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Sample records for agreement nos de-fc52-08na28302

  1. Simulations of Cone-in-Shell Targets for Integrated Fast-Ignition Experiments on OMEGA

    NASA Astrophysics Data System (ADS)

    Solodov, A. A.; Theobald, W.; Anderson, K. S.; Shvydky, A.; Betti, R.; Myatt, J. F.; Stoeckl, C.; Stephens, R. B.

    2012-10-01

    Integrated cone-in-shell fast-ignition experiments on OMEGA will benefit from improved performance of the OMEGA EP laser, including higher contrast, higher energy, and a smaller focus. A new target design has been developed with a 60-μm-thick, low-Z aluminum cone tip. A very thin (˜2-μm) gold layer inside the cone tip is used to shield the radiation. Hydrodynamic DRACO simulations predict that this design is more resilient against shock than the previous gold-only design and the cone-tip breakout is delayed by about 100 ps. DRACO simulations are confirmed by the recent 8-keV flash radiography and shock-breakout measurements on OMEGA. Simulations of core heating by fast electrons generated by the OMEGA EP pulse using the hybrid particle-in-cell code LSP integrated with DRACO are performed. The electrical resistivity mismatch between the aluminum tip and the surrounding plastic plasma is shown to collimate fast electrons into the assembled fuel. Energy deposition of fast electrons in the compressed core is investigated. Core heating and neutron yield are computed. This work was supported by the U.S. Department of Energy under Cooperative Agreement Nos. DE-FC52-08NA28302 and DE-FC02-04ER54789.

  2. Shock-Ignition Studies on OMEGA

    NASA Astrophysics Data System (ADS)

    Hohenberger, M.; Theobald, W.; Anderson, K. S.; Betti, R.; Meyerhofer, D. D.; Stoeckl, C.; Casner, A.; Ribeyre, X.; Schurtz, G.

    2010-11-01

    Recent theoretical workootnotetextR. Betti et al., Phys. Rev. Lett. 98, 155001 (2007) has shown that the gain in an inertial confinement fusion (ICF) experiment can be significantly increased through separation of the compression and ignition stage by launching a strong, spherically convergent shock at the end of a compression pulse. This scheme, referred to as shock ignition, reduces the energy required for ignition compared to ``conventional'' ICF or fast ignition. Through potentially relaxed requirements for the ignitor-shock spherical symmetry, it can be carried out in a polar-drive configuration and is therefore applicable to the National Ignition Facility. The results of a series of spherical and planar-target experiments on OMEGA to study the shock-ignition technique and to infer the shock strength, hot-electron generation, and light reflectivity at the high intensities relevant to shock ignition will be presented. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement Nos. DE-FC52-08NA28302 and DE-FC02-04ER54789.

  3. LLE 2009 annual report, October 2008-September 2009

    SciTech Connect

    none, none

    2010-01-01

    The fiscal year ending September 2009 (FY2009) concluded the second year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year. It also reports on LLE’s progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the National Laser Users’ Facility (NLUF), and other external users; and programs focusingon the education of high school, undergraduate, and graduate students during the year.

  4. Magnetic Field Generation by the Nonlinear Rayleigh--Taylor Instability in Laser-Driven Planar Plastic Targets

    NASA Astrophysics Data System (ADS)

    Gao, L.; Igumenshchev, I. V.; Hu, S. X.; Stoeckl, C.; Froula, D. H.; Nilson, P. M.; Davies, J. R.; Betti, R.; Meyerhofer, D. D.; Haines, M. G.

    2012-10-01

    Magnetic field generation during the nonlinear phase of the Rayleigh--Taylor (RT) instability in an ablatively driven plasma using ultrafast laser-driven proton radiography has been measured. Thin plastic foils were irradiated with ˜4-kJ, 2.5-ns laser pulses focused to an intensity of ˜10^14 W/cm^2 on the OMEGA EP Laser System. Target modulations were seeded by laser nonuniformities and amplified during target acceleration by the RT instability. The experimental data show the hydrodynamic evolution of the target and MG-level magnetic fields generated in the broken foil. The experimental data are in good agreement with predictions from 2-D magnetohydrodynamic simulations. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  5. Recent Experimental Results from Cryogenic Implosions on OMEGA

    NASA Astrophysics Data System (ADS)

    Sangster, T. C.; Goncharov, V. N.; Radha, P. B.; Betti, R.; Boehly, T. R.; Glebov, V. Yu.; Hu, S. X.; McCrory, R. L.; McKenty, P. W.; Meyerhofer, D. D.; Seka, W.; Smalyuk, V. A.; Frenje, J. A.; Petrasso, R. D.; Shvarts, D.

    2008-11-01

    The implosion performance of energy-scaled cryogenic D2 and DT targets on the 60-beam OMEGA laser is important for understanding the physics of highly compressed fuel and the validation of ignition designs for the NIF. Recent experiments have demonstrated good performance using a multi-shock drive that has been tuned based on cryogenic cone-in-shell targets. Fuel areal densities are now consistently exceeding 80% of the 1-D prediction, while the yields are between 10% and 20% of 1-D predictions. These results demonstrate the benefit (and necessity) of an independent shock-timing platform. This talk will present the latest implosion performance results and potentially show the first cryogenic-fuel-core radiographs using a short pulse beam from the new OMEGA EP Laser Facility. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  6. Initial Experiments Using the OMEGA EP Laser System

    NASA Astrophysics Data System (ADS)

    Meyerhofer, D. D.; Boehly, T. R.; Betti, R.; Glebov, V. Yu.; Kelly, J. H.; Knauer, J. P.; Loucks, S. J.; McCrory, R. L.; Morse, S. F. B.; Myatt, J. F.; Nilson, P. M.; Regan, S. P.; Sangster, T. C.; Smalyuk, V. A.; Stoeckl, C.; Theobald, W.

    2008-11-01

    The OMEGA EP Laser System was completed in April 2008 as a significant enhancement of the OMEGA Laser System. It consists of four NIF-like beamlines, two of which can be operated as high-energy petawatt laser beams. The initial experimental plan includes developing bright backlighter sources (line and bremsstrahlung), isochoric heating, hot-electron conversion-efficiency measurements (to compare with results from other systems), long-pulse LPI at NIF-relevant scale lengths, and fast-ignition integrated experiments using cone-in-shell targets. Backlighter experiments are designed to optimize the fluence for cryogenic implosion core radiography. This talk will describe the current status of the OMEGA EP Laser System and some initial target-physics experiments. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  7. Polar-Drive--Ignition Experimental Plan on the NIF

    NASA Astrophysics Data System (ADS)

    Meyerhofer, D. D.; Froula, D. H.; Goncharov, V. N.; Igumenshchev, I. V.; Loucks, S. J.; McKenty, P. W.; McCrory, R. L.; Radha, P. B.; Sangster, T. C.

    2012-10-01

    The University of Rochester's Laboratory for Laser Energetics has proposed a multi-campaign series of experiments on the National Ignition Facility (NIF)footnotetext E. I. Moses et al., Phys. Plasmas 16, 041006 (2009). to develop polar-drive ignition.footnotetext S. Skupsky et al., Phys. Plasmas 11, 2763 (2004). Polar drive is predicted to couple significantly more energy to the compressed core than the baseline indirect-drive approach. This presentation provides an overview of the plan to achieve polar-drive ignition on the NIF and describes the initial experiments that can be performed without changes in the NIF infrastructure. The first proposed experiments will assess the symmetry of moderate convergence ratio, polar-driven capsule implosions. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  8. LLE 2010 Annual Report October 2009 - September 2010

    SciTech Connect

    2011-01-01

    The fiscal year ending September 2010 (FY10) concluded the third year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year including work on the National Ignition Campaign (NIC). It also reports on LLE's progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the NIC and high-energy density (HED) campaigns, the National Laser Users Facility (NLUF), and for other external users; and programs focusing on the education of high school, undergraduate, and graduate students during the year.

  9. Integrated Simulations of Hot-Electron Transport and Ignition for Direct-Drive, Fast-Ignition Targets

    NASA Astrophysics Data System (ADS)

    Solodov, A.

    2008-11-01

    A thorough understanding of future integrated fast-ignition experiments combining compression and heating for high-density thermonuclear fuel require hybrid (fluid+particle) simulations of the implosion and ignition process. Very different spatial and temporal scales need to be resolved to model the entire fast-ignition experiment. The 2-D axisymmetric hydrocode DRACO and the 2-D/3-D hybrid-PIC code LSP have been integrated to simulate the implosion and heating of direct-drive fast-ignition fusion targets. DRACO includes the physics required to simulate compression, ignition, and burn of fast-ignition targets. LSP simulates the transport of hot electrons from the place where they are generated by a petawatt laser pulse to the dense fuel core where their energy is absorbed. The results of integrated simulations of optimized spherically symmetric and cone-in-shell DT, high-gain, fast-ignition targets will be presented. The minimum energy required for ignition is found for hot electrons with a realistic angular spread and Maxwellian energy-distribution function. The results from simulations of cone-in-shell plastic targets designed for fast-ignition experiments on OMEGA EP will be presented. Target heating and neutron yield are computed. Resistive Weibel instability is found to break the hot-electron beam into filaments. The global self-generated resistive magnetic field of the beam is found to collimate the hot electrons. The self-generated field increases the coupling efficiency of hot electrons with the target core and reduces the minimum energy required for ignition. This work was supported by the U.S. Department of Energy under Cooperative Agreement Nos. DE-FC02-04ER54789 and DE-FC52-08NA28302. Contributors: K.S. Anderson, R. Betti, V. Gotcheva, J.F. Myatt, J.A. Delettrez, S. Skupsky. P. B. Radha et al., Phys. Plasmas 12, 056307 (2005). D. R. Welch et al., Phys. Plasmas 13, 063105 (2006). R. Betti and C. Zhou, Phys. Plasmas 12, 110702 (2005). B. Chrisman, Y

  10. Transport of Energetic Electrons Produced from Two-Plasmon Decay in the 1-D Hydrodynamic Code LILAC

    NASA Astrophysics Data System (ADS)

    Delettrez, J. A.; Gocharov, V. N.; Radha, P. B.; Stoeckl, C.; Maximov, A. V.; Sangster, T. C.; Frenje, J. A.; Shvarts, D.

    2008-11-01

    The effect of two-plasmon-decay electrons on direct-drive cryogenic implosions on the OMEGA laser is modeled. The electrons are created at the quarter-critical surface when a threshold depending on laser intensity and local thermal-electron conditions is attained. The fraction of the absorbed laser energy is a parameter that depends exponentially on the threshold condition and saturates at laser intensities of 10^15 W/cm^2. The source distribution is a Maxwellian with a temperature scaling inferred from hard x-ray measurements. The electrons are transported with a multi-group diffusion model for the low energy electrons and a straight-line model for the high-energy electrons. Simulation results from warm plastic and cryogenic implosions are compared with the following diagnostics: the hard x-ray emission, the fast-ion spectrum, and the neutron-averaged areal density at stagnation. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  11. Results of a supersonic, single-mode, shockwave-driven Kelvin-Helmholtz instability experiment

    NASA Astrophysics Data System (ADS)

    Wan, W. C.; Malamud, G.; di Stefano, C. A.; Trantham, M. R.; Klein, S. R.; Shimony, A.; Shvarts, D.; Kuranz, C. C.; Drake, R. P.

    2014-10-01

    The Kelvin-Helmholtz instability is a hydrodynamic process that causes mixing at an interface with shear flow. It is prevalent in many high-energy-density systems such as fusion research, core-collapse supernovae, and protoplanetary disks. Although it is common to simplify the Euler equations by assuming incompressibility, this assumption does not account for the inhibited growth rate found in supersonic flows. Here, we present the first laboratory observations of single-mode, compressible Kelvin-Helmholtz instability growth. This experiment was performed at the OMEGA-EP facility using three beams stitched into a 28 ns square pulse to sustain a shockwave in low-density foam. The shockwave generated shear along the interface between the foam and a high-density plastic, seeded with a precisely machined single-mode sinusoidal perturbation. The system was diagnosed using radiography with a spherically bent crystal. This work is funded by the U.S. Department of Energy, through the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, Grant Number DE-NA0001840, the National Laser User Facility Program, Grant Number DE-NA0000850, and the Laboratory for Laser Energetics, University of Rochester by the NNSA/OICF under Cooperative Agreement No. DE-FC52-08NA28302.

  12. Optimization with Telios of the Polar-Drive Point Design for the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Collins, T. J. B.; Marozas, J. A.; McKenty, P. W.

    2012-10-01

    Polar drivefootnotetextS. Skupsky et al., Phys. Plasmas 11, 2763 (2004). (PD) will make it possible to conduct direct-drive--ignition experiments at the National Ignition Facilityfootnotetext G. H. Miller, E. I. Moses, and C. R. Wuest, Opt. Eng. 43, 2841 (2004). while the facility is configured for x-ray drive. A PD-ignition design has been developedfootnotetextT. J. B. Collins et al., Phys. Plasmas 19, 056308 (2012). achieving high gain in simulations including single- and multiple-beam nonuniformities, and ice and outer-surface roughness. This design has been further optimized to reduce the in-flight aspect ratio and implosion speed, increasing target stability while maintaining moderately high thermonuclear gains. The dependence of target properties on implosion speed has been examined using the optimization shell Telios. Telios has the capability to drive complex radiation--hydrodynamic simulations and optimized results over an arbitrarily large parameter space, including ring pointing angles, spot-shape parameters, target dimensions, pulse timing, and relative pulse energies. Telios is capable of extracting output from a variety of sources and combining them to form arbitrarily complex, user-specified metrics. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  13. Observations of vortex merger and growth reduction in a dual-mode, supersonic Kelvin-Helmholtz instability experiment

    NASA Astrophysics Data System (ADS)

    Wan, Willow; Malamud, Guy; Shimony, Assaf; Trantham, Matt; Klein, Sallee; Shvarts, Dov; Kuranz, Carolyn; Drake, R. Paul

    2015-11-01

    The Kelvin-Helmholtz instability (KHI) generates vortical structures and turbulence at an interface with shear flow. This instability is ubiquitous in natural and engineering systems including astrophysical environments and laboratory plasmas. Detailed measurements of modulation amplitude growth reduction and vortex merger evolving from well-defined initial conditions can benchmark hydrodynamic models and theories. This experiment provides the first measurements of the vortex merger rate of well-characterized seed perturbations evolving under the influence of the KHI in a supersonic flow. These data were obtained by utilizing a sustained laser pulse to drive a steady shockwave into low-density carbon foam, introducing shear along a precision-machined plastic interface. The evolution and merger of the modulations was measured with x-ray radiography and reproduced with 2D hydrodynamic simulations. This work is funded by the U.S. Department of Energy, through the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, grant number DE-NA0001840, and the National Laser User Facility Program, grant number DE-NA0002032, and through the Laboratory for Laser Energetics, University of Rochester by the NNSA/OICF under Cooperative Agreement No. DE-FC52-08NA28302.

  14. Measurements of X-ray spectra from irradiated gold foils at the OMEGA Laser facility

    NASA Astrophysics Data System (ADS)

    Davis, Joshua; Keiter, Paul; Drake, Paul; Klein, Sallee; Fein, Jeff

    2014-10-01

    In many HED systems high intensity x-rays can be used to measure plasma properties such as density and temperature. At the OMEGA laser facility, these X-rays are produced by irradiating a metal foil with high-intensity lasers, which heats the foil and causes it to act as a quasi-continuum x-ray source for radiography or absorption spectroscopy. As this emission is quasi-continuous and the transmission of x-rays through a material varies with photon energy a well-characterized x-ray source is vital. Therefore, in order to optimize diagnostics reliant upon x-rays it is necessary to gain a better understanding of how the x-ray emission from these targets varies over time and varying beam energy. We will present experimental results studying the effect that beam energy and pulse length have on M-band and sub-keV x-ray emission generated from a 5 μm thick gold disk using time-resolved spectroscopy and a Henway crystal spectrometer. This work is funded by the U.S. Department of Energy, through the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, Grant Number DE-NA0001840, and the National Laser User Facility Program, Grant Number DE-NA0000850, and through the Laboratory for Laser Energetics, University of Rochester by the NNSA/OICF under Cooperative Agreement No. DE-FC52-08NA28302.

  15. Shockwave-Driven, Supersonic Kelvin-Helmholtz Instability Experiment on OMEGA-EP

    NASA Astrophysics Data System (ADS)

    Wan, Wesley; Malamud, Guy; di Stefano, Carlos; Kuranz, Carolyn; Drake, R. Paul

    2013-10-01

    Hydrodynamic instabilities are commonly encountered in a variety of high-energy-density systems, including fusion experiments and various astrophysical processes. Shear flow at a fluid interface gives rise to the Kelvin-Helmholtz instability, which then results in mixing between the layers. This talk will cover a recent experiment performed at the OMEGA-EP facility that studied the dampening of the Kelvin-Helmholtz instability as a result of compressibility effects in a high convective Mach number regime. A laser-driven shockwave was used to create shear flow between a low-density foam and high-density plastic. The instability growth was assisted by seeded, single-mode perturbations of varied wavelengths. Our primary diagnostic was x-ray radiography. This work is funded by the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, grant number DE-FG52-09NA29548, and by the National Laser User Facility Program, grant number DE-NA0000850, with additional support provided under Cooperative Agreement No. DE-FC52-08NA28302 through the Laboratory for Laser Energetics, University of Rochester.

  16. Probing Ultrafast Processes in Intense Laser--Matter Interactions

    NASA Astrophysics Data System (ADS)

    Hu, S. X.

    2012-06-01

    This talk reports on computational studies of using sub-femtosecond/attosecond extreme ultraviolet and soft-x-ray pulses to probe ultrafast processes in intense laser interactions with atoms, molecules, and plasmas. By developing and optimizing the finite-element discrete-variable-representation (FEDVR) combined with the real-space product (RSP) algorithm, a powerful computational method is generated, enabling one to explore transient processes in quantum, few-body systems non-perturbatively driven by strong electromagnetic fields. These studies include attosecond photoelectron microscopy of molecular structures, ultrafast probing ion--atom collisions, as well as exploring electron correlations in single-/double-ionization of helium in intense laser fields. Detailed discussions on what has been learned and what can be done in experiments will be presented. This work was partially supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302, the University of Rochester, and the New York State Energy Research and Development Authority. The support of DOE does not constitute an endorsement by DOE of the views expressed in this article. Computations have been conducted utilizing the Kraken Supercomputer of the National Institute of Computational Sciences (NICS) at Oak Ridge National Laboratory.

  17. Thomson-Scattering Measurements of Ion-Acoustic Wave Amplitudes Driven by the Two-Plasmon-Decay Instability

    NASA Astrophysics Data System (ADS)

    Follett, R. K.; Michel, D. T.; Myatt, J. F.; Hu, S. X.; Yaakobi, B.; Froula, D. H.

    2012-10-01

    Thomson scattering was used to measure enhanced ion-acoustic waves (IAW's) driven by the two-plasmon-decay (TPD) instability. The IAW amplitude scales with the 3/2φ emission (a TPD signature). Up to 20 beams with 860-μm-diam laser spots generated by 2-ns-long pulses of 3φ (0.351-μm) light with overlapped intensities up to 4 x 10^14 W/cm^2 were used to produce ˜300-μm density-scale lengths. The IAW amplitudes were measured using 4φ Thomson scattering near 3φ quarter-critical densities. Time-resolved 3/2φ spectroscopy was used to compare the amplitude of 3/2φ emission to the IAW amplitude. QZAKfootnotetext K. Y. Sanbonmatsu et al., Phys. Rev. Lett. 82, 932 (1999).^,footnotetext K. Y. Sanbonmatsu et al., Phys. Plasmas 7, 2824 (2000). modeling shows a similar onset threshold and wave amplitude as the experiments. The model suggests that the source of the IAW growth is from the beating of electron-plasma waves, which drive density perturbations through the ponderomotive force. This conclusion is supported by the experimental geometry. This process is shown to be a saturation mechanism for TPD from simulations.footnotetext R. Yan et al., Phys. Rev. Lett. 103, 175002 (2009). This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  18. Shock-Timing Measurements in ICF Targets Filled with Liquid Deuterium

    NASA Astrophysics Data System (ADS)

    Boehly, Thomas; Goncharov, Valeri; Barrios, Maria; Frantanduono, Dayne; Hu, Suxing; Collins, Timothy; Morozas, John; Sangster, Thomas; Meyerhofer, David; Celliers, Peter; Robey, Harry; Hicks, Damien; Collins, Gilbert

    2011-06-01

    High-performance ICF target designs use multiple shocks to condition the shell before it is imploded. Accurate timing of these shocks is critical to target performance. We report on experiments on the OMEGA Laser where up to four spherical shocks were observed in directly driven spherical targets filled with liquid deuterium. The measured shock velocity profiles exhibit the coalescence times of those shock and contain the first observations of convergence effect (pressure increase with decreasing radius) and the highest shock velocity observed in liquid deuterium (135 km/s). Simulations of these experiments accurately model the shock velocities and timing when a non-local electron transport model is used for heat conduction. These experiments are the basis for tuning campaigns performed on the National Ignition Facility to tune laser pulse shape to achieve the specifications for ignition targets. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  19. Multiple Spherically Converging Shock Waves in Liquid Deuterium

    NASA Astrophysics Data System (ADS)

    Boehly, T. R.; Goncharov, V. N.; Hu, S. X.; Collins, T. J. B.; Marozas, J. A.; Sangster, T. C.; Meyerhofer, D. D.; Barrios, M. A.; Fratanduono, D. E.; Celliers, P. M.; Hicks, D. G.; Collins, G. W.

    2011-10-01

    High-performance ICF target designs use multiple shocks to condition the shell before it is imploded. Accurate timing of these shocks is critical to target performance. We report on experiments on the OMEGA Laser System using directly driven spherical targets filled with liquid deuterium where up to four spherically converging shocks were observed and timed. This technique is the basis for tuning campaigns performed at the National Ignition Facility. The measured shock-velocity profiles exhibit the effects of spherical convergence (pressure increase with decreasing radius) and very high shock velocities (135 km/s). Simulations of these experiments accurately model the shock velocities and timing when a nonlocal electron-transport model is used for heat conduction. The self-emission from these shocks provides the temperature of deuterium shocked to 1 to 5 Mbar. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  20. Neutron Spectroscopy on the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Knauer, J. P.

