in aged myocardium. In vivo function, cardiomyocyte contractile behavior and APs were compared in Wistar-Kyoto (WIS) rats and spontaneously hypertensive rats (SHR) at different ages and degrees of hypertrophy (3–4, 9–11, 20–24 months). Post-rest (PR) behavior was used to investigate the relative contribution of the sarcoplasmic reticulum (SR) and the Na/Ca exchanger (NCX) to cytosolic Ca2+ removal. APs were recorded by whole-cell current-clamp and sarcomere shortening by video microscopy. Cyclopiazonic acid was used to suppress Ca2+ ATPase (SERCA) function. Heart weight/body weight ratio was increased in SHR versus WIS within all age groups. Myocyte steady state (SS) shortening amplitude was reduced in young SHR versus WIS. Aging led to a significant decay of SS contractile amplitude and relengthening velocity in WIS, but the PR potentiation was maintained. In contrast, aging in SHR led to a decrease of PR potentiation, while SS contraction and relengthening velocity increased. APD50% was always prolonged in SHR versus WIS. With aging, APD50% increased in both WIS and SHR, but was still shorter in WIS. However, in old WIS the late AP portion (APD90%) was prolonged. Ca2+ handling and AP properties are disturbed progressively with aging and with increasing hypertrophy. Decreased amplitude of shortening and velocity of relengthening in aged WIS may be attributed to reduced SERCA function. In SHR, an increase in SR leak and shift towards transmembraneous Ca handling via NCX may be responsible for the changes in contractile function. A prolonged APD90% in aged WIS may be an adaptive mechanism to preserve basal contractility. Therefore, the effects on contractile parameters and AP are

  2. Protective actions of melatonin and growth hormone on the aged cardiovascular system.

    PubMed

    Paredes, Sergio D; Forman, Katherine A; García, Cruz; Vara, Elena; Escames, Germaine; Tresguerres, Jesús A F

    2014-05-01

    Epidemiological studies indicate that certain aspects of lifestyle and genetics act as risk factors for a variety of cardiovascular disorders, including coronary disease, hypertension, heart failure and stroke. Aging, however, appears to be the major contributor for morbidity and mortality of the impaired cardiovascular system. Growth hormone (GH) and melatonin seem to prevent cardiac aging, as they contribute to the recovery of several physiological parameters affected by age. These hormones exhibit antioxidant properties and decrease oxidative stress and apoptosis. This paper summarizes a set of studies related to the potential role that therapy with GH and melatonin may play in the protection of the altered cardiac function due to aging, with a focus on experiments performed in our laboratory using the senescence-accelerated mouse as an aging model. In general, we observed significantly increased inflammation, oxidative stress and apoptosis markers in hearts from senescence-accelerated prone 10-month-old animals compared to 2-month-old controls, while anti-inflammatory and antiapoptotic markers as well as endothelial nitric oxide synthase were decreased. Senescence-accelerated resistant animals showed no significant changes with age. GH or melatonin treatment prevented the age-dependent cardiac alterations observed in the senescence-accelerated prone group. Combined administration of GH plus melatonin reduced the age-related changes in senescence-accelerated prone hearts in an additive fashion that was different to that displayed when administered alone. GH and melatonin may be potential agents for counteracting oxidative stress, apoptosis and inflammation in the aging heart.

  3. Green Team Recognized with HHS Green Champion Award Honorable Mention | Poster

    Cancer.gov

    Courtesy of the NCI at Frederick Green Team The NCI at Frederick Green Team received a Department of Health and Human Services (HHS) Green Champion Award honorable mention in June for the team’s plant swap initiative, begun in October 2012.  “The Green Team has been doing a great job this past year, and it is wonderful that their efforts have been recognized by the HHS through the Green Champion Awards,” said Craig Reynolds, Ph.D., director of the NCI Office of Scientific Operations (OSO). 

  4. Teacher Preparation and Certification in Aging: From Benign Neglect to Needed Actions.

    ERIC Educational Resources Information Center

    Myers, Jane E.; Burdin, Joel L.

    1988-01-01

    Negative attitudes of children toward older persons are well documented, as is influence of teachers on children's attitudes. Surveyed state departments of education to determine curriculum content related to adult development and aging in teacher preparation standards. Few states required preparation in adult development and aging for teacher…

  5. Teachers for the Global Age: A Call to Action for Funders

    ERIC Educational Resources Information Center

    Devlin-Foltz, Betsy

    2010-01-01

    This postscript commentary challenges private and public funders to take action in support of the internationalization of teacher preparation programs by funding efforts for much needed resources, in order to prepare twenty-first-century teachers to teach with global perspectives. Specific ideas for foundations, corporate philanthropy, and…

  6. In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

    PubMed

    Cassese, Angela; Esposito, Iolanda; Fiory, Francesca; Barbagallo, Alessia P M; Paturzo, Flora; Mirra, Paola; Ulianich, Luca; Giacco, Ferdinando; Iadicicco, Claudia; Lombardi, Angela; Oriente, Francesco; Van Obberghen, Emmanuel; Beguinot, Francesco; Formisano, Pietro; Miele, Claudia

    2008-12-26

    Chronic hyperglycemia promotes insulin resistance at least in part by increasing the formation of advanced glycation end products (AGEs). We have previously shown that in L6 myotubes human glycated albumin (HGA) induces insulin resistance by activating protein kinase Calpha (PKCalpha). Here we show that HGA-induced PKCalpha activation is mediated by Src. Coprecipitation experiments showed that Src interacts with both the receptor for AGE (RAGE) and PKCalpha in HGA-treated L6 cells. A direct interaction of PKCalpha with Src and insulin receptor substrate-1 (IRS-1) has also been detected. In addition, silencing of IRS-1 expression abolished HGA-induced RAGE-PKCalpha co-precipitation. AGEs were able to induce insulin resistance also in vivo, as insulin tolerance tests revealed a significant impairment of insulin sensitivity in C57/BL6 mice fed a high AGEs diet (HAD). In tibialis muscle of HAD-fed mice, insulin-induced glucose uptake and protein kinase B phosphorylation were reduced. This was paralleled by a 2.5-fold increase in PKCalpha activity. Similarly to in vitro observations, Src phosphorylation was increased in tibialis muscle of HAD-fed mice, and co-precipitation experiments showed that Src interacts with both RAGE and PKCalpha. These results indicate that AGEs impairment of insulin action in the muscle might be mediated by the formation of a multimolecular complex including RAGE/IRS-1/Src and PKCalpha.

  7. Preventing and managing herpes zoster: key actions to foster healthy aging.

    PubMed

    Maggi, Stefania; Gabutti, Giovanni; Franco, Elisabetta; Bonanni, Paolo; Conversano, Michele; Ferro, Antonio; Lazzari, Marzia; Rossi, Alessandro; Scotti, Silvestro; Vitale, Francesco; Volpi, Antonio; Greco, Donato

    2015-02-01

    Population aging is the demographic phenomenon characterizing all countries in the world, and it is challenging the national infrastructures, in particular health systems. However, aging itself is not associated with increased medical spending, but disability and comorbidity that affect older individuals are the actual drivers for health expenditures. Therefore, if people age in better health, medical spending may be significantly reduced. Preventative interventions proved to be effective in reducing/preventing disease and disability and often found to be cost effective, include diet and exercise interventions, medications, routine disease screenings, and immunizations. Vaccination can protect older citizens against life-threatening diseases, such as influenza, pneumococcal infections, tetanus, and against diseases which adversely impact their quality of life, such as herpes zoster (HZ). Including HZ vaccination in its citizens' lifetime immunization calendar can reinforce Europe's commitment toward active, healthy aging. This paper outlines the consensus statement of a group of Italian experts on HZ.

  8. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations..., Contracting Authority, and Responsibilities 301.603-74 Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C certification, all warranted Contracting Officers, regardless of series,...

  9. 42 CFR 52e.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations and policies that apply. 52e.8 Section 52e.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.8 Other...

  10. 42 CFR 52e.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations and policies that apply. 52e.8 Section 52e.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.8 Other...

  11. 42 CFR 52e.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations and policies that apply. 52e.8 Section 52e.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.8 Other...

  12. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other HHS select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days...

  13. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other HHS select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days...

  14. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Which other HHS regulations apply to these awards? 51d.8 Section 51d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other...

  15. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Which other HHS regulations apply to these awards? 51d.8 Section 51d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other...

  16. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Which other HHS regulations apply to these awards? 51d.8 Section 51d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other...

  17. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Which other HHS regulations apply to these awards? 51d.8 Section 51d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other...

  18. 42 CFR 51d.8 - Which other HHS regulations apply to these awards?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Which other HHS regulations apply to these awards? 51d.8 Section 51d.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MENTAL HEALTH AND SUBSTANCE ABUSE EMERGENCY RESPONSE PROCEDURES § 51d.8 Which other...

  19. 42 CFR 59.10 - What other HHS regulations apply to grants under this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What other HHS regulations apply to grants under this subpart? 59.10 Section 59.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services §...

  20. 42 CFR 59.10 - What other HHS regulations apply to grants under this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What other HHS regulations apply to grants under this subpart? 59.10 Section 59.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services §...

  1. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant applications and research and development contract projects 45 CFR part 16—Procedures of the Departmental Grant... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  2. 42 CFR 66.207 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.207 Other HHS... procedure 42 CFR part 50, subpart F—Responsibility of applicants for promoting objectivity in research for which PHS funding is sought. 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  3. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant applications and research and development contract projects 45 CFR part 16—Procedures of the Departmental Grant... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  4. 42 CFR 66.207 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.207 Other HHS... procedure 42 CFR part 50, subpart F—Responsibility of applicants for promoting objectivity in research for which PHS funding is sought. 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  5. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant applications and research and development contract projects 45 CFR part 16—Procedures of the Departmental Grant... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  6. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant applications and research and development contract projects 45 CFR part 16—Procedures of the Departmental Grant... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  7. 42 CFR 66.207 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.207 Other HHS... procedure 42 CFR part 50, subpart F—Responsibility of applicants for promoting objectivity in research for which PHS funding is sought. 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  8. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant applications and research and development contract projects 45 CFR part 16—Procedures of the Departmental Grant... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  9. 42 CFR 66.207 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.207 Other HHS... procedure 42 CFR part 50, subpart F—Responsibility of applicants for promoting objectivity in research for which PHS funding is sought. 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  10. 42 CFR 66.207 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.207 Other HHS... procedure 42 CFR part 50, subpart F—Responsibility of applicants for promoting objectivity in research for which PHS funding is sought. 45 CFR part 16—Procedures of the Departmental Grant Appeals Board 45...

  11. 76 FR 20568 - HHS Plan for Retrospective Review Under Executive Order 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ...: Oliver Potts at (202) 690-6392. SUPPLEMENTARY INFORMATION: On January 18, 2011, President Obama issued.... HHS' responsibilities include: Medicare, Medicaid, increasing access to care and insurance coverage... every five years of regulations establishing relative value units for health care provider...

  12. 42 CFR 63a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations and policies that apply. 63a.11 Section 63a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.11 Other...

  13. 42 CFR 63a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations and policies that apply. 63a.11 Section 63a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.11 Other...

  14. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 66.112 Section 66.112 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.112 Other...

  15. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations and policies that apply. 66.112 Section 66.112 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.112 Other...

  16. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Other HHS regulations and policies that apply. 66.112 Section 66.112 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.112 Other...

  17. 42 CFR 63a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations and policies that apply. 63a.11 Section 63a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.11 Other...

  18. 42 CFR 63a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Other HHS regulations and policies that apply. 63a.11 Section 63a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.11 Other...

  19. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations and policies that apply. 66.112 Section 66.112 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.112 Other...

  20. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Other HHS regulations and policies that apply. 66.112 Section 66.112 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.112 Other...

  1. 42 CFR 63a.11 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 63a.11 Section 63a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.11 Other...

  2. 42 CFR 52e.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Other HHS regulations and policies that apply. 52e.8 Section 52e.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.8 Other...

  3. 42 CFR 52e.8 - Other HHS regulations and policies that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 52e.8 Section 52e.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.8 Other...

  4. More than meets the eye: age differences in the capture and suppression of oculomotor action.

    PubMed

    Ridderinkhof, K Richard; Wijnen, Jasper G

    2011-01-01

    Salient visual stimuli capture attention and trigger an eye-movement toward its location reflexively, regardless of an observer's intentions. Here we aim to investigate the effect of aging (1) on the extent to which salient yet task-irrelevant stimuli capture saccades, and (2) on the ability to selectively suppress such oculomotor responses. Young and older adults were asked to direct their eyes to a target appearing in a stimulus array. Analysis of overall performance shows that saccades to the target object were disrupted by the appearance of a task-irrelevant abrupt-onset distractor when the location of this distractor did not coincide with that of the target object. Conditional capture function analyses revealed that, compared to young adults, older adults were more susceptible to oculomotor capture, and exhibited deficient selective suppression of the responses captured by task-irrelevant distractors. These effects were uncorrelated, suggesting two independent sources off age-related decline. Thus, with advancing age, salient visual distractors become more distracting; in part because they trigger reflexive eye-movements more potently; in part because of failing top-down control over such reflexes. The fact that these process-specific age effects remained concealed in overall oculomotor performance analyses emphasizes the utility of looking beyond the surface; indeed, there may be more than meets the eye.

  5. Physical activity and telomere length: Impact of aging and potential mechanisms of action.

    PubMed

    Arsenis, Nicole C; You, Tongjian; Ogawa, Elisa F; Tinsley, Grant M; Zuo, Li

    2017-03-30

    Telomeres protect the integrity of information-carrying DNA by serving as caps on the terminal portions of chromosomes. Telomere length decreases with aging, and this contributes to cell senescence. Recent evidence supports that telomere length of leukocytes and skeletal muscle cells may be positively associated with healthy living and inversely correlated with the risk of several age-related diseases, including cancer, cardiovascular disease, obesity, diabetes, chronic pain, and stress. In observational studies, higher levels of physical activity or exercise are related to longer telomere lengths in various populations, and athletes tend to have longer telomere lengths than non-athletes. This relationship is particularly evident in older individuals, suggesting a role of physical activity in combating the typical age-induced decrements in telomere length. To date, a small number of exercise interventions have been executed to examine the potential influence of chronic exercise on telomere length, but these studies have not fully established such relationship. Several potential mechanisms through which physical activity or exercise could affect telomere length are discussed, including changes in telomerase activity, oxidative stress, inflammation, and decreased skeletal muscle satellite cell content. Future research is needed to mechanistically examine the effects of various modalities of exercise on telomere length in middle-aged and older adults, as well as in specific clinical populations.

  6. More than Meets the Eye: Age Differences in the Capture and Suppression of Oculomotor Action

    PubMed Central

    Ridderinkhof, K. Richard; Wijnen, Jasper G.

    2011-01-01

    Salient visual stimuli capture attention and trigger an eye-movement toward its location reflexively, regardless of an observer’s intentions. Here we aim to investigate the effect of aging (1) on the extent to which salient yet task-irrelevant stimuli capture saccades, and (2) on the ability to selectively suppress such oculomotor responses. Young and older adults were asked to direct their eyes to a target appearing in a stimulus array. Analysis of overall performance shows that saccades to the target object were disrupted by the appearance of a task-irrelevant abrupt-onset distractor when the location of this distractor did not coincide with that of the target object. Conditional capture function analyses revealed that, compared to young adults, older adults were more susceptible to oculomotor capture, and exhibited deficient selective suppression of the responses captured by task-irrelevant distractors. These effects were uncorrelated, suggesting two independent sources off age-related decline. Thus, with advancing age, salient visual distractors become more distracting; in part because they trigger reflexive eye-movements more potently; in part because of failing top-down control over such reflexes. The fact that these process-specific age effects remained concealed in overall oculomotor performance analyses emphasizes the utility of looking beyond the surface; indeed, there may be more than meets the eye. PMID:22046165

  7. Regulatory action and moderate decrease in methylphenidate use among ADHD diagnosed patients aged five and under in Korea.

    PubMed

    Shin, Ju-Young; Lee, Shin Haeng; Shin, Sun Mi; Shin, Han Na; Park, Byung-Joo

    2015-07-01

    In December 2009, Korean regulatory agency announced that methylphenidate, a drug used to treat attention deficit-hyperactivity disorder (ADHD), should not be used in children aged five and under due to the risk of sudden cardiac death. This study examined the impact of regulatory action and prescribing patterns. We conducted a time series analysis using the Korea National Health Insurance Service database. Study subjects included children under 18years old with ADHD from January 2007 to December 2011. Contraindicated use of methylphenidate was defined as use of methylphenidate at least once in children aged five and under. We selected additional control points (2007, 2008, and 2010) and compared the methylphenidate use one year before and after each point. We calculated relative and absolute reductions, and 95% confidence intervals. The total number of ADHD patients was 376,298. Overall, there was a 70.87% relative reduction (95% CI: 63.33%-79.31%) and a 0.93% absolute reduction (95% CI: 0.51%-0.60%) of methylphenidate use. The relative and absolute reductions were 27.61% (95% CI: 24.76%-30.78%) and 0.31% (95% CI: 0.21%-0.41%) in 2007; 43.58% (95% CI: 38.02%-49.96%) and 0.35% (95% CI: 0.27%-0.43%) in 2008; 46.52% (95% CI: 38.86%-55.70%) and 0.21 (95% CI: 0.15%-0.27%) in 2009; and 10.20% (95% CI: 8.32%-12.50%) and 0.02% (95% CI: 0.02%-0.07%) in 2010. Korean regulatory action led to a moderate decrease in contraindicated methylphenidate use even after the steep decline before the regulatory action.

  8. Plenty of action left in northern Europe's middle-aged offshore

    SciTech Connect

    Knott, D.J.

    1994-08-15

    Northern Europe's offshore oil industry this year has begun to reveal several symptoms generally associated with middle age. Though in its prime in terms of oil production, North Sea industry has begun a dramatic slimming program. It has started a search for fresh experiences, and it has begun to revisit the big successes of its youth. The paper cites examples demonstrating these trends. The paper then discusses production, outlook for exploration, trends in the United Kingdom, development advances in the natural gas industry, exploration activities, and redevelopment projects.

  9. 45 CFR 91.33 - Assurance of compliance and recipient assessment of age distinctions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Assurance of compliance and recipient assessment... assessment of age distinctions. (a) Each recipient of Federal financial assistance from HHS shall sign a written assurance as specified by HHS that it will comply with the Act and these regulations....

  10. Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart.

    PubMed

    Abete, P; Testa, G; Galizia, G; Mazzella, F; Della Morte, D; de Santis, D; Calabrese, C; Cacciatore, F; Gargiulo, G; Ferrara, N; Rengo, G; Sica, V; Napoli, C; Rengo, F

    2005-01-01

    Ischemic preconditioning (IP) has been proposed as an endogenous form of protection against ischemia reperfusion injury. IP, however, does not prevent post-ischemic dysfunction in the aging heart but may be partially corrected by exercise training and food restriction. We investigated the role of exercise training combined with food restriction on restoring IP in the aging heart. Effects of IP against ischemia-reperfusion injury in isolated hearts from adult (A, 6 months old), sedentary 'ad libitum' fed (SL), trained ad libitum fed (TL), sedentary food-restricted (SR), trained- and food-restricted senescent rats (TR) (24 months old) were investigated. Norepinephrine release in coronary effluent was determined by high performance liquid cromatography. IP significantly improved final recovery of percent developed pressure in hearts from A (p<0.01) but not in those from SL (p=NS) vs unconditioned controls. Developed pressure recovery was partial in hearts from TL and SR (64.3 and 67.3%, respectively; p<0.05 vs controls) but it was total in those from TR (82.3%, p=NS vs A; p<0.05 vs hearts from TL and SR). Similarly, IP determined a similar increase of norepinephrine release in A (p<0.001) and in TR (p<0.001, p=NS vs adult). IP was abolished by depletion of myocardial norepinephrine stores by reserpine in all groups. Thus, IP reduces post-ischemic dysfunction in A but not in SL. Moreover, IP was preserved partially in TR and SR and totally in TR. Complete IP maybe due to full restoration of norepinephrine release in response to IP stimulus.

  11. Effect of Aging on Motor Inhibition during Action Preparation under Sensory Conflict

    PubMed Central

    Duque, Julie; Petitjean, Charlotte; Swinnen, Stephan P.

    2016-01-01

    Motor behaviors often require refraining from selecting options that may be part of the repertoire of natural response tendencies but that are in conflict with ongoing goals. The presence of sensory conflict has a behavioral cost but the latter can be attenuated in contexts where control processes are recruited because conflict is expected in advance, producing a behavioral gain compared to contexts where conflict occurs in a less predictable way. In the present study, we investigated the corticospinal correlates of these behavioral effects (both conflict-driven cost and context-related gain). To do so, we measured motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) of young and healthy older adults performing the Eriksen Flanker Task. Subjects performed button-presses according to a central arrow, flanked by irrelevant arrows pointing in the same (congruent trial) or opposite direction (incongruent trial). Conflict expectation was manipulated by changing the probability of congruent and incongruent trials in a given block. It was either high (mostly incongruent blocks, MIB, 80% incongruent trials) or low (mostly congruent blocks, MCB, 80% congruent). The MEP data indicate that the conflict-driven behavioral cost is associated with a strong increase in inappropriate motor activity regardless of the age of individuals, as revealed by larger MEPs in the non-responding muscle in incongruent than in congruent trials. However, this aberrant facilitation disappeared in both groups of subjects when conflict could be anticipated (i.e., in the MIBs) compared to when it occurred in a less predictably way (MCBs), probably allowing the behavioral gain observed in both the young and the older individuals. Hence, the ability to overcome and anticipate conflict was surprisingly preserved in the older adults. Nevertheless, some control processes are likely to evolve with age because the behavioral gain observed in

  12. NCI at Frederick Team Receives 2014 HHS Green Champions Award | Poster

    Cancer.gov

    A team of NCI and Leidos Biomedical Research employees at NCI at Frederick received the Energy and Fleet Management Award, one of the 2014 Department of Health and Human Services (HHS) Green Champions Awards, for comparing the costs and energy usage of two -80°C freezer technologies. This was the first scientific study to be jointly conducted by Leidos Biomedical Research’s Applied and Developmental Research Directorate (ADRD) and Facilities Maintenance and Engineering Directorate (FME).  

