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Sample records for aging review committee

  1. External Community Review Committee:

    PubMed Central

    Smith, Maureen A.; Kaufman, Nancy J.; Dearlove, Andrea J.

    2013-01-01

    Background: Major gaps exist between what we know and what we do in clinical practice and community health programs and narrowing this gap will require substantive partnerships between academic researchers and the communities they serve. Objectives: We describe a research pilot award program that makes a unique commitment to community engagement through the addition of an External Community Review Committee to the typical research review process that gives external stakeholders decision-making power over research funding. Methods: Whereas engaging community reviewers in discussion and rating of research proposals is not novel, the ICTR ECRC review process is distinct in that it is subsequent to peer review and uses different criteria and methodology. This method of engagement allows for the community review panel to re-rank scientifically meritorious proposals—such that proposals funded do not necessarily follow the rank order from scientific peer review. The approach taken by UW ICTR differs from those discussed in the literature that present a model of community-academic co-review. Results: This article provides guidance for others interested in this model of community engagement and reviews insights gained during the evolution of this strategy; including how we addressed conflict, how the committee was able to change the pilot award program over time, and individual roles that were crucial to the success of this approach. Conclusions: The advantages of this approach include success through traditional academic metrics while achieving an innovative shared-power mechanism for community engagement which we believe is critical for narrowing the gap between knowledge and practice.

  2. 43 CFR 10.16 - Review committee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Review committee. 10.16 Section 10.16... REPATRIATION REGULATIONS General § 10.16 Review committee. (a) General. The Review Committee will advise... recommendation, finding, report, or other action of the Review Committee is advisory only and not binding on...

  3. 43 CFR 10.16 - Review committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Review committee. 10.16 Section 10.16... REPATRIATION REGULATIONS General § 10.16 Review committee. (a) General. The Review Committee will advise... recommendation, finding, report, or other action of the Review Committee is advisory only and not binding on...

  4. The functions of human subjects review committees.

    PubMed

    Gray, B H

    1977-08-01

    After summarizing the literature on the functioning of committees set up to review research involving human subjects, the author describes three latent or emerging functions of these committees. These include using the committees to protect institutions, to judge proposed research in terms of possible social policy impact, and to consider proposed research from the standpoint of "community acceptability". The author expresses concern about the possible politicization of review committee decisions.

  5. Basic Education Program Review Committee Annual Report.

    ERIC Educational Resources Information Center

    Tennessee State Board of Education, 2004

    2004-01-01

    In the effort to improve essential components of the Basic Education Program (BEP), the General Assembly has adopted legislation directing the BEP Review Committee to perform a comprehensive review of the funding formula, identifying needed revisions, additions, or deletions. This year, through a series of full-day meetings, the committee has…

  6. MHD technology transfer, integration, and review committee

    NASA Astrophysics Data System (ADS)

    1990-05-01

    As part of Task 8 of the magnetohydrodynamic (MHD) Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The TTIRC consists of an Executive Committee (EC) which acts as the governing body, and a General Committee (GC), also referred to as the main or full committee, consisting of representatives from the various POC contractors, participating universities and national laboratories, utilities, equipment suppliers, and other potential MHD users or investors. The purpose of the TTIRC is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the U.S. MHD Program. There are seven sections: introduction; Executive Committee and General Committee activity; Committee activities related to technology transfer; ongoing POC integration activities being performed under the auspices of the Executive Committee; recommendations passed on to the DOE by the Executive Committee; Planned activities for the next six months.

  7. MHD Technology Transfer, Integration and Review Committee

    SciTech Connect

    Not Available

    1992-01-01

    This fifth semi-annual status report of the MHD Technology Transfer, Integration, and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1990 through September 1990. It includes summaries and minutes of committee meetings, progress summaries of ongoing Proof-of-Concept (POC) contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months.

  8. Regional Infant and Child Mortality Review Committee 2013 final report.

    PubMed

    Wilson, Ann L; Sideras, Jim

    2015-02-01

    The Regional Infant and Child Review Committee serves 10 counties in southeastern South Dakota and its mission is to review of deaths of infants and children under the age of 18 so that information can be transformed into action to protect young lives. In 2013, the committee's interdisciplinary team reviewed 32 deaths that met its criteria. The manner of 13 of these deaths was natural, nine accidental, one homicide, five suicide, and four undetermined. There were five infant deaths during sleep and each of these occurred in an unsafe sleep environment. The number of suicides in 2013 was considerably higher than the typical one death by suicide that previously has been observed per year in the area. The report provides the Committee's recommendations for community action that could prevent future deaths of infants and children. PMID:25799635

  9. Regional Infant and Child Mortality Review Committee--2011 final report.

    PubMed

    Wilson, Ann L; Sideras, James

    2012-12-01

    The 2011 annual report of the Regional Infant and Child Mortality Review Committee (RICMRC) is presented. Since 1997, the committee has reviewed 224 deaths to achieve its mission to "review infant and child deaths so that information can be transformed into action to protect young lives." In 2011, the committee reviewed 21 deaths (22 met the committee's criteria) of infants and children who were residents of Minnehaha, Turner, Lincoln, Hanson and Brookings counties in South Dakota. The manner of 12 of the reviewed deaths was natural with eight of these the result of progressive neurological diseases or conditions. In 2011 there were no deaths attributed to Sudden Infant Death Syndrome (SIDS), though there were two deaths of infants during sleep. One of these infants was ruled accidental as the baby died of aspiration and the other death occurred in an unsafe environment with its manner determined to be undecided. Six deaths were accidental, one of which occurred as a result of a fire in a home without functional smoke alarms. One motor vehicle death occurred, through no fault of the teen age driver. Another death resulted from tubing over a low head dam on the Big Sioux River. One youth suicide occurred to a resident of the region. PMID:23477038

  10. 45 CFR 601.4 - Classification Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CLASSIFICATION AND DECLASSIFICATION OF NATIONAL SECURITY INFORMATION § 601.4 Classification Review Committee. The Security Officer (Information) chairs the Foundation's Classification Review Committee which has...

  11. 76 FR 3674 - Guidelines for the Supervisory Review Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ..., entitled ``Supervisory Review Committee'' (IRPS 95-1). 60 FR 14795 (March 20, 1995). Through IRPS 95- 1... Committee's review process at a later date. 60 FR 14795, 14796 (March 20, 1995). In 2002, the Board...

  12. 29 CFR 14.3 - DOL Classification Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true DOL Classification Review Committee. 14.3 Section 14.3 Labor... Classification Review Committee. A DOL Classification Review Committee is hereby established. (a) Composition of... under the Freedom of Information Act, 5 U.S.C. 552, when a proposed denial is based on...

  13. MHD Technology Transfer, Integration and Review Committee

    SciTech Connect

    Not Available

    1989-10-01

    As part of the MHD Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The Charter of the TTIRC, which was approved by the DOE in June 1988 and distributed to the committee members, is included as part of this Summary. As stated in the Charter, the purpose of this committee is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the US MHD Program. The DOE fiscal year 1989 MHD Program Plan Schedule is included at the end of this Summary. The MHD Technology Transfer, Integration and Review Committee's activities to date have focused primarily on the technology transfer'' aspects of its charter. It has provided a forum for the dissemination of technical and programmatic information among workers in the field of MHD and to the potential end users, the utilities, by holding semi-annual meetings. The committee publishes this semi-annual report, which presents in Sections 2 through 11 capsule summaries of technical progress for all DOE Proof-of-Concept MHD contracts and major test facilities.

  14. Pulsed Power Peer Review Committee Report

    SciTech Connect

    BLOOMQUIST,DOUGLAS D.

    2000-12-01

    In 1993, the Government Performance and Results Act (GPRA, PL 103-62) was enacted. GPRA, which applies to all federal programs, has three components: strategic plans, annual performance plans, and metrics to show how well annual plans are being followed. As part of meeting the GRPA requirement in FY2000, a 14-member external peer review panel (the Garwin Committee) was convened on May 17-19, 2000 to review Sandia National Laboratories' Pulsed Power Programs as a component of the Performance Appraisal Process negotiated with the Department of Energy (DOE). The scope of the review included activities in inertial confinement fission (ICF), weapon physics, development of radiation sources for weapons effects simulation, x-ray radiography, basic research in high energy density physics (HEDP), and pulsed power technology research and development. In his charge to the committee, Jeffrey Quintenz, Director of Pulsed Power Sciences (1600) asked that the review be based on four criteria (1) quality of science, technology, and engineering, (2) programmatic performance, management, and planning, (3) relevance to national needs and agency missions, and (4) performance in the operation and construction of major research facilities. In addition, specific programmatic questions were posed by the director and by the DOE-Defense Programs (DP). The accompanying report, produced as a SAND document, is the report of the committee's findings.

  15. 32 CFR 2400.41 - Office Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Committee. The Office of Science and Technology Policy Review Committee (hereinafter referred to as the... material originated or held by the Office of Science and Technology Policy. The Office Review Committee... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY...

  16. 32 CFR 2400.41 - Office Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Committee. The Office of Science and Technology Policy Review Committee (hereinafter referred to as the... material originated or held by the Office of Science and Technology Policy. The Office Review Committee... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY...

  17. 32 CFR 2400.41 - Office Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Committee. The Office of Science and Technology Policy Review Committee (hereinafter referred to as the... material originated or held by the Office of Science and Technology Policy. The Office Review Committee... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY...

  18. 32 CFR 2400.41 - Office Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Committee. The Office of Science and Technology Policy Review Committee (hereinafter referred to as the... material originated or held by the Office of Science and Technology Policy. The Office Review Committee... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY...

  19. 32 CFR 2400.41 - Office Review Committee.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Committee. The Office of Science and Technology Policy Review Committee (hereinafter referred to as the... material originated or held by the Office of Science and Technology Policy. The Office Review Committee... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY...

  20. Pulsed power peer review committee report.

    SciTech Connect

    Not Available

    2004-08-01

    As part of meeting the GRPA (Government Performance and Results Act) requirements and to provide input to Sandia's annual Performance Evaluation Assessment Report (PEAR) to the National Nuclear Security Administration in FY2004, a 14-member external review committee chaired by Dr. Alvin Trivelpiece was convened by Sandia National Laboratories (SNL) on May 4-6, 2004 to review Sandia National Laboratories' Pulsed Power Programs. The scope of the review included activities in high energy density physics (HEDP), inertial confinement fusion (ICF), radiation/weapon physics, the petawatt laser initiative (PW) and fast ignition, equation-of state studies, radiation effects science and lethality, x-ray radiography, ZR development, basic research and pulsed power technology research and development, as well as electromagnetics and work for others. In his charge to the Committee, Dr. Jeffrey P. Quintenz, Director of Pulsed Power Sciences (Org. 1600) asked that the evaluation and feedback be based on three criteria: (1) quality of technical activities in science, technology, and engineering, (2) programmatic performance, management, and planning, and (3) relevance to national needs and agency missions. In addition, the director posed specific programmatic questions. The accompanying report, produced as a SAND document, is the report of the Committee's finding.

  1. 32 CFR 2103.52 - Classification Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS TO IMPLEMENT E.O. 12065-INCLUDING PROCEDURES FOR PUBLIC ACCESS TO DOCUMENTS THAT MAY BE DECLASSIFIED Implementation and Review § 2103.52 Classification Review Committee. The NSC Classification Review... 32 National Defense 6 2011-07-01 2011-07-01 false Classification Review Committee. 2103.52...

  2. 32 CFR 2103.52 - Classification Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS TO IMPLEMENT E.O. 12065-INCLUDING PROCEDURES FOR PUBLIC ACCESS TO DOCUMENTS THAT MAY BE DECLASSIFIED Implementation and Review § 2103.52 Classification Review Committee. The NSC Classification Review... 32 National Defense 6 2010-07-01 2010-07-01 false Classification Review Committee. 2103.52...

  3. The structure and functioning of ethical review committees.

    PubMed

    Gutteridge, F; Bankowski, Z; Curran, W; Dunne, J

    1982-01-01

    This overview of ethics committees for biomedical and behavioral research considers principal issues in the role and operation of these committees in various countries. It suggests general guidelines derived from a literature review and from a survey of existing committees by the Council for International Organizations of Medical Sciences. Aspects of present practice discussed are the governance and authority of ethics committees, the scope of activities subject to review, committee size and composition, and special concerns in review. These concerns include informed consent, risk/benefit assessment, qualifications of investigators, research design, selection of subjects, privacy, and compensation for injury.

  4. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  5. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Information Security Review Committee. 8.9 Section.../DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established a Department of Transportation Information Security Review...

  6. 42 CFR 61.7 - Review of applications; committees; awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Review of applications; committees; awards. 61.7 Section 61.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.7 Review of applications; committees; awards....

  7. 42 CFR 61.7 - Review of applications; committees; awards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Review of applications; committees; awards. 61.7 Section 61.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.7 Review of applications; committees; awards....

  8. 42 CFR 61.7 - Review of applications; committees; awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Review of applications; committees; awards. 61.7 Section 61.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.7 Review of applications; committees; awards....

  9. 42 CFR 61.7 - Review of applications; committees; awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Review of applications; committees; awards. 61.7 Section 61.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.7 Review of applications; committees; awards....

  10. 42 CFR 61.7 - Review of applications; committees; awards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Review of applications; committees; awards. 61.7 Section 61.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.7 Review of applications; committees; awards....

  11. 49 CFR 8.9 - Information Security Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Information Security Review Committee. 8.9 Section 8.9 Transportation Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.9 Information Security Review Committee. (a) There is hereby established...

  12. 76 FR 23871 - Guidelines for the Supervisory Review Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ..., entitled ``Supervisory Review Committee'' (IRPS 95-1). 60 FR 14795 (March 20, 1995). Through IRPS 95- 1... Committee's review process at a later date. 60 FR 14795, 14796 (March 20, 1995). In 2002, the Board amended... IRPS At its January meeting, the NCUA Board issued interim final IRPS 11-1. 76 FR 3674 (January...

  13. 75 FR 13140 - Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Nomination... Repatriation Review Committee; Notice of Nomination Solicitation. The National Park Service is soliciting nominations for one member of the Native American Graves Protection and Repatriation Review Committee....

  14. Joint Integration Office Independent Review Committee annual report, 1985

    SciTech Connect

    Not Available

    1986-08-01

    Comprised of seven persons with extensive experience in the issues of nuclear waste, the Independent Review Committee (IRC) provides independent and objective review of Defense Transuranic Waste Program (DTWP) activities managed by the Joint Integration Office (JIO), formerly the Defense Transuranic Waste Lead Organization (TLO). The Committee is ensured a broad, interdisciplinary perspective since its membership includes representatives from the fields of nuclear engineering, nuclear waste transportation, industrial quality control, systems and environmental engineering and state and local government. The scope of IRC activities includes overall review of specific TLO plans, projects and activities, and technical review of particular research and development projects. The Committee makes specific suggestions and recommendations based upon expertise in the field of TRU Waste Management. The IRC operates as a consulting group, under an independent charter providing objective review of program activities. This report summarizes the 12 major topics reviewed by the committee during 1985.

  15. 15 CFR 2002.1 - Trade Policy Committee Review Group.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Executive Director of the Council on International Economic Policy. The Special Representative or the Deputy... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Trade Policy Committee Review Group... OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE OPERATION OF COMMITTEES § 2002.1 Trade Policy...

  16. 5 CFR 1312.12 - Security Program Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Security Program Review Committee. 1312.12 Section 1312.12 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES... Committee, which will act on suggestions and complaints about the OMB security program....

  17. Social Security Disability Reviews: The Human Costs. Hearing before the Special Committee on Aging. United States Senate, Ninety-Eighth Congress, Second Session (Part 1 - Chicago, Illinois).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document provides transcripts of witness testimony and prepared statements from the first of three Congressional hearings called to examine at the local level the administration of the social security disability review program. Following the opening statements of Senators John Heinz and Charles H. Percy, testimonies are presented from three…

  18. 45 CFR 601.4 - Classification Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ....4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Security Officer (Information) chairs the Foundation's Classification Review Committee which has authority to act on all suggestions and complaints with respect to the Foundation's administration of...

  19. 45 CFR 601.4 - Classification Review Committee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Security Officer (Information) chairs the Foundation's Classification Review Committee which has authority to act on all suggestions and complaints with respect to the Foundation's administration of...

  20. 45 CFR 601.4 - Classification Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Security Officer (Information) chairs the Foundation's Classification Review Committee which has authority to act on all suggestions and complaints with respect to the Foundation's administration of...

  1. 45 CFR 601.4 - Classification Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... Security Officer (Information) chairs the Foundation's Classification Review Committee which has authority to act on all suggestions and complaints with respect to the Foundation's administration of...

  2. Recurring themes arising during medical research ethics committee review.

    PubMed

    Kelleher, E; Stanton, A; Vale, G; Smith, D

    2013-06-01

    A standard application form for the ethical review of health-related research studies has recently been adopted by many Irish medical research ethics committees. In order to assess the impact of the new form, we reviewed all comments made by the Beaumont Hospital Ethics Committee during two six-month periods, immediately prior to adoption of the new form (2010), and soon afterwards (2011). Neither volume nor comment type differed significantly between the two observation periods. Participant documentation (information leaflets and consent forms) accounted for the largest proportion of comments (2010; 44%, 2011; 37%). Other common areas prompting queries were study administration (7%), design (12%) and procedures (13%), participant selection and recruitmen (8%), and lastly data protection (9%). Because of these findings, the standard operating procedures of the committee have been revised--use of provided template participant documentation is strongly encouraged, and a "Recurring Review Themes" checklist is highlighted to all applicants.

  3. Dry aging of beef; Review.

    PubMed

    Dashdorj, Dashmaa; Tripathi, Vinay Kumar; Cho, Soohyun; Kim, Younghoon; Hwang, Inho

    2016-01-01

    The present review has mainly focused on the specific parameters including aging (aging days, temperature, relative humidity, and air flow), eating quality (flavor, tenderness and juiciness), microbiological quality and economic (shrinkage, retail yields and cost) involved beef dry aging process. Dry aging is the process where beef carcasses or primal cuts are hanged and aged for 28 to 55 d under controlling environment conditions in a refrigerated room with 0° to 4 °C and with relative humidity of 75 to 80 %. However there are various opinions on dry aging procedures and purveyors of such products are passionate about their programs. Recently, there has been an increased interest in dry aging process by a wider array of purveyors and retailers in the many countries. Dry aging process is very costly because of high aging shrinkage (6 to15 %), trims loss (3 to 24 %), risk of contamination and the requirement of highest grades meat with. The packaging in highly moisture-permeable bag may positively impact on safety, quality and shelf stability of dry aged beef. The key effect of dry aging is the concentration of the flavor that can only be described as "dry-aged beef". But the contribution of flavor compounds of proteolysis and lipolysis to the cooked dry aged beef flavor is not fully known. Also there are limited scientific studies of aging parameters on the quality and palatability of dry aged beef. PMID:27200180

  4. Spent nuclear fuel Canister Storage Building CDR Review Committee report

    SciTech Connect

    Dana, W.P.

    1995-12-01

    The Canister Storage Building (CSB) is a subproject under the Spent Nuclear Fuels Major System Acquisition. This subproject is necessary to design and construct a facility capable of providing dry storage of repackaged spent fuels received from K Basins. The CSB project completed a Conceptual Design Report (CDR) implementing current project requirements. A Design Review Committee was established to review the CDR. This document is the final report summarizing that review

  5. Medicare: Catastrophic Illness Insurance. Briefing Report to the Chairman, Special Committee on Aging, U.S. Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Program Evaluation and Methodology Div.

    In response to a request by Senator John Melcher of the United States Senate Special Committee on Aging, the General Accounting Office (GAO) reviewed legislative proposals designed to protect Medicare enrollees from the financial hardships that often accompany catastrophic illness. The GAO originally examined six legislative proposals introduced…

  6. Medicare: Comparison of Catastrophic Health Insurance Proposals. Briefing Report to the Chairman, Select Committee on Aging, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of Human Resources.

    In response to a request from the chairman of the Congressional Select Committee on Aging, the General Accounting Office (GAO) investigated the potential effects of legislative proposals to provide catastrophic coverage to Medicare beneficiaries on beneficiaries' out-of-pocket health care expenses. The GAO reviewed GAO and other reports to…

  7. Centers for manufacturing technology: Industrial Advisory Committee Review

    SciTech Connect

    1995-10-01

    An advisory committee, composed of senior managers form industrial- sector companies and major manufacturing trade associations and representatives from appropriate educational institutions, meets semi-annually to review and advise the Oak Ridge Centers for Manufacturing Technology (ORCMT) on its economic security program. Individual papers have been indexed separately for the database.

  8. 15 CFR 2008.19 - Classification Review Committee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE...

  9. 15 CFR 2008.19 - Classification Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE...

  10. 15 CFR 2008.19 - Classification Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE...

  11. 15 CFR 2008.19 - Classification Review Committee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE...

  12. 15 CFR 2008.19 - Classification Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE...

  13. Regional Infant and Child Mortality Review Committee--2012 final report.

    PubMed

    Wilson, Ann L; Sideras, Jim

    2013-10-01

    The 2012 annual report of the Regional Infant and Child Mortality Review Committee (RICMRC) is presented. With its mission to "review infant and child deaths so that information can be transformed into action to protect young lives," the Committee has reviewed 341 deaths in South Eastern South Dakota since its inception in 1997. In 2012, 24 deaths of children who were residents of Minnehaha, Brookings, McCook, Moody and Union counties met the criteria and all were reviewed by the interdisciplinary membership of the Committee. The manner of 10 of these deaths was natural, six of which were the outcome of congenital or long term illnesses and four deaths were sudden and unexpected. There were no sudden infant death syndrome (SIDS) deaths in 2012, though there were four deaths of infants that occurred during sleep. One of these deaths was considered natural, the manner of two was considered undetermined and one accidental. In each of these four cases there were hazards in the sleep environment of the infant who died. Overall, there were 10 deaths due to accidents and this included one incident in which three children died in a house fire. Similar to previous years, there was one suicidal and one homicidal death of a child. The report provides data on trends in infant and child deaths for this region of South Dakota and provides the Committee's recommendations of community action that could prevent their future occurrence. PMID:24244981

  14. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  15. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  16. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  17. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  18. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  19. 75 FR 65030 - Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation AGENCY: National Park Service, Interior. ACTION: Native American Graves Protection and... nominations for two members of the Native American Graves Protection and Repatriation Review Committee....

  20. 77 FR 65406 - Native American Graves Protection and Repatriation Review Committee: Notice of Nomination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Notice of Nomination Solicitation AGENCY: National Park Service, Interior. ACTION: Notice of nomination solicitation... Protection and Repatriation Review Committee, National NAGPRA Program, National Park Service, 1201 Eye...

  1. 77 FR 65407 - Native American Graves Protection and Repatriation Review Committee: Notice of Nomination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Notice of Nomination Solicitation AGENCY: National Park Service, Interior. ACTION: Notice of Nomination Solicitation... American Graves Protection and Repatriation Review Committee, National NAGPRA Program, National...

  2. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 5. Summary - Piping Review Committee conclusions and recommendations

    SciTech Connect

    Not Available

    1985-04-01

    This document summarizes a comprehensive review of NRC requirements for Nuclear Piping by the US NRC Piping Review Committee. Four topical areas, addressed in greater detail in Volumes 1 through 4 of this report, are included: (1) Stress Corrosion Cracking in Piping of Boiling Water Reactor Plants; (2) Evaluation of Seismic Design; (3) Evaluation of Potential for Pipe Breaks; and (4) Evaluation of Other Dynamic Loads and Load Combinations. This volume summarizes the major issues, reviews the interfaces, and presents the Committee's conclusions and recommendations for updating NRC requirements on these issues. This report also suggests research or other work that may be required to respond to issues not amenable to resolution at this time.

  3. 10 CFR 7.20 - Conflict of interest reviews of advisory committee members' outside interests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Conflict of interest reviews of advisory committee members' outside interests. 7.20 Section 7.20 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.20 Conflict of interest reviews of advisory committee members' outside interests. The Designated...

  4. 10 CFR 7.20 - Conflict of interest reviews of advisory committee members' outside interests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Conflict of interest reviews of advisory committee members' outside interests. 7.20 Section 7.20 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.20 Conflict of interest reviews of advisory committee members' outside interests. The Designated...

  5. 10 CFR 7.20 - Conflict of interest reviews of advisory committee members' outside interests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Conflict of interest reviews of advisory committee members' outside interests. 7.20 Section 7.20 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.20 Conflict of interest reviews of advisory committee members' outside interests. The Designated...

  6. 10 CFR 7.20 - Conflict of interest reviews of advisory committee members' outside interests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Conflict of interest reviews of advisory committee members' outside interests. 7.20 Section 7.20 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.20 Conflict of interest reviews of advisory committee members' outside interests. The Designated...

  7. 10 CFR 7.20 - Conflict of interest reviews of advisory committee members' outside interests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Conflict of interest reviews of advisory committee members' outside interests. 7.20 Section 7.20 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.20 Conflict of interest reviews of advisory committee members' outside interests. The Designated...

  8. Resilience in aging: literature review.

    PubMed

    Fontes, Arlete Portella; Neri, Anita Liberalesso

    2015-05-01

    Psychological resilience is comprised of an adaptive functioning standard before the current and accumulated risks of life. Furthermore, it has a comprehensive range of psychological resources which are essential to overcome adversities, such as personal competences, self-beliefs and interpersonal control which interact with the social networks support. The objectives are to show the concepts of psychological resilience in elderly, relative to dominant theoretical models and the main data about psychological resilience in aging, found in an international and Brazilian review from 2007 to 2013. The descriptors "resilience, psychological resilience and aging", "resiliência e envelhecimento, velhice e velho", were used in PubMed, PsychInfo, SciELO and Pepsic databases. Fifty three international and eleven national articles were selected. The international articles were classified in four categories: psychological and social coping resources, emotional regulation before stressing experiences, successful resilience and aging and correlates, and resilience measures. The Brazilian articles were grouped in three: psychological and social resources, resilience in carers and theory review. Articles on psychological resources and on emotional regulation prevailed as key factors associated with psychological resilience in aging. PMID:26017950

  9. Resilience in aging: literature review.

    PubMed

    Fontes, Arlete Portella; Neri, Anita Liberalesso

    2015-05-01

    Psychological resilience is comprised of an adaptive functioning standard before the current and accumulated risks of life. Furthermore, it has a comprehensive range of psychological resources which are essential to overcome adversities, such as personal competences, self-beliefs and interpersonal control which interact with the social networks support. The objectives are to show the concepts of psychological resilience in elderly, relative to dominant theoretical models and the main data about psychological resilience in aging, found in an international and Brazilian review from 2007 to 2013. The descriptors "resilience, psychological resilience and aging", "resiliência e envelhecimento, velhice e velho", were used in PubMed, PsychInfo, SciELO and Pepsic databases. Fifty three international and eleven national articles were selected. The international articles were classified in four categories: psychological and social coping resources, emotional regulation before stressing experiences, successful resilience and aging and correlates, and resilience measures. The Brazilian articles were grouped in three: psychological and social resources, resilience in carers and theory review. Articles on psychological resources and on emotional regulation prevailed as key factors associated with psychological resilience in aging.

  10. Transportation in an aging society: improving mobility and safety for older persons. Volume 1. Committee report and recommendations. Special report

    SciTech Connect

    Not Available

    1988-01-01

    In June 1986, the Transportation Research Board began a project to investigate the needs and problems of older Americans in relation to the U.S. roadway-transportation system. A committee of experts was appointed to review the design and operational features of the roadway system and to recommend steps to improve the mobility and safety of older users--drivers, passengers, pedestrians--who are an integral part of the system. The committees found that people over the age of 75 are involved in more fatal crashes than any other group except teenagers. Nevertheless they decided that 'age alone is a poor predictor of the performance of any individual.' Rather than restricting licenses at any given maximum age, the committee recommended that highway safety be improved by making adjustments to the design of highway features and that license screening tests be adapted to better identify people of all ages who have impairments that would affect driving. The committee also recommended improved specialized transportation for the frail elderly.

  11. Lapse in Institutional Animal Care and Use Committee Continuing Reviews.

    PubMed

    Tsan, Min-Fu; Grabenbauer, Michael; Nguyen, Yen

    2016-01-01

    The United States federal animal welfare regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals require that institutional animal care and use committees (IACUCs) conduct continuing reviews of all animal research activities. However, little is known about the lapse rate of IACUC continuing reviews, and how frequently investigators continue research activities during the lapse. It is also not clear what factors may contribute to an institution's lapse in IACUC continuing reviews. As part of the quality assurance program, the Department of Veterans Affairs (VA) has collected performance metric data for animal care and use programs since 2011. We analyzed IACUC continuing review performance data at 74-75 VA research facilities from 2011 through 2015. The IACUC continuing review lapse rates improved from 5.6% in 2011 to 2.7% in 2015. The rate of investigators continuing research activities during the lapse also decreased from 47.2% in 2012 to 7.4% in 2015. The type of IACUCs used and the size of animal research programs appeared to have no effect in facility's rates of lapse in IACUC continuing reviews. While approximately 80% of facilities reported no lapse in IACUC continuing reviews, approximately 14% of facilities had lapse rates of >10% each year. Some facilities appeared to be repeat offenders. Four facilities had IACUC lapse rates of >10% in at least 3 out of 5 years, suggesting a system problem in these facilities requiring remedial actions to improve their IACUC continuing review processes. PMID:27606820

  12. President's Committee on Mental Retardation: A Historical Review 1966-1985.

    ERIC Educational Resources Information Center

    Krause, Fred J.

    Recommendations of the President's Committee on Mental Retardation to encourage collaboration among government, voluntary, individual, community, and private sector efforts are reported in this publication which presents a historical review of the Committee from 1966 through 1986. The background and establishment of the Committee are discussed in…

  13. 78 FR 16295 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... the Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American... the Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native...

  14. 78 FR 21410 - Native American Graves Protection and Repatriation Review Committee: Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meetings AGENCY... Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves... Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves...

  15. 77 FR 74874 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a telephonic meeting of the Native American... Advisory Committee Act, 5 U.S.C. Appendix (1988), of a telephonic meeting of the Native American...

  16. 76 FR 54730 - Committees on Administration and Management, Collaborative Governance, Judicial Review, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... Governance, Judicial Review, and Regulation ACTION: Notice of public meetings. SUMMARY: Notice is hereby..., from 2 to 5 p.m. Designated Federal Officer: Scott Rafferty. Committee on Collaborative Governance The Committee on Collaborative Governance will meet to consider two projects. The committee will...

  17. Lapse in Institutional Animal Care and Use Committee Continuing Reviews

    PubMed Central

    Tsan, Min-Fu; Grabenbauer, Michael; Nguyen, Yen

    2016-01-01

    The United States federal animal welfare regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals require that institutional animal care and use committees (IACUCs) conduct continuing reviews of all animal research activities. However, little is known about the lapse rate of IACUC continuing reviews, and how frequently investigators continue research activities during the lapse. It is also not clear what factors may contribute to an institution’s lapse in IACUC continuing reviews. As part of the quality assurance program, the Department of Veterans Affairs (VA) has collected performance metric data for animal care and use programs since 2011. We analyzed IACUC continuing review performance data at 74–75 VA research facilities from 2011 through 2015. The IACUC continuing review lapse rates improved from 5.6% in 2011 to 2.7% in 2015. The rate of investigators continuing research activities during the lapse also decreased from 47.2% in 2012 to 7.4% in 2015. The type of IACUCs used and the size of animal research programs appeared to have no effect in facility’s rates of lapse in IACUC continuing reviews. While approximately 80% of facilities reported no lapse in IACUC continuing reviews, approximately 14% of facilities had lapse rates of >10% each year. Some facilities appeared to be repeat offenders. Four facilities had IACUC lapse rates of >10% in at least 3 out of 5 years, suggesting a system problem in these facilities requiring remedial actions to improve their IACUC continuing review processes. PMID:27606820

  18. 1978 Age Discrimination Act Amendments. Explanation of 1978 Age Discrimination Act Amendments. Report of Committee on Conference, Including Text of H.R. 5383. Text of Age Discrimination Act, as Amended. Report of House Labor Committee. Report of Senate Human Resources Committee. Union Labor Report No. 1596, Special Supplement, Part 2.

    ERIC Educational Resources Information Center

    Bureau of National Affairs, Inc., Washington, DC.

    This booklet explains and reproduces the text of the 1978 amendments to the Age Discrimination in Employment Act (ADEA). It also gives the actual committee on conference report as well as reports of the House labor committee and the Senate human resources committee. In its introductory explanation, the booklet discusses the most publicized…

  19. Age Discrimination: Quality of Enforcement. Hearing before the Select Committee on Aging. House of Representatives, One Hundredth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    The text of a Congressional hearing exploring whether there is validity to complaints that the Equal Employment Opportunity Commission (EEOC) is not adequately and effectively enforcing the protections of the Age Discrimination in Employment Act is presented in this document. The document begins with the opening statement of committee chairman…

  20. Invited review: aging and human temperature regulation.

    PubMed

    Kenney, W Larry; Munce, Thayne A

    2003-12-01

    This mini-review focuses on the effects of aging on human temperature regulation. Although comprehensive reviews have been published on this topic (Kenney WL. Exercise and Sport Sciences Reviews, Baltimore: Williams & Wilkins, 1997, p. 41-76; Pandolf KB. Exp Aging Res 17: 189-204, 1991; Van Someren EJ, Raymann RJ, Scherder EJ, Daanen HA, and Swaab DF. Ageing Res Rev 1: 721-778, 2002; and Young AJ. Exp Aging Res 17: 205-213, 1991), this mini-review concisely summarizes the present state of knowledge about human temperature regulation and aging in thermoneutral conditions, as well as during hypo- and hyperthermic challenges. First, we discuss age-related effects on baseline body core temperature and phasing rhythms of the circadian temperature cycle. We then examine the altered physiological responses to cold stress that result from aging, including attenuated peripheral vasoconstriction and reduced cold-induced metabolic heat production. Finally, we present the age-related changes in sweating and cardiovascular function associated with heat stress. Although epidemiological evidence of increased mortality among older adults from hypo- and hyperthermia exists, this outcome does not reflect an inability to thermoregulate with advanced age. In fact, studies that have attempted to separate the effects of chronological age from concurrent factors, such as fitness level, body composition, and the effects of chronic disease, have shown that thermal tolerance appears to be minimally compromised by age.

  1. 15 CFR 10.4 - Establishment of the Standard Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... THE DEVELOPMENT OF VOLUNTARY PRODUCT STANDARDS § 10.4 Establishment of the Standard Review Committee... of producers, distributors, and users or consumers of product for which a standard is sought or any... shall be required to approve any actions taken by the committee except for the action of recommending...

  2. 76 FR 12132 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American Graves Protection and... the Interior, as required by law, in order to effect the agreed-upon disposition of Native...

  3. 77 FR 7180 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves Protection... of Native American human remains determined to be culturally unidentifiable; presentations by...

  4. 76 FR 69282 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American Graves Protection and... effect the agreed-upon disposition of Native American human remains determined to be...

  5. 75 FR 9429 - Native American Graves Protection and Repatriation Review Committee: Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meetings AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of three meetings of the Native American Graves... agreement, of Native American human remains determined to be culturally unidentifiable; and presentations...

  6. Review of wire chamber aging

    SciTech Connect

    Va'Vra, J.

    1986-02-01

    This paper makes an overview of the wire chamber aging problems as a function of various chamber design parameters. It emphasizes the chemistry point of view and many examples are drawn from the plasma chemistry field as a guidance for a possible effort in the wire chamber field. The paper emphasizes the necessity of variable tuning, the importance of purity of the wire chamber environment, as well as it provides a practical list of presently known recommendations. In addition, several models of the wire chamber aging are qualitatively discussed. The paper is based on a summary talk given at the Wire Chamber Aging Workshop held at LBL, Berkeley on January 16-17, 1986. Presented also at Wire Chamber Conference, Vienna, February 25-28, 1986. 74 refs., 18 figs., 11 tabs.

  7. Integer Linear Programming for Constrained Multi-Aspect Committee Review Assignment.

    PubMed

    Karimzadehgan, Maryam; Zhai, Chengxiang

    2012-07-01

    Automatic review assignment can significantly improve the productivity of many people such as conference organizers, journal editors and grant administrators. A general setup of the review assignment problem involves assigning a set of reviewers on a committee to a set of documents to be reviewed under the constraint of review quota so that the reviewers assigned to a document can collectively cover multiple topic aspects of the document. No previous work has addressed such a setup of committee review assignments while also considering matching multiple aspects of topics and expertise. In this paper, we tackle the problem of committee review assignment with multi-aspect expertise matching by casting it as an integer linear programming problem. The proposed algorithm can naturally accommodate any probabilistic or deterministic method for modeling multiple aspects to automate committee review assignments. Evaluation using a multi-aspect review assignment test set constructed using ACM SIGIR publications shows that the proposed algorithm is effective and efficient for committee review assignments based on multi-aspect expertise matching.

  8. NSF Geosciences Initiatives and Plans Reviewed at Advisory Committee Meeting

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2010-10-01

    In its semiannual meeting on 6-7 October, the U.S. National Science Foundation's (NSF) Advisory Committee for Geosciences (GEO) reviewed GEO initiatives, programs, and plans, including the GEO directorate's fast and significant response to support research related to various aspects of the Deepwater Horizon oil spill in the Gulf of Mexico through Rapid Response Research (RAPID) awards and other measures. An undercurrent during the meeting was concern about workload stress among GEO staff. Assistant director of geosciences Tim Killeen noted that the proposed budget for fiscal year (FY) 2011, which began on 1 October, would increase directorate funding 7.4% over FY 2010, if the budget is approved by Congress. A continuing resolution in Congress maintains FY 2010 funding levels until at least 3 December. Killeen said NSF's budget request for FY 2012 has been submitted to the White House Office of Management and Budget, adding that although he cannot discuss details of that budget yet, GEO Vision, a long­range strategy document for the directorate released in October 2009, “is reflected in our thinking going forward.”

  9. 28 CFR 541.7 - Unit Discipline Committee (UDC) review of the incident report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., 28 CFR part 542, subpart B. ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Unit Discipline Committee (UDC) review of... JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Inmate Discipline...

  10. 28 CFR 541.7 - Unit Discipline Committee (UDC) review of the incident report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., 28 CFR part 542, subpart B. ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Unit Discipline Committee (UDC) review of... JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Inmate Discipline...

  11. 28 CFR 541.7 - Unit Discipline Committee (UDC) review of the incident report.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., 28 CFR part 542, subpart B. ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Unit Discipline Committee (UDC) review of... JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Inmate Discipline...

  12. 28 CFR 541.7 - Unit Discipline Committee (UDC) review of the incident report.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., 28 CFR part 542, subpart B. ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Unit Discipline Committee (UDC) review of... JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Inmate Discipline...

  13. 76 FR 18144 - Committees on Administration & Management, Collaborative Governance, and Judicial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Governance, and Judicial Review ACTION: Notice of public meetings. SUMMARY: Notice is hereby given of public... Collaborative Governance The Committee on Collaborative Governance will meet to discuss a draft...

  14. Report of the DOE Review Committee on the baseline validation of the Superconducting Super Collider

    SciTech Connect

    Not Available

    1993-08-01

    The Secretary of Energy directed that an independent review of the current cost and schedule baseline for the SSC be conducted. The purpose of this independent review was to validate the current cost and schedule baseline and to ensure that the project status is accurate as currently reported. Through May 1993, approximately $1.5 billion of the baseline cost of $8.249 billion had been expended, with project completion forecasted on the baseline schedule as of September 1999. This report documents the findings of the SSC Baseline Validation Review Committee (the Committee). The report is organized into five parts. The first section is the Executive Summary. This introduction is followed by a discussion of the project progress/status as determined by the Committee. The next section describes the Committee`s estimate of the cost at completion for the SSC project, followed by an assessment of the adequacy of the business management systems currently being used to manage the project. The final section presents the Committee`s conclusions and recommendations. The main body of the report is followed by the subcommittee reports and appendices.

