Science.gov

Sample records for agreement included development

  1. 2 CFR 200.201 - Use of grant agreements (including fixed amount awards), cooperative agreements, and contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Use of grant agreements (including fixed... (including fixed amount awards), cooperative agreements, and contracts. (a) The Federal awarding agency or... Agreement Act (31 U.S.C. 6301-08). (b) Fixed Amount Awards. In addition to the options described...

  2. 42 CFR 137.329 - What environmental considerations must be included in the construction project agreement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SELF-GOVERNANCE Construction Project Assumption Process § 137.329 What environmental considerations must be included in the construction project agreement? The construction project agreement must include... in the construction project agreement? 137.329 Section 137.329 Public Health PUBLIC HEALTH...

  3. Development and Validation of the Sexual Agreement Investment Scale

    PubMed Central

    Neilands, Torsten B.; Chakravarty, Deepalika; Darbes, Lynae A.; Beougher, Sean C.; Hoff, Colleen C.

    2009-01-01

    Introduction Sexual agreements are ubiquitous among gay men. Lower levels of investment in these agreements may be associated with breaking them or engaging in risky sexual behavior. We developed a scale to measure agreement investment levels among gay men. Methods We analyzed qualitative data from 78 gay men in committed relationships to inform item development, followed by quantitative analyses of two larger samples (n=380; n=1001) to assess construct, convergent, and discriminant validity. Results The Sexual Agreement Investment Scale (SAIS) is a psychometrically sound measure of level of the investment in sexual agreements among gay men in relationships. Men with higher agreement investment were less likely to break agreements and to engage in unprotected intercourse with outside partners. Discussion The SAIS can be used to measure investment in sexual agreements and its impact on sexual behavior in a wide variety of settings, including research on relationships, sexuality, couples therapy, and HIV-prevention. PMID:19396645

  4. 42 CFR 137.329 - What environmental considerations must be included in the construction project agreement?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... in the construction project agreement? 137.329 Section 137.329 Public Health PUBLIC HEALTH SERVICE... SELF-GOVERNANCE Construction Project Assumption Process § 137.329 What environmental considerations must be included in the construction project agreement? The construction project agreement must...

  5. Cooperative research and development agreements at METC

    SciTech Connect

    Ludlow, J.C.; Jarr, L.A.; Anderson, R.J.

    1995-06-01

    The Federal Technology Transfer Act of 1986 (P.L. 99-502) provided a new mechanism for joint research between private parties and the Morgantown Energy Technology Center (METC). Joint projects under this law are called Cooperative Research And Development Agreements (CRADAs) and are simply agreements between METC and the private sector to work together on a mutually beneficial project. Of primary interest to METC is the development and deployment of: (1) clean, efficient power generation technologies, (2) technologies for the characterization and exploitation of the Nation`s natural gas resource, and (3) environmental remediation technologies.

  6. 42 CFR 137.327 - May multiple projects be included in a single construction project agreement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-GOVERNANCE Construction Project Assumption Process § 137.327 May multiple projects be included in a single construction project agreement? Yes, a Self-Governance Tribe may include multiple projects in a single... construction project agreement? 137.327 Section 137.327 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT...

  7. 42 CFR 137.327 - May multiple projects be included in a single construction project agreement?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... construction project agreement? 137.327 Section 137.327 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF...-GOVERNANCE Construction Project Assumption Process § 137.327 May multiple projects be included in a single construction project agreement? Yes, a Self-Governance Tribe may include multiple projects in a...

  8. 42 CFR 137.335 - What costs may be included in the budget for a construction agreement?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Construction Project Assumption Process § 137.335 What costs may be included in the budget for a construction... project agreement that will be used. (b) Regardless of whether a construction project agreement is fixed...) Construction project proposal preparation; (2) Conducting community meetings to develop project documents;......

  9. 42 CFR 137.335 - What costs may be included in the budget for a construction agreement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... provide services, to include construction management services; (9) Project site development; (10) Project... construction agreement? 137.335 Section 137.335 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... Construction Project Assumption Process § 137.335 What costs may be included in the budget for a...

  10. 42 CFR 137.335 - What costs may be included in the budget for a construction agreement?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... provide services, to include construction management services; (9) Project site development; (10) Project... construction agreement? 137.335 Section 137.335 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... Construction Project Assumption Process § 137.335 What costs may be included in the budget for a...

  11. 42 CFR 137.335 - What costs may be included in the budget for a construction agreement?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... provide services, to include construction management services; (9) Project site development; (10) Project... construction agreement? 137.335 Section 137.335 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... Construction Project Assumption Process § 137.335 What costs may be included in the budget for a...

  12. 42 CFR 137.335 - What costs may be included in the budget for a construction agreement?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... provide services, to include construction management services; (9) Project site development; (10) Project... construction agreement? 137.335 Section 137.335 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... Construction Project Assumption Process § 137.335 What costs may be included in the budget for a...

  13. 75 FR 38543 - Klamath Hydroelectric Settlement Agreement, Including Secretarial Determination on Whether To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ...@usbr.gov . Correction In the Federal Register of June 14, 2010, (75 FR 33634), in column 2, correct the... Bureau of Reclamation Klamath Hydroelectric Settlement Agreement, Including Secretarial Determination on... locations. Dated: June 23, 2010. Dennis Lynch, Program Manager, Klamath Basin Secretarial...

  14. Developing country finance in a post-2020 global climate agreement

    NASA Astrophysics Data System (ADS)

    Hannam, Phillip M.; Liao, Zhenliang; Davis, Steven J.; Oppenheimer, Michael

    2015-11-01

    A central task for negotiators of the post-2020 global climate agreement is to construct a finance regime that supports low-carbon development in developing economies. As power sector investments between developing countries grow, the climate finance regime should incentivize the decarbonization of these major sources of finance by integrating them as a complement to the commitments of developed nations. The emergence of the Asian Infrastructure Investment Bank, South-South Cooperation Fund and other nascent institutions reveal the fissures that exist in rules and norms surrounding international finance in the power sector. Structuring the climate agreement in Paris to credit qualified finance from the developing world could have several advantages, including: (1) encouraging low-carbon cooperation between developing countries; (2) incentivizing emerging investors to prefer low-carbon investments; and (3) enabling more cost-effective attainment of national and global climate objectives. Failure to coordinate on standards now could hinder low-carbon development in the decades to come.

  15. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... programs in a construction project agreement or in a funding agreement? 137.275 Section 137.275 Public...-Governance Tribes include IHS construction programs in a construction project agreement or in a funding agreement? Yes, Self-Governance Tribes may choose to assume construction programs in a construction...

  16. Co-Development Agreements | NCI Technology Transfer Center | TTC

    Cancer.gov

    The National Cancer Institute's TTC uses three different co-development agreements to help industry and academia interact and partner with National Institutes of Health laboratories and scientists to support technology development activities.

  17. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  18. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... services and construction management services. Construction Definitions ... 42 Public Health 1 2014-10-01 2014-10-01 false May Self-Governance Tribes include IHS construction programs in a construction project agreement or in a funding agreement? 137.275 Section 137.275...

  19. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... services and construction management services. Construction Definitions ... 42 Public Health 1 2013-10-01 2013-10-01 false May Self-Governance Tribes include IHS construction programs in a construction project agreement or in a funding agreement? 137.275 Section 137.275...

  20. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... services and construction management services. Construction Definitions ... 42 Public Health 1 2012-10-01 2012-10-01 false May Self-Governance Tribes include IHS construction programs in a construction project agreement or in a funding agreement? 137.275 Section 137.275...

  1. 77 FR 47880 - U.S.-Trans-Pacific Partnership Free Trade Agreement Including Canada and Mexico: Advice on the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... COMMISSION U.S.-Trans-Pacific Partnership Free Trade Agreement Including Canada and Mexico: Advice on the... instituted investigation nos. TA-131-036 and TA-2104-028, U.S.-Trans-Pacific Partnership Free Trade Agreement... joined the negotiations, known as the Trans-Pacific Partnership (TPP) negotiations, and requested...

  2. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  3. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  4. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  5. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  6. Reduction of Conflicts in Mining Development Using "Good Neighbor Agreements"

    NASA Astrophysics Data System (ADS)

    Masaitis, A.

    2013-05-01

    New environmental and social challenges for the mining industry in both developed and developing countries show the obvious need to implement "responsible" mining practices that include improved community involvement. Good Neighbor Agreements (GNA's) are a relatively new mechanism for improving communication and trust between a mining company and the community. The focus of a GNA will be to provide a written and enforceable agreement, negotiated between the concerned public and the respective mining company to respond to concerns from the public, and also provide a mechanism for conflict resolution, when there is mutual benefit to maintain a working relationship. Development of GNA's, a recently evolving process that promotes environmentally sound relationships between mines and the surrounding communities. Modify and apply the resulting GNA formulas to the developing countries and countries with transitional economies. This is particularly important for countries that have poorly functioning regulatory systems that cannot guarantee a healthy and safe environment for the communities. The fundamental questions addressed by this research. 1. This is a three-year research project started in August 2012 at the University of Nevada, Reno (UNR) to develop a Good Neighbor Agreements standards as well as to investigate the details of mine development. 2. Identify spheres of possible cooperation between mining companies, government organizations, and the Non-Governmental Organizations (NGO's). Use this cooperation to develop international standards for the GNA, to promote exchange of environmental information, and exchange of successful environmental, health, and safety practices between mining operations from different countries. Discussion: The Good Neighbor Agreement currently evolving will address the following: 1. Provide an economically viable mechanism for developing a partnership between mining operations and the local communities that will increase mining industry

  7. Guidebook to Developing a Collaborative Partnership Written Agreement.

    ERIC Educational Resources Information Center

    Illinois State Dept. of Human Services, East St. Louis. Head Start State Collaboration Office.

    As programs serving young children and their families increasingly work together to provide services, written agreements or contracts become more important in clarifying the roles of each partner in the collaboration. This document provides guidance in developing written agreements between Head Start programs and other programs or agencies. The…

  8. 78 FR 28623 - U.S.-Trans-Pacific Partnership Free Trade Agreement Including Japan: Advice on the Probable...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... application of a U.S. nontariff barrier would result in different advice with respect to the effect of the... Including Japan: Advice on the Probable Economic Effect of Providing Duty-Free Treatment for Imports AGENCY...-Pacific Partnership Free Trade Agreement Including Japan: Advice on the Probable Economic Effect...

  9. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false May Self-Governance Tribes include IHS construction... OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Purpose and Scope § 137.275 May Self-Governance Tribes include IHS construction programs in a construction project agreement or in a...

  10. 36 CFR 79.8 - Terms and conditions to include in contracts, memoranda and agreements for curatorial services.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Terms and conditions to include in contracts, memoranda and agreements for curatorial services. 79.8 Section 79.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CURATION OF FEDERALLY-OWNED AND ADMINISTERED ARCHAEOLOGICAL COLLECTIONS §...

  11. 41 CFR 102-33.290 - What other disclaimers must we include in our exchange/sale agreements for aircraft?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What other disclaimers must we include in our exchange/sale agreements for aircraft? 102-33.290 Section 102-33.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY...

  12. 41 CFR 102-33.290 - What other disclaimers must we include in our exchange/sale agreements for aircraft?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What other disclaimers must we include in our exchange/sale agreements for aircraft? 102-33.290 Section 102-33.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY...

  13. 43 CFR 3137.28 - What oil and gas resources of committed tracts does the unit agreement include?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What oil and gas resources of committed tracts does the unit agreement include? 3137.28 Section 3137.28 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING:...

  14. FY2011 Progress Report: Agreement 8697 - NOx Sensor Development

    SciTech Connect

    Woo, L Y; Glass, R S

    2011-11-01

    different concentration regimes obtained from bench-level laboratory evaluation were used to adjust the sensor signal in dynamometer testing. Both NO{sub x} and O{sub 2} exhibited non-linear responses over the concentration regimes examined (0-100 ppm for NO{sub x} and 4-7% for O{sub 2}). Adjusted sensor signals had better agreement with both a commercial NO{sub x} sensor and FTIR measurements. However, the lack of complete agreement indicated that it was not possible to completely account for the nonlinear sensor behavior in certain concentration regimes. The agreement at lower NO{sub x} levels (less than 20 ppm) was better than at higher levels (50-100 ppm). Other progress in FY2011 included dynamometer testing of sensors with imbedded heaters and protective housings that were mounted directly into the exhaust manifold. Advanced testing protocols were used to evaluate the sensors. These experiments confirmed the potential for sensor robustness and durability. Advanced material processing methods appropriate for mass manufacturing, such as sputtering, are also being evaluated. A major milestone for this past year was the licensing of the LLNL NO{sub x} sensor technology to EmiSense Technologies, LLC. EmiSense has extensive experience and resources for the development of emission control sensors. A CRADA is in development that will allow LLNL to work in partnership with EmiSense to bring the LLNL NO{sub x} sensor technology to commercialization. Ford Motor Company is also a partner in this effort.

  15. Including Rural Districts in Inclusive Staff Development.

    ERIC Educational Resources Information Center

    Pfluger, Loretta; Hendricks, Jenny

    Teaching students who receive special education services in integrated settings requires intensive staff development and on-going training. Region 16 Education Service Center in the Texas panhandle serves 65 rural school districts covering 25,000 square miles and 80,000 students. In 1996, with direction and funding from the state legislature,…

  16. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be included in an agreement between an EN and a State VR agency? The agreement between an EN and a State...

  17. Development of a multi-party cooperative agreement at a Formerly Used Defense Site

    SciTech Connect

    Bilington, T.L.; Snowdon, J.P.; Mitchell, J.

    1994-12-31

    This paper presents a case study of the development of a multiple party cooperative agreement for a Formerly Used Defense Site (FUDS). The FUDS is located in the California Central Valley and was used as an Army Air Corps facility during World War II. Ground water contamination has been found in nearby public drinking water supply wells and the extent of contamination is currently being investigated. This paper will discuss various perspectives on the Cooperative Agreement. Those perspectives will include that of the California Department of Toxic Substances Control (Department), the lead state regulatory agency; the US Army Corps of Engineers Omaha District (USACE-Omaha), responsible for the Department of Defense (DOD) FUDS program for this site; and the City of Fresno, the current landowner. Further, this paper will discuss the site history, the regulatory history, the current status of the agreement, the current status of the site investigation, and plans for future activities at the site. The key issues of the Cooperative Agreement will also be discussed. Those key issues include: (1) the main points of contention between the various parties to the Cooperative Agreement; (2) problems encountered during the development of the Cooperative Agreement; and (3) how those points or problems were resolved. Finally, this paper summarizes the lessons learned with a brief retrospective of the parties` involvement in the process.

  18. 76 FR 78290 - Cooperative Research and Development Agreement: Usage of Biodiesel Fuel Blends Within Marine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Register (73 FR 3316). Cooperative Research and Development Agreements Cooperative Research and Development... SECURITY Coast Guard Cooperative Research and Development Agreement: Usage of Biodiesel Fuel Blends Within... technology enhancements, performance, costs, and other issues associated with using biodiesel fuel blends...

  19. European Union's public fishing access agreements in developing countries.

    PubMed

    Le Manach, Frédéric; Chaboud, Christian; Copeland, Duncan; Cury, Philippe; Gascuel, Didier; Kleisner, Kristin M; Standing, André; Sumaila, U Rashid; Zeller, Dirk; Pauly, Daniel

    2013-01-01

    The imperative to increase seafood supply while dealing with its overfished local stocks has pushed the European Union (EU) and its Member States to fish in the Exclusive Economic Zones of other countries through various types of fishing agreements for decades. Although European public fishing agreements are commented on regularly and considered to be transparent, this is the first global and historical study on the fee regime that governs them. We find that the EU has subsidized these agreements at an average of 75% of their cost (financial contribution agreed upon in the agreements), while private European business interests paid the equivalent of 1.5% of the value of the fish that was eventually landed. This raises questions of fisheries benefit-sharing and resource-use equity that the EU has the potential to address during the nearly completed reform of its Common Fisheries Policy. PMID:24312191

  20. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should...

  1. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should...

  2. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should...

  3. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should...

  4. 25 CFR 170.462 - When may a self-determination contract or self-governance agreement include PS&E review and...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false When may a self-determination contract or self-governance... Estimates § 170.462 When may a self-determination contract or self-governance agreement include PS&E review... and approve PS&E packages under a self-determination contract or self-governance agreement if...

  5. 25 CFR 170.462 - When may a self-determination contract or self-governance agreement include PS&E review and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When may a self-determination contract or self-governance... Estimates § 170.462 When may a self-determination contract or self-governance agreement include PS&E review... and approve PS&E packages under a self-determination contract or self-governance agreement if...

  6. 25 CFR 170.462 - When may a self-determination contract or self-governance agreement include PS&E review and...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When may a self-determination contract or self-governance... Estimates § 170.462 When may a self-determination contract or self-governance agreement include PS&E review... and approve PS&E packages under a self-determination contract or self-governance agreement if...

  7. 25 CFR 170.462 - When may a self-determination contract or self-governance agreement include PS&E review and...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true When may a self-determination contract or self-governance... Estimates § 170.462 When may a self-determination contract or self-governance agreement include PS&E review... and approve PS&E packages under a self-determination contract or self-governance agreement if...

  8. 25 CFR 170.462 - When may a self-determination contract or self-governance agreement include PS&E review and...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false When may a self-determination contract or self-governance... Estimates § 170.462 When may a self-determination contract or self-governance agreement include PS&E review... and approve PS&E packages under a self-determination contract or self-governance agreement if...

  9. 43 CFR 3137.40 - What initial development obligations must I define in a unit agreement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... I define in a unit agreement? 3137.40 Section 3137.40 Public Lands: Interior Regulations Relating to... Reserve-Alaska Development § 3137.40 What initial development obligations must I define in a unit agreement? Your unit agreement must define— (a) The number of wells you anticipate will be necessary...

  10. Assessing implementation mechanisms for an international agreement on research and development for health products.

    PubMed

    Hoffman, Steven J; Røttingen, John-Arne

    2012-11-01

    The Member States of the World Health Organization (WHO) are currently debating the substance and form of an international agreement to improve the financing and coordination of research and development (R&D) for health products that meet the needs of developing countries. In addition to considering the content of any possible legal or political agreement, Member States may find it helpful to reflect on the full range of implementation mechanisms available to bring any agreement into effect. These include mechanisms for states to make commitments, administer activities, manage financial contributions, make subsequent decisions, monitor each other's performance and promote compliance. States can make binding or non-binding commitments through conventions, contracts, declarations or institutional reforms. States can administer activities to implement their agreements through international organizations, sub-agencies, joint ventures or self-organizing processes. Finances can be managed through specialized multilateral funds, financial institutions, membership organizations or coordinated self-management. Decisions can be made through unanimity, consensus, equal voting, modified voting or delegation. Oversight can be provided by peer review, expert review, self-reports or civil society. Together, states should select their preferred options across categories of implementation mechanisms, each of which has advantages and disadvantages. The challenge lies in choosing the most effective combinations of mechanisms for supporting an international agreement (or set of agreements) that achieves collective aspirations in a way and at a cost that are both sustainable and acceptable to those involved. In making these decisions, WHO's Member States can benefit from years of experience with these different mechanisms in health and its related sectors. PMID:23226898

  11. Assessing implementation mechanisms for an international agreement on research and development for health products

    PubMed Central

    Røttingen, John-Arne

    2012-01-01

    Abstract The Member States of the World Health Organization (WHO) are currently debating the substance and form of an international agreement to improve the financing and coordination of research and development (R&D) for health products that meet the needs of developing countries. In addition to considering the content of any possible legal or political agreement, Member States may find it helpful to reflect on the full range of implementation mechanisms available to bring any agreement into effect. These include mechanisms for states to make commitments, administer activities, manage financial contributions, make subsequent decisions, monitor each other’s performance and promote compliance. States can make binding or non-binding commitments through conventions, contracts, declarations or institutional reforms. States can administer activities to implement their agreements through international organizations, sub-agencies, joint ventures or self-organizing processes. Finances can be managed through specialized multilateral funds, financial institutions, membership organizations or coordinated self-management. Decisions can be made through unanimity, consensus, equal voting, modified voting or delegation. Oversight can be provided by peer review, expert review, self-reports or civil society. Together, states should select their preferred options across categories of implementation mechanisms, each of which has advantages and disadvantages. The challenge lies in choosing the most effective combinations of mechanisms for supporting an international agreement (or set of agreements) that achieves collective aspirations in a way and at a cost that are both sustainable and acceptable to those involved. In making these decisions, WHO’s Member States can benefit from years of experience with these different mechanisms in health and its related sectors. PMID:23226898

  12. Development and implementation of the Good Neighbor Agreement (GNA) practice in the USA sustainable mining development.

    NASA Astrophysics Data System (ADS)

    Masaitis, Alexandra

    2014-05-01

    New economic, environmental and social challenges for the mining industry in the USA show the need to implement "responsible" mining practices that include improved community involvement. Conflicts which occur in the US territory and with US mining companies around the world are now common between the mining proponents, NGO's and communities. These conflicts can sometimes be alleviated by early development of modes of communication, and a formal discussion format that allows airing of concerns and potential resolution of problems. One of the methods that can formalize this process is to establish a Good Neighbor Agreement (GNA), which deals specifically with challenges in relationships between mining operations and the local communities. It is a new practice related to mining operations that are oriented toward social needs and concerns of local communities that arise during the normal life of a mine, which can achieve sustainable mining practices. The GNA project being currently developed at the University of Nevada, USA in cooperation with the Newmont Mining Corporation has a goal of creating an open company/community dialog that will help identify and address sociological and environmental concerns associated with mining. Discussion: The Good Neighbor Agreement currently evolving will address the following: 1. Identify spheres of possible cooperation between mining companies, government organizations, and NGO's. 2. Provide an economically viable mechanism for developing a partnership between mining operations and the local communities that will increase mining industry's accountability and provide higher levels of confidence for the community that a mine is operated in a safe and sustainable manner. Implementation of the GNA can help identify and evaluate conflict criteria in mining/community relationships; determine the status of concerns; determine the role and responsibilities of stakeholders; analyze problem resolution feasibility; maintain the community

  13. 77 FR 17095 - Solicitation for a Cooperative Agreement-Development of a Core Correctional Practices Curriculum

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--Development of a Core...: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement for a...

  14. A Best Practice for Developing Availability Guarantee Language in Photovoltaic (PV) O&M Agreements.

    SciTech Connect

    Klise, Geoffrey Taylor; Balfour, John

    2015-11-01

    This document outlines the foundation for developing language that can be utilized in an Equipment Availability Guarantee, typically included in an O&M services agreement between a PV system or plant owner and an O&M services provider, or operator. Many of the current PV O&M service agreement Availability Guarantees are based on contracts used for traditional power generation, which create challenges for owners and operators due to the variable nature of grid-tied photovoltaic generating technologies. This report documents language used in early PV availability guarantees and presents best practices and equations that can be used to more openly communicate how the reliability of the PV system and plant equipment can be expressed in an availability guarantee. This work will improve the bankability of PV systems by providing greater transparency into the equipment reliability state to all parties involved in an O&M services contract.

  15. Development of an energy conservation voluntary agreement pilot project in the steel sector in Shandong

    SciTech Connect

    Price, Lynn; Yun, Jiang; Worrell, Ernst; Wenwei, Du; Sinton, Jonathan E.

    2004-02-05

    facilities of China. Internationally, such a transformation of the industrial sector has been realized in a number of countries using an innovative policy mechanism called Voluntary Agreements. Voluntary Agreements are essentially a contract between the government and industry, or negotiated targets with commitments and time schedules on the part of all participating parties. These agreements typically have a long-term outlook, covering a period of five to ten years, so that strategic energy-efficiency investments can be planned and implemented. A key element of Voluntary Agreements is that they focus the attention of all actors on energy efficiency or emission reduction goals. Internationally, Voluntary Agreements have been shown to result in increased energy efficiency, with the more successful programs even doubling autonomous energy efficiency improvement rates. In addition, Voluntary Agreements have important longer-term impacts including changes of attitudes and awareness of manage rial and technical staff regarding energy efficiency, addressing barriers to technology adoption and innovation, creating market transformation to establish greater potential for sustainable energy-efficiency investments, promoting positive dynamic interactions between different actors involved in technology research and development, deployment, and market development, and facilitating cooperative arrangements that provide learning mechanisms within an industry. The essential steps for reaching a Voluntary Agreement are the assessment of the energy-efficiency potential of the participants as well as target-setting through a negotiated process. Participation by industries is motivated through the use of carrots and sticks, which refers to incentives and disincentives. Supporting programs and policies (the carrots), such as enterprise audits, assessments, benchmarking, monitoring, information dissemination, and financial incentives all play an important role in assisting the participants in

  16. 76 FR 25362 - Cooperative Research and Development Agreement: Butanol Fuel Blend Usage With Marine Outboard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316... SECURITY Coast Guard Cooperative Research and Development Agreement: Butanol Fuel Blend Usage With Marine... Agreement (CRADA) to identify and investigate the use of butanol fuel blends within marine outboard...

  17. 76 FR 44956 - Solicitation for a Cooperative Agreement; Correctional Health Care Executive Curriculum Development

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... National Institute of Corrections Solicitation for a Cooperative Agreement; Correctional Health Care... care, restorative therapy, health information management, and medical specialty services, including... personnel, correctional health care executives must judiciously contract with community-based facilities...

  18. 78 FR 50424 - NIH Cooperative Research and Development Agreement Program: Invitation To Solicit Nonclinical and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... HUMAN SERVICES National Institutes of Health NIH Cooperative Research and Development Agreement Program: Invitation To Solicit Nonclinical and Clinical Research Proposals From NIH Intramural Research Program... organizations); public and private foundations and nonprofit organizations to solicit research proposals...

  19. 78 FR 42084 - Cooperative Agreement to Support the World Trade Organization's Standards and Trade Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Food and Drug Administration Cooperative Agreement to Support the World Trade...) to the World Trade Organization's (WTO) Standards and Trade Development Facility (STDF). DATES... partnership established by the Food and Agriculture Organization, World Organization for Animal Health,...

  20. Development of an Aeroelastic Analysis Including a Viscous Flow Model

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Bakhle, Milind A.

    2001-01-01

    Under this grant, Version 4 of the three-dimensional Navier-Stokes aeroelastic code (TURBO-AE) has been developed and verified. The TURBO-AE Version 4 aeroelastic code allows flutter calculations for a fan, compressor, or turbine blade row. This code models a vibrating three-dimensional bladed disk configuration and the associated unsteady flow (including shocks, and viscous effects) to calculate the aeroelastic instability using a work-per-cycle approach. Phase-lagged (time-shift) periodic boundary conditions are used to model the phase lag between adjacent vibrating blades. The direct-store approach is used for this purpose to reduce the computational domain to a single interblade passage. A disk storage option, implemented using direct access files, is available to reduce the large memory requirements of the direct-store approach. Other researchers have implemented 3D inlet/exit boundary conditions based on eigen-analysis. Appendix A: Aeroelastic calculations based on three-dimensional euler analysis. Appendix B: Unsteady aerodynamic modeling of blade vibration using the turbo-V3.1 code.

  1. Assessment of MSFCs Process for the Development and Activation of Space Act Agreements

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel A.

    2014-01-01

    A Space Act Agreement (SAA) is a contractual vehicle that NASA utilizes to form partnerships with non-NASA entities to stimulate cutting-edge innovation within the science and technology communities while concurrently supporting the NASA missions. SAAs are similar to traditional contracts in that they involve the commitment of Agency resources but allow more flexibility and are more cost effective to implement than traditional contracts. Consequently, the use of SAAs to develop partnerships has greatly increased over the past several years. To facilitate this influx of SAAs, Marshall Space Flight Center (MSFC) developed a process during a kaizen event to streamline and improve the quality of SAAs developed at the Center level. This study assessed the current SAA process to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables. Using a combination of direct procedural observation, personnel interviews, and statistical analysis, elements of the process in need of remediation were identified and potential solutions developed. The findings focus primarily on the difficulties surrounding tracking and enforcing process adherence and communication issues among stakeholders. Potential solutions include utilizing customer relationship management (CRM) software to facilitate process coordination and co-locating or potentially merging the two separate organizations involved in SAA development and activation at MSFC.

  2. Assessment of MSFCs Process for the Development and Activation of Space Act Agreement

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel

    2014-01-01

    Space Act Agreements (SAAs) are contractual agreements that NASA utilizes to form partnerships with researchers, industry, and academia to stimulate cutting-edge innovation within the science and technology communities. center dot This study assessed the current SAA development and activation process at Marshall Space Flight Center (MSFC) to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables.

  3. Learning Agreements and Socially Responsible Approaches to Professional and Human Resource Development in the United Kingdom

    ERIC Educational Resources Information Center

    Wallis, Emma

    2008-01-01

    This article draws upon original qualitative data to present an initial assessment of the significance of learning agreements for the development of socially responsible approaches to professional and human resource development within the workplace. The article suggests that the adoption of a partnership-based approach to learning is more…

  4. 77 FR 19678 - Cooperative Research and Development Agreement: Asset Tracking and Reporting Technology

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... Register (73 FR 3316). Cooperative Research and Development Agreements Cooperative Research and Development... (CRADA) with General Dynamics C4 Systems, Inc. (General Dynamics), to test, evaluate, and document the... participants would test, evaluate, and document the strengths and weaknesses of at least one technical...

  5. 77 FR 1708 - Cooperative Research and Development Agreement: Technology To Provide Wireless Precise Time...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Register (73 FR 3316). Cooperative Research and Development Agreements Cooperative Research and Development... conducting live, on-air tests that will be broadcast from former Long Range Navigation (LORAN) sites, using... these test broadcasts are planned at both on-shore and off-shore locations. The testing will...

  6. Collection Development: Real Steps to Include a Forgotten Group

    ERIC Educational Resources Information Center

    Bell, Dorothy; Gaston, Betty Jo

    2004-01-01

    In the 1950s, the State of Florida led the way in developing a national model for the development of the junior or community college system. The "Brown vs Board of Education" Supreme Court Decision impacted the segregated system and during the 1960s, Florida's 12 black junior colleges were merged with pre-existent majority campuses. This pattern…

  7. Development of a National Agreement on Human Papillomavirus Vaccination in Japan: An Infodemiology Study

    PubMed Central

    Yuji, Koichiro; Tsubokura, Masaharu; Ohsawa, Yukio; Kami, Masahiro

    2014-01-01

    Background A national agreement on human papillomavirus (HPV) vaccination was achieved relatively quickly in Japan as compared to the United States and India. Objective The objective was to identify the role of print and online media references, including references to celebrities or other informants, as factors potentially responsible for the relatively rapid national acceptance of HPV vaccination in Japan. Methods A method of text mining was performed to select keywords, representing the context of the target documents, from articles relevant to the promotion of HPV vaccination appearing in major Japanese newspapers and Web pages between January 2009 and July 2010. The selected keywords were classified as positive, negative, or neutral, and the transition of the frequency of their appearance was analyzed. Results The number of positive and neutral keywords appearing in newspaper articles increased sharply in early 2010 while the number of negative keywords remained low. The numbers of positive, neutral, and negative keywords appearing in Web pages increased gradually and did not significantly differ by category. Neutral keywords, such as “vaccine” and “prevention,” appeared more frequently in newspaper articles, whereas negative keywords, such as “infertility” and “side effect,” appeared more frequently in Web pages. The extraction of the positive keyword “signature campaign” suggests that vaccine beneficiaries cooperated with providers in promoting HPV vaccination. Conclusions The rapid development of a national agreement regarding HPV vaccination in Japan may be primarily attributed to the advocacy of vaccine beneficiaries, supported by advocacy by celebrities and positive reporting by print and online media. PMID:24834471

  8. [Novel insomnia drugs, including drugs currently under development].

    PubMed

    Inada, Ken

    2009-08-01

    Insomnia has mainly been treated with the hypnotic benzodiazepine (BZ). Recent studies have revealed the role and mechanisms of BZ receptors and have led to the development of non-BZ hypnotics. The chemical structures of non-BZ hypnotics differ from that of BZ; these hypnotics selectively bind to the omega 1 receptor of the gamma-aminobutyric acid (GABA)-BZ receptor complex. Because the omega 2 BZ receptors have adverse effects such as muscle relaxant actions, non-BZ hypnotics have lesser adverse effects than BZ. Antipsychotics, antidepressants, and antihistamines are also used for the treatment of insomnia in patients with other medical problems such as schizophrenia and depression. Currently, novel hypnotics are being developed with the manipulation of neurotransmitters and non-GABAergic receptors such as the melatonin and serotonin receptors. PMID:19768946

  9. Space Act Agreement Maker (SAAM) With Electronic Routing System (ERouter) Developed

    NASA Technical Reports Server (NTRS)

    Stauber, Laurel J.

