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Sample records for aid future research

  1. The Oral HIV/AIDS Research Alliance Program: lessons learned and future directions.

    PubMed

    Shiboski, C H; Webster-Cyriaque, J Y; Ghannoum, M; Dittmer, D P; Greenspan, J S

    2016-04-01

    The Oral HIV/AIDS Research Alliance (OHARA) was established in 2006 to provide the capacity to investigate the oral complications associated with HIV/AIDS within the ACTG infrastructure. Its goals were to explore the effects of potent antiretroviral therapy (ART) on the development of opportunistic infections, and variation and resistance of opportunistic pathogens in the context of immune suppression and long-term ART. The objectives of this talk, presented as part of a plenary session at the 7th World Workshop on Oral Health and Disease in AIDS, were to (i) provide an overview of OHARA's most recent research agenda, and how it evolved since OHARA's inception; (ii) describe OHARA's main accomplishments, including examples of research protocols completed and their key findings; and (iii) describe spin-off projects derived from OHARA, lessons learned, and future directions. OHARA has met its central goal and made key contributions to the field in several ways: (i) by developing/updating diagnostic criteria for oral disease endpoints commonly measured in OHARA protocols and in HIV/AIDS research in general and has creating standardized training modules, both for measuring these oral disease endpoints across clinical specialties, and for collecting oral fluid specimens; (ii) by implementing a total of nine protocols, six of which are completed. Three protocols involved domestic research sites, while three involved international research sites (in Africa, India, and South America); (iii) and by developing and validating a number of laboratory assays used in its protocols and in the field of oral HIV/AIDS research. PMID:27109281

  2. HIV, AIDS, and the Future

    MedlinePlus

    ... Navigation Bar Home Current Issue Past Issues HIV / AIDS HIV, AIDS, and the Future Past Issues / Summer 2009 Table ... and your loved ones from HIV/AIDS. The AIDS Memorial Quilt In 1987, a total of 1, ...

  3. Oral manifestations of HIV/AIDS in Asia: Systematic review and future research guidelines

    PubMed Central

    Oberoi, Sukhvinder-Singh; Vohra, Puneeta; Nagpal, Archna

    2015-01-01

    Objectives The authors have conducted a systematic review of oral manifestations of HIV from studies conducted in Asia to establish the characteristics and prevalence of individual oral manifestations in Asia, and to assess the direction of future research studies on oral manifestations of HIV in Asia. Material and Methods The electronic retrieval systems and databases searched for relevant articles were PubMed [MEDLINE], EBSCO, and EMBASE. The search was for limited articles published in English or with an English abstract and articles published during the period January 1995 to August 2014. The authors reached a final overall sample of 39 studies that were conducted in Asia. Results The median population size among all studies was 312.7 patients. Oral candidiasis [OC] was the most common oral manifestation [37.7%] in studies conducted in Asia. The overall prevalence of oral hairy leukoplakia and melanotic hyperpigmentation was computed to be 10.1% and 22.8% respectively. Thailand and India are primarily countries with maximum research on oral manifestations. Conclusions The research on oral manifestations of HIV in Asia has to upgrade to more interventional and therapeutic studies rather than the contemporary cross- sectional epidemiological descriptive studies. The authors have given suggestions and future directions for the implementation of clinical research of oral manifestations in HIV patients. Key words:Oral manifestations, HIV/AIDS, Asia, Systematic review. PMID:26330942

  4. HIV, AIDS, and the Future

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues HIV / AIDS HIV, AIDS, and the Future Past Issues / Summer 2009 ... turn Javascript on. Photo: The NAMES Project Foundation HIV and AIDS are a global catastrophe. While advances ...

  5. Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008.

    PubMed

    Joseph, Jeymohan; Clifford, David; Douglas, Steven D; Fox, Howard; Gendelman, Howard E; Gonzalez-Scarano, Francisco; Grant, Igor; Major, Eugene; McArthur, Justin

    2009-09-01

    The National Institute of Mental Health in cooperation with the National Institute on Drug Abuse and the National Institute of Neurological Disorders and Stroke organized a meeting on July 24-25, 2008 to develop novel research directions for neuroAIDS research. The deliberations of this meeting are outlined in this brief report. Several critical research areas in neuroAIDS were identified as areas of emphasis. Opportunities for collaborations between large NIH-funded projects were also discussed. PMID:19455426

  6. African-American sexuality and HIV/AIDS: recommendations for future research.

    PubMed

    Wyatt, Gail E; Williams, John K; Myers, Hector F

    2008-01-01

    HIV/AIDS continues to create a significant health crisis in African-American communities and health disparities within the United States. Understanding African-American sexuality within a culturally congruent and ethnocentric approach is critical to decreasing the HIV infection and transmission rates for African Americans. This brief discusses two major factors: 1) confusion about race-based stereotypes; and 2) historical health disparities and mistrust, which have influenced our understanding of African-American sexuality despite that fact that very little research has been conducted in this area. This paper discusses the limitations of what is known and makes recommendations for research surrounding sexuality and HIV/AIDS. Research trainings for new and established investigators and collaborations among health, community, religious, political organizations, and historically black colleges and universities are needed to disseminate relevant HIV prevention messages. Conducting research to better understand African-American sexuality will facilitate the development of behavioral interventions that address health, HIV and mental health risk reduction within the context of African-American life. PMID:18277807

  7. American Foundation for AIDS Research

    MedlinePlus

    ... the Press Corporate Support amfAR, The Foundation for AIDS Research Research Overview Research Grants Research Accomplishments Scientific ... Archive TREAT Asia TREAT Asia About TREAT Asia AIDS in Asia Research and Treatment Education and AIDS ...

  8. AIDS Researcher Gives Retrospective

    ERIC Educational Resources Information Center

    Hawkins, B. Denise

    2011-01-01

    Nearly 30 years ago, renowned immunologist James E.K. Hildreth, M.D., Ph.D., was compelled to start researching the virus that causes AIDS. He marveled at its enigma and was pressed into action by its ability to cut lives short and devastate communities. The disease set him on a course of medical inquiry that has included biomedical breakthroughs…

  9. Mental Health and Resilience in HIV/AIDS-Affected Children: A Review of the Literature and Recommendations for Future Research

    PubMed Central

    Betancourt, T.S.; Meyers-Ohki, S.E.; Charrow, A.; Hansen, N.

    2012-01-01

    Background To date, research on mental health in HIV-affected children (children who have an HIV-positive caregiver or live with the virus themselves) has focused on risk factors associated with the disease. However, simultaneous identification of factors that contribute to resilience in the face of risks is also needed. A greater understanding of modifiable protective processes that contribute to resilience in the mental health of children affected by HIV can inform the design of interventions that bolster naturally-occurring supports and contribute to early prevention or better management of risks. Methods We reviewed the recent literature on mental health and resilience in children and adolescents affected by HIV/AIDS. Literature searches of PsycInfo and PubMed were conducted during July-December 2011 consistent with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. Qualitative and quantitative studies were included for review if primary research questions pertained to mental health and coping or protective processes in children and families affected by HIV/AIDS. All studies subject to full review were evaluated for quality using a modified Systematic Assessment of Quality in Observational Research (SAQOR) rating system. Results 171 unique studies were returned from online searches of the literature and bibliography mining. Of these, 29 were evaluated as pertaining directly to mental health and resilience in families and children living with HIV/AIDS. Eight studies presented qualitative analyses. Ten quantitative studies examined individual resources contributing to child resilience and four quantitative studies looked at family-level resources. Ten studies also investigated community-level interactions. Four presented findings from resilience-focused interventions. Conclusions There is a clear need for rigorous research on mental health and resilience in HIV-affected children and adolescents. The evidence base would greatly

  10. Human Subjects Issues in AIDS Research.

    ERIC Educational Resources Information Center

    Bayer, Ronald, Ed.

    1990-01-01

    Six articles are presented on the use of human subjects in research on acquired immune deficiency syndrome (AIDS). Topics include the ethics of human experimentation, female and pediatric AIDS patients, Human Immunodeficiency Virus (HIV) infection and AIDS among correctional inmates, community-based AIDS research, and clinical trials of HIV…

  11. Financial aid policy: lessons from research.

    PubMed

    Dynarski, Susan; Scott-Clayton, Judith

    2013-01-01

    In the nearly fifty years since the adoption of the Higher Education Act of 1965, financial aid programs have grown in scale, expanded in scope, and multiplied in form. As a result, financial aid has become the norm among college enrollees. Aid now flows not only to traditional college students but also to part-time students, older students, and students who never graduated from high school. Today aid is available not only to low-income students but also to middle- and even high-income families, in the form of grants, subsidized loans, and tax credits. The increasing size and complexity of the nation's student aid system has generated questions about effectiveness, heightened confusion among students and parents, and raised concerns about how program rules may interact. In this article, Susan Dynarski and Judith Scott-Clayton review what is known, and just as important, what is not known, about how well various student aid programs work. The evidence, the authors write, clearly shows that lowering costs can improve college access and completion. But this general rule is not without exception. First, they note, the complexity of program eligibility and delivery appears to moderate the impact of aid on college enrollment and persistence after enrollment. Second, for students who have already decided to enroll, grants that tie financial aid to academic achievement appear to boost college outcomes such as persistence more than do grants with no strings attached. Third, compared with grant aid, relatively little rigorous research has been conducted on the effectiveness of student loans. The paucity of evidence on student loans is particularly problematic both because they represent a large share of student aid overall and because their low cost (relative to grant aid) makes them an attractive option for policy makers. Future research is likely to focus on several issues: the importance of program design and delivery, whether there are unanticipated interactions between

  12. Research Report: HIV/AIDS

    MedlinePlus

    ... Reports » HIV/AIDS » Letter from the Director HIV/AIDS Email Facebook Twitter Letter from the Director Human ... the virus that causes acquired immune deficiency syndrome (AIDS) — has been with us for three decades now. ...

  13. The Future of Research

    ERIC Educational Resources Information Center

    Universities UK, 2010

    2010-01-01

    This report looks at the future opportunities and challenges facing the UK university research base and makes recommendations as to how the system can respond to these. It comes at a time when the UK has elected its first coalition government for 70 years and is facing unprecedented economic challenges. The report is aimed at policy makers…

  14. Annual Research Review: Mental Health and Resilience in HIV/AIDS-Affected Children--A Review of the Literature and Recommendations for Future Research

    ERIC Educational Resources Information Center

    Betancourt, Theresa S.; Meyers-Ohki, Sarah E.; Charrow, Alexandra; Hansen, Nathan

    2013-01-01

    Background: To date, research on mental health in HIV-affected children (children who have an HIV-positive caregiver or live with the virus themselves) has focused on risk factors associated with the disease. However, simultaneous identification of factors that contribute to resilience in the face of risks is also needed. A greater understanding…

  15. Student Aid Research. A Manual for Financial Aid Administrators.

    ERIC Educational Resources Information Center

    Davis, Jerry Sheehan, Ed.

    This manual contains nine articles intended to assist student financial aid professionals in conducting research. Initial chapters provide basic information for those starting to do such research while later chapters deal with more complex issues. Some chapters include appendices that provide examples of the techniques under consideration. from…

  16. National Institutes of Health, Office of AIDS Research

    MedlinePlus

    ... Contact Us Main Navigation for the Office of AIDS Research Homepage ABOUT OAR SCIENTIFIC AREAS STRATEGIC PLAN ... HIV/AIDS INFORMATION Welcome to the Office of AIDS Research. Welcome to the Office of AIDS Research ...

  17. Interdisciplinary andrology. STDs. AIDS research.

    PubMed

    Hafez, E S

    1987-01-01

    Multidisciplinary andrology deals with clinical application and modern technology for the evaluation and differential diagnosis of male infertility with emphasis on morphological, anatomical, biochemical, immunological, hereditary, and microbiological parameters. Little is known about the effects of diet, disease, stress, environmental, and drugs on male-related unexplained infertility of couples. Regional, national, and international centers of multidisciplinary andrology should provide (1) extensive and unique clinical services; (2) a computerized "patient referral center," (3) self-learning packages (slides/tape programs) for patients; and (4) a computer link to the National Library of Medicine and the Drug Information Center. Specialized laboratories and clinics can be served by expert consultants, visiting professors, bilingual and well-trained clinicians, nurses, laboratory technologists, computer operators, and related allied health personnel. Patient education pamphlets, updated every few years, can be distributed during training workshops when an extensive network of remote teleprinters can be utilized. Qualified client location may install a printer to allow on-site printing of reports in the shortest possible time. Special mailing containers are provided to clients who wish to mail their laboratory specimens. Other clinical services may include the following: 1. Central source of communication and information in andrology; 2. International roster of multidisciplinary andrology centers; 3. Patient referral to centers and consultations for developing countries; 4. Screening of husbands and wives for in vitro fertilization/embryo transfer (IVF/ET); 5. Screening of couples with unexplained infertility for sexually transmitted diseases (STDs) including AIDS; 6. Exchange of research material and methodology; 7. Coordination of multicenter research; 8. Organizing training workshops for clinicians, nurses, and laboratory technicians; 9. Establishing a repository

  18. Future in Psychopathology Research

    PubMed Central

    Heckers, Stephan

    2014-01-01

    Psychopathology research has focused either on the analysis of the mental state in the here and now or on the synthesis of mental status abnormalities with biological markers and outcome data. These two schools of psychopathology, the analytic and the synthetic, make contrasting assumptions, take different approaches, and pursue divergent goals. Analytic psychopathology favors the individual person and unique biography, whereas synthetic psychopathology abstracts from the single case and generalizes to the population level. The dimension of time, especially the prediction of future outcomes, is viewed differently by these two schools. Here I outline how Carpenter’s proposal of strong inference and theory testing in psychopathology research can be used to test the value of analytic and synthetic psychopathology. The emerging field of personalized psychiatry can clarify the relevance of psychopathology for contemporary research in psychiatry. PMID:24562493

  19. ABLE: The Future of Mechanical Aids.

    ERIC Educational Resources Information Center

    Lowell, Harvey; Finkelstein, Stan

    1989-01-01

    Advanced Bio-Mechanical Linkage Enablement (ABLE) technology constitutes a leap forward in physical aids for people with disabilities, as they integrate high technologies in rehabilitation to create individualized self-contained care systems. Described are the need for universal standards, barriers to acceptance of ABLE technologies, and ways to…

  20. Research Into Educational Futures.

    ERIC Educational Resources Information Center

    Spitzer, Dean R.

    A series of articles examines the subject of educational futures, including discussions of the relevance of the topic to the training of teachers and librarians. Three games for future forecasting (SCIFI, AFAR and FAR) and a mini-delphi technique are included. A scheme for viewing alternative futures in Educational Technology through the use of…

  1. The U.S. and AIDS Research.

    ERIC Educational Resources Information Center

    Burd, Stephen

    1994-01-01

    Despite key changes in the federal Acquired Immune Deficiency Syndrome (AIDS) research program, activists and some scientists are frustrated that not enough has been done and the actions taken have not had sufficient impact on the problem. Controversy over basic vs. clinical-trial research persists. (MSE)

  2. Museum Education Research: Future Directions.

    ERIC Educational Resources Information Center

    Journal of Museum Education: Roundtable Reports, 1986

    1986-01-01

    Six museum education and learning researchers discuss the need to study how people learn and behave in museums and what kind of current research studies should be undertaken. Mary Ellen Munley, in "Back to the Future: A Call for Coordinated Research Programs in Museums," describes the differences between the terms "evaluation,""audience research,"…

  3. Future Skills. Research Brief

    ERIC Educational Resources Information Center

    Walker, Karen

    2004-01-01

    Most of the occupations for which students need to be prepared have not yet been designed, however, it is acknowledged that the majority of employment will be in service related fields. According to the research, the jobs most people will perform will only exist for three to five years, therefore, training for a specific job is not what is…

  4. TARGET: Research in Computer Aids for Translators.

    ERIC Educational Resources Information Center

    McCracken, Donald; Strazds, Andris E.

    1980-01-01

    Reviews the background of the "TARGET Project for Aids to Translation," its current facilities, and its goals. Describes the system's central feature as an interactive, multilingual terminology database intended to eliminate time wasted in researching unknown terms and to facilitate final document production, study of person-machine interface…

  5. The future of computer-aided sperm analysis.

    PubMed

    Mortimer, Sharon T; van der Horst, Gerhard; Mortimer, David

    2015-01-01

    Computer-aided sperm analysis (CASA) technology was developed in the late 1980s for analyzing sperm movement characteristics or kinematics and has been highly successful in enabling this field of research. CASA has also been used with great success for measuring semen characteristics such as sperm concentration and proportions of progressive motility in many animal species, including wide application in domesticated animal production laboratories and reproductive toxicology. However, attempts to use CASA for human clinical semen analysis have largely met with poor success due to the inherent difficulties presented by many human semen samples caused by sperm clumping and heavy background debris that, until now, have precluded accurate digital image analysis. The authors review the improved capabilities of two modern CASA platforms (Hamilton Thorne CASA-II and Microptic SCA6) and consider their current and future applications with particular reference to directing our focus towards using this technology to assess functional rather than simple descriptive characteristics of spermatozoa. Specific requirements for validating CASA technology as a semi-automated system for human semen analysis are also provided, with particular reference to the accuracy and uncertainty of measurement expected of a robust medical laboratory test for implementation in clinical laboratories operating according to modern accreditation standards. PMID:25926614

  6. The future of computer-aided sperm analysis

    PubMed Central

    Mortimer, Sharon T; van der Horst, Gerhard; Mortimer, David

    2015-01-01

    Computer-aided sperm analysis (CASA) technology was developed in the late 1980s for analyzing sperm movement characteristics or kinematics and has been highly successful in enabling this field of research. CASA has also been used with great success for measuring semen characteristics such as sperm concentration and proportions of progressive motility in many animal species, including wide application in domesticated animal production laboratories and reproductive toxicology. However, attempts to use CASA for human clinical semen analysis have largely met with poor success due to the inherent difficulties presented by many human semen samples caused by sperm clumping and heavy background debris that, until now, have precluded accurate digital image analysis. The authors review the improved capabilities of two modern CASA platforms (Hamilton Thorne CASA-II and Microptic SCA6) and consider their current and future applications with particular reference to directing our focus towards using this technology to assess functional rather than simple descriptive characteristics of spermatozoa. Specific requirements for validating CASA technology as a semi-automated system for human semen analysis are also provided, with particular reference to the accuracy and uncertainty of measurement expected of a robust medical laboratory test for implementation in clinical laboratories operating according to modern accreditation standards. PMID:25926614

  7. [First-aid in France. Current situation and future perspectives].

    PubMed

    Larcan, Alain; Julien, Henri

    2010-06-01

    First-aid--treatment aimed at enabling a victim to survive pending the arrival of qualified medical support--is less well developed in France than in many other industrialized countries, especially among the general public. The current status of first-aid in France is paradoxical: schooling is free and obligatory, the ambulance service and emergency services are of the highest quality, but the general public are too often passive and unknowledgeable when faced with an emergency situation. This situation is due to several factors, including the complexity of first-aid training and regulations, the involvement of too many public bodies, the legal liability of the first-aider, and a lack of ongoing training. The French National Academy of Medicine recommends 8 measures to improve this situation: Provide a legal definition of first-aid: "a set of recognized measures aimed, in an emergency setting, at preserving the physical and psychological integrity of the victim of an accident or illness, notably pending the arrival of professional medical assistance". Waive, as in many other countries, civil and legal responsibility for the non professional first-aider, except in case of clear negligence. Reinforce the organization of first-aid in France in order to monitor the number and quality of first-aiders, and to ensure theoretical and pedagogic research; create a communications department capable of supporting and promoting first-aid. Improve access to first-aid training by increasing the number of situations in which it is obligatory (driving tuition, school and university examinations, group responsibility, at-risk practices), by providing financial assistance for certain groups, and by ensuring routine training at school, in the armed forces, and in the workplace. Create a progressive and integrated citizen first-aid training course with individual modules, ensuring that first-aiders update and perfect their knowledge throughout life. Soften pedagogic rules and shorten

  8. The Future of Research Communication

    PubMed Central

    Clark, Tim; De Waard, Anita; Herman, Ivan; Hovy, Eduard

    2015-01-01

    This report documents the program and the outcomes of Dagstuhl Perspectives Workshop 11331 “The Future of Research Communication”. The purpose of the workshop was to bring together researchers from these different disciplines, whose core research goal is changing the formats, standards, and means by which we communicate science. PMID:26317061

  9. The Future of Research Universities.

    ERIC Educational Resources Information Center

    Brooks, Norward J.

    It is proposed that research universities are a vital component of higher education in the United States because they provide cultural and intellectual leadership, research potential, and the professional and technical human resources to translate research into social, industrial, and economic action. The future of these institutions in view of…

  10. A Review of HIV/AIDS Research in Malaysia.

    PubMed

    Koh, K C

    2014-08-01

    Two hundred fifty seven articles related to HIV/AIDS were found in a search through a database dedicated to indexing all original data relevant to medicine published in Malaysia between the years 2000-2013. One hundred seventy one articles were selected and reviewed on the basis of clinical relevance and future research implications. This review of literature has been divided into six sections, namely, epidemiology, risk behaviour, clinical features and opportunistic infections, management, diagnosis and discussion. Wherever possible, the reviewed articles have been presented in a chronological order to provide a historical perspective to the reader as many of the results of earlier publications, which are common knowledge now, were relatively unknown then. Since the early days of the HIV epidemic in Malaysia, there have been rapid advances in the understanding and the management of the epidemic in Malaysia based on the insights derived from the results of these research. These insights are invaluable tools for policy makers, advocators, healthcare providers, researchers and everyone and anyone who are involved in the care of individuals with HIV/AIDS. Attempts have been made to identify gaps in certain research areas with the hope of providing directions for future research in HIV/AIDS in Malaysia. PMID:25417954

  11. Ground zero: AIDS research in Africa.

    PubMed

    Cohen, J

    2000-06-23

    More and more European and North American AIDS researchers are coming to sub-Saharan Africa, which is home to a whopping 70% of all HIV-infected people. These investigators are collaborating with local researchers on projects that aim to slow both HIV's spread and the course of disease in the millions already infected. But most African countries--constrained by limited resources, weak infrastructures, social mores, and political inaction--have grave difficulties translating research insights into prevention and treatment strategies. PMID:10896592

  12. HIV/AIDS and Employment Research: A Need for an Integrative Approach

    ERIC Educational Resources Information Center

    Conyers, Liza Marie

    2008-01-01

    This article provides a reflection on the three articles that compose the Major Contribution on HIV/AIDS and employment research. It highlights the merits of the contribution in the broader context of HIV/AIDS employment research and recommends future directions for this area of inquiry, including theory integration, an investigation of HIV health…

  13. AIDS Exceptionalism: On the Social Psychology of HIV Prevention Research.

    PubMed

    Fisher, William A; Kohut, Taylor; Fisher, Jeffrey D

    2009-12-01

    The current analysis considers the HIV prevention research record in the social sciences. We do so with special reference to what has been termed "AIDS Exceptionalism"- departures from standard public health practice and prevention research priorities in favor of alternative approaches to prevention that, it has been argued, emphasize individual rights at the expense of public health protection. In considering this issue, we review the historical context of the HIV epidemic; empirically demonstrate a pattern of prevention research characterized by systematic neglect of prevention interventions for HIV-infected persons; and articulate a rationale for "Prevention for Positives," supportive prevention efforts tailored to the needs of HIV+ individuals. We then propose a social psychological conceptualization of processes that appear to have influenced developments in HIV prevention research and directed its focus to particular target populations. Our concluding section considers whether there are social and research policy lessons to be learned from the record of HIV prevention research that might improve our ability to addresses effectively, equitably, and in timely fashion future epidemics that play out, as HIV does, at the junction of biology and behavior. At the first quarter century of the AIDS epidemic, it is important to weigh our accomplishments against our failures in the fight against AIDS…Future historians will conclude that we cannot escape responsibility for our failure to use effective, scientifically proven strategies to control the AIDS epidemic…They will also likely regard as tragic those instances when we allowed scarce resources to be used to support ideologically driven "prevention" that only served a particular political agenda.Editorial: A Quarter Century of AIDS. American Journal of Public Health. (Stall & Mills, 2006, p. 961). PMID:23667386

  14. AIDS Exceptionalism: On the Social Psychology of HIV Prevention Research

    PubMed Central

    Fisher, William A.; Kohut, Taylor; Fisher, Jeffrey D.

    2013-01-01

    The current analysis considers the HIV prevention research record in the social sciences. We do so with special reference to what has been termed “AIDS Exceptionalism”— departures from standard public health practice and prevention research priorities in favor of alternative approaches to prevention that, it has been argued, emphasize individual rights at the expense of public health protection. In considering this issue, we review the historical context of the HIV epidemic; empirically demonstrate a pattern of prevention research characterized by systematic neglect of prevention interventions for HIV-infected persons; and articulate a rationale for “Prevention for Positives,” supportive prevention efforts tailored to the needs of HIV+ individuals. We then propose a social psychological conceptualization of processes that appear to have influenced developments in HIV prevention research and directed its focus to particular target populations. Our concluding section considers whether there are social and research policy lessons to be learned from the record of HIV prevention research that might improve our ability to addresses effectively, equitably, and in timely fashion future epidemics that play out, as HIV does, at the junction of biology and behavior. At the first quarter century of the AIDS epidemic, it is important to weigh our accomplishments against our failures in the fight against AIDS…Future historians will conclude that we cannot escape responsibility for our failure to use effective, scientifically proven strategies to control the AIDS epidemic…They will also likely regard as tragic those instances when we allowed scarce resources to be used to support ideologically driven “prevention” that only served a particular political agenda. Editorial: A Quarter Century of AIDS. American Journal of Public Health. (Stall & Mills, 2006, p. 961) PMID:23667386

  15. The future of pediatric research.

    PubMed

    Boat, Thomas F

    2007-11-01

    The future of pediatric research will be enhanced by strengthening traditional biomedical approaches and embracing emerging opportunities. Biomedical discovery and translation of new knowledge, concepts, and devices into better diagnostic and therapeutic options will require more pediatric physician-scientists, rapid adoption of enabling technologies, increased funding for research and research training (including the creation of federally funded pediatric translational research centers), and a broader distribution of research activities across the academic pediatric community. Rapid improvement of child health outcomes also will be realized through robust health services research in pediatrics, including the application of rigorous quality improvement science that documents and disseminates successful interventions, leading to better access and effectiveness of care. Improving the value of pediatric care is a realistic goal. Achieving better outcomes through individually tailored (personalized) care for children should be tested experimentally. The future of pediatrics is bright, but will depend on the recognition of and response to a growing array of exciting opportunities. PMID:17950318

  16. A contextual approach to research on AIDS prevention.

    PubMed

    Wulfert, E; Biglan, A

    1994-01-01

    The acquired immune deficiency syndrome (AIDS) is a disease that is transmitted almost entirely through behavioral factors. In the absence of a cure or vaccine, the modification of AIDS-risk behavior presents a unique challenge to behavioral scientists and should be taken as a clear imperative by behavior analysts. This paper discusses the currently dominant social-cognitive theories (the health belief model, the theory of reasoned action, and self-efficacy theory) that have been widely used to predict and understand AIDS-risk behavior. Although these theories have generated a voluminous literature on the cognitive, attitudinal, and demographic correlates of AIDS-risk behavior, they have not resulted in specific intervention strategies to influence risky behavior, most likely because they fail to specify manipulable variables. As an alternative to social-cognitive theories, this paper evaluates the usefulness of a behavior-analytic approach to stem the spread of HIV infection. It examines some of the philosophical differences underlying cognitive and behavioral approaches that are embedded in mechanistic versus functional contextualistic principles. It explores the theoretical and practical implications of adopting either predicting and explaining behavior or predicting and influencing behavior as the goals of science. To illustrate the value of adopting the goal of prediction and influence, behavior-analytic research on the social context of risky sexual behavior in adolescents is described. The paper argues that in order to alter the future course of the AIDS epidemic, the behavioral sciences must move beyond describing cognitive and attitudinal correlates of risky behavior and focus on the social context of the behavior of individuals. In addition, population-wide changes in AIDS-risk behavior can be accomplished only if research focuses on how to influence larger social systems, including the media, school systems, and community organizations. PMID:22478197

  17. Research Needs and Future Directions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The food safety challenges facing the growers, processors and consumers of fresh and fresh cut produce are complex and multi-faceted. Established and ongoing research has given new insights into the ways in which produce can be contaminated at any step in the supply chain. The goal of future researc...

  18. Self-Fitting Hearing Aids: Status Quo and Future Predictions.

    PubMed

    Keidser, Gitte; Convery, Elizabeth

    2016-01-01

    A self-contained, self-fitting hearing aid (SFHA) is a device that enables the user to perform both threshold measurements leading to a prescribed hearing aid setting and fine-tuning, without the need for audiological support or access to other equipment. The SFHA has been proposed as a potential solution to address unmet hearing health care in developing countries and remote locations in the developed world and is considered a means to lower cost and increase uptake of hearing aids in developed countries. This article reviews the status of the SFHA and the evidence for its feasibility and challenges and predicts where it is heading. Devices that can be considered partly or fully self-fitting without audiological support were identified in the direct-to-consumer market. None of these devices are considered self-contained as they require access to other hardware such as a proprietary interface, computer, smartphone, or tablet for manipulation. While there is evidence that self-administered fitting processes can provide valid and reliable results, their success relies on user-friendly device designs and interfaces and easy-to-interpret instructions. Until these issues have been sufficiently addressed, optional assistance with the self-fitting process and on-going use of SFHAs is recommended. Affordability and a sustainable delivery system remain additional challenges for the SFHA in developing countries. Future predictions include a growth in self-fitting products, with most future SFHAs consisting of earpieces that connect wirelessly with a smartphone and providers offering assistance through a telehealth infrastructure, and the integration of SFHAs into the traditional hearing health-care model. PMID:27072929

  19. Radar signature generation for feature-aided tracking research

    NASA Astrophysics Data System (ADS)

    Piatt, Teri L.; Sherwood, John U.; Musick, Stanton H.

    2005-05-01

    Accurately associating sensor kinematic reports to known tracks, new tracks, or clutter is one of the greatest obstacles to effective track estimation. Feature-aiding is one technology that is emerging to address this problem, and it is expected that adding target features will aid report association by enhancing track accuracy and lengthening track life. The Sensor's Directorate of the Air Force Research Laboratory is sponsoring a challenge problem called Feature-Aided Tracking of Stop-move Objects (FATSO). The long-range goal of this research is to provide a full suite of public data and software to encourage researchers from government, industry, and academia to participate in radar-based feature-aided tracking research. The FATSO program is currently releasing a vehicle database coupled to a radar signature generator. The completed FATSO system will incorporate this database/generator into a Monte Carlo simulation environment for evaluating multiplatform/multitarget tracking scenarios. The currently released data and software contains the following: eight target models, including a tank, ammo hauler, and self-propelled artillery vehicles; and a radar signature generator capable of producing SAR and HRR signatures of all eight modeled targets in almost any configuration or articulation. In addition, the signature generator creates Z-buffer data, label map data, and radar cross-section prediction and allows the user to add noise to an image while varying sensor-target geometry (roll, pitch, yaw, squint). Future capabilities of this signature generator, such as scene models and EO signatures as well as details of the complete FATSO testbed, are outlined.

  20. Financial Aid Policy: Lessons from Research

    ERIC Educational Resources Information Center

    Dynarski, Susan; Scott-Clayton, Judith

    2013-01-01

    In the nearly fifty years since the adoption of the Higher Education Act of 1965, financial aid programs have grown in scale, expanded in scope, and multiplied in form. As a result, financial aid has become the norm among college enrollees. Aid now flows not only to traditional college students but also to part-time students, older students, and…

  1. The Nursing Research Center on HIV/AIDS Health Disparities.

    PubMed

    Holzemer, William L; Méndez, Marta Rivero; Portillo, Carmen; Padilla, Geraldine; Cuca, Yvette; Vargas-Molina, Ricardo L

    2004-01-01

    This report describes the partnership between the schools of nursing at the University of California San Francisco and the University of Puerto Rico to address the need for nursing research on HIV/AIDS health disparities. The partnership led to the creation of the Nursing Research Center on HIV/AIDS Health Disparities with funding from the National Institutes of Health/National Institute of Nursing Research. We provide background information on the disproportionate impact of the HIV/AIDS epidemic on racial and ethnic minorities, describe the major predictors of health disparities in persons at risk for or diagnosed with HIV/AIDS using the Outcomes Model for Health Care Research, and outline the major components of the Nursing Research Center. The center's goal is to improve health outcomes for people living with and affected by HIV/AIDS by enhancing the knowledge base for HIV/AIDS care. PMID:15499311

  2. Future directions in meteorite research

    NASA Technical Reports Server (NTRS)

    Anders, E.; Kerridge, John F.

    1988-01-01

    Information presently available on meteorite composition and history and the areas in meteorite research that should be covered in future in order to shed additional light on the earliest history of the solar system are discussed. Attention is given to the work needed in the classification schemes for chondrites, the question of the identification of parent bodies of the major meteorite and chondrite types, the igneous differentiation of certain asteroids, the effects of irradiation, the solar-system chronology, and issues concerning the early solar system. Other important areas discussed include the elemental composition of chondrites, the magnetic properties of meteorites, the composition and the petrology of chondrules, the properties of primitive material surviving in chondrites, the micrometeorites, the nebula, the presolar material in meteorites, the nucleosynthesis, and the nucleocosmochronology.

  3. Sensory Aids Research Project - Clarke School for the Deaf.

    ERIC Educational Resources Information Center

    Boothroyd, Arthur

    Described is a program of research into sensory aids for the deaf, emphasizing research on factors involved in the effective use of sensory aids rather than evaluation of particular devices. Aspects of the program are the development of a programed testing and training unit, the control of fundamental voice frequency using visual feedback, and…

  4. Barriers and aids in conducting research with older homeless individuals.

    PubMed

    Vance, D

    1995-06-01

    Field notes of a qualitative pilot study of older homeless people in Cincinnati identified several barriers and aids to the study of homeless elders. Identified research barriers were researcher's lack of contextual wisdom (street smarts), locating elders, substance abuse, attrition, victimization, credibility of informants, and xenophobia. Identified research aids were friendliness of certain elders, openness of the researcher, attractive incentives in exchange for interviews, and service providers' willingness to share experiences. PMID:7568590

  5. The Future of Financial Aid: Principles, Problems, Probable Outcomes.

    ERIC Educational Resources Information Center

    Johnstone, D. Bruce

    1986-01-01

    Forces threatening the fundamental principles and practices of student financial aid are examined, and some advice to the profession is offered. A large dedicated profession has emerged that is skilled at bringing together students, colleges, and resources. (MLW)

  6. Research and Demonstration for Nurse' Aide Training.

    ERIC Educational Resources Information Center

    Rast, Robert

    A cooperative pilot project was conducted to determine the feasibility of training mentally retarded individuals to function in a hospital setting. The 3-month nurse aide training program included 1 month of formal classroom training at the college and 2 months of supervised training in a hospital. A total of 51 students entered four classes over…

  7. An Interview with AIDS Vaccine Researcher Chris Parks

    ERIC Educational Resources Information Center

    Sullivan, Megan

    2010-01-01

    The search for an AIDS (acquired immune deficiency syndrome) vaccine is truly a global effort, with university laboratories, biotech firms, pharmaceutical companies, nonprofit research organizations, hospitals, and clinics all working together to develop an effective vaccine as quickly as possible. The International AIDS Vaccine Initiative (IAVI)…

  8. Future Directions: HIV/AIDS Education in the Nation's Schools.

    ERIC Educational Resources Information Center

    Sex Information and Education Council of the United States, Inc., New York, NY.

    While states have developed the infrastructure to support effective education programs on Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), inadequacies exist in the content of curricula, guidelines, and program design. Many state programs fail to provide children with all the information they need in order to avoid and…

  9. Research Training--Present & Future.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    In 10 papers by independent experts, this volume explores the trends in and prospects for research training in member nations of the Organization for Economic Cooperation and Development. "Problems and Prospects of Research Training in the 1990s" (Stuart Blume) looks at trends in national policy toward research training and issues of quality.…

  10. Animal models for HIV/AIDS research

    PubMed Central

    Hatziioannou, Theodora; Evans, David T.

    2015-01-01

    The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection. PMID:23154262

  11. U.S. to aid coastal research

    NASA Astrophysics Data System (ADS)

    Katsouros, Mary Hope

    Prior to the 1964 implementation of the 1958 Convention on the Continental Shelf, oceanographers were free to plan and carry out research projects virtually anywhere on or under the seas of the world (see Article 5(1) and 5(8)). Today, dozens of coastal nations regulate marine research within 200 nautical miles (370 km) of their shores, imposing increasingly severe restrictions and creating diverse and uncertain consent procedures. Both the Reagan administration and Congress have acted recently to alleviate some of these jurisdictional problems being experienced by U.S. marine scientists.On March 10, 1983, President Reagan issued a proclamation on the “Exclusive Economic Zone of the United States of America” and related statements. It is the accompanying “Statement by the President” and the “Fact Sheet” on “United States Oceans Policy” (all three of which are dated March 10), rather than the proclamation, that outline the U.S. position on the conduct of marine scientific research. The “Statement by the President” declares that, While international law provides for a right of jurisdiction over marine scientific research within such a zone, the proclamation does not assert this right. I have elected not to do so because of the United States' interest in encouraging marine scientific research and avoiding any unnecessary burdens. The United States will nevertheless recognize the right of other coastal states to exercise jurisdiction over marine scientific research within 200 nautical miles of their coasts, if that jurisdiction is exercised reasonably in a manner consistent with international law. The “Fact Sheet” states that, The President has decided not to assert jurisdiction over marine scientific research in the United States EEZ [Exclusive Economic Zone]. This is consistent with U.S. interest in promoting maximum freedom for such research. The Department of State will take steps to facilitate access by U.S. scientists to foreign EEZ

  12. Future methods in pharmacy practice research.

    PubMed

    Almarsdottir, A B; Babar, Z U D

    2016-06-01

    This article describes the current and future practice of pharmacy scenario underpinning and guiding this research and then suggests future directions and strategies for such research. First, it sets the scene by discussing the key drivers which could influence the change in pharmacy practice research. These are demographics, technology and professional standards. Second, deriving from this, it seeks to predict and forecast the future shifts in use of methodologies. Third, new research areas and availability of data impacting on future methods are discussed. These include the impact of aging information technology users on healthcare, understanding and responding to cultural and social disparities, implementing multidisciplinary initiatives to improve health care, medicines optimization and predictive risk analysis, and pharmacy as business and health care institution. Finally, implications of the trends for pharmacy practice research methods are discussed. PMID:27209486

  13. An appraisal of future space biomedical research

    NASA Technical Reports Server (NTRS)

    Vinograd, S. P.

    1975-01-01

    Three general classes of manned space flight missions of the future are described. These include: earth-orbital, lunar, and planetary. Biomedical science and technology is analyzed emphasizing areas of research needed to support future manned space flights and the information to be obtained from them.

  14. Future directions for agricultural phosphorus research

    SciTech Connect

    Sikora, F.J.

    1992-03-01

    Future Directions for Agricultural Phosphorus Research is a collection of papers presented at a workshop in Muscle Shoals, Alabama, on July 18 and 19, 1990. The objective of the workshop was to gather representatives of academia, government, and industry to discuss and debate research needs with phosphorus in agriculture, ranging from basic to applied research. The enclosed papers present information on current knowledge in the areas of (1) identifying phosphorus solid phases in soil, (ii) enhanced phosphorus bioavailability through microbial activity, (iii) phosphorus rock quality, (iv) environmental issues regarding phosphorus in agriculture, (v) predicting phosphorus bioavailability in soil, and (vi) fertilizer management effects on phosphorus availability. Within each paper, the authors suggest future research needs in their area. With the discussion of current knowledge and future research needs, this publication was designed to benefit organizations formulating and developing research plans concerning phosphorus in agricultural systems.

  15. A Future of Satellite-Aided Search and Rescue

    NASA Technical Reports Server (NTRS)

    Wallace, Ronald

    1998-01-01

    Satellite technology has been an integral part of maritime search and rescue since the Cospas-Sarsat system began operation in 1984. This system, credited with more than eighty-six hundred lives saved, has recently been augmented to provide immediate response through geostationary satellites. The other satellite-based distress alerting system, INMARSAT, launched its emergency Standard C service in 1991 and Standard E in 1997. Current plans call for a continuation of service from both of these vital systems at least through the first decade of the next century. We are currently witnessing the construction of a number of new satellite systems that will have the potential for revolutionizing mobile communications. These systems will be capable of emergency communication, and must be given due consideration in any look at the future, This paper reviews existing systems using satellites for distress alerting, describes the plans in place for them, and discusses likely developments.

  16. AFB's Computerized Travel Aid: Two Years of Research and Development.

    ERIC Educational Resources Information Center

    Uslan, Mark M.; And Others

    1983-01-01

    Progress on the computerized travel aid, an electronic device, using elements of the Polaroid Sonar Camera and a microprocessor, for visually handicapped persons is reviewed, and research on the effectiveness of various models noted. Recommended modifications touch on aspects of mounting, beam shape, and audible outputs. (CL)

  17. Confronting AIDS. Directions for Public Health, Health Care, and Research.

    ERIC Educational Resources Information Center

    Institute of Medicine (NAS), Washington, DC.

    This book is addressed to anyone involved with or affected by the Acquired Immune Deficiency Syndrome (AIDS) epidemic, including legislators, researchers, health care personnel, insurance providers, educators, health officials, executives in the pharmaceutical industry, blood bank administrators, and other concerned individuals. The following…

  18. Recommendations for future research in hypersonic instrumentation

    NASA Technical Reports Server (NTRS)

    Ocheltree, S. L.

    1993-01-01

    An overview of the NATO Advanced Research Workshop is presented. It describes the process followed to obtain a group consensus on the main technical recommendations for each of the five technical sessions of the Workshop and presents the general conclusions and recommendations for future research agreed upon by the workshop participants.

  19. Future Perspectives of Biocybernetic Research in Television.

    ERIC Educational Resources Information Center

    Malik, M. F.; Thwaites, H. M.

    This paper describes the future perspectives of biocybernetic communication research applied to television, i.e., the measurement of the information impact of television on both individual human beings and groups in terms of energetic changes in the human body. A summary of the recent state of the art of biocybernetic research includes discussions…

  20. Future of federal research and development

    SciTech Connect

    Goldman, D.T.

    1995-12-31

    This paper very briefly describes factors affecting federal funding for research and development. Historical, political, and economic aspects of funding are outlined. Projections of future funding is provided in general terms. The potential of the national laboratories for continued research and development contributions is described.

  1. AIDS action-research with women in Kinshasa, Zaire.

    PubMed

    Schoepf, B G

    1993-12-01

    AIDS has assumed epidemic proportions in Central Africa. Knowledge of culturally constructed gender relations and sexual meanings is crucial to developing prevention strategies and reducing the impact of AIDS. CONNAISSIDA, a transdisciplinary medical anthropology research project, developed culturally appropriate community-based empowerment workshops. These used cognitive, emotional and social stimulants to provoke critical reflection and action. Collaborative relationships developed in workshops were used to study sexual relations in many contexts. Significant changes in knowledge and action were observed. Nevertheless, economic necessity and inequality limited the ability of many women to avoid sexual risk. Economic crisis, structural adjustment and debt reimbursement policies have exacerbated poverty, particularly among women. Linking macrolevel political economy to microlevel sociocultural analysis shows how strategies adopted for survival contribute to sexual risk. Therefore broader socioeconomic changes that reduce poverty and gender subordination are necessary to control the HIV/AIDS epidemic. Findings from Zaire are widely applicable in the region. PMID:8284707

  2. Current ethical issues in HIV/AIDS research and HIV/AIDS care.

    PubMed

    Hlongwa, P

    2016-04-01

    HIV/AIDS is a global public health concern with more than 30 million deaths having been reported. Over 70% of the 35 million people with HIV/AIDS live in sub-Saharan Africa. The current available antiretroviral treatments are limited because they do not cure but slow the progression of disease. Therefore, care and treatment for HIV/AIDS and its related research, especially in HIV-preventive vaccine trials, require stringent ethical guidelines because of the vulnerability of the affected individuals as it with all clinical trials. These guidelines should incorporate the basic principles in ethics which include autonomy of individuals, beneficence, non-malfeasance and justice in the care and participation of individuals in research. With at least one in five African adults infected with the disease living in sub-Saharan Africa, this review will discuss the current ethical issues in HIV care and HIV research based on the South African context as well as exploring some of the issues globally. PMID:27109274

  3. The impact of HIV and AIDS research: a case study from Swaziland

    PubMed Central

    2011-01-01

    Background Swaziland is experiencing the world’s worst HIV and AIDS epidemic. Prevalence rose from four percent of antenatal clinic attendees in 1992 to 42.6 percent in 2004. The Report ‘Reviewing ‘Emergencies’ for Swaziland: Shifting the Paradigm in a New Era’ published in 2007 bought together social and economic indicators. It built a picture of the epidemic as a humanitarian emergency, requiring urgent action from international organisations, donors, and governments. Following a targeted communications effort, the report was believed to have raised the profile of the issue and Swaziland - a success story for HIV and AIDS research. Methods Keen to understand how, where and why the report had an impact, Health Economics and HIV/AIDS Research Division commissioned an assessment to track and evaluate the influence of the research. This tapped into literature on the significance of understanding the research-to-policy interface. This paper outlines the report and its impact. It explores key findings from the assessment and suggests lessons for future research projects. Results The paper demonstrates that, although complex, and not without methodological issues, impact assessment of research can be of real value to researchers in understanding the research-to-policy interface. Conclusion Only by gaining insight into this process can researchers move forward in delivering effective research. PMID:21679390

  4. Social ecological factors associated with future orientation of children affected by parental HIV infection and AIDS.

    PubMed

    Lin, Xiuyun; Fang, Xiaoyi; Chi, Peilian; Heath, Melissa Allen; Li, Xiaoming; Chen, Wenrui

    2016-07-01

    From a social ecological perspective, this study examined the effects of stigma (societal level), trusting relationships with current caregivers (familial level), and self-esteem (individual level) on future orientation of children affected by HIV infection and AIDS. Comparing self-report data from 1221 children affected by parental HIV infection and AIDS and 404 unaffected children, affected children reported greater stigma and lower future orientation, trusting relationships, and self-esteem. Based on structural equation modeling, stigma experiences, trusting relationships, and self-esteem had direct effects on future orientation, with self-esteem and trusting relationships partially mediating the effect of stigma experiences on children's future orientation. Implications are discussed. PMID:25370572

  5. The Medical Research Council (UK)/Uganda Virus Research Institute Uganda Research Unit on AIDS – ‘25 years of research through partnerships’

    PubMed Central

    Kaleebu, P; Kamali, A; Seeley, J; Elliott, A M; Katongole-Mbidde, E

    2015-01-01

    For the past 25 years, the Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS has conducted research on HIV-1, coinfections and, more recently, on non-communicable diseases. Working with various partners, the research findings of the Unit have contributed to the understanding and control of the HIV epidemic both in Uganda and globally, and informed the future development of biomedical HIV interventions, health policy and practice. In this report, as we celebrate our silver jubilee, we describe some of these achievements and the Unit's multidisciplinary approach to research. We also discuss the future direction of the Unit; an exemplar of a partnership that has been largely funded from the north but led in the south. PMID:25354929

  6. Future Earth - Research for Global Sustainability

    NASA Astrophysics Data System (ADS)

    Greenslade, Diana; Berkhout, Frans

    2014-05-01

    Future Earth is a 10-year international research programme that aims to provide the critical knowledge required for societies to understand and address challenges posed by global environmental change (GEC) and to seize opportunities for transitions to global sustainability. Future Earth research is organised around three broad and integrated research themes: Dynamic Planet; Global Development; and Transformations towards Sustainability. It builds upon and integrates the existing GEC Programmes: World Climate Research Programme (WCRP), the International Geosphere-Biosphere Programme (IGBP), DIVERSITAS (international programme of biodiversity science), the International Human Dimensions Programme (IHDP) and the Earth Systems Science Partnership (ESSP). This presentation will outline the key principles of Future Earth, such as the integration of natural and social science, and will describe how the programme intends to address the challenges of global environmental change. Some of the major research questions addressed by Future Earth could include: further understanding of the dynamics of the Earth system (including socio-ecology); risks relating to tipping points; how to ensure sustainable access to food, water and energy; and whether the present economic system provides the necessary framework for low carbon transition.

  7. HIV/AIDS Research in Correctional Settings: Perspectives on Training Needs from Researchers and IRB Members

    PubMed Central

    Kondo, Karli K.; Johnson, Mark E.; Ironside, Erica F.; Brems, Christiane; Eldridge, Gloria D.