  15. Committees

    NASA Astrophysics Data System (ADS)

    Williams, Gwyn P.; Revesz, Peter; Arp, Uwe

    2014-03-01

    Conference Chairs NameOrganization Gwyn Williams Jefferson Lab Peter ReveszCornell High Energy Synchrotron Source Uwe ArpSynchrotron Ultraviolet Radiation Facility Programme Committee NameOrganization Alastair MacDowellAdvanced Light Source Tom ToellnerAdvanced Photon Source Amitava D RoyCenter for Advanced Microstructures and Devices Tom EllisCanadian Light Source Roberta SantarosaLaboratório Nacional de Luz Síncrotron Jerry (Jerome) HastingsLinac Coherent Light Source Steven HulbertNational Synchrotron Light Source Thomas A RabedeauStanford Synchrotron Radiation Lightsource Mark BissenSynchrotron Radiation Center Gwyn WilliamsJefferson Lab Peter ReveszCornell High Energy Synchrotron Source Uwe ArpSynchrotron Ultraviolet Radiation Facility

  16. [White House Conference on Aging, 1981. Creating an Age Integrated Society: Implications for the Media. Report and Executive Summary of the Technical Committee.

    ERIC Educational Resources Information Center

    Tanenbaum, Marc H.; And Others

    The relationship of older Americans to the new media culture of society is the focus of this Technical Committee Report. The work of two committee-appointed subcommittees on stereotypes and new media technology are explained with a special emphasis on the influence of television. Age stereotyping is examined in prime time television, daytime…

  17. Committees

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  18. Committees

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  19. Annual Review of Editorial Committee Activities in Power and Energy Society, IEE of Japan

    NASA Astrophysics Data System (ADS)

    Editorial Committee Of Power; Energy Society

    The Editorial Committee is working in planning and editing of the publication of Power and Energy Society. In this article, activities of the committee of the last term are reported, and recent trend and future problems are also discussed. The process of planning and editing of the publication, and the challenges to reduce the necessary months for reviewing papers and to increase the number of submitted papers are shown.

  20. 77 FR 32004 - Guidelines for the Supervisory Review Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    .... 309(a), 108 Stat. 2160 (1994); 60 FR 14795 (Mar. 20, 1995). Through IRPS 95-1, NCUA established a... supervisory determinations credit unions may appeal to the Committee. 78 FR 19778 (Apr. 23, 2002). In order to... Board combined IRPS 95-1 and 02-1 into IRPS 11-1. 83 FR 23871 (Apr. 29, 2011). In December 2011,...

  1. 78 FR 55064 - First Responder Network Authority Board Special Review Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... Review Committee. SUMMARY: The First Responder Network Authority (FirstNet) Board Special ] Review... ``FirstNet.'' Due to the limited number of ports, attendance via teleconference will be on a first-come, first-served basis. FOR FURTHER INFORMATION CONTACT: Uzoma Onyeije, Secretary, FirstNet, U.S....

  2. 42 CFR 61.15 - Moral character or loyalty; reference to Special Review Committee; review and recommendation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Moral character or loyalty; reference to Special Review Committee; review and recommendation. 61.15 Section 61.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular...

  3. 42 CFR 61.15 - Moral character or loyalty; reference to Special Review Committee; review and recommendation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Moral character or loyalty; reference to Special Review Committee; review and recommendation. 61.15 Section 61.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular...

  4. 42 CFR 61.15 - Moral character or loyalty; reference to Special Review Committee; review and recommendation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Moral character or loyalty; reference to Special Review Committee; review and recommendation. 61.15 Section 61.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular...

  5. 42 CFR 61.15 - Moral character or loyalty; reference to Special Review Committee; review and recommendation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Moral character or loyalty; reference to Special Review Committee; review and recommendation. 61.15 Section 61.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular...

  6. 42 CFR 61.15 - Moral character or loyalty; reference to Special Review Committee; review and recommendation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Moral character or loyalty; reference to Special Review Committee; review and recommendation. 61.15 Section 61.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular...

  7. Aging and Synaptic Plasticity: A Review

    PubMed Central

    Bergado, Jorge A.; Almaguer, William

    2002-01-01

    Aging affects all systems, but the brain seems to be particularly vulnerable to the action of negative, age-dependent factors. A gradual loss of memory functions is one of the earliest and most widespread consequences of brain aging. The causes for such impairment are still unclear. Long-term potentiation (LTP) is one form of neural plasticity, which has been proposed as the cellular correlate for memory. LTP is affected by aging, and such alteration might be causally related to memory dysfunction. In the present paper, we review the evidence sustaining the existence of a causal link between cognitive and LTP impairments, as well as the possible mechanisms involved. New results indicate a possible involvement of a deficient reinforcement of LTP by affective influences. PMID:12959152

  8. Aging and the Body: A Review*

    PubMed Central

    Clarke, Laura Hurd; Korotchenko, Alexandra

    2014-01-01

    In this article, we examine the existing sociocultural research and theory concerned with the aging body. In particular, we review the body image and embodiment literatures and discuss what is known about how older adults perceive and experience their aging bodies. We analyse how body image is shaped by age, culture, ethnicity, gender, health status, sexual preference, and social class. Additionally, we critically elucidate the embodiment literature as it pertains to illness experiences, sexuality, the everyday management of the aging body, appearance work, and embodied identity. By outlining the key findings, theoretical debates, and substantive discrepancies within the body image and embodiment research and theory, we identify gaps in the literature and forecast future, much-needed avenues of investigation. PMID:24976674

  9. Advisory committee on immunization practices recommended immunization schedule for adults aged 19 years or older--United States, 2015.

    PubMed

    Kim, David K; Bridges, Carolyn B; Harriman, Kathleen H

    2015-02-01

    In October 2014, the Advisory Committee on Immunization Practices (ACIP) approved the Recommended Immunization Schedule for Adults Aged 19 Years or Older, United States, 2015. This schedule provides a summary of ACIP recommendations for the use of vaccines routinely recommended for adults aged 19 years or older in two figures, footnotes for each vaccine, and a table that describes primary contraindications and precautions for commonly used vaccines for adults. Changes in the 2015 adult immunization schedule from the 2014 schedule included the August 2014 recommendation for routine administration of the 13-valent pneumococcal conjugate vaccine (PCV13) in series with the 23-valent pneumococcal polysaccharide vaccine (PPSV23) for all adults aged 65 years or older, the August 2014 revision on contraindications and precautions for the live attenuated influenza vaccine (LAIV), and the October 2014 approval by the Food and Drug Administration to expand the approved age for use of recombinant influenza vaccine (RIV). These revisions were also reviewed and approved by the American College of Physicians, American Academy of Family Physicians, American College of Obstetricians and Gynecologists, and American College of Nurse-Midwives.

  10. Aging and Family Life: A Decade Review

    PubMed Central

    Silverstein, Merril; Giarrusso, Roseann

    2010-01-01

    In this review, we summarize and critically evaluate the major empirical, conceptual, and theoretical directions that studies of aging families have taken during the first decade of the 21st century. The field has benefited from an expanded perspective based on four overarching themes: (a) complexity in emotional relations, (b) diversity in family structures and households, (c) interdependence of family roles and functions, and (d) patterns and outcomes of caregiving. Although research on aging families has advanced theory and applied innovative statistical techniques, the literature has fallen short in fully representing diverse populations and in applying the broadest set of methodological tools available. We discuss these and other frontier areas of scholarship in light of the aging of baby boomers and their families. PMID:22930600

  11. Social Security Disability Reviews: The Human Costs. Joint Hearing before the Subcommittee on Social Security of the Committee on Ways and Means, House of Representatives and the Special Committee on Aging, United States Senate, Ninety-Eighth Congress, Second Session (Part 3 - Hot Springs, Arkansas).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document provides transcripts of witness testimony and prepared statements from the third of three Congressional hearings called to examine at the local level the administration of the social security disability review program. Opening statements are presented from Representatives J. J. Pickle and Beryl Anthony, Jr., and Senator Daniel Pryor.…

  12. 40 CFR 105.12 - How is the awards review committee selected?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 22 2011-07-01 2011-07-01 false How is the awards review committee selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards...

  13. 40 CFR 105.12 - How is the awards review committee selected?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false How is the awards review committee selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards...

  14. Norwalk Community College AA-AS Degree Review Committee Curriculum Report, August 21, 1989.

    ERIC Educational Resources Information Center

    Pennino, Eileen M.; Luster, Gwen Tolliver

    In an attempt to revitalize and reform its curriculum, the Associate of Arts-Associate of Science (AA-AS) Degree Review Committee (DRC) of Connecticut's Norwalk Community College issued a curriculum report proposing a 21 credit, limited distributive core for the AS degree (which accounts for 80% of the college's degree recipients). This proposal…

  15. Preparing for a Successful Psychiatry Residency Review Committee Site Visit: A Guide for New Training Directors

    ERIC Educational Resources Information Center

    Bhatia, Shashi K.; Bhatia, Subhash C.

    2005-01-01

    Objective: New residency training directors are often faced with multiple competing tasks such as meeting Accreditation Council for Graduate Medical Education (ACGME) Psychiatry Program Requirements and achieving successful completion of residency review committee (RRC) site visits. For many years, the authors have presented workshops on this…

  16. 75 FR 17953 - Native American Graves Protection and Repatriation Review Committee Findings Related to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... to the Identity of Cultural Items in the Possession of the American Museum of Natural History, New... made findings of fact related to the identity of 45 cultural items in the possession of the American... NAGPRA Working Group, to request from the Review Committee findings of fact on the identity, by...

  17. Advisory committee on immunization practices recommended immunization schedules for persons aged 0 through 18 years--United States, 2015.

    PubMed

    Strikas, Raymond A

    2015-02-01

    Each year, the Advisory Committee on Immunization Practices (ACIP) reviews the recommended immunization schedules for persons aged 0 through 18 years to ensure that the schedules reflect current recommendations for Food and Drug Administration-licensed vaccines. In October 2014, ACIP approved the recommended immunization schedules for persons aged 0 through 18 years for 2015, which include several changes from the 2014 immunization schedules. For 2015, the figures, footnotes, and tables are being published on the CDC immunization schedule website (http://www.cdc.gov/vaccines/schedules/index.html). This provides readers electronic access to the most current version of the schedules and footnotes on the CDC website. Health care providers are advised to use figures, tables, and the combined footnotes together. Printable versions of the 2015 immunization schedules for persons aged 0 through 18 years also are available at the website in several formats, including portrait, landscape, and pocket-sized versions. Ordering instructions for laminated versions and "parent-friendly" schedules also are available at the immunization schedule website.

  18. Advisory Committee on Immunization Practices Recommended Immunization Schedules for Persons Aged 0 Through 18 Years--United States, 2016.

    PubMed

    Robinson, Candice L

    2016-02-05

    Each year, the Advisory Committee on Immunization Practices (ACIP)* reviews the recommended immunization schedules for persons aged 0 through 18 years to ensure that the schedules reflect current recommendations for Food and Drug Administration-licensed vaccines. In October 2015, ACIP approved the recommended immunization schedules for persons aged 0 through 18 years for 2016; the 2016 schedules include several changes from the 2015 immunization schedules. For 2016, the figures, footnotes, and tables will be published on the CDC immunization schedule website (http://www.cdc.gov/vaccines/schedules/index.html). This provides readers electronic access to the most current version of the schedules and footnotes on the CDC website. Health care providers are advised to use figures, tables, and the combined footnotes together. Printable versions of the 2016 immunization schedules for persons aged 0 through 18 years in several formats (e.g., portrait, landscape, and pocket-sized versions) and ordering instructions for laminated versions and "parent-friendly" schedules are available at the immunization schedule website.

  19. MHD Technology Transfer, Integration and Review Committee. Second semiannual status report, July 1988--March 1989

    SciTech Connect

    Not Available

    1989-10-01

    As part of the MHD Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The Charter of the TTIRC, which was approved by the DOE in June 1988 and distributed to the committee members, is included as part of this Summary. As stated in the Charter, the purpose of this committee is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the US MHD Program. The DOE fiscal year 1989 MHD Program Plan Schedule is included at the end of this Summary. The MHD Technology Transfer, Integration and Review Committee`s activities to date have focused primarily on the ``technology transfer`` aspects of its charter. It has provided a forum for the dissemination of technical and programmatic information among workers in the field of MHD and to the potential end users, the utilities, by holding semi-annual meetings. The committee publishes this semi-annual report, which presents in Sections 2 through 11 capsule summaries of technical progress for all DOE Proof-of-Concept MHD contracts and major test facilities.

  20. Review of the Fusion Theory and Computing Program. Fusion Energy Sciences Advisory Committee (FESAC)

    SciTech Connect

    Antonsen, Thomas M.; Berry, Lee A.; Brown, Michael R.; Dahlburg, Jill P.; Davidson, Ronald C.; Greenwald, Martin; Hegna, Chris C.; McCurdy, William; Newman, David E.; Pellegrini, Claudio; Phillips, Cynthia K.; Post, Douglass E.; Rosenbluth, Marshall N.; Sheffield, John; Simonen, Thomas C.; Van Dam, James

    2001-08-01

    At the November 14-15, 2000, meeting of the Fusion Energy Sciences Advisory Committee, a Panel was set up to address questions about the Theory and Computing program, posed in a charge from the Office of Fusion Energy Sciences (see Appendix A). This area was of theory and computing/simulations had been considered in the FESAC Knoxville meeting of 1999 and in the deliberations of the Integrated Program Planning Activity (IPPA) in 2000. A National Research Council committee provided a detailed review of the scientific quality of the fusion energy sciences program, including theory and computing, in 2000.

  1. Fingerprint composition and aging: A literature review.

    PubMed

    Cadd, Samuel; Islam, Meez; Manson, Peter; Bleay, Stephen

    2015-07-01

    Fingerprints have a key role in criminal investigations and are the most commonly used form of evidence worldwide. Significant gaps remain however, in the understanding of fingerprint chemistry, including enhancement reaction mechanisms and the effect of environmental variables and time on composition. Determining the age of a fingerprint is also a relatively unexplored area. A successful method, with reliable and quantitative estimates, would have numerous advantages. Previous unreliable methods have predominantly focused on enhancement success based on physical and chemical changes. This review explores variations in composition due to donor characteristics and environmental variables, and identifies gaps for further research. We also present a qualitative and quantitative summary of the effect of time on composition. Kinetics are presented where known, with summary schematics for reaction mechanisms. Previous studies exploring methods for determining the age of a fingerprint are also discussed, including their advantages and disadvantages. Lastly we propose a potentially more accurate and reliable methodology for determining fingerprint age based on quantitative kinetic changes to the composition of a fingerprint over time.

  2. 76 FR 34703 - Human Studies Review Board Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... research (71 FR 24 6138) that called for creating a new, independent human studies review board (i.e., HSRB... shall fully disclose, among other financial interests, the candidate's employment, stocks and bonds, and..., EPA will evaluate each candidate to assess whether there is any conflict of financial...

  3. Promoting Successful Cognitive Aging: A Comprehensive Review

    PubMed Central

    Daffner, Kirk R.

    2010-01-01

    Promoting successful cognitive aging is a topic of major importance to individuals and the field of public health. This review presents a coherent framework not only for evaluating factors, protective activities, and enhancing agents that have already been proposed, but also ones that will be put forward in the future. The promotion of successful cognitive aging involves the dual goals of preventing loss of information processing capacity and cognitive reserve, and enhancing brain capacity and cognitive reserve. Four major lines of evidence are available for evaluating whether a proposed factor promotes successful cognitive aging: 1) epidemiologic/cohort studies; 2) animal/basic science studies; 3) human “proof-of-concept” studies; and 4) human intervention studies. Each line of evidence has advantages and limitations that will be discussed. Through illustrative examples, we trace the ways in which each method informs us about the potential value of several proposed factors. Currently, lines of converging evidence allow the strongest case to be made for physical and cognitively stimulating activities. Although epidemiological data seem to favor the use of statins to lower the risk of dementia, more definitive recommendations await further randomized controlled studies. There is presently no clear evidence that antioxidants or Ginkgo biloba promote successful cognitive aging. The impact of resveratrol, fish oil, and a long list of other proposed agents needs to be determined. Clinicians remain well-positioned to identify and aggressively treat vascular risk factors, diabetes, sleep disorders, and other conditions that may reduce brain capacity, and to encourage activities that can build cognitive reserve. PMID:20308777

  4. Report of the National Ignition Facility Target Physics Program Review Committee

    SciTech Connect

    Moses, E.

    2000-05-02

    The Department of Energy's (DOE) National Ignition Facility (NIF) has been under construction at the Lawrence Livermore National Laboratory (LLNL) since 1997. This multiple-beam facility is designed to be a source of powerful focused laser light pulses for experiments in support of the nuclear weapons Stockpile Stewardship Program (SSP), NIF will be operated by LLNL as national facility to elucidate high energy density science important to the weapons SSP and to achieving inertial confinement fusion (ICF) ignition. In addition, it will provide the nation with a valuable tool for exploring basic high energy density science. In September of 1999, projected cost overruns and schedule delays were identified in the NIF project, which have necessitated development of new construction and deployment plans and schedules. These affect science programs planned for NIF and DOE programs that the NIF is meant to support. The NIF Programs Review Committee (PRC) requested a review from this Committee of the impact of current NIF plans on the DOE SSP. The charge to the Committee is included in Appendix 1. The Committee was specifically asked to: (1) Review the current plans for the DOE Defense Programs Campaigns use of the NIF with emphasis on how to maximize the utility of the NIF to the SSP. (2) Assess the importance and timeliness to the weapons program of the planned experiments, particularly during NIF's ramp up phase. (3) Judge the overall impact of the new deployment options on the probability of the campaigns attaining their stated goals in the broadest sense. (4) Review ways of mitigating the impacts of delays, such as expanding the use of other facilities before and during the ramp up phase of the NIF, and minimizing the ''learning curve'' for use of the NIF. (5) Review the recent progress in ignition target physics, new ignition designs with potentially higher yield, and the utility of experiments in preparation for ignition before the facility has all 192 beams

  5. Decision Making and the IACUC: Part 1- Protocol Information Discussed at Full-Committee Reviews.

    PubMed

    Silverman, Jerald; Lidz, Charles W; Clayfield, Jonathan C; Murray, Alexandra; Simon, Lorna J; Rondeau, Richard G

    2015-07-01

    IACUC protocols can be reviewed by either the full committee or designated members. Both review methods use the principles of the 3 Rs (reduce, refine, replace) as the overarching paradigm, with federal regulations and policies providing more detailed guidance. The primary goal of this study was to determine the frequency of topics discussed by IACUC during full-committee reviews and whether the topics included those required for consideration by IACUC (for example, pain and distress, number of animals used, availability of alternatives, skill and experience of researchers). We recorded and transcribed 87 protocol discussions undergoing full-committee review at 10 academic institutions. Each transcript was coded to capture the key concepts of the discussion and analyzed for the frequency of the codes mentioned. Pain and distress was the code mentioned most often, followed by the specific procedures performed, the study design, and the completeness of the protocol form. Infrequently mentioned topics were alternatives to animal use or painful or distressful procedures, the importance of the research, and preliminary data. Not all of the topics required to be considered by the IACUC were openly discussed for all protocols, and many of the discussions were limited in their depth. PMID:26224439

  6. A New Ethical Challenge for Institutional Review Boards (IRBs)/Ethics Committees (ECs) in the Assessment of Pediatric Clinical Trials

    PubMed Central

    Rose, Klaus; Kummer, Hans

    2015-01-01

    Both the US and EU have introduced pediatric pharmaceutical legislation to facilitate clinical trials in children and development of better medicines for children. The first concerns were published in 2014 that the European Medicines Agency (EMA)’s Pediatric Committee (PDCO) may be over-enthusiastic and has compelled questionable pediatric clinical trials from pharmaceutical companies. Numerous clinical trials are mandated in rare conditions for which not enough patients exist for even one trial. Furthermore, where these trials are mandated in adolescent patients, the legal age limit of the 18th birthday is confused with a medical age limit and can result in separate clinical trials in adolescent patients that neither make medical nor scientific sense nor will ever recruit enough patients for a meaningful outcome. To confirm our concerns we searched the registry clinicaltrials.gov and found examples for PDCO-triggered unethical trials. We conclude that such trials should not be accepted by institutional review boards (IRBs)/ethics committees (ECs) and that clinical trials resulting from negotiations with EMA’s PDCO need extra careful scrutiny by IRBs/ECs in order to prevent unethical studies and damage to pediatric research and unnecessary risks to pediatric patients. PMID:27417359

  7. A New Ethical Challenge for Institutional Review Boards (IRBs)/Ethics Committees (ECs) in the Assessment of Pediatric Clinical Trials.

    PubMed

    Rose, Klaus; Kummer, Hans

    2015-05-28

    Both the US and EU have introduced pediatric pharmaceutical legislation to facilitate clinical trials in children and development of better medicines for children. The first concerns were published in 2014 that the European Medicines Agency (EMA)'s Pediatric Committee (PDCO) may be over-enthusiastic and has compelled questionable pediatric clinical trials from pharmaceutical companies. Numerous clinical trials are mandated in rare conditions for which not enough patients exist for even one trial. Furthermore, where these trials are mandated in adolescent patients, the legal age limit of the 18th birthday is confused with a medical age limit and can result in separate clinical trials in adolescent patients that neither make medical nor scientific sense nor will ever recruit enough patients for a meaningful outcome. To confirm our concerns we searched the registry clinicaltrials.gov and found examples for PDCO-triggered unethical trials. We conclude that such trials should not be accepted by institutional review boards (IRBs)/ethics committees (ECs) and that clinical trials resulting from negotiations with EMA's PDCO need extra careful scrutiny by IRBs/ECs in order to prevent unethical studies and damage to pediatric research and unnecessary risks to pediatric patients.

  8. E-recruitment based clinical research: notes for Research Ethics Committees/Institutional Review Boards.

    PubMed

    Refolo, P; Sacchini, D; Minacori, R; Daloiso, V; Spagnolo, A G

    2015-01-01

    Patient recruitment is a critical point of today's clinical research. Several proposals have been made for improving it, but the effectiveness of these measures is actually uncertain. The use of Internet (e-recruitment) could represent a great chance to improve patient enrolment, even though the effectiveness of this implementation is not so evident. E-recruitment could bring some advantages, such as better interaction between clinical research demand and clinical research supply, time and resources optimization, and reduction of data entry errors. It raises some issues too, such as sampling errors, validity of informed consent, and protection of privacy. Research Ethics Committees/Institutional Review Boards should consider these critical points. The paper deals with Internet recruitment for clinical research. It also attempts to provide Research Ethics Committees/Institutional Review Boards with notes for assessing e-recruitment based clinical protocols.

  9. Developments in Aging: 1974 and January-April 1975. A Report of the Special Committee on Aging. United States Senate Pursuant to S. Res. 267, March 1, 1974.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    The Special Committee on Aging, established in 1961 by Senate Resolution 33, Eighty-seventh Congress, was charged with making a full and complete study and investigation of problems and opportunities of older people, including problems and opportunities of maintaining health, of assuring adequate income, of finding employment, of engaging in…

  10. Developments in Aging: 1986. Volume 1. A Report of the Special Committee on Aging. United States Senate, One Hundredth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document is the first volume of a two-volume Senate report describing actions taken during 1986 by the Congress, the administration, and the Senate Special Committee on Aging which are significant to older Americans. It summarizes and analyzes federal policies and programs that are of continuing importance for older persons and their…

  11. Proceedings of RIKEN BNL Research Center Workshop, Volume 91, RBRC Scientific Review Committee Meeting

    SciTech Connect

    Samios,N.P.

    2008-11-17

    The ninth evaluation of the RIKEN BNL Research Center (RBRC) took place on Nov. 17-18, 2008, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Dr. Wit Busza (Chair), Dr. Miklos Gyulassy, Dr. Akira Masaike, Dr. Richard Milner, Dr. Alfred Mueller, and Dr. Akira Ukawa. We are pleased that Dr. Yasushige Yano, the Director of the Nishina Institute of RIKEN, Japan participated in this meeting both in informing the committee of the activities of the Nishina Institute and the role of RBRC and as an observer of this review. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on his/her research efforts. This encompassed three major areas of investigation, theoretical, experimental and computational physics. In addition the committee met privately with the fellows and postdocs to ascertain their opinions and concerns. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.

  12. Research Review: A Review of the "President's Committee on the Arts and the Humanities, Reinvesting in Arts Education: Winning America's Future through Creative Schools"

    ERIC Educational Resources Information Center

    Serig, Dan

    2011-01-01

    This article presents the author's review of the "President's Committee on the Arts and the Humanities, Reinvesting in Arts Education: Winning America's Future Through Creative Schools." In May 2011, the President's Committee on the Arts and the Humanities (PCAH) released a report calling for a reinvestment by communities and schools in arts…

  13. Best practices: The Administrative Review Committee at New Hampshire Hospital: a one-year follow-up.

    PubMed

    de Nesnera, Alexander; Folks, David G

    2012-06-01

    New Hampshire Hospital implemented an Administrative Review Committee (ARC), a best practice that provides a risk management process to mitigate potential liability for the hospital and clinicians treating high-profile, high-risk patients. This column reports on the first year of the ARC's operation, during which the committee reviewed 206 patients. The authors describe four patient groups and their distinguishing characteristics. The ARC is accepted by clinicians as an important venue to present high-risk clinical cases and to obtain risk management guidance and consultation. The committee has become an integral part of the hospital culture.

  14. 76 FR 24890 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Biological Aging Review Committee. Date: June 1..., PhD, Scientific Review Officer, Scientific Review Branch, National Institute on Aging, Gateway...

  15. DOE Advanced Scientific Computing Advisory Committee (ASCAC) Report: Exascale Computing Initiative Review

    SciTech Connect

    Reed, Daniel; Berzins, Martin; Pennington, Robert; Sarkar, Vivek; Taylor, Valerie

    2015-08-01

    On November 19, 2014, the Advanced Scientific Computing Advisory Committee (ASCAC) was charged with reviewing the Department of Energy’s conceptual design for the Exascale Computing Initiative (ECI). In particular, this included assessing whether there are significant gaps in the ECI plan or areas that need to be given priority or extra management attention. Given the breadth and depth of previous reviews of the technical challenges inherent in exascale system design and deployment, the subcommittee focused its assessment on organizational and management issues, considering technical issues only as they informed organizational or management priorities and structures. This report presents the observations and recommendations of the subcommittee.

  16. Purple Level - 1 Milestone Review Committee I/O and Archive Follow-up Demonstration

    SciTech Connect

    Gary, M R

    2006-12-05

    On July 7th 2006, the Purple Level-1 Review Committee convened and was presented with evidence of the completion of Level-2 Milestone 461 (Deploy First Phase of I/O Infrastructure for Purple) which was performed in direct support of the Purple Level-1 milestone. This evidence included a short presentation and the formal documentation of milestone No.461 (see UCRL-TR-217288). Following the meeting, the Committee asked for the following additional evidence: (1) Set a speed measurement/goal/target assuming a number of files that the user needs to get into the archives. Then redo the benchmark using whatever tool(s) the labs prefer (HTAR, for example). Document how long the process takes. (2) Develop a test to read files back to confirm that what the user gets out of the archive is what the user put into the archive. This evidence has been collected and is presented here.

  17. COMMITTEES COMMITTEES

    NASA Astrophysics Data System (ADS)

    2010-11-01

    ORGANISING COMMITTEE Chairman: Alexander G Petrov Director, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia, Bulgaria Chairman Emeritus: Nikolay Kirov Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia, Bulgaria Local Organising Committee: Chairman: Alexander G Petrov Members: Diana Nesheva, Doriana Dimova-Malinovska, Eleonora Popova, Lyubomila Dedinska, Christo Popov, Vasil Lovchinov, Marina Primatarowa, Emilia Vlaikova, Irina Velkova, Hassan Chamati PROGRAMME COMMITTEE Chairman: A G Petrov Members: D Alexandrov (Thunder Bay), V Celebonovic (Belgrade), D Dimova-Malinovska (Sofia), B Dulmet (Besancon), A Grechnikov (Moscow), M Gunes (Mugla), C Main (Dundee), D Nesheva (Sofia), M C Petty (Durham), M Popescu (Bucharest), S Reynolds (Dundee), K Shimakawa (Gifu), J Singh (Darwin), N Starbov (Sofia), M Tomilin (St Petersburg), Ph Vanderbemden (Liege), A Vaseashta (Washington) LOCAL SCIENTIFIC COUNCIL Chairman: A G Petrov Members: Bulgarian Academy of Sciences N Sabotinov (President) I Nedkov (Scientific Secretary, Physics) Institute of Solid State Physics N Kirov, D Nesheva, V Lovchinov, St Andreev, M Primatarowa Institute of Electronics R Enikov (Director) Central Lab. of Solar Energy and New Energy Sources D Dimova-Malinovska Institute of Optical Materials and Technologies V Saynov, N Starbov Central Lab. of Applied Physics R Kakanakov (Director) Sofia University - Faculty of Physics A Andreeva, S Russev (Heads of Departments)

  18. Alzheimer's Disease and Related Dementias. Hearing before the Subcommittee on Aging of the Committee on Labor and Human Resources. United States Senate, Ninety-Ninth Congress, Second Session on Review of Health Care Services Available for People with Alzheimer's Disease and Related Dementia and To Review Proposals Related to the Treatment of Alzheimer's Disease.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    A Senate hearing reviewing health care services available for people with Alzheimer's disease and related dementia and reviewing proposals related to the treatment of Alzheimer's disease is presented in this document. Statements are given by Senators Charles E. Grassley, Albert Gore, Paula Hawkins, Howard M. Metzenbaum, Larry Pressler, and Paul…

  19. Exploring the relationship between faculty, students, and the Social and Behavioral Ethics Review Committee through action research.

    PubMed

    Griebling, Susan; Zayas, Vilma Reyes; Borders, Christy; Moore, Elizabeth; Sokol, Ashley; Brydon-Miller, Mary; Gerlach, Julie; Norman, Claudia

    2009-06-01

    STUDENT RESEARCHERS USED ACTION research both to study the relationship between university researchers and the ethics committee, and also to explore the ethics committee's approach to protocols involving action research and other qualitative methods. We review the existing literature on relationships between university faculty and their ethics committees and briefly discuss the basic tenets of action research. We then describe our research process and the specific recommendations that resulted from this work. Finally, we consider the ways in which action research can be used to better understand and address institutional problems through effective collaboration and dialogue.

  20. MHD Technology Transfer, Integration and Review Committee. Fifth semi-annual status report, April 1990--September 1990

    SciTech Connect

    Not Available

    1992-01-01

    This fifth semi-annual status report of the MHD Technology Transfer, Integration, and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1990 through September 1990. It includes summaries and minutes of committee meetings, progress summaries of ongoing Proof-of-Concept (POC) contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months.

  1. An original resolution authorizing expenditures by the Special Committee on Aging.

    THOMAS, 112th Congress

    Sen. Kohl, Herb [D-WI

    2011-02-15

    02/15/2011 Referred to the Committee on Rules and Administration. (text of measure as introduced: CR S757) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. An Appraisal of the Second Year and Recommended Activities and Strategies of the National Advisory and Review Committee.

    ERIC Educational Resources Information Center

    Gipson, Constance F.

    The report is a review and analysis of the status of the Public Service Occupations Curriculum Project, and is an outgrowth of discussions and recommendations from the February 1974 meeting of the National Advisory and Review Committee of the California State Department of Education, Vocational Education Section. Approximately one-half of the…

  3. Redefining Book Reviews for the Digital Age

    ERIC Educational Resources Information Center

    Butler, Deirdre; Leahy, Margaret; McCormack, Ciaran

    2010-01-01

    This paper describes the results of a pilot study conducted in Ireland to examine the effectiveness of an online book review project. The project focused on the production of book reviews by primary school children in the form of digital video. The videos created were uploaded to a password protected website, which was available to the schools…

  4. 78 FR 51195 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Biological Aging Review Committee Date: October... Nakhai, Ph.D., Scientific Review Branch, National Institute On Aging, Gateway Bldg., 2C212,...

  5. Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older--United States, 2016.

    PubMed

    Kim, David K; Bridges, Carolyn B; Harriman, Kathleen H

    2016-02-05

    In October 2015, the Advisory Committee on Immunization Practices (ACIP)* approved the Recommended Immunization Schedule for Adults Aged 19 Years or Older, United States, 2016. This schedule provides a summary of ACIP recommendations for the use of vaccines routinely recommended for adults aged 19 years or older in two figures, footnotes for each vaccine, and a table that describes primary contraindications and precautions for commonly used vaccines for adults. Although the figures in the adult immunization schedule illustrate recommended vaccinations that begin at age 19 years, the footnotes contain information on vaccines that are recommended for adults that may begin at age younger than age 19 years. The footnotes also contain vaccine dosing, intervals between doses, and other important information and should be read with the figures.

  6. Environmental restoration and waste management department independent safety review committee program management plan

    SciTech Connect

    Not Available

    1992-10-01

    This Program Management Plan (PMP) describes and governs the Independent Safety Review Committee (ISRC) established within the Environmental Restoration and Waste Management Department (ER WMD). The ISRC performs independent safety reviews for the ER WMD as required and specified by the governing documents mentioned above. This PMP defines the ISRC organization, work plan, and scope of work. The PMP is organized consistent with the requirements of DOE Order 4700.1, Project Management System. For the purpose of readability, this document shall use the term program'' to include not only the chartered activities of the ISRC, but also the related activities conducted by the chairman and staff. This PMP is subordinate to the ER WMD Implementing Program Management Plan, EGG-WM-10220.

  7. Environmental restoration and waste management department independent safety review committee program management plan

    SciTech Connect

    Not Available

    1992-10-01

    This Program Management Plan (PMP) describes and governs the Independent Safety Review Committee (ISRC) established within the Environmental Restoration and Waste Management Department (ER&WMD). The ISRC performs independent safety reviews for the ER&WMD as required and specified by the governing documents mentioned above. This PMP defines the ISRC organization, work plan, and scope of work. The PMP is organized consistent with the requirements of DOE Order 4700.1, Project Management System. For the purpose of readability, this document shall use the term ``program`` to include not only the chartered activities of the ISRC, but also the related activities conducted by the chairman and staff. This PMP is subordinate to the ER&WMD Implementing Program Management Plan, EGG-WM-10220.

  8. Developments in Aging: 1989. Volume 1. A Report of the Special Committee on Aging, United States Senate, Pursuant to S. RES. 66, SEC. 19, February 28, 1989, Resolution Authorizing a Study of the Problems of the Aged and Aging. 101st Congress, 2d Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document contains the 1989 annual report of the Senate Special Committee on Aging. It describes actions during 1989 by the Congress, the federal administration, and the U.S. Senate Special Committee on Aging, which are significant to America's older citizens. It also summarizes and analyzes the federal policies and programs that are of the…

  9. Developments in Aging: 1989. Volume 2--Appendixes. A Report of the Special Committee on Aging, United States Senate, Pursuant to S. RES. 66, SEC. 19, February 28, 1989, Resolution Authorizing a Study of the Problems of the Aged and Aging. 101st Congress, 2d Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document contains the appendices to the 1989 annual report of the Senate Special Committee on Aging which: (1) describes actions during 1989 by the Congress, the federal administration, and the U.S. Senate Special Committee on Aging, that are significant to America's older citizens; and (2) summarizes and analyzes the federal policies and…

  10. Olfaction and Aging: A Mini-Review.

    PubMed

    Attems, Johannes; Walker, Lauren; Jellinger, Kurt A

    2015-01-01

    Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those >80 years of age. Smell dysfunction significantly influences physical well-being, quality of life, nutritional status as well as everyday safety and is associated with increased mortality. Multiple factors contribute to age-related olfactory sensory loss, including nasal engorgement, cumulative damage of the olfactory epithelium from environmental insults, a reduction in mucosal metabolizing enzymes, sensory loss of receptor cells to odorants, and changes in neurotransmitter and neuromodulator systems. In addition, structural and functional abnormalities of the olfactory epithelium, olfactory bulb, central olfactory cortex, and basic olfactory circuitry, which are related to the neuronal expression of aberrant proteins in these areas, may result in olfactory sensory impairment in aging and neurodegenerative diseases. Impaired odour identification is associated with a decrease in cognitive abilities and memory decline. A reduction in the sense of smell is considered to potentially represent an early and important warning of neurodegenerative disorders, particularly of Parkinson's disease and Alzheimer's disease, and, in mild cognitive impairment, olfactory impairment may herald progression to dementia. Further investigations of the potential role of olfactory dysfunction in the early diagnosis and treatment of neurodegenerative diseases are warranted. PMID:25968962

  11. Olfaction and Aging: A Mini-Review.

    PubMed

    Attems, Johannes; Walker, Lauren; Jellinger, Kurt A

    2015-01-01

    Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those >80 years of age. Smell dysfunction significantly influences physical well-being, quality of life, nutritional status as well as everyday safety and is associated with increased mortality. Multiple factors contribute to age-related olfactory sensory loss, including nasal engorgement, cumulative damage of the olfactory epithelium from environmental insults, a reduction in mucosal metabolizing enzymes, sensory loss of receptor cells to odorants, and changes in neurotransmitter and neuromodulator systems. In addition, structural and functional abnormalities of the olfactory epithelium, olfactory bulb, central olfactory cortex, and basic olfactory circuitry, which are related to the neuronal expression of aberrant proteins in these areas, may result in olfactory sensory impairment in aging and neurodegenerative diseases. Impaired odour identification is associated with a decrease in cognitive abilities and memory decline. A reduction in the sense of smell is considered to potentially represent an early and important warning of neurodegenerative disorders, particularly of Parkinson's disease and Alzheimer's disease, and, in mild cognitive impairment, olfactory impairment may herald progression to dementia. Further investigations of the potential role of olfactory dysfunction in the early diagnosis and treatment of neurodegenerative diseases are warranted.

  12. [White House Conference on Aging, 1981. Abstracts of the Technical Committee Reports, Mini White House Conference Reports, and State White House Conference Reports.

    ERIC Educational Resources Information Center

    Cowell, Daniel D.

    This collection of abstracts, designed to assist White House Conference on Aging delegates involved with research on aging, presents information from 16 Technical Committee Reports which focus on implications of an age-integrated society, employment, support systems, health issues and services, the family, long-term care, older Americans as a…

  13. [White House Conference on Aging, 1981. Health Services. Report and Executive Summary of the Technical Committee.

    ERIC Educational Resources Information Center

    Beck, John; And Others

    The first section of this Technical Committee Report provides a brief summary of the major health problems of the elderly. Problems are categorized under the general headings of health maintenance, chronic illness, mental illness, multiple impairments, demographic characteristics, manpower (geriatric medicine, nursing, and other health…

  14. 78 FR 27977 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review... Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS)...

  15. [Review of WHO Expert Committee on Leprosy 8th report, --comparison to 7th report].