    2003-01-01

    Members of the Commercial Technology Office at the NASA Glenn Research Center have developed an exciting new tool that greatly reduces the lead time in creating and routing Space Act Agreements. The Space Act Agreement Maker (SAAM) is an e-government Web-based system that automates the initial drafting of Space Act Agreements by technical and program personnel. SAAM also is used for editing and will be used later for maintaining electronic copies of all Space Act Agreements. During the initial drafting, the software prompts NASA personnel proposing an agreement to answer questions regarding the agreement. On the basis of the answers, the software selects from a matrix of NASA standard clauses to produce a first draft of the agreement. The draft agreement and information submitted by the NASA personnel are electronically routed to Glenn s Commercial Technology Office for review and, where necessary, editing. The final version of the agreement, along with any supporting documentation, is then routed for electronic concurrence/approval to the necessary internal review participants using the electronic routing system (e-router). SAAM was developed cooperatively by Glenn s Commercial Technology Office and Glenn s Office of Chief Counsel. Currently, SAAM is being evaluated by the NASA Headquarters General Counsel Office for use at all NASA centers. This system allows for the effective processing of Space Act Agreements for NASA s internal and external customers. Document control is maintained by a database. With SAAM s electronic routing, review times can be reduced significantly, allowing Glenn to more rapidly establish partnerships with industry. Prior to the creation of SAAM, it took several hours to draft a Space Act Agreement. With SAAM in place, the document can be written in about 30 min. Using the e-router also saves time in determining where the agreement is in the routing process. The document can be tracked easily, and delays can be avoided. Important research

  10. 77 FR 39741 - Solicitation for a Cooperative Agreement-Curricula Review and Revision: NIC Trainer Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ...The National Institute of Corrections' (NIC) Academy Division is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement for the review, revision, and/or development of competency-based, blended modality training curricula with the aim of providing corrections agencies and professionals with the knowledge, skills, and abilities needed to train and......

  11. 34 CFR 363.50 - What collaborative agreements must the State develop?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What collaborative agreements must the State develop? 363.50 Section 363.50 Education Regulations of the Offices of the Department of Education (Continued... EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State? § 363.50 What...

  12. 34 CFR 363.50 - What collaborative agreements must the State develop?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true What collaborative agreements must the State develop? 363.50 Section 363.50 Education Regulations of the Offices of the Department of Education (Continued... EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State? § 363.50 What...

  13. 34 CFR 363.50 - What collaborative agreements must the State develop?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true What collaborative agreements must the State develop? 363.50 Section 363.50 Education Regulations of the Offices of the Department of Education (Continued... EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State? § 363.50 What...

  14. 34 CFR 363.50 - What collaborative agreements must the State develop?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false What collaborative agreements must the State develop? 363.50 Section 363.50 Education Regulations of the Offices of the Department of Education (Continued... EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State? § 363.50 What...

  15. 34 CFR 363.50 - What collaborative agreements must the State develop?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false What collaborative agreements must the State develop? 363.50 Section 363.50 Education Regulations of the Offices of the Department of Education (Continued... EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State? § 363.50 What...

  16. 77 FR 31008 - Enforceable Consent Agreement Development for Two Cyclic Siloxanes; Solicitation of Interested...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    .... Final Rule. 54 FR 818, January 10, 1989. 3. SEHSC. Memorandum from Karluss Thomas. Executive Director... the Dow Corning Corporation; Notice of Receipt and Availability of the MOU Data. 74 FR 38013, July 30... AGENCY Enforceable Consent Agreement Development for Two Cyclic Siloxanes; Solicitation of...

  17. 75 FR 56112 - Integrated Food Safety System Online Collaboration Development-Cooperative Agreement With the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... HUMAN SERVICES Food and Drug Administration Integrated Food Safety System Online Collaboration Development-- Cooperative Agreement With the National Center for Food Protection and Defense (U18) AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  18. The Development of a Revised Written Agreement Between Affiliated Clinical Sites and Spartanburg Technical College.

    ERIC Educational Resources Information Center

    Atkins, Karen B.

    In 1968, an affiliation agreement was developed between Spartanburg Technical College (STC) and the first clinical site that provided the medical and health laboratory facilities necessary for the on-site training of STC's allied health science students. By 1978, a number of administrative and policy changes that had taken place at Spartanburg and…

  19. 48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Sponsoring Agreement (DEC 2000) (a) Pursuant to 48 CFR 35.017-1, this contract constitutes the sponsoring... the operation of a Department of Energy sponsored Federally Funded Research and Development Center... provided by the contract, the Contractor may accept work from a nonsponsor (as defined in 48 CFR 35.017)...

  20. 77 FR 25488 - Cooperative Research and Development Agreement: Federally Integrated Communications System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ...The Coast Guard is announcing its intent to enter into a Cooperative Research and Development Agreement (CRADA) with General Dynamics C4 Systems, Inc. to lab demonstrate, field test, evaluate, and document at least one technical approach to show interoperability, with end-to-end encryption, for disparate Federal communications systems at the Internet Protocol level. The Coast Guard invites......

  1. 77 FR 48165 - Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of Homeland Security for the Efficacy Testing of Vaporous Hydrogen Peroxide (VHP) and Chlorine Dioxide (ClO 2 )...

  2. 77 FR 4363 - Solicitation for a Cooperative Agreement-Curriculum Development: Thinking for a Change 3.1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--Curriculum Development.... Department of Justice. ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of... curriculum for T4C 3.1 Training for Facilitators. Scope of Work: At the end of this cooperative agreement,...

  3. A national laboratory/private industry cooperative research and development agreement (CRADA)

    SciTech Connect

    Pritchard, D.A.; MacEachin, J.

    1996-09-01

    This paper provides an overview of the history and process of establishing a cooperative research and development agreement (CRADA) between Sandia National Laboratories and Magnavox Electronic Systems Company for the design, development, and testing of a 360-degree scanning, imaging, intrusion detection sensor. The subject of the CRADA is the Advanced Exterior Sensor (AES). It is intended for exterior use at ranges from 50 to 1,500 meters and uses a combination of three sensing technologies (infrared, visible, and radar) and a new data processing method to provide low false-alarm intrusion detection and tracking combined with immediate visual assessment. The establishment of this CRADA represents a new paradigm in the cooperation between the Department of Defense, the Department of Energy, the National Laboratories and Private Industry. Although a formal document has now been executed, a CRADA is, nonetheless, primarily an agreement to work with each other to achieve goals that might otherwise be unattainable.

  4. Nondestructive testing of ceramic components: Cooperative research and development agreement completion report

    SciTech Connect

    Carpenter, D.A.; Dews, T.W.; Moyer, M.W.; Oakes, R.E.

    1994-12-22

    In a joint Cooperative Research and Development Agreement (CRADA) between Martin Marietta Energy Systems (MMES) and an industrial partner, Y-12 has been evaluating nondestructive evaluation (NDE) techniques to identify the quality of high strength aluminum oxide tubes used in laser applications. In Phase I, several NDE techniques were developed to inspect the tubes. In Phase II a correlation between detected defects, actual failure mode and strength of the tubes was developed. In Phase II the industrial partner supplied tubes manufactured under a variety of conditions and containing material defects expected from process control variations. The tubes were inspected at MMES utilizing a variety of available acoustic techniques. After inspection, ring tensile specimens were fabricated to determine the tensile strength. The data were evaluated utilizing Weibull statistics to determine the statistical impact of the defects upon strength and correlate the data with the nondestructive evaluations of the tubes and observed defect distribution.

  5. Technology Cooperation Agreement Pilot Project development-friendly greenhouse gas reduction, May 1999 update

    SciTech Connect

    Benioff, R.

    1999-05-11

    The Technology Cooperation Agreement Pilot Project (TCAPP) was launched by several U.S. Government agencies (USAID, EPA and DOE) in August 1997 to establish a model for climate change technology cooperation with developing and transition countries. TCAPP is currently facilitating voluntary partnerships between the governments of Brazil, China, Kazakhstan, Korea, Mexico, and the Philippines, the private sector, and the donor community on a common set of actions that will advance implementation of clean energy technologies. The six participating countries have been actively engaged in shaping this initiative along with international donors and the private sector. This program helps fulfill the US obligation to support technology transfer to developing countries under Article 4.5 of the United Nations Framework Convention on Climate Change. TCAPP also provides a mechanism to focus resources across international donor programs on the technology cooperation needs of developing and transition countries.

  6. 78 FR 43923 - Solicitation for a Cooperative Agreement-Executive Excellence a Training and Development Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--Executive Excellence a Training.... Department of Justice. ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of... cooperative agreement for a 15-month period to begin no later than September 15, 2013. This project will be...

  7. 78 FR 43925 - Solicitation for a Cooperative Agreement-Executive Excellence a Training and Development Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--Executive Excellence a Training.... Department of Justice. ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of... cooperative agreement for a 15-month period to begin no later than September 15, 2013. This project will be...

  8. 40 CFR Appendix A to Subpart E of... - Schedule for Developing Consent Agreements and Test Rules

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Agreements and Test Rules A Appendix A to Subpart E of Part 790 Protection of Environment ENVIRONMENTAL... AGREEMENTS AND TEST RULES Exemptions From Test Rules Pt. 790, Subpt. E, App. A Appendix A to Subpart E of... required under section 4(a) of TSCA but agreement cannot be reached in timely manner on a consent...

  9. 75 FR 61503 - Cooperative Agreement With the World Health Organization for a Plan to Develop a Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES Food and Drug Administration Cooperative Agreement With the World Health Organization for a Plan to Develop a Global Integrated Food Safety Information Platform AGENCY: Food and Drug... accept and consider a single source application for awarding a cooperative agreement to the World...

  10. 28 CFR 56.2 - Maintenance of records with respect to meetings held to develop voluntary agreements or plans of...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Maintenance of records with respect to meetings held to develop voluntary agreements or plans of action pursuant to the Agreement on an International Energy Program. 56.2 Section 56.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) INTERNATIONAL ENERGY PROGRAM § 56.2...

  11. 28 CFR 56.2 - Maintenance of records with respect to meetings held to develop voluntary agreements or plans of...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Maintenance of records with respect to meetings held to develop voluntary agreements or plans of action pursuant to the Agreement on an International Energy Program. 56.2 Section 56.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) INTERNATIONAL ENERGY PROGRAM § 56.2...

  12. Developing sorbent standards for spill response: Effects of the Oil Pollution Act of 1990 and the Free Trade Agreement

    NASA Astrophysics Data System (ADS)

    Schrader, E. L.; Westover, E. S.

    1993-09-01

    For the past five years the Millsaps Sorbent Laboratory has been actively engaged in developing standards for initial and long-term oil spill remedial technologies. As a voting member of the American Society of Testing Materials (ASTM) F-20 Committee, Canadian General Standards Board, and the US Coast Guard Sorbents Task Force, the laboratory has been engaged in developing useful, pragmatic protocols for various chemical and physical sorbent and filtration technologies driven by the deadlines imposed by the Oil Pollution Act of 1990 (OPA 90). The “open border” approach to certification of technologies and products promulgated by the US/Canadian Free Trade Agreement has placed the US users and producers of such products and systems in a unique and tenuous position. Canadian standards and goals are grandfathered into the United States under this agreement and products have official US government certification based on Canadian regulations. This situation is unfavorable to the US domestic environment and economy for several specific scenarios. Included in these scenarios are: abundant warmwater zones and inland waters of the US versus Canada, the basic chemical variation between Canadian and US crude oils, the different generally accepted remediation technologies in the US versus Canadian, and the technology validation procedures prior to purchase inherent to both countries.

  13. 75 FR 61502 - Cooperative Agreement With the Pan American Health Organization for the Development of an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES Food and Drug Administration Cooperative Agreement With the Pan American Health... application to award a cooperative agreement to the Pan American Health Organization (PAHO) for the... efforts, such as the Pan American Network for Drug Regulatory Harmonization (PANDRH), the ICH...

  14. Agreement and Null Subjects in German L2 Development: New Evidence from Reaction-Time Experiments.

    ERIC Educational Resources Information Center

    Clahsen, Harald; Hong, Upyong

    1995-01-01

    Reports on reaction time experiments investigating subject-verb agreement and null subjects in 33 Korean learners of German and a control group of 20 German native speakers. Results found that the two phenomena do not covary in the Korean learners, indicating that properties of agreement and null subjects are acquired separately from one another.…

  15. European Union’s Public Fishing Access Agreements in Developing Countries

    PubMed Central

    Le Manach, Frédéric; Chaboud, Christian; Copeland, Duncan; Cury, Philippe; Gascuel, Didier; Kleisner, Kristin M.; Standing, André; Sumaila, U. Rashid; Zeller, Dirk; Pauly, Daniel

    2013-01-01

    The imperative to increase seafood supply while dealing with its overfished local stocks has pushed the European Union (EU) and its Member States to fish in the Exclusive Economic Zones of other countries through various types of fishing agreements for decades. Although European public fishing agreements are commented on regularly and considered to be transparent, this is the first global and historical study on the fee regime that governs them. We find that the EU has subsidized these agreements at an average of 75% of their cost (financial contribution agreed upon in the agreements), while private European business interests paid the equivalent of 1.5% of the value of the fish that was eventually landed. This raises questions of fisheries benefit-sharing and resource-use equity that the EU has the potential to address during the nearly completed reform of its Common Fisheries Policy. PMID:24312191

  16. 22 CFR Appendix A to Part 201 - Supplier's Certificate and Agreement With the Agency for International Development (AID 282)

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Agency for International Development (AID 282) A Appendix A to Part 201 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES APPLICABLE TO COMMODITY TRANSACTIONS FINANCED BY USAID Pt. 201, App. A Appendix A to Part 201—Supplier's Certificate and Agreement With the Agency for...

  17. 22 CFR Appendix A to Part 201 - Supplier's Certificate and Agreement With the Agency for International Development (AID 282)

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Agency for International Development (AID 282) A Appendix A to Part 201 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES APPLICABLE TO COMMODITY TRANSACTIONS FINANCED BY USAID Pt. 201, App. A Appendix A to Part 201—Supplier's Certificate and Agreement With the Agency for...

  18. Development of indirect EFBEM for radiating noise analysis including underwater problems

    NASA Astrophysics Data System (ADS)

    Kwon, Hyun-Wung; Hong, Suk-Yoon; Song, Jee-Hun

    2013-09-01

    For the analysis of radiating noise problems in medium-to-high frequency ranges, the Energy Flow Boundary Element Method (EFBEM) was developed. EFBEM is the analysis technique that applies the Boundary Element Method (BEM) to Energy Flow Analysis (EFA). The fundamental solutions representing spherical wave property for radiating noise problems in open field and considering the free surface effect in underwater are developed. Also the directivity factor is developed to express wave's directivity patterns in medium-to-high frequency ranges. Indirect EFBEM by using fundamental solutions and fictitious source was applied to open field and underwater noise problems successfully. Through numerical applications, the acoustic energy density distributions due to vibration of a simple plate model and a sphere model were compared with those of commercial code, and the comparison showed good agreement in the level and pattern of the energy density distributions.

  19. 34 CFR 606.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... development grant applications? In addition to the information needed by the Secretary to determine whether... application for a development grant must include— (a) The institution's comprehensive development plan; (b) A... 34 Education 3 2012-07-01 2012-07-01 false What must be included in individual development...

  20. 34 CFR 606.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... development grant applications? In addition to the information needed by the Secretary to determine whether... application for a development grant must include— (a) The institution's comprehensive development plan; (b) A... 34 Education 3 2014-07-01 2014-07-01 false What must be included in individual development...

  1. 34 CFR 606.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... development grant applications? In addition to the information needed by the Secretary to determine whether... application for a development grant must include— (a) The institution's comprehensive development plan; (b) A... 34 Education 3 2013-07-01 2013-07-01 false What must be included in individual development...

  2. 34 CFR 606.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... development grant applications? In addition to the information needed by the Secretary to determine whether... application for a development grant must include— (a) The institution's comprehensive development plan; (b) A... 34 Education 3 2011-07-01 2011-07-01 false What must be included in individual development...

  3. 48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Sponsoring Agreement (DEC 2010) (a) Pursuant to 48 CFR 35.017-1, this contract constitutes the sponsoring... provided by the contract, the Contractor may accept work from a nonsponsor (as defined in 48 CFR 35.017) in accordance with the requirements and limitations of the clause 48 CFR 970.5217-1 Work for Others Program....

  4. 48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Sponsoring Agreement (DEC 2010) (a) Pursuant to 48 CFR 35.017-1, this contract constitutes the sponsoring... provided by the contract, the Contractor may accept work from a nonsponsor (as defined in 48 CFR 35.017) in accordance with the requirements and limitations of the clause 48 CFR 970.5217-1 Work for Others Program....

  5. 48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Sponsoring Agreement (DEC 2010) (a) Pursuant to 48 CFR 35.017-1, this contract constitutes the sponsoring... provided by the contract, the Contractor may accept work from a nonsponsor (as defined in 48 CFR 35.017) in accordance with the requirements and limitations of the clause 48 CFR 970.5217-1 Work for Others Program....

  6. 48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Sponsoring Agreement (DEC 2010) (a) Pursuant to 48 CFR 35.017-1, this contract constitutes the sponsoring... provided by the contract, the Contractor may accept work from a nonsponsor (as defined in 48 CFR 35.017) in accordance with the requirements and limitations of the clause 48 CFR 970.5217-1 Work for Others Program....

  7. 34 CFR 607.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What must be included in individual development grant applications? 607.11 Section 607.11 Education Regulations of the Offices of the Department of Education... Does an Institution Apply for a Grant? § 607.11 What must be included in individual development...

  8. 34 CFR 607.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What must be included in individual development grant applications? 607.11 Section 607.11 Education Regulations of the Offices of the Department of Education... Does an Institution Apply for a Grant? § 607.11 What must be included in individual development...

  9. 34 CFR 607.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What must be included in individual development grant applications? 607.11 Section 607.11 Education Regulations of the Offices of the Department of Education... Does an Institution Apply for a Grant? § 607.11 What must be included in individual development...

  10. 34 CFR 607.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What must be included in individual development grant applications? 607.11 Section 607.11 Education Regulations of the Offices of the Department of Education... Does an Institution Apply for a Grant? § 607.11 What must be included in individual development...

  11. 42 CFR 403.910 - Delayed publication for payments made under product research or development agreements and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Delayed publication for payments made under product research or development agreements and clinical investigations. 403.910 Section 403.910 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS...

  12. Cooperative Research and Development Agreement between the California Air Resources Board and Lockheed Martin Idaho Technologies Company. Final report

    SciTech Connect

    Cole, G.H.

    1998-04-01

    This report summarizes the activities under a Cooperative Research and Development Agreement (CRADA) between Lockheed-Martin Idaho Technologies Company (LMITCO) and the California Air Resources Board (CARB). The activities were performed at the Idaho National Engineering and Environmental Laboratory (INEEL) between June 1995 and December 1997. Work under this agreement was concentrated in two task areas as defined in the California Air Resources Board`s contract number 94-908 having an approval date of June 9, 1995: Task 1--EV and HEV Vehicle Testing and Assessment and Task 4--Advanced Battery Testing.

  13. Participating in commercial space ventures: Introduction to NASA Centers for the Commercial Development of Space and the Cooperative Agreements Programs

    NASA Technical Reports Server (NTRS)

    1990-01-01

    In response to a Presidential directive, NASA has implemented a space policy which actively supports and encourages U.S. industry investment and participation in commercial space ventures. NASA's Office of Commercial Programs (OCP) has played a significant role in stimulating the growth of commercial space activity. Through a variety of programs, OCP encourages commercial interest and involvement in space endeavors by providing access to NASA resources and opportunities for the emerging space industry to reduce the technical, financial, and business risks associated with space-related activities. This manual describes NASA's Commercial Uses of Space Program and introduces participants to four major OCP Commercial programs: Technology Utilization (TU), Small Business Innovation Research (SBIR), Centers for the Commercial Development of Space Flight Agreement (CCDSFA), and Cooperative Agreements Programs. The objective of this manual is to assist U.S. industry identify and pursue the appropriate agreement for participation in a commercial space venture.

  14. 34 CFR 263.4 - What training costs may a Professional Development program include?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false What training costs may a Professional Development program include? 263.4 Section 263.4 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION INDIAN EDUCATION DISCRETIONARY GRANT PROGRAMS Professional Development...

  15. 34 CFR 606.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must be included in individual development grant applications? 606.11 Section 606.11 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  16. Development of a cost-effectiveness analysis of leafy green marketing agreement irrigation water provisions.

    PubMed

    Jensen, Helen H; Pouliot, Sébastien; Wang, Tong; Jay-Russell, Michele T

    2014-06-01

    An analysis of the effectiveness of meeting the irrigation water provisions of the Leafy Green Marketing Agreement (LGMA) relative to its costs provides an approach to evaluating the cost-effectiveness of good agricultural practices that uses available data. A case example for lettuce is used to evaluate data requirements and provide a methodological example to determine the cost-effectiveness of the LGMA water quality provision. Both cost and field data on pathogen or indicator bacterial levels are difficult and expensive to obtain prospectively. Therefore, methods to use existing field and experimental data are required. Based on data from current literature and experimental studies, we calculate a cost-efficiency ratio that expresses the reduction in E. coli concentration per dollar expenditure on testing of irrigation water. With appropriate data, the same type of analysis can be extended to soil amendments and other practices and to evaluation of public benefits of practices used in production. Careful use of existing and experimental data can lead to evaluation of an expanded set of practices. PMID:24853531

  17. 23 CFR 630.108 - Preparation of agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PRECONSTRUCTION PROCEDURES Project Authorization and Agreements § 630.108 Preparation of agreement. (a) The STD shall prepare a project agreement for each Federal-aid project. (b) The STD may develop the project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1)...

  18. 23 CFR 630.108 - Preparation of agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PRECONSTRUCTION PROCEDURES Project Authorization and Agreements § 630.108 Preparation of agreement. (a) The STD shall prepare a project agreement for each Federal-aid project. (b) The STD may develop the project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1)...

  19. 23 CFR 630.108 - Preparation of agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PRECONSTRUCTION PROCEDURES Project Authorization and Agreements § 630.108 Preparation of agreement. (a) The STD shall prepare a project agreement for each Federal-aid project. (b) The STD may develop the project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1)...

  20. 78 FR 35321 - Solicitation for a Cooperative Agreement-IBM Instructional Guide and Assessment Tool Development

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE... Assessment Tool Development AGENCY: National Institute of Corrections, U.S. Department of Justice. ACTION... development of an instructional guide and assessment tool(s) that will help jail practitioners improve...

  1. 75 FR 1814 - Solicitation for a Cooperative Agreement-Curriculum Development: Training for Correctional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ...The National Institute of Corrections' (NIC) Transition and Offender Workforce Development (T/OWD) and Academy Divisions are seeking applications for the development of a competency based, blended modality training curriculum that will provide Correctional Industries Directors with the knowledge, skills and abilities needed to set organizational priorities, identify strategic objectives,......

  2. 34 CFR 263.4 - What training costs may a Professional Development program include?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What training costs may a Professional Development program include? 263.4 Section 263.4 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION INDIAN EDUCATION...

  3. 34 CFR 607.11 - What must be included in individual development grant applications?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must be included in individual development grant applications? 607.11 Section 607.11 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM...

  4. Brandon Research, Inc. Orthopedic Implant Cooperative Research and Development Agreement (CRADA) Final Report

    SciTech Connect

    Freeman, W.R.

    1999-04-22

    The project was a joint research effort between the U. S. Department of Energy's (DOE) Kansas City Plant (KCP) and Brandon Research, Inc. to develop ways to improve implants used for orthopedic surgery for joint replacement. The primary product produced by this study is design information, which may be used to develop implants that will improve long-term fixation and durability in the host bone environment.

  5. 22 CFR 1509.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cooperative agreement. 1509.620 Section 1509.620 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE... award. The term does not include cooperative research and development agreements as defined in 15...

  6. Laser-communication cooperative research and development agreement between Air Force Phillips Lab and Ball Aerospace

    NASA Astrophysics Data System (ADS)

    Begley, David L.; Kehr, Robert L.; Sarto, Anthony W.; Casey, William; Coffelt, Everett L.; Goodrich, Alan; Thompson, William E.

    1997-04-01

    This paper presents an overview of a cooperative research and development program between Ball Aerospace and Technologies Corp. and the Air Force Phillips Laboratory for laser communications. This effort employs hardware and equipment originally developed to support the crosslinking between geostationary Defense Support Program surveillance satellites. This joint activity modifies the existing hardware for ground based demonstrations and simulations focuses at risk reduction for future applications and technology insertion into operational architectures meeting future commercial, civil, and DOD communications requirements. The ultimate goal of the program is to produce hardware for a near term flight demonstration. A brief overview of the capabilities of the existing hardware will be presented followed by a status of the development efforts and future plans.

  7. Constituencies, Clients, and Agreement in Rural Development: A Preliminary Statement for Project S-120.

    ERIC Educational Resources Information Center

    Voth, Donald E.

    Objective B of the Regional Project Statement for Project S-120 is "to determine perceptions toward development in activities, agency representatives, and clientele affected by organizational and agency activities". This paper addresses Objective B and presents a perspective which "suggests an answer to the inevitable 'so what' question when…

  8. 75 FR 52552 - Solicitation for a Cooperative Agreement-Curriculum Development: Implementing and Sustaining an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    .... The curriculum must adhere to NIC's Instructional Theory into Practice (ITIP) model, which applicants... should be developed using NIC's Instructional Theory into Practice (ITIP) model. The curriculum should... corrections supervisors and managers with the knowledge, skills, and abilities needed to model,...

  9. Agreements at the Pharmaceutical/University Interface.

    ERIC Educational Resources Information Center

    Ku, Katherine

    1987-01-01

    Specific agreements that arise at the interface between universities and pharmaceutical companies are described including sponsored research agreements, license agreements, clinical study agreements, material transfer agreements, and patient consent forms with respect to commercialization rights. (Author/MLW)

  10. 78 FR 28866 - Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ...The Department of Homeland Security Science and Technology Directorate (DHS S&T), through its Plum Island Animal Disease Center (PIADC), is seeking industry collaborators to aid DHS S&T in developing an ELISA diagnostic test that it capable of obtaining a U.S. regulatory license to detect antibodies to at least one of the Foot and Mouth Disease virus (FMDV) non-structural proteins (NSP): 3A,......

  11. Sexual Agreements among Gay Male Couples

    PubMed Central

    Hoff, Colleen H.; Beougher, Sean C.

    2009-01-01

    Many gay male couples make agreements about whether or not to permit sex with outside partners, yet little is known about the development and maintenance of these agreements, their impact on relationships, and whether they are an effective HIV prevention strategy. Using semi-structured, qualitative interviews, 39 gay male couples were asked about their sexual agreements and about other relationship dynamics that might affect their agreements. Analysis revealed a wide range of agreement types, all of which are presented along a continuum rather than as discrete categories. For couples with open agreements, most placed rules or conditions limiting when, where, how often, and with whom outside sex was permitted. Although motivations for having agreements varied, HIV prevention did not rank as a primary factor for any couple. Most couples had congruous agreements; however, a small number reported discrepancies which may increase HIV transmission risk. How couples handled breaks in their agreements also varied, depending on what condition was broken, whether it was disclosed, and the partner's reaction. Additional results include differences in agreement type and motivations for having an agreement based on couple serostatus. Overall, agreements benefited couples by providing boundaries for the relationship, supporting a non-heteronormative identity, and fulfilling the sexual needs of the couple. Future prevention efforts involving gay couples must address the range of agreement types and the meanings couples ascribe to them, in addition to tempering safety messages with the relationship issues that are important to and faced by gay couples. PMID:18686027

  12. Low voltage 30-cm ion thruster development. [including performance and structural integrity (vibration) tests

    NASA Technical Reports Server (NTRS)

    King, H. J.

    1974-01-01

    The basic goal was to advance the development status of the 30-cm electron bombardment ion thruster from a laboratory model to a flight-type engineering model (EM) thruster. This advancement included the more conventional aspects of mechanical design and testing for launch loads, weight reduction, fabrication process development, reliability and quality assurance, and interface definition, as well as a relatively significant improvement in thruster total efficiency. The achievement of this goal was demonstrated by the successful completion of a series of performance and structural integrity (vibration) tests. In the course of the program, essentially every part and feature of the original 30-cm Thruster was critically evaluated. These evaluations, led to new or improved designs for the ion optical system, discharge chamber, cathode isolator vaporizer assembly, main isolator vaporizer assembly, neutralizer assembly, packaging for thermal control, electrical terminations and structure.

  13. Follow-On Cooperative Research and Development Agreement: MFIX to FLUENT Technology Transfer and Validation Studies Final Report

    SciTech Connect

    Madhava Syamlal; Guenther, Chris; O'Brien, Thomas J.; Benyahia, Sofiane; Shi, Shaoping

    2005-03-01

    This report summarizes the effort by NETL and Fluent on the Cooperative Research and Development Agreement No. 00-F039 signed in May 2000. The objective of the CRADA was to transfer technology from NETL's MFIX code into the commercial software FLUENT so as to increase the computational speed, accuracy, and utility of FLUENT. During the period of this CRADA MFIX was used to develop granular flow theories and used for simulating gas-solids chemical reactors. The FLUENT and MFIX predictions were compared with each other and with experimental data generated at NETL. The granular kinetic theory in FLUENT was improved as a result of this work, and a gas-solids reaction (ozone decomposition) was used as a test case for the gas-solids chemical reaction capability in FLUENT. Also, under a separate project, work has begun to transfer the coal combustion and gasification model in MFIX to FLUENT.

  14. 22 CFR 1008.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cooperative agreement. 1008.620 Section 1008.620 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... term does not include cooperative research and development agreements as defined in 15 U.S.C. 3710a....

  15. 45 CFR 630.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... carrying out the activity contemplated by the award. The term does not include cooperative research and development agreements as defined in 15 U.S.C. 3710a....

  16. Supermarket revolution in Asia and emerging development strategies to include small farmers.

    PubMed

    Reardon, Thomas; Timmer, C Peter; Minten, Bart

    2012-07-31

    A "supermarket revolution" has occurred in developing countries in the past 2 decades. We focus on three specific issues that reflect the impact of this revolution, particularly in Asia: continuity in transformation, innovation in transformation, and unique development strategies. First, the record shows that the rapid growth observed in the early 2000s in China, Indonesia, Malaysia, and Thailand has continued, and the "newcomers"--India and Vietnam--have grown even faster. Although foreign direct investment has been important, the roles of domestic conglomerates and even state investment have been significant and unique. Second, Asia's supermarket revolution has exhibited unique pathways of retail diffusion and procurement system change. There has been "precocious" penetration of rural towns by rural supermarkets and rural business hubs, emergence of penetration of fresh produce retail that took much longer to initiate in other regions, and emergence of Asian retail developing-country multinational chains. In procurement, a symbiosis between modern retail and the emerging and consolidating modern food processing and logistics sectors has arisen. Third, several approaches are being tried to link small farmers to supermarkets. Some are unique to Asia, for example assembling into a "hub" or "platform" or "park" the various companies and services that link farmers to modern markets. Other approaches relatively new to Asia are found elsewhere, especially in Latin America, including "bringing modern markets to farmers" by establishing collection centers and multipronged collection cum service provision arrangements, and forming market cooperatives and farmer companies to help small farmers access supermarkets. PMID:21135250

  17. JouleLabs Cooperative Research and Development Agreement: Cooperative Research and Development Final Report, CRADA Number CRD-08-00301

    SciTech Connect

    Bilello, D.

    2010-08-01

    The National Renewable Energy Laboratory (NREL) and Joule Labs Inc. (Joule Labs) will collaborate on creating a software platform for the development and distribution of renewable energy and energy efficiency analysis tools.

  18. 7 CFR Exhibit B to Subpart B of... - Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...—Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or Public... costs of housing or public facilities. This Grant Agreement covers the following described real property... Copeland “Anti-Kick Back” Act (18 USC 874) as supplemented in Department of Labor regulations (29 CFR,...

  19. 7 CFR Exhibit B to Subpart B of... - Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...—Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or Public... costs of housing or public facilities. This Grant Agreement covers the following described real property... Copeland “Anti-Kick Back” Act (18 USC 874) as supplemented in Department of Labor regulations (29 CFR,...

  20. 7 CFR Exhibit B to Subpart B of... - Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or Public... costs of housing or public facilities. This Grant Agreement covers the following described real property... Copeland “Anti-Kick Back” Act (18 USC 874) as supplemented in Department of Labor regulations (29 CFR,...

  1. 7 CFR Exhibit B to Subpart B of... - Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...—Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or Public... costs of housing or public facilities. This Grant Agreement covers the following described real property... Copeland “Anti-Kick Back” Act (18 USC 874) as supplemented in Department of Labor regulations (29 CFR,...

  2. DEVELOPMENT OF A PRODUCT MODEL FOR CUT-AND-COVER TUNNELS INCLUDING DEGRADATIONS

    NASA Astrophysics Data System (ADS)

    Aruga, Takashi; Yabuki, Nobuyoshi; Arai, Yasushi

    Cut-and-Cover tunnels are constructed on site. The various conditions of environments and techniques of construction make a significant influence on the quality of the tunnel. It is extremely difficult to rebuild the tunnel even if a structural trouble is found once the construction is completed. Thus, suitable maintenance is needed to ensure the tunnel is in a healthy condition. To execute better maintenance, the information on design and construction of the tunnel is vital for inspection of degradation, estimation of occurrence factors and planning of repair or refurbishing works. In this paper, we developed a product model for representing cut-and-cover tunnels including degradations for effective information use in maintenance work. As its first step, we investigated the characteristics of cut-and-cover tunnels and degradations about reinforced concrete members and developed a conceptual model. Then, we implemented the conceptual product model by expanding Industry Foundation Classes (IFC). Finally, we verified the product model by applying it to a simple tunnel.

  3. An agreement coefficient for image comparison

    USGS Publications Warehouse

    Ji, L.; Gallo, K.

