Science.gov

Sample records for aging special emphasis

  1. 78 FR 63207 - Special Emphasis Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... HUMAN SERVICES Agency for Healthcare Research and Quality Special Emphasis Panel; Meeting AGENCY: Agency... Healthcare Research and Quality (AHRQ) Special Emphasis Panel (SEP) meeting on ``AHRQ RFA-HS-13-010, Closing... meeting are subject to change as priorities dictate. SUPPLEMENTARY INFORMATION: A Special Emphasis...

  2. 78 FR 5184 - Special Emphasis Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... HUMAN SERVICES Agency for Healthcare Research and Quality Special Emphasis Panel Meeting AGENCY: Agency... Healthcare Research and Quality (AHRQ) Special Emphasis Panel (SEP) meeting on ``Patient Centered Outcomes... INFORMATION: A Special Emphasis Panel is a group of experts in fields related to health care research who...

  3. 77 FR 55477 - Special Emphasis Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... HUMAN SERVICES Agency for Healthcare Research And Quality Special Emphasis Panel Meeting AGENCY: Agency... Agency for Healthcare Research and Quality (AHRQ) Special Emphasis Panel (SEP) meeting on ``Partnerships... subject to change as priorities dictate. SUPPLEMENTARY INFORMATION: A Special Emphasis Panel is a group...

  4. Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

    PubMed Central

    Kumar, Ashok

    2011-01-01

    Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults. PMID:21647396

  5. Pycnodysostosis with Special Emphasis on Dentofacial Characteristics

    PubMed Central

    Khoja, Aisha; Fida, Mubassar; Shaikh, Attiya

    2015-01-01

    Pycnodysostosis is an autosomal recessive disorder that manifests as osteosclerosis of the skeleton due to the defective osteoclasts mediated bone turnover. The diagnosis of this disorder is established on the basis of its characteristic features and must be differentially diagnosed with other bone disorders. Dental surgeons should be aware of the limitations and possible adverse oral complications such as osteomyelitis of bone in these patients. This will guide them in planning realistic treatment goals. This paper reports the clinical and radiographic features of pycnodysostosis with the great emphasis on its dentofacial characteristics. The aim of this case report is to give an insight into the etiology, pathogenesis, and differential diagnosis of this disorder and to prepare the dentists and maxillofacial surgeons to overcome the challenges in treating these patients. PMID:26649209

  6. Space Construction System Analysis. Special Emphasis Studies

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Generic concepts were analyzed to determine: (1) the maximum size of a deployable solar array which might be packaged into a single orbit payload bay; (2) the optimal overall shape of a large erectable structure for large satellite projects; (3) the optimization of electronic communication with emphasis on the number of antennas and their diameters; and (4) the number of beams, traffic growth, and projections and frequencies were found feasible to package a deployable solar array which could generate over 250 kilowatts of electrical power. Also, it was found that the linear-shaped erectable structure is better for ease of construction and installation of systems, and compares favorably on several other counts. The study of electronic communication technology indicated that proliferation of individual satellites will crowd the spectrum by the early 1990's, so that there will be a strong tendency toward a small number of communications platforms over the continental U.S.A. with many antennas and multiple spot beams.

  7. Pycnodysostosis with Special Emphasis on Dentofacial Characteristics.

    PubMed

    Khoja, Aisha; Fida, Mubassar; Shaikh, Attiya

    2015-01-01

    Pycnodysostosis is an autosomal recessive disorder that manifests as osteosclerosis of the skeleton due to the defective osteoclasts mediated bone turnover. The diagnosis of this disorder is established on the basis of its characteristic features and must be differentially diagnosed with other bone disorders. Dental surgeons should be aware of the limitations and possible adverse oral complications such as osteomyelitis of bone in these patients. This will guide them in planning realistic treatment goals. This paper reports the clinical and radiographic features of pycnodysostosis with the great emphasis on its dentofacial characteristics. The aim of this case report is to give an insight into the etiology, pathogenesis, and differential diagnosis of this disorder and to prepare the dentists and maxillofacial surgeons to overcome the challenges in treating these patients.

  8. Helminth parasites in ringed seals (Pusa hispida) from Svalbard, Norway with special emphasis on nematodes: variation with age, sex, diet, and location of host.

    PubMed

    Johansen, Carina E; Lydersen, Christian; Aspholm, Paul E; Haug, Tore; Kovacs, Kit M

    2010-10-01

    Complete gastrointestinal tracts from 257 ringed seals (Pusa hispida) from Svalbard, Norway, were examined for helminth parasites. Three different helminth groups were recorded (acanthocephalans 61.1%; nematodes 38%; cestodes 0.9%). Acanthocephalans (Polymorphidae) and cestodes (Anophryocephalus and Diphyllobothrium sp(p)., as well as unidentified species, were confined to the intestines. The anisakid nematodes Phocascaris phocae, Pseudoterranova sp(p)., Anisakis sp(p)., and Phocascaris/Contracaecum sp(p). were recorded in both stomachs and the anterior part of the small intestines. The abundance of nematodes and acanthocephalans varied significantly with sampling location of the seal hosts. This is likely due to the relative prevalence of Arctic versus Atlantic water in the different fjord systems, which strongly influences the age class and species of fish available as prey for the seals. Adult male ringed seals had significantly higher abundances of nematodes than did adult females or juveniles. Adult males also had significantly higher abundances of acanthocephalans than did adult females, but were not significantly different from juveniles in this regard. Nematode abundance increased significantly with age of male hosts, but this trend was lacking in female seals. Infection parameters appeared to be related to differences in the age of polar cod (Boreogadus saida) exploited by male, female, and juvenile seals.

  9. 76 FR 15984 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Combining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... Control Special Emphasis Panel (SEP): Combining Subjective and Objective Methods for Quantifying Contact... applications received in response to ``Combining Subjective and Objective Methods for Quantifying Contact Rates and Mixing Pattern in School-Aged Children, FOA CK11-006.'' Contact Person For More...

  10. 62 FR 2692 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-17

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent...

  11. 60 FR 14306 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-03-16

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting: Name: Special Emphasis Panel in Information, Robotics and Intelligent..., Acting Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation,...

  12. 61 FR 16126 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-04-11

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent..., Deputy Division Director, Robotics and Intelligent Systems, room 1115N, National Science Foundation,...

  13. 60 FR 57602 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-11-16

    ... Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent..., Acting Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation,...

  14. 61 FR 59247 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-11-21

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent...

  15. 61 FR 51726 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-10-03

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and...

  16. 61 FR 25920 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-05-23

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... NSF for financial support. Agenda: To review and evaluate Robotics and Machine Intelligence...

  17. 59 FR- Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-11-17

    ... FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In... Foundation announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and..., Acting Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation,...

  18. 59 FR- Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-11-25

    ... FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... Division Director, Robotics and Intelligence Room 1115, National Science Foundation, 4201 Wilson...

  19. 62 FR 2693 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-17

    ... From the Federal Register Online via the Government Publishing Office ] NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In... Foundation announces the following meeting. Name: Special Emphasis Panel in Information, Robotics...

  20. 60 FR 7798 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-02-09

    ... Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting: Name: Special Emphasis Panel in Information Robotics and Intelligent... Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201...

  1. 60 FR 20777 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-04-27

    ... Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201...

  2. 62 FR 115 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-02

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent...

  3. 60 FR 22413 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-05-05

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent..., Robotics and Intelligence, Room 1115, National Science Foundation, 4201 Wilson Blvd., Arlington, VA...

  4. 60 FR 17827 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-04-07

    ... Special Emphasis Panel in Information Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information Robotics and Intelligent... Moraff, Acting Deputy Division Director, Robotics and Intelligence, Room 1115, National...

  5. 60 FR 9055 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-02-16

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. ] Name: Special Emphasis Panel in Information, Robotics and Intelligent... Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201...

  6. 60 FR 3276 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-01-13

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting In accordance with the... the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent Systems... Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201 Wilson Blvd.,...

  7. 60 FR 57877 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-11-22

    ... Special Emphasis Panel in Information Robotics and Intelligent Systems; Meeting In accordance with the... the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent Systems... Deputy Division Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201...

  8. 62 FR 115 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-02

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and...

  9. 62 FR 2692 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-17

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent...

  10. 59 FR- Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-09-01

    ... FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... Director, Robotics and Intelligence Systems, Rm. 1115, National Science Foundation, 4201 Wilson...

  11. 59 FR- Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-11-25

    ... FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Meeting In accordance... announces the following meeting. Name: Special Emphasis in Information, Robotics and Intelligent Systems... Director, Robotics and Intelligence, Room 1115, National Science Foundation, 4201 Wilson Blvd.,...

  12. 63 FR 20434 - Special Emphasis Panel in Information, Robotics, and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1998-04-24

    ... From the Federal Register Online via the Government Publishing Office ] NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics, and Intelligent Systems; Notice of Meeting In... Foundation announces the following meeting. Name: Special Emphasis Panel in Information, Robotics...

  13. 61 FR 57480 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-11-06

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice Of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information Robotics & Intelligent...

  14. 62 FR 999 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-07

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting: Name: Special Emphasis Panel in Information, Robotics and Intelligent...

  15. 61 FR 6866 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-02-22

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... Division Director, Robotics and Intelligent Systems, room 1115N, National Science Foundation, 4201...

  16. 60 FR 27797 - Special Emphasis Panel in Information Robotics and Intelligent Systems; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-05-25

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information Robotics and Intelligent Systems; Meeting In accordance with the... the following meeting. Name: Special Emphasis Panel in Information Robotics and Intelligent...

  17. 61 FR 15149 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-04-04

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligence... Division Director, Robotics and Intelligent Systems, room 1115N, National Science Foundation, 4201...

  18. Determination of triglycerides with special emphasis on biosensors: a review.

    PubMed

    Pundir, C S; Narang, Jagriti

    2013-10-01

    Triglycerides (TG) are transesterification product of fatty acids and glycerol and engaged in the transportation of fats. Elevated triglyceride level is associated with coronary heart disease (CAD), atherosclerosis and hypolipoprotenemia. Convenient and reproducible assay systems based on enzymes are an attractive alternative to conventional analytical methods. Triglyceride biosensors (TGBs) are based on either measurement of oxygen consumed or electron generated from splitting of H2O2, an ultimate product, of immobilized enzymes. TGBs work optimally within 2-900 s, between pH 6.4-8.5 and the potential 0.5-4V. TGBs measure TG level in serum directly and can be used over a period of 14 to 168 days. This review describes the analytic characteristics of various methods available for determination of TGs with special emphasis on TGBs.

  19. 76 FR 27327 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Combining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Control Special Emphasis Panel (SEP): Combining Subjective and Objective Methods for Quantifying Contact... 3, 2011 (Closed). Place: Teleconference. Contact Person For More Information: Gregory Anderson,...

  20. 75 FR 78999 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Centers for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Control Special Emphasis Panel (SEP): Centers for Autism and Developmental Disabilities Research and... Discussed: The meeting will include the initial review, discussion, and evaluation of ``Centers for...

  1. 76 FR 13414 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel: Continuation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... Control Special Emphasis Panel: Continuation of the National Mesothelioma Virtual Bank for Translational... initial review, discussion, and evaluation of ``Continuation of the National Mesothelioma Virtual Bank...

  2. 59 FR- Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-09-29

    ... FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In... Moraff, Acting Deputy Division Director, Robotics and Intelligence Systems, Rm. 1115, National...

  3. 78 FR 43003 - Biomedical Laboratory Research and Development Service, Special Emphasis Panel-Amyotrophic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... Lateral Sclerosis (ALS) Brain Bank, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the Federal Advisory Committee Act, 5 U.S.C. App., that the Special Emphasis Panel--ALS Brain Bank...) (6) and (9)(B). The purpose of this Special Emphasis Panel is to review the VA ALS Brain Bank for...

  4. 62 FR 2693 - Special Emphasis Panel in Information, Robotics and Intelligent System; Notice Of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-17

    ... Special Emphasis Panel in Information, Robotics and Intelligent System; Notice Of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent (1200... submitted to NSF for financial support. Agenda: To review and evaluate Robotics and Machine and...

  5. 62 FR 116 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-02

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent... concerning proposals submitted to NSF for financial support. Agenda: To review and evaluate Robotics...

  6. 62 FR 27074 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-05-16

    ... Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meetings This notice is...: Special Emphasis Panel in Information, Robotics and Intelligent Systems (1200). 1. Date: June 2-3, 1997...: Robotics and Machine Intelligence Program Computer Vision. 2. Date: June 9-10, 1997. Contact: Dr....

  7. Sinusitis: Special Considerations for Aging Patients

    MedlinePlus

    ... ENT Doctor Near You Sinusitis: Special Considerations for Aging Patients Sinusitis: Special Considerations for Aging Patients Patient ... for evaluation and possible surgical management. Sources For Aging Patients: Administration on Aging (AoA), U.S. Department of ...

  8. 75 FR 10490 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Member...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... Control Special Emphasis Panel (SEP): Member Conflict Review, Program Announcement (PA) 07-318, Initial... review, discussion, and evaluation of ``Member Conflict Review, PA 07- 318.'' Contact Person for...

  9. 75 FR 9606 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... Control Special Emphasis Panel (SEP): Public Health Research on Craniofacial Malformation, Funding... review, discussion, and evaluation of applications received in response to ``Public Health Research on... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  10. 77 FR 3269 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... Prevention (CDC) Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data... Review Officer, CDC, 4770 Buford Highway NE., Mailstop F-46, Atlanta, Georgia 30341, Telephone: (770)...

  11. 75 FR 77645 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pregnancy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... Control Special Emphasis Panel (SEP): Pregnancy Risk Assessment Monitoring System (PRAMS), DP11-001 Panel..., discussion, and evaluation of ``Pregnancy Risk Assessment Monitoring System (PRAMS), DP11-001 Panel...

  12. 76 FR 5379 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pregnancy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... Control Special Emphasis Panel (SEP): Pregnancy Risk Assessment Monitoring System (PRAMS), DP11-001 Panels... Be Discussed: The meeting will include the initial review, discussion, and evaluation of...

  13. 76 FR 3909 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Family...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Control Special Emphasis Panel (SEP): Family History and Diamond Blackfan Anemia, DD11- 010, Initial... ``Family History and Diamond Blackfan Anemia, DD11-010, initial review.'' Contact Person for...

  14. 75 FR 12243 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Translating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... Control Special Emphasis Panel (SEP): Translating Research Into Healthy Eye and Vision Loss Prevention... Research into Healthy Eye and Vision Loss Prevention, RFA DP 10- 004.'' Contact Person for More...

  15. 75 FR 46952 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): National Human Immunodeficiency Virus (HIV) Behavioral...

  16. 75 FR 6675 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human Immunodeficiency Virus (HIV) Prevention Projects for...

  17. 75 FR 9423 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Impact of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Control Special Emphasis Panel (SEP): Impact of Japanese Encephalitis Vaccination in Cambodia, Funding... Vaccination in Cambodia, FOA CK10-003.'' Contact Person for More Information: Gregory Anderson, M.S.,...

  18. 75 FR 78999 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Maternal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Control Special Emphasis Panel (SEP): Maternal Vitamin D Status and Preterm Birth, DP11-002, Initial... ``Maternal Vitamin D Status and Preterm Birth, DP11-002, initial review.'' Contact Person for...

  19. Special Operations Forces Language and Culture Needs Assessment Project: Training Emphasis: Language and Culture

    DTIC Science & Technology

    2010-02-25

    DATES COVERED (From - To) February 2010 4. TITLE AND SUBTITLE Special Operations Forces Language and Culture Needs Assessment: Training Emphasis...Language and Culture 5a. CONTRACT NUMBER N65236-08-D-6805 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) Special Operations Forces Culture and Language Office HQ USSOCOM Attn: SOKL-J7—SOFLO 7701 Tampa Point

  20. 76 FR 4702 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... Control Special Emphasis Panel (SEP): Cooperative Agreement Program for the National Academic Centers of... meeting: Times and Dates: 8 a.m.-5 p.m., February 17, 2011 (Closed). 8 a.m.-5 p.m., February 18, 2011..., Management Analysis and Services Office, CDC, pursuant to Section 10(d) of Public Law 92-463. Matters To...

  1. 78 FR 66938 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review Notice of Cancellation: This notice concerns.... Department of Health and Human Services, Centers for Disease Control and Prevention, from October 1-16,...

  2. 78 FR 66937 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review The meeting announced below concerns Capacity...), the Centers for Disease Control and Prevention (CDC) announces the aforementioned SEP: Times and...

  3. 78 FR 66937 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review The meeting announced below concerns Occupational... 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control...

  4. 78 FR 66937 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review Notice of Cancellation: This notice concerns.... Department of Health and Human Services, Centers for Disease Control and Prevention, from October 1-16,...

  5. 76 FR 7217 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Enhanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Enhanced Surveillance for New Vaccine Preventable Disease, Funding... for New Vaccine Preventable Disease, FOA IP11-010, initial review.'' CONTACT PERSON FOR...

  6. 78 FR 62636 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Control Special Emphasis Panel (SEP): Initial Review The meeting announced below concerns Cooperative... the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92-463. Matters To... received in response to Cooperative Agreement on Occupational Health with the World Health...

  7. 75 FR 30844 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Conducting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... Control Special Emphasis Panel (SEP): Conducting Public Health Research in Kenya (Panel B), Funding..., discussion, and evaluation of applications received in response to ``Conducting Public Health Research in... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  8. 75 FR 28810 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Conducting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... Control Special Emphasis Panel (SEP): Conducting Public Health Research in Kenya (Panel C), Funding..., discussion, and evaluation of applications received in response to ``Conducting Public Health Research in... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  9. 76 FR 13413 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP); Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... Control Special Emphasis Panel (SEP); Meeting Studies at the Animal-Human Interface of Influenza and Other... of Influenza-Associated Community- Acquired Pneumonia in Hospitalized Persons Study, FOA IP11-011..., FOA IP11-012; Influenza Vaccine Efficacy in Tropical and Developing Countries, FOA IP11-013;...

  10. 64 FR 39144 - Disease, Disability and Injury Prevention and Control Special Emphasis Panel: Implementation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1999-07-21

    ... Control Special Emphasis Panel: Implementation of the National Occupational Research Agenda (NORA), RFA OH-99-002, Program Area #5, Surveillance Research Methodology In accordance with section 10(a)(2) of the... Area #5, Surveillance Research Methodology, meeting. Times and Dates: 10 a.m.-10:30 a.m., August...

  11. 76 FR 82299 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... to ``Data Coordinating Center for Autism and Other Developmental Disabilities Research and... Control Special Emphasis Panel (SEP): Data Coordinating Center for Autism and Other Developmental Disabilities Research and Epidemiologic Studies, RFA DD12-001, Initial Review In accordance with Section...

  12. 76 FR 13621 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Family...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Family History and Diamond Blackfan Anemia, DD11- 010,...

  13. 75 FR 28261 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Improved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Improved Diagnostics for Lyme Borreliosis, Funding Opportunity... Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces...

  14. 75 FR 28625 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Assessment of Post-Treatment Lyme Disease Syndrome, Funding...-Treatment Lyme Disease Syndrome,'' FOA CK10-004. Contact Person for More Information: Maurine Goodman,...

  15. 76 FR 9785 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human Immunodeficiency Virus (HIV) Prevention Projects for Young...

  16. 76 FR 27327 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Virologic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Virologic Evaluation of the Modes of Influenza Virus...

  17. 78 FR 78966 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review The meeting announced below concerns Capacity Building Assistance for High Impact...

  18. 75 FR 29561 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Surveillance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... No: 2010-12627] DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Surveillance, Natural... Officer, National Center for Chronic Disease Prevention and Health Promotion, Office of the...

  19. 61 FR 58597 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-11-15

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... submitted to NSF for financial support. Agenda: To review and evaluate Robotics and Machine...

  20. 61 FR 58597 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-11-15

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as amended), the National Science...

  1. 62 FR 19623 - Special Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-04-22

    ... [Federal Register Volume 62, Number 77 (Tuesday, April 22, 1997)] [Notices] [Page 19623] [FR Doc No: 97-10374] NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics and... Panel in Information, Robotics and Intelligent Systems (1200). Date and Time: May 5-6, 1997, 8:30...

  2. 64 FR 54368 - Special Emphasis Panel in Information, Robotics, and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1999-10-06

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Special Emphasis Panel in Information, Robotics, and Intelligent Systems; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as amended), the National Science...

  3. 76 FR 10908 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Maternal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Maternal Vitamin D Status and Preterm Birth, DP11-002,...

  4. 76 FR 13621 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel; Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel; Teleconference Disease, Disability, and Injury Prevention and Control... Centers for Disease Control and Prevention (CDC) announces the aforementioned meeting: Time and Date: 11...

  5. 75 FR 78998 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Addressing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Addressing Global TB Prevention and Control in all Populations and Strengthening Health...

  6. 75 FR 28622 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Conducting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... Control Special Emphasis Panel (SEP): Conducting Public Health Research in Kenya (U01)(Panel A), Funding..., discussion, and evaluation of applications received in response to ``Conducting Public Health Research in... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  7. 76 FR 4911 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel: Occupational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Control Special Emphasis Panel: Occupational Safety and Health Educational Research Centers, Program... Educational Research Centers, PAR 10-217.'' There were site visits conducted at the University of Cincinnati... Educational Research Centers, PAR 10-217. Contact Person for More Information: M. Chris Langub,...

  8. 75 FR 13769 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Natural...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Natural Experiments and Effectiveness Studies To Identify the Best..., discussion, and evaluation of ``Natural Experiments and Effectiveness Studies to Identify the Best Policy...

  9. 76 FR 367 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Minority HIV...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... Control Special Emphasis Panel (SEP): Minority HIV/AIDS Research Initiative (MARI) To Build Capacity in Black and Hispanic Communities and Among Black and Hispanic Researchers To Conduct HIV/AIDS... evaluation of applications received in response to ``Minority HIV/AIDS Research Initiative (MARI) to...

  10. Exercise and sleep in aging: emphasis on serotonin.

    PubMed

    Melancon, M O; Lorrain, D; Dionne, I J

    2014-10-01

    Reductions in central serotonin activity with aging might be involved in sleep-related disorders in later life. Although the beneficial effects of aerobic exercise on sleep are not new, sleep represents a complex recurring state of unconsciousness involving many lines of transmitters which remains only partly clear despite intense ongoing research. It is known that serotonin released into diencephalon and cerebrum might play a key inhibitory role to help promote sleep, likely through an active inhibition of supraspinal neural networks. Several lines of evidence support the stimulatory effects of exercise on higher serotonergic pathways. Hence, exercise has proved to elicit acute elevations in forebrain serotonin concentrations, an effect that waned upon cessation of exercise. While adequate exercise training might lead to adaptations in higher serotonergic networks (desensitization of forebrain receptors), excessive training has been linked to serious brain serotonergic maladaptations accompanied by insomnia. Dietary supplementation of tryptophan (the only serotonin precursor) is known to stimulate serotonergic activity and promote sleep, whereas acute tryptophan depletion causes deleterious effects on sleep. Regarding sleep-wake regulation, exercise has proved to accelerate resynchronization of the biological clock to new light-dark cycles following imposition of phase shifts in laboratory animals. Noteworthy, the effect of increased serotonergic transmission on wake state appears to be biphasic, i.e. promote wake and thereafter drowsiness. Therefore, it might be possible that acute aerobic exercise would act on sleep by increasing activity of ascending brain serotonergic projections, though additional work is warranted to better understand the implication of serotonin in the exercise-sleep axis.

  11. Geostationary platform systems concepts definition follow-on study. Volume 2A: Technical Task 2 LSST special emphasis

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The results of the Large Space Systems Technology special emphasis task are presented. The task was an analysis of structural requirements deriving from the initial Phase A Operational Geostationary Platform study.

  12. Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals.

    PubMed

    Healy, Anne Marie; Worku, Zelalem Ayenew; Kumar, Dinesh; Madi, Atif M

    2017-03-22

    Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, affecting the internal energy and enthalpy, and the degree of disorder, affecting the entropy. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. Hence, solid forms of APIs play a vital role in drug discovery and development in the context of optimization of bioavailability, filing intellectual property rights and developing suitable manufacturing methods. In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules.

  13. Numerical investigation of three-dimensional cloud cavitation with special emphasis on collapse induced shock dynamics

    NASA Astrophysics Data System (ADS)

    Schnerr, Günter H.; Sezal, Ismail H.; Schmidt, Steffen J.

    2008-04-01

    The aim of the present investigation is to model and analyze compressible three-dimensional (3D) cavitating liquid flows with special emphasis on the detection of shock formation and propagation. We recently developed the conservative finite volume method CATUM (Cavitation Technische Universität München), which enables us to simulate unsteady 3D liquid flows with phase transition at all Mach numbers. The compressible formulation of the governing equations together with the thermodynamic closure relations are solved by a modified Riemann approach by using time steps down to nanoseconds. This high temporal resolution is necessary to resolve the wave dynamics that leads to acoustic cavitation as well as to detect regions of instantaneous high pressure loads. The proposed two-phase model based on the integral average properties of thermodynamic quantities is first validated against the solution of the Rayleigh-Plesset equation for the collapse of a single bubble. The computational fluid dynamics tool CATUM is then applied to the numerical simulation of the highly unsteady two-phase flow around a 3D twisted hydrofoil. This specific hydrofoil allows a detailed study of sheet and cloud cavitation structures related to 3D shock dynamics emerging from collapsing vapor regions. The time dependent development of vapor clouds, their shedding mechanism, and the resulting unsteady variation of lift and drag are discussed in detail. We identify instantaneous local pressure peaks of the order of 100bar, which are thought to be responsible for the erosive damage of the surface of the hydrofoil.

  14. Comparative assessment of metallurgical recovery of metals from electronic waste with special emphasis on bioleaching.

    PubMed

    Priya, Anshu; Hait, Subrata

    2017-01-14

    Waste electrical and electronic equipment (WEEE) or electronic waste (e-waste) is one of the fastest growing waste streams in the urban environment worldwide. The core component of printed circuit board (PCB) in e-waste contains a complex array of metals in rich quantity, some of which are toxic to the environment and all of which are valuable resources. Therefore, the recycling of e-waste is an important aspect not only from the point of waste treatment but also from the recovery of metals for economic growth. Conventional approaches for recovery of metals from e-waste, viz. pyrometallurgical and hydrometallurgical techniques, are rapid and efficient, but cause secondary pollution and economically unviable. Limitations of the conventional techniques have led to a shift towards biometallurgical technique involving microbiological leaching of metals from e-waste in eco-friendly manner. However, optimization of certain biotic and abiotic factors such as microbial species, pH, temperature, nutrients, and aeration rate affect the bioleaching process and can lead to profitable recovery of metals from e-waste. The present review provides a comprehensive assessment on the metallurgical techniques for recovery of metals from e-waste with special emphasis on bioleaching process and the associated factors.

  15. Molecular phylogeny of rodents, with special emphasis on murids: evidence from nuclear gene LCAT.

    PubMed

    Robinson, M; Catzeflis, F; Briolay, J; Mouchiroud, D

    1997-12-01

    Phylogenetic relationships among 19 extant species of rodents, with special emphasis on rats, mice, and allied Muroidea, were studied using sequences of the nuclear protein-coding gene LCAT (lecithin:cholesterol acyltransferase), an enzyme of cholesterol metabolism. Analysis of 705 base pairs from the exonic regions of LCAT confirmed known groupings in and around Muroidea. Strong support was found for the families Sciuridae (squirrel and marmot) and Gliridae (dormice) and for suprafamilial taxa Muroidea and Caviomorpha (guinea pig and allies). Within Muroidea, the first branching leads to the fossorial mole rats Spalacinae and bamboo rats Rhizomyinae. The other Muroidea appear as a polytomy from which are issued Gerbillinae (gerbils), Murinae (rats and mice), Sigmodontinae (New World cricetids), Cricetinae (hamsters), and Arvicolinae (voles). Evidence from LCAT sequences agrees with that from a number of previous molecular and morphological studies, both concerning branching orders inside Muroidea and the bush-like radiation of rodent suprafamilial taxa (caviomorphs, sciurids, glirids, muroids), thus suggesting that this nuclear gene is an appropriate candidate for addressing questions of rodents relationships.

  16. 75 FR 13560 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): RFA DD 10...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... Control Special Emphasis Panel (SEP): RFA DD 10-002 Public Health Research on Spina Bifida, RFA DD 10-003 Public Health Research on Children and Adults Living With Spina Bifida, RFA DD 10-004 Developing a... Health Research on Spina Bifida, RFA DD 10-003 Public Health Research on Children and Adults Living...

  17. Determination of lactic acid with special emphasis on biosensing methods: A review.

    PubMed

    Pundir, Chandra S; Narwal, Vinay; Batra, Bhawna

    2016-12-15

    Lactic acid (2-Hydroxypropanoic acid) is generated from pyruvic acid under anaerobic condition in skeletal muscles, brain, red blood cells, and kidney. Lactate in normal human subjects get cleared very quickly at a rate of 320mmol/L/hr, mostly by liver metabolism and re-conversion of lactate back to pyruvate. Measurement of lactate level in serum is required for the differential diagnosis and medical management of hyperlactatemia, cardiac arrest and resuscitation, sepsis, reduced renal excretion, hypoxia induced cancer, decreased extra hepatic metabolism, intestinal infarction and lactic acidosis. Determination of lactate is also important in dairy products and beverages to access their quality. Among the various methods available for detection of lactate, most are complicated, nonspecific, less sensitive and require time-consuming sample pretreatment, expensive instrumental set-up and trained persons to operate, specifically for chromatographic methods. Biosensing methods overcome these drawbacks, as these are simple, fast, specific and highly sensitive. Lactate biosensors reported so far, work optimally within 3-180s, between pH, 5.5-8.5 and temperature 22°C to 37°C and lactate concentration ranging from 10 to 2000µM. These biosensors have been employed to measure lactate level in embryonic cell culture, beverages, urine, and serum samples and reused upto 200-times within a period of 7-216 days. This review presents the principles, merits and demerits of various analytical methods for lactate determination with special emphasis on lactate biosensors. The future perspective for improvement of analytic performance of lactate biosensors are discussed.

  18. 78 FR 57167 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... . Name of Committee: National Institute on Aging Special Emphasis Panel; Genetic Regulators. Date...@nia.nih.gov . Name of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer...

  19. Applying Continuous Quality Improvement Principles in Secondary School Vocational Education, with Emphasis on Special Populations.

    ERIC Educational Resources Information Center

    McLean, Gary N.

    1993-01-01

    Principles of quality management applicable to education for secondary special populations include process orientation, cascading, top commitment, vertical/horizontal communication, continuous improvement, shared vision, primacy of customers, investment in people, constancy of purpose, and shared goal setting. (JOW)

  20. Planning and Implementing Career Education for the Special Student, with Emphasis on the Leisure Occupations.

    ERIC Educational Resources Information Center

    Vinton, Dennis A.; And Others

    A program of career education for exceptional students in the leisure occupations is described. It is explained that the book is designed for regular and special class teachers. Chapters one and two present information on career education principles and implementation. Chapters three through five deal with practical teaching concerns. Behavioral…

  1. Radiation risk modeling of thyroid cancer with special emphasis on the Chernobyl epidemiological data.

    PubMed

    Walsh, L; Jacob, P; Kaiser, J C

    2009-10-01

    Two recent studies analyzed thyroid cancer incidence in Belarus and Ukraine during the period from 1990 to 2001, for the birth cohort 1968 to 1985, and the related (131)I exposure associated with the Chernobyl accident in 1986. Contradictory age-at-exposure and time-since-exposure effect modifications of the excess relative risk (ERR) were reported. The present study identifies the choice of baseline modeling method as the reason for the conflicting results. Various quality-of-fit criteria favor a parametric baseline model to various categorical baseline models. The model with a parametric baseline results in a decrease of the ERR by a factor of about 0.2 from an age at exposure of 5 years to an age at exposure of 15 years (for a time since exposure of 12 years) and a decrease of the ERR from a time since exposure of 4 years to a time since exposure of 14 years of about 0.25 (for an age at exposure of 10 years). Central ERR estimates (of about 20 at 1 Gy for an age at exposure of 10 years and an attained age of 20 years) and their ratios for females compared to males (about 0.3) turn out to be relatively independent of the modeling. Excess absolute risk estimates are also predicted to be very similar from the different models. Risk models with parametric and categorical baselines were also applied to thyroid cancer incidence among the atomic bomb survivors. For young ages at exposure, the ERR values in the model with a parametric baseline are larger. Both data sets cover the period of 12 to 15 years since exposure. For this period, higher ERR values and a stronger age-at-exposure modification are found for the Chernobyl data set. Based on the results of the study, it is recommended to test parametric and categorical baseline models in risk analyses.

  2. Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

    PubMed Central

    Kinoshita, Taroh; Fujita, Morihisa

    2016-01-01

    Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6Manα-4GlNα-6myoinositol-P-lipid. The lipid part is either phosphatidylinositol of diacyl or 1-alkyl-2-acyl form, or inositol phosphoceramide. GPIs are attached to proteins via an amide bond between the C-terminal carboxyl group and an amino group of EtNP. Fatty chains of inositol phospholipids are inserted into the outer leaflet of the plasma membrane. More than 150 different human proteins are GPI anchored, whose functions include enzymes, adhesion molecules, receptors, protease inhibitors, transcytotic transporters, and complement regulators. GPI modification imparts proteins with unique characteristics, such as association with membrane microdomains or rafts, transient homodimerization, release from the membrane by cleavage in the GPI moiety, and apical sorting in polarized cells. GPI anchoring is essential for mammalian embryogenesis, development, neurogenesis, fertilization, and immune system. Mutations in genes involved in remodeling of the GPI lipid moiety cause human diseases characterized by neurological abnormalities. Yeast Saccharomyces cerevisiae has >60 GPI-anchored proteins (GPI-APs). GPI is essential for growth of yeast. In this review, we discuss biosynthesis of GPI-APs in mammalian cells and yeast with emphasis on the lipid moiety. PMID:26563290

  3. The Age and Qualifications of Special Education Staff in Australia

    ERIC Educational Resources Information Center

    Thomas, Tony

    2009-01-01

    This article reports on the results of a survey distributed in April 2007 to government special education schools and settings throughout Australia. The survey collected information about the age and special education qualifications of teaching staff. It followed a similar survey that was distributed in May 2006 to Victorian special schools that…

  4. Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin

    PubMed Central

    Angoa-Pérez, Mariana; Kuhn, Donald M.