  13. Protective action of green tea catechins in neuronal mitochondria during aging.

    PubMed

    Assuncao, Marco; Andrade, Jose Paulo

    2015-01-01

    Mitochondria are central players in the regulation of cell homeostasis. They are essential for energy production but at the same time, reactive oxygen species accumulate as byproducts of the electron transport chain causing mitochondrial damage. In the central nervous system, senescence and neurodegeneration occur as a consequence of mitochondrial oxidative insults and impaired electron transfer. The accumulation of several oxidation products in neurons during aging prompts the idea that consumption of antioxidant compounds may delay neurodegenerative processes. Tea, one of the most consumed beverages in the world, presents benefits to human health that have been associated to its abundance in polyphenols, mainly catechins, that possess powerful antioxidant properties in vivo and in vitro. In this review, the focus will be placed on the effects of green tea catechins in neuronal mitochondria. Although these compounds reach the brain in small quantities, there are several possible targets, signaling pathways and molecular machinery impinging in the mitochondria that will be highlighted. Accumulated evidence thus far seems to indicate that catechins help prevent neurodegeneration and delay brain function decline.

  14. Action Imitation at 1.5 Years Is Better than Pointing Gesture in Predicting Late Development of Language Production at 3 Years of Age

    ERIC Educational Resources Information Center

    Zambrana, Imac M.; Ystrom, Eivind; Schjolberg, Synnve; Pons, Francisco

    2013-01-01

    This study examined whether poor pointing gestures and imitative actions at 18 months of age uniquely predicted late language production at 36 months, beyond the role of poor language at 18 months of age. Data from the Norwegian Mother and Child Cohort Study were utilized. Maternal reports of the children's nonverbal skills and language were…

  15. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline.

    PubMed

    Huffman, Derek M; Farias Quipildor, Gabriela; Mao, Kai; Zhang, Xueying; Wan, Junxiang; Apontes, Pasha; Cohen, Pinchas; Barzilai, Nir

    2016-02-01

    Low insulin-like growth factor-1 (IGF-1) signaling is associated with improved longevity, but is paradoxically linked with several age-related diseases in humans. Insulin-like growth factor-1 has proven to be particularly beneficial to the brain, where it confers protection against features of neuronal and cognitive decline. While aging is characterized by central insulin resistance in the face of hyperinsulinemia, the somatotropic axis markedly declines in older humans. Thus, we hypothesized that increasing IGF-1 in the brain may prove to be a novel therapeutic alternative to overcome central insulin resistance and restore whole-body insulin action in aging. Utilizing hyperinsulinemic-euglycemic clamps, we show that old insulin-resistant rats with age-related declines in IGF-1 level demonstrate markedly improved whole-body insulin action, when treated with central IGF-1, as compared to central vehicle or insulin (P < 0.05). Furthermore, central IGF-1, but not insulin, suppressed hepatic glucose production and increased glucose disposal rates in aging rats (P < 0.05). Taken together, IGF-1 action in the brain and periphery provides a 'balance' between its beneficial and detrimental actions. Therefore, we propose that strategies aimed at 'tipping the balance' of IGF-1 action centrally are the optimal approach to achieve healthy aging and longevity in humans.

  16. A Delphi Study to Detect Deficiencies and Propose Actions in Real Life Treatment of Neovascular Age-Related Macular Degeneration

    PubMed Central

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S.; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment. PMID:25587438

  17. A delphi study to detect deficiencies and propose actions in real life treatment of neovascular age-related macular degeneration.

    PubMed

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Gallego-Pinazo, Roberto; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment.

  18. Acceptable Risk? The Nuclear Age in the United States. Study/Action Guide [and] Companion to Study/Action Guide for Congregations and Religious Groups.

    ERIC Educational Resources Information Center

    American Friends Service Committee, Philadelphia, PA. National Action/Research on the Military Industrial Complex.

    A study-action guide and a companion guide are intended to help citizens explore some of the challenging dilemmas of U.S. nuclear policy. The two guides place strong emphasis on group discussion and participation as well as action citizens might want to take to bring about a non-nuclear world. The companion guide is intended for congregations and…

  19. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Actions for violating an order or for disruptive... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  20. 42 CFR 93.515 - Actions for violating an order or for disruptive conduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Actions for violating an order or for disruptive... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions Hearing Process § 93.515 Actions for violating an order or...

  1. European silver paper on the future of health promotion and preventive actions, basic research and clinical aspects of age-related disease.

    PubMed

    Cruz-Jentoft, Alfonso J; Franco, Alain; Sommer, Pascal; Baeyens, Jean-Pierre; Jankowska, Ewa; Maggi, Adriana; Ponikowski, Piotr; Ryś, Andrzej; Szczerbińska, Katarzyna; Diseases, Andrzej Milewicz And All Other Participants Of European Summit-Age-Related

    2009-01-01

    The current article is a statement of the meeting with international and multidisciplinary participation, held in Wrocław, Poland on September 11-13, 2008. The meeting was devoted to working out a position focusing on the challenge for individuals, health care systems, biological, psychosocial, epidemiological, medical, and public health sciences in the ageing populations of the twenty-first century. The statement is presented as an overview, in tabular format, of the current European situation regarding basic biological research on ageing, health promotion and preventive action, clinical care for older people, and recommendations for future actions.

  2. Gag rule delay dropped, rape-incest exception kept by Senate in HHS bill.

    PubMed

    1992-09-22

    The joint conference committee currently meeting to resolve differences between the US Senate and House versions of a Labor, Health and Human Services (HHS), and Education appropriations bill has a tight bottom line and few controversial provisions. With language to overturn the gag rule already deleted, pro-choice congressional advocates hope that the bill sent to President Bush will include the provision accepted by the Senate last week to allow federal funding under Medicaid for abortions in cases of rape and incest. The House, by a vote of 345 to 54, passed the Labor-HHS appropriations bill which grew to $244 billion for fiscal 1993; nearly 3/4 of the appropriation--$179 billion--would be reserved for entitlement programs (Medicare, Medicaid, Aid to Families with Dependent Children). The remainder would be for discretionary spending. The Senate continued the same Spartan tone, though some programs received additional funds; none of the increased funds were designated for Title III early intervention and prevention programs. Women's health research received additional funding, as did the Title X family planning program. As usual with this contentious legislation, a plethora of amendments were offered. On funding issues, the most controversial were 3 that sought to "break down the walls" and allow the transfer of funds from the defense discretionary account into the domestic discretionary account. Among the 65 threatened amendments, the most widely anticipated and feared, were those of Sen. Jesse Helms, who has long favored the Labor-HHS bill as a venue for restrictive social policy amendment. He threatened an amendment restricting the use of federal funds for the purchase or distribution of condoms, particularly for school-based condom availability. Helms backed down from offering any condom-related amendment, reportedly after a lengthy and pointed discussion with other Republicans who convinced him that this time he had been out organized.

  3. Emerging Perception of Causality in Action-and-Reaction Sequences from 4 to 6 Months of Age: Is It Domain-Specific?

    ERIC Educational Resources Information Center

    Schlottmann, Anne; Ray, Elizabeth D.; Surian, Luca

    2012-01-01

    Two experiments (N=136) studied how 4- to 6-month-olds perceive a simple schematic event, seen as goal-directed action and reaction from 3 years of age. In our causal reaction event, a red square moved toward a blue square, stopping prior to contact. Blue began to move away before red stopped, so that both briefly moved simultaneously at a…

  4. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

    PubMed

    Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, E H; Bewick, M; Chavannes, N H; de Sousa, J Correia; Cruz, A A; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, C A; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, A K; Barbara, C; Bateman, E D; Beghé, B; Kheder, A Ben; Bennoor, K S; Benson, M; Bergmann, K C; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, A L; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, L P; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Burney, P G; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, M A; Calverley, P M; Camargos, P A M; Canonica, G W; Camuzat, T; Carlsen, K H; Carr, W; Carriazo, A; Casale, T; Cepeda Sarabia, A M; Chatzi, L; Chen, Y Z; Chiron, R; Chkhartishvili, E; Chuchalin, A G; Chung, K F; Ciprandi, G; Cirule, I; Cox, L; Costa, D J; Custovic, A; Dahl, R; Dahlen, S E; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; De Manuel Keenoy, E; Demoly, P; Denburg, J A; Devillier, P; Didier, A; Dinh-Xuan, A T; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Dykewicz, M S; El-Gamal, Y; Emuzyte, R; Fabbri, L M; Fletcher, M; Fiocchi, A; Fink Wagner, A; Fonseca, J; Fokkens, W J; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioğlu, B; Gereda, J E; González Diaz, S; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, M A; Heaney, L G; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, J O' B; Howarth, P; Humbert, M; Hyland, M E; Illario, M; Ivancevich, J C; Jardim, J R; Jares, E J; Jeandel, C; Jenkins, C; Johnston, S L; Jonquet, O; Julge, K; Jung, K S; Just, J; Kaidashev, I; Kaitov, M R; Kalayci, O; Kalyoncu, A F; Keil, T; Keith, P K; Klimek, L; Koffi N'Goran, B; Kolek, V; Koppelman, G H; Kowalski, M L; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Li, J; Lodrup Carlsen, K; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, M J; Manning, P; Mara, S; Marshall, G D; Masjedi, M R; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Menzies-Gow, A; Merk, H; Michel, J P; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, G M Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, T D; O'Hehir, R E; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, H S; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, T A; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, K F; Raciborski, F; Radier Pontal, F; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, G K; Schunemann, H J; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, F E R; Sisul, J C; Skrindo, I; Smit, H A; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, P J; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, A L; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, D Y; Wahn, U; Wickman, M; Williams, D M; Williams, S; Wright, J; Yawn, B P; Yiallouros, P K; Yusuf, O M; Zaidi, A; Zar, H J; Zernotti, M E; Zhang, L; Zhong, N; Zidarn, M; Mercier, J

    2016-01-01

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.

  5. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  6. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  7. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  8. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  9. 45 CFR 91.11 - Rules against age discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Rules against age discrimination. 91.11 Section 91... THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.11 Rules against age discrimination. The rules stated in...

  10. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exceptions to the rules against age discrimination... FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.14 Exceptions to the rules against age discrimination: Reasonable factors other than age. A recipient is permitted to take an...

  11. Aging

    PubMed Central

    Park, Dong Choon

    2013-01-01

    Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction. PMID:24653904

  12. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... misconduct and administrative actions. 93.501 Section 93.501 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...

  13. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications...

  14. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications...

  15. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications...

  16. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications...

  17. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications...

  18. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  19. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  20. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  1. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  2. 42 CFR 55a.103 - What criteria has HHS established for deciding which grant application to fund?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What criteria has HHS established for deciding which grant application to fund? 55a.103 Section 55a.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions §...

  3. 42 CFR 1007.20 - Circumstances in which data mining is permissible and approval by HHS Office of Inspector General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Circumstances in which data mining is permissible... CONTROL UNITS § 1007.20 Circumstances in which data mining is permissible and approval by HHS Office of Inspector General. (a) Notwithstanding § 1007.19(e)(2), a MFCU may engage in data mining as defined in...

  4. 42 CFR 1007.20 - Circumstances in which data mining is permissible and approval by HHS Office of Inspector General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Circumstances in which data mining is permissible... CONTROL UNITS § 1007.20 Circumstances in which data mining is permissible and approval by HHS Office of Inspector General. (a) Notwithstanding § 1007.19(e)(2), a MFCU may engage in data mining as defined in...

  5. 77 FR 73117 - Patient Protection and Affordable Care Act; HHS Notice of Benefit and Payment Parameters for 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    .... Treatment of Premium Stabilization Payments, and Timing of Annual MLR Reports and Distribution of Rebates 2... health insurance issuers to submit an annual MLR report to HHS and provide rebates to consumers if they... adjustment, reinsurance, and risk corridors, and to change the timing of the annual MLR report...

  6. Analysis of newspaper coverage of active aging through the lens of the 2002 World Health Organization Active Ageing Report: A Policy Framework and the 2010 Toronto Charter for Physical Activity: A Global Call for Action.

    PubMed

    Abdullah, Boushra; Wolbring, Gregor

    2013-12-05

    As populations continue to grow older, efforts to support the process of aging well are important goals. Various synonyms are used to cover aging well, such as active aging. The World Health Organization published in 2002 the report Active Ageing: A Policy Framework that according to the call for papers, has brought active ageing to the forefront of international public health awareness. The 2010 Toronto Charter for Physical Activity: A Global Call for Action was singled out in the call for papers as a key document promoting physical activity one goal of the 2002 WHO active aging policy framework. Media are to report to the public topics of importance to them. We investigated the newspaper coverage of aging well and synonymous terms such as active aging through the lens of the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity. As sources we used the following newspapers: China Daily, The Star (Malaysia), two UK newspapers (The Guardian, The Times), a database of 300 Canadian newspapers (Canadian Newsstand) and a US newspaper (The New York Times). The study generated data answering the following four research questions: (1) how often are the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity mentioned; (2) how often is the topic of active aging and terms conveying similar content (aging well, healthy aging, natural aging and successful aging) discussed; (3) which of the issues flagged as important in the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity are covered in the newspaper coverage of active aging and synonymous terms; (4) which social groups were mentioned in the newspapers covered. The study found a total absence of mentioning of the two key documents and a low level of coverage of "active aging" and terms conveying similar content. It found further a lack of engagement with the issues raised in the two key documents and a low level of

  7. 45 CFR 91.14 - Exceptions to the rules against age discrimination: Reasonable factors other than age.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Exceptions to the rules against age discrimination: Reasonable factors other than age. 91.14 Section 91.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.14 Exceptions to the...

  8. Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.

    PubMed

    Guerrieri, Elena; Mallareddy, Jayapal Reddy; Tóth, Géza; Schmidhammer, Helmut; Spetea, Mariana

    2015-03-18

    Herein we report the radiolabeling and pharmacological investigation of a novel radioligand, the N-cyclobutylmethyl substituted diphenethylamine [(3)H]HS665, designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders). HS665 was prepared in tritium-labeled form by a dehalotritiated method resulting in a specific activity of 30.65 Ci/mmol. Radioligand binding studies were performed to establish binding properties of [(3)H]HS665 to the recombinant human KOP receptor in membranes from Chinese hamster ovary cells stably expressing human KOP receptors (CHOhKOP) and to the native neuronal KOP receptor in guinea pig brain membranes. Binding of [(3)H]HS665 was specific and saturable in both tissue preparations. A single population of high affinity binding sites was labeled by [(3)H]HS665 in membranes from CHOhKOP cells and guinea pig brain with similar equilibrium dissociation constants, Kd, 0.45 and 0.64 nM, respectively. Average receptor density of [(3)H]HS665 recognition sites were 5564 and 154 fmol/mg protein in CHOhKOP cells and guinea pig brain, respectively. This study shows that the new radioligand distinguishes and labels KOP receptors specifically in neuronal and cellular systems expressing KOP receptors, making this molecule a valuable tool in probing structural and functional mechanisms governing ligand-KOP receptor interactions in both a recombinant and native in vitro setting.

  9. Analysis of Newspaper Coverage of Active Aging through the Lens of the 2002 World Health Organization Active Ageing Report: A Policy Framework and the 2010 Toronto Charter for Physical Activity: A Global Call for Action

    PubMed Central

    Abdullah, Boushra; Wolbring, Gregor

    2013-01-01

    As populations continue to grow older, efforts to support the process of aging well are important goals. Various synonyms are used to cover aging well, such as active aging. The World Health Organization published in 2002 the report Active Ageing: A Policy Framework that according to the call for papers, has brought active ageing to the forefront of international public health awareness. The 2010 Toronto Charter for Physical Activity: A Global Call for Action was singled out in the call for papers as a key document promoting physical activity one goal of the 2002 WHO active aging policy framework. Media are to report to the public topics of importance to them. We investigated the newspaper coverage of aging well and synonymous terms such as active aging through the lens of the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity. As sources we used the following newspapers: China Daily, The Star (Malaysia), two UK newspapers (The Guardian, The Times), a database of 300 Canadian newspapers (Canadian Newsstand) and a US newspaper (The New York Times). The study generated data answering the following four research questions: (1) how often are the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity mentioned; (2) how often is the topic of active aging and terms conveying similar content (aging well, healthy aging, natural aging and successful aging) discussed; (3) which of the issues flagged as important in the 2002 WHO active aging policy framework and the 2010 Toronto Charter for Physical Activity are covered in the newspaper coverage of active aging and synonymous terms; (4) which social groups were mentioned in the newspapers covered. The study found a total absence of mentioning of the two key documents and a low level of coverage of “active aging” and terms conveying similar content. It found further a lack of engagement with the issues raised in the two key documents and a low level

  10. The Control of Instrumental Action Following Outcome Devaluation in Young Children Aged between 1 and 4 Years

    ERIC Educational Resources Information Center

    Klossek, U. M. H.; Russell, J.; Dickinson, A.

    2008-01-01

    To determine the role of action-outcome learning in the control of young children's instrumental behavior, the authors trained 18- to 48-month-olds to manipulate visual icons on a touch-sensitive display to obtain different types of video clips as outcomes. Subsequently, one of the outcomes was devalued by repeated exposure, and children's…

  11. Differential Effects of Age-of-Acquisition for Concrete Nouns and Action Verbs: Evidence for Partly Distinct Representations?

    ERIC Educational Resources Information Center

    Boulenger, Veronique; Decoppet, Nathalie; Roy, Alice C.; Paulignan, Yves; Nazir, Tatjana A.

    2007-01-01

    There is growing evidence that words that are acquired early in life are processed faster and more accurately than words acquired later, even by adults. As neuropsychological and neuroimaging studies have implicated different brain networks in the processing of action verbs and concrete nouns, the present study was aimed at contrasting reaction…

  12. 78 FR 42086 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for Action Level for Arsenic in Apple Juice; A Quantitative Assessment of Inorganic Arsenic in Apple Juice; Availability AGENCY: Food and Drug Administration, HHS....

  13. 77 FR 70955 - FDA Actions Related to Nicotine Replacement Therapies and Smoking-Cessation Products; Report to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 15 FDA Actions Related to Nicotine Replacement... Tobacco Dependence; Public Hearing; Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public hearing; request for comments. SUMMARY: The Food and Drug Administration (FDA)...

  14. How the mode of action affects evidence of planning and movement kinematics in aging: End-state comfort in older adults.

    PubMed

    Scharoun, Sara M; Gonzalez, Dave A; Roy, Eric A; Bryden, Pamela J

    2016-05-01

    Motor deficits are commonly observed with age; however, it has been argued that older adults are more adept when acting in natural tasks and do not differ from young adults in these contexts. This study assessed end-state comfort and movement kinematics in a familiar task to examine this further. Left- and right-handed older adults picked up a glass (upright or overturned) as if to pour water in four modes of action (pantomime, pantomime with image/cup as a guide, actual grasping). With increasing age, a longer deceleration phase (in pantomime without a stimulus) and less end-state comfort (in pantomime without a stimulus and image as a guide) was displayed as the amount of contextual information available to guide movement decreased. Changes in movement strategies likely reflect an increased reliance on feedback control and demonstration of a more cautious movement. A secondary aim of this study was to assess hand preference and performance, considering conflicting reports of manual asymmetries with age. Performance differences in the Grooved Pegboard place task indicate left handers may display a shift towards right handedness in some, but not all cases. Summarizing, this study supports age-related differences in planning and control processes in a familiar task, and changes in manual asymmetries with age in left handers.

  15. The bare essentials. Release of LOM report leaves HHS to determine what should be covered by health benefits packages.

    PubMed

    Zigmond, Jessica

    2011-10-10

    In the wake of an IOM report on the criteria HHS should use to determine what benefits will be "essential" under reform, various stakeholders are weighing in. The National Association of Public Hospitals and Health Systems would like "enabling" services--such as language, transportation and case-management services--included, because they help make medical care more effective, says Xiaoyi Huang, left, of the NAPH.

  16. 45 CFR 91.1 - What is the purpose of the Age Discrimination Act of 1975?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false What is the purpose of the Age Discrimination Act... ASSISTANCE FROM HHS General § 91.1 What is the purpose of the Age Discrimination Act of 1975? The Age Discrimination Act of 1975, as amended, is designed to prohibit discrimination on the basis of age in programs...

  17. 75 FR 43995 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: July 21, 2010... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Healthy Aging; Search for Mechanisms....

  18. 78 FR 55267 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Clinical Aging Review Committee. Date:...

  19. 76 FR 22407 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ..., Aging Research, National Institutes of Health, HHS) Dated: April 14, 2011. Jennifer S. Spaeth, Director... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Aging and Mobility. Date: May 12, 2011....

  20. "I want to be 100 years old, but I smoke too much": Exploring the gap between positive aging goals and reported preparatory actions in different social circumstances.

    PubMed

    Craciun, Catrinel; Flick, Uwe

    2015-12-01

    Preparing for positive aging is shaped by the social context a person lives in. The present qualitative study explores and compares representations about preparatory actions in precarious workers (i.e., with temporary job contracts and insecure pension plans) and individuals with secure pension plans living in Germany. It also examines, the discrepancy between what middle-aged persons think they should be doing in preparation and what they report doing for aging well. Findings from the analysis of the semi-structured interviews conducted here show that people who have insecure pension plans tend to see themselves as social networkers and optimists, while those with secure pension plans see themselves as social activists and careful planners of old age. All participants value an active, healthy body but manage to do little in order to attain it due to lacking time and discipline. In accordance with the socioemotional selectivity theory, perceiving a short-time perspective makes precarious individuals focus on emotional goals, while financially secure individuals value social goals. Implications for practice and policy change are discussed.

  1. 78 FR 277 - Food and Drug Administration Actions Related to Nicotine Replacement Therapies and Smoking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ... goals: (1) Total abstinence from tobacco use, (2) reductions in consumption of tobacco, and (3... Tobacco Dependence; Public Hearing; Extension of Comment Period AGENCY: Food and Drug Administration, HHS... innovative products and treatments for tobacco dependence. The Agency is taking this action to...

  2. 76 FR 2691 - Prescription Drug Products Containing Acetaminophen; Actions To Reduce Liver Injury From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... To Reduce Liver Injury From Unintentional Overdose AGENCY: Food and Drug Administration, HHS. ACTION... safety to help prevent liver damage due to acetaminophen overdosing, a serious public health problem...-containing prescription drug products to address new safety information about the risk of liver damage....