    2006-01-01

    Combination of datasets acquired from different sensor systems is necessary to construct a long time-series dataset for remotely sensed land-surface variables. Assessment of the agreement of the data derived from various sources is an important issue in understanding the data continuity through the time-series. Some traditional measures, including correlation coefficient, coefficient of determination, mean absolute error, and root mean square error, are not always optimal for evaluating the data agreement. For this reason, we developed a new agreement coefficient for comparing two different images. The agreement coefficient has the following properties: non-dimensional, bounded, symmetric, and distinguishable between systematic and unsystematic differences. The paper provides examples of agreement analyses for hypothetical data and actual remotely sensed data. The results demonstrate that the agreement coefficient does include the above properties, and therefore is a useful tool for image comparison. ?? 2006 American Society for Photogrammetry and Remote Sensing.

  4. Supermarket revolution in Asia and emerging development strategies to include small farmers

    PubMed Central

    Reardon, Thomas; Timmer, C. Peter; Minten, Bart

    2012-01-01

    A “supermarket revolution” has occurred in developing countries in the past 2 decades. We focus on three specific issues that reflect the impact of this revolution, particularly in Asia: continuity in transformation, innovation in transformation, and unique development strategies. First, the record shows that the rapid growth observed in the early 2000s in China, Indonesia, Malaysia, and Thailand has continued, and the “newcomers”—India and Vietnam—have grown even faster. Although foreign direct investment has been important, the roles of domestic conglomerates and even state investment have been significant and unique. Second, Asia's supermarket revolution has exhibited unique pathways of retail diffusion and procurement system change. There has been “precocious” penetration of rural towns by rural supermarkets and rural business hubs, emergence of penetration of fresh produce retail that took much longer to initiate in other regions, and emergence of Asian retail developing-country multinational chains. In procurement, a symbiosis between modern retail and the emerging and consolidating modern food processing and logistics sectors has arisen. Third, several approaches are being tried to link small farmers to supermarkets. Some are unique to Asia, for example assembling into a “hub” or “platform” or “park” the various companies and services that link farmers to modern markets. Other approaches relatively new to Asia are found elsewhere, especially in Latin America, including “bringing modern markets to farmers” by establishing collection centers and multipronged collection cum service provision arrangements, and forming market cooperatives and farmer companies to help small farmers access supermarkets. PMID:21135250

  5. Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.

    PubMed

    Srinivas, Nuggehally R

    2006-05-01

    The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development culminating in a marketing approval. Although the bioanalytical procedure(s) originally developed during the discovery stage may not necessarily be fit to support the drug development scenario, they may be suitably modified and validated, as deemed necessary. Several reviews have appeared over the years describing analytical approaches including various techniques, detection systems, automation tools that are available for an effective separation, enhanced selectivity and sensitivity for quantitation of many analytes. The intention of this review is to cover various key areas where analytical method development becomes necessary during different stages of drug discovery research and development process. The key areas covered in this article with relevant case studies include: (a) simultaneous assay for parent compound and metabolites that are purported to display pharmacological activity; (b) bioanalytical procedures for determination of multiple drugs in combating a disease; (c) analytical measurement of chirality aspects in the pharmacokinetics, metabolism and biotransformation investigations; (d) drug monitoring for therapeutic benefits and/or occupational hazard; (e) analysis of drugs from complex and/or less frequently used matrices; (f) analytical determination during in vitro experiments (metabolism and permeability related) and in situ intestinal perfusion experiments; (g) determination of a major metabolite as a surrogate for the parent molecule; (h) analytical approaches for universal determination of CYP450 probe substrates and metabolites; (i) analytical applicability to prodrug evaluations-simultaneous determination of prodrug, parent and metabolites; (j) quantitative determination of parent compound and/or phase II metabolite(s) via direct or indirect approaches; (k) applicability in analysis of multiple compounds in select

  6. Professional Development for Researchers in Solid Earth Science Evolved to Include Scientific and Educational Content

    NASA Astrophysics Data System (ADS)

    Eriksson, S. C.; Arrowsmith, R.; Olds, S. E.

    2011-12-01

    Integrated measures of crustal deformation provide valuable insight about tectonic and human-induced processes for scientists and educators alike. UNAVCO in conjunction with EarthScope initiated a series of short courses for researchers to learn the processing and interpretation of data from new technologies such as high precision GPS, Strainmeter, InSar and LiDAR that provide deformation information relevant to many geoscience sub-disciplines. Intensive short courses of a few days and the widespread availability of processed data through large projects such as EarthScope and GEON enable more geoscientists to incorporate these data into diverse projects. Characteristics of the UNAVCO Short Course Series, reaching over 400 participants since 2005, include having short course faculty who have pioneered development of each technology; open web-access to course materials; processing software installed on class-ready computers; no course fees; scholarships for students, post-doctoral fellows, and emerging faculty when needed; formative evaluation of the courses; community-based decisions on topics; and recruitment of participants across relevant geoscience disciplines. In 2009, when EarthScope airborne LiDAR data became available to the public through OpenTopographhy, teaching materials were provided to these researchers to incorporate the latest technologies into teaching. Multiple data sets across technologies have been developed with instructions on how to access the various data sets and incorporate them into geological problem sets. Courses in GPS, airborne LiDAR, strainmeter, and InSAR concentrate on data processing with examples of various geoscience applications. Ground-based LiDAR courses also include data acquisition. Google Earth is used to integrate various forms of data in educational applications. Various types of EarthScope data can now be used by a variety of geoscientists, and the number of scientists who have the skills and tools to use these various

  7. 77 FR 43118 - Solicitation for a Cooperative Agreement-Development of a Series of Publications for the Evidence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ...The National Institute of Corrections (NIC) Community Services Division is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement with NIC for up to 18 months beginning in October 2012. Work under this cooperative agreement is part of a larger NIC initiative, Evidence-Based Decision Making (EBDM) in Local Criminal Justice Systems. Work under this......

  8. Inclusion in Infant/Toddler Child Development Settings: More than Just Including

    ERIC Educational Resources Information Center

    Parlakian, Rebecca

    2012-01-01

    "Inclusion" has long been a term used to describe the practice of including a child with special needs in age-appropriate general education classes in their home schools. Increasingly, the term is being used to describe the process of including very young children--infants and toddlers--with special needs in a setting comprised mostly of children…

  9. A new market risk model for cogeneration project financing---combined heat and power development without a power purchase agreement

    NASA Astrophysics Data System (ADS)

    Lockwood, Timothy A.

    Federal legislative changes in 2006 no longer entitle cogeneration project financings by law to receive the benefit of a power purchase agreement underwritten by an investment-grade investor-owned utility. Consequently, this research explored the need for a new market-risk model for future cogeneration and combined heat and power (CHP) project financing. CHP project investment represents a potentially enormous energy efficiency benefit through its application by reducing fossil fuel use up to 55% when compared to traditional energy generation, and concurrently eliminates constituent air emissions up to 50%, including global warming gases. As a supplemental approach to a comprehensive technical analysis, a quantitative multivariate modeling was also used to test the statistical validity and reliability of host facility energy demand and CHP supply ratios in predicting the economic performance of CHP project financing. The resulting analytical models, although not statistically reliable at this time, suggest a radically simplified CHP design method for future profitable CHP investments using four easily attainable energy ratios. This design method shows that financially successful CHP adoption occurs when the average system heat-to-power-ratio supply is less than or equal to the average host-convertible-energy-ratio, and when the average nominally-rated capacity is less than average host facility-load-factor demands. New CHP investments can play a role in solving the world-wide problem of accommodating growing energy demand while preserving our precious and irreplaceable air quality for future generations.

  10. Higher Education Development Training. Agreement Between the United States of America and Indonesia. Signed at Jakarta, October 28, 1976. Treaties and Other International Acts Series 8759.

    ERIC Educational Resources Information Center

    Department of State, Washington, DC.

    An agreement for a loan granted by the United States to Indonesia through the Agency for International Development (AID) for higher education development training is described. The assistance to certain educational institutions is designed to assist in the financing of advanced training, upgrading and development of the faculties, administrations,…

  11. Structured interview for mild traumatic brain injury after military blast: inter-rater agreement and development of diagnostic algorithm.

    PubMed

    Walker, William C; Cifu, David X; Hudak, Anne M; Goldberg, Gary; Kunz, Richard D; Sima, Adam P

    2015-04-01

    The existing gold standard for diagnosing a suspected previous mild traumatic brain injury (mTBI) is clinical interview. But it is prone to bias, especially for parsing the physical versus psychological effects of traumatic combat events, and its inter-rater reliability is unknown. Several standardized TBI interview instruments have been developed for research use but have similar limitations. Therefore, we developed the Virginia Commonwealth University (VCU) retrospective concussion diagnostic interview, blast version (VCU rCDI-B), and undertook this cross-sectional study aiming to 1) measure agreement among clinicians' mTBI diagnosis ratings, 2) using clinician consensus develop a fully structured diagnostic algorithm, and 3) assess accuracy of this algorithm in a separate sample. Two samples (n = 66; n = 37) of individuals within 2 years of experiencing blast effects during military deployment underwent semistructured interview regarding their worst blast experience. Five highly trained TBI physicians independently reviewed and interpreted the interview content and gave blinded ratings of whether or not the experience was probably an mTBI. Paired inter-rater reliability was extremely variable, with kappa ranging from 0.194 to 0.825. In sample 1, the physician consensus prevalence of probable mTBI was 84%. Using these diagnosis ratings, an algorithm was developed and refined from the fully structured portion of the VCU rCDI-B. The final algorithm considered certain symptom patterns more specific for mTBI than others. For example, an isolated symptom of "saw stars" was deemed sufficient to indicate mTBI, whereas an isolated symptom of "dazed" was not. The accuracy of this algorithm, when applied against the actual physician consensus in sample 2, was almost perfect (correctly classified = 97%; Cohen's kappa = 0.91). In conclusion, we found that highly trained clinicians often disagree on historical blast-related mTBI determinations. A fully structured interview

  12. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities, and Bibliography. Revised.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.; Long, Alison T.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population matters. The document describes 15 class sessions which integrate information for sociology, anthropology, psychology, biology, animal behavior, and education. Topics include the history of human…

  13. Development of electromagnetic cascades in the atmosphere including the Landau-Pomeranchuk-Migdal effect

    NASA Technical Reports Server (NTRS)

    Streitmatter, R. E.; Stephens, S. A.

    1985-01-01

    Numerical solutions have been obtained for the one-dimensional atmospheric electromagnetic cascade diffusion equations, including the Landau-Pomeranchuk-Migdal and screening effects. Spectra produced by primary gamma rays of various energies are given at a number of deths in the atmosphere.

  14. Use of Student Experiments for Teaching Embedded Software Development Including HW/SW Co-Design

    ERIC Educational Resources Information Center

    Mitsui, H.; Kambe, H.; Koizumi, H.

    2009-01-01

    Embedded systems have been applied widely, not only to consumer products and industrial machines, but also to new applications such as ubiquitous or sensor networking. The increasing role of software (SW) in embedded system development has caused a great demand for embedded SW engineers, and university education for embedded SW engineering has…

  15. Including Curriculum Focus in Mathematics Professional Development for Middle-School Mathematics Teachers

    ERIC Educational Resources Information Center

    Patel, Nimisha; Franco, Suzanne; Miura, Yoko; Boyd, Brian

    2012-01-01

    This paper examines professional development workshops focused on Connected Math, a particular curriculum utilized or being considered by the middle-school mathematics teachers involved in the study. The hope was that as teachers better understood the curriculum used in their classrooms, i.e., Connected Math, they would simultaneously deepen their…

  16. Androgen action during male sex differentiation includes suppression of cranial suspensory ligament development.

    PubMed

    Emmen, J M; McLuskey, A; Grootegoed, J A; Brinkmann, A O

    1998-05-01

    The cranial suspensory ligament is located on the border of the cranial (mesonephric) mesentery in adult female mammals, which runs between the cranial pole of the internal genitalia and the dorsal abdominal wall. Absence of the cranial suspensory ligament in male mammals depends upon exposure of its primordium to fetal testicular androgens and is a prerequisite for testis descent. Female rats were exposed to 5alpha-dihydrotestosterone propionate at different stages of genital development, and cranial suspensory ligament development was studied in neonatal and in adult animals. Androgens suppressed cranial suspensory ligament development when exposure started during the early stages of genital development, until day 19 postconception (pc). Androgen receptor expression was immunohistochemically detected in the cranial mesentery of both sexes from day 16 pc onwards. A decrease of androgen receptor expression in female fetuses from day 18 pc onwards coincided with the appearance of a differentiated cranial suspensory ligament, as evidenced by the expression of two cell differentiation markers: alpha-smooth muscle (alpha-SM) actin and desmin. alpha-SM actin was located on the outer border of the cranial mesentery of both sexes at day 17 pc, and expression increased only in female fetuses. On day 19 pc, desmin expression was also detectable in the a-SM actin-positive cells. Proliferation and apoptosis indices of cells in the cranial mesentery, as analysed by 5'-bromodeoxyuridine incorporation and by detection of DNA strand breaks (TUNEL method) respectively, did not show any difference between the sexes, neither on day 17 nor on day 18 pc. Since primordial cells of the cranial suspensory ligament highly express the androgen receptor during the period of gestation when androgens can suppress cranial suspensory development, altered morphogenesis of these cells may be a direct consequence of androgen action. PMID:9647559

  17. With Development, List Recall Includes More Chunks, Not Just Larger Ones

    PubMed Central

    Cowan, Nelson; Hismjatullina, Anna; AuBuchon, Angela M.; Saults, J. Scott; Horton, Neil; Leadbitter, Kathy; Towse, John

    2011-01-01

    The nature of the childhood development of immediate recall has been difficult to determine. There could be a developmental increase in either the number of chunks held in working memory or the use of grouping to make the most of a constant capacity. In 3 experiments with children in the early elementary school years and adults, we show that improvements in the immediate recall of word and picture lists come partly from increases in the number of chunks of items retained in memory. This finding was based on a distinction between access to a studied group of items (i.e., recall of at least 1 item from the group) and completion of the accessed group (i.e., the proportion of the items recalled from the group). Access rates increased with age, even with statistical controls for completion rates, implicating development of capacity in chunks. PMID:20822227

  18. Optimization of the weekly operation of a multipurpose hydroelectric development, including a pumped storage plant

    NASA Astrophysics Data System (ADS)

    Popa, R.; Popa, F.; Popa, B.; Zachia-Zlatea, D.

    2010-08-01

    It is presented an optimization model based on genetic algorithms for the operation of a multipurpose hydroelectric power development consisting in a pumped storage plant (PSP) with weekly operation cycle. The lower reservoir of the PSP is supplied upstream from a peak hydropower plant (HPP) with a large reservoir and supplies the own HPP which provides the required discharges towards downstream. Under these conditions, the optimum operation of the assembly consisting in 3 reservoirs and hydropower plants becomes a difficult problem if there are considered the restrictions as regards: the gradients allowed for the reservoirs filling/emptying, compliance with of a long-term policy of the upper reservoir from the hydroelectric development and of the weekly cycle for the PSP upper reservoir, correspondence between the power output/consumption in the weekly load schedule, turning to account of the water resource at maximum overall efficiencies, etc. Maximization of the net energy value (generated minus consumed) was selected as performance function of the model, considering the differentiated price of the electric energy over the week (working or weekend days, peak, half-peak or base hours). The analysis time step was required to be of 3 hours, resulting a weekly horizon of 56 steps and 168 decision variables, respectively, for the 3 HPPs of the system. These were allowed to be the flows turbined at the HPP and the number of working hydrounits at PSP, on each time step. The numerical application has considered the guiding data of Fantanele-Tarnita-Lapustesti hydroelectric development. Results of various simulations carried out proved the qualities of the proposed optimization model, which will allow its use within a decisional support program for such a development.

  19. Applications and development of BitClean technology including selective nanoparticle manipulation

    NASA Astrophysics Data System (ADS)

    Robinson, Tod; Brinkley, David; White, Roy; LeClaire, Jeff; Archuletta, Michael; Bozak, Ron; Yi, Daniel

    2012-06-01

    The technology to selectively remove nanoparticles from a photomask surface by adhering it to an AFM tip (BitClean) first introduced with the Merlin® nanomachining mask repair platform has been successfully integrated in numerous mask house production centers across the globe over the last two years. One outstanding request for development from customers has been to develop the capability to not only selectively remove nanoparticles from a target surface, but to also redeposit in another target region. This paper reviews the preliminary work done to develop this capability with particular emphasis on its potential applications in creating realistic nanoparticle inspection sites for KLA systems at critical pattern print locations as well as the accumulation of trace amounts of contaminates for better compositional and print-impact analysis. There is also a feasibility study of new ultra-high aspect ratio (AR > 1.5) NanoBits for future BitClean process applications. The potential for these capabilities to be adapted for new applications will be examined for future work as well as a detailed parametric process analysis with the goal of showing how to make significant improvements in BitClean PRE.

  20. The development of intermittent turbulence on a swept attachment line including the effects of compressibility

    NASA Astrophysics Data System (ADS)

    Poll, D. I. A.

    1983-02-01

    A model of the boundary layer transition process at an infinite swept attachment line under incompressible flow conditions and in the presence of a gross upstream disturbance is developed. The approach adopted is based upon the spot concepts of Emmons which are well established for transition on a flat plate. An extension to compressible flow situations is made by means of a simple transformation which reduces the process to an equivalent incompressible form. A new criterion for predicting the onset of attachment-line transition is proposed

  1. States and compacts: Issues and events affecting facility development efforts, including the Barnwell opening

    SciTech Connect

    Larson, G.S.

    1995-12-31

    Ten years have passed since the first regional low-level radioactive waste compacts received Congressional consent and initiated their efforts to develop new disposal capacity. During these 10 years, both significant achievements and serious setbacks have marked our efforts and affect our current outlook. Recent events in the waste marketplace, particularly in the operating status of the Barnwell disposal facility, have now raised legitimate questions about the continued rationale for the regional framework that grew out of the original legislation enacted by Congress in 1980. At the same time, licensing activities for new regional disposal facilities are under way in three states, and a fourth awaits the final go-ahead to begin construction. Uncertainty over the meaning and reliability of the marketplace events makes it difficult to gauge long-term implications. In addition, differences in the status of individual state and compact facility development efforts lead to varying assessments of the influence these events will, or should, have on such efforts.

  2. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS... What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

  3. Development of a new fertility prediction model for stallion semen, including flow cytometry.

    PubMed

    Barrier Battut, I; Kempfer, A; Becker, J; Lebailly, L; Camugli, S; Chevrier, L

    2016-09-01

    Several laboratories routinely use flow cytometry to evaluate stallion semen quality. However, objective and practical tools for the on-field interpretation of data concerning fertilizing potential are scarce. A panel of nine tests, evaluating a large number of compartments or functions of the spermatozoa: motility, morphology, viability, mitochondrial activity, oxidation level, acrosome integrity, DNA integrity, "organization" of the plasma membrane, and hypoosmotic resistance, was applied to a population of 43 stallions, 33 of which showing widely differing fertilities (19%-84% pregnancy rate per cycle [PRC]). Analyses were performed either within 2 hours after semen collection or after 24-hour storage at 4 °C in INRA96 extender, on three to six ejaculates for each stallion. The aim was to provide data on the distribution of values among said population, showing within-stallion and between-stallion variability, and to determine whether appropriate combinations of tests could evaluate the fertilizing potential of each stallion. Within-stallion repeatability, defined as intrastallion correlation (r = between-stallion variance/total variance) ranged between 0.29 and 0.84 for "conventional" variables (viability, morphology, and motility), and between 0.15 and 0.81 for "cytometric" variables. Those data suggested that analyzing six ejaculates would be adequate to characterize a stallion. For most variables, except those related to DNA integrity and some motility variables, results differed significantly between immediately performed analyses and analyses performed after 24 hours at 4 °C. Two "best-fit" combinations of variables were determined. Factorial discriminant analysis using a first combination of seven variables, including the polarization of mitochondria, acrosome integrity, DNA integrity, and hypoosmotic resistance, permitted exact determination of the fertility group for each stallion: fertile, that is, PRC higher than 55%; intermediate, that is, 45

  4. Distributed soil loss estimation system including ephemeral gully development and tillage erosion

    NASA Astrophysics Data System (ADS)

    Vieira, D. A. N.; Dabney, S. M.; Yoder, D. C.

    2015-03-01

    A new modelling system is being developed to provide spatially-distributed runoff and soil erosion predictions for conservation planning that integrates the 2D grid-based variant of the Revised Universal Soil Loss Equation, version 2 model (RUSLER), the Ephemeral Gully Erosion Estimator (EphGEE), and the Tillage Erosion and Landscape Evolution Model (TELEM). Digital representations of the area of interest (field, farm or entire watershed) are created using high-resolution topography and data retrieved from established databases of soil properties, climate, and agricultural operations. The system utilizes a library of processing tools (LibRaster) to deduce surface drainage from topography, determine the location of potential ephemeral gullies, and subdivide the study area into catchments for calculations of runoff and sheet-and-rill erosion using RUSLER. EphGEE computes gully evolution based on local soil erodibility and flow and sediment transport conditions. Annual tillage-induced morphological changes are computed separately by TELEM.

  5. Including Microbial Acclimation in Carbon Cycle Models: Letting Data Guide Model Development (Invited)

    NASA Astrophysics Data System (ADS)

    Mayes, M. A.; Wang, G.; Tang, G.; Xu, X.; Jagadamma, S.

    2013-12-01

    Carbon cycle models are traditionally parameterized with ad hoc soil pools, empirical decay constants and first-order decomposition as a function of substrate supply. Decomposition of vegetative and faunal inputs, however, involves enzymatically-facilitated depolymerization by the microbial community. Traditional soil models are calibrated to match existing distribution of soil carbon, but they are not parameterized to predict the response of soil carbon to climate change due to microbial community shifts or physiological changes, i.e., acclimation. As an example, we will show how the temperature sensitivity of carbon use efficiency can influence the decomposition of different substrates and affect the release of CO2 from soil organic matter. Acclimation to warmer conditions could also involve shifts in microbial community composition or function, e.g., fungi: bacteria ratio shift. Experimental data is needed to decide how to parameterize models to accommodate functional or compositional changes. We will explore documented cases of microbial acclimation to warming, discuss methods to include microbial acclimation in carbon cycle models, and explore the need for additional experimental data to validate the next generation of microbially-facilitated carbon cycle models.

  6. Current developments in avian influenza vaccines, including safety of vaccinated birds as food.

    PubMed

    Swayne, D E; Suarez, D L

    2007-01-01

    Until recently, most vaccines against avian influenza were based on oil-emulsified inactivated low- or high-pathogenicity viruses. Now, recombinant fowl pox and avian paramyxovirus type 1 vaccines with avian influenza H5 gene inserts (+ or - N1 gene insert) are available and licensed. New technologies might overcome existing limitations to make available vaccines that can be grown in tissue culture systems for more rapid production; provide optimized protection, as a result of closer genetic relations to field viruses; allow mass administration by aerosol, in drinking-water or in ovo; and allow easier strategies for identifying infected birds within vaccinated populations (DIVA). The technologies include avian influenza viruses with partial gene deletions, avian influenza-Newcastle disease virus chimeras, vectored vaccines such as adenoviruses and Marek's disease virus, and subunit vaccines. These new methods should be licensed only after their purity, safety, efficacy and potency against avian influenza viruses have been demonstrated, and, for live vectored vaccines, restriction of viral transmission to unvaccinated birds. Use of vaccines in countries affected by highly pathogenic avian influenza will not only protect poultry but will provide additional safety for consumers. Experimental studies have shown that birds vaccinated against avian influenza have no virus in meat and minimal amounts in eggs after HPAI virus challenge, and that replication and shedding from their respiratory and alimentary tracts is greatly reduced. PMID:18411943

  7. Ectopic Expression Screen Identifies Genes Affecting Drosophila Mesoderm Development Including the HSPG Trol

    PubMed Central

    Trisnadi, Nathanie; Stathopoulos, Angelike

    2014-01-01

    Gastrulation of the embryo involves coordinate cell movements likely supported by multiple signaling pathways, adhesion molecules, and extracellular matrix components. Fibroblast growth factors (FGFs) have a major role in Drosophila melanogaster mesoderm migration; however, few other inputs are known and the mechanism supporting cell movement is unclear. To provide insight, we performed an ectopic expression screen to identify secreted or membrane-associated molecules that act to support mesoderm migration. Twenty-four UAS insertions were identified that cause lethality when expressed in either the mesoderm (Twi-Gal4) or the ectoderm (69B-Gal4). The list was narrowed to a subset of 10 genes that were shown to exhibit loss-of-function mutant phenotypes specifically affecting mesoderm migration. These include the FGF ligand Pyramus, α-integrins, E-cadherin, Cueball, EGFR, JAK/STAT signaling components, as well as the heparan sulfate proteoglycan (HSPG) Terribly reduced optic lobes (Trol). Trol encodes the ortholog of mammalian HSPG Perlecan, a demonstrated FGF signaling cofactor. Here, we examine the role of Trol in Drosophila mesoderm migration and compare and contrast its role with that of Syndecan (Sdc), another HSPG previously implicated in this process. Embryos mutant for Trol or Sdc were obtained and analyzed. Our data support the view that both HSPGs function to support FGF-dependent processes in the early embryo as they share phenotypes with FGF mutants: Trol in terms of effects on mesoderm migration and caudal visceral mesoderm (CVM) migration and Sdc in terms of dorsal mesoderm specification. The differential roles uncovered for these two HSPGs suggest that HSPG cofactor choice may modify FGF-signaling outputs. PMID:25538103

  8. Development of Thermal Spraying and Coating Techniques by Using Thixotropic Slurries Including Metals and Ceramics Particles

    NASA Astrophysics Data System (ADS)

    Kirihara, S.; Itakura, Y.; Tasaki, S.

    2013-03-01

    Thermal nanoparticles coating and microlines patterning were newly developed as novel technologies to fabricate fine ceramics layers and geometrical intermetallics patterns for mechanical properties modulations of practical alloys substrates. Nanometer sized alumina particles were dispersed into acrylic liquid resins, and the obtained slurries were sputtered by using compressed air jet. The slurry mists could blow into the arc plasma with argon gas spraying. On stainless steels substrates, the fine surface layers with high wear resistance were formed. In cross sectional microstructures of the coated layers, micromater sized cracks or pores were not observed. Subsequently, pure aluminum particles were dispersed into photo solidified acrylic resins, and the slurry was spread on the stainless steel substrates by using a mechanical knife blade. On the substrates, microline patterns with self similar fractal structures were drawn and fixed by using scanning of an ultra violet laser beam. The patterned pure metal particles were heated by the argon arc plasma spray assisting, and the intermetallics or alloys phases with high hardness were created through reaction diffusions. Microstructures in the coated layers and the patterned lines were observed by using a scanning electron microscopy.

  9. Including operational data in QMRA model: development and impact of model inputs.

    PubMed

    Jaidi, Kenza; Barbeau, Benoit; Carrière, Annie; Desjardins, Raymond; Prévost, Michèle

    2009-03-01

    A Monte Carlo model, based on the Quantitative Microbial Risk Analysis approach (QMRA), has been developed to assess the relative risks of infection associated with the presence of Cryptosporidium and Giardia in drinking water. The impact of various approaches for modelling the initial parameters of the model on the final risk assessments is evaluated. The Monte Carlo simulations that we performed showed that the occurrence of parasites in raw water was best described by a mixed distribution: log-Normal for concentrations > detection limit (DL), and a uniform distribution for concentrations < DL. The selection of process performance distributions for modelling the performance of treatment (filtration and ozonation) influences the estimated risks significantly. The mean annual risks for conventional treatment are: 1.97E-03 (removal credit adjusted by log parasite = log spores), 1.58E-05 (log parasite = 1.7 x log spores) or 9.33E-03 (regulatory credits based on the turbidity measurement in filtered water). Using full scale validated SCADA data, the simplified calculation of CT performed at the plant was shown to largely underestimate the risk relative to a more detailed CT calculation, which takes into consideration the downtime and system failure events identified at the plant (1.46E-03 vs. 3.93E-02 for the mean risk). PMID:18957777

  10. Development and application of an assay for uranyl complexation by fungal metabolites, including siderophores.

    PubMed

    Renshaw, Joanna C; Halliday, Verity; Robson, Geoffrey D; Trinci, Anthony P J; Wiebe, Marilyn G; Livens, Francis R; Collison, David; Taylor, Robin J

    2003-06-01

    An assay to detect UO(2)(2+) complexation was developed based on the chrome azurol S (CAS) assay for siderophores (B. Schwyn and J. B. Neilands, Anal. Biochem. 160:47-56, 1987) and was used to investigate the ability of fungal metabolites to complex actinides. In this assay the discoloration of two dyed agars (one containing a CAS-Fe(3+) dye and the other containing a CAS-UO(2)(2+) dye) caused by ligands was quantified. The assay was tested by using the siderophore desferrioxamine B (DFO), and the results showed that there was a regular, reproducible relationship between discoloration and the amount of siderophore added. The ratio of the discoloration on the CAS-UO(2)(2+) agar to the discoloration on the CAS-Fe(3+) agar was independent of the amount of siderophore added. A total of 113 fungi and yeasts were isolated from three soil samples taken from the Peak District National Park. The fungi were screened for the production of UO(2)(2+) chelators by using the CAS-based assay and were also tested specifically for hydroxamate siderophore production by using the hydroxamate siderophore auxotroph Aureobacterium flavescens JG-9. This organism is highly sensitive to the presence of hydroxamate siderophores. However, the CAS-based assay was found to be less sensitive than the A. flavescens JG-9 assay. No significant difference between the results for each site for the two tests was found. Three isolates were selected for further study and were identified as two Pencillium species and a Mucor species. Our results show that the new assay can be effectively used to screen fungi for the production of UO(2)(2+) chelating ligands. We suggest that hydroxamate siderophores can be produced by mucoraceous fungi. PMID:12788768

  11. Developing core outcomes sets: methods for identifying and including patient-reported outcomes (PROs)

    PubMed Central

    2014-01-01

    Background Synthesis of patient-reported outcome (PRO) data is hindered by the range of available PRO measures (PROMs) composed of multiple scales and single items with differing terminology and content. The use of core outcome sets, an agreed minimum set of outcomes to be measured and reported in all trials of a specific condition, may improve this issue but methods to select core PRO domains from the many available PROMs are lacking. This study examines existing PROMs and describes methods to identify health domains to inform the development of a core outcome set, illustrated with an example. Methods Systematic literature searches identified validated PROMs from studies evaluating radical treatment for oesophageal cancer. PROM scale/single item names were recorded verbatim and the frequency of similar names/scales documented. PROM contents (scale components/single items) were examined for conceptual meaning by an expert clinician and methodologist and categorised into health domains. A patient advocate independently checked this categorisation. Results Searches identified 21 generic and disease-specific PROMs containing 116 scales and 32 single items with 94 different verbatim names. Identical names for scales were repeatedly used (for example, ‘physical function’ in six different measures) and others were similar (overlapping face validity) although component items were not always comparable. Based on methodological, clinical and patient expertise, 606 individual items were categorised into 32 health domains. Conclusion This study outlines a methodology for identifying candidate PRO domains from existing PROMs to inform a core outcome set to use in clinical trials. PMID:24495582

  12. Canadian seismic agreement

    SciTech Connect

    Wetmiller, R.J.; Lyons, J.A.; Shannon, W.E.; Munro, P.S.; Thomas, J.T.; Andrew, M.D.; Lamontagne, M.; Wong, C., Anglin, F.M.; Plouffe, M.; Lapointe, S.P.; Adams, J.; Drysdale, J.A. . Geophysics Div.)

    1990-04-01

    This is the twenty-first progress report under the agreement entitled Canadian Seismic Agreement between the US Nuclear Regulatory Commission (NRC) and the Canadian Commercial Corporation. Activities undertaken by the Geophysics Division of the Geological Survey of Canada (GD/GSC) during the period from July 01, 1988 to June 30, 1989 and supported in part by the NRC agreement are described below under four headings; Eastern Canada Telemetred Network and local network developments, Datalab developments, strong motion network developments and earthquake activity. In this time period eastern Canada experienced its largest earthquake in over 50 years. This earthquake, which has been christened the Saguenay earthquake, has provided a wealth of new data pertinent to earthquake engineering studies in eastern North America and is the subject of many continuing studies, which are presently being carried out at GD and elsewhere. 41 refs., 21 figs., 7 tabs.

  13. Canadian Seismic Agreement

    SciTech Connect

    Wetmiller, R.J.; Lyons, J.A.; Shannon, W.E.; Munro, P.S.; Thomas, J.T.; Andrew, M.D.; Lapointe, S.P.; Lamontagne, M.; Wong, C.; Anglin, F.M.; Adams, J.; Cajka, M.G.; McNeil, W.; Drysdale, J.A. )

    1992-05-01

    This is a progress report of work carried out under the terms of a research agreement entitled the Canadian Seismic Agreement'' between the US Nuclear Regulatory Commission (USNRC), the Canadian Commercial Corporation and the Geophysics Division of the Geological Survey of Canada (GD/GSC) during the period from July 01, 1989 to June 30, 1990. The Canadian Seismic Agreement'' supports generally the operation of various seismograph stations in eastern Canada and the collection and analysis of earthquake data for the purpose of mitigating seismic hazards in eastern Canada and the northeastern US. The specific activities carried out in this one-year period are summarized below under four headings; Eastern Canada Telemetred Network and local network developments, Datalab developments, strong-motion network developments and earthquake activity. During this period the first surface fault unequivocably determined to have accompanied a historic earthquake in eastern North America, occurred in northern Quebec.