    2012-10-01

    The performance of cryogenic fuel implosion experiments in progress at the National Ignition Facility (NIF) is measured by an experimental threshold factorfootnotetextM. J. Edwards et al., Phys. Plasmas 18, 051003 (2011). (ITFX) and a generalized Lawson Criterion.footnotetextC. D. Zhou and R. Betti, Phys. Plasmas 15, 102707 (2008); P. Y. Chang et al., Phys. Rev. Lett. 104, 135002 (2010); and R. Betti et al., Phys. Plasmas 17, 058102 (2010). The ITFX metric is determined by the fusion yield and the areal density of an assembled deuterium-tritium (DT) fuel mass. Typical neutron yields from NIF implosions are greater than 10^14 allowing the neutron energy spectrum to be measured with unprecedented precision. A NIF spectrum is composed of neutrons created by fusion (DT, DD, and TT reactions) and neutrons scattered by the dense, cold fuel layer. Neutron scattering is used to determine the areal density of a NIF implosion and is measured along four lines of sight by two neutron time-of-flight detectors, a neutron imaging system, and the magnetic recoil spectrometer. An accurate measurement of the instrument response function for these detectors allows for the routine production of neutron spectra showing DT fuel areal densities up to 1.3 g/cm^2. Spectra over neutron energies of 10 to 17 MeV show areal-density asymmetries of 20% that are inconsistent with simulations. New calibrations and analyses have expended the spectral coverage down to energies less than the deuterium backscatter edge (1.5 MeV for 14 MeV neutrons). These data and analyses are presented along with a compilation of other nuclear diagnostic data that show a larger-than-expected variation in the areal density over the cold fuel mass. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No DE-FC52-08NA28302. In collaboration with NIC.

  1. High Energy Density Studies at the OMEGA laser facility

    NASA Astrophysics Data System (ADS)

    Boehly, Thomas

    2015-06-01

    The primary emphasis of the scientific program at the Laboratory for Laser Energetics is laser-driven inertial confinement fusion. We report on high-energy-density (HED) experiments that use the OMEGA laser to produce multi-megabar shocks in materials of interest to the national fusion effort and the associated HED sciences. We present measurements of the behavior of shocked diamond, in both the single-crystal and ultranano-crystalline forms used as an ablator material in fusion capsules. Using the impedance-matching technique both the Hugoniot and release behaviors are measured with respect to multiple reference materials. The release of shocked diamond into liquid deuterium is also measured. We present the results of sound-speed measurements in shocked quartz which is also used as a reference for sound speed measurements in CH and fused silica. This is done using an unsteady wave analysis that tracks the propagation of small perturbations in shock pressure as they traverse the shocked material from `piston' to shock front. The arrival times of these perturbations, as compared to the same in a reference material, provides the sound speed in the shock material. We also present results of optical and x-ray probing of shock waves in foam targets and solid targets, as well as the release plumes of shock material after shock breakout. The import of these measurements to the fusion program and basic HED science will be discussed and plans for future work presented. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  2. High-Precision Measurements of the Equation of State of Polymers at 100 to 1000 GPa Using Laser-Driven Shock Waves

    NASA Astrophysics Data System (ADS)

    Barrios, M. A.

    2009-11-01

    The equation of state (EOS) of materials at extreme temperatures and pressures is of interest to astrophysics, high-energy-density physics, and inertial confinement fusion (ICF). The high-pressure (>100 GPa) behavior of polymer materials is essential to the understanding of ablator materials for ignition targets. EOS measurements on CHx provide benchmarks on the behavior of polymers under extreme conditions and the effect of stoichiometry (i.e., the C:H ratio) on that behavior. High-power lasers produce shock pressures greater than 100 GPa, and recent advances in diagnostics and analysis have made it possible to perform highly accurate measurements of shock velocity. This improves upon the impedance-matching technique for laser-driven shock experiments, producing ˜1% precision at extreme pressures. The OMEGA laser is used to produce principal (single-shock) Hugoniot EOS measurements on polystyrene (CH), polypropylene (CH2), GDP (C43H56O), and Ge-doped GDP at shock pressures of ˜100 to 1000 GPa. We also present a novel target design that provides double-shock (re-shock) data together with the above data. These data are pertinent to ICF target designs that use multiple shocks to approximate an isentropic compression. Results of the single- and double-shock experiments on these polymers are presented and compared to various EOS models. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302. In collaboration with T.R. Boehly, D.E. Fratanduono, D.D. Meyerhofer (LLE), D.G. Hicks, P.M. Celliers, and G.W. Collins (LLNL).

  3. Hot-Spot Mix in Ignition-Scale Implosions at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Regan, S. P.

    2011-10-01

    Ignition of an inertial confinement fusion target depends on the formation of a central hot spot with sufficient temperature and areal density. Radiative and conductive losses from the hot spot can be enhanced by hydrodynamic instabilities. The concentric spherical layers of current National Ignition Facility ignition targets consist of a plastic ablator surrounding a thin shell of cryogenic thermonuclear fuel (i.e., hydrogen isotopes), with fuel vapor filling the interior volume.The ablator is doped with Ge to minimize preheat of the ablator closest to the DT ice caused by Au M-band emission from the hohlraum x-ray drive. Richtmyer-Meshkov and Rayleigh-Taylor hydrodynamic instabilities seeded by high-mode (50 < λ < 200) ablator-surface perturbations can cause Ge-doped ablator to mix into the interior of the shell at the end of the acceleration phase. As the shell decelerates, it compresses the fuel vapor, forming a hot spot. K-shell line emission from the ionized Ge that has penetrated into the hot spot provides an experimental signature of hot-spot mix. The Ge emission from tritium-hydrogen-deuterium (THD) and DT cryogenic targets and gas-filled plastic-shell capsules, which replace the THD layer with a mass-equivalent CH layer, was examined. The amount of hot-spot mix mass, estimated from the Ge K-shell line brightness using a detailed atomic physics code, is typically below the 100-ng allowance for hot-spot mix.1 Predictions of a simple mix model, based on linear growth of the measured surface-mass modulations, are consistent with the experimental results. The measured dependence of hot-spot mix on the implosion velocity and on the high-mode ablator-surface perturbations will be presented. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302. In collaboration with the National Ignition Campaign Mix Working Group. S. W. Haan et. al., Phys. Plasmas 18, 051001 (2011>).

  4. Enthalpy versus Entropy: the Thermodynamic Origin of Hard Particle Ordering

    NASA Astrophysics Data System (ADS)

    Anthamatten, Mitchell; Chen, Shaw; Ou, Jane; Weinfeld, Jeffrey; Department of Chemical Engineering Team

    The topic of hard particle ordering transitions is important in the development of molecular to mesoscale materials with potential applications in biomedicine, catalysis, optoelectronics, and renewable energy. The first step toward deterministic materials design rests on understanding the thermodynamic nature of ordering transitions involving two phases in equilibrium. We apply classical thermodynamics to show that (i) first-order, hard particle ordering transitions are forbidden at constant volume; and that (ii) hard-particle ordering is driven by a loss in enthalpy through volume reduction that outweighs a concomitant entropy loss upon ordering. The traditional approach considers minimization of Helmholtz energy, at constant volume, whereas the current study exclusively focuses on equilibrium phase transitions and, therefore, targets minimization of Gibbs energy at constant pressure. The Gibbs energy platform offers physically intuitive interpretations consistent with existing computation and experiments. The prevalent idea of entropy-driven ordering at constant V is restricted to transitions from non-equilibrium initial states that have yet to be properly defined for quantification. Laboratory of Laser Energetics, DE-FC52-08NA28302.

  5. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  6. Agreement among 2 x 2 Agreement Indices.

    ERIC Educational Resources Information Center

    Conger, Anthony J.; Ward, David G.

    1984-01-01

    Sixteen measures of reliability for two-category nominal scales are compared. Upon correcting for chance agreement, there are only five distinct indices: Fleiss's modification of A-sub-1, the phi coefficient, Cohen's kappa, and two intraclass coefficients. Recommendations for choosing an agreement index are made based on definitions, magnitude,…

  7. Mining agreements III

    SciTech Connect

    Not Available

    1991-01-01

    This book cover the following: Forms of mining agreements; Preliminary letter agreements; Acquisition of mineral interests involving securities; Partnership tax treatment in mining agreements; Non-tax consequences of partnerships under state law; Protection against joint venturers' liabilities; Joint venture decision making; Mining royalties; Commingling and unitization provisions; Indemnification and insurance provisions; Area of interest provision; Dispute resolution; and Non-participation and default provisions.

  8. Misinterpretations in agreement and agreement attraction.

    PubMed

    Patson, Nikole D; Husband, E Matthew

    2016-05-01

    It has been well established that subject-verb number agreement can be disrupted by local noun phrases that differ in number from the subject head noun phrase. In sentence production, mismatches in the grammatical number of the head and local noun phrases lead to agreement errors on the verb as in: the key to the cabinets are. Similarly, although ungrammaticality typically causes disruption in measures of sentence comprehension, the disruption is reduced when the local noun phrase has a plural feature. Using a forced-choice comprehension question method, we report two experiments that provide evidence that comprehenders were likely to misinterpret the number information on the head noun phrase when morphosyntactic number markings on the local noun phrase and verb did not match the head. These results are consistent with a growing body of research that suggests that comprehenders often arrive at a final interpretation of a sentence that is not faithful to the linguistic input. PMID:25624171

  9. Non-Proliferation Agreements.

    ERIC Educational Resources Information Center

    Swalec, John J.

    1981-01-01

    Discusses five kinds of cooperative agreements established by the College of Lake County (IL): those with other community colleges/technical institutes; the military; business, industry, and organizations; secondary schools; and community and special interest groups. Pays particular attention to two kinds of agreements with other colleges. (CAM)

  10. Cooperative Agreements Study Report.

    ERIC Educational Resources Information Center

    Lawton, R. E.; Magruder, D.

    During the 1983 meeting of the Florida Legislature, action was taken to begin a systematic study of the level of cooperation between the Florida public schools K-12 program and the community and junior colleges. The goals and objectives of the Cooperative Agreements Study were to review and compile a list of the cooperative agreements and identify…

  11. Canadian seismic agreement

    SciTech Connect

    Wetmiller, R.J.; Lyons, J.A.; Shannon, W.E.; Munro, P.S.; Thomas, J.T.; Andrew, M.D.; Lamontagne, M.; Wong, C., Anglin, F.M.; Plouffe, M.; Lapointe, S.P.; Adams, J.; Drysdale, J.A. . Geophysics Div.)

    1990-04-01

    This is the twenty-first progress report under the agreement entitled Canadian Seismic Agreement between the US Nuclear Regulatory Commission (NRC) and the Canadian Commercial Corporation. Activities undertaken by the Geophysics Division of the Geological Survey of Canada (GD/GSC) during the period from July 01, 1988 to June 30, 1989 and supported in part by the NRC agreement are described below under four headings; Eastern Canada Telemetred Network and local network developments, Datalab developments, strong motion network developments and earthquake activity. In this time period eastern Canada experienced its largest earthquake in over 50 years. This earthquake, which has been christened the Saguenay earthquake, has provided a wealth of new data pertinent to earthquake engineering studies in eastern North America and is the subject of many continuing studies, which are presently being carried out at GD and elsewhere. 41 refs., 21 figs., 7 tabs.

  12. FFTF Authorization Agreement

    SciTech Connect

    DAUTEL, W.A.

    2000-09-25

    The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently in the Fast Flux Test Facility (FFTF). Work must be accomplished in a manner that achieves high levels of quality while protecting the environment and the safety and health of workers and the public, and complying with applicable contractual and regulatory requirements. It is the intent of this Agreement to address those items of significant importance in establishing and supporting the FFTF Authorization Envelope, but this Agreement in no way alters the terms and conditions of the Project Hanford Management Contract (PHMC), Contract Number DE-AC06-96RL13200.

  13. Canadian Seismic Agreement

    SciTech Connect

    Wetmiller, R.J.; Lyons, J.A.; Shannon, W.E.; Munro, P.S.; Thomas, J.T.; Andrew, M.D.; Lapointe, S.P.; Lamontagne, M.; Wong, C.; Anglin, F.M.; Adams, J.; Cajka, M.G.; McNeil, W.; Drysdale, J.A. )

    1992-05-01

    This is a progress report of work carried out under the terms of a research agreement entitled the Canadian Seismic Agreement'' between the US Nuclear Regulatory Commission (USNRC), the Canadian Commercial Corporation and the Geophysics Division of the Geological Survey of Canada (GD/GSC) during the period from July 01, 1989 to June 30, 1990. The Canadian Seismic Agreement'' supports generally the operation of various seismograph stations in eastern Canada and the collection and analysis of earthquake data for the purpose of mitigating seismic hazards in eastern Canada and the northeastern US. The specific activities carried out in this one-year period are summarized below under four headings; Eastern Canada Telemetred Network and local network developments, Datalab developments, strong-motion network developments and earthquake activity. During this period the first surface fault unequivocably determined to have accompanied a historic earthquake in eastern North America, occurred in northern Quebec.

  14. FFTF Authorization Agreement

    SciTech Connect

    DAUTEL, W.A.

    2000-02-25

    The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently.

  15. Coefficients for Interrater Agreement.

    ERIC Educational Resources Information Center

    Zegers, Frits E.

    1991-01-01

    The degree of agreement between two raters rating several objects for a single characteristic can be expressed through an association coefficient, such as the Pearson product-moment correlation. How to select an appropriate association coefficient, and the desirable properties and uses of a class of such coefficients--the Euclidean…

  16. Countries renew rescue agreement

    NASA Astrophysics Data System (ADS)

    Bush, Susan M.

    To insure long-term continuity for the international satellite search and rescue system, COSPAS/SARSAT, an intergovernmental agreement binding the four sponsoring nations to cooperate was signed July 1 in Paris. According to Russell Vollmers of the National Oceanic and Atmospheric Administration, the agreement is binding for 15 years, with an automatic extension.The system marked the fifth anniversary of its first rescue last year, when on September 10, 1982, three persons were rescued. Begun in the 1970s by NASA as an experiment, COSPAS/SARSAT (a Russian-English acronym) is now a cooperative project among the United States, Canada, France, and the Soviet Union. Its goal is to reduce the time required to rescue air and maritime distress victims and also to locate victims who otherwise may not be found, thus using the satellite system as a life-saving device.

  17. University-Industry Teaming Agreements.

    ERIC Educational Resources Information Center

    Stombler, Milton P.

    1989-01-01

    The use of preaward agreements between the industry and the university collaborating to seek external funding, particularly from government sources, is examined. The agreements describe the parties' obligations in seeking funding and lay the groundwork for subsequent research agreements. Elements of such agreements are discussed to raise awareness…

  18. Assessment of pharmacogenomic agreement

    PubMed Central

    Safikhani, Zhaleh; El-Hachem, Nehme; Quevedo, Rene; Smirnov, Petr; Goldenberg, Anna; Juul Birkbak, Nicolai; Mason, Christopher; Hatzis, Christos; Shi, Leming; Aerts, Hugo JWL; Quackenbush, John; Haibe-Kains, Benjamin

    2016-01-01

    In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE), were inconsistent. The GDSC and CCLE investigators recently reported that their respective studies exhibit reasonable agreement and yield similar molecular predictors of drug response, seemingly contradicting our previous findings. Reanalyzing the authors’ published methods and results, we found that their analysis failed to account for variability in the genomic data and more importantly compared different drug sensitivity measures from each study, which substantially deviate from our more stringent consistency assessment. Our comparison of the most updated genomic and pharmacological data from the GDSC and CCLE confirms our published findings that the measures of drug response reported by these two groups are not consistent. We believe that a principled approach to assess the reproducibility of drug sensitivity predictors is necessary before envisioning their translation into clinical settings. PMID:27408686

  19. Assessment of pharmacogenomic agreement.

    PubMed

    Safikhani, Zhaleh; El-Hachem, Nehme; Quevedo, Rene; Smirnov, Petr; Goldenberg, Anna; Juul Birkbak, Nicolai; Mason, Christopher; Hatzis, Christos; Shi, Leming; Aerts, Hugo Jwl; Quackenbush, John; Haibe-Kains, Benjamin

    2016-01-01

    In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE), were inconsistent. The GDSC and CCLE investigators recently reported that their respective studies exhibit reasonable agreement and yield similar molecular predictors of drug response, seemingly contradicting our previous findings. Reanalyzing the authors' published methods and results, we found that their analysis failed to account for variability in the genomic data and more importantly compared different drug sensitivity measures from each study, which substantially deviate from our more stringent consistency assessment. Our comparison of the most updated genomic and pharmacological data from the GDSC and CCLE confirms our published findings that the measures of drug response reported by these two groups are not consistent. We believe that a principled approach to assess the reproducibility of drug sensitivity predictors is necessary before envisioning their translation into clinical settings. PMID:27408686

  20. Mining Agreements with Indian Tribes

    ERIC Educational Resources Information Center

    Luebben, Tom

    1976-01-01

    The article discusses aspects of negotiating agreements for exploration, development, and mining of hard minerals on Indian Reservations. The agreements discussed are typical of copper agreements, but the general points under discussion are applicable to most hard minerals except for uranium, coal, and oil which are substantially different.…

  1. Agreement with Subjects in Lubukusu

    ERIC Educational Resources Information Center

    Diercks, Michael J. K.

    2010-01-01

    This dissertation examines three topics in the morphosyntax of Lubukusu (Bantu, Kenya), all of which are concerned with agreement with subjects: locative inversion, complementizer agreement, and alternative agreement effects in subject extraction. Each topic reports novel Lubukusu data which are both typologically interesting and theoretically…

  2. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    PubMed Central

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  3. 77 FR 47880 - U.S.-Trans-Pacific Partnership Free Trade Agreement Including Canada and Mexico: Advice on the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... COMMISSION U.S.-Trans-Pacific Partnership Free Trade Agreement Including Canada and Mexico: Advice on the... instituted investigation nos. TA-131-036 and TA-2104-028, U.S.-Trans-Pacific Partnership Free Trade Agreement... joined the negotiations, known as the Trans-Pacific Partnership (TPP) negotiations, and requested...

  4. On the selectivity of neuronal NOS inhibitors

    PubMed Central

    Pigott, B; Bartus, K; Garthwaite, J

    2013-01-01

    Background and Purpose Isoform-selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl-l-N-5-(1-imino-3-butenyl)-l-ornithine (l-VNIO) and Nω-propyl-l-arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under cell-free conditions, as does N-[(3-aminomethyl)benzyl]acetamidine (1400W), which is primarily an inducible NOS inhibitor. Although used in numerous investigations in vitro and in vivo, there have been surprisingly few tests of the potency and selectivity of these compounds in cells. This study addresses this deficiency and evaluates the activity of new and potentially better pyrrolidine-based compounds. Experimental Approach The inhibitors were evaluated by measuring their effect on NMDA-evoked cGMP accumulation in rodent hippocampal slices, a response dependent on neuronal NOS, and ACh-evoked cGMP synthesis in aortic rings of the same animals, an endothelial NOS-dependent phenomenon. Key Results l-VNIO, NPA and 1400W inhibited responses in both tissues but all showed less than fivefold higher potency in the hippocampus than in the aorta, implying useless selectivity for neuronal over endothelial NOS at the tissue level. In addition, the inhibitors had a 25-fold lower potency in the hippocampus than reported previously, the IC50 values being approximately 1 μM for l-VNIO and NPA, and 150 μM for 1400W. Pyrrolidine-based inhibitors were similarly weak and nonselective. Conclusion and Implications The results suggest that l-VNIO, NPA and 1400W, as well as the newer pyrrolidine-type inhibitors, cannot be used as neuronal NOS inhibitors in cells without stringent verification. The identification of inhibitors with useable selectivity in cells and tissues remains an important goal. PMID:23072468

  5. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  6. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  7. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  8. 75 FR 40837 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ....gov . Agreement No.: 011279-027. Title: Latin America Agreement. Parties: ABC Discussion Agreement; Caribbean Shipowners Association; Central America Discussion Agreement; Compania Libra de Navegacion Uruguay S.A.; Inland Shipping Services Association; Venezuelan Discussion Agreement; West Coast of...

  9. Agreements at the Pharmaceutical/University Interface.

    ERIC Educational Resources Information Center

    Ku, Katherine

    1987-01-01

    Specific agreements that arise at the interface between universities and pharmaceutical companies are described including sponsored research agreements, license agreements, clinical study agreements, material transfer agreements, and patient consent forms with respect to commercialization rights. (Author/MLW)

  10. Skills agreement. Recipe for success.

    PubMed

    Nolan, Alexis

    2007-06-21

    The aims of the national health Sector Skills Agreement need regional and local implementation by stakeholders to become reality. Work in the East of England will produce a first regional skills agreement later this year. The Harlow Project is producing award winning process on recuitment and retention. PMID:17847967

  11. Suspension agreements: The status quota

    SciTech Connect

    1996-01-01

    Since the initial filing of anti-dumping actions uranium imports from the former Soviet Union, a maze of filings, agreements, amendments, bills, measures, and deals have emerged on which only the closest observers remain current. Even with all the actions that have taken place, none of the parties appear content with the status quo and changes to the agreements are ongoing. Given this dynamic state of affairs, a recap of events and a summary of the current agreements is helpful for understanding the concerns of the involved parties and digesting future events.

  12. OPEC agreement and its implications

    SciTech Connect

    Not Available

    1983-01-01

    Following lengthy and intensive negotiations, OPEC recently reached agreement on new prices and production quotas. Although the agreement has been met by general skepticism, Bankers Trust believes that the chances of defending the new marker price are reasonably good. Saudi willingness to reduce oil production and earnings to shield less financially secure OPEC members from the full impact of production cuts provides added and much-needed strength to the organization. If indeed the OPEC agreement proves successful, product prices in the important US market may have already bottomed out.

  13. 76 FR 30360 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ....gov . Agreement No.: 011707-007. Title: Gulf/South America Discussion Agreement. Parties: BBC... Cooperative Working Agreement. Parties: COSCO Terminals America, Inc.; SSA Containers, Inc., and SSA...