  3. Shift from depolarizing to hyperpolarizing glycine action in rat auditory neurones is due to age-dependent Cl− regulation

    PubMed Central

    Ehrlich, Ingrid; Löhrke, Stefan; Friauf, Eckhard

    1999-01-01

    The inhibitory neurotransmitter glycine can elicit depolarizing responses in immature neurones. We investigated the changes in glycine responses and their ionic mechanism in developing neurones of the rat lateral superior olive (LSO), an auditory brainstem nucleus involved in sound localization. Whole-cell and gramicidin perforated-patch recordings were performed from visually identified LSO neurones in brain slices and glycine was pressure applied for 3–100 ms to the soma. Glycine-evoked currents were reversibly blocked by strychnine. They were mostly monophasic, but biphasic responses occurred in ∼30% of P8-11 neurones in perforated-patch recordings. In whole-cell recordings from P2-11 neurones, the reversal potential of glycine-evoked currents (EGly) was determined by the transmembranous Cl− gradient and corresponded closely to the Nernst potential for Cl−, regardless of age. This indicates that Cl− is the principle ion permeating glycine receptors, but is also consistent with a low relative (10–20%) permeability for HCO3−. The Cl− gradient also determined the polarity and amplitude of glycine-evoked membrane potential changes. Leaving the native intracellular [Cl−] undisturbed with gramicidin perforated-patch recordings, we found a highly significant, age-dependent change of EGly from −46.8 ± 1.8 mV (P1-4, n = 28) to −67.6 ± 3.3 mV (P5-8, n = 10) to −82.2 ± 4.1 mV (P9–11, n = 18). The majority of P1–4 neurones were depolarized by glycine (∼80%) and spikes were evoked in ∼30%. In contrast, P9–11 neurones were hyperpolarized. In perforated-patch recordings, EGly was influenced by the voltage protocol and the glycine application interval; it could be shifted in the positive and negative direction. For a given application interval, these shifts were always larger in P1–4 than in P8–11 neurones, pointing to less effective Cl− regulation mechanisms in younger neurones. Furosemide (frusemide), a blocker of cation

  4. Late-onset temperature reduction can retard the aging process in aged fish via a combined action of an anti-oxidant system and the insulin/insulin-like growth factor 1 signaling pathway.

    PubMed

    Wang, Xia; Chang, Qingyun; Wang, Yu; Su, Feng; Zhang, Shicui

    2014-12-01

    Two different mechanisms are considered to be related to aging. Cumulative molecular damage caused by reactive oxygen species (ROS), the by-products of oxidative phosphorylation, is one of these mechanisms (ROS concept). Deregulated nutrient sensing by the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway is the second mechanism (IIS concept). Temperature reduction (TR) is known to modulate aging and prolong life span in a variety of organisms, but the mechanisms remain poorly defined. Here we first demonstrate that late-onset TR from 26 °C to 22 °C extends mean life span and maximum life span by approximately 5.2 and 3 weeks, respectively, in the annual fish Nothobranchius guentheri. We then show that TR is able to decrease the accumulation of the histological aging markers senescence-associated β-galactosidase (SA-β-Gal) in the epithelium and lipofuscin (LF) in the liver and to reduce protein oxidation and lipid peroxidation levels in the muscle. We also show that TR can enhance the activities of catalase, glutathione peroxidase, and superoxide dismutase, and stimulate the synthesis of SirT1 and FOXO3A/FOXO1A, both of which are the downstream regulators of the IIS pathway. Taken together, our findings suggest that late-onset TR, a simple non-intrusion intervention, can retard the aging process in aged fish, resulting in their life span extension, via a synergistic action of an anti-oxidant system and the IIS pathway. This also suggests that combined assessment of the ROS and IIS concepts will contribute to providing a more comprehensive view of the anti-aging process.

  5. Late-Onset Temperature Reduction Can Retard the Aging Process in Aged Fish Via a Combined Action of an Anti-Oxidant System and the Insulin/Insulin-Like Growth Factor 1 Signaling Pathway

    PubMed Central

    Wang, Xia; Chang, Qingyun; Wang, Yu; Su, Feng

    2014-01-01

    Abstract Two different mechanisms are considered to be related to aging. Cumulative molecular damage caused by reactive oxygen species (ROS), the by-products of oxidative phosphorylation, is one of these mechanisms (ROS concept). Deregulated nutrient sensing by the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway is the second mechanism (IIS concept). Temperature reduction (TR) is known to modulate aging and prolong life span in a variety of organisms, but the mechanisms remain poorly defined. Here we first demonstrate that late-onset TR from 26°C to 22°C extends mean life span and maximum life span by approximately 5.2 and 3 weeks, respectively, in the annual fish Nothobranchius guentheri. We then show that TR is able to decrease the accumulation of the histological aging markers senescence-associated β-galactosidase (SA-β-Gal) in the epithelium and lipofuscin (LF) in the liver and to reduce protein oxidation and lipid peroxidation levels in the muscle. We also show that TR can enhance the activities of catalase, glutathione peroxidase, and superoxide dismutase, and stimulate the synthesis of SirT1 and FOXO3A/FOXO1A, both of which are the downstream regulators of the IIS pathway. Taken together, our findings suggest that late-onset TR, a simple non-intrusion intervention, can retard the aging process in aged fish, resulting in their life span extension, via a synergistic action of an anti-oxidant system and the IIS pathway. This also suggests that combined assessment of the ROS and IIS concepts will contribute to providing a more comprehensive view of the anti-aging process. PMID:25298234

  6. 76 FR 4927 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: January 20, 2011. Jennifer... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Beeson Review. Date: February 18, 2011....

  7. 77 FR 64525 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ..., Aging Research, National Institutes of Health, HHS) Dated: October 15, 2012. Melanie J. Gray, Program... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Tuberculosis Infection in the Elderly....

  8. 78 FR 55265 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: September 4, 2013... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Heart Failure. Date: October 3, 2013. Time:...

  9. 76 FR 11798 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ....866, Aging Research, National Institutes of Health, HHS) Dated: February 25, 2011. Jennifer S. Spaeth... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Member Conflict. Date: March 15, 2011....

  10. 75 FR 22411 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: April 21, 2010... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Lead Drug Candidates. Date: May 14,...

  11. 78 FR 11212 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: February 11, 2013. Melanie J... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Data Analysis. Date: April 4, 2013. Time:...

  12. 77 FR 74677 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    .... 93.866, Aging Research, National Institutes of Health, HHS) Dated: December 12, 2012. Melanie J. Gray... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Cell Dependent and Independent...

  13. Coordinated Action of Biological Processes during Embryogenesis Can Cause Genome-Wide Linkage Disequilibrium in the Human Genome and Influence Age-Related Phenotypes

    PubMed Central

    Culminskaya, Irina; Kulminski, Alexander M.; Yashin, Anatoli I.

    2017-01-01

    A role of non-Mendelian inheritance in genetics of complex, age-related traits is becoming increasingly recognized. Recently, we reported on two inheritable clusters of SNPs in extensive genome-wide linkage disequilibrium (LD) in the Framingham Heart Study (FHS), which were associated with the phenotype of premature death. Here we address biologically-related properties of these two clusters. These clusters have been unlikely selected randomly because they are functionally and structurally different from matched sets of randomly selected SNPs. For example, SNPs in LD from each cluster are highly significantly enriched in genes (p=7.1×10−22 and p=5.8×10−18), in general, and in short genes (p=1.4×10−47 and p=4.6×10−7), in particular. Mapping of SNPs in LD to genes resulted in two, partly overlapping, networks of 1764 and 4806 genes. Both these networks were gene enriched in developmental processes and in biological processes tightly linked with development including biological adhesion, cellular component organization, locomotion, localization, signaling, (p<10−4, q<10−4 for each category). Thorough analysis suggests connections of these genetic networks with different stages of embryogenesis and highlights biological interlink of specific processes enriched for genes from these networks. The results suggest that coordinated action of biological processes during embryogenesis may generate genome-wide networks of genetic variants, which may influence complex age-related phenotypes characterizing health span and lifespan. PMID:28357417

  14. Anti-Allergic Action of Aged Black Garlic Extract in RBL-2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice

    PubMed Central

    Yoo, Jae-Myung; Sok, Dai-Eun

    2014-01-01

    Abstract Garlic (Allium sativum) has been used as a food as well as a component of traditional medicine. Aged black garlic (ABG) is known to have various bioactivities. However, the effect of ABG on allergic response is almost unknown. In the present study, we investigated whether ABG can inhibit immunoglobulin E-mediated allergic response in RBL-2H3 cells as well as in vivo passive cutaneous anaphylaxis (PCA). In in vitro tests, ethyl acetate extract (EBG) of ABG significantly inhibited the release of β-hexosaminidase (IC50, 1.53 mg/mL) and TNF-α (IC50, 0.98 mg/mL). Moreover, BG10, an active fraction of EBG, dramatically suppressed the release of β-hexosaminidase (IC50, 53.60 μg/mL) and TNF-α (IC50, 27.80 μg/mL). In addition, BG10 completely blocked the formation of prostaglandin E2 and leukotriene B4 at ≥25 μg/mL. When the effect of BG10 on FcɛRI receptor cascade was investigated, BG10 significantly inhibited the phosphorylation of Syk, but not Lyn. Furthermore, BG10 dose dependently decreased the phosphorylation of cytosolic phospholipase A2 (cPLA2) and 5-lipoxygenase (5-LO) as well as the expression of cyclooxygenase-2 (COX-2). Consistent with what has been mentioned earlier, BG10 also significantly inhibited the PCA reaction in mice. In conclusion, these results indicate that ABG suppresses the allergic response, and the mechanism for its anti-allergic action may involve suppressions of Syk, cPLA2, 5-LO, and COX-2. The anti-allergic actions of ABG, EBG, or BG10 suggest that they may be useful as functional foods for allergic diseases. PMID:24456359

  15. Silver paper: the future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease--a report of the European Summit on Age-Related Disease.

    PubMed

    Cruz-Jentoft, Alfonso J; Franco, Alain; Sommer, Pascal; Baeyens, Jean Pierre; Jankowska, Ewa; Maggi, Adriana; Ponikowski, Piotr; Rys, Andrzej; Szczerbinska, Kataryna; Michel, Jean-Pierre; Milewicz, Andrzej

    2009-12-01

    BACKGROUND. In September 2008, under the French Presidency of the European Union and with the support of the Polish Minister of Health, a European Summit on Age-Related Disease was organised inWroclaw (Poland). At this meeting, European politicians, gerontologists and geriatricians gathered to discuss a common approach to future challenges related to age-related disease. Politicians and decision-makers from the European Union and Ministers of Health and their deputies from many European countries raised the problems and difficulties to be tackled in a growing population with a high burden of disease, and asked scientists to write a consensus document with recommendations for future actions and decisions. Scientists and clinicians worked in parallel in three different groups, on health promotion and preventive actions, basic research in age-related disease, and clinical aspects of disease in older people. Beforehand, the format of the paper with recommendations was discussed, and it was finally agreed that, for a better understanding by decision- makers, it would be divided in two different columns: one with facts that were considered settled and agreed by most experts (under the heading We know), and a second with recommendations related to each fact (We recommend). No limit on the number of topics to be discussed was settled. After careful and detailed discussion in each group, which in most cases included the exact wording of each statement, chairpersons presented the results in a plenary session, and new input from all participants was received, until each of the statements and recommendations were accepted by a large majority. Areas with no consensus were excluded from the document. Immediately after the Summit, the chairpersons sent the document both to the main authors and to a list of experts (see footnote) who had made presentations at the summit and agreed to review and critically comment on the final document, which is presented below. As regards the

  16. Age-related variability in performance of a motor action selection task is related to differences in brain function and structure among older adults.

    PubMed

    Stewart, Jill Campbell; Tran, Xuan; Cramer, Steven C

    2014-02-01

    Task performance for behaviors that engage motor cognitive processes may be particularly sensitive to age-related changes. One well-studied model of cognitive motor function involves engagement of action selection (AS) processes. In young adults, task conditions that add AS demands result in increased preparation times and greater engagement of bilateral dorsal premotor (PMd) and parietal cortices. The current study investigated the behavioral and neural response to a change in motor cognitive demands in older adults through the addition of AS to a movement task. Sixteen older adults made a joystick movement under two conditions during functional magnetic resonance imaging. In the AS condition, participants moved right or left based on an abstract rule; in the execution only (EO) condition, participants moved in the same direction on every trial. Across participants, the AS condition, as compared to the EO condition, was associated with longer reaction time and increased activation of left inferior parietal lobule. Variability in behavioral response to the AS task between participants related to differences in brain function and structure. Overall, individuals with poorer AS task performance showed greater activation in left PMd and dorsolateral prefrontal cortex and decreased structural integrity of white matter tracts that connect sensorimotor, frontal, and parietal regions-key regions for AS task performance. Additionally, two distinct patterns of functional connectivity were found. Participants with a pattern of decreased primary motor-PMd connectivity in response to the AS condition, compared to those with a pattern of increased connectivity, were older and had poorer behavioral performance. These neural changes in response to increased motor cognitive demands may be a marker for age-related changes in the motor system and have an impact on the learning of novel, complex motor skills in older adults.

  17. [Definition of "Safety and Hygiene Packages" as a management model for the Hospital Hygiene Service (HHS)].

    PubMed

    Raponi, Matteo; Damiani, Gianfranco; Vincenti, Sara; Wachocka, Malgorzata; Boninti, Federica; Bruno, Stefania; Quaranta, Gianluigi; Moscato, Umberto; Boccia, Stefania; Ficarra, Maria Giovanna; Specchia, Maria Lucia; Posteraro, Brunella; Berloco, Filippo; Celani, Fabrizio; Ricciardi, Walter; Laurenti, Patrizia

    2014-01-01

    The purpose of this research is to identify and formalize the Hospital Hygiene Service activities and products, evaluating them in a cost accounting management view. The ultimate aim, is to evaluate the financial adverse events prevention impact, in an Hospital Hygiene Service management. A three step methodology based on affinity grouping activities, was employed. This methodology led us to identify 4 action areas, with 23 related productive processes, and 86 available safety packages. Owing to this new methodology, we was able to implement a systematic evaluation of the furnished services.

  18. 75 FR 30839 - Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer Match No. 1048, IRS Project No. 241 AGENCY: Department... renewal of an existing computer matching program (CMP) that has an expiration date of June 30,...

  19. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  20. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  1. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  2. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  3. 41 CFR 102-75.495 - May the Department of Education (ED) or the Department of Health and Human Services (HHS) notify...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... surplus real property and related personal property is available for educational and public health... DISPOSAL Surplus Real Property Disposal Property for Educational and Public Health Purposes § 102-75.495... educational and public health purposes? Yes, ED or HHS may notify eligible non-profit institutions that...

  4. 45 CFR Appendix B to Part 5b - Routine Uses Applicable to More Than One System of Records Maintained by HHS

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Routine Uses Applicable to More Than One System of Records Maintained by HHS B Appendix B to Part 5b Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS Pt. 5b, App. B Appendix B to Part 5b—Routine...

  5. 45 CFR Appendix B to Part 5b - Routine Uses Applicable to More Than One System of Records Maintained by HHS

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Routine Uses Applicable to More Than One System of Records Maintained by HHS B Appendix B to Part 5b Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS Pt. 5b, App. B Appendix B to Part 5b—Routine...

  6. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats.

    PubMed

    Vega Rivera, Nelly M; Gallardo Tenorio, Alfredo; Fernández-Guasti, Alonso; Estrada Camarena, Erika

    2016-05-03

    The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE₂) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE₂ (1.25, 2.5 or 5.0 µg/rat, s.c.; -48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE₂ (1.25 µg/rat, s.c., -48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE₂ administration. EE₂ (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE₂ (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE₂ was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE₂ alone or in combination with CIT.

  7. Medical devices; revocation of cardiac pacemaker registry. Food and Drug Administration, HHS. Final rule.

    PubMed

    1999-11-24

    The Food and Drug Administration (FDA) is issuing a final rule to revoke a regulation requiring a cardiac pacemaker registry. The registry, which was mandated by the Deficit Reduction Act of 1984, requires any physician and any provider of services who requests or receives Medicare payment for an implantation, removal, or replacement of permanent cardiac pacemaker devices and pacemaker leads to submit certain information to the registry. The information is used by FDA to track the performance of permanent cardiac pacemakers and pacemaker leads and by the Health Care Finance Administration (HCFA) to administer its Medicare payment program for these devices. This action is being taken to implement an act to Repeal An Unnecessary Medical Device Reporting Requirement passed by Congress in 1996 to remove the cardiac pacemaker registry to eliminate duplicative and unnecessary reporting.

  8. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats

    PubMed Central

    Vega Rivera, Nelly M.; Gallardo Tenorio, Alfredo; Fernández-Guasti, Alonso; Estrada Camarena, Erika

    2016-01-01

    The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE2) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE2 (1.25, 2.5 or 5.0 µg/rat, s.c.; −48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE2 (1.25 µg/rat, s.c., −48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE2 administration. EE2 (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE2 (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE2 was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE2 alone or in combination with CIT. PMID:27153072

  9. Surprise package. HHS delivers its framework for a value-based purchasing system for ambulatory surgery centers, but ASCs are left wondering who will pay.

    PubMed

    Robeznieks, Andis

    2011-04-25

    HHS has offered a framework on value-based purchasing for ambulatory surgery centers. And ASCs say they're ready. "We are very serious about getting this up and running as soon as possible. I think the only thing I could (negatively) speak to would be further delay," says Dr. David Shapiro, left, of the Ambulatory Surgery Center Association. But delay could be inevitable as the initiative has to make its way through the charged health policy environment in Washington.

  10. Choosing Actions

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.

    2013-01-01

    Actions that are chosen have properties that distinguish them from actions that are not. Of the nearly infinite possible actions that can achieve any given task, many of the unchosen actions are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes actions that are chosen from actions that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to action choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769

  11. Action semantics modulate action prediction.

    PubMed

    Springer, Anne; Prinz, Wolfgang

    2010-11-01

    Previous studies have demonstrated that action prediction involves an internal action simulation that runs time-locked to the real action. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal action representations. Moreover, results showed that action semantics modulate action prediction accuracy. The semantic effect was specified by the processing of action verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by action verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between action simulation and action semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of action language.

  12. The Global Energy Crisis: Today and Tomorrow. Developing Proactive Action Student Awareness and Understanding About Finite Fuels and Alternative Energy Sources in a Global Age.

    ERIC Educational Resources Information Center

    Peters, Richard O.

    Background information and a teaching strategy are provided to help students better understand the global energy crisis and learn to take action. An overview of the energy crisis includes a discussion of the unequal distribution of natural resources throughout the world, the finite nature of fossil fuels, and problems associated with the depletion…

  13. Evaluation of freezing point depression osmolality for classifying random urine specimens defined as substituted under HHS/DOT criteria.

    PubMed

    Cook, Janine Denis; Hannon, Mark W; Vo, Tamdan; Caplan, Yale H

    2002-10-01

    This study evaluates the analytical performance characteristics of freezing point depression osmolality in urine and osmolality as a suitable analytical indicator for determining the concentration of urine specimens submitted for workplace drug testing. Specifically, this study attempted to determine the utility of urine osmolality to serve as an indicator of substitution as defined by HHS/SAMHSA criteria. Urine osmolality was validated by determining the accuracy, precision, analytical sensitivity, reportable range, and reference interval for the method. Osmolality was measured in workplace urine specimens (n = 66) with creatinine concentrations < or = 5.0 mg/dL. Comparing the results with the lower limit of the random urine reference intervals for specific gravity (1.002) and osmolality (50 mOsm/kg), 62% had specific gravities < or = 1.001, 52% had osmolalities < 50 mOsm/kg, and 47% had both a creatinine < or = 5.0 mg/dL, specific gravity < or = 1.001 and an osmolality < 50 mOsm/kg. Urine specimens (n = 311) were collected from 35 volunteers enrolled in a controlled water loading study in which at least 80 oz (2370 mL) of fluid was ingested over a 6-h period. The lowest achieved osmolality was 28 mOsm/kg. Polyuria disorders have produced abnormally low urine osmolalities (lowest reported 18 mOsm/kg) but osmolalities < or = 23 mOsm/kg have resulted in death from water intoxication. An osmolality substitution cut-off to delineate a specimen as inconsistent with normal human urine can be set at some value < 50 mOsm/kg, when used in a population of individuals with urine creatinine concentrations < or = 5.0 mg/dL.

  14. Call to action: continuum of care for females of reproductive age to prevent obesity and ensure better health outcomes of offspring through nutrition.

    PubMed

    Zive, Michelle M; Rhee, Kyung E

    2014-09-01

    The health and nutritional status of women of reproductive age has tremendous impact on the health of future populations; therefore, special attention should be paid to promoting women's health, especially a healthy weight at this critical time period. The purpose of the paper is to provide information on the nutritional needs of women at various stages of the reproductive age spectrum, including preconception/interconception and during pregnancy to achieve and maintain a healthy weight. The Socio-Ecological Model (SEM) is presented to help practitioners understand the importance of intervening where women of reproductive age live, work, and frequent.

  15. Myocardial antioxidant status and oxidative stress after combined action of exercise training and ethanol in two different age groups of male albino rats.

    PubMed

    Pushpalatha, K; Nishanth, K; Sathyavelu Reddy, K

    2007-06-01

    The interaction of exercise training and ethanol on the myocardial antioxidant enzymes and the oxidative stress markers was investigated in the Wistar strain male albino rats. We also tested the interactive effects of exercise training and ethanol on the age-associated free radical production and antioxidant defense system. We found a significant decrease (p<0.05) in the activity levels of superoxide dismutase (SOD) and catalase (CAT) in the myocardium of old rats when compared to young rats by 26% and 58%, respectively, suggesting the onset of age-dependent decrease in the myocardial antioxidant enzyme system. In contrast to the decreased antioxidant enzyme activity, xanthine oxidase (XOD) and lipid peroxidation (LPO) levels were elevated, suggesting the age-induced oxidative stress. Exercise training significantly (p < 0.05) elevated the activities of SOD, CAT, XOD and LPO levels in both the age groups of animals. Ethanol consumption significantly lowered the SOD and CAT activities in both the age groups, whereas a significant increase was observed in the XOD and LPO levels. In contrast, the combination of exercise training plus ethanol lowered XOD and LPO levels in both the age groups of rats compared to ethanol treated rats. A significant (p < 0.05) increase in the activities of SOD and CAT was reported in the rats treated with the combination of exercise training plus ethanol. This increase was more pronounced in the younger rats than the older rats. The findings of the present investigation on the potential role of antioxidant enzymes to counter the ethanol-induced pro-oxidants showed an increase with the interaction of exercise training. With age, a decrease in the antioxidant enzyme capacity was observed. This reveals that the old age rats were more affected to the pro-oxidants when compared to the young age rats. In conclusion it is demonstrated that two months treadmill endurance exercise training is beneficial to both young and old rats in improving

  16. Improved Mitochondrial Function in Brain Aging and Alzheimer Disease – the New Mechanism of Action of the Old Metabolic Enhancer Piracetam

    PubMed Central

    Leuner, Kristina; Kurz, Christopher; Guidetti, Giorgio; Orgogozo, Jean-Marc; Müller, Walter E.

