The Basolateral Amygdala Can Mediate the Effects of Fear Memory on Sleep Independently of Fear Behavior and the Peripheral Stress Response

PubMed Central

Wellman, Laurie L.; Fitzpatrick, Mairen E.; Hallum, Olga Y.; Sutton, Amy M.; Williams, Brook L.; Sanford, Larry D.

2016-01-01

Fear conditioning associated with inescapable shock training (ST) and fearful context re-exposure (CR) alone can produce significant behavioral fear, a stress response and alterations in subsequent REM sleep. These alterations may vary among animals and are mediated by the basolateral nucleus of the amygdala (BLA). Here, we used the GABAA agonist, muscimol (Mus), to inactivate BLA prior to CR and examined the effects on sleep, freezing and stress-induced hyperthermia (SIH). Wistar rats (n=28) were implanted with electrodes for recording sleep, data loggers for recording core body temperature, and with cannulae aimed bilaterally into BLA. After recovery, the animals were habituated to the injection procedure and baseline sleep was recorded. On experimental day 1, rats received ST (20 footshocks, 0.8mA, 0.5s duration, 60s interstimulus interval). On experimental day 7, the rats received microinjections (0.5ul) into BLA of either Mus (1.0uM; n = 13) or vehicle (Veh; n = 15) prior to CR (CR1). On experimental day 21, the animals experienced a second CR (CR2) without Mus. For analysis, the rats were separated into 4 groups: (Veh-vulnerable (Veh-Vul; n=8), Veh-resilient (Veh-Res; n=7), Mus-vulnerable (Mus-Vul; n=7), and Mus-resilient (Mus-Res; n=6)) based on whether or not REM was decreased, compared to baseline, during the first 4 h following ST. Pre-CR1 inactivation of BLA did not alter freezing or SIH, but did block the reduction in REM in the Mus-Vul group compared to the Veh-Vul group. These data indicate that BLA is an important region for mediating the effects of fearful memories on sleep. PMID:27818268

Chromium Isotope Behaviour During Aerobic Microbial Reduction Activities

NASA Astrophysics Data System (ADS)

Zhang, Q.; Amor, K.; Porcelli, D.; Thompson, I.

2014-12-01

Microbial activity is a very important, and possibly even the dominant, reduction mechanism for many metals in natural water systems. Isotope fractionations during microbial metal reduction can reflect one major mechanism in metal cycling in the environment, and isotopic signatures can be used to identify and quantify reduction processes during biogeochemical cycling in the present environment as well as in the past. There are many Cr (VI)-reducing bacteria that have been discovered and isolated from the environment, and Cr isotopes were found to be fractionated during microbial reduction processes. In this study, Cr reduction experiments have been undertaken to determine the conditions under which Cr is reduced and the corresponding isotope signals that are generated. The experiments have been done with a facultative bacteria Pseudomonas fluorescens LB 300, and several parameters that have potential impact on reduction mechanisms have been investigated. Electron donors are important for bacteria growth and metabolism. One factor that can control the rate of Cr reduction is the nature of the electron donor. The results show that using citrate as an electron donor can stimulate bacteria reduction activity to a large extent; the reduction rate is much higher (15.10 mgˑL-1hour-1) compared with experiments using glucose (6.65 mgˑL-1ˑhour-1), acetate (4.88 mgˑL-1hour-1) or propionate (4.85 mgˑL-1hour-1) as electron donors. Groups with higher electron donor concentrations have higher reduction rates. Chromium is toxic, and when increasing Cr concentrations in the medium, the bacteria reduction rate is also higher, which reflects bacteria adapting to the toxic environment. In the natural environment, under different pH conditions, bacteria may metabolise in different ways. In our experiments with pH, bacteria performed better in reducing Cr (VI) when pH = 8, and there are no significant differences between groups with pH = 4 or pH = 6. To investigate this further, Cr isotope determinations will be presented, which are essential in better understanding bacterial reducing activities under different environmental conditions and can also provide important background information for interpreting Cr isotope fractionations in natural environment, and using Cr isotopes to identify reduction by microbial activity.

Transdermal Patch of Rotigotine Attenuates Freezing of Gait in Patients with Parkinson's Disease: An Open-Label Comparative Study of Three Non-Ergot Dopamine Receptor Agonists.

PubMed

Ikeda, Ken; Hirayama, Takehisa; Takazawa, Takanori; Kawabe, Kiyokazu; Iwasaki, Yasuo

Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients. Methods Rotigotine (maintenance doses of 9-27 mg/day) was administered in 51 patients, 36 patients received pramipexole LA (1.5-4.5 mg/day) and 35 patients received ropinirole CR (8-16 mg/day). The Unified PD Rating Scale (UPDRS) parts I-IV, FOG questionnaire (16 items) and wearing off time were examined from baseline to 7 months after DA administration. UPDRS parts I-IV were evaluated during on time and FOG was recorded during off time if patients experienced wearing off. Results A total of 111 patients completed the study. UPDRS parts II-III scores and wearing off time were significantly reduced after each DA treatment compared to baseline. FOG was found in 54 patients (49%). Most patients developed FOG during off time only. FOG scores were significantly decreased at 2 months after rotigotine treatment whereas pramipexole LA and ropinirole treatment did not alter FOG scores. Conclusion The present study indicates that transdermal patch of rotigotine attenuated the FOG off time. The similar binding affinities to dopamine receptors between rotigotine and dopamine, and 24 hours steady hemodynamics could contribute to the therapeutic mechanism of rotigotine on FOG in PD patients with wearing off.

Transdermal Patch of Rotigotine Attenuates Freezing of Gait in Patients with Parkinson's Disease: An Open-Label Comparative Study of Three Non-Ergot Dopamine Receptor Agonists

PubMed Central

Ikeda, Ken; Hirayama, Takehisa; Takazawa, Takanori; Kawabe, Kiyokazu; Iwasaki, Yasuo

2016-01-01

Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients. Methods Rotigotine (maintenance doses of 9-27 mg/day) was administered in 51 patients, 36 patients received pramipexole LA (1.5-4.5 mg/day) and 35 patients received ropinirole CR (8-16 mg/day). The Unified PD Rating Scale (UPDRS) parts I-IV, FOG questionnaire (16 items) and wearing off time were examined from baseline to 7 months after DA administration. UPDRS parts I-IV were evaluated during on time and FOG was recorded during off time if patients experienced wearing off. Results A total of 111 patients completed the study. UPDRS parts II-III scores and wearing off time were significantly reduced after each DA treatment compared to baseline. FOG was found in 54 patients (49%). Most patients developed FOG during off time only. FOG scores were significantly decreased at 2 months after rotigotine treatment whereas pramipexole LA and ropinirole treatment did not alter FOG scores. Conclusion The present study indicates that transdermal patch of rotigotine attenuated the FOG off time. The similar binding affinities to dopamine receptors between rotigotine and dopamine, and 24 hours steady hemodynamics could contribute to the therapeutic mechanism of rotigotine on FOG in PD patients with wearing off. PMID:27725534

5-HT7 receptor activation: procognitive and antiamnesic effects.

PubMed

Meneses, A; Perez-Garcia, G; Liy-Salmeron, G; Ponce-López, T; Lacivita, E; Leopoldo, M

2015-02-01

The serotonin (5-hydroxytryptamine (5-HT)) 5-HT7 receptor is localized in brain areas mediating memory; however, the role of this receptor on memory remains little explored. First, demonstrating the associative nature of Pavlovian/instrumental autoshaping (P/I-A) task, rats were exposed (three sessions) to CS-US (Pavlovian autoshaping), truly random control, free operant, and presentations of US or CS, and they were compared with rats trained-tested for one session to the P/I-A procedure. Also, effects of the 5-HT7 receptor agonist LP-211 administered intraperitoneally after training was determined on short- (1.5 h) and long-term memory 24 and 48 h) and on scopolamine-induced memory impairment and cAMP production. Autoshaping and its behavioral controls were studied. Other animals were subjected to an autoshaping training session and immediately afterwards were given (intraperitoneal) vehicle or LP-211 (0.1-10 mg/kg) and/or scopolamine (0.2 mg/kg) and tested for short-term memory (STM) and long-term memory (LTM); their brains were extracted for the cAMP ELISA immunoassay. P/I-A group produced the higher %CR. LP-211 did not affect STM; nonetheless, at 0.5 and 1.0 mg/kg, it improved LTM. The 5-HT7 receptor antagonist SB-269970 (SB; 10.0 mg/kg) alone had no effect; nevertheless, the LP-211 (1.0 mg/kg) LTM facilitation was reversed by SB. The scopolamine (0.2 mg/kg) induced-decrement in CR was accompanied by significant increased cAMP production. The scopolamine-induced decrement in CR and increments in cAMP were significantly attenuated by LP-211. Autoshaping is a reliable associative learning task whose consolidation is facilitated by the 5-HT7 receptor agonist LP-211.

Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats

PubMed Central

Thorn, David A; Qiu, Yanyan; Zhang, Yanan; Li, Jun-Xu

2015-01-01

The imidazoline I2 receptor is an emerging drug target for analgesics. This study extended previous studies by examining the antinociceptive effects of three I2 receptor agonists (2-BFI, BU224 and CR4056) in the formalin test. The receptor mechanisms and anatomical mediation of I2 receptor agonist-induced antinociception were also examined. Formalin-induced flinching responses (2%, 50µl) were quantified after treatment with I2 receptor agonists alone or in combination with the I2 receptor antagonist idazoxan. Anatomical mediation was studied by locally administering 2-BFI into the plantar surface or into the right lateral ventricle via cannulae (i.c.v). The locomotor activity was also examined after central (i.c.v.) administration of 2-BFI. 2-BFI (1–10 mg/kg, i.p.) and BU224 (1–10 mg/kg, i.p.) attenuated the spontaneous flinching response observed during 10 min (phase 1) and 20–60 min (phase 2) following formalin treatment, while CR4056 (1–32 mg/kg, i.p.) only decreased phase 2 flinching response. The I2 receptor antagonist idazoxan attenuated the antinociceptive effects of 2-BFI and BU224 during phase 1, but not phase 2. Peripheral administration of 2-BFI (1–10 mg/kg, i.pl) to the hindpaw of rats had no antinociceptive effects. In contrast, centrally delivered 2-BFI (10–100 µg, i.c.v.) dose-dependently attenuated phase 1 and phase 2 flinching at doses that did not reduce the locomotor activity. Together, these data revealed the differential antinociceptive effects of I2 receptor agonists and the differential antagonism profiles by idazoxan, suggesting the involvement of different I2 receptor subtypes in reducing different phases of formalin-induced pain-like behaviors. In addition, the results also suggest the central mediation of I2 receptor agonist-induced antinociceptive actions. PMID:26599907

Activation of Transient Receptor Potential Ankyrin-1 (TRPA1) in Lung Cells by Wood Smoke Particulate Material

PubMed Central

Shapiro, Darien; Deering-Rice, Cassandra E.; Romero, Erin G.; Hughen, Ronald W.; Light, Alan R.; Veranth, John M.; Reilly, Christopher A.

2013-01-01

Cigarette smoke, diesel exhaust, and other combustion-derived particles activate the calcium channel transient receptor potential ankyrin-1 (TRPA1), causing irritation and inflammation in the respiratory tract. It was hypothesized that wood smoke particulate and select chemical constituents thereof would also activate TRPA1 in lung cells, potentially explaining the adverse effects of wood and other forms of biomass smoke on the respiratory system. TRPA1 activation was assessed using calcium imaging assays in TRPA1-overexpressing HEK-293 cells, mouse primary trigeminal neurons, and human adenocarcinoma (A549) lung cells. Particles from pine and mesquite smoke were less potent agonists of TRPA1 than an equivalent mass concentration of an ethanol extract of diesel exhaust particles; pine particles were comparable in potency to cigarette smoke condensate, and mesquite particles were the least potent. The fine particulate (PM<2.5 μm) of wood smoke were the most potent TRPA1 agonists and several chemical constituents of wood smoke particulate: 3,5-ditert-butylphenol, coniferaldehyde, formaldehyde, perinaphthenone, agathic acid, and isocupressic acid were TRPA1 agonists. Pine particulate activated TRPA1 in mouse trigeminal neurons and A549 cells in a concentration-dependent manner, which was inhibited by the TRPA1 antagonist HC-030031. TRPA1 activation by wood smoke particles occurred through the electrophile/oxidant-sensing domain (i.e., C621/C641/C665/K710), based on the inhibition of cellular responses when the particles were pre-treated with glutathione; a role for the menthol-binding site of TRPA1 (S873/T874) was demonstrated for 3,5-ditert-butylphenol. This study demonstrated that TRPA1 is a molecular sensor for wood smoke particulate and several chemical constituents thereof, in sensory neurons and A549 cells, suggesting that TRPA1 may mediate some of the adverse effects of wood smoke in humans. PMID:23541125

Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy.

PubMed

Morote, Juan; Comas, Inma; Planas, Jacques; Maldonado, Xavier; Celma, Ana; Placer, José; Ferrer, Roser; Carles, Joan; Regis, Lucas

2018-04-01

Serum testosterone measurement is recommended to assess the efficacy of androgen deprivation therapy (ADT) and to diagnose castration resistance in patients with prostate cancer (PCa). Currently, the accepted castrate level of serum testosterone is 50 ng/dL. Liquid chromatography and tandem mass spectrometry (LC MSMS) is the appropriate method to measure testosterone, especially at low levels. However, worldwide, chemiluminescent assays (CLIAs) are used in clinical laboratories, despite their lack of accuracy and reproducibility, because they are automatable, fast, sensitive, and inexpensive. We compared serum testosterone levels measured using LC MSMS and CLIAs in 126 patients with PCa undergoing luteinizing hormone-releasing hormone (LHRH) agonist therapy. The median serum testosterone level was 14.0 ng/dL (range, 2.0-67.0 ng/dL) with LC MSMS and 31.9 ng/dL (range, 10.0-91.6 ng/dL) with CLIA (P < .001). The serum testosterone levels, measured using LC MSMS, were < 20 ng/dL in 83 patients (65.9%), 20 to 50 ng/dL in 40 (31.7%), and > 50 ng/dL in 3 patients (2.4%). These ranges were found in 34 (27%), 72 (57.1%), and 20 (15.9%) patients when testosterone was measured using CLIA (P < .001). The castrate level of serum testosterone using LC MSMS and CLIA was 39.8 ng/dL (95% confidence interval [CI], 37.1-43.4 ng/dL) and 66.5 ng/dL (95% CI, 62.3-71.2 ng/dL), respectively. We found that CLIA overestimated the testosterone levels in PCa patients undergoing LHRH agonist therapy. Thus, the castration level was incorrectly considered inadequate with CLIA in almost 15% of patients. The true castration level of serum testosterone using an appropriate method is < 50 ng/dL. Copyright © 2017 Elsevier Inc. All rights reserved.

5-HT2C Receptor Desensitization Moderates Anxiety in 5-HTT Deficient Mice: From Behavioral to Cellular Evidence

PubMed Central

Martin, Cédric BP; Martin, Vincent S.; Trigo, José M.; Chevarin, Caroline; Maldonado, Rafael; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence

2015-01-01

Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is little in vivo data documenting antidepressant-induced 5-HT2CR desensitization in specific brain areas. Methods: Mice lacking the 5-HT reuptake carrier (5-HTT-/-) were used to model the consequences of chronic 5-HT reuptake inhibition with antidepressant drugs. The effect of this mutation on 5-HT2CR was evaluated at the behavioral (social interaction, novelty-suppressed feeding, and 5-HT2CR–induced hypolocomotion tests), the neurochemical, and the cellular (RT-qPCR, mRNA editing, and c-fos–induced expression) levels. Results: Although 5-HTT-/- mice had an anxiogenic profile in the novelty-suppressed feeding test, they displayed less 5-HT2CR–mediated anxiety in response to the agonist m-chlorophenylpiperazine in the social interaction test. In addition, 5-HT2CR–mediated inhibition of a stress-induced increase in 5-HT turnover, measured in various brain areas, was markedly reduced in 5-HTT-/- mutants. These indices of tolerance to 5-HT2CR stimulation were associated neither with altered levels of 5-HT2CR protein and mRNA nor with changes in pre-mRNA editing in the frontal cortex. However, basal c-fos mRNA production in cells expressing 5-HT2CR was higher in 5-HTT-/- mutants, suggesting an altered basal activity of these cells following sustained 5-HT reuptake carrier inactivation. Furthermore, the increased c-fos mRNA expression in 5-HT2CR–like immune-positive cortical cells observed in wild-type mice treated acutely with the 5-HT2CR agonist RO-60,0175 was absent in 5-HTT-/- mutants. Conclusions: Such blunted responsiveness of the 5-HT2CR system, observed at the cell signaling level, probably contributes to the moderation of the anxiety phenotype in 5-HTT-/- mice. PMID:25522398

Cholecystokinin receptors on gallbladder muscle and pancreatic acinar cells: a comparative study

DOE Office of Scientific and Technical Information (OSTI.GOV)

von Schrenck, T.; Moran, T.H.; Heinz-Erian, P.

1988-10-01

To compare receptors for cholecystokinin (CCK) in pancreas and gallbladder, we measured binding of 125I-Bolton-Hunter-labeled CCK-8 (125I-BH-CCK-8) to tissue sections from guinea pig gallbladder and pancreas under identical conditions. In both tissues, binding had similar time-, temperature-, and pH dependence, was reversible, saturable and inhibited only by CCK related peptides or CCK receptor antagonists. Autoradiography localized 125I-BH-CCK-8 binding to the smooth muscle layer in the gallbladder. Binding of 125I-BH-CCK-8 to gallbladder sections was inhibited by various agonists with the following potencies (IC50):CCK-8 (0.4 nM) greater than des(SO3)CCK-8 (0.07 microM) greater than gastrin-17-I (1.7 +/- 0.3 microM) and by various receptormore » antagonists with the following potencies: L364,718 (1.5 nM) greater than CR 1409 (0.19 microM) greater than asperlicin = CBZ-CCK-(27-32)-NH2 (1 microM) greater than Bt2cGMP (120 microM). Similar potencies were found for the agonists and antagonists for pancreas sections. Inhibition of binding of 125I-BH-CCK-8 by 11 different analogues of proglumide gave similar potencies for both pancreas and gallbladder. The potencies of agonists in stimulating and antagonists in inhibiting CCK-stimulated contraction or amylase release correlated closely with their abilities to inhibit 125I-BH-CCK-8 binding to gallbladder or pancreas sections or acini, respectively. The present results demonstrate and characterize a method that can be used to compare the CCK receptors in guinea pig gallbladder and pancreas under identical conditions. Moreover, this study demonstrates that gallbladder and pancreatic CCK receptors have similar affinities for the various agonists and antagonists tested and, therefore, provides no evidence that they represent different subtypes of CCK receptors that can be distinguished pharmacologically.« less

Isoproterenol exacerbates hyperglycemia and modulates chromium distribution in mice fed with a high fat diet.

PubMed

Chang, Geng-Ruei; Chen, Wen-Kai; Hou, Po-Hsun; Mao, Frank Chiahung

2017-12-01

Isoproterenol (ISO), a nonselective β-adrenoceptor agonist for treating bradycardia and asthma, has been proposed to raise blood glucose level. Little is known regarding the relationship between ISO treatment, the induced chromium (Cr) redistribution, and changes in glucose metabolism. We aimed to characterize the effects of a single dose of ISO on glucose homeostasis and Cr level changes in an obesity mouse model. Mice (C57BL6/j strain) were first fed for a continuous period of 12 weeks with either a high fat diet (HFD), to develop an obesity animal model, or a standard diet (SD), to develop a lean animal model as controls. These groups were each separated into two subgroups to receive either a single dose of ISO or saline (control). We measured in vivo their metabolic parameters, fasting glucose level, area under the curve (AUC) for glucose level time profile, insulin level time profile, insulin sensitivity index, and chromium distribution. After a single dose of ISO, the SD-fed mice had slightly higher blood glucose levels compared with the SD controls, when the level was measured 30 and 60min after injection. By contrast, the ISO-treated HFD-fed mice had significantly higher blood glucose levels and AUC during the entire 120min following one administration compared with the HFD control group. Additionally, they had a substantially lower HOMA-IR index, whereas insulin levels remained unchanged. The Cr level in their bones and liver was decreased, and loss of Cr through urinary excretion was elevated. The results demonstrated that ISO exacerbated hyperglycemic syndrome in the obesity animal model. ISO induced a net negative Cr balance as a result of increased urinary excretion, leading to Cr mobilization that was not desirable to overcome the hyperglycemia. Copyright © 2017 Elsevier GmbH. All rights reserved.