    PubMed

    Kitajima, Shinichi; En, Junichiro; Kitajima, Shiori; Barua, Sumana; Goto, Masamichi

    2014-03-01

    In 2012 the WHO Expert Committee on Leprosy published its 8th report, 14 years after the publication of its 7th report in 1998. This report, the first since the leprosy reduction goal was met in 2000, highlights key points such as improvements in the quality of various services available to patients and the efforts of individuals and societies, in addition to medical progress in diagnosis and treatment. This review will mainly describe the changes made since the 7th report. Some of the main modifications are the deletion of single lesion paucibacillary type, elongated treatment of patients with high bacterial indices, the introduction of promising new drugs, and a shift from reducing the statistical number of patients to a new target for disability prevention.

  16. UNOCAL Parachute Creek Shale Oil Project. Monitoring review committee meeting report. Annual meeting, 1987-1988

    SciTech Connect

    Not Available

    1988-05-25

    The Energy Security Act of 1980 established a program to provide financial assistance to private industry in the construction and operation of commercial-scale synthetic fuels plants. The Parachute Creek Shale Oil Program is one of four projects awarded financial assistance. The support agreement included development of an Environmental Monitoring Plan incorporating existing compliance monitoring and twenty-two supplemental monitoring points for water, air, solid waste, worker health and safety, and socio-economic impacts during the period 1986-1993. A Monitoring Review Committee (MRC) comprised of representatives from the Project, U.S. Department of Treasury, U.S. Department of Energy, U.S. Environmental Protection Agency, and the state convene each year to discuss monitoring information and trends in environmental and health surveillance. This report documents the first annual MRC meeting, held at the Project.

  17. Parachute Creek Shale Oil Project Monitoring Review Committee meeting report, August 9, 1990

    SciTech Connect

    Not Available

    1990-01-01

    The Energy Security Act of 1980 established a program to provide financial assistance to private industry in the construction and operation of commercial-scale synthetic fuels plants. The Parachute Creek Shale Oil Program is one of the four projects awarded financial assistance. The support agreement included development of an Environmental Monitoring Plan, incorporating existing compliance monitoring and supplemental monitoring on water, air, solid waste, worker health and safety, and socioeconomic impacts during the period 1986-1993. Phase I of the project is to produce 10,000 barrels per day of syncrude from oil shale, using the Unishale B process. The third annual meeting of the Monitoring Review Committee for the project included discussions of air, water and biological monitoring programs; spent shale pile inspecting; industrial hygiene monitoring; and medical assessments. Results of sampling 18 supplemental locations found no areas of significant environmental concern.

  18. 77 FR 5259 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... Scientific Review Special Emphasis Panel; Small Business: Drug Discovery for Aging, Neuropsychiatric and... Committee: Center for Scientific Review Special Emphasis Panel; Small Business: Non-HIV...

  19. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  20. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  1. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  2. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  3. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  4. Age, interpersonal attraction, and social interaction. A review and assessment.

    PubMed

    Webb, L; Delaney, J J; Young, L R

    1989-03-01

    This essay reviews over 40 extant research reports on attraction and aging. The review indicated that (a) perceived agreement in attitude tends to neutralize young adults' general perception of older adults as unattractive, (b) elders prefer to associate with middle-aged and older adults more than they desire to associate with younger adults, regardless of the relative physical attraction of the target individuals, and (c) elders' marital satisfaction appears to be related to perceived physical attractiveness of the husband, not the wife. The authors provide critique and analysis of the research methods employed in the reviewed studies. Avenues for further research are identified.

  5. Research ethics review practices: experiences of the Armauer Hansen Research Institute/All Africa Leprosy and Tuberculosis Rehabilitation and Training Center Ethics Review Committee, Ethiopia.

    PubMed

    Wassie, Liya; Woldeamanuel, Yimtubezinash; Gebre-Mariam, Senkenesh; Feleke, Yeweyenhareg; Temam, Fuad; Hailu, Abebe; Abay, Hiwot; Zerihun, Zeyin; Bussa, Solomon; Aberra, Lensa; Tarekegne, Geremew; Gebre-Yohannes, Asfawessen; Aseffa, Abraham

    2015-01-01

    The need for ethics review committees (ERCs) is imperative in the conduct of research to ensure the protection of the rights, safety and well-being of research participants. However, the capacities of most ERCs in Africa are limited in terms of trained experts, competence, resources as well as standard operating procedures. The aim of this report is to share experiences of one of the local institutional ERCs, the Armauer Hansen Research Institute (AHRI)/All Africa Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT) Ethics Review Committee (AAERC), to other ERCs found in academic and research institutions in the Country. In this report, we used an empirical approach to review archived documents of the AAERC Secretariat to assess the Committee's strengths and weaknesses. The experiences of the AAERC in terms of its composition, routine work activities, learning practices and pitfalls that require general attention are summarized. In spite of this summary, the Committee strongly acknowledges the functions and roles of other ERCs in the Country. In addition, an independent assessment of the Committee's activity in general is warranted to evaluate its performance and further assess the level of awareness or oversights among researchers about the roles of ERCs. PMID:25816497

  6. 76 FR 57064 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Clinical Aging Review Committee. Date: October... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact...

  7. 76 FR 3148 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Biological Aging Review Committee. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  8. 78 FR 52552 - National Institute on Aging Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group, Neuroscience of Aging Review Committee. Date..., johnsonj9@nia.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging...

  9. MHD Technology Transfer, Integration and Review Committee. Seventh semi-annual status report, April 1991--September 1991

    SciTech Connect

    Not Available

    1993-02-01

    This seventh semi-annual status report of the MHD Technology Transfer, Integration and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1991 through September 1991. It includes a summary and minutes of the General Committee meeting, progress summaries of ongoing POC contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months. The meeting included test plan with Western coal, seed regeneration economics, power management for the integrated topping cycle and status of the Clean Coal Technology Proposal activities. Appendices cover CDIF operations HRSR development, CFFF operations etc.

  10. Conversion of the DOD`s Technical Review Committees into Restoration Advisory Boards

    SciTech Connect

    Davidson, M.C.; Peters, J.E.

    1995-12-31

    The Department of the Navy designed a proactive community relations approach to accompany its environmental investigations, the Installation Restoration (IR) Program. The IR Program process mirrors that of the comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The goal of the IR Program is to identify, investigate, and if necessary, to clean up sites to reduce or eliminate threats to human health and the environment. The Environmental Protection Agency (EPA) is the lead agency at private facilities and the Navy is the lead agency at naval installations requiring study. While CERCLA mandates that sites listed on the National Priority List (NPL) fulfill community relations requirements, the Navy guidance states that all installations in the IR Program where a Remedial Investigation is conducted engage in proactive community relations, including non-NPL facilities. A primary part of the community involvement included forming Technical Review Committees (TRCs). TRCs were established to provide technical review of and public involvement in the IR Program. The Navy discovered that the technical nature of the TRCs excluded most of the public, and realized that increased community participation in the IR Program would benefit both the community and the Navy. Thus, the formation of Restoration Advisory Boards (RABs) was mandated in 1994. The additional community participation has enriched the entire community relations program. The partnering between the Navy, the community, the local, state, and federal environmental agencies has benefited the IR Program process.

  11. [AGING AND OSTEOARTHRITIS. CHRONIC NONSPECIFIC INFLAMMATION AS A LINK BETWEEN AGING AND OSTEOARTHRITIS (REVIEW)].

    PubMed

    Mendel, O I; Luchihina, L V; Mendel, W

    2015-01-01

    This article presents review on the processes underlying aging and the most common age-associated diseases. Special attention is given to the role of chronic nonspecific inflammation. Based on the literature data it was demonstrated that aging and osteoarthritis have the same basic molecular and cellular mechanisms, among which general are cascades intracellular transcription chronic nonspecific inflammation and metabolic disturbances plays an important role. It is concluded that the process of normal aging is not a disease, but makes the human body, and particularly the musculoskeletal system, susceptible to age-associated changes. Number of changes in the human body that accompany the aging process, and play a role in the development and progression of OA, are potentially reversible, regardless of age (eg, chronic non-specific inflammation), and can be considered as a possible entry points for the effective prevention and complex therapy of OA in elderly people.

  12. Report of the Ad Hoc Committee to Review the Status of Women at The Ohio State University, Phases I and II.

    ERIC Educational Resources Information Center

    Schoen, Kathryn T.; And Others

    In the late summer of 1970, an Ad Hoc Committee at the Ohio State University was appointed (1) to review the status of all women at the University; and (2) to submit a report of the findings and recommendations. The Committee consisted of 3 undergraduate students, 1 graduate student, 2 administrative personnel, and 3 faculty members, one of whom…

  13. Retirement before Age 65. Trends, Costs, and National Issues. Report to the Chairman, Select Committee on Aging, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    Two issues were analyzed--the changing characteristics of early pension recipients and the costs of early retirement. The analyses covered men and women aged 50 and older and were based primarily on data from the Census Bureau's March 1984 Current Population Survey. Findings showed that the percentage of the population receiving employer-sponsored…

  14. 11 CFR 116.7 - Debt settlement plans filed by terminating committees; Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... as defined in 11 CFR 116.1(a) shall file at least one debt settlement plan with the Commission prior to filing its termination report under 11 CFR 102.3. The terminating committee shall file a debt... debt settlement plan. The terminating committee shall not file its termination report under 11 CFR...

  15. 11 CFR 116.7 - Debt settlement plans filed by terminating committees; Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... as defined in 11 CFR 116.1(a) shall file at least one debt settlement plan with the Commission prior to filing its termination report under 11 CFR 102.3. The terminating committee shall file a debt... forgiveness of the particular debt(s) owed to each of them. The terminating committee shall not make...

  16. Establishing institutional ethics committees: challenges and solutions - a review of the literature.

    PubMed

    Kuyare, Mukta S; Taur, Santosh R; Thatte, Urmila M

    2014-01-01

    This review of the literature was conducted to identify the challenges faced while establishing institutional ethics committees (IECs) as well as to suggest some solutions. The search of the literature was carried out with the help of the PubMed search engine, using “research ethics committees” (MeSH] and “India” (MeSH]) as the key words for articles published between 2004 and 2012. We found 31 articles related to the topic, and the most common challenge mentioned was inappropriate functioning of IECs (n=17), followed by inappropriate structure (n=14). The authors identified many challenges related to the lack of oversight by regulatory bodies (n=14) as well as issues pertaining to the ethical training of IEC members and investigators (n=13). It is evident from the multitude of papers on the issue that the challenges related to the constitution and functioning of IECs must be given the attention they deserve to ensure that research participants in India are better protected.

  17. Aging techniques for deep vein thrombosis: a systematic review.

    PubMed

    Dharmarajah, B; Sounderajah, V; Rowland, S P; Leen, E L S; Davies, A H

    2015-03-01

    Deep vein thrombosis is common with an incidence of 1 in 1000. Acute thrombus removal for extensive proximal deep vein thrombosis using catheter-directed techniques highlights the need for accurate assessment of thrombus age. This systematic review summarises experimental and clinical evidence of imaging techniques for aging deep vein thrombosis. Ultrasound elastography and magnetic resonance imaging were highlighted as the most studied imaging modalities. Elastography was shown to distinguish between acute and chronic clots, despite demonstrating difficulty in accurate aging of clots older than 10 days in rat models. Elastography is noted as a feasible adjunct to current first-line imaging for deep vein thrombosis using duplex ultrasonography. Combinations of magnetic resonance imaging techniques can identify acute, sub-acute and chronic thrombi using endogenous contrast agents and provide objective standardisation of the diagnostic process, with reduced onus upon operator dependency. Further validation is required of these novel imaging techniques prior to clinical implementation for deep vein thrombosis aging.

  18. Training Needs in Gerontology; Hearing before the Special Committee on Aging, United States Senate, Ninety-Fourth Congress, First Session. Part 3--Washington, D.C.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    Hearing before the Senate Special Committee on Aging was held to consider the need for funds to provide professional training in the field of gerontology as authorized under the Older Americans Act. Provision for special skills training was made under title IV of the Act but no funds were included for it in the 1975 and 1976 budgets. A statement…

  19. Dying with Dignity: Difficult Times, Difficult Choices. A Report Presented by the Chairman of the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This report from the Select Committee on Aging examines financial, medical, and social issues surrounding terminally ill patients with special emphasis on the elderly terminally ill. The first section discusses topics related to the medical treatment of the terminally ill. Two basic issues are important: the right to have medical treatment and the…

  20. Long-Term Care in America: The People's Call for Federal Action. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document presents prepared statements and testimony from the Congressional hearing on the federal government's role in providing long-term care for the elderly in America. Opening statements from the chairman and three members of the Select Committee on Aging focus on the financial burden of long-term care for America's elderly, the…

  1. Work after 65: Options for the 80's. Hearing before the Special Committee on Aging, United States Senate, Ninety-Sixth Congress, Second Session. Part 3--Orlando, Fla.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    The problem of senior citizens in Florida who need to work are chronicled in this third part of the Senate Special Committee on Aging, Work after 65 hearings, conducted in Orlando, Florida, in July, 1980. During the Florida hearing, representatives of various government programs for senior citizens, professors of education and economics and…

  2. Animals, science, and ethics -- Section IV. Ethical review and the animal care and use committee.

    PubMed

    Rowan, Andrew N

    1990-01-01

    Section IV takes a close practical look at Animal Care and Use Committees, their history, mandates, and the impediments they still experience in trying to promote animal welfare and an ethical scientific use of animals.

  3. 76 FR 61072 - Committees on Administration and Management, Collaborative Governance, Judicial Review, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... agency #0;statements of organization and functions are examples of documents #0;appearing in this section... materials; virtual committee meetings; and other improvements that might reduce the burdens imposed by...

  4. 76 FR 12315 - Committees on Collaborative Governance, Regulation, Rulemaking, Judicial Review, and Adjudication

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ..., March 25, 2011, from 9 a.m. to 12 noon. Designated Federal Officer: Emily F. Schleicher. Committee on.... Schleicher and Jonathan R. Siegel. Date: Monday, March 28, 2011, from 2 p.m. to 5 p.m. Designated...

  5. Pharmacotherapy in the ageing patient: The impact of age per se (A review).

    PubMed

    Singh, Shamsher; Bajorek, Beata

    2015-11-01

    A literature search was carried out to review the influence of 'ageing' on pharmacotherapeutic decision-making, specifically how 'age' is defined and considered in the utilisation of medication. Embase, Medline, International Pharmaceutical Abstracts, and Google scholar were canvassed in a three-tiered search according to pre-established inclusion criteria. In tier 1, a total of 22 studies were identified highlighting the underutilisation of medication in elderly patients, with a particular focus on warfarin. Four studies highlighted an age-bias in medication-prescribing for elderly patients, specifically in relation to medicines for rheumatoid arthritis, angina, and hypertension. Tier 2 identified diverse definitions for 'elderly', including biological age, chronological age, physiological age, as well as various descriptions of 'elderly' in clinical trials and guidelines. Finally, medication optimisation tools were identified through the third tier, emphasising the use of chronological age to describe the 'elderly'. Old age influences pharmacotherapeutic decision-making at various levels, however, what complicates the situation is the absence of a comprehensive definition of 'elderly'. Clinical recommendations need to be based more on objective factors known to affect medication effectiveness and safety.

  6. Smoking and Age-Related Macular Degeneration: Review and Update

    PubMed Central

    Velilla, Sara; García-Medina, José Javier; García-Layana, Alfredo; Pons-Vázquez, Sheila; Pinazo-Durán, M. Dolores; Gómez-Ulla, Francisco; Arévalo, J. Fernando; Díaz-Llopis, Manuel; Gallego-Pinazo, Roberto

    2013-01-01

    Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evaluating the association between smoking and AMD, the mechanisms through which smoking induces damage to the chorioretinal tissues, and the relevance of advising patients to quit smoking for their visual health. PMID:24368940

  7. Computationally Modeling Lipid Metabolism and Aging: A Mini-review

    PubMed Central

    Mc Auley, Mark T.; Mooney, Kathleen M.

    2014-01-01

    One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system. PMID:25750699

  8. The influences of age on olfaction: a review

    PubMed Central

    Doty, Richard L.; Kamath, Vidyulata

    2014-01-01

    Decreased olfactory function is very common in the older population, being present in over half of those between the ages of 65 and 80 years and in over three quarters of those over the age of 80 years. Such dysfunction significantly influences physical well-being and quality of life, nutrition, the enjoyment of food, as well as everyday safety. Indeed a disproportionate number of the elderly die in accident gas poisonings each year. As described in this review, multiple factors contribute to such age-related loss, including altered nasal engorgement, increased propensity for nasal disease, cumulative damage to the olfactory epithelium from viral and other environmental insults, decrements in mucosal metabolizing enzymes, ossification of cribriform plate foramina, loss of selectivity of receptor cells to odorants, changes in neurotransmitter and neuromodulator systems, and neuronal expression of aberrant proteins associated with neurodegenerative disease. It is now well established that decreased smell loss can be an early sign of such neurodegenerative diseases as Alzheimer's disease and sporadic Parkinson's disease. In this review we provide an overview of the anatomy and physiology of the aging olfactory system, how this system is clinically evaluated, and the multiple pathophysiological factors that are associated with its dysfunction. PMID:24570664

  9. The influences of age on olfaction: a review.

    PubMed

    Doty, Richard L; Kamath, Vidyulata

    2014-01-01

    Decreased olfactory function is very common in the older population, being present in over half of those between the ages of 65 and 80 years and in over three quarters of those over the age of 80 years. Such dysfunction significantly influences physical well-being and quality of life, nutrition, the enjoyment of food, as well as everyday safety. Indeed a disproportionate number of the elderly die in accident gas poisonings each year. As described in this review, multiple factors contribute to such age-related loss, including altered nasal engorgement, increased propensity for nasal disease, cumulative damage to the olfactory epithelium from viral and other environmental insults, decrements in mucosal metabolizing enzymes, ossification of cribriform plate foramina, loss of selectivity of receptor cells to odorants, changes in neurotransmitter and neuromodulator systems, and neuronal expression of aberrant proteins associated with neurodegenerative disease. It is now well established that decreased smell loss can be an early sign of such neurodegenerative diseases as Alzheimer's disease and sporadic Parkinson's disease. In this review we provide an overview of the anatomy and physiology of the aging olfactory system, how this system is clinically evaluated, and the multiple pathophysiological factors that are associated with its dysfunction.

  10. Progress in Modeling Pu Properties and Aging - ESC Review, March 19-23, 2001

    SciTech Connect

    Wolfer, W G; Caturla, M; Kubota, A; Quong, A; Sadigh, B; Sterne, P; Surh, M; Schaldach, C; Wirth, B

    2001-03-29

    An important component of the Pu aging programs both here at LLNL and at LANL is the development of models for the aging processes. These models will, in the foreseeable future, be validated with more and more data from different experiments, and eventually enable us to predict the lifetime of pits. The processes of aging from within the material are mainly caused by the radioactive decay of Pu, and this produces three drivers for changes in properties: (1) Radiation damage in the form of displacements, of defects, of dislocations, and voids. (2) Helium will aggregate in the form of bubbles and cavities. (3) Uranium, Americium, and Neptunium will change the chemical composition and perhaps the phase stability. All the three drivers act synergistically, no doubt. But it is useful to approach the complexity of Pu aging with the strategy of ''first divide, conquer, and then unify''. In this spirit, we have divided the program into three major task areas with individual subtasks to be conquered by various researchers. The subtasks and staffing has changed somewhat from last year, and this is indicated on the viewgraph by underlines. Undoubtedly, it will change in the future, but the objectives of the major tasks and of the entire project will not change until the mission as stated at the beginning will have been accomplished. As you see from the third task, there is a strong emphasis on providing theoretical and computational support for critical, fundamental experiments. Before reviewing the progress made last year for the various tasks, let me briefly state what the physical properties are that we monitor for signs of aging. Prominent is the change in density and microstructure, and its effects on strength and EOS. You will hear little if anything at all about the latter two properties, but work is in progress on these issues, and the review committee will hear about it at the next review. For this review, I want to concentrate on dimensional changes and the

  11. Cutaneous wound healing in aging small mammals: a systematic review.

    PubMed

    Kim, Dong Joo; Mustoe, Thomas; Clark, Richard A F

    2015-01-01

    As the elderly population grows, so do the clinical and socioeconomic burdens of nonhealing cutaneous wounds, the majority of which are seen among persons over 60 years of age. Human studies on how aging effects wound healing will always be the gold standard, but studies have ethical and practical hurdles. Choosing an animal model is dictated by costs and animal lifespan that preclude large animal use. Here, we review the current literature on how aging effects cutaneous wound healing in small animal models and, when possible, compare healing across studies. Using a literature search of MEDLINE/PubMed databases, studies were limited to those that utilized full-thickness wounds and compared the wound-healing parameters of wound closure, reepithelialization, granulation tissue fill, and tensile strength between young and aged cohorts. Overall, wound closure, reepithelialization, and granulation tissue fill were delayed or decreased with aging across different strains of mice and rats. Aging in mice was associated with lower tensile strength early in the wound healing process, but greater tensile strength later in the wound healing process. Similarly, aging in rats was associated with lower tensile strength early in the wound healing process, but no significant tensile strength difference between young and old rats later in healing wounds. From studies in New Zealand White rabbits, we found that reepithelialization and granulation tissue fill were delayed or decreased overall with aging. While similarities and differences in key wound healing parameters were noted between different strains and species, the comparability across the studies was highly questionable, highlighted by wide variability in experimental design and reporting. In future studies, standardized experimental design and reporting would help to establish comparable study groups, and advance the overall knowledge base, facilitating the translatability of animal data to the human clinical condition.

  12. Leprosy among children under 15 years of age: literature review*

    PubMed Central

    de Oliveira, Marcela Bahia Barretto; Diniz, Lucia Martins

    2016-01-01

    Leprosy is a chronic infectious disease caused by Mycobacterium leprae, representing a public health issue in some countries. Though more prevalent in adults, the detection of new cases in children under 15 years of age reveals an active circulation of bacillus, continued transmission and lack of disease control by the health system, as well as aiding in the monitoring of the endemic. Among patients under 15 years of age, the most affected age group is children between 10 and 14 years of age, although cases of patients of younger than 1 year of age have also been reported. Household contacts are the primary source of infection, given that caretakers, such as babysitters and others, must be considered in this scenario. Paucibacillary forms of the disease prevailed, especially borderline-tuberculoid leprosy, with a single lesion in exposed areas of the body representing the main clinical manifestation. Reactional states: Lepra reactions are rare, although some authors have reported high frequencies of this phenomenon, the most frequent of which is Type 1 Lepra Reaction. Peripheral nerve involvement has been described at alarming rates in some studies, which increases the chance of deformities, a serious problem, especially if one considers the age of these patients. The protective effect of BCG vaccination was found in some studies, but no consensus has been reached among different authors. Children must receive the same multidrug therapy regimen and the doses should, ideally, be calculated based on the child´s weight. Adverse reactions to this therapy are rare within this age group. This article aims to review epidemiological, clinical, and therapeutic aspects of leprosy in patients under 15 years of age. PMID:27192519

  13. Leprosy among children under 15 years of age: literature review.

    PubMed

    Oliveira, Marcela Bahia Barretto de; Diniz, Lucia Martins

    2016-04-01

    Leprosy is a chronic infectious disease caused by Mycobacterium leprae, representing a public health issue in some countries. Though more prevalent in adults, the detection of new cases in children under 15 years of age reveals an active circulation of bacillus, continued transmission and lack of disease control by the health system, as well as aiding in the monitoring of the endemic. Among patients under 15 years of age, the most affected age group is children between 10 and 14 years of age, although cases of patients of younger than 1 year of age have also been reported. Household contacts are the primary source of infection, given that caretakers, such as babysitters and others, must be considered in this scenario. Paucibacillary forms of the disease prevailed, especially borderline-tuberculoid leprosy, with a single lesion in exposed areas of the body representing the main clinical manifestation. Reactional states: Lepra reactions are rare, although some authors have reported high frequencies of this phenomenon, the most frequent of which is Type 1 Lepra Reaction. Peripheral nerve involvement has been described at alarming rates in some studies, which increases the chance of deformities, a serious problem, especially if one considers the age of these patients. The protective effect of BCG vaccination was found in some studies, but no consensus has been reached among different authors. Children must receive the same multidrug therapy regimen and the doses should, ideally, be calculated based on the child´s weight. Adverse reactions to this therapy are rare within this age group. This article aims to review epidemiological, clinical, and therapeutic aspects of leprosy in patients under 15 years of age. PMID:27192519

  14. The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members

    PubMed Central

    Hunt, Matthew; Tansey, Catherine M.

    2016-01-01

    Background Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversight of disaster research also poses challenges for research ethics committees (RECs), in part due to the rapid turnaround needed to initiate research after a disaster. Currently, there is limited knowledge available about how RECs respond to and appraise disaster research. To address this knowledge gap, we investigated the experiences of REC members who had reviewed disaster research conducted in low- or middle-income countries. Methods We used interpretive description methodology and conducted in-depth interviews with 15 respondents. Respondents were chairs, members, advisors, or coordinators from 13 RECs, including RECs affiliated with universities, governments, international organizations, a for-profit REC, and an ad hoc committee established during a disaster. Interviews were analyzed inductively using constant comparative techniques. Results Through this process, three elements were identified as characterizing effective and high-quality review: timeliness, responsiveness and rigorousness. To ensure timeliness, many RECs rely on adaptations of review procedures for urgent protocols. Respondents emphasized that responsive review requires awareness of and sensitivity to the particularities of disaster settings and disaster research. Rigorous review was linked with providing careful assessment of ethical considerations related to the research, as well as ensuring independence of the review process. Conclusion Both the frequency of disasters and the conduct of disaster research are on the rise. Ensuring effective and high quality review of disaster research is crucial, yet challenges, including time pressures for urgent protocols, exist for achieving this goal. Adapting standard REC procedures may be necessary. However

  15. Aging and the neuroeconomics of decision making: A review.

    PubMed

    Brown, Stephen B R E; Ridderinkhof, K Richard

    2009-12-01

    Neuroeconomics refers to a combination of paradigms derived from neuroscience, psychology, and economics for the study of decision making and is an area that has received considerable scientific attention in the recent literature. Using realistic laboratory tasks, researchers seek to study the neurocognitive processes underlying economic decision making and outcome-based decision learning, as well as individual differences in these processes and the social and affective factors that modulate them. To this point, one question has remained largely unanswered: What happens to decision-making processes and their neural substrates during aging? After all, aging is associated with neurocognitive change, which may affect outcome-based decision making. In our study, we use the subjective expected utility model-a well-established decision-making model in economics-as a descriptive framework. After a short survey of the brain areas and neurotransmitter systems associated with outcome-based decision making-and of the effects of aging thereon-we review a number of decision-making studies. Their general data pattern indicates that the decision-making process is changed by age: The elderly perform less efficiently than younger participants, as demonstrated, for instance, by the smaller total rewards that the elderly acquire in lab tasks. These findings are accounted for in terms of age-related deficiencies in the probability and value parameters of the subjective expected utility model. Finally, we discuss some implications and suggestions for future research.

  16. Can Aging in Place Be Cost Effective? A Systematic Review

    PubMed Central

    Graybill, Erin M.; McMeekin, Peter; Wildman, John

    2014-01-01

    Purpose of the Study To systematically review cost, cost-minimization and cost-effectiveness studies for assisted living technologies (ALTs) that specifically enable older people to ‘age in place’ and highlight what further research is needed to inform decisions regarding aging in place. Design People aged 65+ and their live-in carers (where applicable), using an ALT to age in place at home opposed to a community-dwelling arrangement. Methods Studies were identified using a predefined search strategy on two key economic and cost evaluation databases NHS EED, HEED. Studies were assessed using methods recommended by the Campbell and Cochrane Economic Methods Group and presented in a narrative synthesis style. Results Eight eligible studies were identified from North America spread over a diverse geographical range. The majority of studies reported the ALT intervention group as having lower resource use costs than the control group; though the low methodological quality and heterogeneity of the individual costs and outcomes reported across studies must be considered. Implications The studies suggest that in some cases ALTs may reduce costs, though little data were identified and what there were was of poor quality. Methods to capture quality of life gains were not used, therefore potential effects on health and wellbeing may be missed. Further research is required using newer developments such as the capabilities approach. High quality studies assessing the cost-effectiveness of ALTs for ageing in place are required before robust conclusion on their use can be drawn. PMID:25058505

  17. Age Discrimination and the FAA Age 60 Rule. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document presents witness testimonies and related materials from a Congressional hearing called to examine the mandatory retirement age of 60 for airline pilots. In opening remarks, Congressmen Roybal and Pepper question this ruling, citing productivity of older workers and the lack of data to support any specific age for mandatory…

  18. Relaxation and physical aging in network glasses: a review

    NASA Astrophysics Data System (ADS)

    Micoulaut, Matthieu

    2016-06-01

    Recent progress in the description of glassy relaxation and aging are reviewed for the wide class of network-forming materials such as GeO2, Ge x Se1-x , silicates (SiO2-Na2O) or borates (B2O3-Li2O), all of which have an important usefulness in domestic, geological or optoelectronic applications. A brief introduction of the glass transition phenomenology is given, together with the salient features that are revealed both from theory and experiments. Standard experimental methods used for the characterization of the slowing down of the dynamics are reviewed. We then discuss the important role played by aspects of network topology and rigidity for the understanding of the relaxation of the glass transition, while also permitting analytical predictions of glass properties from simple and insightful models based on the network structure. We also emphasize the great utility of computer simulations which probe the dynamics at the molecular level, and permit the calculation of various structure-related functions in connection with glassy relaxation and the physics of aging which reveal the non-equilibrium nature of glasses. We discuss the notion of spatial variations of structure which leads to the concept of ‘dynamic heterogeneities’, and recent results in relation to this important topic for network glasses are also reviewed.

  19. Relaxation and physical aging in network glasses: a review

    NASA Astrophysics Data System (ADS)

    Micoulaut, Matthieu

    2016-06-01

    Recent progress in the description of glassy relaxation and aging are reviewed for the wide class of network-forming materials such as GeO2, Ge x Se1‑x , silicates (SiO2–Na2O) or borates (B2O3–Li2O), all of which have an important usefulness in domestic, geological or optoelectronic applications. A brief introduction of the glass transition phenomenology is given, together with the salient features that are revealed both from theory and experiments. Standard experimental methods used for the characterization of the slowing down of the dynamics are reviewed. We then discuss the important role played by aspects of network topology and rigidity for the understanding of the relaxation of the glass transition, while also permitting analytical predictions of glass properties from simple and insightful models based on the network structure. We also emphasize the great utility of computer simulations which probe the dynamics at the molecular level, and permit the calculation of various structure-related functions in connection with glassy relaxation and the physics of aging which reveal the non-equilibrium nature of glasses. We discuss the notion of spatial variations of structure which leads to the concept of ‘dynamic heterogeneities’, and recent results in relation to this important topic for network glasses are also reviewed.

  20. 12 CFR 620.31 - Compensation committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... reviewing the compensation policies and plans for senior officers and employees. Each compensation committee... provide monetary and nonmonetary resources to enable its compensation committee to function....

  1. Advisory Committee on Immunization Practices recommended immunization schedule for adults aged 19 years or older - United States, 2014.

    PubMed

    Bridges, Carolyn B; Coyne-Beasley, Tamera

    2014-02-01

    Vaccines are recommended for adults on the basis of their age, prior vaccinations, health conditions, lifestyle, occupation, and travel. Reasons for current low levels of vaccination coverage for adult vaccines are multifactorial and include limited awareness among the public about vaccines for adults and gaps in incorporation of regular assessments of vaccine needs and vaccination into routine medical care. Updated standards for immunization of adults were approved by the National Vaccine Advisory Committee (NVAC) in September 2013. These standards acknowledge the current low levels of vaccination coverage among adults and the role that all health-care providers, including those who do not offer all recommended adult vaccines in their practices, have in ensuring that their patients are up-to-date on recommended vaccines. NVAC recommends that providers assess vaccination needs for their patients at each visit, recommend needed vaccines, and then, ideally, offer the vaccine or, if the provider does not stock the needed vaccines, refer the patient to a provider who does vaccinate. Vaccinating providers should also ensure that patients and their referring health-care providers have documentation of the vaccination.

  2. Red meat consumption and healthy ageing: A review.

    PubMed

    Kouvari, Matina; Tyrovolas, Stefanos; Panagiotakos, Demosthenes B

    2016-02-01

    According to World Health Organization older individuals is the fastest growing age-group around the globe, thanks to the tremendous improvements in medical and pharmaceutical therapies, as well as in quality of life. Unfortunately, this raise in life span is accompanied by significant increase in disease burden, and consequent economical costs. Lifestyle modifications and effective prevention strategies have shown considerable benefits as regards the development of age-oriented chronic diseases. Among lifestyle factors, nutrition is a key component for achieving good health. Nevertheless, this parameter has insufficiently been investigated in older people. This is a rather important scientific gap, considering the westernization of nutritional habits observed the last few decades, with high red meat consumption and its processed products being an indispensable part. Moreover, its adverse impact in cardiovascular disease and cancer has been extensively investigated, while in recent literature, interest has been remarkably oriented towards its subtypes (i.e., fresh and processed); however, outcomes as regards the older population are controversial with a variety of them proposing moderation of red meat mainly the processed type, whilst others recognizing fresh red meat, especially the lean type, an important source of high quality protein so as to manage muscle tissue loss, a common implication of advanced-age discount. The aim of the present review was to present an overview of studies which have investigated the association between red meat and its subtypes, with chronic diseases, in middle and advanced age individuals. PMID:26642896

  3. Optimising nutrition in residential aged care: A narrative review.

    PubMed

    Agarwal, Ekta; Marshall, Skye; Miller, Michelle; Isenring, Elisabeth

    2016-10-01

    In developed countries the prevalence of protein-energy malnutrition increases with age and multi-morbidities increase nutritional risk in aged care residents in particular. This paper presents a narrative review of the current literature on the identification, prevalence, associated risk factors, consequences, and management of malnutrition in the residential aged care (RAC) setting. We performed searches of English-language publications on Medline, PubMed, Ovid and the Cochrane Library from January 1, 1990 to November 25, 2015. We found that, on average, half of all residents in aged care are malnourished as a result of factors affecting appetite, dietary intake and nutrient absorption. Malnutrition is associated with a multitude of adverse outcomes, including increased risk of infections, falls, pressure ulcers and hospital admissions, all of which can lead to increased health care costs and poorer quality of life. A number of food and nutrition strategies have demonstrated positive nutritional and clinical outcomes in the RAC setting. These strategies extend beyond simply enhancing the nutritional value of foods and hence necessitate the involvement of a range of committed stakeholders. Implementing a nutritional protocol in RAC facilities that comprises routine nutrition screening, assessment, appropriate nutrition intervention, including attention to food service systems, and monitoring by a multidisciplinary team can help prevent decline in residents' nutritional status. Food and nutritional issues should be identified early and managed on admission and regularly in the RAC setting. PMID:27621242

  4. Red meat consumption and healthy ageing: A review.

    PubMed

    Kouvari, Matina; Tyrovolas, Stefanos; Panagiotakos, Demosthenes B

    2016-02-01

    According to World Health Organization older individuals is the fastest growing age-group around the globe, thanks to the tremendous improvements in medical and pharmaceutical therapies, as well as in quality of life. Unfortunately, this raise in life span is accompanied by significant increase in disease burden, and consequent economical costs. Lifestyle modifications and effective prevention strategies have shown considerable benefits as regards the development of age-oriented chronic diseases. Among lifestyle factors, nutrition is a key component for achieving good health. Nevertheless, this parameter has insufficiently been investigated in older people. This is a rather important scientific gap, considering the westernization of nutritional habits observed the last few decades, with high red meat consumption and its processed products being an indispensable part. Moreover, its adverse impact in cardiovascular disease and cancer has been extensively investigated, while in recent literature, interest has been remarkably oriented towards its subtypes (i.e., fresh and processed); however, outcomes as regards the older population are controversial with a variety of them proposing moderation of red meat mainly the processed type, whilst others recognizing fresh red meat, especially the lean type, an important source of high quality protein so as to manage muscle tissue loss, a common implication of advanced-age discount. The aim of the present review was to present an overview of studies which have investigated the association between red meat and its subtypes, with chronic diseases, in middle and advanced age individuals.

  5. Predicting low testosterone in aging men: a systematic review

    PubMed Central

    Millar, Adam C.; Lau, Adrian N.C.; Tomlinson, George; Kraguljac, Alan; Simel, David L.; Detsky, Allan S.; Lipscombe, Lorraine L.

    2016-01-01

    Background: Physicians diagnose and treat suspected hypogonadism in older men by extrapolating from the defined clinical entity of hypogonadism found in younger men. We conducted a systematic review to estimate the accuracy of clinical symptoms and signs for predicting low testosterone among aging men. Methods: We searched the MEDLINE and Embase databases (January 1966 to July 2014) for studies that compared clinical features with a measurement of serum testosterone in men. Three of the authors independently reviewed articles for inclusion, assessed quality and extracted data. Results: Among 6053 articles identified, 40 met the inclusion criteria. The prevalence of low testosterone ranged between 2% and 77%. Threshold testosterone levels used for reference standards also varied substantially. The summary likelihood ratio associated with decreased libido was 1.6 (95% confidence interval [CI] 1.3–1.9), and the likelihood ratio for absence of this finding was 0.72 (95% CI 0.58–0.85). The likelihood ratio associated with the presence of erectile dysfunction was 1.5 (95% CI 1.3–1.8) and with absence of erectile dysfunction was 0.83 (95% CI 0.76–0.91). Of the multiple-item instruments, the ANDROTEST showed both the most favourable positive likelihood ratio (range 1.9–2.2) and the most favourable negative likelihood ratio (range 0.37–0.49). Interpretation: We found weak correlation between signs, symptoms and testosterone levels, uncertainty about what threshold testosterone levels should be considered low for aging men and wide variation in estimated prevalence of the condition. It is therefore difficult to extrapolate the method of diagnosing pathologic hypogonadism in younger men to clinical decisions regarding age-related testosterone decline in aging men. PMID:27325129

  6. Employment Problems of Older Workers: A Review by the International Labor Organization Advisory Committee

    ERIC Educational Resources Information Center

    Feldman, Lloyd

    1975-01-01

    A subcommittee of the ILO Advisory Committee on Salaried Employees and Professional Workers, focusing attention in 1974 on problems and opportunities of employment and reemployment of older adults, discovered that U. S. policy compares favorably with that of other developed countries, urged studies of inflation's impact, and recommended flexible…

  7. 78 FR 52233 - Motor Carrier Safety Advisory Committee (MCSAC) and Medical Review Board (MRB): Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... motorcoach drivers, and the North American Fatigue Management Program. On the afternoon of September 10, the committees will receive briefings on Schedule II medications. On Wednesday, September 11, MCSAC's Compliance... information about Schedule II medications and their effect on CMV drivers' ability to operate safely....

  8. Use of a Committee Review Process to Improve the Quality of Course Examinations

    ERIC Educational Resources Information Center

    Wallach, P. M.; Crespo, L. M.; Holtzman, K. Z.; Galbraith, R. M.; Swanson, D. B.

    2006-01-01

    Purpose: In conjunction with curricular changes, a process to develop integrated examinations was implemented. Pre-established guidelines were provided favoring vignettes, clinically relevant material, and application of knowledge rather than simple recall. Questions were read aloud in a committee including all course directors, and a reviewer…

  9. ADAAG Review Federal Advisory Committee Recommendations for a New ADAAG. Final Report.

    ERIC Educational Resources Information Center

    Architectural and Transportation Barriers Compliance Board, Washington, DC.

    This report presents the final recommendations, in the form of a new set of guidelines, of a federal advisory committee concerning revisions to the Americans with Disabilities Act Accessibility Guidelines (ADAAG). The guidelines provide scoping and technical requirements for the design, construction, and alteration of sites, facilities, buildings,…

  10. 76 FR 31578 - Siskiyou Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... Forest Service Siskiyou Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Siskiou Resource Advisory Committee will meet in Smith River, California. The..., OR Resource Advisory committee for Josephine, Coos and Curry Counties; review and recommend...