  14. Quick Guide: Power Purchase Agreements

    SciTech Connect

    2010-06-25

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  15. Good Agreements Make Good Friends

    PubMed Central

    Han, The Anh; Pereira, Luís Moniz; Santos, Francisco C.; Lenaerts, Tom

    2013-01-01

    When starting a new collaborative endeavor, it pays to establish upfront how strongly your partner commits to the common goal and what compensation can be expected in case the collaboration is violated. Diverse examples in biological and social contexts have demonstrated the pervasiveness of making prior agreements on posterior compensations, suggesting that this behavior could have been shaped by natural selection. Here, we analyze the evolutionary relevance of such a commitment strategy and relate it to the costly punishment strategy, where no prior agreements are made. We show that when the cost of arranging a commitment deal lies within certain limits, substantial levels of cooperation can be achieved. Moreover, these levels are higher than that achieved by simple costly punishment, especially when one insists on sharing the arrangement cost. Not only do we show that good agreements make good friends, agreements based on shared costs result in even better outcomes. PMID:24045873

  16. Application Agreement and Integration Services

    NASA Technical Reports Server (NTRS)

    Driscoll, Kevin R.; Hall, Brendan; Schweiker, Kevin

    2013-01-01

    Application agreement and integration services are required by distributed, fault-tolerant, safety critical systems to assure required performance. An analysis of distributed and hierarchical agreement strategies are developed against the backdrop of observed agreement failures in fielded systems. The documented work was performed under NASA Task Order NNL10AB32T, Validation And Verification of Safety-Critical Integrated Distributed Systems Area 2. This document is intended to satisfy the requirements for deliverable 5.2.11 under Task 4.2.2.3. This report discusses the challenges of maintaining application agreement and integration services. A literature search is presented that documents previous work in the area of replica determinism. Sources of non-deterministic behavior are identified and examples are presented where system level agreement failed to be achieved. We then explore how TTEthernet services can be extended to supply some interesting application agreement frameworks. This document assumes that the reader is familiar with the TTEthernet protocol. The reader is advised to read the TTEthernet protocol standard [1] before reading this document. This document does not re-iterate the content of the standard.

  17. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  18. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  19. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are..., sex, or disability. (d) What is the duration of required agreements? Agreements between FNS and...

  20. 76 FR 31962 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ....gov . Agreement No.: 012128. Title: Southern Africa Agreement A Cooperative Working Agreement. Parties... Atlantic Coast of the United States and ports in the Bahamas and the Republic of South Africa. Agreement...

  1. 77 FR 33459 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... to be exchanged, and delete obsolete language from the agreement. Agreement No.: 012128-001. Title... Agreement and to share the cost of same. Agreement No.: 012173. Title: Hyundai/MOL/APL Asia/Latin...

  2. An evolutionarily ancient NO synthase (NOS) in shrimp.

    PubMed

    Wu, Chun-Hung; Siva, Vinu S; Song, Yen-Ling

    2013-11-01

    Nitric oxide (NO) is a well known essential molecule that is involved in multiple functions such as neuron transduction, cardiac disease, immune responses, etc.; nitric oxide synthase (NOS) is a critical enzyme that catalyzes the synthesis of it. A very few crustacean NOS molecules were biochemically characterized so far. In the present study, we cloned and characterized a NOS cDNA from haemocytes of tiger shrimp (Penaeus monodon) (PmNOS). The full-length of PmNOS cDNA contained 3997 bp, including a 5'UTR of 249 bp, ORF of 3582 bp and a 3'UTR of 166 bp. The putative peptide was 1193 amino acid residues in length, with an estimated molecular weight of 134.7 kDa and pI 6.7. Structurally, PmNOS contained oxygenase and reductase domains at N-terminal and C-terminal, respectively, and connected with a calmodulin binding motif. The deduced amino acid sequence of PmNOS shared 98% identical to the Chinese shrimp (Fenneropenaeus chinensis) NOS. Phylogenetically, PmNOS clustered with invertebrate NOS, but not clustered with iNOS, eNOS or nNOS found in vertebrates. PmNOS mRNA was expressed in many tissues or organs including thoracic and ventral nerves, midgut, gill, eyestalk, haemocytes, subcuticular epithelium and heart, but not found in hepatopancreas, muscle and lymphoid organ. But there was no significant difference in PmNOS mRNA expression after stimulation with LPS either by different concentration or time course or against CpG-ODN 2006. The enzyme activities of rPmNOS or crude homogenates from different tissues were detected, and were shown its highest activity in thoracic and ventral nerves, moderate in midgut and haemocytes but the lowest activity were seen in muscle. The addition of NOS antibody against NADPH binding domain leads to less activity which suggested that NADPH was an essential cofactor for PmNOS catalytic activity. The calcium dependency of PmNOS was ascertained using calmodulin inhibitor, Trifluroperazine. To confirm the population of haemocyte which

  3. Gender agreement and multiple referents

    PubMed Central

    Finocchiaro, Chiara; Mahon, Bradford Z.; Caramazza, Alfonso

    2010-01-01

    We report a new pattern of usage in current, spoken Italian that has implications for both psycholinguistic models of language production and linguistic theories of language change. In Italian, gender agreement is mandatory for both singular and plural nouns. However, when two or more nouns of different grammatical gender appear in a conjoined noun phrase (NP), masculine plural agreement is required. In this study, we combined on-line and off-line methodologies in order to assess the mechanisms involved in gender marking in the context of multiple referents. The results of two pronoun production tasks showed that plural feminine agreement was significantly more difficult than plural masculine agreement. In a separate study using offline judgements of acceptability, we found that agreement violations in Italian are tolerated more readily in the case of feminine conjoined noun phrases (e.g., la mela e la banana ‘the:fem apple:fem and the: fem banana: fem’) than masculine conjoined noun phrases (e.g., il fiore e il libro ‘the:mas flower: mas and the:mas book:mas’). Implications of these results are discussed both at the level of functional architecture within the language production system and at the level of changes in language use.* PMID:21037930

  4. Experience and Grammatical Agreement: Statistical Learning Shapes Number Agreement Production

    ERIC Educational Resources Information Center

    Haskell, Todd R.; Thornton, Robert; MacDonald, Maryellen C.

    2010-01-01

    A robust result in research on the production of grammatical agreement is that speakers are more likely to produce an erroneous verb with phrases such as "the key to the cabinets", with a singular noun followed by a plural one, than with phrases such as "the keys to the cabinet", where a plural noun is followed by a singular. These asymmetries are…

  5. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  6. MRMC analysis of agreement studies

    NASA Astrophysics Data System (ADS)

    Gallas, Brandon D.; Anam, Amrita; Chen, Weijie; Wunderlich, Adam; Zhang, Zhiwei

    2016-03-01

    The purpose of this work is to present and evaluate methods based on U-statistics to compare intra- or inter-reader agreement across different imaging modalities. We apply these methods to multi-reader multi-case (MRMC) studies. We measure reader-averaged agreement and estimate its variance accounting for the variability from readers and cases (an MRMC analysis). In our application, pathologists (readers) evaluate patient tissue mounted on glass slides (cases) in two ways. They evaluate the slides on a microscope (reference modality) and they evaluate digital scans of the slides on a computer display (new modality). In the current work, we consider concordance as the agreement measure, but many of the concepts outlined here apply to other agreement measures. Concordance is the probability that two readers rank two cases in the same order. Concordance can be estimated with a U-statistic and thus it has some nice properties: it is unbiased, asymptotically normal, and its variance is given by an explicit formula. Another property of a U-statistic is that it is symmetric in its inputs; it doesn't matter which reader is listed first or which case is listed first, the result is the same. Using this property and a few tricks while building the U-statistic kernel for concordance, we get a mathematically tractable problem and efficient software. Simulations show that our variance and covariance estimates are unbiased.

  7. Form 6 - gas balancing agreement

    SciTech Connect

    Not Available

    1990-01-01

    In 1988, a special Committee of the Rocky Mountain Mineral Law Foundation undertook a project to draft a model from gas balancing agreement. This project was initiated at the request of a number of Foundation members who felt that a model form gas balancing agreement would facilitate the negotiation of operating agreement, since gas balancing issues had become sticking points in the process. The Committee was composed of attorneys representing a wide cross-section of the oil and gas industry including both major and independent oil companies, production companies with interstate pipeline affiliates, and private practitioners. The Committee attempted to address the more controversial issues in gas balancing with optional provisions in the Form. To facilitate the negotiation process, the number of optional provisions was minimized. This form may be used as an Appendix to the new A.A.P.L. Form 610-1989 Model Form Operating Agreement. This book includes provision of this Form which are: Ownership of gas production; Balancing of production accounts; Cash balancing upon depletion; Deliverability tests; Nominations; Statements; Payment of taxes; Operating expenses; Overproducing allowable; Payment of leasehold burdens; Operator's liability; Successors and assigns; Audits; Arbitration; and Operator's fees.

  8. University of Scranton: Master Agreement.

    ERIC Educational Resources Information Center

    Scranton Univ., PA.

    This document is the collective bargaining agreement between the University of Scranton and its faculty effective September 1, 1975 until August 31, 1976. Its provisions include all full-time faculty members associated with the Reading Clinic and Counseling Center, full-time faculty assigned to the Department of Physical Education, full-time…

  9. Articulation Agreements Ease the Way.

    ERIC Educational Resources Information Center

    Reese, Susan

    2002-01-01

    Articulation agreements between secondary and postsecondary institutions often provide for granting college credit for course work completed at another institution. They have been described as programs designed to create pathways of learning that ease the transition of students from secondary to postsecondary levels. (JOW)

  10. Block Transfer Agreement Evaluation Project

    ERIC Educational Resources Information Center

    Bastedo, Helena

    2010-01-01

    The objective of this project is to evaluate for the British Columbia Council on Admissions and Transfer (BCCAT) the effectiveness of block transfer agreements (BTAs) in the BC Transfer System and recommend steps to be taken to improve their effectiveness. Findings of this study revealed that institutions want to expand block credit transfer;…

  11. Making an Exercise Buddy Agreement

    MedlinePlus

    ... meet your needs. Print out two copies and fill them out together. Then, to make it “official,” both of you should sign them and keep a copy. Review Your Progress Refer back to your agreement at a set time to ...

  12. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

    PubMed

    Kleinschnitz, Christoph; Mencl, Stine; Kleikers, Pamela Wm; Schuhmann, Michael K; G López, Manuela; Casas, Ana I; Sürün, Bilge; Reif, Andreas; Schmidt, Harald Hhw

    2016-09-01

    Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating basic stroke research, we wanted to close that gap by comparing post-synaptic density protein-95 inhibitors with NOS1(-/-) mice and a NOS inhibitor. We confirm the deleterious role of NOS1 in stroke both in vivo and in vitro, but find three pharmacological post-synaptic density protein-95 inhibitors to be therapeutically ineffective. PMID:27354091

  13. SS focused technology: Gateways and NOS's

    NASA Technical Reports Server (NTRS)

    Hartenstein, R.

    1985-01-01

    The extensions and enhancements of the fiber optic data bus technology supported by the Space Station Focused Technology Program are discussed. This includes the operating software for the network called the Network Operating System (NOS); gateways and bridges for multiple network topologies; and very large scale topology implimentations to shrink the size and power of the Bus Interface Unit (BIU) down to more manageable dimensions. CMOS is being investigated for the lower speed (parallel) logic. Gallium arsendide is being studied for the high speed (serial) logic.

  14. Limiting technology by negotiated agreement

    SciTech Connect

    Carnesale, A.

    1983-01-01

    The author concentrates on anti-ballistic missile (ABM) systems as an example of a continuing effort to limit technology by negotiated agreement. He first discusses the ABM treaty of 1972, ratified by both the US and the USSR. Afterwards, he briefly treats each of the following: ballistic missile defense (BMD) dilemmas; nature of the BMD choice; technology; economics; deterrence; nuclear warfighting; relations with allies; arms control; Star Wars; and on limiting technology.

  15. 78 FR 8533 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Agreement. Parties: Crowley Latin America Services, LLC and Dole Ocean Cargo Express, Inc. Filing Party... scope of the agreement, clarifies language in the agreement, and makes technical corrections to...

  16. 77 FR 38288 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... . Agreement No.: 012177. Title: MSC/Maersk Line U.S.-Panama Space Charter Agreement. Parties: Mediterranean... agreement authorizes MSC to charter space to Maersk Line in the trade between ports in Panama and ports...

  17. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  18. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  19. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  20. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  1. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 CFR 33.240 (Intergovernmental agreements). A State may enter into an agreement with a substate... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned...

  2. 78 FR 15951 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... agreement. Agreement No.: 012196. Title: MSC/CSAV Ecuador--North Europe Vessel Sharing Agreement. Parties... on the U.S. East Coast on the one hand, and from ports on the U.S. East Coast to Panama and...

  3. 75 FR 20849 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... geographic scope of the Agreement. Agreement No.: 011830-008. Title: Indamex Cross Space Charter, Sailing and... Limited Slot Charter and Sailing Agreement. Parties: Tropical Shipping & Construction Co., Ltd. and...

  4. 75 FR 11180 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ....gov . Agreement No.: 011730-003. Title: GWF/Dole Space Charter and Sailing Agreement. Parties: Dole... China-US Pacific Coast Two-Loop Space Charter, Sailing and Cooperative Working Agreement. Parties:...

  5. 78 FR 54646 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    .... Agreement No.: 012220. Title: Crowley/Seaboard Space Charter and Sailing Agreement. Parties: Crowley Latin.../America Cruise Ferries, Inc. Space Charter and Sailing Agreement. Parties: Crowley Latin America...

  6. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  7. Specifying PDD-NOS: A Comparison of PDD-NOS, Asperger Syndrome, and Autism

    ERIC Educational Resources Information Center

    Walker, Darlene R.; Thompson, Ann; Zwaigenbaum, Lonnie; Goldberg, Jeremy; Bryson, Susan E.; Mahoney, William J.; Strawbridge, Christina P.; Szatmari, Peter

    2004-01-01

    Objective: To describe the clinical characteristics of children given a diagnosis of pervasive developmental disorder-not otherwise specified (PDD-NOS) by expert clinicians and to compare these to the clinical characteristics of children given a diagnosis of autism and Asperger syndrome (AS). Method: Two hundred sixteen children with autism, 33…

  8. Service Level Agreements in BREIN

    NASA Astrophysics Data System (ADS)

    Koller, Bastian; Frutos, Henar Munoz; Laria, Giuseppe

    With electronic business (eBusiness) becoming ubiquitous, the traditional ways of doing commerce need to be changed or completely replaced to support the end users effectively in performing their business. This includes especially the representation of business relationships with an electronic format to allow for automated processing of the respective parts of e.g. contractual obligations. One prominent representation tool are Service Level Agreements. Conceptually established as paper representation to describe parts of contracts of telecom operators, SLAs have become a research topic in the ICT domain now since several years.

  9. A Scallop Nitric Oxide Synthase (NOS) with Structure Similar to Neuronal NOS and Its Involvement in the Immune Defense

    PubMed Central

    Jiang, Qiufen; Zhou, Zhi; Wang, Leilei; Wang, Lingling; Yue, Feng; Wang, Jingjing; Song, Linsheng

    2013-01-01

    Background Nitric oxide synthase (NOS) is responsible for synthesizing nitric oxide (NO) from L-arginine, and involved in multiple physiological functions. However, its immunological role in mollusc was seldom reported. Methodology In the present study, an NOS (CfNOS) gene was identified from the scallop Chlamys farreri encoding a polypeptide of 1486 amino acids. Its amino acid sequence shared 50.0~54.7, 40.7~47.0 and 42.5~44.5% similarities with vertebrate neuronal (n), endothelial (e) and inducible (i) NOSs, respectively. CfNOS contained PDZ, oxygenase and reductase domains, which resembled those in nNOS. The CfNOS mRNA transcripts expressed in all embryos and larvae after the 2-cell embryo stage, and were detectable in all tested tissues with the highest level in the gonad, and with the immune tissues hepatopancreas and haemocytes included. Moreover, the immunoreactive area of CfNOS distributed over the haemocyte cytoplasm and cell membrane. After LPS, β-glucan and PGN stimulation, the expression level of CfNOS mRNA in haemocytes increased significantly at 3 h (4.0-, 4.8- and 2.7-fold, respectively, P < 0.01), and reached the peak at 12 h (15.3- and 27.6-fold for LPS and β-glucan respectively, P < 0.01) and 24 h (17.3-fold for PGN, P < 0.01). In addition, TNF-α also induced the expression of CfNOS, which started to increase at 1 h (5.2-fold, P < 0.05) and peaked at 6 h (19.9-fold, P < 0.01). The catalytic activity of the native CfNOS protein was 30.3 ± 0.3 U mgprot-1, and it decreased significantly after the addition of the selective inhibitors of nNOS and iNOS (26.9 ± 0.4 and 29.3 ± 0.1 U mgprot-1, respectively, P < 0.01). Conclusions These results suggested that CfNOS, with identical structure with nNOS and similar enzymatic characteristics to nNOS and iNOS, played the immunological role of iNOS to be involved in the scallop immune defense against PAMPs and TNF-α. PMID:23922688

  10. 7 CFR 1948.98 - Grant agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Grant agreements. 1948.98 Section 1948.98 Agriculture... § 1948.98 Grant agreements. The following Grant Agreements are a part of this regulation. (a) Exhibit A of this subpart is a Grant Agreement for Growth Management and Housing Planning Grants for...

  11. 5 CFR 2421.20 - Election agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Election agreement. 2421.20 Section 2421... Election agreement. Election agreement means an agreement under part 2422 of this subchapter signed by all... representation election in an appropriate unit....

  12. 5 CFR 2421.20 - Election agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Election agreement. 2421.20 Section 2421... Election agreement. Election agreement means an agreement under part 2422 of this subchapter signed by all... representation election in an appropriate unit....

  13. 5 CFR 2421.20 - Election agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Election agreement. 2421.20 Section 2421... Election agreement. Election agreement means an agreement under part 2422 of this subchapter signed by all... representation election in an appropriate unit....

  14. 5 CFR 2421.20 - Election agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Election agreement. 2421.20 Section 2421... Election agreement. Election agreement means an agreement under part 2422 of this subchapter signed by all... representation election in an appropriate unit....

  15. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  16. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  17. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  18. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  19. 40 CFR 46.170 - Fellowship agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state...

  20. 77 FR 506 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... . Agreement No.: 011707-008. Title: Gulf/South America Discussion Agreement. Parties: BBC Chartering... restates the agreement. Agreement No.: 012149. Title: MSC/CMA CGM U.S. East Coast-West Coast South America... Coast and the Bahamas, on the one hand, and the West Coast of South America, on the other. By Order...

  1. 77 FR 54911 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    .... Agreement No.: 011426-052. Title: West Coast of South America Discussion Agreement. Parties: Compania... . Agreement No.: 011075-075. Title: Central America Discussion Agreement. Parties: Crowley Latin America... Shipping Company, SA; Seaboard Marine Ltd.; South Pacific Shipping Company, Ltd. (dba Ecuadorian Line);...

  2. 25 CFR 163.71 - Agreement funding.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Agreement funding. 163.71 Section 163.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Cooperative Agreements § 163.71 Agreement funding. In cooperative agreements, the Secretary is authorized to advance...

  3. 25 CFR 163.71 - Agreement funding.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Agreement funding. 163.71 Section 163.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Cooperative Agreements § 163.71 Agreement funding. In cooperative agreements, the Secretary is authorized to advance...

  4. 25 CFR 163.71 - Agreement funding.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Agreement funding. 163.71 Section 163.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Cooperative Agreements § 163.71 Agreement funding. In cooperative agreements, the Secretary is authorized to advance...

  5. 25 CFR 163.71 - Agreement funding.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Agreement funding. 163.71 Section 163.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Cooperative Agreements § 163.71 Agreement funding. In cooperative agreements, the Secretary is authorized to advance...

  6. 25 CFR 163.71 - Agreement funding.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Agreement funding. 163.71 Section 163.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Cooperative Agreements § 163.71 Agreement funding. In cooperative agreements, the Secretary is authorized to advance...

  7. 46 CFR 356.41 - Management agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Management agreements. 356.41 Section 356.41 Shipping..., Management Agreements and Exclusive or Long-Term Contracts § 356.41 Management agreements. (a) An owner or bareboat charterer of a Fishing Industry Vessel may enter into a management agreement with a Non-Citizen...

  8. 46 CFR 356.41 - Management agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Management agreements. 356.41 Section 356.41 Shipping..., Management Agreements and Exclusive or Long-Term Contracts § 356.41 Management agreements. (a) An owner or bareboat charterer of a Fishing Industry Vessel may enter into a management agreement with a Non-Citizen...

  9. 46 CFR 356.41 - Management agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Management agreements. 356.41 Section 356.41 Shipping..., Management Agreements and Exclusive or Long-Term Contracts § 356.41 Management agreements. (a) An owner or bareboat charterer of a Fishing Industry Vessel may enter into a management agreement with a Non-Citizen...

  10. 46 CFR 356.41 - Management agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Management agreements. 356.41 Section 356.41 Shipping..., Management Agreements and Exclusive or Long-Term Contracts § 356.41 Management agreements. (a) An owner or bareboat charterer of a Fishing Industry Vessel may enter into a management agreement with a Non-Citizen...

  11. 46 CFR 356.41 - Management agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Management agreements. 356.41 Section 356.41 Shipping..., Management Agreements and Exclusive or Long-Term Contracts § 356.41 Management agreements. (a) An owner or bareboat charterer of a Fishing Industry Vessel may enter into a management agreement with a Non-Citizen...

  12. 75 FR 19402 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    .... Agreement No.: 012042-002. Title: MOL/ELJSA Slot Exchange Agreement. Parties: Evergreen Line Joint Service.... Title: MOL/APL/HMM Asia/USWC Slot Charter Agreement. Parties: American President Lines, Ltd.; APL Co... sold, and updates party addresses. Agreement No.: 012044-003. Title: MOL/CMA CGM Slot Charter...