    2010-01-01

    Piracetam, the prototype of the so-called nootropic drugs’ is used since many years in different countries to treat cognitive impairment in aging and dementia. Findings that piracetam enhances fluidity of brain mitochondrial membranes led to the hypothesis that piracetam might improve mitochondrial function, e.g., might enhance ATP synthesis. This assumption has recently been supported by a number of observations showing enhanced mitochondrial membrane potential, enhanced ATP production, and reduced sensitivity for apoptosis in a variety of cell and animal models for aging and Alzheimer disease. As a specific consequence, substantial evidence for elevated neuronal plasticity as a specific effect of piracetam has emerged. Taken together, this new findings can explain many of the therapeutic effects of piracetam on cognition in aging and dementia as well as different situations of brain dysfunctions. PMID:20877425

  17. Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

    PubMed

    Yukata, Kiminori; Xie, Chao; Li, Tian-Fang; Takahata, Masahiko; Hoak, Donna; Kondabolu, Sirish; Zhang, Xinping; Awad, Hani A; Schwarz, Edward M; Beck, Christopher A; Jonason, Jennifer H; O'Keefe, Regis J

    2014-05-01

    A stabilized tibia fracture model was used in young (8-week old) and aged (1-year old) mice to define the relative bone regenerative potential and the relative responsiveness of the periosteal progenitor population with aging and PTH 1-34 (PTH) systemic therapy. Bone regeneration was assessed through gene expressions, radiographic imaging, histology/histomorphometry, and biomechanical testing. Radiographs and microCT showed increased calcified callus tissue and enhanced bone healing in young compared to aged mice. A key mechanism involved reduced proliferation, expansion, and differentiation of periosteal progenitor cell populations in aged mice. The experiments showed that PTH increased calcified callus tissue and torsional strength with a greater response in young mice. Histology and quantitative histomorphometry confirmed that PTH increased callus tissue area due primarily to an increase in bone formation, since minimal changes in cartilage and mesenchyme tissue area occurred. Periosteum examined at 3, 5, and 7 days showed that PTH increased cyclin D1 expression, the total number of cells in the periosteum, and width of the periosteal regenerative tissue. Gene expression showed that aging delayed differentiation of both bone and cartilage tissues during fracture healing. PTH resulted in sustained Col10a1 expression consistent with delayed chondrocyte maturation, but otherwise minimally altered cartilage gene expression. In contrast, PTH 1-34 stimulated expression of Runx2 and Osterix, but resulted in reduced Osteocalcin. β-Catenin staining was present in mesenchymal chondroprogenitors and chondrocytes in early fracture healing, but was most intense in osteoblastic cells at later times. PTH increased active β-catenin staining in the osteoblast populations of both young and aged mice, but had a lesser effect in cartilage. Altogether the findings show that reduced fracture healing in aging involves decreased proliferation and differentiation of stem cells lining

  18. Action physics

    NASA Astrophysics Data System (ADS)

    McGinness, Lachlan P.; Savage, C. M.

    2016-09-01

    More than a decade ago, Edwin Taylor issued a "call to action" that presented the case for basing introductory university mechanics teaching around the principle of stationary action [E. F. Taylor, Am. J. Phys. 71, 423-425 (2003)]. We report on our response to that call in the form of an investigation of the teaching and learning of the stationary action formulation of physics in a first-year university course. Our action physics instruction proceeded from the many-paths approach to quantum physics to ray optics, classical mechanics, and relativity. Despite the challenges presented by action physics, students reported it to be accessible, interesting, motivational, and valuable.

  19. Knowing Minds, Controlling Actions: The Developmental Relations between Theory of Mind and Executive Function from 2 to 4 Years of Age

    ERIC Educational Resources Information Center

    Muller, Ulrich; Liebermann-Finestone, Dana P.; Carpendale, Jeremy I. M.; Hammond, Stuart I.; Bibok, Maximilian B.

    2012-01-01

    This longitudinal study examined the concurrent and predictive relations between executive function (EF) and theory of mind (ToM) in 82 preschoolers who were assessed when they were 2, 3, and 4 years old. The results showed that the concurrent relation between EF and ToM, after controlling for age, verbal ability, and sex, was significant at 3 and…

  20. Complementary actions.

    PubMed

    Sartori, Luisa; Betti, Sonia

    2015-01-01

    Complementary colors are color pairs which, when combined in the right proportions, produce white or black. Complementary actions refer here to forms of social interaction wherein individuals adapt their joint actions according to a common aim. Notably, complementary actions are incongruent actions. But being incongruent is not sufficient to be complementary (i.e., to complete the action of another person). Successful complementary interactions are founded on the abilities: (i) to simulate another person's movements, (ii) to predict another person's future action/s, (iii) to produce an appropriate incongruent response which differ, while interacting, with observed ones, and (iv) to complete the social interaction by integrating the predicted effects of one's own action with those of another person. This definition clearly alludes to the functional importance of complementary actions in the perception-action cycle and prompts us to scrutinize what is taking place behind the scenes. Preliminary data on this topic have been provided by recent cutting-edge studies utilizing different research methods. This mini-review aims to provide an up-to-date overview of the processes and the specific activations underlying complementary actions.

  1. Complementary actions

    PubMed Central

    Sartori, Luisa; Betti, Sonia

    2015-01-01

    Complementary colors are color pairs which, when combined in the right proportions, produce white or black. Complementary actions refer here to forms of social interaction wherein individuals adapt their joint actions according to a common aim. Notably, complementary actions are incongruent actions. But being incongruent is not sufficient to be complementary (i.e., to complete the action of another person). Successful complementary interactions are founded on the abilities: (i) to simulate another person’s movements, (ii) to predict another person’s future action/s, (iii) to produce an appropriate incongruent response which differ, while interacting, with observed ones, and (iv) to complete the social interaction by integrating the predicted effects of one’s own action with those of another person. This definition clearly alludes to the functional importance of complementary actions in the perception–action cycle and prompts us to scrutinize what is taking place behind the scenes. Preliminary data on this topic have been provided by recent cutting-edge studies utilizing different research methods. This mini-review aims to provide an up-to-date overview of the processes and the specific activations underlying complementary actions. PMID:25983717

  2. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh.

    This affirmative action (AA) guide is intended to identify and remove discriminatory employment practices that may still exist in the North Carolina State Department of Public Instruction (DPI). DPI extends equal employment opportunity (EEO) to all applicants and employees without regard to race, color, religion, sex, age, handicap, political…

  3. Action Learning.

    ERIC Educational Resources Information Center

    1996

    These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings…

  4. Sex differences in insulin action and body fat distribution in overweight and obese middle-aged and older men and women.

    PubMed

    Ferrara, Cynthia M; Goldberg, Andrew P; Nicklas, Barbara J; Sorkin, John D; Ryan, Alice S

    2008-08-01

    Controversy exists as to whether there are differences in insulin action between older men and women, and what factors contribute to these differences. This study tests the hypothesis that sex differences in regional fat distribution contribute to a disparity in insulin sensitivity in older men vs. older women. Healthy, older (50-71 years), sedentary men (n = 28) and women (n = 29) were recruited to participate in the study. Body fat, fat-free mass (FFM), and visceral (VAT) and subcutaneous abdominal (SAT) adipose tissue areas were measured by DXA and computed tomography (CT). For measurements of insulin-stimulated glucose disposal (M), insulin was infused at a constant rate of 240 pmol.m(-2).min(-1), and M was calculated between the 90th and 120th min of the hyperinsulinemic-euglycemic clamp. The men weighed 16% more and had 16% higher waist and 4% lower hip circumferences than women (p < 0.05 for all). Total fat mass and SAT were 21% and 33% lower and FFM was 49% higher in men than in women, whereas waist-to-hip ratio (WHR) and VAT:SAT ratio were 21% and 56% higher in men than in women (p < 0.05 for all). Although insulin concentrations during the glucose clamp were higher in men, M was 47% lower in men vs. women (21.7 +/- 1.1 vs. 46.7 +/- 3.1 micromol.L(-1).kg FFM(-1).min(-1), p < 0.05). The sex-related differences in M persisted after controlling for insulin concentrations during the glucose clamp, for waist, WHR, and VAT:SAT. Older men are more insulin resistant than women, despite lower body fat and subcutaneous abdominal fat. This difference in insulin sensitivity is not explained by abdominal fat distribution, therefore other metabolic factors contribute to the sex differences in insulin sensitivity.

  5. Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis.

    PubMed

    Argüelles, Sandro; Cano, Mercedes; Machado, Alberto; Ayala, Antonio

    2011-01-01

    The hypothalamic-hypophysis system (HHS) secretes peptide hormones whose synthesis requires the integrity of the translation machinery. As the organisms age, a considerable diminution of the protein synthesis takes place in several tissues. Among the possible causes of the decline of translation in old animals are the modifications of elongation factor-2 (eEF-2). We studied whether the level of this protein was affected in the HHS in old animals. The effects of aging are compared to those of an oxidant compound (cumene hydroperoxide) administered to young rats. The results indicate that oxidative stress could be involved in the alterations of eEF-2, which forms adducts with malondialdehyde (MDA) and 4-hydroxynonenal (HNE). The alterations of eEF-2 levels, secondary to lipid peroxidation and adduct formation with these aldehydes could contribute to the suboptimal hormone production from these tissues during aging. Besides eEF-2, proteomic analysis shows that several other proteins are affected.

  6. Listing of color additives for coloring sutures; [phthalocyaninato(2-)] copper. Food and Drug Administration, HHS. Final rule.

    PubMed

    1999-04-30

    The Food and Drug Administration (FDA) is amending the color additive regulations to provide for the safe use of [phthalocyaninato(2-)] copper in coloring nonabsorbable sutures for general and ophthalmic surgery made from a blend of poly(vinylidene fluoride) and poly(vinylidene fluoride-co-hexafluoropropylene). This action responds to a petition filed by Ethicon, Inc.

  7. A Difference-in-Differences Approach to Assess the Effect of a Heat Action Plan on Heat-Related Mortality, and Differences in Effectiveness According to Sex, Age, and Socioeconomic Status (Montreal, Quebec)

    PubMed Central

    Benmarhnia, Tarik; Bailey, Zinzi; Kaiser, David; Auger, Nathalie; King, Nicholas; Kaufman, Jay S.

    2016-01-01

    Background: The impact of heat waves on mortality and health inequalities is well documented. Very few studies have assessed the effectiveness of heat action plans (HAPs) on health, and none has used quasi-experimental methods to estimate causal effects of such programs. Objectives: We developed a quasi-experimental method to estimate the causal effects associated with HAPs that allows the identification of heterogeneity across subpopulations, and to apply this method specifically to the case of the Montreal (Quebec, Canada) HAP. Methods: A difference-in-differences approach was undertaken using Montreal death registry data for the summers of 2000–2007 to assess the effectiveness of the Montreal HAP, implemented in 2004, on mortality. To study equity in the effect of HAP implementation, we assessed whether the program effects were heterogeneous across sex (male vs. female), age (≥ 65 years vs. < 65 years), and neighborhood education levels (first vs. third tertile). We conducted sensitivity analyses to assess the validity of the estimated causal effect of the HAP program. Results: We found evidence that the HAP contributed to reducing mortality on hot days, and that the mortality reduction attributable to the program was greater for elderly people and people living in low-education neighborhoods. Conclusion: These findings show promise for programs aimed at reducing the impact of extreme temperatures and health inequities. We propose a new quasi-experimental approach that can be easily applied to evaluate the impact of any program or intervention triggered when daily thresholds are reached. Citation: Benmarhnia T, Bailey Z, Kaiser D, Auger N, King N, Kaufman J. 2016. A difference-in-differences approach to assess the effect of a heat action plan on heat-related mortality, and differences in effectiveness according to sex, age, and socioeconomic status (Montreal, Quebec). Environ Health Perspect 124:1694–1699; http://dx.doi.org/10.1289/EHP203 PMID:27203433

  8. Action perception predicts action performance

    PubMed Central

    Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.

    2013-01-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113

  9. Action perception predicts action performance.

    PubMed

    Bailey, Heather R; Kurby, Christopher A; Giovannetti, Tania; Zacks, Jeffrey M

    2013-09-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system.

  10. Medical devices; exemption from premarket notification and reserved devices; class I. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-01-14

    The Food and Drug Administration (FDA) is amending its classification regulations to designate class I devices that are exempt from the premarket notification requirements, subject to certain limitations, and to designate those class I devices that remain subject to premarket notification requirements under the new statutory criteria for premarket notification requirements. The devices FDA is designating as exempt do not include class I devices that have been previously exempted by regulation from the premarket notification requirements. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the 1976 amendments), the Safe Medical Devices Act of 1990 (SMDA), and the FDA Modernization Act of 1997 (FDAMA). FDA is taking this action in order to implement a requirement of FDAMA. Elsewhere in this issue of the Federal Register, FDA is announcing that it is withdrawing proposed rules to revoke existing exemptions from premarket notification for two devices.

  11. Opioid abuse in the United States and Department of Health and Human Services actions to address opioid-drug-related overdoses and deaths.

    PubMed

    U S Department Of Health And Human Services

    2015-06-01

    On March 26, 2015, the Office of the Assistant Secretary for Planning and Evaluation of the U.S. Department of Health and Human Services (HSS) published an online Issue Brief that addresses opioid abuse in the United States and (HHS) actions to address opioid-drug-related overdoses and deaths. This report, which contains the full content of the Issue Brief, is adapted from that document.

  12. Health care programs: fraud and abuse; revisions to the civil money penalty provisions relating to the misuse of certain names, symbols and emblems--HHS. Final rule.

    PubMed

    1995-11-27

    In accordance with amendments to section 1140 of the Social Security Act, resulting from the Social Security Independence and Program Improvements Act of 1994, this final rule makes a number of revisions to the civil money penalty authority regulations relating to the misuse of certain symbols, emblems and names. Among other revisions, this rule eliminates the annual cap on penalties, includes the words and letters of the Department and Medicaid under the prohibition, and redefines a violation with regard to mailings. In addition, this final rule serves to remove references to Social Security and the Social Security Administration (SSA) from the HHS/OIG penalty regulations. The penalty regulations addressing the misuse of certain words, letters, symbols and emblems for SSA and its programs are being set forth in a new part of the Code of Federal Regulations published elsewhere in this edition of the Federal Register.

  13. Revocation of Office of Generic Drug's interim policy statement on inactive ingredients. Food and Drug Administration, HHS. Notice.

    PubMed

    1999-04-30

    The Food and Drug Administration (FDA) is revoking an interim policy statement on inactive ingredients in parenteral, ophthalmic, otic, and topical generic drug products (Interim Inactive Ingredient Policy). These generic drug products are the subjects of abbreviated new drug applications (ANDA's). The Interim Inactive Ingredient Policy was issued as a memorandum from the Acting Director of the Center for Drug Evaluation and Research's (CDER's) Office of Generic Drugs, FDA, to CDER's Associate Director for Science and Medical Affairs, FDA. FDA is taking this action because the Interim Inactive Ingredient Policy no longer represents current agency policy.

  14. Estimating the Age of the Hawaiian Hotspot

    NASA Astrophysics Data System (ADS)

    Scholl, D. W.; Rea, D. K.

    2002-12-01

    INTRODUCTION: West of the Hawaii hotspot (HHS), an age-progressing chain of seamounts extends northwestwardly ~3600 km to the Hawaii-Emperor bend, beyond which the chain continues for ~2200 km as the north-northwestwardly trending Emperor Ridge. The ridge terminates at the ~82-Myr-old Meiji Seamount, which is perched atop the outer slope of the Kuril-Kamchatka Trench. West of Meiji, at Cape Kronotsky, the ridge orthogonally disappears into the Kamchatka subduction zone. If the length of the subducted sector of the Emperor Ridge could be estimated, then the age when volcanism began above the HHS could be estimated. MEIJI DRIFT: Deposition of the Meiji drift deposits along the northern side of the far northern or Meiji-Detroit sector of the Emperor Ridge provides a way to estimate the minimum age of the HHS. The drift deposit (as thick as 1800 m) began to accumulate about 33.5 Ma (earliest Oligocene) during the Earth's climatic transition to the ice house world. South-bound abyssal currents exiting the Bering Sea Basin, possibly generated there by thermohaline circulation, deposited the drift along the ridge sector. At this time, the sector receiving drift deposits was positioned at least 2200 km SE of its present Kamchatka trench location. Also at this time, the Aleutian Ridge (arc) cordoning the Bering Sea from the north Pacific was at least 1000 km shorter than its present length, which has been greatly lengthened during the past 50 Myr by plate boundary, transform faulting. Thus, in the early Oligocene, a wide western seaway connected abyssal circulation between the Bering Sea and north Pacific Basins. MINIMUM AGE ESTIMATING: Initiation of drift deposition requires that a former continuation of the Meiji-Detroit seamount sector, referred to here as the Obruchev continuation, crossed the north Pacific and forced abyssal currents arriving from the Bering Sea to flow eastward along the continuation's northern flank. To deflect south-bound abyssal currents, the

  15. Citizen's actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The role played by individual citizens as consumers of energy was examined, with emphasis on studying ways in which their action could result in energy conservation. It was shown that there are ways that energy can be conserved in this way, with citizens acting either individually or in groups. The potential savings are significant, but the actual savings may be quite small. The citizens need to be motivated to save and to believe in a conservation ethic; developing such an ethic is difficult, and perhaps not responsive to the shotgun approach now being attempted. The true course of action may be to synthesize new societal structures that provide the maximum evolution of culture within the limitation of scarce energy resources.

  16. Correlates of hot day air-conditioning use among middle-aged and older adults with chronic heart and lung diseases: the role of health beliefs and cues to action.

    PubMed

    Richard, Lucie; Kosatsky, Tom; Renouf, Annie

    2011-02-01

    Extreme ambient heat is a serious public health threat, especially for the elderly and persons with pre-existing health conditions. Although much of the excess mortality and morbidity associated with extreme heat is preventable, the adoption of effective preventive strategies is limited. The study reported here tested the predictive power of selected components of the Health Belief Model for air-conditioning (AC) use among 238 non-institutionalized middle-aged and older adults with chronic heart failure and/or chronic obstructive pulmonary disease living in Montréal, Canada. Respondents were recruited through clinics (response rate 71%) and interviews were conducted in their homes or by telephone. Results showed that 73% of participants reported having a home air conditioner. The average number of hours spent per 24-hour period in air-conditioned spaces during heat waves was 14.5 hours (SD = 9.4). Exploratory structural equation modeling showed that specific beliefs about the benefits of and drawbacks to AC as well as internal cues to action were predictive of its level of use, whereas the perceived severity of the effects of heat on health was not. The findings are discussed in light of the need to adequately support effective response to extreme heat in this vulnerable population.

  17. Conscious Action/Zombie Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    Abstract I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co‐conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do. PMID:27667859

  18. Conscious Action/Zombie Action.

    PubMed

    Shepherd, Joshua

    2016-06-01

    I argue that the neural realizers of experiences of trying (that is, experiences of directing effort towards the satisfaction of an intention) are not distinct from the neural realizers of actual trying (that is, actual effort directed towards the satisfaction of an intention). I then ask how experiences of trying might relate to the perceptual experiences one has while acting. First, I assess recent zombie action arguments regarding conscious visual experience, and I argue that contrary to what some have claimed, conscious visual experience plays a causal role for action control in some circumstances. Second, I propose a multimodal account of the experience of acting. According to this account, the experience of acting is (at the very least) a temporally extended, co-conscious collection of agentive and perceptual experiences, functionally integrated and structured both by multimodal perceptual processing as well as by what an agent is, at the time, trying to do.

  19. Action Learning: Avoiding Conflict or Enabling Action

    ERIC Educational Resources Information Center

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  20. Exemption of certain research and demonstration projects from regulations for protection of human research subjects--Office of the Secretary, HHS. Final rule.

    PubMed

    1983-03-04

    The Department of Health and Human Services (the Department or HHS) is including among the types of research specifically exempt from the application of the regulatory requirements of 45 CFR Part 46 (protection of human research subjects) research and demonstration projects conducted under the Social Security Act and other federal statutory authority and designed to study certain public benefit or service programs, the procedures for obtaining benefits or services under those programs, and possible changes or alternatives to those programs or procedures, including changes in methods or levels of payment. These demonstration and service projects are already subject to procedures which provide for extensive review by high level officials in various program administration offices. Review by an Institutional Review Board (IRB), as required under Part 46, would be duplicative and burdensome to state and local agencies and to other entities participating in demonstration projects. Removal of this unnecessary layer of review will not only reduce the cost of the projects but help to avoid unnecessary delays in project implementation. However, in order to ensure the continued protection of human subjects participating in such research activity, the Department is adding a specific requirement of written, informed consent in any instance, not reviewed by an IRB, in which the Secretary determines that the research activity presents a danger to the physical, mental or emotional well-being of a participant.

  1. Gestational age

    MedlinePlus

    Fetal age - gestational age; Gestation; Neonatal gestational age; Newborn gestational age ... Gestational age can be determined before or after birth. Before birth, your health care provider will use ultrasound to ...

  2. Aging Skin

    MedlinePlus

    ... email address Submit Home > Healthy Aging > Wellness Healthy Aging Aging skin More information on aging skin When it ... treated early. Return to top More information on Aging skin Read more from womenshealth.gov Varicose Veins ...

  3. [Nutrition, aging, old age].

    PubMed

    Iván, L

    1998-12-06

    In humans there is evidence that the restriction of total caloric intake appears to be more important than the restriction of any particular macronutrient. Today the mechanism of the effect of caloric restriction is unknown. With advancing age and the occurrence of concomitant illness there is an increased risk of developing nutritional deficiencies. Altered nutritional status is associated with the pathogenesis of a number of common diseases of the elderly, thus it would appear that nutritional modulation and manipulation represents one possible approach to successful aging and a healthy longevity. The conceptual framework of the paper suggests the need of a newer light of the aging processes namely by a holistic human-gero-ecological model and a personality oriented geriatry. There are accentuated the role of the nutrients and vitamins, the food intake and drug-nutrients interactions and the meanings of the differences between the normal and pathological aging.

  4. Protective Action Guides (PAGs)

    EPA Pesticide Factsheets

    The Protective Action Guide (PAG) manual contains radiation dose guidelines that would trigger public safety measures. EPA developed Protective Action Guides to help responders plan for radiation emergencies.

  5. 42 CFR 93.500 - General policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General... findings of research misconduct and HHS administrative actions, including debarment or suspension, arising... to contest ORI research misconduct findings and HHS administrative actions under this part,...

  6. 42 CFR 93.500 - General policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General... findings of research misconduct and HHS administrative actions, including debarment or suspension, arising... to contest ORI research misconduct findings and HHS administrative actions under this part,...