Characterization of the hypothermic effects of imidazoline I2 receptor agonists in rats

PubMed Central

Thorn, David A; An, Xiao-Fei; Zhang, Yanan; Pigini, Maria; Li, Jun-Xu

2012-01-01

BACKGROUND AND PURPOSE Imidazoline I2 receptors have been implicated in several CNS disorders. Although several I2 receptor agonists have been described, no simple and sensitive in vivo bioassay is available for studying I2 receptor ligands. This study examined I2 receptor agonist-induced hypothermia as a functional in vivo assay of I2 receptor agonism. EXPERIMENTAL APPROACH Different groups of rats were used to examine the effects of I2 receptor agonists on the rectal temperature and locomotion. The pharmacological mechanisms were investigated by combining I2 receptor ligands and different antagonists. KEY RESULTS All the selective I2 receptor agonists examined (2-BFI, diphenyzoline, phenyzoline, CR4056, tracizoline, BU224 and S22687, 3.2–56 mg·kg–1, i.p.) dose-dependently and markedly decreased the rectal temperature (hypothermia) in rats, with varied duration of action. Pharmacological mechanism of the observed hypothermia was studied by combining the I2 receptor agonists (2-BFI, BU224, tracizoline and diphenyzoline) with imidazoline I2 receptor/ α2 adrenoceptor antagonist idazoxan, selective I1 receptor antagonist efaroxan, α2 adrenoceptor antagonist/5-HT1A receptor agonist yohimbine. Idazoxan but not yohimbine or efaroxan attenuated the hypothermic effects of 2-BFI, BU224, tracizoline and diphenyzoline, supporting the I2 receptor mechanism. In contrast, both idazoxan and yohimbine attenuated hypothermia induced by the α2 adrenoceptor agonist clonidine. Among all the I2 receptor agonists studied, only S22687 markedly increased the locomotor activity in rats. CONCLUSIONS AND IMPLICATIONS Imidazoline I2 receptor agonists can produce hypothermic effects, which are primarily mediated by I2 receptors. These data suggest that I2 receptor agonist-induced hypothermia is a simple and sensitive in vivo assay for studying I2 receptor ligands. PMID:22324428

Gonadotropin-Releasing Hormone Agonist Combined With a Levonorgestrel-Releasing Intrauterine System or Letrozole for Fertility-Preserving Treatment of Endometrial Carcinoma and Complex Atypical Hyperplasia in Young Women.

PubMed

Zhou, Huimei; Cao, Dongyan; Yang, Jiaxin; Shen, Keng; Lang, Jinghe

2017-07-01

The aim of this study was to evaluate the efficacy and safety with gonadotropin-releasing hormone agonist (GnRHa) combined with a levonorgestrel-releasing intrauterine system or an aromatase inhibitor (letrozole) in young women with well-differentiated early endometrial carcinoma (EC) and complex atypical hyperplasia (CAH). We performed a retrospective analysis including the clinical characteristics of 29 patients younger than 45 years with early well-differentiated endometrioid adenocarcinoma of the uterus (EC) or CAH who were treated at the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, from January 2012 to April 2016. Eighteen patients were treated with the combination of intramuscular injections of GnRHa every 4 weeks with the levonorgestrel intrauterine hormonal system (Mirena® Bayer Health Care Pharmaceutical Inc, Wayne, NY) was inserted. Eleven patients were treated with the combination of intramuscular injections of GnRHa every 4 weeks with oral letrozole 2.5 mg daily. The patients underwent follow-up with endometrial sampling by hysteroscopy and curettage for endometrial response every 3 months. After a median follow-up of 18.7 months (range, 5.6-54.9 months), 15 women (88.2%) in the EC group and 12 women (100%) in the CAH group had complete response (CR) after GnRHa combination treatment. Among the women who achieved CR, 1 woman (8.3%) with CAH and 1 woman (5.9%) with EC had recurrence after CR, and they finally underwent a hysterectomy. Time to CR was similar in the 2 groups (4.5 ± 1.9 months in the CAH group vs 5.0 ± 2.9 months in the EC group). Ten women (34.5%) had CR after the first 3 months, 8 women (27.6%) had CR after 6 months, and 9 women (31.0%) had CR after 9 months. Both GnRHa with the levonorgestrel-releasing intrauterine system and GnRHa with letrozole are alternative treatments for women with CAH and EC who desire fertility preservation. A larger multicenter trial of the fertility-preserving treatment is warranted.

Accumulation of heavy metals in soil-crop systems: a review for wheat and corn.

PubMed

Wang, Shiyu; Wu, Wenyong; Liu, Fei; Liao, Renkuan; Hu, Yaqi

2017-06-01

The health risks arising from heavy metal pollution (HMP) in agricultural soils have attracted global attention, and research on the accumulation of heavy metals in soil-plant systems is the basis for human health risk assessments. This review studied the accumulation of seven typical heavy metals-Cd, Cr, As, Pb, Hg, Cu, and Zn-in soil-corn and soil-wheat systems. The findings indicated that, in general, wheat was more likely to accumulate heavy metals than corn. Bioconcentration factor (BCF) of the seven heavy metals in wheat and corn grains decreased exponentially with their average concentrations in soil. The seven heavy metals were ranked as follows, in ascending order of accumulation in corn grains: Pb < Cr < Zn < As < Cu < Cd

Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia.

PubMed

Newman-Tancredi, Adrian; Assié, Marie-Bernadette; Leduc, Nathalie; Ormière, Anne-Marie; Danty, Nathalie; Cosi, Cristina

2005-09-01

Serotonin 5-HT1A receptors are promising targets in the management of schizophrenia but little information exists about affinity and efficacy of novel antipsychotics at these sites. We addressed this issue by comparing binding affinity at 5-HT1A receptors with dopamine rD2 receptors, which are important targets for antipsychotic drug action. Agonist efficacy at 5-HT1A receptors was determined for G-protein activation and adenylyl cyclase activity. Whereas haloperidol, thioridazine, risperidone and olanzapine did not interact with 5-HT1A receptors, other antipsychotic agents exhibited agonist properties at these sites. E(max) values (% effect induced by 10 microM of 5-HT) for G-protein activation at rat brain 5-HT1A receptors: sarizotan (66.5), bifeprunox (35.9), SSR181507 (25.8), nemonapride (25.7), ziprasidone (20.6), SLV313 (19), aripiprazole (15), tiospirone (8.9). These data were highly correlated with results obtained at recombinant human 5-HT1A receptors in determinations of G-protein activation and inhibition of forskolin-stimulated adenylyl cyclase. In binding-affinity determinations, the antipsychotics exhibited diverse properties at r5-HT1A receptors: sarizotan (pK(i)=8.65), SLV313 (8.64), SSR181507 (8.53), nemonapride (8.35), ziprasidone (8.30), tiospirone (8.22), aripiprazole (7.42), bifeprunox (7.19) and clozapine (6.31). The affinity ratios of the ligands at 5-HT1A vs. D2 receptors also varied widely: ziprasidone, SSR181507 and SLV313 had similar affinities whereas aripiprazole, nemonapride and bifeprunox were more potent at D2 than 5-HT1A receptors. Taken together, these data indicate that aripiprazole has low efficacy and modest affinity at 5-HT1A receptors, whereas bifeprunox has low affinity but high efficacy. In contrast, SSR181507 has intermediate efficacy but high affinity, and is likely to have more prominent 5-HT1A receptor agonist properties. Thus, the contribution of 5-HT1A receptor activation to the pharmacological profile of action of the antipsychotics will depend on the relative 5-HT1A/D2 affinities and on 5-HT1A agonist efficacy of the drugs.

Radially polarized and passively Q-switched Yb-doped fiber laser based on intracavity birefringent mode discrimination

NASA Astrophysics Data System (ADS)

Sun, Xuehuan; Wu, Yongxiao; Chen, Sanbin; Li, Jianlang

2018-05-01

In this paper, we demonstrated a passive Q-switched ytterbium-doped fiber laser with radially polarized beam emission by using a c-cut YVO4 birefringent crystal as the intracavity polarization discriminator, and a Cr4+:YAG crystal as the saturable absorber and output coupler. The maximum averaged laser power reached 3.89 W with a high slope efficiency of 66.5%. The laser pulse had a peak power of 161 W, 160 ns duration, and 151 kHz repetition rate at the absorbed pump power of 6.48 W. Such a radially polarized pulse would facilitate numerous applications.

Effects of chromium(III) picolinate on cortisol and DHEAs secretion in H295R human adrenocortical cells.

PubMed

Kim, Beob G; Adams, Julye M; Jackson, Brian A; Lindemann, Merlin D

2010-02-01

Dietary chromium(III) picolinate (CrPic) effects on circulating steroid hormones have been reported in various experimental animals. However, direct effects of CrPic on adrenocortical steroidogenesis are uncertain. Therefore, the objective was to determine the effects of CrPic on cortisol and dehydroepiandrosterone sulfate (DHEAs) secretion from H295R cells. In experiment 1, a 24-h exposure to CrPic (0 to 200 microM) had both linear (p < 0.001) and quadratic (p < 0.001) effects on cortisol secretion from forskolin-stimulated cells with the highest cortisol secretion at 0.1 microM of CrPic and the lowest at 200 microM of CrPic. In experiment 2, a 48-h exposure to CrPic (200 microM) decreased cortisol (p < 0.07) release from forskolin-stimulated cells during a 24-h collection period. In experiment 3, a 48-h exposure to CrPic (100 microM) decreased cortisol (p < 0.05) and DHEAs (p < 0.01) from forskolin-stimulated cells during a 24-h sampling period. In experiment 4, a 24-h exposure to forskolin followed by a 24-h exposure to both forskolin and CrPic (100 and 200 microM) decreased both cortisol and DHEAs secretion (p < 0.01). This study suggests that at high concentrations, CrPic inhibits aspects of steroidogenesis in agonist-stimulated adrenocortical cells.

50 CFR 665.105 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.105 Section 665.105 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.105 At-sea observer coverage. All fishing vessels subject to §§ 665.100 through 665.105 must carry...

50 CFR 665.606 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.606 Section 665.606 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.606 At-sea observer coverage. All fishing vessels subject to §§ 665.600 through 665.606 must...

50 CFR 665.606 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.606 Section 665.606 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.606 At-sea observer coverage. All fishing vessels subject to §§ 665.600 through 665.606 must...

50 CFR 665.645 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.645 Section 665.645 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.645 At-sea observer coverage. All fishing vessels subject to §§ 665.640 through 665.645 and...

50 CFR 665.645 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.645 Section 665.645 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.645 At-sea observer coverage. All fishing vessels subject to §§ 665.640 through 665.645 and...

50 CFR 665.105 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.105 Section 665.105 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.105 At-sea observer coverage. All fishing vessels subject to §§ 665.100 through 665.105 must carry...

50 CFR 665.145 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

50 CFR 665.645 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.645 Section 665.645 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.645 At-sea observer coverage. All fishing vessels subject to §§ 665.640 through 665.645 and...

50 CFR 665.445 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.445 Section 665.445 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.445 At-sea observer coverage. All fishing vessels subject to §§ 665.440 through 665.445 and...

50 CFR 665.407 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.407 Section 665.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.407 At-sea observer coverage. All fishing vessels subject to §§ 665.400 through 665.407 must carry...

50 CFR 665.606 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.606 Section 665.606 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.606 At-sea observer coverage. All fishing vessels subject to §§ 665.600 through 665.606 must...

50 CFR 665.645 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.645 Section 665.645 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.645 At-sea observer coverage. All fishing vessels subject to §§ 665.640 through 665.645 and...

50 CFR 665.105 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.105 Section 665.105 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.105 At-sea observer coverage. All fishing vessels subject to §§ 665.100 through 665.105 must carry...

50 CFR 665.145 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

50 CFR 665.606 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.606 Section 665.606 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.606 At-sea observer coverage. All fishing vessels subject to §§ 665.600 through 665.606 must...

50 CFR 665.445 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.445 Section 665.445 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.445 At-sea observer coverage. All fishing vessels subject to §§ 665.440 through 665.445 and...

50 CFR 665.145 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

50 CFR 665.445 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.445 Section 665.445 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.445 At-sea observer coverage. All fishing vessels subject to §§ 665.440 through 665.445 and...

50 CFR 665.145 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

50 CFR 665.407 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.407 Section 665.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.407 At-sea observer coverage. All fishing vessels subject to §§ 665.400 through 665.407 must carry...

50 CFR 665.407 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.407 Section 665.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.407 At-sea observer coverage. All fishing vessels subject to §§ 665.400 through 665.407 must carry...

50 CFR 665.445 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.445 Section 665.445 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.445 At-sea observer coverage. All fishing vessels subject to §§ 665.440 through 665.445 and...

50 CFR 665.645 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.645 Section 665.645 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.645 At-sea observer coverage. All fishing vessels subject to §§ 665.640 through 665.645 and...

50 CFR 665.445 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.445 Section 665.445 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.445 At-sea observer coverage. All fishing vessels subject to §§ 665.440 through 665.445 and...

50 CFR 665.407 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.407 Section 665.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.407 At-sea observer coverage. All fishing vessels subject to §§ 665.400 through 665.407 must carry...

50 CFR 665.145 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

50 CFR 665.606 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.606 Section 665.606 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 665.606 At-sea observer coverage. All fishing vessels subject to §§ 665.600 through 665.606 must...

50 CFR 665.407 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.407 Section 665.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.407 At-sea observer coverage. All fishing vessels subject to §§ 665.400 through 665.407 must carry...

50 CFR 665.105 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.105 Section 665.105 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.105 At-sea observer coverage. All fishing vessels subject to §§ 665.100 through 665.105 must carry...

50 CFR 665.105 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.105 Section 665.105 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.105 At-sea observer coverage. All fishing vessels subject to §§ 665.100 through 665.105 must carry...

The Role of 5-HT2A, 5-HT2C and mGlu2 Receptors in the Behavioral Effects of Tryptamine Hallucinogens N,N-Dimethyltryptamine and N,N-Diisopropyltryptamine in Rats and Mice

PubMed Central

Carbonaro, Theresa M.; Eshleman, Amy J.; Forster, Michael J.; Cheng, Kejun; Rice, Kenner C.; Gatch, Michael B.

2014-01-01

Rationale: Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. Objective: The present study assesses the role of these 5-HT and glutamate receptors as molecular targets for two tryptamine hallucinogens, N,N-dimethyltryptamine (DMT) and N,N-diisopropyltryptamine (DiPT). Methods: Drug discrimination, head twitch and radioligand binding assays were used. A 5-HT2AR inverse agonist (MDL100907), 5-HT2CR antagonist (SB242084) and mGluR2/3 agonist (LY379268) were tested for their ability to attenuate the discriminative stimulus effects of DMT and DiPT; an mGluR2/3 antagonist (LY341495) was tested for potentiation. MDL100907 was used to attenuate head twitches induced by DMT and DiPT. Radioligand binding studies and inosital-1-phosphate (IP-1) accumulation were performed at the 5-HT2CR for DiPT. Results: MDL100907 fully blocked the discriminative stimulus effects of DMT, but only partially blocked DiPT. SB242084 partially attenuated the discriminative stimulus effects of DiPT, but produced minimal attenuation of DMT’s effects. LY379268 produced potent, but only partial blockade of the discriminative stimulus effects of DMT. LY341495 facilitated DMT- and DiPT-like effects. Both compounds elicited head twitches (DiPT>DMT) which were blocked by MDL1000907. DiPT was a low potency full agonist at 5-HT2CR in vitro. Conclusions: The 5-HT2AR likely plays a major role in mediating the effects of both compounds. 5-HT2C and mGluR2 receptors likely modulate the discriminative stimulus effects of both compounds to some degree. PMID:24985890

The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.

PubMed

Carbonaro, Theresa M; Eshleman, Amy J; Forster, Michael J; Cheng, Kejun; Rice, Kenner C; Gatch, Michael B

2015-01-01

Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. The present study assesses the role of these 5-HT and glutamate receptors as molecular targets for two tryptamine hallucinogens, N,N-dimethyltryptamine (DMT) and N,N-diisopropyltryptamine (DiPT). Drug discrimination, head twitch, and radioligand binding assays were used. A 5-HT2AR inverse agonist (MDL100907), 5-HT2CR antagonist (SB242084), and mGluR2/3 agonist (LY379268) were tested for their ability to attenuate the discriminative stimulus effects of DMT and DiPT; an mGluR2/3 antagonist (LY341495) was tested for potentiation. MDL100907 was used to attenuate head twitches induced by DMT and DiPT. Radioligand binding studies and inosital-1-phosphate (IP-1) accumulation were performed at the 5-HT2CR for DiPT. MDL100907 fully blocked the discriminative stimulus effects of DMT, but only partially blocked DiPT. SB242084 partially attenuated the discriminative stimulus effects of DiPT, but produced minimal attenuation of DMT's effects. LY379268 produced potent, but only partial blockade of the discriminative stimulus effects of DMT. LY341495 facilitated DMT- and DiPT-like effects. Both compounds elicited head twitches (DiPT>DMT) which were blocked by MDL1000907. DiPT was a low-potency full agonist at 5-HT2CR in vitro. The 5-HT2AR likely plays a major role in mediating the effects of both compounds. 5-HT2C and mGluR2 receptors likely modulate the discriminative stimulus effects of both compounds to some degree.

Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.

PubMed

Phillips, Benjamin U; Dewan, Sigma; Nilsson, Simon R O; Robbins, Trevor W; Heath, Christopher J; Saksida, Lisa M; Bussey, Timothy J; Alsiö, Johan

2018-04-22

Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback. However, the precise mechanism through which 5-HT tone biases feedback responsivity remains unclear. 5-HT2C receptors (5-HT2CRs) are closely linked with aspects of depressive symptomatology, including abnormalities in reinforcement processes and response to stress. Thus, we aimed to determine the impact of 5-HT2CR function on response to feedback in biased reinforcement learning. We used two touchscreen assays designed to assess the impact of positive and negative feedback on probabilistic reinforcement in mice, including a novel valence-probe visual discrimination (VPVD) and a probabilistic reversal learning procedure (PRL). Systemic administration of a 5-HT2CR agonist and antagonist resulted in selective changes in the balance of feedback sensitivity bias on these tasks. Specifically, on VPVD, SB 242084, the 5-HT2CR antagonist, impaired acquisition of a discrimination dependent on appropriate integration of positive and negative feedback. On PRL, SB 242084 at 1 mg/kg resulted in changes in behaviour consistent with reduced sensitivity to positive feedback. In contrast, WAY 163909, the 5-HT2CR agonist, resulted in changes associated with increased sensitivity to positive feedback and decreased sensitivity to negative feedback. These results suggest that 5-HT2CRs tightly regulate feedback sensitivity bias in mice with consequent effects on learning and cognitive flexibility and specify a framework for the influence of 5-HT2CRs on sensitivity to reinforcement.

50 CFR 665.207 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.207 Section 665.207 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. (a) All fishing vessels subject to §§ 665.200 though 665.212 must carry an...

50 CFR 665.207 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.207 Section 665.207 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. (a) All fishing vessels subject to §§ 665.200 though 665.212 must carry an...

50 CFR 665.207 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.207 Section 665.207 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. (a) All fishing vessels subject to §§ 665.200 though 665.212 must carry an...

50 CFR 665.207 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.207 Section 665.207 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. (a) All fishing vessels subject to §§ 665.200 though 665.212 must carry an...

50 CFR 665.207 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.207 Section 665.207 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. (a) All fishing vessels subject to §§ 665.200 though 665.212 must carry an...

Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife

PubMed Central

Hirasaki, Shoji; Kanzaki, Hiromitsu; Matsubara, Minoru; Fujita, Kohei; Ikeda, Fusao; Taniguchi, Hideaki; Yumoto, Eiichiro; Suzuki, Seiyuu

2007-01-01

AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with over 20 mm early gastric cancer (EGC). METHODS: A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group (21-40 mm)] and the remaining patients (under 20 mm group). RESULTS: We found no significant difference in the rate of underlying cardiopulmonary disease (over 20 mm group vs under 20 mm group, 5.0% vs 5.6%), one-piece resection rate (95% vs 96%), CR rate (85% vs 89%), operation time (72.3 min vs 66.5 min), bleeding rate (5% vs 4.2%), and perforation rate (0% vs 1.4%) between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION: There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future. PMID:17663514

50 CFR 665.247 - At-sea observer coverage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

50 CFR 665.247 - At-sea observer coverage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

50 CFR 665.247 - At-sea observer coverage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

50 CFR 665.247 - At-sea observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

50 CFR 665.247 - At-sea observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

50 CFR 665.243 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Fish for, take, or retain lobsters— (i) Without a limited access permit issued under § 665.242. (ii) By methods other than lobster traps or by hand for lobsters, as specified in § 665.245. (iii) From closed areas for lobsters, as specified in § 665.251. (iv) During a closed season, as specified in § 665.250...