  11. 76 FR 44963 - Committee Management; Renewals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Committee Management; Renewals The NSF management officials having responsibility for the Proposal Review... determination follows consultation with the Committee Management Secretariat, General Services Administration... (703) 292-7488. Dated: July 22, 2011. Susanne Bolton, Committee Management Officer. BILLING CODE...

  12. 78 FR 26054 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Committee: National Institute on Aging Initial Review Group; Clinical Aging Review Committee, NIA-C. Date.... Place: Courtyard Long Beach Downtown, 500 East First Street, Long Beach, CA 90802. Contact Person... Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, 301-496-9666 markowsa@nia.nih.gov ....

  13. Review on hygroscopic aging of cellulose fibres and their biocomposites.

    PubMed

    Mokhothu, Thabang H; John, Maya Jacob

    2015-10-20

    This review presents critical literature on effects of humidity and temperature on the properties of natural fibres and its composites. The drawback of moisture absorption on the mechanical properties of natural fibre and its composites is evaluated. Numerous researchers have been working to address the moisture absorption issue, with specific attention paid to the surface treatment of fibres and refining the fibre-matrix interface. Because of the natural fibre's positive commercial and environmental outcomes, as well as their desirable properties such as high specific strength, natural fibre reinforced composites are displaying a good potential to be used in various applications such as automotive, aerospace and packaging. This review addresses a comprehensive survey on hygroscopic factors (long term environmental aging) affecting natural fibres and their performance as reinforcement in polymer composites. The effects of cellulose surface chemistry and topography on hydrophobicity are addressed. Furthermore, the review also addresses the progress in the development of superhydrophobic materials based on cellulose material for better moisture resistance. In addition, recent investigations dealing with bio-based coatings prepared from renewable resources are also discussed.

  14. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 2. Evaluation of seismic designs: a review of seismic design requirements for Nuclear Power Plant Piping

    SciTech Connect

    Not Available

    1985-04-01

    This document reports the position and recommendations of the NRC Piping Review Committee, Task Group on Seismic Design. The Task Group considered overlapping conservation in the various steps of seismic design, the effects of using two levels of earthquake as a design criterion, and current industry practices. Issues such as damping values, spectra modification, multiple response spectra methods, nozzle and support design, design margins, inelastic piping response, and the use of snubbers are addressed. Effects of current regulatory requirements for piping design are evaluated, and recommendations for immediate licensing action, changes in existing requirements, and research programs are presented. Additional background information and suggestions given by consultants are also presented.

  15. Statistical Policy for an Aging America. Joint Hearing before the Subcommittee on Energy, Nuclear Proliferation, and Government Processes of the Committee on Governmental Affairs and the Subcommittee on Aging of the Committee on Labor and Human Resources. United States Senate, Ninety-Ninth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Governmental Affairs.

    Testimony on the need for building an information base on the changing demographics of an aging society in order to make intelligent policy decisions is presented in this Senate committee hearing. Opening statements by Senators Charles Grassley and John Glenn are provided. Jacob A. Brody, dean of the School of Public Health, University of Illinois…

  16. Biomedical Research Ethics Committees in sub-Saharan Africa: a collective review of their structure, functioning, and outcomes.

    PubMed

    Silaigwana, Blessing; Wassenaar, Douglas

    2015-04-01

    Research Ethics Committees (RECs) are mandated to protect human participants by conducting ethical reviews of biomedical research. To date, there is a dearth of information on the structure, functioning, and outcomes of RECs in Africa. This article reviews empirical studies investigating African RECs, with the aim of providing an overview of what is known and identifying gaps in our knowledge. We conducted a literature search of the EBSCO, PubMed, and Google Scholar electronic databases. Twenty-three empirical studies reporting on the structure, functions, and outcomes of African RECs were included in our analysis. The review yielded limited systematic data on RECs in Africa. Available empirical evidence suggests that challenges hampering the effective functioning of RECs included lack of membership diversity, scarcity of resources, insufficient training of members, inadequate capacity to review and monitor studies, and lack of national ethics guidelines and accreditation. Relatively little data on the review outcomes of African RECs were described. There is an ongoing need for concerted efforts from various stakeholders to support capacity development and enhancement of African RECs.

  17. 77 FR 24969 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review.... Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes of...

  18. 76 FR 6628 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review... Person: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institutes On Aging,...

  19. 76 FR 24901 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institute on Aging, National Institutes...

  20. 78 FR 55752 - National Institute On Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... HUMAN SERVICES National Institutes of Health National Institute On Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Rebecca J. Ferrell, Ph.D., Scientific Review Officer, National Institute on Aging, Gateway Building,...

  1. 77 FR 6129 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review...: Jeannette L. Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes...

  2. 75 FR 56119 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review...: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institutes on Aging, National Institutes...

  3. 77 FR 53207 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Jeannette L. Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes...

  4. Developments in Aging: 1976. Part 1. A Report of the Special Committee on Aging, United States Senate, Pursuant to S. Res. 373, March 1, 1976 Resolution Authorizing a Study of the Problems of the Aged and Aging Together with Minority Views. 95th Congress, 1st Session. Report No. 95-88.

    ERIC Educational Resources Information Center

    1977

    The first part of a report by the Special Committee on Aging of the United States Senate provides additional evidence about the need for far-ranging federal attention to the needs and aspirations of older Americans. A number of difficulties such as special transportation needs in rural areas, contradictions in policies and programs, and disaster…

  5. Review: Cerebral microvascular pathology in aging and neurodegeneration

    PubMed Central

    Brown, William R.; Thore, Clara R.

    2010-01-01

    This review of age-related brain microvascular pathologies focuses on topics studied by this laboratory, including anatomy of the blood supply, tortuous vessels, venous collagenosis, capillary remnants, vascular density, and microembolic brain injury. Our studies feature thick sections, large blocks embedded in celloidin, and vascular staining by alkaline phosphatase (AP). This permits study of the vascular network in three dimensions, and the differentiation of afferent from efferent vessels. Current evidence suggests that there is decreased vascular density in aging, Alzheimer’s disease (AD), and leukoaraiosis (LA), and cerebrovascular dysfunction precedes and accompanies cognitive dysfunction and neurodegeneration. A decline in cerebrovascular angiogenesis may inhibit recovery from hypoxia-induced capillary loss. Cerebral blood flow (CBF) is inhibited by tortuous arterioles and deposition of excessive collagen in veins and venules. Misery perfusion due to capillary loss appears to occur before cell loss in LA, and CBF is also reduced in the normal-appearing white matter. Hypoperfusion occurs early in AD, inducing white matter lesions and correlating with dementia. In vascular dementia, cholinergic reductions are correlated with cognitive impairment, and cholinesterase inhibitors have some benefit. Most lipid microemboli from cardiac surgery pass through the brain in a few days, but some remain for weeks. They can cause what appears to be a type of vascular dementia years after surgery. Donepezil has shown some benefit. Emboli, such as clots, cholesterol crystals, and microspheres can be extruded through the walls of cerebral vessels, but there is no evidence yet that lipid emboli undergo such extravasation. PMID:20946471

  6. Review of nutrient actions on age-related macular degeneration.

    PubMed

    Zampatti, Stefania; Ricci, Federico; Cusumano, Andrea; Marsella, Luigi Tonino; Novelli, Giuseppe; Giardina, Emiliano

    2014-02-01

    The actions of nutrients and related compounds on age-related macular degeneration (AMD) are explained in this review. The findings from 80 studies published since 2003 on the association between diet and supplements in AMD were reviewed. Antioxidants and other nutrients with an effect on AMD susceptibility include carotenoids (lutein and zeaxanthin, β-carotene), vitamins (vitamin A, E, C, D, B), mineral supplements (zinc, copper, selenium), dietary fatty acids [monounsaturated fatty acids, polyunsaturated fatty acids (PUFA both omega-3 PUFA and omega-6 PUFA), saturated fatty acids and cholesterol], and dietary carbohydrates. The literature revealed that many of these antioxidants and nutrients exert a protective role by functioning synergistically. Specifically, the use of dietary supplements with targeted actions can provide minimal benefits on the onset or progression of AMD; however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression. PMID:24461310

  7. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, VOLUME 77, RBRC SCIENTIFIC REVIEW COMMITTEE MEETING, OCTOBER 10-12, 2005

    SciTech Connect

    SAMIOS, N.P.

    2005-10-10

    The eighth evaluation of the RIKEN BNL Research Center (RBRC) took place on October 10-12, 2005, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Jean-Paul Blaizot, Professor Makoto Kobayashi, Dr. Akira Masaike, Professor Charles Young Prescott (Chair), Professor Stephen Sharpe (absent), and Professor Jack Sandweiss. We are grateful to Professor Akira Ukawa who was appointed to the SRC to cover Professor Sharpe's area of expertise. In addition to reviewing this year's program, the committee, augmented by Professor Kozi Nakai, evaluated the RBRC proposal for a five-year extension of the RIKEN BNL Collaboration MOU beyond 2007. Dr. Koji Kaya, Director of the Discovery Research Institute, RIKEN, Japan, presided over the session on the extension proposal. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on higher research efforts. In addition, a special session was held in connection with the RBRC QCDSP and QCDOC supercomputers. Professor Norman H. Christ, a collaborator from Columbia University, gave a presentation on the progress and status of the project, and Professor Frithjof Karsch of BNL presented the first physics results from QCDOC. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.

  8. Aging, circadian rhythms and depressive disorders: a review

    PubMed Central

    Campos Costa, Inês; Nogueira Carvalho, Hugo; Fernandes, Lia

    2013-01-01

    Introduction: Aging is typically associated with impairing behavioral patterns that are frequently and inappropriately seen as normal. Circadian rhythm changes and depressive disorders have been increasingly proposed as the two main overlapping and interpenetrating changes that take place in older age. This study aims to review the state of the art on the subject concerning epidemiology, pathophysiological mechanism, clinical findings and relevance, as well as available treatment options. Materials and Methods: A nonsystematic review of all English language PubMed articles published between 1995 and December 2012 using the terms “circadian rhythms”, “mood disorders”, “depression”, “age”, “aging”, “elderly” and “sleep”. Discussion and conclusion: Sleep disorders, mainly insomnia, and depression have been demonstrated to be highly co-prevalent and mutually precipitating conditions in the elderly population. There is extensive research on the pathophysiological mechanisms through which age conditions circadian disruption, being the disruption of the Melatonin system one of the main changes. However, research linking clearly and unequivocally circadian disruption and mood disorders is still lacking. Nonetheless, there are consistently described molecular changes on shared genes and also several proposed pathophysiological models linking depression and sleep disruption, with clinical studies also suggesting a bi-directional relationship between these pathologies. In spite of this suggested relation, clinical evaluation of these conditions in elderly patients consistently reveals itself rather complicated due to the frequently co-existing co-morbidities, some of them having been demonstrated to alter sleep and mood patters. This is the case of strokes, forms of dementia such as Alzheimer and Parkinson, several neurodegenerative disorders, among others. Although there are to the present no specific treatment guidelines, available treatment

  9. Literature search strategies to comply with institutional animal care and use committee review requirements.

    PubMed

    Nesdill, Daureen; Adams, Kristina M

    2011-01-01

    Under the US Animal Welfare Act, principal investigators who propose to use animals in their research must demonstrate that they have considered alternatives to potentially painful or distressful procedures when submitting applications to Institutional Animal Care and Use Committees (IACUCs). IACUCs requires that applicants conduct a current literature search to determine if alternatives are available to substitute the proposed animal use and, if the proposed study involves pain or distress, that more humane procedures, as they are described in the literature, be considered. This paper suggests literature search strategies that can be considered for use in order to comply with this IACUC requirement.

  10. "Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics Committee on Drugs.

    PubMed

    1997-02-01

    Because of an increasing number of reports of adverse reactions associated with pharmaceutical excipients, in 1985 the Committee on Drugs issued a position statement recommending that the Food and Drug Administration mandate labeling of over-the-counter and prescription formulations to include a qualitative list of inactive ingredients. However, labeling of inactive ingredients remains voluntary. Adverse reactions continue to be reported, although some are no longer considered clinically significant, and other new reactions have emerged. The original statement, therefore, has been updated and its information expanded.

  11. 77 FR 32649 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ...: Center for Scientific Review Special Emphasis Panel; Drug Discovery and Mechanisms of Antimicrobial... Review Special Emphasis Panel; Small Business: Drug Discovery for Aging, Neuropsychiatric and Neurologic... . Name of Committee: Center for Scientific Review Special Emphasis Panel; Fellowships: Brain...

  12. 77 FR 53228 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ...)(3), for review and findings of fact related to the identity or cultural affiliation of human remains..., pursuant to 25 U.S.C. 3006 (c)(3), for review and findings of fact related to the identity or cultural...), for review and findings of fact related to the identity or cultural affiliation of human remains...

  13. Use of Serogroup B Meningococcal Vaccines in Persons Aged ≥10 Years at Increased Risk for Serogroup B Meningococcal Disease: Recommendations of the Advisory Committee on Immunization Practices, 2015.

    PubMed

    Folaranmi, Temitope; Rubin, Lorry; Martin, Stacey W; Patel, Manisha; MacNeil, Jessica R

    2015-06-12

    In October 2014, the Food and Drug Administration (FDA) licensed the first serogroup B meningococcal (MenB) vaccine (MenB-FHbp [Trumenba, Wyeth Pharmaceuticals, Inc.]) as a 3-dose series. In January 2015, FDA licensed a second MenB vaccine (MenB-4C [Bexsero, Novartis Vaccines]) as a 2-dose series. Both vaccines were approved for use in persons aged 10-25 years. Following outbreaks of serogroup B meningococcal disease on two college campuses in 2013, both MenB vaccines were granted Breakthrough Therapy designations, which expedites drug development and review by FDA, and were licensed based on accelerated approval regulations. On February 26, 2015, the Advisory Committee on Immunization Practices (ACIP) recommended use of MenB vaccines among certain groups of persons aged ≥10 years who are at increased risk for serogroup B meningococcal disease. This report summarizes information on MenB administration and provides recommendations and guidance for use of these vaccines among persons aged ≥10 years in certain groups who are at increased risk for serogroup B meningococcal disease, and reviews the evidence considered by ACIP to make these recommendations. Recommendations for broader use of MenB vaccines in adolescents and college students will be considered separately by ACIP.

  14. Love Canal Emergency Declaration Area habitability study. Volume 5. Peer review summary: TRC (Technical Review Committee) responses. Final report

    SciTech Connect

    Not Available

    1988-07-01

    Environmental studies were conducted to provide data that could be used by the Commissioner of Health for the State of New York in determining whether the Emergency Declaration Area surrounding the Love Canal hazardous-waste site is habitable. These volumes (II through IV) were reviewed by a peer-review panel of expert scientists. The scientists concluded that each of the three environmental studies was well planned and well executed. Volume V summarizes the peer review and gives additional information or clarifications as requested during the peer review. Volume V also provides additional supplemental statistical analyses requested by the peer reviewer panel.

  15. Traveller's thrombosis: a review of deep vein thrombosis associated with travel. The Air Transport Medicine Committee, Aerospace Medical Association.

    PubMed

    Bagshaw, M

    2001-09-01

    There is an increasing suspicion among the travelling public and the international media of an association between the occurrence of deep venous thrombosis (DVT) and air travel. It was noted by the UK House of Lords Select Committee on Science and Technology that up to 20% of the total population may have some degree of increased clotting tendency. It follows that some air travellers are at risk of developing DVT when, or soon after, travelling. There have been no epidemiological studies published which show a statistically significant increase in cases of DVT when travelling in the absence of pre-existing risk factors. The literature was reviewed. Current evidence indicates that any association between symptomatic DVT and travel by air is weak, and the incidence is less than the impression given by recent media publicity.

  16. Review of the thermal energy standards for manufactured housing proposed by the Manufactured Housing Institute Consensus Committee

    SciTech Connect

    Conner, C.C.

    1992-02-01

    Congress passed legislation that requires the US Department of Housing and Urban Development (HUD) to revise the energy efficiency standards for manufactured housing contained in the Manufactured Home Construction and Safety Standards (MHCSS). The Manufactured Housing Institute's Consensus Committee (MHICC) proposed revised standards to HUD based on an analysis contained in a 1989 report by E. Levy. This document is primarily a review of the Levy report, including the methods and inputs to that analysis. The approach to be used in developing the revised standard was specified by Congress as a cost-benefit analysis in which the costs of energy efficiency measures (EEM) were balanced against the benefits of energy savings. The resulting optimum specified an overall level of energy efficiency in terms of a maximum allowable building shell U-value (overall thermal transmittance) that produced the lowest life-cycle cost to the owner of a manufactured home. In his 1989 analysis, this was the general approach used by Levy.

  17. 14 CFR 121.1105 - Aging airplane inspections and records reviews.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aging airplane inspections and records... Improvements § 121.1105 Aging airplane inspections and records reviews. (a) Applicability. This section applies... holder that the Administrator has completed the aging airplane inspection and records review required...

  18. 14 CFR 121.1105 - Aging airplane inspections and records reviews.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aging airplane inspections and records... Improvements § 121.1105 Aging airplane inspections and records reviews. (a) Applicability. This section applies... holder that the Administrator has completed the aging airplane inspection and records review required...

  19. 14 CFR 121.1105 - Aging airplane inspections and records reviews.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aging airplane inspections and records... Improvements § 121.1105 Aging airplane inspections and records reviews. (a) Applicability. This section applies... holder that the Administrator has completed the aging airplane inspection and records review required...

  20. 14 CFR 121.1105 - Aging airplane inspections and records reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aging airplane inspections and records... Improvements § 121.1105 Aging airplane inspections and records reviews. (a) Applicability. This section applies... holder that the Administrator has completed the aging airplane inspection and records review required...

  1. 14 CFR 121.1105 - Aging airplane inspections and records reviews.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aging airplane inspections and records... Improvements § 121.1105 Aging airplane inspections and records reviews. (a) Applicability. This section applies... holder that the Administrator has completed the aging airplane inspection and records review required...

  2. Genetic screening: programs, principles, and research--thirty years later. Reviewing the recommendations of the Committee for the Study of Inborn Errors of Metabolism (SIEM).

    PubMed

    Simopoulos, A P

    2009-01-01

    Screening programs for genetic diseases and characteristics have multiplied in the last 50 years. 'Genetic Screening: Programs, Principles, and Research' is the report of the Committee for the Study of Inborn Errors of Metabolism (SIEM Committee) commissioned by the Division of Medical Sciences of the National Research Council at the National Academy of Sciences in Washington, DC, published in 1975. The report is considered a classic in the field worldwide, therefore it was thought appropriate 30 years later to present the Committee's modus operandi and bring the Committee's recommendations to the attention of those involved in genetics, including organizational, educational, legal, and research aspects of genetic screening. The Committee's report anticipated many of the legal, ethical, economic, social, medical, and policy aspects of genetic screening. The recommendations are current, and future committees should be familiar with them. In 1975 the Committee stated: 'As new screening tests are devised, they should be carefully reviewed. If the experimental rate of discovery of new genetic characteristics means an accelerating rate of appearance of new screening tests, now is the time to develop the medical and social apparatus to accommodate what later on may otherwise turn out to be unmanageable growth.' What a prophetic statement that was. If the Committee's recommendations had been implemented on time, there would be today a federal agency in existence, responsive and responsible to carry out the programs and support research on various aspects of genetic screening, including implementation of a federal law that protects consumers from discrimination by their employers and the insurance industry on the basis of genetic information.

  3. Aberdeen Area Indian Health Service Environmental Health Program Review Conducted by: Indian Health Committee of the National Environmental Health Association (Aberdeen, South Dakota, May 23-27, 1977).

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Aberdeen, SD. Aberdeen Area Office.

    The Indian Health Committee met in Aberdeen, South Dakota, during the week of May 23, 1977 to (1) review the environmental health services provided to the tribal units on the 15 Indian reservations located in North Dakota, South Dakota, Nebraska and Iowa, and (2) make recommendations for improvement or expansion of current programs, if needed. The…

  4. Ensuring Resident Competence: A Narrative Review of the Literature on Group Decision Making to Inform the Work of Clinical Competency Committees.

    PubMed

    Hauer, Karen E; Cate, Olle Ten; Boscardin, Christy K; Iobst, William; Holmboe, Eric S; Chesluk, Benjamin; Baron, Robert B; O'Sullivan, Patricia S

    2016-05-01

    Background The expectation for graduate medical education programs to ensure that trainees are progressing toward competence for unsupervised practice prompted requirements for a committee to make decisions regarding residents' progress, termed a clinical competency committee (CCC). The literature on the composition of these committees and how they share information and render decisions can inform the work of CCCs by highlighting vulnerabilities and best practices. Objective We conducted a narrative review of the literature on group decision making that can help characterize the work of CCCs, including how they are populated and how they use information. Methods English language studies of group decision making in medical education, psychology, and organizational behavior were used. Results The results highlighted 2 major themes. Group member composition showcased the value placed on the complementarity of members' experience and lessons they had learned about performance review through their teaching and committee work. Group processes revealed strengths and limitations in groups' understanding of their work, leader role, and information-sharing procedures. Time pressure was a threat to the quality of group work. Conclusions Implications of the findings include the risks for committees that arise with homogeneous membership, limitations to available resident performance information, and processes that arise through experience rather than deriving from a well-articulated purpose of their work. Recommendations are presented to maximize the effectiveness of CCC processes, including their membership and access to, and interpretation of, information to yield evidence-based, well-reasoned judgments.

  5. Science, Technology, and Diplomacy in the Age of Interdependence: Committee on International Relations, U.S. House of Representatives. [Committee Print].

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on International Relations.

    Provided is a congressional study which analyzes the interactions between contemporary practice of science, technology, and the formulation and conduct of U.S. foreign policy. Six cases illustrating the interaction of science, technology, and diplomacy are reviewed and six general issues, including topics such as nuclear power, seabed resources,…

  6. Nongenetic Determinants of Age at Menarche: A Systematic Review

    PubMed Central

    2014-01-01

    Background. The acceleration of pubertal development is an important medical and social problem, as it may result in increased morbidity and mortality in later life. This systematic review summarizes relevant data about nongenetic factors, which contribute to age at menarche (AAM), and suggests those which may be the most important. Methods. The available literature from 1980 till July 2013 was searched using PubMed and Google Scholar databases. Finally, 154 papers were selected for the analysis. Results. Environmental factors, which may affect AAM, vary in populations of different ethnicity. The prenatal, infancy, and early childhood periods are the most susceptible to these factors. Body weight, high animal protein intake, family stressors (e.g., single parenting), and physical activity seem to influence AAM in most populations. Conclusions. The data about influence of nongenetic factors on AAM are still inconsistent. The factors affecting prenatal and early childhood growth seem to have a larger effect on further sexual maturation. Further studies are needed in order to validate the association between other environmental determinants and AAM in different ethnical groups. PMID:25050345

  7. Forming a Consumer Advisory Committee.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. National Library Service for the Blind and Physically Handicapped.

    This publication contains guidelines for the formation of consumer advisory committees to aid in the improvement of library services to blind and physically handicapped individuals. The purpose, justification, and composition of such committees are reviewed, as well as the tasks of organizing the committee's first meeting and providing…

  8. 40 CFR 105.12 - How is the awards review committee selected?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based...

  9. 40 CFR 105.12 - How is the awards review committee selected?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based...

  10. 40 CFR 105.12 - How is the awards review committee selected?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based on staff availability, and may be one person....

  11. Review of the US Consumer Product Safety Commission's health effects and exposure assessment documents on nitrogen dioxide. Report of the Clean Air Scientific Advisory Committee. Final report

    SciTech Connect

    Not Available

    1988-05-09

    At the request of the Consumer Product Safety Commission, the Clean Air Scientific Advisory Committee conducted a review on the potential health hazards associated with exposure to 0.1 to 1.0 ppm nitrogen dioxide generated by unvented indoor combustion sources. The committee concluded that: (1) repeated peak exposures at concentrations of 0.3 ppm of nitrogen dioxide may cause health effects in some individuals; (2) the population groups that appear most sensitive to nitrogen dioxide exposure include children, chronic bronchitics, asthmatics, and individuals with emphysema; and (3) the most direct evidence regarding lung damage associated with nitrogen dioxide is obtained from animal studies.

  12. A review of the most commonly used dental age estimation techniques.

    PubMed

    Willems, G

    2001-06-01

    This review of literature provides an overview of the most commonly used dental age estimation techniques and focuses on dental age estimation scoring systems in children and adults. In order to obtain a more reliable and reproducible age estimation the forensic odontologist should use several of these available methods whenever an age estimation in the living or dead is required. PMID:11494678

  13. AgRISTARS. Project management report: Program review presentation to level 1, interagency coordination committee

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The AgRISTARS supporting research projects in the areas of data systems, scene radiation, and pattern recognition are reviewed. The objectives, activities, and accomplishments of FY-80 and the objectives and status of FY-81 programs are described.

  14. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 3. Evaluation of potential for pipe breaks

    SciTech Connect

    Not Available

    1984-11-01

    The Executive Director for Operations (EDO) in establishing the Piping Review Committee concurred in its overall scope that included an evaluation of the potential for pipe breaks. The Pipe Break Task Group has responded to this directive. This report summarizes a review of regulatory documents and contains the Task Group's recommendations for application of the leak-before-break (LBB) approach to the NRC licensing process. The LBB approach means the application of fracture mechanics technology to demonstrate that high energy fluid piping is very unlikely to experience double-ended ruptures or their equivalent as longitudinal or diagonal splits. The Task Group's reommendations and discussion are founded on current and ongoing NRC staff actions as presented in Section 3.0 of this report. Additional more detailed comments and discussion are presented in Section 5.0 and in Appendices A and B. The obvious issues are the reexamination of the large pipe break criteria and the implications of any changes in the criteria as they influence items such as jet loads and pipe whip. The issues have been considered and the Task Group makes the following recommendations.

  15. Inter-rater reliability of surgical reviews for AREN03B2: A COG renal tumor committee study✩

    PubMed Central

    Hamilton, Thomas E.; Barnhart, Douglas; Gow, Kenneth; Ferrer, Fernando; Kandel, Jessica; Glick, Richard; Dasgupta, Roshni; Naranjo, Arlene; He, Ying; Gratias, Eric; Geller, James; Mullen, Elizabeth; Ehrlich, Peter

    2014-01-01

    Purpose The Children's Oncology Group (COG) renal tumor study (AREN03B2) requires real-time central review of radiology, pathology, and the surgical procedure to determine appropriate risk-based therapy. The purpose of this study was to determine the inter-rater reliability of the surgical reviews. Methods Of the first 3200 enrolled AREN03B2 patients, a sample of 100 enriched for blood vessel involvement, spill, rupture, and lymph node involvement was selected for analysis. The surgical assessment was then performed independently by two blinded surgical reviewers and compared to the original assessment, which had been completed by another of the committee surgeons. Variables assessed included surgeon-determined local tumor stage, overall disease stage, type of renal procedure performed, presence of tumor rupture, occurrence of intraoperative tumor spill, blood vessel involvement, presence of peritoneal implants, and interpretation of residual disease. Inter-rater reliability was measured using the Fleiss' Kappa statistic two-sided hypothesis tests (Kappa, p-value). Results Local tumor stage correlated in all 3 reviews except in one case (Kappa = 0.9775, p < 0.001). Similarly, overall disease stage had excellent correlation (0.9422, p < 0.001). There was strong correlation for type of renal procedure (0.8357, p < 0.001), presence of tumor rupture (0.6858, p < 0.001), intraoperative tumor spill (0.6493, p < 0.001), and blood vessel involvement (0.6470, p < 0.001). Variables that had lower correlation were determination of the presence of peritoneal implants (0.2753, p < 0.001) and interpretation of residual disease status (0.5310, p < 0.001). Conclusion The inter-rater reliability of the surgical review is high based on the great consistency in the 3 independent review results. This analysis provides validation and establishes precedent for real-time central surgical review to determine treatment assignment in a risk-based stratagem for multimodal cancer therapy

  16. Preparing for Retirement: Crisis or Challenge? Hearing Before the Subcommittee on Retirement Income and Employment of the Select Committee on Aging, House of Representatives, Ninety-Fifth Congress, Second Session, June 19, 1978.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    The materials contained in these hearings represent the statements of witnesses before one of the Subcommittees of the Committee on Aging of the House of Representatives. Witnesses include members of Congress, persons affiliated with the Administration on Aging and the U.S. Civil Service Commission, representatives of various labor unions, those…

  17. The Older Americans Act and Its Application to Native Americans. Hearing before the Special Committee on Aging. United States Senate, Ninety-Ninth Congress, Second Session (Oklahoma City, OK, June 28, 1986).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    Three panels appearing before the Senate Special Committee on Aging discuss the sensitivity of the Administration on Aging to Native Americans, coordination of services between Title II and Title VI of the Older Americans Act, and availability of services under the act. Witnesses recommend language be included in the reauthorization of the Older…

  18. Proinflammation of aging central arteries: a mini-review.

    PubMed

    Wang, Mingyi; Monticone, Robert E; Lakatta, Edward G

    2014-01-01

    Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. an increase in local angiotensin II signaling that induces an inflammatory phenotypic shift of endothelial and smooth muscle cells. Thus, interventions to restrict proinflammatory signaling are a rational approach to delay or prevent age-associated adverse arterial remodeling.

  19. 75 FR 70028 - Native American Graves Protection and Repatriation Review Committee: Meeting 2253-665

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... and findings of fact related to the identity or cultural affiliation of human remains or other.... 3006 (c)(3), for review and findings of fact related to the identity or cultural affiliation of human... identity or cultural affiliation of human remains or other cultural items, or the return of such items....

  20. Mandatory Statewide Student Fees in California's Public Four-Year Colleges and Universities. Report of the Sunset Review Committee on Statewide Student Fee Policy under Senate Bill 195 (1985). Report 89-19.

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    The Student Fee Sunset Review Committee's recommendation to the California legislature regarding revisions to and extension of the existing student fee legislation originally enacted in 1985 is presented. The committee continues to support the fee policy as well as the proposed changes in fee legislation that it recommends. Part 1 covers…

  1. Mechanisms of the anorexia of aging-a review.

    PubMed

    Wysokiński, Adam; Sobów, Tomasz; Kłoszewska, Iwona; Kostka, Tomasz

    2015-08-01

    Many, even healthy, older people fail to adequately regulate food intake and experience loss of weight. Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). However, exact mechanisms of the anorexia of aging remain to be elucidated. Many neurobiological mechanisms may be secondary to age-related changes in body composition and not associated with anorexia per se. Therefore, further studies on pathophysiological mechanisms of the anorexia of aging should employ accurate measurement of body fat and lean mass. The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. Since this symptom can lead to dramatic consequences, early identification and effective interventions are needed. One of the most important goals in the geriatric care is to optimize nutritional status of the elderly.

  2. Computational physics and applied mathematics capability review June 8-10, 2010 (Advance materials to committee members)

    SciTech Connect

    Lee, Stephen R

    2010-01-01

    (broadly defined) in a variety of settings, including particle transport, solvers, and plasma physics; (3) Monte Carlo - Monte Carlo was invented at Los Alamos, and this theme discusses these vitally important methods and their application in everything from particle transport, to condensed matter theory, to biology; (4) Molecular Dynamics - This theme describes the widespread use of molecular dynamics for a variety of important applications, including nuclear energy, materials science, and biological modeling; (5) Discrete Event Simulation - The technical scope of this theme represents a class of complex system evolutions governed by the action of discrete events. Examples include network, communication, vehicle traffic, and epidemiology modeling; and (6) Integrated Codes - This theme discusses integrated applications (comprised of all of the supporting science represented in Themes 1-5) that are of strategic importance to the Laboratory and the nation. The laboratory has in approximately 10 million source lines of code in over 100 different such strategically important applications. Of these themes, four of them will be reviewed during the 2010 review cycle: Themes 1, 2, 3, and 6. Because these capability reviews occur every three years, Themes 4 and 5 will be reviewed in 2013, along with Theme 6 (which will be reviewed during each review, owing to this theme's role as an integrator of the supporting science represented by the other 5 themes). Yearly written status reports will be provided to the Capability Review Committee Chair during off-cycle years.

  3. Working Americans: Equality at Any Age. Hearing before the Special Committee on Aging, United States Senate, Ninety-Ninth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This report of a congressional hearing focuses on the Age Discrimination in Employment Act (ADEA), which permits forced retirement of American workers solely on the basis of age, that is, mandatory retirement at age 70. Testimony includes statements and prepared statements from a United States Representative, individuals who have been forced to…

  4. Constitutional limits on federal legislation practically compelling medical employment: Wong v Commonwealth; Selim v Professional Services Review Committee.

    PubMed

    Faunce, Thomas

    2009-10-01

    A recent decision by the High Court of Australia (Wong v Commonwealth; Selim v Professional Services Review Committee (2009) 236 CLR 573) (the PSR case) has not only clarified the scope of the Australian constitutional prohibition on "any form of civil conscription" in relation to federal legislation concerning medical or dental services (s 51xxiiiA), but has highlighted its importance as a great constitutional guarantee ensuring the mixed State-federal and public-private nature of medical service delivery in Australia. Previous decisions of the High Court have clarified that the prohibition does not prevent federal laws regulating the manner in which medical services are provided. The PSR case determined that the anti-overservicing provisions directed at bulk-billing general practitioners under Pt VAA of the Health Insurance Act 1973 (Cth) did not offend the prohibition. Importantly, the High Court also indicated that the s 51(xxiiiA) civil conscription guarantee should be construed widely and that it would invalidate federal laws requiring providers of medical and dental services (either expressly or by practical compulsion) to work for the federal government or any specified State, agency or private industrial employer. This decision is likely to restrict the capacity of any future federal government to restructure the Australian health care system, eg by implementing recommendations from the National Health and Hospitals Reform Commission for either federal government or private corporate control of presently State-run public hospitals.

  5. Agricultural (nonbiomedical) animal research outside the laboratory: a review of guidelines for institutional animal care and use committees.

    PubMed

    Granstrom, David E

    2003-01-01

    Challenges and published guidelines associated with appropriate care and use of farm animals in agricultural research conducted outside the laboratory are briefly reviewed. The Animal Welfare Act (Title 9 of the 2000 Code of Federal Regulations), which regulates the care and use of agricultural animals in biomedical research, does not include livestock and poultry used in agricultural research. Farm animal research funded (and thereby regulated) by the US Public Health Service is further discussed in the National Research Council's 1996 Guide for the Care and Use of Laboratory Animals. However, neither of these guidelines adequately addresses the unique attributes of research and teaching designed to improve production agriculture. That information is contained in the Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (the Ag Guide), published by the Federation of Animal Science Societies in 1999. The Ag Guide provides excellent general recommendations for agricultural animal research. It serves as an invaluable resource for institutional animal care and use committees, which attempt to balance the welfare of farm animals and the needs of those working to improve animal agriculture.

  6. Clinical review: Canadian National Advisory Committee on Blood and Blood Products - Massive Transfusion Consensus Conference 2011: report of the panel

    PubMed Central

    2011-01-01

    In June 2011 the Canadian National Advisory Committee on Blood and Blood Products sponsored an international consensus conference on transfusion and trauma. A panel of 10 experts and two external advisors reviewed the current medical literature and information presented at the conference by invited international speakers and attendees. The Consensus Panel addressed six specific questions on the topic of blood transfusion in trauma. The questions focused on: ratio-based blood resuscitation in trauma patients; the impact of survivorship bias in current research conclusions; the value of nonplasma coagulation products; the role of protocols for delivery of urgent transfusion; the merits of traditional laboratory monitoring compared with measures of clot viscoelasticity; and opportunities for future research. Key findings include a lack of evidence to support the use of 1:1:1 blood component ratios as the standard of care, the importance of early use of tranexamic acid, the expected value of an organized response plan, and the recommendation for an integrated approach that includes antifibrinolytics, rapid release of red blood cells, and a foundation ratio of blood components adjusted by results from either traditional coagulation tests or clot viscoelasticity or both. The present report is intended to provide guidance to practitioners, hospitals, and policy-makers. PMID:22188866

  7. The new seventh edition American Joint Committee on Cancer staging of cutaneous non-melanoma skin cancer: a critical review.

    PubMed

    Warner, Christina L; Cockerell, Clay J

    2011-06-01

    The seventh edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual includes a major revision of the staging protocol for cutaneous carcinomas. There are several significant improvements to the Tumor, Nodes, and Metastases (TNM) staging system, including consideration of high-risk factors within the primary T grade, a decrease in the tumor size threshold from 5 cm to 2 cm, improved stratification of patient lymph node status, as well as exclusion of Merkel cell carcinomas from the staging system for squamous cell carcinoma (SCC) and other cutaneous carcinomas. However, some important variables in cutaneous SCC were excluded from consideration. In addition, the AJCC Cancer Staging Manual makes some recommendations that will likely prove difficult to apply in clinical practice, particularly that Clark level, depth of invasion, and presence or absence of perineural invasion should be recorded for each peripheral SCC. In this review, we examine the new recommendations with an emphasis on their utility and practicality. PMID:21469759

  8. Effective committees.

    PubMed

    Collins, Jannette

    2012-03-01

    A committee is a group of people officially delegated to perform a function, such as investigating, considering, reporting, or acting on a matter. Some committees function like task forces and work on specific, time-limited projects. When the work is finished, the committees are no longer needed. These committees are called ad hoc committees. Other committees are standing committees. They are created by the standing orders, rules, by-laws, or regulations of an organization and exist and function indefinitely (eg, finance, membership, education, nomination). Both types of committees can form subcommittees if the workloads are heavy or complex in nature. Committees can be among the most important working forces of an organization. They serve as work units of the organization, taking work and breaking it into meaningful and manageable chunks. They efficiently carry out the work of the organization. Committee work should be a rewarding experience for both the members and the organization. Committees represent, involve, and serve members, as well as provide an important training ground for future leaders of an organization. New or inexperienced members can gain valuable insight into an organization and develop confidence by serving on committees. There are several key elements of effective committees, including (1) a clear, written purpose; (2) an effective committee chair; (3) thoughtfully appointed members; and (4) well-run meetings.

  9. Are research subjects adequately protected? A review and discussion of studies conducted by the Advisory Committee on Human Radiation Experiments.

    PubMed

    Kass, Nancy E; Sugarman, Jeremy

    1996-09-01

    In light of information uncovered about human radiation experiments conducted during the Cold War, an important charge for the Advisory Committee on Human Radiation Experiments was to assess the current state of protections for human research subjects. This assessment was designed to enhance the Committee's ability to make informed recommendations for the improvement of future policies and practices for the protection of research subjects. The Committee's examination of current protections revealed great improvement over those from the past, yet some problems remain. Although the data collected by the Committee highlight specific areas in need of attention, the Committee's work should be viewed in part as the beginning of a series of ongoing assessments of the adequacy and effectiveness of the protections afforded to human subjects.

  10. Assessment of Competence: The Accreditation Council for Graduate Medical Education/Residency Review Committee Perspective.

    PubMed

    Potts, John R

    2016-02-01

    Competency is an individual trait. As an agency that accredits programs and institutions, the Accreditation Council for Graduate Medical Education (ACGME) does not define or access competency. However, in the past 15 years the ACGME has promulgated several initiatives to aid programs in the assessment of the competence of their residents and fellows. Those initiatives include the Outcomes Project (which codified the competencies), the Milestones, and the Clinical Learning Environment Review Program. In the near future, the ACGME will implement an initiative by which programs can develop and study the results of competency-based residency curricula.