  7. Less chalk more action

    NASA Astrophysics Data System (ADS)

    Mitriceski Andelkovic, Bojana; Jovic, Sladjana

    2016-04-01

    Less chalk more action Education should not be a mechanical system that operates according to the principles of the orders and implementation. Education should respect the basic laws of the develop and progress. Curiosity is the engine of achievement and children spontaneously and happily learn only if they get interested, if teacher wake up and stimulate their creativity and individuality. We would like to present classes that are realized as thematic teaching with several subjects involved: chemistry, geography, math, art and biology. Classes were organized for students at age from 10 to 13 years, every month during autumn and winter 2015. Better students identified themselves as teachers and presented peer education .Teachers were monitoring the process of teaching and help to develop links between younger and older students, where older students were educators to younger students. Also one student with special needs was involved in this activities and was supported by other students during the workshops The benefit from this project will be represented with evaluation marks. Evaluation table shows that group of ten students(age 10 to13 years) which are selected in October as children with lack of motivation for learning, got better marks, at the end of January , then they had it in the beginning of the semester.

  8. Action Research: Rethinking Lewin.

    ERIC Educational Resources Information Center

    Dickens, Linda; Watkins, Karen

    1999-01-01

    Explores both historical and contemporary definitions of action research. Describes the process and goals of action research in the tradition of Lewin. Presents a case study of an action-research project involving two teams in a high-technology corporation that depicts the process in action. (Author/CCM)

  9. Inferences about Action Engage Action Systems

    ERIC Educational Resources Information Center

    Taylor, Lawrence J.; Lev-Ari, Shiri; Zwaan, Rolf A.

    2008-01-01

    Verbal descriptions of actions activate compatible motor responses [Glenberg, A. M., & Kaschak, M. P. (2002). Grounding language in action. "Psychonomic Bulletin & Review, 9", 558-565]. Previous studies have found that the motor processes for manual rotation are engaged in a direction-specific manner when a verb disambiguates the direction of…

  10. Healthy Aging

    MedlinePlus

    ... About Us Contact Us Text size | Print | Healthy Aging This information in Spanish ( en español ) A healthy ... Aging email updates. Enter email address Submit Healthy Aging news Accessibility | Privacy policy | Disclaimers | FOIA | Link to ...

  11. Set Goals & Select Actions

    EPA Pesticide Factsheets

    This phase of the Local Climate Action Framework will help users articulate the goals for their climate, energy, and sustainability programs, as well as to identify the actions that are most appropriate to help meet those goals.

  12. American Lead Action Memorandum

    EPA Pesticide Factsheets

    ACTION MEMORANDUM— Request for a Time-Critical Removal Action andExemption from the $2 Million and 12-Month Statutory Limits at the AmericanLead Site, Indianapolis, Marion County, Indiana (Site ID #B56J)

  13. Disorders of androgen action.

    PubMed

    Sultan, Charles; Lumbroso, Serge; Paris, Françoise; Jeandel, Claire; Terouanne, B; Belon, Charles; Audran, F; Poujol, N; Georget, V; Gobinet, J; Jalaguier, S; Auzou, G; Nicolas, J C

    2002-08-01

    Disorders of androgen action are the main cause of male pseudohermaphroditism and include 5alphaR deficiency and androgen receptor defects. 5alphaR deficiency is characterized by female genitalia with some degree of masculinization, clitoromegaly, and severely bifid scrotum corresponding to the so-called pseudovaginal perineoscrotal hypospadias. At the onset of puberty, increased muscle mass, development of pubic hair, and phallic growth are associated with the acquisition of male gender identity. Normal or increased levels of testosterone and an elevated testosterone-to-dihydrotestosterone ratio after human chorionic gonadotropin stimulation testing suggest 5alphareductase deficiency, and the diagnosis can be ascertained by identifying the mutation in the 5alphaR-2 gene. Whatever the patient's age at diagnosis, psychological evaluation with 5alphaRD is vital. Androgen receptor defects encompass two clinical expressions: the complete and partial androgen insensitivity syndromes. Complete androgen insensitivity syndrome should be suspected at birth in the presence of inguinal hernia in a girl without genital ambiguity. At puberty, the sign of alert is primary amenorrhea with normal female phenotype and harmonious mammary development but no pubic hair growth. Partial androgen insensitivity syndrome covers a wide spectrum of undervirilized phenotypes ranging from clitoromegaly at birth to infertile men. In all cases, complementary investigations should include plasma testosterone and luteinizing hormone as well as androgen-binding capacity in cultured genital skin fibroblasts. Diagnosis is confirmed by identification of the androgen receptor gene mutation. Although patients with complete androgen insensitivity syndrome are raised as females, patients with partial androgen insensitivity syndrome should be managed according to age at diagnosis, response to treatment with exogenous androgens, and the presence of an androgen gene mutation. Gonadectomy in complete androgen

  14. Action in Development

    ERIC Educational Resources Information Center

    von Hofsten, Claes

    2007-01-01

    It is argued that cognitive development has to be understood in the functional perspective provided by actions. Actions reflect all aspects of cognitive development including the motives of the child, the problems to be solved, and the constraints and possibilities of the child's body and sensorimotor system. Actions are directed into the future…

  15. Putting Action in Perspective

    ERIC Educational Resources Information Center

    Lozano, Sandra C.; Hard, Bridgette Martin; Tversky, Barbara

    2007-01-01

    Embodied approaches to cognition propose that our own actions influence our understanding of the world. Do other people's actions also have this influence? The present studies show that perceiving another person's actions changes the way people think about objects in a scene. In Study 1, participants viewed a photograph and answered a question…

  16. Action Learning at Work.

    ERIC Educational Resources Information Center

    Mumford, Alan, Ed.

    This book contains 34 papers examining the theory, process, and outcomes of action learning at work. The following papers are included: "An Introduction to the Text" (Alan Mumford); "The Learning Equation" (Reg Revans); "Action Learning as a Vehicle for Learning" (Alan Mumford); "Placing Action Learning and…

  17. Conservation Action Handbook.

    ERIC Educational Resources Information Center

    National Rifle Association, Washington, DC.

    Conservation problems are identified, with some suggestions for action. General areas covered are: Wildlife Conservation, Soil Conservation, Clean Water, Air Pollution Action, and Outdoor Recreation Action. Appendices list private organizations or agencies concerned with natural resource use and/or management, congressional committees considering…

  18. Planning as Action Research

    ERIC Educational Resources Information Center

    de Gonzalez, Carmen Beatriz; Hernandez, Teresa; Kusch, Jim; Ryan, Charly

    2004-01-01

    Planning contains so much more than the written plan. Early in 2000, an invitation came from the Collaborative Action Research Network (CARN), to people experienced in action research who might want to help plan and present an action research event for elementary school science teachers in Venezuela, South America, in Autumn 2000. This article…

  19. Participatory Action Research.

    ERIC Educational Resources Information Center

    Walker, Martha Lentz

    1993-01-01

    Describes aspects of participatory action research and considers advantages of using participatory action research in research by disabilities and rehabilitation researchers. Notes that participatory action research can be built into any rehabilitation research design but that it rests upon the recognition of persons with disabilities as integral…

  20. Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project.

    PubMed

    Calderon, M A; Demoly, P; Casale, T; Akdis, C A; Bachert, C; Bewick, M; Bilò, B M; Bohle, B; Bonini, S; Bush, A; Caimmi, D P; Canonica, G W; Cardona, V; Chiriac, A M; Cox, L; Custovic, A; De Blay, F; Devillier, P; Didier, A; Di Lorenzo, G; Du Toit, G; Durham, S R; Eng, P; Fiocchi, A; Fox, A T; van Wijk, R Gerth; Gomez, R M; Haathela, T; Halken, S; Hellings, P W; Jacobsen, L; Just, J; Tanno, L K; Kleine-Tebbe, J; Klimek, L; Knol, E F; Kuna, P; Larenas-Linnemann, D E; Linneberg, A; Matricardi, M; Malling, H J; Moesges, R; Mullol, J; Muraro, A; Papadopoulos, N; Passalacqua, G; Pastorello, E; Pfaar, O; Price, D; Del Rio, P Rodriguez; Ruëff, R; Samolinski, B; Scadding, G K; Senti, G; Shamji, M H; Sheikh, A; Sisul, J C; Sole, D; Sturm, G J; Tabar, A; Van Ree, R; Ventura, M T; Vidal, C; Varga, E M; Worm, M; Zuberbier, T; Bousquet, J

    2016-01-01

    Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

  1. Mechanisms underlying selecting objects for action

    PubMed Central

    Wulff, Melanie; Laverick, Rosanna; Humphreys, Glyn W.; Wing, Alan M.; Rotshtein, Pia

    2015-01-01

    We assessed the factors which affect the selection of objects for action, focusing on the role of action knowledge and its modulation by distracters. Fourteen neuropsychological patients and 10 healthy aged-matched controls selected pairs of objects commonly used together among distracters in two contexts: with real objects and with pictures of the same objects presented sequentially on a computer screen. Across both tasks, semantically related distracters led to slower responses and more errors than unrelated distracters and the object actively used for action was selected prior to the object that would be passively held during the action. We identified a sub-group of patients (N = 6) whose accuracy was 2SDs below the controls performances in the real object task. Interestingly, these impaired patients were more affected by the presence of unrelated distracters during both tasks than intact patients and healthy controls. Note that the impaired patients had lesions to left parietal, right anterior temporal and bilateral pre-motor regions. We conclude that: (1) motor procedures guide object selection for action, (2) semantic knowledge affects action-based selection, (3) impaired action decision making is associated with the inability to ignore distracting information and (4) lesions to either the dorsal or ventral visual stream can lead to deficits in making action decisions. Overall, the data indicate that impairments in everyday tasks can be evaluated using a simulated computer task. The implications for rehabilitation are discussed. PMID:25954177

  2. National Biofuels Action Plan

    DTIC Science & Technology

    2008-10-01

    Leading the Federal Interagency Biomass Research and Development Initiative October 2008 National Biofuels Action Plan Biomass Research and...REPORT DATE OCT 2008 2. REPORT TYPE 3. DATES COVERED 00-00-2008 to 00-00-2008 4. TITLE AND SUBTITLE National Biofuels Action Plan 5a. CONTRACT...goal of the National Biofuels Action Plan is to maximize the environmental and economic benefi ts of biofuels use by advancing sustainable practices

  3. Stereoscopically Observing Manipulative Actions

    PubMed Central

    Ferri, S.; Pauwels, K.; Rizzolatti, G.; Orban, G. A.

    2016-01-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors “stimulus type” (action, static control, and dynamic control), “stereopsis” (present, absent) and “viewpoint” (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  4. Action principles in nature

    NASA Astrophysics Data System (ADS)

    Barrow, John D.; Tipler, Frank J.

    1988-01-01

    Physical theories have their most fundamental expression as action integrals. This suggests that the total action of the universe is the most fundamental physical quantity, and hence finite. In this article it is argued that finite universal action implies that the universe is spatially closed. Further, the possible spatial topologies, the types of matter that can dominate the early universe dynamics, and the form of any quadratic additions to the lagrangian of general relativity are constrained. Initial and final cosmological curvature singularities are required to avoid a universal action singularity.

  5. Skin Aging

    MedlinePlus

    Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it ... heal, too. Sunlight is a major cause of skin aging. You can protect yourself by staying out ...

  6. Exemption from federal preemption of state and local cigarette and smokeless tobacco requirements; revocation. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-11-07

    The Food and Drug Administration (FDA) is revoking its regulation governing the exemption from Federal preemption of State and local medical device requirements for the sale and distribution of cigarettes and smokeless tobacco to children and adolescents. This action is being taken in response to the Supreme Court Decision of March 21, 2000, in which the court held that Congress has not given FDA the authority to regulate tobacco products as customarily marketed. On March 31, 2000, FDA removed its regulations restricting the sale and distribution of cigarettes and smokeless tobacco to children and adolescents. Because these regulations are not in effect, the State requirements are not preempted. Therefore, FDA is revoking its regulations exempting the State and local requirements from preemption. This rule is also adding a regulation that was inadvertently removed in a previous document.

  7. Age Limits.

    PubMed

    Antfolk, Jan

    2017-03-01

    Whereas women of all ages prefer slightly older sexual partners, men-regardless of their age-have a preference for women in their 20s. Earlier research has suggested that this difference between the sexes' age preferences is resolved according to women's preferences. This research has not, however, sufficiently considered that the age range of considered partners might change over the life span. Here we investigated the age limits (youngest and oldest) of considered and actual sex partners in a population-based sample of 2,655 adults (aged 18-50 years). Over the investigated age span, women reported a narrower age range than men and women tended to prefer slightly older men. We also show that men's age range widens as they get older: While they continue to consider sex with young women, men also consider sex with women their own age or older. Contrary to earlier suggestions, men's sexual activity thus reflects also their own age range, although their potential interest in younger women is not likely converted into sexual activity. Compared to homosexual men, bisexual and heterosexual men were more unlikely to convert young preferences into actual behavior, supporting female-choice theory.

  8. Mosaic aging

    PubMed Central

    Walker, Lary C.; Herndon, James G.

    2010-01-01

    Summary Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer to as mosaic aging. Varying genetic, epigenetic and environmental factors (local and extrinsic) contribute to the aging phenotype in a given individual, and these agents influence the type and rate of functional decline, as well as the likelihood of developing age-associated afflictions such as cardiovascular disease, arthritis, cancer, and neurodegenerative disorders. Identifying key factors that drive aging, clarifying their activities in different systems, and in particular understanding how they interact will enhance our comprehension of the aging process, and could yield insights into the permissive role that senescence plays in the emergence of acute and chronic diseases of the elderly. PMID:20110150

  9. ACTION OF AUXIN ON LEAF ABSCISSION

    DTIC Science & Technology

    Experiments have been conducted to investigate a two-stage effect of auxin on abscission. The two stages were demonstrated on greenhouse-grown Black...the second stage - the stage which is stimulated by auxin . Similar experiments were performed with petioles of various lengths and ages. The...implications of these results indicate possible sites of auxin action on leaf abscission. (Author)

  10. 76 FR 65203 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging ACTION: Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Mechanisms of Osteoporosis II. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  11. Action Learning in China

    ERIC Educational Resources Information Center

    Marquardt, Michael J.

    2015-01-01

    Action learning was introduced into China less than 20 years ago, but has rapidly become a valuable tool for organizations seeking to solve problems, develop their leaders, and become learning organizations. This article provides an historical overview of action learning in China, its cultural underpinnings, and five case studies. It concludes…

  12. Who Needs Affirmative Action.

    ERIC Educational Resources Information Center

    Ginger, Ann Fagan

    1979-01-01

    Affirmative action and reverse discrimination are discussed. Facts that were omitted from the court record on the Bakke case are examined. The need for encouraging minority students and women to continue to press for school admission and for lawyers to continue to press affirmative action suits is stressed. (MC)

  13. Renormalized action improvements

    SciTech Connect

    Zachos, C.

    1984-01-01

    Finite lattice spacing artifacts are suppressed on the renormalized actions. The renormalized action trajectories of SU(N) lattice gauge theories are considered from the standpoint of the Migdal-Kadanoff approximation. The minor renormalized trajectories which involve representations invariant under the center are discussed and quantified. 17 references.

  14. Training for Nonviolent Action.

    ERIC Educational Resources Information Center

    Olson, Theodore W.; Shivers, Lynne

    The theory and practice of nonviolent action training as it exists to date are reviewed in this pamphlet. A response to a renewal of interest in alternative forms of social action, the pamphlet results specifically from an international seminar of experienced organizers and trainers held at Preston Patrick, Westmorland, England, June 27 - July 2,…

  15. Affirmative Action Program Manual.

    ERIC Educational Resources Information Center

    Ventura County Community Coll. District, CA.

    Guidelines relating to the affirmative action program of the Ventura County Community College District are provided in this manual. Affirmative action is defined as, "A set of specific and result-oriented procedures to which a contractor commits himself/herself to apply every good faith effort. The objective of those procedures, plus such efforts,…

  16. 25 Action Learning Schools.

    ERIC Educational Resources Information Center

    National Association of Secondary School Principals, Reston, VA.

    This booklet on action-learning reflects an interest in preparing youth for the world of real experiences. Arranged in two major parts, the first offers information on the background and development of action-learning. Included in this section are the conclusions of the Panel on Youth of the President's Science Advisory Committee, the National…

  17. ACTION. 1977 Annual Report.

    ERIC Educational Resources Information Center

    ACTION, Washington, DC.

    In this report are described projects and activities undertaken by ACTION's volunteer programs in 1977. The first section concentrates on reviews conducted, including a major review of ACTION's domestic volunteer programs and the management systems supporting them and an assessment of its programs using the Zero-Base Budget approach called for by…

  18. Action Learning and Leadership.

    ERIC Educational Resources Information Center

    Marquardt, Michael J.

    2000-01-01

    Today's leaders perform the following roles: systems thinker, change agent, innovator, servant, polychronic coordinator, teacher-mentor, and visionary. The elements of action learning (real problems, teams, reflective inquiry, commitment to action, focus on learning) contribute to the development of these critical skills. (Author/SK)

  19. Handbook for Ecology Action.

    ERIC Educational Resources Information Center

    Eber, Ronald

    This handbook has been compiled to aid concerned individuals and ecology groups more adequately define their goals, initiate good programs, and take effective action. It examines the ways a group of working individuals can become involved in action programs for ecological change. Part 1 deals with organization, preliminary organizing, structuring,…

  20. Conscious Vision in Action.

    PubMed

    Briscoe, Robert; Schwenkler, John

    2015-09-01

    It is natural to assume that the fine-grained and highly accurate spatial information present in visual experience is often used to guide our bodily actions. Yet this assumption has been challenged by proponents of the Two Visual Systems Hypothesis (TVSH), according to which visuomotor programming is the responsibility of a "zombie" processing stream whose sources of bottom-up spatial information are entirely non-conscious (Clark, 2007, 2009; Goodale & Milner, 1992, 2004a; Milner & Goodale, 1995/2006, 2008). In many formulations of TVSH, the role of conscious vision in action is limited to "recognizing objects, selecting targets for action, and determining what kinds of action, broadly speaking, to perform" (Clark, 2007, p. 570). Our aim in this study is to show that the available evidence not only fails to support this dichotomous view but actually reveals a significant role for conscious vision in motor programming, especially for actions that require deliberate attention.

  1. Oxidative stress and ageing.

    PubMed

    Birch-Machin, M A; Bowman, A

    2016-10-01

    Oxidative stress is the resultant damage due to redox imbalances (increase in destructive free radicals [reactive oxygen species (ROS)] and reduction in antioxidant protection/pathways) and is linked to ageing in many tissues including skin. In ageing skin there are bioenergetic differences between keratinocytes and fibroblasts which provide a potential ageing biomarker. The differences in skin bioenergy are part of the mitochondrial theory of ageing which remains one of the most widely accepted ageing theories describing subsequent increasing free radical generation. Mitochondria are the major source of cellular oxidative stress and form part of the vicious cycle theory of ageing. External and internal sources of oxidative stress include UVR/IR, pollution (environment), lifestyle (exercise and diet), alcohol and smoking all of which may potentially impact on skin although many exogenous actives and endogenous antioxidant defence systems have been described to help abrogate the increased stress. This also links to differences in skin cell types in terms of the UVR action spectrum for nuclear and mitochondrial DNA damage (the latter a previously described UVR biomarker in skin). Recent work associates bioenergy production and oxidative stress with pigment production thereby providing another additional potential avenue for targeted anti-ageing intervention in skin. This new data supporting the detrimental effects of the numerous wavelengths of UVR may aid in the development of cosmetic/sunscreen design to reduce the effects of photoageing. Recently, complex II of the mitochondrial electron transport chain appears to be more important than previously thought in the generation of free radicals (suggested predominantly by non-human studies). We investigated the relationship between complex II and ageing using human skin as a model tissue. The rate of complex II activity per unit of mitochondria was determined in fibroblasts and keratinocytes cultured from skin covering

  2. Polyphenols and aging.

    PubMed

    Queen, Brannon L; Tollefsbol, Trygve O

    2010-02-01

    Age-associated changes within an individual are inherently complex and occur at multiple levels of organismal function. The overall decline in function of various tissues is known to play a key role in both aging and the complex etiology of certain age-associated diseases such as Alzheimer's disease (AD) and cancer. Continuing research highlights the dynamic capacity of polyphenols to protect against age-associated disorders through a variety of important mechanisms. Numerous lines of evidence suggest that dietary polyphenols such as resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and curcumin have the capacity to mitigate age-associated cellular damage induced via metabolic production of reactive oxygen species (ROS). However, recently acquired evidence also demonstrates a likely role for these polyphenols as anticancer agents capable of preventing formation of new vasculature in neoplastic tissues. Polyphenols have also been shown to possess other anticancer properties such as specific cell-signaling actions that may stimulate the activity of the regulatory protein SIRT1. Additionally, polyphenolic compounds have demonstrated their inhibitory effects against chronic vascular inflammation associated with atherosclerosis. These increasingly well-documented results have begun to provide a basis for considering the use of polyphenols in the development of novel therapies for certain human diseases. And while the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases.

  3. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-01-01

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  4. Population aging.

    PubMed

    1999-04-01

    This paper focuses on the impact of population aging in China, the most densely populated country in the world. Statistics indicate that by the end of 1998, 83.75 million out of the 1.248 billion Chinese people will be over 65 years old. According to the UN standards, China will soon become an aging society. The aging population poses several challenges to the country with the greatest challenge being the increasing social responsibility to care for the aged. With the undeveloped legislative framework to protect the interests of the aged and the serious drawbacks in the pension system to cater only to the income part and not the service part of the aged, China is not yet ready for the advent of aging. Violation of the rights of senior citizens is still very rampant despite enactment of the law on Protection of the Rights of the Elderly in 1996. Moreover, China is not economically ready to become an aging society. China faces this challenge by adopting a three-pronged approach to solve the problem namely: family support, establishment of nursing homes, and creating a social security framework that addresses the needs of the society suited to the Chinese condition. It is believed that with the growing economy of the country and the rising income of its people, a comprehensive social security net will be created to take care of the aged.

  5. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-04-04

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  6. Topological lattice actions

    NASA Astrophysics Data System (ADS)

    Bietenholz, W.; Gerber, U.; Pepe, M.; Wiese, U.-J.

    2010-12-01

    We consider lattice field theories with topological actions, which are invariant against small deformations of the fields. Some of these actions have infinite barriers separating different topological sectors. Topological actions do not have the correct classical continuum limit and they cannot be treated using perturbation theory, but they still yield the correct quantum continuum limit. To show this, we present analytic studies of the 1-d O(2) and O(3) model, as well as Monte Carlo simulations of the 2-d O(3) model using topological lattice actions. Some topological actions obey and others violate a lattice Schwarz inequality between the action and the topological charge Q. Irrespective of this, in the 2-d O(3) model the topological susceptibility {χ_t} = {{{left< {{Q^2}} rightrangle }} left/ {V} right.} is logarithmically divergent in the continuum limit. Still, at non-zero distance the correlator of the topological charge density has a finite continuum limit which is consistent with analytic predictions. Our study shows explicitly that some classically important features of an action are irrelevant for reaching the correct quantum continuum limit.