50 CFR 665.243 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Fish for, take, or retain lobsters— (i) Without a limited access permit issued under § 665.242. (ii) By methods other than lobster traps or by hand for lobsters, as specified in § 665.245. (iii) From closed areas for lobsters, as specified in § 665.251. (iv) During a closed season, as specified in § 665.250...

50 CFR 665.601 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... § 665.601 Definitions. As used in §§ 665.600 through 665.619: PRIA bottomfish fishing permit means the... bass Epinephelus quernus. Red snapper Etelis carbunculus. Longtail snapper Etelis coruscans. Redgill...

50 CFR 665.601 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 665.601 Definitions. As used in §§ 665.600 through 665.619: PRIA bottomfish fishing permit means the... bass Epinephelus quernus. Red snapper Etelis carbunculus. Longtail snapper Etelis coruscans. Redgill...

50 CFR 665.601 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... § 665.601 Definitions. As used in §§ 665.600 through 665.619: PRIA bottomfish fishing permit means the... bass Epinephelus quernus. Red snapper Etelis carbunculus. Longtail snapper Etelis coruscans. Redgill...

50 CFR 665.601 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 665.601 Definitions. As used in §§ 665.600 through 665.619: PRIA bottomfish fishing permit means the... bass Epinephelus quernus. Red snapper Etelis carbunculus. Longtail snapper Etelis coruscans. Redgill...

50 CFR 665.601 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... § 665.601 Definitions. As used in §§ 665.600 through 665.619: PRIA bottomfish fishing permit means the... bass Epinephelus quernus. Red snapper Etelis carbunculus. Longtail snapper Etelis coruscans. Redgill...

Aripiprazole added to Overweight and Obese Olanzapine-treated Schizophrenia Patients

PubMed Central

Henderson, David C.; Fan, Xiaoduo; Copeland, Paul M.; Sharma, Bikash; Borba, Christina P; Boxill, Ryan; Freudenreich, Oliver; Cather, Corey; Evins, A. Eden; Goff, Donald C.

2015-01-01

Olanzapine treatment has been associated with clinically meaningful weight increases, hypertriglyceridemia, insulin resistance and diabetes mellitus. There are few options for olanzapine-responders who fail other antipsychotic agents. Aripiprazole is a potent (high-affinity) partial agonist at D2 and 5-HT1A receptors and a potent antagonist at 5-HT2A receptor and is associated with less weight gain than olanzapine. We report the results of a 10-week placebo controlled, double-blind crossover study that examined 15 mg/day aripiprazole's effects upon weight, lipids, glucose metabolism, and psychopathology in overweight and obese schizophrenia and schizoaffective disorder subjects treated with a stable dose of olanzapine. During the 4 weeks of aripiprazole treatment there were significant decreases in weight (p = .003) and BMI (p = .004) compared to placebo. Total serum cholesterol (p = .208), HDL-cholesterol (p = .99), HDL-2 (p=.08), HDL-3 (p=.495) and LDL- cholesterol (p=.665) did not change significantly comparing aripiprazole treatment to placebo treatment. However, total serum triglycerides (p = .001), total VLDL-cholesterol (p=.01), VLDL 1- &2-cholesterol (p=.012) decreased significantly during the aripiprazole treatment phase. VLDL-3-cholesterol tended lower during aripiprazole, but the decrease was not significant (p=.062). There was a decrease in c-reactive protein comparing aripiprazole treatment to placebo though it did not reach significance (p=.087). The addition of aripiprazole to a stable dose of olanzapine was well tolerated and resulted in significant improvements on several outcome measures that predict risk for medical morbidity. PMID:19512978

50 CFR 665.240 - Hawaii crustacean fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Hawaii crustacean fisheries. [Reserved] 665.240 Section 665.240 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.240 Hawaii crustacean fisheries. [Reserved] ...

50 CFR 665.240 - Hawaii crustacean fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Hawaii crustacean fisheries. [Reserved] 665.240 Section 665.240 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.240 Hawaii crustacean fisheries. [Reserved] ...

50 CFR 665.240 - Hawaii crustacean fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Hawaii crustacean fisheries. [Reserved] 665.240 Section 665.240 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.240 Hawaii crustacean fisheries. [Reserved] ...

50 CFR 665.240 - Hawaii crustacean fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii crustacean fisheries. [Reserved] 665.240 Section 665.240 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.240 Hawaii crustacean fisheries. [Reserved] ...

50 CFR 665.440 - Mariana crustacean fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Mariana crustacean fisheries. [Reserved] 665.440 Section 665.440 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Mariana Archipelago Fisheries § 665.440 Mariana crustacean fisheries. [Reserved] ...

50 CFR 665.440 - Mariana crustacean fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Mariana crustacean fisheries. [Reserved] 665.440 Section 665.440 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Mariana Archipelago Fisheries § 665.440 Mariana crustacean fisheries. [Reserved] ...

50 CFR 665.440 - Mariana crustacean fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Mariana crustacean fisheries. [Reserved] 665.440 Section 665.440 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Mariana Archipelago Fisheries § 665.440 Mariana crustacean fisheries. [Reserved] ...

50 CFR 665.640 - PRIA crustacean fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false PRIA crustacean fisheries. [Reserved] 665.640 Section 665.640 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Island Area Fisheries § 665.640 PRIA crustacean fisheries. [Reserved] ...

50 CFR 665.640 - PRIA crustacean fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false PRIA crustacean fisheries. [Reserved] 665.640 Section 665.640 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Island Area Fisheries § 665.640 PRIA crustacean fisheries. [Reserved] ...

50 CFR 665.640 - PRIA crustacean fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false PRIA crustacean fisheries. [Reserved] 665.640 Section 665.640 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Island Area Fisheries § 665.640 PRIA crustacean fisheries. [Reserved] ...

Pancreatic stellate cells and CX3CR1: occurrence in normal pancreas and acute and chronic pancreatitis and effect of their activation by a CX3CR1 agonist.

PubMed

Uchida, Masahiko; Ito, Tetsuhide; Nakamura, Taichi; Hijioka, Masayuki; Igarashi, Hisato; Oono, Takamasa; Kato, Masaki; Nakamura, Kazuhiko; Suzuki, Koichi; Takayanagi, Ryoichi; Jensen, Robert T

2014-07-01

Numerous studies suggest important roles of the chemokine, fractalkine (CX3CL1), in acute/chronic pancreatitis; however, the possible mechanisms of the effects are unclear. Pancreatic stellate cells (PSCs) can play important roles in pancreatitis, secreting inflammatory cytokines/chemokines, as well as proliferation. Therefore, we investigated CX3CL1 receptor (CX3CR1) occurrence in normal pancreas and pancreatitis (acute/chronic) tissues and the effects of CX3CL1 on activated PSCs. CX3CR1 expression/localization in normal pancreas and pancreatitis (acute/chronic) tissues was evaluated with immunohistochemical analysis. CX3CR1 expression and effects of CX3CL1 on activated PSCs were examined with real-time polymerase chain reaction, BrdU (5-bromo-2-deoxyuridine) assays, and Western blotting. In normal pancreas, acinar cells expressed CX3CR1 within granule-like formations in the cytoplasm, whereas in acute/chronic pancreatitis, acinar, ductal, and activated PSCs expressed CX3CR1 on cell membranes. With activation of normal PSCs, CX3CR1 is increased. CX3CL1 activated multiple signaling cascades in PSCs. CX3CL1 did not induce inflammatory genes expression in activated PSCs, but induced proliferation. CX3CR1s are expressed in normal pancreas. Expression is increased in acute/chronic pancreatitis, and the CX3CR1s are activated. CX3CL1 induces proliferation of activated PSCs without increasing release of inflammatory mediators. These results suggest that CX3CR1 activation of PSCs could be important in their effects in pancreatitis, especially to PSC proliferation in pancreatitis where CX3CL1 levels are elevated.

Pancreatic stellate cells and CX3CR1: occurrence in normal pancreas, acute and chronic pancreatitis and effect of their activation by a CX3CR1 agonist

PubMed Central

Uchida, Masahiko; Ito, Tetsuhide; Nakamura, Taichi; Hijioka, Masayuki; Igarashi, Hisato; Oono, Takamasa; Kato, Masaki; Nakamura, Kazuhiko; Suzuki, Koichi; Takayanagi, Ryoichi; Jensen, Robert T.

2014-01-01

Objectives Numerous studies suggest important roles of the chemokine, fractalkine (CX3CL1) in acute/chronic pancreatitis, however the possible mechanisms of the effects are unclear. Pancreatic stellate cells (PSCs) can play important roles in pancreatitis, secreting inflammatory cytokines/chemokines, as well as proliferation. Therefore, we investigated CX3CL1 receptor (CX3CR1) occurrence in normal pancreas and pancreatitis (acute/chronic) tissues, and the effects of CX3CL1 on activated-PSCs. Methods CX3CR1 expression/localization in normal pancreas and pancreatitis (acute/chronic) tissues were evaluated with immunohistochemical analysis. CX3CR1 expression and effects of CX3CL1 on activated-PSCs were examined with realtime-PCR, BrdU assays and Western Blotting. Results In normal pancreas, acinar cells expressed CX3CR1 within granule-like-formations in the cytoplasm, whereas in acute/chronic pancreatitis, acinar, ductal and activated-PSCs expressed CX3CR1 on cell membranes. With activation of normal PSCs, CX3CR1 is increased. CX3CL1 activated multiple signaling cascades in PSCs. CX3CL1, did not induce inflammatory-genes expression in activated-PSCs, but induced proliferation. Conclusions CX3CR1s are expressed in normal pancreas. Expression is increased in acute/chronic pancreatitis and the CX3CR1s are activated. CX3CL1 induces proliferation of activated-PSCs without increasing release of inflammatory-mediators. These results suggest that CX3CR1 activation of PSCs could be important in their effects in pancreatitis, especially to PSCs proliferation in pancreatitis where CX3CL1 levels are elevated. PMID:24681877

Trivalent chromium alleviates oleic acid induced steatosis in SMMC-7721 cells by decreasing fatty acid uptake and triglyceride synthesis.

PubMed

Wang, Song; Wang, Jian; Zhang, Xiaonan; Hu, Linlin; Fang, Zhijia; Huang, Zhiwei; Shi, Ping

2016-10-01

Trivalent chromium [Cr(III)] has been shown as an essential trace element for human health. Previous studies depict that Cr(III) plays important roles in maintaining normal glucose and lipid metabolism, whereas its effect on the hepatic lipid metabolism is still unknown. In the present study, we investigated the effects and underlying mechanisms of Cr on hepatic steatosis induced by oleic acid (OA) in human hepatoma SMMC-7721 cells. Hepatic steatosis model was co-administered with Cr. Indexes of lipid accumulation were determined and associated genes expression were analyzed. The data showed that OA could induce lipid accumulation and triglyceride (TG) content in SMMC-7721 cells, and significantly increase the expression of cluster of differentiation 36 (CD36) and diacylglycerol acyltransferase 2 (DGAT2). This steatosis effect of OA was ameliorated by Cr. The TG accumulation and up-regulation of CD36 and DGAT2 genes followed steatosis induction were inhibited by Cr. After the treatment of Cr, excessive intracellular OA content was also attenuated. Furthermore, Cr still performed inhibitory effect of DGAT2 expression at the presence of DGAT2 agonist or inhibitor, which indicated that the inhibitory effect of Cr on lipogenesis is associated with the downregulation of DGAT2 expression. These findings demonstrate that Cr alleviates hepatic steatosis via suppressing CD36 expression to prevent fatty acid uptake, as well as suppressing DGAT2 expression to inhibit TG synthesis. It suggests that CD36 and DGAT2 might become the novel drug targets for their properties in hepatic steatosis. Most importantly, Cr may be a potential anti-steatosis candidate to offer protective effects against liver damage.

7 CFR 3021.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false State. 3021.665 Section 3021.665 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 3021.665...

50 CFR 665.402 - Management subareas.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management subareas. 665.402 Section 665.402 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.402 Management subareas. The Mariana fishery management area is divided into bottomfish management...

50 CFR 665.402 - Management subareas.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management subareas. 665.402 Section 665.402 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.402 Management subareas. The Mariana fishery management area is divided into bottomfish management...

50 CFR 665.402 - Management subareas.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management subareas. 665.402 Section 665.402 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.402 Management subareas. The Mariana fishery management area is divided into bottomfish management...

50 CFR 665.402 - Management subareas.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management subareas. 665.402 Section 665.402 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.402 Management subareas. The Mariana fishery management area is divided into bottomfish management...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false American Samoa Crustacean Fisheries. [Reserved] 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.140 American Samoa Crustacean Fisheries. [Reserved] ...

50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false American Samoa Crustacean Fisheries. [Reserved] 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.140 American Samoa Crustacean Fisheries. [Reserved] ...

50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false American Samoa Crustacean Fisheries. [Reserved] 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.140 American Samoa Crustacean Fisheries. [Reserved] ...

50 CFR 665.460 - Mariana precious coral fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Mariana precious coral fisheries. [Reserved] 665.460 Section 665.460 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.460 Mariana precious coral fisheries. [Reserved] ...

50 CFR 665.260 - Hawaii precious coral fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Hawaii precious coral fisheries. [Reserved] 665.260 Section 665.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.260 Hawaii precious coral fisheries. [Reserved] ...

50 CFR 665.260 - Hawaii precious coral fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Hawaii precious coral fisheries. [Reserved] 665.260 Section 665.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.260 Hawaii precious coral fisheries. [Reserved] ...

50 CFR 665.460 - Mariana precious coral fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Mariana precious coral fisheries. [Reserved] 665.460 Section 665.460 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.460 Mariana precious coral fisheries. [Reserved] ...

50 CFR 665.260 - Hawaii precious coral fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Hawaii precious coral fisheries. [Reserved] 665.260 Section 665.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.260 Hawaii precious coral fisheries. [Reserved] ...

50 CFR 665.460 - Mariana precious coral fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Mariana precious coral fisheries. [Reserved] 665.460 Section 665.460 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.460 Mariana precious coral fisheries. [Reserved] ...

50 CFR 665.460 - Mariana precious coral fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Mariana precious coral fisheries. [Reserved] 665.460 Section 665.460 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.460 Mariana precious coral fisheries. [Reserved] ...

50 CFR 665.260 - Hawaii precious coral fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Hawaii precious coral fisheries. [Reserved] 665.260 Section 665.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.260 Hawaii precious coral fisheries. [Reserved] ...

50 CFR 665.460 - Mariana precious coral fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Mariana precious coral fisheries. [Reserved] 665.460 Section 665.460 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.460 Mariana precious coral fisheries. [Reserved] ...

50 CFR 665.260 - Hawaii precious coral fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii precious coral fisheries. [Reserved] 665.260 Section 665.260 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.260 Hawaii precious coral fisheries. [Reserved] ...

50 CFR 665.402 - Management subareas.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management subareas. 665.402 Section 665.402 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.402 Management subareas. The Mariana fishery management area is divided into bottomfish management...

50 CFR 665.220 - Hawaii coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Hawaii coral reef ecosystem fisheries. [Reserved] 665.220 Section 665.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.220 Hawaii coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.220 - Hawaii coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Hawaii coral reef ecosystem fisheries. [Reserved] 665.220 Section 665.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.220 Hawaii coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.220 - Hawaii coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Hawaii coral reef ecosystem fisheries. [Reserved] 665.220 Section 665.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.220 Hawaii coral reef ecosystem fisheries. [Reserved] ...

13 CFR 147.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false State. 147.665 Section 147.665 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Definitions § 147.665 State. State means any of the States of the United States...

50 CFR 665.220 - Hawaii coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii coral reef ecosystem fisheries. [Reserved] 665.220 Section 665.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.220 Hawaii coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.220 - Hawaii coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Hawaii coral reef ecosystem fisheries. [Reserved] 665.220 Section 665.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Hawaii Fisheries § 665.220 Hawaii coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.222 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.222 Section 665.222 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.222 Management...

50 CFR 665.222 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.222 Section 665.222 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.222 Management...

50 CFR 665.222 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.222 Section 665.222 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.222 Management...

50 CFR 665.198 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.198 Section 665.198 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.198 Management...

50 CFR 665.222 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.222 Section 665.222 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.222 Management...

50 CFR 665.198 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.198 Section 665.198 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.198 Management...

50 CFR 665.198 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.198 Section 665.198 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.198 Management...

50 CFR 665.198 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.198 Section 665.198 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.198 Management...

75 FR 2197 - Western Pacific Fisheries; Regulatory Restructuring

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-14

....16 Vessel identification. Sec. 665.17 Experimental fishing..... Sec. 665.17 Experimental fishing. Sec.... 0586, and -0589. Sec. 665.17 Experimental Sec. 665.17 0648-0214 and -0490. fishing. Experimental...) experimental fishing reports estimated at 4 hours (hr) per reporting action; (d) sales and transshipment...

46 CFR 154.665 - Welding procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Welding procedures. 154.665 Section 154.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Construction § 154.665 Welding procedures. Welding procedure tests for cargo tanks for a design temperature...

20 CFR 439.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false State. 439.665 Section 439.665 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 439.665 State. State means any of the States of the United States, the District of...

22 CFR 1008.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true State. 1008.665 Section 1008.665 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1008.665 State. State means any of the States of the United States, the District of...

22 CFR 1509.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true State. 1509.665 Section 1509.665 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.665 State. State means any of the States of the United States, the District of...

50 CFR 665.251 - Closed areas.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Closed areas. 665.251 Section 665.251 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.251 Closed areas...

50 CFR 665.660 - PRIA precious coral fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false PRIA precious coral fisheries. [Reserved] 665.660 Section 665.660 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Pacific Remote Island Area Fisheries § 665.660 PRIA precious coral fisheries. [Reserved] ...

50 CFR 665.660 - PRIA precious coral fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false PRIA precious coral fisheries. [Reserved] 665.660 Section 665.660 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Pacific Remote Island Area Fisheries § 665.660 PRIA precious coral fisheries. [Reserved] ...

50 CFR 665.660 - PRIA precious coral fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false PRIA precious coral fisheries. [Reserved] 665.660 Section 665.660 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Pacific Remote Island Area Fisheries § 665.660 PRIA precious coral fisheries. [Reserved] ...

50 CFR 665.660 - PRIA precious coral fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false PRIA precious coral fisheries. [Reserved] 665.660 Section 665.660 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Pacific Remote Island Area Fisheries § 665.660 PRIA precious coral fisheries. [Reserved] ...

50 CFR 665.660 - PRIA precious coral fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false PRIA precious coral fisheries. [Reserved] 665.660 Section 665.660 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Pacific Remote Island Area Fisheries § 665.660 PRIA precious coral fisheries. [Reserved] ...

41 CFR 105-74.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false State. 105-74.665 Section 105-74.665 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.665 State. State...

50 CFR 665.198 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.198 Section 665.198 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.198 Management...

50 CFR 665.222 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.222 Section 665.222 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.222 Management...

20 CFR 665.200 - What are required Statewide workforce investment activities?

Code of Federal Regulations, 2010 CFR

2010-04-01

... investment activities? 665.200 Section 665.200 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR STATEWIDE WORKFORCE INVESTMENT ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Required and Allowable Statewide Workforce Investment Activities § 665.200 What are required Statewide...

45 CFR 630.665 - State.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 630.665 Section 630.665 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.665 State. State means any of the States...

46 CFR 154.665 - Welding procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Welding procedures. 154.665 Section 154.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Construction § 154.665 Welding procedures. Welding procedure tests for cargo tanks for a design temperature...

46 CFR 154.665 - Welding procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Welding procedures. 154.665 Section 154.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Construction § 154.665 Welding procedures. Welding procedure tests for cargo tanks for a design temperature...

46 CFR 154.665 - Welding procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Welding procedures. 154.665 Section 154.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Construction § 154.665 Welding procedures. Welding procedure tests for cargo tanks for a design temperature...

46 CFR 154.665 - Welding procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Welding procedures. 154.665 Section 154.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS... Construction § 154.665 Welding procedures. Welding procedure tests for cargo tanks for a design temperature...