    2015-01-01

    Being disproportionately represented by individuals living with HIV/AIDS, correctional facilities are an important venue for potentially invaluable HIV/AIDS epidemiological and intervention research. However, unique ethical, regulatory, and environmental challenges exist in these settings that have limited the amount and scope of research. We surveyed 760 HIV/AIDS researchers, and IRB chairs, members, and prisoner representatives to identify areas in which additional training might ameliorate these challenges. Most commonly identified training needs related to federal regulations, ethics (confidentiality, protection for participants/researchers, coercion, privacy, informed consent, and general ethics), and issues specific to the environment (culture of the correctional setting; general knowledge of correctional systems; and correctional environments, policies, and procedures). Bolstering availability of training on the challenges of conducting HIV/AIDS research in correctional settings is a crucial step toward increasing research that will yield significant benefits to incarcerated individuals and society as a whole. PMID:25490736

  8. Research and policy agendas: an AIDS world adrift?

    PubMed

    Ronald, A

    1992-01-01

    This editorial lists several questions prompted by the Eighth International Conference on AIDS in Amsterdam in 1992. The writer wonders whether it is time to proceed with interventions rather than blame bureaucracies for endless research. He asks if research should explore a sociocultural basis for lack of individual responsibility in curbing the epidemic. He deplores the waste of 4-70% of funds in Western programs. The possibility that traditional practitioners could be effective in AIDS prevention or care is raised. Similarly religious and nongovernmental organizations could play a larger role if they were recognized. Ways for the primary health care system to be better managed, better funded, and better equipped with appropriate technology must be found. The effectiveness of male circumcision to prevent HIV transmission must be addressed. The efficiency of communication by means of expert committees, scientific journals, and conferences is questioned. PMID:12286017

  9. Past, Present and Future in Interdisciplinary Research

    ERIC Educational Resources Information Center

    Gusdorf, Georges

    1977-01-01

    Presents examples of interdisciplinary research since the origin of western science and predicts that future interdisciplinary approaches to epistemological writing will take into account divergent thinking patterns and thereby end the domination by western intellectual imperialism. For journal availability, see SO 506 201. (Author/DB)

  10. NASA Lewis Research Center Futuring Workshop

    NASA Technical Reports Server (NTRS)

    Boroush, Mark; Stover, John; Thomas, Charles

    1987-01-01

    On October 21 and 22, 1986, the Futures Group ran a two-day Futuring Workshop on the premises of NASA Lewis Research Center. The workshop had four main goals: to acquaint participants with the general history of technology forecasting; to familiarize participants with the range of forecasting methodologies; to acquaint participants with the range of applicability, strengths, and limitations of each method; and to offer participants some hands-on experience by working through both judgmental and quantitative case studies. Among the topics addressed during this workshop were: information sources; judgmental techniques; quantitative techniques; merger of judgment with quantitative measurement; data collection methods; and dealing with uncertainty.

  11. Basic research for future electric propulsion

    NASA Technical Reports Server (NTRS)

    Jahn, R. G.

    1985-01-01

    It is pointed out that the evolution of electric propulsion over the past two and a half decades has been constrained by the interaction of three broad factors, including the physics and dynamics of the propellants, the dynamical and logistical requirements of the mission, and the technological realities of materials, power sources, and thermal management. A projection of the future of electric propulsion requires, therefore, a simultaneous reassessment of all three factors. Aspects of mission specification and power systems are discussed, and basic research needed for future electric propulsion applications is considered. Attention is given to electrostatic propulsion, electrothermal propulsion, electromagnetic propulsion, electrothermal/electromagnetic hybrids, novel concepts, and ancillary concerns.

  12. A programmable sound processor for advanced hearing aid research.

    PubMed

    McDermott, H

    1998-03-01

    A portable sound processor has been developed to facilitate research on advanced hearing aids. Because it is based on a digital signal processing integrated circuit (Motorola DSP56001), it can readily be programmed to execute novel algorithms. Furthermore, the parameters of these algorithms can be adjusted quickly and easily to suit the specific hearing characteristics of users. In the processor, microphone signals are digitized to a precision of 12 bits at a sampling rate of approximately 12 kHz for input to the DSP device. Subsequently, processed samples are delivered to the earphone by a novel, fully-digital class-D driver. This driver provides the advantages of a conventional class-D amplifier (high maximum output, low power consumption, low distortion) without some of the disadvantages (such as the need for precise analog circuitry). In addition, a cochlear implant driver is provided so that the processor is suitable for hearing-impaired people who use an implant and an acoustic hearing aid together. To reduce the computational demands on the DSP device, and therefore the power consumption, a running spectral analysis of incoming signals is provided by a custom-designed switched-capacitor integrated circuit incorporating 20 bandpass filters. The complete processor is pocket-sized and powered by batteries. An example is described of its use in providing frequency-shaped amplification for aid users with severe hearing impairment. Speech perception tests confirmed that the processor performed significantly better than the subjects' own hearing aids, probably because the digital filter provided a frequency response generally closer to the optimum for each user than the simpler analog aids. PMID:9535523

  13. Hispanic Behavioral Science Research: Recommendations for Future Research.

    ERIC Educational Resources Information Center

    Padilla, Amado M.; Lindholm, Kathryn J.

    1984-01-01

    Presents major developments in Hispanic behavioral science research over the past decade, and provides recommendations for future research, organized into three broad categories: life span issues (childhood, adolescence, adulthood, and elderly, all including some education-related issues), delivery of mental health services, and prevention and…

  14. Future fundamental combustion research for aeropropulsion systems

    NASA Technical Reports Server (NTRS)

    Mularz, E. J.

    1985-01-01

    Physical fluid mechanics, heat transfer, and chemical kinetic processes which occur in the combustion chamber of aeropropulsion systems were investigated. With the component requirements becoming more severe for future engines, the current design methodology needs the new tools to obtain the optimum configuration in a reasonable design and development cycle. Research efforts in the last few years were encouraging but to achieve these benefits research is required into the fundamental aerothermodynamic processes of combustion. It is recommended that research continues in the areas of flame stabilization, combustor aerodynamics, heat transfer, multiphase flow and atomization, turbulent reacting flows, and chemical kinetics. Associated with each of these engineering sciences is the need for research into computational methods to accurately describe and predict these complex physical processes. Research needs in each of these areas are highlighted.

  15. Future research in weight bias: What next?

    PubMed

    Alberga, Angela S; Russell-Mayhew, Shelly; von Ranson, Kristin M; McLaren, Lindsay; Ramos Salas, Ximena; Sharma, Arya M

    2016-06-01

    The 2015 Canadian Weight Bias Summit disseminated the newest research advances and brought together 40 experts, stakeholders, and policy makers in various disciplines in health, education, and public policy to identify future research directions in weight bias. In this paper we aim to share the results of the Summit as well as encourage international and interdisciplinary research collaborations in weight bias reduction. Consensus emerged on six research areas that warrant further investigation in weight bias: costs, causes, measurement, qualitative research and lived experience, interventions, and learning from other models of discrimination. These discussions highlighted three key lessons that were informed by the Summit, namely: language matters, the voices of people living with obesity should be incorporated, and interdisciplinary stakeholders should be included. PMID:27129601

  16. Futures Challenges in Thyroid Hormone Signaling Research

    PubMed Central

    Flamant, Frédéric

    2016-01-01

    The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research. PMID:27445973

  17. Futures Challenges in Thyroid Hormone Signaling Research.

    PubMed

    Flamant, Frédéric

    2016-01-01

    The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research. PMID:27445973

  18. A research agenda for AIDS prevention in the developing world.

    PubMed

    Hearst, N; Mandel, J S

    1997-09-01

    In the developing world, HIV is spreading in many different epidemiologic patterns. The spread may be slow among a few population groups, exponential, or at the level of a mature epidemic. HIV is spreading across a wide range of cultures and behavior patterns. A need therefore exists to tailor prevention measures to conditions and needs at local levels. Research at the local level is needed to guide the development and implementation of appropriate HIV prevention programs. The authors propose a research agenda for AIDS prevention in the developing world which consists of the following central components: epidemiologic and behavioral surveillance, improving the local understanding of HIV risk behavior, and testing interventions. Examples of each component are reviewed. In addition, bottom-up research is contrasted with top-down research conducted in the developing world by scientists from developed countries. PMID:9376092

  19. Computer-aided diagnosis in radiological imaging: current status and future challenges

    NASA Astrophysics Data System (ADS)

    Doi, Kunio

    2009-10-01

    Computer-aided diagnosis (CAD) has become one of the major research subjects in medical imaging and diagnostic radiology. Many different types of CAD schemes are being developed for detection and/or characterization of various lesions in medical imaging, including conventional projection radiography, CT, MRI, and ultrasound imaging. Commercial systems for detection of breast lesions on mammograms have been developed and have received FDA approval for clinical use. CAD may be defined as a diagnosis made by a physician who takes into account the computer output as a "second opinion". The purpose of CAD is to improve the quality and productivity of physicians in their interpretation of radiologic images. The quality of their work can be improved in terms of the accuracy and consistency of their radiologic diagnoses. In addition, the productivity of radiologists is expected to be improved by a reduction in the time required for their image readings. The computer output is derived from quantitative analysis of radiologic images by use of various methods and techniques in computer vision, artificial intelligence, and artificial neural networks (ANNs). The computer output may indicate a number of important parameters, for example, the locations of potential lesions such as lung cancer and breast cancer, the likelihood of malignancy of detected lesions, and the likelihood of various diseases based on differential diagnosis in a given image and clinical parameters. In this review article, the basic concept of CAD is first defined, and the current status of CAD research is then described. In addition, the potential of CAD in the future is discussed and predicted.

  20. The Future of Nearshore Processes Research

    NASA Astrophysics Data System (ADS)

    Elko, N.; Feddersen, F.; Foster, D. L.; Holman, R. A.; McNinch, J.; Ozkan-Haller, H. T.; Plant, N. G.; Raubenheimer, B.; Elgar, S.; Hay, A. E.; Holland, K. T.; Kirby, J. T., Jr.; Lippmann, T. C.; Miller, J. K.; Stockdon, H. F.; Ashton, A. D.; Boehm, A. B.; Clark, D.; Cowen, E.; Dalyander, S.; Gelfenbaum, G. R.; Hapke, C. J.; MacMahan, J.; McNamara, D.; Mulligan, R. P.; Palmsten, M. L.; Ruggiero, P.; Sherwood, C. R.; Hsu, T. J.

    2014-12-01

    Over 70 members of the nearshore coastal processes research community convened in April 2014 to discuss a vision for the future of nearshore science while celebrating the memories and contributions of our recently departed colleague, Abby Sallenger. The participants reviewed community accomplishments over the past four decades. Federal agencies, including FEMA, NOAA, NPS, USGS, USACE, and NRL discussed the most pressing societal needs within the coastal zone. The group engaged in a retrospective of the last four decades of progress, assessed the current status and limitations of nearshore processes research, and developed a vision for the future that focuses on societally relevant problems. The top research topics identified included: Long-term Coastal Impacts: Meaningfully improve our understanding and prediction of the long-term coastal effects of sea level rise and changes in storminess patterns and associated efforts to protect coastal infrastructure. Extreme Events: Coastal flooding, overland flow, and concurrent morphological evolution during extreme events including the subsequent process of coastal recovery. Human and Ecosystem Health: Linkages between physical coastal processes (transport and mixing) and land-based pollution (pathogens, nutrients, toxic contaminants). Critical for addressing these research questions is enabling infrastructure, such as new observational tools and data sets, models, and nearshore-community communication and collaboration. Idea and concepts developed during the meeting (to be published in Shore and Beach) will be presented to foster collaboration and advocacy amongst the wider nearshore community. Meeting materials are available at: https://scripps.ucsd.edu/centers/nearshorefuture/.

  1. Student Aid Handbook, 1998-1999: Journey to a Successful Future...

    ERIC Educational Resources Information Center

    Alaska State Commission on Postsecondary Education, Juneau.

    This Student Aid Handbook presents suggestions for prospective applicants to consider when choosing a college or university which bet meets the candidate's needs and goals. The Handbook describes four areas to consider and related questions when researching a field of study or school: national accreditation or state authorizations, courses, costs,…

  2. Research Donor Program Needs Your Help to Advance Cancer and AIDS Research | Poster

    Cancer.gov

    NCI at Frederick employees have a unique opportunity to contribute directly to cancer and AIDS research by donating blood, saliva, and other samples through the Research Donor Program (RDP). Donors are compensated for their time, which is typically between 10 and 30 minutes. The RDP, which is administered by Occupational Health Services (OHS), Leidos Biomedical Research, provides samples from healthy donors for use in in vitro research conducted at NCI at Frederick and Fort Detrick. Samples are provided anonymously to researchers.

  3. Wound ballistics: contemporary and future research.

    PubMed

    Ryan, J M; Cooper, G J; Maynard, R L

    1988-10-01

    Wound ballistics research has contributed much to the understanding of the pathophysiology of missile injury that now exists. From this store of knowledge treatment regimes have evolved which have greatly improved the lot of the soldier wounded in war. However, research must keep pace with changes that are taking place in weapons research and development so that the particular needs of the Army Medical Services on a future battlefield can be met. The differing needs of civilian and military medical services are highlighted. The marked differences that exist between the missile wound seen and treated in a late twentieth century hospital and the wounds likely to be encountered on the modern battlefield are enumerated and discussed. PMID:3057188

  4. Future directions in preterm birth research.

    PubMed

    Jain, Joses; Gyamfi-Bannerman, Cynthia

    2016-04-01

    The problem of preterm birth continues to pose one of the most significant research challenges that we face due to its immense scope and complexity. With evidence that 95% of cases of spontaneous preterm birth are intractable to current interventions, our best hope in resolving this problem may lie in new, innovative ideas. Novel approaches to researching preterm birth are currently underway, building upon our prior discoveries and probing into the unknown on multiple fronts. Here we discuss some of the major focuses of future investigation that provide a promising outlook for discovery, including advanced techniques to evaluate the cervix, new strategies to identify the role of the microbiome, and advances in molecular and epigenetic-based research. PMID:26640166

  5. Virtually Shaping the Future of Polar Research

    NASA Astrophysics Data System (ADS)

    Baeseman, J. L.; Koldunov, N. V.; Jochum, K.

    2009-12-01

    The Association of Polar Early Career Scientists (APECS) is an international and interdisciplinary organization for undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the wider cryosphere that started as a result of the International Polar Year (IPY). APECS is leading the way for virtual communication of polar research through several activities: an online Polar Literature Discussion Forum, a Virtual Poster Session, and Communication beyond the conference setting. APECS has created an extensive online discussion forum where researchers share both classic and cutting-edge literature articles and critique techniques that were used by authors, helping to improve methods as well as discover new ways to approach polar research questions. Many researchers present their results as posters at conferences. APECS has taken this process to a new level by creating a format to display previously presented posters online instead of these files simply sitting on a researcher’s hard-drive. Not only are the posters online, a monthly conference call open to hundreds of participants allows researchers to share their work with a new audience - fellow researchers, community members, potential colleagues, policy makers and educators. These calls are recorded and archived online so the next time someone visits the poster, they can hear the researcher describe their work and communicate with the researcher questions they may have, potential ways to collaborate or share different methodologies to improve future endeavors. Peer-reviewed literature articles are the currency of science and APECS has capitalized on this by creating a way for researchers to increase the exposure of their publications beyond the table of contents published by journals. The Polar Literature Discussion Forum is a new way for researchers to share their papers, as well as discuss classic articles. This has become a popular

  6. HIV/AIDS Researchers Interaction with Schoolteachers: A Key to Combat AIDS among Brazilian Adolescents

    ERIC Educational Resources Information Center

    Kashima, Simone; de Castro, Fabiola Attie; de Castro Amarante, Maria Fernanda; Barbieri, Marisa Ramos; Covas, Dimas Tadeu

    2008-01-01

    Considering the fact that information on HIV/AIDS is a strategy for disease control, this project was planned to provide comprehensive information about HIV infection and AIDS to schoolteachers and their students. Previous analysis of adolescent students' knowledge of HIV/AIDS showed that they still have doubts about transmission, diagnosis, and…

  7. Recruiting Chinese American adolescents to HIV/AIDS-related research: a lesson learned from a cross-sectional study.

    PubMed

    Lee, Yi-Hui; Salman, Ali; Wang, Fan

    2012-02-01

    The purpose of this article was to report identified barriers and challenges experienced in the recruiting process of Chinese American adolescents to a cross-sectional HIV/AIDS-related study. Snowball sampling method was used to recruit Chinese American adolescents from Chinese American communities in a U.S. Midwestern state. Barriers and challenges to recruitment were reviewed and analyzed from Chinese cultural perspectives in the hope of aiding researchers and health care providers understand and facilitate future recruitment of Chinese Americans for HIV/AIDS prevention studies. Barriers to recruitment were found related to the taboo topic of sexual issues in Chinese culture, unawareness and denial of HIV/AIDS risks, authoritarian parenting style in Chinese culture, and the required active consents. Facilitating factors of recruiting Chinese American adolescents to future HIV/AIDS prevention research or intervention programs are discussed. Information provided in this article may increase nurses' awareness of various barriers that they might encounter when they conduct research or address HIV/AIDS-related topics of Chinese American adolescents. PMID:20974090

  8. Strengthening capacity for AIDS vaccine research: analysis of the Pfizer Global Health Fellows Program and the International AIDS Vaccine Initiative

    PubMed Central

    2013-01-01

    Background Industry partnerships can help leverage resources to advance HIV/AIDS vaccine research, service delivery, and policy advocacy goals. This often involves capacity building for international and local non-governmental organizations (NGOs). International volunteering is increasingly being used as a capacity building strategy, yet little is known about how corporate volunteers help to improve performance of NGOs in the fight against HIV/AIDS. Methods This case study helps to extend our understanding by analyzing how the Pfizer Global Health Fellows (GHF) program helped develop capacity of the International AIDS Vaccine Initiative (IAVI), looking specifically at Fellowship activities in South Africa, Kenya, and Uganda. From 2005–2009, 8 Pfizer GHF worked with IAVI and local research centers to strengthen capacity to conduct and monitor vaccine trials to meet international standards and expand trial activities. Data collection for the case study included review of Fellow job descriptions, online journals, evaluation reports, and interviews with Fellows and IAVI staff. Qualitative methods were used to analyze factors which influenced the process and outcomes of capacity strengthening. Results Fellows filled critical short-term expert staffing needs at IAVI as well as providing technical assistance and staff development activities. Capacity building included assistance in establishing operating procedures for the start-up period of research centers; training staff in Good Clinical Practice (GCP); developing monitoring capacity (staff and systems) to assure that centers are audit-ready at all times; and strategic planning for data management systems. Factors key to the success of volunteering partnerships included similarities in mission between the corporate and NGO partners, expertise and experience of Fellows, and attitudes of partner organization staff. Conclusion By developing standard operating procedures, ensuring that monitoring and regulatory

  9. Financial issues in defining levels for HIV/AIDS research.

    PubMed

    Eastaugh, S R

    1998-01-01

    This article outlines the issues in cost identification and fair payment for acquired immune deficiency syndrome (AIDS) research. Costs need to be better identified using activity-based costing methods to reveal the structural pattern of care. Patterns of care can be too expensive if they: (1) overutilize the hospital as the locus of care, or (2) underutilize prevention and education. Managers need to learn more about the cost identification issues payers face in designing a fair payment system. In the long run, more health care professionals would serve the cause of innovation and biomedical research if they all work together to define a stable fair funding mechanism. Payers need to learn that fair payment of indirect costs is not a bonus or a windfall profit. PMID:9718508

  10. Defining Future Directions for Endometriosis Research

    PubMed Central

    D’Hooghe, Thomas M.; Fazleabas, Asgerally; Giudice, Linda C.; Montgomery, Grant W.; Petraglia, Felice; Taylor, Robert N.

    2013-01-01

    Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008.1 A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis. PMID:23427182

  11. The Nation's Top HIV/AIDS Researcher Discusses This Continuing Health Threat

    MedlinePlus

    ... Navigation Bar Home Current Issue Past Issues HIV / AIDS The Nation's Top HIV/AIDS Researcher Discusses This Continuing Health Threat Past Issues / ... For more than 30 years, the NIH's HIV/AIDS research program has been led by Dr. Anthony S. ...

  12. Research Domain Criteria: toward future psychiatric nosologies

    PubMed Central

    Cuthbert, Bruce N.

    2015-01-01

    The Research Domain Criteria (RDoC) project was initiated by the National Institute of Mental Health (NIMH) in early 2009 as the implementation of Goal 1.4 of its just-issued strategic plan. In keeping with the NIMH mission, to “transform the understanding and treatment of mental illnesses through basic and clinical research,” RDoC was explicitly conceived as a research-related initiative. The statement of the relevant goal in the strategic plan reads: “Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.” Due to the novel approach that RDoC takes to conceptualizing and studying mental disorders, it has received widespread attention, well beyond the borders of the immediate research community. This review discusses the rationale for the experimental framework that RDoC has adopted, and its implications for the nosology of mental disorders in the future. PMID:25987867

  13. Signal Processing in High-End Hearing Aids: State of the Art, Challenges, and Future Trends

    NASA Astrophysics Data System (ADS)

    Hamacher, V.; Chalupper, J.; Eggers, J.; Fischer, E.; Kornagel, U.; Puder, H.; Rass, U.

    2005-12-01

    The development of hearing aids incorporates two aspects, namely, the audiological and the technical point of view. The former focuses on items like the recruitment phenomenon, the speech intelligibility of hearing-impaired persons, or just on the question of hearing comfort. Concerning these subjects, different algorithms intending to improve the hearing ability are presented in this paper. These are automatic gain controls, directional microphones, and noise reduction algorithms. Besides the audiological point of view, there are several purely technical problems which have to be solved. An important one is the acoustic feedback. Another instance is the proper automatic control of all hearing aid components by means of a classification unit. In addition to an overview of state-of-the-art algorithms, this paper focuses on future trends.

  14. Introduction: The Case for Diversity in Research on Mental Health and HIV/AIDS

    PubMed Central

    Forsyth, Andrew; Marquez, Ernest D.; McClure, Shelia

    2009-01-01

    This introductory article provides background and sets the stage for the mentoring programs described in this special supplement. The goal of these programs is to develop scientists from racial/ethnic groups underrepresented in the area of HIV/AIDS research on issues related to mental health. We describe recent epidemiological trends associated with HIV infection in diverse populations, the need for mentoring programs to study disparities, and the ongoing mentoring programs supported by the National Institutes of Health targeting investigators underrepresented in the workforce. We also provide a summary of the content of the articles to follow. We conclude with a comment on future needs and actions. PMID:19246664

  15. Rethinking the conceptual terrain of AIDS scholarship: lessons from comparing 27 years of AIDS and climate change research

    PubMed Central

    2009-01-01

    Background While there has recently been significant medical advance in understanding and treating HIV, limitations in understanding the complex social dimensions of HIV/AIDS epidemics continue to restrict a host of prevention and development efforts from community through to international levels. These gaps are rooted as much in limited conceptual development as they are in a lack of empirical research. Methods In this conceptual article, the authors compare and contrast the evolution of climate change and AIDS research. They demonstrate how scholarship and response in these two seemingly disparate areas share certain important similarities, such as the "globalization" of discourses and associated masking of uneven vulnerabilities, the tendency toward techno-fixes, and the polarization of debates within these fields. They also examine key divergences, noting in particular that climate change research has tended to be more forward-looking and longer-term in focus than AIDS scholarship. Conclusion Suggesting that AIDS scholars can learn from these key parallels and divergences, the paper offers four directions for advancing AIDS research: (1) focusing more on the differentiation of risk and responsibility within and among AIDS epidemics; (2) taking (back) on board social justice approaches; (3) moving beyond polarized debates; and (4) shifting focus from reactive to forward-looking and proactive approaches. PMID:19807923

  16. What is the future of biomedical research?

    PubMed

    Tebala, Giovanni Domenico

    2015-10-01

    Randomized controlled trials require hard work and financial commitment, whereas meta-analyses and systematic reviews can be relatively easy to perform and often get published in high impact journals. Many researchers might decide to devote themselves to the latter approach, resulting in a negative impact on clinical research. We have reviewed the number of indexed meta-analyses and systematic reviews on PubMed and compared it with the number of randomized controlled trials over the same period. Statistical analysis showed an exponential increase of synthetic studies with respect to randomized trials. The ratio between RCTs and synthetic studies is quickly decreasing. These results suggest that a growing number of researchers might prefer to commit themselves to synthetic studies more than be involved in more time consuming and funds demanding observational trials. If we are unable to invert this trend, in the future we will have a growing number of synthetic studies utilizing someone else's original data and fewer raw data to base our knowledge upon. PMID:26194725

  17. Leadership: current theories, research, and future directions.

    PubMed

    Avolio, Bruce J; Walumbwa, Fred O; Weber, Todd J

    2009-01-01

    This review examines recent theoretical and empirical developments in the leadership literature, beginning with topics that are currently receiving attention in terms of research, theory, and practice. We begin by examining authentic leadership and its development, followed by work that takes a cognitive science approach. We then examine new-genre leadership theories, complexity leadership, and leadership that is shared, collective, or distributed. We examine the role of relationships through our review of leader member exchange and the emerging work on followership. Finally, we examine work that has been done on substitutes for leadership, servant leadership, spirituality and leadership, cross-cultural leadership, and e-leadership. This structure has the benefit of creating a future focus as well as providing an interesting way to examine the development of the field. Each section ends with an identification of issues to be addressed in the future, in addition to the overall integration of the literature we provide at the end of the article. PMID:18651820

  18. Future Directions of Delirium Research and Management

    PubMed Central

    Hughes, Christopher G.; Brummel, Nathan E.; Vasilevskis, Eduard E.; Girard, Timothy D.; Pandharipande, Pratik P.

    2013-01-01

    Delirium is a prevalent organ dysfunction in critically ill patients associated with significant morbidity and mortality, requiring advancements in the clinical and research realms to improve patient outcomes. Increased clinical recognition and utilization of delirium assessment tools, along with clarification of specific risk factors and presentations in varying patient populations, will be necessary in the future. To improve predictive models for outcomes, the continued development and implementation of delirium assessment tools and severity scoring systems will be required. The interplay between the pathophysiological pathways implicated in delirium and resulting clinical presentations and outcomes will need to guide the development of appropriate prevention and treatment protocols. Multicenter randomized controlled trials of interventional therapies will then need to be performed to test their ability to improve clinical outcomes. Physical and cognitive rehabilitation measures need to be further examined as additional means of improving outcomes from delirium in the hospital setting. PMID:23040289

  19. Nanofluid technology : current status and future research.

    SciTech Connect

    Choi, S. U.-S.

    1998-10-20

    Downscaling or miniaturization has been a recent major trend in modern science and technology. Engineers now fabricate microscale devices such as microchannel heat exchangers, and micropumps that are the size of dust specks. Further major advances would be obtained if the coolant flowing in the microchannels were to contain nanoscale particles to enhance heat transfer. Nanofluid technology will thus be an emerging and exciting technology of the 21st century. This paper gives a brief history of the Advanced Fluids Program at Argonne National Laboratory (ANL), discusses the concept of nanofluids, and provides an overview of the R and D program at ANL on the production, property characterization, and performance of nanofluids. It also describes examples of potential applications and benefits of nanofluids. Finally, future research on the fundamentals and applications of nanofluids is addressed.

  20. AIDS and food production in East and Central Africa: a research outline.

    PubMed

    Barnett, T; Blaikie, P

    1989-02-01

    AIDS has penetrated at least 42 countries in Africa. Death of Africans usually occurs within 3 years of diagnosis. Not much is currently known about the demographics of the disease or about its impact on economic and social behavior, farming, and food production. There is currently a food crisis in Africa, so it is appropriate to study how much of an impact this disease has on future food production. In order to study the problem, one must predict the spread of AIDS. 2nd, one must infer how labor loss effects current rural production. Labor loss will cause changes in organization of production, technology, and types of crops grown. As a crisis increases, certain groups will be cut out of the food distribution. Characterizations such as these allow the mapping of areas vulnerable to labor loss. Field analysis and modeling must substantiate the theories and predictions. This paper describes the research design which will be used by 2 researchers from the Overseas Development Group of the University of East Anglia to measure the impact of AIDS on food production, working initially in a high HIV - prevalent area in Uganda. PMID:12281937

  1. The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints.

    PubMed

    Shiboski, C H; Patton, L L; Webster-Cyriaque, J Y; Greenspan, D; Traboulsi, R S; Ghannoum, M; Jurevic, R; Phelan, J A; Reznik, D; Greenspan, J S

    2009-07-01

    The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), the largest HIV clinical trials organization in the world. Its main objective is to investigate oral complications associated with HIV/AIDS as the epidemic is evolving, in particular, the effects of antiretrovirals on oral mucosal lesion development and associated fungal and viral pathogens. The OHARA infrastructure comprises: the Epidemiologic Research Unit (at the University of California San Francisco), the Medical Mycology Unit (at Case Western Reserve University) and the Virology/Specimen Banking Unit (at the University of North Carolina). The team includes dentists, physicians, virologists, mycologists, immunologists, epidemiologists and statisticians. Observational studies and clinical trials are being implemented at ACTG-affiliated sites in the US and resource-poor countries. Many studies have shared end-points, which include oral diseases known to be associated with HIV/AIDS measured by trained and calibrated ACTG study nurses. In preparation for future protocols, we have updated existing diagnostic criteria of the oral manifestations of HIV published in 1992 and 1993. The proposed case definitions are designed to be used in large-scale epidemiologic studies and clinical trials, in both US and resource-poor settings, where diagnoses may be made by non-dental healthcare providers. The objective of this article is to present updated case definitions for HIV-related oral diseases that will be used to measure standardized clinical end-points in OHARA studies, and that can be used by any investigator outside of OHARA/ACTG conducting clinical research that pertains to these end-points. PMID:19594839

  2. Photometric support for future astonomical research

    NASA Technical Reports Server (NTRS)

    Hall, D. S.; Genet, R. M.

    1985-01-01

    The I.A.P.P.P. is described and how that organization can provide photometric support for future astronomical research projects such as the 1982-1984 eclipse of epsilon Aurigae discussed at this workshop. I.A.P.P.P., International Amateur-Professional Photoelectric Photometry, is an organization founded in Fairborn, Ohio by the authors in 1980. Its purpose is to encourage contact between amateur and professional astronomers interested in photoelectric photometry, for their mutual benefit and for the benefit of astronomical research. Aspects dealt with include instrumentation, electronics, computer hardware and software, observing techniques, data reduction, and observing programs. Starting with the June 1980 issue, I.A.P.P.P. has published the quarterly I.A.P.P.P. Communications. The Communications contain articles dealing with all the above aspects of photoelectric photometry, although it does not publish observational results as such. Photoelectric photometry obtained by amateurs is published in the same journals which publish photometry obtained by professionals.

  3. Cultural psychiatry: research strategies and future directions.

    PubMed

    Kirmayer, Laurence J; Ban, Lauren

    2013-01-01

    This chapter reviews some key aspects of current research in cultural psychiatry and explores future prospects. The first section discusses the multiple meanings of culture in the contemporary world and their relevance for understanding mental health and illness. The next section considers methodological strategies for unpacking the concept of culture and studying the impact of cultural variables, processes and contexts. Multiple methods are needed to address the many different components or dimensions of cultural identity and experience that constitute local worlds, ways of life or systems of knowledge. Quantitative and observational methods of clinical epidemiology and experimental science as well as qualitative ethnographic methods are needed to capture crucial aspects of culture as systems of meaning and practice. Emerging issues in cultural psychiatric research include: cultural variations in illness experience and expression; the situated nature of cognition and emotion; cultural configurations of self and personhood; concepts of mental disorder and mental health literacy; and the prospect of ecosocial models of health and culturally based interventions. The conclusion considers the implications of the emerging perspectives from cultural neuroscience for psychiatric theory and practice. PMID:23816867

  4. Sepsis: a roadmap for future research.

    PubMed

    Cohen, Jonathan; Vincent, Jean-Louis; Adhikari, Neill K J; Machado, Flavia R; Angus, Derek C; Calandra, Thierry; Jaton, Katia; Giulieri, Stefano; Delaloye, Julie; Opal, Steven; Tracey, Kevin; van der Poll, Tom; Pelfrene, Eric

    2015-05-01

    Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research. PMID:25932591

  5. Addressing Future Epidemics: Historical Human Rights Lessons from the AIDS Pandemic

    PubMed Central

    Mehta, Ambar; Quinn, Thomas C.

    2016-01-01

    Introduction The Ebola epidemic in West Africa sparked many ethical and polarizing public health questions on how to adequately control transmission of the virus. These deliberations had and will continue to influence patients, healthcare workers, public perceptions of disease, and governmental responses. Such extensive and potential ramifications warranted an analysis of prior epidemics to sufficiently inform policy makers and prepare them and other authorities for future epidemics. We analyzed how the general public, medical institutions, federal government, and patients themselves responded during the early stages of the AIDS pandemic in two different countries and cultures, the United States and India. Discussion Our analysis identified four key findings pertaining to the human rights of patients and healthcare workers and to the crucial roles of the government and medical community. The first demands that authoritative officials acknowledge the presence of high-risk behaviors and properly educate the public without stigmatizing groups of individuals. For this task, the medical community and federal government must form and display to the public a respectful and collaborative partnership towards battling the epidemic. These two synergistic endeavors will then allow appropriate officials to implement effective, yet civil, interventions for limiting transmission. Finally, the same officials must ensure that their interventions maintain the human rights of high-risk populations and of healthcare workers. Conclusions Applying these findings to future epidemics of infectious diseases can aid policy makers in navigating complicated ethical and public health questions, and help prevent them from repeating past mistakes in handling epidemics. PMID:27284578

  6. Research is the Future, the Future is…….

    PubMed

    Gilchrist, Francis J

    2016-01-01

    Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is in progress. Four research areas are discussed that are likely to contribute to the continued academic output from the unit. These are the use of selected ion flow tube mass spectrometry for the detection of biomarkers associated with pulmonary pathogens, the measurement of lung clearance index in preschool children, structured light plethysmography in children and the use of oral prednisolone for asthma exacerbations in children. PMID:26527356

  7. Computer-Aided Nodule Assessment and Risk Yield Risk Management of Adenocarcinoma: The Future of Imaging?

    PubMed

    Foley, Finbar; Rajagopalan, Srinivasan; Raghunath, Sushravya M; Boland, Jennifer M; Karwoski, Ronald A; Maldonado, Fabien; Bartholmai, Brian J; Peikert, Tobias

    2016-01-01

    Increased clinical use of chest high-resolution computed tomography results in increased identification of lung adenocarcinomas and persistent subsolid opacities. However, these lesions range from very indolent to extremely aggressive tumors. Clinically relevant diagnostic tools to noninvasively risk stratify and guide individualized management of these lesions are lacking. Research efforts investigating semiquantitative measures to decrease interrater and intrarater variability are emerging, and in some cases steps have been taken to automate this process. However, many such methods currently are still suboptimal, require validation and are not yet clinically applicable. The computer-aided nodule assessment and risk yield software application represents a validated tool for the automated, quantitative, and noninvasive tool for risk stratification of adenocarcinoma lung nodules. Computer-aided nodule assessment and risk yield correlates well with consensus histology and postsurgical patient outcomes, and therefore may help to guide individualized patient management, for example, in identification of nodules amenable to radiological surveillance, or in need of adjunctive therapy. PMID:27568149

  8. Neurosciences research in space Future directions

    NASA Astrophysics Data System (ADS)

    Sulzman, Frank M.; Wolfe, James W.

    Future research in the neurosciences can best be understood in the context of NASA's life sciences goals in the near term (1990-1995), mid term (1995-2000), and long term (2000 and beyond). Since NASA is planning short-duration Spacelab and International Microgravity Laboratory (IML) flights for many years to come, the acute effects of exposure to microgravity will continue to be of experimental and operational interest in the near term. To this end, major new areas of research will be devoted to ground-based studies of preflight adaptation trainers and their efficacy in preventing or reducing the incidence of space motion sickness. In addition, an extensive series of studies of the vestibular system will be conducted inflight on the IML-1 mission The IML-2 mission will emphasize behavior and performance, biological rhythms, and further vestibular studies. In the mid-term period, Spacelab missions will employ new technology such as magnetic recording techniques in order to evaluate changes in the processing of sensory and motor inputs at the brainstem and cortical level during exposure to microgravity. Two Space Life Sciences (SLS) missions planned for the mid to late 1990's, SLS-4 and SLS-5, will utilize an onboard centrifuge facility that will enable investigators to study the effects of partial gravity on sensory and motor function. In the long term (2000 and beyond), Space Station Freedom and long-duration missions will provide opportunities to explore new options in the neurosciences, such as sensory substitution and augmentation, through the use of physical sensors to provide three-dimensional tactile-visual, tactile-auditory and tactile-somatosensory inputs. The use of this technology will be extremely important in the area of robotic telepresence. Finally, Space Station Freedom and proposed LifeSat missions will provide neuroscientists the opportunity to study the effects of partial gravity and microgravity on neuronal plasticity.

  9. Current and Future Research at DANCE

    NASA Astrophysics Data System (ADS)

    Jandel, M.; Baramsai, B.; Bredeweg, T. A.; Couture, A.; Hayes, A.; Kawano, T.; Mosby, S.; Rusev, G.; Stetcu, I.; Taddeucci, T. N.; Talou, P.; Ullmann, J. L.; Walker, C. L.; Wilhelmy, J. B.

    2015-05-01

    An overview of the current experimental program on measurements of neutron capture and neutron induced fission at the Detector for Advanced Neutron Capture Experiments (DANCE) is presented. Three major projects are currently under way: 1) high precision measurements of neutron capture cross sections on Uranium isotopes, 2) research aimed at studies of the short-lived actinide isomer production in neutron capture on 235U and 3) measurements of correlated data of fission observables. New projects include developments of auxiliary detectors to improve the capability of DANCE. We are building a compact, segmented NEUtron detector Array at DANCE (NEUANCE), which will be installed in the central cavity of the DANCE array. It will provide experimental information on prompt fission neutrons in coincidence with the prompt fission gamma-rays measured by 160 BaF2 crystals of DANCE. Unique correlated data will be obtained for neutron capture and neutron-induced fission using the DANCE-NEUANCE experimental set up in the future.

  10. Current and Future Research at DANCE

    SciTech Connect

    Jandel, M.; Baramsai, B.; Bredeweg, T. A.; Couture, A.; Hayes, A.; Kawano, T.; Mosby, S.; Rusev, G.; Stetcu, I.; Taddeucci, T. N.; Talou, P.; Ullmann, J. L.; Walker, C. L.; Wilhelmy, J. B.

    2015-05-28

    An overview of the current experimental program on measurements of neutron capture and neutron induced fission at the Detector for Advanced Neutron Capture Experiments (DANCE) is presented. Three major projects are currently under way: 1) high precision measurements of neutron capture cross sections on Uranium isotopes, 2) research aimed at studies of the short-lived actinide isomer production in neutron capture on 235U and 3) measurements of correlated data of fission observables. New projects include developments of auxiliary detectors to improve the capability of DANCE. We are building a compact, segmented NEUtron detector Array at DANCE (NEUANCE), which will be installed in the central cavity of the DANCE array. It will thus provide experimental information on prompt fission neutrons in coincidence with the prompt fission gamma-rays measured by 160 BaF2 crystals of DANCE. Additionally, unique correlated data will be obtained for neutron capture and neutron-induced fission using the DANCE-NEUANCE experimental set up in the future.

  11. Current and Future Research at DANCE

    DOE PAGESBeta

    Jandel, M.; Baramsai, B.; Bredeweg, T. A.; Couture, A.; Hayes, A.; Kawano, T.; Mosby, S.; Rusev, G.; Stetcu, I.; Taddeucci, T. N.; et al

    2015-05-28

    An overview of the current experimental program on measurements of neutron capture and neutron induced fission at the Detector for Advanced Neutron Capture Experiments (DANCE) is presented. Three major projects are currently under way: 1) high precision measurements of neutron capture cross sections on Uranium isotopes, 2) research aimed at studies of the short-lived actinide isomer production in neutron capture on 235U and 3) measurements of correlated data of fission observables. New projects include developments of auxiliary detectors to improve the capability of DANCE. We are building a compact, segmented NEUtron detector Array at DANCE (NEUANCE), which will be installedmore » in the central cavity of the DANCE array. It will thus provide experimental information on prompt fission neutrons in coincidence with the prompt fission gamma-rays measured by 160 BaF2 crystals of DANCE. Additionally, unique correlated data will be obtained for neutron capture and neutron-induced fission using the DANCE-NEUANCE experimental set up in the future.« less

  12. How Does Institutional Grant Aid Impact College Choice? Research Brief

    ERIC Educational Resources Information Center

    Hurwitz, Michael

    2012-01-01

    New evidence on how students' choice of postsecondary institution is sensitive to grant aid offers from the colleges and universities. Institutional aid sensitivity is largest for students from the least wealthy families but does not vary by race/ethnicity or measured academic ability. A technical appendix is included.

  13. The Forum on AIDS: An Exercise in Research and Statesmanship

    ERIC Educational Resources Information Center

    Goldfinch, Ellen

    2007-01-01

    The AIDS pandemic has become an important force that is shaping the world and will certainly have an enormous impact on the lives of young people today. Forty million people around the world are suffering from HIV/AIDS and, every year, eight million people die of this disease. As both school librarian and teacher of the Challenge and Change course…

  14. Research in a Scenario of Change: Why Research Institutions Should Begin To Plan for the Future.

    ERIC Educational Resources Information Center

    Krebs, Martha A.

    1997-01-01

    Discusses emerging ideas about the future of federal research and development activities as they relate to the future of industry and especially to institutions of higher learning. Discusses energy research today, a future perspective, the future of the research community, and challenges. Highlights the future orientation of the Office of Energy…

  15. HIV prevention research: accomplishments and challenges for the third decade of AIDS.

    PubMed Central

    Auerbach, J D; Coates, T J

    2000-01-01

    The past 2 decades have taught us that HIV prevention can work. We now have evidence from places as diverse as Senegal, Thailand, Uganda, and Australia that concerted HIV prevention efforts at the national level have resulted in the maintenance of low seroprevalence rates where they otherwise would have been expected to rise. We are beginning to observe declining rates of HIV prevalence and incidence in places and populations with historically high rates--for example, injection drug users in New York City. This trend points to the long-term impact of prevention efforts in those communities. The best of these efforts have been based on sound scientific research. As we move into the third decade of the AIDS epidemic, it is important to restate principles, acknowledge advances, and identify challenges and future directions in HIV prevention research. PMID:10897177

  16. Prevention of AIDS and HIV infection: needs and priorities for epidemiologic research.

    PubMed Central

    Allen, J R; Curran, J W

    1988-01-01

    By the end of 1987, almost 50,000 cases of acquired immunodeficiency syndrome (AIDS) will have been reported in the United States. Although the primary epidemiology of the disease has been described, much work remains to be done to complete our understanding of the dynamics of transmission and infection with the causative virus, human immunodeficiency virus (HIV). At the state and local level, the highest priorities for epidemiologic research are to understand better the precise populations at risk of prevalent and incident HIV infection, and to use this information to direct and monitor specific prevention programs that are likely to be effective for the populations at risk. These parallel efforts-sophisticated investigative epidemiologic research and applied epidemiologic and serosurveillance studies-must be expanded rapidly and continued for the forseeable future if we are to accomplish the goal of preventing further spread of HIV. PMID:3279836

  17. An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio.

    PubMed

    Gayer, Christopher C; Crowley, Matthew J; Lawrence, William F; Gierisch, Jennifer M; Gaglio, Bridget; Williams, John W; Myers, Evan R; Kendrick, Amy; Slutsky, Jean; Sanders, Gillian D

    2016-07-01

    Decision aids (DAs) help patients make informed healthcare decisions in a manner consistent with their values and preferences. Despite their promise, DAs developed with public research dollars are not being implemented and adopted in real-world patient care settings at a rate consistent with which they are being developed. To appraise the sum of the parts of the portfolio and create a strategic imperative surrounding future funding, the Patient-Centered Outcomes Research Institute (PCORI) tasked the Duke Evidence Synthesis Group with evaluating its DA portfolio. This paper describes PCORI's portfolio of DAs according to the Duke Evidence Synthesis Group's analysis in the context of PCORI's mission and the field of decision science. The results revealed a diversity within PCORI's portfolio of funded DA projects. Findings support the movement toward more rigorous DA development, assessment and maintenance. PCORI's funding priorities related to DAs are clarified and comparative questions of interest are posed. PMID:27298206

  18. Breaking the Culture of Silence in Checkmating HIV/AIDS as a Teacher-Researcher

    ERIC Educational Resources Information Center

    Esau, O.

    2010-01-01

    In my investigation I set out to break the HIV/AIDS culture of silence and emphasize the role of the teacher as a researcher and critical change agent in an HIV/AIDS challenged society. My work demonstrates how teachers could play such a role by encouraging learners' participation in sport. The sport, I focussed on in my action research project…

  19. Participating in Alzheimer's Research: For Yourself and Future Generations

    MedlinePlus

    ... ADEAR Participating in Alzheimer's Research: For Yourself and Future Generations Introduction Participating in a clinical trial or ... prevent Alzheimer's and other diseases, and could help future generations lead healthier lives. "When I was diagnosed ...

  20. AIDS: A National Dilemma.

    ERIC Educational Resources Information Center

    Issues in Science and Technology, 1987

    1987-01-01

    Contains excerpts from a special study on the AIDS epidemic by the Institute of Medicine and National Academy of Sciences. Presents an overview of the problem, outlines educational needs and public health measures, and identifies future research needs. (ML)

  1. Training Needs of Nurses in Public Hospitals in Australia: Review of Current Practices and Future Research Agenda

    ERIC Educational Resources Information Center

    Carlisle, Joanna; Bhanugopan, Ramudu; Fish, Alan

    2011-01-01

    Purpose: This paper seeks to provide an overview of the concept of training needs analysis (TNA), current practice, models and the impact that training needs analysis currently has on nurses in public hospitals in Australia. Thus, the paper should aid future research in the area of TNA of nurses through helping researchers to clarify the…

  2. US computer research networks: Current and future

    NASA Technical Reports Server (NTRS)

    Kratochvil, D.; Sood, D.; Verostko, A.

    1989-01-01

    During the last decade, NASA LeRC's Communication Program has conducted a series of telecommunications forecasting studies to project trends and requirements and to identify critical telecommunications technologies that must be developed to meet future requirements. The Government Networks Division of Contel Federal Systems has assisted NASA in these studies, and the current study builds upon these earlier efforts. The current major thrust of the NASA Communications Program is aimed at developing the high risk, advanced, communications satellite and terminal technologies required to significantly increase the capacity of future communications systems. Also, major new technological, economic, and social-political events and trends are now shaping the communications industry of the future. Therefore, a re-examination of future telecommunications needs and requirements is necessary to enable NASA to make management decisions in its Communications Program and to ensure the proper technologies and systems are addressed. This study, through a series of Task Orders, is helping NASA define the likely communication service needs and requirements of the future and thereby ensuring that the most appropriate technology developments are pursued.

  3. The Future of Educational Research in the Professions.

    ERIC Educational Resources Information Center

    Bland, Carole J.; And Others

    1986-01-01

    This issue of the "Professions Education Research Notes" is devoted to the theme of "The Future of Educational Research in the Professions." Four articles have been extracted from the issue to form this document: "The Future of Educational Research in the Professions," by Carole J. Bland, introduces the other articles and describes, as context for…

  4. Does Arts-Based Research Have a Future?

    ERIC Educational Resources Information Center

    Eisner, Elliot

    2006-01-01

    This article focuses on the future of arts-based research in education. The author contends that there are several features that need to be taken into account if arts-based educational research is to have a future. First, arts-based educational research needs to have a cadre of scholars committed to its exploration--individuals who regard…

  5. Component research for future propulsion systems

    NASA Technical Reports Server (NTRS)

    Walker, C. L.; Weden, G. J.; Zuk, J.

    1981-01-01

    The factors affecting the helicopter market for the past, present, and future are reviewed. Acquisition cost, mission reliability, life cycle cost and civil and military aspects are reviewed. The potential for advanced vehicle configurations with substantial improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Advanced propulsion systems required to support these vehicle configurations and the component technology for the engine systems are discussed. The selection of components in areas of economics and efficiency is considered.

  6. How funding structures for HIV/AIDS research shape outputs and utilization: a Swiss case study

    PubMed Central

    2011-01-01

    Background Research policy in the field of HIV has changed substantially in recent decades in Switzerland. Until 2004, social science research on HIV/AIDS was funded by specialized funding agencies. After 2004, funding of such research was “normalized” and integrated into the Swiss National Science Foundation as the main funding agency for scientific research in Switzerland. This paper offers a longitudinal analysis of the relationship between the changing nature of funding structures on the one hand and the production and communication of policy-relevant scientific knowledge in the field of HIV on the other hand. Methods The analysis relies on an inventory of all social sciences research projects on HIV in Switzerland that were funded between 1987 and 2010, including topics covered and disciplines involved, as well as financial data. In addition, in-depth interviews were conducted with 18 stakeholders. Results The analysis highlights that the pre-2004 funding policy ensured good coverage of important social science research themes. Specific incentives and explicit promotion of social science research related to HIV gave rise to a multidisciplinary, integrative and health-oriented approach. The abolition of a specific funding policy in 2004 was paralleled by a drastic reduction in the number of social science research projects submitted for funding, and a decline of public money dedicated to such research. Although the public administration in charge of HIV policy still acknowledges the relevance of findings from social sciences for the development of prevention, treatment and care, HIV-related social science research does not flourish under current funding conditions. Conclusions The Swiss experience sheds light on the difficulties of sustaining social science research and multidisciplinary approaches related to HIV without specialized funding agencies. Future funding policy might not necessarily require specialized agencies, but should better take into

  7. Research Challenges in Future Health Care Systems

    NASA Astrophysics Data System (ADS)

    Kulatunga, Harini

    Future health care systems will involve a network of heterogeneous resources providing different levels of service and will comprise of a physical and a virtual decision and control layer. The initial results presented here will lead to health care delivery with on-line decision making in order to meet QoS requirements and management targets.