  7. Spacelike brane actions.

    PubMed

    Hashimoto, Koji; Ho, Pei-Ming; Wang, John E

    2003-04-11

    We derive effective actions for "spacelike branes" (S-branes) and find a solution describing the formation of fundamental strings in the rolling tachyon background. The S-brane action is a Dirac-Born-Infeld action for Euclidean world volumes defined in the context of time-dependent tachyon condensation of non-BPS (Bogomol'nyi-Prasad-Sommerfield) branes. It includes gauge fields and, in particular, a scalar field associated with translation along the time direction. We show that the BIon spike solutions constructed in this system correspond to the production of a confined electric flux tube (a fundamental string) at late time of the rolling tachyon.

  8. Conscious Control over Action.

    PubMed

    Shepherd, Joshua

    2015-06-01

    The extensive involvement of nonconscious processes in human behaviour has led some to suggest that consciousness is much less important for the control of action than we might think. In this article I push against this trend, developing an understanding of conscious control that is sensitive to our best models of overt (that is, bodily) action control. Further, I assess the cogency of various zombie challenges-challenges that seek to demote the importance of conscious control for human agency. I argue that though nonconscious contributions to action control are evidently robust, these challenges are overblown.

  9. Conscious Control over Action

    PubMed Central

    Shepherd, Joshua

    2015-01-01

    The extensive involvement of nonconscious processes in human behaviour has led some to suggest that consciousness is much less important for the control of action than we might think. In this article I push against this trend, developing an understanding of conscious control that is sensitive to our best models of overt (that is, bodily) action control. Further, I assess the cogency of various zombie challenges—challenges that seek to demote the importance of conscious control for human agency. I argue that though nonconscious contributions to action control are evidently robust, these challenges are overblown. PMID:26113753

  10. Controlling Asthma New Guidelines. New Medications. New Action Plans.

    MedlinePlus

    ... version of this page please turn Javascript on. New Guidelines. New Medications. New Action Plans. People everywhere and in every age ... I am putting the finishing touches on my new studio album that we hope to have out ...

  11. Stabilizing bottomless action theories

    NASA Astrophysics Data System (ADS)

    Greensite, J.; Halpern, M. B.

    1984-08-01

    We show how to construct the euclidean quantum theory corresponding to classical actions which are unbounded from below. Our method preserves the classical limit, the large- N limit, and the perturbative expansion of the unstabilized theories.

  12. Benzidine Dyes Action Plan

    EPA Pesticide Factsheets

    This Action Plan addresses the use of benzidine-based dyes and benzidine congener-based dyes, both metalized and non-metalized, in products that would result in consumer exposure, such as for use to color textiles.

  13. Oak Canyon Action Memo

    EPA Pesticide Factsheets

    This memorandum requests approval for a time-critical removal action at the 27 residential properties that compose the Oak Canyon Site located in the Village of Paguate, Pueblo of Laguna, near Cibola County, New Mexico.

  14. Neural Mechanisms Underlying Action Observation in Adults with Down Syndrome

    ERIC Educational Resources Information Center

    Virji-Babul, Naznin; Moiseev, Alexander; Cheung, Teresa; Weeks, Daniel J.; Cheyne, Douglas; Ribary, Urs

    2010-01-01

    Results of a magnetoencephalography (MEG) brain imaging study conducted to examine the cortical responses during action execution and action observation in 10 healthy adults and 8 age-matched adults with Down syndrome are reported. During execution, the motor responses were strongly lateralized on the ipsilateral rather than the contralateral side…

  15. Children Show Heightened Memory for Threatening Social Actions

    ERIC Educational Resources Information Center

    Baltazar, Nicole C.; Shutts, Kristin; Kinzler, Katherine D.

    2012-01-01

    Three experiments investigated whether a negativity bias in social perception extends to preschool-aged children's memory for the details of others' social actions and experiences. After learning about individuals who committed nice or mean social actions, children in Experiment 1 were more accurate at remembering who was mean compared with who…

  16. Cardiac action potential imaging

    NASA Astrophysics Data System (ADS)

    Tian, Qinghai; Lipp, Peter; Kaestner, Lars

    2013-06-01

    Action potentials in cardiac myocytes have durations in the order of magnitude of 100 milliseconds. In biomedical investigations the documentation of the occurrence of action potentials is often not sufficient, but a recording of the shape of an action potential allows a functional estimation of several molecular players. Therefore a temporal resolution of around 500 images per second is compulsory. In the past such measurements have been performed with photometric approaches limiting the measurement to one cell at a time. In contrast, imaging allows reading out several cells at a time with additional spatial information. Recent developments in camera technologies allow the acquisition with the required speed and sensitivity. We performed action potential imaging on isolated adult cardiomyocytes of guinea pigs utilizing the fluorescent membrane potential sensor di-8-ANEPPS and latest electron-multiplication CCD as well as scientific CMOS cameras of several manufacturers. Furthermore, we characterized the signal to noise ratio of action potential signals of varying sets of cameras, dye concentrations and objective lenses. We ensured that di-8-ANEPPS itself did not alter action potentials by avoiding concentrations above 5 μM. Based on these results we can conclude that imaging is a reliable method to read out action potentials. Compared to conventional current-clamp experiments, this optical approach allows a much higher throughput and due to its contact free concept leaving the cell to a much higher degree undisturbed. Action potential imaging based on isolated adult cardiomyocytes can be utilized in pharmacological cardiac safety screens bearing numerous advantages over approaches based on heterologous expression of hERG channels in cell lines.

  17. [Addictions and action systems].

    PubMed

    Loonis, E; Apter, M J

    2000-01-01

    Generalizing from some previous analyses of addiction, and introducing the concept of an action system which governs all actions which are focussed on what Brown (1988) calls "hedonic management", we argue that addictions of every kind involve an action system that displays high salience, low variety and low vicariance. Addictions also involve what Apter (1982) calls the "paratelic state". A study was carried out comparing 31 drug addicts with 29 control subjects in terms of action system variables. To measure these variables, we constructed a new instrument, the Activity-System Drawing Test, and also used the Telic Dominance Scale to measure frequency of paratelic states. Dysphoria was measured by means of the BATE (anxiety), IDA-13 (depression), SEI (self-esteem), and TAS-20 (alexithymia) instruments. Strongly significant differences were found between groups for both action system variables and dysphoria, and there were also strong correlations between both groups of variables. This supports the idea that addictions emerge from systemic properties of the action system.

  18. Antisymmetric string actions

    NASA Astrophysics Data System (ADS)

    Aragone, C.

    1986-12-01

    An action is presented for the free bosonic string on external flat space in terms of an antisymmetric second-rank string background tensor which is classically equivalent to the Nambu-Goto action. Both action and field equations are entirely described in terms of 2D world-sheet forms, without any reference to a 2D metric tensor background. The analysis of its canonical formulation shows how the quadratic Virasoro constraints are generated in this case and what their connection with the Bianchi identities are. Since in the orthonormal gauge the reduced action coincides with the standard one, it has the same critical dimension D = 26. The existence of an interaction term of a purely geometric structure stemming in the extrinsic curvature is pointed out. Its action and the new string field equations are then derived. This polynomial antisymmetric string action is uniformly generalized in order to describe d < D-dimensional extended objects in D-dimensional flat space. On leave of absence from Departamento de Física, Universidad Simon Bolívar, Apartado 80659, Caracas 1080A, Venezuela.

  19. International Forum for Reactor Aging Management (IFRAM)

    SciTech Connect

    Bond, Leonard J.

    2010-11-01

    The Nuclear Regulatory Commission has undertaken a program to lay the groundwork for defining proactive actions to manage degradation of materials in light water reactors (LWRs). This article discusses the international forum for reactor aging management.

  20. Plan for early action: Recommendations

    SciTech Connect

    1998-12-31

    This report contains recommendations on the implementation of an action plan to reduce or recapture greenhouse gas (GHG) emissions in British Columbia. The report includes the consensus recommendations of the BC Greenhouse Gas Forum, as well as those items on which Forum participants have agreed to disagree, plus the reasons for those differences. The recommendations include: Umbrella actions which may affect several or all sectors of the economy, or support the success of other actions; actions to reduce vehicle kilometers travelled; actions to increase vehicle efficiency or increase the use of alternative fuels or technologies; actions to decrease GHG emissions from energy production; actions to increase end-use energy efficiency; and actions to reduce non-energy-related emissions. Appendices include work sheets on each action, with a description of the action and information on the action`s rationale, experience elsewhere, related policy initiatives, and key issues regarding feasibility and implementation.

  1. What's an Asthma Action Plan?

    MedlinePlus

    ... to 2-Year-Old What's an Asthma Action Plan? KidsHealth > For Parents > What's an Asthma Action Plan? ... normal everyday activities without having asthma symptoms. Action Plans Are Unique Each person's experience with asthma is ...

  2. Ageing doctors.

    PubMed

    Lillis, Steven; Milligan, Eleanor

    2017-03-01

    Doctors are neither more nor less susceptible than the general population to the effects of ageing. The relevance of deterioration with age depends on the nature of the work undertaken. Reduced muscle strength and visual and auditory deterioration can compromise clinical ability. Accumulation of chronic disease further reduces capacity. Cognitive decline is of particular importance, as good medical care requires considerable cognitive function. Patient safety is paramount, yet older doctors are an important part of the medical workforce and their value should be recognised. Changes in patient case mix, work place support systems and individual adjustments can assist safe practice. Deterioration in health should be acknowledged and requires proactive management. Current methods of ensuring competence are inadequate for supporting ageing doctors. A new initiative is recommended comprising collaboration between regulators, colleges and employing institutions to support the ageing doctor in providing safe and effective practice.

  3. [Neuronal ageing].

    PubMed

    Piechota, Małgorzata; Sunderland, Piotr

    2014-01-01

    Ageing leads to irreversible alterations in the nervous system, which to various extent impair its functions such as capacity to learn and memory. In old neurons and brain, similarly to what may take place in other cells, there is increased oxidative stress, disturbed energetic homeostasis and metabolism, accumulation of damage in proteins and nucleic acids. Characteristic of old neurons are alterations in plasticity, synaptic transmission, sensitivity to neurotrophic factors and cytoskeletal changes. Some markers of senescence, whose one of them is SA-beta-galactosidase were used to show the process of neuronal ageing both in vitro, and in vivo. Some research suggest that, despite the fact that neurons are postmitotic cells, it is cell cycle proteins which play a certain role in their biology, e.g. differentiation. However, their role in neuronal ageing is not known or explained. Ageing is the serious factor of development of neurodegenerative diseases among others Alzheimer disease.

  4. Immunological Aging

    EPA Science Inventory

    Immunosenescence is associated with an increased incidence and severity of infections with common pathogens, neoplastic disease and autoimmunity. In general, aging is associated with a decline in function at the cellular level, rather than cell loss, although thymic atrophy and ...

  5. Teen-Age Pregnancy: The Case for National Action.

    ERIC Educational Resources Information Center

    Wattleton, Faye

    1989-01-01

    Reviews the national impact of adolescent pregnancy with emphasis on the Black community. Criticizes the mass media for exploiting sexual behavior. Proposes a national agenda incorporating comprehensive sex education, family planning services, and educational, economic, and social opportunities. (FMW)

  6. Age matters.

    PubMed

    McCutcheon, James Edgar; Marinelli, Michela

    2009-03-01

    The age of an experimental animal can be a critical variable, yet age matters are often overlooked within neuroscience. Many studies make use of young animals, without considering possible differences between immature and mature subjects. This is especially problematic when attempting to model traits or diseases that do not emerge until adulthood. In this commentary we discuss the reasons for this apparent bias in age of experimental animals, and illustrate the problem with a systematic review of published articles on long-term potentiation. Additionally, we review the developmental stages of a rat and discuss the difficulty of using the weight of an animal as a predictor of its age. Finally, we provide original data from our laboratory and review published data to emphasize that development is an ongoing process that does not end with puberty. Developmental changes can be quantitative in nature, involving gradual changes, rapid switches, or inverted U-shaped curves. Changes can also be qualitative. Thus, phenomena that appear to be unitary may be governed by different mechanisms at different ages. We conclude that selection of the age of the animals may be critically important in the design and interpretation of neurobiological studies.

  7. Understanding aging.

    PubMed

    Strehler, B L

    2000-01-01

    Enormous advances in our understanding of human aging have occurred during the last 50 yr. From the late 19th to the mid-20th centuries only four comprehensive and important sources of information were available: 1. August Weismann's book entitled Essays on Heredity and Kindred Biological Problems (the first of these essays dealt with The Duration of Life; 1). Weissmann states (p. 10) "In the first place in regulating the length of life, the advantage to the species, and not to the individual, is alone of any importance. This must be obvious to any one who has once thoroughly thought out the process of natural selection_". 2. A highly systematized second early source of information on aging was the collection of essays edited by Cowdry and published in 1938. This 900+ page volume contains 34 chapters and was appropriately called Problems of Aging. 3. At about the same time Raymond Pearl published his book on aging (2). Pearl believed that aging was the indirect result of cell specialization and that only the germ line was resistant to aging. Unfortunately Pearl died in the late 1930s and is largely remembered now for having been the founding editor of Quarterly Review of Biology while he was at the Johns Hopkins University, this author's alma mater. 4. Alexis Carrel wrote a monumental scientific and philosophical book, Man, the Unknown (3). Carrel believed that he had demonstrated that vertebrate cells could be kept in culture and live indefinitely, a conclusion challenged by others (more on this later).

  8. COGNITION, ACTION, AND OBJECT MANIPULATION

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Weigelt, Matthias; Weiss, Daniel J.; van der Wel, Robrecht

    2012-01-01

    Although psychology is the science of mental life and behavior, it has paid little attention to the means by which mental life is translated into behavior. One domain where links between cognition and action have been explored is the manipulation of objects. This article reviews psychological research on this topic, with special emphasis on the tendency to grasp objects differently depending on what one plans to do with the objects. Such differential grasping has been demonstrated in a wide range of object manipulation tasks, including grasping an object in a way that reveals anticipation of the object's future orientation, height, and required placement precision. Differential grasping has also been demonstrated in a wide range of behaviors, including one-hand grasps, two-hand grasps, walking, and transferring objects from place to place as well as from person to person. The populations in whom the tendency has been shown are also diverse, including nonhuman primates as well as human adults, children, and babies. Meanwhile, the tendency is compromised in a variety of clinical populations and in children of a surprisingly advanced age. Verbal working memory is compromised as well if words are memorized while object manipulation tasks are performed; the recency portion of the serial position curve is reduced in this circumstance. In general, the research reviewed here points to rich connections between cognition and action as revealed through the study of object manipulation. Other implications concern affordances, Donders' Law, and naturalistic observation and the teaching of psychology. PMID:22448912

  9. Classifying Facial Actions

    PubMed Central

    Donato, Gianluca; Bartlett, Marian Stewart; Hager, Joseph C.; Ekman, Paul; Sejnowski, Terrence J.

    2010-01-01

    The Facial Action Coding System (FACS) [23] is an objective method for quantifying facial movement in terms of component actions. This system is widely used in behavioral investigations of emotion, cognitive processes, and social interaction. The coding is presently performed by highly trained human experts. This paper explores and compares techniques for automatically recognizing facial actions in sequences of images. These techniques include analysis of facial motion through estimation of optical flow; holistic spatial analysis, such as principal component analysis, independent component analysis, local feature analysis, and linear discriminant analysis; and methods based on the outputs of local filters, such as Gabor wavelet representations and local principal components. Performance of these systems is compared to naive and expert human subjects. Best performances were obtained using the Gabor wavelet representation and the independent component representation, both of which achieved 96 percent accuracy for classifying 12 facial actions of the upper and lower face. The results provide converging evidence for the importance of using local filters, high spatial frequencies, and statistical independence for classifying facial actions. PMID:21188284

  10. ES H action plan

    SciTech Connect

    Not Available

    1991-01-01

    This document contains planned actions to correct the deficiencies identified in the Pre-Tiger Team Self-Assessment (PTTSA), January 1991, of Sandia National Laboratories (SNL -- Albuquerque, New Mexico; Tonopah, Nevada; and Kauai, Hawaii). The Self-Assessment was conducted by a Self-Assessment Working Group consisting of 19 department managers, with support from Environment, Safety, and Health (ES H) professionals, from October through December 1990. Findings from other past audits, dating back to 1985, were reviewed and compared with the PTTSA findings to determine if additional findings, key findings, or root causes were warranted. The resulting ES H Action Plan and individual planned actions were prepared by the ES H Action Plan Project Group with assistance from the Program owners/authors during February and March 1991. The plan was reviewed by SNL Management in April 1991. This document serves as a planning instrument for the Laboratories to aid in the scoping and sizing of activities related to ES H compliance for the coming five years. It will be modified as required to ensure a workload/funding balance and to address the findings resulting from the Tiger Team assessment at SNL, Albuquerque. The process of producing this document has served well to prepare SNL, Albuquerque, for the coming task of producing the required post-Tiger Team action plan document. 8 tabs.

  11. [Driving and aging].

    PubMed

    Cantón-Cortés, David; Durán Segura, Mercedes; Castro Ramírez, Cándida

    2010-01-01

    The number of older people who continue to drive is constantly increasing. However, whether older people have more traffic accidents than other age groups is unclear. This age group has certain risk factors due to decreased motor, sensory and cognitive functions and also has greater frailty and vulnerability to injury. However, older drivers are aware of their heightened crash risk and employ certain compensatory actions, avoiding traveling under threatening conditions (dense traffic, bad weather or night driving), traveling by well-known routes and driving carefully. In view of these apparent contradictions, the present study attempts to discern the real crash risk and the driving and crash patterns characteristic of this population, which is continually increasing in industrialized countries.

  12. Action languages: Dimensions, effects

    NASA Technical Reports Server (NTRS)

    Hayes, Daniel G.; Streeter, Gordon

    1989-01-01

    Dimensions of action languages are discussed for communication between humans and machines, and the message handling capabilities of object oriented programming systems are examined. Design of action languages is seen to be very contextual. Economical and effective design will depend on features of situations, the tasks intended to be accomplished, and the nature of the devices themselves. Current object oriented systems turn out to have fairly simple and straightforward message handling facilities, which in themselves do little to buffer action or even in some cases to handle competing messages. Even so, it is possible to program a certain amount of discretion about how they react to messages. Such thoughtfulness and perhaps relative autonomy of program modules seems prerequisite to future systems to handle complex interactions in changing situations.

  13. Mitigation Action Plan

    SciTech Connect

    Not Available

    1994-02-01

    This Mitigation Action Plan (MAP) focuses on mitigation commitments stated in the Supplemental Environmental Impact Statement (SEIS) and the Record of Decision (ROD) for the Naval Petroleum Reserve No. 1 (NPR-1). Specific commitments and mitigation implementation actions are listed in Appendix A-Mitigation Actions, and form the central focus of this MAP. They will be updated as needed to allow for organizational, regulatory, or policy changes. It is the intent of DOE to comply with all applicable federal, state, and local environmental, safety, and health laws and regulations. Eighty-six specific commitments were identified in the SEIS and associated ROD which pertain to continued operation of NPR-1 with petroleum production at the Maximum Efficient Rate (MER). The mitigation measures proposed are expected to reduce impacts as much as feasible, however, as experience is gained in actual implementation of these measures, some changes may be warranted.

  14. Taking Action: An Educator's Guide to Involving Students in Environmental Action Projects.

    ERIC Educational Resources Information Center

    Stoner, Darlene K.; And Others

    The goal of Project WILD, a K-12 interdisciplinary conservation and environmental education program emphasizing wildlife, is to assist learners of any age in developing awareness, knowledge, skills, and commitment resulting in informed decisions, responsible behavior, and constructive actions concerning wildlife and the environment. The purpose of…

  15. Characterizations of proper actions

    NASA Astrophysics Data System (ADS)

    Biller, Harald

    2004-03-01

    Three kinds of proper actions of increasing strength are defined. We prove that the three definitions specialize to the definitions by Bourbaki, by Palais and by Baum, Connes and Higson in their respective settings. The third of these, which thus turns out to be the strongest, originally only concerns actions of second countable locally compact groups on metrizable spaces. In this situation, it is shown to coincide with the other two definitions if the total space locally has the Lindelöf property and the orbit space is regular.

  16. Age Rules

    NASA Astrophysics Data System (ADS)

    Taylor, G. J.

    2015-10-01

    The ages of rocks from the lunar highlands vary widely, even for a single rock sample. This makes it difficult to quantitatively test ideas for early lunar differentiation and formation of the crust. Lars Borg and Amy Gaffney (Lawrence Livermore National Laboratory), and Charles Shearer (University of New Mexico) have devised a set of guidelines to apply to geochronological data that leads to a relative ranking of the reliability of the age determined for a sample. Applying their guidelines to existing data for lunar highland rocks shows an upper limit on rock ages between 4340 and 4370 million years. This is essentially the same as the so-called model ages of the formation of KREEP (a chemical component enriched in potassium, rare earth elements, and phosphorous) and of the formation of the deep source regions that melted to produce mare basalts. The numerous ages close to 4370 million years suggests a complicated and protracted cooling of the primordial lunar magma ocean or a widespread vigorous period of magmatic activity in the Moon.

  17. Obesity in the ageing man.

    PubMed

    Michalakis, K; Goulis, D G; Vazaiou, A; Mintziori, G; Polymeris, A; Abrahamian-Michalakis, A

    2013-10-01

    As the population is ageing globally, both ageing and obesity are recognized as major public health challenges. The aim of this narrative review is to present and discuss the current evidence on the changes in body composition, energy balance and endocrine environment that occur in the ageing man. Obesity in the ageing man is related to changes in both body weight and composition due to alterations in energy intake and total energy expenditure. In addition, somatopenia (decreased GH secretion), late-onset hypogonadism (LOH), changes in thyroid and adrenal function, as well as changes in appetite-related peptides (leptin, ghrelin) and, most importantly, insulin action are related to obesity, abnormal energy balance, redistribution of the adipose tissue and sarcopenia (decreased muscle mass). A better understanding of the complex relationship of ageing-related endocrine changes and obesity could lead to more effective interventions for elderly men.

  18. Angels in Action

    ERIC Educational Resources Information Center

    Stylianou, Xanthippi Cynthia

    2009-01-01

    In this article, the author discusses the importance of the placement of action lines to show the direction of movement. The author shows some visuals of angels and discusses in details the texture of the wings, the hair and the clothing.