50 CFR 665.420 - Mariana coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Mariana coral reef ecosystem fisheries. [Reserved] 665.420 Section 665.420 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.420 Mariana coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.420 - Mariana coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Mariana coral reef ecosystem fisheries. [Reserved] 665.420 Section 665.420 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.420 Mariana coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.420 - Mariana coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Mariana coral reef ecosystem fisheries. [Reserved] 665.420 Section 665.420 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.420 Mariana coral reef ecosystem fisheries. [Reserved] ...

46 CFR 108.665 - Appliances for watertight integrity.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Appliances for watertight integrity. 108.665 Section 108.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Equipment Markings and Instructions § 108.665 Appliances for watertight integrity...

50 CFR 665.420 - Mariana coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Mariana coral reef ecosystem fisheries. [Reserved] 665.420 Section 665.420 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.420 Mariana coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.420 - Mariana coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Mariana coral reef ecosystem fisheries. [Reserved] 665.420 Section 665.420 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Mariana Archipelago Fisheries § 665.420 Mariana coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.263 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Prohibitions. 665.263 Section 665.263 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION.... In addition to the general prohibitions specified in 50 CFR 600.725 and in 665.15, it is unlawful for...

50 CFR 665.664 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.664 Section 665.664 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... § 665.664 Gear restrictions. Only selective gear may be used to harvest coral from any precious coral...

22 CFR 133.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false State. 133.665 Section 133.665 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 133.665 State. State means any of the States of the United States, the District of...

22 CFR 312.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true State. 312.665 Section 312.665 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.665 State. State means any of the States of the United States, the District of Columbia, the...

50 CFR 665.160 - American Samoa precious coral fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false American Samoa precious coral fisheries. [Reserved] 665.160 Section 665.160 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.160 American Samoa precious coral fisheries. [Reserved] ...

50 CFR 665.160 - American Samoa precious coral fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa precious coral fisheries. [Reserved] 665.160 Section 665.160 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.160 American Samoa precious coral fisheries. [Reserved] ...

50 CFR 665.160 - American Samoa precious coral fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false American Samoa precious coral fisheries. [Reserved] 665.160 Section 665.160 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.160 American Samoa precious coral fisheries. [Reserved] ...

50 CFR 665.160 - American Samoa precious coral fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false American Samoa precious coral fisheries. [Reserved] 665.160 Section 665.160 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.160 American Samoa precious coral fisheries. [Reserved] ...

50 CFR 665.160 - American Samoa precious coral fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false American Samoa precious coral fisheries. [Reserved] 665.160 Section 665.160 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC American Samoa Fisheries § 665.160 American Samoa precious coral fisheries. [Reserved] ...

50 CFR 665.209 - Fishing moratorium at Hancock Seamounts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Fishing moratorium at Hancock Seamounts. 665.209 Section 665.209 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.209 Fishing moratorium at Hancock Seamounts. Fishing for, and possession of...

50 CFR 665.209 - Fishing moratorium at Hancock Seamounts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Fishing moratorium at Hancock Seamounts. 665.209 Section 665.209 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.209 Fishing moratorium at Hancock Seamounts. Fishing for, and possession of...

50 CFR 665.209 - Fishing moratorium at Hancock Seamounts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Fishing moratorium at Hancock Seamounts. 665.209 Section 665.209 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.209 Fishing moratorium at Hancock Seamounts. Fishing for, and possession of...

50 CFR 665.209 - Fishing moratorium at Hancock Seamounts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Fishing moratorium at Hancock Seamounts. 665.209 Section 665.209 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.209 Fishing moratorium at Hancock Seamounts. Fishing for, and possession of...

50 CFR 665.209 - Fishing moratorium on Hancock Seamount.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Fishing moratorium on Hancock Seamount. 665.209 Section 665.209 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Hawaii Fisheries § 665.209 Fishing moratorium on Hancock Seamount. Fishing for Hawaii bottomfish and...

50 CFR 665.598 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.598 Section 665.598 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... § 665.598 Management area. The PRIA fishery management area is the EEZ seaward of Palmyra Atoll, Kingman...

28 CFR 66.5 - Effect on other issuances.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Effect on other issuances. 66.5 Section 66.5 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS General § 66.5 Effect on other...

Left ventricular mass, geometry and function in diabetic patients affected by coronary artery disease.

PubMed

Maiello, Maria; Zito, Annapaola; Carbonara, Santa; Ciccone, Marco Matteo; Palmiero, Pasquale

2017-10-01

Coronary artery disease (CAD) is quite common among diabetic patients, our study goal is to detect the prevalence of left ventricular (LV) adverse changes in geometry, mass and diastolic function on diabetic, but not hypertensive patients, with coronary artery disease(CAD) and LV ejection fraction(LVEF)>45%, actually unknown, because of current guidelines that do not include echocardiographic assessment for follow up of diabetic patients. 665 consecutive diabetic patients (443 females, mean age 66±9years), performed a complete echocardiographic assessment according to current ASE echo-guidelines: diastolic dysfunction (DD), eccentric hypertrophy (EH), concentric hypertrophy (CH) and concentric remodeling (CR) of LV were reported. CAD was assessed only by reports of bypass surgery, angioplasty or patients hospitalized for acute myocardial infarction. 218 patients (32.8%) presented LV changes: LVDD 49 (7.4%), LVEH 68 (10.2%), LVDD and EH 46 (6.9%), LVDD and CH 36 (5.4%), LVDD and CR 19 (2.9%). 447 (67.2%) had no LV changes. 81 (12.1%) patients with CAD, presented: LVDD 17 (21%), LVEH 32 (39.5%), LVDD and EH 9 (11.1%), LVDD and CH 7 (8.6%), LVDD and CR 8 (9.9%), 8 (9.9%) had no LV adverse changes. There were among CAD patients, a significantly higher prevalence of LVDD (p<0.02), LV eccentric hypertrophy (EH) (p<0.05), DD and LVEH (p<0.04), DD and LV concentric hypertrophy(CH) (p<0.03) and DD and LV concentric remodeling (p<0.02), when compared with those patients without CAD. CAD is related to all different patterns of LV adverse changes in mass, geometry and diastolic function, with a significantly higher prevalence in our population of diabetic patients with normal systolic function. These changes however remain unrecognized until they undergo to a conventional echocardiographic assessment. We support this tool need to be included into future guidelines concerning follow-up of diabetic patients. Copyright © 2017 Elsevier Inc. All rights reserved.

50 CFR 665.621 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 665.621 Definitions. As used in §§ 665.620 through 665.639: PRIA coral reef ecosystem management unit species (PRIA coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.120 - American Samoa coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false American Samoa coral reef ecosystem fisheries. [Reserved] 665.120 Section 665.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC American Samoa Fisheries § 665.120 American Samoa coral reef ecosystem fisheries...

50 CFR 665.621 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... § 665.621 Definitions. As used in §§ 665.620 through 665.639: PRIA coral reef ecosystem management unit species (PRIA coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.620 - PRIA coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false PRIA coral reef ecosystem fisheries. [Reserved] 665.620 Section 665.620 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Pacific Remote Island Area Fisheries § 665.620 PRIA coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.620 - PRIA coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false PRIA coral reef ecosystem fisheries. [Reserved] 665.620 Section 665.620 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Pacific Remote Island Area Fisheries § 665.620 PRIA coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.661 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 665.661 Definitions. As used in §§ 665.660 through 665.669: PRIA precious coral management unit species (PRIA precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Englishcommon name Scientific name Pink coral (also known as red coral) Corallium...

50 CFR 665.620 - PRIA coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false PRIA coral reef ecosystem fisheries. [Reserved] 665.620 Section 665.620 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Pacific Remote Island Area Fisheries § 665.620 PRIA coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.120 - American Samoa coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false American Samoa coral reef ecosystem fisheries. [Reserved] 665.120 Section 665.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC American Samoa Fisheries § 665.120 American Samoa coral reef ecosystem fisheries...

50 CFR 665.621 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... § 665.621 Definitions. As used in §§ 665.620 through 665.639: PRIA coral reef ecosystem management unit species (PRIA coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.661 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... § 665.661 Definitions. As used in §§ 665.660 through 665.669: PRIA precious coral management unit species (PRIA precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Englishcommon name Scientific name Pink coral (also known as red coral) Corallium...

50 CFR 665.661 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... § 665.661 Definitions. As used in §§ 665.660 through 665.669: PRIA precious coral management unit species (PRIA precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Englishcommon name Scientific name Pink coral (also known as red coral) Corallium...

50 CFR 665.120 - American Samoa coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false American Samoa coral reef ecosystem fisheries. [Reserved] 665.120 Section 665.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC American Samoa Fisheries § 665.120 American Samoa coral reef ecosystem fisheries...

50 CFR 665.123 - Relation to other laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Relation to other laws. 665.123 Section 665.123 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.123 Relation to other laws. To ensure consistency between the management regimes of different...

10 CFR 607.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false State. 607.665 Section 607.665 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.665 State. State means any of the States of the United States, the District of Columbia, the...

33 CFR 117.665 - Red River of the North.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Red River of the North. 117.665 Section 117.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Minnesota § 117.665 Red River of the North. The draws...

33 CFR 117.665 - Red River of the North.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Red River of the North. 117.665 Section 117.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Minnesota § 117.665 Red River of the North. The draws...

33 CFR 117.665 - Red River of the North.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Red River of the North. 117.665 Section 117.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Minnesota § 117.665 Red River of the North. The draws...

33 CFR 117.665 - Red River of the North.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Red River of the North. 117.665 Section 117.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Minnesota § 117.665 Red River of the North. The draws...

33 CFR 117.665 - Red River of the North.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Red River of the North. 117.665 Section 117.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Minnesota § 117.665 Red River of the North. The draws...

50 CFR 665.120 - American Samoa coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa coral reef ecosystem fisheries. [Reserved] 665.120 Section 665.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC American Samoa Fisheries § 665.120 American Samoa coral reef ecosystem fisheries...

50 CFR 665.620 - PRIA coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false PRIA coral reef ecosystem fisheries. [Reserved] 665.620 Section 665.620 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Pacific Remote Island Area Fisheries § 665.620 PRIA coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.661 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... § 665.661 Definitions. As used in §§ 665.660 through 665.669: PRIA precious coral management unit species (PRIA precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium...

50 CFR 665.620 - PRIA coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false PRIA coral reef ecosystem fisheries. [Reserved] 665.620 Section 665.620 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... PACIFIC Pacific Remote Island Area Fisheries § 665.620 PRIA coral reef ecosystem fisheries. [Reserved] ...

50 CFR 665.621 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... § 665.621 Definitions. As used in §§ 665.620 through 665.639: PRIA coral reef ecosystem management unit species (PRIA coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.120 - American Samoa coral reef ecosystem fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false American Samoa coral reef ecosystem fisheries. [Reserved] 665.120 Section 665.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC American Samoa Fisheries § 665.120 American Samoa coral reef ecosystem fisheries...

50 CFR 665.661 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 665.661 Definitions. As used in §§ 665.660 through 665.669: PRIA precious coral management unit species (PRIA precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium...

50 CFR 665.621 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 665.621 Definitions. As used in §§ 665.620 through 665.639: PRIA coral reef ecosystem management unit species (PRIA coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Transportation of vehicle. 665.25 Section 665.25..., DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall be responsible for transporting its vehicle to and from the bus testing facility at the beginning and...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Transportation of vehicle. 665.25 Section 665.25..., DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall be responsible for transporting its vehicle to and from the bus testing facility at the beginning and...

32 CFR 21.665 - Nonprocurement instrument.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Nonprocurement instrument. 21.665 Section 21.665 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal...

32 CFR 21.665 - Nonprocurement instrument.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Nonprocurement instrument. 21.665 Section 21.665 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal...

32 CFR 21.665 - Nonprocurement instrument.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Nonprocurement instrument. 21.665 Section 21.665 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal...

32 CFR 21.665 - Nonprocurement instrument.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Nonprocurement instrument. 21.665 Section 21.665 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal...

32 CFR 21.665 - Nonprocurement instrument.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Nonprocurement instrument. 21.665 Section 21.665 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal...

50 CFR 665.206 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.206 Section 665.206..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.206 Gear... MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a...

50 CFR 665.605 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.605 Section 665.605... § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a...

50 CFR 665.264 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.264 Section 665.264..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.264 Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area. ...

50 CFR 665.164 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.164 Section 665.164..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC American Samoa Fisheries § 665.164 Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area. ...

50 CFR 665.804 - Gear identification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear identification. 665.804 Section 665... Fisheries § 665.804 Gear identification. (a) Identification. The operator of each permitted vessel in the... action. Longline gear not marked in compliance with paragraph (a) of this section and found deployed in...

50 CFR 665.936 - International law.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false International law. 665.936 Section 665... National Monument § 665.936 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not...

50 CFR 665.936 - International law.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false International law. 665.936 Section 665... National Monument § 665.936 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not...

50 CFR 665.906 - International law.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false International law. 665.906 Section 665... National Monument § 665.906 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not...

50 CFR 665.906 - International law.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false International law. 665.906 Section 665... National Monument § 665.906 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not...

32 CFR 26.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false State. 26.665 Section 26.665 National Defense... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 26.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory...

29 CFR 1472.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false State. 1472.665 Section 1472.665 Labor Regulations Relating...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1472.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or...

24 CFR 21.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false State. 21.665 Section 21.665... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory...

40 CFR 36.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false State. 36.665 Section 36.665 Protection... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 36.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory...

22 CFR 210.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false State. 210.665 Section 210.665 Foreign... (FINANCIAL ASSISTANCE) Definitions § 210.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

29 CFR 94.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true State. 94.665 Section 94.665 Labor Office of the Secretary....665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

14 CFR 1267.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false State. 1267.665 Section 1267.665... WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1267.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the...

2 CFR 182.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false State. 182.665 Section 182.665 Grants and... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 182.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico...

15 CFR 29.665 - State.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false State. 29.665 Section 29.665 Commerce... WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 29.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the...

49 CFR 32.665 - State.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false State. 32.665 Section 32.665 Transportation Office... ASSISTANCE) Definitions § 32.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

45 CFR 1173.665 - State.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 1173.665 Section 1173.665 Public Welfare...) Definitions § 1173.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

31 CFR 20.665 - State.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false State. 20.665 Section 20.665 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.665 State. State means any of the States of the...

31 CFR 20.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false State. 20.665 Section 20.665 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.665 State. State means any of the States of the...

31 CFR 20.665 - State.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false State. 20.665 Section 20.665 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.665 State. State means any of the States of the...

31 CFR 20.665 - State.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false State. 20.665 Section 20.665 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.665 State. State means any of the States of the...

31 CFR 20.665 - State.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false State. 20.665 Section 20.665 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.665 State. State means any of the States of the...

21 CFR 1405.665 - State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false State. 1405.665 Section 1405.665 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1405.665 State. State means any of the States of the United States, the District of...

45 CFR 1155.665 - State.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 1155.665 Section 1155.665 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL...) Definitions § 1155.665 State. State means any of the States of the United States, the District of Columbia...

50 CFR 665.200 - Hawaii bottomfish and seamount groundfish fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii bottomfish and seamount groundfish fisheries. [Reserved] 665.200 Section 665.200 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... WESTERN PACIFIC Hawaii Fisheries § 665.200 Hawaii bottomfish and seamount groundfish fisheries. [Reserved] ...

49 CFR 665.23 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Fees. 665.23 Section 665.23 Transportation Other... TRANSPORTATION BUS TESTING Operations § 665.23 Fees. (a) The operator shall charge fees in accordance with a schedule approved by FTA, which shall include prorated fees for partial testing. (b) Fees shall be prorated...

49 CFR 665.13 - Test report and manufacturer certification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Test report and manufacturer certification. 665.13 Section 665.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Bus Testing Procedures § 665.13 Test report and manufacturer certification. (a) Upon...

46 CFR 169.665 - Name plates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Name plates. 169.665 Section 169.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and... Gross Tons § 169.665 Name plates. Each generator, motor and other major item f power equipment must be...

46 CFR 169.665 - Name plates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Name plates. 169.665 Section 169.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and... Gross Tons § 169.665 Name plates. Each generator, motor and other major item f power equipment must be...

46 CFR 169.665 - Name plates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Name plates. 169.665 Section 169.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and... Gross Tons § 169.665 Name plates. Each generator, motor and other major item f power equipment must be...

46 CFR 169.665 - Name plates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Name plates. 169.665 Section 169.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and... Gross Tons § 169.665 Name plates. Each generator, motor and other major item f power equipment must be...

46 CFR 169.665 - Name plates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Name plates. 169.665 Section 169.665 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and... Gross Tons § 169.665 Name plates. Each generator, motor and other major item f power equipment must be...

28 CFR 83.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false State. 83.665 Section 83.665 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 83.665 State. State means any of the States of the United States, the District of Columbia, the...

34 CFR 84.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false State. 84.665 Section 84.665 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.665 State. State means any of the States of the United States, the District of Columbia, the...

50 CFR 665.806 - Longline fishing prohibited area management.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Longline fishing prohibited area management. 665.806 Section 665.806 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Western Pacific Pelagic Fisheries § 665.806...

50 CFR 665.403 - Bottomfish fishery area management.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Bottomfish fishery area management. 665.403 Section 665.403 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries § 665.403 Bottomfish...

50 CFR 665.208 - Protected species conservation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Protected species conservation. 665.208... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of the protected species study zones defined in § 665.201 of this subpart: (a) If the Regional Administrator...

50 CFR 665.208 - Protected species conservation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Protected species conservation. 665.208... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of the protected species study zones defined in § 665.201 of this subpart: (a) If the Regional Administrator...

50 CFR 665.208 - Protected species conservation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Protected species conservation. 665.208... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of the protected species study zones defined in § 665.201 of this subpart: (a) If the Regional Administrator...

50 CFR 665.208 - Protected species conservation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Protected species conservation. 665.208... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of the protected species study zones defined in § 665.201 of this subpart: (a) If the Regional Administrator...

50 CFR 665.208 - Protected species conservation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Protected species conservation. 665.208... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of the protected species study zones defined in § 665.201 of this subpart: (a) If the Regional Administrator...

Type 2 diabetes mellitus treatment patterns in U.S. nursing home residents.

PubMed

Zarowitz, Barbara; Allen, Carrie; O'Shea, Terrence; Dalal, Mehul R; Haumschild, Mark; DiGenio, Andres

2015-06-01

The prevalence of type 2 diabetes mellitus (diabetes) in nursing home residents (NHRs) is increasing, concurrently with obesity and other comorbid conditions. NHR would benefit greatly from antidiabetic medications that would improve glycemic control and give a lower risk of hypoglycemia but that do not contribute to weight gain in obese individuals. To examine the prescription patterns to NHRs with diabetes, including the use of newer injectable therapies such as glucagon-like peptide-1 (GLP-1) receptor agonists. Treatment patterns of diabetes in NHR were analyzed using Minimum Data Set records and prescription claims from the Omnicare Senior Health Outcomes data repository (May 2011-September 2012). The prevalence of diabetes in this population of 229,283 NHRs was 35.4%. Among the 44,665 NHRs with diabetes and prescription claims data, the prevalence of obesity (40.3%) and multiple comorbidities (100%) was high. Approximately 20% of the NHRs with diabetes were aged <65 years. Overall, 20% of NHRs had diabetes that was untreated with medications during the study period. Insulin was the mainstay of treatment (>80%), followed by oral agents (54%). GLP-1 receptor agonist use was low (0.5%) and associated with poor treatment persistence. Considerations other than glycemic control may drive prescribing decisions, contrary to recommendations from the American Diabetes Association, American Medical Directors Association, and European Association for the Study of Diabetes.

50 CFR 665.966 - International law.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false International law. 665.966 Section 665... Monument § 665.966 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not a citizen, national...

50 CFR 665.966 - International law.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false International law. 665.966 Section 665... Monument § 665.966 International law. The regulations in this subpart shall be applied in accordance with international law. No restrictions shall apply to or be enforced against a person who is not a citizen, national...

43 CFR 43.665 - State.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false State. 43.665 Section 43.665 Public Lands... (FINANCIAL ASSISTANCE) Definitions § 43.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

50 CFR 665.817 - American Samoa pelagic fishery area management.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa pelagic fishery area management. 665.817 Section 665.817 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Western Pacific Pelagic Fisheries § 665.81...

MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms.