  11. School Age Populations Research Needs - NCS Dietary Assessment Literature Review

    Cancer.gov

    Drawing conclusions about the validity of available dietary assessment instruments in school age children is hampered by the differences in instruments, research design, reference methods, and populations in the validation literature.

  12. Radiological Indicators of Bone Age Assessment in Cephalometric Images. Review

    PubMed Central

    Durka-Zając, Magdalena; Mituś-Kenig, Maria; Derwich, Marcin; Marcinkowska-Mituś, Agata; Łoboda, Magdalena

    2016-01-01

    Summary The ability to assess bone age accurately is important and allows to diagnose the patient correctly and to plan orthodontic treatment appropriately. The aim of the work is to present views of different authors on the subject of using cephalometric images to determine bone age and its significance for conducting appropriate orthodontic treatment. Publications from the PubMed medical database were analyzed. Search criteria: bone age assessment, CVM method. Ultimately, 36 papers out of 1354 publications were selected. The research of many authors confirms the usefulness of various methods using cephalometric images to assess skeletal age. Currently, the CVM method devised by Baccetti et al. is the most frequently mentioned one in literature. It seems that bone age assessment methods based on evaluating the morphological structure of the cervical vertebrae in cephalometric images can clearly differentiate skeletal maturity in children regardless of their race or sex. Bearing in mind the constant technological progress in medicine and stomatology, bone age assessment methods need to be perfected in order to alleviate their impact on the patient as much as possible. PMID:27536337

  13. Radiological Indicators of Bone Age Assessment in Cephalometric Images. Review.

    PubMed

    Durka-Zając, Magdalena; Mituś-Kenig, Maria; Derwich, Marcin; Marcinkowska-Mituś, Agata; Łoboda, Magdalena

    2016-01-01

    The ability to assess bone age accurately is important and allows to diagnose the patient correctly and to plan orthodontic treatment appropriately. The aim of the work is to present views of different authors on the subject of using cephalometric images to determine bone age and its significance for conducting appropriate orthodontic treatment. Publications from the PubMed medical database were analyzed. Search criteria: bone age assessment, CVM method. Ultimately, 36 papers out of 1354 publications were selected. The research of many authors confirms the usefulness of various methods using cephalometric images to assess skeletal age. Currently, the CVM method devised by Baccetti et al. is the most frequently mentioned one in literature. It seems that bone age assessment methods based on evaluating the morphological structure of the cervical vertebrae in cephalometric images can clearly differentiate skeletal maturity in children regardless of their race or sex. Bearing in mind the constant technological progress in medicine and stomatology, bone age assessment methods need to be perfected in order to alleviate their impact on the patient as much as possible. PMID:27536337

  14. Multicentre trials review process by research ethics committees in Spain: where do they stand before implementing the new European regulation?

    PubMed Central

    Dal-Re, R; Ortega, R; Morejon, E

    2005-01-01

    Objectives: To review the performance of research ethics committees (RECs) in Spain in assessing multicentre clinical trial (MCT) drug protocols, and to evaluate if they would comply with the requirements of the new EU Directive to be implemented by May 2004. Design and setting: Prospective study of applications of MCT submitted to RECs. Main measurements: Protocol related features and evaluation process dynamics. Results: 187 applications (24 protocols, 18 study drugs) to be performed in 114 centres, were reviewed by 62 RECs. RECs had a median number of 14 members, of which three were lay members. All applications were approved except four which were however approved by the other RECs involved. The median times from submission to approval and from submission to reception at the sponsor's offices were 48 and 62 days, respectively. In 55% (101/183) of all applications approved, 41 RECs raised 307 queries, 40% of these were protocol related issues, and 38% related to the patients' information sheets. RECs charging an evaluation fee in advance and applications with no queries raised were statistically significantly associated with shorter evaluation times. However, there is a gap of at least 1.5 weeks between the date of the meeting and the reception of the approval letter in the sponsor's office. Conclusions: Evaluating MCT protocols by RECs is a time consuming process. Needing 1.5 weeks for communicating the decision taken by RECs to the sponsor suggests serious administrative shortcomings within most RECs. By significantly reducing the time for communication of their decisions, the majority of RECs would comply with the Directive requirement of a maximum 60 day period for the assessment of MCT. PMID:15923484

  15. Review of laboratory programs for women Points-of-Contact Committee

    SciTech Connect

    Duke, D.; Magrini, K.; McLane, V.; Wieda, K.

    1995-06-01

    The mission of the DOE Review of Laboratory Programs for Women is to: provide DOE and its Laboratories with effective strategies, targeting women, for establishing aggressive outreach programs which improve the access of women to careers in science, engineering, and mathematics. Ensure that the Department and its Laboratories are exemplary places of employment by providing programs which enhance opportunity, remove barriers, and assist women in achieving full professional development. A survey of the DOE facilities was undertaken by the Points-of-Contact for the DOE Review of Laboratory Programs for Women in order to gather data to be used as a baseline against which to measure future progress. We plan to look at current programs already in place and evaluate them with a view to deciding which programs are most effective, and selecting model programs suitable for implementation at other facilities. The survey focused on four areas: statistical data, laboratory policy, formal and informal programs which affect the quality of life in the work environment, and career development and advancement, and educational programs. Although this report focuses on women, the problems discussed affect all DOE facility employees.

  16. 76 FR 4925 - Center for Scientific Review; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Committee: Cell Biology Integrated Review Group; Cellular Mechanisms in Aging and Development Study Section... limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos....

  17. 75 FR 33626 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ..., Stress and Aging. Date: July 9, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflicts: Asthma and...

  18. 77 FR 64314 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... National Institute of Standards and Technology Advisory Committee on Earthquake Hazards Reduction Meeting... meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction (ACEHR or Committee), will meet... needs for existing buildings, to review the National Earthquake Hazards Reduction Program (NEHRP)...

  19. Clinical ethics committee.

    PubMed Central

    Thornton, J. G.; Lilford, R. J.

    1995-01-01

    An informal clinical ethics committee was set up to advise on ethical problems in prenatal diagnosis in Leeds. It was used twice in six months but was not called on again in the subsequent year, and we describe this experience. In North America similar committees are often used to advise on clinical moral dilemmas, and we review the published evidence from there and discuss some of the advantages and problems. Our committee's advice may have altered clinicians' actions considerably, but perhaps doctors in Britain are not yet ready to surrender this aspect of clinical autonomy. PMID:7549638

  20. Impact of oestrogen deficiency and aging on tendon: concise review

    PubMed Central

    Frizziero, Antonio; Vittadini, Filippo; Gasparre, Giuseppe; Masiero, Stefano

    2014-01-01

    Summary The knowledge about tendons and tenocyte biological behaviour during aging and, especially, oestrogen deficiency is limited. Women differ from men with regard to muscle and tendon, most likely due to differences in sex hormones activity and tissue response. To-date the interest in metabolic factors that may induce tendon disorders is growing. The aim of this paper is to elucidate the current findings in the correlation between oestrogen deficiency, aging and tendon pathology and to encourage future researches to ameliorate assessment and management of tendinopathies in postmenopausal women. PMID:25489550

  1. A new age of peer reviewed scientific journals

    PubMed Central

    Adler, John R.

    2012-01-01

    The principles of peer reviewed scientific publications date back two and one-half centuries to the origins of Medical Essays and Observations published by the Royal Society of Edinburgh (1731). This year (2012) is notable in that perhaps the most prestigious and best-known medical journal, the New England Journal of Medicine, crossed the second century mark. The methodologies of peer review have undeniably served medicine well and helped to usher in unimaginable advances in human health. Despite such illustrious history, the winds of change are in the air. PMID:23230526

  2. The Status of School-Age Child Care in Florida: An Oversight Report Prepared for the Education K-12 Committee.

    ERIC Educational Resources Information Center

    Florida House of Representatives, Tallahassee. Committee on Education, K-12.

    This comprehensive report provides current information on the status of school age child care in Florida, an overview of Florida Statutes, a summary of benefits and problems with state involvement, and recommendations for action. An estimated 138,000 children ages 5 to 13 in Florida may be without care every day after school. Florida's school…

  3. Aging and the Work Force: Human Resource Strategies. An Information Paper Prepared for Use by the Special Committee on Aging. United States Senate, Ninety-Seventh Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This information paper explores the need for age-neutral functional criteria in the human resources management system and the need for managers to review currently accepted employment policies. Population patterns, labor force profiles, and labor force projections are reviewed. The paper examines the effect of retirement policies and considers…

  4. A review on role of prakriti in aging.

    PubMed

    Purvya, Mahesh Chand; Meena, M S

    2011-01-01

    Ayurveda is an eternal science with absolute principles, and prakriti is one of these. It plays an important role in the selection and establishment of every factor for which a person is going to interact from conception till death, e.g. lifestyle, diet planning, etc. Prakriti stands for nature of the body in terms of dosha and is decided at the time of conception according to the predominance of dosha. It does not change during the whole life and is responsible for the physical and mental characteristics of an individual. This prakriti is of seven types according to tridosha. The individuals of specific prakriti exhibit biological variations in terms of structure, function, behavior, individual response to internal and external environmental stimuli, susceptibility to different diseases, etc. Aging is a process of decaying and included in natural diseases. In our body, Pitta or Agni is responsible for the various types of pathological conditions. Although aging is a natural pathological condition, Pitta plays an important role in its causation like other pathological conditions. It is clearly indicated in Charak samhita that persons having Pitta predominance personality tend to suffer early with decaying process and other changes of aging. Through this article, we have made an attempt to reevaluate the interrelationships between prakriti and aging. PMID:22131753

  5. Review of "Teachers in the Age of Digital Instruction"

    ERIC Educational Resources Information Center

    Huerta, Luis A.

    2012-01-01

    The Fordham Institute's "Teachers in the Age of Digital Instruction" is an advocacy document outlining a vision for how technology might transform the teaching profession. The report's rationale is based on claims that the current education system lacks the capacity to support the revolutionary changes needed to unleash the technological…

  6. Free and Compulsory School Age Requirements. ECS 50-State Reviews

    ERIC Educational Resources Information Center

    Aragon, Stephanie

    2015-01-01

    Policymakers across the nation continue to push for expanded free and compulsory school age requirements. More states are considering granting students earlier access to a free education so that they can begin their academic pursuits earlier in life. Similarly, every year a number of states consider extending the upper limit for compulsory school…

  7. Gender, ageing & carework in East and Southern Africa: A review

    PubMed Central

    Seeley, Janet

    2016-01-01

    An estimated 58 million persons aged 60-plus live in sub-Saharan Africa; by 2050 that number will rise sharply to 215 million. Older Africans traditionally get care in their old age from the middle generation. But in East and Southern Africa, HIV has hollowed out that generation, leaving many older persons to provide care for their children’s children without someone to care for him or herself in old age. Simultaneously, the burden of disease among older persons is changing in this region. The result is a growing care deficit. This article examines the existing literature on care for and by older persons in this region, highlighting understudied aspects of older persons’ experiences of ageing and care – including the positive impacts of carework, variation in the region, and the role of resilience and pensions. We advance a conceptual framework of gendered identities – for both men and women – and intergenerational social exchange to help focus and understand the complex interdependent relationships around carework, which are paramount in addressing the needs of older persons in the current care deficit in this region, and the Global South more generally. PMID:25947225

  8. AGU Committees

    NASA Astrophysics Data System (ADS)

    Administrative Committees are responsible for those functions required for the overall performance or well-being of AGU as an organization. These committees are Audit and Legal Affairs, Budget and Finance*, Development, Nominations*, Planning, Statutes and Bylaws*, Tellers.Operating Committees are responsible for the policy direction and operational oversight of AGU's primary programs. The Operating Committees are Education and Human Resources, Fellows*, Information Technology, International Participation*, Meetings, Public Affairs, Public Information, Publications*.

  9. SAM Technical Review Committee Final Report: Summary and Key Recommendations from the Onsite TRC Meeting Held April 22-23, 2013

    SciTech Connect

    Blair, N.; Dobos, S.; Janzou, S.; Gilman, P.; Freeman, J.; Kaffine, L.

    2013-08-01

    The System Advisor Model (SAM) is a broad and robust set of models and frameworks for analyzing both system performance and system financing. It does this across a range of technologies dominated by solar technologies including photovoltaics (PV) and concentrated solar power (CSP). The U.S. Department of Energy (DOE) Solar Energy Technology Program requested the SAM development team to review the photovoltaic performance modeling with the development community and specifically, with the independent engineering community. The report summarizes the major effort for this technical review committee (TRC).

  10. 22 CFR 8.5 - Creation of a committee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.5 Creation of a committee... memorandum to the Advisory Committee Management Officer setting forth the purpose, organization (including... committee. (b) The Advisory Committee Management Officer will review the request and will make an...

  11. Managing the aging man in Asia: a review.

    PubMed

    Tong, Seng Fah; Ho, Christopher; Tan, Hui Meng

    2011-01-01

    The aging man is becoming a major burden to Asian countries because of the current poor health status of Asian men and the aging Asian population. Life expectancy at birth for men is shorter than women by an average of 4 years in Asian countries and major causes of death are cardiovascular disease, cancers, injuries and infections. However, there are considerable variations between Asian countries because of great disparity in socioeconomic status. Male-specific disorders, such as male sexual health and urological conditions, are other major health burdens because they have a great impact on men's quality of life. More importantly, many risk factors to the causes of mortality and morbidities, such as high-risk behavior and smoking, can be improved with health promotion and early intervention. The current evidence suggests that the poor health status of men is the result of their poor health care utilization, negative health-seeking behavior, the adverse social environment for men and gender-insensitive health care delivery. However, much evidence is still needed as Asian countries have great diversity in culture, societal values and men's needs. Asian time-tested wisdom on a balanced healthy lifestyle to longevity should be explored as potential men's health promotional programs. Taking into account Asian men's health-care needs, a gender-streamlined approach and man-friendly health care delivery should be on the national agenda in managing the aging man. PMID:20969645

  12. A Review of the Aging Process and Facilities Topic.

    PubMed

    Jornitz, Maik W

    2015-01-01

    Aging facilities have become a concern in the pharmaceutical and biopharmaceutical manufacturing industry, so much that task forces are formed by trade organizations to address the topic. Too often, examples of aging or obsolete equipment, unit operations, processes, or entire facilities have been encountered. Major contributors to this outcome are the failure to invest in new equipment, disregarding appropriate maintenance activities, and neglecting the implementation of modern technologies. In some cases, a production process is insufficiently modified to manufacture a new product in an existing process that was used to produce a phased-out product. In other instances, manufacturers expanded the facility or processes to fulfill increasing demand and the scaling occurred in a non-uniform manner, which led to non-optimal results. Regulatory hurdles of post-approval changes in the process may thwart companies' efforts to implement new technologies. As an example, some changes have required 4 years to gain global approval. This paper will address cases of aging processes and facilities aside from modernizing options.

  13. Lifelong Learning for an Aging Society. An Information Paper Prepared for Use by the Special Committee on Aging. United States Senate, 102d Congress, 1st Session. Committee Print.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This report is an introduction to the concept of lifelong learning as a key to unlocking resources for an aging society. It describes a myriad of learning programs for older adults, from those provided by giant companies, to those conducted by small community centers, to those developed and run by elderly persons themselves. Programs are described…

  14. Conference Committees: Conference Committees

    NASA Astrophysics Data System (ADS)

    2009-09-01

    International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

  15. Cataract Surgery: Fraud, Waste, and Abuse. A Report by the Chairman of the Subcommittee on Health and Long-Term Care of the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This report is a summary of the findings from the Subcommittee on Health and Long-Term Care of the United States House of Representatives Select Committee on Aging investigation of cataract surgery and the use of intraocular lenses (IOL's) in the United States. The document provides background on the definition and treatment of cataracts and…

  16. Mental Health and the Elderly: Issues in Service Delivery to the American Indian and the Hispanic Communities. Part II. Hearing before the Select Committee on Aging. House of Representatives, One Hundredth Congress, Second Session (Denver, Colorado).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This field hearing by the House Select Committee on Aging produced testimony on the mental health problems and service delivery needs of American Indian and Hispanic American elderly. A director of research and two American Indian advocates: (1) pointed out the high rate of depression among Indian elderly due to physical impairments and deprived…

  17. Our Greatest Generation: Continuing a Lifetime of Service. Hearing before the Special Committee on Aging. United States Senate, One Hundred Seventh Congress, First Session (Indianapolis, Indiana, August 9, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This Congressional report contains the remarks made at a special meeting of the United States Committee on Aging to celebrate senior citizen's service to their community and examine policies regarding federally funded senior service programs. The following are among the programs, agencies, and organizations represented: Senior Companion Program;…

  18. Voluntarism in America: Promoting Individual and Corporate Responsibility. Hearing before the Subcommittee on Aging, Family and Human Services of the Committee on Labor and Human Resources, United States Senate, Ninety-Seventh Congress, Second Session (April 22, 1982).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This is a report of a hearing held in Washington, D.C., on April 22, 1982, before the Subcommittee on Aging, Family, and Human Services of the Committee on Labor and Human Resources, United States Senate. The purpose of the hearing was to examine the untapped human potentials for volunteerism in America by promoting individual and corporate…

  19. Improving Legal Representation for Older Americans. Hearing Before the Special Committee on Aging, United States Senate, Ninety-Fourth Congress, Second Session. Part 2--Boston, Mass., August 30, 1976.

    ERIC Educational Resources Information Center

    1977

    The minutes of the meeting of the Special Committee on Aging of the U.S. Senate on the issue of legal services programs for the elderly, specifically programs in effect in the Boston area include statements made by the following: (1) an elderly diabetic woman testifying about living conditions and lack of services in her housing project; (2) the…

  20. 75 FR 11188 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Beeson Meeting. Date: April 28-29, 2010. Time..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  1. 77 FR 31032 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Network Infrastructure Support. Date: June 7...., Scientific Review Officer, Scientific Review Branch, National Institute on Aging, Gateway Bldg., 2C212,...

  2. 76 FR 57064 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, AD Genetics Warehouse. Date: October 7, 2011..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  3. Thyroid Function in Small for Gestational Age Newborns: A Review

    PubMed Central

    Bagnoli, Franco; Laura, Farmeschi; Sara, Nappini; Salvatore, Grosso

    2013-01-01

    Several studies have shown that small for gestational age (SGA) babies have a different hormonal profile than those born with a birth weight appropriate for gestational age (AGA). Thyroid hormones play an important role in growth and neurocognitive development. Only few studies analyzed the concentrations of thyroid-stimulating hormone (TSH) and thyroxine (T4) during fetal and extrauterine life in SGA and AGA newborns, and the existing data on the possible alterations of these hormones in postnatal life are controversial. It remains to be established whether SGA newborns have different blood concentrations of thyroid hormones as compared with AGA infants and if so, whether these findings play a role in the development of obesity, short stature, hypertension, and diabetes - disorders, already known to be related with SGA birth. It has also not yet been established whether and when substitutive therapy with levothyroxine (LT4) should be initiated in preterm and full-term SGA newborns. Further trials are needed to determine the thyroid hormone profile in both preterm and full-term SGA newborns and also to evaluate the effectiveness and safety of LT4 treatment in these infants. Conflict of interest:None declared. PMID:23149390

  4. Thyroid function in small for gestational age newborns: a review.

    PubMed

    Franco, Bagnoli; Laura, Farmeschi; Sara, Nappini; Salvatore, Grosso

    2013-01-01

    Several studies have shown that small for gestational age (SGA) babies have a different hormonal profile than those born with a birth weight appropriate for gestational age (AGA). Thyroid hormones play an important role in growth and neurocognitive development. Only few studies analyzed the concentrations of thyroid-stimulating hormone (TSH) and thyroxine (T4) during fetal and extrauterine life in SGA and AGA newborns, and the existing data on the possible alterations of these hormones in postnatal life are controversial. It remains to be established whether SGA newborns have different blood concentrations of thyroid hormones as compared with AGA infants and if so, whether these findings play a role in the development of obesity, short stature, hypertension, and diabetes--disorders, already known to be related with SGA birth. It has also not yet been established whether and when substitutive therapy with levothyroxine (LT4) should be initiated in preterm and full-term SGA newborns. Further trials are needed to determine the thyroid hormone profile in both preterm and full-term SGA newborns and also to evaluate the effectiveness and safety of LT4 treatment in these infants.

  5. Spondyloarthropathy presenting at a young age: case report and review.

    PubMed

    Hartman, Golda H; Renaud, Deborah L; Sundaram, Murali; Reed, Ann M

    2007-02-01

    The diagnosis of juvenile spondyloarthritis (JSA) is rarely entertained in young children who present with back and leg pain. We present a case of a 6-year-old male who presented with a 3-year history of severe back and leg pain and a positive Gower's sign, and was given a presumed diagnosis of muscular dystrophy. Presenting serologic evaluation included a mildly elevated sedimentation rate and C-reactive protein (CRP). Computed tomography of the pelvis demonstrated large erosions affecting both sacro-iliac joints. Despite the unusually young age of this patient, ankylosing spondylitis seemed the most plausible diagnosis. Following rheumatological evaluation and treatment for JSA, he showed significant clinical improvement. His disease, however, has not entirely remitted with signs of enthesitis at the Achilles tendon and knees. We present this case to illustrate that JSA could account for symptoms at an early age and not considering it could lead to multiple medical visits and diagnoses. To our knowledge, based on a search of the World literature, this would appear to be the youngest case of JSA reported with demonstrable severe sacroiliitis.

  6. Protecting the Elderly: Federal Agencies' Role concerning Questionable Marketing Practices. Fact Sheet for the Chairman, Select Committee on Aging, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of Human Resources.

    In response to Representative Edward Roybal's concern that aging organizations have used direct mail in a manner that might frighten, threaten, or coerce the elderly into contributing money or buying products from these organizations, the General Accounting Office (GAO) agreed to: (1) identify federal agencies with jurisdiction in reviewing the…

  7. Fusion Energy Sciences Advisory Committee Reports on Review of the Fusion Materials Research Program, Review of the Proposed Proof-of-Principle Programs, Review of the Possible Pathways for Pursuing Burning Plasma Physics, and Comments on the ER Facilities Roadmap

    SciTech Connect

    none,

    1998-07-01

    The Fusion Energy Science Advisory Committee was asked to conduct a review of Fusion Materials Research Program (the Structural Materials portion of the Fusion Program) by Dr. Martha Krebs, Director of Energy Research for the Department of Energy. This request was motivated by the fact that significant changes have been made in the overall direction of the Fusion Program from one primarily focused on the milestones necessary to the construction of successively larger machines to one where the necessary scientific basis for an attractive fusion energy system is. better understood. It was in this context that the review of current scientific excellence and recommendations for future goals and balance within the Program was requested.

  8. Attachment theory, ageing and dementia: a review of the literature.

    PubMed

    Browne, C J; Shlosberg, E

    2006-03-01

    The following review draws together recent theoretical contributions and research findings highlighting the pertinence of attachment issues for older adults. Beginning with a brief overview of the principles of attachment theory, the paper proceeds to illustrate that attachment remains a key feature of relationships throughout the life cycle. Research findings suggest that past and present secure attachment relationships function as a protective resource in later life and preliminary studies highlight the continuing salience of parents as attachment figures for older adults. Particular attention is given to the significance of attachment theory in thinking about the subjective experiences of people with dementia, for whom unwilling separation and disruption of attachment bonds can be common themes. Research indicates the frequent occurrence of attachment behaviours and parent fixation amongst people with dementia living in residential care. Pre-morbid attachment style has been shown to interact with emotional and behavioural expression during the course of dementia. Clinical applications of attachment theory in dementia care are discussed and initial evidence for the effectiveness of Simulated Presence Therapy is provided. Methodological issues raised by the review are considered, together with suggestions for future research.

  9. The Physical Activity Levels of Preschool-Aged Children: A Systematic Review

    ERIC Educational Resources Information Center

    Tucker, Patricia

    2008-01-01

    This systematic review presents research on the physical activity levels of preschool-aged children (aged 2-6 years). Thirty-nine primary studies (published 1986-2007) representing a total of 10,316 participants (5236 male and 5080 female), from seven countries are described and the physical activity behaviors of this population are considered in…

  10. A Narrative Review of Problem-Based Learning with School-Aged Children: Implementation and Outcomes

    ERIC Educational Resources Information Center

    Jerzembek, Gabi; Murphy, Simon

    2013-01-01

    This paper reviews empirical studies that have evaluated the impact of problem-based learning (PBL) on school-aged pupils, in order to summarise how it has been implemented and to assess its effects on academic and personal development. Following electronic searches of PsychINFO, the British Education Index and the Cochrane review database, six…

  11. Anchoring contextual analysis in health policy and systems research: A narrative review of contextual factors influencing health committees in low and middle income countries.

    PubMed

    George, Asha; Scott, Kerry; Garimella, Surekha; Mondal, Shinjini; Ved, Rajani; Sheikh, Kabir

    2015-05-01

    Health committees, councils or boards (HCs) mediate between communities and health services in many health systems. Despite their widespread prevalence, HC functions vary due to their diversity and complexity, not least because of their context specific nature. We undertook a narrative review to better understand the contextual features relevant to HCs, drawing from Scopus and the internet. We found 390 English language articles from journals and grey literature since 1996 on health committees, councils and boards. After screening with inclusion and exclusion criteria, we focused on 44 articles. Through an iterative process of exploring previous attempts at understanding context in health policy and systems research (HPSR) and the HC literature, we developed a conceptual framework that delineates these contextual factors into four overlapping spheres (community, health facilities, health administration, society) with cross-cutting issues (awareness, trust, benefits, resources, legal mandates, capacity-building, the role of political parties, non-governmental organizations, markets, media, social movements and inequalities). While many attempts at describing context in HPSR result in empty arenas, generic lists or amorphous detail, we suggest anchoring an understanding of context to a conceptual framework specific to the phenomena of interest. By doing so, our review distinguishes between contextual elements that are relatively well understood and those that are not. In addition, our review found that contextual elements are dynamic and porous in nature, influencing HCs but also being influenced by them due to the permeability of HCs. While reforms focus on tangible HC inputs and outputs (training, guidelines, number of meetings held), our review of contextual factors highlights the dynamic relationships and broader structural elements that facilitate and/or hinder the role of health committees in health systems. Such an understanding of context points to its

  12. Anchoring contextual analysis in health policy and systems research: A narrative review of contextual factors influencing health committees in low and middle income countries.

    PubMed

    George, Asha; Scott, Kerry; Garimella, Surekha; Mondal, Shinjini; Ved, Rajani; Sheikh, Kabir

    2015-05-01

    Health committees, councils or boards (HCs) mediate between communities and health services in many health systems. Despite their widespread prevalence, HC functions vary due to their diversity and complexity, not least because of their context specific nature. We undertook a narrative review to better understand the contextual features relevant to HCs, drawing from Scopus and the internet. We found 390 English language articles from journals and grey literature since 1996 on health committees, councils and boards. After screening with inclusion and exclusion criteria, we focused on 44 articles. Through an iterative process of exploring previous attempts at understanding context in health policy and systems research (HPSR) and the HC literature, we developed a conceptual framework that delineates these contextual factors into four overlapping spheres (community, health facilities, health administration, society) with cross-cutting issues (awareness, trust, benefits, resources, legal mandates, capacity-building, the role of political parties, non-governmental organizations, markets, media, social movements and inequalities). While many attempts at describing context in HPSR result in empty arenas, generic lists or amorphous detail, we suggest anchoring an understanding of context to a conceptual framework specific to the phenomena of interest. By doing so, our review distinguishes between contextual elements that are relatively well understood and those that are not. In addition, our review found that contextual elements are dynamic and porous in nature, influencing HCs but also being influenced by them due to the permeability of HCs. While reforms focus on tangible HC inputs and outputs (training, guidelines, number of meetings held), our review of contextual factors highlights the dynamic relationships and broader structural elements that facilitate and/or hinder the role of health committees in health systems. Such an understanding of context points to its

  13. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in adults aged 65 years and older - Advisory Committee on Immunization Practices (ACIP), 2012.

    PubMed

    2012-06-29

    Since 2005, the Advisory Committee on Immunization Practices (ACIP) has recommended a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine booster dose for all adolescents aged 11 through 18 years (preferred at 11 through 12 years) and for those adults aged 19 through 64 years who have not yet received a dose. In October 2010, despite the lack of an approved Tdap vaccine for adults aged 65 years and older, ACIP recommended that unvaccinated adults aged 65 years and older be vaccinated with Tdap if in close contact with an infant, and that other adults aged 65 years and older may receive Tdap. In July 2011, the Food and Drug Administration (FDA) approved expanding the age indication for Boostrix (GlaxoSmithKline Biologicals, Rixensart, Belgium) to aged 65 years and older. In February 2012, ACIP recommended Tdap for all adults aged 65 years and older. This recommendation supersedes previous Tdap recommendations regarding adults aged 65 years and older.

  14. 76 FR 30374 - National Institute on Aging; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Meetings Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Member Conflict Sep. Date: June 2..., PhD, Chief, Scientific Review Branch, National Institute on Aging, National Institutes of...

  15. 75 FR 54160 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Committee: National Institute on Aging Special Emphasis Panel; Menopause and Sleep Disorders. Date: October... Effects of Early Education. Date: October 22, 2010. Time: 10 a.m. to 1 p.m. Agenda: To review and...

  16. 78 FR 66369 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ..., Bethesda, MD 20814, which was published in the Federal Register on August 23, 2013, 52552 FR 164. Meeting... Notice is hereby given of a change in the meeting of the Neuroscience of Aging Review Committee,...

  17. SPR Awards Committee

    NASA Astrophysics Data System (ADS)

    Tsurutani, Bruce T.

    The SPR Awards Committee has been formed for the next 2-year period (July 1, 1990-June 30, 1992). It consists of Marty Lee (chair), University of New Hampshire, tel. 603-862-3509; Nancy Crooker (ex-officio), University of California at Los Angeles; Bill Kurth, University of Iowa; Tom Moore, Marshall Space Flight Center; Ed Roelof, Johns Hopkins University, Applied Physics Laboratory; Bob Schunk, Utah State University; and Dan Winske, Los Alamos National Laboratory.The SPR Awards Committee has several responsibilities, including solicitation and development of proposals for potential AGU Fellows from the SPR section; the AGU Fellows Committee makes the final selections. The awards committee also reviews SPR student papers at the Fall and Spring AGU Meetings and nominates outstanding papers for AGU recognition.

  18. 76 FR 24894 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... 6214, MSC 7804, Bethesda, MD 20892, (301) 408-9512, gubanics@csr.nih.gov . Name of Committee: Cell Biology Integrated Review Group; Cellular Mechanisms in Aging and Development Study Section. Date: June 13....hhs.gov . Name of Committee: Oncology 1--Basic Translational Integrated Review Group;...

  19. 78 FR 69991 - Advisory Committee; Veterinary Medicine Advisory Committee; Termination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... established on April 24, 1984 (49 FR 20809; May 17, 1984). The purpose of the Committee was to review and... HUMAN SERVICES Food and Drug Administration 21 CFR Part 14 Advisory Committee; Veterinary Medicine... Food and Drug Administration (FDA) is announcing the termination of the Veterinary Medicine...

  20. Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review.

    PubMed

    Velarde, Michael C; Demaria, Marco

    2016-01-01

    Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during aging, including the skin. Senescent cells secrete proinflammatory cytokines, chemokines, growth factors, and proteases, a phenomenon called senescence-associated secretory phenotype (SASP), which are thought to contribute to the functional decline of the skin as a consequence of aging. Due to the potential negative effects of the SASP in aged organisms, drugs that selectively target senescent cells represent an intriguing therapeutic strategy to delay aging and age-related diseases. Here, we review studies on the role of senescent cells in the skin, with particular emphasis on the age-related mechanisms and phenotypes associated with excessive accumulation of cellular senescence. We discuss the aberrant behavior of senescent cells in aging and how the different signaling pathways associated with survival and secretion of senescent cells can be engaged for the development of targeted therapies.

  1. Environment as 'Brain Training': A review of geographical and physical environmental influences on cognitive ageing.

    PubMed

    Cassarino, Marica; Setti, Annalisa

    2015-09-01

    Global ageing demographics coupled with increased urbanisation pose major challenges to the provision of optimal living environments for older persons, particularly in relation to cognitive health. Although animal studies emphasize the benefits of enriched environments for cognition, and brain training interventions have shown that maintaining or improving cognitive vitality in older age is possible, our knowledge of the characteristics of our physical environment which are protective for cognitive ageing is lacking. The present review analyses different environmental characteristics (e.g. urban vs. rural settings, presence of green) in relation to cognitive performance in ageing. Studies of direct and indirect associations between physical environment and cognitive performance are reviewed in order to describe the evidence that our living contexts constitute a measurable factor in determining cognitive ageing.

  2. Early age of onset in fatal familial insomnia. Two novel cases and review of the literature.

    PubMed

    Harder, A; Gregor, A; Wirth, T; Kreuz, F; Schulz-Schaeffer, W J; Windl, O; Plotkin, M; Amthauer, H; Neukirch, K; Kretzschmar, H A; Kuhlmann, T; Braas, R; Hahne, H H; Jendroska, K

    2004-06-01

    Fatal familial insomnia (FFI) is a prion disease exhibiting the PRNP D178N/129M genotype. Features of this autosomal dominant illness are progressive insomnia, dysautonomia, myoclonus, cognitive decline and motor signs associated with thalamic nerve cell loss and gliosis. In contrast to the new variant of Creutzfeldt-Jakob disease (vCJD) the onset of FFI is in middle to late adulthood. We report two male patients who belong to a large German FFI kindred. They were examined clinically, and postmortem neuropathological examination was carried out in collaboration with the German reference centre for prion disease. Additionally, the prion protein gene (PRNP) was analysed. To identify further patients with disease onset under 30 years of age a comprehensive literature review was carried out. Two male patients presented with typical symptoms of FFI at the age of 23 and 24 years. In their kindred, the age of onset has never before been under 44 years of age. Our literature review identified five additional early onset cases who died at age 21 to 25 years. In all 22 reviewed FFI families the median manifestation age was 49.5 years. Although phenotypic variability of FFI is common, age of onset under 30 years has been considered to be a hallmark of vCJD with a mean manifestation at 27 years of age. Our findings underline that in addition to vCJD, FFI must be considered in cases of young-onset prion disease. This has considerable impact on clinical management and genetic counselling.

  3. Scientific and Regulatory Policy Committee Review: Review of the Organisation for Economic Co-operation and Development (OECD) Guidance on the GLP Requirements for Peer Review of Histopathology.

    PubMed

    Fikes, James D; Patrick, Daniel J; Francke, Sabine; Frazier, Kendall S; Reindel, James F; Romeike, Annette; Spaet, Robert H; Tomlinson, Lindsay; Schafer, Kenneth A

    2015-10-01

    In 2014, the Organisation for Economic Co-operation and Development (OECD) issued guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The stated purpose of the guidance document is "to provide guidance to pathologists, test facility management, study directors and quality assurance personnel on how the peer review of histopathology should be planned, managed, documented, and reported in order to meet Good Laboratory Practice (GLP) expectations and requirements." On behalf of and in collaboration with the global societies of toxicologic pathology, the Society of Toxicologic Pathology initiated a review of OECD guidance no. 16. The objectives of this review are to provide a unified interpretation of the guidance, to recommend compliant processes for organizations to implement, and to avoid inconsistent process adaptations across the industry. This review of the guidance document is the product of a global collaboration with other societies of toxicologic pathology and provides a section-by-section international consensus view and interpretation of the OECD guidance on peer review.

  4. Effect of advanced glycation end product intake on inflammation and aging: a systematic review.

    PubMed

    Van Puyvelde, Katrien; Mets, Tony; Njemini, Rose; Beyer, Ingo; Bautmans, Ivan

    2014-10-01

    Aging is associated with a chronic low-grade inflammatory status that contributes to chronic diseases such as age-related muscle wasting, kidney disease, and diabetes mellitus. Since advanced glycation end products (AGEs) are known to be proinflammatory, this systematic review examined the relation between the dietary intake of AGEs and inflammatory processes. The PubMed and Web of Science databases were screened systematically. Seventeen relevant studies in humans or animals were included. The intervention studies in humans showed mainly a decrease in inflammation in subjects on a low-AGE diet, while an increase in inflammation in subjects on a high-AGE diet was less apparent. About half of the observational studies found a relationship between inflammatory processes and AGEs in food. When the results are considered together, the dietary intake of AGEs appears to be related to inflammatory status and the level of circulating AGEs. Moreover, limiting AGE intake may lead to a decrease in inflammation and chronic diseases related to inflammatory status. Most of the trials were conducted in patients with chronic kidney disease or diabetes, and thus additional studies in healthy individuals are needed. Further investigation is needed to elucidate the effects of lifetime exposure of dietary AGEs on aging and health.

  5. 36 CFR 1151.6 - Committees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and consider recommendations and proposals from the various subject matter committees; (ii) To review..., the chairs of each of the subject matter committees, and two at large members. The two at large... election of the Chair and Vice-Chair of the Board and the chairs of the subject matter committees. In...

  6. 36 CFR 1151.6 - Committees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and consider recommendations and proposals from the various subject matter committees; (ii) To review..., the chairs of each of the subject matter committees, and two at large members. The two at large... election of the Chair and Vice-Chair of the Board and the chairs of the subject matter committees. In...

  7. 36 CFR 1151.6 - Committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and consider recommendations and proposals from the various subject matter committees; (ii) To review..., the chairs of each of the subject matter committees, and two at large members. The two at large... election of the Chair and Vice-Chair of the Board and the chairs of the subject matter committees. In...

  8. Advisory Committee: Dr. Jekyll or Mr. Hyde?

    ERIC Educational Resources Information Center

    Rippey, Donald T.; Vickers, Mozell

    1978-01-01

    Reasons for the underutilization or misuse and the effectiveness or ineffectiveness of advisory committees in community college vocational programs are reviewed and discussed from the experience of community college administrators. The article also notes the duties of local advisory committees and how committees can be involved in college…

  9. Concise review: the epigenetic contribution to stem cell ageing: can we rejuvenate our older cells?

    PubMed

    Armstrong, Lyle; Al-Aama, Jumana; Stojkovic, Miodrag; Lako, Majlinda

    2014-09-01

    Although certainly one of the most recognizable characteristics of human biology, aging remains one of the least understood. This is largely attributable to the fact that aging is both gradual and inherently complex, with almost all aspects of physiology and phenotype undergoing steady modification with advancing age. The complexity of the aging process does not allow for a single all-encompassing definition, yet decades of study using diverse systems, methodologies, and model organisms have begun to build a consensus regarding the central physiological characteristics of aging. Indeed, such studies have shown that the process of aging is invariably accompanied by a diminished capacity to adequately maintain tissue homeostasis or to repair tissues after injury. When homeostatic control diminishes to the point at which tissue/organ integrity and function are no longer sufficiently maintained, physiologic decline ensues, and aging is manifested. Inadequate organ homeostasis indicates possible dysfunction of tissue-specific stem cells. Several mechanisms have been postulated to account for age-related cellular changes; however, increasing literature evidence suggests that age-related changes to the epigenome make a major contribution to the aged phenotype. In this review, we discuss the evidence for epigenetic contributions to tissue-specific stem cell ageing. PMID:24740867

  10. Mini-review: Retarding aging in murine genetic models of neurodegeneration.

    PubMed

    Albin, Roger L; Miller, Richard A

    2016-01-01

    Retardation of aging processes is a plausible approach to delaying the onset or slowing the progression of common neurodegenerative disorders. We review the results of experiments using murine genetic models of Alzheimer disease and Huntington disease to evaluate the effects of retarding aging. While positive results are reported in several of these experiments, there are several discrepancies in behavioral and pathologic outcomes both within and between different experiments. Similarly, different experiments yield varying assessments of potential proximate mechanisms of action of retarding aging. The anti-aging interventions used for some experiments include some that show only modest effects on lifespan, and others that have proven hard to reproduce. Several experiments used aggressive transgenic neurodegenerative disease models that may be less relevant in the context of age-related diseases. The experience with these models and interventions may be useful in designing future experiments assessing anti-aging interventions for disease-modifying treatment of neurodegenerative diseases.