  13. 77 FR 61751 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... revises the geographic scope of the Agreement by adding Mexico and deleting Panama. It also revises the... restates the Agreement. Agreement No.: 012184-000. Title: Crowley/Maersk Line Panama-U.S. Space Charter... agreement authorizes Crowley to charter space to Maersk Line in the trade from Panama to the U.S....

  14. 48 CFR 1819.7210 - Agreement terminations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7210 Agreement terminations. (a) Agreements may be terminated for cause or on a voluntary basis by the mentor or the protégé. The procedures for agreement termination are outlined in the mentor-protégé agreement...

  15. 48 CFR 1819.7210 - Agreement terminations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7210 Agreement terminations. (a) Agreements may be terminated for cause or on a voluntary basis by the mentor or the protégé. The procedures for agreement termination are outlined in the mentor-protégé agreement...

  16. 48 CFR 1819.7210 - Agreement terminations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7210 Agreement terminations. (a) Agreements may be terminated for cause or on a voluntary basis by the mentor or the protégé. The procedures for agreement termination are outlined in the mentor-protégé agreement...

  17. 48 CFR 1819.7210 - Agreement terminations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7210 Agreement terminations. (a) Agreements may be terminated for cause or on a voluntary basis by the mentor or the protégé. The procedures for agreement termination are outlined in the mentor-protégé agreement...

  18. 46 CFR 535.201 - Subject agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE OCEAN COMMON CARRIER AND MARINE TERMINAL OPERATOR AGREEMENTS SUBJECT TO THE SHIPPING ACT OF 1984 Scope § 535.201 Subject agreements. (a) Ocean common carrier agreements. This part applies to agreements by or among ocean...

  19. 46 CFR 535.201 - Subject agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE OCEAN COMMON CARRIER AND MARINE TERMINAL OPERATOR AGREEMENTS SUBJECT TO THE SHIPPING ACT OF 1984 Scope § 535.201 Subject agreements. (a) Ocean common carrier agreements. This part applies to agreements by or among ocean...

  20. 46 CFR 535.201 - Subject agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE OCEAN COMMON CARRIER AND MARINE TERMINAL OPERATOR AGREEMENTS SUBJECT TO THE SHIPPING ACT OF 1984 Scope § 535.201 Subject agreements. (a) Ocean common carrier agreements. This part applies to agreements by or among ocean...

  1. 2 CFR 182.620 - Cooperative agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agreement. Cooperative agreement means an award of financial assistance that, consistent with 31 U.S.C. 6305... development agreements as defined in 15 U.S.C. 3710a. ... MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY...

  2. 7 CFR 1948.98 - Grant agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Grant agreements. 1948.98 Section 1948.98 Agriculture... § 1948.98 Grant agreements. The following Grant Agreements are a part of this regulation. (a) Exhibit A of this subpart is a Grant Agreement for Growth Management and Housing Planning Grants for...

  3. 27 CFR 70.485 - Closing agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Closing agreements. 70.485... Relating to Alcohol, Tobacco, Firearms, and Explosives Administrative Remedies § 70.485 Closing agreements... taxable period ending prior or subsequent to the date of such agreement. A closing agreement may...

  4. 27 CFR 70.485 - Closing agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Closing agreements. 70.485... Relating to Alcohol, Tobacco, Firearms, and Explosives Administrative Remedies § 70.485 Closing agreements... taxable period ending prior or subsequent to the date of such agreement. A closing agreement may...

  5. 27 CFR 70.485 - Closing agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Closing agreements. 70.485... Relating to Alcohol, Tobacco, Firearms, and Explosives Administrative Remedies § 70.485 Closing agreements... taxable period ending prior or subsequent to the date of such agreement. A closing agreement may...

  6. 27 CFR 70.485 - Closing agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Closing agreements. 70.485... Relating to Alcohol, Tobacco, Firearms, and Explosives Administrative Remedies § 70.485 Closing agreements... taxable period ending prior or subsequent to the date of such agreement. A closing agreement may...

  7. 27 CFR 70.485 - Closing agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Closing agreements. 70.485... Relating to Alcohol, Tobacco, Firearms, and Explosives Administrative Remedies § 70.485 Closing agreements... taxable period ending prior or subsequent to the date of such agreement. A closing agreement may...

  8. 48 CFR 16.702 - Basic agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Basic agreements may need to be revised before the annual review due to mandatory statutory requirements... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Basic agreements. 16.702... AND CONTRACT TYPES TYPES OF CONTRACTS Agreements 16.702 Basic agreements. (a) Description. A...

  9. 7 CFR 947.111 - Marketing agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Marketing agreement. 947.111 Section 947.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Definitions § 947.111 Marketing agreement. Marketing agreement means Marketing Agreement No. 114, as amended....

  10. 7 CFR 947.111 - Marketing agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Marketing agreement. 947.111 Section 947.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Definitions § 947.111 Marketing agreement. Marketing agreement means Marketing Agreement No. 114, as amended....

  11. 7 CFR 947.111 - Marketing agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing agreement. 947.111 Section 947.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Definitions § 947.111 Marketing agreement. Marketing agreement means Marketing Agreement No. 114, as amended....

  12. 7 CFR 947.111 - Marketing agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Marketing agreement. 947.111 Section 947.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Definitions § 947.111 Marketing agreement. Marketing agreement means Marketing Agreement No. 114, as amended....

  13. 7 CFR 947.111 - Marketing agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing agreement. 947.111 Section 947.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Definitions § 947.111 Marketing agreement. Marketing agreement means Marketing Agreement No. 114, as amended....

  14. The oil and gas joint operating agreement

    SciTech Connect

    Not Available

    1990-01-01

    This book covers the following topics: introduction to the AAPL model form operating agreement; property provisions of the operating agreement; Article 6---the drilling and development article; duties and obligations revisited---who bear what risk of loss; operator's liens; accounting procedure joint operations; insurance; taking gas in kind absent a balancing agreement; RMMLF Form 5 Gas Balancing Agreement; tax partnerships for nontax professionals; alternative agreement forms.

  15. Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts.

    PubMed

    Tenorio-Lopez, Fermin Alejandro; Valle Mondragon, Leonardo Del; Olvera, Gabriela Zarco; Torres Narvaez, Juan Carlos; Pastelin, Gustavo

    2006-11-01

    Viscum album L. aqueous extract, on the Langendorff isolated and perfused heart model, decreases coronary vascular resistance, when compared to control group (36.00 +/- 2.00 vs. 15.80 +/- 1.96 dyn s cm-5). Our data support the fact that this mechanism involves NOS-2 and NOS-3 overexpression (4.65 and 7.89 times over control, respectively), which is correlated with increases in NO (6.24 +/- 2.49 vs. 147.95 +/- 2.79 pmol) and cGMP production (43.94 +/- 2.00 vs. 74.81 +/- 1.96 pmol mg-1 of tissue), compared to control values. Such an effect is antagonized by gadolinium(III) chloride, L-NAME and ODQ. Therefore, coronary vasodilator effect elicited by V. album L. aqueous extract is mediated by the NO/sGC pathway. PMID:17127505

  16. International Agreement on Planetary Protection

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The maintenance of a NASA policy, is consistent with international agreements. The planetary protection policy management in OSS, with Field Center support. The advice from internal and external advisory groups (NRC, NAC/Planetary Protection Task Force). The technology research and standards development in bioload characterization. The technology research and development in bioload reduction/sterilization. This presentation focuses on: forward contamination - research on the potential for Earth life to exist on other bodies, improved strategies for planetary navigation and collision avoidance, and improved procedures for sterile spacecraft assembly, cleaning and/or sterilization; and backward contamination - development of sample transfer and container sealing technologies for Earth return, improvement in sample return landing target assessment and navigation strategy, planning for sample hazard determination requirements and procedures, safety certification, (liaison to NEO Program Office for compositional data on small bodies), facility planning for sample recovery system, quarantine, and long-term curation of 4 returned samples.

  17. Advancing the perceptions of the nature of science (NOS): integrating teaching the NOS in a science content course

    NASA Astrophysics Data System (ADS)

    Aflalo, Ester

    2014-09-01

    Background:Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose:The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores the effects of another approach to teaching that combines teaching the NOS in a course of scientific content. Sample and Programmed description:109 preservice teachers studied the course on 'Cell Biology' or the course, 'Introduction to Life Sciences', whose teaching model differs. In addition to the usual subject matter the courses included activities to understand some aspects of the NOS, reflective discussions, as well as historical descriptions of the scientific discoveries and developments pertaining to the course matter. Design and methods:The study has characteristics of action research The perceptions of the NOS amongst preservice teachers were examined prior to, and following, the course. The perceptions were examined through 35 closed questions and one open question. Results:The findings show that following the course, some of the concepts of NOS changed. Naïve and conservative acuity developed into more current perceptions towards the NOS. Similarly, there was greater internalization of the meaning of the NOS and the significance of its teaching. Conclusions:The findings of this research discuss evidence of the importance of combining the teaching of the NOS in scientific courses in order to advance scientific literacy.

  18. Face and Emotion Recognition in MCDD versus PDD-NOS

    ERIC Educational Resources Information Center

    Herba, Catherine M.; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F.

    2008-01-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial…

  19. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... National Oceanic and Atmospheric Administration RIN 0648-XC703 Endangered Species; File Nos. 17557 and... National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No... Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have applied in due form for...

  20. Multiple Complex Developmental Disorder Delineated from PDD-NOS

    ERIC Educational Resources Information Center

    de Bruin, Esther I.; de Nijs, Pieter F. A.; Verheij, Fop; Hartman, Catharina A.; Ferdinand, Robert F.

    2007-01-01

    The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6-12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity,…

  1. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  2. Magnetic circular dichroism spectroscopic characterization of the NOS-like protein from Geobacillus stearothermophilus (gsNOS).

    PubMed

    Kinloch, Ryan D; Sono, Masanori; Sudhamsu, Jawahar; Crane, Brian R; Dawson, John H

    2010-03-01

    Nitric oxide synthase (NOS) catalyzes the NADPH- and O(2)-dependent oxidation of l-arginine (l-Arg) to nitric oxide (NO) and citrulline via an N(G)-hydroxy-l-arginine (NHA) intermediate. Mammalian NOSs have been studied quite extensively; other eukaryotes and some prokaryotes appear to express NOS-like proteins comparable to the oxygenase domain of mammalian NOSs. In this study, a recombinant NOS-like protein from the thermostable bacterium Geobacillus stearothermophilus (gsNOS) has been characterized using magnetic circular dichroism (MCD) and UV-Vis absorption spectroscopic techniques. Spectral comparisons of ligand complexes (with O(2), NO and CO) of substrate-bound (l-Arg or NHA) gsNOS, including the key oxyferrous complex studied at -50 degrees C in cryogenic mixed solvents, with analogous mammalian NOS complexes indicate overall spectroscopic similarities between gsNOS and mammalian NOSs. However, more detailed spectral comparisons reflect subtle structural differences between gsNOS and mammalian NOSs. This may be due to an incomplete tetrahydrobiopterin (BH(4))-binding site and low BH(4)-binding affinity, which may become even lower in the presence of cryosolvent in gsNOS. Although BH(4)-binding may be altered, gsNOS appears to require the pterin for NO production since formation of the stable ferric-NO product complex was only observed when excess BH(4) (>150muM) over gsNOS was present upon single turnover reaction in which O(2) was bubbled into dithionite-reduced NHA-bound protein solution at -35 degrees C or -50 degrees C. PMID:20110129

  3. Sexual Agreements among Gay Male Couples

    PubMed Central

    Hoff, Colleen H.; Beougher, Sean C.

    2009-01-01

    Many gay male couples make agreements about whether or not to permit sex with outside partners, yet little is known about the development and maintenance of these agreements, their impact on relationships, and whether they are an effective HIV prevention strategy. Using semi-structured, qualitative interviews, 39 gay male couples were asked about their sexual agreements and about other relationship dynamics that might affect their agreements. Analysis revealed a wide range of agreement types, all of which are presented along a continuum rather than as discrete categories. For couples with open agreements, most placed rules or conditions limiting when, where, how often, and with whom outside sex was permitted. Although motivations for having agreements varied, HIV prevention did not rank as a primary factor for any couple. Most couples had congruous agreements; however, a small number reported discrepancies which may increase HIV transmission risk. How couples handled breaks in their agreements also varied, depending on what condition was broken, whether it was disclosed, and the partner's reaction. Additional results include differences in agreement type and motivations for having an agreement based on couple serostatus. Overall, agreements benefited couples by providing boundaries for the relationship, supporting a non-heteronormative identity, and fulfilling the sexual needs of the couple. Future prevention efforts involving gay couples must address the range of agreement types and the meanings couples ascribe to them, in addition to tempering safety messages with the relationship issues that are important to and faced by gay couples. PMID:18686027

  4. Cooperative agreement 926 (SETI Institute)

    NASA Astrophysics Data System (ADS)

    Marshall, John R.

    1996-01-01

    Research activities carried out as part of cooperative agreement 926 are summarized. A portable, field deployable X-ray diffractometer-spectrometer was developed that can analyze rock surfaces and loose granular materials without the need for sample acquisition or preparation. The device was deployed on the Russian Marsokhod rover at the NASA Ames Research Center. Techniques and technological innovations were developed that provide the basis for a new kind of X-ray source. In the area of x-ray analysis techniques, artificial diffraction spectra were created to determine how complex mineral mixtures can be analyzed by diffractometry when only broad fingerprint patterns emerge from the analyses. USML-2 tapes were analyzed. A preliminary, but successful computer code was developed to simulate the behavior of agglomerating granular matter as it may occur in martian dust storms. The model is based on dipole-dipole interactions. In the area of aeolian comminution, using a particle impelling crossbow device , it was possible to elucidate the processes involved in reptation sand transport likely to occur on Mars and Earth. A theoretical model was developed that relates the microscopic cratering mechanisms during saltation-reptation to the megascopic impact processes caused by meteorites. Abstracts of two conference papers as well as five short articles published or submitted for publication are included as attachments.

  5. Monitoring of Biomedical License Agreements

    PubMed Central

    Keller, George H.; Ferguson, Steven M.; Pan, Percy

    2009-01-01

    Because technology licensed from research organizations can play a significant role in drug innovation and the generation of novel biomedical products, licensee performance under such agreements must be effectively monitored. This is necessary so that resultant benefits, including public health improvement, may be returned to the innovator(s) as well as society at large. The tasks that comprise monitoring are varied, but all come under the general heading of ‘enforcement of license provisions’. Since 1996, the license monitoring and enforcement program established by the US National Institutes of Health (NIH) Group has collected about $US17 million in unpaid and underpaid license royalties through formal financial audits and other investigative activities. During the same period, the Office of Technology Transfer (OTT) settled more than 60 cases of suspected patent infringement, generating around 60 new licenses and collected both back and ongoing royalties. As these numbers show, an active and effective monitoring program is an essential part of any technology transfer or biomedical licensing program. PMID:19960074

  6. 22 CFR 124.1 - Manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Manufacturing license agreements and technical... ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.1 Manufacturing... manufacturing license agreements, technical assistance agreements, distribution agreements, or...

  7. 22 CFR 124.1 - Manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Manufacturing license agreements and technical... ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.1 Manufacturing... manufacturing license agreements, technical assistance agreements, distribution agreements, or...

  8. 22 CFR 124.1 - Manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Manufacturing license agreements and technical... ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT, AND OTHER DEFENSE SERVICES § 124.1 Manufacturing... manufacturing license agreements, technical assistance agreements, distribution agreements, or...

  9. 22 CFR 124.1 - Manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Manufacturing license agreements and technical... ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.1 Manufacturing... manufacturing license agreements, technical assistance agreements, distribution agreements, or...

  10. 22 CFR 124.1 - Manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Manufacturing license agreements and technical... ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.1 Manufacturing... manufacturing license agreements, technical assistance agreements, distribution agreements, or...

  11. Vascular nitric oxide: Beyond eNOS.

    PubMed

    Zhao, Yingzi; Vanhoutte, Paul M; Leung, Susan W S

    2015-10-01

    As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis. PMID:26499181

  12. Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts

    PubMed Central

    Roselló-Lletí, Esther; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Carnicer, Ricardo; Lago, Francisca; González-Juanatey, Jose Ramón; Portolés, Manuel; Rivera, Miguel

    2016-01-01

    An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved in the regulation of NOS1 activity, such as protein inhibitor of NOS1 (PIN), calmodulin, heat shock protein 90, and NOS interacting protein. All these molecules have never been analysed in human non-ischemic dilated hearts (DCM). In this study we demonstrated that the upregulation of cardiac NOS1 is not accompanied by increased NOS1 activity in DCM, partly due to the elevated PIN levels and not because of alterations in biopterin biosynthesis. Notably, the PIN concentration was significantly associated with impaired ventricular function, highlighting the importance of this NOS1 activity inhibitor in Ca2+ homeostasis. These results take a central role in the current list of targets for future studies focused on the complex cardiac dysfunction processes through more efficient harnessing of NOS1 signalling. PMID:27481317

  13. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  14. 75 FR 8719 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the... ports of Miami, FL and George Town, Grand Cayman. Agreement No.: 012091. Title: HLAG/HSDG Slot...

  15. 14 CFR 437.35 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Requirements to Obtain an Experimental Permit Operational Safety Documentation § 437.35 Agreements. An applicant must enter into the agreements required by § 437.63, and...

  16. 14 CFR 437.35 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Requirements to Obtain an Experimental Permit Operational Safety Documentation § 437.35 Agreements. An applicant must enter into the agreements required by § 437.63, and...

  17. 37 CFR 42.409 - Settlement agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF COMMERCE TRIAL PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Derivation After Institution of Derivation Proceeding § 42.409 Settlement agreements. An agreement or understanding under 35 U.S.C. 135(e)...

  18. 75 FR 31438 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ... Lines Joint Service Agreement. Filing Party: Tara L. Leiter, Esq.; Blank Rome, LLP; Watergate; 600 New... Service Agreement. Filing Party: Tara L. Leiter, Esq.; Blank Rome, LLP; Watergate; 600 New...

  19. 75 FR 6397 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ....gov . Agreement No.: 011346-019. Title: Israel Trade Conference Agreement. Parties: A.P. Moller-Maersk..., Esq.; Chairman; Israel Trade Conference; 80 Wall Street, Suite 1117; New York, NY 10005-3602....

  20. 48 CFR 1542.1203 - Processing agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT CONTRACT ADMINISTRATION Novation and Change of Name Agreements 1542.1203 Processing agreements. (a... required documentary evidence. (2) Verify the accuracy of the list of contracts through the...

  1. 75 FR 7265 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ....gov . Agreement No.: 011426-047. Title: West Coast of South America Discussion Agreement. Parties: A.P....; Mediterranean Shipping Company, SA; Seaboard Marine Ltd.; South Pacific Shipping Company, Ltd.; and...

  2. 78 FR 30302 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... . Agreement No.: 011707-010. Title: Gulf/South America Discussion Agreement. Parties: Industrial Maritime....; Associate Counsel & Environmental Officer; CMA CGM (America) LLC; 5701 Lake Wright Drive; Norfolk, VA...

  3. 37 CFR 42.409 - Settlement agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF COMMERCE TRIAL PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Derivation After Institution of Derivation Proceeding § 42.409 Settlement agreements. An agreement or understanding under 35 U.S.C. 135(e)...

  4. 76 FR 43686 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    .... Agreement No.: 012133. Title: Mitsui O.S.K. Lines/Kawasaki Kisen Kaisha Space Charter Agreement. Parties: Kawasaki Kisen Kaisha, Ltd. and Mitsui O.S.K. Lines, Ltd. Filing Party: John P. Meade, Esq.;...

  5. 77 FR 24712 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... existing services. Agreement No.: 012165. Title: MOL/APL/HMM Asia/USEC Slot Charter Agreement. Parties... to charter space to APL and HMM on certain vessels MOL operates or on which MOL has space...

  6. 76 FR 63618 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Singapore. Agreement No.: 012138. Title: CSAV/CCNI Venezuela Space Charter Agreement. Parties: Compana Sud... Venezuela. Dated: October 7, 2011. By Order of the Federal Maritime Commission. Karen V. Gregory,...

  7. 42 CFR 460.154 - Enrollment agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... agreement which contains, at a minimum, the following information: (a) Applicant's name, sex, and date of... service provider. (q) A statement that the PACE organization has an agreement with CMS and the...

  8. 75 FR 74732 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-01

    ... after November 24, 2010. Agreement No.: 012111. Title: Hainan PO Shipping Co., Ltd. and TS Lines Ltd. Slot Charter Agreement. Parties: Hainan PO Shipping Co., Ltd. and T.S. Lines Ltd. Filing Party: Neal...

  9. 78 FR 23251 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ..., Vengrow & Textor, LLP; 61 Broadway, Suite 3000, New York, NY 10006-2802 Synopsis: The agreement authorizes...; 61 Broadway, Suite 3000, New York, NY 10006- 2802. Synopsis: The agreement authorizes the parties...

  10. 77 FR 68121 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ..., Sailing and Cooperative Working Agreement. Parties: Priority RoRo Services, LLC and Marine Express, Inc.../Ro Space Charter and Sailing Agreement. Parties: Crowley Latin America Services, LLC and Priority...

  11. 76 FR 12962 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ....gov . Agreement No.: 011885-002. Title: CMA CGM/MSC Reciprocal Space Charter, Sailing and Cooperative... Coast Two-Loop Space Charter, Sailing and Cooperative Working Agreement. Parties: A.P. Moller-Maersk...

  12. 76 FR 61704 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... requirement. Agreement No.: 012136. Title: HSDG/ML/MSC Space Charter Agreement. Parties: Hamburg-Sud, A.P... authorizes Hamburg-Sud and Maersk to charter space to Med Shipping in the trade between U.S. Atlantic...

  13. 76 FR 68187 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ....gov . Agreement No.: 012034-004. Title: Hamburg Sud/Maersk Line Vessel Sharing Agreement. Parties: Hamburg-Sud and A.P. Moeller-Maersk A/S. ] Filing Party: Wayne Rohde, Esq.; Cozen O'Connor; 1627 I...