  8. Artificial Intelligence Research Branch future plans

    NASA Technical Reports Server (NTRS)

    Stewart, Helen (Editor)

    1992-01-01

    This report contains information on the activities of the Artificial Intelligence Research Branch (FIA) at NASA Ames Research Center (ARC) in 1992, as well as planned work in 1993. These activities span a range from basic scientific research through engineering development to fielded NASA applications, particularly those applications that are enabled by basic research carried out in FIA. Work is conducted in-house and through collaborative partners in academia and industry. All of our work has research themes with a dual commitment to technical excellence and applicability to NASA short, medium, and long-term problems. FIA acts as the Agency's lead organization for research aspects of artificial intelligence, working closely with a second research laboratory at the Jet Propulsion Laboratory (JPL) and AI applications groups throughout all NASA centers. This report is organized along three major research themes: (1) Planning and Scheduling: deciding on a sequence of actions to achieve a set of complex goals and determining when to execute those actions and how to allocate resources to carry them out; (2) Machine Learning: techniques for forming theories about natural and man-made phenomena; and for improving the problem-solving performance of computational systems over time; and (3) Research on the acquisition, representation, and utilization of knowledge in support of diagnosis design of engineered systems and analysis of actual systems.

  9. Research on Frequency Transposition for Hearing Aids. Interim Report.

    ERIC Educational Resources Information Center

    Pickett, James M.

    To investigate impaired residual disciminiation for low-frequency formants and its influence on electronic compensation effectiveness, evaluations were made on impaired discrimination for speech formants, synthetic enhancement of consonants, wearable transposer aids, and a speech perception survey. Results showed that certain persons with severe…

  10. Aircraft Research and Technology for Future Fuels

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The potential characteristics of future aviation turbine fuels and the property effects of these fuels on propulsion system components are examined. The topics that are discussed include jet fuel supply and demand trends, the effects of refining variables on fuel properties, shekle oil processing, the characteristics of broadened property fuels, the effects of fuel property variations on combustor and fuel system performance, and combuster and fuel system technology for broadened property fuels.

  11. Component research for future propulsion systems

    NASA Technical Reports Server (NTRS)

    Walker, C. L.; Weden, G. J.; Zuk, J.

    1981-01-01

    A review of factors related to the acquisition and life-cycle cost, and mission reliability of helicopters is given. The potential for advanced vehicle configurations with improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Special attention is given to advanced propulsion systems and related component technologies, and system requirements, powerplants and component thrusts, compressor designs, combustion systems, turbine efficiency, blade tip treatment concepts and shaft dynamics are discussed in detail.

  12. Assessment of speech perception in children with cochlear implants and tactile aids: what should the future hold?

    PubMed

    Carney, A E

    1991-01-01

    The purpose of this paper is to propose a rationale for the future development of speech perception evaluation materials for children using either cochlear implants or vibrotactile aids as sensory prosthetic devices. It is suggested that future evaluation tools extend beyond the assessment of device efficacy. In particular, they should address issues of normal perceptual development in children, as well as the results of intervention with children using these sensory prosthetic devices. PMID:2069182

  13. Call for a Computer-Aided Cancer Detection and Classification Research Initiative in Oman.

    PubMed

    Mirzal, Andri; Chaudhry, Shafique Ahmad

    2016-01-01

    Cancer is a major health problem in Oman. It is reported that cancer incidence in Oman is the second highest after Saudi Arabia among Gulf Cooperation Council countries. Based on GLOBOCAN estimates, Oman is predicted to face an almost two-fold increase in cancer incidence in the period 2008-2020. However, cancer research in Oman is still in its infancy. This is due to the fact that medical institutions and infrastructure that play central roles in data collection and analysis are relatively new developments in Oman. We believe the country requires an organized plan and efforts to promote local cancer research. In this paper, we discuss current research progress in cancer diagnosis using machine learning techniques to optimize computer aided cancer detection and classification (CAD). We specifically discuss CAD using two major medical data, i.e., medical imaging and microarray gene expression profiling, because medical imaging like mammography, MRI, and PET have been widely used in Oman for assisting radiologists in early cancer diagnosis and microarray data have been proven to be a reliable source for differential diagnosis. We also discuss future cancer research directions and benefits to Oman economy for entering the cancer research and treatment business as it is a multi-billion dollar industry worldwide. PMID:27268600

  14. Research Universities and the Future of America

    ERIC Educational Resources Information Center

    Duderstadt, James J.

    2012-01-01

    The crucial importance of the research university as a key asset in achieving economic prosperity and security is widely understood, as evidenced by the efforts that nations around the globe are making to create and sustain institutions of world-class quality. Yet, while America's research universities remain the strongest in the world, they are…

  15. A Bright Future for Interdisciplinary Multilingualism Research

    ERIC Educational Resources Information Center

    Comanaru, Ruxandra-S.; Dewaele, Jean-Marc

    2015-01-01

    Multilingualism is a prevalent reality in today's world. From an individual level to a societal one, multilingualism incorporates many aspects that have been studied extensively by diverse social research disciplines. The present article will explore the potential directions which multilingualism research can take, concentrating mainly on the…

  16. The Learning of Biology: A Structural Basis for Future Research

    ERIC Educational Resources Information Center

    Murray, Darrel L.

    1977-01-01

    This article reviews recent research studies and experiences relating the learning theories of Ausubel to biology instruction. Also some suggestions are made for future research on the learning of biology. (MR)

  17. Research on Hearing and Balance--Current and Future Developments.

    ERIC Educational Resources Information Center

    Snow, James B., Jr.

    1997-01-01

    This article reviews current research that has located disease genes causing hearing impairments, discovered the ability of sensory cells of the inner ear to regenerate, developed vaccines to prevent otitis media, developed programmable hearing aids, improved cochlear implants, and demonstrated the positive effects of physical therapy with balance…

  18. Future of Venus Research and Exploration

    NASA Astrophysics Data System (ADS)

    Glaze, L.; Limaye, S.; Nakamura, M.; Wilson, C.; Zasova, L.

    2014-04-01

    A great deal is known about Venus from the Venera, Pioneer-Venus, Magellan, and Venus Express missions. However, many significant questions remain regarding the origin, evolution and current geologic and atmospheric processes. Much can be learned from theoretical modeling of the planetary interior and atmospheric circulation, as well as from laboratory spectroscopic studies. However, to answer many of the outstanding questions, new space flight missions are needed. Multiple international space agencies are considering Venus as a possible destination for future exploration. Collaborative international participation provides a viable path to further understanding of Earth's sister planet and her role in the formation of our solar system.

  19. Component research for future propulsion systems

    NASA Technical Reports Server (NTRS)

    Walker, C. L.; Weden, G. J.; Zuk, J.

    1981-01-01

    Factors affecting the helicopter market are reviewed. The trade-offs involving acquisition cost, mission reliability, and life cycle cost are reviewed, including civil and military aspects. The potential for advanced vehicle configurations with substantial improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Advanced propulsion systems required to support these vehicle configurations are discussed, as well as the component technology for the engine systems. Considerations for selection of components in areas of economics and efficiency are presented.

  20. The Future of Higher Education and the Future of Higher Education Research

    ERIC Educational Resources Information Center

    Teichler, Ulrich

    2003-01-01

    Higher education research is closely linked to the debates on higher education policy and practice. It provides the information basis for decisions about the future of higher education. As the themes of the public debate on problems and reform needs in higher education change quickly, higher education research has to anticipate future problems and…

  1. Guiding future research on terrestrial ecosystem disturbance

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2013-04-01

    With North American ecosystems responsible for drawing hundreds of teragrams of carbon from the atmosphere each year, the tenuous balance of the terrestrial carbon budget can be upset for decades by disturbances such as fires, storms, disease outbreaks, insect infestations, and logging. Research cataloging the effects of such disturbances on regional carbon cycling tends to be sporadic or of limited scope. Most research has focused on forests but is less extensive for other important ecosystems such as grasslands or permafrost peatlands.

  2. Applying futures' research to nutrition education.

    PubMed

    Gayle, M E

    1987-09-01

    You, as individuals and as professionals, cannot be expected to solve all the problems of this decade and those projected for the future that I have discussed with you today, but you must accept the challenge to help bring individuals and society to a more holistic approach to a quality of life for all its members. The messages have gone out to children, youth, and adults that a young, thin, and beautiful image is all that is appropriate. Within the context of these messages individuals are confused and overwhelmed by their own inabilities to "be all that they can be." There are mixed messages in the media concerning drugs that are bad and drugs that are good, food that is bad and food that is good, and the connections to the environment. Your role and mine in this future will be to enter into partnerships with all policy-making and administrative agencies and with private sector groups, to work together and to share our many resources, experiences, and creative minds in moving healthy minds and bodies into the 21st century. Choices, Challenges, and Change--a time for new heroes. Who is yours? Mine is Pogo, who said, "I am faced with insurmountable opportunities." PMID:3624729

  3. Future human bone research in space

    NASA Technical Reports Server (NTRS)

    LeBlanc, A.; Shackelford, L.; Schneider, V.

    1998-01-01

    Skylab crewmembers demonstrated negative calcium (Ca) balance reaching about -300 mg/day by flight day 84. Limited bone density (BMD) measurements documented that bone was not lost equally from all parts of the skeleton. Subsequent BMD studies during long duration Russian flights documented the regional extent of bone loss. These studies demonstrated mean losses in the spine, femur neck, trochanter, and pelvis of about 1%-1.6% with large differences between individuals as well as between bone sites in a given individual. Limited available data indicate postflight bone recovery occurred in some individuals, but may require several years for complete restoration. Long duration bedrest studies showed a similar pattern of bone loss and calcium balance (-180 mg/day) as spaceflight. During long duration bedrest, resorption markers were elevated, formation markers were unchanged, 1,25 vitamin D (VitD) and calcium absorption were decreased, and serum ionized Ca was increased. Although this information is a good beginning, additional spaceflight research is needed to assess architectural and subregional bone changes, elucidate mechanisms, and develop efficient as well as effective countermeasures. Space research poses a number of unique problems not encountered in ground-based laboratory research. Therefore, researchers contemplating human spaceflight research need to consider a number of unique problems related to spaceflight in their experimental design.

  4. Roadmapping Future E-Government Research

    NASA Astrophysics Data System (ADS)

    Bicking, Melanie

    Global electronic markets, virtual organisations, virtual identities, virtual products and services, and Internet-related crime are growing in prominence and importance. In a world that is increasingly non-physical and borderless, what are government's roles, responsibilities and limitations? The Internet plays a central role within the transformation process from traditional governments towards modern and innovative government that the requirements of an Information Society. Based on the findings of the eGovRTD2020 project, that aims at identifying key research challenges and at implementing a model for a holistic government with horizon 2020, this paper explains the necessity to investigate and understand the Internet and in particular government's role and responsibilities in it. Furthermore, the paper provides a research roadmap that details how to address certain issue related research questions.

  5. Future directions in human-environment research.

    PubMed

    Moran, Emilio F; Lopez, Maria Claudia

    2016-01-01

    Human-environment research in the 21st century will need to change in major ways. It will need to integrate the natural and the social sciences; it will need to engage stakeholders and citizens in the design of research and in the delivery of science for the benefit of society; it will need to address ethical and democratic goals; and it will need to address a myriad of important theoretical and methodological challenges that continue to impede progress in the advance of sustainability science. PMID:26422805

  6. Research and Development of Future Muon Collider

    SciTech Connect

    Yonehara, K.; /Fermilab

    2012-05-01

    Muon collider is a considerable candidate of the next generation high-energy lepton collider machine. A novel accelerator technology must be developed to overcome several intrinsic issues of muon acceleration. Recent research and development of critical beam elements for a muon accelerator, especially muon beam phase space ionization cooling channel, are reviewed in this paper.

  7. The Future of Research in Industry

    NASA Astrophysics Data System (ADS)

    Duke, Charles

    2006-03-01

    Since 1990 the environment for and execution of industrial research has changed profoundly. See, e.g., R. Buderi, Engines of Tomorrow (Simon and Shuster, New York, 2000); H. W. Chesbrough, Open Innovation (Harvard Business School Press, Boston, 2003); C. B. Duke, Creating Economic Value from Research Knowledge (The Industrial Physicist, Aug-Sept. 2004, pp. 29-31). According to Thomas L. Friedman (``The World is Flat,'' Farrar, Straus and Giroux, New York, 2005) a new global communications-collaboration platform has ``flattened'' the world. National alarms have been raised about the US capability to compete in this changed environment. See, e.g., ``America's Tech Might Slipping?,'' Business Week, March 14, 2004; ``Globalization and Engineering,'' The Bridge, National Academy of Engineering, Fall 2005; ``Rising Above the Gathering Storm,'' National Academy of Sciences, 2005. In this presentation I indicate why firms perform research and how they generate economic value from it. Then I discuss the profound changes in the environment for these activities since 1990. This leads to a consideration of how firms are modifying their Research and Development activities to deal with this situation. I close by noting implications of these developments on the role of physics and the careers of physical scientists in the 21st century.

  8. Biology Education Research: Lessons and Future Directions

    ERIC Educational Resources Information Center

    Singer, Susan R.; Nielsen, Natalie R.; Schweingruber, Heidi A.

    2013-01-01

    Biologists have long been concerned about the quality of undergraduate biology education. Over time, however, biology faculty members have begun to study increasingly sophisticated questions about teaching and learning in the discipline. These scholars, often called biology education researchers, are part of a growing field of inquiry called…

  9. Future Directions in ADHD Etiology Research

    ERIC Educational Resources Information Center

    Nigg, Joel T.

    2012-01-01

    Reviews salient emerging themes in the scientific literature related to identifying etiology and pathophysiology of ADHD. While bypassing the need for new treatment research, the review highlights three themes. First, recognition of the epigenetic effects is expected to revitalize the search for and mapping of early environmental influences on the…

  10. Soy Saponins: Current Research and Future Goals

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Saponins are a biologically active class of triterpenoid phytochemicals found in soybeans at concentrations similar to those of the isoflavones, and the role they may play in nutrition and health is not well understood. Research the functionality of these compounds in animals and humans has been ha...

  11. Future Directions in ADHD Etiology Research

    PubMed Central

    Nigg, Joel T.

    2015-01-01

    Reviews salient emerging themes in the scientific literature related to identifying etiology and pathophysiology of ADHD. While bypassing the need for new treatment research, the review highlights three themes. First, recognition of the epigenetic effects is expected to revitalize the search for and mapping of early environmental influences on the development of ADHD. Second, neurobiological findings will have limited impact if not examined in the context of significant race and cultural variation in ADHD-related developmental processes, and in the context of rapidly changing social and technological contexts of children’s development worldwide. Third, further examination of the phenotype and characterization of its dimensional and categorical structure remains a major need. Overall, the coming decades of etiology research on ADHD will be expected to capitalize on new scientific tools. The hope in the field is that new insights into fundamental prevention can emerge. PMID:22642834

  12. Directory of socio-behavioural research on HIV infection and AIDS in Zimbabwe.

    PubMed

    Bijlmakers, L A

    1993-02-01

    In July-August 1992, a directory was made of research projects on socio-behavioural aspects of HIV infection and AIDS in Zimbabwe. A total of 92 research projects were identified, most of which were already completed. Whilst there was a wide variety of topics, populations and geographical areas covered, there was a strong bias towards AIDS awareness and knowledge, attitudes and practices (KAP) studies. Many of these were not linked with any specific AIDS prevention programme or with policy making. Suggestions are given to make better use of existing scientific information. A call is made upon researchers to conduct action-oriented studies and to consult HIV/AIDS programme implementers when specifying 'researchable' problems, so as to increase the likelihood that the study results will indeed have an impact on policy making and programme implementation. PMID:8261502

  13. Creating the Future: Research and Technology

    NASA Technical Reports Server (NTRS)

    1998-01-01

    With the many different technical talents, Marshall Space Flight Center (MSFC) continues to be an important force behind many scientific breakthroughs. The MSFC's annual report reviews the technology developments, research in space and microgravity sciences, studies in space system concepts, and technology transfer. The technology development programs include development in: (1) space propulsion and fluid management, (2) structures and dynamics, (3) materials and processes and (4) avionics and optics.

  14. Future directions in aeronautical research and technology

    NASA Technical Reports Server (NTRS)

    Bower, R. E.

    1978-01-01

    The aeronautical R & D effort in NASA is discussed with emphasis on those areas where major needs and opportunities exist. In aerodynamics, areas selected for discussion include computational aerodynamics, transonic test techniques, high Reynolds number research, skin friction drag reduction, and propulsive lift. In propulsion, consideration is given to the areas of fuel-efficient subsonic propulsion, variable-flow engines, hypersonic propulsion, alternate fuels, and aircraft noise reduction. Consideration is also given to the utilization of advanced composites and integrated avionic systems.

  15. Prediction of Research Self-Efficacy and Future Research Involvement.

    ERIC Educational Resources Information Center

    Bishop, Rosean M.; And Others

    Although graduate programs hope that their students will be committed to research in their careers, most students express ambivalence towards research. Identifying the variables that predict involvement in research thus seems crucial. In this study 136 doctoral students from a wide range of disciplines completed the Research Self-Efficacy Scale…

  16. Phototriggerable Liposomes: Current Research and Future Perspectives

    PubMed Central

    Puri, Anu

    2013-01-01

    The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and consideration towards technological developments have also been recognized. Development of viable methods for on-demand spatial and temporal release of entrapped drugs from the nanocarriers is an arena that is likely to enhance the clinical suitability of drug-loaded nanocarriers. One such approach, which utilizes light as the external stimulus to disrupt and/or destabilize drug-loaded nanoparticles, will be the discussion platform of this article. Although several phototriggerable nanocarriers are currently under development, I will limit this review to the phototriggerable liposomes that have demonstrated promise in the cell culture systems at least (but not the last). The topics covered in this review include (i) a brief summary of various phototriggerable nanocarriers; (ii) an overview of the application of liposomes to deliver payload of photosensitizers and associated technologies; (iii) the design considerations of photoactivable lipid molecules and the chemical considerations and mechanisms of phototriggering of liposomal lipids; (iv) limitations and future directions for in vivo, clinically viable triggered drug delivery approaches and potential novel photoactivation strategies will be discussed. PMID:24662363

  17. Federal policy: Ryan White, OAR, testing newborns. Office of AIDS Research.

    PubMed

    James, J S

    1996-05-01

    AIDS advocacy groups won four of the five HIV/AIDS issues on the table in the budget negotiations for fiscal year 1996. Congress and the White House have agreed to increase funding for the Ryan White CARE Act, with the AIDS Drug Assistance Program receiving an increase of $52 million, and an overall $30 million increase for the program. The budget compromise also repeals the law introduced by Congressman Robert Dornan (R-CA) which would have required the military to discharge military personnel living with HIV. Also, the AIDS Education and Training Centers will not be eliminated, although the program will receive cuts. The Housing Opportunities for People with AIDS (HOPWA) is flat funded for fiscal 1996. Negotiations for fiscal 1997 are currently underway. The issue that AIDS advocacy groups lost in the budget negotiation was the consolidated budget authority for the Office of AIDS Research (OAR). On a separate issue, Congress is likely to require states with more than 10 percent of the nation's pediatric AIDS cases to begin mandatory HIV-antibody testing of newborns in 2 years, unless each state can first meet certain standards through voluntary testing programs. Current language in the legislation requires counseling for pregnant women and voluntary HIV testing, measures long advocated by AIDS and public health groups as the best approach for reducing perinatal infection. PMID:11363487

  18. The Epilepsy Spectrum: Targeting Future Research Challenges.

    PubMed

    Holmes, Gregory L; Noebels, Jeffrey L

    2016-01-01

    There have been tremendous recent advances in our understanding of the biological underpinnings of epilepsy and associated comorbidities that justify its representation as a spectrum disorder. Advances in genetics, electrophysiology, and neuroimaging have greatly improved our ability to differentiate, diagnose, and treat individuals with epilepsy. However, we have made little overall progress in preventing epilepsy, and the number of patients who are cured remains small. Likewise, the comorbidities of epilepsy are often underdiagnosed or not adequately treated. In this article, we suggest a few areas in which additional research will likely pay big dividends for patients and their families. PMID:27371672

  19. AIDS research in developing countries: do the ends justify the means?

    PubMed

    Clark, Peter A

    2002-09-01

    Concrete ethical standards for human research are clearly stipulated in both international and national codes of ethics, and are meant to protect human subjects, especially the most vulnerable. A recent clinical study conducted from 1994 to 1997 by Dr. Thomas C, Quinn, M.D. has fueled the debate raging in the scientific community regarding the ethics of clinical AIDS research in developing countries. Quinn's conducted a community-based, randomized, controlled study of 15,127 rural Ugandans to determine whether intermittent antibiotic treatment to reduce the prevalence of other sexually transmitted diseases would also reduce the rate of HIV transmission. Subsequently, the study identified 415 couples in which one partner was HIV positive and one was initially HIV negative and followed them prospectively for up to 30 months. Researchers were not permitted to inform the seronegative partner of the HIV status of the other partner. As a result, 90 of the initially HIV negative partners (21.7%) seroconverted during a follow-up period of 30 months. To allow for research studies in developing countries that are not permitted in the United States appears to make the Third World equivalent to a 'research sweat shop'. Developing nations offer easy access to patients, reduced costs, and less stringent regulations. This appears to create a double standard for medical research that is both ethically and humanly unacceptable, especially when other viable option exist. To allow relativism to seep into the international and national ethical standards will open the door to an idea that condones the possible abuse of those least able to protect themselves. Researchers have an ethical responsibility to uphold the integrity of these ethical standards. Failure to do so today may have a devastating impact on humanity in the future. PMID:12218951

  20. Neurosciences research in space - Future directions

    NASA Technical Reports Server (NTRS)

    Sulzman, Frank M.; Wolfe, James W.

    1991-01-01

    In order to gain a better understanding of the effects of long-duration space missions on the central nervous system, near-term research, to take place from 1990-1995, will be directed at investigating the acute effects of microgravity and the 'space adaptation syndrome'. These include experiments scheduled for the Spacelab Life Sciences 1 which is designed to evaluate changes in the visual, vestibular, and proprioceptive systems. An extensive series of experiments, collectively termed Microgravity Vestibular Investigations (MVI), is also planned for the IML-1 mission to be flown in 1992. The IML-2 mission will emphasize behavior and performance, biological rhythms, and further vestibular studies. Mid-term goals, projected to be achieved from 1995-2000, include the use of new technology such as magnetic recording techniques. Long-term goals are also discussed including studies dealing with neuronal plasticity and sensory substitution, augmentation, and robotic telepresence.

  1. Alcohol research: past, present, and future.

    PubMed

    Gunzerath, Lorraine; Hewitt, Brenda G; Li, Ting-Kai; Warren, Kenneth R

    2011-01-01

    Created forty years ago, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has played a major role in the great strides made in the understanding, treatment, prevention, and public acceptance of alcohol-use disorders. Throughout most of U.S. history "habitual drunkenness" was viewed as a problem of moral degeneracy or character flaw inherent in the individual. However, the wealth of scientific evidence amassed throughout NIAAA's history has established alcoholism as a medical condition, that is, as a disease for which affected individuals should feel no shame or be treated with disdain. We look at the developments in alcohol epidemiology, typology, etiology, prevention, and treatment research over the past 40 years. We also discuss how NIAAA addresses alcohol disorders from a life-course framework, affecting all stages of the lifespan, from fetus through child, adolescent, and young adult, to midlife/senior adult, with each stage involving different risks, consequences, prevention efforts, and treatment strategies. PMID:21182533

  2. Diet and cancer: future etiologic research.

    PubMed Central

    Schatzkin, A; Dorgan, J; Swanson, C; Potischman, N

    1995-01-01

    In light of several credible diet and cancer hypotheses, we suggest strategies for advancing our understanding in this area. Two conceptual approaches can be taken in defining dietary exposure: the decompositional approach focuses on specific nutrients and other chemical constituents of food, whereas the integrative approach emphasizes the action of whole foods or food patterns (cuisines). Diet-cancer hypotheses can be organized according to this conceptual framework. We review four types of scientific investigation available to us for advancing the diet and cancer field: metabolic (clinical nutrition) studies; animal studies; observational epidemiologic investigations; and clinical trials. Each of these designs has its strengths and limitations. Observational epidemiologic studies and trials have the particular advantage of examining explicit cancer end points in humans. Results from metabolic and animal research, however, can complement the findings from epidemiologic studies and trials. Finally, we briefly review strategies for evaluating promising hypotheses linking diet to cancers of the large bowel, lung, breast, and prostate. PMID:8741779

  3. Wildland fire ash: future research directions

    NASA Astrophysics Data System (ADS)

    Bodí, Merche B.; Martins, Deborah A.; Cerdà, Artemi; Balfour, Victoria N.; Santin, Cristina; Doerr, Stefan H.; Pereira, Paulo; Mataix-Solera, Jorge

    2014-05-01

    Ash is a key component of the forest fires affected land (Cerdà, 1998; Bodí et al., 2011; Pereira et al., 2013a). Ash controls the hydrological processes and determines the water repellency (Dlapa et al., 2012) and the infiltration rates (Cerdà and Doerr, 2008;). Moreover, ash is the key factor on runoff initiation and then on the soil erosion. Little is known about the impact of ash in different ecosystems, but during the last decade a substantial increase in the papers that show the role of ash in the Earth and Soil System were published (Bodí et al., 2012; Pereira et al., 2013b).. Ash is being found as the key component of the post-fire pedological, geomorphological and hydrological response after forest fires (Fernández et al., 2012; Martín et al., 2012; Bodí et al., 2013; Guénon et al., 2013; Pereira et al., 2013c). A recent State-of-the-Art review about wildland fire ash (Bodí et al., 2014) compiles the knowledge regarding the production, composition and eco-hydro-geomorphic effects of wildland fire ash. In the present paper we indicate the knowledge gaps detected and suggest topics that need more research effort concerning: i) data collection and analysis techniques: a) To develop standardized sampling techniques that allow cross comparison among sites and avoid inclusion of the underlying soil unless the burned surface soil forms part of the ash layer, b) To develop standardized methods to define and characterize ash, including its color, physical properties such as particle size distribution or density, proportion of pyrogenic C, chemical and biological reactivity and persistence in the environment, c) To validate, calibrate and test measurements collected through remote sensing with on-the-ground measurements. ii) ash production, deposition redistribution and fate: d) To untangle the significance of the effects of maximum temperature reached during combustion versus the duration of heating, e) To understand the production of ash by measuring its

  4. Wildland fire ash: future research directions

    NASA Astrophysics Data System (ADS)

    Bodí, Merche B.; Martins, Deborah A.; Cerdà, Artemi; Balfour, Victoria N.; Santin, Cristina; Doerr, Stefan H.; Pereira, Paulo; Mataix-Solera, Jorge

    2014-05-01

    Ash is a key component of the forest fires affected land (Cerdà, 1998; Bodí et al., 2011; Pereira et al., 2013a). Ash controls the hydrological processes and determines the water repellency (Dlapa et al., 2012) and the infiltration rates (Cerdà and Doerr, 2008;). Moreover, ash is the key factor on runoff initiation and then on the soil erosion. Little is known about the impact of ash in different ecosystems, but during the last decade a substantial increase in the papers that show the role of ash in the Earth and Soil System were published (Bodí et al., 2012; Pereira et al., 2013b).. Ash is being found as the key component of the post-fire pedological, geomorphological and hydrological response after forest fires (Fernández et al., 2012; Martín et al., 2012; Bodí et al., 2013; Guénon et al., 2013; Pereira et al., 2013c). A recent State-of-the-Art review about wildland fire ash (Bodí et al., 2014) compiles the knowledge regarding the production, composition and eco-hydro-geomorphic effects of wildland fire ash. In the present paper we indicate the knowledge gaps detected and suggest topics that need more research effort concerning: i) data collection and analysis techniques: a) To develop standardized sampling techniques that allow cross comparison among sites and avoid inclusion of the underlying soil unless the burned surface soil forms part of the ash layer, b) To develop standardized methods to define and characterize ash, including its color, physical properties such as particle size distribution or density, proportion of pyrogenic C, chemical and biological reactivity and persistence in the environment, c) To validate, calibrate and test measurements collected through remote sensing with on-the-ground measurements. ii) ash production, deposition redistribution and fate: d) To untangle the significance of the effects of maximum temperature reached during combustion versus the duration of heating, e) To understand the production of ash by measuring its

  5. Acamprosate: recent findings and future research directions.

    PubMed

    Mann, Karl; Kiefer, Falk; Spanagel, Rainer; Littleton, John

    2008-07-01

    This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism. New evidence at the molecular and cellular level suggests that acamprosate attenuates hyper-glutamatergic states that occur during early abstinence and involves iono (NMDA)- and metabotrotropic (mGluR5) glutamate receptors along with augmented intracellular calcium release and electrophysiological changes. Thus mutant mice with enhanced glutamate levels exhibit higher alcohol consumption than wild type mice and respond better to acamprosate, demonstrating that acamprosate acts mainly on a hyper-glutamatergic system. This mode of action further suggests that acamprosate exhibits neuroprotective properties. In rats, cue-induced reinstatement behavior is significantly reduced by acamprosate treatment whereas cue-induced craving responses in alcohol-dependent patients seem not to be affected by this treatment. An ongoing study ("Project Predict") defines specific responder profiles for an individualized use of acamprosate and naltrexone. Neurophysiological as well as psychometric data are used to define 2 groups of patients: "reward cravers" and "relief cravers". While naltrexone should work better in the first group, acamprosate is hypothesized to be efficacious in the latter where withdrawal associated and/or cue induced hyper-glutamatergic states are thought to trigger relapse. Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy. PMID:18540918

  6. Research on AIDS: knowledge, attitudes and practices among street youth.

    PubMed

    Barker, G

    1993-01-01

    CHILDHOPE (with funding from the United Nations Children's Fund and the aid of nongovernmental organizations in the Philippines, Thailand, Colombia, and Kenya) conducted surveys of street youth in order to ascertain their knowledge, attitudes, and practices in regard to sex and the prevention of human immunodeficiency virus (HIV) infections and other sexually transmitted diseases (STDs). The youth also participated in acquired immunodeficiency syndrome (AIDS) prevention and sex education activities. Youth from all 4 sites reported early sexual activity and multiple partners. Sex was used in all 4 sites to obtain pleasure (recreation), income (prostitution), food or shelter (survival sex), and power (gang rape). Philippine youth reported prostitution and survival sex, including homosexual sex, with foreigners and locals. Kenyan girls reported both prostitution (their main occupation) and survival sex. Kenyan males reported prostitution with foreigners and locals, and rapes of girls. In Bogota, males reported rapes of girls, and gang rapes of females for punishment or initiation. They also reported using sex workers and exchanging sex with men or women for food and shelter. Females from Bogota reported that their "friends" sometimes used survival sex to support their children; nearly all had been previously involved in survival sex on the street. Sexual abuse was common in Kenya and the Philippines; some youth in Manila were abused at shelters. In all 4 sites, there was a high awareness of AIDS and STDs, but information was often incorrect, especially in regard to transmission and treatment of STDs. Although nearly all of the youth knew about modes of transmission of HIV, those from the Philippines and Colombia did not have a personal realization or fear that they could contract it, while those from Kenya and Thailand believed they were at high risk and wanted assistance. 20/21 Kenyan girls were tested by the Undugu Society for HIV after detection of current STD

  7. Race and Child Welfare Services: Past Research and Future Directions.

    ERIC Educational Resources Information Center

    Courtney, Mark E.; And Others

    1996-01-01

    Reviews child welfare research studies and discusses empirical literature on relationships among race, services, and outcomes in selected child welfare domains. Provides summary of previous research. Presents conceptual and methodological considerations for future research on role of race in child welfare and development of culturally competent…

  8. Special Education Teacher Education Research: Current Status and Future Directions

    ERIC Educational Resources Information Center

    Sindelar, Paul T.; Brownell, Mary T.; Billingsley, Bonnie

    2010-01-01

    In this article, the authors propose an agenda for special education teacher education researchers, with particular attention to policy work and studies of innovations in pre-service preparation, induction and mentoring, and professional development. Because previous research is limited and unfocused, the foundation for future research is weak,…

  9. Directions for Future Research in Vocational Special Needs Education.

    ERIC Educational Resources Information Center

    Rojewski, Jay W.; Meers, Gary D.

    A two-phase empirical investigation identified, categorized, and prioritized research needs in vocational special education for the next 10 years. Phase 1 involved 18 university personnel in a three-round Delphi technique that generated 91 future research objectives. Research statements collected from Round 1 questionnaires were used to construct…

  10. Prospects for Technical Communication: Research for Futures Needs.

    ERIC Educational Resources Information Center

    Mathes, J. C.

    The need for technical communication to enable the transition from a "postindustrial" future to an alternative future is incalculable; however, research is required to improve current technical communication models and methods. The current rhetoric of technical communication derives from an inadequate command-generated technical communication…

  11. Science and cycling: current knowledge and future directions for research.

    PubMed

    Atkinson, Greg; Davison, Richard; Jeukendrup, Asker; Passfield, Louis

    2003-09-01

    In this holistic review of cycling science, the objectives are: (1) to identify the various human and environmental factors that influence cycling power output and velocity; (2) to discuss, with the aid of a schematic model, the often complex interrelationships between these factors; and (3) to suggest future directions for research to help clarify how cycling performance can be optimized, given different race disciplines, environments and riders. Most successful cyclists, irrespective of the race discipline, have a high maximal aerobic power output measured from an incremental test, and an ability to work at relatively high power outputs for long periods. The relationship between these characteristics and inherent physiological factors such as muscle capilliarization and muscle fibre type is complicated by inter-individual differences in selecting cadence for different race conditions. More research is needed on high-class professional riders, since they probably represent the pinnacle of natural selection for, and physiological adaptation to, endurance exercise. Recent advances in mathematical modelling and bicycle-mounted strain gauges, which can measure power directly in races, are starting to help unravel the interrelationships between the various resistive forces on the bicycle (e.g. air and rolling resistance, gravity). Interventions on rider position to optimize aerodynamics should also consider the impact on power output of the rider. All-terrain bicycle (ATB) racing is a neglected discipline in terms of the characterization of power outputs in race conditions and the modelling of the effects of the different design of bicycle frame and components on the magnitude of resistive forces. A direct application of mathematical models of cycling velocity has been in identifying optimal pacing strategies for different race conditions. Such data should, nevertheless, be considered alongside physiological optimization of power output in a race. An even distribution

  12. Building a Better Bibliography: Computer-Aided Research Tools.

    ERIC Educational Resources Information Center

    Bloomfield, Elizabeth

    1989-01-01

    Describes a project at the University of Guelph (Ontario) that combined both bibliographical and archival references in one large machine readable database to facilitate local history research. The description covers research tool creation, planning activities, system design, the database management system used, material selection, record…

  13. New Animal Model Could Boost Research on AIDS Drugs and Vaccines | Poster

    Cancer.gov

    By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer In a research milestone reported in the June 20 issue of the journal Science, scientists have developed a minimally modified version of HIV-1, the virus that causes AIDS in infected humans, that is capable of causing progressive infection and AIDS in monkeys. The advance should help create more authentic animal models of the disease and provide a potentially invaluable approach for faster and better preclinical evaluation of new drugs and vaccines.

  14. The national- and international-wide prospects of future improvements of position location and time synchronization systems and aids

    NASA Technical Reports Server (NTRS)

    Gouzhva, Yuri G.; Balyasnikov, Boris N.; Korniyenko, Vladimir V.; Pushkina, Irina G.; Shebshayevich, Valentin S.; Denisov, Vladimir I.; Reutov, Alexander P.

    1990-01-01

    The concept being designed by the Leningrad Scientific Research Radio Technical Institute (LSRRI) of united positioning and timing service on the basis of the utilization of long-range and global radionavigation and common time systems and aids for different users is described. The estimate of its utilization on the national as well as on international scale is given.

  15. Focusing National Institutes of Health HIV/AIDS Research for Maximum Population Impact

    PubMed Central

    Walensky, Rochelle P.; Auerbach, Judith D.; Carpenter, Charles J.; Auerbach, Judith D.; Agosto-Rosario, Moisés; Averitt, Dawn; Bartlett, John G.; Curran, James W.; DiClemente, Ralph J.; El-Sadr, Wafaa; Haase, Ashley; Hillier, Sharon; Holmes, King K.; Volberding, Paul A.; Walensky, Rochelle P.

    2015-01-01

    Progress in advancing research on the pathophysiology, prevention, treatment, and impact of human immunodeficiency virus (HIV) is threatened by the decaying purchasing power of National Institutes of Health (NIH) dollars. A working group of the NIH Office of AIDS Research Advisory Council was charged by the NIH Director with developing a focused and concise blueprint to guide the use of limited funding over the next few years. Science priorities outlined by the working group and reported here are intended to maximally address individuals, groups, and settings most affected by the epidemic, and to redress shortcomings in realizing population-level HIV prevention, treatment, and eradication goals. Optimizing these priorities requires that traditional silos—defined by topic focus and by scientific discipline—be dissolved and that structural issues affecting the pipeline of new investigators and the ability of the Office of AIDS Research to fulfill its role of steward of the NIH HIV/AIDS research program be directly addressed. PMID:25422391

  16. Focusing National Institutes of Health HIV/AIDS research for maximum population impact.

    PubMed

    Walensky, Rochelle P; Auerbach, Judith D

    2015-03-15

    Progress in advancing research on the pathophysiology, prevention, treatment, and impact of human immunodeficiency virus (HIV) is threatened by the decaying purchasing power of National Institutes of Health (NIH) dollars. A working group of the NIH Office of AIDS Research Advisory Council was charged by the NIH Director with developing a focused and concise blueprint to guide the use of limited funding over the next few years. Science priorities outlined by the working group and reported here are intended to maximally address individuals, groups, and settings most affected by the epidemic, and to redress shortcomings in realizing population-level HIV prevention, treatment, and eradication goals. Optimizing these priorities requires that traditional silos--defined by topic focus and by scientific discipline--be dissolved and that structural issues affecting the pipeline of new investigators and the ability of the Office of AIDS Research to fulfill its role of steward of the NIH HIV/AIDS research program be directly addressed. PMID:25422391

  17. Big Ideas for the Future: UK Research That Will Have a Profound Effect on Our Future

    ERIC Educational Resources Information Center

    Universities UK, 2011

    2011-01-01

    Big ideas for the future is a joint report by Universities UK and Research Councils UK, published as part of the second annual Universities Week campaign. This new report explores the excellent research taking place in UK higher education today and what it will mean for us in 20 years' time. It demonstrates the value of public investment in higher…

  18. A systematic review of HIV/AIDS-related stigma and discrimination in India: current understanding and future needs.

    PubMed

    Bharat, Shalini

    2011-01-01

    HIV/AIDS-related stigma is recognised as a major barrier to HIV prevention efforts and an impediment to mitigating its impact on individuals and communities. This paper reviews the existing research literature on AIDS stigma in India with the objective of documenting the current status of research, highlighting major findings and identifying key gaps remaining. Thirty publications were identified through a careful search of which a majority focused on stigma assessment and very few on stigma measurement, conceptual aspects of stigma or stigma reduction interventions. A few standardised stigma measures are available but more are required to assess causes of stigma among general population and compounded and internalised stigma among positive people. Research exploring linkages between stigma and HIV services uptake or the effect of HIV care and treatment programs on stigma levels are largely missing and need to be prioritised. In addition, more research is needed to advance conceptual understanding of stigma within the cultural context of the country including research on the neglected groups such as, transgender people. Context-specific (health care, community) interventions are needed to address various forms of stigma - enacted, perceived, internalised and layered - including structural approaches besides inter-personal and information-based approaches. A major gap relates to meager research on developing and evaluating stigma reduction interventions and needs priority focus. Overall, the review recommends developing a national agenda on AIDS stigma research and interventions to help realise the government's goal of stigma reduction. PMID:23237728

  19. Future Secretariat: an innovation research coordination and governance structure

    NASA Astrophysics Data System (ADS)

    Ojima, D. S.; Johan, R.; Cramer, W.; Fukushi, K.; Allard, S.

    2014-12-01

    Future Earth, an emerging global sustainability research program, will be managed by a novel, internationally distributed secretariat spanning the globe and providing a platform for co-design, co-production, and co-delivery of knowledge to support research on the earth system, global development and transformation toward sustainability. The Future Earth secretariat has an innovative structure consisting of five global hubs functioning as a single entity; these hubs are located in Canada, Japan, France, Sweden, and the United States. The secretariat's reach is extended through a set of regional hubs covering Latin America, the Middle East, Africa, Europe, and Asia, with the potential to expand to additional areas. This secretariat will operate under the auspices of the Future Earth Governing Council The Future Earth Secretariat will support and enable the implementation of knowledge-sharing between research and stakeholder communities to enable society to cope with and to alter global environmental trends, and to transition society toward sustainability. The secretariat will provide coordination support to over 25 global environmental core projects and committees; coordinate scientific work across the whole Future Earth agenda; develop and implement innovative mechanisms for bottom-up inputs, synthesis and integration. Future Earth, as a research program, aims to support global transformations toward sustainability through partnerships among scientific and stakeholder communities worldwide. It brings together existing international environmental research core projects associated with DIVERSITAS, the International Geosphere-Biosphere Programme, the International Human Dimensions Programme, and the World Climate Research Programme—to support coordinated, interdisciplinary research that can be used by decision makers seeking to reduce their impact and provide more sustainable products and services. USGCRP partners with Future Earth through scientific participation in

  20. The Evolution and Future of Cognitive Research in Music.

    ERIC Educational Resources Information Center

    Taylor, Jack A.

    1993-01-01

    Discusses the evolution and current status of cognitive research in music. Identifies the field's five research branches: (1) sensation; (2) perception; (3) concept formation and memory; (4) affect or emotions; and (5) psychomotor activity. Recommends five changes for the future of cognitive musicology. (CFR)

  1. Current status and future research in motion planning

    SciTech Connect

    Hwang, Y.K.

    1995-07-01

    There have been numerous research efforts in the field of motion planning, resulting in many theoretical and practical results. We review the current status of existing motion planning algorithms, evaluate their completeness and efficiencies on modern computers, and suggest fruitful future research directions.

  2. Research in Inertial Fusion Sciences: Now and in the Future

    SciTech Connect

    Powell, H T; Campbell, E M; Hogan, W J; Orth, C D

    2001-04-10

    We review the current and future state of research in inertial fusion sciences. We describe the National Ignition Facility (NIF), the IFE development plan, applications of inertial confinement fusion (ICF) to various high-energy sciences, uses of petawatt laser systems, and concepts for the ICF integrated research experiment (IRE) and IFE power plants.

  3. Official Language Bilingualism for Allophones in Canada: Exploring Future Research

    ERIC Educational Resources Information Center

    Mady, Callie; Turnbull, Miles

    2012-01-01

    This article offers a review of policy and research as they relate to Allophones and their access to French Second Official Language (FSOL) programs in English-dominant Canada. Possible areas of future research are woven throughout the review as questions emerge in the summary of relevant literature. (Contains 3 notes.)

  4. An Exploration of Future Trends in Environmental Education Research

    ERIC Educational Resources Information Center

    Ardoin, Nicole M.; Clark, Charlotte; Kelsey, Elin

    2013-01-01

    This article describes future trends in environmental education (EE) research based on a mixed-methods study where data were collected through a content analysis of peer-reviewed articles published in EE journals between 2005 and 2010; interviews with experts engaged in EE research and sustainability-related fields; surveys with current EE…

  5. Mass Communication Research; Major Issues and Future Directions.

    ERIC Educational Resources Information Center

    Davison, W. Phillips, Ed.; Yu, Frederick T. C., Ed.

    The papers in this edited volume on the directions in mass communication research deal with two broad questions: What is the current state of knowledge with respect to the area in question? And what might be the most fruitful directions for future research? The nine articles include: (1) an attempt to structure the field of mass communication; (2)…

  6. Presidential Address: Culture and the Future of Education Research

    ERIC Educational Resources Information Center

    Halse, Christine

    2013-01-01

    Recent changes in higher education have confronted education research with a conundrum: how our traditionally multidisciplinary field can refine itself as a unified discipline. In this address I sketch out what this conundrum may mean for education research, both substantively and methodologically, in the future. I propose that one starting point…

  7. Research and reform are priorities for South Africa's new AIDS chiefs.

    PubMed

    Hambridge, M

    1995-06-01

    Beginning her political career as vice-president of the South Africa Students' Organization, Dr. Nkosazana Zuma has recently been appointed Minister of Health of South Africa. Zuma's appointment reflects her prominent role as an African National Congress (ANC) activist during apartheid, as well as her solid credentials and qualifications for the position. Dr. Zuma has been Director of the Health Refugee Trust, a scientist focused mainly upon AIDS at the Medical Research Council, and head of the ANC Women's League in Southern Natal over the period 1991-94. South African President Nelson Mandela has charged her with restructuring a fragmented and mainly urban-based health system so that all South Africans have access to affordable health care. To that end, Minister Zuma has thus far introduced free health care for children under six and for pregnant women, and a primary school nutrition scheme expected to reach four million children. AIDS has been given high priority. A National AIDS Plan has been adopted with regions given help in developing implementation plans. More money as well as private-public sector collaboration are, however, needed to accomplish the goals of the National Plan. Quarraisha Abdool Karim was appointed in January 1995 by Minister Zuma as the first National AIDS Director of the new South Africa. She is committed to reforming the health system and using intervention-based research as the main tool of change. Karim's extensive background in AIDS research, her involvement in the development of the National AIDS Plan, and her reputation as a campaigner for health reform make her an ideal candidate for the job. She helped draft the national AIDS strategy designed to meet the needs of women, and in 1991 helped establish an AIDS plan for KwaZulu/Natal which was subsequently integrated into the National AIDS Committee of South Africa (NACOSA). Karim's research has earned international acclaim. Among others, she also received a grant from the US National

  8. Research Agenda: Priorities for Future Research in Second Language Assessment

    ERIC Educational Resources Information Center

    Stoynoff, Stephen

    2012-01-01

    In a recent state-of-the-art (SoA) article (Stoynoff 2009), I reviewed some of the trends in language assessment research and considered them in light of validation activities associated with four widely used international measures of L2 English ability. This Thinking Allowed article presents an opportunity to revisit the four broad areas of L2…

  9. Relational Inquiries and the Research Interview: Mentoring Future Researchers

    ERIC Educational Resources Information Center

    Hoskins, Marie L.; White, Jennifer

    2013-01-01

    In this article we describe some of the challenges and constraints that students face when they engage in qualitative research interviews. We borrow extensively from Ron Pelias' in-depth description of "leaning in" during everyday life encounters. Although he refers to other kinds of relationships, we believe that the similarities…

  10. HIV/AIDS Research in Correctional Settings: A Difficult Task Made Even Harder?

    PubMed Central

    Johnson, Mark E.; Kondo, Karli K.; Eldridge, Gloria D.