  11. Age-Related Changes in Performance and Recovery Kinetics in Masters Athletes: A Narrative Review.

    PubMed

    Borges, Nattai; Reaburn, Peter; Driller, Matthew; Argus, Christos

    2016-01-01

    Despite increasing participation rates in masters sport and extensive research examining age-related changes in performance, little is known about the effect of age on recovery kinetics in masters athletes. This narrative review focuses on the relationship between aging and sport participation, and the effect on both performance and recovery following an exercise bout. Current research suggests the effect of age on performance and recovery may be smaller than originally suggested and that increasing sedentary lifestyles appear to play a larger role in any observed decrements in performance and recovery in masters athletes. Currently, it appears that performance decrements are inevitable with age. However, performance capacities can be maintained through systematic physical training. Moreover, the limited current research suggests there may be an age effect on recovery kinetics following an exercise bout, although further research is required to understand the acute and chronic recovery processes in the masters athlete.

  12. Leadership in Literacy for the Information Age. A Report of the Committee on Instructional Technology, National Council of Teachers of English. Executive Summary.

    ERIC Educational Resources Information Center

    Oates, William R., Ed.

    Responding to concerns of the National Council of Teachers of English (NCTE) Task Force on Excellence in Education that current uses of computers in teaching English language arts may undercut rather than advance excellence, this report, prepared by the NCTE Committee on Instructional Technology, summarizes the committee's thoughts and…

  13. Chemical-biological terrorism and its impact on children: a subject review. American Academy of Pediatrics. Committee on Environmental Health and Committee on Infectious Diseases.

    PubMed

    2000-03-01

    There is an increasing threat that chemical and biological weapons will be used on a civilian population in an act of domestic terrorism. Casualties among adults and children could be significant in such an event. Federal, state, and local authorities have begun extensive planning to meet a chemical-biological incident by developing methods of rapid identification of potential agents and protocols for management of victims without injury to health care personnel. Because children would be disproportionately affected by a chemical or biological weapons release, pediatricians must assist in planning for a domestic chemical-biological incident. Government agencies should seek input from pediatricians and pediatric subspecialists to ensure that the situations created by multiple pediatric casualties after a chemical-biological incident are considered. This statement reviews key aspects of chemical-biological agents, the consequences of their use, the potential impact of a chemical-biological attack on children, and issues to consider in disaster planning and management for pediatric patients.

  14. Age- and stroke-related skeletal muscle changes: a review for the geriatric clinician.

    PubMed

    Sions, Jaclyn Megan; Tyrell, Christine M; Knarr, Brian A; Jancosko, Angela; Binder-Macleod, Stuart A

    2012-01-01

    Independently, aging and stroke each have a significant negative impact on skeletal muscle, but the potential cumulative effects of aging and stroke have not been explored. Optimal interventions for individuals post stroke may include those that specifically target skeletal muscle. Addressing changes in muscles may minimize activity limitations and enhance participation post stroke. This article reviews the impact of aging and stroke on muscle morphology and composition, including fiber atrophy, reductions in muscle cross-sectional area, changes in muscle fiber distributions, and increases in intramuscular fat. Relationships between changes in muscle structure, muscle function, and physical mobility are reviewed. Clinical recommendations that preserve and enhance skeletal muscle in the aging adult and individuals post stroke are discussed. Future research directions that include systematic comparison of the differences in skeletal muscle between younger and older adults who have sustained a stroke are suggested.

  15. 75 FR 36698 - Committee Management Renewals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ..., 1115 Advisory Committee for GPRA Performance Assessment, 13853 Advisory Committee for Mathematical and... Communications and Cyber Systems, 1196 Proposal Review Panel for Engineering Education and Centers, 173 Proposal... Graduate Education, 57 Proposal Review Panel for Human Resource Development, 1199 Proposal Review Panel...

  16. Causes of dysphagia among different age groups: a systematic review of the literature.

    PubMed

    Roden, Dylan F; Altman, Kenneth W

    2013-12-01

    Dysphagia is a common problem that has the potential to result in severe complications such as malnutrition and aspiration pneumonia. Based on the complexity of swallowing, there may be many different causes. This article presents a systematic literature review to assess different comorbid disease associations with dysphagia based on age. The causes of dysphagia are different depending on age, affecting between 1.7% and 11.3% of the general population. Dysphagia can be a symptom representing disorders pertinent to any specialty of medicine. This review can be used to aid in the diagnosis of patients presenting with the complaint of dysphagia.

  17. 14 CFR 129.105 - Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aging airplane inspections and records... § 129.105 Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft. (a... completed the aging airplane inspection and records review required by this section. During the...

  18. 14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aging airplane inspections and records... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine... aging airplane inspection and records review required by this section. During the inspection and...

  19. 14 CFR 129.105 - Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aging airplane inspections and records... § 129.105 Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft. (a... completed the aging airplane inspection and records review required by this section. During the...

  20. 14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aging airplane inspections and records... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine... aging airplane inspection and records review required by this section. During the inspection and...

  1. 14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aging airplane inspections and records... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine... aging airplane inspection and records review required by this section. During the inspection and...

  2. 14 CFR 129.105 - Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aging airplane inspections and records... § 129.105 Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft. (a... completed the aging airplane inspection and records review required by this section. During the...

  3. 14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aging airplane inspections and records... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine... aging airplane inspection and records review required by this section. During the inspection and...

  4. 14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aging airplane inspections and records... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine... aging airplane inspection and records review required by this section. During the inspection and...

  5. 14 CFR 129.105 - Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aging airplane inspections and records... § 129.105 Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft. (a... completed the aging airplane inspection and records review required by this section. During the...

  6. 14 CFR 129.105 - Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aging airplane inspections and records... § 129.105 Aging airplane inspections and records reviews for U.S.-registered multiengine aircraft. (a... completed the aging airplane inspection and records review required by this section. During the...

  7. Chemical-biological terrorism and its impact on children: a subject review. American Academy of Pediatrics. Committee on Environmental Health and Committee on Infectious Diseases.

    PubMed

    2000-03-01

    There is an increasing threat that chemical and biological weapons will be used on a civilian population in an act of domestic terrorism. Casualties among adults and children could be significant in such an event. Federal, state, and local authorities have begun extensive planning to meet a chemical-biological incident by developing methods of rapid identification of potential agents and protocols for management of victims without injury to health care personnel. Because children would be disproportionately affected by a chemical or biological weapons release, pediatricians must assist in planning for a domestic chemical-biological incident. Government agencies should seek input from pediatricians and pediatric subspecialists to ensure that the situations created by multiple pediatric casualties after a chemical-biological incident are considered. This statement reviews key aspects of chemical-biological agents, the consequences of their use, the potential impact of a chemical-biological attack on children, and issues to consider in disaster planning and management for pediatric patients. PMID:10699130

  8. The potential effects of meditation on age-related cognitive decline: a systematic review.

    PubMed

    Gard, Tim; Hölzel, Britta K; Lazar, Sara W

    2014-01-01

    With a rapidly aging society it becomes increasingly important to counter normal age-related decline in cognitive functioning. Growing evidence suggests that cognitive training programs may have the potential to counteract this decline. On the basis of a growing body of research that shows that meditation has positive effects on cognition in younger and middle-aged adults, meditation may be able to offset normal age-related cognitive decline or even enhance cognitive function in older adults. In this paper, we review studies investigating the effects of meditation on age-related cognitive decline. We searched the Web of Science (1900 to present), PsycINFO (1597 to present), MEDLINE (1950 to present), and CABI (1910 to present) to identify original studies investigating the effects of meditation on cognition and cognitive decline in the context of aging. Twelve studies were included in the review, six of which were randomized controlled trials. Studies involved a wide variety of meditation techniques and reported preliminary positive effects on attention, memory, executive function, processing speed, and general cognition. However, most studies had a high risk of bias and small sample sizes. Reported dropout rates were low and compliance rates high. We conclude that meditation interventions for older adults are feasible, and preliminary evidence suggests that meditation can offset age-related cognitive decline.

  9. The potential effects of meditation on age-related cognitive decline: a systematic review

    PubMed Central

    Gard, Tim; Hölzel, Britta K.; Lazar, Sara W.

    2014-01-01

    With a rapidly aging society it becomes increasingly important to counter normal age-related decline in cognitive functioning. Growing evidence suggests that cognitive training programs may have the potential to counteract this decline. On the basis of a growing body of research that shows that meditation has positive effects on cognition in younger and middle-aged adults, meditation may be able to offset normal age-related cognitive decline or even enhance cognitive function in older adults. In this paper, we review studies investigating the effects of meditation on age-related cognitive decline. We searched the Web of Science (1900 to present), PsycINFO (1597 to present), MEDLINE (1950 to present), and CABI (1910 to present) to identify original studies investigating the effects of meditation on cognition and cognitive decline in the context of aging. Twelve studies were included in the review, six of which were randomized controlled trials. Studies involved a wide variety of meditation techniques and reported preliminary positive effects on attention, memory, executive function, processing speed, and general cognition. However, most studies had a high risk of bias and small sample sizes. Reported dropout rates were low and compliance rates high. We conclude that meditation interventions for older adults are feasible, and preliminary evidence suggests that meditation can offset age-related cognitive decline. PMID:24571182

  10. Exercise training as a preventive tool for age-related disorders: a brief review

    PubMed Central

    Ciolac, Emmanuel Gomes

    2013-01-01

    Aging populations are a worldwide phenomenon affecting both developed and developing countries. This issue raises serious concerns for both governments and the general population. Regular participation in physical activity and/or exercise training programs can minimize the physiological alterations that occur during aging and may contribute to improvements in health and well-being. The present review will discuss the role of regular exercise training in preventing age-related physiological decline and, consequently, associated chronic diseases. Compelling evidence that regular exercise and/or physical activity can improve quality of life, prevent or control the development of chronic disease and increase life expectancy is shown. In summary, regular exercise training and/or physical activity has an important influence on aging and may help to prevent age-related disorders. PMID:23778419

  11. Human neuromuscular structure and function in old age: A brief review

    PubMed Central

    Power, Geoffrey A.; Dalton, Brian H.; Rice, Charles L.

    2016-01-01

    Natural adult aging is associated with many functional impairments of the human neuromuscular system. One of the more observable alterations is the loss of contractile muscle mass, termed sarcopenia. The loss of muscle mass occurs primarily due to a progressive loss of viable motor units, and accompanying atrophy of remaining muscle fibers. Not only does the loss of muscle mass contribute to impaired function in old age, but alterations in fiber type and myosin heavy chain isoform expression also contribute to weaker, slower, and less powerful contracting muscles. This review will focus on motor unit loss associated with natural adult aging, age-related fatigability, and the age-related differences in strength across contractile muscle actions. PMID:27011872

  12. Ethics committees in France.

    PubMed

    Isambert, F A

    1989-08-01

    Leading biologists and physicians in France have been considering bioethical problems for several decades. In 1983 an important new forum for bioethical discussion in France was created, with the establishment of the Comité Consultatif National d'Ethique pour les Sciences de la Vie et de la Santé (C.C.N.E.). This committee has produced numerous important opinions and reports on such topics as research involving human subjects, fetal tissue research, and the new reproductive technologies. At the local level the discussion of bioethical questions is carried on by ethics committees, which are charged with the responsibility of reviewing research protocols.

  13. A systematic review on zinc for the prevention and treatment of age-related macular degeneration

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Zinc is a potential candidate for the prevention and treatment of age-related macular degeneration (AMD) due to its high concentration in the retina and role as a cofactor for antioxidant enzymes. The objective of this work was to conduct a systematic review of studies that investigated dietary inta...

  14. A Review and New Look at Ethical Suicide in Advanced Age.

    ERIC Educational Resources Information Center

    Carpenter, Brian D.

    1993-01-01

    Notes that suicide is common in old age, but public opinion remains negative. Following a review of theories of suicide and summary of arguments against suicide, constructs argument for why elderly have unique claim to an ethical, unobstructed suicide. Claim rests on their "developmental autonomy," based on experience and wisdom of the elderly.…

  15. Cost-Effectiveness of Social Work Services in Aging: An Updated Systematic Review

    ERIC Educational Resources Information Center

    Rizzo, Victoria M.; Rowe, Jeannine M.

    2016-01-01

    Objectives: This study examines the impact of social work interventions in aging on quality of life (QOL) and cost outcomes in four categories (health, mental health, geriatric evaluation and management, and caregiving). Methods: Systematic review methods are employed. Databases were searched for articles published in English between 2004 and 2012…

  16. Explaining Differences in Age at Autism Spectrum Disorder Diagnosis: A Critical Review

    ERIC Educational Resources Information Center

    Daniels, Amy M.; Mandell, David S.

    2014-01-01

    The diagnosis of autism is often delayed, which translates into a missed opportunity to provide treatment during a critical developmental period. This study reviews studies that assessed factors associated with age at autism spectrum disorder diagnosis and provides recommendations on future research, programs, and policies to improve early…

  17. A Systematic Review of Common Physiotherapy Interventions in School-Aged Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Martin, Liz; Baker, Richard; Harvey, Adrienne

    2010-01-01

    This systematic review focused on the common conventional physiotherapy interventions used with children with cerebral palsy (CP), aged 4 to 18 years, and critically appraised the recent evidence of each of these interventions using the Oxford Centre for Evidence-Based Medicine Levels of Evidence. The search strategy yielded 34 articles after…

  18. Age at Weaning and Infant Growth: Primary Analysis and Systematic Review

    PubMed Central

    Vail, Brennan; Prentice, Philippa; Dunger, David B.; Hughes, Ieuan A.; Acerini, Carlo L.; Ong, Ken K.

    2015-01-01

    Objective To test whether earlier age at weaning (age 3-6 months) may promote faster growth during infancy. Study design Weaning at age 3.0-7.0 months was reported by 571 mothers of term singletons in a prospective birth cohort study conducted in Cambridge, UK. Infant weight and length were measured at birth and at age 3 months and 12 months. Anthropometric values were transformed into age- and sex-adjusted z-scores. Three linear regression models were performed, including adjustment for confounders in a stepwise manner. Measurements at age 3 months, before weaning, were used to consider reverse causality. Results Almost three-quarters (72.9%) of infants were weaned before age 6 months. Age at weaning of 3.0-7.0 months was inversely associated with weight and length (but not with body mass index) at 12 months (both P ≤ .01, adjusted for maternal and demographic factors). These associations were attenuated after adjustment for type of milk feeding and weight or length at age 3 months (before weaning). Rapid weight gain between 0 and 3 months predicted subsequent earlier age at weaning (P = .01). Our systematic review identified 2 trials, both reporting null effects of age at weaning on growth, and 15 observational studies, with 10 reporting an inverse association between age at weaning and infant growth and 4 reporting evidence of reverse causality. Conclusion In high-income countries, weaning between 3 and 6 months appears to have a neutral effect on infant growth. Inverse associations are likely related to reverse causality. PMID:26073105

  19. 75 FR 26710 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Committee (Dairy Committee) for two days to discuss farm milk price volatility and dairy farmer... the Dairy Committee. The Dairy Committee will review the issues of farm milk price volatility and..., DC 20250 The purpose of the meeting is to: Discuss farm milk price volatility and dairy...

  20. Review of performance, medical, and operational data on pilot aging issues

    NASA Technical Reports Server (NTRS)

    Stoklosa, J. H.

    1992-01-01

    An extensive review of the literature and studies relating to performance, medical, operational, and legal data regarding pilot aging issues was performed in order to determine what evidence there is, if any, to support mandatory pilot retirement. Popular misconceptions about aging, including the failure to distinguish between the normal aging process and disease processes that occur more frequently in older individuals, continue to contribute to much of the misunderstanding and controversy that surround this issue. Results: Review of medical data related to the pilot aging issue indicate that recent improvement in medical diagnostics and treatment technology have made it possible to identify to a high degree individuals who are at risk for developing sudden incapacitating illness and for treating those with disqualifying medical conditions. Performance studies revealed that after controlling for the presence of disease states, older pilots are able to perform as well as younger pilots on many performance tasks. Review of accident data showed that older, healthy pilots do not have higher accident rates than younger pilots, and indeeed, evidence suggests that older pilots have an advantage in the cockpit due to higher experience levels. The Man-Machine-Mission-Environment interface of factors can be managed through structured, supervised, and enhanced operations, maintenance, flight reviews, and safety procedures in order to ensure safe and productive operations by reducing the margin of error and by increasing the margin of safety. Conclusions: There is no evidence indicating any specific age as an arbitrary cut-off point for pilots to perform their fight duties. A combination of regular medical screening, performance evaluation, enhanced operational maintenance, and safety procedures can most effectively ensure a safe pilot population than can a mandatory retirement policy based on arbitrary age restrictions.

  1. Protecting America's Aged, Children, and Poor. Multi-Generational Needs; Multi-Generational Solutions. A Public Forum Presented by the Chairman of the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, Second Session, in Conjunction with the Annual Meeting of the American Public Health Association.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document contains materials from a Congressional public forum which focused on multigenerational approaches to the health and economic problems of Americans. Introductory remarks are included from Fernando Torres-Gil, staff director of the House Select Committee on Aging; Victor Sidel, president of the American Public Health Association…

  2. Introductory materials for committee members: 1) instructions for the Los Alamos National Laboratory fiscal year 2010 capability reviews 2) NPAC strategic capability planning 3) Summary self-assessment for the nuclear and particle physics, astrophysics an

    SciTech Connect

    Redondo, Antonio

    2010-01-01

    Los Alamos National Laboratory (LANL) uses external peer review to measure and continuously improve the quality of its science, technology and engineering (STE). LANL uses capability reviews to assess the STE quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. STE capabilities are define to cut across directorates providing a more holistic view of the STE quality, integration to achieve mission requirements, and mission relevance. The scope of these capabilities necessitate that there will be significant overlap in technical areas covered by capability reviews (e.g., materials research and weapons science and engineering). In addition, LANL staff may be reviewed in different capability reviews because of their varied assignments and expertise. LANL plans to perform a complete review of the Laboratory's STE capabilities (hence staff) in a three-year cycle. The principal product of an external review is a report that includes the review committee's assessments, commendations, and recommendations for STE. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). This report will be used by Laboratory Management for STE assessment and planning. The report is also provided to the Department of Energy (DOE) as part of LANL's Annual Performance Plan and to the Los Alamos National Security (LANS) LLC's Science and Technology Committee (STC) as part of its responsibilities to the LANS Board of Governors.

  3. A Review of Information for Managing Aging in Nuclear Power Plants

    SciTech Connect

    WC Morgan; JV Livingston

    1995-09-01

    Age related degradation effects in safety related systems of nuclear power plants should be managed to prevent safety margins from eroding below the acceptable limits provided in plant design bases. The Nuclear Plant Aging Research (NPAR) Pro- gram, conducted under the auspices of the U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, and other related aging management programs are developing technical information on managing aging. The aging management process central to these efforts consists of three key elements: 1) selecting structures, systems, and components (SSCs) in which aging should be controlled; 2) understanding the mechanisms and rates of degradation in these SSCs; and 3) managing degradation through effective inspection, surveillance, condition monitoring, trending, record keeping, mainten- ance, refurbishment, replacement, and adjustments in the operating environment and service conditions. This document concisely reviews and integrates information developed under the NPAR Program and other aging management studies and other available information related to understanding and managing age-related degradation effects and provides specific refer- ences to more comprehensive information on the same subjects.

  4. The Age Conundrum: A Scoping Review of Younger Age or Adolescent and Young Adult as a Risk Factor for Clinical Distress, Depression, or Anxiety in Cancer.

    PubMed

    Lang, Michael J; David, Victoria; Giese-Davis, Janine

    2015-12-01

    This scoping review was conducted to understand the extent, range, and nature of current research on adolescents and young adults (AYA) with cancer and distress, depression, and anxiety (DDA). This information is necessary to find and aggregate valuable data on the AYA population embedded in generalized studies of DDA. Keyword searches of six relevant electronic databases identified 2156 articles, with 316 selected for abstract review and 40 for full text review. Full-text reviews and data extraction resulted in 34 studies being included, which ranged widely in design, sample size, age-range categorization, analysis methods, DDA measurement tool, overall study rigor, and quality of evidence. Studies very seldom reported using theory to guide their age categorization, with only four studies giving any rationale for their age-group definitions. All 34 studies found a significant association between at least one DDA construct and the younger age group relative to the older age groups at some point along the cancer trajectory. However, age as an independent risk factor for DDA is still unclear, as the relationship could be confounded by other age-related factors. Despite the wide range of definitions and effect sizes in the studies included in this review, one thing is clear: adolescents and young adults, however defined, are a distinct group within the cancer population with an elevated risk of DDA. Widespread adoption of a standard AYA age-range definition will be essential to any future meta-analytical psycho-oncology research in this population.

  5. The Age Conundrum: A Scoping Review of Younger Age or Adolescent and Young Adult as a Risk Factor for Clinical Distress, Depression, or Anxiety in Cancer.

    PubMed

    Lang, Michael J; David, Victoria; Giese-Davis, Janine

    2015-12-01

    This scoping review was conducted to understand the extent, range, and nature of current research on adolescents and young adults (AYA) with cancer and distress, depression, and anxiety (DDA). This information is necessary to find and aggregate valuable data on the AYA population embedded in generalized studies of DDA. Keyword searches of six relevant electronic databases identified 2156 articles, with 316 selected for abstract review and 40 for full text review. Full-text reviews and data extraction resulted in 34 studies being included, which ranged widely in design, sample size, age-range categorization, analysis methods, DDA measurement tool, overall study rigor, and quality of evidence. Studies very seldom reported using theory to guide their age categorization, with only four studies giving any rationale for their age-group definitions. All 34 studies found a significant association between at least one DDA construct and the younger age group relative to the older age groups at some point along the cancer trajectory. However, age as an independent risk factor for DDA is still unclear, as the relationship could be confounded by other age-related factors. Despite the wide range of definitions and effect sizes in the studies included in this review, one thing is clear: adolescents and young adults, however defined, are a distinct group within the cancer population with an elevated risk of DDA. Widespread adoption of a standard AYA age-range definition will be essential to any future meta-analytical psycho-oncology research in this population. PMID:26697266

  6. Update of technical coordinating committee activities

    SciTech Connect

    Alvarado, R.A.

    1995-12-31

    The Technical Coordinating Committee has its origins in the earliest days of implementing the Low-Level Radioactive Waste Policy Act. Between 1982 and 1985, individuals in several of the states felt that coordination among the states would be beneficial to all by affording states a cost-effective method for sharing ideas, discussing alternatives, and presenting solutions to common problems. At the current time, the committee comprises members from each of the sited states. Various compacts, federal agencies, and industry groups participate in committee activities. The Low-Level Management Program provides support for the committee through the provision of logistical support and limited manpower allocation. Activities of the committee have recently focused on waste treatment and minimization technologies. The committee also has worked diligently to see the review of the 3RSTAT computer code completed. The committee has taken a position on various regulatory proposals the past year. The committee expects to continue its work until new sites are brought online.

  7. Beverages and body weight: challenges in the evidence-based review process of the Carbohydrate Subcommittee from the 2010 Dietary Guidelines Advisory Committee.

    PubMed

    Slavin, Joanne

    2012-11-01

    Concern about the role of beverages, especially those containing sugar, in the obesity epidemic continues to escalate. Bans on sugar-sweetened beverages and chocolate milk have expanded from the school cafeteria to the ballpark and convenience store. This review describes the experience of the 2010 Dietary Guidelines Advisory Committee (DGAC) in conducting an evidence-based review of dietary exposure and health outcomes. The following four topics relevant to fluids and body weight were reviewed: added sugar, noncaloric sweeteners, food form and body weight, and macronutrients and satiety. There were limited and conflicting data on how liquids and solids affect energy intake and body weight. Fluid intake is typically not tracked in prospective, cohort longitudinal studies; thus, data are not available on fluid intake and health status from studies using the strongest epidemiologic designs. Despite public perception that beverages are linked to increased body weight compared with whole foods, evidence-based reviews of this topic do not support that liquid calories are processed differently in the body. The practical recommendation to replace caloric beverages with water as an aid to control weight is based on calorie reduction, rather than a link between added-sugar intake and obesity.

  8. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review.

    PubMed

    Ali, Sumbul; Garcia, Jose M

    2014-01-01

    By the year 2050, individuals over the age of 65 years will comprise 20% of the US population. Loss of muscle mass and strength is common in this age group and it is associated with increased dependence, frailty and mortality. Sarcopenia, defined as the loss of muscle mass and function associated with aging, and cachexia, defined as weight loss due to an underlying illness, are muscle wasting disorders of particular relevance in the aging population, but they go largely unrecognized. In this review we highlight the common pathophysiological mechanisms underlying muscle loss in sarcopenia and cachexia, the factors unique to each condition and means of diagnosing and differentiating them clinically. Therapeutic options including exercise, nutritional therapy, androgens and growth hormone as well as their practical limitations are discussed. We also shed light on newer agents being developed as potential therapeutic options for wasting diseases. PMID:24731978

  9. 78 FR 69392 - Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... of the Secretary Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory... advisory committee meeting of the Defense Advisory Committee on Military Personnel Testing. The purpose of the meeting is to review planned changes and progress in developing computerized tests for...

  10. 76 FR 8751 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... Committee: Center for Scientific Review Special Emphasis Panel; Small Business: Non-HIV Anti-Infective... Panel; BDCN Aging, Eye, and Neurodegeneration Special Emphasis Panel. Date: March 8-9, 2011. Time: 9...

  11. Youth Representation on County Government Committees: Youth in Governance in Kenosha County, Wisconsin

    ERIC Educational Resources Information Center

    Calvert, Matthew; de Montmollin, John; Winnett, Tedi

    2015-01-01

    The Kenosha County Youth in Governance program was created to build leadership skills and civic engagement opportunities for high school-aged students by placing two youth representatives on each of the Kenosha County Board of Supervisors standing committees. In reviewing data from 3 years of youth participants, the program was effective in…

  12. 78 FR 39289 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  13. 75 FR 20844 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  14. 78 FR 21354 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  15. 75 FR 70004 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  16. 75 FR 60458 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  17. 77 FR 6113 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC's) Advisory Committee on Diversity for Communications in the Digital...

  18. 77 FR 57085 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  19. 75 FR 53694 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  20. 76 FR 64348 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  1. 75 FR 6031 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital...

  2. A systematic review on the role of environmental toxicants in stem cells aging.

    PubMed

    Hodjat, Mahshid; Rezvanfar, Mohammad Amin; Abdollahi, Mohammad

    2015-12-01

    Stem cells are an important target for environmental toxicants. As they are the main source for replenishing of organs in the body, any changes in their normal function could affect the regenerative potential of organs, leading to the appearance of age-related disease and acceleration of the aging process. Environmental toxicants could exert their adverse effect on stem cell function via multiple cellular and molecular mechanisms, resulting in changes in the stem cell differentiation fate and cell transformation, and reduced self-renewal capacity, as well as induction of stress-induced cellular senescence. The present review focuses on the effect of environmental toxicants on stem cell function associated with the aging process. We categorized environmental toxicants according to their preferred molecular mechanism of action on stem cells, including changes in genomic, epigenomic, and proteomic levels and enhancing oxidative stress. Pesticides, tobacco smoke, radiation and heavy metals are well-studied toxicants that cause stem cell dysfunction via induction of oxidative stress. Transgenerational epigenetic changes are the most important effects of a variety of toxicants on germ cells and embryos that are heritable and could affect health in the next several generations. A better understanding of the underlying mechanisms of toxicant-induced stem cell aging will help us to develop therapeutic intervention strategies against environmental aging. Meanwhile, more efforts are required to find the direct in vivo relationship between adverse effect of environmental toxicants and stem cell aging, leading to organismal aging.

  3. The evolutionary theories of aging revisited--a mini-review.

    PubMed

    Ljubuncic, Predrag; Reznick, Abraham Z

    2009-01-01

    This short review portrays the evolutionary theories of aging in the light of the existing discoveries from genomic and molecular genetic studies on aging and longevity. At the outset, an historical background for the development of the evolutionary theories of aging is presented through the works of August Weismann (programmed death and the germ plasm theories) including his exceptional theoretical postulation, later experimentally validated by the existence of cell division limits. Afterwards, the theory of mutation accumulation of Peter Medawar and the theory modification by Charlesworth (late-life mortality plateau) are presented as well as the antagonistic pleiotropy hypothesis of George Williams, and the disposable soma theory of Kirkwood and Holliday. These theories are discussed in the light of the different research studies, which include studies on insulin signaling and longevity, the possibility that nuclear factor kappa B may be a major mediator of aging, studies of anti-aging Sirtuins and studies on heat shock proteins and longevity and on gene sets as biomarkers of aging. Finally, the proposals for future research in biogerontology, such as studies on the control of protein synthesis, validation of biomarkers of aging, understanding the biochemistry of longevity and research in the field of gerontologic pathology are presented. Likewise, further attention is suggested regarding the work on telomere shortening, stem cells and studies on understanding the biochemical and molecular basis for longevity in centenarians. PMID:19202326

  4. Successful Aging and Its Discontents: A Systematic Review of the Social Gerontology Literature

    PubMed Central

    Martinson, Marty; Berridge, Clara

    2015-01-01

    Purpose of the Study: The purpose of this study was to analyze the range of critiques of successful aging models and the suggestions for improvement as expressed in the social gerontology literature. Design and Methods: We conducted a systematic literature review using the following criteria: journal articles retrieved in the Abstracts in Social Gerontology, published 1987–2013, successful aging/ageing in the title or text (n = 453), a critique of successful aging models as a key component of the article. Sixty-seven articles met the criteria. Qualitative methods were used to identify key themes and inductively configure meanings across the range of critiques. Results: The critiques and remedies fell into 4 categories. The Add and Stir group suggested a multidimensional expansion of successful aging criteria and offered an array of additions. The Missing Voices group advocated for adding older adults’ subjective meanings of successful aging to established objective measures. The Hard Hitting Critiques group called for more just and inclusive frameworks that embrace diversity, avoid stigma and discrimination, and intervene at structural contexts of aging. The New Frames and Names group presented alternative ideal models often grounded in Eastern philosophies. Implications: The vast array of criteria that gerontologists collectively offered to expand Rowe and Kahn’s original successful model is symptomatic of the problem that a normative model is by definition exclusionary. Greater reflexivity about gerontology’s use of “successful aging” and other normative models is needed. PMID:24814830

  5. Prevalence of Chlamydia trachomatis among Childbearing Age Women in India: A Systematic Review

    PubMed Central

    Robertson, Jamie M.; Tang, Gong; Haggerty, Catherine L.

    2016-01-01

    Background. Infection with Chlamydia trachomatis (CT) can lead to reproductive sequelae. Information on the general population of childbearing age women in India is sparse. We reviewed the literature on CT prevalence within the general population of reproductive aged women in order to improve the efforts of public health screening programs and interventions. Objective. To conduct a literature review to determine the prevalence of Chlamydia trachomatis among childbearing age women in India. Search Strategy. Ovid Medline and PubMed databases were searched for articles from January 1, 2003, through December 31, 2014. Search terms included “Chlamydia trachomatis”, “CT”, “prevalence”, “India”, and “sexually transmitted infections”. Selection Criteria. Studies on prevalence data for CT among women of childbearing age (15–45) living in India were included. Data Collection and Analysis. Articles that met the inclusion criteria were extracted by two readers and discrepancies solved through discussion. Results. Reported prevalence of active CT infection among lower risk groups ranged from 0.1% to 1.1% and in higher risk group from 2.7% to 28.5%. Conclusion. CT prevalence among women in India is comparable to other countries. Screening programs to prevent adverse outcomes among Indian women of childbearing age and their offspring are warranted. PMID:27672303

  6. Prevalence of Chlamydia trachomatis among Childbearing Age Women in India: A Systematic Review

    PubMed Central

    Robertson, Jamie M.; Tang, Gong; Haggerty, Catherine L.

    2016-01-01

    Background. Infection with Chlamydia trachomatis (CT) can lead to reproductive sequelae. Information on the general population of childbearing age women in India is sparse. We reviewed the literature on CT prevalence within the general population of reproductive aged women in order to improve the efforts of public health screening programs and interventions. Objective. To conduct a literature review to determine the prevalence of Chlamydia trachomatis among childbearing age women in India. Search Strategy. Ovid Medline and PubMed databases were searched for articles from January 1, 2003, through December 31, 2014. Search terms included “Chlamydia trachomatis”, “CT”, “prevalence”, “India”, and “sexually transmitted infections”. Selection Criteria. Studies on prevalence data for CT among women of childbearing age (15–45) living in India were included. Data Collection and Analysis. Articles that met the inclusion criteria were extracted by two readers and discrepancies solved through discussion. Results. Reported prevalence of active CT infection among lower risk groups ranged from 0.1% to 1.1% and in higher risk group from 2.7% to 28.5%. Conclusion. CT prevalence among women in India is comparable to other countries. Screening programs to prevent adverse outcomes among Indian women of childbearing age and their offspring are warranted.

  7. US medical researchers, the Nuremberg Doctors Trial, and the Nuremberg Code. A review of findings of the Advisory Committee on Human Radiation Experiments.

    PubMed

    Faden, R R; Lederer, S E; Moreno, J D

    1996-11-27

    The Advisory Committee on Human Radiation Experiments (ACHRE), established to review allegations of abuses of human subjects in federally sponsored radiation research, was charged with identifying appropriate standards to evaluate the ethics of cold war radiation experiments. One central question for ACHRE was to determine what role, if any, the Nuremberg Code played in the norms and practices of US medical researchers. Based on the evidence from ACHRE's Ethics Oral History Project and extensive archival research, we conclude that the Code, at the time it was promulgated, had little effect on mainstream medical researchers engaged in human subjects research. Although some clinical investigators raised questions about the conduct of research involving human beings, the medical profession did not pursue this issue until the 1960s.

  8. 75 FR 35821 - National Institute On Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... HUMAN SERVICES National Institutes of Health National Institute On Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Member Conflict SEP, Date: June 24, 2010. Time...: Ramesh Vemuri, PhD, Chief, Scientific Review Branch, National Institute on Aging, National Institutes...

  9. 77 FR 1941 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; GEMSSTAR. Date: January 27, 2012. Time: 8 a.m...., Scientific Review Officer, National Institute on Aging, Gateway Building, Rm. 2C212, 7201 Wisconsin...

  10. 76 FR 6628 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Sex Differences in Health and Survival. Date..., Scientific Review Officer, National Institutes on Aging, National Institutes of Health, 7201 Wisconsin...

  11. 76 FR 5391 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Pepper Centers. Date: February 17-18, 2011..., Scientific Review Branch, National Institute on Aging, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  12. 75 FR 57965 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Member Conflict SEP. Date: October 4, 2010... Review Branch, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue,...

  13. 12 CFR 620.30 - Audit committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to the audit committee. Each institution is responsible for providing monetary and nonmonetary... policy changes relating to preparation of financial statements; and review annual and quarterly reports prior to release. After the audit committee reviews a financial policy, procedure, or report, it...

  14. Aging and Sexual Orientation: A 25-Year Review of the Literature

    PubMed Central

    Fredriksen-Goldsen, Karen I.; Muraco, Anna

    2013-01-01

    In a review of 58 articles published between 1984 and 2008, this article synthesizes the recent state of social research on older lesbian, gay male, and bisexual adults in order to summarize existing knowledge about these groups, to guide future research on aging, and to identify the substantive issues affecting their lives. Based on a life-course perspective, the primary research domains identified include the interplay of lives and historical times and linked and interdependent lives. After reviewing the literature in each of these areas, the article presents an examination of the strengths and limitations of the body of knowledge and an outline of a blueprint for future research. PMID:24098063

  15. Organization, review, and administration of cooperative studies (Greenberg Report): a report from the Heart Special Project Committee to the National Advisory Heart Council, May 1967.

    PubMed

    1988-06-01

    Cooperative studies have been designed as a means of obtaining definite answers to significant questions not readily answerable by other means. Such studies should be initiated only if an important problem needs a rapid solution, the study is feasible and likely to answer the problem, and strong and stable leadership are assured. Protocol and operating procedures must be kept as simple as possible. Control of performance at all levels must be built into the structure. Organizational components should include: (a) a Policy or Advisory Board, (b) an Executive or Steering Committee, (c) a Coordinating Center, and (d) data-contributing participants. All of these components must interrelate with each other and with National Heart Institute staff and, through the staff, with scientific review groups and the National Advisory Heart Council. A chart of organization is shown in Figure 1. The most important position is that of Chairman of the Steering Committee; the key component is the Coordinating Center. The performance of the Coordinating Center is continuously dependent on full-time, highly disciplined leadership that must continually maintain active lines of communication with all participants. Failure to achieve this seriously undermines the effectiveness and value of the study. Participation in a cooperative study, with required adherence to a common protocol, can divert some scientists from original research. Conversely, others may be introduced to research methodology through participation. The benefits that can be achieved only through cooperative efforts must be carefully balanced against any adverse effects of encouraging large numbers of investigators to work in cooperative studies. Exceedingly complex value judgments are required of reviewers, who must constantly keep in mind the need to maintain a reasonable balance within the funds appropriated for research. Their deliberations should include an evaluation of technical approaches, organization

  16. Review of Veterans' Education Programs. Hearing before the Committee on Veterans' Affairs, United States Senate, Ninety-Eighth Congress, First Session on S. 8, S. 9, S. 667, and Related Bills.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Veteran's Affairs.

    This report of a hearing before the Committee on Veterans' Affairs, United States Senate, provides information on veterans' educational programs. The focus is a review of several legislative proposals regarding educational programs and benefits for veterans and service personnel. Texts of the three bills (All-Volunteer Force Educational Assistance…

  17. Regulatory instrument review: Aging management of LWR cables, containment and basemat, reactor coolant pumps, and motor-operated valves

    SciTech Connect

    Werry, E.V.; Somasundaram, S.

    1995-09-01

    The results of Stage 2 of the Regulatory Instrument Review are presented in this volume. Selected regulatory instruments, such as the Code of Federal Regulations (CFR), US Nuclear Regulatory Commission (NRC), Regulatory Guides, and ASME Codes, were investigated to determine the extent to which these regulations apply aging management to selected safety-related components in nuclear power plants. The Regulatory Instrument Review was funded by the NRC under the Nuclear Plant Aging Research (NPAR) program. Stage 2 of the review focused on four safety-related structures and components; namely, cables, containment and basemat, reactor coolant pumps, and motor-operated valves. The review suggests that the primary-emphasis of the regulatory instruments was on the design, construction, start-up, and operation of a nuclear power plant, and that aging issues were primarily addressed after an aging-related problem was recognized. This Stage 2 review confirms the results of the prior review; (see Regulatory Instrument Review: Management of Aging of LWR Major Safety-Related Components NUREG/CR-5490. The observations indicate that the regulations generally address management of age-related degradation indirectly. Specific age-related degradation phenomena frequently are dealt with in bulletins and notices or through generic issues, letters, etc. The major recommendation of this report, therefore, is that the regulatory instruments should more directly and explicitly address the aging phenomenon and the management of the age-related degradation process.