    2016-01-01

    sexual behavior and the participation of the serotonin system in the modulation of these behaviors with emphasis on rodents. PMID:26110223

  5. The brain-pituitary-gonad axis in male teleosts, with special emphasis on flatfish (Pleuronectiformes).

    PubMed

    Weltzien, Finn-Arne; Andersson, Eva; Andersen, Øivind; Shalchian-Tabrizi, Kamran; Norberg, Birgitta

    2004-03-01

    The key component regulating vertebrate puberty and sexual maturation is the endocrine system primarily effectuated along the brain-pituitary-gonad (BPG) axis. By far most investigations on the teleost BPG axis have been performed on salmonids, carps, catfish and eels. Accordingly, earlier reviews on the BPG axis in teleosts have focused on these species, and mainly on females (e.g. 'Fish Physiology, vol. IXA. Reproduction (1983) pp. 97'; 'Proceedings of the Fourth International Symposium on the Reproductive Physiology of Fish. FishSymp91, Sheffield, UK, 1991, pp. 2'; 'Curr. Top. Dev. Biol. 30 (1995) pp. 103'; 'Rev. Fish Biol. Fish. 7 (1997) pp. 173'; 'Proceedings of the Sixth International Symposium on the Reproductive Physiology of Fish. John Grieg A/S, Bergen, Norway, 2000, pp. 211'). However, in recent years new data have emerged on the BPG axis in flatfish, especially at the level of the brain and pituitary. The evolutionarily advanced flatfishes are important model species both from an evolutionary point of view and also because many are candidates for aquaculture. The scope of this paper is to review the present status on the male teleost BPG axis, with an emphasis on flatfish. In doing so, we will first discuss the present understanding of the individual constituents of the axis in the best studied teleost models, and thereafter discuss available data on flatfish. Of the three constituents of the BPG axis, we will focus especially on the pituitary and gonadotropins. In addition to reviewing recent information on flatfish, we present some entirely new information on the phylogeny and molecular structure of teleost gonadotropins.

  6. Satellite Power Systems (SPS) concept definition study, exhibit C. Volume 5: Special emphasis studies

    NASA Technical Reports Server (NTRS)

    Hanley, G.

    1979-01-01

    Specific areas were analyzed and identified as high priority for more in-depth analysis. These areas were: (1) rectenna constructability; (2) satellite constructability; (3) support systems constructability; (4) space environmental analysis, and (5) special end-to-end analyses. Baseline requirements specified coplanar solar blankets and an end mounted antenna, utilizing either GaAlAs solar cells and employing a CR of 2, or Si cells. Several configurations were analyzed. Utilizing the preferred configuration as a baseline, a satellite construction base was defined, precursor operations incident to establishment of orbital support facilities identified, and the satellite construction sequence and procedures developed. Since the baseline specifies sixty instead of one hundred and twenty satellites to be constructed in a thirty year period, mass flow to orbit requirements were revised and new traffic models established. Launch site requirements (exclusive of actual launch operations) in terms of manpower and building space were defined.

  7. The complexities of defining optimal sleep: empirical and theoretical considerations with a special emphasis on children.

    PubMed

    Blunden, Sarah; Galland, Barbara

    2014-10-01

    The main aim of this paper is to consider relevant theoretical and empirical factors defining optimal sleep, and assess the relative importance of each in developing a working definition for, or guidelines about, optimal sleep, particularly in children. We consider whether optimal sleep is an issue of sleep quantity or of sleep quality. Sleep quantity is discussed in terms of duration, timing, variability and dose-response relationships. Sleep quality is explored in relation to continuity, sleepiness, sleep architecture and daytime behaviour. Potential limitations of sleep research in children are discussed, specifically the loss of research precision inherent in sleep deprivation protocols involving children. We discuss which outcomes are the most important to measure. We consider the notion that insufficient sleep may be a totally subjective finding, is impacted by the age of the reporter, driven by socio-cultural patterns and sleep-wake habits, and that, in some individuals, the driver for insufficient sleep can be viewed in terms of a cost-benefit relationship, curtailing sleep in order to perform better while awake. We conclude that defining optimal sleep is complex. The only method of capturing this elusive concept may be by somnotypology, taking into account duration, quality, age, gender, race, culture, the task at hand, and an individual's position in both sleep-alert and morningness-eveningness continuums. At the experimental level, a unified approach by researchers to establish standardized protocols to evaluate optimal sleep across paediatric age groups is required.

  8. Advanced system identification techniques for wind turbine structures with special emphasis on modal parameters

    NASA Astrophysics Data System (ADS)

    Bialasiewicz, J. T.

    1995-06-01

    The goal is to develop advanced system identification techniques that can be used to accurately measure the frequency response functions of a wind-turbine structure immersed in wind noise. To allow for accurate identification, the authors have developed a special test signal called the pseudo-random binary sequence (PRBS). The Matlab program that generates this signal allows the user to interactively tailor its parameters for the frequency range of interest based on the response of the wind turbine under test. By controlling NREL's Mobile Hydraulic Shaker System, which is attached to the wind turbine structure, the PRBS signal produces the wide-band excitation necessary to perform system identification in the presence of wind noise. The techniques presented here will enable researchers to obtain modal parameters from an operating wind turbine, including frequencies, damping coefficients, and mode shapes. More importantly, the algorithms they have developed and tested (so far using input-output data from a simulated structure) permit state-space representation of the system under test, particularly the modal state space representation. This is the only system description that reveals the internal behavior of the system, such as the interaction between the physical parameters, and which, in contrast to transfer functions, is valid for non-zero initial conditions.

  9. The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing.

    PubMed

    Moura, João; Børsheim, Elisabet; Carvalho, Eugenia

    2014-09-29

    Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing.

  10. Modelling of ICRF heating in DEMO with special emphasis on bulk ion heating

    SciTech Connect

    Gallart, Dani; Mantsinen, Mervi; Kazakov, Yevgen

    2015-12-10

    Ion cyclotron resonance frequency (ICRF) heating is one of the auxiliary heating schemes presently envisaged for ITER and DEMO. In this paper we analyse the potential of ICRF waves to heat the fuel ions in DEMO. Our analysis is carried out for the DEMO1 Reference Scenario from October 2013 (B = 6.8 T, I = 18.6 MA, R = 9.25 m, a = 2.64 m) optimized for a maximum pulse length of 2.3 hrs using the ICRF modelling codes PION and TORIC. We focus on second harmonic heating of tritium and fundamental minority heating of {sup 3}He ions (with a few percent of {sup 3}He) in a 50%:50% D-T plasma. The dependence of the ICRF characteristics and the ICRF-accelerated ions on the ICRF and plasma parameters is investigated, giving special attention to the DEMO design point at a core plasma temperature of 30 keV and an electron density of 1.2·10{sup 20} m{sup −3}.

  11. The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing

    PubMed Central

    Moura, João; Børsheim, Elisabet; Carvalho, Eugenia

    2014-01-01

    Overweight and obesity are major problems in today’s society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing. PMID:25268390

  12. Sports-related acute and chronic avulsion injuries in children and adolescents with special emphasis on tennis.

    PubMed

    Vandervliet, Everhard J M; Vanhoenacker, Filip M; Snoeckx, Annemie; Gielen, Jan L; Van Dyck, Pieter; Parizel, Paul M

    2007-11-01

    Acute and chronic sports-related muscle and tendon injuries are not infrequent in youngsters. In particular, the physis is prone to trauma as it constitutes the weakest part of the immature skeleton. The type of sports activity determines the location of the lesion. Most commonly, apophyses of the hip and pelvis are subject to avulsion. The purpose of this paper is to give a short overview of the pathogenesis, location, prevalence and imaging characteristics of acute and chronic avulsion injuries in the immature skeleton, with special emphasis on tennis-related injuries. Tennis-related injuries particularly involve apophyses of the ischial tuberosity, the anterior inferior or superior iliac spine and the iliac crest.

  13. Isolation of compound and CNS depressant activities of Mikania scandens Willd with special emphasis to brain biogenic amines in mice.

    PubMed

    Pal, Dilipkumar; Mazumder, Upal Kanti

    2014-12-01

    Mikania scandens, a twining herb that grows as a weed in India and Bangladesh is used as vegetables and is a good source of vitamin A, C, B complex, mikanin, sesquiterpenes, betasitosterin, stigmasterol and friedelin. The present communication reports CNS depressant activities with special emphasis to brain biogenic amines in mice. Ethanol extract of leaves of M. scandens (EEMS) was prepared by Soxhalation and analyzed chemically. EEMS potentiated sleeping time induced by pentobarbitone, diazepam and meprobamate and showed significant reduction in the number of writhes and stretches. EEMS caused significant protection against pentylene tetrazole-induced convulsion and increased catecholamines and brain amino acids level significantly. Results showed that EEMS produced good CNS depressant effects in mice.

  14. [The federal participation law : New requirements for needs assessment with special emphasis on medical rehabilitation services].

    PubMed

    Schubert, Michael; Schian, Marcus; Viehmeier, Sarah

    2016-09-01

    The federal participation law (Bundesteilhabegesetz - BTHG) is one of the largest efforts in the last 15 years to reform the legal participation rights of people with disabilities. In particular, a number of enhancements are planned in the overall benefits law in Part 1 of Book IX in the Social Code (Sozialgesetzbuch - SGB), which applies to all rehabilitation carriers including general provisions and standards for needs assessment. This paper deals with the implications of these provisions and interacting standards, based on the draft bill of April 2016.The discussion takes place against the background of the regulatory objectives formulated in the ministerial draft itself, jurisprudential expertise on the effects of the current legal norms of the SGB IX as well as relevant professional political developments and statements by various stakeholders.The analysis shows a clear political commitment to increase the requirements for needs assessment in the overall law of the SGB IX and to express these more effectively. The draft bill seeks not only to modify procedures subsequent to the application for rehabilitation benefits, but also to precisely set out provisions on instruments for needs assessment in a new § 13. Common principles for these instruments of needs assessment should increase the cooperation, coordination and convergence among rehabilitation carriers.Nevertheless, with regard to the proposed regulatory texts, there is doubt that the objectives set by the draft bill itself will be achieved. For example, the required common principles for needs assessment are to be agreed upon based on the existing special legislation for the different rehabilitation carriers, without the SGB IX setting its own binding standards or framework principles. In addition, it lacks clear legal guidelines for the professional practice to make use of the bio-psycho-social model of the WHO and the ICF in the process of needs assessment. As a consequence the ICF cannot

  15. Managing Chronic Pain in Special Populations with Emphasis on Pediatric, Geriatric, and Drug Abuser Populations

    PubMed Central

    Baumbauer, Kyle M.; Young, Erin E.; Starkweather, Angela R.; Guite, Jessica W.; Russell, Beth S.; Manworren, Renee C.

    2015-01-01

    Synopsis Chronic pain represents a significant health and societal concern. In the adult population chronic pain can lead to loss of productivity, earning potential, and decreased quality of life. Research has typically focused on otherwise healthy adults with chronic pain conditions; however there appear to be distinct groups with increased vulnerability for the emergence of chronic pain. These groups may be defined by developmental status and/or life circumstances that increase the risk of injury or for which treatment of pain is less effective. Within the pediatric, geriatric, and drug abuser populations, chronic pain also represents a significant health issue, which can lead to increased absenteeism during school age years, as well as decreased quality of life and increased risk of additional adverse health conditions later in life. Currently, little is known about the mechanisms that encourage the development of chronic pain in these groups, and, consequently, pediatric, geriatric, and substance abuse patients represent challenging cohorts to manage. We focus on known anatomic, physiologic, and genetic mechanisms underlying chronic pain in these populations, and highlight the need for a multimodal approach from multiple healthcare professionals for management of chronic pain in those with the most risk. PMID:26614727

  16. [Achilles tendon rupture--early functional and surgical options with special emphasis on rehabilitation issues].

    PubMed

    Knobloch, K; Thermann, H; Hüfner, T

    2007-03-01

    Achilles tendon ruptures are one end of a continuum starting with the healthy Achilles tendon via the thickened and painful tendinopathic Achilles tendon with neovascularisation to the complete tendon rupture. Often times chinolone antibiotics, cortisone therapy and valgus foot axis are associated risk factors. Incidence of Achilles tendon ruptures is estimated to be 10/100 000 per year with a mean age of 35-40 years. Physical activity is encountered in 75 % cases of Achilles tendon ruptures. Running is associated with Achilles tendinopathy as the predominant overuse injury in an analysis among 291 athletes with 10 million kilometers exposure. The Achilles tendinopathic rate was 0.016/1000 km differentiated in 0.008/1000 km mid-portion tendinopathy and 0.005/1000 km insertional tendinopathy. Achilles tendinopathy in running overuse injuries is followed by runner's knee (0.013/1000 km), shin splint (0.0104/1000 km) and plantar fasciitis (0.0054/1000 km). Dynamic ultrasound in 20 degrees plantar flexion is of utmost importance for therapeutic decision making. With an adaptation rate of 75 % or more of the ruptured tendon in 20 degrees plantar flexion and a high patient's compliance we perform an early functional conservative treatment regimen in Achilles tendon ruptures. In almost all other cases the percutaneous Achilles tendon repair is indicated, where nervus suralis lesions have to be appreciated. The vulnerable zone is 10-12 cm proximal to the calcaneus at the lateral border of the Achilles tendon with the sural nerve in close proximity with the tendon. Early functional rehabilitation is not associated with a higher risk of rerupture but with improved subjective assessments and should therefore be advocated.

  17. Computational Age Dating of Special Nuclear Materials

    SciTech Connect

    None, None

    2012-06-30

    This slide-show presented an overview of the Constrained Progressive Reversal (CPR) method for computing decays, age dating, and spoof detecting. The CPR method is: Capable of temporal profiling a SNM sample; Precise (compared with known decay code, such a ORIGEN); Easy (for computer implementation and analysis). We have illustrated with real SNM data using CPR for age dating and spoof detection. If SNM is pure, may use CPR to derive its age. If SNM is mixed, CPR will indicate that it is mixed or spoofed.

  18. 20 CFR 404.383 - Special age 72 payment amounts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Special age 72 payment amounts. 404.383 Section 404.383 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Old-Age, Disability, Dependents' and Survivors' Insurance Benefits; Period...

  19. 20 CFR 404.383 - Special age 72 payment amounts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Special age 72 payment amounts. 404.383 Section 404.383 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Old-Age, Disability, Dependents' and Survivors' Insurance Benefits; Period...

  20. 20 CFR 404.383 - Special age 72 payment amounts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Special age 72 payment amounts. 404.383 Section 404.383 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Old-Age, Disability, Dependents' and Survivors' Insurance Benefits; Period...

  1. 20 CFR 404.383 - Special age 72 payment amounts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Special age 72 payment amounts. 404.383 Section 404.383 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Old-Age, Disability, Dependents' and Survivors' Insurance Benefits; Period...

  2. 20 CFR 404.383 - Special age 72 payment amounts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Special age 72 payment amounts. 404.383 Section 404.383 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Old-Age, Disability, Dependents' and Survivors' Insurance Benefits; Period...

  3. Current drug therapy of patients with BPH-LUTS with the special emphasis on PDE5 inhibitors

    PubMed Central

    Govorov, Alexander; Kasyan, George; Priymak, Diana; Pushkar, Dmitry

    2016-01-01

    Introduction Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptom (LUTS) development in men [1]. The intensity of the symptoms may vary from mild to severe, significantly affecting the quality of life. Erectile dysfunction (ED) is one of the most challenging issues in modern urology that significantly influences the quality of life in men worldwide. The objective of this literature review was to analyze the current drug therapies of patients with BPH-LUTS, with the special emphasis on PDE5 inhibitors. Material and methods The authors searched the literature for the period from 2000 until 2015 in MEDLINE and PubMed. Results Twenty-three articles were selected based on their reliability. A detailed analysis of the selected papers was performed. Primary attention was given to articles describing the use of PDE5. Works describing the use of different groups of drugs in patients with BPH-LUTS were also selected. Conclusions The current literature analysis suggests that the introduction of PDE5 inhibitors in clinical practice for the treatment of patients with BPH-LUTS will allow for significant expansion of the therapeutic options for the treatment of this disease. PMID:28127458

  4. Evolution, molecular epidemiology and perspectives on the research of taeniid parasites with special emphasis on Taenia solium.

    PubMed

    Bobes, Raúl J; Fragoso, Gladis; Fleury, Agnès; García-Varela, Martín; Sciutto, Edda; Larralde, Carlos; Laclette, Juan P

    2014-04-01

    Human cysticercosis is known since old historical times in Greece and China; however, human infections by tapeworms have accompanied human beings for more that hundred thousand years. The disease is tightly bound to poverty and lack of hygiene, and has been eradicated in developed countries, but continues being a public health problem in developing countries of Latin-American, Sub-Saharan Africa and Asia, and is also remerging in a number of non endemic countries. It is considered a neglected disease. Here we revise a number of key scientific contributions on taeniid biology that open new avenues for more effective approaches to the control of cysticercosis. The evolution of flatworms and class Cestoda is analyzed, with special emphasis on the emergence of taeniid parasites and the colonization of the human species by tapeworms. The complex molecular host-parasite interplay in this relationship as result of co-evolution between two distantly related organisms. The relevant host and parasite's factors, in the prospect of identifying species-specific molecular markers useful in epidemiological studies carried out in endemic countries. The new possibilities arising with the characterization of the genomes for several species of tapeworms, including a deeper understanding of these organisms, as well as improved tools for diagnosis, vaccination and drug treatment. The need to revise the current control and management strategies for this tropical neglected disease.

  5. Biogeography in Cellana (Patellogastropoda, Nacellidae) with Special Emphasis on the Relationships of Southern Hemisphere Oceanic Island Species.

    PubMed

    González-Wevar, Claudio A; Nakano, Tomoyuki; Palma, Alvaro; Poulin, Elie

    2017-01-01

    Oceanic islands lacking connections to other land are extremely isolated from sources of potential colonists and have acquired their biota mainly through dispersal from geographically distant areas. Hence, isolated island biota constitutes interesting models to infer biogeographical mechanisms of dispersal, colonization, differentiation, and speciation. Limpets of the genus Cellana (Nacellidae: Patellogastropoda) show limited dispersal capacity but are broadly distributed across the Indo-Pacific including many endemic species in isolated oceanic islands. Here, we examined main distributional patterns and geographic boundaries among Cellana lineages with special emphasis in the relationships of Southern Hemisphere oceanic islands species. Phylogenetic reconstructions based on mtDNA (COI) recognized three main clades in Cellana including taxa from different provinces of the Indo-Pacific. Clear genetic discontinuities characterize the biogeography of Cellana and several lineages are associated to particular areas of the Indo-Pacific supporting the low dispersal capacity of the genus across recognized biogeographical barriers in the region. However, evolutionary relationships within Cellana suggest that long-distance dispersal processes have been common in the history of the genus and probably associated to the origin of the species in Hawaii and Juan Fernández Archipelago. Therefore, the presence of Cellana species in geographically distant Southern Hemisphere oceanic islands, such as the Juan Fernández Archipelago, suggests that long-distance dispersal mediated by rafting may have played an important role in the biogeography of the genus.

  6. Reformulated and alternative fuels: modeled impacts on regional air quality with special emphasis on surface ozone concentration.

    PubMed

    Schell, Benedikt; Ackermann, Ingmar J; Hass, Heinz

    2002-07-15

    The comprehensive European Air Pollution and Dispersion model system was used to estimate the impacts of the usage of reformulated and alternative fuels on regional air quality with special emphasis on surface ozone concentrations. A severe western European summer smog episode in July 1994 has been used as a reference, and the model predictions have been evaluated for this episode. A forecast simulation for the year 2005 (TREND) has been performed, including the future emission development based on the current legislation and technologies available. The results of the scenario TREND are used as a baseline for the other 2005 fuel scenarios, including fuel reformulation, fuel sulfur content, and compressed natural gas (CNG) as an alternative fuel. Compared to the year 1994, significant reductions in episode peak ozone concentrations and ozone grid hours are predicted for the TREND scenario. These reductions are even more pronounced within the investigated alternative and reformulated fuel scenarios. Especially, low sulfur fuels are appropriate for an immediate improvement in air quality, because they effect the emissions of the whole fleet. Furthermore, the simulation results indicate that the introduction of CNG vehicles would also enhance air quality with respect to ozone.

  7. Overview of the physiology and pathophysiology of leptin with special emphasis on its role in the kidney.

    PubMed

    Nasrallah, Mona P; Ziyadeh, Fuad N

    2013-01-01

    The adipocyte product leptin is a pleiotropic adipokine and hormone, with a role extending beyond appetite suppression and increased energy expenditure. This review summarizes the biology of the leptin system and the roles of its different receptors in a multitude of cellular functions in different organs, with special emphasis on the kidney. Leptin's physiological functions as well as deleterious effects in states of leptin deficiency or hyperleptinemia are emphasized. Chronic hyperleptinemia can increase blood pressure through the sympathetic nervous system and renal salt retention. The concept of selective leptin resistance in obesity is emerging, whereby leptin's effect on appetite and energy expenditure is blunted, with a concomitant increase in leptin's other effects as a result of the accompanying hyperleptinemia. The divergence in response likely is explained by different receptors and post-receptor activating mechanisms. Chronic kidney disease is a known cause of hyperleptinemia. There is an emerging view that the effect of hyperleptinemia on the kidney can contribute to the development and/or progression of chronic kidney disease in selective resistance states such as in obesity or type 2 diabetes mellitus. The mechanisms of renal injury are likely the result of exaggerated and undesirable hemodynamic influences as well as profibrotic effects.

  8. Biogeography in Cellana (Patellogastropoda, Nacellidae) with Special Emphasis on the Relationships of Southern Hemisphere Oceanic Island Species

    PubMed Central

    Nakano, Tomoyuki; Palma, Alvaro; Poulin, Elie

    2017-01-01

    Oceanic islands lacking connections to other land are extremely isolated from sources of potential colonists and have acquired their biota mainly through dispersal from geographically distant areas. Hence, isolated island biota constitutes interesting models to infer biogeographical mechanisms of dispersal, colonization, differentiation, and speciation. Limpets of the genus Cellana (Nacellidae: Patellogastropoda) show limited dispersal capacity but are broadly distributed across the Indo-Pacific including many endemic species in isolated oceanic islands. Here, we examined main distributional patterns and geographic boundaries among Cellana lineages with special emphasis in the relationships of Southern Hemisphere oceanic islands species. Phylogenetic reconstructions based on mtDNA (COI) recognized three main clades in Cellana including taxa from different provinces of the Indo-Pacific. Clear genetic discontinuities characterize the biogeography of Cellana and several lineages are associated to particular areas of the Indo-Pacific supporting the low dispersal capacity of the genus across recognized biogeographical barriers in the region. However, evolutionary relationships within Cellana suggest that long-distance dispersal processes have been common in the history of the genus and probably associated to the origin of the species in Hawaii and Juan Fernández Archipelago. Therefore, the presence of Cellana species in geographically distant Southern Hemisphere oceanic islands, such as the Juan Fernández Archipelago, suggests that long-distance dispersal mediated by rafting may have played an important role in the biogeography of the genus. PMID:28099466

  9. Selenol protecting groups in organic chemistry: special emphasis on selenocysteine Se-protection in solid phase peptide synthesis.

    PubMed

    Flemer, Stevenson

    2011-04-18

    The appearance of selenium in organic synthesis is relatively rare, and thus examples in the literature pertaining to the masking of its considerable reactivity are similarly uncommon. Greene's Protecting Groups in Organic Synthesis, the standard reference for the state of the art in this arena, offers no entries for selenium protective methodology, in stark comparison to its mention of the great variety of protecting groups germane to its chalcogen cousin sulfur. This scarcity of Se-protection methods makes it no less interesting and pertinent toward the construction of selenium-containing organic systems which do indeed require the iterative blocking and de-blocking of selenol functionalities. A selenium-containing system which is especially relevant is selenocysteine, as its use in Solid Phase Peptide Synthesis requires extensive protection of its selenol side chain. This review will attempt to summarize the current state of understanding with regard to selenium protection protocol in organic synthesis. Moreover, it will provide a special emphasis on selenocysteine side chain protection, comprising both the breadth of functionality used for this purpose as well as methods of deprotection.

  10. Integrated plant nutrient system - with special emphasis on mineral nutriton and biofertilizers for Black pepper and cardamom - A review.

    PubMed

    K P, Sangeeth; R, Suseela Bhai

    2016-05-01

    Integrated Plant Nutrition System (IPNS) as a concept and farm management strategy embraces and transcends from single season crop fertilization efforts to planning and management of plant nutrients in crop rotations and farming systems on a long-term basis for enhanced productivity, profitability and sustainability. It is estimated that about two-thirds of the required increase in crop production in developing countries will have to come from yield increases from lands already under cultivation. IPNS enhances soil productivity through a balanced use of soil nutrients, chemical fertilizers, combined with organic sources of plant nutrients, including bio-inoculants and nutrient transfer through agro-forestry systems and has adaptation to farming systems in both irrigated and rainfed agriculture. Horticultural crops, mainly plantation crops, management practices include application of fertilizers and pesticides which become inevitable due to the depletion of soil organic matter and incidence of pests and diseases. The extensive use of chemical fertilizers in these crops deteriorated soil health that in turn affected the productivity. To revitalize soil health and to enhance productivity, it is inexorable to enrich the soil using microorganisms. The lacunae observed here is the lack of exploitation of indigenous microbes having the potential to fix atmospheric nitrogen (N) and to solubilize Phosphorus (P) and Potassium (K). The concept of biofertilizer application appears to be technically simple and financially feasible, but the task of developing biofertilizers with efficient strains in appropriate combinations in a consortia mode is not easier. More than developing consortia, a suitable delivery system to discharge the microbial inoculants warranted much effort. This review focuses on the integrated plant nutrition system incorporating biofertilizer with special emphasis on developing and formulating biofertilizer consortium.

  11. [Lipidic pattern of 25 Mexican marine fishes with special emphasis in their n-3 fatty acids as nutraceuticals components].

    PubMed

    Castro-González, María Isabel; Ojeda, Anayté; Silencio, José Luis; Cassis, Lorena; Ledesma, Hector; Pérez-Gil, Fernando

    2004-09-01

    The aim of this study was to characterize and to evaluate the lipidic composition of mexican marine fishes with special emphasis in n-3 fatty acids as nutraceuticals. The edible portion of 25 species: humidity (H), crude protein (CP), total lipids (TL) and fatty acids (FA). The average content (g/100g edible portion) of H was 75.20, PC was 18.40, TL was 3.60. Four n-3 FA were identified in all the samples and they were found in the next abundance order (mg/100g edible portion): C22:6n-3 (DHA)(229.60), C20:5 n-3 (EPA)(52.10), C18:3 n-3 (ALA)(11.80) and C20:3 n-3 (2.25). By their origin and climate there were no difference. By their biologycal classification, n-3 FA content was higher in bony fishes than cartilaginous fishes. It was detected a proportional relation with the n-3 FA concentration and total lipid content. According to their ecotic distribution there were numerical differences in DHA content (mg/100g edible portion) between pelagics (420.70), benthopelagics (125.30) and demersals fishes (225.40). Fatty fishes had higher content of EPA and DHA (mg/100g edible portion) (109.27 and 552.72) than semifatty fishes (56.12 and 226.29) and leanness (15.95 and 96.52), respectively. Bony, fatty and pelagic fishes had a higher content of EPA+DHA. According with the international recommendation values (200 to 600 mg EPA+DHA/day) the 44% of the analyzed species could be considered as functional foods due to their high content of EPA + DHA in a range of 220 to 1300 mg/100g.

  12. The pattern of antenatal visits with emphasis on gestational age at booking in Riyadh Health Centres.

    PubMed

    al-Shammari, S A; Khoja, T; Jarallah, J S

    1994-04-01

    1344 expectant mothers were selected by random sampling from the catchment population of 15 health centres in Riyadh. The health centres were taken to represent all areas of urban Riyadh. These mothers were asked to complete a pre-designed questionnaire in Arabic and undergo a structured interview by trained midwives to explore their knowledge, attitude and practice toward antenatal visits. It was found that the average gestational age at booking was 13 weeks. The number of antenatal visits achieved during the current pregnancy was 6. 97% of expectant mothers were aware of the importance of antenatal visits. Various demographic characteristics were studied in relation to the number of antenatal visits achieved and the gestational age at booking. It was found that the level of education of both husband and wife and poor obstetric history significantly affected gestational age at booking, (P-values) were less than 0.03 and 0.002 respectively). However the family income and gestational age at booking affected the number of antenatal visits (P-values were less than 0.0003 and 0.0001 respectively). The respondents' most striking reason for non-compliance was related to accessibility to health centre. 23.3% thought that the health centres were far away from their residence and they needed to involve the husbands in driving them to health centres. Recommendations were given to improve aspects of accessibility and inviting more antenatal visits in addition to improving quality of such service.

  13. Guide to National Data on Maternal and Child Health with Special Emphasis on Financing Services for Chronically Ill Children.

    ERIC Educational Resources Information Center

    McManus, Margaret A.; And Others

    The major purposes of this guide are to: (1) identify available national data on maternal and child health, with emphasis on costs of care and insurance coverage for chronically ill children; (2) explain to the reader how to use such data; and (3) offer recommendations for improving future collection and analysis of national data. The guide is…

  14. A Quantitative Analysis of Special Needs with Emphasis on Speech and Hearing in the Boston Public Schools.

    ERIC Educational Resources Information Center

    Wilson, Mazzie R.; Stewart, James Monroe

    1983-01-01

    The primary prototypes and educational goals used to educate Boston, Massachusetts, public school children with special needs (mainstreamed children) were analyzed and a demographic profile was developed. The results indicated that the special needs of the school children were not in close proportion to their racial distribution. (Author/SEW)

  15. Preparing Research Leaders for Special Education: A Ph.D. Program with an Emphasis in Applied Behavior Analysis.

    ERIC Educational Resources Information Center

    Heward, William L.; And Others

    1995-01-01

    An Ohio State University doctoral program for special education leadership personnel emphasizing applied behavior analysis is described. The program features intensive formal coursework, special topic seminars, participation in three research studies prior to dissertation, supervised college teaching and advising experiences, and a 10-week summer…

  16. Ontogeny of calbindin immunoreactivity in the human hippocampal formation with a special emphasis on granule cells of the dentate gyrus.

    PubMed

    Abrahám, Hajnalka; Veszprémi, Béla; Kravják, András; Kovács, Krisztina; Gömöri, Eva; Seress, László

    2009-04-01

    Calbindin (CB) is a calcium-binding protein that is present in principal cells as well as in interneurons of the hippocampal formation of various species including humans. Studies with transgenic mice revealed that CB is essential for long-term potentiation and synaptic plasticity which are the cellular basis of learning and memory. In a previous study we have shown that CB expression in granule cells of the dentate gyrus correlates with the functional maturation of the hippocampal formation in the rat. In the present study we examined the ontogeny of CB using immunohistochemistry in the human hippocampal formation paying special attention to the granule cells of the dentate gyrus. As early as the 14(th) week of gestation (GW), CB was being expressed by pyramidal cells of CA1-3 regions in the deepest cell rows of the pyramidal layer towards the ventricular zone. Later, CB sequentially appears in more superficial cell rows. After midgestation, CB disappears from CA3 pyramidal neurons. Expression of CB by granule cells starts at the 22(nd)-23(rd) GW, first by the most superficial neurons of the ectal end of the dorsal blade. At the 24(th) GW, CB is expressed by granule cells of the crest and medial portion of the ventral blade whereas later the entire ventral blade revealed CB immunoreactivity. At term, and in the first few postnatal months, CB-immunoreaction is detected in granule cells of both blades except for those neurons in the deepest cell rows at the hilar border. At around 2-3 years of age, all granule cells of the entire cell layer are CB-immunoreactive. Axons of granule cells, the mossy fibers, start to express CB around the 30(th) GW in stratum lucidum of CA3a. With further development, CB is expressed in CA3b and c, as well as in the hilus. An adult-like pattern of CB-immunoreactivity could be observed at 11 years of age. Our results indicate that (i) CB is expressed by hippocampal pyramidal cells a few weeks before midgestation; (ii) similarly to

  17. Current concepts in the recognition and classification of pain with special emphasis on orofacial pain: a review.

    PubMed

    Muriithi, A W; Chindia, M L

    1993-11-01

    Despite extensive investigation, pain cannot always be adequately diagnosed or cured. Subsequently, the management of pain can be daunting. The diagnosis of pain, however, is crucial to its effective management because of the grave influence that pain has on the quality of life. The biggest drawback in the management of pain is the lack of understanding, on the part of the practitioner, of the peripheral and central modulation of pain. The objective of this paper is to briefly review the current concepts in the recognition of and classification of pain, with emphasis on orofacial pain.

  18. Orientation to Trades and Technology. A Curriculum Guide and Resource Book with Special Emphasis on the Needs of Women. Revised.

    ERIC Educational Resources Information Center

    Braundy, Marcia

    This combination curriculum guide and resource book was developed in response to recommendations made by the instructors who attended the Women in Trades and Technology (WITT) conference of June 1986. It assists in the design and delivery of exploratory trade and technology courses that are responsive to the special needs of women learners…

  19. 75 FR 5601 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... Aging Special Emphasis Panel, Alzheimer's Disease Genetics. Date: March 4, 2010. Time: 7:30 p.m. to 8:30... Institute on Aging Special Emphasis Panel, Drug Development for Alzheimer's Disease. Date: March 10,...

  20. 42 CFR 408.45 - Deduction from age 72 special payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Deduction from age 72 special payments. 408.45... § 408.45 Deduction from age 72 special payments. (a) Deduction of premiums. SMI premiums are deducted from age 72 special payments made under section 228 of the Act or the payments are withheld...

  1. 42 CFR 408.45 - Deduction from age 72 special payments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Deduction from age 72 special payments. 408.45... § 408.45 Deduction from age 72 special payments. (a) Deduction of premiums. SMI premiums are deducted from age 72 special payments made under section 228 of the Act or the payments are withheld...

  2. 42 CFR 408.45 - Deduction from age 72 special payments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Deduction from age 72 special payments. 408.45... § 408.45 Deduction from age 72 special payments. (a) Deduction of premiums. SMI premiums are deducted from age 72 special payments made under section 228 of the Act or the payments are withheld...

  3. 42 CFR 408.45 - Deduction from age 72 special payments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Deduction from age 72 special payments. 408.45... § 408.45 Deduction from age 72 special payments. (a) Deduction of premiums. SMI premiums are deducted from age 72 special payments made under section 228 of the Act or the payments are withheld...

  4. Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake.

    PubMed

    Uribarri, Jaime

    2007-01-01

    Elevated serum phosphorus has been identified as a cardiovascular risk factor in chronic kidney disease (CKD) patients and a clear understanding of phosphorus homeostasis is very important for practicing nephrologists. At any particular point, serum phosphorus levels reflect the balance between movements of this mineral from and into the intestine, bone, intracellular space, and kidneys. We briefly review here all these exchanges with a particular emphasis on dietary phosphorus intake. Despite all the oral phosphorus binders currently available in the market, dietary restriction of this mineral remains a cornerstone for the prevention and treatment of hyperphosphatemia. An effective restriction of dietary intake of phosphorus requires prescription of a moderate protein intake (0.9-1.0 g/kg/day) and restricted consumption of highly processed fast and convenience foods. Phosphorus added during food processing is an important source of this mineral because of its magnitude and high bioavailabilty. Moreover, as food manufacturers are not required to label the amount of phosphorus added during food processing, a significant amount of the current daily phosphorus intake remains unaccounted when estimating phosphorus intake in CKD patients. The recent development of low phosphorus-containing food products represents a very useful addition for CKD patients.