    2015-01-01

    Housing a large number of individuals living with or at risk for HIV/AIDS, correctional settings have considerable potential for epidemiological, prevention, and treatment research. However, federal regulations and institutional challenges have limited the extent and types of such research with prisoners. This study examines the degree to which HIV/AIDS correctional researchers report greater challenges than do their non-correctional counterparts. Results indicated that correctional researchers reported significantly more frequent challenges than those in noncorrectional settings, even after controlling for experience; with the dominant difference related to challenges due to the research setting. These findings add empirical data and support previous research in the field; however, additional research should include correctional staff and incarcerated individuals, and explore whether these differences extend to other research topics. PMID:25788606

  11. HIV/AIDS Research in Correctional Settings: A Difficult Task Made Even Harder?

    PubMed

    Johnson, Mark E; Kondo, Karli K; Brems, Christiane; Eldridge, Gloria D

    2015-04-01

    Housing a large number of individuals living with or at risk for HIV/AIDS, correctional settings have considerable potential for epidemiological, prevention, and treatment research. However, federal regulations and institutional challenges have limited the extent and types of such research with prisoners. This study examines the degree to which HIV/AIDS correctional researchers report greater challenges than do their noncorrectional counterparts. Results indicate that correctional researchers reported significantly more frequent challenges than those in noncorrectional settings, even after controlling for experience, with the dominant difference related to challenges due to the research setting. These findings add empirical data and support previous research in the field; however, additional research should include correctional staff and incarcerated individuals, and explore whether these differences extend to other research topics. PMID:25788606

  12. Clinical Research Informatics: Recent Advances and Future Directions

    PubMed Central

    2015-01-01

    Summary Objectives To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions. Methods Survey of advances, open problems and opportunities in this field based on exploration of current literature. Results Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/recruitment and clinical trial execution. Discussion CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI. PMID:26293865

  13. Languaging for Life: African Youth Talk Back to HIV/AIDS Research

    ERIC Educational Resources Information Center

    Norton, Bonny; Mutonyi, Harriet

    2010-01-01

    In this article, we present a case study, undertaken in Uganda, in which 12 young people debated and critiqued four research articles on HIV/AIDS relevant to Ugandan youth. The rationale for the study was to provide students with the opportunity to respond to health research that had a direct bearing on their lives. It also complements applied…

  14. Impact of Visual Aids in Enhancing the Learning Process Case Research: District Dera Ghazi Khan

    ERIC Educational Resources Information Center

    Shabiralyani, Ghulam; Hasan, Khuram Shahzad; Hamad, Naqvi; Iqbal, Nadeem

    2015-01-01

    This research explores teachers' opinions on the use of visual aids (e.g., pictures, animation videos, projectors and films) as a motivational tool in enhancing students' attention in reading literary texts. To accomplish the aim of the research, a closed ended questionnaire was used to collect the required data. The targeted population for this…

  15. Social science research on HIV in Vietnam: a critical review and future directions.

    PubMed

    Dao, Amy; Hirsch, Jennifer S; Giang, Le Minh; Parker, Richard G

    2013-01-01

    Social science research can enhance the response to Vietnam's growing HIV epidemic by capturing the country's rapidly changing social and political context. The present paper reviews the published, peer-reviewed and English-language social science literature on HIV in Vietnam in order to identify critical theoretical and substantive gaps, while laying the groundwork for future research. We found four broad foci for work on the social context of HIV and AIDS in Vietnam: the cultural meanings and social relationships that shape Vietnam's HIV epidemic; stigma and discrimination; social inequality and structural violence as contributors to HIV risk; and, finally, how broader global and social systems shape Vietnam's HIV epidemic. We signal the particular need for additional research on the effects of the media on attitudes towards HIV and AIDS, on social movements, and on health systems, as well as on a number of other key areas. Work along these lines, in addition to more effective communication of policy-relevant findings to those responsible for the development and implementation of policies and programmes, will strengthen Vietnam's response to HIV and AIDS. PMID:23906241

  16. Social science research of HIV in Vietnam: A critical review and future directions

    PubMed Central

    Dao, Amy; Hirsch, Jennifer; Giang, Le Minh; Parker, Richard G.

    2013-01-01

    Social science research, with theoretical and methodological tools that are well suited to capture the complexities of Vietnam’s rapidly changing social and political context, could contribute important insights that would enhance the response to Vietnam’s growing HIV epidemic. The present paper reviews the published, peer-reviewed English-language social science literature on HIV in Vietnam in order to identify critical theoretical and substantive gaps and lay the groundwork for future research. We found four broad foci for work on the social context of HIV and AIDS in Vietnam: the cultural meanings and social relationships that shape Vietnam’s HIV epidemic; stigma and discrimination; social inequality and structural violence as contributors to HIV risk; and, finally, how broader global and social systems shape Vietnam’s HIV epidemic. We signal the particular need for additional research on the effects of the media on attitudes toward HIV and AIDS, on social movements, and on health systems, as well as on a number of other key areas. Work along these lines, in addition to more effective communication of policy-relevant findings to those responsible for the development and implementation of policies and programmes, will strengthen Vietnam’s response to HIV and AIDS. PMID:23906241

  17. Cold Fronts Research Programme: Progress, Future Plans, and Research Directions.

    NASA Astrophysics Data System (ADS)

    Ryan, B. F.; Wilson, K. J.; Garratt, J. R.; Smith, R. K.

    1985-09-01

    Following the analysis of data collected during Phases land II of the Cold Fronts Research Programme (CFRP) a conceptual model for the Australian summertime "cool change" has been proposed. The model provides a focus and a framework for the design of Phase III.The model is based on data gathered from a mesoscale network centered on Mount Gambier, South Australia, and includes the coastal waters to the west and relatively flat terrain to the east. The first objective of Phase III is to generalize the model so that it is applicable to the ocean waters to the far west of Mount Gambier and to the more rugged terrain farther to the east in the vicinity of Melbourne, Victoria. The remaining objectives concentrate on resolving unsatisfactory aspects of the model such as the evolution of convective lines and the relationship between the surface cold front and the upper-tropospheric cold pool and its associated jet stream.The integrated nature of the Cold Fronts Research Programme has meant that it has stimulated a wide range of research activities that extend beyond the field observations. The associated investigations include climatological, theoretical, and numerical modeling studies.

  18. Suffering, silence, and status: the importance and challenges of qualitative research on AIDS orphanhood.

    PubMed

    Cheney, Kristen E

    2015-01-01

    Drawing on ethnographic fieldwork with Ugandan children affected by AIDS conducted from 2007 to 2014, this report summarizes findings of a study conducted to better understand the ways children experience orphanhood at the hands of HIV/AIDS. Three crucial, interrelated concepts emerged: suffering, silence, and status. This study explored the social context of AIDS orphanhood as both a cause of social suffering and a context for the suffering of individual children. Though problematic, silence about suffering is often due to continuing HIV/AIDS stigma in Uganda that makes one's status unspeakable, in spite of the adverse effect this has on the social order and efforts to eradicate the disease. Approaching silence as a distinct form of communication rather than an absence of it, the report considers silence's intergenerational functions, its detriments, and its consolations, in the context of HIV/AIDS-affected children's lives. In doing so, it also highlights the need for more child-centered, qualitative research on AIDS' psychosocial effects on children, despite the challenges of doing such research. PMID:25297723

  19. "Clustering" as an Aid in Guidance, Counselling, and Related Research.

    ERIC Educational Resources Information Center

    Carney, T. F.

    1992-01-01

    The technique of clustering facilitates constructivist investigation in counseling research and clinical counseling sessions. Clients can be helped to put difficult-to-verbalize feelings into words. Having clients collaborate in configuring the rich but chaotic data renders that data amenable to matrix analysis. Recently developed computer…

  20. Data Quality in web-based HIV/AIDS research: Handling Invalid and Suspicious Data

    PubMed Central

    Bauermeister, Jose; Pingel, Emily; Zimmerman, Marc; Couper, Mick; Carballo-Diéguez, Alex; Strecher, Victor J.

    2011-01-01

    Invalid data may compromise data quality. We examined how decisions taken to handle these data may affect the relationship between Internet use and HIV risk behaviors in a sample of young men who have sex with men (YMSM). We recorded 548 entries during the three-month period, and created 6 analytic groups (i.e., full sample, entries initially tagged as valid, suspicious entries, valid cases mislabeled as suspicious, fraudulent data, and total valid cases) using data quality decisions. We compared these groups on the sample’s composition and their bivariate relationships. Forty-one cases were marked as invalid, affecting the statistical precision of our estimates but not the relationships between variables. Sixty-two additional cases were flagged as suspicious entries and found to contribute to the sample’s diversity and observed relationships. Using our final analytic sample (N = 447; M = 21.48 years old, SD = 1.98), we found that very conservative criteria regarding data exclusion may prevent researchers from observing true associations. We discuss the implications of data quality decisions and its implications for the design of future HIV/AIDS web-surveys. PMID:23180978

  1. Disclosure of an HIV diagnosis to Children: History, Current Research, and Future Directions

    PubMed Central

    Wiener, Lori; Mellins, Claude Ann; Marhefka, Stephanie; Battles, Haven B.

    2008-01-01

    Disclosing the diagnosis of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) to a child is a controversial and emotionally charged issue amongst both the health care communities and parents and caregivers of these children. This paper provides a systematic review of research on disclosure of pediatric HIV infection. The paper begins with a brief discussion of disclosure drawing from research on pediatric cancer. Next, we review the available research including patterns of disclosure, factors associated with disclosure and non-disclosure, and the effect of disclosure on psychological health and adherence. A review of published intervention studies is also included. While no consensus on when the diagnosis of HIV should be disclosed to a child or the psychological outcomes associated with disclosure was found, clinical consensus on several issues related to working with families was identified. We apply this literature to clinical practice and suggest avenues and directions for future research. PMID:17435473

  2. The Future of Qualitative Research in Psychology: Accentuating the Positive.

    PubMed

    Gough, Brendan; Lyons, Antonia

    2016-06-01

    In this paper we reflect on current trends and anticipate future prospects regarding qualitative research in Psychology. We highlight various institutional and disciplinary obstacles to qualitative research diversity, complexity and quality. At the same time, we note some causes for optimism, including publication breakthroughs and vitality within the field. The paper is structured into three main sections which consider: 1) the positioning of qualitative research within Psychology; 2) celebrating the different kinds of knowledge produced by qualitative research; and 3) implementing high quality qualitative research. In general we accentuate the positive, recognising and illustrating innovative qualitative research practices which generate new insights and propel the field forward. We conclude by emphasising the importance of research training: for qualitative research to flourish within Psychology (and beyond), students and early career researchers require more sophisticated, in-depth instruction than is currently offered. PMID:26179872

  3. Prevention Interventions with Persons Living with HIV/AIDS: State of the Science and Future Directions

    ERIC Educational Resources Information Center

    Gordon, Christopher M.; Forsyth, Andrew D.; Stall, Ron; Cheever, Laura W.

    2005-01-01

    The National Institutes of Health (NIH/NIMH), the Centers for Disease Control and Prevention (CDC), and the HIV/AIDS Bureau of the Health Resources and Services Administration (HRSA) support the CDC's Serostatus Approach to Fighting the HIV Epidemic (SAFE; Janssen et al., 2001). One aim of the strategy is to help individuals living with HIV (and…

  4. Future buildings Forum-2025: Toward a methodology for future buildings research

    SciTech Connect

    Briggs, R.S.

    1990-10-01

    The purpose of this paper is to explore methods that could be used in studying buildings of the future. The methodology that the forum will develop will have a number of likely applications, among them: the development of research agendas for new building energy technologies; the development of information and analytical capabilities usable by other IEA annexes to address their technology assessment needs; and the generation of information that can serve as input to global energy models designed to inform energy policy decisions. This paper is divided into two major sections. The first is an overview of existing methods of futures research. Terms and concepts are explained, providing the basis for the second section. The second section proposes a framework and general methodology for studying future buildings. This preliminary, or strawman, methodology is intended to provoke early thinking and discussions on how the research should be approached. 24 refs., 8 figs.

  5. Structural dynamics technology research in NASA: Perspective on future needs

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The perspective of a NASA ad hoc study group on future research needs in structural dynamics within the aerospace industry is presented. The common aspects of the design process across the industry are identified and the role of structural dynamics is established through a discussion of various design considerations having their basis in structural dynamics. The specific structural dynamics issues involved are identified and assessed as to their current technological status and trends. Projections of future requirements based on this assessment are made and areas of research to meet them are identified.

  6. $200,000 Grants Awarded to CCR Researchers for HIV/AIDS Studies | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Earlier this year, the Office of AIDS Research (OAR) awarded two, two-year grants of $200,000 each to Anu Puri, Ph.D., and Robert Blumenthal, Ph.D., both of the Center for Cancer Research (CCR) Nanobiology Program, and to Eric Freed, Ph.D., of the HIV Drug Resistance Program, for their research on potential new treatments for HIV.

  7. Leaders, leadership and future primary care clinical research

    PubMed Central

    Furler, John; Cleland, Jennifer; Del Mar, Chris; Hanratty, Barbara; Kadam, Umesh; Lasserson, Daniel; McCowan, Colin; Magin, Parker; Mitchell, Caroline; Qureshi, Nadeem; Rait, Greta; Steel, Nick; van Driel, Mieke; Ward, Alison

    2008-01-01

    Background A strong and self confident primary care workforce can deliver the highest quality care and outcomes equitably and cost effectively. To meet the increasing demands being made of it, primary care needs its own thriving research culture and knowledge base. Methods Review of recent developments supporting primary care clinical research. Results Primary care research has benefited from a small group of passionate leaders and significant investment in recent decades in some countries. Emerging from this has been innovation in research design and focus, although less is known of the effect on research output. Conclusion Primary care research is now well placed to lead a broad re-vitalisation of academic medicine, answering questions of relevance to practitioners, patients, communities and Government. Key areas for future primary care research leaders to focus on include exposing undergraduates early to primary care research, integrating this early exposure with doctoral and postdoctoral research career support, further expanding cross disciplinary approaches, and developing useful measures of output for future primary care research investment. PMID:18822178

  8. Research in paediatric neuropsychology--past, present and future.

    PubMed

    Frampton, Ian

    2004-01-01

    Reviews of the research literature in a range of neurodevelopmental disorders and acquired brain injury reveal a remarkably consistent historical transition through three phases, here termed structural, theoretical and dynamic neuropsychology. Of course, any attempt to summarize such a complex and rich history using a simplistic heuristic will inevitably fail to capture the wide diversity of the research effort. Nevertheless, it is argued that looking at three distinct phases in the history of research helps to organize the field and points to possible future directions for applied research. Using examples from an eclectic range of disorders including childhood obsessive compulsive disorder, congenital hemiplegia and disorders implicating mutation of neurodevelopmental control genes, the implications for future efforts in paediatric neurorehabilitation are considered. PMID:14744672

  9. Workplace discrimination and HIV/AIDS: the national EEOC ADA research project.

    PubMed

    Conyers, Liza; Boomer, K B; McMahon, Brian T

    2005-01-01

    This article utilizes data from the Equal Employment Opportunity Commission's Integrated Mission System database to document the levels of employment discrimination involving individuals with HIV/AIDS. The researchers explore the theory that the nature of HIV/AIDS related employment discrimination is rooted in deeper stigmatization than discrimination against other disability groups. Researchers compare and contrast key demographic characteristics of Charging Parties and Respondents involved in HIV/AIDS related allegations of discrimination and their proportion of EEOC merit resolutions to those of persons with other physical, sensory, and neurological impairments. Findings indicate that, in contrast to the general disability group, HIV/AIDS was more likely to be male, ethnic minorities, between the ages of 25-44, in white collar jobs, in the South and West and to work for businesses with 15 to 100 employees. Additionally, the allegations in HIV/AIDS were more likely to receive merit resolution from the EEOC by a large difference of ten percent. PMID:16006674

  10. Communicative Language Testing: Current Issues and Future Research

    ERIC Educational Resources Information Center

    Harding, Luke

    2014-01-01

    This article discusses a range of current issues and future research possibilities in Communicative Language Testing (CLT) using, as its departure point, the key questions which emerged during the CLT symposium at the 2010 Language Testing Forum. The article begins with a summary of the 2010 symposium discussion in which three main issues related…

  11. The Study of the Future: An Agenda for Research.

    ERIC Educational Resources Information Center

    Boucher, Wayne I., Ed.

    This collection of 18 papers is concerned with the beliefs, methods, practices, and results associated with the type of forecasting which has become known in the last 10 to 15 years as "futures research." Topics discussed include: (1) forecasting methodology; (2) the validity of forecasting systems; (3) unforeseen developments; (4) forecasting in…

  12. Tuberous Sclerosis Complex: A Roadmap for Future Research.

    PubMed

    Jeong, Anna

    2016-07-01

    Investigators from the NINDS and the Tuberous Sclerosis Alliance sponsored a workshop in March 2015, which joined basic scientists and clinicians with expertise in various aspects of Tuberous Sclerosis Complex (TSC), in order to assess the current state of TSC research and to set future goals. PMID:27617567

  13. Educational Imperatives of the Future Research Library: A Symposium.

    ERIC Educational Resources Information Center

    Woodsworth, Anne; And Others

    1991-01-01

    Seven articles discuss the competencies needed by library and information science school graduates. Surveys of needed competencies are compared, a model of the information activities of a research library of the future is proposed, staffing and educational requirements are discussed, and a need for new philosophies of user services is suggested.…

  14. Conclusions, Reflections, and Prospects for Future Research, Policy, and Programming

    ERIC Educational Resources Information Center

    Clark-Kazak, Christina

    2012-01-01

    This concluding chapter draws together some of the key themes from the contributions and proposes some recommended areas for future research, policy, and programming. It highlights the artificiality of categorization processes related to both migration and childhood that independent child migrants encounter, and problematizes the…

  15. Transforming the Future of Learning with Educational Research

    ERIC Educational Resources Information Center

    Askell-Williams, Helen, Ed.

    2015-01-01

    The field of education is a vital component of today's society, enriching and facilitating the attainment of new knowledge. Progress continues to be achieved in this area as new methods are envisioned that increase education's value. "Transforming the Future of Learning with Educational Research" brings together diverse perspectives that…

  16. The tau and beyond: Future research on heavy leptons

    SciTech Connect

    Perl, M.I.

    1988-01-01

    This paper outlines directions for future experimental research on the tau and tau neutrino. Present limits on the existence of heavier charged leptons are reviewed, with emphasis on the close-mass lepton pair concept. 44 refs., 8 figs., 5 tabs.

  17. A Multidisciplinary Research Team Approach to Computer-Aided Drafting (CAD) System Selection. Final Report.

    ERIC Educational Resources Information Center

    Franken, Ken; And Others

    A multidisciplinary research team was assembled to review existing computer-aided drafting (CAD) systems for the purpose of enabling staff in the Design Drafting Department at Linn Technical College (Missouri) to select the best system out of the many CAD systems in existence. During the initial stage of the evaluation project, researchers…

  18. Acquired Immune Deficiency Syndrome, AIDS: A Selected Bibliography of Federal Government Publications. Research Guide 90 104.

    ERIC Educational Resources Information Center

    Alexander, Margaret

    This research guide presents a selected bibliography of federal government publications about the Acquired Immune Deficiency Syndrome (AIDS). These documents are listed in five categories: (1) Bibliographies (7); (2) Congressional Publications (69 hearings and reports); (3) Executive Branch Publications (43 reports); (4) Federal Government…

  19. Community Colleges Tackle Student Health and HIV/AIDS. AACC Research Brief.

    ERIC Educational Resources Information Center

    Ottenritter, Nan; Barnett, Lynn

    This research brief summarizes the findings of a survey conducted in 1996 to determine the involvement of community colleges in the health of their students. The survey gathered information from 535 campuses concerning administration and leadership, curriculum, and community relationships. This report focuses on HIV/AIDS and the extent to which…

  20. Job Performance Aids: Research and Technology State-of-the-Art. Final Report.

    ERIC Educational Resources Information Center

    Booher, Harold R.

    Conducted as part of a major effort to test and evaluate Job Performance Aids (JPA) and their integration with Navy personnel and training systems, this study systematically reviewed and organized existing JPA techniques, related research data, and various applicable principles and concepts. One hundred and one JPA systems and techniques were…

  1. Water management: Current and future challenges and research directions

    NASA Astrophysics Data System (ADS)

    Cosgrove, William J.; Loucks, Daniel P.

    2015-06-01

    Water distinguishes our planet compared to all the others we know about. While the global supply of available freshwater is more than adequate to meet all current and foreseeable water demands, its spatial and temporal distributions are not. There are many regions where our freshwater resources are inadequate to meet domestic, economic development and environmental needs. In such regions, the lack of adequate clean water to meet human drinking water and sanitation needs is indeed a constraint on human health and productivity and hence on economic development as well as on the maintenance of a clean environment and healthy ecosystems. All of us involved in research must find ways to remove these constraints. We face multiple challenges in doing that, especially given a changing and uncertain future climate, and a rapidly growing population that is driving increased social and economic development, globalization, and urbanization. How best to meet these challenges requires research in all aspects of water management. Since 1965, the journal Water Resources Research has played an important role in reporting and disseminating current research related to managing the quantity and quality and cost of this resource. This paper identifies the issues facing water managers today and future research needed to better inform those who strive to create a more sustainable and desirable future.

  2. A future perspective on technological obsolescenceat NASA, Langley Research Center

    NASA Technical Reports Server (NTRS)

    Mcintyre, Robert M.

    1990-01-01

    The present research effort was the first phase of a study to forecast whether technological obsolescence will be a problem for the engineers, scientists, and technicians at NASA Langley Research Center (LaRC). There were four goals of the research: to review the literature on technological obsolescence; to determine through interviews of division chiefs and branch heads Langley's perspective on future technological obsolescence; to begin making contacts with outside industries to find out how they view the possibility of technological obsolescence; and to make preliminary recommendations for dealing with the problem. A complete description of the findings of this research can be reviewed in a technical report in preparation. The following are a small subset of the key findings of the study: NASA's centers and divisions vary in their missions and because of this, in their capability to control obsolescence; research-oriented organizations within NASA are believed by respondents to keep up to date more than the project-oriented organizations; asked what are the signs of a professional's technological obsolescence, respondents had a variety of responses; top performing scientists were viewed as continuous learners, keeping up to date by a variety of means; when asked what incentives were available to aerospace technologists for keeping up to data, respondents specified a number of ideas; respondents identified many obstacles to professionals' keeping up to date in the future; and most respondents expressed some concern for the future of the professionals at NASA vis a vis the issue of professional obsolescence.

  3. Understanding Faculty Perceptions of the Future: Action Research for Academic Librarians

    ERIC Educational Resources Information Center

    Malenfant, Kara Josephine

    2011-01-01

    The intent of this study was to aid academic librarians in examining their perceptions of the future of higher education, engaging disciplinary faculty members to understand their views, and determining actions to take to shape the future. In this mixed methods study, scenarios about the future of higher education served as the basis for…

  4. Space robotics: Recent accomplishments and opportunities for future research

    NASA Technical Reports Server (NTRS)

    Montgomery, Raymond C.; Buttrill, Carey S.; Dorsey, John T.; Juang, Jer-Nan; Lallman, Frederick J.; Moerder, Daniel D.; Scott, Michael A.; Troutman, Patrick; Williams, Robert L., II

    1992-01-01

    The Langley Guidance, Navigation, and Control Technical Committee (GNCTC) was one of six technical committees created in 1991 by the Chief Scientist, Dr. Michael F. Card. During the kickoff meeting Dr. Card charged the chairmen to: (1) establish a cross-Center committee; (2) support at least one workshop in a selected discipline; and (3) prepare a technical paper on recent accomplishments in the discipline and on opportunities for future research. The Guidance, Navigation, and Control Committee was formed and selected for focus on the discipline of Space robotics. This report is a summary of the committee's assessment of recent accomplishments and opportunities for future research. The report is organized as follows. First is an overview of the data sources used by the committee. Next is a description of technical needs identified by the committee followed by recent accomplishments. Opportunities for future research ends the main body of the report. It includes the primary recommendation of the committee that NASA establish a national space facility for the development of space automation and robotics, one element of which is a telerobotic research platform in space. References 1 and 2 are the proceedings of two workshops sponsored by the committee during its June 1991, through May 1992 term. The focus of the committee for the June 1992 - May 1993 term will be to further define to the recommended platform in space and to add an additional discipline which includes aircraft related GN&C issues. To the latter end members performing aircraft related research will be added to the committee. (A preliminary assessment of future opportunities in aircraft-related GN&C research has been included as appendix A.)

  5. Minorities Remain Underrepresented in HIV/AIDS Research Despite Access to Clinical Trials

    PubMed Central

    Castillo-Mancilla, Jose R.; Cohn, Susan E.; Krishnan, Supriya; Cespedes, Michelle; Floris-Moore, Michelle; Schulte, Gail; Pavlov, Gregory; Mildvan, Donna; Smith, Kimberly Y.

    2014-01-01

    Background The reasons for minority underrepresentation in HIV/AIDS clinical trials remain unclear. We aimed to evaluate the knowledge, experience and factors that influence minority participation in HIV/AIDS studies in the US. Methods An anonymous, bilingual, self-administered survey on study participation was given to HIV-infected adults attending AIDS Clinical Trials Group-affiliated clinics in the US and Puerto Rico. Chi-square tests were used to evaluate differences by race/first language/level of education. Logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for factors associated with being talked to about participation in a study. Results We analyzed 2,175 complete surveys (221 in Spanish). Among respondents, 31% were White, 40% black/African American (AA) and 21% Hispanic. The overall rate of previous participation in any HIV/AIDS study was 48%. Hispanics were less likely to know about studies compared to whites and AAs (67% vs. 74% and 76%; p<0.001). Compared to whites, AAs and Hispanics were less likely to have been talked to about participating in a study (76% vs. 67% and 67%; p<0.001). The OR for being talked to about participating in a study was 0.65 (95% CI: 0.52–0.81) for AAs and 0.65 (95% CI: 0.49–0.85) for Hispanics, compared to whites. AAs and Hispanics were more likely to state that studies were not friendly to their race (17% and 10% vs. 4%; p<0.001). Conclusions Minorities continue to face barriers for HIV/AIDS trial participation, even when clinical research is available. Enrollment strategies should better target minorities to improve recruitment in HIV/AIDS research. PMID:24518211

  6. Delivering patient decision aids on the Internet: definitions, theories, current evidence, and emerging research areas

    PubMed Central

    2013-01-01

    Background In 2005, the International Patient Decision Aids Standards Collaboration identified twelve quality dimensions to guide assessment of patient decision aids. One dimension—the delivery of patient decision aids on the Internet—is relevant when the Internet is used to provide some or all components of a patient decision aid. Building on the original background chapter, this paper provides an updated definition for this dimension, outlines a theoretical rationale, describes current evidence, and discusses emerging research areas. Methods An international, multidisciplinary panel of authors examined the relevant theoretical literature and empirical evidence through 2012. Results The updated definition distinguishes Internet-delivery of patient decision aids from online health information and clinical practice guidelines. Theories in cognitive psychology, decision psychology, communication, and education support the value of Internet features for providing interactive information and deliberative support. Dissemination and implementation theories support Internet-delivery for providing the right information (rapidly updated), to the right person (tailored), at the right time (the appropriate point in the decision making process). Additional efforts are needed to integrate the theoretical rationale and empirical evidence from health technology perspectives, such as consumer health informatics, user experience design, and human-computer interaction. Despite Internet usage ranging from 74% to 85% in developed countries and 80% of users searching for health information, it is unknown how many individuals specifically seek patient decision aids on the Internet. Among the 86 randomized controlled trials in the 2011 Cochrane Collaboration’s review of patient decision aids, only four studies focused on Internet-delivery. Given the limited number of published studies, this paper particularly focused on identifying gaps in the empirical evidence base and

  7. Future Requirements for Satellite Altimetry: Recommendations from the GAMBLE Project for Future Missions and Research Programmes

    NASA Astrophysics Data System (ADS)

    Cotton, P. D.; Menard, Y.

    2006-07-01

    The GAMBLE th ematic network brought together European exper ts in ocean altimetry to consider future developmen ts in satellite altimetry. The aim was to provide r ecommendations for research activ ities, and future altimeter missions, th at w ere necessary to support and build on present developments in operational o ceanography and to main tain o cean monitoring programmes. This paper reviews user r equiremen ts for operational products th at rely on altimeter d ata, and assess how well presen t and planned activities satisfy those requ irements. It provides recommendations for future missions required to form a cost-eff ectiv e, robust, operational satellite altimeter measuremen t system. [1] provides a full discussion.

  8. Back to a Future: One Man's AIDS Tale Shows How Quickly Epidemic Has Turned.

    PubMed

    Sanford

    1997-01-01

    WHEN IT WAS CALLED 'GRID': One year ago today, I told my colleagues that I was dying of AIDS. I had been fighting it for years-the illness and the telling. I had been taking AZT, and briefly even a drug given to lepers. But now I was gaunt, tired and rather sure I was losing the battle. I gave my boss an obituary I had written-I'm a features editor on Page One of The Wall Street Journal, so I certainly didn't want anybody else writing it-sent a note to my boss's boss and started saying my goodbyes. Last week, my doctor, Jerome E. Groopman, noticed that I am getting fat and said it wouldn't be a bad idea if I went on a modest diet. At age 53, I am going to the gym again. I need to buy some new clothes. I am planning to one day retire with my partner of 28 years, who is HIV-negative. What has happened in the past year, at least for me, is a miracle that couldn't have taken place at any other moment. The year 1996 is when everything changed, and very quickly, for people with AIDS. I have been grappling with this disease for nearly a decade and a half, almost since the beginning, when it was called Gay Related Immune Deficiency, or GRID. I've outlived friends and peers, and now I find myself in the unusual position of telling people how I've survived this scourge, something I never thought would happen. My condition could change for the worse tomorrow. But today I feel well again. Thanks to the arrival of the new drugs called protease inhibitors, I am probably more likely to be hit by a truck than to die of AIDS. In coming alive again, I've learned the value of a good doctor and good friends-and the importance of being honest with yourself, your co-workers and the people you love. My battle with AIDS, I'm certain, began in December 1982, at a bathhouse in Manhattan's East Village during a sexual encounter with a man whose name I didn't catch. Like other gay men, I had kept up with newspaper reports, beginning with a July 3, 1981, New York Times story with the fateful

  9. Working Memory and Hearing Aid Processing: Literature Findings, Future Directions, and Clinical Applications.

    PubMed

    Souza, Pamela; Arehart, Kathryn; Neher, Tobias

    2015-01-01

    Working memory-the ability to process and store information-has been identified as an important aspect of speech perception in difficult listening environments. Working memory can be envisioned as a limited-capacity system which is engaged when an input signal cannot be readily matched to a stored representation or template. This "mismatch" is expected to occur more frequently when the signal is degraded. Because working memory capacity varies among individuals, those with smaller capacity are expected to demonstrate poorer speech understanding when speech is degraded, such as in background noise. However, it is less clear whether (and how) working memory should influence practical decisions, such as hearing treatment. Here, we consider the relationship between working memory capacity and response to specific hearing aid processing strategies. Three types of signal processing are considered, each of which will alter the acoustic signal: fast-acting wide-dynamic range compression, which smooths the amplitude envelope of the input signal; digital noise reduction, which may inadvertently remove speech signal components as it suppresses noise; and frequency compression, which alters the relationship between spectral peaks. For fast-acting wide-dynamic range compression, a growing body of data suggests that individuals with smaller working memory capacity may be more susceptible to such signal alterations, and may receive greater amplification benefit with "low alteration" processing. While the evidence for a relationship between wide-dynamic range compression and working memory appears robust, the effects of working memory on perceptual response to other forms of hearing aid signal processing are less clear cut. We conclude our review with a discussion of the opportunities (and challenges) in translating information on individual working memory into clinical treatment, including clinically feasible measures of working memory. PMID:26733899

  10. Working Memory and Hearing Aid Processing: Literature Findings, Future Directions, and Clinical Applications

    PubMed Central

    Souza, Pamela; Arehart, Kathryn; Neher, Tobias

    2015-01-01

    Working memory—the ability to process and store information—has been identified as an important aspect of speech perception in difficult listening environments. Working memory can be envisioned as a limited-capacity system which is engaged when an input signal cannot be readily matched to a stored representation or template. This “mismatch” is expected to occur more frequently when the signal is degraded. Because working memory capacity varies among individuals, those with smaller capacity are expected to demonstrate poorer speech understanding when speech is degraded, such as in background noise. However, it is less clear whether (and how) working memory should influence practical decisions, such as hearing treatment. Here, we consider the relationship between working memory capacity and response to specific hearing aid processing strategies. Three types of signal processing are considered, each of which will alter the acoustic signal: fast-acting wide-dynamic range compression, which smooths the amplitude envelope of the input signal; digital noise reduction, which may inadvertently remove speech signal components as it suppresses noise; and frequency compression, which alters the relationship between spectral peaks. For fast-acting wide-dynamic range compression, a growing body of data suggests that individuals with smaller working memory capacity may be more susceptible to such signal alterations, and may receive greater amplification benefit with “low alteration” processing. While the evidence for a relationship between wide-dynamic range compression and working memory appears robust, the effects of working memory on perceptual response to other forms of hearing aid signal processing are less clear cut. We conclude our review with a discussion of the opportunities (and challenges) in translating information on individual working memory into clinical treatment, including clinically feasible measures of working memory. PMID:26733899

  11. Collaborative AIDS prevention research in the developing world: the CAPS experience.

    PubMed

    Hearst, N; Mandel, J S; Coates, T J

    1995-07-01

    Prevention through behavior change is the only way to control the spread of HIV infection in the developing world. Success in prevention requires consistent and persistent intervention over time, a clear understanding of the realities of target populations, and involvement of members of these populations in prevention efforts. Applied local research is urgently needed, especially in the developing world, to design interventions that meet these criteria and to test their effectiveness. The Center for AIDS Prevention Studies (CAPS) model of international collaborative research has been used at the University of California, San Francisco, for the past eight years. The model involves an intensive period for protocol development and another one for data analysis. Each year, 8-10 scientists from developing countries visit CAPS in San Francisco for 10 weeks of intensive learning and collaboration. They are immersed in HIV epidemiology, research design, computer skills, data management, and psychosocial aspect of the AIDS epidemic. The main emphasis is on designing a protocol for a research project related to AIDS prevention in the visiting scientist's home country. The greatest impediment to intervention trials in developing countries is lack of funding. CAPS provides pilot study funding and technical assistance to implement the project in the home country. In the summer of 1995 eight alumni worked intensively with the CAPS faculty on data analysis and manuscript preparation. The quality of the resulting collaborative research is represented by the articles published and by the many alumni of the program who have undertaken additional research projects and/or assumed leadership positions in AIDS control efforts in their countries. These studies cover a wide range of risk groups, including sexually transmitted disease patients in Zambia; adolescents in the Philippines and Russia; wives of HIV-infected men in Uganda; female sex workers in Brazil, India, and Thailand; and

  12. Shaping the Future of Research: a perspective from junior scientists

    PubMed Central

    MacKellar, Drew C.; Mazzilli, Sarah A.; Pai, Vaibhav P.; Goodwin, Patricia R.; Walsh, Erica M.; Robinson-Mosher, Avi; Bowman, Thomas A.; Kraemer, James; Erb, Marcella L.; Schoenfeld, Eldi; Shokri, Leila; Jackson, Jonathan D.; Islam, Ayesha; Mattozzi, Matthew D.; Krukenberg, Kristin A.; Polka, Jessica K.

    2015-01-01

    The landscape of scientific research and funding is in flux as a result of tight budgets, evolving models of both publishing and evaluation, and questions about training and workforce stability. As future leaders, junior scientists are uniquely poised to shape the culture and practice of science in response to these challenges. A group of postdocs in the Boston area who are invested in improving the scientific endeavor, planned a symposium held on October 2 nd and 3 rd, 2014, as a way to join the discussion about the future of US biomedical research. Here we present a report of the proceedings of participant-driven workshops and the organizers’ synthesis of the outcomes. PMID:25653845

  13. Drug discovery research in India: current state and future prospects.

    PubMed

    Balganesh, Tanjore; Kundu, Tapas K; Chakraborty, Tushar Kanti; Roy, Siddhartha

    2014-07-10

    Indian civilization developed a strong system of traditional medicine and was one of the first nations to develop a synthetic drug. In the postindependence era, Indian pharmaceutical industry developed a strong base for production of generic drugs. Challenges for the future are to give its traditional medicine a strong scientific base and develop research and clinical capability to consistently produce new drugs based on advances in modern biological sciences. PMID:25050153

  14. Advances and future directions of research on spectral methods

    NASA Technical Reports Server (NTRS)

    Patera, A. T.

    1986-01-01

    Recent advances in spectral methods are briefly reviewed and characterized with respect to their convergence and computational complexity. Classical finite element and spectral approaches are then compared, and spectral element (or p-type finite element) approximations are introduced. The method is applied to the full Navier-Stokes equations, and examples are given of the application of the technique to several transitional flows. Future directions of research in the field are outlined.

  15. The microball and Gammasphere: Research highlights and future directions

    SciTech Connect

    Devlin, M.; Sarantites, D.G.; LaFosse, D.R.; Lerma, F.

    1996-12-31

    The Microball, a compact, 4{pi} charged-particle detector array, has been used in conjunction with Gammasphere for numerous physics experiments, and more are planned in the near future. A summary of this research program is presented, and the device and its capabilities are described. An example of its use in the study of the population and entry state excitation energy distributions of normal and superdeformed bands in {sup 82}Sr is presented.

  16. FIFE in 1992 - Results, scientific gains, and future research directions

    NASA Technical Reports Server (NTRS)

    Sellers, P. J.; Hall, F. G.

    1992-01-01

    A summary is presented of some of the more significant findings of the science teams and science staff of FIFE, emphasizing scientific gains, and outlining some future research directions. Attention is given to interactions between surface and boudary layer heat fluxes, momentum fluxes, and correlations between near-surface heat and CO2 fluxes and satellite data. Consideration is given to improved understanding of the exchanges between the land surface and the atmosphere at the local scale.

  17. Future directions in air quality research: economic issues.

    PubMed

    Adams, Richard M; Horst, Robert L

    2003-06-01

    Our challenge was to address future directions in air quality research that involve economic issues. The paper outlines the role of economics in the evaluation of air pollution impacts on environmental systems and describes existing research. We identify studies that address economic effects in the agricultural sector, in the commercial forest sector, and in unmanaged natural systems. Effects related to ozone exposure are highlighted. The summary of available research is followed by a discussion of research recommendations. Several short-term recommendations are identified that can augment some of the new research being considered by scientists. A more ambitious, long-term research project is outlined for valuing air pollution impacts in unmanaged natural environments. Specifically, the paper describes possible advantages of an 'integrated assessment' framework that more formally brings together the complex relationships that exist in both ecological and economic systems. A final section contains thoughts on the importance of education (i.e., information transfer) in the research process, especially in relation to policy. It is further noted that education should be inclusive of all members of the research team, throughout all stages of the research process. PMID:12676216

  18. Food reward system: current perspectives and future research needs

    PubMed Central

    Woods, Stephen C.; Pelchat, Marcia; Grigson, Patricia Sue; Stice, Eric; Farooqi, Sadaf; Khoo, Chor San; Mattes, Richard D.; Beauchamp, Gary K.

    2015-01-01

    This article reviews current research and cross-disciplinary perspectives on the neuroscience of food reward in animals and humans, examines the scientific hypothesis of food addiction, discusses methodological and terminology challenges, and identifies knowledge gaps and future research needs. Topics addressed herein include the role of reward and hedonic aspects in the regulation of food intake, neuroanatomy and neurobiology of the reward system in animals and humans, responsivity of the brain reward system to palatable foods and drugs, translation of craving versus addiction, and cognitive control of food reward. The content is based on a workshop held in 2013 by the North American Branch of the International Life Sciences Institute. PMID:26011903

  19. Substorms - Future of magnetospheric substorm-storm research

    SciTech Connect

    Akasofu, S.I. )

    1989-04-01

    Seven approaches and/or areas of magnetospheric substorm and storm science which should be emphasized in future research are briefly discussed. They are: the combining of groups of researchers who study magnetic storms and substorms in terms of magnetic reconnection with those that do not, the possible use of a magnetosphere-ionosphere coupling model to merge the groups, the development of improved input-output relationships, the complementing of satellite and ground-based observations, the need for global imaging of the magnetosphere, the complementing of observations with computer simulations, and the need to study the causes of changes in the north-south component of the IMF. 36 refs.

  20. Status of Problem-Based Learning Research in Pharmacy Education: A Call for Future Research.

    ERIC Educational Resources Information Center

    Cisneros, Robert M.; Salisbury-Glennon, Jill D.; Anderson-Harper, Heidi M.

    2002-01-01

    Reviews the current status of problem-based learning (PBL) research in pharmacy education, identifies trends and student outcomes from the pharmacy courses that have used PBL, presents a brief review of PBL research in medical education, and recommends future directions for PBL research in pharmacy education. (EV)

  1. Personalized Telehealth in the Future: A Global Research Agenda.

    PubMed

    Dinesen, Birthe; Nonnecke, Brandie; Lindeman, David; Toft, Egon; Kidholm, Kristian; Jethwani, Kamal; Young, Heather M; Spindler, Helle; Oestergaard, Claus Ugilt; Southard, Jeffrey A; Gutierrez, Mario; Anderson, Nick; Albert, Nancy M; Han, Jay J; Nesbitt, Thomas

    2016-01-01

    As telehealth plays an even greater role in global health care delivery, it will be increasingly important to develop a strong evidence base of successful, innovative telehealth solutions that can lead to scalable and sustainable telehealth programs. This paper has two aims: (1) to describe the challenges of promoting telehealth implementation to advance adoption and (2) to present a global research agenda for personalized telehealth within chronic disease management. Using evidence from the United States and the European Union, this paper provides a global overview of the current state of telehealth services and benefits, presents fundamental principles that must be addressed to advance the status quo, and provides a framework for current and future research initiatives within telehealth for personalized care, treatment, and prevention. A broad, multinational research agenda can provide a uniform framework for identifying and rapidly replicating best practices, while concurrently fostering global collaboration in the development and rigorous testing of new and emerging telehealth technologies. In this paper, the members of the Transatlantic Telehealth Research Network offer a 12-point research agenda for future telehealth applications within chronic disease management. PMID:26932229

  2. Personalized Telehealth in the Future: A Global Research Agenda

    PubMed Central

    2016-01-01

    As telehealth plays an even greater role in global health care delivery, it will be increasingly important to develop a strong evidence base of successful, innovative telehealth solutions that can lead to scalable and sustainable telehealth programs. This paper has two aims: (1) to describe the challenges of promoting telehealth implementation to advance adoption and (2) to present a global research agenda for personalized telehealth within chronic disease management. Using evidence from the United States and the European Union, this paper provides a global overview of the current state of telehealth services and benefits, presents fundamental principles that must be addressed to advance the status quo, and provides a framework for current and future research initiatives within telehealth for personalized care, treatment, and prevention. A broad, multinational research agenda can provide a uniform framework for identifying and rapidly replicating best practices, while concurrently fostering global collaboration in the development and rigorous testing of new and emerging telehealth technologies. In this paper, the members of the Transatlantic Telehealth Research Network offer a 12-point research agenda for future telehealth applications within chronic disease management. PMID:26932229

  3. Planning for the future workforce in hematology research.

    PubMed

    Hoots, W Keith; Abkowitz, Janis L; Coller, Barry S; DiMichele, Donna M

    2015-04-30

    The medical research and training enterprise in the United States is complex in both its scope and implementation. Accordingly, adaptations to the associated workforce needs present particular challenges. This is particularly true for maintaining or expanding national needs for physician-scientists where training resource requirements and competitive transitional milestones are substantial. For the individual, these phenomena can produce financial burden, prolong the career trajectory, and significantly influence career pathways. Hence, when national data suggest that future medical research needs in a scientific area may be met in a less than optimal manner, strategies to expand research and training capacity must follow. This article defines such an exigency for research and training in nonneoplastic hematology and presents potential strategies for addressing these critical workforce needs. The considerations presented herein reflect a summary of the discussions presented at 2 workshops cosponsored by the National Heart, Lung, and Blood Institute and the American Society of Hematology. PMID:25758827

  4. Future Research and Policy Directions in Physician Reimbursement

    PubMed Central

    McMenamin, Peter

    1981-01-01

    Payments to physicians absorb the second largest share of the health care dollar in the United States. In 1979, the share was 19 percent of the total, or $40.6 billion (Gibson, 1980). The Health Care Financing Administration (HCFA) alone spent $8.6 billion for physician services, representing approximately 16 percent of all public funds disbursed under HCFA programs. This paper presents an overview of various issues concerning physician reimbursement. Several major areas have been identified (access, cost, quality, and improving or refining the Office of Research, Demonstrations, and Statistics' [ORDS] research techniques for analyzing topics concerning physician reimbursement). Each area is introduced with a brief discussion of some of the problems associated with the physician reimbursement systems relating to that area. Selected results are then presented from the previous research in each area, along with descriptions of continuing studies currently underway. Each section concludes with a discussion of potential future directions for new research or data development. PMID:10309465

  5. Genome research in Austria--a program of the future.

    PubMed

    Pasterk, Markus G

    2002-11-01

    Genome research is a central area both for progress in scientific findings in life sciences and for the innovative capacity in medical science, and the pharmaceutical and biotech industries. The research findings obtained by interdisciplinary cooperation are of paramount epistemological importance. They will establish a new understanding of biology. In this context, there will be revolutionary opportunities for new medical therapies, for instance, or for keeping plants and animals healthy. Austria will participate in this science and innovation field and will use the resulting opportunities for scientific and economic development as well as for overall social prosperity. For this purpose, [corrected] Austria has developed the 'Austrian Genome Research Programme', a 'programme of the future' for Austria. This program will be based on the good foundations that genome research has already established in Austria. PMID:12437484

  6. Planning for the future workforce in hematology research

    PubMed Central

    Abkowitz, Janis L.; Coller, Barry S.; DiMichele, Donna M.

    2015-01-01

    The medical research and training enterprise in the United States is complex in both its scope and implementation. Accordingly, adaptations to the associated workforce needs present particular challenges. This is particularly true for maintaining or expanding national needs for physician-scientists where training resource requirements and competitive transitional milestones are substantial. For the individual, these phenomena can produce financial burden, prolong the career trajectory, and significantly influence career pathways. Hence, when national data suggest that future medical research needs in a scientific area may be met in a less than optimal manner, strategies to expand research and training capacity must follow. This article defines such an exigency for research and training in nonneoplastic hematology and presents potential strategies for addressing these critical workforce needs. The considerations presented herein reflect a summary of the discussions presented at 2 workshops cosponsored by the National Heart, Lung, and Blood Institute and the American Society of Hematology. PMID:25758827

  7. Relationship Education Research: Current Status and Future Directions

    PubMed Central

    Markman, Howard J.; Rhoades, Galena K.

    2011-01-01

    The overarching aim of this paper is to review research on relationship education programs and approaches that have been published or accepted for publication since the last review article in 2002. This paper provides a critical overview of the relationship education field and sets an agenda for research and practice for the next decade. A theme weaved throughout the paper are the ways in which relationship education is similar and different from couples therapy and we conclude that there can be a synergistic, healthy marriage between the two. We then provide recommendations for future directions for research in the relationship education field. Finally, the co-authors comment on our experiences in both the relationship education field and couples therapy field as both researchers and interventionists. PMID:22283386

  8. Affordances of Augmented Reality in Science Learning: Suggestions for Future Research

    NASA Astrophysics Data System (ADS)

    Cheng, Kun-Hung; Tsai, Chin-Chung

    2013-08-01

    Augmented reality (AR) is currently considered as having potential for pedagogical applications. However, in science education, research regarding AR-aided learning is in its infancy. To understand how AR could help science learning, this review paper firstly has identified two major approaches of utilizing AR technology in science education, which are named as image- based AR and location- based AR. These approaches may result in different affordances for science learning. It is then found that students' spatial ability, practical skills, and conceptual understanding are often afforded by image-based AR and location-based AR usually supports inquiry-based scientific activities. After examining what has been done in science learning with AR supports, several suggestions for future research are proposed. For example, more research is required to explore learning experience (e.g., motivation or cognitive load) and learner characteristics (e.g., spatial ability or perceived presence) involved in AR. Mixed methods of investigating learning process (e.g., a content analysis and a sequential analysis) and in-depth examination of user experience beyond usability (e.g., affective variables of esthetic pleasure or emotional fulfillment) should be considered. Combining image-based and location-based AR technology may bring new possibility for supporting science learning. Theories including mental models, spatial cognition, situated cognition, and social constructivist learning are suggested for the profitable uses of future AR research in science education.

  9. Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation

    PubMed Central

    Warnich, Louise; Drögemöller, Britt I; Pepper, Michael S; Dandara, Collet; Wright, Galen E.B

    2011-01-01

    South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This includes both communicable (e.g., HIV/AIDS and tuberculosis) and non-communicable (e.g., diabetes and cardiovascular) diseases. For example, although only 0.7% of the world’s population lives in South Africa, the country carries 17% of the global HIV/AIDS burden and 5% of the global tuberculosis burden. Nobel Peace Prize Laureate Archbishop Emeritus Desmond Tutu has coined the term Rainbow Nation, referring to a land of wealth in its many diverse peoples and cultures. It is now timely and necessary to reflect on how best to approach new genomics biotechnologies in a manner that carefully considers the public health needs and extant disease burden in the region. The aim of this paper is to document and review the advances in pharmacogenomics in South Africa and importantly, to evaluate the direction that future research should take. Previous research has shown that the populations in South Africa exhibit unique allele frequencies and novel genetic variation in pharmacogenetically relevant genes, often differing from other African and global populations. The high level of genetic diversity, low linkage disequilibrium and the presence of rare variants in these populations question the feasibility of the use of current commercially available genotyping platforms, and may partially account for genotype-phenotype discordance observed in past studies. However, the employment of high throughput technologies for genomic research, within the context of large clinical trials, combined with interdisciplinary studies and appropriate regulatory guidelines, should aid in acceleration of pharmacogenomic discoveries in high priority therapeutic areas in South Africa. Finally, we suggest that projects such as the H3Africa Initiative, the SAHGP and PGENI should play an integral role

  10. Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation.