PubMed

Heair, Hannah M; Kemper, Austin G; Roy, Bhaskar; Lopes, Helena B; Rashid, Harunur; Clarke, John C; Afreen, Lubana K; Ferraz, Emanuela P; Kim, Eddy; Javed, Amjad; Beloti, Marcio M; MacDougall, Mary; Hassan, Mohammad Q

2015-09-01

Studies of proteins involved in microRNA (miRNA) processing, maturation, and silencing have indicated the importance of miRNAs in skeletogenesis, but the specific miRNAs involved in this process are incompletely defined. Here, we identified miRNA 665 (miR-665) as a potential repressor of odontoblast maturation. Studies with cultured cell lines and primary embryonic cells showed that miR-665 represses the expression of early and late odontoblast marker genes and stage-specific proteases involved in dentin maturation. Notably, miR-665 directly targeted Dlx3 mRNA and decreased Dlx3 expression. Furthermore, RNA-induced silencing complex (RISC) immunoprecipitation and biotin-labeled miR-665 pulldown studies identified Kat6a as another potential target of miR-665. KAT6A interacted physically and functionally with RUNX2, activating tissue-specific promoter activity and prompting odontoblast differentiation. Overexpression of miR-665 reduced the recruitment of KAT6A to Dspp and Dmp1 promoters and prevented KAT6A-induced chromatin remodeling, repressing gene transcription. Taken together, our results provide novel molecular evidence that miR-665 functions in an miRNA-epigenetic regulatory network to control dentinogenesis. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial.

PubMed

Kiefer, Falk; Kirsch, Martina; Bach, Patrick; Hoffmann, Sabine; Reinhard, Iris; Jorde, Anne; von der Goltz, Christoph; Spanagel, Rainer; Mann, Karl; Loeber, Sabine; Vollstädt-Klein, Sabine

2015-07-01

Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilitated by drugs increasing N-methyl-D-aspartate (NMDA) receptor-associated memory consolidation. In this study, we assessed the efficacy of CET treatment supplemented with the partial NMDA-receptor agonist D-cycloserine (DCS) at reducing mesolimbic cue reactivity (CR), craving, and relapse risk in alcoholism. In a randomized, placebo-controlled, double-blind study, we recruited 76 recently detoxified abstinent alcohol-dependent patients. Thirty-two (16 DCS, 16 placebo) patients showed cue-induced ventral-striatal activation measured with functional magnetic resonance imaging (fMRI) prior to treatment and were thus included in the efficacy analyses. After inpatient detoxification, patients underwent nine sessions of CET spaced over 3 weeks, receiving either 50 mg DCS or placebo 1 h prior to each CET session. FMRI was conducted before treatment and 3 weeks after treatment onset. Following treatment with CET plus DCS, cue-induced brain activation in the ventral and dorsal striatum was decreased compared to treatment with CET plus placebo. Elevated posttreatment ventral striatal CR and increased craving (assessed using the Obsessive Compulsive Drinking Scale) were associated with increased relapse risk. DCS was shown to augment the effect of CET for alcohol-dependent subjects. The interaction between craving and ventral-striatal CR on treatment outcome suggests that CET might be especially effective in patients exhibiting both high craving and elevated CR.

20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What are rapid response activities and who is responsible for providing them? 665.300 Section 665.300 Employees' Benefits EMPLOYMENT AND TRAINING... WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.300 What are rapid response activities and who is...

20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are rapid response activities and who is responsible for providing them? 665.300 Section 665.300 Employees' Benefits EMPLOYMENT AND TRAINING... INVESTMENT ACT Rapid Response Activities § 665.300 What are rapid response activities and who is responsible...

26 CFR 1.665(g)-1A - Capital gain distribution.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Capital gain distribution. 1.665(g)-1A Section 1.665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... Beginning on Or After January 1, 1969 § 1.665(g)-1A Capital gain distribution. For any taxable year of a...

26 CFR 1.665(g)-2A - Application of separate share rule.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Application of separate share rule. 1.665(g)-2A Section 1.665(g)-2A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Taxable Years Beginning on Or After January 1, 1969 § 1.665(g)-2A Application of separate share rule. (a...

26 CFR 1.665(g)-2A - Application of separate share rule.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Application of separate share rule. 1.665(g)-2A Section 1.665(g)-2A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Taxable Years Beginning on Or After January 1, 1969 § 1.665(g)-2A Application of separate share rule. (a...

26 CFR 1.665(g)-2A - Application of separate share rule.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Application of separate share rule. 1.665(g)-2A Section 1.665(g)-2A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Taxable Years Beginning on Or After January 1, 1969 § 1.665(g)-2A Application of separate share rule. (a...

26 CFR 1.665(g)-2A - Application of separate share rule.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Application of separate share rule. 1.665(g)-2A Section 1.665(g)-2A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Years Beginning on Or After January 1, 1969 § 1.665(g)-2A Application of separate share rule. (a) In...

26 CFR 1.665(g)-1A - Capital gain distribution.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Capital gain distribution. 1.665(g)-1A Section 1.665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... Beginning on Or After January 1, 1969 § 1.665(g)-1A Capital gain distribution. For any taxable year of a...

26 CFR 1.665(g)-2A - Application of separate share rule.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Application of separate share rule. 1.665(g)-2A Section 1.665(g)-2A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Taxable Years Beginning on Or After January 1, 1969 § 1.665(g)-2A Application of separate share rule. (a...

26 CFR 1.665(g)-1A - Capital gain distribution.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Capital gain distribution. 1.665(g)-1A Section 1.665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... Beginning on Or After January 1, 1969 § 1.665(g)-1A Capital gain distribution. For any taxable year of a...

26 CFR 1.665(g)-1A - Capital gain distribution.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Capital gain distribution. 1.665(g)-1A Section 1.665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... Beginning on Or After January 1, 1969 § 1.665(g)-1A Capital gain distribution. For any taxable year of a...

26 CFR 1.665(g)-1A - Capital gain distribution.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Capital gain distribution. 1.665(g)-1A Section 1.665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... Or After January 1, 1969 § 1.665(g)-1A Capital gain distribution. For any taxable year of a trust...

Antipsychotic treatment leading to dopamine supersensitivity persistently alters nucleus accumbens function.

PubMed

El Hage, Cynthia; Bédard, Anne-Marie; Samaha, Anne-Noël

2015-12-01

Chronic exposure to some antipsychotic medications can induce supersensitivity to dopamine receptor stimulation. This is linked to a worsening of clinical outcome and to antipsychotic treatment failure. Here we investigated the role of striatal subregions [nucleus accumbens (NAc) and caudate-putamen (CPu)] in the expression of antipsychotic-induced dopamine supersensitivity. We treated rats with haloperidol (HAL) or olanzapine (OLZ), using regimens that achieve clinically relevant kinetics of striatal D2 receptor occupancy. Under these conditions, HAL produces dopamine supersensitivity whereas OLZ does not. We then assessed behaviors evoked by the dopamine agonist amphetamine (AMPH). We either injected AMPH into the striatum or inhibited striatal function with microinjections of GABA receptor agonists prior to injecting AMPH systemically. HAL-treated rats were dopamine supersensitive, as indicated by sensitization to systemic AMPH-induced potentiation of both locomotor activity and operant responding for a conditioned reward (CR). Intra-CPu injections of AMPH had no effect on these behaviors, in any group. Intra-NAc injections of AMPH enhanced operant responding for CR in OLZ-treated and control rats, but not in HAL-treated rats. In HAL-treated rats, inhibition of the NAc also failed to disrupt systemic AMPH-induced potentiation of operant responding for CR. Furthermore, while intra-NAc AMPH enhanced locomotion in both HAL-treated and control animals, inhibition of the NAc disrupted systemic AMPH-induced locomotion only in control rats. Thus, antipsychotic-induced dopamine supersensitivity persistently disrupts NAc function, such that some behaviors that normally depend upon NAc dopamine no longer do so. This has implications for understanding dysfunctions in dopamine-mediated behaviors in patients undergoing chronic antipsychotic treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Targeting GPR30 in Abiraterone and MDV3100 Resistant Prostate Cancer

DTIC Science & Technology

2016-10-01

environment in vivo. We had previously demonstrated that G-1 inhibited growth in cell culture experiments and a hormone -independent PC-3Published by...coupled receptor 30 (GPR30) is a seven-transmembrane estrogen receptor and activation by its specific agonist G-1 inhibited growth in multiple...significantly inhibited the growth and extended the progression-free survival of patient-derived xenograft models that are sensitive (LuCaP 136CR, P

50 CFR 665.15 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., 665.399, or 665.599, any bottomfish MUS, crustacean MUS, western Pacific pelagic MUS, precious coral, seamount groundfish or coral reef ecosystem MUS. (m) Fail to comply with a term or condition governing the...

50 CFR 665.15 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., 665.399, or 665.599, any bottomfish MUS, crustacean MUS, western Pacific pelagic MUS, precious coral, seamount groundfish or coral reef ecosystem MUS. (m) Fail to comply with a term or condition governing the...

50 CFR 665.15 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., 665.399, or 665.599, any bottomfish MUS, crustacean MUS, western Pacific pelagic MUS, precious coral, seamount groundfish or coral reef ecosystem MUS. (m) Fail to comply with a term or condition governing the...

50 CFR 665.15 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., 665.399, or 665.599, any bottomfish MUS, crustacean MUS, western Pacific pelagic MUS, precious coral, seamount groundfish or coral reef ecosystem MUS. (m) Fail to comply with a term or condition governing the...

50 CFR 665.15 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., 665.399, or 665.599, any bottomfish MUS, crustacean MUS, western Pacific pelagic MUS, precious coral, seamount groundfish or coral reef ecosystem MUS. (m) Fail to comply with a term or condition governing the...

50 CFR 665.441 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Definitions. As used in §§ 665.440 through 665.459: Crustacean Permit Area 5 (Permit Area 5) means the EEZ... crustacean management unit species means the following crustaceans: Local name English common name Scientific...

50 CFR 665.441 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Definitions. As used in §§ 665.440 through 665.459: Crustacean Permit Area 5 (Permit Area 5) means the EEZ... crustacean management unit species means the following crustaceans: Local name English common name Scientific...

50 CFR 665.441 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Definitions. As used in §§ 665.440 through 665.459: Crustacean Permit Area 5 (Permit Area 5) means the EEZ... crustacean management unit species means the following crustaceans: Local name English common name Scientific...

50 CFR 665.441 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Definitions. As used in §§ 665.440 through 665.459: Crustacean Permit Area 5 (Permit Area 5) means the EEZ... crustacean management unit species means the following crustaceans: Local name English common name Scientific...

Development of a highly sensitive and specific monoclonal antibody based enzyme-linked immunosorbent assay for the detection of a new β-agonist, phenylethanolamine A, in food samples.

PubMed

Jiang, Danni; Cao, Biyun; Wang, Meiyu; Yang, Hong; Zhao, Kang; Li, Jianguo; Li, Mingxin; Sun, Lulu; Deng, Anping

2017-02-01

All β-agonists are banned as feed additives for growth promotion in animals due to toxic effects on humans after consuming the β-agonist contaminated meats. Phenylethanolamine A (PA) is a newly emerged β-agonist. Thus there is a need to develop highly sensitive and specific analytical methods for the detection of PA in food samples. In this study, the monoclonal antibody (mAb) against PA was produced by hybridoma technology and used for the development of enzyme-linked immunosorbent assay (ELISA). The IC 50 values and limits of detection (LODs) of the ELISA using homogeneous combination of coating antigen/antibody for PA were 0.16 ng mL -1 and 0.011 ng mL -1 , respectively. The cross-reactive (CR) values of the assay with 14 structurally related β-agonists were lower than 0.59%. Swine liver and meat samples were spiked with PA at different content and analysed by ELISA. Acceptable recovery rates of 91.40-105.51% and intra-assay coefficients of variation of 1.56-9.92% (n = 3) were obtained. The ELISA for seven spiked samples was confirmed by LC-MS/MS with a high correlation coefficient of 0.9881. The proposed mAb-based ELISA was highly sensitive and specific for PA and could be used as a quantitative/screening method for PA analysis in food samples. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes.

PubMed

Sun, Wen-Chong; Pei, Ling

2016-07-01

Propofol exerts a cytotoxic influence over immature neurocytes. Our previous study revealed that clinically relevant doses of propofol accelerated apoptosis of primary cultured astrocytes of developing rodent brains via rno-miR-665 regulation. However, the role of rno-miR-665 during the growth spurt of neonatal rodent brains in vivo is still uncertain. Post-natal day 7 (P7) rats received a single injection of propofol 30 mg/kg intraperitoneally (i.p.), and neuroapoptosis of hippocampal astrocytes was analyzed by immunofluorescence and scanning electron microscopy. The differential expression of rno-miR-665, BCL2L1 (Bcl-xl), and cleaved caspase 3 (CC3) was surveyed by qRT-PCR and western blotting. In addition, the utility of A-1155463, a highly potent and BCL2L1-selective antagonist, was aimed to assess the contribution of BCL2L1 for neuroglial survival. Following the intraventricular injection of lentivirus rno-miR-665, neuroprotection was detected by 5-point scale measurement. The single dose of propofol 30 mg/kg triggered dose-dependent apoptosis of developing hippocampal astrocytes. Meanwhile, propofol triggered both rno-miR-665 and CC3, and depressed BCL2L1, which was predicted as one target gene of rno-miR-665. Combination treatment with A-1155463 and propofol induced lower mRNA and protein levels of BCL2L1 and more CC3 activation than propofol treatment alone in vivo. The lentivirus-mediated knockdown of rno-miR-665 elevated BCL2L1 and attenuated CC3 levels, whereas up-regulation of rno-miR-665 suppressed BCL2L1 and induced CC3 expression in vivo. More importantly, rno-miR-665 antagomir infusion improved neurological outcomes of pups receiving propofol during the brain growth spurt. Rno-miR-665, providing a potential target for alternative therapeutics for pediatric anesthesia, is susceptible to propofol by negatively targeting antiapoptotic BCL2L1. Relatively little is known about the association between exposure of astrocytes to brief propofol anaesthesia and risk for impairment. Here, it revealed that propofol-related neurotoxicity of neonatal astrocytes was under rno-miR-665 regulation during the brain growth spurt. Rno-miR-665 might act as a clinically alternative therapeutic target for treatment of neurological disorders in peadiatric anesthesia or sedation with propofol in future. © 2016 International Society for Neurochemistry.

50 CFR 665.802 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... violation of § 665.814(d). (ee) Possess light sticks on board a vessel registered for use under a Hawaii... violation of § 665.815(a)(2)(v). (oo) Fail to maintain and use blue dye to prepare thawed bait when...

50 CFR 665.802 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... violation of § 665.814(d). (ee) Possess light sticks on board a vessel registered for use under a Hawaii... violation of § 665.815(a)(2)(v). (oo) Fail to maintain and use blue dye to prepare thawed bait when...

50 CFR 665.802 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... violation of § 665.814(d). (ee) Possess light sticks on board a vessel registered for use under a Hawaii... violation of § 665.815(a)(2)(v). (oo) Fail to maintain and use blue dye to prepare thawed bait when...

50 CFR 665.802 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... violation of § 665.814(d). (ee) Possess light sticks on board a vessel registered for use under a Hawaii... violation of § 665.815(a)(2)(v). (oo) Fail to maintain and use blue dye to prepare thawed bait when...

50 CFR 665.441 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... crustacean management unit species means the following crustaceans: Local name English common name Scientific... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Definitions. 665.441 Section 665.441 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

49 CFR 665.21 - Scheduling.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Scheduling. 665.21 Section 665.21 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF... available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting the...

50 CFR 665.403 - Bottomfish fishery area management.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Bottomfish fishery area management. 665.403 Section 665.403 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana...

50 CFR 665.440 - Mariana crustacean fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Mariana crustacean fisheries. [Reserved] 665.440 Section 665.440 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC...

50 CFR 665.440 - Mariana crustacean fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Mariana crustacean fisheries. [Reserved] 665.440 Section 665.440 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC...

50 CFR 665.240 - Hawaii crustacean fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Hawaii crustacean fisheries. [Reserved] 665.240 Section 665.240 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC...

50 CFR 665.400 - Mariana bottomfish fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Mariana bottomfish fisheries. [Reserved] 665.400 Section 665.400 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC...

50 CFR 665.400 - Mariana bottomfish fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Mariana bottomfish fisheries. [Reserved] 665.400 Section 665.400 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC...

50 CFR 665.100 - American Samoa bottomfish fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa bottomfish fisheries. [Reserved] 665.100 Section 665.100 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN...

50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false American Samoa Crustacean Fisheries. [Reserved] 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN...

50 CFR 665.100 - American Samoa bottomfish fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false American Samoa bottomfish fisheries. [Reserved] 665.100 Section 665.100 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN...

50 CFR 665.140 - American Samoa Crustacean Fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false American Samoa Crustacean Fisheries. [Reserved] 665.140 Section 665.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN...

50 CFR 665.202 - Management subareas.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management subareas. 665.202 Section 665.202 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Management subareas. (a) The Hawaii fishery management area is divided into subareas with the following...

50 CFR 665.202 - Management subareas.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management subareas. 665.202 Section 665.202 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Management subareas. (a) The Hawaii fishery management area is divided into subareas with the following...

50 CFR 665.202 - Management subareas.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management subareas. 665.202 Section 665.202 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Management subareas. (a) The Hawaii fishery management area is divided into subareas with the following...

50 CFR 665.202 - Management subareas.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management subareas. 665.202 Section 665.202 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Management subareas. (a) The Hawaii fishery management area is divided into subareas with the following...

10 CFR 603.665 - Periodic audits of nonprofit participants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Periodic audits of nonprofit participants. 603.665 Section 603.665 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters...

10 CFR 603.665 - Periodic audits of nonprofit participants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Periodic audits of nonprofit participants. 603.665 Section 603.665 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters...

50 CFR 665.210 - Hawaii restricted bottomfish species.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii restricted bottomfish species. 665... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.210 Hawaii restricted bottomfish species. Hawaii restricted bottomfish species means the...

50 CFR 665.202 - Management subareas.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management subareas. 665.202 Section 665.202 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Management subareas. (a) The Hawaii fishery management area is divided into subareas with the following...

50 CFR 665.642 - Permits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Permits. 665.642 Section 665.642 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... information sheet obtained from PIRO and contain the names and mailing addresses of all partners or...

50 CFR 665.442 - Permits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Permits. 665.442 Section 665.442 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... information sheet obtained from PIRO and contain the names and mailing addresses of all partners or...

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

PubMed

Pirat, Celine; Dacquet, Catherine; Leclerc, Veronique; Hennuyer, Nathalie; Beucher-Gaudin, Monique; Zanirato, Ghislaine; Géant, Anne; Staels, Bart; Ktorza, Alain; Farce, Amaury; Caignard, Daniel-Henri; Berthelot, Pascal; Lebegue, Nicolas

2017-09-08

A series of benzothiazol-2-one containing α-ethoxyphenylpropionic acid derivatives incorporating resveratrol or butein scaffolds were designed as fused full PPARγ agonist ligands and SIRT1-activating compounds for the treatment of type 2 diabetes (T2D) and its complications. Compound 14d displayed the best in vitro pharmacological profile with full PPARγ agonist activity (Emax = 98%, EC 50  = 200 nM), SIRT1 enzymatic activation (+128%) and SGK1 expression inhibition (- 57%) which is known to limit side effects as fluid retention and body-weight gain. Compound 14d showed high efficacy in an ob/ob mice model with significant decreases in serum triglyceride, glucose and insulin levels but mostly with limited body-weight gain by mimicking calorie restriction (CR) and inhibiting SGK1 expression. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

50 CFR 665.211 - Total Allowable Catch (TAC) limit.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Total Allowable Catch (TAC) limit. 665.211 Section 665.211 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii...

50 CFR 665.211 - Total Allowable Catch (TAC) limit.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Total Allowable Catch (TAC) limit. 665.211 Section 665.211 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii...

50 CFR 665.211 - Total Allowable Catch (TAC) limit.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Total Allowable Catch (TAC) limit. 665.211 Section 665.211 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii...

50 CFR 665.211 - Total Allowable Catch (TAC) limit.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Total Allowable Catch (TAC) limit. 665.211 Section 665.211 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii...

50 CFR 665.211 - Total Allowable Catch (TAC) limit.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Total Allowable Catch (TAC) limit. 665.211 Section 665.211 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii...

50 CFR 665.640 - PRIA crustacean fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false PRIA crustacean fisheries. [Reserved] 665.640 Section 665.640 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Pacific Remote...