  5. Phytoplankton dynamics with a special emphasis on harmful algal blooms in the Mar Piccolo of Taranto (Ionian Sea, Italy).

    PubMed

    Caroppo, Carmela; Cerino, Federica; Auriemma, Rocco; Cibic, Tamara

    2016-07-01

    The response of phytoplankton assemblages to the closure of urban sewage outfalls (USOs) was examined for the Mar Piccolo of Taranto (Mediterranean Sea), a productive semi-enclosed coastal marine ecosystem devoted to shellfish farming. Phytoplankton dynamics were investigated in relation to environmental variables, with a particular emphasis on harmful algal blooms (HABs). Recent analyses evidenced a general reduction of the inorganic nutrient loads, except for nitrates and silicates. Also phytoplankton biomass (chlorophyll a) and abundances were characterized by a decrease of the values, except for the inner area of the basin (second inlet). The phytoplankton composition changed, with nano-sized species, indicators of oligotrophic conditions, becoming dominant over micro-sized species. If the closure of the USOs affected phytoplankton dynamics, however, it did not preserve the Mar Piccolo from HABs and anoxia crises. About 25 harmful species have been detected throughout the years, such as the potentially domoic acid producers Pseudo-nitzschia cf. galaxiae and P seudo-nitzschia cf. multistriata, identified for the first time in these waters. The presence of HABs represents a threat for human health and aquaculture. Urgent initiatives are needed to improve the communication with authorities responsible for environmental protection, economic development, and public health for a sustainable mussel culture in the Mar Piccolo.

  6. Seasonal dynamics of zooplankton in Columbia–Snake River reservoirs,with special emphasis on the invasive copepod Pseudodiaptomus forbesi

    USGS Publications Warehouse

    Emerson, Joshua E.; Bollens, Stephen M.; Counihan, Timothy D.

    2015-01-01

    The Asian copepod Pseudodiaptomus forbesi has recently become established in the Columbia River. However, little is known about its ecology and effects on invaded ecosystems. We undertook a 2-year (July 2009 to June 2011) field study of the mesozooplankton in four reservoirs in the Columbia and Snake Rivers, with emphasis on the relation of the seasonal variation in distribution and abundance of P. forbesi to environmental variables. Pseudodiaptomus forbesi was abundant in three reservoirs; the zooplankton community of the fourth reservoir contained no known non-indigenous taxa. The composition and seasonal succession of zooplankton were similar in the three invaded reservoirs: a bloom of rotifers occurred in spring, native cyclopoid and cladoceran species peaked in abundance in summer, and P. forbesi was most abundant in late summer and autumn. In the uninvaded reservoir, total zooplankton abundance was very low year-round. Multivariate ordination indicated that temperature and dissolved oxygen were strongly associated with zooplankton community structure, with P. forbesi appearing to exhibit a single generation per year . The broad distribution and high abundance of P. forbesi in the Columbia–Snake River System could result in ecosystem level effects in areas intensively managed to improve conditions for salmon and other commercially and culturally important fish species. 

  7. A process-based model of conifer forest structure and function with special emphasis on leaf lifespan

    NASA Astrophysics Data System (ADS)

    Osborne, Colin P.; Beerling, David J.

    2002-12-01

    We describe the University of Sheffield Conifer Model (USCM), a process-based approach for simulating conifer forest carbon, nitrogen, and water fluxes by up-scaling widely applicable relationships between leaf lifespan and function. The USCM is designed to predict and analyze the biogeochemistry and biophysics of conifer forests that dominated the ice-free high-latitude regions under the high pCO2 "greenhouse" world 290-50 Myr ago. It will be of use in future research investigating controls on the contrasting distribution of ancient evergreen and deciduous forests between hemispheres, and their differential feedbacks on polar climate through the exchange of energy and materials with the atmosphere. Emphasis is placed on leaf lifespan because this trait can be determined from the anatomical characteristics of fossil conifer woods and influences a range of ecosystem processes. Extensive testing of simulated net primary production and partitioning, leaf area index, evapotranspiration, nitrogen uptake, and land surface energy partitioning showed close agreement with observations from sites across a wide climatic gradient. This indicates the generic utility of our model, and adequate representation of the key processes involved in forest function using only information on leaf lifespan, climate, and soils.

  8. Buoyancy-generating agents for stomach-specific drug delivery: an overview with special emphasis on floating behavior.

    PubMed

    Ishak, Rania A H

    2015-01-01

    Gastric retentive drug delivery provides a promising technology exhibiting an extended gastric residence and a drug release independent of patient related variables. It is usually useful in improving local gastric treatment as well as overcoming drug-related problems .i.e. drugs having narrow absorption window, short half-life or low intestinal solubility. Buoyancy is considered one of the most promising approaches for gastro-retention of dosage forms. Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach causing an increase in gastric residence time. The buoyancy of these systems is attained by the aid of substances responsible to generate the low density. Various agents with different mechanisms were adopted either gas-generating agents, air entrapping swellable polymers, inherent low density substances, porous excipients, hollow/porous particles inducing preparation techniques or sublimating agents. Therefore, this review gives an exclusive descriptive classification of the different categories of these buoyancy-generating agents while representing the related research works. An overview is also conducted to describe relevant techniques assessing the floating behavior of such dosage forms either in vitro or in vivo. Finally, a collection representing FDA-approved floating pharmaceutical products is adopted with emphasis on the buoyancy-generating agent type used in each product.

  9. Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells.

    PubMed

    Manda, Katrin; Glasow, Annegret; Paape, Daniel; Hildebrandt, Guido

    2012-01-01

    Dendritic cells (DCs), as professional antigen-presenting cells, are members of the innate immune system and function as key players during the induction phase of adaptive immune responses. Uptake, processing, and presentation of antigens direct the outcome toward either tolerance or immunity. The cells of the immune system are among the most highly radiosensitive cells in the body. For high doses of ionizing radiation (HD-IR) both immune-suppressive effects after whole body irradiation and possible immune activation during tumor therapy were observed. On the other hand, the effects of low doses of ionizing radiation (LD-IR) on the immune system are controversial and seem to show high variability among different individuals and species. There are reports revealing that protracted LD-IR can result in radioresistance. But immune-suppressive effects of chronic LD-IR are also reported, including the killing or sensitizing of certain cell types. This article shall review the current knowledge of radiation-induced effects on the immune system, paying special attention to the interaction of DCs and T cells.

  10. Missing data: a special challenge in aging research.

    PubMed

    Hardy, Susan E; Allore, Heather; Studenski, Stephanie A

    2009-04-01

    Scientific evidence should guide clinical care, but special methodological challenges influence interpretation of the medical literature pertaining to older adults. Missing data, ranging from lack of individual items in questionnaires to complete loss to follow-up, affect the quality of the evidence and are more likely to occur in studies of older adults because older adults have more health and functional problems that interfere with all aspects of data collection than do younger people. The purpose of this article is to promote knowledge about the risks and consequences of missing data in clinical aging research and to provide an organized approach to prevention and management. Although it is almost never possible to achieve complete data capture, efforts to prevent missing data are more effective than analytical "cure." Strategies to prevent missing data include selecting a primary outcome that is easy to determine and devising valid alternate definitions, adapting data collection to the special needs of the target population, pilot testing data collection plans, and monitoring missing data rates during the study and adapting data collection procedures as needed. Key steps in the analysis of missing data include assessing the extent and types of missing data before analysis, exploring potential mechanisms that contributed to the missing data, and using multiple analytical approaches to assess the effect of missing data on the results. Manuscripts should disclose rates of missing data and losses to follow-up, compare dropouts with participants who completed the study, describe how missing data were managed in the analysis phase, and discuss the potential effect of missing data on the conclusions of the study.

  11. Inference, simulation, modeling, and analysis of complex networks, with special emphasis on complex networks in systems biology

    NASA Astrophysics Data System (ADS)

    Christensen, Claire Petra

    's own publications have contributed network inference, simulation, modeling, and analysis methods to the much larger body of work in systems biology, and indeed, in network science. The aim of this thesis is therefore twofold: to present this original work in the historical context of network science, but also to provide sufficient review and reference regarding complex systems (with an emphasis on complex networks in systems biology) and tools and techniques for their inference, simulation, analysis, and modeling, such that the reader will be comfortable in seeking out further information on the subject. The review-like Chapters 1, 2, and 4 are intended to convey the co-evolution of network science and the slow but noticeable breakdown of boundaries between disciplines in academia as research and comparison of diverse systems has brought to light the shared properties of these systems. It is the author's hope that theses chapters impart some sense of the remarkable and rapid progress in complex systems research that has led to this unprecedented academic synergy. Chapters 3 and 5 detail the author's original work in the context of complex systems research. Chapter 3 presents the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B.subtilis from experimentally obtained, yet mathematically underdetermined microchip array data. These networks are then analyzed from a graph theoretical perspective, and their biological viability is critiqued by comparing the networks' graph theoretical properties to those of other biological systems. The results of topological perturbation analyses revealing commonalities in behavior at multiple levels of complexity are also presented, and are shown to be an invaluable means by which to ascertain the level of complexity to which the network inference process is robust to noise. Chapter 5 outlines a learning algorithm for the development of a realistic, evolving social

  12. Heavy metal concentrations in soils as determined by laser-induced breakdown spectroscopy (LIBS), with special emphasis on chromium.

    PubMed

    Senesi, G S; Dell'Aglio, M; Gaudiuso, R; De Giacomo, A; Zaccone, C; De Pascale, O; Miano, T M; Capitelli, M

    2009-05-01

    Soil is unanimously considered as one of the most important sink of heavy metals released by human activities. Heavy metal analysis of natural and polluted soils is generally conducted by the use of atomic absorption spectroscopy (AAS) or inductively coupled plasma optical emission spectroscopy (ICP-OES) on adequately obtained soil extracts. Although in recent years the emergent technique of laser-induced breakdown spectroscopy (LIBS) has been applied widely and with increasing success for the qualitative and quantitative analyses of a number of heavy metals in soil matrices with relevant simplification of the conventional methodologies, the technique still requires further confirmation before it can be applied fully successfully in soil analyses. The main objective of this work was to demonstrate that new developments in LIBS technique are able to provide reliable qualitative and quantitative analytical evaluation of several heavy metals in soils, with special focus on the element chromium (Cr), and with reference to the concentrations measured by conventional ICP spectroscopy. The preliminary qualitative LIBS analysis of five soil samples and one sewage sludge sample has allowed the detection of a number of elements including Al, Ca, Cr, Cu, Fe, Mg, Mn, Pb, Si, Ti, V and Zn. Of these, a quantitative analysis was also possible for the elements Cr, Cu, Pb, V and Zn based on the obtained linearity of the calibration curves constructed for each heavy metal, i.e., the proportionality between the intensity of the LIBS emission peaks and the concentration of each heavy metal in the sample measured by ICP. In particular, a triplet of emission lines for Cr could be used for its quantitative measurement. The consistency of experiments made on various samples was supported by the same characteristics of the laser-induced plasma (LIP), i.e., the typical linear distribution confirming the existence of local thermodynamic equilibrium (LTE) condition, and similar excitation

  13. Modifications to an interactive model of the human body during exercise: With special emphasis on thermoregulation. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Scherb, Megan Kay

    1993-01-01

    Since 1988 an interactive computer model of the human body during exercise has been under development by a number of undergraduate students in the Department of Chemical Engineering at Iowa State University. The program, written under the direction of Dr. Richard C. Seagrave, uses physical characteristics of the user, environmental conditions and activity information to predict the onset of hypothermia, hyperthermia, dehydration, or exhaustion for various levels and durations of a specified exercise. The program however, was severely limited in predicting the onset of dehydration due to the lack of sophistication with which the program predicts sweat rate and its relationship to sensible water loss, degree of acclimatization, and level of physical training. Additionally, it was not known whether sweat rate also depended on age and gender. For these reasons, the goal of this creative component was to modify the program in the above mentioned areas by applying known information and empirical relationships from literature. Furthermore, a secondary goal was to improve the consistency with which the program was written by modifying user input statements and improving the efficiency and logic of the program calculations.

  14. Efficacy of micafungin in invasive candidiasis caused by common Candida species with special emphasis on non-albicans Candida species.

    PubMed

    Cornely, Oliver A; Vazquez, Jose; De Waele, Jan; Betts, Robert; Rotstein, Coleman; Nucci, Marcio; Pappas, Peter G; Ullmann, Andrew J

    2014-02-01

    The incidence of invasive candidiasis caused by non-albicans Candida (NAC) spp. is increasing. The aim of this analysis was to evaluate the efficacy of micafungin, caspofungin and liposomal amphotericin B in patients with invasive candidiasis and candidaemia caused by different Candida spp. This post hoc analysis used data obtained from two randomised phase III trials was conducted to evaluate the efficacy and safety of micafungin vs. caspofungin and micafungin vs. liposomal amphotericin B. Treatment success, clinical response, mycological response and mortality were evaluated in patients infected with C. albicans and NAC spp. Treatment success rates in patients with either C. albicans or NAC infections were similar. Outcomes were similar for micafungin, caspofungin and liposomal amphotericin B. Candida albicans was the most prevalent pathogen recovered (41.0%), followed by C. tropicalis (17.9%), C. parapsilosis (14.4%), C. glabrata (10.4%), multiple Candida spp. (7.3%) and C. krusei (3.2%). Age, primary diagnosis (i.e. candidaemia or invasive candidiasis), previous corticosteroid therapy and Acute Physiology and Chronic Health Evaluation II score were identified as potential predictors of treatment success and mortality. Micafungin, caspofungin and liposomal amphotericin B exhibit favourable treatment response rates that are comparable for patients infected with different Candida spp.

  15. Disability pension among young women in Sweden, with special emphasis on family structure: a dynamic cohort study

    PubMed Central

    Hagman, Maud; Aronsson, Gunnar; Gustafsson, Klas; Marklund, Staffan; Wikman, Anders

    2012-01-01

    Objectives The influence of family structure on the risk of going on disability pension (DP) was investigated among young women by analysing a short-term and long-term effect, controlling for potential confounding and the ‘healthy mother effect’. Design and participants This dynamic cohort study comprised all women born in Sweden between 1960 and 1979 (1.2 million), who were 20–43 years of age during follow-up. Their annual data were retrieved from national registers for the years 1993–2003. For this period, data on family structure and potential confounders were related to the incidence of DP the year after the exposure assessment. Using a modified version of the COX proportional hazard regression, we took into account changes in the study variables of individuals over the years. In addition, a 5-year follow-up was used. Results Cohabiting working women with children showed a decreased risk of DP in a 1-year perspective compared with cohabiting working women with no children, while the opposite was indicated in the 5-year follow-up. Lone working women with children had an increased risk of DP in both the short-term and long-term perspective. The risk of DP tended to increase with the number of children for both cohabiting and lone working women in the 5-year follow-up. Conclusions The study suggests that parenthood contributes to increasing the risk of going on DP among young women, which should be valuable knowledge to employers and other policy makers. It remains to be analysed to what extent the high numbers of young women exiting from working life may be counteracted by (1) extended gender equality, (2) fewer work hours among fathers and mothers of young children and (3) by financial support to lone women with children. PMID:22649174

  16. Developmental Screening and Assessment Instruments with an Emphasis on Social and Emotional Development for Young Children Ages Birth through Five

    ERIC Educational Resources Information Center

    Ringwalt, Sharon, Comp.

    2008-01-01

    In recent years, there has been a growing emphasis on the mental health and social and behavioral developmental needs of very young children. In response, state administrators and local providers of early intervention and preschool programs have worked to strengthen their screening and assessment of children's social and emotional development. The…

  17. 78 FR 21960 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Committee: National Institute on Aging Special Emphasis Panel; Presenilins and Alzheimer's Disease. Date..., PARSADANIANA@NIA.NIH.GOV . Name of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's... Special Emphasis Panel; Alzheimer's Disease Prevention. Date: July 11, 2013. Time: 12 p.m. to 1...

  18. Maine Department of Education Regulation 180: Early Intervention and Special Education for Children Age Birth to under Age Six.

    ERIC Educational Resources Information Center

    Maine State Dept. of Education, Augusta.

    This document contains regulations governing the administration of the Childfind system for children age birth to under age 6, the provision of early intervention services to eligible children birth through two with disabilities and their families, and the provision of special education and related services to eligible children age 3 to under 6…

  19. How Special Education Preschool Graduates Finish: Status at 19 Years of Age

    ERIC Educational Resources Information Center

    Jenkins, Joseph R.; Dale, Philip S.; Mills, Paulette E.; Cole, Kevin N.

    2006-01-01

    This article reports the academic and special education status of 129 graduates of special education preschools at 19 years of age. Participants had been randomly assigned to either direct instruction or mediated learning preschool classrooms. At age 19, their achievement was approximately one standard deviation below average. Consistent with…

  20. Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.

    PubMed

    Tardío, Juan C; Pinedo, Fernando; Aramburu, José Antonio; Martínez-González, Miguel Á; Arias, Dolores; Khedaoui, Radia; Suárez-Massa, Dolores; Santonja, Carlos

    2016-08-01

    Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review the literature with special emphasis on the differential diagnosis. The clear cell variant represents 5% of AFX from their files. Histopathologically, it consists of sheets of epithelioid, pleomorphic cells, intermixed with a varying number of giant multinucleated and spindle cells, the latter arranged in a fascicular pattern. All cell types predominantly exhibit a clear, microvacuolated cytoplasm with well-demarcated cell borders. The clinical and immunohistochemical features of this variant are similar to those of the classic type. Clear cell AFX must be differentiated from other cutaneous clear cell neoplasms, some of them with an aggressive clinical behavior, including clear cell melanoma, primary cutaneous and metastatic clear cell carcinomas, clear cell sarcoma, pleomorphic liposarcoma, tumor of perivascular epithelioid cells, and distinctive dermal clear cell mesenchymal neoplasm. The clinical presentation and immunohistochemical profile play a key role in the differential diagnosis.

  1. The fine structure of the midgut epithelium in a centipede, Scolopendra cingulata (Chilopoda, Scolopendridae), with the special emphasis on epithelial regeneration.

    PubMed

    Chajec, Lukasz; Sonakowska, Lidia; Rost-Roszkowska, Magdalena M

    2014-01-01

    Scolopendra cingulata has a tube-shaped digestive system that is divided into three distinct regions: fore-, mid- and hindgut. The midgut is lined with a pseudostratified columnar epithelium which is composed of digestive, secretory and regenerative cells. Hemocytes also appear between the digestive cells of the midgut epithelium. The ultrastructure of three types of epithelial cells and hemocytes of the midgut has been described with the special emphasis on the role of regenerative cells in the protection of midgut epithelium. The process of midgut epithelium regeneration proceeds due to the ability of regenerative cells to proliferate and differentiate according to a circadian rhythm. The regenerative cells serve as unipotent stem cells that divide in an asymmetric manner. Additionally, two types of hemocytes have been distinguished among midgut epithelial cells. They enter the midgut epithelium from the body cavity. Because of the fact that numerous microorganisms occur in the cytoplasm of midgut epithelial cells, we discuss the role of hemocytes in elimination of pathogens from the midgut epithelium. The studies were conducted with the use of transmission electron microscope and immunofluorescent methods.

  2. Specialized Meaninglessness: A Source of Truth in the Technical Age.

    ERIC Educational Resources Information Center

    Thompson, Mark E.

    This essay discusses how technical processes can deceive us and how college educators and social scientists must be especially sensitive to the dangers of technology when conducting research and proposing applications from research. As technology and bureaucratic controls have grown, so too have the demands for specialized knowledge in many areas.…

  3. Special Report: Vocational Training in the High-Tech Age.

    ERIC Educational Resources Information Center

    Mansnerus, Laura; And Others

    1994-01-01

    "New Pressures on Vocational Education" (Mansnerus) describes new forms (tech prep, career academies, apprenticeship, school enterprises); "Biotechnology Goes to High School" (Quinn) describes Berkeley High's Biotech Academy created by industry; and "Votech That Works" (Holusha) stresses the importance of specialized training for non-college-bound…

  4. The Special Value of Children's Age-Mixed Play

    ERIC Educational Resources Information Center

    Gray, Peter

    2011-01-01

    From an evolutionary perspective, the normal social play of children involves kids of various ages. Our human and great-ape ancestors most likely lived in small groups with low birth rates, which made play with others of nearly the same age rare. Consequently, the evolutionary functions of children's social play are best understood by examining…

  5. Twenty-six-week oral toxicity of diheptyl phthalate with special emphasis on its induction of liver proliferative lesions in male F344 rats.

    PubMed

    Nakane, Fumiyuki; Kunieda, Masaki; Shimizu, Shigekazu; Kobayashi, Yoshihiko; Akane, Hirotoshi; Akie, Yasuki; Saito, Akemi; Noguchi, Masayoshi; Kadota, Toshihito; Mitsumori, Kunitoshi

    2012-01-01

    The 26-week oral toxicity of diheptyl phthalate (DHP), a peroxisome proliferator-activated receptor α (PPARα) agonist, with special emphasis on the potential induction of hepatocellular proliferative lesions was investigated in this study. DHP was administered to male F344 rats via gavage at 0 (control), 1,000 or 2,000 mg/kg/day for 26 weeks. Body weight gain was significantly lower, whereas food and water consumption was significantly higher in DHP-treated rats compared with controls. DHP-treated rats exhibited decreases in blood triglyceride, total cholesterol, phospholipid and glucose levels, which were likely related to biological effects of the PPARα agonist. Absolute and relative organ weights of the livers with pale brown discoloration and dark brown spots significantly increased in DHP-treated rats. Histopathological examinations revealed remarkable diffuse hypertrophy of hepatocytes with ground-glass appearance, intracytoplasmic inclusion bodies and/or vacuolation in the DHP-treated groups. These findings were associated with increases in serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and γ-glutamyltranspeptidase. The number and area of glutathione S-transferase placental form positive foci, a marker of hepatocellular preneoplastic lesions in rats, significantly increased in DHP-treated groups. Additionally, proliferating cell nuclear antigen positive liver cell counts in DHP-treated groups were significantly higher than those of the controls. Testicular alterations were not detected histopathologically, whereas absolute and relative prostate weights significantly decreased at both doses. These results indicate that DHP induces liver pre-neoplastic foci, and suggest the possibility that DHP is a possible genotoxic carcinogen in the liver of rats.

  6. Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex.

    PubMed

    Legaz, Isabel; Olmos, Luis; Real, M Angeles; Guirado, Salvador; Dávila, José Carlos; Medina, Loreta

    2005-08-08

    We studied the development of neurons and fibers containing calbindin, calretinin, and parvalbumin in the mouse pallial amygdala, with special emphasis on those of the basolateral amygdalar complex. Numerous calbindin-immunoreactive (CB+) cells were observed in the incipient basolateral amygdalar complex and cortical amygdalar area from E13.5. At E16.5, CB+ cells became more abundant in the lateral and basolateral nuclei than in the basomedial nucleus, showing a pattern very similar to that of gamma-aminobutyric acid (GABA)ergic neurons. Many CB+ cells observed in the pallial amygdala appeared to originate in the anterior entopeduncular area/ganglionic eminences of the subpallium. The density of CB+ cells gradually increased in the pallial amygdala until the first postnatal week and appeared to decrease later, coinciding with the postnatal appearance of parvalbumin cells and raising the possibility of a partial phenotypic shift. Calretinin (CR) immunoreactivity could be observed in a few cells and fibers in the pallial amygdala at E14.5, and by E16.5 it became a good marker of the different nuclei of the basolateral amygdalar complex. Numerous CB+ and CR+ varicosities, part of which have an intrinsic origin, were observed in the basolateral amygdalar complex from E16.5, and some surrounded unstained perikarya and/or processes before birth, indicating an early formation of inhibitory networks. Each calcium binding protein showed a distinct spatiotemporal expression pattern of development in the mouse pallial amygdala. Any alteration in the development of neurons and fibers containing calcium binding proteins of the pallial amygdala may result in important disorders of emotional and social behavior.

  7. Graduates' Perspectives on a National Specialized Program in Social Work and Aging

    ERIC Educational Resources Information Center

    Greenfield, Emily A.; Shpiegel, Svetlana

    2012-01-01

    Recognizing the growing need for social workers with specialized training in aging, the Hartford Partnership Program for Aging Education (HPPAE) has developed as a nationwide initiative to enhance aging education for master's-level social work students. This study presents a content analysis of answers to 2 open-ended questions in a national…

  8. Functional Curriculum for Elementary, Middle, and Secondary Age Students with Special Needs. Second Edition

    ERIC Educational Resources Information Center

    Wehman, Paul; Kregel, John

    2004-01-01

    The second edition of Functional Curriculum for Elementary, Middle, and Secondary Age Students with Special Needs has an expanded framework for a functional and longitudinal curriculum for children and adolescents with disabilities and other special needs. These is a stronger demand than ever to provide a curriculum with everyday usefulness and…

  9. Organization of the dorsocaudal neostriatal complex: a retrograde and anterograde tracing study in the domestic chick with special emphasis on pathways relevant to imprinting.

    PubMed

    Metzger, M; Jiang, S; Braun, K

    1998-06-08

    In the forebrain of domestic chicks, a network of distinct regions is crucially involved in auditory and visual filial imprinting. Among these areas, a distinct part of the dorsocaudal neostriatal complex (dNC complex), termed neostriatum dorsocaudale (Ndc), was recently discovered by its enhanced metabolic activity during the presentation of auditory and visual imprinting stimuli. Since there is evidence that the dNC complex consists of several distinct functional subareas, we investigated the neural connections of different parts of the dNC complex by retro- and anterograde pathway tracing. Special emphasis was put on the connections of the dNC complex with other imprinting relevant regions in the rostral telencephalon, such as the mediorostral neostriatum/hyperstriatum ventrale (MNH) and the intermediate and medial part of the hyperstriatum ventrale (IMHV). By anterograde and multiple retrograde pathway tracing, we found that the dNC complex may at least be subdivided into three major constituents. The most medial part of the dNC complex, termed neostriatum dorsale (Nd), is characterized by strong reciprocal connections with the neostriatal part of the MNH and by its auditory related inputs, including those from the output layers L1 and L3 of field L, and the shell region of the thalamic n. ovoidalis. The Ndc, which occupies the central aspects of the dNC complex, is mainly characterized by reciprocal connections with the ectostriatal belt (Ep) and the adjacent neostriatum (N). Furthermore, Nd and Ndc receive strong thalamic input from the n. dorsolateralis posterior (DLP), both project to the IMHV, and both are reciprocally connected with the archistriatum intermedium (AI). The most lateral aspect of the dNC complex, termed Ndl, is characterized by afferents from the neostriatum frontale, pars trigeminalis (NFT), and by the lack of a thalamic input. Results indicate that the dNC complex comprises distinct subregions, which are characterized by their specific

  10. Disabled or Young? Relative Age and Special Education Diagnoses in Schools

    ERIC Educational Resources Information Center

    Dhuey, Elizabeth; Lipscomb, Stephen

    2010-01-01

    This study extends recent findings of a relationship between the relative age of students among their peers and their probability of disability classification. Using three nationally representative surveys spanning 1988-2004 and grades K-10, we find that an additional month of relative age decreases the likelihood of receiving special education…

  11. Mortality and morbidity in the city of Bern, Switzerland, 1805-1815 with special emphasis on infant, child and maternal deaths.

    PubMed

    Rüttimann, D; Loesch, S

    2012-02-01

    This article contributes to the research on demographics and public health of urban populations of preindustrial Europe. The key source is a burial register that contains information on the deceased, such as age and sex, residence and cause of death. This register is one of the earliest compilations of data sets of individuals with this high degree of completeness and consistency. Critical assessment of the register's origin, formation and upkeep promises high validity and reliability. Between 1805 and 1815, 4,390 deceased inhabitants were registered. Information concerning these individuals provides the basis for this study. Life tables of Bern's population were created using different models. The causes of death were classified and their frequency calculated. Furthermore, the susceptibility of age groups to certain causes of death was established. Special attention was given to causes of death and mortality of newborns, infants and birth-giving women. In comparison to other cities and regions in Central Europe, Bern's mortality structure shows low rates for infants (q0=0.144) and children (q1-4=0.068). This could have simply indicated better living conditions. Life expectancy at birth was 43 years. Mortality was high in winter and spring, and decreased in summer to a low level with a short rise in August. The study of the causes of death was inhibited by difficulties in translating early 19th century nomenclature into the modern medical system. Nonetheless, death from metabolic disorders, illnesses of the respiratory system, and debilitation were the most prominent causes in Bern. Apparently, the worst killer of infants up to 12 months was the "gichteren", an obsolete German term for lethal spasmodic convulsions. The exact modern identification of this disease remains unclear. Possibilities such as infant tetanus or infant epilepsy are discussed. The maternal death rate of 0.72% is comparable with values calculated from contemporaneous sources. Relevance of

  12. Postmortem Aging of Beef with a Special Reference to the Dry Aging.

    PubMed

    Khan, Muhammad I; Jung, Samooel; Nam, Ki Chang; Jo, Cheorun

    2016-01-01

    Animal muscles are stored for specific period (aging) at refrigerated temperatures, during and after which the living muscles start to convert into meat and thus, attain certain superior properties in the final product. Proteolysis, lipolysis, and oxidation are the major biochemical processes involved during the postmortem aging of meat that affect the tenderness, juiciness, and flavor, as well as sometimes may introduce certain undesirable traits. This review analyzes the role of pre- and post-mortem factors that are important for aging and their effect on the chemical and physical changes in the "dry- and wet-aged meat." Thus, if the meat processing manufacturers optimize the effects of aging for specific muscles, the palatability, color, and the shelf life of the aged meat products could be significantly enhanced.

  13. Postmortem Aging of Beef with a Special Reference to the Dry Aging

    PubMed Central

    Khan, Muhammad I.; Jung, Samooel; Nam, Ki Chang; Jo, Cheorun

    2016-01-01

    Animal muscles are stored for specific period (aging) at refrigerated temperatures, during and after which the living muscles start to convert into meat and thus, attain certain superior properties in the final product. Proteolysis, lipolysis, and oxidation are the major biochemical processes involved during the postmortem aging of meat that affect the tenderness, juiciness, and flavor, as well as sometimes may introduce certain undesirable traits. This review analyzes the role of pre- and post-mortem factors that are important for aging and their effect on the chemical and physical changes in the “dry- and wet-aged meat.” Thus, if the meat processing manufacturers optimize the effects of aging for specific muscles, the palatability, color, and the shelf life of the aged meat products could be significantly enhanced. PMID:27194923

  14. [The organization and quality of specialized hospital care of early age children].

    PubMed

    2012-01-01

    The article considers the quality of specialized hospital care of early age children based on the materials of 568 records of hospital patients in the Republican children hospital of Makhachkala. The important imperfections are detected. About 30% of patients suffered from untimely and insufficient treatment. The untimely consultations took place in case of 15.6% of patients. About 22% of patients didn't receive a whole course of treatment needed. The comprehensive treatment of children was not applied in fullness at the discharge from the hospital in 14% of patients. The guidelines to enhance the quality of specialized hospital care of early age children are developed.

  15. National survey on edentulism and its geographic distribution, among Mexicans 18 years of age and older (with emphasis in WHO age groups).

    PubMed

    Medina-Solís, C E; Pérez-Núñez, R; Maupomé, G; Avila-Burgos, L; Pontigo-Loyola, A P; Patiño-Marín, N; Villalobos-Rodelo, J J

    2008-04-01

    To determine the prevalence of edentulism in adults aged 18 years and older in Mexico and to describe its distribution in 20 of the 32 States in Mexico, highlighting the experience in the WHO age groups. A secondary analysis of the National Performance Evaluation Survey 2002-2003 (representative at the state level and part of the Word Health Survey) was undertaken. The sample design was probabilistic, stratified and through conglomerates. Data on dental conditions were available only for 20 of the 32 states of Mexico, leading to a total of 24 159 households (N = 54 638 654). The percentage of edentulism was determined as the proportion of subjects that self-reported complete loss of teeth. Data were analyzed using the SVY module for complex surveys in STATA 8.2. The mean age was 41.3 +/- 17.0 years (range 18-99). An estimated 6.3% (N = 3 437 816) of the population > or =18 years was edentulous. Lowest prevalences were observed in the states of Tlaxcala, Puebla and the Estado de Mexico with 3.4%, 3.8% and 4.5%, respectively. Highest prevalences were observed in San Luis Potosí, Colima, and Michoacán with 10.3%, 10.2% and 10.1%, respectively. Following the WHO age groups, the prevalence ranged from 2.4% in the 35-44 group through 25.5% in the 65-74 group. No obvious association between socio-economic and socio-demographic indicators at the state level and prevalence of edentulism was found. The prevalence of complete tooth loss observed in the present study varied greatly across states, although no straightforward association was found with socio-economic and socio-demographic indicators at the state level. This study could serve as a baseline to enable future evaluations of the oral status of Mexican adults and elders, following WHO age groups.

  16. 77 FR 40368 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Age, Gene/Environment Susceptibility... evaluate contract proposals. Place: National Institute on Aging, Gateway Building, 7201 Wisconsin...

  17. 75 FR 61766 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ..., Aging Research, National Institutes of Health, HHS) Dated: September 30, 2010. Jennifer S. Spaeth... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Cartilage Aging and Osteoarthritis....

  18. Specialized Science

    PubMed Central

    Fang, Ferric C.

    2014-01-01

    As the body of scientific knowledge in a discipline increases, there is pressure for specialization. Fields spawn subfields that then become entities in themselves that promote further specialization. The process by which scientists join specialized groups has remarkable similarities to the guild system of the middle ages. The advantages of specialization of science include efficiency, the establishment of normative standards, and the potential for greater rigor in experimental research. However, specialization also carries risks of monopoly, monotony, and isolation. The current tendency to judge scientific work by the impact factor of the journal in which it is published may have roots in overspecialization, as scientists are less able to critically evaluate work outside their field than before. Scientists in particular define themselves through group identity and adopt practices that conform to the expectations and dynamics of such groups. As part of our continuing analysis of issues confronting contemporary science, we analyze the emergence and consequences of specialization in science, with a particular emphasis on microbiology, a field highly vulnerable to balkanization along microbial phylogenetic boundaries, and suggest that specialization carries significant costs. We propose measures to mitigate the detrimental effects of scientific specialism. PMID:24421049

  19. Problem of ticks and tick-borne diseases in India with special emphasis on progress in tick control research: a review.

    PubMed

    Ghosh, Srikant; Nagar, Gaurav

    2014-12-01

    Ticks, as vectors of several zoonotic diseases, are ranked second only to mosquitoes as vectors. The diseases spread by ticks are a major constraint to animal productivity while causing morbidity and mortality in both animals and humans. A number of tick species have been recognised since long as vectors of lethal pathogens, viz. Crimean-Congo haemorrhagic fever virus (CCHFV), Kyasanur forest disease virus (KFDV), Babesia spp, Theileria, Rickettsia conorii, Anaplasma marginale, etc. and the damages caused by them are well-recognised. There is a need to reassess the renewed threat posed by the tick vectors and to prioritize the tick control research programme. This review is focused on the major tick-borne human and animal diseases in India and the progress in vector control research with emphasis on acaricide resistance, tick vaccine and the development of potential phytoacaricides as an integral part of integrated tick control programme.