    PubMed

    Warnich, Louise; Drögemöller, Britt I; Pepper, Michael S; Dandara, Collet; Wright, Galen E B

    2011-09-01

    South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This includes both communicable (e.g., HIV/AIDS and tuberculosis) and non-communicable (e.g., diabetes and cardiovascular) diseases. For example, although only 0.7% of the world's population lives in South Africa, the country carries 17% of the global HIV/AIDS burden and 5% of the global tuberculosis burden. Nobel Peace Prize Laureate Archbishop Emeritus Desmond Tutu has coined the term Rainbow Nation, referring to a land of wealth in its many diverse peoples and cultures. It is now timely and necessary to reflect on how best to approach new genomics biotechnologies in a manner that carefully considers the public health needs and extant disease burden in the region. The aim of this paper is to document and review the advances in pharmacogenomics in South Africa and importantly, to evaluate the direction that future research should take. Previous research has shown that the populations in South Africa exhibit unique allele frequencies and novel genetic variation in pharmacogenetically relevant genes, often differing from other African and global populations. The high level of genetic diversity, low linkage disequilibrium and the presence of rare variants in these populations question the feasibility of the use of current commercially available genotyping platforms, and may partially account for genotype-phenotype discordance observed in past studies. However, the employment of high throughput technologies for genomic research, within the context of large clinical trials, combined with interdisciplinary studies and appropriate regulatory guidelines, should aid in acceleration of pharmacogenomic discoveries in high priority therapeutic areas in South Africa. Finally, we suggest that projects such as the H3Africa Initiative, the SAHGP and PGENI should play an integral role

  11. Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research.

    PubMed

    Siskind, Rona L; Andrasik, Michele; Karuna, Shelly T; Broder, Gail B; Collins, Clare; Liu, Albert; Lucas, Jonathan Paul; Harper, Gary W; Renzullo, Philip O

    2016-08-15

    In 2009, the National Institutes of Health recognized the need to expand knowledge of lesbian, gay, bisexual, and transgender (LGBT) health and commissioned the Institute of Medicine to report on the health of these populations in the United States. The resulting Institute of Medicine publication called for more knowledge of the health of LGBT populations, as well as improved methodologies to reach them, more LGBT-focused research, and enhanced training programs and cultural competency of physicians and researchers. Several of the National Institutes of Health-funded HIV/AIDS clinical trials networks, including the Adolescent Medicine Trials Network for HIV/AIDS Interventions, HIV Prevention Trials Network, HIV Vaccine Trials Network, and Microbicide Trials Network, have focused attention on engaging transgender (TG) individuals in research. They have identified issues that transcend the nature of research (ie, treatment or prevention, adult or adolescent) and have adopted various approaches to effectively engage the TG community. Each network has recognized the importance of developing partnerships to build trust with and seek input from TG individuals on research plans and policies. They have established standing advisory groups and convened consultations for this purpose. To ensure that trial data are reflective of the participants they are seeking to enroll, they have reviewed and revised data collection forms to incorporate the 2-step method of collecting sex at birth and gender identity as 2 independent variables, and some have also revised research protocol templates and policies for concept development to ensure that they are appropriate for the inclusion of TG participants. The networks have also initiated trainings to enhance cultural sensitivity and developed a range of materials and resources for network and clinical research site staff. They continue to identify TG-specific research needs in an effort to be more responsive to and improve the health of

  12. Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research

    PubMed Central

    Andrasik, Michele; Karuna, Shelly T.; Broder, Gail B.; Collins, Clare; Liu, Albert; Lucas, Jonathan Paul; Harper, Gary W.; Renzullo, Philip O.

    2016-01-01

    Abstract: In 2009, the National Institutes of Health recognized the need to expand knowledge of lesbian, gay, bisexual, and transgender (LGBT) health and commissioned the Institute of Medicine to report on the health of these populations in the United States. The resulting Institute of Medicine publication called for more knowledge of the health of LGBT populations, as well as improved methodologies to reach them, more LGBT-focused research, and enhanced training programs and cultural competency of physicians and researchers. Several of the National Institutes of Health–funded HIV/AIDS clinical trials networks, including the Adolescent Medicine Trials Network for HIV/AIDS Interventions, HIV Prevention Trials Network, HIV Vaccine Trials Network, and Microbicide Trials Network, have focused attention on engaging transgender (TG) individuals in research. They have identified issues that transcend the nature of research (ie, treatment or prevention, adult or adolescent) and have adopted various approaches to effectively engage the TG community. Each network has recognized the importance of developing partnerships to build trust with and seek input from TG individuals on research plans and policies. They have established standing advisory groups and convened consultations for this purpose. To ensure that trial data are reflective of the participants they are seeking to enroll, they have reviewed and revised data collection forms to incorporate the 2-step method of collecting sex at birth and gender identity as 2 independent variables, and some have also revised research protocol templates and policies for concept development to ensure that they are appropriate for the inclusion of TG participants. The networks have also initiated trainings to enhance cultural sensitivity and developed a range of materials and resources for network and clinical research site staff. They continue to identify TG-specific research needs in an effort to be more responsive to and improve

  13. Some ideas on the emerging future of developmental research.

    PubMed

    Kloep, Marion; Hendry, Leo B

    2014-12-01

    We are somewhat critical of the concept of emerging adulthood as a new developmental stage in modern industrial societies, and prefer the idea of systemic mechanisms and processes as the forces and factors that influence the transitions and transformations of human change across the life course. For this reason, we are pleased to see this volume is entirely dedicated to the life-phase of emerging adulthood in Mediterranean countries, suggesting that researchers are not convinced that the characteristics of emerging adulthood would be the same for young people from different cultures. While we are very positive towards this series of articles showing that emerging adulthood in Mediterranean countries has similarities, and, yet differences to other cultures, and appreciate the diverse findings of these research projects, we would want to suggest some new and more radical strategies for future developmental research. Concretely, a move away from age-bound, stage models towards a more dynamic and systemic approach to lifespan research, simply because we cannot ignore both the past and the future, whilst contemplating the present. PMID:25266579

  14. Future directions of C3 research at DARPA (Defense Advanced Research Projects Agency)

    NASA Astrophysics Data System (ADS)

    Perry, D. G.; Dahmann, J. S.

    Research into C3 related problems is a major effort of the Information Science and Technology Office of the Defense Advanced Research Projects Agency. The major thrusts of projects are in the area of future, high-risk efforts, often resulting in the development of a conceptual model or prototype. Some of these prototypes are then further developed to provide an infrastructure for future research. The programs can be divided into two groups: base technology research programs and testbed programs. The testbeds provide a focus for the technology programs.

  15. Future directions of C3 research at DARPA (Defense Advanced Research Projects Agency)

    SciTech Connect

    Perry, D.G.; Dahmann, J.S.

    1987-01-01

    Research into C3 related problems is a major effort of the Information Science and Technology Office of the Defense Advanced Research Projects Agency. The major thrusts of projects is in the area of future, high-risk efforts, often resulting in the development of a conceptual model or prototype. Some of these prototypes are then further developed to provide an infrastructure for future research. The programs can be divided into two groups: base technology research programs and testbed programs. The testbeds provide a focus for the technology programs.

  16. Trends in catalysis research to meet future refining needs

    SciTech Connect

    Absi-Halabi, M.; Stanislaus, A.; Qabazard, H.

    1997-02-01

    The main emphasis of petroleum refining during the `70s and early `80s was to maximize conversion of heavy oils to gasoline and middle distillate products. While this objective is still important, the current focus that began in the late `80s is to develop cleaner products. This is a result of strict environmental constraints to reduce emissions from both the products and refineries. Developing catalysts with improved activity, selectivity and stability for use in processes producing such environmentally acceptable fuels is the most economical and effective route for refiners. Novel technologies such as biocatalysis and catalytic membranes are examples of current successful laboratory-scale attempts to resolve anticipated future industry problems. Since catalysts play a key role in refining processes, it is important to examine the challenges facing catalysis research to meet future refining developments. The paper discusses the factors influencing refining, advancements in refining technology and catalysis, short-term future trends in refining catalysts research, and long-term trends in refining catalysts. 56 refs.

  17. Women, Reproductive Rights, and HIV/AIDS: Issues on Which Research and Interventions are Still Needed

    PubMed Central

    2006-01-01

    From 2002 to 2005, two literature reviews identified a number of reproductive-health issues that appeared to be relatively neglected in relation to HIV/AIDS: contraceptive information tailored to the needs of HIV-positive people; voluntary HIV counselling and testing during antenatal care, labour, and delivery; parenting options for HIV-positive people besides pregnancy through unprotected intercourse (i.e. assisted conception and legal adoption or foster care); unwanted pregnancy; and abortion-related care. An additional finding was that stigma and discrimination were frequently cited as barriers to enjoyment of reproductive rights by HIV-positive women. Subsequently, a pilot project was initiated in which non-governmental organizations (NGOs) in developing countries used benchmarks to ascertain whether these neglected issues were addressed in local programmes and interventions serving women affected by HIV and AIDS. The benchmarks also assessed whether policies and programmes paid attention to the human and reproductive rights of HIV-positive women. This paper describes the main findings from the two exercises in relation to contraception for women living with HIV or AIDS, abortion-related care, legal adoption by HIV-positive parents, and reproductive rights. It concludes with a number of recommendations on topics to be incorporated into the international research agenda, policies, and programmes in the field of HIV/AIDS. PMID:17591338

  18. Organizing for ontological change: The kernel of an AIDS research infrastructure

    PubMed Central

    Polk, Jessica Beth

    2015-01-01

    Is it possible to prepare and plan for emergent and changing objects of research? Members of the Multicenter AIDS Cohort Study have been investigating AIDS for over 30 years, and in that time, the disease has been repeatedly transformed. Over the years and across many changes, members have continued to study HIV disease while in the process regenerating an adaptable research organization. The key to sustaining this technoscientific flexibility has been what we call the kernel of a research infrastructure: ongoing efforts to maintain the availability of resources and services that may be brought to bear in the investigation of new objects. In the case of the Multicenter AIDS Cohort Study, these resources are as follows: specimens and data, calibrated instruments, heterogeneous experts, and participating cohorts of gay and bisexual men. We track three ontological transformations, examining how members prepared for and responded to changes: the discovery of a novel retroviral agent (HIV), the ability to test for that agent, and the transition of the disease from fatal to chronic through pharmaceutical intervention. Respectively, we call the work, ‘technologies’, and techniques of adapting to these changes, ‘repurposing’, ‘elaborating’, and ‘extending the kernel’. PMID:26477206

  19. Satellite remote sensing, biodiversity research and conservation of the future

    PubMed Central

    Pettorelli, Nathalie; Safi, Kamran; Turner, Woody

    2014-01-01

    Assessing and predicting ecosystem responses to global environmental change and its impacts on human well-being are high priority targets for the scientific community. The potential for synergies between remote sensing science and ecology, especially satellite remote sensing and conservation biology, has been highlighted by many in the past. Yet, the two research communities have only recently begun to coordinate their agendas. Such synchronization is the key to improving the potential for satellite data effectively to support future environmental management decision-making processes. With this themed issue, we aim to illustrate how integrating remote sensing into ecological research promotes a better understanding of the mechanisms shaping current changes in biodiversity patterns and improves conservation efforts. Added benefits include fostering innovation, generating new research directions in both disciplines and the development of new satellite remote sensing products. PMID:24733945

  20. Future Research Directions in Asthma. An NHLBI Working Group Report.

    PubMed

    Levy, Bruce D; Noel, Patricia J; Freemer, Michelle M; Cloutier, Michelle M; Georas, Steve N; Jarjour, Nizar N; Ober, Carole; Woodruff, Prescott G; Barnes, Kathleen C; Bender, Bruce G; Camargo, Carlos A; Chupp, Geoff L; Denlinger, Loren C; Fahy, John V; Fitzpatrick, Anne M; Fuhlbrigge, Anne; Gaston, Ben M; Hartert, Tina V; Kolls, Jay K; Lynch, Susan V; Moore, Wendy C; Morgan, Wayne J; Nadeau, Kari C; Ownby, Dennis R; Solway, Julian; Szefler, Stanley J; Wenzel, Sally E; Wright, Rosalind J; Smith, Robert A; Erzurum, Serpil C

    2015-12-01

    Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma. PMID:26305520

  1. Future Applications of Remote Sensing to Archeological Research

    NASA Technical Reports Server (NTRS)

    Sever, Thomas L.

    2003-01-01

    Archeology was one of the first disciplines to use aerial photography in its investigations at the turn of the 20th century. However, the low resolution of satellite technology that became available in the 1970 s limited their application to regional studies. That has recently changed. The arrival of the high resolution, multi-spectral capabilities of the IKONOS and QUICKBIRD satellites and the scheduled launch of new satellites in the next few years provides an unlimited horizon for future archeological research. In addition, affordable aerial and ground-based remote sensing instrumentation are providing archeologists with information that is not available through traditional methodologies. Although many archeologists are not yet comfortable with remote sensing technology a new generation has embraced it and is accumulating a wealth of new evidence. They have discovered that through the use of remote sensing it is possible to gather information without disturbing the site and that those cultural resources can be monitored and protected for the future.

  2. A broadband characterisation of Martian soil analogues. Electrical properties as an aid for future Mars exploration

    NASA Astrophysics Data System (ADS)

    Stiegler, Alexander; Kargl, Guenter

    We report on laboratory investigations on the electrical properties of Martian soil analogue materials in a broadband frequency range (1 Hz -20 MHz) in comparison and complementary to previous work. The presented data were acquired with a high-precision impedance spectrometer and with a potential planetary mission instrument which covers a narrower frequency range. A profound knowledge of the electrical characteristics of Martian soil and sub-soil layers may provide a more comprehensive view on data collected in the past as well as data probably obtained in future. Therefore, we present the frequency dependent electrical properties of several Martian soil simulants, as e.g. JSC-Mars 1, Salten Skov, and suitable local materials. The broadband measurements were performed with a high-precision impedance spectrometer. Additional measurements with the Permittivity Probe (PP), a part of the HP3 instrument designed for the ExoMars/Humboldt Station, are presented. As a bore hole type instrument PP is intended to perform subsoil measurements during and after penetration into the ground. With a comparable wide frequency range of 4 -20000 Hz PP could provide huge information in future planetary space missions presenting ground truth for orbiting radar instruments. In the working frequency range of PP special interest will also be given to the electrical properties of water and dry-ice layers.

  3. Space facilities: Meeting future needs for research, development, and operations

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The National Facilities Study (NFS) represents an interagency effort to develop a comprehensive and integrated long-term plan for world-class aeronautical and space facilities that meet current and projected needs for commercial and government aerospace research and development and space operations. At the request of NASA and the DOD, the National Research Council's Committee on Space Facilities has reviewed the space related findings of the NFS. The inventory of more than 2800 facilities will be an important resource, especially if it continues to be updated and maintained as the NFS report recommends. The data in the inventory provide the basis for a much better understanding of the resources available in the national facilities infrastructure, as well as extensive information on which to base rational decisions about current and future facilities needs. The working groups have used the inventory data and other information to make a set of recommendations that include estimates of cast savings and steps for implementation. While it is natural that the NFS focused on cost reduction and consolidations, such a study is most useful to future planning if it gives equal weight to guiding the direction of future facilities needed to satisfy legitimate national aspirations. Even in the context of cost reduction through facilities closures and consolidations, the study is timid about recognizing and proposing program changes and realignments of roles and missions to capture what could be significant savings and increased effectiveness. The recommendations of the Committee on Space Facilities are driven by the clear need to be more realistic and precise both in recognizing current incentives and disincentives in the aerospace industry and in forecasting future conditions for U.S. space activities.

  4. Identifying Future Scientists: Predicting Persistence into Research Training

    PubMed Central

    2007-01-01

    This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end, and 8–12 months after their research experience. Of more than 200 themes considered, five characteristics predicted those students who went on to Ph.D. and M.D./Ph.D. training or to M.D. training intending to do research: 1) Curiosity to discover the unknown, 2) Enjoyment of problem solving, 3) A high level of independence, 4) The desire to help others indirectly through research, and 5) A flexible, minimally structured approach to the future. Web-based surveys with different students confirmed the high frequency of curiosity and/or problem solving as the primary reason students planned research careers. No evidence was found for differences among men, women, and minority and nonminority students. Although these results seem logical compared with successful scientists, their constancy, predictive capabilities, and sharp contrast to students who chose clinical medicine were striking. These results provide important insights into selection and motivation of potential biomedical scientists and the early experiences that will motivate them toward research careers. PMID:18056303

  5. Identifying future scientists: predicting persistence into research training.

    PubMed

    McGee, Richard; Keller, Jill L

    2007-01-01

    This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end, and 8-12 months after their research experience. Of more than 200 themes considered, five characteristics predicted those students who went on to Ph.D. and M.D./Ph.D. training or to M.D. training intending to do research: 1) Curiosity to discover the unknown, 2) Enjoyment of problem solving, 3) A high level of independence, 4) The desire to help others indirectly through research, and 5) A flexible, minimally structured approach to the future. Web-based surveys with different students confirmed the high frequency of curiosity and/or problem solving as the primary reason students planned research careers. No evidence was found for differences among men, women, and minority and nonminority students. Although these results seem logical compared with successful scientists, their constancy, predictive capabilities, and sharp contrast to students who chose clinical medicine were striking. These results provide important insights into selection and motivation of potential biomedical scientists and the early experiences that will motivate them toward research careers. PMID:18056303

  6. Future Directions for Research in Autism Spectrum Disorders

    PubMed Central

    Damiano, Cara R.; Mazefsky, Carla A.; White, Susan W.; Dichter, Gabriel S.

    2014-01-01

    This article suggests future directions for research aimed at improved understanding of the etiology and pathophysiology of autism spectrum disorder (ASD) as well as pharmacologic and psychosocial interventions for ASD across the lifespan. The past few years have witnessed unprecedented transformations in the understanding of ASD neurobiology, genetics, early identification, and early intervention. However, recent increases in ASD prevalence estimates highlight the urgent need for continued efforts to translate novel ASD discoveries into effective interventions for all individuals with ASD. In this article we highlight promising areas for ongoing and new research expected to quicken the pace of scientific discovery and ultimately the translation of research findings into accessible and empirically supported interventions for those with ASD. We highlight emerging research in the following domains as particularly promising and pressing: (1) preclinical models; (2) experimental therapeutics; (3) early identification and intervention; (4) psychiatric comorbidities and the Research Domain Criteria (RDoC) initiative; (5) ecological momentary assessment; (6) neurotechnologies; and (7) the needs of adults with ASD. Increased research emphasis in these areas has the potential to hasten the translation of knowledge on the etiological mechanisms of ASD to psychosocial and biological interventions to reduce the burden of ASD on affected individuals and their families. PMID:25216048

  7. Genes and elite athletes: a roadmap for future research.

    PubMed

    Eynon, Nir; Ruiz, Jonatan R; Oliveira, José; Duarte, José Alberto; Birk, Ruth; Lucia, Alejandro

    2011-07-01

    There is compelling evidence that genetic factors influence several phenotype traits related to physical performance and training response as well as to elite athletic status. Previous case-control studies showed that ∼20 genetic variants seem to be associated with elite endurance athletic status. The present review aims to introduce novel methodological approaches in the field of sports genetics research, which can be applied in the near future to analyse the genotype profile associated with elite athletic status. These include genotype-phenotype association studies using gene expression analysis, analysis of post-transcriptional factors, particularly microRNAs, genome-wide scan linkage or genome-wide association studies, and novel algorithm approaches, such as 'genotype scores'. Several gaps in the current body of knowledge have been identified including, among others: small sample size of most athletic cohorts, lack of corroboration with replication cohorts of different ethnic backgrounds (particularly, made up of non-Caucasian athletes), the need of research accounting for the potential role of epigenetics in elite athletic performance, and also the need for future models that take into account the association between athletic status and complex gene-gene and gene-environment interactions. Some recommendations are provided to minimize research limitations in the field of sport genetics. PMID:21540342

  8. Genes and elite athletes: a roadmap for future research

    PubMed Central

    Eynon, Nir; Ruiz, Jonatan R; Oliveira, José; Duarte, José Alberto; Birk, Ruth; Lucia, Alejandro

    2011-01-01

    Abstract There is compelling evidence that genetic factors influence several phenotype traits related to physical performance and training response as well as to elite athletic status. Previous case-control studies showed that ∼20 genetic variants seem to be associated with elite endurance athletic status. The present review aims to introduce novel methodological approaches in the field of sports genetics research, which can be applied in the near future to analyse the genotype profile associated with elite athletic status. These include genotype–phenotype association studies using gene expression analysis, analysis of post-transcriptional factors, particularly microRNAs, genome-wide scan linkage or genome-wide association studies, and novel algorithm approaches, such as ‘genotype scores’. Several gaps in the current body of knowledge have been indentified including, among others: small sample size of most athletic cohorts, lack of corroboration with replication cohorts of different ethnic backgrounds (particularly, made up of non-Caucasian athletes), the need of research accounting for the potential role of epigenetics in elite athletic performance, and also the need for future models that take into account the association between athletic status and complex gene–gene and gene–environment interactions. Some recommendations are provided to minimize research limitations in the field of sport genetics. PMID:21540342

  9. Foresight scanning: future directions of clinical and pharmaceutical research.

    PubMed

    Foster, Brian C

    2008-01-01

    Foresight Scanning: Future Directions of Clinical and Pharmaceutical Research. Brian C. Foster, Therapeutic Products Directorate, Health Canada, Ottawa, Ontario, Canada ABSTRACT The Canadian Society for Pharmaceutical Sciences Satellite Symposium on Foresight Scanning, May 26 and 27, 2008, Nordegg, Alberta, Canada, focussed on the future directions of clinical and pharmaceutical research. The symposium brought together a group of clinicians, regulatory scientists, researchers and students to examine where clinical, pharmaceutical, and regulatory science might be in 10 to 15 years. Industry, regulatory, analytical, and clinical perspectives were presented and discussed, as well as the impact of exogenous (indirect) and endogenous (direct) change drivers. Unconditional funding was provided by Bayer HealthCare; they had no input on the direction of the meeting or selection of speakers. It was envisioned that the more important endogenous drivers may not be new information or changes in technology, policy, regulation, or health care delivery, but amplification of long-term underlying trends by emergence of new technologies, convergence of existing technologies or new communication and collaboration vehicles such as Web 2.0. PMID:19183518

  10. Future Challenges and Opportunities in Online Prescription Drug Promotion Research

    PubMed Central

    Southwell, Brian G.; Rupert, Douglas J.

    2016-01-01

    Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions. PMID:26927597

  11. Burden of disease--implications for future research.

    PubMed

    Michaud, C M; Murray, C J; Bloom, B R

    2001-02-01

    One overall challenge for public health and medicine in the future is to allocate available resources effectively to reduce major causes of disease burden globally and to decrease health disparities between poor and affluent populations. The major risk factors for death and disability worldwide are malnutrition; poor water supply, sanitation, and personal and domestic hygiene; unsafe sexual behavior; tobacco use; alcohol use; occupational hazards; hypertension; physical inactivity; illicit drugs; and air pollution. The challenge for research in the 21st century is to maintain and improve life expectancy and the quality of life that was achieved for most of the world's population during the 20th century. PMID:11176854

  12. Questions raised over future of UK research council

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2010-02-01

    Five senior physicists have written to the UK science minister, Lord Drayson, about the "dismal future" for researchers in the country in the wake of a £40m shortfall in the budget of the Science and Technology Facilities Council (STFC). The physicists, who chair the STFC's five advisory panels, have also called for structural reforms to be made to the council. They warn that unless the government takes action to reverse the situation, the UK will be "perceived as an untrustworthy partner in global projects" and predict that a brain drain of the best UK scientists to positions overseas will ensue.

  13. Research planning for the future of psychiatric diagnosis.

    PubMed

    Regier, D A; Kuhl, E A; Narrow, W E; Kupfer, D J

    2012-10-01

    More than 10 years prior to the anticipated 2013 publication of DSM-5, processes were set in motion to assess the research and clinical issues that would best inform future diagnostic classification of mental disorders. These efforts intended to identify the clinical and research needs within various populations, examine the current state of the science to determine the empirical evidence for improving criteria within and across disorders, and stimulate research in areas that could potentially provide evidence for change. In the second phase of the revision process, the American Psychiatric Institute for Research and Education (APIRE) recently completed the 5-year international series of 13 diagnostic conferences convened by APA/APIRE in collaboration with the World Health Organization and the National Institutes of Health (NIH), under a cooperative grant funded by the NIH. From these conferences, the DSM-5 Task Force and Work Groups have developed plans for potential revisions for DSM-5, including the incorporation of dimensional approaches within and across diagnostic groups to clarify heterogeneity, improve diagnostic validity, and enhance clinical case conceptualization. Use of dimensions for measurement-based care has been shown to be feasible in psychiatric and primary care settings and may inform monitoring of disorder threshold, severity, and treatment outcomes. The integration of dimensions with diagnostic categories represents an exciting and potentially transformative approach for DSM-5 to simultaneously address DSM-IV's clinical short-comings and create novel pathways for research in neurobiology, genetics, and psychiatric epidemiology. PMID:21676595

  14. [10 years' research in the social sciences on AIDS in Burkina Faso. Elements for prevention].

    PubMed

    Desclaux, A

    1997-01-01

    The first cases of AIDS in Burkina Faso were reported in 1986. During the past ten years, there have been several types of research conducted in Burkina Faso in the field of social sciences, including KABP, focus groups, and ethnographic studies. This article reviews approximately 100 publications and presents the results most relevant to prevention. Although general knowledge of the disease, its transmission and means of protection has improved, part of the population remains poorly informed; erroneous ideas remain prevalent and certain concepts, for example asymptomatic infection, are ignored. Young women in rural areas have the poorest knowledge. Understanding the information is conditioned by underlying perceptions of blood and physiology, the "components of the person", pre-existent and sexually transmitted diseases, and modes of transmission. Research on sexuality has elucidated the age at which individuals become sexually active, and paramatrimonial practices. The prevalence of STD is high. STD are mostly treated by traditional practitioners or by automedication. Family planning is insufficiently developed. AIDS prevention should be integrated into wider considerations of reproductive health. The popular perception that "Others" are responsible for bringing AIDS into the country has often been reinforced by health messages. Consequently, people do not sufficiently consider themselves vulnerable to HIV infection. The populations that are most vulnerable, for various reasons that have been analysed, include young girls and women, married women, prostitutes, truck drivers, and young men from rural areas. The message "Fidelity or condom" has been widely used. However, it has hindered the generalisation of the use of condoms, because asking for a condom consequently implies distrust of the partner. The interpretation of fidelity is diverse, and many people who choose this means of prevention believe erroneously that they are protected. Studies of the social

  15. Research on computer aided testing of pilot response to critical in-flight events

    NASA Technical Reports Server (NTRS)

    Giffin, W. C.; Rockwell, T. H.; Smith, P. J.

    1984-01-01

    Experiments on pilot decision making are described. The development of models of pilot decision making in critical in flight events (CIFE) are emphasized. The following tests are reported on the development of: (1) a frame system representation describing how pilots use their knowledge in a fault diagnosis task; (2) assessment of script norms, distance measures, and Markov models developed from computer aided testing (CAT) data; and (3) performance ranking of subject data. It is demonstrated that interactive computer aided testing either by touch CRT's or personal computers is a useful research and training device for measuring pilot information management in diagnosing system failures in simulated flight situations. Performance is dictated by knowledge of aircraft sybsystems, initial pilot structuring of the failure symptoms and efficient testing of plausible causal hypotheses.

  16. Geriatric epilepsy: research and clinical directions for the future.

    PubMed

    Roberson, Erik D; Hope, Omotola A; Martin, Roy C; Schmidt, Dieter

    2011-09-01

    There is a growing awareness of the need for improved treatment and care of older adults with epilepsy. The present review article highlights key clinical and research issues in the emerging field of geriatric epilepsy. Drs. Martin and Schmidt explore the scope of the problems in the field, outline topic areas including cognitive health/dementia, and diagnostic challenges, and also present important research questions that should be considered for the future. As part of this presentation, we will highlight the work of two promising young investigators whose work holds great promise for the field of geriatric epilepsy. Dr. Roberson will discuss his work focusing on the relationship of epilepsy and cognitive impairment, particularly as it relates to Alzheimer's disease pathology including tau and its role in epileptiform activity. Dr. Hope will outline key issues, as well as her work, relating to defining and measuring quality care in geriatric epilepsy. PMID:21596624

  17. What is "neuromarketing"? A discussion and agenda for future research.

    PubMed

    Lee, Nick; Broderick, Amanda J; Chamberlain, Laura

    2007-02-01

    Recent years have seen advances in neuroimaging to such an extent that neuroscientists are able to directly study the frequency, location, and timing of neuronal activity to an unprecedented degree. However, marketing science has remained largely unaware of such advances and their huge potential. In fact, the application of neuroimaging to market research--what has come to be called "neuromarketing"--has caused considerable controversy within neuroscience circles in recent times. This paper is an attempt to widen the scope of neuromarketing beyond commercial brand and consumer behaviour applications, to include a wider conceptualisation of marketing science. Drawing from general neuroscience and neuroeconomics, neuromarketing as a field of study is defined, and some future research directions are suggested. PMID:16769143

  18. Suggested future directions in high-speed transition experimental research

    NASA Technical Reports Server (NTRS)

    Bushnell, Dennis

    1990-01-01

    Historical developments in the area of high-speed experimental transition research are outlined, and future directions in this area as determined by the panel membership are listed. The directions include measurement and modeling of initial disturbance fields, both in ground facilities and flight, for all modes; development of advanced high-speed instrumentation for disturbance field measurements, measurements of the details of receptivity in multitudinous flows; further development and use of high-speed quiet tunnels; stability and transition studies for multitudinous flows; detailed studies of the transitional region for boundary layers, free flows, vortices separated flows, corner flows, etc.; and studies of flow-chemistry effects on transition phenomena. Applied research such areas as the physics of perforated-surface suction stabilization and the resolution of anomalies in the existing high-speed database is also suggested.

  19. Future opportunities for photovoltaic materials and device research

    SciTech Connect

    Deb, S.K. )

    1994-06-30

    The semiconductor material science and associated device technologies have entered into a new era, almost a revolutionary period. The use of sophisticated computation techniques has given theoreticians the predictive power for novel materials architecture; the experimentalists have the ability to grow materials and devices under carefully controlled conditions and manipulate materials on an atomic scale; and the powerful analytical tools have enabled us to gain insight on the surface, interface, and bulk properties of materials and devices with a high degree of precision. These have opened up some opportunities for doing some very exciting materials and device research in the area of semiconductor materials, in general, and photovoltaic (PV) materials and devices, in particular. In this brief review, a global view of semiconductor materials for PV applications will be taken and an attempt will be made to identify future research opportunities.

  20. Postoperative ileus: mechanisms and future directions for research.

    PubMed

    Vather, Ryash; O'Grady, Greg; Bissett, Ian P; Dinning, Phil G

    2014-05-01

    Postoperative ileus (POI) is an abnormal pattern of gastrointestinal motility characterized by nausea, vomiting, abdominal distension and/or delayed passage of flatus or stool, which may occur following surgery. Postoperative ileus slows recovery, increases the risk of developing postoperative complications and confers a significant financial load on healthcare institutions. The aim of the present review is to provide a succinct overview of the clinical features and pathophysiological mechanisms of POI, with final comment on selected directions for future research.Terminology used when describing POI is inconsistent, with little differentiation made between the obligatory period of gut dysfunction seen after surgery ('normal POI') and the more clinically and pathologically significant entity of a 'prolonged POI'. Both normal and prolonged POI represent a fundamentally similar pathophysiological phenomenon. The aetiology of POI is postulated to be multifactorial, with principal mediators being inflammatory cell activation, autonomic dysfunction (both primarily and as part of the surgical stress response), agonism at gut opioid receptors, modulation of gastrointestinal hormone activity and electrolyte derangements. A final common pathway for these effectors is impaired contractility and motility and gut wall oedema. There are many potential directions for future research. In particular, there remains scope to accurately characterize the gastrointestinal dysfunction that underscores an ileus, development of an accurate risk stratification tool will facilitate early implementation of preventive measures and clinical appraisal of novel therapeutic strategies that target individual pathways in the pathogenesis of ileus warrant further investigation. PMID:24754527

  1. Future Directions in Early Cystic Fibrosis Lung Disease Research

    PubMed Central

    Banks-Schlegel, Susan; Accurso, Frank J.; Boucher, Richard C.; Cutting, Garry R.; Engelhardt, John F.; Guggino, William B.; Karp, Christopher L.; Knowles, Michael R.; Kolls, Jay K.; LiPuma, John J.; Lynch, Susan; McCray, Paul B.; Rubenstein, Ronald C.; Singh, Pradeep K.; Sorscher, Eric; Welsh, Michael

    2012-01-01

    Since the 1989 discovery that mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), there has been substantial progress toward understanding the molecular basis for CF lung disease, leading to the discovery and development of new therapeutic approaches. However, the earliest impact of the loss of CFTR function on airway physiology and structure and its relationship to initial infection and inflammation are poorly understood. Universal newborn screening for CF in the United States represents an unprecedented opportunity for investigating CF clinical manifestations very early in life. Recently developed animal models with pulmonary phenotypic manifestations also provide a window into the early consequences of this genetic disorder. For these reasons, the National Heart, Lung, and Blood Institute (NHLBI) convened a working group of extramural experts, entitled “Future Research Directions in Early CF Lung Disease” on September 21–22, 2010, to identify future research directions of great promise in CF. The priority areas identified included (1) exploring pathogenic mechanisms of early CF lung disease; (2) leveraging newborn screening to elucidate the natural history of early lung disease; (3) developing a spectrum of biomarkers of early lung disease that reflects CF pathophysiology, clinical outcome, and response to treatment; (4) exploring the role of genetics/genomics (e.g., modifier genes, gene–environmental interactions, and epigenetics) in early CF pathogenesis; (5) defining early microbiological events in CF lung disease; and (6) elucidating the initial airway inflammatory, remodeling, and repair mechanisms in CF lung disease. PMID:22312017

  2. Compact Toroidal Hybrid Research Program: Recent Progress and Future Plans

    NASA Astrophysics Data System (ADS)

    Maurer, D. A.; Cianciosa, M.; Hanson, J. D.; Hartwell, G. J.; Hebert, J. D.; Herfindal, J. L.; Knowlton, S. F.; Archmiller, M. C.; Traverso, P.; Pandya, M.; Ma, X.

    2012-10-01

    Understanding the control and avoidance of major disruptions in current carrying toroidal plasmas is important in mitigating the effects of rapid loss of confinement in future devices. The Compact Toroidal Hybrid (CTH) experiment is investigating the passive avoidance of disruptions with the addition of a small amount of vacuum transform provided by external coils. In ohmically-driven stellarator plasmas no disruptions of any kind are observed if the vacuum transform exceeds ˜ 0.11. Recent progress on the suppression of low-qa (high a), density limit, and vertically unstable plasma disruptions is overviewed. Interpretation of these results makes use of 3D equilibrium reconstructions using the V3FIT code [1]. Several new diagnostic tools have recently been developed and implemented on CTH. These new research tools include multi-chord interferometry, bolometry, Hα emission detection, a two-color soft x-ray camera, and upgraded magnetic sensor arrays. In addition to these diagnostic improvements, a new 200 kW gyrotron system will provide additional heating power for stellarator target plasmas. Future research directions and plans will also be discussed. [4pt] [1] J. D. Hanson, S. P. Hirshman, S. F. Knowlton, L. L. Lao, E. A. Lazarus, J. M. Shields, Nucl. Fusion, 49 (2009) 075031

  3. Building a Bright Future. The Hydro Research Foundation's Fellowship Program

    SciTech Connect

    Vaughn, Brenna; Linke, Deborah M.

    2015-12-29

    The Hydro Fellowship Program (program) began as an experiment to discover whether the hydropower industry could find mechanisms to attract new entrants through conducting relevant research to benefit the industry. This nationwide, new-to-the-world program was started through funding from the Wind and Water Power Technologies Office of the Energy Efficiency and Renewable Energy (EERE) Office of the Department of Energy (DOE). Between 2010-2015, the Hydro Research Foundation (HRF) designed and implemented a program to conduct valuable research and attract new entrants to the hydro workforce. This historic grant has empowered and engaged industry members from 25 organizations by working with 91 students and advisors at 24 universities in 19 states. The work funded answered pressing research needs in the fields of civil, mechanical, environmental, and electrical engineering, as well as law, energy engineering and materials innovation. In terms of number of individuals touched through funding, 148 individuals were supported by this work through direct research, mentorship, oversight of the work, partnerships and the day-to-day program administration. Based on the program results, it is clear that the funding achieved the hoped-for outcomes and has the capacity to draw universities into the orbit of hydropower and continue the conversation about industry research and development needs. The Foundation has fostered unique partnerships at the host universities and has continued to thrive with the support of the universities, advisors, industry and the DOE. The Foundation has demonstrated industry support through mentorships, partnerships, underwriting the costs and articulating the universities’ support through in-kind cost sharing. The Foundation recommends that future work be continued to nurture these graduate level programs using the initial work and improvements in the successor program, the Research Awards Program, while stimulating engagement of academia at the

  4. A Systematic Review of the Psychometric Properties of the Sexual Relationship Power Scale in HIV/AIDS Research

    PubMed Central

    McMahon, James M.; Volpe, Ellen M.; Klostermann, Keith; Trabold, Nicole; Xue, Ying

    2014-01-01

    The Sexual Relationship Power Scale (SRPS) was developed over a decade ago to address the lack of reliable and valid measures of relationship power in social, behavioral and medical research. The SRPS and its two subscales (relationship control [RC], decision-making dominance [DMD]) have been used extensively in the field of HIV prevention and sexual risk behavior. We performed a systematic review of the psychometric properties of the SRPS and subscales as reported in the HIV/AIDS literature from 2000 to 2012. A total of 54 published articles were identified that reported reliability or construct validity estimates of the scales. Description of the psychometric properties of the SRPS and subscales are reported according to study population, and several cross-population trends were identified. In general, the SRPS and RC subscale exhibited sound psychometric properties across multiple study populations and research settings. By contrast, the DMD subscale had relatively weak psychometric properties, especially when used with specific populations and research settings. Factors that influenced the psychometric properties of the various scales and subscales included the study population, mean age of the sample, number of items retained in the scale, and modifications to the original scales. We conclude with recommendations for (a) the application and use of the SRPS and subscales, (b) reporting of psychometric properties of the scales in the literature, and (c) areas for future research. PMID:25331613

  5. Juvenile fibromyalgia: current status of research and future developments

    PubMed Central

    Kashikar-Zuck, Susmita; Ting, Tracy V.

    2015-01-01

    Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition most commonly affecting adolescent girls. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep, headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. In the past few years, there has been a greater focus on understanding JFM in adolescents. Research studies have provided insight into the clinical characteristics of this condition and its effect on both short-term and long-term psychosocial and physical functioning. The importance of early and effective intervention is being recognized, as research has shown that symptoms of JFM tend to persist and do not resolve over time as was previously believed. Efforts to improve treatments for JFM are underway, and new evidence strongly points to the potential benefits of cognitive–behavioural therapy on improving mood and daily functioning. Research into pharmacotherapy and other nonpharmacological options is in progress. Advancements in the understanding of adult fibromyalgia have paved the way for future studies on diagnosis, assessment and management of JFM. This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study. PMID:24275966

  6. Water, Society and the future of water resources research (Invited)

    NASA Astrophysics Data System (ADS)

    Brown, C. M.

    2013-12-01

    The subject of water and society is broad, but at heart is the study of water as a resource, essential to human activities, a vital input to food and energy production, the sustaining medium for ecosystems and yet also a destructive hazard. Society demands, withdraws, competes, uses and wastes the resource in dynamic counterpart. The science of water management emerges from this interface, a field at the nexus of engineering and geoscience, with substantial influence from economics and other social sciences. Within this purview are some of the most pressing environmental questions of our time, such as adaptation to climate change, direct and indirect connections between water and energy policy, the continuing dependence of agriculture on depletion of the world's aquifers, the conservation or preservation of ecosystems within increasingly human-influenced river systems, and food security and poverty reduction for the earth's poorest inhabitants. This presentation will present and support the hypothesis that water resources research is a scientific enterprise separate from, yet closely interrelated to, hydrologic science. We will explore the scientific basis of water resources research, review pressing research questions and opportunities, and propose an action plan for the advancement of the science of water management. Finally, the presentation will propose a Chapman Conference on Water and Society: The Future of Water Resources Research in the spring of 2015.

  7. Past, present and future of laser fusion research

    NASA Astrophysics Data System (ADS)

    Yamanaka, C.

    1996-05-01

    The concept of laser fusion was devised very shortly after the invention of laser. In 1972, the Institute of Laser Engineering, Osaka University was established by the author in accordance with the Edward Teller's special lecture on ``New Internal Combustion Engine'' for IQEC at Montreal which predicted the implosion fusion. In 1975 we invented the so called indirect drive fusion concept ``Cannonball Target'' which became later to be recognize as a same concept of ``Hohlraum Target'' from Livermore. As well known, ICF research in the US had been veiled for a long time due to the defense classification. While researchers from Japan, Germany and elsewhere have concentrated the efforts to investigate the inertial fusion energy which seems to be very interesting for a future civil energy. They were publishing their own works not only on the direct implosion scheme but also the indirect implosion experiment. These advanced results often frustrated the US researchers who were not allowed to talk about the details of their works. In 1988, international members of the ICF research society including the US scientists gathered together at ECLIM to discuss the necessity of freedom in the ICF research and concluded to make a statement ``Madrid Manifest'' which requested the declassification of the ICF research internationally. After 6 years of halt, the US DOE decided to declassify portions of the program as a part of secretary Hazel O'Leary's openness initiative. The first revealed presentation from the US was done at Seville 1994, which however were well known already. Classification impeded the progress by restricting the flow of information and did not allow the ICF work to compete by the open scientific security. The implosion experiments by GEKKO XII Osaka demonstrated a high temperature compression of DT fuel up to 10 keV, neutron yield 1013 and a high density compression of CDT hollow shell pellet to reach 1000 g/cm3 respectively. These results gave us a strong

  8. Past, present and future of laser fusion research

    SciTech Connect

    Yamanaka, C.

    1996-05-01

    The concept of laser fusion was devised very shortly after the invention of laser. In 1972, the Institute of Laser Engineering, Osaka University was established by the author in accordance with the Edward Teller{close_quote}s special lecture on {open_quote}{open_quote}New Internal Combustion Engine{close_quote}{close_quote} for IQEC at Montreal which predicted the implosion fusion. In 1975 we invented the so called indirect drive fusion concept {open_quote}{open_quote}Cannonball Target{close_quote}{close_quote} which became later to be recognize as a same concept of {open_quote}{open_quote}Hohlraum Target{close_quote}{close_quote} from Livermore. As well known, ICF research in the US had been veiled for a long time due to the defense classification. While researchers from Japan, Germany and elsewhere have concentrated the efforts to investigate the inertial fusion energy which seems to be very interesting for a future civil energy. They were publishing their own works not only on the direct implosion scheme but also the indirect implosion experiment. These advanced results often frustrated the US researchers who were not allowed to talk about the details of their works. In 1988, international members of the ICF research society including the US scientists gathered together at ECLIM to discuss the necessity of freedom in the ICF research and concluded to make a statement {open_quote}{open_quote}Madrid Manifest{close_quote}{close_quote} which requested the declassification of the ICF research internationally. After 6 years of halt, the US DOE decided to declassify portions of the program as a part of secretary Hazel O{close_quote}Leary{close_quote}s openness initiative. The first revealed presentation from the US was done at Seville 1994, which however were well known already. Classification impeded the progress by restricting the flow of information and did not allow the ICF work to compete by the open scientific security. (Abstract Truncated)

  9. Concepts of hydrological connectivity: Research approaches, pathways and future agendas

    NASA Astrophysics Data System (ADS)

    Bracken, L. J.; Wainwright, J.; Ali, G. A.; Tetzlaff, D.; Smith, M. W.; Reaney, S. M.; Roy, A. G.

    2013-04-01

    For effective catchment management and intervention in hydrological systems a process-based understanding of hydrological connectivity is required so that: i) conceptual rather than solely empirical understanding drives how systems are interpreted; and ii) there is an understanding of how continuous flow fields develop under different sets of environmental conditions to enable managers to know when, where and how to intervene in catchment processes successfully. In order to direct future research into process-based hydrological connectivity this paper: i) evaluates the extent to which different concepts of hydrological connectivity have emerged from different approaches to measure and predict flow in different environments; ii) discusses the extent to which these different concepts are mutually compatible; and iii) assesses further research to contribute to a unified understanding of hydrological processes. Existing research is categorised into five different approaches to investigating hydrological connectivity: i) evaluating soil-moisture patterns (soil-moisture connectivity); ii) understanding runoff patterns and processes on hillslopes (flow-process connectivity); iii) investigating topographic controls (terrain-connectivity) including the impact of road networks on hydrological connectivity and catchment runoff; iv) developing models to explore and predict hydrological connectivity; and v) developing indices of hydrological connectivity. Analysis of published research suggests a relationship between research group, approach, geographic setting and the interpretation of hydrological connectivity. For further understanding of hydrological connectivity our knowledge needs to be developed using a range of techniques and approaches, there should be common understandings between researchers approaching the concept from different perspectives, and these meanings need to be communicated effectively with those responsible for land management.

  10. Hearing Aids and Music

    PubMed Central

    Chasin, Marshall; Russo, Frank A.

    2004-01-01

    Historically, the primary concern for hearing aid design and fitting is optimization for speech inputs. However, increasingly other types of inputs are being investigated and this is certainly the case for music. Whether the hearing aid wearer is a musician or merely someone who likes to listen to music, the electronic and electro-acoustic parameters described can be optimized for music as well as for speech. That is, a hearing aid optimally set for music can be optimally set for speech, even though the converse is not necessarily true. Similarities and differences between speech and music as inputs to a hearing aid are described. Many of these lead to the specification of a set of optimal electro-acoustic characteristics. Parameters such as the peak input-limiting level, compression issues—both compression ratio and knee-points—and number of channels all can deleteriously affect music perception through hearing aids. In other cases, it is not clear how to set other parameters such as noise reduction and feedback control mechanisms. Regardless of the existence of a “music program,” unless the various electro-acoustic parameters are available in a hearing aid, music fidelity will almost always be less than optimal. There are many unanswered questions and hypotheses in this area. Future research by engineers, researchers, clinicians, and musicians will aid in the clarification of these questions and their ultimate solutions. PMID:15497032

  11. A memory and organizational aid improves AD research consent capacity: Results of a randomized, controlled trial

    PubMed Central

    Rubright, Jonathan; Sankar, Pamela; Casarett, David J; Gur, Ruben; Xie, Sharon X; Karlawish, Jason

    2010-01-01

    Objectives AD patients' early and progressive cognitive impairments hinder their capacity to provide informed consent. Unfortunately, the limited research on techniques to improve capacity has shown mixed results. Therefore, we tested whether a memory and organizational aid improves AD patient performance on measures of capacity and competency to give informed consent. Design, Setting, and Participants AD patients randomly assigned to standard consent, or standard plus a memory and organizational aid. Intervention Memory and organizational aid summarized at a 6th grade reading level the content of information mandated under the Common Rule's informed consent disclosure requirements. Measurements Three psychiatrists without access to patient data independently reviewed MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) interview transcripts to judge whether the patient was capable of providing informed consent. The agreement of at least two of three experts defined a participant as capable of providing informed consent. Secondary outcomes are MacCAT-CR measures of understanding, appreciation and reasoning, and comparison to cognitively normal older adult norms. Results AD intervention and control groups were similar in terms of age, education, and cognitive status. The intervention group was more likely to be judged competent than control group and had higher scores on MacCAT-CR measure of understanding. The intervention had no effect on measures of appreciation or reasoning. Conclusions A consent process that addresses an AD patients' deficits in memory and attention can improve capacity to give informed consent for early phase AD research. The results also validate the MacCAT-CR as an instrument to measure capacity, especially the understanding subscale. PMID:20808101

  12. Internet Research: Implications for The Future of Health Care

    PubMed Central

    Shortliffe, Ted

    1999-01-01

    The phenomenal growth in Internet usage, largely due to the success of the World Wide Web, has stressed the international networking infrastructure in ways that were never contemplated when the early ARPAnet emerged from research laboratories in the 1970s. Some of the challenges are logistical and legal, and have to do with management of domain names, intellectual-property agreements, and international business activities. Others are technical, resulting both because we are envisioning applications that the current Internet cannot support, and because the existing infrastructure cannot scale to a world in which a huge portion of the world's population is online and individual homes and businesses may have IP addresses for tens of electronic devices, such as appliances, heating systems, or security alarms. In this presentation, I will discuss some of the US research and testbed activities that are currently underway in an effort to respond to the technical challenges. These include the Internet-2 testbed created by a consortium of academic institutions, and the federal government's Next Generation Internet research initiative. I will explain the difference between these two programs and identify some of the technical requirements other than a simple increase in bandwidth that have been identified for the evolving Internet. This will lead to a discussion of the limitations of the current Internet that have constrained its use in health care and that accordingly help to define the networking research agenda that is of greatest importance to the biomedical community. Policy and regulatory issues that arise because of health care's use of the Internet will also be discussed, as will those technical requirements that may be unique to biomedical applications. One goal of the discussion will be to motivate an international discussion of the ways in which the medical informatics community should be engaged in both basic and applied research in the area of networking and the

  13. Childhood overweight: a contextual model and recommendations for future research.

    PubMed

    Davison, K K; Birch, L L

    2001-08-01

    The prevalence of overweight among children has doubled within the past two decades. Increases in the rate of childhood overweight are of particular concern due to the negative health and psychological effects noted among overweight children. As shown by previous research, the development of childhood overweight involves a complex set of factors from multiple contexts that interact with each other to place a child at risk of overweight. This multifaceted system can be conceptualized using Ecological Systems Theory (EST). EST highlights the importance of considering the context(s), or ecological niche, in which a person is located in order to understand the emergence of a particular characteristic. In the case of a child, the ecological niche includes the family and the school, which are in turn embedded in larger social contexts including the community and society at large. In this review, EST is used as a framework with which to summarize research assessing predictors of childhood overweight. Specifically, child characteristics that place children at risk of the development of overweight (including dietary intake, physical activity, and sedentary behaviour) will be reviewed while taking into consideration the influence of the familial environment, the school environment, and the community and larger social environments. It is concluded that future research needs to adopt a broader contextual approach in order to understand and intervene against the processes leading to the development of overweight among children and that the use of theories or paradigms such as EST will facilitate developing and testing models of causal processes. PMID:12120101

  14. Science and Observation Recommendations for Future NASA Carbon Cycle Research

    NASA Technical Reports Server (NTRS)

    McClain, Charles R.; Collatz, G. J.; Kawa, S. R.; Gregg, W. W.; Gervin, J. C.; Abshire, J. B.; Andrews, A. E.; Behrenfeld, M. J.; Demaio, L. D.; Knox, R. G.