  19. Executive Mind, Timely Action.

    ERIC Educational Resources Information Center

    Torbert, William R.

    1983-01-01

    The idea of "Executive Mind" carries with it the notion of purposeful and effective action. Part I of this paper characterizes three complements to "Executive Mind"--"Observing Mind,""Theorizing Mind," and "Passionate Mind"--and offers historical figures exemplifying all four types. The concluding…

  20. College Comedy and Action

    ERIC Educational Resources Information Center

    Moore, Rosanna

    1977-01-01

    A few materials such as yarn and scraps of paper and cloth can provide the media for recording limitless ideas from the imaginations of students. With a little encouragement and a few suggestions of actions, emotions, exaggerations and activities students will produce a vast array of amusing characters. (Author)

  1. Affirmative Action Plan.

    ERIC Educational Resources Information Center

    Triton Coll., River Grove, IL.

    In order to develop an affirmative action plan at Triton College, the college President appointed a committee made up of nine representatives from the various college constituencies, the majority of which were women and minorities, to determine the objectives to be achieved and how to implement them, and to establish appropriate review procedures.…

  2. Youth Engaged for Action

    ERIC Educational Resources Information Center

    Post, Margaret; Little, Priscilla

    2005-01-01

    This article examines how out-of-school time programs can promote youth involvement in civic action by focusing on four interrelated programmatic strategies: establishing organizational readiness that fosters engagement; promoting youth-adult partnerships; engaging youth as leaders and decision makers; and involving youth in research and…

  3. Expert Teacher Action Program.

    ERIC Educational Resources Information Center

    Washington, Eva

    The expert teacher action program is to improve classroom teaching performance. The program has been tested in workshop sessions involving more than 1,200 educators representing 50 school districts. A set of standards, consisting of 25 variables, lead to the definition of expert teaching. Each variable deals with a major aspect of the duties of…

  4. Court Action for Migrants.

    ERIC Educational Resources Information Center

    Ewald, Thomas R.

    Aiding attorneys who represent migrant farmworkers and their families when affirmative civil action is required, this book helps to raise the level of migrants' legal protection to a minimum standard of adequacy. The text is based on the Federal Rules of Civil Procedure, a national set of rules. The book is divided into 3 sections: the…

  5. Action for Children's Television.

    ERIC Educational Resources Information Center

    Ranly, Donald P.

    The origins, development, and effectiveness of Action for Children's Television (ACT) are examined in this pamphlet. The strategies used by ACT to obtain change at the congressional level and within television stations and networks include the following: a "tuneout" day when people are urged to turn off their television sets, a boycott…

  6. School Reform in Action.

    ERIC Educational Resources Information Center

    Miller, A. Christine

    This study describes and analyzes the impact on student learning and the learning environment of 55 schools in Broward, Palm Beach, and Miami-Dade school districts as they implemented the schoolwide action-research framework for school improvement. Interviews, observations, document review during site visits, school framework reports, surveys,…

  7. Cognitive framing in action.

    PubMed

    Huhn, John M; Potts, Cory Adam; Rosenbaum, David A

    2016-06-01

    Cognitive framing effects have been widely reported in higher-level decision-making and have been ascribed to rules of thumb for quick thinking. No such demonstrations have been reported for physical action, as far as we know, but they would be expected if cognition for physical action is fundamentally similar to cognition for higher-level decision-making. To test for such effects, we asked participants to reach for a horizontally-oriented pipe to move it from one height to another while turning the pipe 180° to bring one end (the "business end") to a target on the left or right. From a physical perspective, participants could have always rotated the pipe in the same angular direction no matter which end was the business end; a given participant could have always turned the pipe clockwise or counter-clockwise. Instead, our participants turned the business end counter-clockwise for left targets and clockwise for right targets. Thus, the way the identical physical task was framed altered the way it was performed. This finding is consistent with the hypothesis that cognition for physical action is fundamentally similar to cognition for higher-level decision-making. A tantalizing possibility is that higher-level decision heuristics have roots in the control of physical action, a hypothesis that accords with embodied views of cognition.

  8. Nutrition Action Pack.

    ERIC Educational Resources Information Center

    Sockut, Joanne; Stumpe, Stephanie

    One of five McDonald's Action Packs, these instructional materials integrate elementary school-level nutrition education into other disciplines--biology, sociology, physiology, mathematics, and art. Contents include four units consisting of twelve activities. Unit 1, Why You Need Food, is a self-examination of what is needed for growth, health,…

  9. Sustainability as Moral Action

    ERIC Educational Resources Information Center

    Dunn, Merrily S.; Hart-Steffes, Jeanne S.

    2012-01-01

    When one considers sustainability as a moral action, there are equally complex realities at hand--climate change, resource depletion, water and land rights. One author describes this broad sense of sustainability as "the connection of specific social and environmental problems to the functioning of human and ecological systems" (Jenkins, 2011).…

  10. Conjugate flow action functionals

    NASA Astrophysics Data System (ADS)

    Venturi, Daniele

    2013-11-01

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  11. Economics Action Pack.

    ERIC Educational Resources Information Center

    McDonald's Corp., Oak Brook, IL.

    One of five McDonald's Action Packs, this learning package introduces intermediate grade students to basic economic concepts. The fourteen activities include the topics of consumption (4 activities), production (5), the market system (3), a pretest, and a posttest. Specific titles under consumption include The Wonderful Treasure Tree (introduction…

  12. From Awareness to Action

    ERIC Educational Resources Information Center

    Micklos, John, Jr.

    2012-01-01

    What inspires young people to become activists? Events such as wars or regime changes obviously raise high emotions. But some choose to get involved because they saw a need and felt compelled to take action. Young Americans have a long track record as activists. Among other things, they played a key role in the civil rights movement of the 1950s…

  13. Affirmative Action Fallout

    ERIC Educational Resources Information Center

    Roach, Ronald

    2005-01-01

    Race-conscious affirmative action in higher education survived a close challenge in 2003 when the U.S. Supreme Court ruled that race was a valid academic admission criteria in the "Grutter v. Bollinger" case. Two years later, a number of "pipeline" programs to help under-represented minorities gain admission to and complete graduate school have…

  14. Conjugate flow action functionals

    SciTech Connect

    Venturi, Daniele

    2013-11-15

    We present a new general framework to construct an action functional for a non-potential field theory. The key idea relies on representing the governing equations relative to a diffeomorphic flow of curvilinear coordinates which is assumed to be functionally dependent on the solution field. Such flow, which will be called the conjugate flow, evolves in space and time similarly to a physical fluid flow of classical mechanics and it can be selected in order to symmetrize the Gâteaux derivative of the field equations with respect to suitable local bilinear forms. This is equivalent to requiring that the governing equations of the field theory can be derived from a principle of stationary action on a Lie group manifold. By using a general operator framework, we obtain the determining equations of such manifold and the corresponding conjugate flow action functional. In particular, we study scalar and vector field theories governed by second-order nonlinear partial differential equations. The identification of transformation groups leaving the conjugate flow action functional invariant could lead to the discovery of new conservation laws in fluid dynamics and other disciplines.

  15. The Constitution in Action

    ERIC Educational Resources Information Center

    Potter, Lee Ann

    2007-01-01

    In this article, the author describes the experiences middle school students on a field trip to the new Constitution in Action Learning Lab in the Boeing Learning Center at the National Archives can expect. There, middle school students take on the roles of archivists and researchers collecting and analyzing primary sources from the holdings of…

  16. Jump into Action

    ERIC Educational Resources Information Center

    Ball, Stephen; Cohen, Ann; Meyer, Margaret

    2012-01-01

    Jump Into Action (JIA) is a school-based team-taught program to help fifth-grade students make healthy food choices and be more active. The JIA team (physical education teacher, classroom teacher, school nurse, and parent) work together to provide a supportive environment as students set goals to improve food choices and increase activity.…

  17. Hope for Environmental Action

    ERIC Educational Resources Information Center

    Fleischer, Barbara J.; DeMoor, Emily

    2015-01-01

    Environmental consciousness-raising programs tend to emphasize the magnitude of imminent ecological disasters, if humans continue on their current trajectory. While these environmental literacy programs also call for action to avoid cataclysmic ecological changes, psychological research on "learned helplessness" suggests that information…

  18. Action Learning Issues.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on adult learning issues and human resource development (HRD). "Creating a Systemic Framework for the Transfer of Learning from an Action Learning Experience" (Suzanne D. Butterfield, Kitty Gold, Verna J. Willis) discusses a study of the organizational elements that affect learning and…

  19. Target: Development Action.

    ERIC Educational Resources Information Center

    American Freedom from Hunger Foundation, Washington, DC. Young World Development.

    This handbook, suggestive rather than prescriptive, is written for Young World Development and/or similar groups committed to active involvement in community, national, and world improvement. Emphasis is upon organizing high school, college, and adult courses and action programs in the community which will help sensitize participants and make them…

  20. Justifying Action Research

    ERIC Educational Resources Information Center

    Helskog, Guro Hansen

    2014-01-01

    In this paper I use a general philosophy of science perspective in looking at the problem of justifying action research. First I try to clarify the concept of justification, by contrasting it with the concept of validity, which seems to be used almost as a synonym in some parts of the literature. I discuss the need for taking a stand in relation…

  1. Classroom Assessment in Action

    ERIC Educational Resources Information Center

    Shermis, Mark D.; DiVesta, Francis J.

    2011-01-01

    "Classroom Assessment in Action" clarifies the multi-faceted roles of measurement and assessment and their applications in a classroom setting. Comprehensive in scope, Shermis and Di Vesta explain basic measurement concepts and show students how to interpret the results of standardized tests. From these basic concepts, the authors then…

  2. Quick action clamp

    NASA Technical Reports Server (NTRS)

    Calco, Frank S. (Inventor)

    1991-01-01

    A quick release toggle clamp that utilizes a spring that requires a deliberate positive action for disengagement is presented. The clamp has a sliding bolt that provides a latching mechanism. The bolt is moved by a handle that tends to remain in an engaged position while under tension.

  3. SYRACUSE ACTION FOR YOUTH.

    ERIC Educational Resources Information Center

    ADDINGTON, HAROLD E.; AND OTHERS

    A PROPOSAL WAS MADE TO PREVENT AND CONTROL JUVENILE DELINQUENCY BY OPENING OPPORTUNITIES AND DEVELOPING COMPETENCE AMONG DISADVANTAGED YOUTH. THE TOTAL COMMUNITY WAS MOBILIZED TO DEVELOP A PROGRAM TO ATTACK THE PROBLEM AT ALL LEVELS THEY WORKED FOR 18 MONTHS TO PLAN A SERIES OF CREATIVE ACTION PROGRAMS IN EDUCATION, EMPLOYMENT, AND COMMUNITY…

  4. The Shape of Action

    ERIC Educational Resources Information Center

    Hard, Bridgette Martin; Recchia, Gabriel; Tversky, Barbara

    2011-01-01

    How do people understand the everyday, yet intricate, behaviors that unfold around them? In the present research, we explored this by presenting viewers with self-paced slideshows of everyday activities and recording looking times, subjective segmentation (breakpoints) into action units, and slide-to-slide physical change. A detailed comparison of…

  5. Gay aging.

    PubMed

    Haber, David

    2009-01-01

    The oldest of the baby boomers (boomers) were age 63 in 2009 and on the verge of retirement. This cohort has had a history of making societal changes throughout its life cycle, and it is unlikely that retirement, as we know it, will remain unscathed. This article highlights two events-the Stonewall Inn riots and two prominent professional associations removing homosexuality from their list of personality disorders-and how they occurred early enough in the gay boomers life cycle to change their attitudes, behaviors, and lifestyles. This article introduces the reader to a broad array of facts, research findings, and issues that inform the topic of gay aging. A summary of the discrimination and legal concerns affecting the gay community are also highlighted. Two influential community programs are identified: Services and Advocacy for Gay Elders (SAGE) and the American Society on Aging's LGBT Aging Issues Network (LAIN). Gerontological educators need to be sensitive to the needs, desires, and resources of the coming cohort of gay boomers, who are more likely to advocate for responsive services, organizations, and policies than the current cohort of gay older adults.

  6. Aging Secret

    ERIC Educational Resources Information Center

    Journal of College Science Teaching, 2005

    2005-01-01

    The canny world of advertising has caught on to the free radical theory of aging, marketing a whole array of antioxidants for preventing anything from wrinkles to dry hair to reducing the risk of heart disease--promising to help slow the hands of time. Working with genetically engineered mice--to produce a natural antioxidant enzyme called…

  7. 45 CFR 1156.7 - Exceptions to the rules against age discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Exceptions to the rules against age discrimination... AGE Standards for Determining Discriminatory Practices § 1156.7 Exceptions to the rules against age... to take an action otherwise prohibited by § 1156.6 if the action reasonably takes into account age...

  8. 45 CFR 1156.7 - Exceptions to the rules against age discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Exceptions to the rules against age discrimination... AGE Standards for Determining Discriminatory Practices § 1156.7 Exceptions to the rules against age... to take an action otherwise prohibited by § 1156.6 if the action reasonably takes into account age...

  9. 45 CFR 1156.7 - Exceptions to the rules against age discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Exceptions to the rules against age discrimination... AGE Standards for Determining Discriminatory Practices § 1156.7 Exceptions to the rules against age... to take an action otherwise prohibited by § 1156.6 if the action reasonably takes into account age...

  10. 40 CFR 7.155 - Exceptions to the rules against age discrimination-reasonable factors other than age.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... against age discrimination—reasonable factors other than age. A recipient is permitted to take an action... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Exceptions to the rules against age discrimination-reasonable factors other than age. 7.155 Section 7.155 Protection of Environment...

  11. 29 CFR 35.13 - Exceptions to the rules against age discrimination: reasonable factors other than age.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Exceptions to the rules against age discrimination... DEPARTMENT OF LABOR Standards for Determining Age Discrimination § 35.13 Exceptions to the rules against age discrimination: reasonable factors other than age. A recipient is permitted to take an action...

  12. A Metadata Action Language

    NASA Technical Reports Server (NTRS)

    Golden, Keith; Clancy, Dan (Technical Monitor)

    2001-01-01

    The data management problem comprises data processing and data tracking. Data processing is the creation of new data based on existing data sources. Data tracking consists of storing metadata descriptions of available data. This paper addresses the data management problem by casting it as an AI planning problem. Actions are data-processing commands, plans are dataflow programs and goals are metadata descriptions of desired data products. Data manipulation is simply plan generation and execution, and a key component of data tracking is inferring the effects of an observed plan. We introduce a new action language for data management domains, called ADILM. We discuss the connection between data processing and information integration and show how a language for the latter must be modified to support the former. The paper also discusses information gathering within a data-processing framework, and show how ADILM metadata expressions are a generalization of Local Completeness.

  13. Adipokines and insulin action

    PubMed Central

    Knights, Alexander J; Funnell, Alister PW; Pearson, Richard CM; Crossley, Merlin; Bell-Anderson, Kim S

    2014-01-01

    Obesity is a major public health concern and a strong risk factor for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The last two decades have seen a reconsideration of the role of white adipose tissue (WAT) in whole body metabolism and insulin action. Adipose tissue-derived cytokines and hormones, or adipokines, are likely mediators of metabolic function and dysfunction. While several adipokines have been associated with obese and insulin-resistant phenotypes, a select group has been linked with insulin sensitivity, namely leptin, adiponectin, and more recently, adipolin. What is known about these insulin-sensitizing molecules and their effects in healthy and insulin resistant states is the subject of this review. There remains a significant amount of research to do to fully elucidate the mechanisms of action of these adipokines for development of therapeutics in metabolic disease. PMID:24719781

  14. Atoms in Action

    SciTech Connect

    2009-01-01

    This movie produced with Berkeley Lab's TEAM 0.5 microscope shows the growth of a hole and the atomic edge reconstruction in a graphene sheet. An electron beam focused to a spot on the sheet blows out the exposed carbon atoms to make the hole. The carbon atoms then reposition themselves to find a stable configuration. http://newscenter.lbl.gov/press-releases/2009/03/26/atoms-in-action/

  15. Battle Space Action Centers

    DTIC Science & Technology

    2011-05-14

    VREEDE, G. J. D., & KOLFSCHOTEN, G. L . (2008). Extending the contextual and organizational elements of adaptive structurization theory in GSS...Reiter-Palmon, R., & Harland, L . (2009). Computer Assisted Collaboration Engineering and Process Support Systems: The BattleSpace ActionCenters...Collaboration Science, 27 February, University of Nebraska at Omaha, Omaha, NE. 18. BRIGGS, R.O., VREEDE, G.J. DE, REITER-PALMON, R., HARLAND, L

  16. 78 FR 76636 - Agency Information Collection Activities: Consideration of Deferred Action for Childhood Arrivals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... of Deferred Action for Childhood Arrivals, Form I-821D; Revision of a Currently Approved Collection...) Title of the Form/Collection: Consideration of Deferred Action for Childhood Arrivals. (3) Agency form... be considered for deferred action for childhood arrivals: 1. Were under the age of 31 as of June...

  17. Making Tracks 1.0: Action Researching an Active Transportation Education Program

    ERIC Educational Resources Information Center

    Robinson, Daniel; Foran, Andrew; Robinson, Ingrid

    2014-01-01

    This paper reports on the results of the first cycle of an action research project. The objective of this action research was to examine the implementation of a school-based active transportation education program (Making Tracks). A two-cycle action research design was employed in which elementary school students' (ages 7-9), middle school…

  18. Finding minimal action sequences with a simple evaluation of actions

    PubMed Central

    Shah, Ashvin; Gurney, Kevin N.

    2014-01-01

    Animals are able to discover the minimal number of actions that achieves an outcome (the minimal action sequence). In most accounts of this, actions are associated with a measure of behavior that is higher for actions that lead to the outcome with a shorter action sequence, and learning mechanisms find the actions associated with the highest measure. In this sense, previous accounts focus on more than the simple binary signal of “was the outcome achieved?”; they focus on “how well was the outcome achieved?” However, such mechanisms may not govern all types of behavioral development. In particular, in the process of action discovery (Redgrave and Gurney, 2006), actions are reinforced if they simply lead to a salient outcome because biological reinforcement signals occur too quickly to evaluate the consequences of an action beyond an indication of the outcome's occurrence. Thus, action discovery mechanisms focus on the simple evaluation of “was the outcome achieved?” and not “how well was the outcome achieved?” Notwithstanding this impoverishment of information, can the process of action discovery find the minimal action sequence? We address this question by implementing computational mechanisms, referred to in this paper as no-cost learning rules, in which each action that leads to the outcome is associated with the same measure of behavior. No-cost rules focus on “was the outcome achieved?” and are consistent with action discovery. No-cost rules discover the minimal action sequence in simulated tasks and execute it for a substantial amount of time. Extensive training, however, results in extraneous actions, suggesting that a separate process (which has been proposed in action discovery) must attenuate learning if no-cost rules participate in behavioral development. We describe how no-cost rules develop behavior, what happens when attenuation is disrupted, and relate the new mechanisms to wider computational and biological context. PMID:25506326

  19. Platform for Action: update.

    PubMed

    1995-01-01

    The Center for Women's Global Leadership (CWGL) has collaborated in the preparation of amendments and strategies designed to withstand the challenges being posed to the Platform for Action of the Fourth World Conference on Women. Specific challenges include the inappropriate use of the word "universal" to modify "human rights." This implies that some human rights are less than universal. The strategy proposed is to accept the use of the word "universal" in this context only when it affirms principles of universality contained in the Vienna Programme of Action and not where its use would restrict the rights to which women are entitled. A second concern is over the use of the word "equity" rather than "equality" when referring to gender relations. The use of these terms will be carefully monitored to insure that "equity" not be used to undermine the principle of gender equality. The third concern is the efforts of some governments to hinder the integration of women's human rights throughout the UN system. Such efforts will be opposed. Fourth, the CWGL will seek the inclusion of language which recognizes the barriers that different groups of women face when trying to secure their rights. Finally, the CWGL will propose inclusion of language recognizing and protecting sexual orientation rights. The CWGL is also going to work to translate the abstract language of the Platform for Action into political organizing potential to insure that governments will follow through on their agreements.

  20. Empirical microeconomics action functionals

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  1. Archetypes as action patterns.

    PubMed

    Hogenson, George B

    2009-06-01

    The discovery of mirror neurons by researchers at the University of Parma promises to radically alter our understanding of fundamental cognitive and affective states. This paper explores the relationship of mirror neurons to Jung's theory of archetypes and proposes that archetypes may be viewed as elementary action patterns. The paper begins with a review of a proposed interpretation of the fainting spells of S. Freud in his relationship with Jung as an example of an action pattern that also defines an archetypal image. The challenge that mirror neurons present to traditional views in analytical psychology and psychoanalysis, however, is that they operate without recourse to a cognitive processing element. This is a position that is gaining increasing acceptance in other fields as well. The paper therefore reviews the most recent claims made by the Boston Process of Change Study Group as well as conclusions drawn from dynamic systems views of development and theoretical robotics to underline the conclusion that unconscious agency is not a requirement for coherent action. It concludes with the suggestion that this entire body of research may lead to the conclusion that the dynamic unconscious is an unnecessary hypothesis in psychoanalysis and analytical psychology.

  2. Action Planning in Typically and Atypically Developing Children (Unilateral Cerebral Palsy)

    ERIC Educational Resources Information Center

    Craje, Celine; Aarts, Pauline; Nijhuis-van der Sanden, Maria; Steenbergen, Bert

    2010-01-01

    In the present study, we investigated the development of action planning in children with unilateral Cerebral Palsy (CP, aged 3-6 years, n = 24) and an age matched control group. To investigate action planning, participants performed a sequential movement task. They had to grasp an object (a wooden play sword) and place the sword in a hole in a…

  3. Action spectra for photosynthetic inhibition

    NASA Technical Reports Server (NTRS)

    Caldwell, M. M.; Flint, S.; Camp, L. B.

    1981-01-01

    The ultraviolet action spectrum for photosynthesis inhibition was determined to fall between that of the general DNA action spectrum and the generalized plant action spectrum. The characteristics of this action spectrum suggest that a combination of pronounced increase in effectiveness with decreasing wavelength, substantial specificity for the UV-B waveband, and very diminished response in the UV-A waveband result in large radiation amplification factors when the action spectra are used as weighting functions. Attempted determination of dose/response relationships for leaf disc inhibition provided inconclusive data from which to deconvolute an action spectrum.

  4. 25 CFR 41.6 - HHS participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Director of Education in the development of plans, procedures, and criteria for feasibility studies under this subpart, and to provide the Director with technical assistance in conducting such feasibility studies, including determinations as to the reasonable number of students required to support a...