  20. Exercise rehabilitation for peripheral artery disease: An exercise physiology perspective with special emphasis on the emerging trend of home-based exercise.

    PubMed

    Gardner, Andrew W

    2015-11-01

    Peripheral artery disease (PAD) is a significant medical concern that is highly prevalent, costly, and deadly. Additionally, patients with PAD have significant impairments in functional independence and health-related quality of life due to leg symptoms and ambulatory dysfunction. Exercise therapy is a primary treatment for patients with PAD, as ambulatory outcome measures improve following a program of exercise rehabilitation. This review describes the outcomes that improve with exercise, the potential mechanisms for improved leg symptoms, key exercise program considerations for training patients with PAD with walking-based exercise, other exercise modalities that have been utilised, the use of on-site supervised exercise programs, and a major focus on historical and contemporary trials on conducting home-based, minimally supervised exercise program to treat PAD. The review concludes with recommendations for future exercise trials, with particular emphasis on reported greater details of the exercise prescription to more accurately quantify the total exercise dose of the program.

  1. Cluster Headache: Special Considerations for Treatment of Female Patients of Reproductive Age and Pediatric Patients.

    PubMed

    VanderPluym, Juliana

    2016-01-01

    Cluster headache is a rare disorder that is more common in adult male patients. It has a unique phenotype of unilateral, severe, to very severe headaches lasting 15 to 180 min with ipsilateral autonomic symptoms. Time to correct diagnosis can be protracted. A number of treatment options exist for the standard cluster headache patient, but special considerations must be made for female patients of reproductive age and pediatric patients. The objective of this article is to explore the current literature pertaining to special considerations in cluster headache management, including treatment of pregnant or breastfeeding patients and pediatric patients.

  2. Genetic characterization and phylogenetic analysis of skunk-associated rabies viruses in North America with special emphasis on the central plains.

    PubMed

    Davis, Rolan; Nadin-Davis, Susan A; Moore, Michael; Hanlon, Cathleen

    2013-06-01

    Across North America the skunk acts as a reservoir for several rabies virus variants. Some of these variants are geographically restricted in range as is the case for the California skunk variant and two distinct variants present in Mexico. In contrast the North Central and South Central skunk rabies viruses are dispersed in overlapping ranges over large areas of the Midwestern region of the United States with the former extending into southern parts of the Canadian prairies. Despite this extensive range, there has been only very limited molecular characterization of these two viral variants. This study has examined the genetic diversity of the rabies viruses associated with North American skunks, with particular emphasis on the South Central skunk variant which was found to comprise three distinct geographically restricted groups of viruses that could in some cases be further sub-divided. The phylogenetic relationships of these groups and sub-groups allowed us to infer the likely direction of spread of these variants in some instances. Patterns of amino acid replacement of North American skunk-associated rabies viruses for both the nucleoprotein and glycoprotein products are also examined. These patterns reflect the virus phylogeny but no amino acid residues associated specifically with the skunk host were identified.

  3. Spectrum of Sickle Cell Diseases in Patients Diagnosed at a Tertiary Care Centre in Karnataka with Special Emphasis on their Clinicohaematological Profile

    PubMed Central

    Lokanatha, Hemalata; Ramachandrappa, Rajashekar Murthy G

    2016-01-01

    Introduction Sickle cell disease is a monogenic disorder with considerable clinical diversity and Sickle haemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anaemia, frequency of crises and duration of survival. As they are confused with many other clinically aggressive disorders, precision in diagnosis is essential both to proper clinical management and subsequent genetic counselling. Hence, this study was taken up in order to diagnose these conditions and administer suitable counselling measures to minimise the incidence of sickle cell disease in the future. Aim The aim of this study was to identify the spectrum of all Sickle cell diseases diagnosed at a tertiary care centre in Bangalore, Karnataka, India who presented over a period of five years from 2009 to 2013 and also to screen the parents and siblings of the patients for their carrier status. Materials and Methods We reviewed 26 cases of Sickle Cell Disease (SCD) and also 38 parents & 10 siblings of these children for their carrier status. Haemoglobin electrophoreses was performed by using alkaline gel method, followed by High Performance Liquid Chromatography when needed. Results A total of 26 children diagnosed with SCD were enrolled in the study. Most common entity was Sickle Cell Anaemia (SCA), followed by sickle thalassaemia and Sickle Cell Trait (SCT). Commonest clinical presentation was fever and pallor. Amongst the parents and siblings, sickle cell trait was the most common entity followed by thalassaemia trait. One interesting case of HbSE disease was encountered, which is a rare entity in India. Conclusion This study brings out the total spectrum of SCDs in a tertiary care centre in Karnataka, with more emphasis on screening of the parents and siblings for their carrier status. PMID:27042470

  4. 77 FR 9670 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Prevention. Date: March 1, 2012...., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  5. 77 FR 50704 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Drug Development for Alzheimer's Disease... applications. Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite...

  6. 75 FR 4829 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Development and Maintenance of a... contract proposals. Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Ave, Suite...

  7. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Development and Maintenance of a... and evaluate contract proposals. Place: National Institute on Aging, Gateway Building, 7201...

  8. A survey on regenerative surgery performed by Swiss specialists in periodontology with special emphasis on the application of enamel matrix derivatives in infrabony defects.

    PubMed

    Schröen, Ola; Sahrmann, Philipp; Roos, Malgorzata; Attin, Thomas; Schmidlin, Patrick R

    2011-01-01

    This survey aimed to evaluate the common practice of regenerative periodontal surgery with special regard to the use of enamel matrix derivatives (EMD, Emdogain® ) by board-certified specialists in periodontology and non-certified, but active members of the Swiss Society of Periodontology (SSP). A cross-sectional postal survey of 533 dentists, representing all members of the SSP practising in Switzerland, was conducted. The questionnaire consisted of three sections, assessing: 1) general personal information regarding the practice setting and education, 2) general questions regarding periodontal surgery practices and 3) specific questions regarding the use of EMD. The information obtained was compared and differences between specialists and non-specialists were calculated. P-values smaller than 5% were considered significant. Sixty-nine percent of the specialists answered the questionnaire, compared to only 37.4% of the non-specialists (overall: 42.4%). In general, specialists performed surgeries more frequently, and presented a significantly higher percentage of EMD users than the non-specialists. The application guidelines were followed in general. Some differences were observed in application and selection criteria. The subjective perception of clinical success varied greatly among clinicians. Residual pockets were reported to be present in approximately one third of the defects after therapy. In conclusion, this survey revealed that EMD was used on a regular basis by dentists performing periodontal therapy. In addition, the answers by both groups generally corresponded well with the current available literature.

  9. Differential diagnosis of adrenal mass using imaging modality: special emphasis on f-18 fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography.

    PubMed

    Lee, Hong Je; Lee, Jaetae

    2014-03-01

    Adrenal incidentalomas are adrenal masses serendipitously detected during an imaging study performed for reasons unrelated to suspicion of adrenal disease. The incidence of adrenal incidentalomas has increased because of the widespread use of various imaging modalities. In oncology patients with adrenal incidentalomas, the characterization of the adrenal masses is challenging because nearly 50% of incidental adrenal masses are metastatic lesions that need special medical attention. Although unenhanced computed tomography (CT) densitometry, chemical shift magnetic resonance imaging (MRI), delayed contrast-enhanced CT and CT histogram analysis have been used as sensitive and specific modalities for differentiating benign from malignant adrenal masses, F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET)/CT is a highly accurate imaging modality compared to CT or MRI, especially when these two imaging modalities are combined. In addition, a semiquantitative analysis using standardized uptake value ratio further improves the diagnostic accuracy of F-18 FDG PET/CT in differentiating benign from malignant adrenal masses. Thus, F-18 FDG PET/CT is very helpful for determining the best therapeutic management, especially for assessing the need for surgery.

  10. Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation

    PubMed Central

    Fung, Peter Chin Wan

    2009-01-01

    This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis) for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. Acupuncture acting on meridian channel causes cytoskeletal remodeling through mechanotransduction, leading to regulation of gene expression and the subsequent production of related proteins. Also, stimulation on cell surface can trigger Ca2+ activities, resulting in a cascade of intra- and inter-cellular signaling. Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. Acupoint along a meridian channel is a functional site to trigger the above functions with specificity and high efficiency. PMID:19480699

  11. Distribution of immunoreactive glutamine synthetase in the adult human and mouse brain. Qualitative and quantitative observations with special emphasis on extra-astroglial protein localization.

    PubMed

    Bernstein, Hans-Gert; Bannier, Jana; Meyer-Lotz, Gabriela; Steiner, Johann; Keilhoff, Gerburg; Dobrowolny, Henrik; Walter, Martin; Bogerts, Bernhard

    2014-11-01

    Glutamine synthetase catalyzes the ATP-dependent condensation of ammonia and glutamate to form glutamine, thus playing a pivotal role in glutamate and glutamine homoeostasis. Despite a plethora of studies on this enzyme, knowledge about the regional and cellular distribution of this enzyme in human brain is still fragmentary. Therefore, we mapped fourteen post-mortem brains of psychically healthy individuals for the distribution of the glutamine synthetase immunoreactive protein. It was found that glutamine synthetase immunoreactivity is expressed in multiple gray and white matter astrocytes, but also in oligodendrocytes, ependymal cells and certain neurons. Since a possible extra-astrocytic expression of glutamine synthetase is highly controversial, we paid special attention to its appearance in oligodendrocytes and neurons. By double immunolabeling of mouse brain slices and cultured mouse brain cells for glutamine synthetase and cell-type-specific markers we provide evidence that besides astrocytes subpopulations of oligodendrocytes, microglial cells and neurons express glutamine synthetase. Moreover, we show that glutamine synthetase-immunopositive neurons are not randomly distributed throughout human and mouse brain, but represent a subpopulation of nitrergic (i.e. neuronal nitric oxide synthase expressing) neurons. Possible functional implications of an extra-astrocytic localization of glutamine synthetase are discussed.

  12. [Impact of commuting on partnership and family life. A literature review of the current state of research with special emphasis on commuter marriages].

    PubMed

    Häfner, Steffen

    2011-01-01

    Because of modern working conditions, for many people commuting has increasingly become a necessity with many consequences for their health as well as for their family life and partnership. To date, little research has been done concerning the impact of this modern lifestyle on partnership and family life, particularly on dual-career couples and long-distance commuters. The results of a literature review are presented based on age, sex, family cycle and consequences for children; research questions are formulated. Sex-specific differences seem to be especially important, confirming the "household responsibility hypothesis." The commuter marriage as a new lifestyle seems to have become a coping mechanism for the increasing necessity in our society to commute.

  13. Hereditary angioedema: special consideration in children, women of childbearing age, and the elderly.

    PubMed

    Kuhlen, James L; Banerji, Aleena

    2015-01-01

    This review on hereditary angioedema (HAE) focused on special topics regarding HAE in children, women of childbearing age, and the elderly. HAE is a rare autosomal dominant bradykinin-mediated disorder characterized by recurrent attacks of subcutaneous or submucosal swelling that usually affects the face, upper airway, extremities, gastrointestinal tract, or genitalia. These recurrent attacks cause significant morbidity and can be life threatening, especially when the swelling affects the airway. Our objective was to summarize the published data available on the disease epidemiology, pathophysiology, clinical presentation, on demand and prophylactic therapy, and focus on management considerations for these special patient populations. Unique aspects of HAE in women with regard to contraception, hormone replacement therapy, pregnancy, lactation, and menopause were also reviewed.

  14. Prevalence of intestinal parasitic infections among children under five years of age with emphasis on Schistosoma mansoni in Wonji Shoa Sugar Estate, Ethiopia.

    PubMed

    G/hiwot, Yirgalem; Degarege, Abraham; Erko, Berhanu

    2014-01-01

    Intestinal parasite infections are major public health problems of children in developing countries causing undernutrition, anemia, intestinal obstruction and mental and physical growth retardation. This study was conducted to assess the prevalence of intestinal helminthic infections among children under five years of age with emphasis on Schistosoma mansoni in Wonji Shoa Sugar Estate, Ethiopia. A cross-sectional parasitological survey was conducted in under-five children living in Wonji Shoa Sugar Estate Ethiopia, April, 2013. Stool samples were collected and examined for intestinal parasites using single Kato-Katz and single Sodium acetate-acetic acid-formalin (SAF) solution concentration methods. Out of 374 children examined using single Kato-Katz and single SAF-concentration methods, 24.3% were infected with at least one intestinal parasite species. About 10.4%, 8.8%, 4.6%, 2.9%, 1.6% and 0.8% of the children were infected with Hymenolepis nana, Schistosoma mansoni, Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis and hookworm, respectively. Prevalence of double, triple and quadruple intestinal helminthic infection was 6.4%, 0.54% and 1.1%, respectively. A significant increase in prevalence of S. mansoni (8.3% versus 3.2%) and T. trichiura (2.7% versus 0.5%) infection was observed when determined via the single Kato-Katz method compared to the prevalence of the parasites determined via the single SAF-concentration method. On the other hand, the single SAF-concentration method (9.1%) revealed a significantly higher prevalence of H. nana infection than the single Kato-Katz (1.6%) does. In conclusion, intestinal helminths infections particularly S. mansoni and H. nana were prevalent in under-five children of Wonji Shoa Sugar Estate. Including praziquantel treatment in the deworming program as per the World Health Organization guidelines would be vital to reduce the burden of these diseases in areas where S. mansoni and H. nana infections are

  15. Modelling multi-species interactions in the Barents Sea ecosystem with special emphasis on minke whales and their interactions with cod, herring and capelin

    NASA Astrophysics Data System (ADS)

    Lindstrøm, Ulf; Smout, Sophie; Howell, Daniel; Bogstad, Bjarte

    2009-10-01

    The Barents Sea ecosystem, one of the most productive and commercially important ecosystems in the world, has experienced major fluctuations in species abundance the past five decades. Likely causes are natural variability, climate change, overfishing and predator-prey interactions. In this study, we use an age-length structured multi-species model (Gadget, Globally applicable Area-Disaggregated General Ecosystem Toolbox) to analyse the historic population dynamics of major fish and marine mammal species in the Barents Sea. The model was used to examine possible effects of a number of plausible biological and fisheries scenarios. The results suggest that changes in cod mortality from fishing or cod cannibalism levels have the largest effect on the ecosystem, while changes to the capelin fishery have had only minor effects. Alternate whale migration scenarios had only a moderate impact on the modelled ecosystem. Indirect effects are seen to be important, with cod fishing pressure, cod cannibalism and whale predation on cod having an indirect impact on capelin, emphasising the importance of multi-species modelling in understanding and managing ecosystems. Models such as the one presented here provide one step towards an ecosystem-based approach to fisheries management.

  16. Essential and nonessential elements in nestling rooks Corvus frugilegus from eastern Poland with a special emphasis on their high cadmium contamination.

    PubMed

    Orłowski, Grzegorz; Kamiński, Piotr; Kasprzykowski, Zbigniew; Zawada, Zbigniew; Koim-Puchowska, Beata; Szady-Grad, Małgorzata; Klawe, Jacek J

    2012-11-01

    Concentration of minerals (sodium, potassium, calcium [Ca], magnesium, iron [Fe], copper, zinc [Zn], manganese [Mn], and cobalt) as well as toxic metals (cadmium [Cd], lead [Pb]) were determined in five tissues (liver, lung, kidney, muscle, and bone) of nestling rooks (Corvus frugilegus; 1 to 13 days old) found dead in seven breeding colonies in eastern Poland. Cd concentration in all analyzed tissues was in the narrow range of 17.0-17.2 mg/kg dry weight (dw) Cd, which in the light of the literature data indicates acute contamination by this toxic metal. Similarly, we found increased levels of Pb, which in all tissues ranged between 5.0 and 6.2 mg/kg dw. Results of multivariate general linear model (GLM) testing of the effect of three variables (tissue type, colony, and nestling age) on tissue concentrations of various metals showed significance for Fe, Cu, Zn, and Mn. Only concentrations of Ca, Fe, and Zn differed significantly between the analyzed tissues. GLM analysis did not show any statistically significant differences in tissue levels of minerals and both toxic metals among examined rookeries, which indicates the widespread presence of nonpoint Cd and Pb pollution linked to agricultural activity and similar levels of these inorganic contaminants on crop fields (feeding grounds) around breeding colonies. We concluded that high levels of both toxic metals, Cd and Pb, probably resulting from the diet of nestling rooks, are based mainly on a diet of ground-dwelling beetles gathered on crop fields.

  17. International collaborative research on infectious diseases by Japanese universities and institutes in Asia and Africa, with a special emphasis on J-GRID.

    PubMed

    Shinoda, Sumio; Imamura, Daisuke; Mizuno, Tamaki; Miyoshi, Shin-Ichi; Ramamurthy, Thandavrayan

    2015-01-01

    In developed countries including Japan, malignant tumor (cancer), heart disease and cerebral apoplexy are major causes of death, but infectious diseases are still responsible for a high number of deaths in developing countries, especially among children aged less than 5 years. World Health Statistics published by WHO reports a high percentage of mortality from infectious diseases in children, and many of these diseases may be subject to transmission across borders and could possibly invade Japan.  Given this situation, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan initiated Phase I of the Program of Founding Research Centers for Emerging and Reemerging Infectious Disease, which ran from FY 2005 to 2009, and involved 8 Japanese universities and 2 research centers. The program was established for the following purposes: 1) creation of a domestic research structure to promote the accumulation of fundamental knowledge about infectious diseases, 2) establishment of 13 overseas research collaboration centers in 8 countries at high risk of emerging and reemerging infections and at which Japanese researchers are stationed and conduct research in partnership with overseas instructors, 3) development of a network among domestic and overseas research centers, and 4) development of human resources.  The program was controlled under MEXT and managed by the RIKEN Center of Research Network for Infectious Diseases (Riken CRNID). Phase II of the program was set up as the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID), and has been running in FY 2010-2014.  Phase III will start in April 2015, and will be organized by the newly established Japanese governmental organization "Japan Agency for Medical Research and Development (AMED)", the so-called Japanese style NIH.  The Collaborative Research Center of Okayama University for Infectious Diseases in India (CRCOUI) was started up in 2007 at the National

  18. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of...

  19. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of...

  20. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR No. 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of...

  1. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of...

  2. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR No. 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of...

  3. 76 FR 28236 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ..., parsadaniana@nia.nih.gov . Name of Committee: National Institute on Aging Special Emphasis Panel, Oxidative Stress and Aging. Date: July 13, 2011. Time: 12 p.m. to 4 p.m. Agenda: To review and evaluate...

  4. 78 FR 5189 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... Committee: National Institute on Aging Special Emphasis Panel; Circadian Clocks and Aging: Molecular... Sleep Cycle II. Date: March 4, 2013. Time: 12:00 p.m. to 4:00 p.m. Agenda: To review and evaluate...

  5. 75 FR 26969 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... . Name of Committee: National Institute on Aging Special Emphasis Panel; Protein Quality Control. Date... patentable material, and personal information concerning individuals associated with the grant applications... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892 (Telephone...

  6. [Present possibilities of age determination in forensic medicine with emphasis on the importance of measurement of D- and L- forms of aspartic acid. I. An overview].

    PubMed

    Pilin, A; Pudil, F; Gross, R; Herrmannová, M

    1997-02-01

    Evaluation of age of unknown deceased persons belongs to the most important ways to identification. For the time being, morphological methods are used, namely evaluation of age according to Gustafson's method from tooth grindings or by macroscopical estimation of abrasion, transparency of root dentine, alveolar atrophy and number of missing teeth. Evaluation of the data can be influenced by an individual failure and experience showed an age related decrease of precision. Recently, some papers occurred estimating a relation of D, L-forms of aspartic acid which depends on the age with a significant precision.

  7. Special education services and school performance in a regional cohort of low-birthweight infants at age nine.

    PubMed

    Pinto-Martin, Jennifer; Whitaker, Agnes; Feldman, Judith; Cnaan, Avital; Zhao, Huaqing; Bloch, Joan Rosen; Rosen-Bloch, Joan; McCulloch, Dawn; Paneth, Nigel

    2004-03-01

    Previous research has shown that low birthweight is a predictor of several adverse educational outcomes, including special educational placement, by middle school age. Most low-birthweight follow-up studies that have extended to school age have focused on very small infants-- < 1500 or < 1000 g; less is known of the school age outcomes for infants with only moderately low birthweight (1500-2000 g). This study examines the prevalence of special educational placement and the relationship of such placement to grade retention, verbal and performance scores on tests of general intelligence, reading and maths achievement scores and classroom hyperactivity among low-birthweight children. In a regional birth cohort of 1105 infants born between 1984 and 1987 and weighing 500-2000 g, 868 children were available for follow-up at age nine. Information on special education placement as well as grade retention, intelligence, academic achievement and classroom behaviour was available on 645 (74% completion rate). Nearly a third of the cohort was classified as needing special education. Special education placement followed a birthweight gradient, occurring among 29.3% of children with birthweights 1500-2000 g, among 32.5% in children 1000-1500 g and 49.4% in children < 1000 g. Among children in special education, a similar birthweight gradient was found for maths achievement and hyperactivity, but not for reading achievement or IQ scores. Among children not in special education, only maths achievement showed such a decline with birthweight. A substantial proportion of low-birthweight children, including those of moderate low birthweight, receive special education services, although the need is greatest among those with the lowest birthweights. Maths achievement declined with birthweight regardless of educational placement. The medical and social risk factors that accompany low birthweight and may account for these findings, require further study.

  8. Post Information Age Positioning for Special Librarians: Is Knowledge Management the Answer?

    ERIC Educational Resources Information Center

    Abram, Stephen

    1997-01-01

    Argues that special librarians are not fact keepers but "catalysts in the knowledge continuum." Examines special librarians, the information business, and knowledge management; the knowledge continuum (data, information, knowledge, behavior) and strategies for successful "transformational librarianship": organizing information,…

  9. Developments in Aging: 1974 and January-April 1975. A Report of the Special Committee on Aging. United States Senate Pursuant to S. Res. 267, March 1, 1974.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    The Special Committee on Aging, established in 1961 by Senate Resolution 33, Eighty-seventh Congress, was charged with making a full and complete study and investigation of problems and opportunities of older people, including problems and opportunities of maintaining health, of assuring adequate income, of finding employment, of engaging in…

  10. Developments in Aging: 1986. Volume 1. A Report of the Special Committee on Aging. United States Senate, One Hundredth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document is the first volume of a two-volume Senate report describing actions taken during 1986 by the Congress, the administration, and the Senate Special Committee on Aging which are significant to older Americans. It summarizes and analyzes federal policies and programs that are of continuing importance for older persons and their…

  11. Wisdom-related knowledge in a life review task: age differences and the role of professional specialization.

    PubMed

    Staudinger, U M; Smith, J; Baltes, P B

    1992-06-01

    The study adopts life review as an avenue to access wisdom-related knowledge and examines the contribution of age and type of professional specialization to individual differences in wisdom-related knowledge. Women from 2 age groups/cohorts (young, M = 32 years; old, M = 71 years) and different professional specializations (human services vs. nonhuman services) were asked to think aloud about the life review of a fictitious woman who was either young or old. Verbal protocols were scored on 5 wisdom-related criteria: factual and procedural knowledge about life, life-span contextualism, relativism of values, recognition, and management of uncertainty. Three major findings emerged. First, human-services professionals outperformed the control group. Second, old adults performed as well as young adults. Third, for older adults wisdom-related performance was enhanced by the match between their own age and the age of the fictitious character.

  12. The Special Nature of the Outdoors: Its Contribution to the Education of Children Aged 3-11

    ERIC Educational Resources Information Center

    Waite, Sue; Davis, Bernie; Rea, Tony

    2006-01-01

    There are many forms of outdoor learning. In the UK outdoor adventures, residential centres, field studies, Forest School and play in the outdoors are all available to some extent for the three to eleven age group. Each type has distinct aims and purposes but there are however some commonalities which may point to what the special nature of the…

  13. Medicare: Catastrophic Illness Insurance. Briefing Report to the Chairman, Special Committee on Aging, U.S. Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Program Evaluation and Methodology Div.

    In response to a request by Senator John Melcher of the United States Senate Special Committee on Aging, the General Accounting Office (GAO) reviewed legislative proposals designed to protect Medicare enrollees from the financial hardships that often accompany catastrophic illness. The GAO originally examined six legislative proposals introduced…

  14. Age-related changes in bone strength from HR-pQCT derived microarchitectural parameters with an emphasis on the role of cortical porosity.

    PubMed

    Vilayphiou, Nicolas; Boutroy, Stephanie; Sornay-Rendu, Elisabeth; Van Rietbergen, Bert; Chapurlat, Roland

    2016-02-01

    The high resolution peripheral computed tomography (HR-pQCT) technique has seen recent developments with regard to the assessment of cortical porosity. In this study, we investigated the role of cortical porosity on bone strength in a large cohort of women. The distal radius and distal tibia were scanned by HR-pQCT. We assessed bone strength by estimating the failure load by microfinite element analysis (μFEA), with isotropic and homogeneous material properties. We built a multivariate model to predict it, using a few microarchitecture variables including cortical porosity. Among 857 Caucasian women analyzed with μFEA, we found that cortical and trabecular properties, along with the failure load, impaired slightly with advancing age in premenopausal women, the correlations with age being modest, with |rage| ranging from 0.14 to 0.38. After the onset of the menopause, those relationships with age were stronger for most parameters at both sites, with |rage| ranging from 0.10 to 0.64, notably for cortical porosity and failure load, which were markedly deteriorated with increasing age. Our multivariate model using microarchitecture parameters revealed that cortical porosity played a significant role in bone strength prediction, with semipartial r(2)=0.22 only at the tibia in postmenopausal women. In conclusion, in our large cohort of women, we observed a small decline of bone strength at the tibia before the onset of menopause. We also found an age-related increase of cortical porosity at both scanned sites in premenopausal women. In postmenopausal women, the relatively high increase of cortical porosity accounted for the decline in bone strength only at the tibia.

  15. 76 FR 21386 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Organelle Lifespan Mechanism II. Date: June... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892...

  16. 76 FR 65203 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging ACTION: Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Mechanisms of Osteoporosis II. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  17. Geologic Reconnaissance of the Antelope-Ashwood Area, North-Central Oregon: With Emphasis on the John Day Formation of Late Oligocene and Early Miocene Age

    USGS Publications Warehouse

    Peck, Dallas L.

    1964-01-01

    This report briefly describes the geology of an area of about 750 square miles in Jefferson, Wasco, Crook, and Wheeler Counties, Oregon. About 16,000 feet of strata that range in age from pre-Tertiary to Quaternary are exposed. These include the following units: pre-Tertiary slate, graywacke, conglomerate, and meta-andesite; Clarno Formation of Eocene age - lava flows, volcanic breccia, tuff, and tuffaceous mudstone, chiefly of andesitic composition; John Day Formation of late Oligocene and early Miocene age - pyroclastic rocks, flows, and domes, chiefly of rhyolitic composition; Columbia River Basalt of middle Miocene age - thick, columnar jointed flows of very fine grained dense dark-gray basalt; Dalles Formation of Pliocene age - bedded tuffaceous sandstone, siltstone, and conglomerate; basalt of Pliocene or Pleistocene age - lava flows of porous-textured olivine basalt; and Quaternary loess, landslide debris, and alluvium. Unconformities separate pre-Tertiary rocks and Clarno Formation, Clarno and John Day Formations, John Day Formation and Columbia River Basalt, and Columbia River Basalt and Dalles Formation. The John Day Formation, the only unit studied in detail, consists of about 4,000 feet of tuff, lapilli tuff, strongly to weakly welded rhyolite ash flows, and less abundant trachyandesite flows and rhyolite flows and domes. The formation was divided into nine mappable members in part of the area, primarily on the basis of distinctive ledge-forming welded ash-flow sheets. Most of the sheets are composed of stony rhyolite containing abundant lithophysae and sparse phenocrysts. One sheet contains 10 to 20 percent phenocrysts, mostly cryptoperthitic soda sanidine, but including less abundant quartz, myrmekitic intergrowths of quartz and sanidine, and oligoclase. The rhyolitic ash flows and lava flows were extruded from nearby vents, in contrast to some of the interbedded air-fall tuff and lapilli tuff of dacitic and andesitic composition that may have been

  18. Beta-haemolytic streptococci in school children 5-15 years of age with an emphasis on rheumatic fever, in the tri-island state of Grenada.

    PubMed

    Noel, T P; Zabriskie, J; Macpherson, C N L; Perrotte, G

    2005-01-01

    The objective of this study is to determine the prevalence of beta-haemolytic streptococci in the pharynx and antibodies to beta-haemolytic streptococci in school children 5-15 years of age in the tri-island state of Grenada Blood samples and throat swabs were obtained from 1388 school children, aged 5-15 years old attending randomly selected schools in each parish of the tri-island state of Grenada. Serum samples were subjected to antistreptolysin o testing (ASOT) while throat swabs were cultured on sheep blood agar plates. The prevalence of positive throat swab was 15.4% (95% CI = 13.4%, 17.2%). The rate was highest in St Patrick (21.8%) and lowest in Carriacou (5.7%). The prevalence of antibodies was 38.6% (95% CI = 37.6%, 42.8%). It was highest in St Patrick (54.4%) and lowest in Petit Martinique (26.8%). In St Patrick, males were significantly more likely than females to have a positive ASOT (p = 0.0084). In St George's, males were significantly more likely than females to have a positive throat culture (p = 0.0172). Thirty-four per cent of the positive cultures were type A, 10% were type C and 56% type G. The data illustrate that there is a high prevalence of beta-haemolytic streptococci in school children in certain parishes in Grenada. Public health measures should address prevention and control of beta3-haemolytic streptococcal infection in order to prevent the possible sequelae of this disease.

  19. Emphasis: Teachers Doing Research.

    ERIC Educational Resources Information Center

    Knudson, Richard L., Ed.

    1975-01-01

    The emphasis of this issue, reflecting increased demand for accountability, is the importance of teachers gathering data which substantiate pupil growth and present facts about what is going on in English classrooms, especially when teachers are trying different classroom approaches. Articles also discuss student responses to literature, student…

  20. Emphasis in Telugu.

    PubMed

    Prabhakar Babu, B A

    1977-01-01

    The phenomenon of emphasis is studied with regard to the phonetic variation of the vowel and consonant units of the word structure in Telugu, a Dravidian language spoken mainly in South India. The electro-aerometer and the mingograph are used to provide phonetic evidence. The study reveals that different means are used to emphasise words of different structures so that the phonological structure is not disturbed.

  1. 78 FR 69432 - National Institute on Aging; Cancellation of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Cancellation of Meeting Notice is hereby given of the cancellation of the National Institute on Aging Special Emphasis Panel, December 18, 2013, 2:00 p.m. to December 18, 2013, 3:15 p.m., National Institute of Aging, Gateway...

  2. Strategy for the estimation of chronological age using the aspartic acid racemization method with special reference to coefficient of correlation between D/L ratios and ages.

    PubMed

    Ohtani, Susumu; Yamamoto, Toshiharu

    2005-09-01

    The estimation of chronological age has been performed by various methods in forensic science. Among these, racemization methods, which are based on the age-dependent non-enzymatic changes of L-form amino acids to D-form mainly using aspartic acid, are one of the most reliable and accurate methods to date. Separation of enantiomers is generally performed by gas chromatography or high performance liquid chromatography. Various tissues with low metabolic rates have been applied for this purpose. In addition, single proteins purified from these target tissues are also applicable. In this brief review we describe this method in detail, noting points of caution, as well as the advantages and disadvantages of the different target tissues. In addition, special attention is given to the correlation rates obtained between chronological age and enantiomer ratios. Currently, based on accuracy of estimated age, simplicity of the method, time required, and reproducibility, tooth dentin is considered one of the best target tissues. Alternatively, analysis of osteocalcin and elastin have also provided accurate and reproducible results.

  3. Crisis Model for Older Adults: Special Considerations for an Aging Population

    ERIC Educational Resources Information Center

    Jungers, Christin M.; Slagel, Leslie

    2009-01-01

    As the U.S. population ages, counselors must begin structuring their interactions to meet the unique needs of older adults, especially in the area of crisis intervention. The purposes of this article are to draw attention to the rapidly growing, often disregarded older population and to introduce the Crisis Model for Older Adults (CM-OA), an…

  4. Training Needs in Gerontology; Hearing before the Special Committee on Aging, United States Senate, Ninety-Fourth Congress, First Session. Part 3--Washington, D.C.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    Hearing before the Senate Special Committee on Aging was held to consider the need for funds to provide professional training in the field of gerontology as authorized under the Older Americans Act. Provision for special skills training was made under title IV of the Act but no funds were included for it in the 1975 and 1976 budgets. A statement…

  5. ADHD in school-aged youth: Management and special treatment considerations in the primary care setting.

    PubMed

    Weed, Elizabeth D

    Attention-deficit/hyperactivity disorder is considered one of the most common neurodevelopmental disorders of childhood. Primary care providers are in the unique position of providing comprehensive care-routine care, well child visits, immunizations, and other healthcare needs-to a majority of children and adolescents with attention-deficit/hyperactivity disorder. As such, primary care providers are pivotal in the diagnosis, management, and treatment of this population. This article will address special treatment considerations to aid in the management of attention-deficit/hyperactivity disorder in the primary care setting, including substance use disorders and diversion, cardiac issues and stimulant medication, medication holidays and follow-up monitoring. The database of PubMed was searched using keywords that included attention-deficit/hyperactivity disorder, children, prevalence, medication holidays, safety, cardiovascular, cardiac, blood pressure, substance use, diversion, adverse drug reactions; inclusion dates were January 1, 2011 to September 30, 2015.

  6. The special status of sad infant faces: age and valence differences in adults' cortical face processing.

    PubMed

    Colasante, Tyler; Mossad, Sarah I; Dudek, Joanna; Haley, David W

    2016-12-20

    Understanding the relative and joint prioritization of age- and valence-related face characteristics in adults' cortical face processing remains elusive because these two characteristics have not been manipulated in a single study of neural face processing. We used electroencephalography to investigate adults' P1, N170, P2 and LPP responses to infant and adult faces with happy and sad facial expressions. Viewing infant vs adult faces was associated with significantly larger P1, N170, P2 and LPP responses, with hemisphere and/or participant gender moderating this effect in select cases. Sad faces were associated with significantly larger N170 responses than happy faces. Sad infant faces were associated with significantly larger N170 responses in the right hemisphere than all other combinations of face age and face valence characteristics. We discuss the relative and joint neural prioritization of infant face characteristics and negative facial affect, and their biological value as distinct caregiving and social cues.