  18. Botanical extracts as anti-aging preparations for the skin: a systematic review.

    PubMed

    Hunt, Katherine J; Hung, Shao Kang; Ernst, Edzard

    2010-12-01

    Although topical creams and other anti-aging products purport to reduce the appearance of aging and skin wrinkling, there has been no critical analysis in the scientific literature of their effectiveness. This systematic review critically evaluates the evidence for the effectiveness or efficacy of botanical treatments in reducing skin aging and wrinkling. MEDLINE, Embase, CINAHL®, CENTRAL and AMED databases were searched from their inception until October 2009. Reference lists of retrieved articles were hand-searched. Manufacturers and professional associations were contacted in order to identify further non-published studies. No language restrictions were applied. Only randomized clinical trials or controlled clinical trials assessing the effectiveness of botanical extracts in reducing wrinkling and aging of the skin were included. Data were extracted by two independent reviewers and methodological quality was assessed using the Jadad score and key aspects of the Cochrane risk of bias tool. Of 36 potentially relevant studies, 11 trials of botanical extracts for reducing skin wrinkling and the appearance of aging met all the inclusion criteria. No trials were identified following contact with anti-aging and cosmetic organizations, companies and professional bodies. A significant reduction in skin wrinkling was noted for date kernel extract, cork extract, soy extract, Rosaceae and peony extract. No significant reduction was noted for green tea, Vitaphenol® (a combination of green and white teas, mangosteen and pomegranate extract) or maca root. All trials were of poor methodological quality. Adverse effects were frequently not reported. In summary, there is some weak evidence to suggest that several botanical extracts may be effective in reducing the appearance of skin aging but no evidence that this effect is enduring. Independent replications with larger, more diverse samples, longer treatment durations and more rigorous study designs are required to validate

  19. Screening for developmental delay among children aged 1-4 years: a systematic review

    PubMed Central

    Warren, Rachel; Kenny, Meghan; Bennett, Teresa; Fitzpatrick-Lewis, Donna; Ali, Muhammad Usman; Sherifali, Diana; Raina, Parminder

    2016-01-01

    Background: Existing guidelines on screening children less than 5 years of age for developmental delay vary. In this systematic review, we synthesized the literature on the effectiveness and harms of screening for developmental delay in asymptomatic children aged 1-4 years. Methods: We searched MEDLINE, Embase and PsychINFO for relevant articles published to June 16, 2015. We identified studies that included children aged 1-4 years who were not at high risk of developmental delay, screened in a primary care setting. Randomized trials and controlled cohort studies were considered for benefits (cognitive, academic and functional outcomes); no restrictions on study design were imposed for the review of harms. Results: Two studies were included. One used the Ages and Stages Questionnaire II for screening and reported significantly more referrals to early intervention in the intervention groups than in the control group (relative risk [RR] 1.95, 95% confidence interval [CI] 1.49-2.54, in the intervention group with office support and RR 1.71, 95% CI 1.30-2.25, in the intervention group without office support). The time to referral was 70% shorter in the intervention group with office support (rate ratio 0.30, 95% CI 0.19-0.48) and 64% shorter in the intervention group without office support (rate ratio 0.36, 95% CI 0.23-0.59), compared with the control group. The other study used the VroegTijdige Onderkenning Ontwikkelingsstoornissen Language Screening instrument to screen children aged 15 months at enrolment for language delay. It reported no differences between groups in academic performance outcomes at age 8 years. Interpretation: The evidence on screening for developmental delay in asymptomatic children aged 1-4 years is inconclusive. Further research with longer-term outcomes is needed to inform decisions about screening and screening intervals. PMID:27226967

  20. Botanical extracts as anti-aging preparations for the skin: a systematic review.

    PubMed

    Hunt, Katherine J; Hung, Shao Kang; Ernst, Edzard

    2010-12-01

    Although topical creams and other anti-aging products purport to reduce the appearance of aging and skin wrinkling, there has been no critical analysis in the scientific literature of their effectiveness. This systematic review critically evaluates the evidence for the effectiveness or efficacy of botanical treatments in reducing skin aging and wrinkling. MEDLINE, Embase, CINAHL®, CENTRAL and AMED databases were searched from their inception until October 2009. Reference lists of retrieved articles were hand-searched. Manufacturers and professional associations were contacted in order to identify further non-published studies. No language restrictions were applied. Only randomized clinical trials or controlled clinical trials assessing the effectiveness of botanical extracts in reducing wrinkling and aging of the skin were included. Data were extracted by two independent reviewers and methodological quality was assessed using the Jadad score and key aspects of the Cochrane risk of bias tool. Of 36 potentially relevant studies, 11 trials of botanical extracts for reducing skin wrinkling and the appearance of aging met all the inclusion criteria. No trials were identified following contact with anti-aging and cosmetic organizations, companies and professional bodies. A significant reduction in skin wrinkling was noted for date kernel extract, cork extract, soy extract, Rosaceae and peony extract. No significant reduction was noted for green tea, Vitaphenol® (a combination of green and white teas, mangosteen and pomegranate extract) or maca root. All trials were of poor methodological quality. Adverse effects were frequently not reported. In summary, there is some weak evidence to suggest that several botanical extracts may be effective in reducing the appearance of skin aging but no evidence that this effect is enduring. Independent replications with larger, more diverse samples, longer treatment durations and more rigorous study designs are required to validate

  1. Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).

    PubMed

    Fernandez, O; Arnal-Garcia, C; Arroyo-Gonzalez, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; de Las Heras, V; Garcia-Merino, J A; Hernandez-Perez, M A; Izquierdo, G; Matas, E; Meca-Lallana, J E; Mendibe-Bilbao, M M; Munoz-Garcia, D; Olascoaga, J; Oreja-Guevara, C; Prieto, J M; Ramio-Torrenta, Ll; Rodriguez-Antiguedad, A; Saiz, A; Tellez, N; Villar, L M; Tintore, M; Grupo Post-Ectrims, Grupo Post-Ectrims

    2013-09-16

    The most relevant data presented at the 28th edition of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) held in October 2012 in France have been summarised in the fifth edition of the Post-ECTRIMS Expert Meeting held in Madrid in October 2012. This review is the result of the meeting, which is being published in three parts. This second part of the Post-ECTRIMS review discusses the biology of recovery and remyelination in multiple sclerosis (MS) as well as the different repair and endogenous and exogenous remyelination strategies currently being evaluated based on the fact that resident microglia and oligodendroglial progenitor cells have been implicated in the remyelination process. This review also discusses the current state and future use of biomarkers in MS and proposes as markers of neurodegeneration the following: T2 lesion volume and brain atrophy using MRI and the loss of the ganglion cell layer as assessed by optical coherence tomography. A greater future utility for double inversion recovery (DIR) sequences is proposed to correlate cognitive impairment with MS impairment, given its higher diagnostic yield in locating and defining cortical lesions. The availability of novel biomarkers in the future requires strict validation. In this context, this paper proposes possible areas of action to improve the current situation and also presents the latest research results in identifying potential candidates with useful diagnostic characteristics, prognostic characteristics, treatment responses, and safety procedures.

  2. 78 FR 72746 - Activities of the International Telecommunication Advisory Committee and Preparations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Activities of the International Telecommunication Advisory Committee and Preparations for Upcoming International Telecommunications Meetings This notice announces a meeting of the Department of State's International Telecommunication Advisory Committee (ITAC) to review the activities of the committee over...

  3. Genetics and age-related macular degeneration: a practical review for the clinician

    PubMed Central

    Schwartz, Stephen G; Hampton, Blake M; Kovach, Jaclyn L; Brantley, Milam A

    2016-01-01

    Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients. PMID:27445455

  4. Fingermark age determinations: Legal considerations, review of the literature and practical propositions.

    PubMed

    Girod, A; Ramotowski, R; Lambrechts, S; Misrielal, P; Aalders, M; Weyermann, C

    2016-05-01

    The question of the age of fingermarks is often raised in investigations and trials when suspects admit that they have left their fingermarks at a crime scene but allege that the contact occurred at a different time than the crime and for legal reasons. In the first part of this review article, examples from American appellate court cases will be used to demonstrate that there is a lack of consensus among American courts regarding the admissibility and weight of testimony from expert witnesses who provide opinions about the age of fingermarks. Of course, these issues are not only encountered in America but have also been reported elsewhere, for example in Europe. The disparity in the way fingermark dating cases were managed in these examples is probably due to the fact that no methodology has been validated and accepted by the forensic science community so far. The second part of this review article summarizes the studies reported on fingermark dating in the literature and highlights the fact that most proposed methodologies still suffer from limitations preventing their use in practice. Nevertheless, several approaches based on the evolution of aging parameters detected in fingermark residue over time appear to show promise for the fingermark dating field. Based on these approaches, the definition of a formal methodological framework for fingermark dating cases is proposed in order to produce relevant temporal information. This framework identifies which type of information could and should be obtained about fingermark aging and what developments are still required to scientifically address dating issues.

  5. Weld repair of aged Cr-Mo steel piping -- A review of literature

    SciTech Connect

    Viswanathan, R.; Gandy, D.

    2000-02-01

    Power plant piping operating at elevated temperatures is subject to several types of service aging-related degradation, such as softening, spheroidization, embrittlement, and creep. When cracks are found in these components, weld repair is often employed to ensure continued operation. The efficacy of the weld repairs in terms of extending the life of the aged components has, however, not been documented quantitatively. The Electric Power Research institute (EPRI) has recently undertaken a comprehensive study to evaluate weld repairs performed to aged piping. In connection with this study, results from other worldwide activities have been reviewed, leading to significant conclusions regarding weld repair. this review of results from several worldwide studies has confirmed that aged high-temperature piping can be successfully weld repaired to gain additional lives in excess of several decades. The key aspects of successful weld repair include excavation and removal of all prior creep cavitation damage, elimination of external bending stresses, and implementation of good welding practice. From merely a creep rupture point of view, postweld heat treatment (PWHT) has been concluded to be superfluous by several authors. Temperbead repairs appear to offer a promising alternative to PWHT repairs from a creep, tensile, and toughness standpoint. Choice of the repair process ultimately is dictated by many considerations such as toughness, notch sensitivity, residual stresses and hydrogen embrittlement susceptibility. Several reports suggest that gas tungsten arc welding (GTAW) repairs may outperform shielded metal arc welding (SMAW) repairs with or without PWHT.

  6. Fingermark age determinations: Legal considerations, review of the literature and practical propositions.

    PubMed

    Girod, A; Ramotowski, R; Lambrechts, S; Misrielal, P; Aalders, M; Weyermann, C

    2016-05-01

    The question of the age of fingermarks is often raised in investigations and trials when suspects admit that they have left their fingermarks at a crime scene but allege that the contact occurred at a different time than the crime and for legal reasons. In the first part of this review article, examples from American appellate court cases will be used to demonstrate that there is a lack of consensus among American courts regarding the admissibility and weight of testimony from expert witnesses who provide opinions about the age of fingermarks. Of course, these issues are not only encountered in America but have also been reported elsewhere, for example in Europe. The disparity in the way fingermark dating cases were managed in these examples is probably due to the fact that no methodology has been validated and accepted by the forensic science community so far. The second part of this review article summarizes the studies reported on fingermark dating in the literature and highlights the fact that most proposed methodologies still suffer from limitations preventing their use in practice. Nevertheless, several approaches based on the evolution of aging parameters detected in fingermark residue over time appear to show promise for the fingermark dating field. Based on these approaches, the definition of a formal methodological framework for fingermark dating cases is proposed in order to produce relevant temporal information. This framework identifies which type of information could and should be obtained about fingermark aging and what developments are still required to scientifically address dating issues. PMID:27044033

  7. The anorexia of ageing: physiopathology, prevalence, associated comorbidity and mortality. A systematic review.

    PubMed

    Malafarina, Vincenzo; Uriz-Otano, Francisco; Gil-Guerrero, Lucía; Iniesta, Raquel

    2013-04-01

    The physiological processes of ageing and factors prevalent in the elderly such as comorbidities and polypharmacy often cause loss of appetite in the elderly, which we call anorexia of ageing. Social factors, together with changes in the sensory organs, can be important causes of a reduction in both appetite and ingestion. This review assesses the regulation of appetite in the elderly and the development of anorexia of ageing. It also examines the prevalence of this type of anorexia, its associated comorbidities and mortality rates. We have reviewed 27 studies, with a total of 6208 patients. These reported changes in the secretion and response of both central and peripheral hormones that regulate appetite. Anorexia, very prevalent among hospitalized and institutionalized elderly people, is associated with comorbidity and represents a predictive factor for mortality. No treatment for it has been proved to be effective. The mechanism regulating ingestion in elderly people is complex and difficult to resolve. Comorbidity as a cause or a consequence of anorexia of ageing has become a research field of great interest in geriatrics. A correct nutritional evaluation is a fundamental part of an integrated geriatric assessment.

  8. e-Health Interventions for Healthy Aging: A Systematic Review Protocol.

    PubMed

    Gagnon, Marie-Pierre; Beogo, Idrissa; Buyl, Ronald

    2016-01-01

    e-Health interventions could contribute to healthy aging (HA) but their effectiveness has not been synthesised. This study aims to systematically review the effectiveness of e-health interventions for supporting HA. We will perform standardized searches to identify experimental and quasi-experimental studies evaluating the effectiveness of e-health interventions for HA. Outcomes of interest are: wellbeing, quality of life, activities of daily living, leisure activities, knowledge, evaluation of care, social support, skill acquisition and healthy behaviours. We will also consider adverse effects such as social isolation, anxiety, and burden on informal caregivers. Two reviewers will independently assess studies for inclusion and extract data using a standardised tool. We will calculate effect sizes related to e-health interventions. If not possible, we will present the findings in a narrative form. This systematic review will provide unique knowledge on the effectiveness of e-health interventions for supporting HA. PMID:27332428

  9. e-Health Interventions for Healthy Aging: A Systematic Review Protocol.

    PubMed

    Gagnon, Marie-Pierre; Beogo, Idrissa; Buyl, Ronald

    2016-01-01

    e-Health interventions could contribute to healthy aging (HA) but their effectiveness has not been synthesised. This study aims to systematically review the effectiveness of e-health interventions for supporting HA. We will perform standardized searches to identify experimental and quasi-experimental studies evaluating the effectiveness of e-health interventions for HA. Outcomes of interest are: wellbeing, quality of life, activities of daily living, leisure activities, knowledge, evaluation of care, social support, skill acquisition and healthy behaviours. We will also consider adverse effects such as social isolation, anxiety, and burden on informal caregivers. Two reviewers will independently assess studies for inclusion and extract data using a standardised tool. We will calculate effect sizes related to e-health interventions. If not possible, we will present the findings in a narrative form. This systematic review will provide unique knowledge on the effectiveness of e-health interventions for supporting HA.

  10. Old and Young: Generations at the Crossroads. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Seventh Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    These hearings explore the gap between young and old and ways to bridge that gap. Statements from each of the eight members of the committee focus on the relationship between youths and older adults, the role of the family, and the need for strengthening inter-generational relationships. Statements are presented from witnesses including child…

  11. Medicare: Comparison of Catastrophic Health Insurance Proposals--An Update. Briefing Report to the Chairman, Select Committee on Aging, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of Human Resources.

    This document updates a recent report by the General Accounting Office (GAO) which compared Medicare catastrophic health insurance proposals. The update includes H.R. 2470, as passed by the House of Representatives and S. 1127, as reported by the Senate Committee on Finance. An introduction explains the roles of Medicare, Medicaid, the Veterans…

  12. Corporate Retiree Health Benefits: Here Today, Gone Tomorrow? Hearing before the Select Committee on Aging. House of Representatives, Ninety-Eighth Congress, Second Session (June 27, 1984).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document contains witness testimonies and prepared statements from the Congressional hearing called to examine the rise in health care costs and its effect on retirees' health benefits. Opening statements are provided from committee members. The retiree's perspective is given by a retiree and a granddaughter of a retiree who have had their…

  13. Violent Crime Against the Elderly: A New Jersey Perspective. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session (Plainfield, NJ).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document contains testimony from a Congressional hearing held in New Jersey to examine violent crime against the elderly. Opening statements are presented from committee members Matthew J. Rinaldo, William J. Hughes, Christopher H. Smith, and Dan Mica. Four panels of witnesses testify: (1) two elderly victims of violent crime; (2) federal,…

  14. 78 FR 2711 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  15. 77 FR 56698 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  16. 77 FR 2603 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  17. 76 FR 59481 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  18. 77 FR 27835 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  19. 78 FR 66098 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for...

  20. 75 FR 22892 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  1. 75 FR 63255 - Air Traffic Procedures Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee Meeting AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  2. 76 FR 27168 - Air Traffic Procedures Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Federal Aviation Administration Air Traffic Procedures Advisory Committee AGENCY: Federal Aviation... Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification,...

  3. 77 FR 64997 - Advisory Committee on Childhood Lead Poisoning Prevention

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... HUMAN SERVICES Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning... scientific knowledge and technological developments and their practical implications for childhood lead poisoning prevention efforts. The committee also reviews and reports regularly on childhood lead...

  4. Food activities and identity maintenance in old age: a systematic review and meta-synthesis

    PubMed Central

    Plastow, Nicola Ann; Atwal, Anita; Gilhooly, Mary

    2015-01-01

    Objectives: Services provided to older people should be developed based on active ageing policies. Nutrition is one aspect of active ageing, but little is known about how food activities contribute to psychological well-being in later life. This is a systematic review of qualitative and quantitative research that answers the question ‘What is known about the relationship between food activities and the maintenance of identities in old age?’. Methods: We followed the preferred reporting items for systematic reviews and meta-analyses guidelines and used quality assessment parameters to complete a systematic review and narrative synthesis. Academic Search Premier, MEDLINE, CINAHL Plus, and PsycINFO databases were searched. Results: We initially identified 8016 articles, of which 167 full-text articles were screened for inclusion. Twenty-two articles were included in the review. There was moderate evidence from nine qualitative and two quantitative studies, of variable quality, that food activities contribute to the maintenance of women's gendered identities, the ethnic identities of men and women, and community identities. There was moderate evidence from 10 qualitative studies, of variable quality, that a change in food choice and deteriorating health changed food activity participation. These changes threatened identities. Most studies included both younger adults and older adults. Conclusion: In later life, there are many life experiences leading to change. Further research is needed to develop understanding of how identity and mental well-being are maintained, despite changes in everyday activities like cooking and eating. This may enable health care professionals to meet psychological needs alongside biological needs during nutritional interventions. PMID:25373998

  5. Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes.

    PubMed

    Janghorbani, Mohsen; Mansourian, Marjan; Hosseini, Elham

    2014-08-01

    The relation of early menarche with type 2 diabetes mellitus (T2DM) remains inconsistent across studies. The objective of this systematic review and meta-analysis of published population-based observational studies was to assess the association between age at menarche and T2DM risk. We searched online data bases through December 2013 and examined the reference lists of pertinent articles. Summary relative risks (RRs) with 95 % confidence intervals (CIs) were calculated with a random-effects model. A total of 14 effect estimates from 10 eligible studies (three cross-sectional and seven cohort studies) included 315,428 participants and 22,085 cases of T2DM. Compared with the highest or middle category, women in the lowest category of age at menarche had higher risk of T2DM [summary RR (95 % CI) 1.22 (1.17, 1.28)]. These results were consistent between studies that conducted in the United States and in Europe. The association between age at menarche and T2DM was slightly stronger for cohort than for cross-sectional studies. These findings strongly support an association between younger age at menarche and increased risk of T2DM. Age at menarche may help identify women with increased risk of developing T2DM. PMID:24671509

  6. Ageism and age discrimination in health care: Fact or fiction? A narrative review of the literature.

    PubMed

    Kydd, Angela; Fleming, Anne

    2015-08-01

    Ageism and age discrimination are terms used in best practice statements and in the literature to define negative attitudes towards older people and towards people because of their age (whether old or young). However, 'old age' is a nebulous concept with definitions ranging from the over 50s to the over 85s. In seeking to explore ageism and age discrimination within health care, this paper discusses the concept of 'old' and discusses the findings of a narrative review of the literature on these two concepts. Results show that negative attitudes have been perceived by users of health care services, but the reasons are not clear. Such attitudes are usually reported in acute health care settings, where targets and quick turnover are encouraged. Thus people, usually those with complex needs, who require longer periods of recuperation and rehabilitation following an episode of ill health, are troublesome to staff working in a system geared up for early discharges. This type of service user is usually over the age of 85. Recommendations from this paper include the need for acute frailty units, with well trained staff, where frail older people can be comprehensively assessed, receive timely and targeted care, followed by a supported discharge.

  7. Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

    PubMed

    Fernández, Óscar; Arnal-García, Carmen; Arroyo-González, Rafael; Brieva, Lluís; Calles-Hernández, M Carmen; Casanova-Estruch, Bonaventura; Comabella, Manuel; de las Heras, Virginia; García-Merino, Juan A; Hernández-Pérez, Miguel A; Izquierdo, Guillermo; Matas, Elisabet; Meca-Lallana, José E; Mendibe-Bilbao, María del Mar; Muñoz-García, Delicias; Olascoaga, Javier; Oreja-Guevara, Celia; Prieto, José M; Ramió-Torrentà, Lluís; Rodríguez-Antigüedad, Alfredo; Saiz, Albert; Téllez, Nieves; Villar, Luisa M; Tintoré, Mar

    2013-10-01

    The most significant data presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in France in October 2012, have been summarised in the fifth edition of the Post-ECTRIMS Experts Meeting, held in Madrid in October 2012. This led to the drafting of this review, which has been published in three parts. This third part of the Post-ECTRIMS review presents the findings from the latest studies conducted with disease-modifying treatments, more specifically with glatiramer acetate, laquinimod, ponesimod, BG-12, teriflunomide, daclizumab, natalizumab and secukinumab (AIN457). Likewise, we also address the reasons that justify the search for innovative treatments for multiple sclerosis, with antigen-specific therapy, cell therapy and therapy aimed at promoting remyelination being highlighted among other future therapeutic strategies. Access to new pharmacological agents and the complexity of the therapy of multiple sclerosis in the future will require new design strategies and directions in clinical trials, including the use of surrogate markers, new statistical applications, superiority, inferiority or equivalence clinical trials and adaptable designs.

  8. Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

    PubMed

    Fernández, Óscar; Álvarez-Cermeño, José C; Arnal-García, Carmen; Arroyo-González, Rafael; Brieva, Lluís; Calles-Hernández, M Carmen; Casanova-Estruch, Bonaventura; Comabella, Manuel; García-Merino, Juan A; Izquierdo, Guillermo; Meca-Lallana, José E; Mendibe-Bilbao, María del Mar; Muñoz-García, Delicias; Olascoaga, Javier; Oliva-Nacarino, Pedro; Oreja-Guevara, Celia; Prieto, José M; Ramió-Torrentà, Lluís; Romero-Pinel, Lucía; Saiz, Albert; Rodríguez-Antigüedad, Alfredo; Grupo Post-ECTRIMS

    2014-10-16

    The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting held in Madrid in October 2013, resulting in this review, which is being published in three parts. This third part of the Post-ECTRIMS review discusses the effects of immunomodulatory therapy on the natural history of multiple sclerosis, with special attention to the assessment of long-term effects and the use of historical controls as an alternative to randomised trials compared with placebo. This article contains possible future therapeutic strategies to be tested in experimental models and discusses clinical trials that are underway and future treatments. It also summarises the results of recent studies of disease-modifying treatments and developments in symptom management. Briefly, on the horizon are many drugs with different mechanisms of action, although new strategies and treatment algorithms are needed, as are new biomarkers and assessment measures of secondary progression and long-term records to assess safety. As for the symptomatic treatment of the disease, the proposal is a personalised treatment plan and a multidisciplinary approach to improve the quality of life of patients.

  9. [Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II)].

    PubMed

    Fernández, Óscar; Álvarez-Cermeño, José C; Arnal-García, Carmen; Arroyo-González, Rafael; Brieva, Lluís; Calles-Hernández, M Carmen; Casanova-Estruch, Bonaventura; Comabella, Manuel; García-Merino, Juan A; Izquierdo, Guillermo; Meca-Lallana, José E; Mendibe-Bilbao, María del Mar; Muñoz-García, Delicias; Olascoaga, Javier; Oliva-Nacarino, Pedro; Oreja-Guevara, Celia; Prieto, José M; Ramió-Torrentà, Lluís; Romero-Pinel, Lucía; Saiz, Albert; Rodríguez-Antigüedad, Alfredo

    2014-10-01

    The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, which is being published in three parts. This second part of the Post-ECTRIMS review focuses on diagnostic imaging and differential diagnosis, the clinical and paraclinical monitoring of neurodegeneration, progression and disability, and functional imaging and neural connectivity. It is clear that conventional multiple sclerosis sequences remain essential for the diagnosis, differential diagnosis and disease monitoring, that new MRI techniques help to assess the neurodegenerative process, and that some of the new sequences are more specific to neuroaxonal injury. Very high field magnetic resonance imaging allows better understanding of the lesion load, distribution and heterogeneity of the lesions, and positron emission tomography studies offer new insight into the patho-physiology of the disease. Functional imaging and neural connectivity studies show that there is cortical reorganisation in multiple sclerosis, whose equilibrium with structural damage is responsible for the impairment.

  10. Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

    PubMed

    Fernández, Óscar; Arnal-García, Carmen; Arroyo-González, Rafael; Brieva, Lluís; Calles-Hernández, M Carmen; Casanova-Estruch, Bonaventura; Comabella, Manuel; de las Heras, Virginia; García-Merino, Juan A; Hernández-Pérez, Miguel A; Izquierdo, Guillermo; Matas, Elisabet; Meca-Lallana, José E; Mendibe-Bilbao, María del Mar; Muñoz-García, Delicias; Olascoaga, Javier; Oreja-Guevara, Celia; Prieto, José M; Ramió-Torrentà, Lluís; Rodríguez-Antigüedad, Alfredo; Saiz, Albert; Téllez, Nieves; Villar, Luisa M; Tintoré, Mar

    2013-10-01

    The most significant data presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in France in October 2012, have been summarised in the fifth edition of the Post-ECTRIMS Experts Meeting, held in Madrid in October 2012. This led to the drafting of this review, which has been published in three parts. This third part of the Post-ECTRIMS review presents the findings from the latest studies conducted with disease-modifying treatments, more specifically with glatiramer acetate, laquinimod, ponesimod, BG-12, teriflunomide, daclizumab, natalizumab and secukinumab (AIN457). Likewise, we also address the reasons that justify the search for innovative treatments for multiple sclerosis, with antigen-specific therapy, cell therapy and therapy aimed at promoting remyelination being highlighted among other future therapeutic strategies. Access to new pharmacological agents and the complexity of the therapy of multiple sclerosis in the future will require new design strategies and directions in clinical trials, including the use of surrogate markers, new statistical applications, superiority, inferiority or equivalence clinical trials and adaptable designs. PMID:24052443

  11. Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).

    PubMed

    Fernandez, O; Alvarez-Cermeno, J C; Arnal-Garcia, C; Arroyo-Gonzalez, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; Garcia-Merino, J A; Izquierdo, G; Meca-Lallana, J E; Mendibe-Bilbao, M M; Munoz-Garcia, D; Olascoaga, J; Oliva-Nacarino, P; Oreja-Guevara, C; Prieto, J M; Ramio-Torrenta, Ll; Romero-Pinel, L; Saiz, A; Rodriguez-Antiguedad, A; Grupo Post-Ectrims, Grupo Post-Ectrims

    2014-09-16

    The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, to be published in three parts. This first part of the Post-ECTRIMS review presents an update on gender differences in multiple sclerosis (MS) as well as new evidence on the impact of sex hormones on the disease. We should consider that there is still much to discover with regard to the genetic components of the disease. Similarly, possible infections and lifestyle habits are added as triggers of the known environmental risk factors for MS. The interaction between genetics and the environment has been increasingly implicated as a cause of susceptibility to MS. With regard to the mechanisms of inflammation, axo-glial proteins, instead of myelin proteins, may be the early antigenic targets, and B cells have been implicated in the production of cytokines toxic to oligodendrocytes. Chitinase 3-like 1 (CHI3L1) is validated as a prognostic marker of conversion to MS, and immunoglobulin M oligoclonal bands and L-selectin could be incorporated as possible measures of the risk stratification strategy in patients treated with natalizumab.

  12. The evolution of aging phenotypes in snakes: a review and synthesis with new data

    PubMed Central

    2008-01-01

    Reptiles are underutilized vertebrate models in the study of the evolution and persistence of senescence. Their unique physiology, indeterminate growth, and increasing fecundity across the adult female lifespan motivate the study of how physiology at the mechanistic level, life history at the organismal level, and natural selection at the evolutionary timescale define lifespan in this diverse taxonomic group. Reviewed here are, first, comparative results of cellular metabolic studies conducted across a range of colubrid snake species with variable lifespan. New results on the efficiency of DNA repair in these species are synthesized with the cellular studies. Second, detailed studies of the ecology, life history, and cellular physiology are reviewed for one colubrid species with either short or long lifespan (Thamnophis elegans). New results on the rate of telomere shortening with age in this species are synthesized with previous research. The comparative and intraspecific studies both yield results that species with longer lifespans have underlying cellular physiologies support the free-radical/repair mechanistic hypothesis for aging. As well, both underscore the importance of mortality environment for the evolution of aging rate. PMID:19424866

  13. The Development Committee. Effective Committees. Board Basics.

    ERIC Educational Resources Information Center

    Evans, Gary

    1997-01-01

    A college or university governing board's development committee (or foundation board in a public institution) has both oversight of and broad responsibility for institutional fund-raising activities. Committee members have an additional role that colleagues on other committees do not--active participation in fund-raising. The committee sets goals,…

  14. On the particular vulnerability of face recognition to aging: a review of three hypotheses

    PubMed Central

    Boutet, Isabelle; Taler, Vanessa; Collin, Charles A.

    2015-01-01

    Age-related face recognition deficits are characterized by high false alarms to unfamiliar faces, are not as pronounced for other complex stimuli, and are only partially related to general age-related impairments in cognition. This paper reviews some of the underlying processes likely to be implicated in theses deficits by focusing on areas where contradictions abound as a means to highlight avenues for future research. Research pertaining to the three following hypotheses is presented: (i) perceptual deterioration, (ii) encoding of configural information, and (iii) difficulties in recollecting contextual information. The evidence surveyed provides support for the idea that all three factors are likely to contribute, under certain conditions, to the deficits in face recognition seen in older adults. We discuss how these different factors might interact in the context of a generic framework of the different stages implicated in face recognition. Several suggestions for future investigations are outlined. PMID:26347670

  15. Skin infections in young people (aged 14-18 years): an integrative review.

    PubMed

    Lambe, Catherine I; Hoare, Karen J

    2014-06-01

    Skin infections are a major cause of preventable hospitalization, with young people being particularly susceptible. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection typically presents as skin infection. CA-MRSA infection rates have increased rapidly in the past decade. Exploration of literature specific to young people aged 14-18 years is therefore timely. Integrative review using the methods described by Whittemore and Knafl was undertaken. Electronic databases of Medline, CINAHL, Scopus, Cochrane Database of Systematic Reviews, and Google databases were searched for English-language articles published after 1990. Twenty primary studies were included and the findings are reported here. Data analysis revealed factors influencing skin infections in young people may be host-, transmission-, or pathogen-specific. Strategies to address host and transmission factors may be effective in controlling skin infection rates in young people. PMID:23945044

  16. A scoping review of anorexia of aging correlates and their relevance to population health interventions.

    PubMed

    Roy, Mathieu; Gaudreau, Pierrette; Payette, Hélène

    2016-10-01

    Anorexia of aging (AA, i.e., loss of appetite and/or reduction of food intake with aging) is an important public health issue. It leads to unintentional weight loss, which is an independent risk factor for morbidity and mortality among seniors. AA has mainly been studied from a biological perspective and regarded as a normal physiological consequence of aging, rather than a negative health outcome with underlying determinants. Some potentially modifiable correlates have however been found to be associated with this geriatric condition. Here, we conducted a scoping review of the literature to: 1) identify AA correlates, and 2) discuss their relevance to population health interventions. Our results indicate two main categories of AA correlates, namely, physiopathological and non-physiopathological. The first category relates to physiological dysfunctions, pathologies involving (or culminating in) biomarker dysregulation, and polypharmacy. These correlates are difficult to modify, especially through population health interventions. The second category, which contains fewer correlates, includes potentially modifiable public health targets, such as food-related properties, psychological, sociocultural, and environmental issues. We conclude that there are several AA correlates. Some of them are modifiable and could be targeted for development and implementation as appropriate population health interventions to prevent appetite loss and promote maintenance of adequate food intake in aging.

  17. Nuclear and chromatin reorganization during cell senescence and aging - a mini-review.

    PubMed

    Shin, Dong-Myung; Kucia, Magda; Ratajczak, Mariusz Z

    2011-01-01

    Genetic material in the nucleus governs mechanisms related to cell proliferation, differentiation, and function. Thus, senescence and aging are directly tied to the change of nuclear function and structure. The most important mechanisms that affect cell senescence are: (i) telomere shortening; (ii) environmental stress-mediated accumulation of DNA mutations, and (iii) the intrinsically encoded biological clock that dictates lifespan events of any particular cell type. Overall, these changes lead to modification of the expression of genes that are responsible for: (i) organization of the nuclear structure; (ii) integrity of transcriptionally inactive heterochromatin, and (iii) epigenetic modification of chromosomes due to DNA methylation and/or histone modifications. These aging-related nuclear alterations do not only affect somatic cells. More importantly, they affect stem cells, which are responsible for proper tissue rejuvenation. In this review, we focus on epigenetic changes in the chromatin structure and their impact on the biology and function of adult cells as they age. We will also address aging-related changes in a compartment of the most primitive pluripotent stem cells that were recently identified by our team and named 'very small embryonic/epiblast-like stem cells'. PMID:20134149

  18. A scoping review of anorexia of aging correlates and their relevance to population health interventions.

    PubMed

    Roy, Mathieu; Gaudreau, Pierrette; Payette, Hélène

    2016-10-01

    Anorexia of aging (AA, i.e., loss of appetite and/or reduction of food intake with aging) is an important public health issue. It leads to unintentional weight loss, which is an independent risk factor for morbidity and mortality among seniors. AA has mainly been studied from a biological perspective and regarded as a normal physiological consequence of aging, rather than a negative health outcome with underlying determinants. Some potentially modifiable correlates have however been found to be associated with this geriatric condition. Here, we conducted a scoping review of the literature to: 1) identify AA correlates, and 2) discuss their relevance to population health interventions. Our results indicate two main categories of AA correlates, namely, physiopathological and non-physiopathological. The first category relates to physiological dysfunctions, pathologies involving (or culminating in) biomarker dysregulation, and polypharmacy. These correlates are difficult to modify, especially through population health interventions. The second category, which contains fewer correlates, includes potentially modifiable public health targets, such as food-related properties, psychological, sociocultural, and environmental issues. We conclude that there are several AA correlates. Some of them are modifiable and could be targeted for development and implementation as appropriate population health interventions to prevent appetite loss and promote maintenance of adequate food intake in aging. PMID:27374898

  19. A systematic review of age, sex, ethnicity, and race as predictors of violent recidivism.

    PubMed

    Piquero, Alex R; Jennings, Wesley G; Diamond, Brie; Reingle, Jennifer M

    2015-01-01

    Recidivism of released prisoners, especially violent recidivism, is an important policy issue. Equally important is an understanding of how demographic risk factors may act as moderators of recidivism. Knowledge of such relationships is important in developing a deeper theoretical understanding of the risk of recidivism as well as identifying points of intervention that may need to be re-oriented to reduce recidivism. The present study conducts a meta-analytic review of the violent recidivism literature focusing on the role of several demographic risk factors. Findings show that age, sex, and race (Whites) were significantly related to violent recidivism. Implications and directions for future research are identified.

  20. Genetic variants in the complement system predisposing to age-related macular degeneration: a review.

    PubMed

    Schramm, Elizabeth C; Clark, Simon J; Triebwasser, Michael P; Raychaudhuri, Soumya; Seddon, Johanna M; Atkinson, John P

    2014-10-01

    Age-related macular degeneration (AMD) is a major cause of visual impairment in the western world. It is characterized by the presence of lipoproteinaceous deposits (drusen) in the inner layers of the retina. Immunohistochemistry studies identified deposition of complement proteins in the drusen as well as in the choroid. In the last decade, genetic studies have linked both common and rare variants in genes of the complement system to increased risk of development of AMD. Here, we review the variants described to date and discuss the functional implications of dysregulation of the alternative pathway of complement in AMD.

  1. Initial Report of the Cancer PROMIS Supplement Sexual Function Committee: Review of Sexual Function Measures and Domains Used in Oncology

    PubMed Central

    Jeffery, Diana D.; Tzeng, Janice P.; Keefe, Francis J.; Porter, Laura S.; Hahn, Elizabeth A.; Flynn, Kathryn E.; Reeve, Bryce B.; Weinfurt, Kevin P.

    2009-01-01

    Objective This report describes initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function domain group (CaPS-SF), part of the National Institutes of Health (NIH) Roadmap Initiative to develop brief questionnaires or individually-tailored assessments of quality of life domains. Our literature review of sexual function measures used in cancer populations, and descriptions of domains found in those measures, is presented. Methods Using a consensus-driven approach, an electronic bibliographic search was conducted for articles published 1991-2007, yielding 486 articles for in-depth review. Results A total of 257 articles reported the administration of a psychometrically evaluated sexual function measure to individuals diagnosed with cancer. Apart from the UCLA Prostate Cancer Index, the International Index of Erectile Function, and the Female Sexual Function Index, the 31 identified measures have not been widely tested in cancer populations. Most measures were multidimensional and included domains related to the sexual response cycle and to general sexual satisfaction. Conclusions Our review supports the need for a flexible, psychometrically robust measure of sexual function for use in oncology settings and strongly justifies the development of the PROMIS-SF instrument. After PROMIS-SF is publicly available, cancer clinicians and researchers will have another measure to assess patient-reported sexual function outcomes in addition to the few legacy measures identified through our review. PMID:19195044

  2. Children's Health Insurance: Inspector General Reviews Should Be Expanded To Further Inform the Congress. Report to Congressional Committees.

    ERIC Educational Resources Information Center

    Allen, Kathryn G.