  14. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  15. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  16. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  17. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  18. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  19. Mining Agreements with Indian Tribes

    ERIC Educational Resources Information Center

    Luebben, Tom

    1976-01-01

    The article discusses aspects of negotiating agreements for exploration, development, and mining of hard minerals on Indian Reservations. The agreements discussed are typical of copper agreements, but the general points under discussion are applicable to most hard minerals except for uranium, coal, and oil which are substantially different.…

  20. 76 FR 24291 - Proposed National Marketing Agreement Regulating Leafy Green Vegetables; Recommended Decision and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ...This recommended decision proposes the issuance of a marketing agreement (agreement) under the Agricultural Marketing Agreement Act of 1937 to cover the handling of fresh leafy green vegetables in the United States. Leafy green vegetables include lettuce, spinach, cabbage, and similar items. The proposed agreement would authorize the development and implementation of production and handling......

  1. 7 CFR Exhibit B to Subpart B of... - Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Grant Agreement (Public Bodies) for Site Development and/or Site Acquisition for Housing and/or Public Facilities and/or Services B Exhibit B to Subpart B of Part 1948 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE,...

  2. Development of laboratory and process sensors to monitor particle size distribution of industrial slurries (including shape characterization). Final technical report

    SciTech Connect

    Pendse, H.P.; Goetz, P.J.; Sharma, A.; Han, W; Bliss, T.C.

    1996-10-01

    The overall goal of the Particle Size Distribution (PSD) sensor projects was to develop and commercialize a sensor system capable of particle analysis, in terms of size distributions, using concentrated suspensions at high solids concentrations. The early research was focused on application of ultrasonic spectroscopy of inorganic pigment slurries (e.g. titanium dioxide) commonly encountered on paper industry. During the project prototypes were tested in both academic and industrial laboratories. Work also involved successful field tests of the on-line prototype at a pigment manufacturing facility. Pen Kem continued the work at its cost beyond the initial funded period from March `92 to September `94. The first project (DE- FC05-88CE40684), which began in September 1988, culminated in a commercial laboratory instrument, Pen Kem AcoustoPhor {trademark} 8000, put on the market in June 1993. The follow-on project was aimed at investigation of shape and orientation effects on ultrasonic spectroscopy. A new cooperative agreement was awarded in September 1994 (DE-FC05-94CE40005) to develop shape characterization capabilities deemed critical by the clay industry. This follow-on project achieved following successes: A theoretical model was developed to account for the effects of size-dependent aspect ratios of spheroid particles under different orientations on ultrasound attenuation spectra of concentrated slurries. The theoretical model was confirmed by laboratory tests on kaolin slurries. An algorithm was developed to simulate evolution of particle orientation fields in simple squeezing flows.

  3. Proteomic and metabolic analyses of early berry development in Vitis spp. including the period of ontogenic gain of resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Early development of grape berries is marked by several biological changes, including cell division and expansion, as berries initiate double sigmoid growth. In most genotypes, a significant gain of ontogenic resistance (OR) to some pathogens, including powdery mildew (PM) (Uncinula necator), also o...

  4. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS... What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System? (a) At a minimum, an IRR TFMMS system must include components for: (1) Uniformly...

  5. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS... What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System? (a) At a minimum, an IRR TFMMS system must include components for: (1) Uniformly...

  6. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS... What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System? (a) At a minimum, an IRR TFMMS system must include components for: (1) Uniformly...

  7. The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: a model of benefit-sharing arrangement in natural products drug discovery and development.

    PubMed

    Soejarto, D D; Gyllenhaal, C; Fong, H H S; Xuan, L T; Hiep, N T; Hung, N V; Bich, T Q; Southavong, B; Sydara, K; Pezzuto, J M

    2004-02-01

    The Convention on Biodiversity mandates a new approach to the discovery of natural product drugs, one that incorporates concepts of national ownership of genetic resources, intellectual property rights in traditional knowledge, and sharing of economic benefits with countries that are the source of new natural products. The International Cooperative Biodiversity Group (ICBG) program was established to support experimentation in implementation of the Convention through development and execution of international agreements for bioprospecting. The agreement of one such ICBG program, between the University of Illinois at Chicago and institutions in Vietnam and Laos, is presented here. The core elements contained in the single, five-way Memorandum of Agreement are the arrangements for intellectual property rights, treatment of informed consent, and plans for benefit-sharing (including the sharing of short- and long-term royalty benefits, capacity building, and community reciprocity). Program participants were able to develop a practical and flexible agreement that satisfies the wishes of all institutions that are parties to it. PMID:14987071

  8. Hawaii Energy Resource Overviews. Volume 4. Impact of geothermal resource development in Hawaii (including air and water quality)

    SciTech Connect

    Siegel, S.M.; Siegel, B.Z.

    1980-06-01

    The environmental consequences of natural processes in a volcanic-fumerolic region and of geothermal resource development are presented. These include acute ecological effects, toxic gas emissions during non-eruptive periods, the HGP-A geothermal well as a site-specific model, and the geothermal resources potential of Hawaii. (MHR)

  9. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... inter-modal facilities; (4) Information from other IRR Program management systems; (5) Future needs; and... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS... What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

  10. Metabolic Profiling of Developing Pear Fruits Reveals Dynamic Variation in Primary and Secondary Metabolites, Including Plant Hormones

    PubMed Central

    Oikawa, Akira; Otsuka, Takao; Nakabayashi, Ryo; Jikumaru, Yusuke; Isuzugawa, Kanji; Murayama, Hideki; Saito, Kazuki; Shiratake, Katsuhiro

    2015-01-01

    Metabolites in the fruits of edible plants include sweet sugars, visually appealing pigments, various products with human nutritional value, and biologically active plant hormones. Although quantities of these metabolites vary during fruit development and ripening because of cell division and enlargement, there are few reports describing the actual dynamics of these changes. Therefore, we applied multiple metabolomic techniques to identify the changes in metabolite levels during the development and ripening of pear fruits (Pyrus communis L. ‘La France’). We quantified and classified over 250 metabolites into six groups depending on their specific patterns of variation during development and ripening. Approximately half the total number of metabolites, including histidine and malate, accumulated transiently around the blooming period, during which cells are actively dividing, and then decreased either rapidly or slowly. Furthermore, the amounts of sulfur-containing amino acids also increased in pear fruits around 3–4 months after the blooming period, when fruit cells are enlarging, but virtually disappeared from ripened fruits. Some metabolites, including the plant hormone abscisic acid, accumulated particularly in the receptacle prior to blooming and/or fruit ripening. Our results show several patterns of variation in metabolite levels in developing and ripening pear fruits, and provide fundamental metabolomic data that is useful for understanding pear fruit physiology and enhancing the nutritional traits of new cultivars. PMID:26168247

  11. Studies and analyses of the management of scientific research and development, including implementation and application at NASA centers

    NASA Technical Reports Server (NTRS)

    Rubenstein, A. H.

    1975-01-01

    Summary results obtained through the Program of Research on the Management of Research and Development (POMRAD) were presented. The nature of the overall program and the specific projects undertaken were described. Statistical data is also given concerning the papers, publications, people, and major program areas associated with the program. The actual list of papers, names of doctoral and masters theses, and other details of the program are included as appendices.

  12. The Development of Suppletive and Affixal Tense and Agreement Morphemes in the L3 English of Basque-Spanish Bilinguals

    ERIC Educational Resources Information Center

    Garcia Mayo, Maria del Pilar; Villarreal Olaizola, Izaskun

    2011-01-01

    This article examines the third language (L3) developing morphology of 78 Basque-Spanish bilinguals following a Content and Language Integrated Learning (CLIL) program and a mainstream English as a foreign language (non-CLIL) program. The analysis of cross-sectional and longitudinal oral data shows that (1) the omission of inflection in the L3…

  13. 28 CFR 56.2 - Maintenance of records with respect to meetings held to develop voluntary agreements or plans of...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to the Department of Energy. The Department of Energy may, upon written notice to potential... International Energy Program. 56.2 Section 56.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) INTERNATIONAL ENERGY PROGRAM § 56.2 Maintenance of records with respect to meetings held to develop...

  14. 28 CFR 56.2 - Maintenance of records with respect to meetings held to develop voluntary agreements or plans of...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to the Department of Energy. The Department of Energy may, upon written notice to potential... International Energy Program. 56.2 Section 56.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) INTERNATIONAL ENERGY PROGRAM § 56.2 Maintenance of records with respect to meetings held to develop...

  15. 28 CFR 56.2 - Maintenance of records with respect to meetings held to develop voluntary agreements or plans of...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to the Department of Energy. The Department of Energy may, upon written notice to potential... International Energy Program. 56.2 Section 56.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) INTERNATIONAL ENERGY PROGRAM § 56.2 Maintenance of records with respect to meetings held to develop...

  16. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  17. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  18. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  19. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  20. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  1. Quick Guide: Power Purchase Agreements

    SciTech Connect

    2010-06-25

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  2. Should professional development include analyzing and coaching ways of speaking during inquiry-based science instruction in elementary classrooms?

    NASA Astrophysics Data System (ADS)

    van Zee, Emily H.

    2009-12-01

    In this commentary, I first consider what Oliveira defines inquiry-based science instruction to be. Next I discuss what the discourse practices are that he is advocating. Then I examine what he presents as evidence of changes in two teachers' discourse practices due to a summer institute and how their pragmatic awareness seems to have been enhanced through institute activities. Finally I ponder whether, when, how, and why professional development should include a focus on ways of speaking during inquiry-based science instruction.

  3. Agreement among 2 x 2 Agreement Indices.

    ERIC Educational Resources Information Center

    Conger, Anthony J.; Ward, David G.

    1984-01-01

    Sixteen measures of reliability for two-category nominal scales are compared. Upon correcting for chance agreement, there are only five distinct indices: Fleiss's modification of A-sub-1, the phi coefficient, Cohen's kappa, and two intraclass coefficients. Recommendations for choosing an agreement index are made based on definitions, magnitude,…

  4. U.S. Geological Survey and Microsoft Cooperative Research and Development Agreement: Geospatial Data Browsing and Retrieval Site on the World Wide Web

    USGS Publications Warehouse

    U.S. Geological Survey

    1998-01-01

    In May 1997, the U.S. Geological Survey (USGS) and the Microsoft Corporation of Redmond, Wash., entered into a cooperative research and development agreement (CRADA) to make vast amounts of geospatial data available to the general public through the Internet. The CRADA is a 36-month joint effort to develop a general, public-oriented browsing and retrieval site for geospatial data on the Internet. Specifically, Microsoft plans to (1) modify a large volume of USGS geospatial data so the images can be displayed quickly and easily over the Internet, (2) implement an easy-to-use interface for low-speed connections, and (3) develop an Internet Web site capable of servicing millions of users per day.

  5. U.S. Geological Survey and Microsoft Cooperative Research and Development Agreement: Geospatial Data Browsing and Retrieval Site on the World Wide Web

    USGS Publications Warehouse

    U.S. Geological Survey

    1999-01-01

    In May 1997, the U.S. Geological Survey (USGS) and the Microsoft Corporation of Redmond, Wash., entered into a cooperative research and development agreement (CRADA) to make vast amounts of geospatial data available to the general public through the Internet. The CRADA is a 36-month joint effort to develop a general, public-oriented browsing and retrieval site for geospatial data on the Internet. Specifically, Microsoft plans to (1) modify a large volume of USGS geospatial data so the images can be displayed quickly and easily over the Internet, (2) implement an easy-to-use interface for low-speed connections, and (3) develop an Internet Web site capable of servicing millions of users per day.

  6. 2 CFR 182.620 - Cooperative agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agreement. Cooperative agreement means an award of financial assistance that, consistent with 31 U.S.C. 6305... development agreements as defined in 15 U.S.C. 3710a. ... MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY...

  7. Development of Constraint Force Equation Methodology for Application to Multi-Body Dynamics Including Launch Vehicle Stage Seperation

    NASA Technical Reports Server (NTRS)

    Pamadi, Bandu N.; Toniolo, Matthew D.; Tartabini, Paul V.; Roithmayr, Carlos M.; Albertson, Cindy W.; Karlgaard, Christopher D.

    2016-01-01

    The objective of this report is to develop and implement a physics based method for analysis and simulation of multi-body dynamics including launch vehicle stage separation. The constraint force equation (CFE) methodology discussed in this report provides such a framework for modeling constraint forces and moments acting at joints when the vehicles are still connected. Several stand-alone test cases involving various types of joints were developed to validate the CFE methodology. The results were compared with ADAMS(Registered Trademark) and Autolev, two different industry standard benchmark codes for multi-body dynamic analysis and simulations. However, these two codes are not designed for aerospace flight trajectory simulations. After this validation exercise, the CFE algorithm was implemented in Program to Optimize Simulated Trajectories II (POST2) to provide a capability to simulate end-to-end trajectories of launch vehicles including stage separation. The POST2/CFE methodology was applied to the STS-1 Space Shuttle solid rocket booster (SRB) separation and Hyper-X Research Vehicle (HXRV) separation from the Pegasus booster as a further test and validation for its application to launch vehicle stage separation problems. Finally, to demonstrate end-to-end simulation capability, POST2/CFE was applied to the ascent, orbit insertion, and booster return of a reusable two-stage-to-orbit (TSTO) vehicle concept. With these validation exercises, POST2/CFE software can be used for performing conceptual level end-to-end simulations, including launch vehicle stage separation, for problems similar to those discussed in this report.

  8. NIAM-Deficient Mice Are Predisposed to the Development of Proliferative Lesions including B-Cell Lymphomas

    PubMed Central

    Reed, Sara M.; Hagen, Jussara; Muniz, Viviane P.; Rosean, Timothy R.; Borcherding, Nick; Sciegienka, Sebastian; Goeken, J. Adam; Naumann, Paul W.; Zhang, Weizhou; Tompkins, Van S.; Janz, Siegfried; Meyerholz, David K.; Quelle, Dawn E.

    2014-01-01

    Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor of cell proliferation that helps maintain chromosomal stability. It is a novel activator of the ARF-Mdm2-Tip60-p53 tumor suppressor pathway as well as other undefined pathways important for genome maintenance. To examine its predicted role as a tumor suppressor, we generated NIAM mutant (NIAMm/m) mice homozygous for a β-galactosidase expressing gene-trap cassette in the endogenous gene. The mutant mice expressed significantly lower levels of NIAM protein in tissues compared to wild-type animals. Fifty percent of aged NIAM deficient mice (14 to 21 months) developed proliferative lesions, including a uterine hemangioma, pulmonary papillary adenoma, and a Harderian gland adenoma. No age-matched wild-type or NIAM+/m heterozygous animals developed lesions. In the spleen, NIAMm/m mice had prominent white pulp expansion which correlated with enhanced increased reactive lymphoid hyperplasia and evidence of systemic inflammation. Notably, 17% of NIAM mutant mice had splenic white pulp features indicating early B-cell lymphoma. This correlated with selective expansion of marginal zone B cells in the spleens of younger, tumor-free NIAM-deficient mice. Unexpectedly, basal p53 expression and activity was largely unaffected by NIAM loss in isolated splenic B cells. In sum, NIAM down-regulation in vivo results in a significant predisposition to developing benign tumors or early stage cancers. These mice represent an outstanding platform for dissecting NIAM's role in tumorigenesis and various anti-cancer pathways, including p53 signaling. PMID:25393878

  9. The post-millennium development goals agenda: include 'end to all wars' as a public health goal!

    PubMed

    Jayasinghe, Saroj

    2014-09-01

    The process of identifying global post-millennium development goals (post-MDGs) has begun in earnest. Consensus is emerging in certain areas (e.g. eliminating poverty) and conflicts and violence are recognized as key factors that retard human development. However, current discussions focus on tackling intra-state conflicts and individual-based violence and hardly mention eliminating wars as a goal. Wars create public health catastrophes. They kill, maim, displace and affect millions. Inter-state wars fuel intra-state conflicts and violence. The peace agenda should not be the monopoly of the UN Security Council, and the current consensus-building process setting the post-MDG agenda is a rallying point for the global community. The human rights approach will not suffice to eliminate wars, because few are fought to protect human rights. The development agenda should therefore commit to eliminating all wars by 2030. Targets to reduce tensions and discourage wars should be included. We should act now. PMID:24642595

  10. Development of a computer algorithm for the analysis of variable-frequency AC drives: Case studies included

    NASA Technical Reports Server (NTRS)

    Kankam, M. David; Benjamin, Owen

    1991-01-01

    The development of computer software for performance prediction and analysis of voltage-fed, variable-frequency AC drives for space power applications is discussed. The AC drives discussed include the pulse width modulated inverter (PWMI), a six-step inverter and the pulse density modulated inverter (PDMI), each individually connected to a wound-rotor induction motor. Various d-q transformation models of the induction motor are incorporated for user-selection of the most applicable model for the intended purpose. Simulation results of selected AC drives correlate satisfactorily with published results. Future additions to the algorithm are indicated. These improvements should enhance the applicability of the computer program to the design and analysis of space power systems.

  11. Development and Implementation of a Battery-Electric Light-Duty Class 2a Truck including Hybrid Energy Storage

    NASA Astrophysics Data System (ADS)

    Kollmeyer, Phillip J.

    This dissertation addresses two major related research topics: 1) the design, fabrication, modeling, and experimental testing of a battery-electric light-duty Class 2a truck; and 2) the design and evaluation of a hybrid energy storage system (HESS) for this and other vehicles. The work begins with the determination of the truck's peak power and wheel torque requirements (135kW/4900Nm). An electric traction system is then designed that consists of an interior permanent magnet synchronous machine, two-speed gearbox, three-phase motor drive, and LiFePO4 battery pack. The battery pack capacity is selected to achieve a driving range similar to the 2011 Nissan Leaf electric vehicle (73 miles). Next, the demonstrator electric traction system is built and installed in the vehicle, a Ford F150 pickup truck, and an extensive set of sensors and data acquisition equipment is installed. Detailed loss models of the battery pack, electric traction machine, and motor drive are developed and experimentally verified using the driving data. Many aspects of the truck's performance are investigated, including efficiency differences between the two-gear configuration and the optimal gear selection. The remainder focuses on the application of battery/ultracapacitor hybrid energy storage systems (HESS) to electric vehicles. First, the electric truck is modeled with the addition of an ultracapacitor pack and a dc/dc converter. Rule-based and optimal battery/ultracapacitor power-split control algorithms are then developed, and the performance improvements achieved for both algorithms are evaluated for operation at 25°C. The HESS modeling is then extended to low temperatures, where battery resistance increases substantially. To verify the accuracy of the model-predicted results, a scaled hybrid energy storage system is built and the system is tested for several drive cycles and for two temperatures. The HESS performance is then modeled for three variants of the vehicle design, including the

  12. The oil and gas joint operating agreement

    SciTech Connect

    Not Available

    1990-01-01

    This book covers the following topics: introduction to the AAPL model form operating agreement; property provisions of the operating agreement; Article 6---the drilling and development article; duties and obligations revisited---who bear what risk of loss; operator's liens; accounting procedure joint operations; insurance; taking gas in kind absent a balancing agreement; RMMLF Form 5 Gas Balancing Agreement; tax partnerships for nontax professionals; alternative agreement forms.

  13. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

    PubMed

    Hong, Eun-Gyoung; Jung, Dae Young; Ko, Hwi Jin; Zhang, Zhiyou; Ma, Zhexi; Jun, John Y; Kim, Jae Hyeong; Sumner, Andrew D; Vary, Thomas C; Gardner, Thomas W; Bronson, Sarah K; Kim, Jason K

    2007-12-01

    Although insulin resistance has been traditionally associated with type 2 diabetes, recent evidence in humans and animal models indicates that insulin resistance may also develop in type 1 diabetes. A point mutation of insulin 2 gene in Ins2(Akita) mice leads to pancreatic beta-cell apoptosis and hyperglycemia, and these mice are commonly used to investigate type 1 diabetes and complications. Since insulin resistance plays an important role in diabetic complications, we performed hyperinsulinemic-euglycemic clamps in awake Ins2(Akita) and wild-type mice to measure insulin action and glucose metabolism in vivo. Nonobese Ins2(Akita) mice developed insulin resistance, as indicated by an approximately 80% reduction in glucose infusion rate during clamps. Insulin resistance was due to approximately 50% decreases in glucose uptake in skeletal muscle and brown adipose tissue as well as hepatic insulin action. Skeletal muscle insulin resistance was associated with a 40% reduction in total GLUT4 and a threefold increase in PKCepsilon levels in Ins2(Akita) mice. Chronic phloridzin treatment lowered systemic glucose levels and normalized muscle insulin action, GLUT4 and PKCepsilon levels in Ins2(Akita) mice, indicating that hyperglycemia plays a role in insulin resistance. Echocardiography showed significant cardiac remodeling with ventricular hypertrophy that was ameliorated following chronic phloridzin treatment in Ins2(Akita) mice. Overall, we report for the first time that nonobese, insulin-deficient Ins2(Akita) mice develop type 2 diabetes phenotypes including peripheral and hepatic insulin resistance and cardiac remodeling. Our findings provide important insights into the pathogenesis of metabolic abnormalities and complications affecting type 1 diabetes and lean type 2 diabetes subjects. PMID:17911348

  14. Ultrasonic Data Display and Analysis System Developed (Including Fuzzy Logic Analysis) for the Windows-Based PC

    NASA Technical Reports Server (NTRS)

    Lovelace, Jeffrey J.; Cios, Kryzsztof J.; Roth, Don J.; cAO, wEI n.

    2001-01-01

    Post-Scan Interactive Data Display (PSIDD) III is a user-oriented Windows-based system that facilitates the display and comparison of ultrasonic contact measurement data obtained at NASA Glenn Research Center's Ultrasonic Nondestructive Evaluation measurement facility. The system is optimized to compare ultrasonic measurements made at different locations within a material or at different stages of material degradation. PSIDD III provides complete analysis of the primary waveforms in the time and frequency domains along with the calculation of several frequency-dependent properties including phase velocity and attenuation coefficient and several frequency-independent properties, like the cross correlation velocity. The system allows image generation on all the frequency-dependent properties at any available frequency (limited by the bandwidth used in the scans) and on any of the frequency-independent properties. From ultrasonic contact scans, areas of interest on an image can be studied with regard to underlying raw waveforms and derived ultrasonic properties by simply selecting the point on the image. The system offers various modes of indepth comparison between scan points. Up to five scan points can be selected for comparative analysis at once. The system was developed with Borland Delphi software (Visual Pascal) and is based on an SQL data base. It is ideal for the classification of material properties or the location of microstructure variations in materials. Along with the ultrasonic contact measurement software that it is partnered with, this system is technology ready and can be transferred to users worldwide.

  15. Laboratory Studies of the Reactive Chemistry and Changing CCN Properties of Secondary Organic Aerosol, Including Model Development

    SciTech Connect

    Scot Martin

    2013-01-31

    The chemical evolution of secondary-organic-aerosol (SOA) particles and how this evolution alters their cloud-nucleating properties were studied. Simplified forms of full Koehler theory were targeted, specifically forms that contain only those aspects essential to describing the laboratory observations, because of the requirement to minimize computational burden for use in integrated climate and chemistry models. The associated data analysis and interpretation have therefore focused on model development in the framework of modified kappa-Koehler theory. Kappa is a single parameter describing effective hygroscopicity, grouping together several separate physicochemical parameters (e.g., molar volume, surface tension, and van't Hoff factor) that otherwise must be tracked and evaluated in an iterative full-Koehler equation in a large-scale model. A major finding of the project was that secondary organic materials produced by the oxidation of a range of biogenic volatile organic compounds for diverse conditions have kappa values bracketed in the range of 0.10 +/- 0.05. In these same experiments, somewhat incongruently there was significant chemical variation in the secondary organic material, especially oxidation state, as was indicated by changes in the particle mass spectra. Taken together, these findings then support the use of kappa as a simplified yet accurate general parameter to represent the CCN activation of secondary organic material in large-scale atmospheric and climate models, thereby greatly reducing the computational burden while simultaneously including the most recent mechanistic findings of laboratory studies.

  16. Characterisation of the legume SERK-NIK gene superfamily including splice variants: Implications for development and defence

    PubMed Central

    2011-01-01

    Background SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) genes are part of the regulation of diverse signalling events in plants. Current evidence shows SERK proteins function both in developmental and defence signalling pathways, which occur in response to both peptide and steroid ligands. SERKs are generally present as small gene families in plants, with five SERK genes in Arabidopsis. Knowledge gained primarily through work on Arabidopsis SERKs indicates that these proteins probably interact with a wide range of other receptor kinases and form a fundamental part of many essential signalling pathways. The SERK1 gene of the model legume, Medicago truncatula functions in somatic and zygotic embryogenesis, and during many phases of plant development, including nodule and lateral root formation. However, other SERK genes in M. truncatula and other legumes are largely unidentified and their functions unknown. Results To aid the understanding of signalling pathways in M. truncatula, we have identified and annotated the SERK genes in this species. Using degenerate PCR and database mining, eight more SERK-like genes have been identified and these have been shown to be expressed. The amplification and sequencing of several different PCR products from one of these genes is consistent with the presence of splice variants. Four of the eight additional genes identified are upregulated in cultured leaf tissue grown on embryogenic medium. The sequence information obtained from M. truncatula was used to identify SERK family genes in the recently sequenced soybean (Glycine max) genome. Conclusions A total of nine SERK or SERK-like genes have been identified in M. truncatula and potentially 17 in soybean. Five M. truncatula SERK genes arose from duplication events not evident in soybean and Lotus. The presence of splice variants has not been previously reported in a SERK gene. Upregulation of four newly identified SERK genes (in addition to the previously described MtSERK1) in

  17. Cooperative agreement 926 (SETI Institute)

    NASA Astrophysics Data System (ADS)

    Marshall, John R.

    1996-01-01

    Research activities carried out as part of cooperative agreement 926 are summarized. A portable, field deployable X-ray diffractometer-spectrometer was developed that can analyze rock surfaces and loose granular materials without the need for sample acquisition or preparation. The device was deployed on the Russian Marsokhod rover at the NASA Ames Research Center. Techniques and technological innovations were developed that provide the basis for a new kind of X-ray source. In the area of x-ray analysis techniques, artificial diffraction spectra were created to determine how complex mineral mixtures can be analyzed by diffractometry when only broad fingerprint patterns emerge from the analyses. USML-2 tapes were analyzed. A preliminary, but successful computer code was developed to simulate the behavior of agglomerating granular matter as it may occur in martian dust storms. The model is based on dipole-dipole interactions. In the area of aeolian comminution, using a particle impelling crossbow device , it was possible to elucidate the processes involved in reptation sand transport likely to occur on Mars and Earth. A theoretical model was developed that relates the microscopic cratering mechanisms during saltation-reptation to the megascopic impact processes caused by meteorites. Abstracts of two conference papers as well as five short articles published or submitted for publication are included as attachments.

  18. REQUEST FOR APPLICATIONS FOR A COOPERATIVE AGREEMENT TO PROVIDE ASSISTANCE FOR CONDUCTING RESEARCH TO DEVELOP IMPROVED METHODS AND APPROACHES TO EMPOWER COMMUNITIES TO PARTICIPATE MORE EFFECTIVELY IN ENVIRONMENTAL CLEANUPS

    EPA Science Inventory

    The Environmental Protection Agency (EPA), Office of Research and Development, National Center for Environmental Assessment (NCEA) is issuing this Request for Applications (RFA) for cooperative agreements to provide assistance conducting research to stimulate advances in the scie...

  19. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  20. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  1. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  2. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  3. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  4. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  5. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  6. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  7. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  8. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  9. Cosmic X-ray Physics: Sounding rocket investigations of the diffuse X-ray background, including instrument development

    NASA Astrophysics Data System (ADS)

    McCammon, Dan

    We propose an investigation to improve our understanding of the Galactic diffuse X-ray background. The ultimate purpose of this is to determine the role of hot phases of the interstellar medium in mediating stellar feedback in star formation, in transport of metals, and in determining the structure and evolution of the Galaxy. It directly addresses SMD's astrophysics goal No. 2, to explore the origin and evolution of the galaxies, stars and planets that make up our universe. This work will involve a flight of an existing payload with small modifications in Woomera, South Australia, to observe the Galactic soft X-ray bulge and attempt to determine its nature and emission mechanisms. This flight should also either confirm or put strict upper limits on the "sterile neutrino" model for the 3.5 keV signal observed near the Galactic Center by XMM-Newton. Our investigation includes the development of thermal detectors with superconducting transition edge thermometers capable of 1-2 eV FWHM energy resolution in the 100-400 eV range with the intent of obtaining a scientifically useful spectrum on a sounding rocket flight of the emission from one million degree gas in this energy range. This will require a total area of 1-2 square centimeters for the detector array. To enable routine testing of such detectors in the lab and for necessary in-flight gain and resolution monitoring, we are trying to develop a pulsed-UV laser calibration source. In collaboration with Goddard Space Flight Center, we are investigating the practicality of waveguide-below-cutoff filters to provide the necessary attenuation of infrared radiation for these detectors while still allowing good x-ray transmission below 150 eV. The detectors, calibration source, filters, optimal high-rate pulse analysis and flight experience with the detector readouts are all relevant to future NASA major missions. The detectors we're working on for a low-energy sounding rocket flight would be an excellent match to what is

  10. Development of a Stochastic Inversion Tool To Optimize Agreement Between The Observed And Predicted Seismic Response To CO2 Injection/Migration in the Weyburn-Midale Project

    SciTech Connect

    Ramirez, A L; Hao, Y; White, D; Carle, S; Dyer, K; Yang, X; Mcnab, W; Foxall, W; Johnson, J

    2009-12-02

    During Phase 1 of the Weyburn Project (2000-2004), 4D reflection seismic data were used to map CO{sub 2} migration within the Midale reservoir, while an extensive fluid sampling program documented the geochemical evolution triggered by CO{sub 2}-brine-oil-mineral interactions. The aim of this task (3b.11) is to exploit these existing seismic and geochemical data sets, augmented by CO{sub 2}/H{sub 2}O injection and HC/H{sub 2}O production data toward optimizing the reservoir model and thereby improving site characterization and dependent predictions of long-term CO{sub 2} storage in the Weyburn-Midale reservoir. Our initial project activities have concentrated on developing a stochastic inversion method that will identify reservoir models that optimize agreement between the observed and predicted seismic response. This report describes the technical approach we have followed, the data that supports it, and associated implementation activities. The report fulfills deliverable D1 in the project's statement of work. Future deliverables will describe the development of the stochastic inversion tool that uses geochemical data to optimize the reservoir model.

  11. Mining agreements III

    SciTech Connect

    Not Available

    1991-01-01

    This book cover the following: Forms of mining agreements; Preliminary letter agreements; Acquisition of mineral interests involving securities; Partnership tax treatment in mining agreements; Non-tax consequences of partnerships under state law; Protection against joint venturers' liabilities; Joint venture decision making; Mining royalties; Commingling and unitization provisions; Indemnification and insurance provisions; Area of interest provision; Dispute resolution; and Non-participation and default provisions.

  12. The Bottom-up Move within Vygotsky's Zone of Proximal Development: A Pedagogical Application for Teaching Agreement in Spanish as a Foreign Language

    ERIC Educational Resources Information Center

    Escandon, Arturo; Sanz, Montserrat

    2011-01-01

    This paper presents the findings of a longitudinal study in which two instructional methods to teach agreement features to first-year university students specializing in Spanish in Japan are compared. On the one hand, the control group was exposed to the traditional top-down teaching of agreement paradigms and were instructed to practice them…

  13. Misinterpretations in agreement and agreement attraction.

    PubMed

    Patson, Nikole D; Husband, E Matthew

    2016-05-01

    It has been well established that subject-verb number agreement can be disrupted by local noun phrases that differ in number from the subject head noun phrase. In sentence production, mismatches in the grammatical number of the head and local noun phrases lead to agreement errors on the verb as in: the key to the cabinets are. Similarly, although ungrammaticality typically causes disruption in measures of sentence comprehension, the disruption is reduced when the local noun phrase has a plural feature. Using a forced-choice comprehension question method, we report two experiments that provide evidence that comprehenders were likely to misinterpret the number information on the head noun phrase when morphosyntactic number markings on the local noun phrase and verb did not match the head. These results are consistent with a growing body of research that suggests that comprehenders often arrive at a final interpretation of a sentence that is not faithful to the linguistic input. PMID:25624171

  14. Proposed Requirements-driven User-scenario Development Protocol for the Belmont Forum E-Infrastructure and Data Management Cooperative Research Agreement

    NASA Astrophysics Data System (ADS)

    Wee, B.; Car, N.; Percivall, G.; Allen, D.; Fitch, P. G.; Baumann, P.; Waldmann, H. C.