  7. Transportation in an aging society: improving mobility and safety for older persons. Volume 1. Committee report and recommendations. Special report

    SciTech Connect

    Not Available

    1988-01-01

    In June 1986, the Transportation Research Board began a project to investigate the needs and problems of older Americans in relation to the U.S. roadway-transportation system. A committee of experts was appointed to review the design and operational features of the roadway system and to recommend steps to improve the mobility and safety of older users--drivers, passengers, pedestrians--who are an integral part of the system. The committees found that people over the age of 75 are involved in more fatal crashes than any other group except teenagers. Nevertheless they decided that 'age alone is a poor predictor of the performance of any individual.' Rather than restricting licenses at any given maximum age, the committee recommended that highway safety be improved by making adjustments to the design of highway features and that license screening tests be adapted to better identify people of all ages who have impairments that would affect driving. The committee also recommended improved specialized transportation for the frail elderly.

  8. 78 FR 20669 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Management of the Primate Aging Database Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  9. 77 FR 34394 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Healthy Aging and the Life Course. Date: June...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  10. 75 FR 39698 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Network Infrastructure for Aging Research...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  11. 77 FR 63843 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Aging and Sleep. Date: November 8, 2012. Time... on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892,...

  12. 76 FR 32977 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Aging and Economics. Date: June 24, 2011... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892 (Telephone...

  13. 77 FR 40370 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Aging and Innovation. Date: July 11, 2012... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  14. 77 FR 14026 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Reprogramming, Aging and Alzheimer's Disease... Lewis, Ph.D., Scientific Review Branch, National Institute on Aging, Gateway Building, Suite 2C212,...

  15. 75 FR 79386 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Hormone Therapy and Cognitive Aging. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  16. 75 FR 18513 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Aging Program Project Review. Date: May 5... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892...

  17. 75 FR 63497 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Genetic Determinants of Healthy Aging. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  18. 75 FR 67381 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel HIV, HAART and AGING. Date: November 23, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  19. 77 FR 11563 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Systems Biology of Aged in Yeast. Date: March... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892,...

  20. 75 FR 43995 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: July 21, 2010... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Healthy Aging; Search for Mechanisms....

  1. 77 FR 58854 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Cognitive Aging. Date: November 7, 2012 Time... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892 Contact...

  2. 78 FR 16859 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Development and Maintenance of an Aged...

  3. 76 FR 22407 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ..., Aging Research, National Institutes of Health, HHS) Dated: April 14, 2011. Jennifer S. Spaeth, Director... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Aging and Mobility. Date: May 12, 2011....

  4. Evaluation of a group intervention to assist aging parents with permanency planning for an adult offspring with special needs.

    PubMed

    Botsford, Anne L; Rule, David

    2004-07-01

    More than three-fourths of older adults with developmental disabilities and mental illness live in the community with aging parents, the majority of whom do not complete plans for the residential, financial, and legal future of their offspring. The authors used a true experimental design to evaluate the effectiveness of a six-week psychoeducational group intervention with 27 older mothers. Data collected in pre- and posttest telephone interviews were analyzed with repeated measures MANCOVA to test five hypotheses. Significant multivariate effects were found for mothers' knowledge and awareness about permanency planning, confidence and competence to plan, planning activities, and stage of planning. Findings support use of group interventions with older parents and underscore the need for professional education about planning for adults with special needs.

  5. Five years of interdisciplinary research on ageing and technology: Outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL)--an introduction to this Special Issue on Ageing and Technology.

    PubMed

    Haux, Reinhold; Hein, Andreas; Kolb, Gerald; Künemund, Harald; Eichelberg, Marco

    2014-01-01

    This Special Issue of Informatics for Health and Social Care is presenting outcomes of the Lower Saxony Research Network Design of Environments for Ageing (abbreviated as GAL), probably one of the largest inter- and multidisciplinary research projects on aging and technology. In order to investigate and provide answers on whether new information and communication technologies can contribute to keeping, or even improving quality of life, health and self-sufficiency in ageing societies through new ways of living and new forms of care, GAL had been established as a five-year research project, running from 2008 to 2013. Ambient-assisted living technologies in personal and home environments were especially important. During the five years of research in GAL, more than seventy researchers from computer science, economics, engineering, geriatrics, gerontology, informatics, medicine, nursing science and rehabilitation pedagogy intensively collaborated in finding answers.

  6. Special session on environment and energy, and repeated emphasis from early-`80s onwards, hybrid-drive targets for penetrating beams, that encompasses ultra high intensity lasers and/or particle beams

    SciTech Connect

    Mark, J.W. ||

    1994-10-05

    In this special session, we discuss {bold global} {bold climate} {bold change} concerns, as well as {bold cleanup} {bold of} {bold wastes} {bold and}/{bold or} {bold toxic} {bold materials}, their relations to energy and other technologies. We especially bring together scientists to discuss available and/or developable technologies of amelioration or cleanup, for consideration of unusual uses of {bold Lasers}, {bold Particle} {bold Beams} {bold and} {bold other} {bold plasma} Phenomena. {copyright}{ital American} {ital Institute} {ital of} {ital Physics} 1994

  7. Age-related geriatric medicine: relevance of special skills of geriatric medicine to elderly people admitted to hospital as medical emergencies.

    PubMed Central

    Kafetz, K; O'Farrell, J; Parry, A; Wijesuriya, V; McElligott, G; Rossiter, B; Lugon, M

    1995-01-01

    This study was carried out to find out how many patients aged 75 and over admitted to hospital as medical emergencies had features appropriate to care by physicians in geriatric medicine and to examine the extent of use of specialist facilities by these patients. The purpose was to examine criticisms of age-related admission policies which have focused on misplacement of patients with single diagnoses and lack of access to specialist care. An analysis was made of admission, process and discharge characteristics relevant to the special skills of geriatric medicine, multiple pathology and use of specialist services by 554 patients aged 75 and over. These were collected prospectively, consecutively admitted as medical emergencies via the accident and emergency department of a large district general hospital with an age-related (75 and over) medical admissions policy. 84 patients (15%) had single pathology and no characteristics suggesting the need for specialist geriatric care. 177 (32%) had single pathology and one or more specialized characteristics. 66 (12%) had multiple pathology alone. 227 (41%) had multiple pathology and specialized characteristics. There were 142 specialist referrals in 121 patients (22% of the whole sample). We concluded that the special skills of general physicians specializing in the medical and associated community problems of elderly people are highly relevant to patients aged 75 and over presenting as medical emergencies. There was no evidence of lack of involvement of specialists in their care. PMID:8544147

  8. Age-related geriatric medicine: relevance of special skills of geriatric medicine to elderly people admitted to hospital as medical emergencies.

    PubMed

    Kafetz, K; O'Farrell, J; Parry, A; Wijesuriya, V; McElligott, G; Rossiter, B; Lugon, M

    1995-11-01

    This study was carried out to find out how many patients aged 75 and over admitted to hospital as medical emergencies had features appropriate to care by physicians in geriatric medicine and to examine the extent of use of specialist facilities by these patients. The purpose was to examine criticisms of age-related admission policies which have focused on misplacement of patients with single diagnoses and lack of access to specialist care. An analysis was made of admission, process and discharge characteristics relevant to the special skills of geriatric medicine, multiple pathology and use of specialist services by 554 patients aged 75 and over. These were collected prospectively, consecutively admitted as medical emergencies via the accident and emergency department of a large district general hospital with an age-related (75 and over) medical admissions policy. 84 patients (15%) had single pathology and no characteristics suggesting the need for specialist geriatric care. 177 (32%) had single pathology and one or more specialized characteristics. 66 (12%) had multiple pathology alone. 227 (41%) had multiple pathology and specialized characteristics. There were 142 specialist referrals in 121 patients (22% of the whole sample). We concluded that the special skills of general physicians specializing in the medical and associated community problems of elderly people are highly relevant to patients aged 75 and over presenting as medical emergencies. There was no evidence of lack of involvement of specialists in their care.

  9. Sodium Intake of Special Populations in the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Study

    PubMed Central

    Cotugna, Nancy; Fanelli-Kuczmarksi, Marie; Clymer, Julie; Hotchkiss, Lawrence; Zonderman, Alan B.; Evans, Michele K.

    2013-01-01

    Objective The sodium intake of participants of the Healthy Aging in Neighborhoods of Diversity across the Life Span study who were in three of the special population groups identified by the Dietary Guidelines for Americans, 2010 (those with hypertension, African Americans, and those ≥51 years) was analyzed to determine if they met sodium recommendations. Methods The sample included 2152 African American and White subjects, aged 30-64 years. Major dietary sources of sodium for each group were determined from two 24-hour dietary recalls, and dietary intakes were compared with sodium recommendations. Dietary potassium was also evaluated. Results The intakes of the groups studied exceeded 1500 mg sodium while their potassium intakes were lower than the Adequate Intake of 4700 mg. The major contributors of sodium included “cold cuts, sausage, and franks,” “protein foods”, and yeast breads. Conclusions Excessive sodium intake characterized the diet of an urban, socioeconomically diverse population who are hypertensive or at risk for having hypertension. These findings have implications for health professionals and the food industry. PMID:23769900

  10. The Hallmarks of Aging

    PubMed Central

    López-Otín, Carlos; Blasco, Maria A.; Partridge, Linda; Serrano, Manuel; Kroemer, Guido

    2013-01-01

    Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects. PMID:23746838

  11. 75 FR 11188 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Nursing Home Research. Date: May 7, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. (Telephone...

  12. 77 FR 56856 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Network. Date: October 4, 2012..., Ph.D., Scientific Review Officer, National Institute On Aging, Scientific Review Branch,...

  13. 78 FR 32408 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Senile Dementia. Date: June 28, 2013. Time: 1... Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, (Telephone...

  14. 78 FR 9403 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; CALERIE Dataset. Date: March 7, 2013. Time: 1... Aging, Gateway Building, Room 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, (Telephone...

  15. 75 FR 26268 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, ARRA--Behavioral Economics C.E.R.--Clinical.... Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C218, Bethesda,...

  16. 76 FR 17929 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  17. 75 FR 3476 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Clinical Services. Date: January 29, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. (Telephone...

  18. 77 FR 5030 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Testosterone Studies. Date: February 16, 2012... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  19. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Network Facilities for Developing Areas of Investigation in the Basic Biology of Aging. Date: February 9, 2012. Time: 8:30 a.m. to 9:30 a.m. Agenda:...

  20. 75 FR 56116 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Alzheimer's Disease Genetics. Date: October 4... Officer, National Institute on Aging, Scientific Review Branch, Gateway Building 2c-212, 7201...

  1. 77 FR 53207 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Pepper Centers. Date: September 27-28, 2012... Branch, National Institute on Aging, 7201 Wisconsin Avenue, Suite 2c212, Bethesda, MD 20892,...

  2. 78 FR 4423 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Worm Intervention Study. Date: February 20... Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892,...

  3. 78 FR 51196 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Juvenile Protective Factors I. Date...: National Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD...

  4. 76 FR 42719 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, The NIA Health and Retirement Study. Date.... Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda,...

  5. 75 FR 35821 - National Institute On Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... HUMAN SERVICES National Institutes of Health National Institute On Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Member Conflict SEP, Date: June 24, 2010. Time...: Ramesh Vemuri, PhD, Chief, Scientific Review Branch, National Institute on Aging, National Institutes...

  6. 75 FR 39549 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; ARRA--MIND MRI. Date: July 26, 2010. Time: 1... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212. Bethesda, MD 20892. (Telephone...

  7. 76 FR 57064 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, AD Genetics Warehouse. Date: October 7, 2011..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  8. 77 FR 1941 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; GEMSSTAR. Date: January 27, 2012. Time: 8 a.m...., Scientific Review Officer, National Institute on Aging, Gateway Building, Rm. 2C212, 7201 Wisconsin...

  9. 75 FR 11188 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Beeson Meeting. Date: April 28-29, 2010. Time..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  10. 77 FR 24728 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Health and Well-Being Across Time. Date: May...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  11. 75 FR 8374 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, New Invertebrate Models for the Biology of Aging. Date: March 18, 2010. Time: 8:30 a.m. to 3:30 p.m. Agenda: To review and evaluate...

  12. 75 FR 57965 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Member Conflict SEP. Date: October 4, 2010... Review Branch, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue,...

  13. 78 FR 36200 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Longitudinal Study Contract. Date: June 26... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20814,...

  14. 77 FR 65005 - National Institute on Aging Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Juvenile Protective Factors. Date: December 4... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact...

  15. 76 FR 5391 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Pepper Centers. Date: February 17-18, 2011..., Scientific Review Branch, National Institute on Aging, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  16. 75 FR 25273 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Basis of Myocardial Injury in the Elderly...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  17. 77 FR 56855 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Skeletal Muscle. ] Date: October 23, 2012... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892...

  18. 77 FR 21790 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Loan Repayment 2012. Date: May 2, 2012. Time... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact Person:...

  19. 77 FR 34396 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Changing Long Term Care in America. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  20. 76 FR 28794 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Longevity Consortium. Date: June 9, 2011... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  1. 76 FR 6628 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Sex Differences in Health and Survival. Date..., Scientific Review Officer, National Institutes on Aging, National Institutes of Health, 7201 Wisconsin...

  2. 77 FR 21790 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Pathology of Alzheimer's Disease. Date: May 7... Institute on Aging, Gateway Building 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892,...

  3. 76 FR 55691 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Aminergic Function and Brain Aging II....

  4. 76 FR 575 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; ADCC Meeting. Date: February 24-25, 2011... Review Officer, Scientific Review Branch, National Institute on Aging, Gateway Building, Suite 2C212,...

  5. 76 FR 82313 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Beeson Review 2012/05. Date: February 24, 2012... Parsadanian, Ph.D., Scientific Review Officer, National Institute on Aging, Gateway Building 2c/212,...

  6. 77 FR 8889 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Member Conflict. Date: March 1, 2012. Time: 2...., Chief, Scientific Review Branch, National Institute on Aging, National Institutes of Health,...

  7. 76 FR 4927 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: January 20, 2011. Jennifer... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Beeson Review. Date: February 18, 2011....

  8. 77 FR 64525 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ..., Aging Research, National Institutes of Health, HHS) Dated: October 15, 2012. Melanie J. Gray, Program... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Tuberculosis Infection in the Elderly....

  9. 78 FR 37232 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; NIA DBSR DATASETS. Date: July 11-12,...

  10. 75 FR 32489 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... of Federal Domestic Assistance Program Nos. 93.866, Aging Research; 93.701, ARRA Related Biomedical... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; ARRA--Behavioral Economics...

  11. 78 FR 67177 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ...@nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Member Conflict. Date: December 18,...

  12. 78 FR 55265 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: September 4, 2013... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Heart Failure. Date: October 3, 2013. Time:...

  13. 76 FR 11798 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ....866, Aging Research, National Institutes of Health, HHS) Dated: February 25, 2011. Jennifer S. Spaeth... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Member Conflict. Date: March 15, 2011....

  14. 75 FR 22411 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: April 21, 2010... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Lead Drug Candidates. Date: May 14,...

  15. 78 FR 70310 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ..., ferrellrj@mail.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Exercise and AD. Date: December 23,...

  16. 78 FR 75358 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ...@mail.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Vitamin D Trials. Date: January 30,...

  17. 75 FR 32958 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ..., johnsonj9@nia.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Drug Effects on Illnesses in the...

  18. 78 FR 11212 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: February 11, 2013. Melanie J... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Data Analysis. Date: April 4, 2013. Time:...

  19. 76 FR 48873 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ....gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, AD Mutation. Date: August 30, 2011. Time: 1...

  20. 78 FR 13360 - National Institute on Aging: Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health... HUMAN SERVICES National Institutes of Health National Institute on Aging: Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Member Conflict. Date: April 1, 2013....

  1. 77 FR 74677 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    .... 93.866, Aging Research, National Institutes of Health, HHS) Dated: December 12, 2012. Melanie J. Gray... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Cell Dependent and Independent...

  2. Pharmacotherapy guidelines for the aged by family doctors for the use of family doctors: part C--Special pharmacology.

    PubMed

    Bergert, F W; Conrad, D; Ehrenthal, K; Fessler, J; Gross, J; Gundermann, K; Kluthe, B; Lang Heinrich, W; Liesenfeld, A; Loew, P G; Luther, E; Pchalek, R; Seffrin, J; Sterzing, A; Wolfring, H-J; Zimmermann, U

    2009-03-01

    The part "Special pharmacology of the aged" of this guideline contains recommendations for typical conditions in the family doctors practice: in the January issue 2009 dementia and Morbus Parkinson, in this issue osteoporosis and urinary incontinence and in the next issue rectal incontinence and obstipation. This issue of the IJCPT contains the third part of the Pharmacotherapy guidelines for the aged by family doctors for family doctors. Part 3: Osteoporosis and urinary incontinence. Osteoporosis is a systematic disease characterized by low bone mass and declining bone structure. Exercise, adequate diet, nicotine abstinence as well as reduction of alcohol consumption may counteract the progression of the disease. Osteoporosis manifests in bone fractures with minimal trauma. Attention must be given to the risk of falling, e.g., by avoiding drugs that increase the risk of falling: e.g., psychotropic agents, analgesic drugs and antiarrhythmic agents. Specific osteoporosis medication e.g. calcium, vitamin D, biphosphonates and SERM (selective estrogen receptor modulators) is evaluated by family doctors according to indication, dosage, contraindications, long-term therapy and nature of any fracture. Duration of therapy is at least 3 - max. 5 years followed by reassessment of indication. There are 3 types of urine incontinence (urge-, stress-, and overflow-incontinence). Another standardization of urinary incontinence follows dysfunctions of the pelvic floor: detrusor muscle-dependent, due to sphincter spasm, prostate gland dependent. Urge incontinence with a dysfunction of the detrusor muscle is the most common type. Mixed types are frequent. Non-drug measures (e.g. pelvic muscle training, bladder training, toilet training are first choice treatments. Drug therapy (estrogen, imipramine) are without proven effect.

  3. Effects of dry, vacuum, and special bag aging; USDA quality grade; and end-point temperature on yields and eating quality of beef Longissimus lumborum steaks.

    PubMed

    Dikeman, Michael E; Obuz, Ersel; Gök, Veli; Akkaya, Levent; Stroda, Sally

    2013-06-01

    This study evaluated the effects of three aging methods: (dry (D), wet (W), and special bag (SB)); two quality grades [USDA Choice((≥Small(50) marbling) and Select); and two cooked end-point temperatures (62.8 °C and 71.1 °C) on physico-chemical traits of instrumental tenderness, color, and sensory properties of Longissimus lumborum beef muscle. Dry-aged loins had higher (P<0.0001) weight loss than W or SB aged loins. However, D and SB aged loins had similar (P>0.05) combined losses. W aged loins had higher (P<0.01) L* values than D or SB aged loins. Warner-Bratzler shear force of steaks was not affected (P>0.05) by aging method or quality grade but increased (P<0.0001) as end-point temperature increased. Sensory panel evaluation also showed no effect (P>0.05) of aging method or quality grade on myofibrillar tenderness, juiciness, connective tissue amount, overall tenderness or off flavor intensity. Steaks cooked to 62.8 °C were juicier (P<0.05) than those cooked to 71.1 °C. Neither D nor SB aging had advantages over W aging.

  4. Diagnostic History and Treatment of School-Aged Children with Autism Spectrum Disorder and Special Health Care Needs

    MedlinePlus

    ... psychotropic medication use in children with ASD ( 10 ). Definitions Children with special health care needs (CSHCN) : The ... at the time of the Pathways interview. (See " Definitions " for question wording.) All estimates shown in this ...

  5. Nephrology in Latin America, with special emphasis on Brazil.

    PubMed

    Zatz, Roberto; Romão, J E; Noronha, I L

    2003-02-01

    Latin America constitutes a complex universe that shows extreme variation regarding socioeconomic and human development. Brazil is the largest and most populous Latin American country, and combines characteristics encountered in developed countries with problems typically associated with the poorest regions of the world. These disparities condition the profile of renal disease in Brazil, with glomerulonephritis still the leading cause of ESRD. Little is known about the epidemiology of renal disease in the Brazilian (or Latin American) native population, which is numerous in some Central and South American countries, but constitute a very small minority in Brazil. However, interesting information has been obtained from the Yanomamis, a tribe living in Northern Brazil and Southern Venezuela. Hypertension is virtually absent among these people, who ingest very little sodium, lending strong support to the concept that sodium retention, a "civilization" factor, plays a role in the pathogenesis of arterial hypertension. Despite Brazil's striking socioeconomic disparities, access to RRT is in principle accessible to all those in need of it. The dialysis units have been modernized in recent years, whereas the Government covers most expenses related to RRT. However, the prevalence of RRT in Brazil is currently approximately 320 per million population, less than one third as high as in the US, suggesting that ESRD may be underdiagnosed in the country. Much effort is still needed to limit the prevalence of renal disease and to improve the quality and the reach of RRT in Brazil and in Latin America.

  6. Morbillivirus infections, with special emphasis on morbilliviruses of carnivores.

    PubMed

    Barrett, T

    1999-09-01

    Morbilliviruses infections cause significant mortality in human beings and animals. Measles virus is responsible for up to two million childhood deaths annually in the developing world, while rinderpest and peste des petits ruminants cause severe epizootics in domestic and wild ruminants in areas of the world where they remain endemic. Canine distemper virus (CDV) is a cause of fatal disease in many species of carnivores. Distemper is controlled by vaccination in domestic dogs and farmed mink, but it may be impossible to eradicate the virus because of its global distribution and wide variety of susceptible host species, which includes both freshwater and marine seals. Research is currently under way to develop new recombinant vaccines, since the currently available live attenuated vaccines for CDV are not safe for use for all species and many valuable zoo animals need to be protected from CDV. New morbilliviruses with potentially disastrous ecological consequences for marine mammals have been discovered in the past decade; phocid distemper virus (PDV) in seals and the cetacean morbillivirus (CMV) has been found in dolphins, whales and porpoises. Reverse transcription, coupled with the polymerase chain reaction (RT/PCR) and nucleic acid sequencing, has been used to characterise the morbilliviruses and has given insights into the evolution of this virus genus.

  7. A purview of waste management evolution: Special emphasis on USA

    SciTech Connect

    Kollikkathara, Naushad Feng, Huan; Stern, Eric

    2009-02-15

    The generation of waste in urban regions over time is seen to impact the balance of anthropogenic and natural resources. Various national and international initiatives to manage urban solid waste are in place and has thus have evolved at present to form an assortment of different subcomponents involving environmental, administrative, regulatory, scientific, market, technology, and socio-economic factors, which has increasing bearing on the US due to its volume and nature of discards. This paper draws together the various aspects of municipal solid waste (MSW) management as it evolved, particularly in the American society through reviewing works and findings. In many parts of the country, waste management at present, primarily involves landfilling, incineration with and without energy recovery, recycling and composting. Legislation, nature of wastes and market trends continue to redefine management operations and its responsibilities and impacts. Complexities are added to it by the nature of urban development as well. New studies and concepts like 3Rs, cradle-to-cradle, industrial ecology, and integrated waste management are adding new dimensions for solving waste problems towards achieving sustainable resource use. Local initiatives, both public and private are in the forefront of adopting alternate waste management procedures. The assistance from various government and private bodies, supporting shifts in waste management approaches, have immense value, as according to the new paradigms, nothing goes to waste.

  8. Distributed data base systems with special emphasis toward POREL

    NASA Technical Reports Server (NTRS)

    Neuhold, E. J.

    1984-01-01

    In the last few years a number of research and advanced development projects have resulted in distributed data base management prototypes. POREL, developed at the University of Stuttgart, is a multiuser, distributed, relational system developed for wide and local area networks of minicomputers and advanced micros. The general objectives of such data base systems and the architecture of POREL are discussed. In addition a comparison of some of the the existing distributed DMBS is included to provide the reader with information about the current state of the art.

  9. Biodiesel production with special emphasis on lipase-catalyzed transesterification.

    PubMed

    Bisen, Prakash S; Sanodiya, Bhagwan S; Thakur, Gulab S; Baghel, Rakesh K; Prasad, G B K S

    2010-08-01

    The production of biodiesel by transesterification employing acid or base catalyst has been industrially accepted for its high conversion and reaction rates. Downstream processing costs and environmental problems associated with biodiesel production and byproducts recovery have led to the search for alternative production methods. Recently, enzymatic transesterification involving lipases has attracted attention for biodiesel production as it produces high purity product and enables easy separation from the byproduct, glycerol. The use of immobilized lipases and immobilized whole cells may lower the overall cost, while presenting less downstream processing problems, to biodiesel production. The present review gives an overview on biodiesel production technology and analyzes the factors/methods of enzymatic approach reported in the literature and also suggests suitable method on the basis of evidence for industrial production of biodiesel.

  10. A review of plague persistence with special emphasis on fleas.

    PubMed

    Wimsatt, Jeffrey; Biggins, Dean E

    2009-06-01

    Sylvatic plague is highly prevalent during infrequent epizootics that ravage the landscape of western North America. During these periods, plague dissemination is very efficient. Epizootics end when rodent and flea populations are decimated and vectored transmission declines. A second phase (enzootic plague) ensues when plague is difficult to detect from fleas, hosts or the environment, and presents less of a threat to public health. Recently, researchers have hypothesized that the bacterium (Yersinia pestis) responsible for plague maintains a continuous state of high virulence and thus only changes in transmission efficiency explain the shift between alternating enzootic and epizootic phases. However, if virulent transmission becomes too inefficient, strong selection might favor an alternate survival strategy. Another plausible non-exclusive hypothesis, best supported from Asian field studies, is that Y. pestis persists (locally) at foci by maintaining a more benign relationship within adapted rodents during the long expanses of time between outbreaks. From this vantage, it can revert to the epizootic (transmission efficient) form. Similarly, in the United States (US), enzootic plague persistence has been proposed to develop sequestered within New World rodent carriers. However, the absence of clear support for rodent carriers in North America has encouraged a broader search for alternative explanations. A telluric plague existence has been proposed. However, the availability of flea life stages and their hosts could critically supplement environmental plague sources, or fleas might directly represent a lowlevel plague reservoir. Here, we note a potentially pivotal role for fleas. These epizootic plague vectors should be closely studied with newer more exacting methods to determine their potential to serve as participants in or accomplices to a plague persistence reservoir.

  11. Environmental Quality and Occupational Health Special Emphasis Area Plan (SEAP)

    DTIC Science & Technology

    1989-06-01

    applications. 5 (2) Related Program: PE/Proj Title 62202F Aerospace Biotechnology Proj 6302 Operational and Environmental Toxic Hazards in Ai "orce...a material eirl" in the acquisition process. (2) Related Program: PE/Proj Title 62202F Aerospace Biotechnology Proj 6302 Operationcl and Environmental...by USAF laboratories, resulting in substantial cost and time savings. 6 (2) Related Program: PE/Proj Title 62202F Aerospace Biotechnology Proj 6302

  12. Synthetic fuels for ground transportation with special emphasis on hydrogen

    NASA Technical Reports Server (NTRS)

    Singh, J. J.

    1975-01-01

    The role of various synthetic fuels, for ground transportation in the United States, was examined for the near term (by 1985) and the longer term applications (1985-2000 and beyond 2000). Feasible options include synthetic oil, methanol, electric propulsion, and hydrogen. It is concluded that (1) the competition during the next 50 years will be for the fuels of all types, rather than among the fuels; (2) extensive domestic oil and gas exploration should be initiated concurrent with the development of several alternate fuels and related ancillaries; and (3) hydrogen, as an automotive fuel, seems to be equivalent to gasoline for optimum fuel to air mixtures. As a pollution free, high energy density fuel, hydrogen deserves consideration as the logical replacement for the hydrocarbons. Several research and development requirements, essential for the implementation of hydrogen economy for ground transportation, were identified. Extensive engineering development and testing activities should be initiated to establish hydrogen as the future automotive fuel, followed by demonstration projects and concerted efforts at public education.

  13. A review of plague persistence with special emphasis on fleas

    USGS Publications Warehouse

    Wimsatt, Jeffrey; Biggins, Dean E.

    2009-01-01

    Here, we note a potentially pivotal role for fleas. These epizootic plague vectors should be closely studied with newer more exacting methods to determine their potential to serve as participants in or accomplices to a plague persistence reservoir.

  14. Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs

    PubMed Central

    Robertson, Larry W.; Ludewig, Gabriele

    2011-01-01

    Polychlorinated biphenyls (PCBs) are industrial chemicals used in various applications requiring chemical stabilityand have now become widely dispersed. Their characteristics of persistence, low water/higher lipid solubility, contribute to their ability to bioconcentrate and bioaccumulate. Traditionally PCBs have been regulated as food contaminants and the general population is primarily exposed by that route. PCBs in foodstuffs are generally higher chlorinated, resistant to metabolic breakdown, and elicit toxic changes that are thought to be predominantly receptor/parent PCB-driven. But for certain occupational exposures, and for those persons residing or working in contaminated buildings, and in large cities, an inhalation route of exposure may predominate. Airborne PCBs are, in contrast to foodborne PCBs, lower chlorinated, more volatile, and subject to metabolic attack. In this review, we have explored (geno-) toxic manifestations of PCBs typical of those found in air. Here metabolic conversion of the parent PCB to hydroxylated and other metabolic progeny appear to play a dominant role, especially in genotoxicity. We should be cognizant of the impact of exposures to airborne PCBs for those individuals who are occupationally exposed, for persons living near contaminated sites, for those who work or go to school in contaminated buildings, and especially cognizant of the young, the socio-economically disadvantaged and medically-underserved or nutritionally-deficient populations. PMID:21686028

  15. Brazilian borreliosis with special emphasis on humans and horses.

    PubMed

    Basile, Roberta Carvalho; Yoshinari, Natalino Hajime; Mantovani, Elenice; Bonoldi, Virgínia Nazário; Macoris, Delphim da Graça; Queiroz-Neto, Antonio de

    Borreliosis caused by Borrelia burgdorferi sensu lato is a cosmopolitan zoonosis studied worldwide; it is called Lyme disease in many countries of the Northern Hemisphere and Lyme-like or Baggio-Yoshinari Syndrome in Brazil. However, despite the increasing number of suspect cases, this disease is still neglected in Brazil by the medical and veterinary communities. Brazilian Lyme-like borreliosis likely involves capybaras as reservoirs and Amblyomma and Rhipicephalus ticks as vectors. Thus, domestic animals can serve as key carriers in pathogen dissemination. This zoonosis has been little studied in horses in Brazil. The first survey was performed in the state of Rio de Janeiro, and this Brazilian Borreliosis exhibits many differences from the disease widely described in the Northern Hemisphere. The etiological agent shows different morphological and genetic characteristics, the disease has a higher recurrence rate after treatment with antibiotics, and the pathogen stimulates intense symptoms such as a broader immune response in humans. Additionally, the Brazilian zoonosis is not transmitted by the Ixodes ricinus complex. With respect to clinical manifestations, Baggio-Yoshinari Syndrome has been reported to cause neurological, cardiac, ophthalmic, muscle, and joint alterations in humans. These symptoms can possibly occur in horses. Here, we present a current panel of studies involving the disease in humans and equines, particularly in Brazil.

  16. Developments in special geometry

    NASA Astrophysics Data System (ADS)

    Mohaupt, Thomas; Vaughan, Owen

    2012-02-01

    We review the special geometry of Script N = 2 supersymmetric vector and hypermultiplets with emphasis on recent developments and applications. A new formulation of the local c-map based on the Hesse potential and special real coordinates is presented. Other recent developments include the Euclidean version of special geometry, and generalizations of special geometry to non-supersymmetric theories. As applications we disucss the proof that the local r-map and c-map preserve geodesic completeness, and the construction of four- and five-dimensional static solutions through dimensional reduction over time. The shared features of the real, complex and quaternionic version of special geometry are stressed throughout.

  17. Linking Medical Education and Training to Rural America: Obstacles and Opportunities. Workshop before the Special Committee on Aging. United States Senate, One Hundred Second Congress, First Session (July 29, 1991).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document represents proceedings of a workshop before the Senate Special Committee on Aging. The workshop focused on the severe shortage of health professionals in the rural health care system. Opening remarks by Portia Mittelman, Staff Director of the Special Committee on Aging and Jeffrey Human, Director of the Office of Rural Health Policy…

  18. 76 FR 23827 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Osteoarthritis. Date: June 8, 2011. Time: 9 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  19. 78 FR 16273 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel. Date: April 1, 2013. Time: 12:00 p.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  20. 75 FR 18511 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Loan Repayment. Date: May 3, 2010. Time: 12 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  1. 78 FR 35041 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel SWAN. Date: June 27, 2013. Time: 9:30 a.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  2. 78 FR 66373 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special Emphasis Panel, October 16, 2013, 02:00 p.m. to October 16, 2013, 05:00 p.m., National Institute on...

  3. 78 FR 66368 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special Emphasis Panel, October 17, 2013, 12:00 p.m. to October 17, 2013, 05:00 p.m., National Institute on...

  4. 78 FR 66369 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special Emphasis Panel, October 17, 2013, 12:00 p.m. to October 17, 2013, 04:00 p.m., National Institute on...

  5. 76 FR 60058 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Reproductive Hormones and the Brain II....

  6. 75 FR 9908 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Committee: National Institute on Aging Special Emphasis Panel, Health, Behavior, and the Gene-Social Environment. Date: March 22, 2010. Time: 10 a.m. to 12:30 p.m. Agenda: To review and evaluate grant... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed...

  7. 1971 White House Conference on Aging. A Report to the Delegates from the Conference Sections and Special Concerns Sessions.

    ERIC Educational Resources Information Center

    White House Conference on Aging, Washington, DC.

    The two parts of this document contain reports relating to the normal concerns as well as the special concerns of the older adult population. In Part I, the reports discuss: Education; Employment and Retirement; Physical and Mental Health; Housing; Income; Nutrition; Retirement Roles and Activities; Spiritual Well-Being; Transportation;…

  8. A Parent's Guide to Services for Children, from Birth to Three Years of Age, with Special Needs

    ERIC Educational Resources Information Center

    Tennessee Department of Education, 2008

    2008-01-01

    This booklet introduces parents to "Tennessee's Early Intervention System" (TEIS). This system is funded through the Tennessee Department of Education. Through TEIS parents can get answers about their baby's growth and development and find the special services their child may need. Parents can also use this system to determine which…

  9. Intrinsically photosensitive retinal ganglion cell function in relation to age: A pupillometric study in humans with special reference to the age-related optic properties of the lens

    PubMed Central

    2012-01-01

    Background The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC. Methods Consensual pupil responses were explored in 44 healthy subjects aged between 26 and 68 years. A pupil response was recorded to a continuous 20 s light stimulus of 660 nm (red) or 470 nm (blue) both at 300 cd/m2 intensity (14.9 and 14.8 log photons/cm2/s, respectively). Additional recordings were performed using four 470 nm stimulus intensities of 3, 30, 100 and 300 cd/m2. The baseline pupil size was measured in darkness and results were adjusted for the baseline pupil and gender. The main outcome parameters were maximal and sustained pupil contraction amplitudes and the postillumination response assessed as area under the curve (AUC) over two time-windows: early (0–10 s after light termination) and late (10–30 s after light termination). Lens transmission was measured with an ocular fluorometer. Results The sustained pupil contraction and the early poststimulus AUC correlated positively with age (p = 0.02, p = 0.0014, respectively) for the blue light stimulus condition only. The maximal pupil contraction amplitude did not correlate to age either for bright blue or red light stimulus conditions. Lens transmission decreased linearly with age (p < 0.0001). The pupil response was stable or increased with decreasing transmission, though only significantly for the early poststimulus AUC to 300 cd/m2 light (p = 0.02). Conclusions Age did not reduce, but rather enhance pupil responses mediated by ipRGC. The age related decrease of blue light transmission led

  10. Differences in physical fitness and gross motor coordination in boys aged 6-12 years specializing in one versus sampling more than one sport.