    This report reviews work by the Department of Health and Human Services Office of Inspector General (OIG), which evaluated the State Children's Health Insurance Program (SCHIP), including whether children are being enrolled inappropriately in SCHIP rather than in Medicaid, and states' progress in reducing the number of uninsured children. This…

  3. Reorganization of brain networks in aging: a review of functional connectivity studies

    PubMed Central

    Sala-Llonch, Roser; Bartrés-Faz, David; Junqué, Carme

    2015-01-01

    Healthy aging (HA) is associated with certain declines in cognitive functions, even in individuals that are free of any process of degenerative illness. Functional magnetic resonance imaging (fMRI) has been widely used in order to link this age-related cognitive decline with patterns of altered brain function. A consistent finding in the fMRI literature is that healthy old adults present higher activity levels in some brain regions during the performance of cognitive tasks. This finding is usually interpreted as a compensatory mechanism. More recent approaches have focused on the study of functional connectivity, mainly derived from resting state fMRI, and have concluded that the higher levels of activity coexist with disrupted connectivity. In this review, we aim to provide a state-of-the-art description of the usefulness and the interpretations of functional brain connectivity in the context of HA. We first give a background that includes some basic aspects and methodological issues regarding functional connectivity. We summarize the main findings and the cognitive models that have been derived from task-activity studies, and we then review the findings provided by resting-state functional connectivity in HA. Finally, we suggest some future directions in this field of research. A common finding of the studies included is that older subjects present reduced functional connectivity compared to young adults. This reduced connectivity affects the main brain networks and explains age-related cognitive alterations. Remarkably, the default mode network appears as a highly compromised system in HA. Overall, the scenario given by both activity and connectivity studies also suggests that the trajectory of changes during task may differ from those observed during resting-state. We propose that the use of complex modeling approaches studying effective connectivity may help to understand context-dependent functional reorganizations in the aging process. PMID:26052298

  4. Interventions to Increase Physical Activity in Children Aged 2-5 Years: A Systematic Review.

    PubMed

    Ling, Jiying; Robbins, Lorraine B; Wen, Fujun; Peng, Wei

    2015-08-01

    Comprehensive evaluation of prior interventions designed to increase preschoolers' physical activity is lacking. This systematic review aimed to examine the effect of interventions on objectively measured physical activity in children aged 2-5 years. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. In May 2014, we searched PubMed, CINAHL, PsycINFO, ERIC, SPORTDiscus, Cochrane, and Embase. Two reviewers independently identified and appraised the studies. Twenty-four articles describing 23 independent studies and 20 unique interventions met inclusion criteria. Of the 8 interventions resulting in a significant effect in objectively measured physical activity, all were center-based and included a structured physical activity component, 6 included multiple components, 5 integrated theories or models, and 4 actively involved parents. Seven of the 8 were randomized controlled trials. Due to the heterogeneity of the study designs, physical activity measures, and interventions, drawing definitive conclusions was difficult. Although the overall intervention effect was less than optimal, the review indicated that theory-driven, multicomponent interventions including a structured physical activity component and targeting both parents and their children may be a promising approach for increasing preschoolers' physical activity and warrant continued investigation using rigorous designs to identify those that are most effective.

  5. 76 FR 5160 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of intent to renew charter. SUMMARY: In... in the Digital Age (``Diversity Committee''). ADDRESSES: A copy of the charter is available at...

  6. Esthesioneuroblastoma in pediatric and adolescent age. A report from the TREP project in cooperation with the Italian Neuroblastoma and Soft Tissue Sarcoma Committees

    PubMed Central

    2012-01-01

    Background Esthesioneuroblastoma (ENB) is a rare, aggressive tumor with no established treatment in children. We analyzed a series of pediatric ENB patients with the aim of improving our knowledge of this disease. Methods 9 patients (6 males; age 0.9-18 years, median 9.9) were identified by searching the AIEOP (Italian Association of Pediatric Hematology and Oncology) registry and the national databases of rare tumors, soft tissue sarcomas (STS) and neuroblastomas. The data on the cases included in STS treatment protocols were collected prospectively and histology was centrally reviewed; the data and histology concerning the other children were reviewed for the purpose of this analysis. Results All tumors occurred in the sinonasal region with bone erosion (7 patients) and intracranial (4) or intraorbital (4) extension. Three patients were in Kadish stage B, and 6 in stage C. Complete tumor resection was very difficult to achieve, but adding chemotherapy and radiotherapy enabled tumor control in 8 patients. Response to chemotherapy was evident in 5/7 evaluable cases. Radiotherapy (48.5-60 Gy) was delivered in all children but one, due to early disease progression. With a median follow-up of 13.4 years (range 9.2-22.9), 7 patients are alive in 1st and one in 2nd complete remission. All surviving patients developed treatment-related sequelae, the most frequent being endocrine dysfunctions (4 patients) and craniofacial growth impairments (4 patients). Conclusions Our findings confirm that ENB in children has an aggressive presentation, but multimodal therapy can cure most patients. Our results are encouraging but future strategies must optimize treatment in terms of survival and related morbidities. PMID:22443159

  7. Elderly cancer patients' psychopathology: a systematic review: aging and mental health.

    PubMed

    Parpa, Efi; Tsilika, Eleni; Gennimata, Vassiliki; Mystakidou, Kyriaki

    2015-01-01

    This review of the literature on elderly cancer patients and their psychiatric disorders was undertaken to determine the extent of the problem. It consists of articles with elderly cancer patients. Keyword terms included "cancer", "elderly", "aging", "geriatric", "psychiatric disorders", "psychiatric symptoms", "psychological problems", "aged >60 years", "sucidal ideation, geriatric, cancer", "suicide geriatric cancer". We conducted searches on the following databases: PubMed; PsychINFO (1980-2013); finally, 102 publications were suitable for the current review. Depression in elderly cancer patients is the most common disorder in elderly cancer patients associated with disability, morbidity and mortality. Anxiety disorders may be less frequent in geriatric patients; however, it seemed to be a major problem in late life. Psychiatric disorders are common in geriatric patients with cancer especially at advanced stages of the disease. In addition, health care professionals can help provide treatment and emotional support. Future research should aim to provide data about the real prevalence and severity of psychiatric disorders in elderly patients with cancer, for the improvement of patients' quality of life and their caregivers.

  8. Effects of Testosterone Therapy on Cognitive Function in Aging: A Systematic Review.

    PubMed

    Hua, Jeremy T; Hildreth, Kerry L; Pelak, Victoria S

    2016-09-01

    Endogenous testosterone in the aging man has been scrutinized extensively in regard to its effects on performance in many cognitive domains, especially verbal fluency, visuospatial and visuoperceptual abilities, memory, and executive function. Studies of testosterone supplementation have sought to identify potential cognitive improvements in men with and without baseline cognitive impairment, and have had a wide range of results. The variability in outcomes is likely related, in part, to the lack of consensus on methods for testosterone measurement and supplementation and, in part, to the disparate measures of cognitive function used in randomized controlled studies. Despite the limitations imposed by such inconsistent methods, promising associations have been found between cognition and testosterone supplementation in both eugonadal men and men with low testosterone levels, with and without baseline cognitive dysfunction. This systematic review highlights the cognitive measures used in and the outcomes of existing studies of testosterone and cognition in aging men. The review suggests that larger studies and a more standardized approach to assessment will be needed before we can fully understand and realize sustained benefits from testosterone supplementation in the elderly male population, particularly given the substantial increase in testosterone supplementation in clinical practice. PMID:27662450

  9. 36 CFR 1151.6 - Committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... review all committee charters. (2) Chair. The Vice-Chair of the Board shall serve as Chair of the... 1151.6 Parks, Forests, and Public Property ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD BYLAWS § 1151.6 Committees. (a) Executive Committee—(1) Establishment. The Board shall have an...

  10. 76 FR 63600 - Ashley Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Ashley Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ashley Resource Advisory Committee will conduct a meeting to review project status...

  11. The Role of a Model's Age for Young Children's Imitation: A Research Review

    ERIC Educational Resources Information Center

    Zmyj, Norbert; Seehagen, Sabine

    2013-01-01

    The influence of a model's age on young children's behaviour has been a subject of considerable debate among developmental theorists. Despite the recent surge of interest, controversy remains about the nature of peer influence in early life. This article reviews studies that investigated the influence of a model's age on young…

  12. Beset by Obstacles: A Review of Australian Policy Development to Support Ageing in Place for People with Intellectual Disability

    ERIC Educational Resources Information Center

    Bigby, Christine

    2008-01-01

    Background: Australian government policy regards people with intellectual disability (ID) as citizens with equal rights, which means that they should have access to the same opportunities as the wider community. Ageing in place is central to aged care policy in Australia for the general population. Method: This paper reviews policy to support the…

  13. Prevalence, Type, Distribution, and Severity of Cerebral Palsy in Relation to Gestational Age: A Meta-Analytic Review

    ERIC Educational Resources Information Center

    Himpens, E.; Van den Broeck, C.; Oostra, A.; Calders, P.; Vanhaesebrouck, P.

    2008-01-01

    The aim of this review is to determine the relationship between gestational age (GA) and prevalence, type, distribution, and severity of cerebral palsy (CP). Epidemiological studies with cohorts expressed by GA were assessed. A comprehensive meta-analysis and meta-regression was performed on four fetal age categories. Studies of children with CP…

  14. A review of new insights on the association between hearing loss and cognitive decline in ageing.

    PubMed

    Fortunato, S; Forli, F; Guglielmi, V; De Corso, E; Paludetti, G; Berrettini, S; Fetoni, A R

    2016-06-01

    Age-related hearing loss (ARHL) has a multifactorial pathogenesis and it is an inevitable hearing impairment associated with reduction of communicative skills related to ageing. Increasing evidence has linked ARHL to more rapid progression of cognitive decline and incidental dementia. Many aspects of daily living of elderly people have been associated to hearing abilities, showing that hearing loss (HL) affects the quality of life, social relationships, motor skills, psychological aspects and function and morphology in specific brain areas. Epidemiological and clinical studies confirm the assumption of a relationship between these conditions. However, the mechanisms are still unclear and are reviewed herein. Long-term hearing deprivation of auditory inputs can impact cognitive performance by decreasing the quality of communication leading to social isolation and depression and facilitate dementia. On the contrary, the limited cognitive skills may reduce the cognitive resources available for auditory perception, increasing the effects of HL. In addition, hearing loss and cognitive decline may reflect a 'common cause' on the auditory pathway and brain. In fact, some pathogenetic factors are recongised in common microvascular disease factors such as diabetes, atherosclerosis and hypertension. Interdisciplinary efforts to investigate and address HL in the context of brain and cognitive ageing are needed. Surprisingly, few studies have been adressed on the effectiveness of hearing aids in changing the natural history of cognitive decline. Effective interventions with hearing aids or cochlear implant may improve social and emotional function, communication, cognitive function and positively impact quality of life. The aim of this review is to overview new insights on this challenging topic and provide new ideas for future research.

  15. Systematic review of sedentary behaviour and health indicators in school-aged children and youth

    PubMed Central

    2011-01-01

    Accumulating evidence suggests that, independent of physical activity levels, sedentary behaviours are associated with increased risk of cardio-metabolic disease, all-cause mortality, and a variety of physiological and psychological problems. Therefore, the purpose of this systematic review is to determine the relationship between sedentary behaviour and health indicators in school-aged children and youth aged 5-17 years. Online databases (MEDLINE, EMBASE and PsycINFO), personal libraries and government documents were searched for relevant studies examining time spent engaging in sedentary behaviours and six specific health indicators (body composition, fitness, metabolic syndrome and cardiovascular disease, self-esteem, pro-social behaviour and academic achievement). 232 studies including 983,840 participants met inclusion criteria and were included in the review. Television (TV) watching was the most common measure of sedentary behaviour and body composition was the most common outcome measure. Qualitative analysis of all studies revealed a dose-response relation between increased sedentary behaviour and unfavourable health outcomes. Watching TV for more than 2 hours per day was associated with unfavourable body composition, decreased fitness, lowered scores for self-esteem and pro-social behaviour and decreased academic achievement. Meta-analysis was completed for randomized controlled studies that aimed to reduce sedentary time and reported change in body mass index (BMI) as their primary outcome. In this regard, a meta-analysis revealed an overall significant effect of -0.81 (95% CI of -1.44 to -0.17, p = 0.01) indicating an overall decrease in mean BMI associated with the interventions. There is a large body of evidence from all study designs which suggests that decreasing any type of sedentary time is associated with lower health risk in youth aged 5-17 years. In particular, the evidence suggests that daily TV viewing in excess of 2 hours is associated with

  16. A review of new insights on the association between hearing loss and cognitive decline in ageing.

    PubMed

    Fortunato, S; Forli, F; Guglielmi, V; De Corso, E; Paludetti, G; Berrettini, S; Fetoni, A R

    2016-06-01

    Age-related hearing loss (ARHL) has a multifactorial pathogenesis and it is an inevitable hearing impairment associated with reduction of communicative skills related to ageing. Increasing evidence has linked ARHL to more rapid progression of cognitive decline and incidental dementia. Many aspects of daily living of elderly people have been associated to hearing abilities, showing that hearing loss (HL) affects the quality of life, social relationships, motor skills, psychological aspects and function and morphology in specific brain areas. Epidemiological and clinical studies confirm the assumption of a relationship between these conditions. However, the mechanisms are still unclear and are reviewed herein. Long-term hearing deprivation of auditory inputs can impact cognitive performance by decreasing the quality of communication leading to social isolation and depression and facilitate dementia. On the contrary, the limited cognitive skills may reduce the cognitive resources available for auditory perception, increasing the effects of HL. In addition, hearing loss and cognitive decline may reflect a 'common cause' on the auditory pathway and brain. In fact, some pathogenetic factors are recongised in common microvascular disease factors such as diabetes, atherosclerosis and hypertension. Interdisciplinary efforts to investigate and address HL in the context of brain and cognitive ageing are needed. Surprisingly, few studies have been adressed on the effectiveness of hearing aids in changing the natural history of cognitive decline. Effective interventions with hearing aids or cochlear implant may improve social and emotional function, communication, cognitive function and positively impact quality of life. The aim of this review is to overview new insights on this challenging topic and provide new ideas for future research. PMID:27214827

  17. Evidence-Based Systematic Review: Effects of Different Service Delivery Models on Communication Outcomes for Elementary School-Age Children

    ERIC Educational Resources Information Center

    Cirrin, Frank M.; Schooling, Tracy L.; Nelson, Nickola W.; Diehl, Sylvia F.; Flynn, Perry F.; Staskowski, Maureen; Torrey, T. Zoann; Adamczyk, Deborah F.

    2010-01-01

    Purpose: The purpose of this investigation was to conduct an evidence-based systematic review (EBSR) of peer-reviewed articles from the last 30 years about the effect of different service delivery models on speech-language intervention outcomes for elementary school-age students. Method: A computer search of electronic databases was conducted to…

  18. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.

    PubMed

    Lehert, P; Villaseca, P; Hogervorst, E; Maki, P M; Henderson, V W

    2015-10-01

    A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. We identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging. For ten of these, we used PubMed databases for a systematic review of long-duration (at least 6 months), randomized, controlled trials in midlife and older adults without dementia or mild cognitive impairment with objective measures of neuropsychological performance. Using network meta-analysis, we performed a quantitative synthesis for global cognition (primary outcome) and episodic memory (secondary outcome). Of 1038 publications identified by our search strategy, 24 eligible trials were included in the network meta-analysis. Results suggested that the Mediterranean diet supplemented by olive oil and tai chi exercise may improve global cognition, and the Mediterranean diet plus olive oil and soy isoflavone supplements may improve memory. Effect sizes were no more than small (standardized mean differences 0.11-0.22). Cognitive training may have cognitive benefit as well. Most individually modifiable risk factors have not yet been adequately studied. We conclude that some interventions that can be self-initiated by healthy midlife and older adults may ameliorate cognitive aging. PMID:26361790

  19. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.

    PubMed

    Lehert, P; Villaseca, P; Hogervorst, E; Maki, P M; Henderson, V W

    2015-10-01

    A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. We identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging. For ten of these, we used PubMed databases for a systematic review of long-duration (at least 6 months), randomized, controlled trials in midlife and older adults without dementia or mild cognitive impairment with objective measures of neuropsychological performance. Using network meta-analysis, we performed a quantitative synthesis for global cognition (primary outcome) and episodic memory (secondary outcome). Of 1038 publications identified by our search strategy, 24 eligible trials were included in the network meta-analysis. Results suggested that the Mediterranean diet supplemented by olive oil and tai chi exercise may improve global cognition, and the Mediterranean diet plus olive oil and soy isoflavone supplements may improve memory. Effect sizes were no more than small (standardized mean differences 0.11-0.22). Cognitive training may have cognitive benefit as well. Most individually modifiable risk factors have not yet been adequately studied. We conclude that some interventions that can be self-initiated by healthy midlife and older adults may ameliorate cognitive aging.

  20. Highway crash rates and age-related driver limitations: Literature review and evaluation of data bases

    SciTech Connect

    Hu, P.S.; Young, J.R.; Lu, An

    1993-08-01

    American society is undergoing a major demographic transformation that is resulting in a larger proportion of older individuals in the population. Moreover, recent travel surveys show that an increasing number of older individuals are licensed to drive and that they drive more than their same age cohort a decade ago. However, they continue to take shorter trips than younger drivers and they avoid driving during congested hours. This recent demographic transformation in our society, the graying of America, coupled with the increasing mobility of the older population impose a serious highway safety issue that cannot be overlooked. Some of the major concerns are the identification of ``high-risk`` older drivers and the establishment of licensing guidelines and procedures that are based on conclusive scientific evidence. Oak Ridge National Laboratory`s (ORNL) objectives in this project can be characterized by the following tasks: Review and evaluate the 1980 American Association of Motor Vehicle Administrators (AAMVA) and National Highway Traffic Safety Administration (NHTSA) licensing guidelines. Determine whether the license restriction recommended in the 1980 AAMVA and NHTSA guidelines was based on scientific evidence or on judgement of medical advisors. Identify in the scientific literature any medical conditions which are found to be highly associated with highway crashes, and which are not mentioned in the 1980 guidelines. Summarize States` current licensing practices for drivers with age-related physical and mental limitations. Identify potential data sources to establish conclusive evidence on age-related functional impairments and highway crashes.

  1. Independent ethical review of studies involving personal medical records. Report of a working group to the Royal College of Physicians Committee on Ethical Issues in Medicine.

    PubMed

    1994-01-01

    There is a duty to use available information for the general good where this can be done without detriment. It is, in principle, ethically acceptable to use personal medical records without approaching or involving the patients concerned, provided that confidentiality and anonymity are preserved; such use does not require independent ethical approval provided that confidentiality is assured and subject to safeguards described below. Epidemiologists have a special interest in the use of personal medical records in their work (in this context the use of health-related registers and existing biological samples may be included), though access to such data involves professional staff in all medical specialties, not only those in epidemiology. The following guidance is based on a report of a working group (which included non-medical members) to the Royal College of Physicians Committee on Ethical Issues in Medicine. Activities such as medical audit, epidemiological surveillance, inquiries designed to establish indices of morbidity and mortality and outbreak investigations all constitute medical practice and as such do not require independent ethical review. Research involving access to medical records, health-related registers, or existing biological samples only, without direct patient involvement, requires neither explicit individual patient consent nor independent ethical review provided that: a) explicit consent to access a person's records is obtained either from official custodians of the records (who have a duty to satisfy themselves as to the bona fides and competence of the investigator) or from the patient's clinician: the decision to access personal medical information should not be left to the sole discretion of the investigator.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7807434

  2. 78 FR 28237 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Beach, CA 90802, which was published in the Federal Register on May 3, 2013, 78 FR 26054. The dates of... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Clinical Aging Review Committee, June 12,...

  3. 78 FR 35041 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel SWAN. Date: June 27, 2013. Time: 9:30 a.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  4. 76 FR 23827 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Osteoarthritis. Date: June 8, 2011. Time: 9 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  5. 75 FR 18511 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Loan Repayment. Date: May 3, 2010. Time: 12 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  6. 78 FR 16273 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel. Date: April 1, 2013. Time: 12:00 p.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  7. 77 FR 74677 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Committee: National Institute on Aging Special Emphasis Panel; Cell Dependent and Independent Mechanism... applications. Place: National Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue...:00 p.m. to 4:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institute...

  8. Use of MenACWY-CRM vaccine in children aged 2 through 23 months at increased risk for meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2013.

    PubMed

    MacNeil, Jessica R; Rubin, Lorry; McNamara, Lucy; Briere, Elizabeth C; Clark, Thomas A; Cohn, Amanda C

    2014-06-20

    During its October 2013 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended use of a third meningococcal conjugate vaccine, MenACWY-CRM (Menveo, Novartis), as an additional option for vaccinating infants aged 2 through 23 months at increased risk for meningococcal disease. MenACWY-CRM is the first quadrivalent meningococcal conjugate vaccine licensed for use in children aged 2 through 8 months. MenACWY-D (Menactra, Sanofi Pasteur) is recommended for use in children aged 9 through 23 months who are at increased risk for meningococcal disease, and Hib-MenCY-TT (MenHibrix, GlaxoSmithKline) is recommended for use in children aged 6 weeks through 18 months at increased risk. This report summarizes information on MenACWY-CRM administration in infants and provides recommendations for vaccine use in infants aged 2 through 23 months who are at increased risk for meningococcal disease. Because the burden of meningococcal disease in infants is low in the United States and the majority of cases that do occur are caused by serogroup B, which is not included in any vaccine licensed in the United States, only those infants who are at increased risk for meningococcal disease are recommended to receive a meningococcal vaccine.

  9. The Buildings and Grounds Committee. Effective Committees. Board Basics.

    ERIC Educational Resources Information Center

    Flinn, Ronald T.

    1997-01-01

    The committee on buildings and grounds of a college or university governing board is charged with the broad responsibility for overseeing an institution's physical assets: land, buildings, and equipment. Specific tasks include ensuring the adequacy and condition of capital assets, developing and periodically reviewing policies, advocating for new…

  10. A review of creatine supplementation in age-related diseases: more than a supplement for athletes.

    PubMed

    Smith, Rachel N; Agharkar, Amruta S; Gonzales, Eric B

    2014-01-01

    Creatine is an endogenous compound synthesized from arginine, glycine and methionine. This dietary supplement can be acquired from food sources such as meat and fish, along with athlete supplement powders. Since the majority of creatine is stored in skeletal muscle, dietary creatine supplementation has traditionally been important for athletes and bodybuilders to increase the power, strength, and mass of the skeletal muscle. However, new uses for creatine have emerged suggesting that it may be important in preventing or delaying the onset of neurodegenerative diseases associated with aging. On average, 30% of muscle mass is lost by age 80, while muscular weakness remains a vital cause for loss of independence in the elderly population. In light of these new roles of creatine, the dietary supplement's usage has been studied to determine its efficacy in treating congestive heart failure, gyrate atrophy, insulin insensitivity, cancer, and high cholesterol. In relation to the brain, creatine has been shown to have antioxidant properties, reduce mental fatigue, protect the brain from neurotoxicity, and improve facets/components of neurological disorders like depression and bipolar disorder. The combination of these benefits has made creatine a leading candidate in the fight against age-related diseases, such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, long-term memory impairments associated with the progression of Alzheimer's disease, and stroke. In this review, we explore the normal mechanisms by which creatine is produced and its necessary physiology, while paying special attention to the importance of creatine supplementation in improving diseases and disorders associated with brain aging and outlining the clinical trials involving creatine to treat these diseases.

  11. The microbiome and disease: reviewing the links between the oral microbiome, aging, and Alzheimer's disease.

    PubMed

    Shoemark, Deborah K; Allen, Shelley J

    2015-01-01

    This review, gathered from diverse sources, shows how our microbiome influences health and ultimately how well we age. Evidence linking oral bacteria to Alzheimer's disease (AD) is discussed in the context of aging, drawing together data from epidemiological, experimental, genetic, and environmental studies. Immunosenescence results in increased bacterial load as cell-mediated and humoral immune responses wane. The innate immune system gradually takes over; contributing to the rise in circulating proinflammatory cytokines such as TNFα. Maintaining the integrity of the blood-brain barrier (BBB) against a backdrop of increasing bacterial load is important. Aging may favor the proliferation of anaerobes in the mouth eliciting a robust TNFα response from the oral epithelium. Prolonged exposure to high levels of circulating TNFα compromises the integrity of the BBB. Sensitive techniques now detect the "asymptomatic" presence of bacteria in areas previously thought to be sterile, providing new insights into the wider distribution of components of the microbiome. These "immune-tolerated" bacteria may slowly multiply elsewhere until they elicit a chronic inflammatory response; some are now considered causal in instances of atherosclerosis and back pain. Inflammatory processes have long been associated with AD. We propose for a subset of AD patients, aging favors the overgrowth of oral anaerobes established earlier in life provoking a pro-inflammatory innate response that weakens the BBB allowing bacteria to spread and quietly influence the pathogenesis of AD. Finally, we suggest that human polymorphisms considered alongside components of the microbiome may provide new avenues of research for the prevention and treatment of disease.

  12. Scientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment.

    PubMed

    Wood, Charles E; Hukkanen, Renee R; Sura, Radhakrishna; Jacobson-Kram, David; Nolte, Thomas; Odin, Marielle; Cohen, Samuel M

    2015-08-01

    Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified information on assay standards, reference values, targeted applications, study design issues, and quality control considerations for proliferation data. Here, we review issues in measuring cell proliferation indices, considerations for targeted studies, and applications within current risk assessment frameworks. As the regulatory environment moves toward more prospective evaluations based on quantitative pathway-based models, standardization of proliferation assays will become an increasingly important part of cancer risk assessment. To help address this development, we also discuss the potential role for proliferation data as a component of alternative carcinogenicity testing models. This information should improve consistency of cell proliferation methods and increase efficiency of targeted testing strategies. PMID:25903269

  13. Department of Energy Review of Laboratory Programs for Women Points-of-Contact Committee: Comparative Report, June 1995

    SciTech Connect

    McLane, V.; Layne, A.

    1995-06-01

    A survey of the DOE facilities was undertaken by the Points-of-Contact for the DOE Review of Laboratory Programs for Women in order to gather data to be used as a baseline against which to measure future progress. We plan to look at current programs already in place and evaluate them with a view to deciding which programs are most effective, and selecting model programs suitable for implementation at other facilities. The survey focused on four areas: 1) statistical data, 2) laboratory policy, 3) formal and informal programs which affect the quality of life in the work environment, and career development and advancement, and 4) educational programs. Although this report focuses on women, the problems discussed affect all DOE facility employees.

  14. Can psychosocial work conditions protect against age-related cognitive decline? Results from a systematic review.

    PubMed

    Nexø, Mette Andersen; Meng, Annette; Borg, Vilhelm

    2016-07-01

    According to the use it or lose it hypothesis, intellectually stimulating activities postpone age-related cognitive decline. A previous systematic review concluded that a high level of mental work demands and job control protected against cognitive decline. However, it did not distinguish between outcomes that were measured as cognitive function at one point in time or as cognitive decline. Our study aimed to systematically review which psychosocial working conditions were prospectively associated with high levels of cognitive function and/or changes in cognitive function over time. Articles were identified by a systematic literature search (MEDLINE, Web of Science (WOS), PsycNET, Occupational Safety and Health (OSH)). We included only studies with longitudinal designs examining the impact of psychosocial work conditions on outcomes defined as cognitive function or changes in cognitive function. Two independent reviewers compared title-abstract screenings, full-text screenings and quality assessment ratings. Eleven studies were included in the final synthesis and showed that high levels of mental work demands, occupational complexity or job control at one point in time were prospectively associated with higher levels of cognitive function in midlife or late life. However, the evidence to clarify whether these psychosocial factors also affected cognitive decline was insufficient, conflicting or weak. It remains speculative whether job control, job demands or occupational complexity can protect against cognitive decline. Future studies using methodological advancements can reveal whether workers gain more cognitive reserve in midlife and late life than the available evidence currently suggests. The public health implications of a previous review should thereby be redefined accordingly. PMID:27178844

  15. Can psychosocial work conditions protect against age-related cognitive decline? Results from a systematic review

    PubMed Central

    Nexø, Mette Andersen; Meng, Annette; Borg, Vilhelm

    2016-01-01

    According to the use it or lose it hypothesis, intellectually stimulating activities postpone age-related cognitive decline. A previous systematic review concluded that a high level of mental work demands and job control protected against cognitive decline. However, it did not distinguish between outcomes that were measured as cognitive function at one point in time or as cognitive decline. Our study aimed to systematically review which psychosocial working conditions were prospectively associated with high levels of cognitive function and/or changes in cognitive function over time. Articles were identified by a systematic literature search (MEDLINE, Web of Science (WOS), PsycNET, Occupational Safety and Health (OSH)). We included only studies with longitudinal designs examining the impact of psychosocial work conditions on outcomes defined as cognitive function or changes in cognitive function. Two independent reviewers compared title-abstract screenings, full-text screenings and quality assessment ratings. Eleven studies were included in the final synthesis and showed that high levels of mental work demands, occupational complexity or job control at one point in time were prospectively associated with higher levels of cognitive function in midlife or late life. However, the evidence to clarify whether these psychosocial factors also affected cognitive decline was insufficient, conflicting or weak. It remains speculative whether job control, job demands or occupational complexity can protect against cognitive decline. Future studies using methodological advancements can reveal whether workers gain more cognitive reserve in midlife and late life than the available evidence currently suggests. The public health implications of a previous review should thereby be redefined accordingly. PMID:27178844

  16. 75 FR 14564 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Farm Service Agency Dairy Industry Advisory Committee; Public Meeting AGENCY: Farm Service Agency, USDA..., the Farm Service Agency (FSA) announces a public meeting of the newly established Dairy Industry Advisory Committee (Dairy Committee) to review the current state of the dairy industry, discuss...

  17. 76 FR 4611 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... Farm Service Agency Dairy Industry Advisory Committee; Public Meeting AGENCY: Farm Service Agency, USDA..., the Farm Service Agency (FSA) announces a public meeting of the Dairy Industry Advisory Committee (Dairy Committee) to review and approve the final recommendations to the Secretary of Agriculture....

  18. 76 FR 8998 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... Farm Service Agency Dairy Industry Advisory Committee; Public Meeting AGENCY: Farm Service Agency, USDA..., the Farm Service Agency (FSA) announces a public meeting of the Dairy Industry Advisory Committee (Dairy Committee) to review and approve the final recommendations to the Secretary of Agriculture....

  19. 75 FR 12768 - Blood Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... will be closed to the public. Name of Committee: Blood Products Advisory Committee. General Function of... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... Hematology, Office of Blood Research and Review, CBER, FDA. FDA intends to make background material...

  20. 77 FR 29667 - Blood Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... will be closed to the public. Name of Committee: Blood Products Advisory Committee. General Function of... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research,...

  1. 75 FR 52714 - Wrangell-Petersburg Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ...The Wrangell-Petersburg Resource Advisory Committee will meet in Kake, Alaska. The committee is meeting as authorized under the Secure Rural Schools and Community Self-Determination Act (Pub. L. 110-343) and in compliance with the Federal Advisory Committee Act. The purpose of the meeting is to review project proposals and make project funding...

  2. 78 FR 38351 - Blood Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... will be closed to the public. Name of Committee: Blood Products Advisory Committee. General Function of..., Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA. FDA intends...

  3. 75 FR 72785 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... Committee) to discuss farm milk price volatility and dairy farmer profitability, and review various industry... milk price volatility and dairy farmer profitability. The Dairy Committee provides recommendations to...., Washington, DC 20250. The purpose of the meetings for the Dairy Committee is to: Discuss farm milk...

  4. 32 CFR 2700.51 - Information Security Oversight Committee.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Information Security Oversight Committee. 2700... MICRONESIAN STATUS NEGOTIATIONS SECURITY INFORMATION REGULATIONS Implementation and Review § 2700.51 Information Security Oversight Committee. The OMSN Information Security Oversight Committee shall be...

  5. 32 CFR 2700.51 - Information Security Oversight Committee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Information Security Oversight Committee. 2700... MICRONESIAN STATUS NEGOTIATIONS SECURITY INFORMATION REGULATIONS Implementation and Review § 2700.51 Information Security Oversight Committee. The OMSN Information Security Oversight Committee shall be...

  6. 75 FR 59680 - El Dorado County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ...The El Dorado County Resource Advisory Committee will meet in Placerville, California. The committee is meeting as authorized under the Secure Rural Schools and Community Self-Determination Act (Pub. L. 110-343) and in compliance with the Federal Advisory Committee Act. The Agenda for the meeting includes review of the October field trip, administrative costs update and a report out on......

  7. 75 FR 64736 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Vascular and...

  8. 75 FR 27794 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings... Development and Aging Integrated Review Group; International and Cooperative Projects--1 Study Section. Date...@csr.nih.gov . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group;...

  9. 78 FR 64968 - Advisory Committee on Commercial Operations of Customs and Border Protection (COAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... Supply Chain Subcommittee: Review and discuss recommendations regarding the Air Cargo Advance Screening... Distribution Chain Management in Intellectual Property Rights Compliance. 7. The Export Subcommittee: Review...). ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The...

  10. Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance.

    PubMed

    Balaskó, Márta; Soós, Szilvia; Székely, Miklós; Pétervári, Erika

    2014-11-01

    Leptin is produced mainly in the white adipose tissue and emerged as one of the key catabolic regulators of food intake and energy expenditure. During the course of aging characteristic alterations in body weight and body composition in humans and mammals, i.e. middle-aged obesity and aging anorexia and cachexia, suggest age-related regulatory changes in energy balance in the background. Aging has been associated with increased fat mass, central and peripheral leptin resistance as indicated by its failure to reduce food intake, to increase metabolic rate and thereby to induce weight loss. Leptin resistance is a common feature of aging and obesity (even in the young). The question arises whether aging or fat accumulation plays the primary role in the development of this resistance. The review focuses mainly on mechanisms and development of central leptin resistance. Age-related decline primarily affects the hypermetabolic component of central catabolic leptin actions, while the anorexigenic component is even growing stronger in the late phase of aging. Obesity enhances resistance to leptin at any age, particularly in old rats, calorie-restriction, on the other hand, increases responsiveness to leptin, especially in the oldest age-group. Thus, without obesity, leptin sensitivity appears not to decrease but to increase by old age. Interactions with other substances (e.g. insulin, cholecystokinin, endogenous cannabinoids) and life-style factors (e.g. exercise) in these age-related changes need to be investigated. PMID:25218974

  11. Cognitive Aging: What Every Geriatric Psychiatrist Should Know.

    PubMed

    Blazer, Dan G; Wallace, Robert B

    2016-09-01

    The authors of this review both served on the Institute of Medicine Committee, which produced the report "Cognitive Aging: Progress in Understanding and Opportunities for Action." In this review, the authors summarize portions of the report that are especially applicable to geriatric psychiatrists and other clinicians who work with the elderly. Cognitive aging is a universal phenomenon that must be better understood by clinicians, a trajectory across multiple cognitive functions upstream from mild neurocognitive and major neurocognitive disorders. The authors review the epidemiology, basic neurobiology, and evidence-based interventions for cognitive aging. PMID:27569270

  12. Committee Handbook for Common Learning.

    ERIC Educational Resources Information Center

    Burton, Sharon; And Others

    This manual on general education and common learning was prepared by and for the Dallas County Community College District's (DCCCD's) Committees for Common Learning (CCL's), which have been charged with reviewing the DCCCD's general education curriculum and degree requirements and making recommendations concerning common learning requirements and…

  13. Dental age estimation utilizing third molar development: A review of principles, methods, and population studies used in the United States.

    PubMed

    Lewis, James M; Senn, David R

    2010-09-10

    When an individual reaches the age of legal majority, their treatment within the criminal and civil legal systems is changed dramatically in the United States. Forensic odontologists are often asked to assist government agencies in estimating the ages of persons who may or may not have reached that legally important age. The third molars are the only teeth useful as forensic estimators of chronological age in the target age group. This study reviews the principles, methodology, and population data of the most commonly used technique in the United States, the analysis of the third molar development based on modified Demirjian staging. The method analyzes the developing third molar to estimate mean age, age intervals and the empirical probability that an individual has reached the anniversary of her or his eighteenth birthday.

  14. Electronic media use and sleep in school-aged children and adolescents: A review.

    PubMed

    Cain, Neralie; Gradisar, Michael

    2010-09-01

    Electronic media have often been considered to have a negative impact on the sleep of children and adolescents, but there are no comprehensive reviews of research in this area. The present study identified 36 papers that have investigated the relationship between sleep and electronic media in school-aged children and adolescents, including television viewing, use of computers, electronic gaming, and/or the internet, mobile telephones, and music. Many variables have been investigated across these studies, although delayed bedtime and shorter total sleep time have been found to be most consistently related to media use. A model of the mechanisms by which media use may affect sleep is presented and discussed as a vehicle for future research.

  15. The Investment Committee. AGB Effective Committee Series

    ERIC Educational Resources Information Center

    Yoder, Jay A.

    2011-01-01

    This publication is part of an AGB series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices included in this text support the objectives of board committees:…

  16. 76 FR 28443 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... receive briefings on the Federal Government's use of cloud computing; the Federal Emergency Management... cloud computing effort. The committee will meet in a closed session to review information...

  17. 77 FR 54554 - Notice of Public Meetings of Committees of the Administrative Conference of the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... Committee on Administration and Management, Committee on Collaborative Governance, Committee on Judicial... Collaborative Governance: Thursday, September 20, 2012 from 3 p.m. to 5 p.m. and Monday, October 15, 2012, from... Collaborative Governance), Stephanie Tatham (Committee on Judicial Review), or Reeve Bull (Committee...

  18. Hospital executives and ethics committees: an effective collaboration.

    PubMed

    Hilliard, B B; Coffey, B S; Johnson, R B

    1999-03-01

    Should hospital and healthcare executives participate on their organization's ethics committee? This question becomes more relevant in the current healthcare environment as nurses and physicians assume more managerial responsibilities. This article reviews functions of the ethics committee and discusses moral, conceptual, and practical issues surrounding managerial participation on these committees. The authors conclude that executive management's participation on ethics committees is both appropriate and necessary in the current healthcare environment.

  19. Screen Time and Sleep among School-Aged Children and Adolescents: A Systematic Literature Review

    PubMed Central

    Hale, Lauren; Guan, Stanford

    2015-01-01

    Summary We systematically examined and updated the scientific literature on the association between screen time (e.g., television, computers, video games, and mobile devices) and sleep outcomes among school-aged children and adolescents. We reviewed 67 studies published from 1999 to early 2014. We found that screen time is adversely associated with sleep outcomes (primarily shortened duration and delayed timing) in 90% of studies. Some of the results varied by type of screen exposure, age of participant, gender, and day of the week. While the evidence regarding the association between screen time and sleep is consistent, we discuss limitations of the current studies: 1.) causal association not confirmed; 2.) measurement error (of both screen time exposure and sleep measures); 3.) limited data on simultaneous use of multiple screens, characteristics and content of screens used. Youth should be advised to limit or reduce screen time exposure, especially before or during bedtime hours to minimize any harmful effects of screen time on sleep and well-being. Future research should better account for the methodological limitations of the extant studies, and seek to better understand the magnitude and mechanisms of the association. These steps will help the development and implementation of policies or interventions related to screen time among youth. PMID:25193149

  20. The influence of age and weight status on cardiac autonomic control in healthy children: a review.

    PubMed

    Eyre, E L J; Duncan, M J; Birch, S L; Fisher, J P

    2014-12-01

    Heart rate variability (HRV) analyses can provide a non-invasive evaluation of cardiac autonomic activity. How autonomic control normally develops in childhood and how this is affected by obesity remain incompletely understood. In this review we examine the evidence that childhood age and weight status influence autonomic control of the heart as assessed using HRV. Electronic databases (Pubmed, EMBASE and Cochrane Library) were searched for studies examining HRV in healthy children from birth to 18 years who adhered to the Task Force (1996) guidelines. Twenty-four studies met our inclusion criteria. Seven examined childhood age and HRV. A reduction in 24-hour LF:HF was reported from birth to infancy (1 year), while overall HRV (SDNN) showed a marked and progressive increase. From infancy to early-to-late childhood (from 12 months to 15 years) LF:HF ratio was reported to decline further albeit at a slower rate, while RMSSD and SDNN increased. Twenty studies examined the effects of weight status and body composition on HRV. In a majority of studies, obese children exhibited reductions in RMSSD (n = 8/13), pNN50% (n = 7/9) and HF power (n = 14/18), no difference was reported for LF (n = 10/18), while LF:HF ratio was elevated (n = 10/15). HRV changes during childhood are consistent with a marked and progressive increase in cardiac parasympathetic activity relative to sympathetic activity. Obesity disrupts the normal maturation of cardiac autonomic control.