  5. On the Inclusion of Externally Controlled Actions in Action Planning

    ERIC Educational Resources Information Center

    Tsai, Jessica Chia-Chin; Knoblich, Gunther; Sebanz, Natalie

    2011-01-01

    According to ideomotor theories, perceiving action effects produced by others triggers corresponding action representations in the observer. We tested whether this principle extends to actions performed by externally controlled limbs and tools. Participants performed a go-no-go version of a spatial compatibility task in which their own actions…

  6. VIOLENT FRAMES IN ACTION

    SciTech Connect

    Sanfilippo, Antonio P.; McGrath, Liam R.; Whitney, Paul D.

    2011-11-17

    We present a computational approach to radical rhetoric that leverages the co-expression of rhetoric and action features in discourse to identify violent intent. The approach combines text mining and machine learning techniques with insights from Frame Analysis and theories that explain the emergence of violence in terms of moral disengagement, the violation of sacred values and social isolation in order to build computational models that identify messages from terrorist sources and estimate their proximity to an attack. We discuss a specific application of this approach to a body of documents from and about radical and terrorist groups in the Middle East and present the results achieved.

  7. Public affairs committee actions

    NASA Astrophysics Data System (ADS)

    The AGU Public Affairs Committee will create an ad hoc committee to consider possible AGU position statements concerning the effects of nuclear war.The action was taken at the May 31, 1983, meeting of the Committee at the AGU Spring Meeting in Baltimore. Present were Carroll Ann Hodges, Chairman, and members Thomas J. Ahrens, David Cauffman, Jared Cohon, Stamatios Krimigis, Robert Murphy, Raymond Roble, and George Shaw. Also attending were the current Congressional Fellow Arthur Weissman and SPR—Cosmic Rays Section Secretary Miriam Forman.

  8. Neurobiological actions of cysteamine

    SciTech Connect

    Brown, M.; Fisher, L.; Mason, R.T.; Rivier, J.; Vale, W.

    1985-06-01

    Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.

  9. 3RS action plan

    SciTech Connect

    Not Available

    1990-01-01

    The goal of the Solid Waste Interim Steering Committee (SWISC) process is to develop a long-term waste management system for the Greater Toronto Area (GTA), to be in place by 1996, which is environmentally, socially, economically and technically sound. This background report is being released to the public and member Regional Councils to facilitate input to the SWISC planning process. The report documents current reduction, reuse and recycling initiatives in the GTA, identifies opportunities for coordination and collaboration among the GTA communities, and develops an action plan for improving the effectiveness of the reduction, reuse and recycling efforts within the GTA.

  10. Developing an action concept inventory

    NASA Astrophysics Data System (ADS)

    McGinness, Lachlan P.; Savage, C. M.

    2016-06-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for incorporating expert and student feedback into successive revisions of the ACI. The student feedback, including think-aloud interviews, enabled us to identify their misconceptions about action physics.

  11. Collaborative Action Research: Historical Trends.

    ERIC Educational Resources Information Center

    Smulyan, Lisa

    This paper presents a historical overview of the use of action research in education and describes the basic assumptions and expectations that continue to characterize collaborative research projects today. Action research was initiated in the 1930's by Kurt Lewin and adapted by educators in the 1940's. Interest in action research declined between…

  12. Action Research: Trends and Variations

    ERIC Educational Resources Information Center

    Beaulieu, Rodney J.

    2013-01-01

    Action research continues to grow as a research tradition, yet misconceptions about what it is and is not remains, even among scholars. For example, some mistakenly believe action research is only about professional development and is not a scholarly research approach. Some assume action research must be accomplished through a collaborative…

  13. Programming Tool-Use Actions

    ERIC Educational Resources Information Center

    Massen, Cristina; Prinz, Wolfgang

    2007-01-01

    When humans plan to execute a tool-use action, they can only specify the bodily movement parameters by taking into account the external target or goal of the tool-use action and the target-movement mapping implemented by the tool. In this study, the authors used the movement precuing method to investigate how people prepare for actions made with…

  14. Developing an Action Concept Inventory

    ERIC Educational Resources Information Center

    McGinness, Lachlan P.; Savage, C. M.

    2016-01-01

    We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for…

  15. Rethinking Actions: Implementation and Association

    PubMed Central

    Chatterjee, Anjan

    2015-01-01

    Action processing allows us to move through and interact with the world, as well as understand the movements performed by other people. In recent years, there has been increasing interest in the semantics of actions as differentiated from the semantics of objects. However, as the understanding of action semantics has evolved, it is evident that the existing literature conflates two senses of the word “action”—one that stems from studies of tool use and the other from event representation. In this paper, we suggest that this issue can be clarified by closely examining differences in how the human parietal and temporal cortices of the brain process action-related stimuli. By contrasting the posterior parietal cortex to the posterolateral temporal cortex, we characterize two complementary action systems in the human brain, each with its own specialization of function. We suggest that these two systems be referred to as the parietal Action Implementation System, and the posterolateral temporal Action Association System. While the fronto-parietal system is concerned primarily with how we perform actions, and simulate others’ actions, the temporal action system is more involved with processing actions from a third-person, conceptual standpoint. Recent work in cognitive neuroscience of perception and language, as well as the neuroanatomical organization of these brain regions support this distinction. We will discuss the implications of this work for cognition-, language-, and neuroscience-based action research. PMID:26352170

  16. Action Principle for Relativistic Magnetohydrodynamics

    NASA Astrophysics Data System (ADS)

    D'Avignon, Eric; Morrison, Philip; Pegoraro, Francesco

    2015-11-01

    A covariant action principle for ideal relativistic magnetohydrodynamics in terms of natural Eulerian field variables is given. This is done by generalizing the covariant Poisson bracket theory of Marsden et al., which uses a noncanonical bracket to implement constrained variations of an action functional. Various implications and extensions of this action principle are also discussed.

  17. Motor Execution Affects Action Prediction

    ERIC Educational Resources Information Center

    Springer, Anne; Brandstadter, Simone; Liepelt, Roman; Birngruber, Teresa; Giese, Martin; Mechsner, Franz; Prinz, Wolfgang

    2011-01-01

    Previous studies provided evidence of the claim that the prediction of occluded action involves real-time simulation. We report two experiments that aimed to study how real-time simulation is affected by simultaneous action execution under conditions of full, partial or no overlap between observed and executed actions. This overlap was analysed by…

  18. Action Research in Music Education.

    ERIC Educational Resources Information Center

    Conway, Colleen M.; Borst, James

    2001-01-01

    Provides background information on using action research in music education. Offers guidelines for teachers to help them do action research. Includes an example of how a music teacher conducted action research in which the teacher asked, "Why did [the students] continue vocal music from middle school to high school?" (CMK)

  19. Evolution in Action

    ERIC Educational Resources Information Center

    Dennis, Mike; Duggan, Adrienne; McGregor, Deb

    2014-01-01

    Evolution and inheritance appear in the new National Science Curriculum for England, which comes into effect from September 2014. In the curriculum documents, it is expected that pupils in year 6 (ages 10-11) should be taught to: (1) recognise that living things have changed over time; (2) recognise that living things produce offspring of the same…

  20. Wave action power plant

    SciTech Connect

    Lucia, L.V.

    1982-03-16

    A wave action power plant powered by the action of water waves has a drive shaft rotated by a plurality of drive units, each having a lever pivotally mounted on and extending from said shaft and carrying a weight, in the form of a float, which floats on the waves and rocks the lever up and down on the shaft. A ratchet mechanism causes said shaft to be rotated in one direction by the weight of said float after it has been raised by wave and the wave has passed, leaving said float free to move downwardly by gravity and apply its full weight to pull down on the lever and rotate the drive shaft. There being a large number of said drive units so that there are always some of the weights pulling down on their respective levers while other weights are being lifted by waves and thereby causing continuous rotation of the drive shaft in one direction. The said levers are so mounted that they may be easily raised to bring the weights into a position wherein they are readily accessible for cleaning the bottoms thereof to remove any accumulation of barnacles, mollusks and the like. There is also provided means for preventing the weights from colliding with each other as they independently move up and down on the waves.

  1. Capillary action liquid chromatography.

    PubMed

    Zhang, Bo; Bergström, Edmund T; Goodall, David M; Myers, Peter

    2009-06-01

    Capillary action LC (caLC) is introduced as a technique using capillary action as the driving force to perform LC in capillary columns packed with HPLC type microparticulate materials. A dry packing method with centrifugal force was developed to prepare capillary columns in parallel (10 columns per 3 min) to support their disposable use in caLC. Using a digital microscope for real-time imaging and recording separations of components in a dye mixture, caLC was found to have flow characteristics similar to TLC. Based on the investigation of microparticulate HPLC silica gels of different size (1.5-10 microm) and a typical TLC grade irregular medium, Merck 60G silica, the van Deemter curves suggested molecular diffusion as the major contribution to band broadening in caLC. With Waters Xbridge 2.6 microm silica, plate heights down to 8.8 microm were obtained, comparable to those achievable in HPLC. Assisted by an image-processing method, the visual caLC separation was converted to a classical chromatogram for further data analysis and such a facility confirmed the observation of highly efficient bands.

  2. Age Relationship

    NASA Technical Reports Server (NTRS)

    2006-01-01

    12 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a group of impact craters in Aonia Planum, Mars. Remarkably, two of the craters are approximately equal in size, however, they clearly differ in age. The left (west) crater has a well-defined rim and its ejecta blanket overlies part of the less pronounced crater to its immediate east. The one with the ejecta blanket is younger. Other circular depressions in this bouldery scene are also old, eroded impact craters.

    Location near: 59.5oS, 78.5oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Autumn

  3. Anti-aging cosmetics and its efficacy assessment methods

    NASA Astrophysics Data System (ADS)

    Li, Xiang

    2015-07-01

    The mechanisms of skin aging, the active ingredients used in anti-aging cosmetics and evaluation methods for anti-aging cosmetics were surmised in this paper. And the mechanisms of skin aging were introduced in the intrinsic and extrinsic ways. Meanwhile, the anti-aging cosmetic active ingredients were classified in accordance with the mechanism of action. Various evaluation methods such as human evaluation, in vitro evaluation were also summarized.

  4. Controlling Attention through Action: Observing Actions Primes Action-Related Stimulus Dimensions

    ERIC Educational Resources Information Center

    Fagioli, Sabrina; Ferlazzo, Fabio; Hommel, Bernhard

    2007-01-01

    Previous findings suggest that planning an action "backward-primes" perceptual dimension related to this action: planning a grasp facilitates the processing of visual size information, while planning a reach facilitates the processing of location information. Here we show that dimensional priming of perception through action occurs even in the…

  5. The minimalist grammar of action

    PubMed Central

    Pastra, Katerina; Aloimonos, Yiannis

    2012-01-01

    Language and action have been found to share a common neural basis and in particular a common ‘syntax’, an analogous hierarchical and compositional organization. While language structure analysis has led to the formulation of different grammatical formalisms and associated discriminative or generative computational models, the structure of action is still elusive and so are the related computational models. However, structuring action has important implications on action learning and generalization, in both human cognition research and computation. In this study, we present a biologically inspired generative grammar of action, which employs the structure-building operations and principles of Chomsky's Minimalist Programme as a reference model. In this grammar, action terminals combine hierarchically into temporal sequences of actions of increasing complexity; the actions are bound with the involved tools and affected objects and are governed by certain goals. We show, how the tool role and the affected-object role of an entity within an action drives the derivation of the action syntax in this grammar and controls recursion, merge and move, the latter being mechanisms that manifest themselves not only in human language, but in human action too. PMID:22106430

  6. Antiviral Actions of Interferons

    PubMed Central

    Samuel, Charles E.

    2001-01-01

    Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs. Furthermore, advances made while elucidating the IFN system have contributed significantly to our understanding in multiple areas of virology and molecular cell biology, ranging from pathways of signal transduction to the biochemical mechanisms of transcriptional and translational control to the molecular basis of viral pathogenesis. IFNs are approved therapeutics and have moved from the basic research laboratory to the clinic. Among the IFN-induced proteins important in the antiviral actions of IFNs are the RNA-dependent protein kinase (PKR), the 2′,5′-oligoadenylate synthetase (OAS) and RNase L, and the Mx protein GTPases. Double-stranded RNA plays a central role in modulating protein phosphorylation and RNA degradation catalyzed by the IFN-inducible PKR kinase and the 2′-5′-oligoadenylate-dependent RNase L, respectively, and also in RNA editing by the IFN-inducible RNA-specific adenosine deaminase (ADAR1). IFN also induces a form of inducible nitric oxide synthase (iNOS2) and the major histocompatibility complex class I and II proteins, all of which play important roles in immune response to infections. Several additional genes whose expression profiles are altered in response to IFN treatment and virus infection have been identified by microarray analyses. The availability of cDNA and genomic clones for many of the components of the IFN system, including IFN-α, IFN-β, and IFN-γ, their receptors, Jak and Stat and IRF signal transduction components, and proteins such as PKR, 2′,5′-OAS, Mx, and ADAR, whose expression is regulated by IFNs, has permitted the generation of mutant proteins, cells that overexpress different forms of the proteins, and animals in which their expression has been disrupted by targeted gene disruption. The use of these IFN system

  7. Testing fractional action cosmology

    NASA Astrophysics Data System (ADS)

    Shchigolev, V. K.

    2016-08-01

    The present work deals with a combined test of the so-called Fractional Action Cosmology (FAC) on the example of a specific model obtained by the author earlier. In this model, the effective cosmological term is proportional to the Hubble parameter squared through the so-called kinematic induction. The reason of studying this cosmological model could be explained by its ability to describe two periods of accelerated expansion, that is in agreement with the recent observations and the cosmological inflation paradigm. First of all, we put our model through the theoretical tests, which gives a general conception of the influence of the model parameters on its behavior. Then, we obtain some restrictions on the principal parameters of the model, including the fractional index, by means of the observational data. Finally, the cosmography parameters and the observational data compared to the theoretical predictions are presented both analytically and graphically.

  8. Words and actions.

    PubMed

    Kissling, F

    1999-01-01

    This is an editorial that appeared in the journal Conscience. Church leaders have long employed a rhetoric that stigmatizes those who perform abortions and women who have abortions. According to many men in the Church, women who have abortions are either mindless victims or are devoid of moral sensibility. In addition to treating abortion as if it were murder, church leaders also brand it as evil. With this kind of language coming from the church, British Columbia Catholic editor Paul Schratz's assertion that something positive might come from killing a doctor who has provided an abortion can hardly be seen as aberrant. Presently, the reaction of those engaged in the abortion wars is to reject any notion that their language contributes in any way to murders, injuries, and bombings. But language leads to action and violent rhetoric can engender violent deeds.

  9. The Quench Action

    NASA Astrophysics Data System (ADS)

    Caux, Jean-Sébastien

    2016-06-01

    We give a pedagogical introduction to the methodology of the Quench Action, which is an effective representation for the calculation of time-dependent expectation values of physical operators following a generic out-of-equilibrium state preparation protocol (for example a quantum quench). The representation, originally introduced in Caux and Essler (2013 Phys. Rev. Lett. 110 257203), is founded on a mixture of exact data for overlaps together with variational reasonings. It is argued to be quite generally valid and thermodynamically exact for arbitrary times after the quench (from short times all the way up to the steady state), and applicable to a wide class of physically relevant observables. Here, we introduce the method and its language, give an overview of some recent results, suggest a roadmap and offer some perspectives on possible future research directions.

  10. Taking action against violence.

    PubMed

    Kunz, K

    1996-05-01

    Significant increase in violent crimes in recent years forced Icelandic men to take action against violence. Television was seen as a major contributory factor in increasing violence. Surveys indicate that 10-15 years after television broadcasting commences in a particular society, the incidence of crime can be expected to double. While the majority of the individuals arrested for violent crimes are men, being male does not necessarily mean being violent. The Men's Committee of the Icelandic Equal Rights Council initiated a week-long information and education campaign under the theme "Men Against Violence". This campaign involved several events including an art exhibit, speeches on violence in families, treatment sought by those who are likely to resort to violence, booklet distribution among students in secondary schools, and a mass media campaign to raise public awareness on this pressing problem.

  11. Guam Energy Action Plan

    SciTech Connect

    Conrad, M. D.; Ness, J. E.

    2013-07-01

    Describes the four near-term strategies selected by the Guam Energy Task Force during action planning workshops conducted in March 2013, and outlines the steps being taken to implement those strategies. Each strategy addresses one of the energy sectors identified in the earlier Guam strategic energy plan as being an essential component of diversifying Guam's fuel sources and reducing fossil energy consumption 20% by 2020. The four energy strategies selected are: (1) expanding public outreach on energy efficiency and conservation, (2) establishing a demand-side management revolving loan program, (3) exploring waste-to-energy options, and (4) influencing the transportation sector via anti-idling legislation, vehicle registration fees, and electric vehicles.

  12. Structure learning in action

    PubMed Central

    Braun, Daniel A.; Mehring, Carsten; Wolpert, Daniel M.

    2010-01-01

    ‘Learning to learn’ phenomena have been widely investigated in cognition, perception and more recently also in action. During concept learning tasks, for example, it has been suggested that characteristic features are abstracted from a set of examples with the consequence that learning of similar tasks is facilitated—a process termed ‘learning to learn’. From a computational point of view such an extraction of invariants can be regarded as learning of an underlying structure. Here we review the evidence for structure learning as a ‘learning to learn’ mechanism, especially in sensorimotor control where the motor system has to adapt to variable environments. We review studies demonstrating that common features of variable environments are extracted during sensorimotor learning and exploited for efficient adaptation in novel tasks. We conclude that structure learning plays a fundamental role in skill learning and may underlie the unsurpassed flexibility and adaptability of the motor system. PMID:19720086

  13. An agenda for action.

    PubMed

    1987-01-01

    Participants at the 1985 Maseru Seminar on Another Development for Southern African Development Coordination Conference (SADCC) Countries developed an agenda for action aimed at ending the exploitation of people in the region. Another Development, a concept first introduced into the worldwide debate about economic development in 1975, is based on 5 premises: development should be need-oriented, self-reliant, endogenous, ecologically sound, and based on structural transformations. It should be viewed as an integrated socioeconomic, political, and cultural process. Participants noted that conventional development policies are becoming increasingly incapable of satisfying the basic needs of people in the SADCC region for food, health, housing, education, and employment. The Agenda for Action recognizes that the problems of dependency cannot be solved by the more intensive application of development strategies that created the problems in the first place. Needed, instead, is: 1) effective popular participation in all decision-making processes; 2) the transformation of social structures to facilitate effective participation in decision-making; 3) the full exercise of human rights; 4) the establishment of local, district, and national papers and publishing houses dedicated to the right to be informed; 5) the gearing of agricultural production primarily to the growing of food for domestic markets, with exports limited to surpluses; 6) the production of raw materials for manufactured goods that meet local needs; 7) land reform; 8) the coordinated development of both light and heavy industry and mining, with an emphasis on decentralization of industries to rural areas; 9) the allocation of higher priority to resources for housing; 10) the integration of meaningful productive work into the educational system at every level; 11) the development of an endogenous science and technology base; and 12) the allocation of the resources needed for a primary health care system.

  14. Learning from their own actions: the unique effect of producing actions on infants' action understanding.

    PubMed

    Gerson, Sarah A; Woodward, Amanda L

    2014-01-01

    Prior research suggests that infants' action production affects their action understanding, but little is known about the aspects of motor experience that render these effects. In Study 1, the relative contributions of self-produced (n = 30) and observational (n = 30) action experience on 3-month-old infants' action understanding was assessed using a visual habituation paradigm. In Study 2, generalization of training to a new context was examined (n = 30). Results revealed a unique effect of active over observational experience. Furthermore, findings suggest that benefits of trained actions do not generalize broadly, at least following brief training.

  15. Design Evolution Study - Aging Options

    SciTech Connect

    P. McDaniel

    2002-04-05

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

  16. Everyday robotic action: lessons from human action control

    PubMed Central

    de Kleijn, Roy; Kachergis, George; Hommel, Bernhard

    2014-01-01

    Robots are increasingly capable of performing everyday human activities such as cooking, cleaning, and doing the laundry. This requires the real-time planning and execution of complex, temporally extended sequential actions under high degrees of uncertainty, which provides many challenges to traditional approaches to robot action control. We argue that important lessons in this respect can be learned from research on human action control. We provide a brief overview of available psychological insights into this issue and focus on four principles that we think could be particularly beneficial for robot control: the integration of symbolic and subsymbolic planning of action sequences, the integration of feedforward and feedback control, the clustering of complex actions into subcomponents, and the contextualization of action-control structures through goal representations. PMID:24672474

  17. Everyday robotic action: lessons from human action control.

    PubMed

    de Kleijn, Roy; Kachergis, George; Hommel, Bernhard

    2014-01-01

    Robots are increasingly capable of performing everyday human activities such as cooking, cleaning, and doing the laundry. This requires the real-time planning and execution of complex, temporally extended sequential actions under high degrees of uncertainty, which provides many challenges to traditional approaches to robot action control. We argue that important lessons in this respect can be learned from research on human action control. We provide a brief overview of available psychological insights into this issue and focus on four principles that we think could be particularly beneficial for robot control: the integration of symbolic and subsymbolic planning of action sequences, the integration of feedforward and feedback control, the clustering of complex actions into subcomponents, and the contextualization of action-control structures through goal representations.

  18. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... have occurred, it shall promptly refer the matter to the Department of Justice (DOJ), the HHS Inspector... of the peer review and advisory committee review processes, but may be used by the Secretary...

  19. Rational action selection in 1½- to 3-year-olds following an extended training experience.

    PubMed

    Klossek, Ulrike M H; Dickinson, Anthony

    2012-02-01

    Previous studies failed to find evidence for rational action selection in children under 2 years of age. The current study investigated whether younger children required more training to encode the relevant causal relationships. Children between 1½ and 3 years of age were trained over two sessions to perform actions on a touch-sensitive screen to obtain video clips as outcomes. Subsequently, a visual habituation procedure was employed to devalue one of the training outcomes. As in previous studies, 2- and 3-year-olds chose actions associated with an expected valued outcome significantly more often during a subsequent choice test. Moreover, analysis of children's first responses in the post-devaluation test revealed evidence of rational action selection even in the youngest age group (18-23 months). Consistent with dual-process accounts of action control, the findings support the view that the ability to make rational action choices develops gradually.

  20. The role of hydrogen sulfide in aging and age-related pathologies

    PubMed Central

    Perridon, Bernard W.; Leuvenink, Henri G.D.; Hillebrands, Jan-Luuk; van Goor, Harry; Bos, Eelke M.

    2016-01-01

    When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the ‘hallmarks of aging’. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H2S) in the regulation of aging. Nowadays, H2S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H2S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies. PMID:27683311