    PubMed

    Fransen, Job; Pion, Johan; Vandendriessche, Joric; Vandorpe, Barbara; Vaeyens, Roel; Lenoir, Matthieu; Philippaerts, Renaat M

    2012-01-01

    The Developmental Model of Sports Participation proposes two pathways towards expertise in sports between 6 and 12 years of age: early specialization and early diversification. This study investigated the effect of sampling various sports and of spending many or few hours in sports on fitness and gross motor coordination. Altogether, 735 boys in three age groups (6-8, 8-10, and 10-12 years) were profiled using a fitness test battery. A computerized physical activity questionnaire was used to obtain data on sports participation. In the eldest group, (M)ANCOVA showed a positive effect of sampling various sports on strength, speed, endurance, and gross motor coordination (P < 0.05). A positive effect of many hours per week spent in sports was apparent in every age group. These data suggest an acute positive effect of many hours in sports and a latent positive effect of early sampling on fitness and gross motor coordination. Multiple comparisons revealed that boys aged 10-12 years, who spent many hours in various sports, performed better on standing broad jump (P < 0.05) and gross motor coordination (P < 0.05) than boys specializing in a single sport. Therefore, our results highlight the importance of spending many hours in sports and sampling various sports in the development of fitness and gross motor coordination.

  11. Aging

    PubMed Central

    Park, Dong Choon

    2013-01-01

    Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction. PMID:24653904

  12. 62 FR 999 - Sepcial Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-01-07

    ... Sepcial Emphasis Panel in Information, Robotics and Intelligent Systems; Notice of Meeting In accordance... announces the following meeting. Name: Special Emphasis Panel in Information, Robotics and Intelligent (1200... NSF for financial support. Agenda: To review and evaluate Robotics and Machine and...

  13. MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity.

    PubMed

    Toren, Dmitri; Barzilay, Thomer; Tacutu, Robi; Lehmann, Gilad; Muradian, Khachik K; Fraifeld, Vadim E

    2016-01-04

    Mitochondria are the only organelles in the animal cells that have their own genome. Due to a key role in energy production, generation of damaging factors (ROS, heat), and apoptosis, mitochondria and mtDNA in particular have long been considered one of the major players in the mechanisms of aging, longevity and age-related diseases. The rapidly increasing number of species with fully sequenced mtDNA, together with accumulated data on longevity records, provides a new fascinating basis for comparative analysis of the links between mtDNA features and animal longevity. To facilitate such analyses and to support the scientific community in carrying these out, we developed the MitoAge database containing calculated mtDNA compositional features of the entire mitochondrial genome, mtDNA coding (tRNA, rRNA, protein-coding genes) and non-coding (D-loop) regions, and codon usage/amino acids frequency for each protein-coding gene. MitoAge includes 922 species with fully sequenced mtDNA and maximum lifespan records. The database is available through the MitoAge website (www.mitoage.org or www.mitoage.info), which provides the necessary tools for searching, browsing, comparing and downloading the data sets of interest for selected taxonomic groups across the Kingdom Animalia. The MitoAge website assists in statistical analysis of different features of the mtDNA and their correlative links to longevity.

  14. Sources of tooth wear variation early in life among known-aged wild ring-tailed lemurs (Lemur catta) at the Bezà Mahafaly Special Reserve, Madagascar.

    PubMed

    Cuozzo, Frank P; Head, Brian R; Sauther, Michelle L; Ungar, Peter S; O'Mara, M Teague

    2014-11-01

    Ring-tailed lemurs (Lemur catta) at the Bezà Mahafaly Special Reserve (BMSR), Madagascar display a high frequency of individuals with notable and sometimes extreme tooth wear. Adult lemurs display a range of tooth wear even among individuals of the same age, but we do not know at what age this variation first appears. This study's goal was to determine whether wear variation occurs in younger wild lemurs. Based on the decade-long study of ring-tailed lemur feeding and dental ecology at BMSR, we hypothesized that younger, natal lemurs (under 5 years of age), would display variation in their degree of tooth wear that would correspond to microhabitat differences, given differences in food availability in different troops' home ranges. We also hypothesized that wear would differ between sexes at this young age, given differences in feeding between males and females in this population. Hypotheses were tested using dental topographic analyses using dental impressions collected from known-aged lemurs across 10 years at BMSR. Results illustrate significant differences in wear-related tooth topography (i.e., relief and slope, presented here as "occlusal lift") for microhabitat, sex and troop affiliation among lemurs under 5 years of age in this population. Although, all lemurs in this population consume mechanically challenging tamarind fruit, those in more disturbed habitats eat additional introduced foods, some of which are also mechanically challenging. Thus, dietary variation is the likely cause of variation in tooth wear. The wear variation we show at a young age suggests caution when assigning age based on tooth wear in living and fossil primates. These wear-related tooth shape changes early in life, which reflects sex, habitat variation and levels of anthropogenic disturbance, may potentially impact reproductive fitness later in life.

  15. State Pilots Sweeping Changes in Special Ed

    ERIC Educational Resources Information Center

    Adkins, Gary

    2007-01-01

    The Illinois State Board of Education launched a special education pilot project using a concept called Response to Intervention (RtI) that some experts believe could lead to a sea change in the way special education is provided. RtI places greater emphasis on early intervention and a reduced emphasis on psychological testing and other traditional…

  16. Special Issue: Intellectual Property in the Information Age: Knowledge as Commodity and its Legal Implications for Higher Education

    ERIC Educational Resources Information Center

    Sun, Jeffrey C., Ed.; Baez, Benjamin, Ed.

    2009-01-01

    This monograph examines in great detail two kinds of intellectual property: copyrights and patents. Though the authors recognize the significance of trademarks and trade secrets, they focus primarily on copyrights and patents in this monograph because they represent the most significant issues in higher education in the information age.…

  17. Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects.

    PubMed

    Hayashi, Tomonori; Morishita, Yukari; Khattree, Ravindra; Misumi, Munechika; Sasaki, Keiko; Hayashi, Ikue; Yoshida, Kengo; Kajimura, Junko; Kyoizumi, Seishi; Imai, Kazue; Kusunoki, Yoichiro; Nakachi, Kei

    2012-11-01

    Past exposure to atomic bomb (A-bomb) radiation has exerted various long-lasting deleterious effects on the health of survivors. Some of these effects are seen even after >60 yr. In this study, we evaluated the subclinical inflammatory status of 442 A-bomb survivors, in terms of 8 inflammation-related cytokines or markers, comprised of plasma levels of reactive oxygen species (ROS), interleukin (IL)-6, tumor necrosis factor α (TNF-α), C-reactive protein (CRP), IL-4, IL-10, and immunoglobulins, and erythrocyte sedimentation rate (ESR). The effects of past radiation exposure and natural aging on these markers were individually assessed and compared. Next, to assess the biologically significant relationship between inflammation and radiation exposure or aging, which was masked by the interrelationship of those cytokines/markers, we used multivariate statistical analyses and evaluated the systemic markers of inflammation as scores being calculated by linear combinations of selected cytokines and markers. Our results indicate that a linear combination of ROS, IL-6, CRP, and ESR generated a score that was the most indicative of inflammation and revealed clear dependences on radiation dose and aging that were found to be statistically significant. The results suggest that collectively, radiation exposure, in conjunction with natural aging, may enhance the persistent inflammatory status of A-bomb survivors.

  18. Retirement, Work, and Lifelong Learning; Hearing Before the Special Committee on Aging, Ninety-Fifth Congress, Second Session. Part 3.

    ERIC Educational Resources Information Center

    Arizona State Dept. of Economic Planning and Development, Phoenix.

    The transcripts of the testimony given before the Senate Committee by the Chairman of the Civil Service Commission, Alan Campbell, and Stanley Babson, management consultant and former vice president of finance for Technicon Corporation, are presented. Statements address the following issues of concern: age discrimination, management of job skills,…

  19. Model Development and Trial of Early Detection Manual for the Special Needs Children at Early Age Education Level

    ERIC Educational Resources Information Center

    Anwar, Zainul; Ingarianti, Tri Muji; Suryaningrum, Cahyaning

    2016-01-01

    This research was aimed to produce the manual for early detection for ABK at the level of early age education (PAUD = "Pendidikan Anak Usia Dini"). Research was "action research" with stages as proposed by Buunk and Van Vugt. Metodology of research these stages were called as PATH ("Problem-Analysis-Test…

  20. Children born small for gestational age are not at special risk for preschool emotion and behaviour problems.

    PubMed

    Cornforth, Christine M; Thompson, John M D; Robinson, Elizabeth; Waldie, Karen E; Pryor, Jan E; Clark, Philippa; Becroft, David M O; Sonuga-Barke, Edmund J S; Mitchell, Edwin A

    2012-07-01

    Despite the wealth of literature examining long term outcomes of preterm low birthweight children, few studies have directly assessed the developmental impact of being born full term but small for gestational age (SGA). We aim to determine whether (i) being SGA increases preschool behavioural problems and (ii) other risk factors operate differently in SGA and appropriate for gestational age (AGA) controls. 550 New Zealand European mothers and their 3.5 year old children participated in this study. All children were born at full term (>37 weeks' gestation) and approximately half were SGA (≤sex specific 10th percentile for gestation) the remainder were AGA controls. Extensive data were collected at the child's birth, 1 year and 3.5 years. Behavioural problems were measured when children were 3.5 years, using the Strengths and Difficulties Questionnaire (SDQ). Multiple regression analyses were used to examine the associations between risk factors and behavioural problems; statistical weighting was used for analyses of the total study group. There was no significant difference in behavioural problems between SGA and AGA groups. In the total sample the significant predictors of behavioural problems included: mothers' school leaving age; smoking during pregnancy; maternal alcohol use during pregnancy; and absence of the father. Predictors of behavioural problems were found to be the same for SGA and AGA groups. These results do not support the view that SGA is a risk for behavioural preschool difficulties or that SGA children are sensitised to risks known to be associated with such difficulties in the preschool years.

  1. [White House Conference on Aging, 1981. Creating an Age Integrated Society: Implications for the Media. Report and Executive Summary of the Technical Committee.

    ERIC Educational Resources Information Center

    Tanenbaum, Marc H.; And Others

    The relationship of older Americans to the new media culture of society is the focus of this Technical Committee Report. The work of two committee-appointed subcommittees on stereotypes and new media technology are explained with a special emphasis on the influence of television. Age stereotyping is examined in prime time television, daytime…

  2. Bio-energetic profile in 144 boys aged from 6 to 15 years with special reference to sexual maturation.

    PubMed

    Falgairette, G; Bedu, M; Fellmann, N; Van-Praagh, E; Coudert, J

    1991-01-01

    The effects of growth and pubertal development on bio-energetic characteristics were studied in boys aged 6-15 years (n = 144; transverse study). Maximal oxygen consumption (VO2max, direct method), mechanical power at VO2max (PVO2max), maximal anaerobic power (Pmax; force-velocity test), mean power in 30-s sprint (P30s; Wingate test) were evaluated and the ratios between Pmax, P30s and PVO2max were calculated. Sexual maturation was determined using salivary testosterone as an objective indicator. Normalized for body mass VO2max remained constant from 6 to 15 years (49 ml.min-1.kg-1, SD 6), whilst Pmax and P30s increased from 6-8 to 14-15 years, from 6.2 W.kg-1, SD 1.1 to 10.8 W.kg-1, SD 1.4 and from 4.7 W.kg-1, SD 1.0 to 7.6 W.kg-1, SD 1.0, respectively, (P less than 0.001). The ratio Pmax:PVO2max was 1.7 SD 3.0 at 6-8 years and reached 2.8 SD 0.5 at 14-15 years and the ratio P30s:PVO2max changed similarly from 1.3 SD 0.3 to 1.9 SD 0.3. In contrast, the ratio Pmax:P30s remained unchanged (1.4 SD 0.2). Significant relationships (P less than 0.001) were observed between Pmax (W.kg-1), P30s (W.kg-1), blood lactate concentrations after the Wingate test, and age, height, mass and salivary testosterone concentration. This indicates that growth and maturation have together an important role in the development of anaerobic metabolism.

  3. Blacks in Alabama; A Study of Selected Characteristics: Population, Place of Residence, Sex, Age.

    ERIC Educational Resources Information Center

    Jones, Alice; Diener, Thomas

    Using 1970 Federal Census data, this paper analyzes selected characteristics of the black population in Alabama, focusing on the following categories: (1) blacks in Alabama counties; (2) urban and rural blacks; and (3) blacks in Alabama by sex and age. Special emphasis is placed on producing and interpreting data by which postsecondary education…

  4. 76 FR 1625 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease 2011... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  5. 78 FR 66015 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  6. 78 FR 63999 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Disease Sequencing Project. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  7. 78 FR 62639 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Disease Research... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  8. 77 FR 26770 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Committee: National Institute on Aging Special Emphasis Panel; Presenilin and Alzheimer's Disease. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  9. 76 FR 19105 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Committee: National Institute on Aging Special Emphasis Panel; Pathobiology of Alzheimer's Disease. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  10. 78 FR 30932 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Special Emphasis Panel; Heart Failure and Obesity. Date: July 10, 2013. Time: 1:00 p.m. to 5:00...

  11. The effects of age and past and present behavioral specialization on behavior of workers of the red wood ant Formica polyctena Först. during nestmate reunion tests.

    PubMed

    Korczyńska, Julita; Szczuka, Anna; Symonowicz, Beata; Wnuk, Andrzej; Anna, Gonzalez Szwacka; Mazurkiewicz, Paweł Jarosław; Studnicki, Marcin; Godzińska, Ewa Joanna

    2014-09-01

    Social insect workers usually participate first in intranidal tasks and then switch to extranidal ones. However, foragers may switch again to intranidal brood care. This process is called the behavioral reversion. We applied dyadic nestmate reunion tests to explore behavioral differences between five groups of workers of the red wood ant Formica polyctena: callows (newly eclosed workers), nurses, reverted nurses (foragers that switched back to intranidal brood care in response to exposure to brood in absence of nurses), and two groups of foragers. Inter-group differences between the tested ants were related both to age and past and present behavioral specialization. Callows were the least active and their behavior was characterized by the lowest tempo. Nurses usually behaved in a way intermediate in respect to behavior of callows and the ants that had already passed the transition to extranidal tasks. The behavior of reverted nurses showed both similarities and differences with respect to behavior of foragers. Some traits of behavior of reverted nurses were similar as in the case of nurses, or intermediate in respect to both nurses and foragers. Behavioral reversion of workers of F. polyctena has thus other behavioral correlates besides the reappearance of intranidal brood care.

  12. Special Education through Neighbourhood Centers in Algeria.

    ERIC Educational Resources Information Center

    Boucebci, Mahfoud

    1981-01-01

    The article provides a survey of special education needs in Algeria with emphasis on the role of neighborhood centers which involve parents in the education of mentally handicapped children. Journal availability: see EC 133 861. (DB)

  13. Software Publication Considerations and Special Education.

    ERIC Educational Resources Information Center

    Fuchs, Victor E.

    1982-01-01

    Market factors surrounding computer software in special education are examined, including proliferation of computers in schools, widespread marketing and distribution patterns for software, consumer demands for software, quality, timelessness, emphasis on basic skills, and an understanding of future capabilities. (CL)

  14. Special Days, Special Ways.

    ERIC Educational Resources Information Center

    Clarke, Jacqueline

    2001-01-01

    Presents unique ways to create special rituals that recognize individual students' achievements and milestones. Ideas include throwing a send-off party for a student who is moving; holding monthly birthday luncheons; choosing an ambassador to accompany new students around school; and making a lost tooth container that students can use to safely…

  15. Older Americans Act Amendments of 1987: A Summary of Provisions. Public Law 100-175. An Information Paper Prepared for Use by the Special Committee on Aging. United States Senate, 100th Congress, 1st Session.

    ERIC Educational Resources Information Center

    O'Shaughnessy, Carol

    The Older American Act Amendments of 1987 (Public Law 100-175) contain no major overhaul of the Act, but new provisions do significantly expand certain service components of the state and area agency on aging program under title III to address the special needs of certain populations, including the frail elderly living at home, residents of…

  16. Proposals To Eliminate Legal Barriers Affecting Elderly Mexican-Americans; A Working Paper, Prepared for the Special Committee on Aging, United States Senate, Ninety-Second Congress, Second Session.

    ERIC Educational Resources Information Center

    Reynoso, Cruz; Coppelman, Peter D.

    This report to the Special Committee on Aging of the U.S. Senate found that for no single category of the poor is there as great a gap between availability and accessibility of services as for elderly Mexican-Americans. The report proposes that as a bare minimum and meager beginning, Congress remove the unjustifiable legal barriers to obtaining…

  17. Our Greatest Generation: Continuing a Lifetime of Service. Hearing before the Special Committee on Aging. United States Senate, One Hundred Seventh Congress, First Session (Indianapolis, Indiana, August 9, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This Congressional report contains the remarks made at a special meeting of the United States Committee on Aging to celebrate senior citizen's service to their community and examine policies regarding federally funded senior service programs. The following are among the programs, agencies, and organizations represented: Senior Companion Program;…

  18. The Biology of Aging.

    ERIC Educational Resources Information Center

    Sprott, Richard L.; And Others

    1992-01-01

    Thirteen articles in this special issue discuss aging theories, biomarkers of aging, aging research, disease, cancer biology, Alzheimer's disease, stress, oxidation of proteins, gene therapy, service delivery, biogerontology, and ethics and aging research. (SK)

  19. The Library and New Research Emphasis: Political and Financial Problems with Building a Research Base.

    ERIC Educational Resources Information Center

    Buschman, John

    This paper explores issues related to the degree to which weight and emphasis are given in higher education hiring and promotion practices to research versus teaching and service. In particular it examines the special problems posed by research demands in traditionally non-research universities. Noting that one of the most significant…

  20. Syntactic Devices of Emphasis in Contemporary French.

    ERIC Educational Resources Information Center

    Hollerbach, Wolf

    A device of emphasis in French syntax is defined as a construction of syntactic paraphrase whose function is to make certain parts of a sentence stand out for purposes of contrast, clarification, differentiation, or because a given element is considered important. These devices exist in French because of the lack of a phonemic stress system, and…

  1. Emphasis upon Anthropo-Geography in Schools.

    ERIC Educational Resources Information Center

    Semple, Ellen Churchill

    1990-01-01

    Reprints a 1904 article from the "Journal of Geography" exploring geography's teaching focus. Argued for unchanged emphasis on the land and its people but advocated a deeper geographical interpretation of history. Contended that teaching should pay attention to scientific interpretation, and that children should discover a self-constructed…

  2. Acoustic Emphasis in Four Year Olds

    ERIC Educational Resources Information Center

    Wonnacott, Elizabeth; Watson, Duane G.

    2008-01-01

    Acoustic emphasis may convey a range of subtle discourse distinctions, yet little is known about how this complex ability develops in children. This paper presents a first investigation of the factors which influence the production of acoustic prominence in young children's spontaneous speech. In a production experiment, SVO sentences were…

  3. Project International Emphasis Interim Report, July 1991.

    ERIC Educational Resources Information Center

    Blois, Beverly, Ed.; Williams, Barbara

    Project International Emphasis (PIE), a curriculum development effort involving all 24 colleges in the Virginia Community College System (VCCS), focuses on the infusion of globally oriented components across the academic curriculum and in related career development programs. Activities undertaken during the project's first year included an annual…

  4. Aging of the human ovary and testis.

    PubMed

    Perheentupa, Antti; Huhtaniemi, Ilpo

    2009-02-05

    Aging is associated with structural and functional alterations in all organs of the human body. The aging of gonads represents in this respect a special case, because these organs are not functional for the whole lifespan of an individual and their normal function is not indispensable for functions of the rest of the body. Ovarian function lasts for the reproductive life of a woman, i.e., from menarche until menopause. The testicular endocrine function, in contrast, begins already in utero, is interrupted between neonatal life and puberty, and continues thereafter along with spermatogenesis, with only slight decline, until old age. The aging processes of the ovary and testis are therefore very different. We describe in this review the structural and functional alterations in the human ovary and testis upon aging. Special emphasis will be given to clinically significant alterations, which in women concern the causes and consequences of the individual variability of fertility during the latter part of the reproductive age. The clinically important aspect of testicular aging entails the decline of androgen production in aging men.

  5. Dying with Dignity: Difficult Times, Difficult Choices. A Report Presented by the Chairman of the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This report from the Select Committee on Aging examines financial, medical, and social issues surrounding terminally ill patients with special emphasis on the elderly terminally ill. The first section discusses topics related to the medical treatment of the terminally ill. Two basic issues are important: the right to have medical treatment and the…

  6. Mobile Applications for Diabetics: A Systematic Review and Expert-Based Usability Evaluation Considering the Special Requirements of Diabetes Patients Age 50 Years or Older

    PubMed Central

    Quade, Mandy; Kirch, Wilhelm

    2014-01-01

    Background A multitude of mhealth (mobile health) apps have been developed in recent years to support effective self-management of patients with diabetes mellitus type 1 or 2. Objective We carried out a systematic review of all currently available diabetes apps for the operating systems iOS and Android. We considered the number of newly released diabetes apps, range of functions, target user groups, languages, acquisition costs, user ratings, available interfaces, and the connection between acquisition costs and user ratings. Additionally, we examined whether the available applications serve the special needs of diabetes patients aged 50 or older by performing an expert-based usability evaluation. Methods We identified relevant keywords, comparative categories, and their specifications. Subsequently, we performed the app review based on the information given in the Google Play Store, the Apple App Store, and the apps themselves. In addition, we carried out an expert-based usability evaluation based on a representative 10% sample of diabetes apps. Results In total, we analyzed 656 apps finding that 355 (54.1%) offered just one function and 348 (53.0%) provided a documentation function. The dominating app language was English (85.4%, 560/656), patients represented the main user group (96.0%, 630/656), and the analysis of the costs revealed a trend toward free apps (53.7%, 352/656). The median price of paid apps was €1.90. The average user rating was 3.6 stars (maximum 5). Our analyses indicated no clear differences in the user rating between free and paid apps. Only 30 (4.6%) of the 656 available diabetes apps offered an interface to a measurement device. We evaluated 66 apps within the usability evaluation. On average, apps were rated best regarding the criterion “comprehensibility” (4.0 out of 5.0), while showing a lack of “fault tolerance” (2.8 out of 5.0). Of the 66 apps, 48 (72.7%) offered the ability to read the screen content aloud. The number of

  7. Specialization: A Detriment to Problem Conception

    ERIC Educational Resources Information Center

    Siller, Thomas J.; Johnson, Gearold R.

    2010-01-01

    Specialization is an agent of separation, both between competing specialists and between technology and society. Specialization is not an agent of integration. In the problem conception phase of the engineering design process, the emphasis must be on formulating and developing the questions that will frame the ultimate design solution. Using…

  8. Leadership in Early Childhood Special Education

    ERIC Educational Resources Information Center

    Arora, Samita Berry

    2013-01-01

    With the demands of high quality early childhood special education programs within public school settings, there is a need to place emphasis on research and training regarding early childhood leaders and managers in this complex and diverse field. The focus of this research is to examine what early childhood special education (ECSE) leadership…

  9. Rotorcraft flight research with emphasis on rotor systems

    NASA Technical Reports Server (NTRS)

    Snyder, William J.

    1988-01-01

    Over fifty years of contributions by NASA and the Army through rotor systems flight research were examined with an emphasis on the last 25 years. During this time, the helicopter has gone from an abnormality that did a few useful things to a vehicle that is a necessity to life in this country and a major part of all military forces in the world. Major data acquisition programs like the H-34 and White Cobra have been undertaken that have increased the understanding of the aerodynamic behavior of the rotor system. Specialized programs like the Ogee tip on the UH-1 and the flight tests of the hingeless rotor helicopters, the XH-13 and XH-51N, contributed greatly to the understanding of these technologies. The extensive airfoil test program also undertaken on the White Cobra provided valuable data on advanced airfoil configurations.

  10. Foamy virus assembly with emphasis on pol encapsidation.

    PubMed

    Lee, Eun-Gyung; Stenbak, Carolyn R; Linial, Maxine L

    2013-03-20

    Foamy viruses (FVs) differ from all other genera of retroviruses (orthoretroviruses) in many aspects of viral replication. In this review, we discuss FV assembly, with special emphasis on Pol incorporation. FV assembly takes place intracellularly, near the pericentriolar region, at a site similar to that used by betaretroviruses. The regions of Gag, Pol and genomic RNA required for viral assembly are described. In contrast to orthoretroviral Pol, which is synthesized as a Gag-Pol fusion protein and packaged through Gag-Gag interactions, FV Pol is synthesized from a spliced mRNA lacking all Gag sequences. Thus, encapsidation of FV Pol requires a different mechanism. We detail how WT Pol lacking Gag sequences is incorporated into virus particles. In addition, a mutant in which Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein is discussed. We also discuss temporal regulation of the protease, reverse transcriptase and integrase activities of WT FV Pol.

  11. Foamy Virus Assembly with Emphasis on Pol Encapsidation

    PubMed Central

    Lee, Eun-Gyung; Stenbak, Carolyn R.; Linial, Maxine L.

    2013-01-01

    Foamy viruses (FVs) differ from all other genera of retroviruses (orthoretroviruses) in many aspects of viral replication. In this review, we discuss FV assembly, with special emphasis on Pol incorporation. FV assembly takes place intracellularly, near the pericentriolar region, at a site similar to that used by betaretroviruses. The regions of Gag, Pol and genomic RNA required for viral assembly are described. In contrast to orthoretroviral Pol, which is synthesized as a Gag-Pol fusion protein and packaged through Gag-Gag interactions, FV Pol is synthesized from a spliced mRNA lacking all Gag sequences. Thus, encapsidation of FV Pol requires a different mechanism. We detail how WT Pol lacking Gag sequences is incorporated into virus particles. In addition, a mutant in which Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein is discussed. We also discuss temporal regulation of the protease, reverse transcriptase and integrase activities of WT FV Pol. PMID:23518575

  12. Medicine and Aging: An Assessment of Opportunities and Neglect. Hearing Before the Special Committee on Aging, United States Senate, Ninety-fourth Congress, Second Session, New York, N.Y.

    ERIC Educational Resources Information Center

    1976

    This booklet presents a complete transcript of the hearings on medicine and aging of the Senate Committee on Aging. Testimony from a number of experts in gerontology is presented. A wide range of topics is dealt with, including social attitudes toward aging, current medical training and practices, and the need for research about the aging process.…

  13. Software Acquisition in the Age of Cyber Warfare

    DTIC Science & Technology

    2011-05-01

    s c h o o l o f S Y S T E M S a n d L O G I S T I C S education service research Software Acquisition in the Age of Cyber Warfare Maj...DATE MAY 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Software Acquisition in the Age of Cyber Warfare 5a...AFIT Cyber 200/300 Courses Cyber Warfare IDE Program 34 Special Emphasis On… Enterprise Integration (Active Directory, PKI) Security

  14. Nutrition Management of School Age Children with Special Needs: A Resource Manual for School Personnel, Families, and Health Professionals. Second Edition.

    ERIC Educational Resources Information Center

    Horsley, Janet W.; Allen, Elizabeth R.; Daniel, Patricia White

    This guide is intended to help school personnel facilitate the management of special diets and nutrition education in the school curriculum in accordance with requirements of the National School Lunch Act, the Child Nutrition Act, the Rehabilitation Act of 1973 (Section 504), and the Americans with Disabilities Act of 1990. After the introduction,…

  15. Family Experiences with Accessing Information, Social and Resource Supports as Participants in Services for Their Special Needs Child over Three Years of Age

    ERIC Educational Resources Information Center

    Busillo-Aguayo, Joannie

    2010-01-01

    Families of children with special needs often experience substantial stress and an increased need for informational, social, or resource support throughout their child's growth and development. However, supports for families of children older than three often report a severe shortage of supports and difficulty accessing and utilizing them. Using…

  16. Identifying the "Subnormal" Child in an Age of Expansion of Special Education and Child Science in the Netherlands (c.1945-1965)

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2015-01-01

    Between c.1945 and 1965 across the West special education has grown and differentiated substantially. In the Netherlands this expansion ran parallel to the academic recognition and rapid development of the study of learning disabilities. How are these two processes related? This article argues that in this country child science and special…

  17. Aging and social expenditures in Italy: some issues associated with population projections.

    PubMed

    Terra Abrami, V

    1990-01-01

    "After describing the main results of the recent Italian population projections, and some possible consequences...aging may have on social expenditures, this paper focuses on attempts to improve the accuracy of development assumptions, with special regard to natural components. Emphasis is placed on the importance of applying specific methodological tools to define self-explanatory assumptions for fertility and mortality and to produce projections which could be considered, with reasonable limitations, as real forecasts."

  18. Special Education Programs & Services. [Bureau of Indian Affairs Guidelines].

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Albuquerque, NM.

    The Bureau of Indian Affairs (BIA) Guidelines for Special Education is a publication for use by educational personnel involved in special education. Emphasis is placed on the importance of preparing the exceptional child for the most useful future possible. Special education is seen as affording the exceptional child the opportunity to develop…

  19. Virtues and Well-Being of Korean Special Education Teachers

    ERIC Educational Resources Information Center

    Kim, So-Young; Lim, Young-Jin

    2016-01-01

    Although much emphasis has been paid to stress and burnout among special education teachers, little attention has been paid to their well-being. This study aimed to examine relations between virtues and well-being among Korean special education teachers. Virtues and well-being of 115 Korean special education teachers were assessed using the…

  20. The Relationship between Nutrition, Aging, and Health: A Personal and Social Challenge. Hearing before the Special Committee on Aging. United States Senate, Ninety-Ninth Congress, First Session (Albuquerque, New Mexico).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document presents witness testimonies and prepared statements from a Senate hearing called to examine the relationship between nutrition, aging, and health. An opening statement by Senator Jeff Bingaman is included. Jeffrey Blumberg, the acting associate director of the Human Nutrition Research Center on Aging, Tufts University, provides an…

  1. Thanatology Research from Quebec: A Different Emphasis.

    ERIC Educational Resources Information Center

    Mishara, Brian L.

    1993-01-01

    Notes that contributors to special journal issue have attempted to incorporate best aspects of European critical thinking within interdisciplinary and contextual approach, showing clear awareness of sociopolitical forces that affect one's relationship with mortality. Illustrates points by discussing Kurosawa film, "Ikuru," which recounts…

  2. Special Needs.

    ERIC Educational Resources Information Center

    Braswell, Ray, Ed.

    This document contains the following papers on special needs instruction and technology: (1) "Hawaii Special Education Teacher Induction" (Kalena Oliva and Quinn Avery); (2) "The Impact of Group v Individual Use of Hypermedia-Based Instruction" (Lewis R. Johnson, Louis P. Semrau, and Gail E. Fitzgerald); (3) "Assistive…

  3. Sport Specialization, Part I

    PubMed Central

    Myer, Gregory D.; Jayanthi, Neeru; Difiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

    2015-01-01

    Context: There is increased growth in sports participation across the globe. Sports specialization patterns, which include year-round training, participation on multiple teams of the same sport, and focused participation in a single sport at a young age, are at high levels. The need for this type of early specialized training in young athletes is currently under debate. Evidence Acquisition: Nonsystematic review. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Sports specialization is defined as year-round training (greater than 8 months per year), choosing a single main sport, and/or quitting all other sports to focus on 1 sport. Specialized training in young athletes has risks of injury and burnout, while the degree of specialization is positively correlated with increased serious overuse injury risk. Risk factors for injury in young athletes who specialize in a single sport include year-round single-sport training, participation in more competition, decreased age-appropriate play, and involvement in individual sports that require the early development of technical skills. Adults involved in instruction of youth sports may also put young athletes at risk for injury by encouraging increased intensity in organized practices and competition rather than self-directed unstructured free play. Strength-of-Recommendation Taxonomy (SORT): C. PMID:26502420

  4. A Study of Words Relating to Youth and Old Age in the Plays of Euripides and Its Special Implications for Euripides'"Suppliant Women."

    ERIC Educational Resources Information Center

    Thury, Eva M.

    1988-01-01

    This study focuses on imagery of youth and old age in the plays of Euripides, especially the "Suppliant Women," considering frequently used words in each play according to formula developed by Pierre Guiraud. Identifies a motif, the rejuvenation theme, in several of Euripides' plays. Shows how the word "neos" (new, young) helps…

  5. The Spectator Role: Theoretical and Developmental Studies of Ideas about and Responses to Literature, with Special Reference to Four Age Levels.

    ERIC Educational Resources Information Center

    Applebee, Arthur Noble

    Theoretical aspects of the spectator role in James Britton's (1970) model of language use are explored within a perspective based primarily on the work of George Kelly, Susanne Langer, Jean Piaget, Michael Polanyi, and Denys Harding. This view is amplified in a series of empirical studies based on stories told by children between the ages of two…

  6. [A histopathological study on aging process of the acetabulum with special reference to the pathogenesis of the acetabular cyst (author's transl)].

    PubMed

    Itoigawa, Y; Azuma, H; Kako, K

    1980-03-01

    This is to report the aging process of the acetabula studied as an aid to the investigation of the pathogenesis and progression of osteoarthritis of the acetabulum. The material consisted of 45 acetabula obtained from 45 fresh cadavers. Regarding the morphological changes of the labrum-cartilage junction of middle and old age groups, marked degenerative changes such as tear, detachment, fissuring and scar formation were observed in many cases at the loaded part of the acetabulum. Among these, a loose connective tissue had invaded into the subchondral space through a fissure in one case, and infusion of the joint fluid into a fissure was observed in another. All of the 3 acetabular cysts were from the middle and old age groups and at the weight-bearing portions of the acetabula. All cysts were found to have communication with the joint cavities through the fissures. The trabeculae surrounding the cysts showed slight destructive changes apparently due to compression by the cysts. The above findings would suggest that the cyst formation as an aging process at the weight-bearing portions is probably due to infusion of the joint fluid into the subchondral space through the fissure at the labrum-cartilage junction or through the fissure at the junction resulting from subchondral plate fracture, although some additional causative factors might also play a role in the process.

  7. Demographic Aspects of Aging and the Older Population in the United States. Current Population Reports, Special Studies, Series P-23, No. 59.