50 CFR 665.600 - PRIA bottomfish fisheries. [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false PRIA bottomfish fisheries. [Reserved] 665.600 Section 665.600 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Pacific Remote...

50 CFR 665.640 - PRIA crustacean fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false PRIA crustacean fisheries. [Reserved] 665.640 Section 665.640 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Pacific Remote...

50 CFR 665.600 - PRIA bottomfish fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false PRIA bottomfish fisheries. [Reserved] 665.600 Section 665.600 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Pacific Remote...

50 CFR 665.798 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.798 Section 665.798 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....798 Management area. The western Pacific Pelagic fishery management area includes all areas of fishing...

50 CFR 665.798 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.798 Section 665.798 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....798 Management area. The western Pacific Pelagic fishery management area includes all areas of fishing...

50 CFR 665.798 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.798 Section 665.798 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....798 Management area. The western Pacific Pelagic fishery management area includes all areas of fishing...

50 CFR 665.798 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.798 Section 665.798 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....798 Management area. The western Pacific Pelagic fishery management area includes all areas of fishing...

50 CFR 665.246 - Gear identification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear identification. 665.246 Section 665.246 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Gear identification. In Permit Area 1, the vessel's official number must be marked legibly on all traps...

20 CFR 641.665 - When is eligibility determined?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false When is eligibility determined? 641.665 Section 641.665 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Private Sector Training Projects Under Section 502...

50 CFR 665.141 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Definitions. As used in §§ 665.140 through 665.159: American Samoa crustacean management unit species means the following crustaceans: Samoan name English common name Scientific name Ula spiny lobster Panulirus.... deepwater shrimp Heterocarpus spp. Crustacean Permit Area 3 (Permit Area 3) includes the EEZ around American...

50 CFR 665.141 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Definitions. As used in §§ 665.140 through 665.159: American Samoa crustacean management unit species means the following crustaceans: Samoan name English common name Scientific name Ula spiny lobster Panulirus.... deepwater shrimp Heterocarpus spp. Crustacean Permit Area 3 (Permit Area 3) includes the EEZ around American...

50 CFR 665.141 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Definitions. As used in §§ 665.140 through 665.159: American Samoa crustacean management unit species means the following crustaceans: Samoan name English common name Scientific name Ula spiny lobster Panulirus.... deepwater shrimp Heterocarpus spp. Crustacean Permit Area 3 (Permit Area 3) includes the EEZ around American...

50 CFR 665.802 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Prohibitions. 665.802 Section 665.802 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...)(2). (nn) Fail to employ basket-style longline gear such that the mainline is deployed slack when...

50 CFR 665.798 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.798 Section 665.798 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....798 Management area. The western Pacific Pelagic fishery management area includes all areas of fishing...

50 CFR 665.142 - Permits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Permits. 665.142 Section 665.142 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... sheet obtained from PIRO and contain the names and mailing addresses of all partners or shareholders and...

49 CFR 665.5 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... used in public transportation service in the United States before October 1, 1988; or (2) Has been used... corresponding baseline bus configuration. Public transportation service means the operation of a vehicle that... 49 Transportation 7 2010-10-01 2010-10-01 false Definitions. 665.5 Section 665.5 Transportation...

50 CFR 665.200 - Hawaii bottomfish and seamount groundfish fisheries. [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Hawaii bottomfish and seamount groundfish fisheries. [Reserved] 665.200 Section 665.200 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE...

50 CFR 665.398 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.398 Section 665.398 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana fishery management area is the EEZ seaward of Guam and CNMI with the inner...

50 CFR 665.98 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

50 CFR 665.398 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.398 Section 665.398 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana fishery management area is the EEZ seaward of Guam and CNMI with the inner...

50 CFR 665.98 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

50 CFR 665.398 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.398 Section 665.398 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana fishery management area is the EEZ seaward of Guam and CNMI with the inner...

50 CFR 665.98 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

50 CFR 665.98 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

50 CFR 665.398 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.398 Section 665.398 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana fishery management area is the EEZ seaward of Guam and CNMI with the inner...

50 CFR 665.464 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.464 Section 665.464 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Gear restrictions. Only selective gear may be used to harvest coral from any precious coral permit area. ...

7 CFR 1944.665 - Supervision and inspection of work.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 13 2011-01-01 2009-01-01 true Supervision and inspection of work. 1944.665 Section 1944.665 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Supervision and inspection of work. Grantees are responsible for supervising all rehabilitation and repair...

7 CFR 1944.665 - Supervision and inspection of work.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 13 2014-01-01 2013-01-01 true Supervision and inspection of work. 1944.665 Section 1944.665 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Supervision and inspection of work. Grantees are responsible for supervising all rehabilitation and repair...

7 CFR 1944.665 - Supervision and inspection of work.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 13 2013-01-01 2013-01-01 false Supervision and inspection of work. 1944.665 Section 1944.665 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Supervision and inspection of work. Grantees are responsible for supervising all rehabilitation and repair...

7 CFR 1944.665 - Supervision and inspection of work.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 13 2012-01-01 2012-01-01 false Supervision and inspection of work. 1944.665 Section 1944.665 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Supervision and inspection of work. Grantees are responsible for supervising all rehabilitation and repair...

7 CFR 1944.665 - Supervision and inspection of work.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Supervision and inspection of work. 1944.665 Section 1944.665 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Supervision and inspection of work. Grantees are responsible for supervising all rehabilitation and repair...

50 CFR 665.169 - Gold coral harvest moratorium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gold coral harvest moratorium. 665.169... Fisheries § 665.169 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.261 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... As used in §§ 665.260 through 665.270: Hawaii precious coral management unit species (Hawaii precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium secundum, Corallium...

50 CFR 665.261 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... As used in §§ 665.260 through 665.270: Hawaii precious coral management unit species (Hawaii precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium secundum, Corallium...

50 CFR 665.261 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... As used in §§ 665.260 through 665.270: Hawaii precious coral management unit species (Hawaii precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium secundum, Corallium...

50 CFR 665.169 - Gold coral harvest moratorium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gold coral harvest moratorium. 665.169... Fisheries § 665.169 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.469 - Gold coral harvest moratorium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gold coral harvest moratorium. 665.469... Archipelago Fisheries § 665.469 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.270 - Gold coral harvest moratorium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gold coral harvest moratorium. 665.270... Fisheries § 665.270 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.169 - Gold coral harvest moratorium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gold coral harvest moratorium. 665.169... Fisheries § 665.169 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.261 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... As used in §§ 665.260 through 665.270: Hawaii precious coral management unit species (Hawaii precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium secundum, Corallium...

50 CFR 665.469 - Gold coral harvest moratorium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gold coral harvest moratorium. 665.469... Archipelago Fisheries § 665.469 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.270 - Gold coral harvest moratorium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gold coral harvest moratorium. 665.270... Fisheries § 665.270 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.469 - Gold coral harvest moratorium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gold coral harvest moratorium. 665.469... Archipelago Fisheries § 665.469 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.270 - Gold coral harvest moratorium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gold coral harvest moratorium. 665.270... Fisheries § 665.270 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.261 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... As used in §§ 665.260 through 665.270: Hawaii precious coral management unit species (Hawaii precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: English common name Scientific name Pink coral (also known as red coral) Corallium secundum, Corallium...

20 CFR 665.210 - What are allowable Statewide workforce investment activities?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What are allowable Statewide workforce investment activities? 665.210 Section 665.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... assist in skills upgrading; and (2) Programs targeted to Empowerment Zones and Enterprise Communities. (e...

20 CFR 665.210 - What are allowable Statewide workforce investment activities?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What are allowable Statewide workforce investment activities? 665.210 Section 665.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... loan program to assist in skills upgrading; and (2) Programs targeted to Empowerment Zones and...

20 CFR 665.210 - What are allowable Statewide workforce investment activities?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false What are allowable Statewide workforce investment activities? 665.210 Section 665.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... loan program to assist in skills upgrading; and (2) Programs targeted to Empowerment Zones and...

20 CFR 665.210 - What are allowable Statewide workforce investment activities?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are allowable Statewide workforce investment activities? 665.210 Section 665.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... assist in skills upgrading; and (2) Programs targeted to Empowerment Zones and Enterprise Communities. (e...

20 CFR 665.210 - What are allowable Statewide workforce investment activities?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false What are allowable Statewide workforce investment activities? 665.210 Section 665.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... loan program to assist in skills upgrading; and (2) Programs targeted to Empowerment Zones and...

50 CFR 665.398 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.398 Section 665.398 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana fishery management area is the EEZ seaward of Guam and CNMI with the inner...

50 CFR 665.98 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

Xenoestrogenic and dioxin-like activity in blood of East Greenland polar bears (Ursus maritimus).

PubMed

Erdmann, Simon E; Dietz, Rune; Sonne, Christian; Bechshøft, Thea Ø; Vorkamp, Katrin; Letcher, Robert J; Long, Manhai; Bonefeld-Jørgensen, Eva C

2013-07-01

The aims of the project were to (i) extract the lipophilic persistent organic pollutants (POPs) from the blood of 99 East Greenland polar bears and assess the combined mixture effect on the estrogen receptor (ER) and the aryl hydrocarbon receptor (AhR) mediated transactivity; (ii) To evaluate whether the receptor transactivities were associated with selected POP markers, and (iii) compare the receptor transactivities in polar bears with earlier studies on Greenlandic Inuit. Lipophilic POPs were extracted using a combination of solid-phase extraction (SPE) and high performance liquid chromatography (HPLC). ER mediated transactivity was determined using the ER luciferase reporter MVLN cell assay. The extracts were tested alone (XER) and together with 17β-estradiol (E2) as a physiological mimic (XERcomp). Dioxins and dioxin-like (DL) compounds were extracted by a combination of SPE and the Supelco Dioxin Prep System®. AhR mediated dioxin-like transactivity was determined using the AhR luciferase reporter Hepa 1.12cR cell assay. Agonistic ER transactivity was elicited by 19% of the samples, and a further increased E2 induced ER response was found for 52%, whereas 17% antagonized the E2 induced ER response. Positive correlations were found in subadult bears between XER and several POP biomarkers. XER and XERcomp correlated positively to each other. A total of 91% of the polar bear blood extracts elicited agonistic AhR transactivity. The AhR-TCDD equivalent (AhR-TEQ) median levels were higher among adult bears compared to subadult bears, but not significantly. Copyright © 2013 Elsevier Ltd. All rights reserved.

50 CFR 665.421 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Definitions. As used in §§ 665.420 through 665.439: Mariana coral reef ecosystem management unit species (Mariana coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.221 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... As used in §§ 665.220 through 665.239: Hawaii coral reef ecosystem management unit species (Hawaii coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.221 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... As used in §§ 665.220 through 665.239: Hawaii coral reef ecosystem management unit species (Hawaii coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.221 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... As used in §§ 665.220 through 665.239: Hawaii coral reef ecosystem management unit species (Hawaii coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.421 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Definitions. As used in §§ 665.420 through 665.439: Mariana coral reef ecosystem management unit species (Mariana coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.421 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Definitions. As used in §§ 665.420 through 665.439: Mariana coral reef ecosystem management unit species (Mariana coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.121 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Definitions. As used in §§ 665.120 through 665.139: American Samoa coral reef ecosystem management unit species (American Samoa coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.421 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Definitions. As used in §§ 665.420 through 665.439: Mariana coral reef ecosystem management unit species (Mariana coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.221 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... As used in §§ 665.220 through 665.239: Hawaii coral reef ecosystem management unit species (Hawaii coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.121 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Definitions. As used in §§ 665.120 through 665.139: American Samoa coral reef ecosystem management unit species (American Samoa coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic...

50 CFR 665.421 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Definitions. As used in §§ 665.420 through 665.439: Mariana coral reef ecosystem management unit species (Mariana coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

50 CFR 665.221 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... As used in §§ 665.220 through 665.239: Hawaii coral reef ecosystem management unit species (Hawaii coral reef ecosystem MUS) means all of the Currently Harvested Coral Reef Taxa and Potentially Harvested Coral Reef Taxa listed in this section and which spend the majority of their non-pelagic (post...

22 CFR 66.5 - Availability of NED records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Availability of NED records. 66.5 Section 66.5 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES AVAILABILITY OF THE RECORDS OF THE... actually incurs in searching for and duplicating (and in the case of commercial requesters, reviewing...

50 CFR 665.422 - Management area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Management area. 665.422 Section 665.422 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana coral reef management area consists of the U.S. EEZ around Guam and the offshore...

50 CFR 665.422 - Management area.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Management area. 665.422 Section 665.422 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana coral reef management area consists of the U.S. EEZ around Guam and the offshore...

50 CFR 665.422 - Management area.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Management area. 665.422 Section 665.422 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana coral reef management area consists of the U.S. EEZ around Guam and the offshore...

50 CFR 665.422 - Management area.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Management area. 665.422 Section 665.422 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana coral reef management area consists of the U.S. EEZ around Guam and the offshore...

50 CFR 665.812 - Sea turtle take mitigation measures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Sea turtle take mitigation measures. 665... Pacific Pelagic Fisheries § 665.812 Sea turtle take mitigation measures. (a) Possession and use of... sea turtle handling requirements set forth in paragraph (b) of this section. (1) Hawaii longline...

50 CFR 665.812 - Sea turtle take mitigation measures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Sea turtle take mitigation measures. 665... Pacific Pelagic Fisheries § 665.812 Sea turtle take mitigation measures. (a) Possession and use of... sea turtle handling requirements set forth in paragraph (b) of this section. (1) Hawaii longline...

50 CFR 665.812 - Sea turtle take mitigation measures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Sea turtle take mitigation measures. 665... Pacific Pelagic Fisheries § 665.812 Sea turtle take mitigation measures. (a) Possession and use of... sea turtle handling requirements set forth in paragraph (b) of this section. (1) Hawaii longline...

50 CFR 665.812 - Sea turtle take mitigation measures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Sea turtle take mitigation measures. 665... Pacific Pelagic Fisheries § 665.812 Sea turtle take mitigation measures. (a) Possession and use of... sea turtle handling requirements set forth in paragraph (b) of this section. (1) Hawaii longline...

36 CFR 1212.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false State. 1212.665 Section 1212... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1212.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico...

38 CFR 48.665 - State.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false State. 48.665 Section 48... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 48.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory...

50 CFR Figure 1 to Part 665 - Carapace Length of Lobsters

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Carapace Length of Lobsters 1 Figure 1 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Carapace Length of Lobsters ER14JA10.126 ...

50 CFR Figure 1 to Part 665 - Carapace Length of Lobsters

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Carapace Length of Lobsters 1 Figure 1 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Carapace Length of Lobsters ER14JA10.126 ...

50 CFR 665.2 - Relation to other laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Relation to other laws. 665.2 Section 665.2 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... other laws. NMFS recognizes that any state law pertaining to vessels registered under the laws of that...

27 CFR 19.665 - Alternate methods or procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Alternate methods or procedures. 19.665 Section 19.665 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Distilled Spirits for Fuel Use...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name English common name Scientific name Amu piniki-mumu Pink coral (also known...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name English common name Scientific name Amu piniki-mumu Pink coral (also known...

50 CFR 665.669 - Gold coral harvest moratorium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Gold coral harvest moratorium. 665.669... Island Area Fisheries § 665.669 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

50 CFR 665.669 - Gold coral harvest moratorium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gold coral harvest moratorium. 665.669... Island Area Fisheries § 665.669 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

50 CFR 665.669 - Gold coral harvest moratorium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Gold coral harvest moratorium. 665.669... Island Area Fisheries § 665.669 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2013. ...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

50 CFR Figure 2 to Part 665 - Length of Fishing Vessels

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Length of Fishing Vessels 2 Figure 2 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Length of Fishing Vessels ER14JA10.127 ...

50 CFR Figure 2 to Part 665 - Length of Fishing Vessels

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Length of Fishing Vessels 2 Figure 2 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Length of Fishing Vessels ER14JA10.127 ...

50 CFR Figure 2 to Part 665 - Length of Fishing Vessels

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Length of Fishing Vessels 2 Figure 2 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Length of Fishing Vessels ER14JA10.127 ...

50 CFR Figure 2 to Part 665 - Length of Fishing Vessels

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Length of Fishing Vessels 2 Figure 2 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Length of Fishing Vessels ER14JA10.127 ...

50 CFR Figure 2 to Part 665 - Length of Fishing Vessels

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Length of Fishing Vessels 2 Figure 2 to Part 665 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Part 665—Length of Fishing Vessels ER14JA10.127 ...

50 CFR 665.815 - Pelagic longline seabird mitigation measures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pelagic longline seabird mitigation measures. 665.815 Section 665.815 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... and livers in accordance with paragraph (a)(2)(i) of this section; (v) When using basket-style...

50 CFR 665.422 - Management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.422 Section 665.422 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The Mariana coral reef management area consists of the U.S. EEZ around Guam and the offshore...

33 CFR 149.665 - What are the requirements for a general alarm system?

Code of Federal Regulations, 2011 CFR

2011-07-01

...? Each pumping platform complex must have a general alarm system that: (a) Is capable of being manually... general alarm system? 149.665 Section 149.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: DESIGN, CONSTRUCTION, AND EQUIPMENT Design...

33 CFR 149.665 - What are the requirements for a general alarm system?

Code of Federal Regulations, 2010 CFR

2010-07-01

...? Each pumping platform complex must have a general alarm system that: (a) Is capable of being manually... general alarm system? 149.665 Section 149.665 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: DESIGN, CONSTRUCTION, AND EQUIPMENT Design...

41 CFR 102-75.665 - What happens after the disposal agency receives the assignment recommendation from DOI?

Code of Federal Regulations, 2010 CFR

2010-07-01

... disposal agency receives the assignment recommendation from DOI? 102-75.665 Section 102-75.665 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL... assignment recommendation from DOI? If, after considering other uses for the property, the disposal agency...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.14 - Reporting and recordkeeping.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of each landing of coral reef ecosystem MUS. (d) Sales report. The operator of any fishing vessel... copying upon request by an authorized officer. (4) Coral reef ecosystem MUS. Any person who has a special... effort, landings and sales for coral reef ecosystem MUS by this subpart and §§ 665.120 through 665.128...

50 CFR 665.14 - Reporting and recordkeeping.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of each landing of coral reef ecosystem MUS. (d) Sales report. The operator of any fishing vessel... copying upon request by an authorized officer. (4) Coral reef ecosystem MUS. Any person who has a special... effort, landings and sales for coral reef ecosystem MUS by this subpart and §§ 665.120 through 665.128...

50 CFR 665.14 - Reporting and recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of each landing of coral reef ecosystem MUS. (d) Sales report. The operator of any fishing vessel... copying upon request by an authorized officer. (4) Coral reef ecosystem MUS. Any person who has a special... effort, landings and sales for coral reef ecosystem MUS by this subpart and §§ 665.120 through 665.128...

50 CFR 665.399 - Area restrictions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Area restrictions. 665.399 Section 665.399 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... the U.S. EEZ seaward of Guam west of 144°30′ E. long. except in the event of an emergency caused by...

50 CFR 665.243 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... crustacean management area except as provided in § 665.245. (5) Maintain on board the vessel or in the water... vessel that has a limited access permit issued under § 665.242 any lobster trap in Crustacean Permit Area... issued under this subpart any lobster trap in Crustacean Permit Area 1 VMS Subarea when fishing for...

50 CFR 665.243 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... crustacean management area except as provided in § 665.245. (5) Maintain on board the vessel or in the water... vessel that has a limited access permit issued under § 665.242 any lobster trap in Crustacean Permit Area... issued under this subpart any lobster trap in Crustacean Permit Area 1 VMS Subarea when fishing for...

50 CFR 665.241 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... As used in §§ 665.240 through 665.259: Hawaii crustacean management area is divided into the following areas: (1) Crustacean Permit Area 1 (Permit Area 1) means the EEZ around the NWHI. (2) Crustacean Permit Area 2 (Permit Area 2) means the EEZ around the MHI. (3) Crustacean Permit Area 1 VMS Subarea...

50 CFR 665.241 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... As used in §§ 665.240 through 665.259: Hawaii crustacean management area is divided into the following areas: (1) Crustacean Permit Area 1 (Permit Area 1) means the EEZ around the NWHI. (2) Crustacean Permit Area 2 (Permit Area 2) means the EEZ around the MHI. (3) Crustacean Permit Area 1 VMS Subarea...