    2002-01-01

    Between October 2000 and June 2001, an Agency-wide planning, effort was organized by elements of NASA Goddard Space Flight Center (GSFC) to define future research and technology development activities. This planning effort was conducted at the request of the Associate Administrator of the Office of Earth Science (Code Y), Dr. Ghassem Asrar, at NASA Headquarters (HQ). The primary points of contact were Dr. Mary Cleave, Deputy Associate Administrator for Advanced Planning at NASA HQ (Headquarters) and Dr. Charles McClain of the Office of Global Carbon Studies (Code 970.2) at GSFC. During this period, GSFC hosted three workshops to define the science requirements and objectives, the observational and modeling requirements to meet the science objectives, the technology development requirements, and a cost plan for both the science program and new flight projects that will be needed for new observations beyond the present or currently planned. The plan definition process was very intensive as HQ required the final presentation package by mid-June 2001. This deadline was met and the recommendations were ultimately refined and folded into a broader program plan, which also included climate modeling, aerosol observations, and science computing technology development, for contributing to the President's Climate Change Research Initiative. This technical memorandum outlines the process and recommendations made for cross-cutting carbon cycle research as presented in June. A separate NASA document outlines the budget profiles or cost analyses conducted as part of the planning effort.

  15. Historical Perspective and Future Directions in Platelet Research

    PubMed Central

    Coller, Barry S.

    2011-01-01

    Platelets are a remarkable mammalian adaptation that are required for human survival by virtue of their ability to prevent and arrest bleeding. Ironically, however, in the past century, the platelets’ hemostatic activity became maladaptive for the increasingly large percentage of individuals who develop age-dependent progressive atherosclerosis. As a result, platelets also make a major contribution to ischemic thrombotic vascular disease, the leading cause of death worldwide. In this brief review, I provide historical descriptions of a highly selected group of topics to provide a framework for understanding our current knowledge and the trends that are likely to continue into the future of platelet research. For convenience, I separate the eras of platelet research into the “Descriptive Period” extending from ~1880-1960 and the “Mechanistic Period” encompassing the past ~50 years since 1960. We currently are reaching yet another inflection point, as there is a major shift from a focus on traditional biochemistry and cell and molecular biology to an era of single molecule biophysics, single cell biology, single cell molecular biology, structural biology, computational simulations, and the high-throughput, data-dense techniques collectively named with the “omics” postfix. Given the progress made in understanding, diagnosing, and treating many rare and common platelet disorders during the past 50 years, I think it appropriate to consider it a Golden Age of Platelet Research and to recognize all of the investigators who have made important contributions to this remarkable achievement. PMID:21781274

  16. Past missions - the best way to train future planetary researchers

    NASA Astrophysics Data System (ADS)

    Kozlova, Natalia; Solodovnikova, Anastasiya; Zubarev, Anatoly; Garov, Andrey; Patraty, Vyacheslav; Kokhanov, Alexander; Karachevtseva, Irina; Nadezhdina, Irina; Konopikhin, Anatoly; Oberst, Juergen

    2015-04-01

    Practice shows that it is much more interesting and useful to learn from real examples than on imaginary tasks from exercise books. The more technologies and software improves and develops, the more information and new products can be obtained from new processing of archive information collected by past planetary missions. So at MIIGAiK we carry out modern processing of lunar panoramic images obtained by Soviet Lunokhod missions (1970-1973). During two years of the study, which is a part of PRoViDE project (http://www.provide-space.eu/), many students, PhD students, young scientists, as well as professors have taken part in this research. Processing of the data obtained so long ago requires development of specific methods, techniques, special software and extraordinary approach. All these points help to interest young people in planetary science and develop their skills as researchers. Another advantage of data from previous missions is that you can compare your results with the ones obtained during the mission. This also helps to test the developed techniques and software on real data and adjust them for implementation in future missions. The work on Lunokhod data processing became the basis of master and PhD theses of MIIGAiK students and scientists at MExLab. Acknowledgments: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement No 312377 PRoViDE.

  17. Advances in low-level jet research and future prospects

    NASA Astrophysics Data System (ADS)

    Liu, Hongbo; He, Mingyang; Wang, Bin; Zhang, Qinghong

    2014-02-01

    The low-level jet (LLJ) is closely related to severe rainfall events, air pollution, wind energy utilization, aviation safety, sandstorms, forest fire, and other weather and climate phenomena. Therefore, it has attracted considerable attention since its discovery. Scientists have carried out many studies on LLJs and made significant achievements during the past five or six decades. This article summarizes and assesses the current knowledge on this subject, and focuses in particular on three aspects: 1) LLJ classification, definition, distribution, and structure; 2) LLJ formation and evolutionary mechanisms; and 3) relationships between LLJ and rainfall, as well as other interdisciplinary fields. After comparing the status of LLJ research at home (China) and abroad, we then discuss the shortcomings of LLJ research in China. We suggest that this includes: coarse definitions of the LLJ, lack of observations and inadequate quality control, few thorough explorations of LLJ characteristics and formation mechanisms, and limited studies in interdisciplinary fields. The future prospects for several LLJ research avenues are also speculated.

  18. Childhood overweight: a contextual model and recommendations for future research

    PubMed Central

    Davison, K. K.; Birch, L. L.

    2008-01-01

    Summary The prevalence of overweight among children has doubled within the past two decades. Increases in the rate of childhood overweight are of particular concern due to the negative health and psychological effects noted among overweight children. As shown by previous research, the development of childhood overweight involves a complex set of factors from multiple contexts that interact with each other to place a child at risk of overweight. This multifaceted system can be conceptualized using Ecological Systems Theory (EST). EST highlights the importance of considering the context(s), or ecological niche, in which a person is located in order to understand the emergence of a particular characteristic. In the case of a child, the ecological niche includes the family and the school, which are in turn embedded in larger social contexts including the community and society at large. In this review, EST is used as a framework with which to summarize research assessing predictors of childhood overweight. Specifically, child characteristics that place children at risk of the development of overweight (including dietary intake, physical activity, and sedentary behaviour) will be reviewed while taking into consideration the influence of the familial environment, the school environment, and the community and larger social environments. It is concluded that future research needs to adopt a broader contextual approach in order to understand and intervene against the processes leading to the development of overweight among children and that the use of theories or paradigms such as EST will facilitate developing and testing models of causal processes. PMID:12120101

  19. Recent Advances in PV Research and Future Directions

    NASA Astrophysics Data System (ADS)

    Deb, Satyen K.

    1998-04-01

    The photovoltaic technology is making a major thrust in the commercial arena with 1997 worldwide production of PV modules reaching over 125 MW and growing at the rate of 20-25semiconductor materials and devices are emerging as strong contenders for PV applications even though silicon is still the 'work-horse' of the industry. Ultra-high efficiency solar cells fabricated from gallium arsenide (GaAs) and its ternary alloys like gallium indium phosphide (GaInP2) are finding applications in space technology. Enormous progress has also been made on various thin-film solar cell technologies, which offer the promise for substantially reducing the cost of PV systems. Some of the leading contenders are amorphous and polycrystalline silicon, compound semiconductor thin films such as copper indium diselenide (CuInSe2) based alloys, and cadmium telluride (CdTe) thin films. Exciting new developments are happening in the use of nano-particle semiconductor materials like titanium dioxide (TiO2) for low-cost PV devices. Intense research on these and other materials and devices is making a strong impact on the technology. In this presentation, a brief overview of recent advances in PV research will b e made and the trends and opportunities for future research directions will be identified.

  20. Tendon Mechanobiology: Current Knowledge and Future Research Opportunities

    PubMed Central

    Lavagnino, Michael; Wall, Michelle E.; Little, Dianne; Banes, Albert J.; Guilak, Farshid; Arnoczky, Steven P.

    2015-01-01

    Tendons mainly function as load-bearing tissues in the muscloskeletal system, transmitting loads from muscle to bone. Tendons are dynamic structures that respond to the magnitude, direction, frequency, and duration of physiologic as well as pathologic mechanical loads via complex interactions between cellular pathways and the highly specialized extracellular matrix. This paper reviews the evolution and current knowledge of mechanobiology in tendon development, homeostasis, disease, and repair. In addition, we review several novel mechanotransduction pathways that have been identified recently in other tissues and cell types, providing potential research opportunities in the field of tendon mechanobiology. We also highlight current methods, models, and technologies being used in a wide variety of mechanobiology research that could be investigated in the context of their potential applicability for answering some of the fundamental unanswered questions in this field. The article concludes with a review of the major questions and future goals discussed during the recent ORS/ISMMS New Frontiers in Tendon Research Conference held September 10–11, 2014 in New York City. PMID:25763779

  1. Substance Use Disorders and HIV/AIDS Prevention and Treatment Intervention: Research and Practice Considerations

    PubMed Central

    CAMPBELL, AIMEE N. C.; TROSS, SUSAN; CALSYN, DONALD A.

    2013-01-01

    Social workers are often on the front lines of the HIV/AIDS epidemic – delivering prevention education and interventions, offering or linking individuals to HIV testing, and working to improve treatment access, retention, and adherence, especially among vulnerable populations. Individuals with substance use disorders face additional challenges to reducing sexual and drug risk behaviors, as well as barriers to testing, treatment, and antiretroviral therapy adherence. This paper presents current data on HIV transmission and research evidence on prevention and intervention with substance abusers and highlights how individual social workers can take advantage of this knowledge in practice and through adoption and implementation within organizations. PMID:23731423

  2. Marketing strategies for recruiting gay men into AIDS research and education projects.

    PubMed

    Silvestre, A; Lyter, D W; Rinaldo, C R; Kingsley, L A; Forrester, R; Huggins, J

    1986-01-01

    Recruiting gay and bisexual men into AIDS-related research and education programs will become increasingly common as federal, state and local funds become available. The Pitt Men's Study, a study of the natural history of Human Immunodeficiency Virus (HIV) infection, developed a recruitment strategy based on marketing principles. These techniques allowed the study to target particular gay and bisexual groups for inclusion. 1718 gay and bisexual men were recruited. Non-whites and unemployed men were targeted and recruited in numbers comparable to their representation in the larger community. PMID:3558875

  3. Langley Research Center Utility Risk from Future Climate Change

    NASA Technical Reports Server (NTRS)

    De Young, Russell J.; Ganoe, Rene

    2015-01-01

    The successful operation of NASA Langley Research Center (LaRC) depends on services provided by several public utility companies. These include Newport News Waterworks, Dominion Virginia Power, Virginia Natural Gas and Hampton Roads Sanitation District. LaRC's plan to respond to future climate change should take into account how these companies plan to avoid interruption of services while minimizing cost to the customers. This report summarizes our findings from publicly available documents on how each company plans to respond. This will form the basis for future planning for the Center. Our preliminary findings show that flooding and severe storms could interrupt service from the Waterworks and Sanitation District but the potential is low due to plans in place to address climate change on their system. Virginia Natural Gas supplies energy to produce steam but most current steam comes from the Hampton trash burning plant, thus interruption risk is low. Dominion Virginia Power does not address climate change impacts on their system in their public reports. The potential interruption risk is considered to be medium. The Hampton Roads Sanitation District is projecting a major upgrade of their system to mitigate clean water inflow and infiltration. This will reduce infiltration and avoid overloading the pump stations and treatment plants.

  4. Computerized clinical guidelines: current status & principles for future research.

    PubMed

    Kondylakis, Haridimos; Tsiknakis, Manolis

    2012-01-01

    Although it is widely accepted that the adoption of computerized clinical guidelines would improve the quality of the provided health care, their influence in the daily practice is limited. In this paper we provide insights on the core topics related to computer interpretable clinical guidelines and we present shortly the main approaches in the area. Then we discuss the current limitations, and we present three simple principles that according to our view should be adopted to enhance the penetration of computerized clinical guidelines in the health care organizations. The overall goal of this paper is not only to give readers a quick overview of the works in the area, but also to provide necessary insights for the practical understanding of the issues involved and draw directions for future research and development activities. PMID:22874227

  5. Cognitive behavioral therapy: current status and future research directions.

    PubMed

    McMain, Shelley; Newman, Michelle G; Segal, Zindel V; DeRubeis, Robert J

    2015-01-01

    Cognitive behavioral therapy (CBT), an umbrella term that includes a diverse group of treatments, is defined by a strong commitment to empiricism. While CBT has a robust empirical base, areas for improvement remain. This article reviews the status of the current empirical base and its limitations, and presents future directions for advancement of the field. Ultimately, studies are needed that will identify the predictors, mediators, and moderators of treatment response in order to increase knowledge on how to personalize interventions for each client and to strengthen the impact of CBT. Efforts to advance the dissemination and implementation of CBT, innovative approaches such as practice-oriented research, and the advantages of incorporating new and existing technologies, are discussed as well. PMID:25689506

  6. Trends in research and development for future detectors

    NASA Astrophysics Data System (ADS)

    Cattai, Ariella

    2013-12-01

    Development of novel detector concepts has always played a major role in supporting and enabling scientific research. In the forthcoming phase of high energy physics (HEP), the design and development of new detectors and detector concepts will be even more important than it was in the past owing to the harsh environmental conditions and the challenging requests imposed by the physicists' needs for: improved spatial and time resolution, innovative functions, acquisition speed, radiation tolerance, minimal power consumption, robustness and reliability, minimal material and more. This overview addresses the challenges that upgrades and future projects in HEP will impose in terms of novel technologies and stresses the detectors' potential and limitations in attempting to achieve the scientific goals. In addition the increasingly strong dependence on large-scale industrial production and industrial development, especially in the area of integrated electronics, sensors and large complex systems will be addressed.

  7. A bright future for bioluminescent imaging in viral research

    PubMed Central

    Coleman, Stewart M; McGregor, Alistair

    2015-01-01

    Summary Bioluminescence imaging (BLI) has emerged as a powerful tool in the study of animal models of viral disease. BLI enables real-time in vivo study of viral infection, host immune response and the efficacy of intervention strategies. Substrate dependent light emitting luciferase enzyme when incorporated into a virus as a reporter gene enables detection of bioluminescence from infected cells using sensitive charge-coupled device (CCD) camera systems. Advantages of BLI include low background, real-time tracking of infection in the same animal and reduction in the requirement for larger animal numbers. Transgenic luciferase-tagged mice enable the use of pre-existing nontagged viruses in BLI studies. Continued development in luciferase reporter genes, substrates, transgenic animals and imaging systems will greatly enhance future BLI strategies in viral research. PMID:26413138

  8. Summary: present and future challenges for stem cell research.

    PubMed

    Hogan, B L M

    2008-01-01

    Stem cell research is being driven forward at an intense pace by creative interactions among scientists working in different fields. These include developmental and reproductive biology, regeneration, genomics, live cell imaging, RNA biology, and cancer biology, to name a few. Numerous model systems and techniques are being exploited, and lab scientists are teaming up with bioengineers and clinicians. The ferment of ideas that makes the field so exciting was in full evidence throughout the Symposium. However, many challenges still need to be overcome to translate basic discoveries into therapeutic outcomes that will save lives and fulfill the promises that have been made. This chapter summarizes some of the highlights of the Symposium and indicates future directions that are being taken by leaders in the field. PMID:19329577

  9. High Density Electroencephalography in Sleep Research: Potential, Problems, Future Perspective

    PubMed Central

    Lustenberger, Caroline; Huber, Reto

    2012-01-01

    High density EEG (hdEEG) during sleep combines the superior temporal resolution of EEG recordings with high spatial resolution. Thus, this method allows a topographical analysis of sleep EEG activity and thereby fosters the shift from a global view of sleep to a local one. HdEEG allowed to investigate sleep rhythms in terms of their characteristic behavior (e.g., the traveling of slow waves) and in terms of their relationship to cortical functioning (e.g., consciousness and cognitive abilities). Moreover, recent studies successfully demonstrated that hdEEG can be used to study brain functioning in neurological and neuro-developmental disorders, and to evaluate therapeutic approaches. This review highlights the potential, the problems, and future perspective of hdEEG in sleep research. PMID:22593753

  10. Past, present and future research directions with Pichia anomala.

    PubMed

    Passoth, Volkmar; Olstorpe, Matilda; Schnürer, Johan

    2011-01-01

    The first International Pichia anomala Symposium provided a survey of past, recent and ongoing research on this yeast. The research community working with this yeast has focussed on several areas. Based on molecular data, a revision of the taxonomy is required: the name P. anomala is no longer applicable, as the genus Pichia is polyphyletic. The current debate centres on whether the yeast should be designated as Wickerhamomyces anomalus or if the previous name, Hansenula anomala, should be re-instated. The anti-microbial activities of this yeast received considerable attention during the symposium. H. anomala has been extensively studied as a biopreservation agent in many different post-harvest systems. Several mechanisms account for its anti-microbial activities, including the production of killer proteins and toxic volatile metabolites. Anti-idiotypic antibodies generating an "internal image" of a killer protein have been found to possess therapeutic activity against a broad range of microorganisms. A great diversity of H. anomala strains was reported at the symposium. Strains have been isolated from several food and feed systems and even from the intestine and reproductive organs of a malaria vector (Anopheles stephensi). Feed and food supplemented with certain H. anomala strains show an improved quality due, for example, to the addition of advantageous proteins and phytase activity. However, a number of apparent opportunistic pathogenic strains have also been isolated. Strain differentiation, especially the recognition of potentially pathogenic isolates, is an important challenge for the future commercialisation of this yeast. Future industrial and agricultural application of this yeast also raises questions of the economics of large-scale production, its survival during storage (formulation) and of safety regulations, all of which require further investigation. PMID:20924674

  11. Exploring intentions to discriminate against patients living with HIV/AIDS among future healthcare providers in Malaysia

    PubMed Central

    Earnshaw, Valerie A.; Jin, Harry; Wickersham, Jeffrey; Kamarulzaman, Adeeba; John, Jacob; Altice, Frederick L.

    2015-01-01

    OBJECTIVES Stigma towards people living with HIV/AIDS (PLWHA) is strong in Malaysia. Although stigma has been understudied, it may be a barrier to treating the approximately 81 000 Malaysian PLWHA. The current study explores correlates of intentions to discriminate against PLWHA among medical and dental students, the future healthcare providers of Malaysia. METHODS An online, cross-sectional survey of 1296 medical and dental students was conducted in 2012 at seven Malaysian universities; 1165 (89.9%) completed the survey and were analysed. Sociodemographic characteristics, stigma-related constructs and intentions to discriminate against PLWHA were measured. Linear mixed models were conducted, controlling for clustering by university. RESULTS The final multivariate model demonstrated that students who intended to discriminate more against PLWHA were female, less advanced in their training, and studying dentistry. They further endorsed more negative attitudes towards PLWHA, internalised greater HIV-related shame, reported more HIV-related fear and disagreed more strongly that PLWHA deserve good care. The final model accounted for 38% of the variance in discrimination intent, with 10% accounted for by sociodemographic characteristics and 28% accounted for by stigma-related constructs. CONCLUSIONS It is critical to reduce stigma among medical and dental students to eliminate intentions to discriminate and achieve equitable care for Malaysian PLWHA. Stigma-reduction interventions should be multipronged, addressing attitudes, internalised shame, fear and perceptions of deservingness of care. PMID:24666546

  12. Ethical Issues in mHealth Research Involving Persons Living with HIV/AIDS and Substance Abuse

    PubMed Central

    Labrique, Alain B.; Kirk, Gregory D.; Westergaard, Ryan P.; Merritt, Maria W.

    2013-01-01

    We aim to raise awareness and stimulate dialogue among investigators and research ethics committees regarding ethical issues that arise specifically in the design and conduct of mHealth research involving persons living with HIV/AIDS and substance abuse. Following a brief background discussion of mHealth research in general, we offer a case example to illustrate the characteristics of mHealth research involving people living with HIV/AIDS and substance abuse. With reference to a well-established systematic general ethical framework for biomedical research with human participants, we identify a range of ethical issues that have particular salience for the protection of participants in mHealth research on HIV/AIDS and substance abuse. PMID:24171110

  13. Water research to support society: past, present and future

    NASA Astrophysics Data System (ADS)

    Arheimer, Berit

    2014-05-01

    Scientists are nowadays claiming that we are leaving the geological era of Holocene and have entered the Anthropocene (the Age of Man), a man-made world, in which humans are not observers of nature but central to its workings and commanding the planet's features, fluxes and material cycles. Both the hydrological and the biogeochemical cycles are radically changed compared to pristine conditions and the biodiversity is radically declining as the human population is growing. The co-evolution between society and environment is complex and not always reversible and we therefore need more research on effects of change to raise awareness and prepare for consequences. Many problems caused by humans are also well recognized and can be remediated. As the society develops also the environmental concerns normally becomes more important leading to remedial measures and pollution control. The change in water quality for many rivers world-wide shows similar flux over time related to level of economic development, going from deterioration to recovery as an effect of improved water management. Water management is of major importance for sustainable development, both for efficient water use and ecosystem protection. Water management should be based on (i) best available site information and (ii) best practices from understanding cause-effect relationships; yet, large areas still remains un-monitored and the relations between processes are complex and often not well understood. These knowledge gaps hamper the societal development and are thus two key challenges to address in the hydrological sciences initiative Panta Rhei. This presentation will address some of these challenges for water research in the past, present and future. Hydrology is by tradition an applied research, in which scientific questions co-evolve with societal needs. This will be exemplified this by giving a brief overview of the shift in research questions at one national institute, SMHI, during the last 100 years

  14. Photovoltaic manufacturing: Present status, future prospects, and research needs

    SciTech Connect

    Wolden, C.A.; Fthenakis, V.; Kurtin, J.; Baxter, J.; Repins, I.; Shasheen, S.; Torvik, J.; Rocket, A.; Aydil, E.

    2011-03-29

    In May 2010 the United States National Science Foundation sponsored a two-day workshop to review the state-of-the-art and research challenges in photovoltaic (PV) manufacturing. This article summarizes the major conclusions and outcomes from this workshop, which was focused on identifying the science that needs to be done to help accelerate PV manufacturing. A significant portion of the article focuses on assessing the current status of and future opportunities in the major PV manufacturing technologies. These are solar cells based on crystalline silicon (c-Si), thin films of cadmium telluride (CdTe), thin films of copper indium gallium diselenide, and thin films of hydrogenated amorphous and nanocrystalline silicon. Current trends indicate that the cost per watt of c-Si and CdTe solar cells are being reduced to levels beyond the constraints commonly associated with these technologies. With a focus on TW/yr production capacity, the issue of material availability is discussed along with the emerging technologies of dye-sensitized solar cells and organic photovoltaics that are potentially less constrained by elemental abundance. Lastly, recommendations are made for research investment, with an emphasis on those areas that are expected to have cross-cutting impact.

  15. Implementation of proteomics for cancer research: past, present, and future.

    PubMed

    Karimi, Parisa; Shahrokni, Armin; Ranjbar, Mohammad R Nezami

    2014-01-01

    Cancer is the leading cause of the death, accounts for about 13% of all annual deaths worldwide. Many different fields of science are collaborating together studying cancer to improve our knowledge of this lethal disease, and find better solutions for diagnosis and treatment. Proteomics is one of the most recent and rapidly growing areas in molecular biology that helps understanding cancer from an omics data analysis point of view. The human proteome project was officially initiated in 2008. Proteomics enables the scientists to interrogate a variety of biospecimens for their protein contents and measure the concentrations of these proteins. Current necessary equipment and technologies for cancer proteomics are mass spectrometry, protein microarrays, nanotechnology and bioinformatics. In this paper, we provide a brief review on proteomics and its application in cancer research. After a brief introduction including its definition, we summarize the history of major previous work conducted by researchers, followed by an overview on the role of proteomics in cancer studies. We also provide a list of different utilities in cancer proteomics and investigate their advantages and shortcomings from theoretical and practical angles. Finally, we explore some of the main challenges and conclude the paper with future directions in this field. PMID:24761843

  16. 50 years of Arabidopsis research: highlights and future directions.

    PubMed

    Provart, Nicholas J; Alonso, Jose; Assmann, Sarah M; Bergmann, Dominique; Brady, Siobhan M; Brkljacic, Jelena; Browse, John; Chapple, Clint; Colot, Vincent; Cutler, Sean; Dangl, Jeff; Ehrhardt, David; Friesner, Joanna D; Frommer, Wolf B; Grotewold, Erich; Meyerowitz, Elliot; Nemhauser, Jennifer; Nordborg, Magnus; Pikaard, Craig; Shanklin, John; Somerville, Chris; Stitt, Mark; Torii, Keiko U; Waese, Jamie; Wagner, Doris; McCourt, Peter

    2016-02-01

    922 I. 922 II. 922 III. 925 IV. 925 V. 926 VI. 927 VII. 928 VIII. 929 IX. 930 X. 931 XI. 932 XII. 933 XIII. Natural variation and genome-wide association studies 934 XIV. 934 XV. 935 XVI. 936 XVII. 937 937 References 937 SUMMARY: The year 2014 marked the 25(th) International Conference on Arabidopsis Research. In the 50 yr since the first International Conference on Arabidopsis Research, held in 1965 in Göttingen, Germany, > 54 000 papers that mention Arabidopsis thaliana in the title, abstract or keywords have been published. We present herein a citational network analysis of these papers, and touch on some of the important discoveries in plant biology that have been made in this powerful model system, and highlight how these discoveries have then had an impact in crop species. We also look to the future, highlighting some outstanding questions that can be readily addressed in Arabidopsis. Topics that are discussed include Arabidopsis reverse genetic resources, stock centers, databases and online tools, cell biology, development, hormones, plant immunity, signaling in response to abiotic stress, transporters, biosynthesis of cells walls and macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association studies and natural variation, gene regulatory networks, modeling and systems biology, and synthetic biology. PMID:26465351

  17. Peaking for optimal performance: Research limitations and future directions.

    PubMed

    Pyne, David B; Mujika, Iñigo; Reilly, Thomas

    2009-02-01

    A key element of the physical preparation of athletes is the taper period in the weeks immediately preceding competition. Existing research has defined the taper, identified various forms used in contemporary sport, and examined the prescription of training volume, load, intensity, duration, and type (progressive or step). Current limitations include: the lack of studies on team, combative, racquet, and precision (target) sports; the relatively small number of randomized controlled trials; the narrow focus on a single competition (single peak) compared with multiple peaking for weekly, multi-day or multiple events; and limited understanding of the physiological, neuromuscular, and biomechanical basis of the taper. Future research should address these limitations, together with the influence of prior training on optimal tapering strategies, and the interactions between the taper and long-haul travel, heat, and altitude. Practitioners seek information on how to prescribe tapers from season to season during an athlete's career, or a team's progression through a domestic league season, or multi-year Olympic or World Cup cycle. Practical guidelines for planning effective tapers for the Vancouver 2010 and London 2012 Olympics will evolve from both experimental investigations and modelling of successful tapers currently employed in a wide range of sports. PMID:19153861

  18. Future developments in brain-machine interface research

    PubMed Central

    Lebedev, Mikhail A; Tate, Andrew J; Hanson, Timothy L; Li, Zheng; O'Doherty, Joseph E; Winans, Jesse A; Ifft, Peter J; Zhuang, Katie Z; Fitzsimmons, Nathan A; Schwarz, David A; Fuller, Andrew M; An, Je Hi; Nicolelis, Miguel A L

    2011-01-01

    Neuroprosthetic devices based on brain-machine interface technology hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurologic diseases and limb loss. During the last decade, considerable progress has been achieved in this multidisciplinary research, mainly in the brain-machine interface that enacts upper-limb functionality. However, a considerable number of problems need to be resolved before fully functional limb neuroprostheses can be built. To move towards developing neuroprosthetic devices for humans, brain-machine interface research has to address a number of issues related to improving the quality of neuronal recordings, achieving stable, long-term performance, and extending the brain-machine interface approach to a broad range of motor and sensory functions. Here, we review the future steps that are part of the strategic plan of the Duke University Center for Neuroengineering, and its partners, the Brazilian National Institute of Brain-Machine Interfaces and the École Polytechnique Fédérale de Lausanne (EPFL) Center for Neuroprosthetics, to bring this new technology to clinical fruition. PMID:21779720

  19. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research.

    PubMed

    Gillette-Guyonnet, Sophie; Secher, Marion; Vellas, Bruno

    2013-03-01

    The prevention of dementias, such as Alzheimer's disease (AD), is a growing public health concern, due to a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiological research, including modifiable lifestyle factors such as diet. Current epidemiological data are in favour of a protective role of certain micronutrients (B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish) in the prevention of cognitive decline and dementia/AD. Some factors have been targeted by interventions tested in randomized controlled trials (RCTs), but many of the results are conflicting with observational evidence. Epidemiological analysis of the relations between nutrient consumption and cognitive decline is complex and it is highly unlikely that a single component plays a major role. In addition, since multiple factors across the life course influence brain function in late life, multidomain interventions might be more promising in the prevention of cognitive decline and dementia/AD. Designing such trials remains very challenging for researchers. The main objective of this paper is to review the epidemiologic data linking potential protective factors to cognitive decline or dementia/AD, focusing particularly on the roles of adiposity, caloric restriction, micro (group B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish). Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed. PMID:23384081

  20. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

    PubMed Central

    Gillette‐Guyonnet, Sophie; Secher, Marion; Vellas, Bruno

    2013-01-01

    The prevention of dementias, such as Alzheimer's disease (AD), is a growing public health concern, due to a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiological research, including modifiable lifestyle factors such as diet. Current epidemiological data are in favour of a protective role of certain micronutrients (B vitamins related to homocysteine metabolism, the anti‐oxidant vitamins C and E, flavonoids, polyunsatured omega‐3 fatty acids, vitamin D) and macronutrients (fish) in the prevention of cognitive decline and dementia/AD. Some factors have been targeted by interventions tested in randomized controlled trials (RCTs), but many of the results are conflicting with observational evidence. Epidemiological analysis of the relations between nutrient consumption and cognitive decline is complex and it is highly unlikely that a single component plays a major role. In addition, since multiple factors across the life course influence brain function in late life, multidomain interventions might be more promising in the prevention of cognitive decline and dementia/AD. Designing such trials remains very challenging for researchers. The main objective of this paper is to review the epidemiologic data linking potential protective factors to cognitive decline or dementia/AD, focusing particularly on the roles of adiposity, caloric restriction, micro (group B vitamins related to homocysteine metabolism, the anti‐oxidant vitamins C and E, flavonoids, polyunsatured omega‐3 fatty acids, vitamin D) and macronutrients (fish). Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed. PMID:23384081

  1. Munchausen by Internet: Current Research and Future Directions

    PubMed Central

    Taylor, Jacqui

    2012-01-01

    about their health in the online environment. We also suggest directions for future research. PMID:22914203

  2. Proceeding of human exoskeleton technology and discussions on future research

    NASA Astrophysics Data System (ADS)

    Li, Zhiqiang; Xie, Hanxing; Li, Weilin; Yao, Zheng

    2014-05-01

    After more than half a century of intense efforts, the development of exoskeleton has seen major advances, and several remarkable achievements have been made. Reviews of developing history of exoskeleton are presented, both in active and passive categories. Major models are introduced, and typical technologies are commented on. Difficulties in control algorithm, driver system, power source, and man-machine interface are discussed. Current researching routes and major developing methods are mapped and critically analyzed, and in the process, some key problems are revealed. First, the exoskeleton is totally different from biped robot, and relative studies based on the robot technologies are considerably incorrect. Second, biomechanical studies are only used to track the motion of the human body, the interaction between human and machines are seldom studied. Third, the traditional developing ways which focused on servo-controlling have inborn deficiency from making portable systems. Research attention should be shifted to the human side of the coupling system, and the human ability to learn and adapt should play a more significant role in the control algorithms. Having summarized the major difficulties, possible future works are discussed. It is argued that, since a distinct boundary cannot be drawn in such strong-coupling human-exoskeleton system, the more complex the control system gets, the more difficult it is for the user to learn to use. It is suggested that the exoskeleton should be treated as a simple wearable tool, and downgrading its automatic level may be a change toward a brighter research outlook. This effort at simplification is definitely not easy, as it necessitates theoretical supports from fields such as biomechanics, ergonomics, and bionics.

  3. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Cancer.gov

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  4. NIH Research: Dr. Anthony S. Fauci: "An AIDS-free generation is closer than we might think" | NIH MedlinePlus the ...

    MedlinePlus

    ... Javascript on. NIH Research: Dr. Anthony S. Fauci: "An AIDS-free generation is closer than we might think" ... Washington Post . What's the current state of the AIDS epidemic? The number of people contracting HIV infection ...

  5. Review of the Status of Learning in Research on Sport Education: Future Research and Practice

    PubMed Central

    Araújo, Rui; Mesquita, Isabel; Hastie, Peter A.

    2014-01-01

    Research concerning Sport Education’s educational impact has shown unequivocal results according to students’ personal and social development. Nevertheless, research is still sparse with respect to the model’s impact on student learning outcomes. The goal of the present review is to therefore scrutinize what is currently known regarding students’ learning during their participation in Sport Education. This research spans a variety of studies, cross various countries, school grades, the sports studied, as well as the methods applied and dimensions of student learning analyzed. While research on the impact of Sport Education on students’ learning, as well as teachers’ and students’ perceptions about student learning has shown students’ improvements during the participation in Sport Education seasons, there is still considerable variance in these results. For example, some studies report superior learning opportunities to boys and higher skill-level students while other studies have identified superior learning opportunities for girls and lower skill-level students. These inconsistent results can be explained by factors not considered in the Sport Education research, such as the effect of time on students’ learning and the control of the teaching-learning process within Sport Education units. In this review directions for future research and practice are also described. Future research should define, implement, and evaluate protocols for student-coaches’ preparation in order to understand the influence of this issue on students’ learning as well as consider the implementation of hybrid approaches. Moreover, future studies should consider the interaction of gender and skill level and a retention test in the analysis of students’ learning improvements in order to obtain a more realist and complete portrait of the impact of Sport Education. Finally, in order to reach an entirely understanding of the teaching-learning process, it is necessary to

  6. Review of the status of learning in research on sport education: future research and practice.

    PubMed

    Araújo, Rui; Mesquita, Isabel; Hastie, Peter A

    2014-12-01

    Research concerning Sport Education's educational impact has shown unequivocal results according to students' personal and social development. Nevertheless, research is still sparse with respect to the model's impact on student learning outcomes. The goal of the present review is to therefore scrutinize what is currently known regarding students' learning during their participation in Sport Education. This research spans a variety of studies, cross various countries, school grades, the sports studied, as well as the methods applied and dimensions of student learning analyzed. While research on the impact of Sport Education on students' learning, as well as teachers' and students' perceptions about student learning has shown students' improvements during the participation in Sport Education seasons, there is still considerable variance in these results. For example, some studies report superior learning opportunities to boys and higher skill-level students while other studies have identified superior learning opportunities for girls and lower skill-level students. These inconsistent results can be explained by factors not considered in the Sport Education research, such as the effect of time on students' learning and the control of the teaching-learning process within Sport Education units. In this review directions for future research and practice are also described. Future research should define, implement, and evaluate protocols for student-coaches' preparation in order to understand the influence of this issue on students' learning as well as consider the implementation of hybrid approaches. Moreover, future studies should consider the interaction of gender and skill level and a retention test in the analysis of students' learning improvements in order to obtain a more realist and complete portrait of the impact of Sport Education. Finally, in order to reach an entirely understanding of the teaching-learning process, it is necessary to use research designs that

  7. Educational Research Within Postcolonial Africa: A Critique of HIV/AIDS Research in Botswana

    ERIC Educational Resources Information Center

    Chilisa, Bagele

    2005-01-01

    This paper uses the postcolonial lens to highlight that mainstream research in postcolonial societies still ignores, marginalizes and suppresses other knowledge systems and ways of knowing. The marginalization of local knowledge systems, it is argued, was established in the colonial times that relegated all things indigenous or from the colonized…

  8. Future volcanic lake research: revealing secrets from poorly studied lakes

    NASA Astrophysics Data System (ADS)

    Rouwet, D.; Tassi, F.; Mora-Amador, R. A.

    2012-04-01

    Volcanic lake research boosted after the 1986 Lake Nyos lethal gas burst, a limnic rather than volcanic event. This led to the formation of the IAVCEI-Commission on Volcanic Lakes, which grew out into a multi-disciplinary scientific community since the 1990's. At Lake Nyos, a degassing pipe is functional since 2001, and two additional pipes were added in 2011, aimed to prevent further limnic eruption events. There are between 150 and 200 volcanic lakes on Earth. Some acidic crater lakes topping active magmatic-hydrothermal systems are monitored continuously or discontinuously. Such detailed studies have shown their usefulness in volcanic surveillance (e.g. Ruapehu, Yugama-Kusatsu-Shiran, Poás). Others are "Nyos-type" lakes, with possible gas accumulation in bottom waters and thus potentially hazardous. "Nyos-type" lakes tend to remain stably stratified in tropical and sub-tropical climates (meromictic), leading to long-term gas build-up and thus higher potential risk. In temperate climates, such lakes tend to turn over in winter (monomictic), and thus liberating its gas charge yearly. We line out research strategies for the different types of lakes. We believe a complementary, multi-disciplinary approach (geochemistry, geophysics, limnology, biology, statistics, etc.) will lead to new insights and ideas, which can be the base for future following-up and monitoring. After 25 years of pioneering studies on rather few lakes, the scientific community should be challenged to study the many poorly studied volcanic lakes, in order to better constrain the related hazard, based on probabilistic approaches.

  9. Present and Future Automotive Composite Materials Research Efforts at DOE

    SciTech Connect

    Warren, C.D.

    1999-07-03

    Automobiles of the future will be forced to travel fi.uther on a tank of fuel while discharging lower levels of pollutants. Currently, the United States uses in excess of 16.4 million barrels of petroleum per day. Sixty-six percent of that petroleum is used in the transportation of people and goods. Automobiles currently account for just under two-thirds of the nation's gasoline consumptio~ and about one-third of the total United States energy usage. [1] By improving transportation related fiel efficiency, the United States can lessen the impact that emissions have on our environment and provide a cleaner environment for fiture generations. In 1992, The Department of Energy's (DOE) Office of Transportation Materials completed a comprehensive program plan entitled, The Lightweight MateriaIs (LWko Multi-Year Program Plan, for the development of technologies aimed at reducing vehicle mass [2]. This plan was followed in 1997 by the more comprehensive Office of Advanced Automotive Technologies research and development plan titled, Energy Eficient Vehicles for a Cleaner Environment [3] which outlines the department's plans for developing more efficient vehicles during the next ~een years. Both plans identi~ potential applications, technology needs, and R&D priorities. The goal of the Lightweight Materials Program is to develop materials and primary processing methods for the fabrication of lighter weight components which can be incorporated into automotive systems. These technologies are intended to reduce vehicle weight, increase fuel efficiency and decrease emissions. The Lightweight Materials program is jointly managed by the Department of Energy(DOE) and the United States Automotive Materials Partnership (USAMP). Composite materiak program work is coordinated by cooperative research efforts between the DOE and the Automotive Composites Consortium (ACC).

  10. Microbicide acceptability research: current approaches and future directions.

    PubMed

    Mantell, Joanne E; Myer, Landon; Carballo-Diéguez, Alex; Stein, Zena; Ramjee, Gita; Morar, Neetha S; Harrison, Polly F

    2005-01-01

    With growing recognition of the potential value of microbicides for HIV/STI prevention, the importance of the acceptability of this brand-new technology has been widely acknowledged. We review the current body of microbicide acceptability research, characterize the limitations in assessment approaches, and suggest strategies for improvement. Electronic databases and abstracts of recent meetings were searched for acceptability data regarding vaginal and rectal products that may be used for HIV prevention. Of the 61 studies reviewed, more than half assessed acceptability based primarily on the description of a hypothetical microbicide, or with the demonstration of a spermicide or lubricant. Physical characteristics of microbicidal products, their effects after insertion, and their effects on sensation during intercourse (for both partners) were the dimensions most frequently assessed (measured in 77%, 49% and 49% of studies, respectively). Attention to the social context of use was inadequate. As acceptability is likely to be a key determinant in the use-effectiveness of microbicides, in-depth understanding of the social processes that shape microbicide acceptability across diverse populations will become increasingly valuable. This includes exploring the effects that sexual partners, health care providers, and key opinion leaders have on the acceptability of microbicides among women and men, including youth and people living with HIV. Future research will benefit from studies of the acceptability of other contraceptive-barrier methods (especially the female condom), use of an agreed-upon operationalization of acceptability, use of acceptability assessments within clinical trials, expansion of measurement domains, and assessment of changes in perceptions of acceptability and use over time. Failure to understand the key factors associated with microbicide acceptability is likely to hinder the adoption and continued use of products that are effective in preventing HIV

  11. Fog Research: A Review of Past Achievements and Future Perspectives

    NASA Astrophysics Data System (ADS)

    Gultepe, I.; Tardif, R.; Michaelides, S. C.; Cermak, J.; Bott, A.; Bendix, J.; Müller, M. D.; Pagowski, M.; Hansen, B.; Ellrod, G.; Jacobs, W.; Toth, G.; Cober, S. G.

    2007-06-01

    The scientific community that includes meteorologists, physical scientists, engineers, medical doctors, biologists, and environmentalists has shown interest in a better understanding of fog for years because of its effects on, directly or indirectly, the daily life of human beings. The total economic losses associated with the impact of the presence of fog on aviation, marine and land transportation can be comparable to those of tornadoes or, in some cases, winter storms and hurricanes. The number of articles including the word ``fog'' in Journals of American Meteorological Society alone was found to be about 4700, indicating that there is substantial interest in this subject. In spite of this extensive body of work, our ability to accurately forecast/nowcast fog remains limited due to our incomplete understanding of the fog processes over various time and space scales. Fog processes involve droplet microphysics, aerosol chemistry, radiation, turbulence, large/small-scale dynamics, and surface conditions (e.g., partaining to the presence of ice, snow, liquid, plants, and various types of soil). This review paper summarizes past achievements related to the understanding of fog formation, development and decay, and in this respect, the analysis of observations and the development of forecasting models and remote sensing methods are discussed in detail. Finally, future perspectives for fog-related research are highlighted.

  12. Selenium bioavailability: current knowledge and future research requirements.

    PubMed

    Fairweather-Tait, Susan J; Collings, Rachel; Hurst, Rachel

    2010-05-01

    Information on selenium bioavailability is required to derive dietary recommendations and to evaluate and improve the quality of food products. The need for robust data is particularly important in light of recent suggestions of potential health benefits associated with different intakes of selenium. The issue is not straightforward, however, because of large variations in the selenium content of foods (determined by a combination of geologic/environmental factors and selenium supplementation of fertilizers and animal feedstuffs) and the chemical forms of the element, which are absorbed and metabolized differently. Although most dietary selenium is absorbed efficiently, the retention of organic forms is higher than that of inorganic forms. There are also complications in the assessment and quantification of selenium species within foodstuffs. Often, extraction is only partial, and the process can alter the form or forms present in the food. Efforts to improve, standardize, and make more widely available techniques for species quantification are required. Similarly, reliable and sensitive functional biomarkers of selenium status are required, together with improvements in current biomarker methods. This requirement is particularly important for the assessment of bioavailability, because some functional biomarkers respond differently to the various selenium species. The effect of genotype adds a potential further dimension to the process of deriving bioavailability estimates and underlines the need for further research to facilitate the process of deriving dietary recommendations in the future. PMID:20200264

  13. Mitochondrial pyruvate transport: a historical perspective and future research directions

    PubMed Central

    McCommis, Kyle S.; Finck, Brian N.

    2015-01-01

    Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Despite long-standing acceptance that transport of pyruvate into the mitochondrial matrix by a carrier-mediated process is required for the bulk of its metabolism, it has taken almost 40 years to determine the molecular identity of an IMM pyruvate carrier. Our current understanding is that two proteins, mitochondrial pyruvate carriers MPC1 and MPC2, form a hetero-oligomeric complex in the IMM to facilitate pyruvate transport. This step is required for mitochondrial pyruvate oxidation and carboxylation – critical reactions in intermediary metabolism that are dysregulated in several common diseases. The identification of these transporter constituents opens the door to the identification of novel compounds that modulate MPC activity, with potential utility for treating diabetes, cardiovascular disease, cancer, neurodegenerative diseases, and other common causes of morbidity and mortality. The purpose of the present review is to detail the historical, current and future research investigations concerning mitochondrial pyruvate transport, and discuss the possible consequences of altered pyruvate transport in various metabolic tissues. PMID:25748677

  14. [Eating disorders: state of the art research and future challenges].

    PubMed

    Voderholzer, U; Cuntz, U; Schlegl, S

    2012-11-01

    Eating disorders are a common mental disorder during adolescence and young adulthood. While prevalence rates of eating disorders dramatically increased during the second half of the last century, these rates have remained relatively stable over the last 20 years. According to ICD-10 eating disorders are diagnostically categorized as anorexia nervosa, bulimia nervosa and atypical eating disorders or eating disorders not otherwise specified. Concerning the etiology, genetic factors are involved, especially in anorexia nervosa, as well as psychological and sociocultural factors. Evidence-based recommendations are available for the treatment of bulimia nervosa and binge eating disorder and in this context cognitive behavioral therapy is seen as the first choice. In contrast, the state of knowledge concerning the treatment of anorexia nervosa is still limited, especially concerning effective treatments for adults. Recent data only provide evidence for the effectiveness of family therapy for adolescents. Due to the lack of high quality studies, research on therapy for anorexia nervosa is a future challenge. PMID:23104604

  15. Alcohol and NMDA receptor: current research and future direction

    PubMed Central

    Chandrasekar, Raman

    2013-01-01

    The brain is one of the major targets of alcohol actions. Most of the excitatory synaptic transmission in the central nervous system is mediated by N-methyl-D-aspartate (NMDA) receptors. However, one of the most devastating effects of alcohol leads to brain shrinkage, loss of nerve cells at specific regions through a mechanism involving excitotoxicity, oxidative stress. Earlier studies have indicated that chronic exposure to ethanol both in vivo and in vitro, increases NR1 and NR2B gene expression and their polypeptide levels. The effect of alcohol and molecular changes on the regulatory process, which modulates NMDAR functions including factors altering transcription, translation, post-translational modifications, and protein expression, as well as those influencing their interactions with different regulatory proteins (downstream effectors) are incessantly increasing at the cellular level. Further, I discuss the various genetically altered mice approaches that have been used to study NMDA receptor subunits and their functional implication. In a recent countable review, epigenetic dimension (i.e., histone modification-induced chromatin remodeling and DNA methylation, in the process of alcohol related neuroadaptation) is one of the key molecular mechanisms in alcohol mediated NMDAR alteration. Here, I provide a recount on what has already been achieved, current trends and how the future research/studies of the NMDA receptor might lead to even greater engagement with many possible new insights into the neurobiology and treatment of alcoholism. PMID:23754976

  16. Global Alzheimer Research Summit: basic and clinical research: present and future Alzheimer research.

    PubMed

    Gonsalves, Danielle; Jovanovic, Katarina; Da Costa Dias, Bianca; Weiss, Stefan F T

    2012-01-01

    We report here on the proceedings of the Global Alzheimer Summit that took place September 22-23, 2011 in Madrid, Spain. As Alzheimer disease (AD) is the leading cause of neurodegeneration in elderly individuals and as yet has no effective therapeutic option, it continues to stimulate global research interests. At the conference, leaders in the field of AD research provided insights into current developments in various areas of research, namely molecular mechanisms, genetics, novel aspects of AD research and translational research. Emphasis was also placed on the importance of biomarkers in the diagnosis of AD and development of current therapeutic strategies. PMID:22453170

  17. The Women and Infants Demonstration Project: an integrated approach to AIDS prevention and research.

    PubMed

    Terry, M A; Liebman, J; Person, B; Bond, L; Dillard-Smith, C; Tunstall, C

    1999-04-01

    The Women and Infants Demonstration Project is a multisite, behavioral intervention research effort funded by the Centers for Disease Control. The project is evaluating a theory-based, integrated intervention model to increase the use of condoms for prevention of both sexually transmitted diseases (STDs) and unintended pregnancy among women and their partners at risk of infection with HIV. The importance of utilizing carefully targeted, credible and persistent risk reduction interventions to effect lasting behavior change has become evident over the last ten years of the AIDS epidemic. The theory-based intervention components being evaluated in this intervention study involve one-on-one stage-tailored outreach; the development and distribution of community-tailored HIV prevention materials, called role-model stories; and the development of organizational and peer networking, all within a community mobilization framework. This article describes each of the intervention components being evaluated during this 5-year study. Such an intervention effort represents an important contribution in the design of community-level AIDS prevention intervention efforts which support individual-level behavioral changes by women at risk for HIV and other sexually transmitted infections. PMID:10214495

  18. REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

    SciTech Connect

    Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry; Carroll, Sean; Ooguri, Hirosi; Gukov, Sergei; Preskill, John; Hitlin, David G.; Porter, Frank C.; Patterson, Ryan B.; Newman, Harvey B.; Spiropulu, Maria; Golwala, Sunil; Zhu, Ren-Yuan

    2014-08-26

    of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these

  19. Future Research Needs for Long-Term Monitoring Program Design

    NASA Astrophysics Data System (ADS)

    Minsker, B. S.; Dougherty, D. E.; Williams, G.; Davis, C. B.