    ERIC Educational Resources Information Center

    Siegel, Jacob S.; And Others

    This report presents a statistical portrait of the demographic aspects of aging and the older population in the Unites States. Most of the estimates are based on data from decennial censuses, the program of nonsurvey population estimates and projections carried out by the U.S. Bureau of the Census, the Current Population Survey, and other census…

  8. Online Learning. Special Report.

    ERIC Educational Resources Information Center

    Training, 1998

    1998-01-01

    Special section includes "World Wide Weeds" (Ann M. Bauer), about trainers as webmasters; "Get the Picture?" (Frank Jossi)--the role of digital video in computer-based training; and "The Reluctant Executive" (Anne K. Fredrickson), how to get administrators into the information age. (JOW)

  9. Genome instability, cancer and aging

    PubMed Central

    Maslov, Alexander Y.; Vijg, Jan

    2015-01-01

    DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell death may occur or, alternatively, temporary or permanent cell cycle arrest. This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. However, erroneous DNA repair and incomplete restoration of chromatin after damage is resolved, produce mutations and epimutations, respectively, both of which have been shown to accumulate with age. An increased burden of mutations and/or epimutations in aged tissues increases cancer risk and adversely affects gene transcriptional regulation, leading to progressive decline in organ function. Cellular degeneration and uncontrolled cell proliferation are both major hallmarks of aging. Despite the fact that one seems to exclude the other, they both may be driven by a common mechanism. Here, we review age related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells. PMID:19344750

  10. Special Libraries

    ERIC Educational Resources Information Center

    Lavendel, Giuliana

    1977-01-01

    Discusses problems involved in maintaining special scientific or engineering libraries, including budget problems, remote storage locations, rental computer retrieval systems, protecting trade secrets, and establishing a magnetic tape library. (MLH)

  11. Aging and the Work Force: Human Resource Strategies. An Information Paper Prepared for Use by the Special Committee on Aging. United States Senate, Ninety-Seventh Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This information paper explores the need for age-neutral functional criteria in the human resources management system and the need for managers to review currently accepted employment policies. Population patterns, labor force profiles, and labor force projections are reviewed. The paper examines the effect of retirement policies and considers…

  12. Are Special Education Students Happy?

    ERIC Educational Resources Information Center

    Uusitalo-Malmivaara, Lotta; Kankaanpaa, Paula; Makinen, Tuula; Raeluoto, Tiina; Rauttu, Karoliina; Tarhala, Veera; Lehto, Juhani E.

    2012-01-01

    This study compared the subjective and school-related happiness of 75 11- to 16-year-old special education students to 77 age- and gender-matched mainstream students using two quantitative measures. Additionally, the respondents chose from a list of 12 putative happy makers what they felt increased their happiness. Ten special education students…

  13. The environment of ageing.

    PubMed Central

    Tinker, A

    1997-01-01

    The issue of housing and the wider environment for an ageing population is one where there are many unanswered questions. In this paper a number of key issues are discussed and for each of these the focus is on three aspects. These are the current situation, its reasonableness and what research is needed in order to make decisions about policy and practice. The first three issues relate to the profile of older people themselves and the importance of home to them. The changing profile of older people is not just about an ageing population but also about the growing prominence of those with dementia, women, people from black and ethnic minority groups and one person households, yet little is known about the type of housing which should be provided. Of equal concern is the widening gap between those with a high standard of living (including housing) and those with a low standard of living. The importance of home to older people means that research must focus on how people can be enabled to remain there, and also on the costs, financial and otherwise, to carers and to society. The next three issues relate to the type of housing older people live in and moves in later life. The startling change in the tenure pattern with a growth of owner occupation brings problems as does the decline in social housing. The advantages and disadvantages of the different types of housing--mainstream and specialized--for older people are relatively well known. However the balance between the two needs more research as does that on retirement communities. While it is well known that there are peaks of migration in old age and that moves are often made in haste, little is known about the process of decision making. The final two topics concern links between housing and other aspects of older people's lives. On health more research is needed on temperature, mortality and morbidity, homelessness and accidents and especially on links between services. These topics have implications for planning

  14. Special Reports.

    ERIC Educational Resources Information Center

    Young, Peter R.; And Others

    1994-01-01

    Includes six special reports: "Libraries and the National Information Infrastructure" (Peter R. Young and Jane Williams); "Library Cooperation and Networking" (JoAn Segal); "Mexican Information Resources in Electronic Format" (Shirley Ainsworth); "The International Role of U.S. Librarians" (Hannelore B.…

  15. Special Reports.

    ERIC Educational Resources Information Center

    Wiant, Sarah K.; Lynch, Clifford; Nevins, Kate; Juergens, Bonnie

    1998-01-01

    Contains three special reports: developments in copyright law, 1997 (World Intellectual Property Organization (WIPO) legislation, Ashcroft Bill, No Electronic Theft Act, database protection, Conference on Fair Use (CONFU), judicial decisions, principles for licensing electronic resources, and Uniform Commercial Code Article 2B); Internet2 and the…

  16. Special Advocate.

    ERIC Educational Resources Information Center

    Vander Weele, Maribeth

    1992-01-01

    Thomas Hehir, special education chief of Chicago Public Schools, is evangelist of integrating children with disabilities into regular classrooms. By completely reorganizing department viewed as political patronage dumping ground, Hehir has made remarkable progress in handling large number of children awaiting evaluation and placement in special…

  17. Special Feature.

    ERIC Educational Resources Information Center

    Cox, Gary B., Ed.

    1994-01-01

    The nine articles of this special section focus on the role of evaluation in the reform of the mental health system in Washington. The reform process is described from its inception through its design to the dissemination and utilization of evaluation results. The final article considers implications for statewide evaluations. (SLD)

  18. 76 FR 59133 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Immunodeficiency Virus (HIV) Prevention Projects for Young Men of Color Who Have Sex with Men and Young Transgender..., National Center for HIV, Hepatitis and Sexually Transmitted Diseases Prevention, CDC, 1600 Clifton Road,...

  19. 76 FR 39879 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Immunodeficiency Virus (HIV) Prevention Projects for Young Men of Color Who Have Sex with Men and Young Transgender...: Harriette Lynch, Public Health Analyst, Extramural Programs, National Center for HIV, Hepatitis and...

  20. 77 FR 27460 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... Public Health Research in China RFA GH-12-005, and Conducting Public Health Research in Thailand by the...) announces the aforementioned meeting: Time and Date 12:00 p.m.--4:00 p.m., June 12, 2012 (Closed). Place... Thailand by the Ministry of Public Health (MOPH) FOA GH-11-002.'' Contact Person for More Information:...

  1. 77 FR 30015 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... the Short and Long Term Consequences of Traumatic Brain Injury (TBI) among Children in the United... Consequences of Traumatic Brain Injury (TBI) among Children in the United States, FOA CE12-004.''...

  2. 77 FR 30015 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Traumatic Brain Injury (TBI) in Older Adults Taking Anticoagulants or Platelet Inhibitors, Funding..., discussion, and evaluation of applications received in response to ``Field Triage of Traumatic Brain...

  3. Environmental Impact Assessment--methodology with special emphasis on European pork production.

    PubMed

    Reckmann, K; Traulsen, I; Krieter, J

    2012-09-30

    One of the most discussed topics worldwide is climate change, upon which livestock production is known to have a great environmental impact. There are different methods to measure these environmental impacts, some of which are mentioned in this review. It especially focuses on the method of Life Cycle Assessment (LCA), because it is widely used, of high relevance and good quality. This review highlights a sample of the few published European LCA studies on pork production. These assessments result in an average global warming potential of 3.6 kg CO(2)- eq per kg pork, ranging from 2.6 to 6.3 kg CO(2)- eq per kg pork. Additionally, it illustrates the main limitations of the methodology itself (e.g. data intensiveness, different allocation techniques) and its application in pork production (e.g. limited data availability, use of multiple functional units, varying system boundaries). The missing comparability of various studies arising from a vague standard still represents the main problem in LCA. Therefore, a new standardisation and the development of a more exhaustive database would generate a future trend.

  4. Traditional farming systems of south-central Chile, with special emphasis on agroforestry

    SciTech Connect

    Altieri, M.A.; Farrell, J.

    1984-01-01

    Results are presented from a brief survey made in Nov-Dec 1982. Owners of small farms (up to 12 ha) generally have complex farming systems with a high diversity of enterprises, including the use of trees for a variety of purposes (food, fodder, wood, construction materials, fuel, etc.).

  5. 78 FR 9926 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Expansion and Reproductive Health Care for Women, FOA DP 13-002, initial review. In accordance with Section... to ``Medicaid Expansion and Reproductive Health Care for Women, FOA DP 13-002, initial review... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  6. Analysis of Rail Vehicle Suspension Spring with Special Emphasis on Curving, Tracking and Tractive Efforts

    NASA Astrophysics Data System (ADS)

    Kumbhalkar, M. A.; Bhope, D. V.; Vanalkar, A. V.

    2016-09-01

    The dynamics of the rail vehicle represents a balance between the forces acting between wheel and rail, the inertia forces and the forces exerted by suspension and articulation. Axial loading on helical spring causes vertical deflection at straight track but failures calls to investigate for lateral and longitudinal loading at horizontal and vertical curves respectively. Goods carrying vehicle has the frequent failures of middle axle inner suspension spring calls for investigation. The springs are analyzed for effect of stress concentration due to centripetal force and due to tractive and breaking effort. This paper also discusses shear failure analysis of spring at curvature and at uphill at various speeds for different loading condition analytically and by finite element analysis. Two mass rail vehicle suspension systems have been analyzed for vibration responses analytically using mathematical tool Matlab Simulink and the same will be evaluated using FFT vibration analyzer to find peak resonance in vertical, lateral and longitudinal direction. The results prove that the suspension acquires high repeated load in vertical and lateral direction due to tracking and curving causes maximum stress concentration on middle axle suspension spring as height of this spring is larger than end axle spring in primary suspension system and responsible for failure of middle axle suspension spring due to high stress acquisition.

  7. Cellular and molecular processes of regeneration, with special emphasis on fish fins.

    PubMed

    Nakatani, Yuki; Kawakami, Atsushi; Kudo, Akira

    2007-02-01

    The phenomenon of 'epimorphic regeneration', a complete reformation of lost tissues and organs from adult differentiated cells, has been fascinating many biologists for many years. While most vertebrate species including humans do not have a remarkable ability for regeneration, the lower vertebrates such as urodeles and fish have exceptionally high regeneration abilities. In particular, the teleost fish has a high ability to regenerate a variety of tissues and organs including scales, muscles, spinal cord and heart among vertebrate species. Hence, an understanding of the regeneration mechanism in teleosts will provide an essential knowledge base for rational approaches to tissue and organ regeneration in mammals. In the last decade, small teleost fish such as the zebrafish and medaka have emerged as powerful animal models in which a variety of developmental, genetic and molecular approaches are applicable. In addition, rapid progress in the development of genome resources such as expressed sequence tags and genome sequences has accelerated the speed of the molecular analysis of regeneration. This review summarizes the current status of our understanding of the cellular and molecular basis of regeneration, particularly that regarding fish fins.

  8. Overview on Techniques to Construct Tissue Arrays with Special Emphasis on Tissue Microarrays

    PubMed Central

    Vogel, Ulrich

    2014-01-01

    With the advent of new histopathological staining techniques (histochemistry, immunohistochemistry, in situ hybridization) and the discovery of thousands of new genes, mRNA, and proteins by molecular biology, the need grew for a technique to compare many different cells or tissues on one slide in a cost effective manner and with the possibility to easily track the identity of each specimen: the tissue array (TA). Basically, a TA consists of at least two different specimens per slide. TAs differ in the kind of specimens, the number of specimens installed, the dimension of the specimens, the arrangement of the specimens, the embedding medium, the technique to prepare the specimens to be installed, and the technique to construct the TA itself. A TA can be constructed by arranging the tissue specimens in a mold and subsequently pouring the mold with the embedding medium of choice. In contrast, preformed so-called recipient blocks consisting of the embedding medium of choice have punched, drilled, or poured holes of different diameters and distances in which the cells or tissue biopsies will be deployed manually, semi-automatically, or automatically. The costs of constructing a TA differ from a few to thousands of Euros depending on the technique/equipment used. Remarkably high quality TAs can be also achieved by low cost techniques. PMID:27600339

  9. 76 FR 24030 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... for More Information: Diana Bartlett, M.P.H., Scientific Review Officer, CDC, 1600 Clifton Road, NE., Mailstop D-72, Atlanta, Georgia 30333, Telephone: (404) 639-4938. The Director, Management Analysis...

  10. 75 FR 22815 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Excellence in Youth Violence Prevention (U01), Funding Opportunity Announcement (FOA) CE10-004, Initial... Program for the National Academic Centers of Excellence in Youth Violence Prevention (U01), FOA...

  11. Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis

    PubMed Central

    Toprak, Hüseyin; Kılıç, Erkan; Serter, Aslı; Kocakoç, Ercan; Özgöçmen, Salih

    2014-01-01

    Developments in digital ultrasonography (US) technology and the use of high-frequency broadband transducers have increased the quality of US imaging, particularly of superficial tissues. Thus, US, particularly color US or power Doppler US, in which high-resolution transducers are used, has become an important imaging modality in the assessment of rheumatic diseases. Furthermore, therapeutic interventions and biopsies can be performed under US guidance during the assessment of lesions. In this era of effective treatments, such as biologics, improvements in synovial inflammation in rheumatoid arthritis as well as changes in enthesitis in spondyloarthropathies, including ankylosing spondylitis and psoriatic arthritis, can be monitored effectively using gray-scale and/or power Doppler US. US is also a good imaging modality for crystal arthropathies, including gout and pseudogout, in which synovitis, erosions, tophi, and crystal deposition within or around the joint can be visualized readily. Vascular and tenosynovial structures, as well as the salivary glands, can be assessed with US in vasculitis and connective tissue disorders, including systemic lupus erythematosus and Sjögren’s syndrome. Current research is focused on improving the sensitivity, specificity, validity, and reproducibility of US findings. In this review, we summarized the role of US, particularly power Doppler US, in rheumatic diseases and inflammation in superficial tissues. PMID:23996840

  12. Early Childhood Intervention Partnerships on the Navajo Reservation with an Emphasis on Special Education.

    ERIC Educational Resources Information Center

    Sealander, Karen; Medina, Catherine; Gamble, Armanda; Pettigrew, Bobbie; Snyder, Maria; White, Sherri; Begay, Mary Helen; Bradley, Brian; Bradley-Wilkinson, Evangeline; Heimbecker, Connie; McCarty, Nellie; Nelson, Bernita; Nelson, Jacob; Smith, Jody; Whitehair, Marsha; Redsteer, Denise; Prater, Greg

    Kayenta Unified School District (KUSD) is located in the Navajo Reservation in Arizona. In addition to serving over 2,600 K-12 students, KUSD collaborates with the Navajo Nation and the Kayenta community to provide three early childhood education programs: Acceptance Belonging Caring (ABC) preschool, Navajo Nation Head Start, and Child Care…

  13. Red River of the North Main Stem: Technical Information Report (with Special Emphasis on Agricultural Levees).

    DTIC Science & Technology

    1982-07-01

    18 DISCHARGE-SETBACK CURVE 129 19 DISCHARGE VS. LEVEE HEIGHT CURVE 130 20 SETBACK VS. LEVEE HEIGHT CURVE 131 21 ROTATIONAL LANDSLIDE 135 22 POTENTIAL...ftOO G% F0 OSO -64NDFOK 29L C _z __W- -m-C C -- - -- - - - - :7__ _ __ __ ---- ---- sew -0 n DRY - SL Ir - LV-RA00 3z’ 33~. T-^ = Fiure 2a Naxziumare...bottom and very low river elevation). Landslides of the type in question are usually deep-seated. When the failing earth mass breaks away from the lake

  14. Diving accident management, with special emphasis on the situation in the Red Sea.

    PubMed

    Taher, A

    1999-01-01

    Accident management is a concept commonly misunderstood, frequently confused with accident treatment. The situation in the Sinai and the Red Sea makes a broad definition of the term "management" necessary. Management encompasses the whole spectrum: from recognition of the need for a hyperbaric facility, establishing one, education of dive center management, instructors, boat skippers and deck hands, to actual contingency plans set according to the different geographical sites. The essential elements of communication, oxygen first aid, transportation, and actual recompression therapy or other treatments and follow-up must be included. Furthermore, a link to the international organisations involved with diving accident management is an essential and desired backup.

  15. 77 FR 14806 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... place should read as follows: Place: Crowne Plaza Hotel Atlanta-Airport, 1325 Virginia Avenue, Atlanta, GA 30344, Telephone: (404) 768-6660. Contact Person for More Information: Gregory Anderson, MPH,...

  16. 77 FR 2548 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Grants for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Disease, Disability, and Injury... Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC..., Management Analysis and Services Office, CDC, pursuant to Public Law 92-463. Matters To Be Discussed:...

  17. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy.

    PubMed

    Ornoy, Asher

    2007-07-01

    Reactive oxygen species (ROS) are involved in the etiology of numerous diseases including cardio-vascular diseases and diabetes mellitus. There is evidence that several teratogens affect the developing embryo by increasing its oxidative stress and, because of its relatively weak antioxidant defense, especially at the early stages of organogenesis, result in severe embryonic damage. This mechanism seems to operate in diabetes-induced embryonic damage as well as in the mechanism of teratogenicity caused by ionizing radiation, hypoxia, alcohol and cocaine use and cigarette smoking. We studied the role of oxidative stress in diabetic induced embryopathy, both in vivo and in vitro. Under diabetic condition there was a significant decrease in the activity of endogenous antioxidant enzymes and of vitamins C and E in the embryos and their yolk sacs. The lowest activity was observed in the malformed experimental embryos when compared to experimental embryos without anomalies. Similar results were obtained in the Cohen diabetic rats, where the diabetic prone (CDs) rats were unable to increase their antioxidant enzyme activity in spite of the diabetes. Studies performed by other investigators show similar results. Human and animal studies show that the main mechanism of fetal damage induced by high levels of ionizing irradiation, cocaine and alcohol abuse, hypoxia and cigarette smoking is also by increased embryonic oxidative stress. Similarly, several drugs exert their teratogenic activity via embryonic oxidative stress. Abnormal placentation may also cause enhanced placental oxidative stress, resulting in embryonic death, preeclampsia or congenital anomalies. Inability of the developing embryo to cope with that stress may result in embryonic death and/or congenital anomalies. Animal studies also show that a variety of antioxidants are effective in decreasing the damaging effects of heightened oxidative stress induced by teratogens. Effective antioxidants, which might also be of clinical use, include vitamins C and E, carotenoids, folic acid, as well as synthetic products. Appropriate clinical studies with antioxidants in pregnancies of high risk to develop oxidative stress are needed, since non-toxic antioxidants might prove an efficient and inexpensive way to reduce the rate of some serious and sometimes fatal congenital anomalies.

  18. Passenger car collision fatalities--with special emphasis on collisions with heavy vehicles.

    PubMed

    Björnstig, Ulf; Björnstig, Johanna; Eriksson, Anders

    2008-01-01

    Between 1995 and 2004, 293 passenger car occupants died in collisions with other vehicles in northern Sweden (annual incidence: 3.3 per 100,000 inhabitants, 6.9 per 100,000 cars, or 4.8 per 10(9)km driven); half of these deaths involved heavy vehicles. The annual number of passenger car occupant deaths per 100,000 cars in car-truck/bus collisions has remained unchanged since the 1980s, but in car-car collisions it has decreased to one third of its former level. As crash objects, trucks and buses killed five times as many car occupants per truck/bus kilometer driven as did cars. The collisions were characterized by crashes in the oncoming vehicle's lane, under icy, snowy, or wet conditions; crashes into heavy vehicles generally occurred in daylight, on workdays, in winter, and on 90 and 70 km/h two-lane roads. Head and chest injuries accounted for most of the fatal injuries. Multiple fatal injuries and critical and deadly head injuries characterized the deaths in collisions with heavy vehicles. An indication of suicide was present in 4% of the deaths; for those who crashed into trucks, this percentage was doubled. Among the driver victims, 4% had blood alcohol levels above the legal limit of 0.2g/L. Frontal collision risks might be reduced by a mid-barrier, by building less injurious fronts on trucks and buses, by efficient skid prevention, and by use of flexible speed limits varying with road and light conditions.

  19. Cold Shock Proteins: A Minireview with Special Emphasis on Csp-family of Enteropathogenic Yersinia.

    PubMed

    Keto-Timonen, Riikka; Hietala, Nina; Palonen, Eveliina; Hakakorpi, Anna; Lindström, Miia; Korkeala, Hannu

    2016-01-01

    Bacteria have evolved a number of mechanisms for coping with stress and adapting to changing environmental conditions. Many bacteria produce small cold shock proteins (Csp) as a response to rapid temperature downshift (cold shock). During cold shock, the cell membrane fluidity and enzyme activity decrease, and the efficiency of transcription and translation is reduced due to stabilization of nucleic acid secondary structures. Moreover, protein folding is inefficient and ribosome function is hampered. Csps are thought to counteract these harmful effects by serving as nucleic acid chaperons that may prevent the formation of secondary structures in mRNA at low temperature and thus facilitate the initiation of translation. However, some Csps are non-cold inducible and they are reported to be involved in various cellular processes to promote normal growth and stress adaptation responses. Csps have been shown to contribute to osmotic, oxidative, starvation, pH and ethanol stress tolerance as well as to host cell invasion. Therefore, Csps seem to have a wider role in stress tolerance of bacteria than previously assumed. Yersinia enterocolitica and Yersinia pseudotuberculosis are enteropathogens that can spread through foodstuffs and cause an enteric infection called yersiniosis. Enteropathogenic Yersinia are psychrotrophs that are able to grow at temperatures close to 0°C and thus they set great challenges for the modern food industry. To be able to efficiently control psychrotrophic Yersinia during food production and storage, it is essential to understand the functions and roles of Csps in stress response of enteropathogenic Yersinia.

  20. 77 FR 4048 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... Dengue Epidemiology, Outcomes, and Prevention in Sentinel Surveillance and Research Sites in Puerto Rico... to ``Evaluation of Dengue Epidemiology, Outcomes and Prevention in Sentinel Surveillance and...

  1. 78 FR 6329 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... Study to Evaluate Pregnancy exposureS (BD-STEPS), FOA DD13-003, initial review. In accordance with... received in response to ``Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS), FOA...

  2. 77 FR 21778 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Testing of a Clinic-Based Intervention to Increase Dual Protection against Unintended Pregnancy and STDs... Testing of a Clinic-Based Intervention to Increase Dual Protection against Unintended Pregnancy and...

  3. 76 FR 13414 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... Spread of Influenza and Influenza-Like- Illness (U01), Funding Opportunity Number (FOA) CK11-007, Initial... Influenza and Influenza-like-Illness (U01), FOA CK11-007.'' Contact Person for More Information: Dr....

  4. 76 FR 12361 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Determine of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... Respiratory Illness in Decreasing Influenza Transmission, Funding Opportunity Number (FOA) CK11-007, Initial... Illness in Decreasing Influenza Transmission''] Contact Person for More Information: Dr. Amy...

  5. 77 FR 4047 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ..., Prevention and Treatment of Influenza and Other Respiratory Infections in Ghana, IP12- 001, Studies at the Animal-Human Interface of Influenza and Other Zoonotic Diseases in Vietnam, IP12-002, The Incidence of Community Associated Influenza and Other Respiratory Infections in the United States, IP12-003,...

  6. Numerical Studies of Sub-Grid Scale Processes with Special Emphasis on Discrete Sources.

    NASA Astrophysics Data System (ADS)

    Kasibhatla, Prasad Shanyi

    1988-12-01

    State-of-the-art numerical software packages used to solve differential equations utilize adaptive grid techniques. In these methods, the mesh is refined based on a posteriori error estimates. Due to the large computational time requirements for real time air pollution simulations, it is impractical to use adaptive grids. The aim of this study is to identify parameters which affect the accuracy of numerical solutions of the transport equations involving discrete sources. Based on this a grid can be chosen a priori and used for the entire simulation. Numerical results are presented for a one-dimensional problem in which the discontinuity is in the form of a Dirac delta initial condition. This initial condition is approximated using two approaches, namely, T_2 mollification and L _2 projection. These methods are compared in terms of solution accuracy and rate of convergence. Various time-integration schemes are also tested concurrently. Extensions to two- and three-dimensional problems, with sources occurring as forcing functions, are also presented. A time-split scheme and a finite element scheme are used to solve these problems. Numerical results for inert plumes emanating from discrete sources show that the ratio of the advection time scale to the turbulent diffusion time scale plays a key role in determining solution accuracy. In addition, comparisons between the volume-averaged representation of a point source and the use of an irregular grid for point source representation demonstrate that, near the source, improved results can be obtained by placing a node at the source location. Numerical results also reveal that the cross-derivative term, which appears in the governing differential equation when the wind velocity vector is not aligned along grid lines, can be ignored without significant loss of accuracy.

  7. Fisher's contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy.

    PubMed

    Piegorsch, W W

    1990-12-01

    R. A. Fisher is widely respected for his contributions to both statistics and genetics. For instance, his 1930 text on The Genetical Theory of Natural Selection remains a watershed contribution in that area. Fisher's subsequent research led him to study the work of (Johann) Gregor Mendel, the 19th century monk who first developed the basic principles of heredity with experiments on garden peas. In examining Mendel's original 1865 article, Fisher noted that the conformity between Mendel's reported and proposed (theoretical) ratios of segregating individuals was unusually good, "too good" perhaps. The resulting controversy as to whether Mendel "cooked" his data for presentation has continued to the current day. This review highlights Fisher's most salient points as regards Mendel's "too good" fit, within the context of Fisher's extensive contributions to the development of genetical and evolutionary theory.

  8. 75 FR 55806 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Patient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement... Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement FOA...

  9. 75 FR 39033 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Patient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement...), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement FOA CI10- 003.''...

  10. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review.

    PubMed

    Bandara, Thushari; Uluwaduge, Inoka; Jansz, E R

    2012-05-01

    Cinnamon is the oldest spice and has been used by several cultural practices for centuries. In addition to its culinary uses, cinnamon possesses a rising popularity due to many stated health benefits. Out of the large number of cinnamon species available, Cinnamomum aromaticum (Cassia) and Cinnamomum zeylanicum have been subjected to extensive research. Available in vitro and in vivo evidence indicates that cinnamon may have multiple health benefits, mainly in relation to hypoglycaemic activity. Furthermore, the therapeutic potential of cinnamon is stated also to be brought about by its anti-microbial, anti-fungal, antiviral, antioxidant, anti-tumour, blood pressure-lowering, cholesterol and lipid-lowering and gastro-protective properties. This article provides a summary of the scientific literature available on both C. aromaticum and C. zeylanicum. All studies reported here have used cinnamon bark and its products. Although almost all the animal models have indicated a pronounced anti-diabetic activity of both cinnamon species, conflicting results were observed with regard to the few clinical trials available. Therefore, the necessity of evaluating the effects of cinnamon for its therapeutic potential through well-defined and adequately powered randomized controlled clinical trials is emphasized, before recommendations are made for the use of cinnamon as an effective treatment for humans.

  11. Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review.

    PubMed

    Yimer, Mulat; Hailu, Tadesse; Mulu, Wondemagegn; Abera, Bayeh

    2015-06-01

    Elephantiasis is a symptom of a variety of diseases that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts. Some conditions having this symptom include: Elephantiasis nostras, due to longstanding chronic lymphangitis; Elephantiasis tropica or lymphatic filariasis, caused by a number of parasitic worms, particularly Wuchereria bancrofti; non-filarial elephantiasis or podoconiosis, an immune disease caused by heavy metals affecting the lymph vessels; proteus syndrome, the genetic disorder of the so-called Elephant Man, etc. Podoconiosis is a type of lower limb tropical elephantiasis distinct from lymphatic filariasis. Lymphatic filariasis affects all population at risk, whereas podoconiosis predominantly affects barefoot subsistence farmers in areas with red volcanic soil. Ethiopia is one of the countries with the highest number of podoconiosis patients since many people are at risk to red-clay soil exposure in many parts of the country. The aim of this review was to know the current status and impact of podoconiosis and its relevance to elephantiasis in Ethiopia. To know the epidemiology and disease burden, the literatures published by different scholars were systematically reviewed. The distribution of the disease and knowledge about filarial elephantiasis and podoconiosis are not well known in Ethiopia. It is relatively well studied in southern Ethiopia but data from other parts of the country are limited. Moreover, programmes that focus on diagnosis, treatment, prevention and control of filarial elephantiasis and podoconiosis are also non-existent even in endemic areas. Furthermore, the disease mapping has not been carried out country-wide. Therefore, in order to address these gaps, Ethiopian Ministry of Health needs to take initiative for undertaking concrete research and mapping of the disease in collaboration with stakeholders.

  12. ELECTRIC AND MAGNETIC PROPERTIES OF VERY THIN FILMS WITH SPECIAL EMPHASIS ON SUPERCONDUCTIVITY

    DTIC Science & Technology

    Contents: Critical currents and magnetic fields in thin films Dependence of transition temperature on film thickness (superconductive tunneling) Thermal contact at low temperatures Effect of electrostatic charging on the normal state conductivity and superconducting critical temperature of thin films Microwave transmission and reflection of super conducting films.

  13. New taxa of Carpomyini, with special emphasis on Goniglossum (Diptera: Tephritidae: Trypetinae).

    PubMed

    Freidberg, Amnon

    2016-07-26

    Goniglossum Rondani, hitherto a monobasic genus, is reinstated from synonymy under Carpomya Costa. A second species, Goniglossum liat n. sp., is described nearly two centuries after the description of the first species and 160 years after the description of Goniglossum. G. liat is described from Israel (also known from Turkey) and compared with G. wiedemanni (Meigen), an essentially European species, which is the type-species of Goniglossum and the only other known congener. The two species differ in details of the mesonotal and pleural color pattern (e.g., tip of scutellum with three small black spots in G. wiedemanni, whereas with one large spot in G. liat), structure of the male and female terminalia (e.g., the aculeus of G. wiedemanni is distinctly narrower apically than that of G. liat, and its tip has significantly fewer teeth), and host plant associations (Bryonia alba L. and B. dioica Jacq. are hosts of G. wiedemanni, whereas Bryonia cretica L. and B. syriaca Boiss. are hosts of G. liat). Myiopardalis Bezzi is also reinstated from synonymy under Carpomya. C. tica Norrbom, originally described in Carpomya, is transferred to Norrbomella, new genus, as its type and only included species.

  14. Management of haemophilic pseudotumours with special emphasis on radiotherapy and arterial embolization.

    PubMed

    Espandar, R; Heidari, P; Rodriguez-Merchan, E C

    2009-03-01

    The haemophilic pseudotumour is an expanding destructive haematoma, which is associated with a considerable amount of morbidity in haemophilic patients. Its prevention is paramount. In fact, this goal can be achieved by primary prophylaxis to avoid muscle haematomas and by adequate and long-term haematological treatment of muscle haematomas in case they appear. At the moment, surgical excision of pseudotumour is the preferred treatment by many authors. However, there are instances that surgical extraction of the lesion is not feasible. In such situations, radiotherapy and arterial embolization should be considered either alone or as an adjunct to surgery. Conservative management using a combination of radiotherapy and replacement therapy should be considered for treating haemophilic bone pseudotumours, which are located in the skull or in the distal parts of the limbs, especially in conditions where some impediments to surgical excision exist. In fact, the radiation should be delivered to the lesion site in small fragments of 2 Gy or less to a total dosage of 6-23.5 Gy, which is the most recommended radiation dosage, at the moment. Therapeutic arterial embolization of haemophilic pseudotumours should be considered in lesions of large size, especially in pseudotumours of pelvic region, as it may effectively reduce its size and decrease the risk of bleeding complications during surgery. Nevertheless, in view of its temporary effect, embolization may better be performed, as a preparatory procedure, at best about 2 weeks prior to surgery. This time lapse will allow for mass shrinkage but is insufficient for vessel restoration.

  15. Proper housing conditions in experimental stroke studies—special emphasis on environmental enrichment

    PubMed Central

    Mering, Satu; Jolkkonen, Jukka

    2015-01-01

    Environmental enrichment provides laboratory animals with novelty and extra space, allowing different forms of multisensory stimulation ranging from social grouping to enhanced motor activity. At the extreme end of the spectrum, one can have a super-enriched environment. Environmental enrichment is believed to result in improved cognitive and sensorimotor functions both in naïve rodents and in animals with brain lesions such as those occurring after a stroke. Robust behavioral effects in animals which have suffered a stroke are probably related not only to neuronal plasticity in the perilesional cortex but also in remote brain areas. There is emerging evidence to suggest that testing restorative therapies in an enriched environment can maximize treatment effects, e.g., the perilesional milieu seems to be more receptive to concomitant pharmacotherapy and/or cell therapy. This review provides an updated overview on the effect of an enriched environment in stroke animals from the practical points to be considered when planning experiments to the mechanisms explaining why combined therapies can contribute to behavioral improvement in a synergistic manner. PMID:25870536

  16. An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment.

    PubMed

    Cassano, Nicoletta; Mastrandrea, Valentina; Vestita, Michelangelo; Vena, Gino Antonio

    2009-11-01

    Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.

  17. 77 FR 25485 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... review.'' Contact Person for More Information: Donald Blackman, Ph.D., M.P.H., Scientific Review Officer... and Date: 8:30 a.m.-5:00 p.m., May 15, 2012 (Closed). Place: The Georgian Terrace Hotel, 659 Peachtree... Office, Centers for Disease Control and Prevention. BILLING CODE 4163-18-P...

  18. 76 FR 3908 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Officer, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office of the Director... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and.... L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

  19. 75 FR 13560 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Knowledge...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ...: Donald Blackman, PhD, Scientific Review Officer, National Center for Chronic Disease Prevention and... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces...

  20. 75 FR 77645 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pregnancy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... for Chronic Disease Prevention and Health Promotion, Office of the Director, Extramural Research... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and.... 92-463), the Centers for Disease Control and Prevention (CDC) announces the aforementioned...

  1. 75 FR 77645 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pregnancy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... Center for Chronic Disease Prevention and Health Promotion, Office of the Director, Extramural Research... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and.... 92-463), the Centers for Disease Control and Prevention (CDC) announces the aforementioned...

  2. 75 FR 7281 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Translating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ..., Scientific Review Officer, National Center for Chronic Disease and Health Promotion, Office of the Director... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and...