50 CFR 665.243 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... crustacean management area except as provided in § 665.245. (5) Maintain on board the vessel or in the water... vessel that has a limited access permit issued under § 665.242 any lobster trap in Crustacean Permit Area... issued under this subpart any lobster trap in Crustacean Permit Area 1 VMS Subarea when fishing for...

50 CFR 665.241 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... As used in §§ 665.240 through 665.259: Hawaii crustacean management area is divided into the following areas: (1) Crustacean Permit Area 1 (Permit Area 1) means the EEZ around the NWHI. (2) Crustacean Permit Area 2 (Permit Area 2) means the EEZ around the MHI. (3) Crustacean Permit Area 1 VMS Subarea...

50 CFR 665.469 - Gold coral harvest moratorium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gold coral harvest moratorium. 665.469... Archipelago Fisheries § 665.469 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.669 - Gold coral harvest moratorium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gold coral harvest moratorium. 665.669... Island Area Fisheries § 665.669 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.667 - Quotas.

Code of Federal Regulations, 2014 CFR

2014-10-01

... § 665.667 Quotas. (a) General. The quotas limiting the amount of precious coral that may be taken in any precious coral permit area during the fishing year are listed in § 665.667(d). Only live coral is counted.... A conditional bed will be closed to all nonselective coral harvesting after the quota for one...

50 CFR 665.662 - Permits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... coral MUS in any PRIA precious coral permit area must have a permit issued under § 665.13. (b) Each permit will be valid for fishing only in the permit area specified on the permit. Precious Coral Permit... surrendering to the Regional Administrator any current permit for the precious coral fishery issued under § 665...

50 CFR 665.662 - Permits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... coral MUS in any PRIA precious coral permit area must have a permit issued under § 665.13. (b) Each permit will be valid for fishing only in the permit area specified on the permit. Precious Coral Permit... surrendering to the Regional Administrator any current permit for the precious coral fishery issued under § 665...

50 CFR 665.662 - Permits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... coral MUS in any PRIA precious coral permit area must have a permit issued under § 665.13. (b) Each permit will be valid for fishing only in the permit area specified on the permit. Precious Coral Permit... surrendering to the Regional Administrator any current permit for the precious coral fishery issued under § 665...

50 CFR 665.270 - Gold coral harvest moratorium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gold coral harvest moratorium. 665.270... Fisheries § 665.270 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.469 - Gold coral harvest moratorium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gold coral harvest moratorium. 665.469... Archipelago Fisheries § 665.469 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.270 - Gold coral harvest moratorium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gold coral harvest moratorium. 665.270... Fisheries § 665.270 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.667 - Quotas.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 665.667 Quotas. (a) General. The quotas limiting the amount of precious coral that may be taken in any precious coral permit area during the fishing year are listed in § 665.667(d). Only live coral is counted.... A conditional bed will be closed to all nonselective coral harvesting after the quota for one...

50 CFR 665.169 - Gold coral harvest moratorium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Gold coral harvest moratorium. 665.169... Fisheries § 665.169 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.662 - Permits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... coral MUS in any PRIA precious coral permit area must have a permit issued under § 665.13. (b) Each permit will be valid for fishing only in the permit area specified on the permit. Precious Coral Permit... surrendering to the Regional Administrator any current permit for the precious coral fishery issued under § 665...

50 CFR 665.669 - Gold coral harvest moratorium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gold coral harvest moratorium. 665.669... Island Area Fisheries § 665.669 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.662 - Permits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... coral MUS in any PRIA precious coral permit area must have a permit issued under § 665.13. (b) Each permit will be valid for fishing only in the permit area specified on the permit. Precious Coral Permit... surrendering to the Regional Administrator any current permit for the precious coral fishery issued under § 665...

50 CFR 665.667 - Quotas.

Code of Federal Regulations, 2012 CFR

2012-10-01

... § 665.667 Quotas. (a) General. The quotas limiting the amount of precious coral that may be taken in any precious coral permit area during the fishing year are listed in § 665.667(d). Only live coral is counted.... A conditional bed will be closed to all nonselective coral harvesting after the quota for one...

50 CFR 665.169 - Gold coral harvest moratorium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Gold coral harvest moratorium. 665.169... Fisheries § 665.169 Gold coral harvest moratorium. Fishing for, taking, or retaining any gold coral in any precious coral permit area is prohibited through June 30, 2018. [78 FR 32182, May 29, 2013] ...

50 CFR 665.935 - Fishing permit procedures and criteria.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Fishing permit procedures and criteria... Pacific Remote Islands Marine National Monument § 665.935 Fishing permit procedures and criteria. (a) Non-commercial fishing—(1) Applicability. Except as provided in section 665.934(d), a vessel that is used to non...

50 CFR 665.935 - Fishing permit procedures and criteria.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Fishing permit procedures and criteria... Pacific Remote Islands Marine National Monument § 665.935 Fishing permit procedures and criteria. (a) Non-commercial fishing—(1) Applicability. Except as provided in section 665.934(d), a vessel that is used to non...

The non-biphenyl-tetrazole angiotensin AT1 receptor antagonist eprosartan is a unique and robust inverse agonist of the active state of the AT1 receptor.

PubMed

Takezako, Takanobu; Unal, Hamiyet; Karnik, Sadashiva S; Node, Koichi

2018-03-23

Conditions such as hypertension and renal allograft rejection are accompanied by chronic, agonist-independent, signalling by angiotensin II AT 1 receptors. The current treatment paradigm for these diseases entails the preferred use of inverse agonist AT 1 receptor blockers (ARBs). However, variability in the inverse agonist activities of common biphenyl-tetrazole ARBs for the active state of AT 1 receptors often leads to treatment failure. Therefore, characterization of robust inverse agonist ARBs for the active state of AT 1 receptors is necessary. To identify the robust inverse agonist for active state of AT 1 receptors and its molecular mechanism, we performed site-directed mutagenesis, competition binding assay, inositol phosphate production assay and molecular modelling for both ground-state wild-type AT 1 receptors and active-state N111G mutant AT 1 receptors. Although candesartan and telmisartan exhibited weaker inverse agonist activity for N111G- compared with WT-AT 1 receptors, only eprosartan exhibited robust inverse agonist activity for both N111G- and WT- AT 1 receptors. Specific ligand-receptor contacts for candesartan and telmisartan are altered in the active-state N111G- AT 1 receptors compared with the ground-state WT-AT 1 receptors, suggesting an explanation of their attenuated inverse agonist activity for the active state of AT 1 receptors. In contrast, interactions between eprosartan and N111G-AT 1 receptors were not significantly altered, and the inverse agonist activity of eprosartan was robust. Eprosartan may be a better therapeutic option than other ARBs. Comparative studies investigating eprosartan and other ARBs for the treatment of diseases caused by chronic, agonist-independent, AT 1 receptor activation are warranted. © 2018 The British Pharmacological Society.

ePrescribing: Reducing Costs through In-Class Therapeutic Interchange.

PubMed

Stenner, Shane P; Chakravarthy, Rohini; Johnson, Kevin B; Miller, William L; Olson, Julie; Wickizer, Marleen; Johnson, Nate N; Ohmer, Rick; Uskavitch, David R; Bernard, Gordon R; Neal, Erin B; Lehmann, Christoph U

2016-12-14

Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. For all medication classes, significant improvements were demonstrated - the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan - $17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates.

50 CFR 665.625 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., possess or land any PRIA coral reef ecosystem MUS in any low-use MPA as defined in § 665.599 unless: (1) A... applicable area of harvest; (2) A permit is not required, as outlined in § 665.624; (3) The PRIA coral reef..., take, or retain any PRIA coral reef ecosystem MUS species: (1) That is determined overfished with...

50 CFR 665.225 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... land any Hawaii coral reef ecosystem MUS in any low-use MPA as defined in § 665.199 unless: (1) A valid..., take, or retain any Hawaii coral reef ecosystem MUS species: (1) That is determined overfished with... applicable area of harvest; (2) A permit is not required, as outlined in § 665.224; or (3) The Hawaii coral...

50 CFR 665.225 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... land any Hawaii coral reef ecosystem MUS in any low-use MPA as defined in § 665.199 unless: (1) A valid..., take, or retain any Hawaii coral reef ecosystem MUS species: (1) That is determined overfished with... applicable area of harvest; (2) A permit is not required, as outlined in § 665.224; or (3) The Hawaii coral...

50 CFR 665.225 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... land any Hawaii coral reef ecosystem MUS in any low-use MPA as defined in § 665.199 unless: (1) A valid..., take, or retain any Hawaii coral reef ecosystem MUS species: (1) That is determined overfished with... applicable area of harvest; (2) A permit is not required, as outlined in § 665.224; or (3) The Hawaii coral...

50 CFR 665.225 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... land any Hawaii coral reef ecosystem MUS in any low-use MPA as defined in § 665.199 unless: (1) A valid..., take, or retain any Hawaii coral reef ecosystem MUS species: (1) That is determined overfished with... applicable area of harvest; (2) A permit is not required, as outlined in § 665.224; or (3) The Hawaii coral...

50 CFR 665.625 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., possess or land any PRIA coral reef ecosystem MUS in any low-use MPA as defined in § 665.599 unless: (1) A... applicable area of harvest; (2) A permit is not required, as outlined in § 665.624; (3) The PRIA coral reef..., take, or retain any PRIA coral reef ecosystem MUS species: (1) That is determined overfished with...

50 CFR 665.625 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., possess or land any PRIA coral reef ecosystem MUS in any low-use MPA as defined in § 665.599 unless: (1) A... applicable area of harvest; (2) A permit is not required, as outlined in § 665.624; (3) The PRIA coral reef..., take, or retain any PRIA coral reef ecosystem MUS species: (1) That is determined overfished with...

50 CFR 665.225 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... land any Hawaii coral reef ecosystem MUS in any low-use MPA as defined in § 665.199 unless: (1) A valid..., take, or retain any Hawaii coral reef ecosystem MUS species: (1) That is determined overfished with... applicable area of harvest; (2) A permit is not required, as outlined in § 665.224; or (3) The Hawaii coral...

41 CFR 102-75.665 - What happens after the disposal agency receives the assignment recommendation from DOI?

Code of Federal Regulations, 2011 CFR

2011-01-01

... disposal agency receives the assignment recommendation from DOI? 102-75.665 Section 102-75.665 Public... assignment recommendation from DOI? If, after considering other uses for the property, the disposal agency approves the assignment recommendation from DOI, it must assign the property by letter or other document to...

Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia.

PubMed

Barikbin, Behrooz; Khodamrdi, Zeinab; Kholoosi, Leila; Akhgri, Mohammad Reza; Haj Abbasi, Majid; Hajabbasi, Mojgan; Razzaghi, Zahra; Akbarpour, Samaneh

2017-05-17

This study aimed to evaluate the effectiveness of a combined set of low level diode laser scanner (665 nm and 808nm) on hair growth, and assessment of safety and effectiveness of a new laser scanner on hair growth treatment procedure in androgenic alopecia. 90 patients (18 to 70 years) with androgenic alopecia were randomized into three groups. The first group (n=30) received 655 nm red light using laser hat, the second group (n=30) received 655 nm red laser plus 808 nm infrared laser using a laser scanner of hair growth device (with the patent number: 77733) and the third group (n=30) received no laser as the control group. Patients in laser scanner group had better results and showed a higher increase in terminal hair density compared with laser hat group (mean of 9.61 versus 9.16 per cm 2 ). We found significant decrease in terminal hair density from baseline in control group (mean -1.8 per cm 2 , p<0.0001). Results showed a statistically significant improvement in the laser scanner of the hair growth group compared with laser hat and the control group. The study showed that treatment with new laser devise had a promising result without any observable adverse effects.

77 FR 27055 - Proposed Settlement Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... rehearing or rehearing en banc of the DC Circuit's opinion in Portland Cement Ass'n v. EPA, 665 F. 3d 177... Portland Cement Ass'n v. EPA, 665 F. 3d 177 (D.C. Cir. 2011), which involved National Emission Standards...'n v. EPA, 665 F. 3d 177, 186-189 (D.C. Cir. 2011). Following issuance of the court's opinion, but...

FAST CHOPPER DETECTOR HOUSE, TRA665. SECOND FLOOR ADDITION: PLAN, SECTIONS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FAST CHOPPER DETECTOR HOUSE, TRA-665. SECOND FLOOR ADDITION: PLAN, SECTIONS AND DETAILS AS ADDED TO THE EXISTING CHOPPER HOUSE IN 1962. F.C. TORKELSON 842-MTR-665-S-3, 4/1962. INL INDEX NO. 531-0665-60-851-150997, REV. 3. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

26 CFR 1.665(d)-1 - Taxes imposed on the trust.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Taxes imposed on the trust. 1.665(d)-1 Section 1... (CONTINUED) INCOME TAXES Treatment of Excess Distributions of Trusts Applicable to Taxable Years Beginning Before January 1, 1969 § 1.665(d)-1 Taxes imposed on the trust. (a) For the purpose of subpart D (section...

26 CFR 1.665(d)-1A - Taxes imposed on the trust.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Taxes imposed on the trust. 1.665(d)-1A Section... TAX (CONTINUED) INCOME TAXES Treatment of Excess Distributions of Trusts Applicable to Taxable Years Beginning on Or After January 1, 1969 § 1.665(d)-1A Taxes imposed on the trust. (a) In general. (1) For...

26 CFR 1.665(b)-1 - Accumulation distributions of trusts other than certain foreign trusts; in general.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Accumulation distributions of trusts other than certain foreign trusts; in general. 1.665(b)-1 Section 1.665(b)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Treatment of Excess Distributions of Trusts Applicable to Taxable...

Effects of Supplemental Chromium Source and Concentration on Growth, Carcass Characteristics, and Serum Lipid Parameters of Broilers Reared Under Normal Conditions.

PubMed

Zheng, Cancai; Huang, Yanling; Xiao, Fang; Lin, Xi; Lloyd, Karen

2016-02-01

An experiment was conducted to investigate the effects of dietary chromium (Cr) source and concentration on growth performance, carcass traits, and some serum lipid parameters of broilers under normal rearing conditions for 42 days. A total of 252 1-day-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate cages (six broilers per cage) for each of seven treatments in a completely randomized design involved in a 2 × 3 factorial arrangement of treatments with three Cr sources (Cr propionate (CrPro), Cr picolinate (CrPic), Cr chloride (CrCl3)) and two concentrations of added Cr (0.4 and 2.0 mg of Cr/kg) plus a Cr-unsupplemented control diet. The results showed that dietary Cr supplementation tended to increase the breast muscle percentage compared with the Cr-unsupplemented control group (P = 0.0784), while Cr from CrPic tended to have higher breast muscle percentage compared with Cr from CrCl3 (P = 0.0881). Chromium from CrPic also tended to increase the breast intramuscular fat (IMF) compared with Cr from CrCl3 (P = 0.0648). In addition, supplementation of 0.4 mg/kg Cr tended to decrease low-density lipoprotein cholesterol (LDL-C) (P = 0.0614). Compared with the control group, broilers fed Cr-supplemented diets had higher triglyceride (TG) (P = 0.0129) regardless of Cr source and Cr concentration. Chromium from CrPro and CrPic had lower total cholesterol (TC) compared with Cr from CrCl3 (P = 0.0220). These results indicate that dietary supplementation of Cr has effects on carcass characteristics and serum lipid parameters of broilers under normal rearing conditions, while supplementation of organic Cr can improve carcass characteristics and reduce the cholesterol content in serum.

Pediatric Asthma Mortality and Hospitalization Trends Across Asia Pacific Relationship With Asthma Drug Utilization Patterns

PubMed Central

2009-01-01

Background The wide variability in prevalence of childhood asthma across Asia Pacific is well documented, but less is known about its trends in mortality and hospitalization. Objectives To examine pediatric asthma mortality and hospitalization trends of selected countries across Asia Pacific, and also patterns of asthma drug utilization. Materials and Methods Mortality and population data were sourced from the World Health Organization's mortality database. Data on hospitalization were obtained by direct inquiry and from government and scientific publications. Drug use for asthma was expressed as a controller-to-reliever (C:R) ratio (ie, units of inhaled corticosteroids/units of short-acting β-agonists, sold in each country). Time-series regression analyses were used to examine temporal patterns and study association between deaths, hospitalizations, and drug use. Results Japan showed a decreasing trend in pediatric asthma mortality whereas an increase was observed in Thailand. Hospitalizations decreased in Australia and Singapore but increased in Taiwan, Republic of China. C:R ratios increased significantly across the countries. Conclusions Mixed trends in pediatric asthma mortality and hospitalization rates were observed, which coincided with a uniform increase in C:R ratios. This may reflect importance of other aspects of asthma management besides pharmacotherapy. PMID:23283014

Synthesis, characterisation and thermoelectric properties of the oxytelluride Bi{sub 2}O{sub 2}Te

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luu, Son D.N.; Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD; Vaqueiro, Paz, E-mail: p.vaqueiro@reading.ac.uk

2015-03-15

Bi{sub 2}O{sub 2}Te was synthesised from a stoichiometric mixture of Bi, Bi{sub 2}O{sub 3} and Te by a solid state reaction. Analysis of powder X-ray diffraction data indicates that this material crystallises in the anti-ThCr{sub 2}Si{sub 2} structure type (space group I4/mmm), with lattice parameters a=3.98025(4) and c=12.70391(16) Å. The electrical and thermal transport properties of Bi{sub 2}O{sub 2}Te were investigated as a function of temperature over the temperature range 300≤T (K)≤665. These measurements indicate that Bi{sub 2}O{sub 2}Te is an n-type semiconductor, with a band gap of 0.23 eV. The thermal conductivity of Bi{sub 2}O{sub 2}Te is remarkably lowmore » for a crystalline material, with a value of only 0.91 W m{sup −1} K{sup −1} at room temperature. - Graphical abstract: Bi{sub 2}O{sub 2}Te, which crystallises in the anti-ThCr{sub 2}Si{sub 2} structure type, is an n-type semiconductor with a remarkably low thermal conductivity. - Highlights: • Bi{sub 2}O{sub 2}Te crystallises in the anti-ThCr{sub 2}Si{sub 2} structure type. • Bi{sub 2}O{sub 2}Te is an n-type semiconductor, with a band gap of 0.23 eV. • The thermal conductivity of Bi{sub 2}O{sub 2}Te approaches values found for amorphous solids. • The thermoelectric figure of merit of undoped Bi{sub 2}O{sub 2}Te reaches 0.13 at 573 K.« less

Sequential extraction of chromium, molybdenum, and vanadium in basic oxygen furnace slags.

PubMed

Spanka, Marina; Mansfeldt, Tim; Bialucha, Ruth

2018-06-02

Basic oxygen furnace slags (BOS) are by-products of basic oxygen steel production. Whereas the solubility of some elements from these slags has been well investigated, information about the mineralogy and related leaching, i.e., availability of the environmentally relevant elements chromium (Cr), molybdenum (Mo), and vanadium (V), is still lacking. The aim of this study was to investigate these issues with a modified, four-fraction-based, sequential extraction procedure (F1-F4), combined with X-ray diffraction, of two BOS. Extractants with increasing strength were used (F1 demineralized water, F2 CH 3 COOH + HCl, F3 Na 2 EDTA + NH 2 OH·HCl, and F4 HF + HNO 3 + H 2 O 2 ), and after each fraction, X-ray diffraction was performed. The recovery of Cr was moderate (66.5%) for one BOS, but significantly better (100.2%) for the other one. High recoveries were achieved for the other elements (Mo, 100.8-107.9% and V, 112.6-87.0%), indicating that the sequential extraction procedure was reliable when adapted to BOS. The results showed that Cr and Mo primarily occurred in F4, representing rather immobile elements under natural conditions, which were strongly bound into/onto Fe minerals (srebrodolskite, magnetite, hematite, or wustite). In contrast, V was more mobile with proportional higher findings in F2 and F3, and the X-ray diffraction results reveal that V was not solely bound into Ca minerals (larnite, hatrurite, kirschsteinite, and calcite), but also bound to Fe minerals. The results indicated that the total amount of recovery was a poor indicator of the availability of elements and did not correspond to the leaching of elements from BOS.

Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.