  14. 78 FR 55697 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... . Agreement No.: 012139-001. Title: OVSA/MSC Space Charter Agreement. Parties: Hamburg-Sud, MSC Mediterranean... Sud North America, Inc.; Hanjin Shipping Company, Ltd.; Hapag-Lloyd (America), Inc; Horizon Lines,...

  15. 77 FR 71192 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ....: 012190. Title: HSDG-GWF Space Charter Agreement. Parties: Hamburg Sud and Great White Fleet Liner..., DC 20006-4007. Synopsis: The agreement authorizes Hamburg Sud to charter space to Great White...

  16. 75 FR 54884 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ...: HLAG/HSDG Trans-Atlantic Space Charter Agreement. Parties: Hamburg Sud and Hapag-Lloyd. Filing Parties...: The agreement authorizes Hapag-Lloyd to charter space to Hamburg Sud in the trade between New York...

  17. 77 FR 74013 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... Agreement. Parties: Hamburg Sud and Compania Chilena De Navegacion Interoceanica, S.A. Filing Party: Wayne R... agreement authorizes Hamburg Sud to charter space to CCNI in the trade between ports in California and...

  18. 78 FR 51757 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Agreement within the GEPS 3 product. Id. at 2. \\1\\ Notice of United States Postal Service of Filing a... Commission first approved the addition of a GEPS negotiated service agreement to the competitive product list... Postal Service therefore requests that the Commission add the Agreement to the GEPS 3 product. Id....

  19. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  20. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  1. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  2. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  3. 48 CFR 519.7010 - Agreement contents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Agreement contents. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7010 Agreement contents. The contents of the Agreement must contain: (a) Names, addresses (including facsimile, e-mail, and...

  4. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  5. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  6. 49 CFR 1325.2 - Credit agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Credit agreements. 1325.2 Section 1325.2... OF TRANSPORTATION (CONTINUED) CARRIER RATES AND SERVICE TERMS EXTENSION OF CREDIT TO CANDIDATES FOR FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.2 Credit agreements. (a) All agreements to extend credit...

  7. 49 CFR 1325.2 - Credit agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Credit agreements. 1325.2 Section 1325.2... OF TRANSPORTATION (CONTINUED) CARRIER RATES AND SERVICE TERMS EXTENSION OF CREDIT TO CANDIDATES FOR FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.2 Credit agreements. (a) All agreements to extend credit...

  8. 49 CFR 1325.2 - Credit agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Credit agreements. 1325.2 Section 1325.2... OF TRANSPORTATION (CONTINUED) CARRIER RATES AND SERVICE TERMS EXTENSION OF CREDIT TO CANDIDATES FOR FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.2 Credit agreements. (a) All agreements to extend credit...

  9. 49 CFR 1325.2 - Credit agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Credit agreements. 1325.2 Section 1325.2... OF TRANSPORTATION (CONTINUED) CARRIER RATES AND SERVICE TERMS EXTENSION OF CREDIT TO CANDIDATES FOR FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.2 Credit agreements. (a) All agreements to extend credit...

  10. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  11. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  12. 49 CFR 1325.2 - Credit agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Credit agreements. 1325.2 Section 1325.2... OF TRANSPORTATION (CONTINUED) CARRIER RATES AND SERVICE TERMS EXTENSION OF CREDIT TO CANDIDATES FOR FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.2 Credit agreements. (a) All agreements to extend credit...

  13. 48 CFR 1819.7209 - Credit agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Credit agreements. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7209 Credit agreements. (a) The credit permits the mentor to include the cost it expends on a mentor-protégé agreement...

  14. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Agreements. 247.4 Section 247.4 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer...

  15. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Agreements. 247.4 Section 247.4 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer...

  16. 76 FR 72408 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  17. 75 FR 366 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreement Filed The Commission hereby gives notice of the filing of the following agreement under the Shipping Act of 1984. Interested parties may submit comments on the agreement to the Secretary, Federal Maritime Commission,...

  18. 77 FR 75162 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  19. 76 FR 17653 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  20. 76 FR 14395 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  1. 46 CFR Sec. 3 - Standby agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Standby agreements. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION B-CONTROL AND UTILIZATION OF PORTS FEDERAL PORT CONTROLLERS Sec. 3 Standby agreements. The Director, NSA, may negotiate the standard form of service agreement, specified...

  2. 46 CFR Sec. 3 - Standby agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Standby agreements. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION B-CONTROL AND UTILIZATION OF PORTS FEDERAL PORT CONTROLLERS Sec. 3 Standby agreements. The Director, NSA, may negotiate the standard form of service agreement, specified...

  3. 77 FR 71001 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    .... Agreement No.: 012188-000. Title: Matson/Kyowa Space Charter Agreement. Parties: Matson Navigation Company, Inc. (``Matson'') and Kyowa Shipping Co., Ltd. (``Kyowa''). Filing Party: Sloan White; Matson; 555...: Matson/Kyowa Space Charter Agreement for Guam and Pacific Islands. Parties: Matson Navigation...

  4. 7 CFR 1776.10 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Grant agreement. 1776.10 Section 1776.10 Agriculture... (CONTINUED) HOUSEHOLD WATER WELL SYSTEM GRANT PROGRAM HWWS Grants § 1776.10 Grant agreement. (a) RUS and the... grant award. RUS will furnish the form of grant agreement. No funds awarded under this part shall...

  5. 7 CFR 1775.13 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Grant agreement. 1775.13 Section 1775.13 Agriculture... (CONTINUED) TECHNICAL ASSISTANCE GRANTS Grant Application Processing § 1775.13 Grant agreement. Applicants selected for funding will complete a grant agreement, RUS Guide 1775-1, which outlines the terms...

  6. 7 CFR 1776.10 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Grant agreement. 1776.10 Section 1776.10 Agriculture... (CONTINUED) HOUSEHOLD WATER WELL SYSTEM GRANT PROGRAM HWWS Grants § 1776.10 Grant agreement. (a) RUS and the... grant award. RUS will furnish the form of grant agreement. No funds awarded under this part shall...

  7. 7 CFR 1775.13 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Grant agreement. 1775.13 Section 1775.13 Agriculture... (CONTINUED) TECHNICAL ASSISTANCE GRANTS Grant Application Processing § 1775.13 Grant agreement. Applicants selected for funding will complete a grant agreement, RUS Guide 1775-1, which outlines the terms...

  8. 29 CFR 102.62 - Election agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Election agreements. 102.62 Section 102.62 Labor... Act § 102.62 Election agreements. (a) Consent election agreements with final regional director determinations of post-election disputes. Where a petition has been duly filed, the employer and any...

  9. 29 CFR 102.62 - Election agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Election agreements. 102.62 Section 102.62 Labor... Act § 102.62 Election agreements. (a) Consent election agreements with final regional director determinations of post-election disputes. Where a petition has been duly filed, the employer and any...

  10. 78 FR 33864 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ...-Product Bilateral Negotiated Service Agreement, May 29, 2013 (Notice); see also Notice of United States... States Postal Service Multi-Product Bilateral Negotiated Service Agreement, Attachment, January 18, 2013... Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission...

  11. 75 FR 61757 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  12. 77 FR 42310 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  13. 33 CFR 385.16 - Design agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Design agreements. 385.16 Section... Processes § 385.16 Design agreements. (a) The Corps of Engineers shall execute a design agreement with each non-Federal sponsor for the projects of the Plan prior to initiation of design activities with...

  14. 75 FR 66098 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  15. 50 CFR 81.6 - Project Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Project Agreement. 81.6 Section 81.6... SPECIES OF FISH, WILDLIFE, AND PLANTS-COOPERATION WITH THE STATES § 81.6 Project Agreement. (a) Subsequent... projects for the conservation of endangered and threatened species. Financial agreements will consist of...

  16. 23 CFR 140.606 - Project agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... projects. 1 The text of FHWA Form PR-2 is found in 23 CFR part 630, subpart C, appendix A. ... 23 Highways 1 2010-04-01 2010-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall...

  17. 23 CFR 633.206 - Project agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Project agreements. 633.206 Section 633.206 Highways... CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.206 Project agreements. (a) Project agreements executed for projects under the Appalachian program shall contain the following paragraphs:...

  18. 29 CFR 29.7 - Apprenticeship agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Apprenticeship agreement. 29.7 Section 29.7 Labor Office of the Secretary of Labor LABOR STANDARDS FOR THE REGISTRATION OF APPRENTICESHIP PROGRAMS § 29.7 Apprenticeship agreement. The apprenticeship agreement must contain, explicitly or by reference: (a) Names and signatures of the contracting parties...

  19. 29 CFR 29.7 - Apprenticeship agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Apprenticeship agreement. 29.7 Section 29.7 Labor Office of the Secretary of Labor LABOR STANDARDS FOR THE REGISTRATION OF APPRENTICESHIP PROGRAMS § 29.7 Apprenticeship agreement. The apprenticeship agreement must contain, explicitly or by reference: (a) Names and signatures of the contracting parties...

  20. 29 CFR 29.7 - Apprenticeship agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Apprenticeship agreement. 29.7 Section 29.7 Labor Office of the Secretary of Labor LABOR STANDARDS FOR THE REGISTRATION OF APPRENTICESHIP PROGRAMS § 29.7 Apprenticeship agreement. The apprenticeship agreement must contain, explicitly or by reference: (a) Names and signatures of the contracting parties...

  1. Method for Measuring Interrater Agreement on Checklists.

    ERIC Educational Resources Information Center

    Sinacore, James M.; Connell, Karen J.; Olthoff, Allan J.; Friedman, Michael H.; Gecht, Maureen R.

    1999-01-01

    Presents a method for measuring interrater agreement on checklists. The technique computes a single agreement score from the concordance of raters' check mark configurations and derives an overall coefficient of agreement called "phi." A medical education study illustrates the phi methodology. (SLD)

  2. 75 FR 39259 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  3. 78 FR 78956 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  4. 78 FR 33840 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    .... East and Gulf Coasts. Agreement No.: 012209. Title: APL/Maersk Line Slot Charter Agreement. Parties: American President Lines, Ltd. and APL Co. Pte, Ltd.; and A.P. Moller-Maersk A/S trading under the name....; Washington, DC 20001. Synopsis: The agreement authorizes APL to charter space to Maersk in the trade...

  5. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time...

  6. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time...

  7. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time...

  8. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time...

  9. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time...

  10. 10 CFR 607.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Cooperative agreement. 607.620 Section 607.620 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.620 Cooperative agreement. Cooperative agreement means an award...

  11. 23 CFR 633.206 - Project agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Project agreements. 633.206 Section 633.206 Highways... CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.206 Project agreements. (a) Project agreements executed for projects under the Appalachian program shall contain the following paragraphs:...

  12. 50 CFR 81.6 - Project Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false Project Agreement. 81.6 Section 81.6... SPECIES OF FISH, WILDLIFE, AND PLANTS-COOPERATION WITH THE STATES § 81.6 Project Agreement. (a) Subsequent... projects for the conservation of endangered and threatened species. Financial agreements will consist of...

  13. 23 CFR 633.206 - Project agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Project agreements. 633.206 Section 633.206 Highways... CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.206 Project agreements. (a) Project agreements executed for projects under the Appalachian program shall contain the following paragraphs:...

  14. 23 CFR 633.206 - Project agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Project agreements. 633.206 Section 633.206 Highways... CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.206 Project agreements. (a) Project agreements executed for projects under the Appalachian program shall contain the following paragraphs:...

  15. 50 CFR 81.6 - Project Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Project Agreement. 81.6 Section 81.6... SPECIES OF FISH, WILDLIFE, AND PLANTS-COOPERATION WITH THE STATES § 81.6 Project Agreement. (a) Subsequent... projects for the conservation of endangered and threatened species. Financial agreements will consist of...

  16. 23 CFR 140.606 - Project agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... projects. 1 The text of FHWA Form PR-2 is found in 23 CFR part 630, subpart C, appendix A. ... 23 Highways 1 2011-04-01 2011-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall...

  17. 23 CFR 140.606 - Project agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... projects. 1 The text of FHWA Form PR-2 is found in 23 CFR part 630, subpart C, appendix A. ... 23 Highways 1 2012-04-01 2012-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall...

  18. 50 CFR 81.6 - Project Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Project Agreement. 81.6 Section 81.6... SPECIES OF FISH, WILDLIFE, AND PLANTS-COOPERATION WITH THE STATES § 81.6 Project Agreement. (a) Subsequent... projects for the conservation of endangered and threatened species. Financial agreements will consist of...

  19. 50 CFR 81.6 - Project Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Project Agreement. 81.6 Section 81.6... SPECIES OF FISH, WILDLIFE, AND PLANTS-COOPERATION WITH THE STATES § 81.6 Project Agreement. (a) Subsequent... projects for the conservation of endangered and threatened species. Financial agreements will consist of...

  20. 23 CFR 140.606 - Project agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... projects. 1 The text of FHWA Form PR-2 is found in 23 CFR part 630, subpart C, appendix A. ... 23 Highways 1 2014-04-01 2014-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall...

  1. 23 CFR 633.206 - Project agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Project agreements. 633.206 Section 633.206 Highways... CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.206 Project agreements. (a) Project agreements executed for projects under the Appalachian program shall contain the following paragraphs:...

  2. 23 CFR 140.606 - Project agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... projects. 1 The text of FHWA Form PR-2 is found in 23 CFR part 630, subpart C, appendix A. ... 23 Highways 1 2013-04-01 2013-04-01 false Project agreements. 140.606 Section 140.606 Highways... Reimbursement for Bond Issue Projects § 140.606 Project agreements. Project Agreements, Form PR-2, shall...

  3. The Pros and Cons of Petroleum Agreements.

    ERIC Educational Resources Information Center

    Lipton, Charles J.

    1980-01-01

    A mineral agreements expert discusses the options open to tribes, from the most standard lease form to arrangements as yet untried by Indian Nations. Discussion covers 18 basic provisions for inclusion in agreements, tax considerations, and basic forms of petroleum agreements (leases, joint ventures, production sharing, and service contracts).…

  4. 47 CFR 27.602 - Lease agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Lease agreements. 27.602 Section 27.602... Lease agreements. Guard Band licensees may enter into spectrum leasing arrangements under part 1... following conditions: (a) The spectrum lease agreement between the licensee and the spectrum lessee...

  5. 78 FR 5440 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  6. 45 CFR 630.620 - Cooperative agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Cooperative agreement. 630.620 Section 630.620 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.620 Cooperative agreement. Cooperative agreement means an award...

  7. 22 CFR 120.23 - Distribution agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse...

  8. 22 CFR 120.23 - Distribution agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse...

  9. 22 CFR 120.23 - Distribution agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse...

  10. 22 CFR 120.23 - Distribution agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse...

  11. 22 CFR 120.23 - Distribution agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse...

  12. 78 FR 76624 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  13. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... entered into a written agreement that the applicant will not engage in school bus operations exclusively for the transportation of students and school personnel in competition with private school bus... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11...

  14. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... entered into a written agreement that the applicant will not engage in school bus operations exclusively for the transportation of students and school personnel in competition with private school bus... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11...

  15. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... entered into a written agreement that the applicant will not engage in school bus operations exclusively for the transportation of students and school personnel in competition with private school bus... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11...

  16. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... entered into a written agreement that the applicant will not engage in school bus operations exclusively for the transportation of students and school personnel in competition with private school bus... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11...

  17. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... entered into a written agreement that the applicant will not engage in school bus operations exclusively for the transportation of students and school personnel in competition with private school bus... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11...

  18. 7 CFR 900.109 - Mediation agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Mediation agreement. 900.109 Section 900.109 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Mediation agreement. An agreement arrived at by mediation shall not become effective until approved by...

  19. 78 FR 10172 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  20. 78 FR 48163 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the Secretary, Federal Maritime Commission,...

  1. 5 CFR 214.204 - Interchange agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EXECUTIVE SERVICE General Provisions § 214.204 Interchange agreements. (a) In accordance with 5 CFR 6.7, OPM... Service (SES) may, pursuant to legislative and regulatory authorities, enter into an agreement providing for the movement of persons between the SES and the other system. The agreement shall define...

  2. 20 CFR 439.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Cooperative agreement. 439.620 Section 439.620 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 439.620 Cooperative agreement. Cooperative agreement means...

  3. 7 CFR 966.111 - Marketing Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Marketing Agreement. 966.111 Section 966.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... and Regulations Definitions § 966.111 Marketing Agreement. Marketing Agreement means...

  4. 7 CFR 917.101 - Marketing agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Marketing agreement. 917.101 Section 917.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... CALIFORNIA Rules and Regulations Definitions § 917.101 Marketing agreement. Marketing agreement...

  5. 7 CFR 946.101 - Marketing agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Marketing agreement. 946.101 Section 946.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... WASHINGTON Rules and Regulations Definitions § 946.101 Marketing agreement. Marketing agreement...

  6. 7 CFR 966.111 - Marketing Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Marketing Agreement. 966.111 Section 966.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... and Regulations Definitions § 966.111 Marketing Agreement. Marketing Agreement means...

  7. 7 CFR 917.101 - Marketing agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing agreement. 917.101 Section 917.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... CALIFORNIA Rules and Regulations Definitions § 917.101 Marketing agreement. Marketing agreement...

  8. 7 CFR 966.111 - Marketing Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Marketing Agreement. 966.111 Section 966.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... and Regulations Definitions § 966.111 Marketing Agreement. Marketing Agreement means...

  9. 7 CFR 917.101 - Marketing agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Marketing agreement. 917.101 Section 917.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... CALIFORNIA Rules and Regulations Definitions § 917.101 Marketing agreement. Marketing agreement...

  10. 7 CFR 966.111 - Marketing Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing Agreement. 966.111 Section 966.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... and Regulations Definitions § 966.111 Marketing Agreement. Marketing Agreement means...

  11. 7 CFR 946.101 - Marketing agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing agreement. 946.101 Section 946.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... WASHINGTON Rules and Regulations Definitions § 946.101 Marketing agreement. Marketing agreement...

  12. 7 CFR 946.101 - Marketing agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Marketing agreement. 946.101 Section 946.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... WASHINGTON Rules and Regulations Definitions § 946.101 Marketing agreement. Marketing agreement...

  13. 7 CFR 917.101 - Marketing agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Marketing agreement. 917.101 Section 917.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... CALIFORNIA Rules and Regulations Definitions § 917.101 Marketing agreement. Marketing agreement...

  14. 7 CFR 946.101 - Marketing agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing agreement. 946.101 Section 946.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... WASHINGTON Rules and Regulations Definitions § 946.101 Marketing agreement. Marketing agreement...

  15. 7 CFR 966.111 - Marketing Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing Agreement. 966.111 Section 966.111 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... and Regulations Definitions § 966.111 Marketing Agreement. Marketing Agreement means...

  16. 7 CFR 917.101 - Marketing agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing agreement. 917.101 Section 917.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... CALIFORNIA Rules and Regulations Definitions § 917.101 Marketing agreement. Marketing agreement...

  17. 7 CFR 946.101 - Marketing agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Marketing agreement. 946.101 Section 946.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... WASHINGTON Rules and Regulations Definitions § 946.101 Marketing agreement. Marketing agreement...

  18. 46 CFR 390.5 - Agreement vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Agreement vessels. 390.5 Section 390.5 Shipping MARITIME....5 Agreement vessels. (a) In general. 46 U.S.C. 53501 states the requirements for eligible, qualified and agreement vessels. The rules in this section further define such terms and state how vessels...

  19. 46 CFR 390.5 - Agreement vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Agreement vessels. 390.5 Section 390.5 Shipping MARITIME....5 Agreement vessels. (a) In general. 46 U.S.C. 53501 states the requirements for eligible, qualified and agreement vessels. The rules in this section further define such terms and state how vessels...

  20. 46 CFR 390.5 - Agreement vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Agreement vessels. 390.5 Section 390.5 Shipping MARITIME....5 Agreement vessels. (a) In general. 46 U.S.C. 53501 states the requirements for eligible, qualified and agreement vessels. The rules in this section further define such terms and state how vessels...

  1. 46 CFR 390.5 - Agreement vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Agreement vessels. 390.5 Section 390.5 Shipping MARITIME....5 Agreement vessels. (a) In general. 46 U.S.C. 53501 states the requirements for eligible, qualified and agreement vessels. The rules in this section further define such terms and state how vessels...

  2. 75 FR 3466 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreement Filed The Commission hereby gives notice of the filing of the following agreement under the Shipping Act of 1984. Interested parties may submit comments on the agreement to the Secretary, Federal Maritime Commission,...

  3. 77 FR 43599 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreement Filed The Commission hereby gives notice of the filing of the following agreement under the Shipping Act of 1984. Interested parties may submit comments on the agreement to the Secretary, Federal Maritime Commission,...

  4. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling

    PubMed Central

    Förstermann, Ulrich; Li, Huige

    2011-01-01

    Nitric oxide (NO) produced by the endothelium is an important protective molecule in the vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all NOS isoforms, functional eNOS transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH), via the flavins flavin adenine dinucleotide and flavin mononucleotide in the carboxy-terminal reductase domain, to the heme in the amino-terminal oxygenase domain. Here, the substrate L-arginine is oxidized to L-citrulline and NO. Cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolaemia or cigarette smoking reduce bioactive NO. These risk factors lead to an enhanced production of reactive oxygen species (ROS) in the vessel wall. NADPH oxidases represent major sources of this ROS and have been found upregulated in the presence of cardiovascular risk factors. NADPH-oxidase-derived superoxide avidly reacts with eNOS-derived NO to form peroxynitrite (ONOO-). The essential NOS cofactor (6R-)5,6,7,8-tetrahydrobiopterin (BH4) is highly sensitive to oxidation by this ONOO-. In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting NOS to a superoxide-producing enzyme. Among conventional drugs, compounds interfering with the renin-angiotensin-aldosterone system and statins can reduce vascular oxidative stress and increase bioactive NO. In recent years, we have identified a number of small molecules that have the potential to prevent eNOS uncoupling and, at the same time, enhance eNOS expression. These include the protein kinase C inhibitor midostaurin, the pentacyclic triterpenoids ursolic acid and betulinic acid, the eNOS enhancing compounds AVE9488 and AVE3085, and the polyphenolic phytoalexin trans-resveratrol. Such compounds enhance NO production from eNOS also under pathophysiological conditions and may thus have therapeutic potential. PMID:21198553

  5. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions About Using History of Science to Teach NOS

    NASA Astrophysics Data System (ADS)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-05-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing biology teachers' understanding of NOS, and their perceptions about using HOS to teach NOS. These teachers ( N = 8), enrolled in a professional development program in Chile are, according to the national curriculum, expected to teach NOS, but have no specific NOS and HOS training. Teachers' views of NOS were assessed using the VNOS-D+ questionnaire at the beginning and at the end of two modules about science instruction and NOS. Both the pre- and the post-test were accompanied by interviews, and in the second session we collected information about teachers' perceptions of which interventions had been more significant in changing their views on NOS. Finally, the teachers also had to prepare a lesson plan for teaching NOS that included HOS. Some of the most important study results were: significant improvements were observed in teachers' understanding of NOS, although they assigned different levels of importance to HOS in these improvements; and although the teachers improved their understanding of NOS, most had difficulties in planning lessons about NOS and articulating historical episodes that incorporated NOS. The relationship between teachers' improved understanding of NOS and their instructional NOS skills is also discussed.