    2014-12-01

    The Belmont Forum E-Infrastructure and Data Management Cooperative Research Agreement (CRA) is designed to foster a global community to collaborate on e-infrastructure challenges. One of the deliverables is an implementation plan to address global data infrastructure interoperability challenges and align existing domestic and international capabilities. Work package three (WP3) of the CRA focuses on the harmonization of global data infrastructure for sharing environmental data. One of the subtasks under WP3 is the development of user scenarios that guide the development of applicable deliverables. This paper describes the proposed protocol for user scenario development. It enables the solicitation of user scenarios from a broad constituency, and exposes the mechanisms by which those solicitations are evaluated against requirements that map to the Belmont Challenge. The underlying principle of traceability forms the basis for a structured, requirements-driven approach resulting in work products amenable to trade-off analyses and objective prioritization. The protocol adopts the ISO Reference Model for Open Distributed Processing (RM-ODP) as a top level framework. User scenarios are developed within RM-ODP's "Enterprise Viewpoint". To harmonize with existing frameworks, the protocol utilizes the conceptual constructs of "scenarios", "use cases", "use case categories", and use case templates as adopted by recent GEOSS Architecture Implementation Project (AIP) deliverables and CSIRO's eReefs project. These constructs are encapsulated under the larger construct of "user scenarios". Once user scenarios are ranked by goodness-of-fit to the Belmont Challenge, secondary scoring metrics may be generated, like goodness-of-fit to FutureEarth science themes. The protocol also facilitates an assessment of the ease of implementing given user scenario using existing GEOSS AIP deliverables. In summary, the protocol results in a traceability graph that can be extended to coordinate

  15. Computers in Secondary Schools in Developing Countries: Costs and Other Issues (Including Original Data from South Africa and Zimbabwe).

    ERIC Educational Resources Information Center

    Cawthera, Andy

    This research is mainly concerned with the costs of computers in schools in developing countries. It starts with a brief overview of the information revolution and its consequences. It then briefly examines some of the arguments for the use of computers in schools in developing countries, before reviewing previous work undertaken on the costs of…

  16. Including Complexity, Heterogeneity and Vegetation Response Characteristics into Carbon Balance Assessments at Continental Scale: Stepwise Development of a Simulation Framework with the Bottom-Up Core Model PIXGRO

    NASA Astrophysics Data System (ADS)

    Tenhunen, J.; Geyer, R.; Owen, K.; Falge, E.; Reichstein, M.

    2005-12-01

    The cultural landscapes of the European continent are characterized by highly fragmented land cover, distributed along the gradient from extremely sparse, dry Mediterranean shrublands to sub-arctic wetlands and forests. In addition, several mountain systems, in particular the Alps, modify vegetation and land surface exchange characteristics. In the recently begun CARBOEUROPE project, energy, water and CO2 exchanges of selected ecosystem types are monitored via eddy covariance methods. The model PIXGRO is being developed to help relate measurements at flux tower sites to measurements carried out at larger scale and to CO2 exchange estimates obtained with atmospheric inversion techniques. The main question addressed in this modelling effort is how to efficiently include a spectrum of vegetation characteristics into carbon balance assessments at large scale and in such a way that the influence of local response on regional fluxes may be visualized and analyzed. Furthermore, the modelling attempts to demonstrate both strengths and weaknesses in existing ecosystem process information required to understand carbon balances. The model PIXGRO attempts to define continental distribution and controls on net ecosystem CO2 exchange for ca. 12 ecosystem types, including coniferous forest, deciduous forest, grassland, cropland (assumed dominated by grain crops), northern boreal mixed forest, tundra, wetlands, alpine forest, evergreen forest, evergreen shrubland, and Mediterranean oak woodland. The model uses a single layer canopy with two leaf classes (sun and shade) and a three layered rooting zone to estimate GPP, ecosystem respiration and overall ecosystem gas exchange. Maximum LAI is determined during each year from the MODIS LAI-product. In the case of grassland, crops, tundra and wetlands, classical growth routines estimate dynamic changes in the vegetation canopy. Soil/canopy coupling in response to drought reflects a root system hormonal signalling and is calibrated with

  17. Application Agreement and Integration Services

    NASA Technical Reports Server (NTRS)

    Driscoll, Kevin R.; Hall, Brendan; Schweiker, Kevin

    2013-01-01

    Application agreement and integration services are required by distributed, fault-tolerant, safety critical systems to assure required performance. An analysis of distributed and hierarchical agreement strategies are developed against the backdrop of observed agreement failures in fielded systems. The documented work was performed under NASA Task Order NNL10AB32T, Validation And Verification of Safety-Critical Integrated Distributed Systems Area 2. This document is intended to satisfy the requirements for deliverable 5.2.11 under Task 4.2.2.3. This report discusses the challenges of maintaining application agreement and integration services. A literature search is presented that documents previous work in the area of replica determinism. Sources of non-deterministic behavior are identified and examples are presented where system level agreement failed to be achieved. We then explore how TTEthernet services can be extended to supply some interesting application agreement frameworks. This document assumes that the reader is familiar with the TTEthernet protocol. The reader is advised to read the TTEthernet protocol standard [1] before reading this document. This document does not re-iterate the content of the standard.

  18. CHESS: ten years of research and development in consumer health informatics for broad populations, including the underserved.

    PubMed

    Gustafson, D H; Hawkins, R P; Boberg, E W; McTavish, F; Owens, B; Wise, M; Berhe, H; Pingree, S

    2001-01-01

    This paper reviews the research and development around a consumer health informatics system CHESS (The Comprehensive Health Enhancement Support System) developed and tested by the Center for Health Systems Research and Analysis at the University of Wisconsin. The review will place particular emphasis on what has been found with regard to the acceptance and use of such systems by high risk and underserved groups. PMID:11604968

  19. CHESS: 10 years of research and development in consumer health informatics for broad populations, including the underserved.

    PubMed

    Gustafson, David H; Hawkins, Robert P; Boberg, Eric W; McTavish, Fiona; Owens, Betta; Wise, Meg; Berhe, Haile; Pingree, Suzanne

    2002-11-12

    This paper reviews the research and development around a consumer health informatics system CHESS (The Comprehensive Health Enhancement Support System) developed and tested by the Center for Health Systems Research and Analysis at the University of Wisconsin. The review places particular emphasis on what has been found with regard to the acceptance and use of such systems by high risk and underserved groups. PMID:12414016

  20. Using Intervention Mapping to develop a programme to prevent sexually transmittable infections, including HIV, among heterosexual migrant men

    PubMed Central

    Wolfers, Mireille EG; van den Hoek, Caty; Brug, Johannes; de Zwart, Onno

    2007-01-01

    Background There is little experience with carefully developed interventions in the HIV/STI prevention field aimed at adult heterosexual target groups in the Netherlands. The ability to apply intervention development protocols, like Intervention Mapping, in daily practice outside of academia, is a matter of concern. An urgent need also exists for interventions aimed at the prevention of STI in migrant populations in the Netherlands. This article describes the theory and evidence based development of HIV/STI prevention interventions by the Municipal Public Health Service Rotterdam Area (MPHS), the Netherlands, for heterosexual migrant men with Surinamese, Dutch-Caribbean, Cape Verdean, Turkish and Moroccan backgrounds. Methods First a needs assessment was carried out. Then, a literature review was done, key figures were interviewed and seven group discussions were held. Subsequently, the results were translated into specific objectives ("change objectives") and used in intervention development for two subgroups: men with an Afro-Caribbean background and unmarried men with a Turkish and Moroccan background. A matrix of change objectives was made for each subgroup and suitable theoretical methods and practical strategies were selected. Culturally-tailored interventions were designed and were pre-tested among the target groups. Results This development process resulted in two interventions for specific subgroups that were appreciated by both the target groups and the migrant prevention workers. The project took place in collaboration with a university center, which provided an opportunity to get expert advice at every step of the Intervention Mapping process. At relevant points of the development process, migrant health educators and target group members provided advice and feedback on the draft intervention materials. Conclusion This intervention development project indicates that careful well-informed intervention development using Intervention Mapping is feasible in

  1. 25 CFR 115.420 - When developing a minor's distribution plan, what information must be considered and included in...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disbursement from the minor's account; (d) An evaluation of other resources, including parental income, that... recognized by the BIA as having control and custody of the minor; (4) An emancipated minor; and/or (5) Any... parent, the legal guardian, the person who has been recognized by the BIA as having control and...

  2. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  3. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  4. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  5. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  6. Non-Proliferation Agreements.

    ERIC Educational Resources Information Center

    Swalec, John J.

    1981-01-01

    Discusses five kinds of cooperative agreements established by the College of Lake County (IL): those with other community colleges/technical institutes; the military; business, industry, and organizations; secondary schools; and community and special interest groups. Pays particular attention to two kinds of agreements with other colleges. (CAM)

  7. Cooperative Agreements Study Report.

    ERIC Educational Resources Information Center

    Lawton, R. E.; Magruder, D.

    During the 1983 meeting of the Florida Legislature, action was taken to begin a systematic study of the level of cooperation between the Florida public schools K-12 program and the community and junior colleges. The goals and objectives of the Cooperative Agreements Study were to review and compile a list of the cooperative agreements and identify…

  8. 48 CFR 35.017-1 - Sponsoring agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.017-1 Sponsoring agreements. (a) In order... earnings (reserves) and the development of a plan for their use and disposition. (4) A prohibition against... various forms; it may be included in a contract between the Government and the FFRDC, or in another...

  9. 48 CFR 35.017-1 - Sponsoring agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.017-1 Sponsoring agreements. (a) In order... earnings (reserves) and the development of a plan for their use and disposition. (4) A prohibition against... various forms; it may be included in a contract between the Government and the FFRDC, or in another...

  10. 48 CFR 35.017-1 - Sponsoring agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.017-1 Sponsoring agreements. (a) In order... earnings (reserves) and the development of a plan for their use and disposition. (4) A prohibition against... various forms; it may be included in a contract between the Government and the FFRDC, or in another...

  11. University of Scranton: Master Agreement.

    ERIC Educational Resources Information Center

    Scranton Univ., PA.

    This document is the collective bargaining agreement between the University of Scranton and its faculty effective September 1, 1975 until August 31, 1976. Its provisions include all full-time faculty members associated with the Reading Clinic and Counseling Center, full-time faculty assigned to the Department of Physical Education, full-time…

  12. USA/FRG umbrella agreement for cooperation in gas-cooled reactor development: Subprogram plan for cooperation in AVR [Arbeitsgemeinschaft Versuchs Reaktor] Test Program

    SciTech Connect

    Cleveland, J C; Baxter, A M; Krueger, K

    1988-05-01

    This subprogram plan describes cooperative work related to the AVR Test Program. This cooperative work is being carried out under the USA/FRG Implementing Agreement for Cooperation in Gas-Cooled Reactor Development. Earlier cooperation in this area was conducted under the Project Work Statement (PWS) for the ORNL/KFA/AVR Cooperative Effort in HTR Physics, Performance and Safety. The purpose of the cooperation is to obtain experimental information from the AVR relevant to the performance and safety of modular gas-cooled reactors, and to compare measured results with predictions of analytical tools. The scope of the cooperation involves examining the behavior of the AVR under various planned test conditions pertinent to modular gas-cooled reactor performance. AVR test data will be utilized to help validate computational methods used in the areas of reactor physics, fission and activation product transport and plant transient response, and to help understand modular gas-cooled reactor safety behavior (e.g., fission product behavior, dust behavior, and thermofluid dynamic behavior).

  13. Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse-Shear Effects

    NASA Technical Reports Server (NTRS)

    McGowan, David M.

    1999-01-01

    The analytical formulation of curved-plate non-linear equilibrium equations including transverse-shear-deformation effects is presented. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Linearized, perturbed equilibrium equations (stability equations) that describe the response of the plate just after buckling occurs are derived. These equations are then modified to allow the plate reference surface to be located a distance z(sub c) from the centroidal surface. The implementation of the new theory into the VICONOPT exact buckling and vibration analysis and optimum design computer program is described. The terms of the plate stiffness matrix using both classical plate theory (CPT) and first-order shear-deformation plate theory (SDPT) are presented. The effects of in-plane transverse and in-plane shear loads are included in the in-plane stability equations. Numerical results for several example problems with different loading states are presented. Comparisons of analyses using both physical and tensorial strain measures as well as CPT and SDPT are made. The computational effort required by the new analysis is compared to that of the analysis currently in the VICONOPT program. The effects of including terms related to in-plane transverse and in-plane shear loadings in the in-plane stability equations are also examined. Finally, results of a design-optimization study of two different cylindrical shells subject to uniform axial compression are presented.

  14. Including Disabled Children in Learning: Challenges in Developing Countries. CREATE Pathways to Access. Research Monograph No. 36

    ERIC Educational Resources Information Center

    Croft, Alison

    2010-01-01

    This is an exploratory study suggesting ways of analysing challenges for developing countries in the move to greater inclusion of disabled children and young people in learning. The paper focuses on pedagogical challenges to realising more inclusive education. Pedagogy encompasses not only the practice of teaching and learning, but also the ideas…

  15. Early Literacy and Early Numeracy: The Value of Including Early Literacy Skills in the Prediction of Numeracy Development

    ERIC Educational Resources Information Center

    Purpura, David J.; Hume, Laura E.; Sims, Darcey M.; Lonigan, Cristopher J.

    2011-01-01

    The purpose of this study was to examine whether early literacy skills uniquely predict early numeracy skills development. During the first year of the study, 69 3- to 5-year-old preschoolers were assessed on the Preschool Early Numeracy Skills (PENS) test and the Test of Preschool Early Literacy Skills (TOPEL). Participants were assessed again a…

  16. Early literacy and early numeracy: the value of including early literacy skills in the prediction of numeracy development.

    PubMed

    Purpura, David J; Hume, Laura E; Sims, Darcey M; Lonigan, Christopher J

    2011-12-01

    The purpose of this study was to examine whether early literacy skills uniquely predict early numeracy skills development. During the first year of the study, 69 3- to 5-year-old preschoolers were assessed on the Preschool Early Numeracy Skills (PENS) test and the Test of Preschool Early Literacy Skills (TOPEL). Participants were assessed again a year later on the PENS test and on the Applied Problems and Calculation subtests of the Woodcock-Johnson III Tests of Achievement. Three mixed effect regressions were conducted using Time 2 PENS, Applied Problems, and Calculation as the dependent variables. Print Knowledge and Vocabulary accounted for unique variance in the prediction of Time 2 numeracy scores. Phonological Awareness did not uniquely predict any of the mathematics domains. The findings of this study identify an important link between early literacy and early numeracy development. PMID:21831396

  17. Development and flight evaluation of active controls in the L-1011. [including wing load alleviation and stability augmentation

    NASA Technical Reports Server (NTRS)

    Johnston, J. F.; Urie, D. M.

    1978-01-01

    Active controls in the Lockheed L-1011 for increased energy efficiency are discussed. Active wing load alleviation for extended span, increased aspect ratio, and active stability augmentation with a smaller tail for reduced drag and weight are among the topics considered. Flight tests of active wing load alleviation on the baseline aircraft and moving-base piloted simulation developing criteria for stability augmentation are described.

  18. DEVELOPMENT OF PLASTICITY MODEL USING NON ASSOCIATED FLOW RULE FOR HCP MATERIALS INCLUDING ZIRCONIUM FOR NUCLEAR APPLICATIONS

    SciTech Connect

    Michael V. Glazoff; Jeong-Whan Yoon

    2013-08-01

    In this report (prepared in collaboration with Prof. Jeong Whan Yoon, Deakin University, Melbourne, Australia) a research effort was made to develop a non associated flow rule for zirconium. Since Zr is a hexagonally close packed (hcp) material, it is impossible to describe its plastic response under arbitrary loading conditions with any associated flow rule (e.g. von Mises). As a result of strong tension compression asymmetry of the yield stress and anisotropy, zirconium displays plastic behavior that requires a more sophisticated approach. Consequently, a new general asymmetric yield function has been developed which accommodates mathematically the four directional anisotropies along 0 degrees, 45 degrees, 90 degrees, and biaxial, under tension and compression. Stress anisotropy has been completely decoupled from the r value by using non associated flow plasticity, where yield function and plastic potential have been treated separately to take care of stress and r value directionalities, respectively. This theoretical development has been verified using Zr alloys at room temperature as an example as these materials have very strong SD (Strength Differential) effect. The proposed yield function reasonably well models the evolution of yield surfaces for a zirconium clock rolled plate during in plane and through thickness compression. It has been found that this function can predict both tension and compression asymmetry mathematically without any numerical tolerance and shows the significant improvement compared to any reported functions. Finally, in the end of the report, a program of further research is outlined aimed at constructing tensorial relationships for the temperature and fluence dependent creep surfaces for Zr, Zircaloy 2, and Zircaloy 4.

  19. Development of sensitive and rapid analytical methodology for food analysis of 18 mycotoxins included in a total diet study.

    PubMed

    Beltrán, Eduardo; Ibáñez, María; Portolés, Tania; Ripollés, Cristina; Sancho, Juan Vicente; Yusà, Vicent; Marín, Silvia; Hernández, Félix

    2013-06-14

    A rapid and sensitive method for the determination of 18 mycotoxins in 24 different food matrices has been developed and validated. With the exception of beverages and oil samples, a simple extraction with acetonitrile:water 80:20 (0.1% formic acid) was applied. Fruit juice, wine and beer samples were simply diluted with water containing 0.1% formic acid. Oil samples were partitioned with acetonitrile/hexane in order to remove fats. Analyses were made by ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry with triple quadrupole. Validation was carried out in all selected matrices using blank samples spiked at two analyte concentrations. Extraction recoveries between 70 and 120% and relative standard deviations lower than 20% were obtained for the wide majority of analyte-matrix combinations. Matrix-matched calibration was used for a correct quantification in order to compensate for matrix effects. Limits of quantification were lower than maximum permitted levels for every regulated mycotoxin-matrix combination. The acquisition of three SRM transitions per compound allowed the unequivocal confirmation of positive samples, supported by the accomplishment of ion intensity ratios and retention time when compared with reference standards. The developed methodology was applied to the analysis of 240 samples within a total diet study performed at Comunidad Valenciana (Spain). The most frequently found mycotoxins were deoxynivalenol, fumonisin B1, ochratoxin A and zearalenone at low μg kg(-1) levels, mainly in bread, breakfast cereals and beer. PMID:23726098

  20. Let's Take it to the Clouds: The Potential of Educational Innovations, Including Blended Learning, for Capacity Building in Developing Countries.

    PubMed

    Marrinan, Hannah; Firth, Sonja; Hipgrave, David; Jimenez-Soto, Eliana

    2015-09-01

    In modern decentralised health systems, district and local managers are increasingly responsible for financing, managing, and delivering healthcare. However, their lack of adequate skills and competencies are a critical barrier to improved performance of health systems. Given the financial and human resource, constraints of relying on traditional face-to-face training to upskill a large and dispersed number of health managers, governments, and donors must look to exploit advances in the education sector. In recent years, education providers around the world have been experimenting with blended learning; that is, amalgamating traditional face-to-face education with web-based learning to reduce costs and enrol larger numbers of students. Access to improved information and communication technology (ICT) has been the major catalyst for such pedagogical innovations. We argue that with many developing countries already improving their ICT systems, the question is not whether but how to employ technology to facilitate the continuous professional development of district and local health managers in decentralised settings. PMID:26340485

  1. Development and evaluation of a new soil moisture and runoff parameterization for the CABLE LSM including subgrid-scale processes

    NASA Astrophysics Data System (ADS)

    Decker, Mark

    2015-12-01

    New conceptual parameterizations of subgrid-scale soil moisture, runoff generation, and groundwater are developed and tested in the offline version of the Community Atmosphere and Biosphere Land Exchange (CABLE) model. These developments are designed to address a known bias in CABLE: the excess simulation of mean evapotranspiration over most of the Northern Hemisphere and over most vegetation types at global scales. The inclusion of subgrid-scale soil moisture parameterizations and runoff generation processes largely mitigates the overestimation of evapotranspiration, and simultaneously improves the simulation of mean runoff. There are also pronounced improvements in total water storage anomalies as compared to various observationally derived estimates. It is shown that surface and subsurface runoff generation resulting from subgrid-scale soil moisture heterogeneity is necessary to accurately simulate the mean observed runoff and evapotranspiration. Surface runoff generation is largely responsible from reducing the mean evapotranspiration bias north of 30°N. We note that the inability of previous CABLE evaluation studies to demonstrate the need for subgrid-scale heterogeneity is likely due to only testing at flux tower site scales. Evaluating land models at point scale and catchment scale across a large range of climate and vegetation types is necessary to evaluate the contributions of processes that influence the model at various spatial scales. Flux tower data are therefore a necessary but insufficient constraint on land surface models.

  2. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota

    PubMed Central

    Cetinyurek Yavuz, Aysun; Ben-Amor, Kaouther; Roelofs, Mieke; Ishikawa, Eiji; Kubota, Hiroyuki; Swinkels, Sophie; Sakai, Takafumi; Oishi, Kenji; Kushiro, Akira; Knol, Jan

    2016-01-01

    Colonization of the infant gut is believed to be critically important for a healthy growth as it influences gut maturation, metabolic, immune and brain development in early life. Understanding factors that influence this process is important, since an altered colonization has been associated with a higher risk of diseases later in life. Fecal samples were collected from 108 healthy neonates in the first half year of life. The composition and functionality of the microbiota was characterized by measuring 33 different bacterial taxa by qPCR/RT qPCR, and 8 bacterial metabolites. Information regarding gender, place and mode of birth, presence of siblings or pets; feeding pattern and antibiotic use was collected by using questionnaires. Regression analysis techniques were used to study associations between microbiota parameters and confounding factors over time. Bacterial DNA was detected in most meconium samples, suggesting bacterial exposure occurs in utero. After birth, colonization by species of Bifidobacterium, Lactobacillus and Bacteroides was influenced by mode of delivery, type of feeding and presence of siblings, with differences found at species level and over time. Interestingly, infant-type bifidobacterial species such as B. breve or B. longum subsp infantis were confirmed as early colonizers apparently independent of the factors studied here, while B. animalis subsp. lactis presence was found to be dependent solely on the type of feeding, indicating that it might not be a common infant gut inhabitant. One interesting and rather unexpected confounding factor was gender. This study contributes to our understanding of the composition of the microbiota in early life and the succession process and the evolution of the microbial community as a function of time and events occurring during the first 6 months of life. Our results provide new insights that could be taken into consideration when selecting nutritional supplementation strategies to support the

  3. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota.

    PubMed

    Martin, Rocio; Makino, Hiroshi; Cetinyurek Yavuz, Aysun; Ben-Amor, Kaouther; Roelofs, Mieke; Ishikawa, Eiji; Kubota, Hiroyuki; Swinkels, Sophie; Sakai, Takafumi; Oishi, Kenji; Kushiro, Akira; Knol, Jan

    2016-01-01

    Colonization of the infant gut is believed to be critically important for a healthy growth as it influences gut maturation, metabolic, immune and brain development in early life. Understanding factors that influence this process is important, since an altered colonization has been associated with a higher risk of diseases later in life. Fecal samples were collected from 108 healthy neonates in the first half year of life. The composition and functionality of the microbiota was characterized by measuring 33 different bacterial taxa by qPCR/RT qPCR, and 8 bacterial metabolites. Information regarding gender, place and mode of birth, presence of siblings or pets; feeding pattern and antibiotic use was collected by using questionnaires. Regression analysis techniques were used to study associations between microbiota parameters and confounding factors over time. Bacterial DNA was detected in most meconium samples, suggesting bacterial exposure occurs in utero. After birth, colonization by species of Bifidobacterium, Lactobacillus and Bacteroides was influenced by mode of delivery, type of feeding and presence of siblings, with differences found at species level and over time. Interestingly, infant-type bifidobacterial species such as B. breve or B. longum subsp infantis were confirmed as early colonizers apparently independent of the factors studied here, while B. animalis subsp. lactis presence was found to be dependent solely on the type of feeding, indicating that it might not be a common infant gut inhabitant. One interesting and rather unexpected confounding factor was gender. This study contributes to our understanding of the composition of the microbiota in early life and the succession process and the evolution of the microbial community as a function of time and events occurring during the first 6 months of life. Our results provide new insights that could be taken into consideration when selecting nutritional supplementation strategies to support the

  4. PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors.

    PubMed

    Maleszewski, Joseph J; Larsen, Brandon T; Kip, Nefize Sertac; Castonguay, Mathieu C; Edwards, William D; Carney, J Aidan; Kipp, Benjamin R

    2014-08-01

    Cardiac myxoma usually occurs as a solitary mass, but occasionally develops as part of a familial syndrome, the Carney complex (CNC). Two thirds of CNC-associated cardiac myxomas exhibit mutations in PRKAR1A. PRKAR1A mutations occur in both familial and sporadic forms of CNC but have not been described in isolated (nonsyndromic) cardiac myxomas. A total of 127 consecutive cardiac myxomas surgically resected at Mayo Clinic (1993 to 2011) from 110 individuals were studied. Clinical, radiologic, and pathologic findings were reviewed. Of these, 103 patients had isolated cardiac myxomas, and 7 patients had the tumor as a component of CNC. Age and sex distributions were different for CNC (mean 26 y, range 14 to 44 y, 71% female) and non-CNC (mean 62 y, range 18 to 92 y, 63% female) patients. PRKAR1A immunohistochemical analysis (IHC) was performed, and myxoma cell reactivity was graded semiquantitatively. Bidirectional Sanger sequencing was performed in 3 CNC patients and 29 non-CNC patients, to test for the presence of mutations in all coding regions and intron/exon boundaries of the PRKAR1A gene. IHC staining showed that all 7 CNC cases lacked PRKAR1A antigenicity and that 33 (32%) isolated cardiac myxomas were similarly nonreactive. Of tumors subjected to sequencing analysis, 2 (67%) CNC myxomas and 9 (31%) non-CNC myxomas had pathogenic PRKAR1A mutations. No germline mutations were found in 4 non-CNC cases tested. PRKAR1A appears to play a role in the development of both syndromic and nonsyndromic cardiac myxomas. Routine IHC evaluation of cardiac myxomas for PRKAR1A expression may be useful in excluding a diagnosis of CNC. PMID:24618615

  5. PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2

    PubMed Central

    Wishart, G C; Bajdik, C D; Dicks, E; Provenzano, E; Schmidt, M K; Sherman, M; Greenberg, D C; Green, A R; Gelmon, K A; Kosma, V-M; Olson, J E; Beckmann, M W; Winqvist, R; Cross, S S; Severi, G; Huntsman, D; Pylkäs, K; Ellis, I; Nielsen, T O; Giles, G; Blomqvist, C; Fasching, P A; Couch, F J; Rakha, E; Foulkes, W D; Blows, F M; Bégin, L R; van't Veer, L J; Southey, M; Nevanlinna, H; Mannermaa, A; Cox, A; Cheang, M; Baglietto, L; Caldas, C; Garcia-Closas, M; Pharoah, P D P

    2012-01-01

    Background: Predict (www.predict.nhs.uk) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the prognostic effect of HER2 status in a new version (Predict+), and to compare its performance with the original Predict and Adjuvant!. Methods: The prognostic effect of HER2 status was based on an analysis of data from 10 179 breast cancer patients from 14 studies in the Breast Cancer Association Consortium. The hazard ratio estimates were incorporated into Predict. The validation study was based on 1653 patients with early-stage invasive breast cancer identified from the British Columbia Breast Cancer Outcomes Unit. Predicted overall survival (OS) and breast cancer-specific survival (BCSS) for Predict+, Predict and Adjuvant! were compared with observed outcomes. Results: All three models performed well for both OS and BCSS. Both Predict models provided better BCSS estimates than Adjuvant!. In the subset of patients with HER2-positive tumours, Predict+ performed substantially better than the other two models for both OS and BCSS. Conclusion: Predict+ is the first clinical breast cancer prognostication tool that includes tumour HER2 status. Use of the model might lead to more accurate absolute treatment benefit predictions for individual patients. PMID:22850554

  6. Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment

    PubMed Central

    Rastgou Talemi, Soheil; Kollarovic, Gabriel; Lapytsko, Anastasiya; Schaber, Jörg

    2015-01-01

    Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recently, persistent DNA damage associated with telomeres was reported as a new kind of DNA damage. We therefore extended existing versions of the TLK model by new categories of DNA damage and re-evaluated those models using extensive data. We subjected different versions of the TLK model to a rigorous model discrimination approach. This enabled us to robustly select a best approximating parsimonious model that can both recapitulate and predict transient and persistent DNA damage after ionizing radiation. Models and data argue for i) nonlinear dose-damage relationships, and ii) negligible saturation of repair kinetics even for high doses. Additionally, we show that simulated radiation-induced persistent telomere-associated DNA damage foci (TAF) can be used to predict excess relative risk (ERR) of developing secondary leukemia after fractionated radiotherapy. We suggest that TAF may serve as an additional measure to predict cancer risk after radiotherapy using high dose rates. This may improve predicting risk-dose dependency of ionizing radiation especially for long-term therapies. PMID:26359627

  7. Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment.

    PubMed

    Rastgou Talemi, Soheil; Kollarovic, Gabriel; Lapytsko, Anastasiya; Schaber, Jörg

    2015-01-01

    Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recently, persistent DNA damage associated with telomeres was reported as a new kind of DNA damage. We therefore extended existing versions of the TLK model by new categories of DNA damage and re-evaluated those models using extensive data. We subjected different versions of the TLK model to a rigorous model discrimination approach. This enabled us to robustly select a best approximating parsimonious model that can both recapitulate and predict transient and persistent DNA damage after ionizing radiation. Models and data argue for i) nonlinear dose-damage relationships, and ii) negligible saturation of repair kinetics even for high doses. Additionally, we show that simulated radiation-induced persistent telomere-associated DNA damage foci (TAF) can be used to predict excess relative risk (ERR) of developing secondary leukemia after fractionated radiotherapy. We suggest that TAF may serve as an additional measure to predict cancer risk after radiotherapy using high dose rates. This may improve predicting risk-dose dependency of ionizing radiation especially for long-term therapies. PMID:26359627

  8. 77 FR 58592 - Modified Norway Post Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ...The Commission is noticing a recently-filed Postal Service request to include a modified Norway Post Agreement within an existing competitive product. The modification includes an 18-month extension of the original agreement's term. This notice addresses procedural aspects of the...

  9. SORBENT DEVELOPMENT FOR MERCURY CONTROL. Final topical report including semiannual for January 1, 1998 through June 30, 1998.

    SciTech Connect

    David J. Hassett; Edwin S. Olson; Grant E. Dunham; Ramesh K. Sharma; Ronald C. Timpe; Stanley J. Miller

    1998-10-01

    The US Environmental Protection Agency (EPA) draft Mercury Study Report to Congress (1) estimated anthropogenic mercury emissions to be 253 tons/yr in the US, with the majority (216 tons/yr) from combustion sources. The three main combustion sources listed were coal (72 tons/yr), medical waste incinerators (65 tons/yr), and municipal waste combustors (64 tons/yr). The emissions from both medical waste incinerators and municipal waste combustors were recently regulated, which, together with the reduction of mercury in consumer products such as batteries and fluorescent lights, has already reduced the emissions from these sources, as stated in the final EPA Mercury Report to Congress (2). EPA now estimates total point-source mercury emissions to be 158 tons/yr, with coal remaining at 72 tons/yr, while medical waste incinerators are down to 16 tons/yr and municipal waste combustors are at 30 tons/yr. Coal is now the primary source of anthropogenic mercury emissions in the US, accounting for 46%. In addition, the use of coal in the US has been increasing every year and passed the 1-billion-ton-per-year mark for the first time in 1997 (3). At the current rate of increase, coal consumption would reach 1.4 billion tons annually by the year 2020. On a worldwide basis, the projected increase in coal usage over the next two decades in China, India, and Indonesia will dwarf the current US coal consumption level. Therefore, in the US coal will be the dominant source of mercury emissions and worldwide coal may be the cause of significantly increased mercury emissions unless an effective control strategy is implemented. However, much uncertainty remains over the most technically sound and cost-effective approach for reducing mercury emissions from coal-fired boilers, and a number of critical research needs will have to be met to develop better control (2).

  10. Cosmic X-ray Physics: A Suborbital Investigation of the Diffuse X-ray Background Including Instrumentation Development

    NASA Astrophysics Data System (ADS)

    McCammon, Dan

    We propose an investigation to improve our understanding of the Galactic diffuse X-ray background. The ultimate purpose of this is to determine the role of hot phases of the interstellar medium in mediating stellar feedback in star formation, in transport of metals, and in determining the structure and evolution of the Galaxy. This work will involve a flight of an existing payload with small modifications in Woomera, South Australia, to observe the Galactic soft X-ray bulge and attempt to determine its nature and emission mechanisms. It will also involve the development of detectors capable of 1-2 eV FWHM energy resolution in the 100-400 eV range with the intent of obtaining a scientifically useful spectrum on a sounding rocket flight of the emission from one million degree gas in this energy range. This will require a total area of 1-2 cm^2 for the detector array. With the collaboration and advice of microwave experts at the Goddard Space Flight Center, we will fabricate and test waveguide-below-cutoff filters to provide the necessary attenuation of infrared radiation for these detectors while still allowing relatively good x- ray transmission below 300 eV. The detectors, filters, and flight experience with the detector readouts are all relevant to future NASA major missions. The filters would be particularly valuable in allowing thermal detectors (microcalorimeters) similar to those used here in the X-ray range to be applied to the EUV and vacuum ultraviolet, where they offer large potential gains over existing detectors. These investigations will provide the primary training for our graduate students, and will involve a substantial number of undergraduates.