    2002-05-01

    An ASCE Task Committee is preparing a manual of practice on long-term monitoring (LTM) program design for groundwater (including vadose) systems. The committee has identified several areas for future research and technology transfer that will improve LTM design. LTM is an on-going activity aimed at assessing remediation performance, containment integrity, and/or continued non-contamination of the subsurface and groundwater. LTM has different goals and needs than site characterization, so data collection, analysis, and modeling approaches must evolve to meet these new needs. Many new sensors and field measurement methods for LTM are under development, and research is needed to develop methods to integrate these data sources with more traditional samples drawn from wells to maximize the information extracted from the data. These new methods need to be able to provide information to assess performance of waste management activities and to understand long-term behavior by optimizing the collection and analysis of multiple data types. The effects of different sampling and measurement methods on monitoring results and their implications for the design of LTM programs also require study. Additional research needs include development of methods to assess flow control strategies, to identify monitoring redundancy in fractured media, and to better incorporate uncertainty into the LTM design process. Well-tested, documented, and open datasets are needed to validate and compare the performance of methods. Technology transfer activities must address the need for evolution of regulatory guidance to encompass the types of data analysis that are needed to assess remediation or containment performance, to identify appropriate LTM plans, and to incorporate novel data collection methods that may support better decision quality through the use of more extensive measurements with lower individual precisions than traditional measurements or may measure an indicator parameter rather than

  20. Using Financial Aid to Speed Degree Completion: A Look at MDRC's Research. Issue Focus

    ERIC Educational Resources Information Center

    MDRC, 2016

    2016-01-01

    Financial aid has long been used to increase access to postsecondary education, particularly for underrepresented students. Given the size of the financial aid system and the widespread use of aid, it should also be thought of as a tool to improve academic success and postsecondary completion. Evidence suggests that using additional financial aid…

  1. Student Financial Aid in Maryland: Programs, Trends, and Analysis. Postsecondary Education Research Reports.

    ERIC Educational Resources Information Center

    Breslin, Janice

    Trends in financial aid to students in Maryland colleges and universities are reported. Attention is directed to the distribution of different types of aid to undergraduate and graduate students, and financial aid awarded by type of institution. Characteristics of recipients of Guaranteed Student Loans, General State Scholarships, and Senatorial…

  2. Financial Aid Policy: Lessons from Research. NBER Working Paper No. 18710

    ERIC Educational Resources Information Center

    Dynarski, Susan; Scott-Clayton, Judith

    2013-01-01

    In the nearly fifty years since the adoption of the Higher Education Act of 1965, financial aid programs have grown in scale, expanded in scope, and multiplied in form. As a result, financial aid has become the norm among college enrollees. The increasing size and complexity of the nation's student aid system has generated questions about…

  3. Brain oscillations forever--neurophysiology in future research of child psychiatric problems.

    PubMed

    Rothenberger, Aribert

    2009-01-01

    For decades neurophysiology has successfully contributed to research and clinical care in child psychiatry. Recently, methodological progress has led to a revival of interest in brain oscillations (i.e., a band of periodic neuronal frequencies with a wave-duration from milliseconds to several seconds which may code and decode information). These oscillations will nurture future information processing research during normal and pathological brain development, allowing us to investigate basic neuronal connectivity as well as interactions of brain systems and their modulation (e.g., by temporal neuronal synchronisation) as close correlates of behaviour and intermediate phenotypes from genes to behavioural variations. Especially, a systematic neurodynamic look at transitional processes from rest to stimulus-triggered goal-directed performance will aid behavioural understanding and guidance of children. Preliminary data suggest two separate oscillatory mechanisms in this respect. One is ongoing from pre- to post-stimulus processing and related to quantitative modification of behaviour, while another is merely related to qualitative effects of behaviour and reflects 'on-top' post-stimulus processing by temporal neuronal synchronisation of the oscillatory network in question. Suggested neurodynamic models may be tested in multilevel clinical experiments as well as in the framework of computational neuropsychiatry. PMID:19220591

  4. Postgraduate Educational Research on Violence, Gender, and HIV/AIDS in and around Schools (1995-2004)

    ERIC Educational Resources Information Center

    Moletsane, R.; Madiya, N.

    2011-01-01

    Social issues such as HIV/AIDS, bullying, and violence have recently come to the fore in schooling and related research in South Africa. This article describes and critically analyses Masters and Ph.D. research done in education in the period 1995-2004, with particular reference to the voice given to social issues, namely: gender, violence, and…

  5. Shaping the future of medical rehabilitation research: Using the interdisciplinary research model.

    PubMed

    Delisa, Joel A

    2004-04-01

    This memorial lecture addresses the fundamental requirements for developing a framework for interdisciplinary rehabilitation research. The needs for funding, clinical trials, staffing, education, and infrastructure are examined from the vantage points of my experiences as an educator, investigator, chief executive officer, department chair, and dean. Developing an academic base for the specialty of physical medicine and rehabilitation and demonstrating our expertise in rehabilitation research are fundamental to academic acceptance and will enhance our ability to compete for future funding for our investigations. PMID:15083427

  6. Computer Aided-Diagnosis of Prostate Cancer on Multiparametric MRI: A Technical Review of Current Research

    PubMed Central

    Turkbey, Baris; Choyke, Peter; Summers, Ronald M.

    2014-01-01

    Prostate cancer (PCa) is the most commonly diagnosed cancer among men in the United States. In this paper, we survey computer aided-diagnosis (CADx) systems that use multiparametric magnetic resonance imaging (MP-MRI) for detection and diagnosis of prostate cancer. We review and list mainstream techniques that are commonly utilized in image segmentation, registration, feature extraction, and classification. The performances of 15 state-of-the-art prostate CADx systems are compared through the area under their receiver operating characteristic curves (AUC). Challenges and potential directions to further the research of prostate CADx are discussed in this paper. Further improvements should be investigated to make prostate CADx systems useful in clinical practice. PMID:25525604

  7. Some Recent Advances and Future Directions in Permafrost Research

    NASA Astrophysics Data System (ADS)

    Romanovsky, V. E.; Grosse, G.; Marchenko, S. S.

    2010-12-01

    The impact of climate warming on permafrost and the potential of climate feedbacks resulting from permafrost thawing have recently received a great deal of attention. Field-based studies, remote sensing and modeling are revealing complex feedbacks of permafrost degradation to terrestrial and offshore environments in Polar Regions and the Earth’s atmosphere. Major research questions that remain to be adequately answered involve uncertainties about the vulnerability of permafrost to thaw, a projected decline in permafrost extent during the coming decades, ecosystem feedbacks, and the global consequences to climate change of mobilizing ancient carbon from permafrost as it thaws. Some of these important questions are: How resilient is permafrost to climate change and external disturbance, and what are the feedbacks to permafrost stability? How will permafrost degradation and landform changes alter hydrology and ecosystems? How large are carbon pools in and beneath permafrost including subsea permafrost, how vulnerable are they to disturbance related to degradation of permafrost, and to what extent will altered carbon and energy cycles affect the global climate? Ground temperatures are a primary indicator of permafrost stability. The monitoring network of the Thermal State of Permafrost (TSP) program under the Fourth International Polar Year (IPY) has more than 550 sites across the circumpolar region. TSP measurements, combined with numerical thermal modeling, now provide a relatively comprehensive assessment of panarctic permafrost dynamics during the last ~100 years. However, current numerical models project the future state of permafrost largely based on subsurface thermal dynamics driven by regional or global climate model projections and internal surface and ground properties. These models largely ignore complicated sub-grid scale feedbacks associated with dynamic ecological components and disturbance. Disturbances of the ground thermal regime can be triggered by

  8. Future of Research in Family Medicine: Where To From Here?

    PubMed Central

    Herbert, Carol P.

    2004-01-01

    Desired research outcomes in family medicine vary according to the developmental stage of the discipline and the context of practice. Several milestones in the evolution of family practice research worldwide have been achieved. Now family medicine researchers face the challenge of discovering how evidence-based primary health care can be delivered in a sustainable way to individuals within communities. To advance family medicine research, we must ensure that trainees have a positive research attitude, develop academic clinician-researchers, lobby for primary care research funding, support practitioners who wish to do research in their own practices, sustain practice-based research networks, and study important questions. PMID:15655092

  9. Computer-aided analysis at NASA Langley Research Center - Looking toward the 1990's

    NASA Technical Reports Server (NTRS)

    Petersen, Richard H.

    1985-01-01

    Aerospace research is inextricably intertwined with the programmable digital computer. Engineers and scientists at NASA Langley Research Center are requiring ever-increasing computing resources to carry out basic and applied research on problems and complex systems that would have been unthinkable Just ten years ago. The rapid changes in computer technology make planning for the future especially difficult, even five years in advance. In this paper, the evolution of computer resources and usage in research at Langley are briefly considered over the past thirty years, followed by a snapshot of the present. Finally, an extrapolation to the 1990's computer environment is made, with some thoughts on the tasks that engineers might face, and the background they will probably need.

  10. Research Universities and Scientific Misconduct: History, Policies, and the Future.

    ERIC Educational Resources Information Center

    Steneck, Nicholas H.

    1994-01-01

    The evolution of research misconduct policies in universities is traced since the late 1970s. It is argued that research universities have been slow to accept responsibility for research misconduct, and they are urged to examine their research environments and place more emphasis on research ethics education. (MSE)

  11. Mapping Interdisciplinary Fields: Efficiencies, Gaps and Redundancies in HIV/AIDS Research

    PubMed Central

    Adams, Jimi; Light, Ryan

    2014-01-01

    While interdisciplinarity continues to increase in popularity among funders and other scientific organizations, its potential to promote scientific advances remains under-examined. For HIV/AIDS research, we examine the dynamics of disciplinary integration (or lack thereof) providing insight into a field's knowledge base and those questions that remain unresolved. Drawing on the complete histories of two interdisciplinary journals, we construct bibliographic coupling networks based on overlapping citations to identify segregation into research clusters and estimate topic models of research content. We then compare how readily those bibliographic coupling clusters account for the structuring of topics covered within the field as it evolves over two decades. These comparisons challenge one-dimensional and/or cross-sectional approaches to interdisciplinarity. Some topics are increasingly coordinated across disciplinary boundaries (e.g., vaccine development); others remain relatively segmented into disconnected disciplinary domains for the full period (e.g., drug resistance). This divergence indicates heterogeneity in interdisciplinarity and emphasizes the need for critical approaches to studying the organization of science. PMID:25506703

  12. Mapping interdisciplinary fields: efficiencies, gaps and redundancies in HIV/AIDS research.

    PubMed

    Adams, Jimi; Light, Ryan

    2014-01-01

    While interdisciplinarity continues to increase in popularity among funders and other scientific organizations, its potential to promote scientific advances remains under-examined. For HIV/AIDS research, we examine the dynamics of disciplinary integration (or lack thereof) providing insight into a field's knowledge base and those questions that remain unresolved. Drawing on the complete histories of two interdisciplinary journals, we construct bibliographic coupling networks based on overlapping citations to identify segregation into research clusters and estimate topic models of research content. We then compare how readily those bibliographic coupling clusters account for the structuring of topics covered within the field as it evolves over two decades. These comparisons challenge one-dimensional and/or cross-sectional approaches to interdisciplinarity. Some topics are increasingly coordinated across disciplinary boundaries (e.g., vaccine development); others remain relatively segmented into disconnected disciplinary domains for the full period (e.g., drug resistance). This divergence indicates heterogeneity in interdisciplinarity and emphasizes the need for critical approaches to studying the organization of science. PMID:25506703

  13. Modeling course-based undergraduate research experiences: an agenda for future research and evaluation.

    PubMed

    Corwin, Lisa A; Graham, Mark J; Dolan, Erin L

    2015-03-01

    Course-based undergraduate research experiences (CUREs) are being championed as scalable ways of involving undergraduates in science research. Studies of CUREs have shown that participating students achieve many of the same outcomes as students who complete research internships. However, CUREs vary widely in their design and implementation, and aspects of CUREs that are necessary and sufficient to achieve desired student outcomes have not been elucidated. To guide future research aimed at understanding the causal mechanisms underlying CURE efficacy, we used a systems approach to generate pathway models representing hypotheses of how CURE outcomes are achieved. We started by reviewing studies of CUREs and research internships to generate a comprehensive set of outcomes of research experiences, determining the level of evidence supporting each outcome. We then used this body of research and drew from learning theory to hypothesize connections between what students do during CUREs and the outcomes that have the best empirical support. We offer these models as hypotheses for the CURE community to test, revise, elaborate, or refute. We also cite instruments that are ready to use in CURE assessment and note gaps for which instruments need to be developed. PMID:25687826

  14. Modeling Course-Based Undergraduate Research Experiences: An Agenda for Future Research and Evaluation

    PubMed Central

    Corwin, Lisa A.; Graham, Mark J.; Dolan, Erin L.

    2015-01-01

    Course-based undergraduate research experiences (CUREs) are being championed as scalable ways of involving undergraduates in science research. Studies of CUREs have shown that participating students achieve many of the same outcomes as students who complete research internships. However, CUREs vary widely in their design and implementation, and aspects of CUREs that are necessary and sufficient to achieve desired student outcomes have not been elucidated. To guide future research aimed at understanding the causal mechanisms underlying CURE efficacy, we used a systems approach to generate pathway models representing hypotheses of how CURE outcomes are achieved. We started by reviewing studies of CUREs and research internships to generate a comprehensive set of outcomes of research experiences, determining the level of evidence supporting each outcome. We then used this body of research and drew from learning theory to hypothesize connections between what students do during CUREs and the outcomes that have the best empirical support. We offer these models as hypotheses for the CURE community to test, revise, elaborate, or refute. We also cite instruments that are ready to use in CURE assessment and note gaps for which instruments need to be developed. PMID:25687826

  15. Qualitative Research in the Foreseeable Future: No Study Left Behind?

    ERIC Educational Resources Information Center

    Flinders, David J.

    2003-01-01

    Questions efficacy of Department of Education's recent decision to support only studies using quantitative experimental research designs. Describes advantages of qualitative research. (Contains 23 references.) (PKP)

  16. UAS Integration in the NAS Project and Future Autonomy Research

    NASA Technical Reports Server (NTRS)

    Johnson, Charles W.

    2014-01-01

    This presentation highlights NASA use of unmanned aircraft systems (UAS) and related technologies for civil purposes. This briefing will give more insight into the UAS projects progress and future goals.

  17. Using Futures Research Techniques in Strategic Planning: A Simulation.

    ERIC Educational Resources Information Center

    Morrison, James L.; Cope, Robert G.

    1985-01-01

    The ways in which a futures and strategic planning preconference workshop provided an environmental scan to identify a number of issues facing higher education are described. Exercises designed to rank and evaluate these issues are discussed. (MLW)

  18. Household Equipment Research: Past Accomplishments, Challenges for the Future.

    ERIC Educational Resources Information Center

    Lovingood, Rebecca P.; Lytton, Ruth H.

    1984-01-01

    Reviewing household equipment research over 75 years, this study found researchers responding to needs for information on new appliances, energy, and consumer protection. Since 1950 research has increasingly reflected marketers' concerns. Researchers have been hampered by problems of conceptualization, visibility, funding, and a reactive…

  19. The State of Mentoring Research: A Qualitative Review of Current Research Methods and Future Research Implications

    ERIC Educational Resources Information Center

    Allen, Tammy D.; Eby, Lillian T.; O'Brien, Kimberly E.; Lentz, Elizabeth

    2008-01-01

    Research regarding mentoring relationships has flourished during the past 20 years. This article reviews the methodology and content of 200 published mentoring articles. Some of the major concerns raised in this review include over reliance on cross-sectional designs and self-report data, a failure to differentiate between different forms of…

  20. The old problem of adherence: research on treatment adherence and its relevance for HIV/AIDS.

    PubMed

    Wright, M T

    2000-12-01

    The international published research on patient adherence was selectively reviewed with the goal of determining its relevance for the treatment of HIV/AIDS. Results show that not adhering to treatment regimes is so widespread that no combination of sociodemographic variables is reliably predictive of patients' not following doctors' orders. Achieving 100% adherence for any treatment or patient group does not appear to be realistic. Characteristics of the patient's situation, of the given therapy, and of the disease itself affect adherence. In addition, the patient-doctor relationship and the context of the treatment are important. Often overlooked are the existential dimensions of meaning, self-determination and quality of life which are particularly important for the chronically ill. Treatment needs to be negotiated individually with each patient on the basis of an open therapeutic relationship and with the help of multidimensional interventions. Lessons from the discourse on safer sex can steer adherence research and practice away from a behavioural and reductionist approach toward the context and meaning of treatment. PMID:11177448

  1. Protecting Human Research Subjects: The Past Defines the Future

    PubMed Central

    Breault, Joseph L.

    2006-01-01

    The creation of Institutional Review Boards to assure the protection of research subjects came out of terrible research abuses that resulted in the Belmont Report and federal regulations establishing rules for federally funded research and its independent review. The Common Rule became widely accepted as the way to oversee human research that is funded by federal agencies, or used in FDA submissions. The Office of Human Research Protections, now under the Secretary of DHHS, created Federalwide Assurances with groups that receive federal funding and others, the vast majority of which have agreed to apply the same ethical rules to all research regardless of funding source. There are controversies over the best methods to protect human research subjects, confusion about how to handle some of the gray areas, increased regulatory burdens, and debates about the adequacy of the IRB system. New exciting directions have evolved and overall, research subjects appear better protected than ever. PMID:21765779

  2. The AOA Dissertation Research Program: Resource for the Future

    ERIC Educational Resources Information Center

    Fritz, D.

    1978-01-01

    Discusses implications of the Dissertation Research Grant Program of the Department of Health, Education and Welfare's Administration on Aging for practitioners, career training institutions, the research community, and policymakers. Provides information about the program's administration, eligibility requirements, evaluation procedures, and…

  3. School-Based Performance Awards: Research Findings and Future Directions.

    ERIC Educational Resources Information Center

    Kelley, Carolyn; Heneman, Herbert, III; Milanowski, Anthony

    This paper synthesizes research on how motivation influenced teachers at two school-based performance award (SBPA) programs in Kentucky and in North Carolina. The research was conducted between 1995 and 1998 by the Consortium for Policy Research in Education. SBPA programs provide teachers and other school staff with pay bonuses for the…

  4. A Conceptual Framework for the Future of Successful Research Administration

    ERIC Educational Resources Information Center

    Lintz, Elizabeth M.

    2008-01-01

    Research administration has experienced dramatic changes over the past decades. As scientific research has evolved, higher education institutions have tried to adapt, with varying degrees of success. This paper presents a conceptual framework based on six cornerstones of research administration: mission, information, communication, collaboration,…

  5. AIDS/HIV education for preservice elementary teachers.

    PubMed

    Ballard, D J; White, D M; Glascoff, M A

    1990-08-01

    Professional preparation programs should provide future elementary teachers opportunities to develop competence in dealing with school-related AIDS issues. Curriculum writers and instructors of preservice elementary teachers could be more effective if they were aware of this groups' beliefs about school-related AIDS issues. A survey was conducted to assess the beliefs and opinions of preservice elementary teachers about school-related AIDS issues. Subjects (n = 157) generally agreed they would eventually have a child with AIDS in their classroom and agreed AIDS education should be included in the elementary grades, yet a substantial number did not believe they understood the basics about AIDS. Less than one-third indicated they knew how to clean up blood or body fluids safely. About one-third indicated they would feel personally threatened to teach a student with AIDS. These results are reflected in recommended AIDS educational content and resources for preservice elementary teachers and future research in this area. PMID:2232729

  6. Intel Teach to the Future[R] Leadership Forum: Formative Research. CCT Reports

    ERIC Educational Resources Information Center

    Pasnik, Shelley

    2004-01-01

    Consistent with the longitudinal evaluation of the Intel Teach to the Future Essentials Course that Education Development Center's Center for Children and Technology (CCT) has been conducting since the program's inception in 2000, the Intel Foundation commissioned CCT to conduct a formative evaluation of the Leadership Forum Pilot program. This…

  7. Energy and the Future: Research Priorities and National Policy

    ERIC Educational Resources Information Center

    Hammond, Allen L.

    1973-01-01

    Article provides an account of alternatives for solving energy shortage problems in future years. A national policy is needed. More concerted effort should be made to develop technologies for conversion of energy from conventional and non-conventional resources so that energy is cheaper, available for use and without environmental hazards. (PS)

  8. AIDS knowledge gaps: results from the first decade of the epidemic and implications for future public information efforts.

    PubMed

    Salmon, C T; Wooten, K; Gentry, E; Cole, G E; Kroger, F

    1996-01-01

    Throughout the first decade of AIDS, certain populations have been disproportionately affected by its spread, particularly men, blacks, Hispanics, and the young. Just as there are population differences in the spread of the disease, there are differences in knowledge about the disease as well. This article applies the knowledge gap framework to examine the nature and magnitude of gaps in knowledge among different populations. The analysis shows that persons of low education lag behind other groups in true-transmission knowledge (i.e., knowledge about ways in which HIV/AIDS actually is transmitted) and false-transmission knowledge (i.e., misconceptions about how the disease is spread). PMID:10947357

  9. Older Americans and AIDS: Transmission Risks and Primary Prevention Research Needs.

    ERIC Educational Resources Information Center

    Catania, Joseph A.; And Others

    1989-01-01

    Growing number of Acquired Immune Deficiency Syndrome (AIDS) cases among older Americans is of increasing concern. In context of primary prevention, reviews findings that bear on modes of human immunodeficiency virus (HIV) transmission (blood transfusions, sexual) among older individuals and knowledge of magnitude of the AIDS problem represented…

  10. Financial Aid: Who Needs It? MIS Research Profile, Volume One, Number 1, Mar. 1973.

    ERIC Educational Resources Information Center

    Jackson, Linda M.

    This report examines various aspects of financial aid including financial need as the basis for financial aid to students and the problem of inadequate funds. Recommendations suggest: (1) When forms are administered to the students, more guidance is needed to make them aware of the differences in the two systems presently serving the colleges and…

  11. Building Institutions to Serve Agriculture. A Summary Report of the CIC-AID Rural Development Research Project.

    ERIC Educational Resources Information Center

    Agency for International Development (Dept. of State), Washington, DC.

    To analyze the accomplishments under contracts between the Agency for International Development (AID) and U.S. land grant universities for technical assistance abroad in the development of educational and research institutions in agriculture and related fields, the Committee on Institutional Cooperation (CIC) collected data from the home campus of…

  12. A Survey of British Research in Audio-Visual Aids, Supplement No. 2, 1974. (Including Cumulative Index 1945-1974).

    ERIC Educational Resources Information Center

    Rodwell, Susie, Comp.

    The second supplement to the new (1972) edition of the Survey of Research in Audiovisual Aids carried out in Great Britain covers the year 1974. Ten separate sections cover the areas of projected media, non-projected media, sound media, radio, moving pictures, television, teaching machines and programed learning, computer-assisted instruction,…

  13. Stem Cell Research in Pakistan; Past, Present and Future

    PubMed Central

    Zahra, Sayeda Anum; Muzavir, Sayed Raheel; Ashraf, Sadia; Ahmad, Aftab

    2015-01-01

    Background and Objectives Stem cells have proved to have great therapeutic potential as stem cell treatment is replacing traditional ways of treatment in different disorders like cancer, aplastic anemia, stroke, heart disorders. The developed and developing countries are investing differently in this area of research so research output and clinical translation of research greatly vary among developed and developing countries. Present study was done to investigate the current status of stem cells research in Pakistan and ways to improve it. Results Many advanced countries (USA, UK and Canada etc.) are investing heavily in stem cell research and treatment. Different developing countries like Iran, Turkey and India are also following the developed countries and investing a lot in stem cells research. Pakistan is also making efforts in establishing this field to get desired benefits but unfortunately the progress is at very low pace. If Government plays an active role along with private sector, stem cell research in Pakistan can be boosted up. The numbers of publications from Pakistan are very less compared to developed and neighboring countries and Pakistan also has very less number of institutes working in this area of research. Conclusions Stem cells research is at its initial stages in Pakistan and there is great need to bring Government, academia and industry together so they could make serious efforts to promote research in this very important field. This will help millions of patients suffering from incurable disorders and will also reduce economic loss. PMID:26019749

  14. Future research on gender symmetry in physical assaults on partners.

    PubMed

    Straus, Murray A

    2006-11-01

    In the light of evidence from about 200 studies showing gender symmetry in perpetration of partner assault, research can now focus on why gender symmetry is predominant and on the implications of symmetry for primary prevention and treatment of partner violence. Progress in such research is handicapped by a number of problems: (1) Insufficient empirical research and a surplus of discussion and theory, (2) Blinders imposed by commitment to a single causal factor theory-patriarchy and male dominance-in the face of overwhelming evidence that this is only one of a multitude of causes, (3) Research purporting to investigate gender differences but which obtains data on only one gender, (4) Denial of research grants to projects that do not assume most partner violence is by male perpetrators, (5) Failure to investigate primary prevention and treatment programs for female offenders, and (6) Suppression of evidence on female perpetration by both researchers and agencies. PMID:17043370

  15. Inadvertent insertion of hearing aid impression material into the middle ear: Case report and implications for future community hearing services☆

    PubMed Central

    Algudkar, Ashwin; Maden, Belma; Singh, Arvind; Tatla, Taran

    2013-01-01

    INTRODUCTION The creation of ear moulds for hearing aids is generally considered a safe and routine procedure for trained professionals. In the literature there are reports of otological complications caused by hearing aid mould impression material in the middle ear cavity but such complications are considered rare. PRESENTATION OF CASE We present the case of a patient in whom impression material entered the middle ear through a perforation of the tympanic membrane during the process of making a hearing aid mould and review how this was managed. DISCUSSION We discuss how many aspects of the British Society of Audiology guidelines were not followed during this procedure and make recommendations as to how independent community practitioners need to be closely supervised with regular review to minimise the risks of such complications. CONCLUSION Our report demonstrates how a serious otological complication from the creation of a hearing aid impression in a community based private hearing clinic was managed. The reporting of such complications is rare but the incidence is likely to be much higher than the literature would suggest. We recommend and advise how these adverse incidents may be minimised and managed through competency reviews and formal referral links from community centres to hospital otolaryngology/audiology departments. PMID:24262374

  16. Research Models of the Future for Industrial and Organizational Psychology.

    ERIC Educational Resources Information Center

    Barrett, Gerald V.

    This paper presents three different aspects of research in industrial and organizational psychology. First, characteristics of major advances in science, and in the social and behavioral sciences are given, including: (1) team research is more common for major advances; and (2) young men under 35 are responsible for many major contributions.…

  17. The Future of Teaching Research in the Social Sciences

    ERIC Educational Resources Information Center

    Wagner, C.

    2009-01-01

    Current literature on teaching research methodology in the social sciences highlights the changing nature of our world in terms of its complexity and diversity, and points to how this affects the way in which we search for answers to related problems (Brew 2003, 3; Tashakkori and Teddlie 2003, 74). New ways of approaching research problems that…

  18. Constructing a Roadmap for Future Universal Screening Research beyond Academics

    ERIC Educational Resources Information Center

    Cook, Clayton R.; Volpe, Robert J.; Livanis, Andrew

    2010-01-01

    The majority of the literature on universal screening in education is devoted to academic screeners. However, research clearly indicates that other aspects of student functioning are closely associated with outcomes inside and outside of school. As a result, there are gaps in the current literature that call for additional research extending…

  19. Rater Cognition Research: Some Possible Directions for the Future

    ERIC Educational Resources Information Center

    Myford, Carol M.

    2012-01-01

    Over the last several decades, researchers have studied many and varied aspects of rater cognition. Those interested in pursuing basic research have focused on gaining an understanding of raters' thought processes as they score different types of performances and products, striving to understand how raters' mental representations and the cognitive…

  20. Uncertain Future for Education Research Despite Increased Congressional Support.

    ERIC Educational Resources Information Center

    Sroufe, Gerald E.

    1991-01-01

    The 101st Congress and the Administration have cooperated to provide a solid increase for education, research, and statistics for 1991, but a new deficit reduction measure prohibits increases for the next three years. Observes that appropriations committees now favor research and are unlikely to divert these funds. (DM)

  1. Research accomplishments and future goals in particle physics

    SciTech Connect

    Whitaker, J.S.

    1990-01-05

    This document presents our proposal to continue the activities of Boston University researchers in eight projects in high energy physics research: Colliding Beams Physics; Accelerator Design Physics; MACRO Project; Proton Decay Project; Theoretical Particle Physics; Muon G-2 Project; and Hadron Collider Physics. The scope of each of these projects is presented in detail in this paper.

  2. Reflections on Future Research in Adolescent Reproductive Health

    PubMed Central

    Gordon, Catherine M.; Loriaux, D. Lynn; Grumbach, Melvin M.; Rogol, Alan D.; Nelson, Lawrence M.

    2009-01-01

    A group of basic scientists, clinicians, clinical investigators, psychologists, patient advocacy groups, and representatives from professional societies and governmental agencies met at the National Institutes of Health in October, 2007 with the long-term goal of having the menstrual cycle accepted and understood as a marker of general health in adolescent girls. An equally important goal was to develop a research agenda for this area of investigation. This chapter comprises the highlights of discussions throughout that meeting, with an emphasis on ideas generated during a final session led by an internationally renowned physician-scientist, in which reports from four breakout groups were presented. The specific goal assigned to each group was to develop an agenda that would set the stage for how research should be conducted over the next 100 years, and to identify the pressing research questions that should be addressed related to the menstrual cycle and adolescent health. The four areas represented in discussion groups included: genetic research; metabolic and reproductive research; emotional health; and the promotion of conduct of clinical research. Insights are also provided by five clinical investigators, including two outside experts, on both topics of priority for a research agenda in the area of adolescent reproductive health, as well as how the research itself should be conducted. PMID:18574236

  3. Relationship Education Research: Current Status and Future Directions

    ERIC Educational Resources Information Center

    Markman, Howard J.; Rhoades, Galena K.

    2012-01-01

    The overarching aim of this article is to review the research on relationship education programs and approaches that has been published or accepted for publication since the last review article in 2003. This article provides a critical overview of the relationship education field and sets an agenda for research and practice for the next decade. A…

  4. The Research on School Marketing: Current Issues and Future Directions

    ERIC Educational Resources Information Center

    Oplatka, Izhar; Hemsley-Brown, Jane

    2004-01-01

    This review provides a synthesis of the scholarship that has sought to expand the understanding of educational marketing practice in schools. The following research questions guided this review. What are the common themes and characteristics that emerge from research about marketing in schools? What remains underdeveloped in the characterization…

  5. Economics of Education Research: A Review and Future Prospects

    ERIC Educational Resources Information Center

    Dearden, Lorraine; Machin, Stephen; Vignoles, Anna

    2009-01-01

    In this paper we offer an appraisal of the economics of education research area, charting its history as a field and discussing the ways in which economists have contributed both to education research and to education policy-making. In particular, we highlight the theoretical and methodological contributions that economists have made to the field…

  6. Future Directions in Community Power Research: A Colloquium.

    ERIC Educational Resources Information Center

    Wirt, Frederick M., Ed.

    This compilation of symposium papers on community power structure research focuses on the theme that community power structure research must shift away from case study methods and move toward aggregate data analysis. Advocating comparative analysis, seven authors present their views under the following topics: (1) Charles R. Adrian, "Several Loose…

  7. Race and racism in nursing research: past, present, and future.

    PubMed

    Porter, Cornelia P; Barbee, Evelyn

    2004-01-01

    Nursing research on race and racism began in the 1970s. However, because these concepts were seen as cultural attitudes, race and racism were obscured. The evidence on the presence of negative attitudes, biases, and stereotypes about different racial and ethnic groups is inconsistent. During the past two decades, research on race and racism has grown, but there is still an urgent need for more high-quality research on this subject. The major recommendations from this review are to conduct observational research on racism in clinical and practice settings, not as an intellectual end in itself; to assist in eliminating of the historically based disparities among members of racial and ethnic groups; and to conduct research about racism as it affects mobility in educational and practice settings. PMID:15368766

  8. Phenomenology and Mass Communication Research: An Uncertain Past and a Promising Future.

    ERIC Educational Resources Information Center

    Whitney, D. Charles; Barkin, Steve M.

    Future research on mass media and mass communication organizations might profitably emphasize phenomenological methods (phenomenology being an interpersonal, subjective reality construction as contrasted to an objective, rationalistic, institutional reality construction). Some major phenomenological concepts important to such research were…

  9. Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

    SciTech Connect

    Siemann, R.H.

    1997-01-01

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e{sup +}3{sup {minus}} linear colliders.

  10. The future of psychotherapy outcome research: science or political rhetoric?

    PubMed

    Peebles, J

    2000-11-01

    Although the relationship between research and clinical psychology has at times been conflicted, it has also been productive. Psychologists from both specialties have benefited from each others' work. The area of psychotherapy outcome research represents an important interface between the fields of clinical and research psychology. In an era of scarce resources and demands for accountability, there is pressure for researchers to justify the value of clinical practices. Recently, numerous articles have appeared recommending changes to the way psychotherapy research is conducted. The authors of these articles emphasize with urgency the importance of conducting and reporting research in a manner that will influence the decisions of policymakers and sanction funding for psychotherapy services. This article is an exploration of the impact of these recommendations, whose objective appears to be the promotion of psychological techniques for inclusion in clinical practice guidelines. It is argued that such recommendations may be in conflict with the philosophy and methods of science and may adversely affect public perception, perhaps leading psychologists to be seen as political lobbyists rather than clinicians and researchers. PMID:11092419

  11. Affordances of Augmented Reality in Science Learning: Suggestions for Future Research

    ERIC Educational Resources Information Center

    Cheng, Kun-Hung; Tsai, Chin-Chung

    2013-01-01

    Augmented reality (AR) is currently considered as having potential for pedagogical applications. However, in science education, research regarding AR-aided learning is in its infancy. To understand how AR could help science learning, this review paper firstly has identified two major approaches of utilizing AR technology in science education,…

  12. Open-Access Metabolomics Databases for Natural Product Research: Present Capabilities and Future Potential

    PubMed Central

    Johnson, Sean R.; Lange, Bernd Markus

    2015-01-01

    Various databases have been developed to aid in assigning structures to spectral peaks observed in metabolomics experiments. In this review article, we discuss the utility of currently available open-access spectral and chemical databases for natural products discovery. We also provide recommendations on how the research community can contribute to further improvements. PMID:25789275

  13. Nest predation research: Recent findings and future perspectives

    USGS Publications Warehouse

    Chalfoun, Anna L.; Ibanez-Alamo, J. D.; Magrath, R. D.; Schmidt, Kenneth A.; Thomson, R. L.; Oteyza, Juan C.; Haff, T. M.; Martin, T.E.

    2016-01-01

    Nest predation is a key source of selection for birds that has attracted increasing attention from ornithologists. The inclusion of new concepts applicable to nest predation that stem from social information, eavesdropping or physiology has expanded our knowledge considerably. Recent methodological advancements now allow focus on all three players within nest predation interactions: adults, offspring and predators. Indeed, the study of nest predation now forms a vital part of avian research in several fields, including animal behaviour, population ecology, evolution and conservation biology. However, within nest predation research there are important aspects that require further development, such as the comparison between ecological and evolutionary antipredator responses, and the role of anthropogenic change. We hope this review of recent findings and the presentation of new research avenues will encourage researchers to study this important and interesting selective pressure, and ultimately will help us to better understand the biology of birds.

  14. The future of intersite networking. [Office of Energy Research

    SciTech Connect

    Not Available

    1986-11-01

    Copies of viewgraphs and summaries of three discussion groups are presented. The purpose of the workshop was to identify strategies for meeting the computer networking needs to the scientists under the Office of Energy Research. (WRF)

  15. Future Directions in Rotorcraft Technology at Ames Research Center

    NASA Technical Reports Server (NTRS)

    Aiken, Edwin W.; Ormiston, Robert A; Young, Larry A.

    2000-01-01

    Members of the NASA and Army rotorcraft research community at Ames Research Center have developed a vision for 'Vertical Flight 2025'. This paper describes the development of that vision and the steps being taken to implement it. In an effort to realize the vision, consistent with both NASA and Army Aviation strategic plans, two specific technology development projects have been identified: (1) one focused on a personal transportation system capable of vertical flight (the 'Roto-Mobile') and (2) the other on small autonomous rotorcraft (which is inclusive of vehicles which range in grams of gross weight for 'MicroRotorcraft' to thousands of kilograms for rotorcraft uninhabited aerial vehicles). The paper provides a status report on these projects as well as a summary of other revolutionary research thrusts being planned and executed at Ames Research Center.

  16. Research accomplishments and future goals in particle physics

    SciTech Connect

    Not Available

    1990-11-30

    This document presents our proposal to continue the activities of Boston University researchers in high energy physics research. We have a broad program of participation in both non-accelerator and accelerator-based efforts. High energy research at Boston University has a special focus on the physics program of the Superconducting Supercollider. We are active in research and development for detector subsystems, in the design of experiments, and in study of the phenomenology of the very high energy interactions to be observed at the SSC. The particular areas discussed in this paper are: colliding beams physics; accelerator design physics; MACRO project; proton decay project; theoretical particle physics; muon G-2 project; fast liquid scintillators; SSCINTCAL project; TRD project; massively parallel processing for the SSC; and physics analysis and vertex detector upgrade at L3.

  17. International Arctic Research Collaborations: Past, Present and Future

    NASA Astrophysics Data System (ADS)

    Kintisch, E. S.

    2015-12-01

    International cooperation on Arctic research has a long and storied history, predating even the first International Polar Year in 1881. But scientists want to improve and expand current efforts to conduct international Arctic research, despite politcal and legal barriers that can hamper it. A review of the past and present aspects of such research can inform that effort. As part of a six month fellowship at the Center for Science Diplomacy at the American Association for the Advancement of Science I studied the history and current status of international cooperation in the Arctic. I will report on my findings, which include the fact that some of the first substantial international environmental research and regulatory cooperation began in the far North. My session will identify the elements that make international research collaborations successful, for example more than a century of cooperative work by Russian and Norwegian fishery scientists to monitor and regulate the cod trade in the Barents Sea. And it will explore the challenges that can threaten such collaborations. These can include rules that stymie data collection, block the import of certain analytical equipment across national boundaries, and bar the export of soil or water samples. I will mention specific complications to recent international arctic research projects. These include the SWERUS cruise, a joint effort between Sweden, Russia and the US, an effort to study carbon fluxes over the East Siberian Arctic Shelf in 2014. The session will also review progress towards a new international agreeement, first proposed by the US, on improving arctic research cooperation. That deal is focused on removing the bureacratic and legal barriers to scientists seeking to conduct arctic research on foreign waters and land.

  18. Polar Research Board annual report, 1987 and future plans

    SciTech Connect

    Not Available

    1988-01-01

    This annual report describes the Polar Research Board, its origin and objectives, its work and plans, and its principle activities and accomplishments during calendar year 1987. The Overview presents a concise summary of the various aspects of the Board's program and of its responsibilities as US National Committee for the Scientific Committee on Antarctic Research (SCAR) of the International Council of Scientific Unins. Arctic and Antarctic activities are described.

  19. Polar Research Board annual report, 1987 and future plans

    SciTech Connect

    Not Available

    1988-12-31

    This annual report describes the Polar Research Board, its origin and objectives, its work and plans, and its principle activities and accomplishments during calendar year 1987. The Overview presents a concise summary of the various aspects of the Board`s program and of its responsibilities as US National Committee for the Scientific Committee on Antarctic Research (SCAR) of the International Council of Scientific Unins. Arctic and Antarctic activities are described.

  20. Imagine! On the Future of Teaching and Learning and the Academic Research Library

    ERIC Educational Resources Information Center

    Miller, Kelly E.

    2014-01-01

    In the future, what role will the academic research library play in achieving the mission of higher education? This essay describes seven strategies that academic research libraries can adopt to become future-present libraries--libraries that foster what Douglas Thomas and John Seely Brown have called "a new culture of learning." Written…

  1. Current state of the art, multimodality research and future visions for the treatment of patients with prostate cancer: consensus results from "Challenges and Chances in Prostate Cancer Research Meeting 2013".

    PubMed

    Combs, Stephanie E; Debus, Jürgen; Feick, Günter; Hadaschik, Boris; Hohenfellner, Markus; Schüle, Roland; Zacharias, Jens-Peter; Schwardt, Malte

    2014-01-01

    A brainstorming and consensus meeting organized by the German Cancer Aid focused on modern treatment of prostate cancer and promising innovative techniques and research areas. Besides optimization of screening algorithms, molecular-based stratification and individually tailored treatment regimens will be the future of multimodal prostate cancer management. Effective interdisciplinary structures, including biobanking and data collection mechanisms are the basis for such developments. PMID:25381175

  2. Saliva proteome research: current status and future outlook.

    PubMed

    Schulz, Benjamin L; Cooper-White, Justin; Punyadeera, Chamindie K

    2013-09-01

    Human saliva harbours proteins of clinical relevance and about 30% of blood proteins are also present in saliva. This highlights that saliva can be used for clinical applications just as urine or blood. However, the translation of salivary biomarker discoveries into clinical settings is hampered by the dynamics and complexity of the salivary proteome. This review focuses on the current status of technological developments and achievements relating to approaches for unravelling the human salivary proteome. We discuss the dynamics of the salivary proteome, as well as the importance of sample preparation and processing techniques and their influence on downstream protein applications; post-translational modifications of salivary proteome and protein: protein interactions. In addition, we describe possible enrichment strategies for discerning post-translational modifications of salivary proteins, the potential utility of selected-reaction-monitoring techniques for biomarker discovery and validation, limitations to proteomics and the biomarker challenge and future perspectives. In summary, we provide recommendations for practical saliva sampling, processing and storage conditions to increase the quality of future studies in an emerging field of saliva clinical proteomics. We propose that the advent of technologies allowing sensitive and high throughput proteome-wide analyses, coupled to well-controlled study design, will allow saliva to enter clinical practice as an alternative to blood-based methods due to its simplistic nature of sampling, non-invasiveness, easy of collection and multiple collections by untrained professionals and cost-effective advantages. PMID:22612344

  3. Intergovernmental Aid for Cities and Schools: A Comment on Research Methods.

    ERIC Educational Resources Information Center

    Pelissero, John P.; Morgan, David R.

    1987-01-01

    Explores alternative means of studying the responsiveness of states to the pressing financial needs of cities and schools. Suggests ways to better understand intergovernmental aid allocations that are population-driven. (BSR)

  4. Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS.

    PubMed

    Tappuni, A R; Shiboski, C

    2016-04-01

    The Research Agenda generated by the 7th World Workshop on Oral Health and Disease in AIDS (WW7) is delivered in this paper. Panels of international experts presided over nine workshops that constituted the conference held in November 2014 in Hyderabad, India. The main goal of the Workshop was to bring together clinician and scientists interested in the subject to debate with world-wide perspectives current issues related to the oral manifestations in HIV/AIDS. The workshops were structured around three themes; basic science, clinical/translational science and social science and were attended by 135 participants from 31 countries. The research questions debated at the workshops are presented in nine consensus papers published in this issue and are summarised in this paper along with an outline of the identified research needs in the field. PMID:27109289

  5. Complex plasma research on ISS past, present, and future facilities

    NASA Astrophysics Data System (ADS)

    Seurig, R.; Morfill, G.; Fortov, V.; Hofmann, P.

    2007-11-01

    The research in dusty plasma, also known as complex plasma, under prolonged microgravity condition took its first steps in 1998 onboard the Russian Space Station MIR: cosmonauts Vladimir Solovyov and Pavel Vinogradov conducted the first experiments to obtain plasma-dust crystals in the 'Plazmennyi Kristall 1'(PK-1) device using the sun as a 'natural' ionization source. This experiment was followed afterwards by the PK-2 already utilizing its own DC plasma generator. A major step came only three years later with the PKE-Nefedov facility (formerly called PKE-3). Launched in February 2001 and operated in over 13 missions for five consecutive years in the Russian Segment of the International Space Station ISS, this bilateral German-Russian research facility has already shown some surprising, new behavior of radio-frequency induced complex plasmas. An advanced model of PKE-Nefedov, the PK-3 Plus experiment apparatus, is getting readied to be launched to ISS on Progress Cargo spacecraft 20P. Additional developments are in progress to continue this exciting growing research field with: (a) PK-4 utilizing high voltage DC controlled plasma, and (b) IMPACT Laboratory, the European Space Agency's next generation premier research laboratory for plasma and dust physics on the ISS. The paper will provide background information of each of the complex plasma research facilities.

  6. Accounting for context: future directions in bioethics theory and research.

    PubMed

    Douglas-Steele, D; Hundert, E M

    1996-06-01

    Many physicians have found that the traditional approach to bioethics fails to account for important aspects of their moral experience in practice. New approaches to bioethics theory are challenging the traditional application of universal moral principles based in liberal moral theory. At the same time, a shift in both the goals and methods of bioethics education has accompanied its "coming of age" in the medical school curriculum. Taken together, these changes challenge both bioethics educators and theorists to come closer to the details and nuances of real clinical encounters. The emerging trend emphasizes the importance of context in bioethics education and in the moral theory and research undergirding it. This article introduces one research approach examining the practical life contexts of medical students' ethical experiences and learning. It calls for increased attention to research and theory in bioethics that more adequately accounts for the ways different contexts produce significant changes in meaning and understanding in medical encounters. PMID:8767639

  7. Contemporary issues and future directions for research into pathological gambling.

    PubMed

    Dickerson, M; Baron, E

    2000-08-01

    The recent healthy increase in research into all aspects of gambling is noted. The dominant theme accounting for most of this research is the mental disorder model of pathological gambling and measures that have been derived from this conceptualization. It is suggested that an alternative approach focusing on the construct of choice or subjective control over gambling may be a research direction that will ensure that progress is maintained. In this paper a context for the discussion is provided by first identifying briefly fundamental conceptual and methodological issues associated with the mental disorder model. In particular it is argued that the heterogeneity of the diagnosis of pathological gambling makes the research task of assessing truly independent variables extremely difficult. Subsequently an illustrative schema is presented that demonstrates both the potential advantages and some of the complexities associated with the dependent variable of self-control over gambling behaviour. The main advantages are argued to be (a) the focus of research is narrowed to one potential cause of harmful impacts rather than the great diversity of impacts themselves, (b) prospective studies of regular gamblers in real gambling venues may be a key source of insight into the development of pathological gambling and (c) it promotes the development of theoretical links with the mainstream of the discipline of psychology. Despite the conceptual difficulties that may be associated with the variable of self-control, it is suggested that these may be overcome because contemporary research into the addictive behaviours has demonstrated considerable success in the definition and measurement of control and related themes such as craving, restraint and temptation. PMID:11092063

  8. Behavioral Intervention Technologies: Evidence review and recommendations for future research

    PubMed Central

    Mohr, David C.; Burns, Michelle Nicole; Schueller, Stephen M.; Clarke, Gregory; Klinkman, Michael

    2013-01-01

    This paper reports on the findings of a technical expert panel convened by the Agency for Healthcare Research and Quality and the National Institute of Mental Health, charged with reviewing the state of research on behavioral intervention technologies (BITs) in mental health and identifying the top research priorities. BITs is the comprehensive term used to refer to behavioral and psychological interventions that use information and communication technology features to address behavioral and mental health outcomes. Mental health BITs using videoconferencing and standard telephone technologies to deliver psychotherapy have been wellvalidated. Web-based interventions have shown efficacy across a broad range of mental health outcomes, although outcomes vary widely. Social media such as online support groups have produced generally disappointing outcomes when used alone. Mobile technologies have received limited attention for mental health outcomes, although findings from behavioral health suggest they are promising. Virtual reality has shown good efficacy for anxiety and pediatric disorders. Serious gaming has received relatively little work in mental health. Recommendations for next step research in each of these are made. Research focused on understanding of reach, adherence, barriers and cost is recommended. As BITs can generate large amounts of data, improvements in the collection, storage, analysis, and visualization of big data will be required. Traditional psychological and behavioral theories have proven insufficient to understand how BITs produce behavioral change. Thus new theoretical models, as well as new evaluation strategies, will be required. Finally, for BITs to have a public health impact, research on implementation and application to prevention will be required. PMID:23664503

  9. Biological underpinnings of psychogenic nonepileptic seizures: directions for future research.

    PubMed

    Asadi-Pooya, Ali A

    2016-07-01

    Psychogenic nonepileptic seizures (PNES) are relatively common occurrences in epilepsy centers, but their pathophysiology is still poorly understood. Research that elucidates the pathophysiology of PNES, including their neurobiological basis and biomarkers, may have important clinical implications. The literature provides some evidence that genetic factors, intrinsic factors, and environmental factors probably play a significant role as the biological underpinnings of PNES. Researchers may be able to learn more about the pathophysiology of PNES by investigating the effects of each of these factors on functional and structural brain connectivity. PMID:26956567

  10. DOE Automotive Composite Materials Research: Present and Future Efforts

    SciTech Connect

    Warren, C.D.