  6. 14 CFR 1274.213 - Distribution of cooperative agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agreements. Copies of cooperative agreements and modifications will be provided to: payment office, technical... provided to the administrative agreement officer and CASI. The cooperative agreement file will contain...

  7. 46 CFR 535.403 - Form of agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... terminal agreements and assessment agreements. (a) Agreements shall be clearly and legibly written. Agreements in a language other than English shall be accompanied by an English translation. (b)...

  8. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury

    PubMed Central

    Filipczak, Piotr T.; Senft, Albert P.; Seagrave, JeanClare; Weber, Waylon; Kuehl, Philip J.; Fredenburgh, Laura E.; McDonald, Jacob D.; Baron, Rebecca M.

    2015-01-01

    Phosgene exposure via an industrial or warfare release produces severe acute lung injury (ALI) with high mortality, characterized by massive pulmonary edema, disruption of epithelial tight junctions, surfactant dysfunction, and oxidative stress. There are no targeted treatments for phosgene-induced ALI. Previous studies demonstrated that nitric oxide synthase 2 (NOS-2) is upregulated in the lungs after phosgene exposure; however, the role of NOS-2 in the pathogenesis of phosgene-induced ALI remains unknown. We previously demonstrated that NOS-2 expression in lung epithelium exacerbates inhaled endotoxin-induced ALI in mice, mediated partially through downregulation of surfactant protein B (SP-B) expression. Therefore, we hypothesized that a selective NOS-2 inhibitor delivered to the lung epithelium by inhalation would mitigate phosgene-induced ALI. Inhaled phosgene produced increases in bronchoalveolar lavage fluid protein, histologic lung injury, and lung NOS-2 expression at 24 h. Administration of the selective NOS-2 inhibitor 1400 W via inhalation, but not via systemic delivery, significantly attenuated phosgene-induced ALI and preserved epithelial barrier integrity. Furthermore, aerosolized 1400 W augmented expression of SP-B and prevented downregulation of tight junction protein zonula occludens 1 (ZO-1), both critical for maintenance of normal lung physiology and barrier integrity. We also demonstrate for the first time that NOS-2-derived nitric oxide downregulates the ZO-1 expression at the transcriptional level in human lung epithelial cells, providing a novel target for ameliorating vascular leak in ALI. Our data demonstrate that lung NOS-2 plays a critical role in the development of phosgene-induced ALI and suggest that aerosolized NOS-2 inhibitors offer a novel therapeutic strategy for its treatment. PMID:25870319

  9. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    PubMed

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p < 0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p < 0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies. PMID:27277302

  10. Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.

    PubMed

    Chan, J Y; Wang, S H; Chan, S H

    2001-01-01

    We investigated the differential contribution of inducible and neuronal nitric oxide synthase (iNOS and nNOS) at the rostral ventrolateral medulla (RVLM) to endotoxemia induced by E. coli lipopolysaccharide (LPS). In Sprague-Dawley rats maintained under propofol anesthesia, i.v. administration of LPS (15, 30, or 45 mg/kg) induced a reduction (phase I), followed by an augmentation (phase II) and a secondary decrease (phase III) in the power density of the vasomotor components (0-0.8 Hz) in systemic arterial pressure (SAP) signals. LPS also induced an immediate hypotension, followed by a rebound increase and a secondary decrease in SAP. In addition, the level of iNOS mRNA exhibited a significant surge that began with phase I endotoxemia, reaching progressively its peak at phase III. Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia. Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. Similar pretreatment with the selective nNOS inhibitor, 7-nitroindazole (1 pmol), on the other hand, discernibly shortened phase II and prolonged phase III endotoxemia, and induced progressive hypotension by antagonizing the rebound increase in SAP. We conclude that the relative prevalence of functional expression and molecular synthesis of iNOS over nNOS in the RVLM may be a crucial determinant for the reduction or loss in power density of the vasomotor components of SAP signals during experimental endotoxemia. PMID:11198360

  11. FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE OF UBER STREET, LOOKING WEST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  12. FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE OF UBER STREET, LOOKING EAST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  13. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  14. Vault Area (original section), east corridor, looking north (Vault Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Vault Area (original section), east corridor, looking north (Vault Nos. 1-9 - Fort McNair, Film Store House, Fort Lesley J. McNair, P Street between Third & Fourth Streets, Southwest, Washington, District of Columbia, DC

  15. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... INFORMATION: On May 31, 2013, notice was published in the Federal Register (78 FR 32622) that requests for a... Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557),...

  16. Interior of Left Powerhouse showing generator Nos. 14. This view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior of Left Powerhouse showing generator Nos. 1-4. This view is from the catwalk at the level of the overhead crane, looking west. - Columbia Basin Project, Grand Coulee Dam Powerplant Complex, Grand Coulee, Grant County, WA

  17. 37. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH SPECIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH SPECIAL HORIZONTAL SAMSON TURBINE (RIVITED CASE) - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  18. 36. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH HORIZONTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH HORIZONTAL SAMSON TURBINES - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  19. 22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Termination of manufacturing license agreements... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade...

  20. 22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Termination of manufacturing license agreements... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade...

  1. 22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Termination of manufacturing license agreements... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade...

  2. 22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Termination of manufacturing license agreements... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade...

  3. 46 CFR 298.38 - Partnership agreements and limited liability company agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Partnership agreements and limited liability company agreements. 298.38 Section 298.38 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION VESSEL FINANCING ASSISTANCE OBLIGATION GUARANTEES Documentation § 298.38 Partnership agreements and limited liability company agreements. Partnership...

  4. 46 CFR 298.38 - Partnership agreements and limited liability company agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Partnership agreements and limited liability company... FINANCING ASSISTANCE OBLIGATION GUARANTEES Documentation § 298.38 Partnership agreements and limited liability company agreements. Partnership and limited liability company agreements must be in form...

  5. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false World Trade Organization Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement...

  6. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false World Trade Organization Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement...

  7. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false World Trade Organization Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement...

  8. eNOS-uncoupling in age-related erectile dysfunction

    PubMed Central

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ‘young’ (4-month-old) and ‘aged’ (19-month-old) rats were treated with a BH4 precursor sepiapterin (10 mg/kg intraperitoneally) or vehicle for 4 days. After 1-day washout, erectile function was assessed in response to electrical stimulation of the cavernous nerve. Endothelial dysfunction (eNOS uncoupling) and oxidative stress (thiobarbituric acid reactive substances, TBARS) were measured by conducting western blot in penes samples. Erectile response was significantly reduced in aged rats, whereas eNOS uncoupling and TBARS production were significantly increased in the aged rat penis compared with young rats. Sepiapterin significantly improved erectile response in aged rats and prevented increase in TBARS production, but did not affect eNOS uncoupling in the penis of aged rats. These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED. PMID:21289638

  9. An agreement coefficient for image comparison

    USGS Publications Warehouse

    Ji, L.; Gallo, K.

    2006-01-01

    Combination of datasets acquired from different sensor systems is necessary to construct a long time-series dataset for remotely sensed land-surface variables. Assessment of the agreement of the data derived from various sources is an important issue in understanding the data continuity through the time-series. Some traditional measures, including correlation coefficient, coefficient of determination, mean absolute error, and root mean square error, are not always optimal for evaluating the data agreement. For this reason, we developed a new agreement coefficient for comparing two different images. The agreement coefficient has the following properties: non-dimensional, bounded, symmetric, and distinguishable between systematic and unsystematic differences. The paper provides examples of agreement analyses for hypothetical data and actual remotely sensed data. The results demonstrate that the agreement coefficient does include the above properties, and therefore is a useful tool for image comparison. ?? 2006 American Society for Photogrammetry and Remote Sensing.

  10. 76 FR 64944 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ...: Hamburg-Sud (``HSDG''); Alianca Navegacao e Logistica Ltda. e CIA (``Alianca''); Compania Sud Americana de...-010. Title: Maritime Credit Agreement. Parties: Alianca Navegacao e Logistica Ltda. & Cia.;...

  11. 7 CFR 3431.18 - Service agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE VETERINARY MEDICINE LOAN REPAYMENT PROGRAM Administration of the Veterinary Medicine Loan Repayment Program § 3431.18 Service agreement. (a) The...

  12. 50 CFR 81.3 - Cooperative Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED... Project Agreement can be approved for endangered or threatened species projects. A cooperative...

  13. Muscular nitric oxide synthase (muNOS) and utrophin.

    PubMed

    Chaubourt, Emmanuel; Voisin, Vincent; Fossier, Philippe; Baux, Gérard; Israël, Maurice; De La Porte, Sabine

    2002-01-01

    Duchenne muscular dystrophy (DMD), the severe X-linked recessive disorder which results in progressive muscle degeneration, is due to a lack of dystrophin, a membrane cytoskeletal protein. Three types of treatment are envisaged: pharmacological (glucocorticoid), myoblast transplantation, and gene therapy. An alternative to the pharmacological approach is to compensate for dystrophin loss by the upregulation of another cytoskeletal protein, utrophin. Utrophin and dystrophin are part of a complex of proteins and glycoproteins, which links the basal lamina to the cytoskeleton, thus ensuring the stability of the muscle membrane. One protein of the complex, syntrophin, is associated with a muscular isoform of the neuronal nitric oxide synthase (nNOS). We have demonstrated an overexpression of utrophin, visualised by immunofluorescence and quantified by Western blotting, in normal myotubes and in mdx (the animal model of DMD) myotubes, as in normal (C57) and mdx mice, both treated with nitric oxide (NO) donor or L-arginine, the NOS substrate. There is evidence that utrophin may be capable of performing the same cellular functions as dystrophin and may functionally compensate for its lack. Thus, we propose to use NO donors, as palliative treatment of Duchenne and Becker muscular dystrophies, pending, or in combination with, gene and/or cellular therapy. Discussion has focussed on the various isoforms of NOS that could be implicated in the regeneration process. Dystrophic and healthy muscles respond to treatment, suggesting that although NOS is delocalised in the cytoplasm in the case of DMD, it conserves substantial activity. eNOS present in mitochondria and iNOS present in cytoplasm and the neuromuscular junction could also be activated. Lastly, production of NO by endothelial NOS of the capillaries would also be beneficial through increased supply of metabolites and oxygen to the muscles. PMID:11755782

  14. 76 FR 2114 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Notice of Agreements Filed The Commission hereby gives notice of the filing of the following agreements... Vapores, S.A.; CP Ships (U.K.) Ltd.; Crowley Liner Services, Inc.; CP Ships USA, LLC; Hanjin Shipping...

  15. 48 CFR 1819.7206 - Agreement contents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Agreement contents. 1819.7206 Section 1819.7206 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... contents. Each mentor-protégé agreement will contain the following elements: (a) The name, address,...

  16. 48 CFR 1819.7206 - Agreement contents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Agreement contents. 1819.7206 Section 1819.7206 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... contents. Each mentor-protégé agreement will contain the following elements: (a) The name, address,...

  17. 48 CFR 1819.7206 - Agreement contents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Agreement contents. 1819.7206 Section 1819.7206 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... contents. Each mentor-protégé agreement will contain the following elements: (a) The name, address,...

  18. 48 CFR 1819.7206 - Agreement contents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Agreement contents. 1819.7206 Section 1819.7206 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... contents. Each mentor-protégé agreement will contain the following elements: (a) The name, address,...

  19. 48 CFR 1819.7206 - Agreement contents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Agreement contents. 1819.7206 Section 1819.7206 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... contents. Each mentor-protégé agreement will contain the following elements: (a) The name, address,...

  20. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  1. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  2. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each...

  3. 12 CFR 1807.900 - Assistance agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Assistance agreement. 1807.900 Section 1807.900 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Terms and Conditions of Assistance § 1807.900 Assistance agreement. (a) Each Applicant...

  4. 26 CFR 601.802 - Cooperative agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STATEMENT OF PROCEDURAL RULES Tax Counseling for the Elderly § 601.802 Cooperative agreements. (a) General. Tax Counseling for the Elderly programs will be administered by sponsor organizations under... agreements. If appropriations to implement the Tax Counseling for the Elderly program are received at a...

  5. 26 CFR 601.802 - Cooperative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STATEMENT OF PROCEDURAL RULES Tax Counseling for the Elderly § 601.802 Cooperative agreements. (a) General. Tax Counseling for the Elderly programs will be administered by sponsor organizations under... agreements. If appropriations to implement the Tax Counseling for the Elderly program are received at a...

  6. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a...

  7. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  8. 31 CFR 540.305 - HEU Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Government of the United States of America and the Government of the Russian Federation Concerning...'s Executive Agent under the Agreement Between the United States and the Russian Federation...; (b) Agreement Between the United States Department of Energy and the Ministry of the...

  9. 75 FR 76729 - Market Access Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... Federal Register on October 20, 2010 (75 FR 64727). In the supplementary information we provided when we... Market Access Agreement AGENCY: Farm Credit Administration. ACTION: Notice of approval of the draft amendment to the amended and restated market access agreement. SUMMARY: The Farm Credit Administration...

  10. 75 FR 150 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ... President Lines, Ltd. and APL Co. PTE Ltd.; (operating as a single carrier); China Shipping Container Lines (Hong Kong) Company Limited and China Shipping Container Lines Company Limited (operating as a single... pollution. Agreement No.: 012008-004. Title: The 360 Quality Association Agreement. Parties: NYKCool AB...

  11. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a...

  12. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  13. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  14. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  15. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  16. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a...

  17. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  18. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  19. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  20. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... REGULATORY PROGRAMS FOR NON-FEDERAL AND NON-INDIAN LANDS GRANTS FOR PROGRAM DEVELOPMENT AND ADMINISTRATION AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves...

  1. 7 CFR 1424.5 - Agreement process.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Agreement process. 1424.5 Section 1424.5 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.5 Agreement process. (a)...

  2. 76 FR 11473 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ....gov . Agreement No.: 011346-022. Title: Israel Carrier Association. Parties: A.P. Moller-Maersk A/S... Party: Howard A. Levy, Esq.; Chairman; Israel Trade Conference; 80 Wall Street, Suite 1117; New York, NY... service contract with Israel's Ministry of Defense, changes the Agreement's name from Israel...

  3. 32 CFR 855.23 - Other agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855.23 Other agreements. (a) Temporary use of Air Force runways occasionally is needed for extended periods when a...

  4. 32 CFR 855.23 - Other agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855.23 Other agreements. (a) Temporary use of Air Force runways occasionally is needed for extended periods when a...

  5. 32 CFR 855.23 - Other agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855.23 Other agreements. (a) Temporary use of Air Force runways occasionally is needed for extended periods when a...

  6. 32 CFR 855.23 - Other agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855.23 Other agreements. (a) Temporary use of Air Force runways occasionally is needed for extended periods when a...

  7. 32 CFR 855.23 - Other agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855.23 Other agreements. (a) Temporary use of Air Force runways occasionally is needed for extended periods when a...

  8. 40 CFR 2.215 - Confidentiality agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Confidentiality agreements. 2.215 Section 2.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION Confidentiality of Business Information § 2.215 Confidentiality agreements. (a) No EPA officer,...

  9. 48 CFR 31.109 - Advance agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Statistical sampling methods (see 31.201-6(c)(4). ... contractors should seek advance agreement on the treatment of special or unusual costs and on statistical sampling methodologies at 31.201-6(c). However, an advance agreement is not an absolute requirement and...

  10. 48 CFR 31.109 - Advance agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Statistical sampling methods (see 31.201-6(c)(4). ... contractors should seek advance agreement on the treatment of special or unusual costs and on statistical sampling methodologies at 31.201-6(c). However, an advance agreement is not an absolute requirement and...

  11. 48 CFR 31.109 - Advance agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Statistical sampling methods (see 31.201-6(c)(4). ... contractors should seek advance agreement on the treatment of special or unusual costs and on statistical sampling methodologies at 31.201-6(c). However, an advance agreement is not an absolute requirement and...

  12. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  13. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  14. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  15. 24 CFR 583.400 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Grant agreement. 583.400 Section 583.400 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES SUPPORTIVE HOUSING PROGRAM Administration § 583.400 Grant agreement....

  16. 5 CFR 370.105 - Written agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Written agreements. 370.105 Section 370.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS INFORMATION TECHNOLOGY EXCHANGE PROGRAM § 370.105 Written agreements. Before the detail begins, the agency and...

  17. Your EHR license agreement: critical issues.

    PubMed

    Shay, Daniel F

    2014-01-01

    This article discusses several key provisions and concepts in software license agreements for electronic health records. It offers insight into what physician practices can expect to find in their license agreements, as well as practical advice on beneficial provisions. The article examines contractual language relating to term and termination, technical specifications and support, and compliance with governmental programs. PMID:25241452

  18. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  19. Agreement of Personality Profiles across Observers.

    ERIC Educational Resources Information Center

    McCrae, Robert R.

    1993-01-01

    To assess cross-observer agreement on personality profiles, an Index of Profile Agreement and an associated coefficient are proposed that take into account both the difference between the ratings and the extremes of their mean. Data from the Revised NEO Personality Inventory for 250 peer ratings/self-reports and 68 spouse ratings/self-reports…

  20. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Administrative agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete...

  1. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 20 2014-04-01 2014-04-01 false Closing agreements. 601.202 Section 601.202 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INTERNAL REVENUE PRACTICE STATEMENT OF PROCEDURAL RULES Rulings and Other Specific Matters § 601.202 Closing agreements. (a) General. (1) Under section 7121 of the...

  2. 76 FR 74060 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... geographic scope to include Sri Lanka, the United Arab Emirates, Indonesia, Korea, and Australia. Agreement... Agriculture Investment Export, Inc. Filing Party: Wade S. Hooker, Esquire, 21 Central Park W.; New York, NY 10024. Synopsis: The agreement authorizes Great White Fleet to charter space to Agriculture...

  3. 77 FR 10743 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... Sharing Agreement. Parties: MSC Mediterranean Shipping Company, S.A. and Zim Integrated Shipping Services... trade between countries in the Mediterranean Sea and the Atlantic Coast of the United States and Canada....: 201160-003. Title: Marine Terminal Lease and Operating Agreement Between Broward County and...

  4. 75 FR 67749 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ....: 011435-014. Title: APL/HLAG Space Charter Agreement. Parties: American President Lines, Ltd.; APL Co. Pte...., Suite 1100, Washington, DC 20006. Synopsis: The amendment updates the corporate address for APL...: APL/Maersk Line Reciprocal Space Charter Agreement. Parties: American President Lines, Ltd.; APL...

  5. 78 FR 63474 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ..., on the other hand. Agreement No.: 012154-001. Title: APL/Hamburg S d Space Charter Agreement. Parties: APL Co. Pte, Ltd. and American President Lines, Ltd. (acting as one party); and Hamburg S d KG Filing.... Synopsis: The amendment authorizes APL to provide Hamburg S d with space on alternative services...

  6. 76 FR 7209 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... Lines, Ltd.; APL Co. PTE Ltd.; A.P. Moller-Maersk A/S; and Hapag-Lloyd USA, LLC. Filing Party: Wayne... amendment would add Hapag-Lloyd AG as a party to the agreement and update APL's address. Agreement...

  7. 77 FR 58592 - Modified Norway Post Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ...The Commission is noticing a recently-filed Postal Service request to include a modified Norway Post Agreement within an existing competitive product. The modification includes an 18-month extension of the original agreement's term. This notice addresses procedural aspects of the...

  8. Cooperative monitoring of regional security agreements

    SciTech Connect

    Pregenzer, A.L.; Vannoni, M.; Biringer, K.L.

    1996-11-01

    This paper argues that cooperative monitoring plays a critical role in the implementation of regional security agreements and confidence building measures. A framework for developing cooperative monitoring options is proposed and several possibilities for relating bilateral and regional monitoring systems to international monitoring systems are discussed. Three bilateral or regional agreements are analyzed briefly to illustrate different possibilities. These examples illustrate that the relationship of regional or bilateral arms control or security agreements to international agreements depends on a number of factors: the overlap of provisions between regional and international agreements; the degree of interest in a regional agreement among the international community; efficiency in implementing the agreement; and numerous political considerations. Given the importance of regional security to the international community, regions should be encouraged to develop their own infrastructure for implementing regional arms control and other security agreements. A regional infrastructure need not preclude participation in an international regime. On the contrary, establishing regional institutions for arms control and nonproliferation could result in more proactive participation of regional parties in developing solutions for regional and international problems, thereby strengthening existing and future international regimes. Possible first steps for strengthening regional infrastructures are identified and potential technical requirements are discussed.

  9. 34 CFR 675.48 - Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Agreement. 675.48 Section 675.48 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.48 Agreement. To...

  10. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  11. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  12. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  13. 23 CFR 710.307 - Project agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... acquisitions, including hardship acquisition and protective buying (see 23 CFR 710.503). The STD must prepare a project agreement in accordance with 23 CFR part 630, subpart C. The agreement shall be based on an..., donations, or other contributions applied to the project provided conditions in 23 U.S.C. 323 and 23 CFR...