  11. Form 6 - gas balancing agreement

    SciTech Connect

    Not Available

    1990-01-01

    In 1988, a special Committee of the Rocky Mountain Mineral Law Foundation undertook a project to draft a model from gas balancing agreement. This project was initiated at the request of a number of Foundation members who felt that a model form gas balancing agreement would facilitate the negotiation of operating agreement, since gas balancing issues had become sticking points in the process. The Committee was composed of attorneys representing a wide cross-section of the oil and gas industry including both major and independent oil companies, production companies with interstate pipeline affiliates, and private practitioners. The Committee attempted to address the more controversial issues in gas balancing with optional provisions in the Form. To facilitate the negotiation process, the number of optional provisions was minimized. This form may be used as an Appendix to the new A.A.P.L. Form 610-1989 Model Form Operating Agreement. This book includes provision of this Form which are: Ownership of gas production; Balancing of production accounts; Cash balancing upon depletion; Deliverability tests; Nominations; Statements; Payment of taxes; Operating expenses; Overproducing allowable; Payment of leasehold burdens; Operator's liability; Successors and assigns; Audits; Arbitration; and Operator's fees.

  12. Effects of School Heads' and Teachers' Agreement with the Curriculum Reform on Curriculum Development Progress and Student Learning in Hong Kong

    ERIC Educational Resources Information Center

    Cheung, Alan C. K.; Wong, Ping Man

    2011-01-01

    Purpose: The purpose of this paper is to examine the progress of the curriculum reform in Hong Kong in the implementation phase from 2001-2006, with the agreement and support of heads and teachers on the reform. Design/methodology/approach: Survey questionnaires and focus group interviews were used to collect data from various stakeholders. A…

  13. FFTF Authorization Agreement

    SciTech Connect

    DAUTEL, W.A.

    2000-09-25

    The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently in the Fast Flux Test Facility (FFTF). Work must be accomplished in a manner that achieves high levels of quality while protecting the environment and the safety and health of workers and the public, and complying with applicable contractual and regulatory requirements. It is the intent of this Agreement to address those items of significant importance in establishing and supporting the FFTF Authorization Envelope, but this Agreement in no way alters the terms and conditions of the Project Hanford Management Contract (PHMC), Contract Number DE-AC06-96RL13200.

  14. 23 CFR 630.110 - Modification of original agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... unless specifically authorized by statute. (b) The STD may develop the modification of project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1) The... of officials from both the State and the FHWA and date executed. (c) The STD may use an...

  15. 23 CFR 630.110 - Modification of original agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... unless specifically authorized by statute. (b) The STD may develop the modification of project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1) The... of officials from both the State and the FHWA and date executed. (c) The STD may use an...

  16. 23 CFR 630.110 - Modification of original agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... unless specifically authorized by statute. (b) The STD may develop the modification of project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1) The... of officials from both the State and the FHWA and date executed. (c) The STD may use an...

  17. 23 CFR 630.110 - Modification of original agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... unless specifically authorized by statute. (b) The STD may develop the modification of project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1) The... of officials from both the State and the FHWA and date executed. (c) The STD may use an...

  18. 23 CFR 630.110 - Modification of original agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... unless specifically authorized by statute. (b) The STD may develop the modification of project agreement in a format acceptable to both the STD and the FHWA provided the following are included: (1) The... of officials from both the State and the FHWA and date executed. (c) The STD may use an...

  19. Agreement in cardiovascular risk rating based on anthropometric parameters

    PubMed Central

    Dantas, Endilly Maria da Silva; Pinto, Cristiane Jordânia; Freitas, Rodrigo Pegado de Abreu; de Medeiros, Anna Cecília Queiroz

    2015-01-01

    Objective To investigate the agreement in evaluation of risk of developing cardiovascular diseases based on anthropometric parameters in young adults. Methods The study included 406 students, measuring weight, height, and waist and neck circumferences. Waist-to-height ratio and the conicity index. The kappa coefficient was used to assess agreement in risk classification for cardiovascular diseases. The positive and negative specific agreement values were calculated as well. The Pearson chi-square (χ2) test was used to assess associations between categorical variables (p<0.05). Results The majority of the parameters assessed (44%) showed slight (k=0.21 to 0.40) and/or poor agreement (k<0.20), with low values of negative specific agreement. The best agreement was observed between waist circumference and waist-to-height ratio both for the general population (k=0.88) and between sexes (k=0.93 to 0.86). There was a significant association (p<0.001) between the risk of cardiovascular diseases and females when using waist circumference and conicity index, and with males when using neck circumference. This resulted in a wide variation in the prevalence of cardiovascular disease risk (5.5%-36.5%), depending on the parameter and the sex that was assessed. Conclusion The results indicate variability in agreement in assessing risk for cardiovascular diseases, based on anthropometric parameters, and which also seems to be influenced by sex. Further studies in the Brazilian population are required to better understand this issue. PMID:26466060

  20. FFTF Authorization Agreement

    SciTech Connect

    DAUTEL, W.A.

    2000-02-25

    The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently.

  1. Coefficients for Interrater Agreement.

    ERIC Educational Resources Information Center

    Zegers, Frits E.

    1991-01-01

    The degree of agreement between two raters rating several objects for a single characteristic can be expressed through an association coefficient, such as the Pearson product-moment correlation. How to select an appropriate association coefficient, and the desirable properties and uses of a class of such coefficients--the Euclidean…

  2. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... restoration cost-share agreements. (a) The restoration plan developed under § 625.13 forms the basis for the... agreement will: (1) Incorporate all portions of a restoration plan; (2) Be for a period of 10 years; (3... implementation of the approved conservation treatment identified in the restoration plan; and (8) Include...

  3. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... restoration cost-share agreements. (a) The restoration plan developed under § 625.13 forms the basis for the... agreement will: (1) Incorporate all portions of a restoration plan; (2) Be for a period of 10 years; (3... implementation of the approved conservation treatment identified in the restoration plan; and (8) Include...

  4. International trade agreements: a threat to tobacco control policy

    PubMed Central

    Shaffer, E; Brenner, J; Houston, T

    2005-01-01

    International covenants establish a role for governments in ensuring the conditions for human health and wellbeing, which has been recognised as a central human right. International trade agreements, conversely, prioritise the rights of corporations over health and human rights. International trade agreements are threatening existing tobacco control policies and restrict the possibility of implementing new controls. This situation is unrecognised by many tobacco control advocates in signatory nations, especially those in developing countries. Recent agreements on eliminating various trade restrictions, including those on tobacco, have expanded far beyond simply international movement of goods to include internal tobacco distribution regulations and intellectual property rules regulating advertising and labelling. Our analysis shows that to the extent trade agreements protect the tobacco industry, in itself a deadly enterprise, they erode human rights principles and contribute to ill health. The tobacco industry has used trade policy to undermine effective barriers to tobacco importation. Trade negotiations provide an unwarranted opportunity for the tobacco industry to assert its interests without public scrutiny. Trade agreements provide the industry with additional tools to obstruct control policies in both developed and developing countries and at every level. The health community should become involved in reversing these trends, and help promote additional measures to protect public health. PMID:16046697

  5. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  6. 76 FR 74060 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... geographic scope to include Sri Lanka, the United Arab Emirates, Indonesia, Korea, and Australia. Agreement... Agriculture Investment Export, Inc. Filing Party: Wade S. Hooker, Esquire, 21 Central Park W.; New York, NY 10024. Synopsis: The agreement authorizes Great White Fleet to charter space to Agriculture...

  7. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  8. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  9. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  10. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  11. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  12. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  13. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  14. Countries renew rescue agreement

    NASA Astrophysics Data System (ADS)

    Bush, Susan M.

    To insure long-term continuity for the international satellite search and rescue system, COSPAS/SARSAT, an intergovernmental agreement binding the four sponsoring nations to cooperate was signed July 1 in Paris. According to Russell Vollmers of the National Oceanic and Atmospheric Administration, the agreement is binding for 15 years, with an automatic extension.The system marked the fifth anniversary of its first rescue last year, when on September 10, 1982, three persons were rescued. Begun in the 1970s by NASA as an experiment, COSPAS/SARSAT (a Russian-English acronym) is now a cooperative project among the United States, Canada, France, and the Soviet Union. Its goal is to reduce the time required to rescue air and maritime distress victims and also to locate victims who otherwise may not be found, thus using the satellite system as a life-saving device.

  15. A probability-based formula for calculating interobserver agreement1

    PubMed Central

    Yelton, Ann R.; Wildman, Beth G.; Erickson, Marilyn T.

    1977-01-01

    Estimates of observer agreement are necessary to assess the acceptability of interval data. A common method for assessing observer agreement, per cent agreement, includes several major weaknesses and varies as a function of the frequency of behavior recorded and the inclusion or exclusion of agreements on nonoccurrences. Also, agreements that might be expected to occur by chance are not taken into account. An alternative method for assessing observer agreement that determines the exact probability that the obtained number of agreements or better would have occurred by chance is presented and explained. Agreements on both occurrences and nonoccurrences of behavior are considered in the calculation of this probability. PMID:16795541

  16. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  17. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  18. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each...

  19. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  20. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  1. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  2. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  3. Quick Guide: Power Purchase Agreements (Fact Sheet)

    SciTech Connect

    Not Available

    2011-07-01

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  4. 75 FR 78245 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... Shipping Container Lines Co. Ltd., China Shipping Container Lines (Hong Kong) Co. Ltd., and Compania Sud..., including China, Hong Kong, and Korea. Agreement No.: 012114. Title: POS/TSL Vessel Sharing...

  5. Quick Guide: Power Purchase Agreements (Fact Sheet)

    SciTech Connect

    Not Available

    2010-06-01

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  6. Cooperative monitoring of regional security agreements

    SciTech Connect

    Pregenzer, A.L.; Vannoni, M.; Biringer, K.L.

    1996-11-01

    This paper argues that cooperative monitoring plays a critical role in the implementation of regional security agreements and confidence building measures. A framework for developing cooperative monitoring options is proposed and several possibilities for relating bilateral and regional monitoring systems to international monitoring systems are discussed. Three bilateral or regional agreements are analyzed briefly to illustrate different possibilities. These examples illustrate that the relationship of regional or bilateral arms control or security agreements to international agreements depends on a number of factors: the overlap of provisions between regional and international agreements; the degree of interest in a regional agreement among the international community; efficiency in implementing the agreement; and numerous political considerations. Given the importance of regional security to the international community, regions should be encouraged to develop their own infrastructure for implementing regional arms control and other security agreements. A regional infrastructure need not preclude participation in an international regime. On the contrary, establishing regional institutions for arms control and nonproliferation could result in more proactive participation of regional parties in developing solutions for regional and international problems, thereby strengthening existing and future international regimes. Possible first steps for strengthening regional infrastructures are identified and potential technical requirements are discussed.

  7. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES...

  8. 24 CFR 585.402 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Grant agreement. 585.402 Section 585.402 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES...

  9. 24 CFR 582.400 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Grant agreement. 582.400 Section 582.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES SHELTER...

  10. Service Level Agreements in BREIN

    NASA Astrophysics Data System (ADS)

    Koller, Bastian; Frutos, Henar Munoz; Laria, Giuseppe

    With electronic business (eBusiness) becoming ubiquitous, the traditional ways of doing commerce need to be changed or completely replaced to support the end users effectively in performing their business. This includes especially the representation of business relationships with an electronic format to allow for automated processing of the respective parts of e.g. contractual obligations. One prominent representation tool are Service Level Agreements. Conceptually established as paper representation to describe parts of contracts of telecom operators, SLAs have become a research topic in the ICT domain now since several years.

  11. University-Industry Teaming Agreements.

    ERIC Educational Resources Information Center

    Stombler, Milton P.

    1989-01-01

    The use of preaward agreements between the industry and the university collaborating to seek external funding, particularly from government sources, is examined. The agreements describe the parties' obligations in seeking funding and lay the groundwork for subsequent research agreements. Elements of such agreements are discussed to raise awareness…

  12. Cooperative monitoring of regional security agreements

    SciTech Connect

    Pregenzer, A.L.; Vannoni, M.; Biringer, K.L.

    1995-08-01

    This paper argues that cooperative monitoring plays a critical role in the implementation of regional security agreements and confidence building measures. A framework for developing cooperative monitoring options is proposed and several possibilities for relating bilateral and regional monitoring systems to international monitoring systems are discussed. Three bilateral or regional agreements are analyzed briefly to illustrate different possibilities: (1) the demilitarization of the Sinai region between Israel and Egypt in the 1970s; (2) the 1991 quadripartite agreement for monitoring nuclear facilities among Brazil, Argentina, The Argentine-Brazilian Agency for Accounting and Control of Nuclear Materials and the International Atomic Energy Agency; and (3) a bilateral Open Skies agreement between Hungary and Romania in 1991. These examples illustrate that the relationship of regional or bilateral arms control or security agreements to international agreements depends on a number of factors: the overlap of provisions between regional and international agreements; the degree of interest in a regional agreement among the international community; efficiency in implementing the agreement; and numerous political considerations.Given the importance of regional security to the international community, regions should be encouraged to develop their own infrastructure for implementing regional arms control and other security agreements. A regional infrastructure need not preclude participation in an international regime. On the contrary, establishing regional institutions for arms control and nonproliferation could result in more proactive participation of regional parties in developing solutions for regional and international problems, thereby strengthening existing and future international regimes. Possible first steps for strengthening regional infrastructures are identified and potential technical requirements are discussed.

  13. International Agreement on Planetary Protection

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The maintenance of a NASA policy, is consistent with international agreements. The planetary protection policy management in OSS, with Field Center support. The advice from internal and external advisory groups (NRC, NAC/Planetary Protection Task Force). The technology research and standards development in bioload characterization. The technology research and development in bioload reduction/sterilization. This presentation focuses on: forward contamination - research on the potential for Earth life to exist on other bodies, improved strategies for planetary navigation and collision avoidance, and improved procedures for sterile spacecraft assembly, cleaning and/or sterilization; and backward contamination - development of sample transfer and container sealing technologies for Earth return, improvement in sample return landing target assessment and navigation strategy, planning for sample hazard determination requirements and procedures, safety certification, (liaison to NEO Program Office for compositional data on small bodies), facility planning for sample recovery system, quarantine, and long-term curation of 4 returned samples.

  14. 24 CFR 200.50 - Building loan agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building loan agreement. 200.50 Section 200.50 Housing and Urban Development Regulations Relating to Housing and Urban Development... Building loan agreement. The mortgagor and mortgagee must execute a building loan agreement approved by...

  15. 24 CFR 200.50 - Building loan agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Building loan agreement. 200.50 Section 200.50 Housing and Urban Development Regulations Relating to Housing and Urban Development... Building loan agreement. The mortgagor and mortgagee must execute a building loan agreement approved by...

  16. 24 CFR 200.50 - Building loan agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Building loan agreement. 200.50 Section 200.50 Housing and Urban Development Regulations Relating to Housing and Urban Development... Building loan agreement. The mortgagor and mortgagee must execute a building loan agreement approved by...

  17. 24 CFR 200.50 - Building loan agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Building loan agreement. 200.50 Section 200.50 Housing and Urban Development Regulations Relating to Housing and Urban Development... Building loan agreement. The mortgagor and mortgagee must execute a building loan agreement approved by...

  18. 24 CFR 200.50 - Building loan agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Building loan agreement. 200.50 Section 200.50 Housing and Urban Development Regulations Relating to Housing and Urban Development... Building loan agreement. The mortgagor and mortgagee must execute a building loan agreement approved by...

  19. 24 CFR 700.140 - Participatory agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Participatory agreement. 700.140 Section 700.140 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF THE SECRETARY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HOUSING ASSISTANCE...

  20. 24 CFR 241.635 - Regulatory agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Regulatory agreement. 241.635 Section 241.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  1. 24 CFR 241.635 - Regulatory agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Regulatory agreement. 241.635 Section 241.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  2. 24 CFR 582.400 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Grant agreement. 582.400 Section 582.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  3. 24 CFR 585.402 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Grant agreement. 585.402 Section 585.402 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  4. 24 CFR 582.400 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Grant agreement. 582.400 Section 582.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  5. 24 CFR 582.400 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Grant agreement. 582.400 Section 582.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  6. 24 CFR 280.30 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Grant agreement. 280.30 Section 280.30 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT GRANT PROGRAMS NEHEMIAH HOUSING OPPORTUNITY GRANTS PROGRAM Program Operation § 280.30...

  7. 24 CFR 280.30 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Grant agreement. 280.30 Section 280.30 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT GRANT PROGRAMS NEHEMIAH HOUSING OPPORTUNITY GRANTS PROGRAM Program Operation § 280.30...

  8. 24 CFR 964.215 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Grant agreement. 964.215 Section 964.215 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT TENANT PARTICIPATION AND...

  9. 24 CFR 585.402 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Grant agreement. 585.402 Section 585.402 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  10. 24 CFR 280.30 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Grant agreement. 280.30 Section 280.30 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT GRANT PROGRAMS NEHEMIAH HOUSING OPPORTUNITY GRANTS PROGRAM Program Operation § 280.30...

  11. 24 CFR 582.400 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Grant agreement. 582.400 Section 582.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  12. 24 CFR 585.402 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Grant agreement. 585.402 Section 585.402 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  13. 24 CFR 585.402 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Grant agreement. 585.402 Section 585.402 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  14. 24 CFR 280.30 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Grant agreement. 280.30 Section 280.30 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT GRANT PROGRAMS NEHEMIAH HOUSING OPPORTUNITY GRANTS PROGRAM Program Operation § 280.30...

  15. 24 CFR 964.335 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Grant agreement. 964.335 Section 964.335 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT TENANT PARTICIPATION AND...

  16. 24 CFR 280.30 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Grant agreement. 280.30 Section 280.30 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT GRANT PROGRAMS NEHEMIAH HOUSING OPPORTUNITY GRANTS PROGRAM Program Operation § 280.30...

  17. 24 CFR 241.635 - Regulatory agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Regulatory agreement. 241.635 Section 241.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  18. 24 CFR 241.635 - Regulatory agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Regulatory agreement. 241.635 Section 241.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  19. 24 CFR 241.635 - Regulatory agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Regulatory agreement. 241.635 Section 241.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  20. New species of Scalibregmatidae (Annelida, Polychaeta) from the East Antarctic Peninsula including a description of the ecology and post-larval development of species of Scalibregma and Oligobregma.

    PubMed

    Blake, James A

    2015-01-01

    A large collection of scalibregmatid polychaetes from the east Antarctic Peninsula in May 2000 has yielded specimens of three new species of Scalibregma, Pseudoscalibregma, and Oligobregma. The new species of Scalibregma is represented by more than 400 specimens that include post-larval and juvenile forms which, for the first time, provide data on the sequence of development of key characters of a scalibregmatid. These data demonstrate that taxonomic characters including the form of the prostomium and presence of branchiae develop late in ontogeny and that small specimens cannot be reliably referred to a species or genus without a growth sequence. Juvenile morphology is also presented for the new species of Oligobregma. The new species of Scalibregma is compared with five northern hemisphere species and differs in details of the peristomium, upper and lower lips of the mouth, dorsal and ventral cirri, and nature of the short spinous setae of setiger 1. The new species of Pseudoscalibregma is unique in the nature of asymmetrical ventral cirri of posterior setigers. The new species of Oligobregma has large acicular spines in both noto- and neuropodia and these are present in juveniles. However, the final adult configuration of the prostomium is not evident until late in development. The taxonomic significance of the timing of development of post-larval and juvenile morphology elucidated in this study is discussed in relation to the validity of certain taxa and the current system of genera used in the family. PMID:26624392

  1. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  2. Assessment of pharmacogenomic agreement

    PubMed Central

    Safikhani, Zhaleh; El-Hachem, Nehme; Quevedo, Rene; Smirnov, Petr; Goldenberg, Anna; Juul Birkbak, Nicolai; Mason, Christopher; Hatzis, Christos; Shi, Leming; Aerts, Hugo JWL; Quackenbush, John; Haibe-Kains, Benjamin

    2016-01-01

    In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE), were inconsistent. The GDSC and CCLE investigators recently reported that their respective studies exhibit reasonable agreement and yield similar molecular predictors of drug response, seemingly contradicting our previous findings. Reanalyzing the authors’ published methods and results, we found that their analysis failed to account for variability in the genomic data and more importantly compared different drug sensitivity measures from each study, which substantially deviate from our more stringent consistency assessment. Our comparison of the most updated genomic and pharmacological data from the GDSC and CCLE confirms our published findings that the measures of drug response reported by these two groups are not consistent. We believe that a principled approach to assess the reproducibility of drug sensitivity predictors is necessary before envisioning their translation into clinical settings. PMID:27408686

  3. Assessment of pharmacogenomic agreement.

    PubMed

    Safikhani, Zhaleh; El-Hachem, Nehme; Quevedo, Rene; Smirnov, Petr; Goldenberg, Anna; Juul Birkbak, Nicolai; Mason, Christopher; Hatzis, Christos; Shi, Leming; Aerts, Hugo Jwl; Quackenbush, John; Haibe-Kains, Benjamin

    2016-01-01

    In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE), were inconsistent. The GDSC and CCLE investigators recently reported that their respective studies exhibit reasonable agreement and yield similar molecular predictors of drug response, seemingly contradicting our previous findings. Reanalyzing the authors' published methods and results, we found that their analysis failed to account for variability in the genomic data and more importantly compared different drug sensitivity measures from each study, which substantially deviate from our more stringent consistency assessment. Our comparison of the most updated genomic and pharmacological data from the GDSC and CCLE confirms our published findings that the measures of drug response reported by these two groups are not consistent. We believe that a principled approach to assess the reproducibility of drug sensitivity predictors is necessary before envisioning their translation into clinical settings. PMID:27408686

  4. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

    PubMed Central

    Takahashi, Kazue; Chang, Wei-Chuan; Takahashi, Minoru; Pavlov, Vasile; Ishida, Yumi; La Bonte, Laura; Shi, Lei; Fujita, Teizo; Stahl, Gregory L.; Van Cott, Elizabeth M.

    2010-01-01

    The first line of host defense is the innate immune system that includes coagulation factors and pattern recognition molecules, one of which is mannose-binding lectin (MBL). Previous studies have demonstrated that MBL deficiency increases susceptibility to infection. Several mechanisms are associated with increased susceptibility to infection, including reduced opsonophagocytic killing and reduced lectin complement pathway activation. In this study, we demonstrate that MBL and MBL-associated serine protease (MASP)-1/3 together mediate coagulation factor-like activities, including thrombin-like activity. MBL and/or MASP-1/3 deficient hosts demonstrate in vivo evidence that MBL and MASP-1/3 are involved with hemostasis following injury. Staphylococcus aureus infected MBL null mice developed disseminated intravascular coagulation (DIC), which was associated with elevated blood IL-6 levels (but not TNF-α and multi-organ inflammatory responses). Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest into DIC and organ failure during infectious diseases. PMID:20399528

  5. Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446-Part II: Effects on Prenatal and Postnatal Development, Including Maternal Function in Sprague-Dawley Rats.

    PubMed

    Yimam, Mesfin; Lee, Young-Chul; Hyun, Eu-Jin; Jia, Qi

    2015-08-01

    Almost all herbal remedies could be therapeutic at one dose and toxic at another. These facts become more troubling and a double threat when uncharacterized medicinal herbs are blended together and used by expectant mothers as a supplement to conventional pregnancy management with an inherent belief of considering herbal remedies as harmless. Here we describe the potential adverse effects of UP446, a standardized bioflavonoid composition from the roots of Scutellaria baicalensis and the heartwoods of Acacia catechu, on the maternal and their first filial generation (F1) developmental and functional toxicity following exposure at doses of 250, 500, and 1000 mg/kg/day. Maternal gestation, viability index, sex ratio, body weight, and food consumption were evaluated. F1 growth and development, sexual function including mating index, fertility, implantation, and embryo mortality were also assessed. Test substance impacts on the maternal (F0) or F1 reproductive parameters were very minimal. There were no statistically significant differences in implantation, parturition, viability, and neonates' sex ratios. There were no significant changes in maturation, behavioral, or functional developments between groups. No treatment-related prenatal or postnatal in-life or necropsy abnormalities were observed. Therefore, the no observed adverse effect level in the prenatal and postnatal developments, including maternal function study was considered to be greater than 1000 mg/kg. PMID:26033919

  6. Inverse transonic airfoil design including viscous interaction

    NASA Technical Reports Server (NTRS)

    Carlson, L. A.

    1976-01-01

    A numerical technique was developed for the analysis of specified transonic airfoils or for the design of airfoils having a prescribed pressure distribution, including the effect of weak viscous interaction. The method uses the full potential equation, a stretched Cartesian coordinate system, and the Nash-MacDonald turbulent boundary layer method. Comparisons with experimental data for typical transonic airfoils show excellent agreement. An example shows the application of the method to design a thick aft-cambered airfoil, and the effects of viscous interaction on its performance are discussed.

  7. Agreement with Subjects in Lubukusu

    ERIC Educational Resources Information Center

    Diercks, Michael J. K.

    2010-01-01

    This dissertation examines three topics in the morphosyntax of Lubukusu (Bantu, Kenya), all of which are concerned with agreement with subjects: locative inversion, complementizer agreement, and alternative agreement effects in subject extraction. Each topic reports novel Lubukusu data which are both typologically interesting and theoretically…

  8. 24 CFR 964.215 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Grant agreement. 964.215 Section 964.215 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  9. 24 CFR 964.215 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Grant agreement. 964.215 Section 964.215 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  10. 24 CFR 964.335 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Grant agreement. 964.335 Section 964.335 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  11. 24 CFR 964.335 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Grant agreement. 964.335 Section 964.335 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  12. 24 CFR 964.335 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Grant agreement. 964.335 Section 964.335 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  13. 24 CFR 964.215 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Grant agreement. 964.215 Section 964.215 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN...

  14. Use of an Activated Beta-Catenin to Identify Wnt Pathway Target Genes in Caenorhabditis elegans, Including a Subset of Collagen Genes Expressed in Late Larval Development

    PubMed Central

    Jackson, Belinda M.; Abete-Luzi, Patricia; Krause, Michael W.; Eisenmann, David M.

    2014-01-01

    The Wnt signaling pathway plays a fundamental role during metazoan development, where it regulates diverse processes, including cell fate specification, cell migration, and stem cell renewal. Activation of the beta-catenin−dependent/canonical Wnt pathway up-regulates expression of Wnt target genes to mediate a cellular response. In the nematode Caenorhabditis elegans, a canonical Wnt signaling pathway regulates several processes during larval development; however, few target genes of this pathway have been identified. To address this deficit, we used a novel approach of conditionally activated Wnt signaling during a defined stage of larval life by overexpressing an activated beta-catenin protein, then used microarray analysis to identify genes showing altered expression compared with control animals. We identified 166 differentially expressed genes, of which 104 were up-regulated. A subset of the up-regulated genes was shown to have altered expression in mutants with decreased or increased Wnt signaling; we consider these genes to be bona fide C. elegans Wnt pathway targets. Among these was a group of six genes, including the cuticular collagen genes, bli-1col-38, col-49, and col-71. These genes show a peak of expression in the mid L4 stage during normal development, suggesting a role in adult cuticle formation. Consistent with this finding, reduction of function for several of the genes causes phenotypes suggestive of defects in cuticle function or integrity. Therefore, this work has identified a large number of putative Wnt pathway target genes during larval life, including a small subset of Wnt-regulated collagen genes that may function in synthesis of the adult cuticle. PMID:24569038

  15. Development of eggs and larvae of Emmelichthys nitidus (Percoidei: Emmelichthyidae) in south-eastern Australia, including a temperature-dependent egg incubation model

    NASA Astrophysics Data System (ADS)

    Neira, Francisco J.; Keane, John P.; Lyle, Jeremy M.; Tracey, Sean R.

    2008-08-01

    Reared eggs and field-collected material were employed to describe the development of the pelagic eggs and larvae of Emmelichthys nitidus (Emmelichthyidae), a small (36 cm TL) mid-water schooling species common in shelf waters of temperate Australia. Hydrated oocytes from adults trawled from spawning grounds off eastern Tasmania were fertilized and reared to the yolk-sac larval stage, and the data employed to build a temperature-dependent egg incubation model. Embryogenesis lasted 96, 84 and 54 h at mean temperatures of 13.1, 14.4 and 16.5 °C respectively, and was divided into seven stages based on extent of epiboly until blastopore closure (stages I-III) and embryo growth (stages IV-VII). Eggs (1.00-1.05 mm diameter) are spherical with a smooth chorion, small perivitelline space and prominent, unsegmented yolk with a single, posteriorly-located oil globule (0.18-0.20 mm diameter) that becomes pigmented from stage III. Embryos have two distinct snout melanophores, and a paired melanophore row laterally along the trunk and tail. Morphological identification of eggs collected during surveys in October 2005 and 2006 was validated using quantitative PCR amplification of the mtDNA d-loop gene region unique to E. nitidus, producing an 80-100% agreement across all seven stages. Newly-emerged larvae (1.9-3.3 mm) possess a prominent yolk sac with the posteriorly-located, pigmented oil globule, mouth not yet functional and unpigmented eyes. Notochord flexion occurs between 5 and 8 mm while fins are formed by 12 mm. Larvae examined (3.3-17.4 mm) are lightly pigmented and possess percoid features such as an elongate to moderate body, coiled, triangular-shaped gut, preopercular spines and 24-25 myomeres; two prominent pigment patches opposite each other dorsally and ventrally along the tail are diagnostic. Variability of mean egg ages ( y) by temperature ( t) and stage ( i) was best described by the deterministic stage-to-age model y = 35.911exp[-(0.155 t + 0.262 i)] i2

  16. 24 CFR 3288.110 - Alternative Process agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Alternative Process agreements... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME DISPUTE RESOLUTION PROGRAM Alternative Process in HUD-Administered States § 3288.110 Alternative Process agreements. (a) Required agreement. To use the...

  17. 24 CFR 3288.110 - Alternative Process agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Alternative Process agreements... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME DISPUTE RESOLUTION PROGRAM Alternative Process in HUD-Administered States § 3288.110 Alternative Process agreements. (a) Required agreement. To use the...

  18. Residence Halls Unit Agreements: A Step Beyond Rules and Regulations.

    ERIC Educational Resources Information Center

    Scheuermann, Thomas A.; Grandner, Deborah Francis

    1986-01-01

    Discusses the philosophical basis of the Unit Agreement program, provides a description of the Unit Agreement process and how it was developed, and presents the results of a campuswide study of the program's effect on the residence hall environment. (ABB)

  19. Program management plan for development, demonstration, testing, and evaluation efforts associated with Oak Ridge Reservation`s Land Disposal Restrictions Federal Facility Compliance Agreement

    SciTech Connect

    Conley, T.B.

    1994-04-01

    This program management plan covers the development, demonstration, testing, and evaluation efforts necessary to identify treatment methods for all the waste listed in Appendix B of the ORR`s LDR/FFCA as well as any new wastes which meet Appendix B criteria. To successfully identify a treatment method, at least a proof-of-principle level of understanding must be obtained: that is, the candidate processes must be demonstrated as effective in treating the wastes to the LDR; however, an optimized process is not required. Where applicable and deemed necessary and where the budgets will support them, pilot-scale demonstrations will be pursued. The overall strategy being adopted in this program will be composed of the following activities: Scoping of the study; characterization; development and screening of alternatives; treatability investigations; and detailed analysis of alternatives.

  20. Development and Field-Testing of a Study Protocol, including a Web-Based Occupant Survey Tool, for Use in Intervention Studies of Indoor Environmental Quality

    SciTech Connect

    Mendell, Mark; Eliseeva, Ekaterina; Spears, Michael; Fisk, William J.

    2009-06-01

    We developed and pilot-tested an overall protocol for intervention studies to evaluate the effects of indoor environmental changes in office buildings on the health symptoms and comfort of occupants. The protocol includes a web-based survey to assess the occupant's responses, as well as specific features of study design and analysis. The pilot study, carried out on two similar floors in a single building, compared two types of ventilation system filter media. With support from the building's Facilities staff, the implementation of the filter change intervention went well. While the web-based survey tool worked well also, low overall response rates (21-34percent among the three work groups included) limited our ability to evaluate the filter intervention., The total number of questionnaires returned was low even though we extended the study from eight to ten weeks. Because another simultaneous study we conducted elsewhere using the same survey had a high response rate (>70percent), we conclude that the low response here resulted from issues specific to this pilot, including unexpected restrictions by some employing agencies on communication with occupants.

  1. 22 CFR 124.7 - Information required in all manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... defense articles to be exported, including any test and support equipment or advanced materials. They.... Only defense articles listed in the agreement will be eligible for export under the exemption in §...

  2. Development of new method and protocol for cryopreservation related to embryo and oocytes freezing in terms of fertilization rate: A comparative study including review of literature

    PubMed Central

    Barik, Mayadhar; Bajpai, Minu; Patnaik, Santosh; Mishra, Pravash; Behera, Priyamadhaba; Dwivedi, Sada Nanda

    2016-01-01

    Background: Cryopreservation is basically related to meritorious thin samples or small clumps of cells that are cooled quickly without loss. Our main objective is to establish and formulate an innovative method and protocol development for cryopreservation as a gold standard for clinical uses in laboratory practice and treatment. The knowledge regarding usefulness of cryopreservation in clinical practice is essential to carry forward the clinical practice and research. Materials and Methods: We are trying to compare different methods of cryopreservation (in two dozen of cells) at the same time we compare the embryo and oocyte freezing interms of fertilization rate according to the International standard protocol. Results: The combination of cryoprotectants and regimes of rapid cooling and rinsing during warming often allows successful cryopreservation of biological materials, particularly cell suspensions or thin tissue samples. Examples include semen, blood, tissue samples like tumors, histological cross-sections, human eggs and human embryos. Although presently many studies have reported that the children born from frozen embryos or “frosties,” show consistently positive results with no increase in birth defects or development abnormalities is quite good enough and similar to our study (50–85%). Conclusions: We ensure that cryopreservation technology provided useful cell survivability, tissue and organ preservation in a proper way. Although it varies according to different laboratory conditions, it is certainly beneficial for patient's treatment and research. Further studies are needed for standardization and development of new protocol. PMID:27512686

  3. Concerning the Development of the Wide-Field Optics for WFXT Including Methods of Optimizing X-Ray Optical Prescriptions for Wide-Field Applications

    NASA Technical Reports Server (NTRS)

    Weisskopf, M. C.; Elsner, R. F.; O'Dell, S. L.; Ramsey, B. D.