  3. Cold Shock Proteins: A Minireview with Special Emphasis on Csp-family of Enteropathogenic Yersinia

    PubMed Central

    Keto-Timonen, Riikka; Hietala, Nina; Palonen, Eveliina; Hakakorpi, Anna; Lindström, Miia; Korkeala, Hannu

    2016-01-01

    Bacteria have evolved a number of mechanisms for coping with stress and adapting to changing environmental conditions. Many bacteria produce small cold shock proteins (Csp) as a response to rapid temperature downshift (cold shock). During cold shock, the cell membrane fluidity and enzyme activity decrease, and the efficiency of transcription and translation is reduced due to stabilization of nucleic acid secondary structures. Moreover, protein folding is inefficient and ribosome function is hampered. Csps are thought to counteract these harmful effects by serving as nucleic acid chaperons that may prevent the formation of secondary structures in mRNA at low temperature and thus facilitate the initiation of translation. However, some Csps are non-cold inducible and they are reported to be involved in various cellular processes to promote normal growth and stress adaptation responses. Csps have been shown to contribute to osmotic, oxidative, starvation, pH and ethanol stress tolerance as well as to host cell invasion. Therefore, Csps seem to have a wider role in stress tolerance of bacteria than previously assumed. Yersinia enterocolitica and Yersinia pseudotuberculosis are enteropathogens that can spread through foodstuffs and cause an enteric infection called yersiniosis. Enteropathogenic Yersinia are psychrotrophs that are able to grow at temperatures close to 0°C and thus they set great challenges for the modern food industry. To be able to efficiently control psychrotrophic Yersinia during food production and storage, it is essential to understand the functions and roles of Csps in stress response of enteropathogenic Yersinia. PMID:27499753

  4. Molecular phylogeny of the Herpestidae (Mammalia, Carnivora) with a special emphasis on the Asian Herpestes.

    PubMed

    Patou, Marie-Lilith; McLenachan, Patricia A; Morley, Craig G; Couloux, Arnaud; Jennings, Andrew P; Veron, Géraldine

    2009-10-01

    Until now, phylogenetic studies of the mongooses (Carnivora, Herpestidae) have not included an exhaustive sampling of the Asian members of this family. In this study, we used mitochondrial (Cytochrome b and ND2), nuclear (beta-fibrinogen intron 7 and Transthyretin intron 1) sequences from almost all of the recognized mongoose species to produce a well-resolved phylogeny of the Herpestidae. We also performed molecular dating analyses to infer divergence dates of the different lineages within the Herpestidae. Our results confirmed the paraphyly of the Herpestes genus and other phylogenetic relationships, which previously had only been moderately supported. The Asian herpestid species were found to form a monophyletic group within the Herpestidae. Within the Asian species, a cyto-nuclear conflict was discovered between the small Indian mongoose (Herpestes auropunctatus), the Indian gray mongoose (Herpestes edwardsii) and the Javan mongoose (Herpestes javanicus), which may have occurred through interspecific hybridization. This study inferred an Early Miocene origin for the Herpestidae and a Middle Miocene origin for the Asian mongooses.

  5. Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

    PubMed Central

    Patel, Ashaben; Patel, Mitesh; Yang, Xiaoyan; Mitra, Ashim K.

    2015-01-01

    Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly employed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, pulmonary, and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations. PMID:25106908

  6. 76 FR 71568 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Behavioral Surveillance For Young Men Who Have Sex With Men, Funding Opportunity Announcement (FOA), PS11... 5 U.S.C., and the Determination of the Director, Management Analysis and Services Office, CDC... Young Men Who Have Sex With Men, FOA PS11-0010201SUPP12.'' Contact Person for More Information: Amy...

  7. 76 FR 52330 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Laboratories, 4676 Columbia Parkway, MS C-7, Cincinnati, Ohio 45226, Telephone: (513) 533-8511. The Director... with provisions set forth in Section 552b(c)(4) and (6), Title 5 U.S.C., and the Determination of...

  8. 77 FR 31018 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... Section 552b(c) (4) and (6), Title 5 U.S.C., and the Determination of the Director, Management Analysis... Administrator, Office of Extramural Programs, NIOSH, CDC, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-7, Cincinnati, Ohio 45226, Telephone: (513) 533-8511. The Director, Management Analysis...

  9. 76 FR 28790 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ..., 4676 Columbia Pkwy, MS C-7, Cincinnati, Ohio 45226; Telephone: (513) 533-8511. The Director, Management... provisions set forth in Section 552b(c)(4) and (6), Title 5 U.S.C., and the Determination of the...

  10. 77 FR 12844 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Reducing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... Disabilities, FOA DD12-003, Initial Review In accordance with Section 10(a)(2) of the Federal Advisory... among People with Intellectual Disabilities, FOA DD12-003, initial review.'' Contact Person for...

  11. 77 FR 28393 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... Technical Assistance for Public Health Interventions in Haiti to Support Post Earthquake Reconstruction... Laboratories in Haiti to Support Post Earthquake Reconstruction, Cholera and HIV/AIDS Response, FOA GH12-002... Interventions in Haiti to Support Post Earthquake Reconstruction, Cholera and HIV/AIDS Response, FOA...

  12. 77 FR 25181 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... Technical Assistance To The Ministry Of Public Health Of Haiti To Support Post Earthquake Reconstruction... Assistance To The Ministry Of Public Health Of Haiti To Support Post Earthquake Reconstruction, Cholera...

  13. 78 FR 20319 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Health Interventions in Haiti to Support Post-earthquake Reconstruction, Cholera and HIV/AIDS, FOA GH13... Haiti to Support Post-earthquake Reconstruction, Cholera and HIV/AIDS, FOA GH13- 006, initial...

  14. 78 FR 22268 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panels (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Haiti to Support Post-earthquake Reconstruction, Cholera and HIV/AIDS, FOA GH13-006, initial review... Haiti to Support Post-earthquake Reconstruction, Cholera and HIV/AIDS, FOA GH13-006. Matters To Be... Assistance for Public Health Interventions in Haiti to Support Post-earthquake Reconstruction, Cholera...

  15. 78 FR 9926 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Incentive- based Smoking Cessation for Pregnant Women, FOA DP 13-003, initial review. In accordance with... of the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92-463. Matters... applications received in response to ``Cost-Benefit of Incentive-based Smoking Cessation for Pregnant...

  16. Evolutionary space platform concept study. Volume 2, part A: SASP special emphasis trade studies

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Efforts are in progress to define an approach to provide a simple and cost effective solution to the problem of long duration space flight. This approach involves a Space Platform in low Earth orbit, which can be tended by the Space Shuttle and which will provide, for extended periods of time, stability, utilities and access for a variety of replaceable payloads. The feasibility of an evolutionary space system which would cost effectively support unmanned payloads in groups, using a Space Platform which provides centralized basic subsystems is addressed.

  17. Statistical theory and methodology for remote sensing data analysis with special emphasis on LACIE

    NASA Technical Reports Server (NTRS)

    Odell, P. L.

    1975-01-01

    Crop proportion estimators for determining crop acreage through the use of remote sensing were evaluated. Several studies of these estimators were conducted, including an empirical comparison of the different estimators (using actual data) and an empirical study of the sensitivity (robustness) of the class of mixture estimators. The effect of missing data upon crop classification procedures is discussed in detail including a simulation of the missing data effect. The final problem addressed is that of taking yield data (bushels per acre) gathered at several yield stations and extrapolating these values over some specified large region. Computer programs developed in support of some of these activities are described.

  18. Integrative Therapies in Anxiety Treatment with Special Emphasis on the Gut Microbiome.

    PubMed

    Schnorr, Stephanie L; Bachner, Harriet A

    2016-09-01

    Over the past decade, research has shown that diet and gut health affects symptoms expressed in stress related disorders, depression, and anxiety through changes in the gut microbiota. Psycho-behavioral function and somatic health interaction have often been ignored in health care with resulting deficits in treatment quality and outcomes. While mental health care requires the professional training in counseling, psychotherapy and psychiatry, complimentary therapeutic strategies, such as attention to a nutritional and diverse diet and supplementation of probiotic foods, may be integrated alongside psychotherapy treatment models. Development of these alternative strategies is predicated on experimental evidence and diligent research on the biology of stress, fear, anxiety-related behaviors, and the gut-brain connection. This article provides a brief overview on biological markers of anxiety and the expanding nutritional literature relating to brain health and mental disorders. A case study demonstrates an example of a biopsychosocial approach integrating cognitive psychotherapy, dietary changes, and mindfulness activities, in treating symptoms of anxiety. This case study shows a possible treatment protocol to explore the efficacy of targeting the gut-brain-axis that may be used as an impetus for future controlled studies.

  19. 77 FR 73662 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ...): Initial Review The meeting announced below concerns Occupational Safety and Health Education and Research...., February 27, 2013 (Closed). 8:00 a.m.-12:00 p.m., February 28, 2013 (Closed). Place: Renaissance Atlanta... Health Education and Research Centers (ERC) PAR 10-217.'' Contact Person for More Information:...

  20. A bibliographical survey of bruxism with special emphasis on non-traditional treatment modalities.

    PubMed

    Nissani, M

    2001-06-01

    After proposing a common-sense definition of bruxism, this partial review distills its various symptoms and consequences from the literature. That literature suggests that the splint-the most popular treatment modality-falls short in some respects. The research literature is even less sanguine about the efficacy of such other traditional therapies as sound alarms and stress reduction. Given the limited success of traditional approaches, and given, moreover, the high incidence of bruxism and its harmful consequences, clinicians may occasionally be interested in experimenting with non-intrusive, safe, less widely known, treatment modalities. To meet this need, this review-unlike all other reviews of the subject-focuses on such comparatively unpopular or recent approaches.

  1. Spinal Epidural Abscess: A Review with Special Emphasis on Earlier Diagnosis

    PubMed Central

    Bond, Allison

    2016-01-01

    Spinal epidural abscess (SEA) is an uncommon but serious condition with significant morbidity and mortality. The prognosis of SEA is highly dependent on the timeliness of its diagnosis before neurological deficits develop. Unfortunately, often due to its nonspecific presentation, such as back pain, the diagnosis of SEA may be delayed in up to 75% of cases. Although many risk factors for SEA can be found in the published literature, their utility is limited by their frequent lack of objective evidence, numerousness, and absence in a significant proportion of cases. In this review, we call for a more discriminate evidence-based use of the term “risk factor” when discussing SEA and explore several approaches to its earlier diagnosis, including a simple algorithm based on its pathophysiology and serum C-reactive protein or erythrocyte sedimentation rate. PMID:28044125

  2. Spinal Epidural Abscess: A Review with Special Emphasis on Earlier Diagnosis.

    PubMed

    Bond, Allison; Manian, Farrin A

    2016-01-01

    Spinal epidural abscess (SEA) is an uncommon but serious condition with significant morbidity and mortality. The prognosis of SEA is highly dependent on the timeliness of its diagnosis before neurological deficits develop. Unfortunately, often due to its nonspecific presentation, such as back pain, the diagnosis of SEA may be delayed in up to 75% of cases. Although many risk factors for SEA can be found in the published literature, their utility is limited by their frequent lack of objective evidence, numerousness, and absence in a significant proportion of cases. In this review, we call for a more discriminate evidence-based use of the term "risk factor" when discussing SEA and explore several approaches to its earlier diagnosis, including a simple algorithm based on its pathophysiology and serum C-reactive protein or erythrocyte sedimentation rate.

  3. [Ehlers-Danlos syndrome, with special emphasis in the joint hypermobility syndrome].

    PubMed

    Bravo, Jaime F

    2009-11-01

    There is an urgent need to increase the awareness on the Joint Hyper mobility Syndrome QHS). This is a congenital and prevalent emergent condition that is frequently undiagnosed and that causes significant health problems. Besides recurrent muscular-skeletal problems and signs and symptoms derived from tissue fragility, adolescents and young adults may develop osteoporosis, early osteoarthritis or dysautonomia, that are common in the disease, and deteriorate quality of life. Many JHS patients have signs and symptoms suggestive of fibromyalgia and are usually misdiagnosed. Physicians should be able to differentiate the less severe form of JHS from the Vascular Ehlers-Danlos Syndrome, to diagnose it before the appearance of serious complications and even death. The study of these diseases is a promising area for genomic and rheumatologic research.

  4. A seasonal comparison of zooplankton communities in the Kara Sea - With special emphasis on overwintering traits

    NASA Astrophysics Data System (ADS)

    Kosobokova, Ksenia Nikolaevna; Hirche, Hans-Juergen

    2016-06-01

    Siberian marginal seas cover large parts of the marine Arctic and host unique zooplankton communities. Detailed knowledge of their community structure and life history traits is a prerequisite to predict their response to ongoing and future climate and anthropogenic changes although winter data is extremely rare. Here data are presented from winter samples (February and April) in four biogeographic regions of the Kara Sea. Comparison of community composition and zooplankton abundance/biomass with data collected during summer showed lower diversity in winter, mainly due to the absence of freshwater species. In contrast to many other northern regions, seasonal biomass differences were relatively small. Year-round high biomass is maintained through a large share of small copepod species and constantly high share of the chaetognath Parasagitta elegans. An advanced state of gonad maturation and reproduction was observed in winter in herbivorous, omnivorous, and carnivorous species, e.g. the copepods Calanus glacialis, Drepanopus bungei, Limnocalanus macrurus, Oithona similis, Pseudocalanus major, Pseudocalanus minutus/acuspes, Paraeuchaeta glacialis, Microcalanus pygmaeus, and euphausiids, hydromedusae, and pteropods. Meroplanktonic larvae of nudibranchia, polychaeta and bivalvia were also registered. Close to the Yenisei mouth, abundance of eggs and larvae of various taxa exceeded older stages. Our data show that the brackish-water zone of the Kara Sea hosts specific communities with omnivorous species efficiently exploiting local resources during the winter and utilizing them for winter reproduction.

  5. Results of brachytherapy for cancer of the tongue with special emphasis on local prognosis

    SciTech Connect

    Horiuchi, J.; Okuyama, T.; Shibuya, H.; Takeda, M.

    1982-05-01

    One hundred and sixty-six patients with squamous cell carcinoma of the tongue were treated with radiation. Treatment modalities were mainly interstitial implant with or without external beam irradiation, except for early lesions, which were treated with intraoral electron beam therapy. Analysis was made on the local prognosis of the lesion to clarify the indications for interstitial therapy, especially the combined program with external beam therapy, and the time-dose relationship of the brachytherapy. Local recurrence-free rates (two years) were 94% in T1, 77% in T2 and 32% in T3 lesions, respectively. For T1 and surperficial or exophytic T2 lesions, the local recurrence-free rate was excellent with the interstitial therapy alone using either permanent implants of gold grain or radium implants. Therefore, prior external beam therapy seemed to be unnecessary for these lesions. When the treated area was less than 10 cm/sup 2/, subsequent complications were not likely even if the TDF (time-dose factor) value was high. Most of the patients who received combined external beam and interstitial therapy showed infiltrative T2 and a majority of the T3 lesions. In these patients, it was apparent that most of the total dose should be given from the interstitial implant after a small prior dose with external irradiation, because these lesions could not be cured even if the external dose was increased.

  6. 76 FR 9020 - Disease, Disability, and Injury Prevention and Control; Special Emphasis Panel (SEP): Ability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ...) Technologies To Reduce the Entomological Risk of Lyme Disease, Funding Opportunity Announcement (FOA) CK11-005... (ITM) Technologies To Reduce the Entomological Risk of Lyme Disease, FOA CK11-005.'' Contact Person for... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention...

  7. 78 FR 17412 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... Region of the United States (U01), FOA EH13-001, initial review. SUMMARY: This document corrects a notice... and matters to be discussed should read as follows: The meeting announced below concerns Indoor Environment of Low- Income Renovated Multifamily Housing in the Western Region of the United States (U01),...

  8. Nature conservation in Central and Eastern Europe with a special emphasis on the Carpathian Mountains.

    PubMed

    Oszlányi, Július; Grodzińska, Krystyna; Badea, Ovidiu; Shparyk, Yuriy

    2004-07-01

    The natural environment of the Carpathian Mountains is one of the richest in Europe in terms of species richness and ecological value. In general, these mountains are well preserved and constitute an important part of Europe's nature resources. The Carpathian area, although divided by political and ethnic frontiers, provides an excellent example of the possibility of protection and conservation of natural and cultural heritage. Natural or seminatural forest ecosystems are the most valuable ecosystems together with man-made meadows and pastures. It is expected that the formerly diverse approaches to nature protection will become unified as the Carpathian countries are incorporated into the European Union. In this paper the various forms of nature protection in the individual Carpathian countries (Czech Republic, Slovakia, Poland, Ukraine and Romania) are described.

  9. 78 FR 1212 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... and Prevention of Viral Hepatitis Among Alaska Natives, Funding Opportunity Announcement (FOA) PS13... Hepatitis Among Alaska Natives, FOA PS13-001.'' Contact Person for More Information: Gregory Anderson,...

  10. 77 FR 39498 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... and Effects of Contraception, SIP12-064, Panel G, initial review. In accordance with Section 10(a)(2... Effects of Contraception, SIP12-064, Panel G, initial review.'' Contact Person for More Information:...

  11. 76 FR 28438 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Care Act (ACA): Childhood Obesity Research Funding Opportunity Announcement (FOA) DP11- 007, Panel B... evaluation of ``Affordable Care Act (ACA): Childhood Obesity Research Funding Opportunity Announcement...

  12. Nuclear microscopy in biomedical analysis with special emphasis on clinical metal biology

    NASA Astrophysics Data System (ADS)

    Lindh, Ulf; Frisk, Peter; Nyström, Joakim; Danersund, Antero; Hudecek, Romuald; Lindvall, Anders; Thunell, Stig

    1997-07-01

    Nuclear microscopy based upon developments in high energy ion beam techniques is by now an accepted technique in many fields of research. The advancements into the biomedical field have, however, been slower than expected. A major factor explaining this tendency is the availability of nuclear microscopy. This paper reviews briefly the biomedical work using nuclear microscopy that has been carried out since the 4 th International Conference on Nuclear Microprobe Technology and Applications held in Shanghai. Nuclear microscopy of isolated individual blood cells from patients adversely affected by metal exposure from dental amalgam has been performed both before and after removal of the metallic fillings. The elemental profile of blood cells was more or less normalised after treatment. Some of these results will be presented to illustrate a medical application. Results from bulk analysis by ICP-MS of erythrocytes and plasma before and after treatment will also be presented to illustrate the difference in information content between these two approaches as well as the need for complementary information in solving biomedical problems. As part of a larger study of acute porphyria, nuclear microscopy of blood cells was included among the 78 laboratory tests. The approach in this study was unbiased in the sense that no hypothesis was formulated as to which laboratory parameters would be the most explanatory for health or disease. Multivariate discriminant analysis was applied to the large amounts of data acquired. This approach led to the hypothesis that oxidative stress increased the synthesis of manganese-dependent superoxide dismutase in the mitochondria of polymorphonuclear leukocytes, explaining the increase of manganese in these cells. Antioxidant therapy was therefore applied to a couple of patients with porphyria, however, without clinical success.

  13. 76 FR 24031 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... Improve Vaccination Coverage of Children in Child Care Centers (CCCs) and Preschools, Funding Opportunity... Information Systems, FOA IP11-008; and Effectiveness in an Intervention to Promote a Targeted Vaccination... to ``Strategies to Improve Vaccination Coverage of Children in Child Care Centers (CCCs)...

  14. 76 FR 33304 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Improve Vaccination Coverage of Children in Child Care Centers (CCCs) and Preschools, Funding Opportunity... Information Systems, FOA IP11-008; Effectiveness in an Intervention to Promote a Targeted Vaccination...

  15. 77 FR 5026 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Reasons for Racial/Ethnic Disparities with Completing the HPV Vaccine Series among Adolescent Females... for Racial/Ethnic Disparities with Completing the HPV Vaccine Series among Adolescent Females,...

  16. Ticks status in Central Asia with a special emphasis on Uzbekistan.

    PubMed

    Rasulov, Ilham

    2007-09-01

    Uzbekistan is located between the greatest rivers of Central Asia and shares borders with Kazakhstan to the west and to the north, Kyrgyzstan and Tajikistan to the east, and Afghanistan and Turkmenistan to the south. The climate is severely continental and arid, with hot summers and cold winters. These climatic particularities of Uzbekistan determine the distribution of tick fauna. The Ixodidae family of ticks is represented by 23 species in Uzbekistan. These ticks, as ectoparasites, cause significant damage to the livestock breeding and also serve as carriers of many human and animal diseases. During the last 10 years, more than 30,000 ticks in different regions of Uzbekistan were collected and identified. Analysis showed that cattle are parasitized by 11 species of Ixodidae ticks. The dominating species were Hyalomma anatolicum (34.9%), Hyalomma detritum detritum (31.8%), Boophilus kohlsi (30.7%).

  17. 75 FR 41872 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Surveillance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Diabetes Mellitus With Onset in Childhood and Adolescence, RFA DP 10-001, Initial Review In accordance with..., Natural History, Quality of Care and Outcomes of Diabetes Mellitus with Onset in Childhood and...

  18. 75 FR 13560 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Surveillance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... Diabetes Mellitus With Onset in Childhood and Adolescence, RFA DP 10-001, Initial Review In accordance with..., Quality of Care and Outcomes of Diabetes Mellitus With Onset in Childhood and Adolescence, RFA DP...

  19. Synopsis of wetland functions and values: bottomland hardwoods with special emphasis on eastern Texas and Oklahoma

    USGS Publications Warehouse

    Wilkinson, D.L.; Schneller-McDonald, K.; Olson, R.W.; Auble, G.T.

    1987-01-01

    Bottomland hardwood wetlands are the natural cover type of many floodplain ecosystems in the southeastern United States. They are dynamic, productive systems that depend on intermittent flooding and moving water for maintenance of structure and function. Many of the diverse functions performed by bottomland hardwoods (e.g., flood control, sediment trapping, fish and wildlife habitat) are directly or indirectly valued by humans. Balanced decisions regarding bottomland hardwoods are often hindered by a limited ability to accurately specify the functions being performed by these systems and, furthermore, by an inability to evaluate these functions in economic terms. This report addresses these informational needs. It focuses on the bottomland hardwoods of eastern Texas and Oklahoma, serving as an introduction and entry to the literature. It is not intended to serve as a substitute for reference to the original literature. The first section of the report is a review of the major functions of bottomland hardwoods, grouped under the headings of hydrology, water quality, productivity, detritus, nutrients, and habitat. Although the hydrology of these areas is diverse and complex, especially with respect to groundwater, water storage at high flows can clearly function to attenuate peak flows, with possible reductions in downstream flooding damage. Water moving through a bottomland hardwood system carries with it various organic and inorganic constituents, including sediment, organic matter, nutrients, and pollutants. When waterborne materials are introduced to bottomland hardwoods (from river flooding or upland runoff), they may be retained, transformed, or transported. As a result, water quality may be significantly altered and improved. The fluctuating and flowing water regime of bottomland hardwoods is associated with generally high net primary productivity and rapid fluxes of organic matter and nutrients. These, in turn, support secondary productivity in the bottomland hardwoods and downstream through detrital export. A large number of studies detail the extensive utilization of bottomland hardwoods by animals. Several basic habitat components contribute to this support function, including: 1. Fluctuating water levels and permanent bodies of water, 2. Hard mast (e.g., acorns), 3. Dens and cavities, 4. High soil fertility, 5. Diversity of food and cover, 6. Predominance of woody plant communities, 7. Close proximity of diverse structural features, and 8. Linear features providing movement corridors. The second section of the report focuses on the bottomlands of eastern Texas and Oklahoma, including topics such as climate, soils, water resources, historical perspective, vegetation, and fauna. Considerable attention is given to structural characteristics in this section, in order to provide contrasts with bottomland hardwood ecosystems in other areas. In general, the bottomland hardwoods of eastern Texas and Oklahoma are very similar to those elsewhere in the southeastern United States. Differences include the occurrence and relative importance of some community types and plant species and the greater importance of reservoir construction as a source of bottomland hardwoods loss in eastern Texas and Oklahoma. Again, information on faunal utilization is extensive relative to the information available concerning other functions.

  20. Investigation of Mesoscale Circulations Induced by Surface Processes with Special Emphasis on Carolina Coastal Front

    NASA Astrophysics Data System (ADS)

    Chanumalla, Neeraja R.

    The main focus of this research was to investigate the mesoscale circulations induced by surface processes. For this purpose, two geographical regions were selected. The first region is in mid-latitudes, southeast coast of the United States to study the effects of the Gulf Stream on mesoscale circulations and the associated winter weather features such as coastal fronts. The second region is in tropics, over the Indian sub-continent. The objective is to investigate the effects of surface processes on various spatial scales of the summer monsoon circulation. During the Intensive Observation Period (IOP) 7 (22 February 1986) of the Genesis of Atlantic Lows Experiment (GALE) a persistent coastal front was observed along the Carolina coast. Two convergence zones were observed, one near the shore and the other over the Gulf Stream. The convergence zone near the coastline was weaker than that over the Gulf Stream. The differential surface thermal forcing caused a local circulation over the Gulf Stream. This circulation enhanced the convergence associated with the frontogenesis. A difluence zone was observed in between these two convergence zones. The data collected during the GALE IOP #5 on 10 February 1986 indicated a mesoscale circulation over a Gulf Stream filament. The modeled mesoscale circulation over the filament is in agreement with the observations, suggesting that the mesoscale circulation over the filaments may be an important mechanism in the U.S. east coast cyclogenesis. Also, the results using a three-dimensional mesoscale numerical model indicated the importance of Carolina coastline curvature on the formation of the coastal front. The Noilhan-Planton soil moisture and vegetation parameterization was installed in the NRL/NCSU regional prediction model. The importance of soil moisture and vegetation on the mesoscale coastal front was studied using this coupled three-dimensional model. The results suggest that the ground surface moisture, vegetation and landuse patterns affects significantly, the location, vertical structure and the depth of the coastal front. Also, several other mesoscale phenomena such as the low level jet associated with the Carolina coastal front are closer to observations using the soil moisture. Sensitivity of monsoon rainfall to different ambient wind speeds, orography and wind shear was studied using a two-dimensional mesoscale model. The two-dimensional simulations show the existence of a sea-breeze type of mesoscale circulation over the Western Ghats during the monsoon season. This circulation enhances precipitation. NRL/NCSU three dimensional nested model was used to investigate the sensitivity of summer monsoon circulations to the soil moisture and vegetation characteristics. The results indicated that vegetation, soil types and initial soil moisture availability affect the mesoscale variation and the amount of monsoon rainfall significantly. Enhanced mesoscale circulations in the model with vegetation increased convection which in turn increased the magnitude of the upper tropospheric easterly jet.

  1. Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

    PubMed Central

    Saba, Ain Us; Nawazish, Shamyla; Akhtar, Fahad; Rashid, Rehana; Mir, Sadullah; Nasir, Bushra; Afzal, Samina; Pervaiz, Fahad

    2017-01-01

    Over the past few years, considerable attention has been focused on carrageenan based bionanocomposites due to their multifaceted properties like biodegradability, biocompatibility, and nontoxicity. Moreover, these composites can be tailored according to the desired purpose by using different nanofillers. The role of ferromagnetic nanoparticles in drug delivery is also discussed here in detail. Moreover, this article also presents a short review of recent research on the different types of the carrageenan based bionanocomposites and applications. PMID:28303171

  2. Role of cyclic AMP in pulmonary xenobiotic metabolism with special emphasis on benzo(a)pyrene

    SciTech Connect

    Schaeffer, V.H.

    1986-01-01

    This thesis was intended to investigate the role of the intracellular regulator, cAMP, on pulmonary xenobiotic metabolism using the well-studied carcinogen, benzo(a)pyrene (BP) as a representative xenobiotic. Lung slices from rats administered N/sup 6/, O/sup 2/', dibutyryl cAMP (DcAMP), theophylline or forskolin, all of which elevated biologically reactive cAMP levels in the lung, showed an increased ability to metabolize (/sup 3/H)-BP. This effect occurred beyond 6 hr following treatment and reached a maximum at 12 hr, at a time when cAMP content had already peaked and returned to basal levels. The perfusion of BP through the isolated lungs of animals administered DcAMP in vivo indicated that the BP metabolites primarily responsible for the cyclic nucleotide-induced increase in metabolism were the 3-hydroxy BP, 9-hydroxy BP, BP 9, 10 diol, BP-glucuronides and BP-glutathione conjugates. Kinetic analysis indicated that the Km component of these reactions was altered without a corresponding change in Vmax, suggesting that elevated pulmonary cAMP content may be affecting the detoxication enzymes, UDP-glucuronyltransferase and sulfotransferase. Studies with pulmonary microsomes from DcAMP-treated animals indicated that the cyclic nucleotide not only enhanced the hydroxylation of BP but also the cytochrome P450-dependent hydroxylation of coumarin. This is supported by the fact that DcAMP administration in vivo also enhanced phosphorylation of two classes of nuclear proteins, histones and nuclear acidic proteins, believed to play a role in the transcription of RNA and DNA.

  3. 78 FR 35035 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... NE., Atlanta, Georgia 30308. Status: The meeting will be closed to the public in accordance with..., D.V.M., Ph.D., Scientific Review Officer, CDC, 1600 Clifton Road NE., Mailstop K72, Atlanta,...

  4. 78 FR 60875 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Road, Atlanta, Georgia 30333, Telephone: (404) 639-6000. ] Status: The meeting will be closed to the... Clifton Road, Mailstop E-74, Atlanta, Georgia 30333, Telephone: (404) 498-2506. The Director,...

  5. 78 FR 60877 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ..., Atlanta, Georgia 30333, Telephone: (404) 639-6000. Status: The meeting will be closed to the public in..., Mailstop E-74, Atlanta, Georgia 30333, Telephone: (404) 498-2506. The Director, Management Analysis...

  6. 77 FR 61756 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ...). Place: Marriott Century Center, 2000 Century Boulevard, NE., Atlanta, Georgia 30345, Telephone: (404)325... Karr, Ph.D., Scientific Review Officer, CDC/NIOSH 1600 Clifton Road, Mailstop E-74, Atlanta,...

  7. 77 FR 2549 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Grants for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... aforementioned SEP: Time and Date: 8:30 a.m.-5 p.m., February 21-22, 2012 (Closed). Place: Crowne Plaza Atlanta Perimeter Hotel at Ravinia, 4355 Ashford Dunwoody Road, Atlanta, Georgia 30346 Telephone: (770) 395- 7700..., Ph.D., M.P.H., Scientific Review Officer, CDC, 4770 Buford Highway NE., Mailstop F63,...

  8. 76 FR 67458 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... place should read as follows: Place: Sheraton Gateway Hotel Atlanta Airport, 1900 Sullivan Road, Atlanta, Georgia 30337, Telephone: (770) 997-1100. Contact Person For More Information: Amy Yang, Ph.D., Scientific Review Officer, CDC, 1600 Clifton Road NE., Mailstop E60, Atlanta, Georgia 30333, Telephone: (404)...

  9. 77 FR 19018 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... meeting announced below concerns Conducting Public Health Research in South Africa, Funding Opportunity... South Africa, FOA GH12-004.'' Contact Person for More Information: Lata Kumar, Scientific Review...

  10. 78 FR 17412 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... Diseases in Africa, FOA GH13-002, initial review. In accordance with Section 10(a)(2) of the Federal... and Evaluation of Programs for the Elimination and Control of Neglected Tropical Diseases in...

  11. Histology, Immunohistochemistry and Ultrastructure of the Bovine Palatine Tonsil with Special Emphasis on Reticular Epithelium

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The paired palatine tonsils are located at the junction of the nasopharynx and oropharynx; ideally positioned to sample antigens entering through either the nasal cavity or oral cavity. Entering antigens will first contact tonsilar epithelium. To better understand the cellular and functional composi...

  12. Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention.

    PubMed

    ten Cate, J M

    1997-10-01

    Low concentrations of fluoride have a beneficial effect on enamel and dentin de- and remineralization. After fluoride treatments, such as topical applications, rinses or dentifrices, salivary fluoride concentrations decrease exponentially in a biphasic manner to very low concentrations within a few hours. For treatments to be effective over periods longer than the brushing and the following salivary clearance, fluoride needs to be deposited and slowly released. Calcium fluoride (or like) deposits act in such a way, owing to a surface covering of phosphate and/or proteins, which makes the CaF2 less soluble under in vivo conditions than in a pure form in inorganic solutions. Moreover, due to the phosphate groups on the surface of the calcium fluoride globules, fluoride is assumed to be released with decreasing pH when the phosphate groups are protonated in the dental plaque.

  13. 77 FR 12844 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... Intervention for Changing Behaviors Related to Cytomegalovirus Transmission in Pregnant Women, FOA DD12-005... and Brief Intervention for Changing Behaviors Related to Cytomegalovirus Transmission in...

  14. Neuropeptides as possible targets in sleep disorders: special emphasis on hypocretin-deficient narcolepsy.

    PubMed

    Fujiki, Nobuhiro; Nishino, Seiji

    2007-02-01

    Sleep disorders are disturbances of usual sleep patterns or behaviors caused by deregulation of neuronal synchronicity and of the balance of the neurotransmitter system involved in sleep regulation. Insomnia and hypersomnia are frequent sleep disorders, and these are most often treated pharmacologically with hypnotics and wake-promoting compounds. These compounds act on classical neurotransmitter systems, such as benzodiazepines on gamma amino butyric acid (GABA)(A) receptors, and amphetamine-like stimulants on monoaminergic terminals to modulate neurotransmission. In addition, acetylcholine, amino acids, lipids and proteins (cytokines) and peptides, are known to significantly modulate sleep, and thus, are possibly involved in the pathophysiology of some sleep disorders. Due to recent developments in molecular biological techniques, many neuropeptides have been newly identified, and some are found to significantly modulate sleep. Recent discoveries also include the finding that the impairment of hypocretin/orexin neurotransmission (a recently isolated hypothalamic neuropeptide and receptor system), is the major pathophysiology of narcolepsy with cataplexy. A hypocretin replacement therapy is anticipated to reverse the disease symptoms in humans. In this article, we will review the history of neuropeptide research, sleep modulatory effects of various neuropeptides, and the general strategies for the pharmacological therapeutics targeting the peptidergic systems by referring to hypocretin-deficient narcolepsy as an immediate example.

  15. 78 FR 19489 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ...-067; and Feasibility Study of the New Clinical Measure of Colorectal Cancer Screening for Federally... Colorectal Cancer Screening among Asian Subgroups, SIP13-067; and Feasibility Study of the New...

  16. 76 FR 4703 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pregnancy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and..., Scientific Review Officer, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office... and Prevention and the Agency for Toxic Substances and Disease Registry. Dated: January 20,...

  17. 76 FR 12122 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and...., Scientific Review Officer, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office... and Prevention and the Agency for Toxic Substances and Disease Registry. Dated: February 25,...

  18. 75 FR 78997 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Pilot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the..., Scientific Review Officer, CDC, National Center for Chronic Disease Prevention and Health Promotion,...

  19. 76 FR 20355 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... Center for Chronic Disease Prevention and Developmental Disabilities, CDC, 1600 Clifton Road, NE... and Prevention and the Agency for Toxic Substances and Disease Registry. ] Dated: March 31,...

  20. 76 FR 19995 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and... (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the aforementioned... Center for Chronic Disease Prevention and Health Promotion, CDC, 1600 Clifton Road, NE., Mailstop...