  14. 22 CFR 1509.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cooperative agreement. 1509.620 Section 1509.620 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE... award. The term does not include cooperative research and development agreements as defined in 15...

  15. 22 CFR 1008.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cooperative agreement. 1008.620 Section 1008.620 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... term does not include cooperative research and development agreements as defined in 15 U.S.C. 3710a....

  16. 36 CFR 222.28 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 222.28 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.28 Agreements. The Chief, Forest Service, may enter into agreements as he deems necessary to further the protection, management, and control of wild...

  17. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false International agreements. 24.5 Section 24... WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.5 International agreements. (a) International conventions... shall be to recommend that the United States negotiate and accede to only those international...

  18. 47 CFR 73.1650 - International agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false International agreements. 73.1650 Section 73... BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1650 International agreements. (a) The... international obligations and undertakings of the United States. Accordingly, all provisions in this part 73...

  19. 47 CFR 73.1650 - International agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false International agreements. 73.1650 Section 73... BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1650 International agreements. (a) The... international obligations and undertakings of the United States. Accordingly, all provisions in this part 73...

  20. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true International agreements. 24.5 Section 24.5... WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.5 International agreements. (a) International conventions... shall be to recommend that the United States negotiate and accede to only those international...

  1. 47 CFR 73.1650 - International agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false International agreements. 73.1650 Section 73... BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1650 International agreements. (a) The... international obligations and undertakings of the United States. Accordingly, all provisions in this part 73...

  2. 47 CFR 73.1650 - International agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false International agreements. 73.1650 Section 73... BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1650 International agreements. (a) The... international obligations and undertakings of the United States. Accordingly, all provisions in this part 73...

  3. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false International agreements. 24.5 Section 24... WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.5 International agreements. (a) International conventions... shall be to recommend that the United States negotiate and accede to only those international...

  4. 47 CFR 73.1650 - International agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false International agreements. 73.1650 Section 73... BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1650 International agreements. (a) The... international obligations and undertakings of the United States. Accordingly, all provisions in this part 73...

  5. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false International agreements. 24.5 Section 24... WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.5 International agreements. (a) International conventions... shall be to recommend that the United States negotiate and accede to only those international...

  6. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false International agreements. 24.5 Section 24... WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.5 International agreements. (a) International conventions... shall be to recommend that the United States negotiate and accede to only those international...

  7. 7 CFR 1424.5 - Agreement process.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Agreement process. 1424.5 Section 1424.5 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.5 Agreement process. (a)...

  8. 7 CFR 1424.5 - Agreement process.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Agreement process. 1424.5 Section 1424.5 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.5 Agreement process. (a)...

  9. 7 CFR 1424.5 - Agreement process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Agreement process. 1424.5 Section 1424.5 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.5 Agreement process. (a)...

  10. 7 CFR 1424.5 - Agreement process.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Agreement process. 1424.5 Section 1424.5 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.5 Agreement process. (a)...

  11. Agreement between Two Independent Groups of Raters

    ERIC Educational Resources Information Center

    Vanbelle, Sophie; Albert, Adelin

    2009-01-01

    We propose a coefficient of agreement to assess the degree of concordance between two independent groups of raters classifying items on a nominal scale. This coefficient, defined on a population-based model, extends the classical Cohen's kappa coefficient for quantifying agreement between two raters. Weighted and intraclass versions of the…

  12. 7 CFR 1599.5 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Agreements. 1599.5 Section 1599.5 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF AGRICULTURE McGOVERN-DOLE INTERNATIONAL FOOD FOR EDUCATION AND CHILD NUTRITION PROGRAM § 1599.5 Agreements. (a) After FAS approves an applicant's...

  13. 14 CFR 142.33 - Training agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training agreements. 142.33 Section 142.33... OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.33 Training agreements. A pilot school certificated under part 141 of this chapter may provide training, testing, and checking for a training...

  14. 14 CFR 141.26 - Training agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training agreements. 141.26 Section 141.26... OTHER CERTIFICATED AGENCIES PILOT SCHOOLS General § 141.26 Training agreements. A training center certificated under part 142 of this chapter may provide the training, testing, and checking for pilot...

  15. 39 CFR 963.12 - Settlement agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Settlement agreements. 963.12 Section 963.12 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO VIOLATIONS OF THE PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.12 Settlement agreements....

  16. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Administrative agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete...

  17. 36 CFR 254.14 - Exchange agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required congressional oversight; (6) In the event of an appeal under 36 CFR part 215 or 36 CFR part 251... agreement. (c) In the event of a failure to perform or to comply with the terms of an exchange agreement..., title searches, title curative actions, cultural resource surveys and mitigation, hazardous...

  18. 23 CFR 635.115 - Agreement estimate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... submitted by the STD for each force account project (see 23 CFR part 635, subpart B) when the plans and... 23 Highways 1 2010-04-01 2010-04-01 false Agreement estimate. 635.115 Section 635.115 Highways... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.115 Agreement estimate. (a) Following the award...

  19. Tense and Agreement in German Agrammatism

    ERIC Educational Resources Information Center

    Wenzlaff, Michaela; Clahsen, Harald

    2004-01-01

    This study presents results from sentence-completion and grammaticality-judgment tasks with 7 German-speaking agrammatic aphasics and 7 age-matched control subjects examining tense and subject-verb agreement marking. For both experimental tasks, we found that the aphasics achieved high correctness scores for agreement, while tense marking was…

  20. 32 CFR 644.137 - Maneuver agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Maneuver agreements. 644.137 Section 644.137 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Acquisition by Leasing § 644.137 Maneuver agreements. Joint...

  1. 32 CFR 644.137 - Maneuver agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Maneuver agreements. 644.137 Section 644.137 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Acquisition by Leasing § 644.137 Maneuver agreements. Joint...

  2. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 20 2013-04-01 2013-04-01 false Closing agreements. 601.202 Section 601.202 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INTERNAL REVENUE PRACTICE STATEMENT OF PROCEDURAL RULES Rulings and Other Specific Matters § 601.202 Closing agreements. (a) General. (1) Under section 7121 of the...

  3. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  4. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  5. 26 CFR 601.202 - Closing agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Approval. (1) Closing agreements relating to alcohol, tobacco, and firearms, taxes in respect of any... approved by the Director, Bureau of Alcohol, Tobacco, and Firearms. (2) Closing agreements relating to... or accounts are not includable in gross income until maturity or termination, whichever...

  6. Noncompetition Agreements: How Informed Are Counselors?

    ERIC Educational Resources Information Center

    Daniels, M. Harry; White, Lyle J.; Wyatt, Tracey

    2003-01-01

    Assesses American Mental Health Counselor Association members' knowledge of legal bases for noncompetition contracts and their agreement with the legal opinions and also assesses the degree of similarity and dissimilarity between members' knowledge of and agreement with the legal opinions. Results showed that counselors are better prepared to look…

  7. Agreement Attraction in Comprehension: Representations and Processes

    ERIC Educational Resources Information Center

    Wagers, Matthew W.; Lau, Ellen F.; Phillips, Colin

    2009-01-01

    Much work has demonstrated so-called attraction errors in the production of subject-verb agreement (e.g., "The key to the cabinets are on the table", [Bock, J. K., & Miller, C. A. (1991). "Broken agreement." "Cognitive Psychology, 23", 45-93]), in which a verb erroneously agrees with an intervening noun. Six self-paced reading experiments examined…

  8. 47 CFR 27.602 - Lease agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Lease agreements. Guard Band licensees may enter into spectrum leasing arrangements under part 1, subpart X of this chapter regarding the use of their licensed spectrum by spectrum lessees, subject to the following conditions: (a) The spectrum lease agreement between the licensee and the spectrum lessee...

  9. 47 CFR 27.602 - Lease agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Lease agreements. Guard Band licensees may enter into spectrum leasing arrangements under part 1, subpart X of this chapter regarding the use of their licensed spectrum by spectrum lessees, subject to the following conditions: (a) The spectrum lease agreement between the licensee and the spectrum lessee...

  10. 47 CFR 27.602 - Lease agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Lease agreements. Guard Band licensees may enter into spectrum leasing arrangements under part 1, subpart X of this chapter regarding the use of their licensed spectrum by spectrum lessees, subject to the following conditions: (a) The spectrum lease agreement between the licensee and the spectrum lessee...

  11. 47 CFR 27.602 - Lease agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Lease agreements. Guard Band licensees may enter into spectrum leasing arrangements under part 1, subpart X of this chapter regarding the use of their licensed spectrum by spectrum lessees, subject to the following conditions: (a) The spectrum lease agreement between the licensee and the spectrum lessee...

  12. 34 CFR 675.48 - Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false Agreement. 675.48 Section 675.48 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.48 Agreement. To...

  13. 34 CFR 675.48 - Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false Agreement. 675.48 Section 675.48 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.48 Agreement. To...

  14. 34 CFR 675.48 - Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false Agreement. 675.48 Section 675.48 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.48 Agreement. To...

  15. 34 CFR 675.48 - Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Agreement. 675.48 Section 675.48 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Work-Colleges Program § 675.48 Agreement. To participate in the Work-Colleges program, an...

  16. [Innovative medicines and market access agreements].

    PubMed

    Toumi, M; Zard, J; Duvillard, R; Jommi, C

    2013-09-01

    Market Access Agreements (MAA) for drugs have emerged in response to the need to control health expenditures, as well as to the uncertainty about the true benefit of a drug. It is possible to group MAA in two types of agreements: financial agreements and outcome-based agreements. MAA is a growing trend and is shifting towards conditional access. However, the willingness to use these contracts and their implementation differ across countries, and some are still resistant to put them in place. The MAA challenges to overcome encompass the complexity of the schemes, the administrative burden and the difficulty of evaluating MAA. It is likely that these agreements might experience further evolution in the future to become a faster pathway for therapeutic innovations, at a fair price. PMID:24075701

  17. Cooperative monitoring of regional security agreements

    SciTech Connect

    Pregenzer, A.L.; Vannoni, M.; Biringer, K.L.

    1995-08-01

    This paper argues that cooperative monitoring plays a critical role in the implementation of regional security agreements and confidence building measures. A framework for developing cooperative monitoring options is proposed and several possibilities for relating bilateral and regional monitoring systems to international monitoring systems are discussed. Three bilateral or regional agreements are analyzed briefly to illustrate different possibilities: (1) the demilitarization of the Sinai region between Israel and Egypt in the 1970s; (2) the 1991 quadripartite agreement for monitoring nuclear facilities among Brazil, Argentina, The Argentine-Brazilian Agency for Accounting and Control of Nuclear Materials and the International Atomic Energy Agency; and (3) a bilateral Open Skies agreement between Hungary and Romania in 1991. These examples illustrate that the relationship of regional or bilateral arms control or security agreements to international agreements depends on a number of factors: the overlap of provisions between regional and international agreements; the degree of interest in a regional agreement among the international community; efficiency in implementing the agreement; and numerous political considerations.Given the importance of regional security to the international community, regions should be encouraged to develop their own infrastructure for implementing regional arms control and other security agreements. A regional infrastructure need not preclude participation in an international regime. On the contrary, establishing regional institutions for arms control and nonproliferation could result in more proactive participation of regional parties in developing solutions for regional and international problems, thereby strengthening existing and future international regimes. Possible first steps for strengthening regional infrastructures are identified and potential technical requirements are discussed.

  18. Expression analysis of NOS family and HSP genes during thermal stress in goat (Capra hircus).

    PubMed

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher (P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher (P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats. PMID:26205811

  19. Pedagogical Reflections by Secondary Science Teachers at Different NOS Implementation Levels

    NASA Astrophysics Data System (ADS)

    Herman, Benjamin C.; Clough, Michael P.; Olson, Joanne K.

    2015-10-01

    This study investigated what 13 secondary science teachers at various nature of science (NOS) instruction implementation levels talked about when they reflected on their teaching. We then determined if differences exist in the quality of those reflections between high, medium, and low NOS implementers. This study sought to answer the following questions: (1) What do teachers talk about when asked general questions about their pedagogy and NOS pedagogy and (2) what qualitative differences, if any, exist within variables across teachers of varying NOS implementation levels? Evidence derived from these teachers' reflections indicated that self-efficacy and perceptions of general importance for NOS instruction were poor indicators of NOS implementation. However, several factors were associated with the extent that these teachers implemented NOS instruction, including the utility value they hold for NOS teaching, considerations of how people learn, understanding of NOS pedagogy, and their ability to accurately and deeply self-reflect about teaching. Notably, those teachers who effectively implemented the NOS at higher levels value NOS instruction for reasons that transcend immediate instructional objectives. That is, they value teaching NOS for achieving compelling ends realized long after formal schooling (e.g., lifelong socioscientific decision-making for civic reasons), and they deeply reflect about how to teach NOS by drawing from research about how people learn. Low NOS implementers' simplistic notions and reflections about teaching and learning appeared to be impeding factors to accurate and consistent NOS implementation. This study has implications for science teacher education efforts that promote NOS instruction.

  20. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    NASA Astrophysics Data System (ADS)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P < 0.05) during peak summer, and iNOS and eNOS expressions were also observed to be significantly higher ( P < 0.05) during peak winter season as compared with moderate season. The iNOS, eNOS, cNOS, HSP70, and HSP90 were mainly localized in plasma membrane and cytoplasm of PBMCs. To conclude, data generated in the present study indicate the possible involvement of the NOS family genes in amelioration of thermal stress so as to maintain cellular integrity and homeostasis in goats.

  1. Probing the Hydrogen Bonding of the Ferrous–NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance

    PubMed Central

    Astashkin, Andrei V.; Chen, Li; Elmore, Bradley O.; Kunwar, Deepak; Miao, Yubin; Li, Huiying; Poulos, Thomas L.; Roman, Linda J.; Feng, Changjian

    2015-01-01

    Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site. It is of current interest to study structures of the heme species that activates O2 and transforms the substrate. The NOS ferrous–NO complex is a close mimic of the obligatory ferric (hydro)peroxo intermediate in NOS catalysis. In this work, pulsed electron–nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous–NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates. Unexpectedly, no H-bonding interaction connecting the NO ligand to the active site water molecule or the Arg substrate was detected, in contrast to the results obtained by X-ray crystallography for the Arg-bound nNOS heme domain [Li et al. J. Biol. Inorg. Chem. 2006, 11, 753–768]. The nearby exchangeable proton in both the no-substrate and Arg-containing nNOS samples is located outside the H-bonding range and, on the basis of the obtained structural constraints, can belong to the active site water (or OH). On the contrary, in the NOHA-bound sample, the nearby exchangeable hydrogen forms an H-bond with the NO ligand (on the basis of its distance from the NO ligand and a nonzero isotropic hfi constant), but it does not belong to the active site water molecule because the water oxygen atom (detected by 17O ENDOR) is too far. This hydrogen should therefore come from the NOHA substrate, which is in agreement with the X-ray crystallography work [Li et al. Biochemistry 2009, 48, 10246–10254]. The nearby nonexchangeable hydrogen atom assigned as Hɛ of Phe584 was detected in all three samples. This hydrogen atom may have a stabilizing effect on the NO ligand and probably determines its position. PMID:26035438

  2. Melanoma NOS1 expression promotes dysfunctional IFN signaling

    PubMed Central

    Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; De Giorgi, Valeria; Bedognetti, Davide; Dai, Cuilian; Uccellini, Lorenzo; Spivey, Tara; Pos, Zoltan; Thomas, Jaime; Reinboth, Jennifer; Murtas, Daniela; Zhang, Qianbing; Chouchane, Lotfi; Weiss, Geoffrey R.; Slingluff, Craig L.; Lee, Peter P.; Rosenberg, Steven A.; Alter, Harvey; Yao, Kaitai; Wang, Ena; Marincola, Francesco M.

    2014-01-01

    In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Comparison of gene transcription and array comparative genomic hybridization (aCGH) between melanoma cells from different patients indicated that suppression of IFN-α signaling correlates with an amplification of the NOS1 locus within segment 12q22-24. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α. Furthermore, in an explorative study, NOS1 expression in melanoma metastases was negatively associated with patient response to adoptive T cell therapy. This study provides a link between cancer cell phenotype and IFN signal dysfunction in circulating immune cells. PMID:24691438

  3. Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers

    PubMed Central

    Lai, Li; Ghebremariam, Yohannes T.

    2016-01-01

    Insulin resistance syndrome (IRS) is a configuration of cardiovascular risk factors involved in the development of metabolic disorders including type 2 diabetes mellitus. In addition to diet, age, socioeconomic, and environmental factors, genetic factors that impair insulin signaling are centrally involved in the development and exacerbation of IRS. Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal. The generation of NO by the NOS enzymes is known to contribute to vascular homeostasis including insulin-mediated skeletal muscle vasodilation and insulin sensitivity. By contrast, excessive inhibition of NOS enzymes by exogenous or endogenous factors is associated with insulin resistance (IR). Asymmetric dimethylarginine (ADMA) is an endogenous molecule that competitively inhibits all the NOS enzymes and contributes to metabolic perturbations including IR. The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. This review discusses the feasibility of the NOS/DDAH pathway as a novel target to develop vasoprotective insulin sensitizers. PMID:26770984

  4. Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice

    PubMed Central

    Champion, Hunter C.; Bivalacqua, Trinity J.; Greenberg, Stanley S.; Giles, Thomas D.; Hyman, Albert L.; Kadowitz, Philip J.

    2002-01-01

    It has been shown that mice deficient in the gene coding for endothelial nitric-oxide synthase (eNOS) have increased pulmonary arterial pressure and pulmonary vascular resistance. In the present study, the effect of transfer to the lung of an adenoviral vector encoding the eNOS gene (AdCMVeNOS) on pulmonary arterial pressure and pulmonary vascular resistance was investigated in eNOS-deficient mice. One day after intratracheal administration of AdCMVeNOS to eNOS−/− mice, there was an increase in eNOS protein, cGMP levels, and calcium-dependent conversion of l-arginine to l-citrulline in the lung. The increase in eNOS protein and activity in eNOS−/− mice was associated with a reduction in mean pulmonary arterial pressure and pulmonary vascular resistance when compared with values in eNOS-deficient mice treated with vehicle or a control adenoviral vector coding for β-galactosidase, AdCMVβgal. These data suggest that in vivo gene transfer of eNOS to the lung in eNOS−/− mice can increase eNOS staining, eNOS protein, calcium-dependent NOS activity, and cGMP levels and partially restore pulmonary arterial pressure and pulmonary vascular resistance to near levels measured in eNOS+/+ mice. Thus, the major finding in this study is that in vivo gene transfer of eNOS to the lung in large part corrects a genetic deficiency resulting from eNOS deletion and may be a useful therapeutic intervention for the treatment of pulmonary hypertensive disorders in which eNOS activity is reduced. PMID:12237402

  5. Particle Physics Masterclass as a Context for Learning about NOS

    NASA Astrophysics Data System (ADS)

    Wadness, Michael

    2011-04-01

    This research addresses the question: Do secondary school science students attending the U.S. Particle Physics Masterclass change their view of the nature of science (NOS)? The U.S. Particle Physics Masterclass is a national physics outreach program run by QuarkNet, in which high school physics students gather at a local research institution for one day to learn about particle physics and the scientific enterprise. Student activities include introductory lectures in particle physics, laboratory tours, analysis of actual data from CERN, and the discussion of their findings in a conference-like atmosphere. Although there are a number of outreach programs involving scientists in K-12 education, very few of them have been formally evaluated to determine if they provide adequate learning of NOS. Therefore, the significance of this study is that it investigates the claim that science outreach programs may be designed to address science literacy, specifically as a context for explicit NOS instruction.

  6. Signing of ESO-Poland Accession Agreement

    NASA Astrophysics Data System (ADS)

    2014-12-01

    An agreement was signed by Professor Lena Kolarska-Bobińska, the Polish Minister of Science and Higher Education, and the ESO Director General Tim de Zeeuw in Warsaw on 28 October 2014 that will lead to the country joining ESO. The signing of the agreement followed its unanimous approval by the ESO Council during an extraordinary meeting on 8 October 2014. Poland will be welcomed as a new Member State, following subsequent ratification of the accession agreement by the Polish Parliament. Tim de Zeeuw’s speech at this ceremony is reproduced below.

  7. Agreement on FY 1990 budget plan

    NASA Astrophysics Data System (ADS)

    The Bush administration has reached agreement with congressional leaders over a thumbnail version of the Fiscal Year 1990 budget. The plan contains few details but could have implications for NASA's Space Station Freedom and other big science projects.Overall, the budget agreement would achieve Gramm-Rudman-Hollings targets for budget deficit reduction without raising taxes, mostly through accounting manipulation and unspecified cuts in social programs. But a supplemental bill that calls for $1.2 billion in new spending for FY 1989 is expected to go to the House floor soon. That measure would violate the new agreement and add to the deficit.

  8. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false World Trade Organization... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement and Free Trade Agreements. (c) For acquisitions of supplies covered by the World Trade...

  9. 14 CFR 372.24 - Surety bond, depository agreement, escrow agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... company (1) whose surety bonds are accepted by the Interstate Commerce Commission under 49 CFR 1084.6; or... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Surety bond, depository agreement, escrow... § 372.24 Surety bond, depository agreement, escrow agreement. (a) Before selling or offering to...

  10. 14 CFR 372.24 - Surety bond, depository agreement, escrow agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... company (1) whose surety bonds are accepted by the Interstate Commerce Commission under 49 CFR 1084.6; or... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Surety bond, depository agreement, escrow... § 372.24 Surety bond, depository agreement, escrow agreement. (a) Before selling or offering to...

  11. 14 CFR 372.24 - Surety bond, depository agreement, escrow agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... company (1) whose surety bonds are accepted by the Interstate Commerce Commission under 49 CFR 1084.6; or... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Surety bond, depository agreement, escrow... § 372.24 Surety bond, depository agreement, escrow agreement. (a) Before selling or offering to...