PubMed

Guerrieri, Elena; Mallareddy, Jayapal Reddy; Tóth, Géza; Schmidhammer, Helmut; Spetea, Mariana

2015-03-18

Herein we report the radiolabeling and pharmacological investigation of a novel radioligand, the N-cyclobutylmethyl substituted diphenethylamine [(3)H]HS665, designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders). HS665 was prepared in tritium-labeled form by a dehalotritiated method resulting in a specific activity of 30.65 Ci/mmol. Radioligand binding studies were performed to establish binding properties of [(3)H]HS665 to the recombinant human KOP receptor in membranes from Chinese hamster ovary cells stably expressing human KOP receptors (CHOhKOP) and to the native neuronal KOP receptor in guinea pig brain membranes. Binding of [(3)H]HS665 was specific and saturable in both tissue preparations. A single population of high affinity binding sites was labeled by [(3)H]HS665 in membranes from CHOhKOP cells and guinea pig brain with similar equilibrium dissociation constants, Kd, 0.45 and 0.64 nM, respectively. Average receptor density of [(3)H]HS665 recognition sites were 5564 and 154 fmol/mg protein in CHOhKOP cells and guinea pig brain, respectively. This study shows that the new radioligand distinguishes and labels KOP receptors specifically in neuronal and cellular systems expressing KOP receptors, making this molecule a valuable tool in probing structural and functional mechanisms governing ligand-KOP receptor interactions in both a recombinant and native in vitro setting.

Bacterial Cr(VI) reduction concurrently improves sunflower (Helianthus Annuus L.) growth.

PubMed

Faisal, Muhammad; Hasnain, Shahida

2005-07-01

Four Cr(VI)-reducing bacterial strains (Ochrobactrum intermedium, CrT-2, CrT-3 and CrT-4) previously isolated from chromium-contaminated sites were inoculated on to seeds of sunflower (Helianthus annuus var SF-187), which were germinated and grown along with non-inoculated controls with chromate salts (300 microg CrCl3 or K2CrO4 ml(-1)). Severe reduction (20%) in seed germination was observed in Cr(VI) stress. Plant height decreased (36%) with Cr(VI) when compared with chromium-free control, while O. intermedium inoculation resulted a 20% increment in this parameter as compared to non-inoculated chromium-free control. CrT-3 inoculation resulted a 69% increment in auxin content as compared to non-inoculated control. O. intermedium caused 30% decrease in chromium uptake in sunflower plant roots under Cr(VI) stress as compared to chromium-free control plants.

ePrescribing: Reducing Costs Through In-Class Therapeutic Interchange

PubMed Central

Stenner, Shane P.; Chakravarthy, Rohini; Johnson, Kevin B.; Miller, William L.; Olson, Julie; Wickizer, Marleen; Johnson, Nate N.; Ohmer, Rick; Uskavitch, David R.; Bernard, Gordon R.; Neal, Erin B.

2016-01-01

Summary Introduction Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Methods Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. Results For all medication classes, significant improvements were demonstrated – the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. Conclusion A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan – $17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates. PMID:27966005

Gonadotropin-releasing Hormone Agonists, Orchiectomy, and Risk of Cardiovascular Disease: Semi-ecologic, Nationwide, Population-based Study.

PubMed

Thomsen, Frederik Birkebæk; Sandin, Fredrik; Garmo, Hans; Lissbrant, Ingela Franck; Ahlgren, Göran; Van Hemelrijck, Mieke; Adolfsson, Jan; Robinson, David; Stattin, Pär

2017-12-01

In observational studies, men with prostate cancer treated with gonadotropin-releasing hormone (GnRH) agonists had a higher risk of cardiovascular disease (CVD) compared to men who had undergone orchiectomy. However, selection bias may have influenced the difference in risk. To investigate the association of type of androgen deprivation therapy (ADT) with risk of CVD while minimising selection bias. Semi-ecologic study of 6556 men who received GnRH agonists and 3330 men who underwent orchiectomy as primary treatment during 1992-1999 in the Prostate Cancer Database Sweden 3.0. We measured the proportion of men who received GnRH agonists as primary treatment in 580 experimental units defined by healthcare provider, diagnostic time period, and age at diagnosis. Incident or fatal CVD events in units with high and units with low use of GnRH agonists were compared. Net and crude probabilities were also analysed. The risk of CVD was similar between units with the highest and units with the lowest proportion of GnRH agonist use (relative risk 1.01, 95% confidence interval [CI] 0.93-1.11). Accordingly, there was no difference in the net probability of CVD after GnRH agonist compared to orchiectomy (hazard ratio 1.02, 95% CI 0.96-1.09). The 10-yr crude probability of CVD was 0.56 (95% CI 0.55-0.57) for men on GnRH agonists and 0.52 (95% CI 0.50-0.54) for men treated with orchiectomy. The main limitation was the nonrandom allocation to treatment, with younger men with lower comorbidity and less advanced cancer more likely to receive GnRH agonists. Our data do not support previous observations that GnRH agonists increase the risk of CVD in comparison to orchiectomy. We found a similar risk of cardiovascular disease between medical and surgical treatment as androgen deprivation therapy for prostate cancer. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

FAST CHOPPER BUILDING, TRA665. CAMERA FACING NORTH. NOTE BRICKEDIN WINDOW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FAST CHOPPER BUILDING, TRA-665. CAMERA FACING NORTH. NOTE BRICKED-IN WINDOW ON RIGHT SIDE (BELOW PAINTED NUMERALS "665"). SLIDING METAL DOOR ON COVERED RAIL AT UPPER LEVEL. SHELTERED ENTRANCE TO STEEL SHIELDING DOOR. DOOR INTO MTR SERVICE BUILDING, TRA-635, STANDS OPEN. MTR BEHIND CHOPPER BUILDING. INL NEGATIVE NO. HD42-1. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized Clinical Efficacy Trial

PubMed Central

Blumenthal, James A.; Sherwood, Andrew; Smith, Patrick J.; Watkins, Lana; Mabe, Stephanie; Kraus, William E.; Ingle, Krista; Miller, Paula; Hinderliter, Alan

2016-01-01

Background Cardiac rehabilitation (CR) is the standard of care for patients with coronary heart disease (CHD). Despite considerable epidemiologic evidence that high stress is associated with worse health outcomes, stress management training (SMT) is not included routinely as a component of CR. Methods and Results 151 outpatients with CHD aged 36 to 84 years were randomized to 12-weeks of comprehensive CR or comprehensive CR combined with SMT (CR+SMT), with assessments of stress and CHD biomarkers obtained before and after treatment. A matched sample of CR-eligible patients who did not receive CR comprised a No-CR comparison group. All participants were followed for up to 5.3 years (median = 3.2 years) for clinical events. Patients randomized to CR+SMT exhibited greater reductions in composite stress levels compared with those randomized to CR alone (P = 0.022), an effect that was driven primarily by improvements in anxiety, distress, and perceived stress. Both CR groups achieved significant, and comparable, improvements in CHD biomarkers. Participants in the CR+SMT group exhibited lower rates of clinical events compared with CR alone (18% vs. 33%, HR = 0.49 [0.25, 0.95], P = 0.035) and both CR groups had lower event rates compared to the No-CR group (47%, HR = 0.44 [0.27, 0.71], P < .001). Conclusions CR enhanced by SMT produced significant reductions in stress and greater improvements in medical outcomes compared with standard CR. Our findings indicate that SMT may provide incremental benefit when combined with comprehensive CR and suggest that SMT should be incorporated routinely into CR. Clinical Trial Registration Information www.Clinicaltrials.gov. Identifier: NCT00981253. PMID:27045127

Prospective cohort study of impulse control disorders in Parkinson's disease.

PubMed

Bastiaens, Jesse; Dorfman, Benjamin J; Christos, Paul J; Nirenberg, Melissa J

2013-03-01

Impulse control disorders (ICDs) are potentially serious side effects of dopamine agonist therapy in Parkinson's disease (PD), but prospective data are lacking about their incidence, time course, and risk factors. This work was a 4-year, prospective cohort study of outpatients with PD and no previous ICDs (N = 164). All subjects treated with a dopamine agonist during the study were followed longitudinally for new-onset ICDs. Baseline characteristics were compared in groups with (ICD+) and without (ICD-) subsequent ICDs. Forty-six subjects were treated with a dopamine agonist, including 25 who were newly treated and 21 who received ongoing dopamine agonist therapy. Of these 46 subjects, 18 (39.1%) developed new-onset ICDs. The timing of ICD onset varied from 3.0 to 114.0 months (median, 23.0) after initiation of dopamine agonist therapy. Baseline demographic characteristics were similar in ICD+ and ICD- groups. At baseline, ICD+ subjects had a greater prevalence of motor complications (61.1% versus 25.0%; P = 0.01) than ICD- subjects, despite comparable total dopaminergic medication usage in both groups (median, 150.0 versus 150.0 levodopa equivalents; P = 0.61). Compared with ICD- subjects, ICD+ subjects had a greater baseline prevalence of caffeine use (100% versus 66.7%; P = 0.007) and higher lifetime prevalence of cigarette smoking (44.4% versus 14.3%; P = 0.04). Peak dopamine agonist doses were higher in ICD+ than ICD- subjects (median 300.0 versus 165.0 L-dopa equivalents; P = 0.03), but cumulative dopamine agonist exposure was similar in both groups. In summary, the timing of new-onset ICDs in PD is highly variable. Risk factors include cigarette smoking, caffeine use, motor complications, and higher peak dopamine agonist dosage. Copyright © 2013 Movement Disorders Society.

Use of a GnRH antagonist in controlled ovarian hyperstimulation for assisted conception in women with polycystic ovary disease: a randomized, prospective, pilot study.

PubMed

Bahçeci, Mustafa; Ulug, Ulun; Ben-Shlomo, Izhar; Erden, Halit Firat; Akman, Mehmet Ali

2005-02-01

To compare the outcome of using gonadotropin-releasing hormone (GnRH) antagonists versus agonists in women with polycystic ovary disease (PCOD) who underwent controlled ovarian hyperstimulation (COH) for assisted reproductive techniques (ART). A total of 129 patients with PCOD were randomly allocated to undergo COH with a GnRH antagonist (59 patients) and GnRH agonist (leuprolide acetate) (70 patients) to prevent a premature luteinizing hormone (LH) surge. Assisted fertilization following oocyte retrieval and embryo transfer was performed. None of the cycles were cancelled due to a premature LH surge. There was no significant difference between the antagonist and agonist arms in the number of gonadotropin ampules consumed per cycle. However, in the antagonist arm a shorter duration of ovarian stimulation was recorded as compared to the agonist arm. Although similar numbers of oocytes was retrieved from both groups of patients, the quality of the oocytes, as measured by metaphase 2/total oocyte ratio, was lower in the antagonist arm as compared to the agonist arm. Pregnancy rates were 57.6% and 58.5% in the antagonist and agonist arms, respectively (p > 0.05). Implantation rates were not different (34.0% and 34.6%, respectively). The frequency of ovarian hyperstimulation syndrome also did not differ between the treatment groups (5% and 7.1%, respectively). The size of our study, on a specific subgroup of patients, does not allow a reliable conclusion regarding ART outcomefollowing the use of a GnRH antagonist versus agonist. Nevertheless, the protocol with the antagonist gave results that were as good as those of the protocol with the agonist in this PCOD patient population.

Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brone, Bert; Peeters, Pieter J.; Marrannes, Roger

2008-09-01

The TRPA1 channel is activated by a number of pungent chemicals, such as allylisothiocyanate, present in mustard oil and thiosulfinates present in garlic. Most of the known activating compounds contain reactive, electrophilic chemical groups, reacting with cysteine residues in the active site of the TRPA1 channel. This covalent modification results in activation of the channel and has been shown to be reversible for several ligands. Commonly used tear gasses CN, CR and CS are also pungent chemicals, and in this study we show that they are extremely potent and selective activators of the human TRPA1 receptor. To our knowledge, thesemore » are the most potent TRPA1 agonists known to date. The identification of the molecular target for these tear gasses may open up possibilities to alleviate the effects of tear gasses via treatment with TRPA1 antagonists. In addition these results may contribute to the basic knowledge of the TRPA1 channel that is gaining importance as a pharmacological target.« less

SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism

DOE PAGES

van Marrewijk, Laura M.; Polyak, Steven W.; Hijnen, Marcel; ...

2015-11-18

Here, synthetic full agonists of PPARγ have been prescribed for the treatment of diabetes due to their ability to regulate glucose homeostasis and insulin sensitization. While the use of full agonists of PPARγ has been hampered due to severe side effects, partial agonists have shown promise due to their decreased incidence of such side effects in preclinical models. No kinetic information has been forthcoming in regard to the mechanism of full versus partial agonism of PPARγ to date. In this paper, we describe the discovery of a partial agonist, SR2067. A co-crystal structure obtained at 2.2 Å resolution demonstrates thatmore » interactions with the β-sheet are driven exclusively via hydrophobic interactions mediated through a naphthalene group, an observation that is unique from other partial agonists. Finally, surface plasmon resonance revealed that SR2067 binds to the receptor with higher affinity (K D = 513 nM) as compared to that of full agonist rosiglitazone, yet it has a much slower off rate compared to that of rosiglitazone.« less

50 CFR 665.641 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) means the EEZ around Palmyra Atoll, Kingman Reef, Jarvis Island, Baker Island, Howland Island, Johnston Atoll, and Wake Island. PRIA crustacean fishing permit means the permit required by § 665.642 to use a...

50 CFR 665.641 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) means the EEZ around Palmyra Atoll, Kingman Reef, Jarvis Island, Baker Island, Howland Island, Johnston Atoll, and Wake Island. PRIA crustacean fishing permit means the permit required by § 665.642 to use a...

50 CFR 665.641 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) means the EEZ around Palmyra Atoll, Kingman Reef, Jarvis Island, Baker Island, Howland Island, Johnston Atoll, and Wake Island. PRIA crustacean fishing permit means the permit required by § 665.642 to use a...

Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.

PubMed

Mehmood, Malik Hassan; Gilani, Anwarul Hassan

2010-10-01

Dried fruits of Piper nigrum (black pepper) are commonly used in gastrointestinal disorders. The aim of this study was to rationalize the medicinal use of pepper and its principal alkaloid, piperine, in constipation and diarrhea using in vitro and in vivo assays. When tested in isolated guinea pig ileum, the crude extract of pepper (Pn.Cr) (1–10 mg/mL) and piperine (3–300 μM) caused a concentration-dependent and atropine-sensitive stimulant effect. In rabbit jejunum, Pn.Cr (0.01–3.0 mg/mL) and piperine (30–1,000 μM) relaxed spontaneous contractions, similar to loperamide and nifedipine. The relaxant effect of Pn.Cr and piperine was partially inhibited in the presence of naloxone (1 μM) similar to that of loperamide, suggesting the naloxone-sensitive effect in addition to the Ca(2+) channel blocking (CCB)-like activity, which was evident by its relaxant effect on K+ (80 mM)-induced contractions. The CCB activity was confirmed when pretreatment of the tissue with Pn.Cr (0.03–0.3 mg/mL) or piperine (10–100 μM) caused a rightward shift in the concentration–response curves of Ca(2+), similar to loperamide and nifedipine. In mice, Pn.Cr and piperine exhibited a partially atropine-sensitive laxative effect at lower doses, whereas at higher doses it caused antisecretory and antidiarrheal activities that were partially inhibited in mice pretreated with naloxone (1.5 mg/kg), similar to loperamide. This study illustrates the presence of spasmodic (cholinergic) and antispasmodic (opioid agonist and Ca(2+) antagonist) effects, thus providing the possible explanation for the medicinal use of pepper and piperine in gastrointestinal motility disorders.

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

PubMed Central

Valencia-Torres, Lourdes; Olarte-Sánchez, Cristian M; Lyons, David J; Georgescu, Teodora; Greenwald-Yarnell, Megan; Myers, Martin G; Bradshaw, Christopher M; Heisler, Lora K

2017-01-01

Obesity is primarily due to food intake in excess of the body's energetic requirements, intake that is not only associated with hunger but also the incentive value of food. The 5-hydroxytryptamine 2C receptor (5-HT2CR) is a target for the treatment of human obesity. Mechanistically, 5-HT2CRs are positioned to influence both homeostatic feeding circuits within the hypothalamus and reward circuits within the ventral tegmental area (VTA). Here we investigated the role of 5-HT2CRs in incentive motivation using a mathematical model of progressive ratio (PR) responding in mice. We found that the 5-HT2CR agonist lorcaserin significantly reduced both ad libitum chow intake and PR responding for chocolate pellets and increased c-fos expression in VTA 5-HT2CR expressing γ-aminobutyric acid (GABA) neurons, but not 5-HT2CR expressing dopamine (DA) neurons. We next adopted a chemogenetic approach using a 5-HT2CRCRE line to clarify the function of subset of 5-HT2C receptor expressing VTA neurons in the modulation of appetite and food-motivated behavior. Activation of VTA 5-HT2C receptor expressing neurons significantly reduced ad libitum chow intake, operant responding for chocolate pellets, and the incentive value of food. In contrast, chemogenetic inhibition of VTA 5-HT2C receptor expressing neurons had no effect on the feeding behavior. These results indicate that activation of the subpopulation of 5-HT2CR neurons within the VTA is sufficient to significantly reduce homeostatic feeding and effort-based intake of palatable food, and that this subset has an inhibitory role in motivational processes. These findings are relevant to the treatment of obesity. PMID:27882999

50 CFR 665.628 - Gear identification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 665.624 or that is otherwise established to be fishing for PRIA coral reef ecosystem MUS in the PRIA... officer. (2) Unattended surround nets or bait seine nets found deployed in the coral reef ecosystem...

50 CFR 665.628 - Gear identification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 665.624 or that is otherwise established to be fishing for PRIA coral reef ecosystem MUS in the PRIA... officer. (2) Unattended surround nets or bait seine nets found deployed in the coral reef ecosystem...

50 CFR 665.628 - Gear identification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 665.624 or that is otherwise established to be fishing for PRIA coral reef ecosystem MUS in the PRIA... officer. (2) Unattended surround nets or bait seine nets found deployed in the coral reef ecosystem...

50 CFR 665.628 - Gear identification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 665.624 or that is otherwise established to be fishing for PRIA coral reef ecosystem MUS in the PRIA... officer. (2) Unattended surround nets or bait seine nets found deployed in the coral reef ecosystem...

50 CFR 665.628 - Gear identification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 665.624 or that is otherwise established to be fishing for PRIA coral reef ecosystem MUS in the PRIA... officer. (2) Unattended surround nets or bait seine nets found deployed in the coral reef ecosystem...

32 CFR 37.665 - Must I require nonprofit participants to have periodic audits?

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Financial Matters § 37.665 Must I require nonprofit...

50 CFR 665.205 - Notification.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.205 Notification... operator may be contacted during the business day (8 a.m. to 5 p.m.) to indicate whether an observer will...

50 CFR 665.399 - Area restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Mariana Archipelago Fisheries § 665.399 Area restrictions. Anchoring by all fishing vessels over 50 ft (15.25 m) LOA is prohibited in the U.S...

Spectroscopic study of synthetic hydrothermal Fe3+-bearing beryl

NASA Astrophysics Data System (ADS)

Taran, Michail N.; Dyar, M. Darby; Khomenko, Vladimir M.

2017-12-01

A synthetic hydrothermal beryl Fe-4-51, investigated previously by Taran and Rossman (Am Miner 86:973-980, 2001), was additionally studied by microprobe, Mössbauer, optical absorption, Raman and IR spectroscopy. For comparison, polarized spectra of natural blue aquamarine and Cr3+, Fe3+-bearing alexandrite, both from Brazil, are also presented. Fe-4-51 is a nearly pure Fe3+-bearing beryl, with a homogeneous composition as shown by electron microprobe. Averaging over 22 points gives a formula of Be3.07(Al1.94,{Fe}_{{{0.07}}}^{{{3}+}} )Σ=2.01Si5.95O18, with Fe3+ replacing Al3+ in the octahedral site of the structure. The Mössbauer spectrum is dominated by a broad disordered pattern with beryl-suitable parameters; for Fe2+, IS = 1.21 mm/s, QS = 2.71 mm/s, area ≈ 5% and for Fe3+, IS = 0.34 mm/s, QS = 0.71 mm/s, and area ≈ 67%—are distinguished overlying a broad disordered continuum. The optical absorption spectrum is typical of octahedral Fe3+. From it, the crystal field strength Dq is derived as 1520 cm-1 and the values of Racah parameters of interelectronic repulsion B and C are found to be 665 and 3415 cm-1, respectively. This rather low B value, compared with that of a free Fe3+ ion, 814 cm-1, suggests a comparatively high degree of covalency in the octahedral Fe3+-O bond. Infrared spectra show the presence of channel H2O of both I and II structural type in comparable quantities, about 0.5 and 1 mass%, respectively. Raman data show the expected five bands in the energy range from 300 to 1200 cm-1.