    2010-01-01

    We present a progress report on the various endeavors we are undertaking at MSFC in support of the Wide Field X-Ray Telescope development. In particular we discuss assembly and alignment techniques, in-situ polishing corrections, and the results of our efforts to optimize mirror prescriptions including polynomial coefficients, relative shell displacements, detector placements and tilts. This optimization does not require a blind search through the multi-dimensional parameter space. Under the assumption that the parameters are small enough so that second order expansions are valid, we show that the performance at the detector can be expressed as a quadratic function with numerical coefficients derived from a ray trace through the underlying Wolter I optic. The optimal values for the parameters are found by solving the linear system of equations creating by setting derivatives of this function with respect to each parameter to zero.

  4. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus.

    PubMed

    Liu, Jie; Ochieng, Caroline; Wiersma, Steve; Ströher, Ute; Towner, Jonathan S; Whitmer, Shannon; Nichol, Stuart T; Moore, Christopher C; Kersh, Gilbert J; Kato, Cecilia; Sexton, Christopher; Petersen, Jeannine; Massung, Robert; Hercik, Christine; Crump, John A; Kibiki, Gibson; Maro, Athanasia; Mujaga, Buliga; Gratz, Jean; Jacob, Shevin T; Banura, Patrick; Scheld, W Michael; Juma, Bonventure; Onyango, Clayton O; Montgomery, Joel M; Houpt, Eric; Fields, Barry

    2016-01-01

    Acute febrile illness (AFI) is associated with substantial morbidity and mortality worldwide, yet an etiologic agent is often not identified. Convalescent-phase serology is impractical, blood culture is slow, and many pathogens are fastidious or impossible to cultivate. We developed a real-time PCR-based TaqMan array card (TAC) that can test six to eight samples within 2.5 h from sample to results and can simultaneously detect 26 AFI-associated organisms, including 15 viruses (chikungunya, Crimean-Congo hemorrhagic fever [CCHF] virus, dengue, Ebola virus, Bundibugyo virus, Sudan virus, hantaviruses [Hantaan and Seoul], hepatitis E, Marburg, Nipah virus, o'nyong-nyong virus, Rift Valley fever virus, West Nile virus, and yellow fever virus), 8 bacteria (Bartonella spp., Brucella spp., Coxiella burnetii, Leptospira spp., Rickettsia spp., Salmonella enterica and Salmonella enterica serovar Typhi, and Yersinia pestis), and 3 protozoa (Leishmania spp., Plasmodium spp., and Trypanosoma brucei). Two extrinsic controls (phocine herpesvirus 1 and bacteriophage MS2) were included to ensure extraction and amplification efficiency. Analytical validation was performed on spiked specimens for linearity, intra-assay precision, interassay precision, limit of detection, and specificity. The performance of the card on clinical specimens was evaluated with 1,050 blood samples by comparison to the individual real-time PCR assays, and the TAC exhibited an overall 88% (278/315; 95% confidence interval [CI], 84% to 92%) sensitivity and a 99% (5,261/5,326, 98% to 99%) specificity. This TaqMan array card can be used in field settings as a rapid screen for outbreak investigation or for the surveillance of pathogens, including Ebola virus. PMID:26491176

  5. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus

    PubMed Central

    Liu, Jie; Ochieng, Caroline; Wiersma, Steve; Ströher, Ute; Towner, Jonathan S.; Whitmer, Shannon; Nichol, Stuart T.; Moore, Christopher C.; Kersh, Gilbert J.; Kato, Cecilia; Sexton, Christopher; Petersen, Jeannine; Massung, Robert; Hercik, Christine; Crump, John A.; Kibiki, Gibson; Maro, Athanasia; Mujaga, Buliga; Gratz, Jean; Jacob, Shevin T.; Banura, Patrick; Scheld, W. Michael; Juma, Bonventure; Onyango, Clayton O.; Montgomery, Joel M.

    2015-01-01

    Acute febrile illness (AFI) is associated with substantial morbidity and mortality worldwide, yet an etiologic agent is often not identified. Convalescent-phase serology is impractical, blood culture is slow, and many pathogens are fastidious or impossible to cultivate. We developed a real-time PCR-based TaqMan array card (TAC) that can test six to eight samples within 2.5 h from sample to results and can simultaneously detect 26 AFI-associated organisms, including 15 viruses (chikungunya, Crimean-Congo hemorrhagic fever [CCHF] virus, dengue, Ebola virus, Bundibugyo virus, Sudan virus, hantaviruses [Hantaan and Seoul], hepatitis E, Marburg, Nipah virus, o'nyong-nyong virus, Rift Valley fever virus, West Nile virus, and yellow fever virus), 8 bacteria (Bartonella spp., Brucella spp., Coxiella burnetii, Leptospira spp., Rickettsia spp., Salmonella enterica and Salmonella enterica serovar Typhi, and Yersinia pestis), and 3 protozoa (Leishmania spp., Plasmodium spp., and Trypanosoma brucei). Two extrinsic controls (phocine herpesvirus 1 and bacteriophage MS2) were included to ensure extraction and amplification efficiency. Analytical validation was performed on spiked specimens for linearity, intra-assay precision, interassay precision, limit of detection, and specificity. The performance of the card on clinical specimens was evaluated with 1,050 blood samples by comparison to the individual real-time PCR assays, and the TAC exhibited an overall 88% (278/315; 95% confidence interval [CI], 84% to 92%) sensitivity and a 99% (5,261/5,326, 98% to 99%) specificity. This TaqMan array card can be used in field settings as a rapid screen for outbreak investigation or for the surveillance of pathogens, including Ebola virus. PMID:26491176

  6. 75 FR 40837 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ....gov . Agreement No.: 011279-027. Title: Latin America Agreement. Parties: ABC Discussion Agreement; Caribbean Shipowners Association; Central America Discussion Agreement; Compania Libra de Navegacion Uruguay S.A.; Inland Shipping Services Association; Venezuelan Discussion Agreement; West Coast of...

  7. Canadian seismic agreement

    SciTech Connect

    Wetmiller, R.J.; Lyons, J.A.; Shannon, W.E.; Munro, P.S.; Thomas, J.T.; Andrew, M.D.; Lamontagne, M.; Wong, C.; Anglin, F.M.; Plouffe, M.; Adams, J.; Drysdale, J.A. . Geophysics Div.)

    1990-04-01

    During the period of this report, the contract resources were spent on operation and maintenance of the Eastern Canada Telemetred Network (ECTN), development of special purpose local network systems, servicing and maintenance of the strong-motion seismograph network in eastern Canada, operation of the Ottawa data lab and earthquake monitoring and reporting. Of special note in this period was the final completion of the Sudbury (SLTN) and Charlevoix (CLTN) local networks and the integration of their data processing and analysis requirements in the regular analysis stream for ECTN data. These networks now acquire high quality digital data for detailed analysis of seismic activity and source properties from these two areas, thus effectively doubling the amount of seismic data being received by the Ottawa data lab. 37 refs., 17 figs., 2 tabs.

  8. Clock Agreement Among Parallel Supercomputer Nodes

    DOE Data Explorer

    Jones, Terry R.; Koenig, Gregory A.

    2014-04-30

    This dataset presents measurements that quantify the clock synchronization time-agreement characteristics among several high performance computers including the current world's most powerful machine for open science, the U.S. Department of Energy's Titan machine sited at Oak Ridge National Laboratory. These ultra-fast machines derive much of their computational capability from extreme node counts (over 18000 nodes in the case of the Titan machine). Time-agreement is commonly utilized by parallel programming applications and tools, distributed programming application and tools, and system software. Our time-agreement measurements detail the degree of time variance between nodes and how that variance changes over time. The dataset includes empirical measurements and the accompanying spreadsheets.

  9. 34 CFR 303.15 - Include; including.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include; including. 303.15 Section 303.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS...

  10. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite...

  11. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite...

  12. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite...

  13. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite...

  14. 29 CFR 500.72 - Agreements with workers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SEASONAL AGRICULTURAL WORKER PROTECTION Worker Protections General § 500.72 Agreements with workers. (a... seasonal agricultural workers. Normally, “without justification” would not include situations in...

  15. 29 CFR 500.72 - Agreements with workers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SEASONAL AGRICULTURAL WORKER PROTECTION Worker Protections General § 500.72 Agreements with workers. (a... seasonal agricultural workers. Normally, “without justification” would not include situations in...

  16. Mutation Analysis of NR5A1 Encoding Steroidogenic Factor 1 in 77 Patients with 46, XY Disorders of Sex Development (DSD) Including Hypospadias

    PubMed Central

    Brauner, Raja; Lourenço, Diana; Boudjenah, Radia; Karageorgou, Vasiliki; Trivin, Christine; Lottmann, Henri; Lortat-Jacob, Stephen; Nihoul-Fékété, Claire; De Dreuzy, Olivier; McElreavey, Ken; Bashamboo, Anu

    2011-01-01

    Background Mutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias. Methodology/Principal Findings We evaluated the frequency of NR5A1 gene mutations in a large series of patients presenting with 46,XY DSD and hypospadias. Based on their clinical presentation 77 patients were classified either as complete or partial gonadal dysgenesis (uterus seen at genitography and/or surgery, n = 11), ambiguous external genitalia without uterus (n = 33) or hypospadias (n = 33). We identified heterozygous NR5A1 mutations in 4 cases of ambiguous external genitalia without uterus (12.1%; p.Trp279Arg, pArg39Pro, c.390delG, c140_141insCACG) and a de novo missense mutation in one case with distal hypospadias (3%; p.Arg313Cys). Mutant proteins showed reduced transactivation activity and mutants p.Arg39Pro and p.Arg313Cys did not synergize with the GATA4 cofactor to stimulate reporter gene activity, although they retained their ability to physically interact with the GATA4 protein. Conclusions/Significance Mutations in NR5A1 were observed in 5/77 (6.5%) cases of 46,XY DSD including hypospadias. Excluding the cases of 46,XY gonadal dysgenesis the incidence of NR5A1 mutations was 5/66 (7.6%). An individual with isolated distal hypopadias carried a de novo heterozygous missense mutation, thus extending the range of phenotypes associated with NR5A1 mutations and suggesting that this group of patients should be screened for NR5A1 mutations. PMID:22028768

  17. Skills agreement. Recipe for success.

    PubMed

    Nolan, Alexis

    2007-06-21

    The aims of the national health Sector Skills Agreement need regional and local implementation by stakeholders to become reality. Work in the East of England will produce a first regional skills agreement later this year. The Harlow Project is producing award winning process on recuitment and retention. PMID:17847967

  18. Interspecies difference in placement of developing teeth and its relationship with cross-sectional geometry of the mandibular symphysis in four primate species including modern humans.

    PubMed

    Fukase, Hitoshi

    2012-02-01

    The form of the anthropoid mandibular symphysis has recently been addressed in association with spatial requirements for the forming anterior teeth. To evaluate potential relationships between the symphyseal shape and teeth further, the growth patterns of the symphyseal region and the positioning of the tooth crypts were examined using CT data, comparing four primate species (modern humans, chimpanzees, Japanese monkeys, and hamadryas baboons) with varied symphyseal curvature and tooth size. First, results showed that interspecies differences in overall mandibular shape including symphyseal inclination and bicanine width are consistently expressed throughout postnatal ontogeny, although local symphyseal configurations related to the superior transverse torus (STT) tended to change considerably during growth in chimpanzees. Second, the four species were found to exhibit differentiated formation positions of the incisor and canine crypts. In particular, I2 developed between I1 and C in humans with a broad bicanine space and small teeth, whereas it was positioned posterior to I1 and above C in the cercopithecines with an extremely narrow bicanine space. In chimpanzees, despite the large bicanine width, I1 and I2 grew with a large antero-posterior overlap owing to their large size. These results indicate that the dental positioning is determined in concert with the size balance of the available mandibular space and forming teeth. Finally, the positions/contours of I2 crypt were shown to correspond strongly with the STT across the taxa. This suggests that interspecies differences in symphyseal shape should be interpreted partially by the species-specific positional relationships of the developing anterior teeth. PMID:22120684

  19. A reevaluation of the lineage development of Pararotalia and Praepararotalia including new material from the Rupelian of the southern Upper Rhine Graben

    NASA Astrophysics Data System (ADS)

    Pirkenseer, C.; Spezzaferri, S.

    2009-04-01

    more rapid increase of chamber size. The necessity of a new genus is in discussion. The second group includes the small intermediate species as Pararotalia ishamae, characterized by inflated globular chambers, a general absence of a keel, partial development of small pseudospines and umbilical plugs. This group can be traced up to recent, as is indicated by the occurrence of small sized Pararotalia cananeiaensis (DEBENAY et al. 2001). Material from the research area (PIRKENSEER 2007), though of generally larger size is attributed to the Rupelian P. curryi. It however shows variation in the development of pseudospines, the lateral profile and umbilicus. The latter species may be a synonym of the similar Late Eocene P. parva. The third group consists only of Pararotalia spinigera (Lutetian) and Pararotalia canui (Rupelian) with an inflated angular lateral profile and a relatively large size. Material from the research area attributed to P. canui shows massive well-developed peripheral pseudospines, a strong umbilical plug and a rounded keel. Double pseudospines occur sporadically. The apertural lip is heavily toothed. The fourth group consists of species with a very angular lateral profile, conical chambers, distinct umbilical plug and a moderate to very large size (up to 600µm), ranging from the Thanetian (Pararotalia minimalis) at least to the Pliocene (P. padana, MANCIN et al. 2000). This reevaluation indicates the perseverance of the "primitive" group of Pararotalia macneilli until today. It thus contradicts a gradual development of the genus Pararotalia to more spineous, angular and larger forms. The latter morphogroup exists well defined since the Paleocene with representatives throughout the Paleogene and Neogene. This study was partly funded by the Swiss National Science Foundation projects 109457 and 118025. References: DEBENAY, J. P., DULEBA, W., BONETTI, C., et al. (2001): Pararotalia cananeiaensis n. sp.: indicator of marine influence and water circulation

  20. 5 CFR 1655.12 - Loan agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information as appropriate, to the participant. (2) If the participant initiates a loan request on the TSP Web site, which cannot be completed on the Web site, the participant must print the partially completed loan agreement directly from the Web site, provide any missing information (including...

  1. 5 CFR 1655.12 - Loan agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information as appropriate, to the participant. (2) If the participant initiates a loan request on the TSP Web site, which cannot be completed on the Web site, the participant must print the partially completed loan agreement directly from the Web site, provide any missing information (including...

  2. 5 CFR 1655.12 - Loan agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information as appropriate, to the participant. (2) If the participant initiates a loan request on the TSP Web site, which cannot be completed on the Web site, the participant must print the partially completed loan agreement directly from the Web site, provide any missing information (including...

  3. 75 FR 70005 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... operations, including RFID technology; obtain and administer government grants to fund technology-related activities; meet with stakeholders to discuss deployment of RFID technologies; and to establish and manage an entity to implement and administer agreements reached regarding RFID and/or other similar...

  4. 78 FR 21364 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... Working Agreement Asia to USEC and PNW-Suez/PNW & Panama Loops. Parties: A.P. Moller-Maersk A/S and CMA..., South Asia, Middle East (including the Persian Gulf region), Spain, Italy, Egypt, Panama, Jamaica, and Canada, on the one hand, and U.S. East Coast ports via the Panama and Suez canals, on the other hand,...

  5. Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serum.

    PubMed

    Wyns, Ciska; Bolca, Selin; De Keukeleire, Denis; Heyerick, Arne

    2010-04-15

    The investigation into the potential usefulness of phytoestrogens in the treatment of menopausal symptoms requires large-scale clinical trials that involve rapid, validated assays for the characterization and quantification of the phytoestrogenic precursors and their metabolites in biological matrices, as large interindividual differences in metabolism and bioavailability have been reported. Consequently, a new sensitive high-performance liquid chromatography-mass spectrometry method (HPLC-MS) for the quantitative determination of thirteen phytoestrogens including their most important gut microbial metabolites (genistein, daidzein, equol, dihydrodaidzein, O-desmethylangolensin, coumestrol, secoisolariciresinol, matairesinol, enterodiol, enterolactone, isoxanthohumol, xanthohumol and 8-prenylnaringenin) in human urine and serum within one single analytical run was developed. The method uses a simple sample preparation procedure consisting of enzymatic deconjugation followed by liquid-liquid extraction (LLE) or solid-phase extraction (SPE) for urine or serum, respectively. The phytoestrogens and their metabolites are detected with a single quadrupole mass spectrometer using atmospheric pressure chemical ionization (APCI), operating both in the positive and the negative mode. This bioanalytical method has been fully validated and proved to allow an accurate and precise quantification of the targeted phytoestrogens and their metabolites covering the lower parts-per-billion range for the measurement of relevant urine and serum levels following ingestion of phytoestrogen-rich dietary supplements. PMID:20299290

  6. Monitoring of Biomedical License Agreements

    PubMed Central

    Keller, George H.; Ferguson, Steven M.; Pan, Percy

    2009-01-01

    Because technology licensed from research organizations can play a significant role in drug innovation and the generation of novel biomedical products, licensee performance under such agreements must be effectively monitored. This is necessary so that resultant benefits, including public health improvement, may be returned to the innovator(s) as well as society at large. The tasks that comprise monitoring are varied, but all come under the general heading of ‘enforcement of license provisions’. Since 1996, the license monitoring and enforcement program established by the US National Institutes of Health (NIH) Group has collected about $US17 million in unpaid and underpaid license royalties through formal financial audits and other investigative activities. During the same period, the Office of Technology Transfer (OTT) settled more than 60 cases of suspected patent infringement, generating around 60 new licenses and collected both back and ongoing royalties. As these numbers show, an active and effective monitoring program is an essential part of any technology transfer or biomedical licensing program. PMID:19960074

  7. Suspension agreements: The status quota

    SciTech Connect

    1996-01-01

    Since the initial filing of anti-dumping actions uranium imports from the former Soviet Union, a maze of filings, agreements, amendments, bills, measures, and deals have emerged on which only the closest observers remain current. Even with all the actions that have taken place, none of the parties appear content with the status quo and changes to the agreements are ongoing. Given this dynamic state of affairs, a recap of events and a summary of the current agreements is helpful for understanding the concerns of the involved parties and digesting future events.

  8. OPEC agreement and its implications

    SciTech Connect

    Not Available

    1983-01-01

    Following lengthy and intensive negotiations, OPEC recently reached agreement on new prices and production quotas. Although the agreement has been met by general skepticism, Bankers Trust believes that the chances of defending the new marker price are reasonably good. Saudi willingness to reduce oil production and earnings to shield less financially secure OPEC members from the full impact of production cuts provides added and much-needed strength to the organization. If indeed the OPEC agreement proves successful, product prices in the important US market may have already bottomed out.

  9. 76 FR 30360 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ....gov . Agreement No.: 011707-007. Title: Gulf/South America Discussion Agreement. Parties: BBC... Cooperative Working Agreement. Parties: COSCO Terminals America, Inc.; SSA Containers, Inc., and SSA...

  10. WVU cooperative agreement, decontamination systems information and research program, deployment support leading to implementation

    SciTech Connect

    Cook, E.E.

    1996-12-31

    This program at West Virginia University is a Cooperative Agreement that focuses on R&D associated with hazardous waste remediation problems existing at DOE, Corps of Engineers, and private sector sites. The Agreement builds on a unique combination of resources coupling university researchers with DOE sponsored small businesses, leading toward field tests and large scale technology demonstrations of environmental technologies. Most of the Agreement`s projects are categorized in the Technology Maturity Levels under Gates 3-Advanced Development, Gate 4-Engineering Development, and Gate 5-Demonstration. The program includes a diversity of projects: subsurface contaminants; mixed wastes; mixed wastes/efficient separations; mixed wastes/characterization, monitoring, and sensor technologies; and decontamination and decommissioning/efficient separations.

  11. 24 CFR 200.1525 - Settlement agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... negotiate a settlement agreement with a MAP lender before or after the issuance of a warning letter or referral to the MAP Lender Review Board. Once a matter has been referred to the MAP Lender Review...

  12. Systematic Agreement: A Theory of Organizational Alignment.

    ERIC Educational Resources Information Center

    Semler, Steven W.

    1997-01-01

    The theory of organizational alignment considers the extent to which organizational strategy, structure, and culture create an environment that facilitates achievement of organizational objectives and development of high performance work organizations. Well-aligned organizations have systematic agreement among goals, tactics, reward systems, and…

  13. 24 CFR 200.1525 - Settlement agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... negotiate a settlement agreement with a MAP lender before or after the issuance of a warning letter or referral to the MAP Lender Review Board. Once a matter has been referred to the MAP Lender Review...

  14. 24 CFR 200.1525 - Settlement agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... negotiate a settlement agreement with a MAP lender before or after the issuance of a warning letter or referral to the MAP Lender Review Board. Once a matter has been referred to the MAP Lender Review...

  15. 24 CFR 200.1525 - Settlement agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... negotiate a settlement agreement with a MAP lender before or after the issuance of a warning letter or referral to the MAP Lender Review Board. Once a matter has been referred to the MAP Lender Review...

  16. 24 CFR 200.1525 - Settlement agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... negotiate a settlement agreement with a MAP lender before or after the issuance of a warning letter or referral to the MAP Lender Review Board. Once a matter has been referred to the MAP Lender Review...

  17. Carbon-dioxide storage in the subsurface: towards an understanding of crack development in the cap-rock including phase transition processes

    NASA Astrophysics Data System (ADS)

    Häberle, K.; Ehlers, W.

    2012-04-01

    Supercritical CO2 can be injected into deep saline aquifers to reduce the amount of CO2 in the atmosphere and thus, lessen the impact on the global warming. Qualified reservoirs should be in a sufficient depth to guarantee the thermodynamical environment for the supercritical state of CO2. Furthermore, an impermeable cap-rock layer must confine the reservoir layer, in order to collect the CO2 in the desired region. In CO2 storage it is crucial to guarantee the safety of the storage site and to eliminate possibilities of leakage. Therefore, deformation processes of the rock matrix and the cap-rock layer, which might be induced by the high pressure injection of CO2, must be investigated. The increase in stress may also cause crack development in the cap-rock layer. These could either be new developing fractures or the break-up of already existing but cemented cracks or faults. If such cracks occur, CO2 could migrate to shallower regions where the temperature and pressure cannot support the supercritical condition of the CO2 anymore. Thus, it is important to describe the phase transition process between supercritical, liquid and gaseous CO2. This requires a proper understanding of the thermodynamical behaviour of CO2 within the reservoir. The Theory of Porous Media (TPM) provides a useful continuum-mechanical basis to describe real natural systems in a thermodynamically consistent way. Hence, the TPM is applied to model multiphasic flow of CO2 and water and include elasto-plastic solid deformations of the porous matrix. The Peng-Robinson equation is implemented as a cubic equation of state to describe the phase behaviour of CO2 in the liquid, gaseous and supercritical region. However, in the two-phase region the isotherms show a horizontal section and kinks at the boiling and vapour curve. This cannot be represented by a continuously differentiable function such as the Peng-Robinson equation. To circumvent this problem, the Antoine equation provides additional

  18. International Space Station ECLSS Technical Task Agreement Summary Report

    NASA Technical Reports Server (NTRS)

    Ray, C. D. (Compiler); Salyer, B. H. (Compiler)

    1999-01-01

    This Technical Memorandum provides a summary of current work accomplished under Technical Task Agreement (TTA) by the Marshall Space Flight Center (MSFC) regarding the International Space Station (ISS) Environmental Control and Life Support System (ECLSS). Current activities include ECLSS component design and development, computer model development, subsystem/integrated system testing, life testing, and general test support provided to the ISS program. Under ECLSS design, MSFC was responsible for the six major ECLSS functions, specifications and standard, component design and development, and was the architectural control agent for the ISS ECLSS. MSFC was responsible for ECLSS analytical model development. In-house subsystem and system level analysis and testing were conducted in support of the design process, including testing air revitalization, water reclamation and management hardware, and certain nonregenerative systems. The activities described herein were approved in task agreements between MSFC and NASA Headquarters Space Station Program Management Office and their prime contractor for the ISS, Boeing. These MSFC activities are in line to the designing, development, testing, and flight of ECLSS equipment planned by Boeing. MSFC's unique capabilities for performing integrated systems testing and analyses, and its ability to perform some tasks cheaper and faster to support ISS program needs, are the basis for the TTA activities.

  19. Legal Agreements and the Governance of Research Commons: Lessons from Materials Sharing in Mouse Genomics

    PubMed Central

    Mishra, Amrita

    2014-01-01

    Abstract Omics research infrastructure such as databases and bio-repositories requires effective governance to support pre-competitive research. Governance includes the use of legal agreements, such as Material Transfer Agreements (MTAs). We analyze the use of such agreements in the mouse research commons, including by two large-scale resource development projects: the International Knockout Mouse Consortium (IKMC) and International Mouse Phenotyping Consortium (IMPC). We combine an analysis of legal agreements and semi-structured interviews with 87 members of the mouse model research community to examine legal agreements in four contexts: (1) between researchers; (2) deposit into repositories; (3) distribution by repositories; and (4) exchanges between repositories, especially those that are consortium members of the IKMC and IMPC. We conclude that legal agreements for the deposit and distribution of research reagents should be kept as simple and standard as possible, especially when minimal enforcement capacity and resources exist. Simple and standardized legal agreements reduce transactional bottlenecks and facilitate the creation of a vibrant and sustainable research commons, supported by repositories and databases. PMID:24552652

  20. Good Agreements Make Good Friends

    PubMed Central

    Han, The Anh; Pereira, Luís Moniz; Santos, Francisco C.; Lenaerts, Tom

    2013-01-01

    When starting a new collaborative endeavor, it pays to establish upfront how strongly your partner commits to the common goal and what compensation can be expected in case the collaboration is violated. Diverse examples in biological and social contexts have demonstrated the pervasiveness of making prior agreements on posterior compensations, suggesting that this behavior could have been shaped by natural selection. Here, we analyze the evolutionary relevance of such a commitment strategy and relate it to the costly punishment strategy, where no prior agreements are made. We show that when the cost of arranging a commitment deal lies within certain limits, substantial levels of cooperation can be achieved. Moreover, these levels are higher than that achieved by simple costly punishment, especially when one insists on sharing the arrangement cost. Not only do we show that good agreements make good friends, agreements based on shared costs result in even better outcomes. PMID:24045873

  1. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  2. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  3. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  4. 76 FR 31962 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ....gov . Agreement No.: 012128. Title: Southern Africa Agreement A Cooperative Working Agreement. Parties... Atlantic Coast of the United States and ports in the Bahamas and the Republic of South Africa. Agreement...

  5. 77 FR 33459 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... to be exchanged, and delete obsolete language from the agreement. Agreement No.: 012128-001. Title... Agreement and to share the cost of same. Agreement No.: 012173. Title: Hyundai/MOL/APL Asia/Latin...

  6. Effects of Making Sense of SCIENCE[TM] Professional Development on the Achievement of Middle School Students, Including English Language Learners. Final Report. NCEE 2012-4002

    ERIC Educational Resources Information Center

    Heller, Joan I.

    2012-01-01

    This study evaluated an approach to professional development for middle school science teachers by closely examining one grade 8 course that embodies that approach. Using a cluster-randomized experimental design, the study tested the effectiveness of the Making Sense of SCIENCE[TM] professional development course on force and motion (Daehler,…

  7. Gender agreement and multiple referents

    PubMed Central

    Finocchiaro, Chiara; Mahon, Bradford Z.; Caramazza, Alfonso

    2010-01-01

    We report a new pattern of usage in current, spoken Italian that has implications for both psycholinguistic models of language production and linguistic theories of language change. In Italian, gender agreement is mandatory for both singular and plural nouns. However, when two or more nouns of different grammatical gender appear in a conjoined noun phrase (NP), masculine plural agreement is required. In this study, we combined on-line and off-line methodologies in order to assess the mechanisms involved in gender marking in the context of multiple referents. The results of two pronoun production tasks showed that plural feminine agreement was significantly more difficult than plural masculine agreement. In a separate study using offline judgements of acceptability, we found that agreement violations in Italian are tolerated more readily in the case of feminine conjoined noun phrases (e.g., la mela e la banana ‘the:fem apple:fem and the: fem banana: fem’) than masculine conjoined noun phrases (e.g., il fiore e il libro ‘the:mas flower: mas and the:mas book:mas’). Implications of these results are discussed both at the level of functional architecture within the language production system and at the level of changes in language use.* PMID:21037930

  8. Experience and Grammatical Agreement: Statistical Learning Shapes Number Agreement Production

    ERIC Educational Resources Information Center

    Haskell, Todd R.; Thornton, Robert; MacDonald, Maryellen C.

    2010-01-01

    A robust result in research on the production of grammatical agreement is that speakers are more likely to produce an erroneous verb with phrases such as "the key to the cabinets", with a singular noun followed by a plural one, than with phrases such as "the keys to the cabinet", where a plural noun is followed by a singular. These asymmetries are…

  9. Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth

    ERIC Educational Resources Information Center

    Curtin, Carol; Bandini, Linda G.; Must, Aviva; Phillips, Sarah; Maslin, Melissa C. T.; Lo, Charmaine; Gleason, James M.; Fleming, Richard K.; Stanish, Heidi I.

    2016-01-01

    Background: The input of youth with intellectual disabilities in health promotion and health disparities research is essential for understanding their needs and preferences. Regular physical activity (PA) is vital for health and well-being, but levels are low in youth generally, including those with intellectual disabilities. Understanding the…

  10. 22 CFR 211.3 - Cooperating sponsor agreements; program procedure.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Cooperating sponsor agreements; program procedure. 211.3 Section 211.3 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.3 Cooperating sponsor agreements; program procedure. (a)...

  11. 22 CFR 211.3 - Cooperating sponsor agreements; program procedure.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Cooperating sponsor agreements; program procedure. 211.3 Section 211.3 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.3 Cooperating sponsor agreements; program procedure. (a)...

  12. 22 CFR 211.3 - Cooperating sponsor agreements; program procedure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Cooperating sponsor agreements; program procedure. 211.3 Section 211.3 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.3 Cooperating sponsor agreements; program procedure. (a)...

  13. 48 CFR 35.017-1 - Sponsoring agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.017-1 Sponsoring agreements. (a) In order... mission, and ensure a periodic reevaluation of the FFRDC, a written agreement of sponsorship between the... earnings (reserves) and the development of a plan for their use and disposition. (4) A prohibition...

  14. REVIEW OF THE NEGOTIATION OF THE MODEL PROTOCOL ADDITIONAL TO THE AGREEMENT(S) BETWEEN STATE(S) AND THE INTERNATIONAL ATOMIC ENERGY AGENCY FOR THE APPLICATION OF SAFEGUARDS, INFCIRC/540 (Corrected) VOLUME III/III, IAEA COMMITTEE 24, DEVELOPMENT OF INFCIRC/540, ARTICLE-BY-ARTICLE REVIEW (1996-1997).

    SciTech Connect

    Rosenthal, M.D.; Houck, F.

    2010-01-01

    In this section of the report, the development of INFCIRC/540 is traced by a compilation of citations from the IAEA documents presented to the Board of Governors and the records of discussions in the Board that took place prior to the establishment of Committee 24 as well as the documents and discussions of that committee. The evolution of the text is presented separately for each article or, for the more complex articles, for each paragraph or group of paragraphs of the article. This section covers all articles, including those involving no issues. Background, issues, interpretations and conclusions, which were addressed in Volumes I, II, and III are not repeated here. The comments by states that are included are generally limited to objections and suggested changes. Requests for clarification or elaboration have been omitted, although it is recognized that such comments were sometimes veiled objections.

  15. Transuranic Waste Program Framework Agreement - December Deliverable July 2012

    SciTech Connect

    Jones, Patricia

    2012-07-19

    Framework agreement deliverables are: (1) 'DOE/NNSA commits to complete removal of all non-cemented above-ground EM Legacy TRU and newly generated TRU currently-stored at Area G as of October 1, 2011, by no later than June 30, 2014. This inventory of above-ground TRU is defined as 3706 cubic meters of material.' (2) 'DOE commits to the complete removal of all newly generated TRU received in Area G during FY 2012 and 2013 by no later than December 31, 2014.' (3) 'Based on projected funding profiles, DOE/NNSA will develop by December 31, 2012, a schedule, including pacing milestones, for disposition of the below-ground TRU requiring retrieval at Area G.' Objectives are to: (1) restore the 'Core Team' to develop the December, 2012 deliverable; (2) obtain agreement on the strategy for below ground water disposition; and (3) establish timeline for completion of the deliverable. Below Grade Waste Strategy is to: (1) Perform an evaluation on below grade waste currently considered retrievable TRU; (2) Only commit to retrieve waste that must be retrieved; (3) Develop the Deliverable including Pacing Milestones based on planned commitments; (4) Align all Regulatory Documents for Consistency; and (5) answer these 3 primary questions, is the waste TRU; is the waste retrievable, can retrieval cause more harm than benefit?