  12. 7 CFR 3575.64 - Issuance of Lender's Agreement, Loan Note Guarantee, and Assignment Guarantee Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Programs Guaranteed Loans § 3575.64 Issuance of Lender's Agreement, Loan Note Guarantee, and Assignment... 7 Agriculture 15 2011-01-01 2011-01-01 false Issuance of Lender's Agreement, Loan Note Guarantee, and Assignment Guarantee Agreement. 3575.64 Section 3575.64 Agriculture Regulations of the...

  13. 7 CFR 1779.64 - Issuance of Lender's Agreement, Loan Note Guarantee, and Assignment Guarantee Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.64 Issuance of Lender's Agreement, Loan Note Guarantee... 7 Agriculture 12 2011-01-01 2011-01-01 false Issuance of Lender's Agreement, Loan Note Guarantee, and Assignment Guarantee Agreement. 1779.64 Section 1779.64 Agriculture Regulations of the...

  14. 14 CFR 372.24 - Surety bond, depository agreement, escrow agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... company (1) whose surety bonds are accepted by the Interstate Commerce Commission under 49 CFR 1084.6; or... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Surety bond, depository agreement, escrow... § 372.24 Surety bond, depository agreement, escrow agreement. (a) Before selling or offering to...

  15. 14 CFR 372.24 - Surety bond, depository agreement, escrow agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... company (1) whose surety bonds are accepted by the Interstate Commerce Commission under 49 CFR 1084.6; or... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Surety bond, depository agreement, escrow... § 372.24 Surety bond, depository agreement, escrow agreement. (a) Before selling or offering to...

  16. 48 CFR 1642.1204 - Agreement to recognize a successor in interest (novation agreement).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Novation and Change-of-Name Agreements 1642.1204 Agreement to recognize a successor in interest (novation agreement). (a) (FAR) 48 CFR 42.1204 shall be implemented as provided...

  17. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false World Trade Organization... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement and Free Trade Agreements. (c) For acquisitions of supplies covered by the World Trade...

  18. Exploring Elementary Science Methods Course Contexts to Improve Preservice Teachers' NOS of Science Conceptions and Understandings of NOS Teaching Strategies

    ERIC Educational Resources Information Center

    Akerson, Valarie L.; Weiland, Ingrid; Rogers, Meredith Park; Pongsanon, Khemmawaddee; Bilican, Kader

    2014-01-01

    We explored adaptations to an elementary science methods course to determine how varied contexts could improve elementary preservice teachers' conceptions of NOS as well as their ideas for teaching NOS to elementary students. The contexts were (a) NOS Theme in which the course focused on the teaching of science through the consistent teaching…

  19. Quick Guide: Power Purchase Agreements (Fact Sheet)

    SciTech Connect

    Not Available

    2011-07-01

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  20. 75 FR 22408 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... under the Shipping Act of 1984. Interested parties may submit comments on the agreements to the.... between the ports of Port Everglades, FL and George Town, Grand Cayman. By Order of the Federal...

  1. 77 FR 72349 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... & Logistic GMBH & Co. KG; Industrial Maritime Carriers LLC; Seaboard Marine, Ltd.; and West Coast Industrial... amendment removes BBC Chartering & Logistic GMBH & Co. KG as a party to the agreement. By Order of...

  2. 42 CFR 460.154 - Enrollment agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.154 Enrollment agreement. If the...

  3. 42 CFR 460.154 - Enrollment agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.154 Enrollment agreement. If the...

  4. 42 CFR 460.154 - Enrollment agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.154 Enrollment agreement. If the...

  5. Appendix G: Peer review nondisclosure agreement

    SciTech Connect

    None, None

    2009-01-18

    This peer review nondisclosure agreement should be signed by each reviewer prior to the program sending review materials if sensitive or proprietary information will be provided reviewers or discussed during the review, and to everyone attending a review.

  6. 77 FR 28880 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ...; 1850 M Street NW., Suite 900; Washington, DC 20036. Synopsis: The Agreement would add the U.S. Gulf Coast, Mediterranean Sea, Persian Gulf, Gulf of Aden, Black Sea, Gulf of Oman and Indian Ocean to...

  7. 78 FR 17234 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... (DFS) Negotiated Service Agreement (NSA) to the market dominant product list.\\1\\ After a ] comment... dominant product list.\\2\\ On March 8, 2013, the Postal Service filed an amendment to the DFS NSA with...

  8. 24 CFR 7.43 - Settlement agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and/or their designees; and (4) Otherwise comply with 29 CFR part 1614. (b) Any settlement agreement... Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal Remedies,...

  9. 24 CFR 7.43 - Settlement agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and/or their designees; and (4) Otherwise comply with 29 CFR part 1614. (b) Any settlement agreement... Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal Remedies,...

  10. 24 CFR 7.43 - Settlement agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and/or their designees; and (4) Otherwise comply with 29 CFR part 1614. (b) Any settlement agreement... Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal Remedies,...

  11. 24 CFR 7.43 - Settlement agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and/or their designees; and (4) Otherwise comply with 29 CFR part 1614. (b) Any settlement agreement... Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal Remedies,...

  12. 78 FR 17205 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ....: 011426-054. Title: West Coast of South America Discussion Agreement. Parties: Compania Chilena de...; Seaboard Marine Ltd.; South Pacific Shipping Company, Ltd. (dba Ecuadorian Line); and Trinity Shipping...

  13. 75 FR 46938 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... No.: 011426-048. Title: West Coast of South America Discussion Agreement. Parties: A.P. Moller-Maersk....; Mediterranean Shipping Company, SA; Seaboard Marine Ltd.; South Pacific Shipping Company, Ltd.; and...

  14. 77 FR 48983 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... President Lines, Ltd./APL Co. Pte Ltd.(withdrawal from agreement effective September 1, 2012); COSCO... deletes American President Lines, Ltd. and APL Co. PTE Ltd. (operating as a single carrier) from...

  15. 77 FR 58140 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... increases CMA CGM's slot allocation via implementing a structural purchase. Agreement No.: 012118-002. Title... supplement to pay for the fender improvements to Berth 1. By Order of the Federal Maritime Commission....

  16. Form 5-Mining venture agreement model form

    SciTech Connect

    Not Available

    1984-01-01

    This text acts as a reference of the basic terms and conditions for a negotiated mining venture agreement. Alternative clauses and provisions, along with extensive commentary, are supplied. The model form contains many articles which define and detail the process.

  17. 77 FR 65886 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Lines, Ltd. and Crowley Liner Services/Crowley Caribbean Services, LLC as parties to the agreement... amendment reflects the resignation of Bernuth Lines, Ltd. and Crowley Liner Services, Inc./Crowley...

  18. 78 FR 13341 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... Carriers, Inc. and Kawasaki Kisen Kaisha, Ltd. ] Filing Party: John P. Meade, Esq.; Vice-President; K-Line... geographic scope of the agreement and updates the address of Kawasaki Kisen Kaisha, Ltd. By Order of...

  19. 45 CFR 630.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... carrying out the activity contemplated by the award. The term does not include cooperative research and development agreements as defined in 15 U.S.C. 3710a....

  20. 76 FR 41794 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Services Limited; and King Ocean Service de Venezuela, S.A. Filing Party: Wayne Rohde, Esq.; Cozen O'Connor... address of Hamburg Sud, and removes King Ocean Service de Venezuela, S.A. as a participant. Agreement...

  1. 75 FR 14159 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...-Lloyd USA LLC; Nippon Yusen Kaisha; Orient Overseas Container Line, Inc.; Orient Overseas Container Line...: Grand Alliance/Zim/HSDG Atlantic Space Charter Agreement. Parties: Hapag-Lloyd AG, Nippon Yusen...

  2. 75 FR 78245 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... Shipping Container Lines Co. Ltd., China Shipping Container Lines (Hong Kong) Co. Ltd., and Compania Sud..., including China, Hong Kong, and Korea. Agreement No.: 012114. Title: POS/TSL Vessel Sharing...

  3. 75 FR 24702 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    .... Agreement No.: 201206. Title: Port of Philadelphia Marine Terminal Association, Inc. Parties: Delaware River... X. Scanlan, Esq.; Scanlan and Scanlan; Post Office Box 120; Bryn Mawr, PA 19010. Synopsis:...

  4. Quick Guide: Power Purchase Agreements (Fact Sheet)

    SciTech Connect

    Not Available

    2010-06-01

    Introduction to Federal power purchase agreements (PPAs), including available FEMP services and technical assistance as well as questions to ask when evaluating PPAs for a Federal renewable energy project.

  5. 76 FR 76411 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Lines Co., Ltd., China Shipping Container Lines (Hong Kong) Co., Ltd., and Hainan P O Shipping Co., Ltd.... Synopsis: The agreement authorizes China Shipping to charter space to Hainan P O in the trade between the...

  6. 75 FR 82025 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ....: 012057-005. Title: CMA CGM/Maersk Line Space Charter, Sailing and Cooperative Working Agreement Asia to... trade between the U.S. West Coast and ports on the Pacific Coasts of Mexico, Canada and Central...

  7. 77 FR 23248 - Notice of Agreement Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ....: 012164. Title: KL/WHS Space Charter and Sailing Agreement. Parties: Kawasaki Kisen Kaisha, Ltd. and Wan... Line and Wan Hai to charter space on their respective vessels, coordinate their sailings, and...

  8. 75 FR 12748 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ....: 012092. Title: MOL/``K'' Line Space Charter and Sailing Agreement. Parties: Kawasaki Kisen Kaisha, Ltd... exchange slots and to coordinate sailings in the trades between the U.S. Pacific Coast and Japan,...

  9. 24 CFR 7.43 - Settlement agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and/or their designees; and (4) Otherwise comply with 29 CFR part 1614. (b) Any settlement agreement... Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal Remedies,...

  10. 48 CFR 41.206 - Interagency agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-service agreements) when acquiring utility service or facilities from other Government agencies and shall comply with the policies and procedures at subpart 17.5, Interagency Acquisitions under the Economy Act....

  11. 78 FR 53455 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... Space Charter Agreement. Parties: Hamburg Sud and Hapag-Lloyd AG. Filing Party: Wayne R. Rohde, Esq... Hamburg Sud to charter space to Hapag-Lloyd in the trade between the U.S. Atlantic Coast, and ports...

  12. 7 CFR 1415.17 - Cooperative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in perpetuity, except where State law prohibits a permanent easement. (e) The entity may use its own... option to enter into an agreement with governmental or private organizations to carry out...

  13. 4. Southwest fronts, dock nos. 491 and 492. Southeast end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Southwest fronts, dock nos. 491 and 492. Southeast end, dock no. 492. View to north. - Offutt Air Force Base, Looking Glass Airborne Command Post, Nose Docks, On either side of Hangar Access Apron at Northwest end of Project Looking Glass Historic District, Bellevue, Sarpy County, NE

  14. Airfield setting of Facility Nos. 175 and 176, taken from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Airfield setting of Facility Nos. 175 and 176, taken from north end of Ford Island Runway, with landplane hangars on the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  15. Building Nos. 92, 381, and 392, view into common courtyard ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building Nos. 92, 381, and 392, view into common courtyard between 92 (right), 391 (center deep), and 392 (left), view facing west-northwest - U.S. Naval Base, Pearl Harbor, Marine Railway No. 1 Accessories House & Apprentice Welding School, Additions, Intersection of Avenue B & Sixth Street, Pearl City, Honolulu County, HI

  16. 15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I and II (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  17. 21. INTERIOR VIEW OF REFINING MILL, SHOWING LOCATIONS OF NOS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. INTERIOR VIEW OF REFINING MILL, SHOWING LOCATIONS OF NOS. 1, 2, AND 3 MILLS, LOOKING SOUTH. SOME OF THE MACHINERY IN THIS SECTION HAS BEEN REMOVED. - Clay Spur Bentonite Plant & Camp, Refining Mill, Clay Spur Siding on Burlington Northern Railroad, Osage, Weston County, WY

  18. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    ERIC Educational Resources Information Center

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  19. AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AIRMEN'S BARRACKS (FACILITY Nos. 422, 442, AND 420) IN MIDDLE DISTANCE, ALSO SHOWING ESCOLTA AVENUE AT RIGHT, LOOKING SOUTHEAST FROM RESERVOIR HILL. (Part 2 of a 3 view panorama; see also CA-2398-4 and CA-2398-6.) - Hamilton Field, East of Nave Drive, Novato, Marin County, CA

  20. 76 FR 80890 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ...-01, issued on September 20, 2010 (73 FR 78724), authorizes the permit holder to receive, import...-01, (73 FR 25668) issued on April 30, 2008 authorizes the permit holder to collect, receive and... permits: the National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston,...

  1. Service building. Cross section thru dry dock nos. 4 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Service building. Cross section thru dry dock nos. 4 & 5 showing service bldg & 20-75-150 ton cranes (dry dock associates, May 23, 1941). In files of Cushman & Wakefield, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  2. 77 FR 67631 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... species recovery in four facilities in the Southeast Region of the USFWS. Research would include nutrition... National Oceanic and Atmospheric Administration RIN 0648-XC348 Endangered Species; File Nos. 17367 and... of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the...

  3. 76 FR 15300 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... from the NMFS recovery plan outline for this species. The permits would not authorize any takes from... National Oceanic and Atmospheric Administration RIN 0648-XA306 Endangered Species; File Nos. 16266 and... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et...

  4. Tool nos. 277 and 2201, details for bending machine, Johnson ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Tool nos. 277 and 2201, details for bending machine, Johnson Company, Johnstown, Pa. Scale 3 inches - 1 ft, Feb 13th 1893, drawing number 15098. (Photograph of drawing held at the Johnstown Corporation General Office, Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  5. Context view, Building Nos. 2729, with Building No. 28 in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view, Building Nos. 27-29, with Building No. 28 in the center, looking west at front of buildings, from a spot south of Building No. 29 - U.S. Veterans Hospital, Jefferson Barracks, Medical Officer in Charge Residence, VA Medical Center, Jefferson Barracks Division 1 Jefferson Barracks Drive, Saint Louis, Independent City, MO

  6. Context view, Building Nos. 2728, looking north from a spot ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view, Building Nos. 27-28, looking north from a spot south of Building No. 28 - U.S. Veterans Hospital, Jefferson Barracks, Medical Officer in Charge Residence, VA Medical Center, Jefferson Barracks Division 1 Jefferson Barracks Drive, Saint Louis, Independent City, MO

  7. Langley VEDIT for NOS/VE usage manual

    NASA Technical Reports Server (NTRS)

    Heaney, Margaret A.

    1987-01-01

    The use of the VEDIT editor on the CDC Network Operating System/Virtual Environment (NOS/VE) is discussed. The VEDIT, a utility, allows a user to edit files line by line (line mode). How to access and the use of VEDIT are explained. The parameters and the format of the individual commands are defined. Examples are included.

  8. 16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III and IV (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  9. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    PubMed Central

    Morsy, Mohamed A.; Ibrahim, Salwa A.; Amin, Entesar F.; Kamel, Maha Y.; Rifaai, Rehab A.; Hassan, Magdy K.

    2014-01-01

    Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p.) for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS) expression, while expression of endothelial nitric oxide synthase (eNOS) was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production. PMID:25120567

  10. Clock Agreement Among Parallel Supercomputer Nodes

    DOE Data Explorer

    Jones, Terry R.; Koenig, Gregory A.

    2014-04-30

    This dataset presents measurements that quantify the clock synchronization time-agreement characteristics among several high performance computers including the current world's most powerful machine for open science, the U.S. Department of Energy's Titan machine sited at Oak Ridge National Laboratory. These ultra-fast machines derive much of their computational capability from extreme node counts (over 18000 nodes in the case of the Titan machine). Time-agreement is commonly utilized by parallel programming applications and tools, distributed programming application and tools, and system software. Our time-agreement measurements detail the degree of time variance between nodes and how that variance changes over time. The dataset includes empirical measurements and the accompanying spreadsheets.

  11. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  12. Cooperative research and development agreements at METC

    SciTech Connect

    Ludlow, J.C.; Jarr, L.A.; Anderson, R.J.

    1995-06-01

    The Federal Technology Transfer Act of 1986 (P.L. 99-502) provided a new mechanism for joint research between private parties and the Morgantown Energy Technology Center (METC). Joint projects under this law are called Cooperative Research And Development Agreements (CRADAs) and are simply agreements between METC and the private sector to work together on a mutually beneficial project. Of primary interest to METC is the development and deployment of: (1) clean, efficient power generation technologies, (2) technologies for the characterization and exploitation of the Nation`s natural gas resource, and (3) environmental remediation technologies.

  13. Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum.

    PubMed

    Di Girolamo, G; Farina, M; Riberio, M L; Ogando, D; Aisemberg, J; de los Santos, A R; Martí, M L; Franchi, A M

    2003-07-01

    1. The therapeutic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is thought to be due mainly to its inhibition of cyclooxygenase (COX) enzymes, but there is a growing body of research that now demonstrates a variety of NSAIDs effects on cellular signal transduction pathways other than those involving prostaglandins. 2. Nitric oxide (NO) as a free radical and an agent that gives rise to highly toxic oxidants (peroxynitrile, nitric dioxide, nitron ion), becomes a cause of neuronal damage and death in some brain lesions such as Parkinson and Alzheimer disease, and Huntington's chorea. 3. In the present study, the in vivo effect of three NSAIDs (lysine clonixinate (LC), indomethacine (INDO) and meloxicam (MELO)) on NO production and nitric oxide synthase expression in rat cerebellar slices was analysed. Rats were treated with (a) saline, (b) lipopolysaccharide (LPS) (5 mg kg(-1), i.p.), (c) saline in combination with different doses of NSAIDs and (d) LPS in combination with different doses of NSAIDs and then killed 6 h after treatment. 4. NO synthesis, evaluated by Bred and Snyder technique, was increased by LPS. This augmentation was inhibited by coadministration of the three NSAIDs assayed. None of the NSAIDs tested was able to modify control NO synthesis. 5. Expression of iNOS and neural NOS (nNOS) was detected by Western blotting in control and LPS-treated rats. LC and INDO, but not MELO, were able to inhibit the expression of these enzymes. 6. Therefore, reduction of iNOS and nNOS levels in cerebellum may explain, in part, the anti-inflammatory effect of these NSAIDs and may also have importance in the prevention of NO-mediated neuronal injury. PMID:12871835

  14. Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum

    PubMed Central

    DiGirolamo, G; Farina, M; Riberio, M L; Ogando, D; Aisemberg, J; de los Santos, A R; Martí, M L; Franchi, A M

    2003-01-01

    The therapeutic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is thought to be due mainly to its inhibition of cyclooxygenase (COX) enzymes, but there is a growing body of research that now demonstrates a variety of NSAIDs effects on cellular signal transduction pathways other than those involving prostaglandins. Nitric oxide (NO) as a free radical and an agent that gives rise to highly toxic oxidants (peroxynitrile, nitric dioxide, nitron ion), becomes a cause of neuronal damage and death in some brain lesions such as Parkinson and Alzheimer disease, and Huntington's chorea. In the present study, the in vivo effect of three NSAIDs (lysine clonixinate (LC), indomethacine (INDO) and meloxicam (MELO)) on NO production and nitric oxide synthase expression in rat cerebellar slices was analysed. Rats were treated with (a) saline, (b) lipopolysaccharide (LPS) (5 mg kg−1, i.p.), (c) saline in combination with different doses of NSAIDs and (d) LPS in combination with different doses of NSAIDs and then killed 6 h after treatment. NO synthesis, evaluated by Bred and Snyder technique, was increased by LPS. This augmentation was inhibited by coadministration of the three NSAIDs assayed. None of the NSAIDs tested was able to modify control NO synthesis. Expression of iNOS and neural NOS (nNOS) was detected by Western blotting in control and LPS-treated rats. LC and INDO, but not MELO, were able to inhibit the expression of these enzymes. Therefore, reduction of iNOS and nNOS levels in cerebellum may explain, in part, the anti-inflammatory effect of these NSAIDs and may also have importance in the prevention of NO-mediated neuronal injury. PMID:12871835

  15. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    PubMed

    Sapp, April M; Mogen, Austin B; Almand, Erin A; Rivera, Frances E; Shaw, Lindsey N; Richardson, Anthony R; Rice, Kelly C

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  16. Contribution of the nos-pdt Operon to Virulence Phenotypes in Methicillin-Sensitive Staphylococcus aureus

    PubMed Central

    Almand, Erin A.; Rivera, Frances E.; Shaw, Lindsey N.; Richardson, Anthony R.; Rice, Kelly C.

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  17. Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population.

    PubMed

    Chen, Feng; Li, Yu-Mei; Yang, Lin-Qing; Zhong, Cai-Gao; Zhuang, Zhi-Xiong

    2016-07-01

    Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM). The present study aims to detect the potential association of NOS2 and NOS3 gene polymorphisms with the susceptibility toT2DM and diabetic nephropathy (DN) in the Chinese Han population. Four hundred and ninety T2DM patients and 485 healthy controls were enrolled in this case-control study. The genotypes of NOS2 and NOS3 gene polymorphisms were analyzed by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method. Our data demonstrated that the NOS2 rs2779248 and NOS2 rs1137933 genetic polymorphisms were significantly associated with the increased susceptibility to T2DM in the heterozygote comparison, dominant model, and allele contrast; and NOS3 rs3918188 genetic polymorphism was significantly associated with the increased susceptibility to T2DM in the homozygote comparison and recessive model. The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM. And a significant haplotype effect of NOS2 rs10459953/C- rs1137933/G- rs2779248/T was found between T2DM cases and controls. Moreover, NOS3 rs1800783 polymorphism was significantly associated with the increased susceptibility to DN in the heterozygote comparison, recessive model and allele contrast. At last, a positive correlation of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the

  18. 78 FR 20360 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ...), which was added to the competitive product list in this docket.\\1\\ In its Notice, the Postal Service... Service Contract 2 to Competitive Product List and Notice of Filing (Under Seal) of Contract and... COMMISSION Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY:...

  19. 77 FR 43867 - Negotiated Service Agreement Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Negotiated Service Agreement Amendment AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently-filed Postal Service request concerning a change in the termination date of.... Ordering Paragraphs I. Introduction On July 19, 2012, the Postal Service filed notice that it has agreed...

  20. 24 CFR 700.140 - Participatory agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Participatory agreement. 700.140 Section 700.140 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF THE SECRETARY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HOUSING ASSISTANCE...