  16. Mapping Numerical Processing, Reading, and Executive Functions in the Developing Brain: An fMRI Meta-Analysis of 52 Studies Including 842 Children

    ERIC Educational Resources Information Center

    Houde, Olivier; Rossi, Sandrine; Lubin, Amelie; Joliot, Marc

    2010-01-01

    Tracing the connections from brain functions to children's cognitive development and education is a major goal of modern neuroscience. We performed the first meta-analysis of functional magnetic resonance imaging (fMRI) data obtained over the past decade (1999-2008) on more than 800 children and adolescents in three core systems of cognitive…

  17. MRMC analysis of agreement studies

    NASA Astrophysics Data System (ADS)

    Gallas, Brandon D.; Anam, Amrita; Chen, Weijie; Wunderlich, Adam; Zhang, Zhiwei

    2016-03-01

    The purpose of this work is to present and evaluate methods based on U-statistics to compare intra- or inter-reader agreement across different imaging modalities. We apply these methods to multi-reader multi-case (MRMC) studies. We measure reader-averaged agreement and estimate its variance accounting for the variability from readers and cases (an MRMC analysis). In our application, pathologists (readers) evaluate patient tissue mounted on glass slides (cases) in two ways. They evaluate the slides on a microscope (reference modality) and they evaluate digital scans of the slides on a computer display (new modality). In the current work, we consider concordance as the agreement measure, but many of the concepts outlined here apply to other agreement measures. Concordance is the probability that two readers rank two cases in the same order. Concordance can be estimated with a U-statistic and thus it has some nice properties: it is unbiased, asymptotically normal, and its variance is given by an explicit formula. Another property of a U-statistic is that it is symmetric in its inputs; it doesn't matter which reader is listed first or which case is listed first, the result is the same. Using this property and a few tricks while building the U-statistic kernel for concordance, we get a mathematically tractable problem and efficient software. Simulations show that our variance and covariance estimates are unbiased.

  18. Articulation Agreements Ease the Way.

    ERIC Educational Resources Information Center

    Reese, Susan

    2002-01-01

    Articulation agreements between secondary and postsecondary institutions often provide for granting college credit for course work completed at another institution. They have been described as programs designed to create pathways of learning that ease the transition of students from secondary to postsecondary levels. (JOW)

  19. Block Transfer Agreement Evaluation Project

    ERIC Educational Resources Information Center

    Bastedo, Helena

    2010-01-01

    The objective of this project is to evaluate for the British Columbia Council on Admissions and Transfer (BCCAT) the effectiveness of block transfer agreements (BTAs) in the BC Transfer System and recommend steps to be taken to improve their effectiveness. Findings of this study revealed that institutions want to expand block credit transfer;…

  20. Making an Exercise Buddy Agreement

    MedlinePlus

    ... meet your needs. Print out two copies and fill them out together. Then, to make it “official,” both of you should sign them and keep a copy. Review Your Progress Refer back to your agreement at a set time to ...

  1. Water quality studied in areas of unconventional oil and gas development, including areas where hydraulic fracturing techniques are used, in the United States

    USGS Publications Warehouse

    Susong, David D.; Gallegos, Tanya J.; Oelsner, Gretchen P.

    2012-01-01

    The U.S. Geological Survey (USGS) John Wesley Powell Center for Analysis and Synthesis is hosting an interdisciplinary working group of USGS scientists to conduct a temporal and spatial analysis of surface-water and groundwater quality in areas of unconventional oil and gas development. The analysis uses existing national and regional datasets to describe water quality, evaluate water-quality changes over time where there are sufficient data, and evaluate spatial and temporal data gaps.

  2. Planned development and evaluation protocol of two versions of a web-based computer-tailored nutrition education intervention aimed at adults, including cognitive and environmental feedback

    PubMed Central

    2014-01-01

    Background Despite decades of nutrition education, the prevalence of unhealthy dietary patterns is still high and inequalities in intake between high and low socioeconomic groups still exist. Therefore, it is important to innovate and improve existing nutrition education interventions. This paper describes the development, design and evaluation protocol of a web-based computer-tailored nutrition education intervention for adults targeting fruit, vegetable, high-energy snack and fat intake. This intervention innovates existing computer-tailored interventions by not only targeting motivational factors, but also volitional and self-regulation processes and environmental-level factors. Methods/design The intervention development was guided by the Intervention Mapping protocol, ensuring a theory-informed and evidence-based intervention. Two versions of the intervention were developed: a basic version targeting knowledge, awareness, attitude, self-efficacy and volitional and self-regulation processes, and a plus version additionally addressing the home environment arrangement and the availability and price of healthy food products in supermarkets. Both versions consist of four modules: one for each dietary behavior, i.e. fruit, vegetables, high-energy snacks and fat. Based on the self-regulation phases, each module is divided into three sessions. In the first session, feedback on dietary behavior is provided to increase awareness, feedback on attitude and self-efficacy is provided and goals and action plans are stated. In the second session goal achievement is evaluated, reasons for failure are explored, coping plans are stated and goals can be adapted. In the third session, participants can again evaluate their behavioral change and tips for maintenance are provided. Both versions will be evaluated in a three-group randomized controlled trial with measurements at baseline, 1-month, 4-months and 9-months post-intervention, using online questionnaires. Both versions will

  3. Let’s Take it to the Clouds: The Potential of Educational Innovations, Including Blended Learning, for Capacity Building in Developing Countries

    PubMed Central

    Marrinan, Hannah; Firth, Sonja; Hipgrave, David; Jimenez-Soto, Eliana

    2015-01-01

    In modern decentralised health systems, district and local managers are increasingly responsible for financing, managing, and delivering healthcare. However, their lack of adequate skills and competencies are a critical barrier to improved performance of health systems. Given the financial and human resource, constraints of relying on traditional face-to-face training to upskill a large and dispersed number of health managers, governments, and donors must look to exploit advances in the education sector. In recent years, education providers around the world have been experimenting with blended learning; that is, amalgamating traditional face-to-face education with web-based learning to reduce costs and enrol larger numbers of students. Access to improved information and communication technology (ICT) has been the major catalyst for such pedagogical innovations. We argue that with many developing countries already improving their ICT systems, the question is not whether but how to employ technology to facilitate the continuous professional development of district and local health managers in decentralised settings. PMID:26340485

  4. Development of a radiative cloud parameterization scheme of stratocumulus and stratus clouds which includes the impact of CCN on cloud albedo

    SciTech Connect

    Cotton, W.R.

    1994-01-18

    The objective of this research is to develop a parameterization scheme that is able to dispose or predict changes in stratocumulus cloud cover, atmospheric boundary layer (ABL) stability, liquid water paths (LWPs), and cloud albedo due to changes in sea-surface temperatures, large scale vertical motion and wind shear, and cloud condensation nuclei (CCN). The motivation for developing such a parameterization scheme is that it is hypothesized that anthropogenic sources of CCN can result in increased concentrations of cloud droplets. The higher concentrations of CCN result in higher concentrations of cloud droplets, thereby enhancing cloud albedo which in the absence of other effects will induce a climate forcing opposed to that associated with ``Greenhouse`` warming. As a result of the complicated interactions between cloud microstructure, cloud macrostructure, and cloud radiative transfer, only a limited range of clouds are susceptible to changes in CCN concentrations causing changes in cloud albedo. It is the intent of this research to determine the range of cloud types that are susceptible to albedo changes by anthropogenic CCN and incorporate that information into a cloud parameterization scheme.

  5. Development of a Large Animal Long-Term Intervertebral Disc Organ Culture Model That Includes the Bony Vertebrae for Ex Vivo Studies.

    PubMed

    Grant, Michael; Epure, Laura M; Salem, Omar; AlGarni, Nizar; Ciobanu, Ovidiu; Alaqeel, Motaz; Antoniou, John; Mwale, Fackson

    2016-07-01

    Intervertebral disc (IVD) degeneration is a common cause of low back pain. Testing potential therapeutics in the regeneration of the disc requires the use of model systems. Although several animal models have been developed to investigate IVD degeneration, they are technically challenging to prepare, expensive, present with limitations when performing biomechanical studies on the disc, and are impractical in large-scale screening of novel anabolic and scaffolding agents. An IVD organ culture system offers an inexpensive alternative. In the current paradigm, the bony endplates are removed to allow for nutrient diffusion and maintenance of disc cell viability. Although this is an excellent system for testing biologics, it results in concave cartilage endplates and, as such, requires special platens for loading purposes in a bioreactor as flat ones can overload the annular disc region leading to improper loading. Furthermore, the absence of bone makes it unsuitable for applying complex cyclic loading, a topic of interest in the study of chronic progressive degeneration, as multiaxial loading is more representative of daily forces encountered by the IVD. We have developed and validated a novel long-term IVD organ culture model that retains vertebral bone and is easy to prepare. Our model is ideal for testing potential drugs and alternate-based therapies, in addition to investigating the long-term effects of loading paradigms on disc degeneration and repair. PMID:27216856

  6. Canada/United States Air Quality Agreement: Progress report, 1996

    SciTech Connect

    1996-12-31

    This report builds on the 1992 and 1994 Canada/United States Air Quality Agreement Progress Reports. The report reviews the acid rain control programs, emissions forecasts, and scientific research in both countries; discusses new areas of concern, such as ground-level ozone (smog) and air toxics; and includes the first five-year review of the Air Quality Agreement.

  7. 22 CFR 1422.7 - Agreement for consent election.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Agreement for consent election. 1422.7 Section... REPRESENTATION PROCEEDINGS § 1422.7 Agreement for consent election. (a) All parties desiring to participate in an election being conducted pursuant to this section or § 1422.16, including intervenors who have met...

  8. 22 CFR 1422.7 - Agreement for consent election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Agreement for consent election. 1422.7 Section... REPRESENTATION PROCEEDINGS § 1422.7 Agreement for consent election. (a) All parties desiring to participate in an election being conducted pursuant to this section or § 1422.16, including intervenors who have met...

  9. 44 CFR 6.54 - Agreement to alternative amendments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Agreement to alternative... § 6.54 Agreement to alternative amendments. If the denial of a request to amend a record includes proposed alternative amendments, and if the requestor agrees to accept them, he or she must notify...

  10. 44 CFR 6.54 - Agreement to alternative amendments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Agreement to alternative... § 6.54 Agreement to alternative amendments. If the denial of a request to amend a record includes proposed alternative amendments, and if the requestor agrees to accept them, he or she must notify...

  11. 44 CFR 6.54 - Agreement to alternative amendments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Agreement to alternative... § 6.54 Agreement to alternative amendments. If the denial of a request to amend a record includes proposed alternative amendments, and if the requestor agrees to accept them, he or she must notify...

  12. 46 CFR 535.403 - Form of agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 9 2014-10-01 2014-10-01 false Form of agreements. 535.403 Section 535.403 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE OCEAN COMMON CARRIER... signature as soon as practicable before the effective date. (e) Every agreement shall include a Table...

  13. 12 CFR 211.5 - Edge and agreement corporations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (12 CFR part 204), and other Edge and agreement corporations; (3) Money-market instruments (including... and Q (12 CFR parts 204 and 217) in the same manner and to the same extent as if the Edge or agreement... (12 CFR 208.62). (l) Protection of customer information and consumer information. An Edge or...

  14. 12 CFR 211.5 - Edge and agreement corporations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (12 CFR part 204), and other Edge and agreement corporations; (3) Money-market instruments (including... and Q (12 CFR parts 204 and 217) in the same manner and to the same extent as if the Edge or agreement... (12 CFR 208.62). (l) Protection of customer information and consumer information. An Edge or...

  15. 12 CFR 211.5 - Edge and agreement corporations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Q (12 CFR parts 204 and 217) in the same manner and to the same extent as if the Edge or agreement... (12 CFR part 204), and other Edge and agreement corporations; (3) Money-market instruments (including... (12 CFR 208.62). (l) Protection of customer information and consumer information. An Edge or...

  16. 12 CFR 211.5 - Edge and agreement corporations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and Q (12 CFR parts 204 and 217) in the same manner and to the same extent as if the Edge or agreement... (12 CFR part 204), and other Edge and agreement corporations; (3) Money-market instruments (including... (12 CFR 208.62). (l) Protection of customer information and consumer information. An Edge or...

  17. Museums in the Commercial Marketplace: The Need for Licensing Agreements.

    ERIC Educational Resources Information Center

    Hodes, Scott; Gross, Karen

    1978-01-01

    Discussed are the major features of a Model Licensing Agreement to be used by museums in any commercial reproduction venture. They include rights and obligations of the respective parties, maintenance of quality control, payment of royalties, arbitration, and termination provisions. The Model Licensing Agreement is appended. (JMD)

  18. US-Euratom Nuclear Cooperation Agreement: The eleventh hour

    SciTech Connect

    1995-01-01

    Issues involved in negotiations between the United States and Euratom for renewing the Nuclear Cooperation Agreement are discussed. The Agreement impacts exports to Euratom countries of nuclear material and technology, and US approval of third party transfers of US-origin material, including Japanese reprocessing, to Euratom countries. The US Nuclear Non-Proliferation Act, requiring more stringent safeguards for US-origin materials, is described as a major issue preventing Euratom countries signing the Agreement. Potential impacts of allowing the Agreement to lapse are described, and actions required for renewal are outlined.

  19. The development of a cholesterol biosensor using a liquid crystal/aqueous interface in a SDS-included β-cyclodextrin aqueous solution.

    PubMed

    Munir, Sundas; Park, Soo-Young

    2015-09-17

    Sodium dodecyl sulphate (SDS) including β-cyclodextrin (β-CD) (β-CDSDS) was used to detect cholesterol at the 4-cyano-4'-pentylbiphenyl (5CB)/aqueous interface in transmission electron microscopy (TEM) grid cells. The β-CD acts as a host for SDS (guest). The guest SDS enclosed within the β-CD cavity was replaced with cholesterol by injecting cholesterol solution into the TEM cell at concentrations greater than 3 μM. The replacement of SDS with cholesterol was confirmed by pH measurement and high performance liquid chromatography (HPLC). The SDS excluded from the β-CD altered the planar orientation of the 5CB confined within the TEM grid cell to a homeotropic orientation. This planar-to-homeotropic transition was observed using a polarized optical microscope under crossed polarizers. This convenient TEM grid cell provides a new method for the selective detection of cholesterol without immobilization of the detecting receptors (enzyme, antibody, or aptamer) or the use of sophisticated instruments. PMID:26398428

  20. Pump apparatus including deconsolidator

    DOEpatents

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  1. Assessing agreement between malaria slide density readings

    PubMed Central

    2010-01-01

    limits of agreement, corresponding to Poisson variation, are ± 780 and ± 1,800 parasites/μl, respectively. The focus of this approach on the volume of blood read leads to other conclusions. For example, no matter how large a volume of blood is read, some densities are too low to be reliably detected, which in turn means that disagreements on slide positivity may simply result from within-slide variation, rather than reading errors. Conclusions The proposed method defines limits of acceptable agreement in a way which allows for the natural increase in variability with parasite density. This includes defining the levels of between-reader variability, which are consistent with random variation: disagreements within these limits should not trigger additional readings. This approach merits investigation in other settings, in order to determine both the extent of its applicability, and appropriate numerical values for limits of agreement. PMID:20047679

  2. Influence of long-term altered gravity on the swimming performance of developing cichlid fish: including results from the 2nd German Spacelab Mission D-2

    NASA Astrophysics Data System (ADS)

    Rahmann, H.; Hilbig, R.; Flemming, J.; Slenzka, K.

    This study presents qualitative and quantitative data concerning gravity-dependent changes in the swimming behaviour of developing cichlid fish larvae (Oreochromis mossambicus) after a 9 resp. 10 days exposure to increased acceleration (centrifuge experiments), to reduced gravity (fast-rotating clinostat), changed accelerations (parabolic air craft flights) and to near weightlessness (2nd German Spacelab Mission D-2). Changes of gravity initially cause disturbances of the swimming performance of the fish larvae. With prolonged stay in orbit a step by step normalisation of the swimming behaviour took place in the fish. After return to 1g earth conditions no somersaulting or looping could be detected concerning the fish, but still slow and disorientated movements as compared to controls occurred. The fish larvae adapted to earth gravity within 3-5 days. Fish seem to be in a distinct early developmental stages extreme sensitive and adaptable to altered gravity. However, elder fish either do not react or show compensatory behaviour e.g. escape reactions.

  3. Development of a Validated LC Method for Separation of Process-Related Impurities Including the R-Enantiomer of S-Pramipexole on Polysaccharide Chiral Stationary Phases.

    PubMed

    Ramisetti, Nageswara Rao; Kuntamukkala, Ramakrishna; Arnipalli, Manikanta Swamy

    2015-07-01

    Despite the availability of a few methods for individual separation of S-pramipexole from its process-related impurities, no common liquid chromatography (LC) method is reported so far in the literature. The present article describes the development of a single-run LC method for simultaneous determination of S-pramipexole and its enantiomeric and process-related impurities on a Chiralpak AD-H (150 x 4.6 mm, 5μm) column using n-hexane/ethanol/n-butylamine (75:25:0.1 v/v/v) as a mobile phase in an isocratic mode of elution at a flow rate of 1.2 ml/min at 30°C. The chromatographic eluents were monitored at a wavelength of 260 nm using a photodiode array detector. Excellent enantioseparation with good resolutions (Rs ≥ 2.88) and peak shapes (As ≤ 1.21) for all analytes was achieved. The proposed method was validated according to International Conference Harmonization (ICH) guidelines in terms of accuracy, precision, sensitivity, and linearity. Limits of quantification of impurities (0.25-0.55 μg/ml) indicate the highest sensitivity achievable by the proposed method. The method has an advantage of selectivity and suitability for routine determination of not only chiral impurity but also all possible related substances in active pharmaceutical ingredients of S-pramipexole. PMID:25966024

  4. Emerging importance of mismatch repair components including UvrD helicase and their cross-talk with the development of drug resistance in malaria parasite.

    PubMed

    Ahmad, Moaz; Tuteja, Renu

    2014-12-01

    Human malaria is an important parasitic infection responsible for a significant number of deaths worldwide, particularly in tropical and subtropical regions. The recent scenario has worsened mainly because of the emergence of drug-resistant malaria parasites having the potential to spread across the world. Drug-resistant parasites possess a defective mismatch repair (MMR); therefore, it is essential to explore its mechanism in detail to determine the underlying cause. Recently, artemisinin-resistant parasites have been reported to exhibit nonsynonymous single nucleotide polymorphisms in genes involved in MMR pathways such as MutL homolog (MLH) and UvrD. Plasmodium falciparum MLH is an endonuclease required to restore the defective MMR in drug-resistant W2 strain of P. falciparum. Although the role of helicases in eukaryotic MMR has been questioned, the identification and characterization of the UvrD helicase and their cross-talk with MLH in P. falciparum suggests the possible involvement of UvrD in MMR. A comparative genome-wide analysis revealed the presence of the UvrD helicase in Plasmodium species, while it is absent in human host. Therefore, PfUvrD may emerge as a suitable drug target to control malaria. This review study is focused on recent developments in MMR biochemistry, emerging importance of the UvrD helicase, possibility of its involvement in MMR and the emerging cross-talk between MMR components and drug resistance in malaria parasite. PMID:25771870

  5. Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.

    PubMed

    Schantz, Michele M; Benner, Bruce A; Heckert, N Alan; Sander, Lane C; Sharpless, Katherine E; Vander Pol, Stacy S; Vasquez, Y; Villegas, M; Wise, Stephen A; Alwis, K Udeni; Blount, Benjamin C; Calafat, Antonia M; Li, Zheng; Silva, Manori J; Ye, Xiaoyun; Gaudreau, Éric; Patterson, Donald G; Sjödin, Andreas

    2015-04-01

    Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers' Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants. PMID:25651899

  6. Limiting technology by negotiated agreement

    SciTech Connect

    Carnesale, A.

    1983-01-01

    The author concentrates on anti-ballistic missile (ABM) systems as an example of a continuing effort to limit technology by negotiated agreement. He first discusses the ABM treaty of 1972, ratified by both the US and the USSR. Afterwards, he briefly treats each of the following: ballistic missile defense (BMD) dilemmas; nature of the BMD choice; technology; economics; deterrence; nuclear warfighting; relations with allies; arms control; Star Wars; and on limiting technology.

  7. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  8. Evaluation of clustering of new intramammary infections in the bovine udder, including the impact of previous infections, herd prevalence, and somatic cell count on their development.

    PubMed

    Reyher, K K; Dohoo, I R; Muckle, C A

    2013-01-01

    Evidence in the literature exists to support the theory that mastitis and intramammary infection (IMI) tend to cluster within herds, within cows, and within quarters, facts which may have overarching ramifications on mastitis management in modern dairy herds. Most previous studies, however, have been carried out on prevalent IMI instead of new IMI (NIMI), although reducing incidence of NIMI is a major step toward controlling mastitis. The Canadian Bovine Mastitis Research Network (Saint-Hyacinthe, QC, Canada) has a large mastitis database derived from a 2-yr data collection on a national cohort of dairy farms, and data from this initiative were used to investigate the effect of clustering on the acquisition of NIMI. Longitudinal milk samplings of clinically normal udders taken over several 6-wk periods as well as samples from cows pre-dry-off and postcalving were used (n=73,772 quarter milk samples). Multilevel logistic models were used to evaluate the effect of location of IMI in quarters of the bovine udder previous to occurrence of an NIMI with Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium spp. Several factors were investigated, including the number and location of quarters infected with the pathogen of interest before occurrence of an NIMI, the number of quarters infected with any other pathogen before occurrence of an NIMI (a measure of susceptibility), somatic cell count of the quarter before occurrence of an NIMI, somatic cell count of the other 3 quarters before occurrence of an NIMI, prevalence of the specific pathogen in the herd, and the average somatic cell count of the herd. The amount of variation occurring at different levels (herd, cow, and quarter) for the various pathogens was also calculated. The presence of an IMI in the ipsilateral quarter was associated with an elevated risk of an NIMI occurring for all pathogens investigated. Risk of an NIMI increased considerably as herd prevalence of the pathogen rose

  9. 78 FR 8533 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Agreement. Parties: Crowley Latin America Services, LLC and Dole Ocean Cargo Express, Inc. Filing Party... scope of the agreement, clarifies language in the agreement, and makes technical corrections to...

  10. 77 FR 38288 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... . Agreement No.: 012177. Title: MSC/Maersk Line U.S.-Panama Space Charter Agreement. Parties: Mediterranean... agreement authorizes MSC to charter space to Maersk Line in the trade between ports in Panama and ports...

  11. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  12. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  13. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  14. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  15. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  16. 78 FR 15951 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... agreement. Agreement No.: 012196. Title: MSC/CSAV Ecuador--North Europe Vessel Sharing Agreement. Parties... on the U.S. East Coast on the one hand, and from ports on the U.S. East Coast to Panama and...

  17. 75 FR 20849 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... geographic scope of the Agreement. Agreement No.: 011830-008. Title: Indamex Cross Space Charter, Sailing and... Limited Slot Charter and Sailing Agreement. Parties: Tropical Shipping & Construction Co., Ltd. and...

  18. 75 FR 11180 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ....gov . Agreement No.: 011730-003. Title: GWF/Dole Space Charter and Sailing Agreement. Parties: Dole... China-US Pacific Coast Two-Loop Space Charter, Sailing and Cooperative Working Agreement. Parties:...

  19. 78 FR 54646 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    .... Agreement No.: 012220. Title: Crowley/Seaboard Space Charter and Sailing Agreement. Parties: Crowley Latin.../America Cruise Ferries, Inc. Space Charter and Sailing Agreement. Parties: Crowley Latin America...

  20. 75 FR 33634 - Klamath Hydroelectric Settlement Agreement, Including Secretarial Determination on Whether to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ...'s Klamath Project were substantially reduced. --In 2002, returning adult salmon suffered a major die-off. --In 2006, the commercial salmon fishing season was closed along 700 miles of the West Coast...

  1. FETC/EPRI BIOMASS COFIRING COOPERATIVE AGREEMENT

    SciTech Connect

    D. TILLMAN; E. HUGHES

    1998-08-01

    This quarter much progress was made in promoting cofiring through the many FETC/EPRI backed projects. During January 1, 1998 to March 31st, 1998 significant contractual agreements were arranged for future testing and analyses of previous testing were conducted. Most notable was the analysis done on the testing run at the Tennessee Valley Authority�s Colbert Fossil Plant that showed no significant impacts to the plant boiler due to cofiring. Northern Indiana Public Service Company also identified Bailly #7 as the site of the next series of tests using their plants. Other work done on these projects primarily focused on continued cofiring development. This report summarizes the activities during the first quarter in 1998 of the FETC/EPRI Biomass Cofiring Cooperative Agreement. It focuses upon reporting the results of testing in order to highlight the progress at utilities.

  2. Development of a novel ArcCHECK{sup Trade-Mark-Sign} insert for routine quality assurance of VMAT delivery including dose calculation with inhomogeneities

    SciTech Connect

    Fakir, H.; Gaede, S.; Mulligan, M.; Chen, J. Z.

    2012-07-15

    insert depending on the inhomogeneity configuration and measurement location. SmartArc{sup Registered-Sign} and RapidArc{sup Registered-Sign} plans had similar plan quality but RapidArc{sup Registered-Sign} plans had significantly higher monitor units (up to 70%). Conclusions: A versatile, nonhomogeneous insert was developed for ArcCHECK{sup Trade-Mark-Sign} for an easy and quick evaluation of dose calculations with nonhomogeneous media and for comparison of different treatment planning systems. The device was tested for SmartArc{sup Registered-Sign} and RapidArc{sup Registered-Sign} plans for lung SBRT, showing the uncertainties of dose calculations with inhomogeneities. The new insert combines the convenience of the ArcCHECK{sup Trade-Mark-Sign} and the possibility of assessing dose distributions in inhomogeneous media.

  3. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any...

  4. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any...

  5. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any...

  6. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any...

  7. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any...

  8. 48 CFR 970.3501-1 - Sponsoring agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Sponsoring agreements. 970.3501-1 Section 970.3501-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Research and Development Contracting 970.3501-1 Sponsoring agreements. (a) The...

  9. UNITED STATES/GERMAN TECHNICAL BILATERAL AGREEMENT: PAST, PRESENT & FUTURE

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) and the German Federal Ministry of Education and Research (BMBF) entered into a Bilateral Agreement in 1990 to study each country's efforts in developing and demonstrating remedial technologies. The bilateral agreement is being impl...

  10. 42 CFR 124.607 - Agreements with State agencies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Agreements with State agencies. 124.607 Section 124.607 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service § 124.607 Agreements with...

  11. 42 CFR 124.607 - Agreements with State agencies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Agreements with State agencies. 124.607 Section 124.607 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service § 124.607 Agreements with...

  12. 42 CFR 124.607 - Agreements with State agencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Agreements with State agencies. 124.607 Section 124.607 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service § 124.607 Agreements with...

  13. 42 CFR 124.607 - Agreements with State agencies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Agreements with State agencies. 124.607 Section 124.607 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service § 124.607 Agreements with...

  14. 48 CFR 742.770 - Negotiated indirect cost rate agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Negotiated indirect cost rate agreement. 742.770 Section 742.770 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 742.770 Negotiated indirect cost rate agreement. Except for...

  15. 22 CFR 204.32 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 204.32 Section 204.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HOUSING GUARANTY STANDARD TERMS AND CONDITIONS Covenants § 204.32 Change in agreements. Neither the Lender nor any Assignee will consent to any change...

  16. 22 CFR 205.1 - Grants and cooperative agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Grants and cooperative agreements. 205.1 Section 205.1 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PARTICIPATION BY RELIGIOUS ORGANIZATIONS IN USAID PROGRAMS § 205.1 Grants and cooperative agreements. (a) Religious organizations are eligible, on the same basis as any other...

  17. Regulation by Agreement: The Case of Private Higher Education.

    ERIC Educational Resources Information Center

    Finkin, Matthew W.

    1981-01-01

    Over the past decade, two developments have greatly affected the conduct of affairs in academic institutions in the United States: the increasing role of the courts and the growth of collective bargaining. Collective agreement, impasse and unilateral action, the strike, and the expiration of the collective agreement are discussed. (MLW)

  18. 48 CFR 235.017-1 - Sponsoring agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Sponsoring agreements. 235.017-1 Section 235.017-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.017-1 Sponsoring agreements....

  19. 24 CFR 982.317 - Lease-purchase agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... homeownership premium (e.g., increment of value attributable to the value of the lease-purchase right or... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Lease-purchase agreements. 982.317...-purchase agreements. (a) A family leasing a unit with assistance under the program may enter into...

  20. 24 CFR 982.317 - Lease-purchase agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... homeownership premium (e.g., increment of value attributable to the value of the lease-purchase right or... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Lease-purchase agreements. 982.317...-purchase agreements. (a) A family leasing a unit with assistance under the program may enter into...

  1. 24 CFR 982.317 - Lease-purchase agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... homeownership premium (e.g., increment of value attributable to the value of the lease-purchase right or... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Lease-purchase agreements. 982.317...-purchase agreements. (a) A family leasing a unit with assistance under the program may enter into...

  2. 24 CFR 982.317 - Lease-purchase agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... homeownership premium (e.g., increment of value attributable to the value of the lease-purchase right or... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Lease-purchase agreements. 982.317...-purchase agreements. (a) A family leasing a unit with assistance under the program may enter into...

  3. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Cooperative agreement. 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement....

  4. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Cooperative agreement. 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement....

  5. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Cooperative agreement. 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement....

  6. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Cooperative agreement. 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement....

  7. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Cooperative agreement. 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement....

  8. Temporary agency contracts: what should they include?

    PubMed

    Sferrella, Sheila M

    2002-01-01

    The AHRA Board committed to provide some tools to help our members with agency contracts. This article provides the sections for a contract and what they should include. Of course, the language will have to comply with your organization's requirements. To comply with HIPAA regulations for contracts, I've also included language for business associates. JCAHO requires that the following documentation be on file for all contracted personnel: 1. Hospital job description or formal contract outlining the job responsibilities. 2. All licenses, certifications and registrations are reviewed and a process is developed to ensure that they remain current. 3. Competency is evaluated and maintained. 4. Evidence that personnel received a general orientation. 5. Evidence that personnel received a departmental orientation. 6. Safety and infection control standards must be met. In order to aid with compliance when utilizing contracted personnel, my organization developed a Contractor Personnel Administrative Compliance Checklist, which identifies requirements for compliance, a reference for assistance, and places to record that the requirement has been met for each of the areas listed in the previous item. Our standard contract includes sections on general definition of engagement, credentials and work experience; health, including immunization and drug testing; corporation; JCAHO; terms of the contract; and, non-disclosure of information. A business associate agreement may be necessary to comply with HIPAA regulations. Using the template has made my job much easier than trying to read each contract that crosses my desk. If an agency refuses to sign our contract, then we do not conduct business with that company. If an agency requests changes to the contract, depending on the language, we may or may not agree to it. This information is not intended to be legal advice, but rather an educational overview. As with any contract, the reader should consult with legal counsel at his or her

  9. Types of contracts and agreements guide. Part 1

    SciTech Connect

    Not Available

    1981-05-01

    The purpose of this volume is to be helpful in providing a comprehensive introduction to a wide variety of contract types and agreements, including a consideration of small purchase procedures and multiyear procurement. In both format and content, it is designed to help those persons who influence the determination of the types of contracts and agreements to be employed in acquiring goods and services for the Department of Energy. Information is presented on selecting and negotiating types of contract compensation arrangements; fixed-price type contract compensation arrangements, including small purchases and multiyear procurement; cost-reimbursement type contract compensation arrangements; other types of contract compensation agreements; and basic agreements and basic ordering agreements. (LCL)

  10. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 181.5 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency, including the Department of State, that concludes an international agreement within the meaning of the...

  11. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  12. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  13. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  14. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  15. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 181.5 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency, including the Department of State, that concludes an international agreement within the meaning of the...

  16. 14 CFR 1274.203 - Solicitations/cooperative agreement notices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., occupational health, security (including information technology security), environmental, export control, and... agreement information. Any draft documentation released for comment shall contain all factors/subfactors... selection. (2) During the information gathering process, comments may be invited from potential...

  17. 14 CFR 1274.203 - Solicitations/cooperative agreement notices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to the success of the project, for some projects the recipient's statement of work may be included as... suitability of the requested resource(s) to the work to be performed under the cooperative agreement....

  18. 14 CFR 1274.203 - Solicitations/cooperative agreement notices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to the success of the project, for some projects the recipient's statement of work may be included as... suitability of the requested resource(s) to the work to be performed under the cooperative agreement....

  19. 40 CFR 790.60 - Contents of consent agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Laboratory Practice (GLP) regulations (40 CFR part 792). (8) Schedules with reasonable deadlines for... data included in consent agreements will be based on the TSCA test guidelines in 40 CFR parts 796,...

  20. Developing Skills through Partnerships: Symposium Report

    ERIC Educational Resources Information Center

    Colleges Ontario, 2011

    2011-01-01

    In November 2005, the province of Ontario and the federal government signed two historic agreements--the Canada-Ontario Labour Market Development Agreement and the Canada-Ontario Labour Market Partnership Agreement. One year later, on Nov. 24, 2006, key labour market stakeholders, including users, delivery agents and government came together to…