    1999-08-10

    One method of increasing automotive energy efficiency is through mass reduction of structural components by the incorporation of composite materials. Significant use of glass reinforced polymers as structural components could yield a 20--30% reduction in vehicle weight while the use of carbon fiber reinforced materials could yield a 40--60% reduction in mass. Specific areas of research for lightweighting automotive components are listed, along with research needs for each of these categories: (1) low mass metals; (2) polymer composites; and (3) ceramic materials.

  11. The present and future role of microfluidics in biomedical research

    NASA Astrophysics Data System (ADS)

    Sackmann, Eric K.; Fulton, Anna L.; Beebe, David J.

    2014-03-01

    Microfluidics, a technology characterized by the engineered manipulation of fluids at the submillimetre scale, has shown considerable promise for improving diagnostics and biology research. Certain properties of microfluidic technologies, such as rapid sample processing and the precise control of fluids in an assay, have made them attractive candidates to replace traditional experimental approaches. Here we analyse the progress made by lab-on-a-chip microtechnologies in recent years, and discuss the clinical and research areas in which they have made the greatest impact. We also suggest directions that biologists, engineers and clinicians can take to help this technology live up to its potential.

  12. NIOSH research initiatives to prevent back injuries to nursing assistants, aides, and orderlies in nursing homes.

    PubMed

    Collins, J W; Owen, B D

    1996-04-01

    Over the past 100 years, advances in nutrition, modern medicine, public health, and a multitude of public health improvements have increased the life expectancy of U.S. residents. The fact that Americans are living longer has resulted in extensive growth in our elderly population and a rapid employment growth that delivered about 2 million new jobs between 1980 and 1989 in the health care workforce. The Bureau of Labor Statistics Injury and Illness Data for nursing homes rose from 10.7 to 18.6 injuries or illnesses per 100 full-time workers between 1980 and 1992. The injury and illness rates among nursing home workers are partly due to the physical stress of providing round-the-clock assistance with the basic activities of daily living, such as getting in and out of a bed or chair, as well as bathing and toileting. The National Institute for Occupational Safety and Health (NIOSH) is conducting a series of research studies to identify strategies to reduce the risk of musculoskeletal injuries to workers in nursing homes. NIOSH has funded two laboratory evaluations of resident transferring methods and one field study in an actual nursing home. The purpose of this paper is to describe the key findings from past NIOSH research initiatives and to present an overview of future research. PMID:8728153

  13. Future Directions for Fusion Propulsion Research at NASA

    NASA Technical Reports Server (NTRS)

    Adams, Robert B.; Cassibry, Jason T.

    2005-01-01

    Fusion propulsion is inevitable if the human race remains dedicated to exploration of the solar system. There are fundamental reasons why fusion surpasses more traditional approaches to routine crewed missions to Mars, crewed missions to the outer planets, and deep space high speed robotic missions, assuming that reduced trip times, increased payloads, and higher available power are desired. A recent series of informal discussions were held among members from government, academia, and industry concerning fusion propulsion. We compiled a sufficient set of arguments for utilizing fusion in space. .If the U.S. is to lead the effort and produce a working system in a reasonable amount of time, NASA must take the initiative, relying on, but not waiting for, DOE guidance. Arguments for fusion propulsion are presented, along with fusion enabled mission examples, fusion technology trade space, and a proposed outline for future efforts.

  14. Perceived Value of Research Preparation Opportunities for Future Music Education Professors

    ERIC Educational Resources Information Center

    Rohwer, Debbie; Svec, Christina

    2014-01-01

    The purpose of the study was to describe research leaders' perceptions of the relative importance of various research preparation opportunities for future music education professors. The 122 questionnaire respondents answered 38 Likert-type and open-ended content questions that asked about research experiences, research skills, research…

  15. Future challenges for nuclear data research in fission (u)

    SciTech Connect

    Chadwick, Mark B

    2010-01-01

    I describe some high priority research areas in nuclear fission, where applications in nuclear reactor technologies and in modeling criticality in general are demanding higher accuracies in our databases. We focus on fission cross sections, fission neutron spectra, and fission product data.

  16. Priorities in pediatric epilepsy research: improving children's futures today.

    PubMed

    Berg, Anne T; Baca, Christine B; Loddenkemper, Tobias; Vickrey, Barbara G; Dlugos, Dennis

    2013-09-24

    The Priorities in Pediatric Epilepsy Research workshop was held in the spirit of patient-centered and patient-driven mandates for developing best practices in care, particularly for epilepsy beginning under age 3 years. The workshop brought together parents, representatives of voluntary advocacy organizations, physicians, allied health professionals, researchers, and administrators to identify priority areas for pediatric epilepsy care and research including implementation and testing of interventions designed to improve care processes and outcomes. Priorities highlighted were 1) patient outcomes, especially seizure control but also behavioral, academic, and social functioning; 2) early and accurate diagnosis and optimal treatment; 3) role and involvement of parents (communication and shared decision-making); and 4) integration of school and community organizations with epilepsy care delivery. Key factors influencing pediatric epilepsy care included the child's impairments and seizure presentation, parents, providers, the health care system, and community systems. Care was represented as a sequential process from initial onset of seizures to referral for comprehensive evaluation when needed. We considered an alternative model in which comprehensive care would be utilized from onset, proactively, rather than reactively after pharmacoresistance became obvious. Barriers, including limited levels of evidence about many aspects of diagnosis and management, access to care--particularly epilepsy specialty and behavioral health care--and implementation, were identified. Progress hinges on coordinated research efforts that systematically address gaps in knowledge and overcoming barriers to access and implementation. The stakes are considerable, and the potential benefits for reduced burden of refractory epilepsy and lifelong disabilities may be enormous. PMID:23966254

  17. Research on Community Bands: Past, Present, and Future

    ERIC Educational Resources Information Center

    Rohwer, Debbie

    2016-01-01

    The purpose of this review of literature was to synthesize findings of studies investigating community bands. This review of literature centers on research that has been conducted on community bands in status studies, historical/cultural studies, pedagogical studies, health and wellness studies, and intergenerational studies. The last section of…

  18. Reconciling (Seemingly) Discrepant Findings: Implications for Practice and Future Research

    ERIC Educational Resources Information Center

    Bowman, Nicholas A.; Herzog, Serge

    2011-01-01

    Decades of research in survey methodology and psychology have yielded important insights about how to create effective and valid survey instruments. As Porter (in press) has argued convincingly, college student surveys often fall well short of these standards by placing unrealistic demands on students' memory and by assuming that students readily…

  19. Building Futures: The Head Start Impact Study. Research Design Plan.

    ERIC Educational Resources Information Center

    Puma, Michael; Bell, Stephen; Shapiro, Gary; Broene, Pam; Cook, Ronna; Friedman, Janet; Heid, Camilla

    Along with the rapid expansion over the past decade of Head Start, a program providing comprehensive early childhood development services to low-income children, their families, and their communities, has come the demand for rigorous research to demonstrate program effectiveness. This report describes the proposed design of a national study of the…

  20. Studying Science Teacher Identity: Current Insights and Future Research Directions

    ERIC Educational Resources Information Center

    Avraamidou, Lucy

    2014-01-01

    Over the past 10?years an increasing number of articles have been published in leading science education journals that report on research about teacher identity and describe interventions that support teacher identity development. My purpose in this review paper is to examine how the construct of science teacher identity has been conceptualised…

  1. Exploring the Future of Lifelong Learning: Advocacy, Research and Footprinting

    ERIC Educational Resources Information Center

    Chisholm, Lynne

    2013-01-01

    This reflective think-tank contribution begins by comparing advocacy and research as distinct modalities of professional and social action. In practice they frequently elide and merge into one another. While alliance and complementarity between the two modalities is constructive for shaping policy and practice, it poses risks when governments and…

  2. Multilingualism in Australia: Reflections on Current and Future Research Trends

    ERIC Educational Resources Information Center

    Rubino, Antonia

    2010-01-01

    This paper gives a critical overview of Australian research in the area of immigrant languages, arguing that this field of study is a significant component of the wider applied linguistics scene in Australia and has also contributed to enhancing the broad appreciation of the cultural and linguistic diversity of the country. It shows that research…

  3. BIO2010: Transforming Undergraduate Education for Future Research Biologists

    ERIC Educational Resources Information Center

    National Academies Press, 2003

    2003-01-01

    The report discusses incorporating more math, physics, chemistry, engineering and computer science into classes and laboratory work and emphasizing independent research will help undergraduate education reflect real-world science. Schools, professional societies and funding agencies should develop new teaching materials and facilitate faculty…

  4. Making Numbers Matter: Present and Future Research in Risk Communication

    ERIC Educational Resources Information Center

    Fagerlin, Angela; Ubel, Peter A.; Smith, Dylan M.; Zikmund-Fisher, Brian J.

    2007-01-01

    Objective: To summarize existing research on individual numeracy and methods for presenting risk information to patients. Methods: We selectively retrieved articles from MEDLINE and the "Social Sciences Citation Index". Results: Many Americans have low numeracy skills, a deficit that impedes effective health care. Approaches to risk communication…

  5. Identifying Future Scientists: Predicting Persistence into Research Training

    ERIC Educational Resources Information Center

    McGee, Richard; Keller, Jill L.

    2007-01-01

    This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end,…

  6. Psychological Issues in Cancer Genetics: Current Research and Future Priorities.

    ERIC Educational Resources Information Center

    Hopwood, Penelope

    1997-01-01

    Data concerning the psychological impact of high risk of cancer are reviewed, including implications of genetic testing, breast screening,and accuracy of women's risk estimates. Work in progress on prophylactic mastectomy and chemoprevention is reviewed. Research on cancer families, and interventions and prevention strategies for high-risk…

  7. Future Directions for NCI’s Surveillance Research Program

    Cancer.gov

    Since the early 1970s, NCI’s SEER program has been an invaluable resource for statistics on cancer in the United States. For the past several years, SEER researchers have been working toward a much broader and comprehensive goal for providing cancer stati

  8. Gifted Male Readers: Current Understandings and Suggestions for Future Research

    ERIC Educational Resources Information Center

    Pagnani, Alexander R.

    2013-01-01

    Research literature concerning gifted male readers relies primarily on more extensive bodies of work regarding gifted males and male readers. Studied as a whole, the two halves portray a worrisome state of affairs for gifted male readers, who lag behind their female counterparts in the same patterns found across the ability spectrum. This literacy…

  9. Creating the Future: "New Directions" in American Research Universities

    ERIC Educational Resources Information Center

    Brint, Steven

    2005-01-01

    This paper assesses the causes and consequences of recent American efforts to configure the research university as an engine of economic and social change. Drawing upon interviews and strategic plans, the paper describes recent policies to encourage "interdisciplinary creativity," in a context of increasing income from private gifts and endowments.

  10. Women in Management: Leadership Theories, Research Results, and Future Directions.

    ERIC Educational Resources Information Center

    Putnam, Linda L.

    This review of the literature about women in management advocates the pursuit of research on women executives as unique components in the organizational setting, with the warning that careful and unremitting attention be paid to the selection of theoretical perspectives. It examines trait and role theory, and discusses such factors as…

  11. A Critical Look at Communication Strategies: Possibilities for Future Research

    ERIC Educational Resources Information Center

    Doqaruni, Vahid Rahmani

    2015-01-01

    Like general theories of human communication, previous research into second language (L2) communication strategies (CSs) has also been characterized on either interactional conceived account or cognitively conceived one. However, this paper is a critical attempt to show that CSs' full significance can only be understood if the domain of CSs…

  12. The age of citizen science: Stimulating future environmental research

    NASA Astrophysics Data System (ADS)

    Burgess, S. N.

    2010-12-01

    Public awareness of the state of the ocean is growing with issues such as climate change, over-harvesting, marine pollution, coral bleaching, ocean acidification and sea level rise appearing regularly in popular media outlets. Society is also placing greater value on the range of ecosystem services the ocean provides. This increased consciousness of environmental change due to a combination of anthropogenic activities and impacts from climate change offers scientists the opportunity of engaging citizens in environmental research. The term citizen science refers to scientific research carried out by citizens and led by professionals, which involves large scale data collection whilst simultaneously engaging and educating those who participate. Most projects that engage citizen scientists have been specifically designed to provide an educational benefit to the volunteer and benefit the scientific inquiry by collecting extensive data sets over large geographical areas. Engaging the public in environmental science is not a new concept and successful projects (such as the Audobon Christmas Bird Count and Earthwatch) have been running for several decades resulting in hundreds of thousands of people conducting long-term field research in partnership with scientists based at universities worldwide. The realm of citizen science projects is continually expanding, with public engagement options ranging from science online; to backyard afternoon studies; to fully immersive experiential learning projects running for weeks at a time. Some organisations, such as Earthwatch also work in partnership with private industry; giving scientists access to more funding opportunities than those avenues traditionally available. These scientist -industry partnerships provide mutual benefits as the results of research projects in environments such as coastal ecosystems feed directly back into business risk strategies; for example mitigating shoreline erosion, storm surges, over fishing and

  13. Support for international agricultural research: current status and future challenges.

    PubMed

    Zeigler, Robert S; Mohanty, Samarendu

    2010-11-30

    The success of the first Green Revolution in the form of abundant food supplies and low prices over the past two decades has diverted the world's attention from agriculture to other pressing issues. This has resulted in lower support for the agricultural research work primarily undertaken by the 15 research centers of the Consultative Group on International Agricultural Research (CGIAR). The total support in real dollars for most of the last three decades has been more or less flat although the number of centers increased from 4 to 15. However, since 2000, the funding situation has improved for the CGIAR centers, with almost all the increase coming from grants earmarked for specific research projects. Even for some centers such as the International Rice Research Institute (IRRI), the downward trend continued as late as 2006 with the budget in real dollars reaching the 1978 level of support. The recent food crisis has renewed the call for a second Green Revolution by revitalizing yield growth to feed the world in the face of growing population and a shrinking land base for agricultural use. The slowdown in yield growth because of decades of neglect in agricultural research and infrastructure development has been identified as the underlying reason for the recent food crisis. For the second Green Revolution to be successful, the CGIAR centers will have to play a complex role by expanding productivity in a sustainable manner with fewer resources. Thus, it is crucial to examine the current structure of support for the CGIAR centers and identify the challenges ahead in terms of source and end use of funds for the success of the second Green Revolution. The objective of this paper is to provide a historical perspective on the support to the CGIAR centers and to examine the current status of funding, in particular, the role of project-specific grants in rebuilding capacity of these centers. The paper will also discuss the nature of the support (unrestricted vs. project

  14. Community-Based Participatory Clinical Research in Obesity by Adolescents: Pipeline for Researchers of the Future

    PubMed Central

    Branch, Robert; Chester, Ann

    2015-01-01

    We propose a novel, untapped opportunity, challenging cultural and man-power barriers to transferring advances in biomedical science knowledge that will improve community health care (Type II Clinical Translational Research) in a medically underserved community. We describe a pilot model in which adolescents apply principles of Community-Based Participatory Research (CBPR) at the epicenter of the obesity diabetes epidemic in rural Appalachia in West Virginia. The model invites minority, financially disadvantaged, and educationally disadvantaged adolescents to become educated on ethics, then provides infrastructure to support study design and conduct of CBPR. This experience demonstrates that these adolescents can efficiently, with quality and integrity, reach into the most vulnerable of communities and their own families to show that the prevalence of obesity is at 50% and diabetes 10.4% (n = 989). Our experience illustrates the infrastructure requirements for this strategy to be successful and emphasizes the substantial benefit that could accrue if the model is successfully sustained. The benefit includes not only the translation of knowledge to influence community lifestyle behavior but also the creation of a pipeline of new biomedical scientists for the future. PMID:20443918

  15. Current and Future Research in Active Control of Lightweight, Flexible Structures Using the X-56 Aircraft

    NASA Technical Reports Server (NTRS)

    Ryan, John J.; Bosworth, John T.; Burken, John J.; Suh, Peter M.

    2014-01-01

    The X-56 Multi-Utility Technology Testbed aircraft system is a versatile experimental research flight platform. The system was primarily designed to investigate active control of lightweight flexible structures, but is reconfigurable and capable of hosting a wide breadth of research. Current research includes flight experimentation of a Lockheed Martin designed active control flutter suppression system. Future research plans continue experimentation with alternative control systems, explore the use of novel sensor systems, and experiments with the use of novel control effectors. This paper describes the aircraft system, current research efforts designed around the system, and future planned research efforts that will be hosted on the aircraft system.

  16. Solar-terrestrial research opportunities - A look to the future

    NASA Technical Reports Server (NTRS)

    Intriligator, D. S.

    1984-01-01

    Recent and proposed research programs and their impact on the understanding of solar-terrestrial interactions, the processes driving solar activity, and the propagation of the solar wind are outlined. The magnetospheres of the earth and major planets have been mapped and their interactions with the solar wind modeled. MHD activity has been identified as the driving force for stellar surface activity, and Pioneer data are permitting a mapping of the outer areas of the heliosphere. Further studies are required to understand solar magnetic field-earth magnetosphere, ionosphere-atmosphere interactions, the effects of solar heating on earth atmosphere ozone levels, and the effects of solar transient events on the earth atmosphere. The initiation of an International Geosphere-Biosphere Program is now under study and several satellites for solar-terrestrial research are under development as cooperative efforts among the U.S., Japanese, and European agencies.

  17. The future radioactive ion beam research program at Oak Ridge

    NASA Astrophysics Data System (ADS)

    Ball, James B.

    1994-03-01

    Early in 1995, the ORNL Holifield Facility is scheduled to return to operation as a dedicated radioactive ion beam (RIB) facility. This enhanced capability will open up new possibilities for research on the structure of and phenomena occurring in proton-rich nuclei. Among the opportunities will be the creation of heavier N≈Z nuclei, approaching 100Sn, and the study of exotic nuclear shapes, extensions of studies of the p-n interaction and super-allowed beta decay, and examination of nuclear structure near the proton drip line. In addition to new nuclear and atomic physics research opportunities, the beams from the Holifield RIB facility are expected to provide new capabilities for measurements important to nuclear astrophysics. To carry out this experimental program, various upgrades are planned to the existing experimental apparatus, and a new, third-generation, recoil-mass separator is being constructed.

  18. Solar Irradiance: Recent Results and Future Research Plans

    NASA Astrophysics Data System (ADS)

    Woods, Thomas N.

    2009-05-01

    The solar irradiance, being the radiance integrated over the full disk, is the primary energy input for Earth's environment. Understanding the solar input is key for several terrestrial research topics concerning, to name a few, atmospheric ozone photochemistry, natural forcings on climate change, and improving space weather forecasting. From a solar physics viewpoint, the solar irradiance offers interesting challenges on understanding the sources of the variability of the solar irradiance, which has a strong dependence in wavelength and varies over all time periods from seconds to centuries. Recent solar irradiance results from the TIMED and SORCE satellite missions, such as concerning the current solar cycle minimum, will be presented. In addition, some outstanding questions for solar irradiance research will be addressed within the context of how they can be answered with the new missions, SDO, Glory, and PICARD, that are expected to be launched in late 2009.

  19. [Clinical research on malaria: what for the future?].

    PubMed

    Cot, M

    2005-06-01

    Malaria still remains one of the main public health problems in the world. In spite of early and numerous clinical trials, the situation seems to have been worsening in the last ten years. Malaria clinical research involves several levels: Several meta-analyses have been performed on this topic (in particular, the Cochrane Database Library has published studies on malaria prevention during pregnancy, management of clinical malaria attacks, vaccine trials or impregnated bed net trials). All these studies show the uneven quality of trials (only 10% to 50% can be kept in the analysis for methodological reasons), which seldom lead to similar conclusions. Besides, as resistances of both parasites and vectors to drugs or insecticides are regularly increasing, trials have to be repeated and new molecules have to be found and evaluated. Finally, practical application of such interventions may be difficult, due to the heterogeneity of epidemiological situations and the poverty of target populations. Various initiatives aiming to develop malaria clinical research have recently been launched. Donators are public or international (Global Fund, Roll Back Malaria Initiative, NIH, EDCTP programme), as well as private (Bill & Melinda Gates Foundation). These substantial funds should enhance the research of new antimalarial drugs and large-scale, adequately designed trials. However, to make sure these trials really benefit to populations exposed to the disease, ethical principles should be co-elaborated with developing countries, within collaborative networks between laboratories from industrialized and developing countries. PMID:16227916

  20. Animal Research in Space: Past, Present, and Future

    NASA Astrophysics Data System (ADS)

    Souza, Kenneth; Sun, Sidney; Tomko, David

    Animals, principally non-human primates, were the early pioneers of spaceflight demonstrating that higher organisms could survive the rigors of launch to low earth orbit and the unique microgravity and radiation environment of orbital spaceflight. Following dispelling the fears that spaceflight could cause major disruptions in key body systems, non-human primates gave way to rodent research, particularly rats, in order to increase the number of specimens per flight opportunity, reduce the cost of support equipment, and to focus on how animals adapt to the near absence of gravity. In the virtual absence of gravity, changes were observed in the musculoskeletal system, sensorimotor, cardiovascular, and other systems. To accommodate rodents during spaceflight special facilities had to be developed for both crewed and unscrewed space vehicles. e.g. the Space Shuttle, and free flyers like the Russian Cosmos biosatellites, respectively. With a crew onboard, scientists have the opportunity to use them to obtain samples from the animals, measure physiological function, observe and record animal behavior, and administer drugs or challenges. However, on free flyers one can utilize materials and techniques not possible on crewed spacecraft due to safety, cost, and/or flight resources or competing priorities. This presentation will provide a brief glimpse of some of the highlights in the history of animal research in space, recent results, and current prospects for the next decade, i.e., flight opportunities, rodent habitats, and support equipment for rodent research.

  1. The Heffter Research Institute: past and hopeful future.

    PubMed

    Nichols, David E

    2014-01-01

    This essay describes the founding of the Heffter Research Institute in 1993 and its development up to the present. The Institute is the only scientific research organization dedicated to scientific research into the medical value of psychedelics, and it has particularly focused on the use of psilocybin. The first clinical treatment study was of the value of psilocybin in obsessive-compulsive disorder. Next was a UCLA study of psilocybin to treat end-of-life distress in end-stage cancer patients. While that study was ongoing, a trial was started at Johns Hopkins University (JHU) to study the efficacy of psilocybin in treating anxiety and depression resulting from a cancer diagnosis. Following the successful completion of the UCLA project, a larger study was started at New York University, which is near completion. A pilot study of the value of psilocybin in treating alcoholism at the University of New Mexico also is nearing completion, with a larger two-site study being planned. Other studies underway involve the use of psilocybin in a smoking cessation program and a study of the effects of psilocybin in long-term meditators, both at JHU. The institute is now planning for a Phase 3 clinical trial of psilocybin to treat distress in end-stage cancer patients. PMID:24830182

  2. Zebrafish antipredatory responses: A future for translational research?

    PubMed Central

    Gerlai, Robert

    2011-01-01

    Human neuropsychiatric conditions associated with abnormally exaggerated or misdirected fear (anxiety disorders and phobias) still represent a large unmet medical need because the biological mechanisms underlying these diseases are not well understood. Animal models have been proposed to facilitate this research. Here I review the literature with a focus on zebrafish, an upcoming laboratory organism in behavioral brain research. I argue that abnormal human fear responses are likely the result of the malfunction of neurobiological mechanisms (brain areas, circuits and/or molecular mechanisms) that originally evolved to support avoidance of predators or other harm in nature. I also argue that the understanding of the normal as well as pathological functioning of such mechanisms may be best achieved if one utilizes naturalistic experimental approaches. In case of laboratory model organisms, this may entail presenting stimuli associated with predators and measuring species-specific antipredatory responses. Although zebrafish is a relatively new subject of such inquiry, I review the recently rapidly increasing number of zebrafish studies in this area, and conclude that zebrafish is a promising research tool for the analysis of the neurobiology and genetics of vertebrate fear responses. PMID:19836422

  3. Indian Ocean Research Data: Past, Present and Future

    NASA Astrophysics Data System (ADS)

    Chandler, Cynthia; Groman, Robert; Allison, Molly; Copley, Nancy; Gegg, Stephen; Kinkade, Danie; Rauch, Shannon; Glover, David; Wiebe, Peter

    2015-04-01

    Open access to well-documented data is essential to enable improved understanding of the key processes and their complex interactions in the Indian Ocean. For decades, marine ecosystem data have been collected by expeditions conducting research in this fascinating region. The data from many of the projects including the International Indian Ocean Expedition of the 1960s, the US Joint Global Ocean flux Study (JGOFS) Arabian Sea Expedition of the 1990s, and several more recent projects have been contributed by the original investigators to the Biological and Chemical Oceanography Data Management Office (BCO-DMO). BCO-DMO is funded by the US National Science Foundation to work with marine scientists to improve access to research data and ensure long term preservation of the data that comprise an important part of a research program's legacy. The data are freely available from the Web-accessible BCO-DMO system that supports data discovery, access, display, user-customizable export, and download. The authors will provide an overview of the BCO-DMO data system including examples of the range of data types and an introduction to system capabilities.

  4. Research accomplishments and future goals in particle physics

    NASA Astrophysics Data System (ADS)

    1994-06-01

    This proposal presents the research accomplishments and ongoing activities of Boston University researchers in high energy physics. Some changes have been made in the structure of the program from the previous arrangement of tasks. Task B, Accelerator Design Physics, is being submitted as a separate proposal for an independent grant; this will be consistent with the nature of the research and the source of funding. Boston University is active in seven principal areas: (1) Task A: Colliding Beams - physics of e(sup +)e(sup -) and (anti p)p collisions; (2) Task C: MACRO Experiment - search for magnetic monopoles and study of cosmic rays; (3) Task D: Proton Decay - search for nucleon instability and study of neutrino interactions; (4) Tasks E, J, and N: Particle Theory - theoretical high energy particle physics, including two Outstanding Junior Investigator awards; (5) Task F: Muon G-2 - measurement of the anomalous magnetic moment of the muon; (6) Task K: SSCintcal - calorimetry for the GEM Experiment; (7) Task L: Muon Detectors for the GEM Experiment. The body of the proposal is devoted to detailed discussions of each of the tasks. The total budget request for the program appears in a summary chapter that includes a general budget discussion and individual budget requests and explanations for each of the tasks.

  5. Current status and future prospects of epidemiology and public health training and research in the WHO African region

    PubMed Central

    Nachega, Jean B; Uthman, Olalekan A; Ho, Yuh-Shan; Lo, Melanie; Anude, Chuka; Kayembe, Patrick; Wabwire-Mangen, Fred; Gomo, Exnevia; Sow, Papa Salif; Obike, Ude; Kusiaku, Theophile; Mills, Edward J; Mayosi, Bongani M; IJsselmuiden, Carel

    2012-01-01

    Background To date little has been published about epidemiology and public health capacity (training, research, funding, human resources) in WHO/AFRO to help guide future planning by various stakeholders. Methods A bibliometric analysis was performed to identify published epidemiological research. Information about epidemiology and public health training, current research and challenges was collected from key informants using a standardized questionnaire. Results From 1991 to 2010, epidemiology and public health research output in the WHO/AFRO region increased from 172 to 1086 peer-reviewed articles per annum [annual percentage change (APC) = 10.1%, P for trend < 0.001]. The most common topics were HIV/AIDS (11.3%), malaria (8.6%) and tuberculosis (7.1%). Similarly, numbers of first authors (APC = 7.3%, P for trend < 0.001), corresponding authors (APC = 8.4%, P for trend < 0.001) and last authors (APC = 8.5%, P for trend < 0.001) from Africa increased during the same period. However, an overwhelming majority of respondents (>90%) reported that this increase is only rarely linked to regional post-graduate training programmes in epidemiology. South Africa leads in publications (1978/8835, 22.4%), followed by Kenya (851/8835, 9.6%), Nigeria (758/8835, 8.6%), Tanzania (549/8835, 6.2%) and Uganda (428/8835, 4.8%) (P < 0.001, each vs South Africa). Independent predictors of relevant research productivity were ‘in-country numbers of epidemiology or public health programmes’ [incidence rate ratio (IRR) = 3.41; 95% confidence interval (CI) 1.90–6.11; P = 0.03] and ‘number of HIV/AIDS patients’ (IRR = 1.30; 95% CI 1.02–1.66; P < 0.001). Conclusions Since 1991, there has been increasing epidemiological research productivity in WHO/AFRO that is associated with the number of epidemiology programmes and burden of HIV/AIDS cases. More capacity building and training initiatives in epidemiology are required to promote research and address the public health challenges

  6. Animal biowarfare research: historical perspective and potential future attacks.

    PubMed

    Yeh, Jung-Yong; Park, Jee-Yong; Cho, Yun Sang; Cho, In-Soo

    2012-12-01

    A biological attack on livestock or poultry could result in the loss of valuable animals, costs related to the containment of outbreaks and the disposal of carcasses, lost trade and other economic effects involving suppliers, transporters, distributors and restaurants; however, it is not possible to secure all livestock, and livestock are much less well guarded than human targets. Thus, the vulnerability of the livestock industry to the introduction of biological agents varies for the following reasons: (i) the majority of lethal and contagious biological agents are environmentally resilient, endemic in foreign countries and harmless to humans, making it easier for terrorists to acquire, handle and deploy these pathogens, (ii) with animals concentrated in fewer production facilities and frequently transported between these facilities, a single pathogen introduction could cause widespread infection and (iii) the extent of human travel around the globe makes it difficult to exclude exotic animal diseases as possible biological agents. Historically, many governments have developed and planned to use biological agents for direct attacks on livestock or poultry. In the past, developed nations have actively developed biological weapons to target animals. The potential spectrum of bioterrorism ranges from isolated acts against individuals by individuals to tactical and strategic military attacks and state-sponsored international terrorism intended to cause mass casualties in animals, humans or both. This review provides an overview of the past development and use of biological weapons and describes potential future attacks. PMID:22646760

  7. Melodic intonation therapy: back to basics for future research.

    PubMed

    Zumbansen, Anna; Peretz, Isabelle; Hébert, Sylvie

    2014-01-01

    We present a critical review of the literature on melodic intonation therapy (MIT), one of the most formalized treatments used by speech-language therapist in Broca's aphasia. We suggest basic clarifications to enhance the scientific support of this promising treatment. First, therapeutic protocols using singing as a speech facilitation technique are not necessarily MIT. The goal of MIT is to restore propositional speech. The rationale is that patients can learn a new way to speak through singing by using language-capable regions of the right cerebral hemisphere. Eventually, patients are supposed to use this way of speaking permanently but not to sing overtly. We argue that many treatment programs covered in systematic reviews on MIT's efficacy do not match MIT's therapeutic goal and rationale. Critically, we identified two main variations of MIT: the French thérapie mélodique et rythmée (TMR) that trains patients to use singing overtly as a facilitation technique in case of speech struggle and palliative versions of MIT that help patients with the most severe expressive deficits produce a limited set of useful, readymade phrases. Second, we distinguish between the immediate effect of singing on speech production and the long-term effect of the entire program on language recovery. Many results in the MIT literature can be explained by this temporal perspective. Finally, we propose that MIT can be viewed as a treatment of apraxia of speech more than aphasia. This issue should be explored in future experimental studies. PMID:24478754

  8. Nanoindentation in Materials Research: Past, Present, and Future

    SciTech Connect

    Oliver, Warren; Pharr, George Mathews

    2010-01-01

    The method we introduced in 1992 for measuring hardness and elastic modulus by nanoindentation testing has been widely adopted and used in the characterization of mechanical behavior at small scales. Since its original development, the method has undergone numerous refinements and changes brought about by improvements to testing equipment and techniques, as well as advances in our understanding of the mechanics of elastic-plastic contact. In this article, we briefly review the history of the method, comment on its capabilities and limitations, and discuss some of the emerging areas in materials research where it has played, or promises to play, an important role.

  9. Future research on animal temperatures using electronic equipment

    SciTech Connect

    Nott, S.B.; Seawright, G.L.

    1981-11-01

    Available literature on animal temperature is reviewed and research priorities, using newly developed electronic identification and temperature-sensing equipment, are suggested. Applications to beef-cattle, dairy-cattle, and swine operations receive major attention. Skepticism of existing temperature data obtained with rectal thermometers is expressed. Physiological control of animal temperature is described as is the new monitoring technology (transponders and battery-operated radio transmitters). Primary emphasis is given to the diseases and managerial applications where temperature monitoring equipment is likely to be most profitable.

  10. Microarrays—Current and Future Applications in Biomedical Research

    PubMed Central

    Certa, Ulrich

    2011-01-01

    Microarrays covers research where microarrays are applied to address complex biological questions. This new open access journal publishes articles where novel applications or state-of-the art technology developments in the field are reported. In addition, novel methods or data analysis algorithms are under the scope of Microarrays. This journal will serve as a platform for fast and efficient sharing of data within this large user community. As one of the first microarray users in Europe back in 1996, I am proud to serve as Editor-in-Chief and I believe we have assembled a highly proficient Editorial Board, responsible for a fair and fast peer-review of articles.

  11. Astroinformatics, data mining and the future of astronomical research

    NASA Astrophysics Data System (ADS)

    Brescia, Massimo; Longo, Giuseppe

    2013-08-01

    Astronomy, as many other scientific disciplines, is facing a true data deluge which is bound to change both the praxis and the methodology of every day research work. The emerging field of astroinformatics, while on the one end appears crucial to face the technological challenges, on the other is opening new exciting perspectives for new astronomical discoveries through the implementation of advanced data mining procedures. The complexity of astronomical data and the variety of scientific problems, however, call for innovative algorithms and methods as well as for an extreme usage of ICT technologies.

  12. Research directions for future generations of cochlear implants.

    PubMed

    Clark, Graeme

    2004-09-01

    Physiological and psychophysical research indicates that improved hearing in noise and music appreciation are likely with cochlear implants, with better reproduction of the fine temporospatial patterns of neural response in the auditory pathways due to phase differences in neuron firing patterns as the result of the basilar membrane travelling wave. An initial speech-processing strategy, to in part reproduce this information, is showing better frequency discrimination and musical perception. However, more exact reproduction is likely with a new generation electrode array which could involve the use of neurotrophins and inherently conducting polymers. The siting and design of this, as well as safety, needs further investigation before it is implemented. PMID:18792214

  13. Melodic Intonation Therapy: Back to Basics for Future Research

    PubMed Central

    Zumbansen, Anna; Peretz, Isabelle; Hébert, Sylvie

    2014-01-01

    We present a critical review of the literature on melodic intonation therapy (MIT), one of the most formalized treatments used by speech-language therapist in Broca’s aphasia. We suggest basic clarifications to enhance the scientific support of this promising treatment. First, therapeutic protocols using singing as a speech facilitation technique are not necessarily MIT. The goal of MIT is to restore propositional speech. The rationale is that patients can learn a new way to speak through singing by using language-capable regions of the right cerebral hemisphere. Eventually, patients are supposed to use this way of speaking permanently but not to sing overtly. We argue that many treatment programs covered in systematic reviews on MIT’s efficacy do not match MIT’s therapeutic goal and rationale. Critically, we identified two main variations of MIT: the French thérapie mélodique et rythmée (TMR) that trains patients to use singing overtly as a facilitation technique in case of speech struggle and palliative versions of MIT that help patients with the most severe expressive deficits produce a limited set of useful, readymade phrases. Second, we distinguish between the immediate effect of singing on speech production and the long-term effect of the entire program on language recovery. Many results in the MIT literature can be explained by this temporal perspective. Finally, we propose that MIT can be viewed as a treatment of apraxia of speech more than aphasia. This issue should be explored in future experimental studies. PMID:24478754

  14. Current trends and future directions in flower development research

    PubMed Central

    Scutt, Charlie P.; Vandenbussche, Michiel

    2014-01-01

    Flowers, the reproductive structures of the approximately 400 000 extant species of flowering plants, exist in a tremendous range of forms and sizes, mainly due to developmental differences involving the number, arrangement, size and form of the floral organs of which they consist. However, this tremendous diversity is underpinned by a surprisingly robust basic floral structure in which a central group of carpels forms on an axis of determinate growth, almost invariably surrounded by two successive zones containing stamens and perianth organs, respectively. Over the last 25 years, remarkable progress has been achieved in describing the molecular mechanisms that control almost all aspects of flower development, from the phase change that initiates flowering to the final production of fruits and seeds. However, this work has been performed almost exclusively in a small number of eudicot model species, chief among which is Arabidopsis thaliana. Studies of flower development must now be extended to a much wider phylogenetic range of flowering plants and, indeed, to their closest living relatives, the gymnosperms. Studies of further, more wide-ranging models should provide insights that, for various reasons, cannot be obtained by studying the major existing models alone. The use of further models should also help to explain how the first flowering plants evolved from an unknown, although presumably gymnosperm-like ancestor, and rapidly diversified to become the largest major plant group and to dominate the terrestrial flora. The benefits for society of a thorough understanding of flower development are self-evident, as human life depends to a large extent on flowering plants and on the fruits and seeds they produce. In this preface to the Special Issue, we introduce eleven articles on flower development, representing work in both established and further models, including gymnosperms. We also present some of our own views on current trends and future directions of the

  15. Exploring Astrobiology: Future and In-Service Teacher Research Experiences

    NASA Astrophysics Data System (ADS)

    Cola, J.; Williams, L. D.; Snell, T.; Gaucher, E.; Harris, B.; Usselman, M. C.; Millman, R. S.

    2009-12-01

    The Georgia Tech Center for Ribosome Adaptation and Evolution, a center funded by the NASA Astrobiology Institute, developed an educational Astrobiology program titled, “Life on the Edge: Astrobiology.” The purpose of the program was to provide educators with the materials, exposure, and skills necessary to prepare our future workforce and to foster student interest in scientific discovery on Earth and throughout the universe. A one-week, non-residential summer enrichment program for high school students was conducted and tested by two high school educators, an undergraduate student, and faculty in the Schools of Biology, and Chemistry and Biochemistry at Georgia Tech. In an effort to promote and encourage entry into teaching careers, Georgia Tech paired in-service teachers in the Georgia Intern-Fellowship for Teachers (GIFT) program with an undergraduate student interested in becoming a teacher through the Tech to Teaching program. The GIFT and Tech to Teaching fellows investigated extremophiles which have adapted to life under extreme environmental conditions. As a result, extremophiles became the focus of a week-long, “Life on the Edge: Astrobiology” curriculum aligned with the Georgia Performance Standards in Biology. Twenty-five high school students explored the adaptation and survival rates for various types of extremophiles exposed to UV radiation and desiccation; students were also introduced to hands-on activities and techniques such as genomic DNA purification, gel electrophoresis, and Polymerase Chain Reaction (PCR). The impact on everyone invested and involved in the Astrobiology program including the GIFT and Tech to Teaching fellows, high school students, and faculty are discussed.

  16. The Research of Computer Aided Farm Machinery Designing Method Based on Ergonomics

    NASA Astrophysics Data System (ADS)

    Gao, Xiyin; Li, Xinling; Song, Qiang; Zheng, Ying

    Along with agricultural economy development, the farm machinery product type Increases gradually, the ergonomics question is also getting more and more prominent. The widespread application of computer aided machinery design makes it possible that farm machinery design is intuitive, flexible and convenient. At present, because the developed computer aided ergonomics software has not suitable human body database, which is needed in view of farm machinery design in China, the farm machinery design have deviation in ergonomics analysis. This article puts forward that using the open database interface procedure in CATIA to establish human body database which aims at the farm machinery design, and reading the human body data to ergonomics module of CATIA can product practical application virtual body, using human posture analysis and human activity analysis module to analysis the ergonomics in farm machinery, thus computer aided farm machinery designing method based on engineering can be realized.

  17. Research on ultrasonic vibration aided femtosecond laser machining process of transparent materials

    NASA Astrophysics Data System (ADS)

    Dai, Yutang; Liu, Bin; Yin, Guanglin; Li, Tao; Karanja, Joseph M.

    2015-08-01

    A new process of femtosecond laser micromachining with ultrasonic vibration aided is proposed. An ultrasonic aided device has been designed, and the laser micromachining experiments of transparent materials have been carried out. The effects of the ultrasonic vibration with different power on surface quality and the drilling depth have been investigated, and the mechanism of the ultrasonic vibration aided laser machining has been analyzed. After introducing the ultrasonic vibration device, the residue debris on surface of the ablated trench is significantly reduced, and the drilling depth is increased. These results show that, ultrasonic vibration can effectively improve the surface quality of material processing, increase the depth of the drilling hole and promote the processing efficiency of the femtosecond laser.

  18. Fatigue in Multiple Sclerosis: Misconceptions and Future Research Directions

    PubMed Central

    Rudroff, Thorsten; Kindred, John H.; Ketelhut, Nathaniel B.

    2016-01-01

    Fatigue is one of the most disabling side effects in people with multiple sclerosis. While this fact is well known, there has been a remarkable lack of progress in determining the pathophysiological mechanisms behind fatigue and the establishment of effective treatments. The main barrier has been the lack of a unified definition of fatigue that can be objectively tested with validated experimental models. In this “perspective article” we propose the use of the following model and definition of fatigue: the decrease in physical and/or mental performance that results from changes in central, psychological, and/or peripheral factors. These changes depend on the task being performed, the environmental conditions it is performed in, and the physical and mental capacity of the individual. Our definition and model of fatigue outlines specific causes of fatigue and how it affects task performance. We also outline the strengths and weaknesses of commonly used measures of fatigue and suggest, based on our model and definition, new research strategies, which should include multiple measures. These studies should be mechanistic with validated experimental models to determine changes in central, psychological, and/or peripheral factors that explain fatigue. The proposed new research strategies may lead to the identification of the origins of MS related fatigue and the development of new, more effective treatments. PMID:27531990

  19. Fatigue in Multiple Sclerosis: Misconceptions and Future Research Directions.

    PubMed

    Rudroff, Thorsten; Kindred, John H; Ketelhut, Nathaniel B

    2016-01-01

    Fatigue is one of the most disabling side effects in people with multiple sclerosis. While this fact is well known, there has been a remarkable lack of progress in determining the pathophysiological mechanisms behind fatigue and the establishment of effective treatments. The main barrier has been the lack of a unified definition of fatigue that can be objectively tested with validated experimental models. In this "perspective article" we propose the use of the following model and definition of fatigue: the decrease in physical and/or mental performance that results from changes in central, psychological, and/or peripheral factors. These changes depend on the task being performed, the environmental conditions it is performed in, and the physical and mental capacity of the individual. Our definition and model of fatigue outlines specific causes of fatigue and how it affects task performance. We also outline the strengths and weaknesses of commonly used measures of fatigue and suggest, based on our model and definition, new research strategies, which should include multiple measures. These studies should be mechanistic with validated experimental models to determine changes in central, psychological, and/or peripheral factors that explain fatigue. The proposed new research strategies may lead to the identification of the origins of MS related fatigue and the development of new, more effective treatments. PMID:27531990

  20. Disaggregated Data and Beyond: Future Queries in Cancer Control Research

    PubMed Central

    Nguyen, Anh Bao; Chawla, Neetu; Noone, Anne-Michelle; Srinivasan, Shobha

    2014-01-01

    The goal of health equity requires the collection and reporting of disaggregated data in underrepresented populations such as Asian American (AA) and Native Hawaiian and Other Pacific Islander (NHOPI) communities. A recent Department of Health and Human Services report outlines the necessity for disaggregated data which would offer communities, providers and planners better tools to address health problems. In a recent collaboration, the National Cancer Institute (NCI) and several registries published a series of papers tracking cancer incidence data on AA and NHOPI communities using data from the NCI’s Surveillance and Epidemiology and End Results (SEER) program. The findings indicate a need for concentrated focus and planning for the next stages of cancer prevention and control for AA and NHOPI subpopulations. In this article, we provide (a) the context for the perpetuation of the model minority myth as well as historical and socio-cultural factors that have shaped health and disease for AA and NHOPI subgroups; (b) potential strategies for research and public health policy for AA and NHOPI groups using subpopulation-based approaches while addressing challenges and limitations; and (c) a portfolio analysis of currently funded projects within the NCI/DCCPS to identify gaps and areas of potential research. PMID:25368401

  1. Applying research to AIDS programs in villages. Burkina Faso project learns from community survey.

    PubMed

    Tankoano, F

    1994-01-01

    In 1991, 34 cases of acquired immunodeficiency syndrome (AIDS) were recorded for the province of Bam, which has a population of 4239. Since 1992, PLAN and the local Ministry of Health have been conducting an AIDS prevention program in the province. An initial baseline community survey to assess knowledge, attitude, and practices about the disease was conducted in order to tailor the program to the needs and characteristics of the target population. A questionnaire was administered to 300 randomly selected adults in 10 rural villages. The sexes were equally represented. 74% of the villagers were found to be illiterate and the major sources of health information were radio, health facilities, and friends and relatives; therefore, educational activities were carried out through non-written methods (traditional and modern) that employed these communication channels. Initially, 5 men and 5 women ("Village Communicators") were selected by their communities to be trained in information, education, and communication (IEC) techniques regarding AIDS prevention; under the supervision of their trainers, they organized and conducted 2 weekly sessions. An additional 62 women and 50 men were trained as Village Communicators to promote AIDS awareness among their own gender. A team of health personnel, artists, and a traditional music group conducted collective sessions to promote condom use and address problems relating to AIDS (polygamy, remarrying of spouses of AIDS victims, availability of testing during prenuptial visits). Although 90% of respondents had heard about AIDS, 30% did not understand the disease or its routes of transmission; so messages about the effects and the transmission of AIDS were emphasized. Because 56% of respondents admitted having had 2 or more sex partners, and a similar percentage admitted having had 2 or more sexual encounters per week, messages were disseminated on sexuality using community volunteers and the folkloric band. 42% of respondents were

  2. Future Research Directions for Multimorbidity Involving Cardiovascular Diseases.

    PubMed

    Salive, Marcel E

    2016-05-01

    Multimorbidity, defined as the co-occurrence of two or more chronic conditions, increases with age and may be found in approximately two-thirds of older adults in population studies, commonly including a variety of cardiovascular risk factors and chronic diseases. This article offers a research agenda for cardiovascular disease from a patient-centered multimorbidity perspective. Definitional issues remain for multimorbidity, along with high interest in understanding the inter-relationships between aging, diseases, treatments, and organ dysfunction in the development and progression of multimorbidity. Clinical trials, practice-based and population-based observational studies, and linkages of big data can play a role in improving health outcomes among persons with multimorbidity. PMID:27113155

  3. Electroactive Biofilms: Current Status and Future Research Needs

    SciTech Connect

    Borole, Abhijeet P; Reguera, Gemma; Ringeisen, Bradley; Wang, Zhiwu; Feng, Yujie; Kim, Byung Hong

    2011-01-01

    Electroactive biofilms generated by electrochemically active microorganisms have many potential applications in bioenergy and chemicals production. This review assesses the effects of microbiological and process parameters on enrichment of such biofilms as well as critically evaluates the current knowledge of the mechanisms of extracellular electron transfer in BES systems. First we discuss the role of biofilm forming microorganisms vs. planktonic microorganisms. Physical, chemical and electrochemical parameters which dictate the enrichment and subsequent performance of the biofilms are discussed. Potential dependent biological parameters including biofilm growth rate, specific electron transfer rate and others and their relationship to BES system performance is assessed. A review of the mechanisms of electron transfer in BES systems is included followed by a discussion of biofilm and its exopolymeric components and their electrical conductivity. A discussion of the electroactive biofilms in biocathodes is also included. Finally, we identify the research needs for further development of the electroactive biofilms to enable commercial applications.

  4. Concrete-polymer composites: current status and future research needs

    SciTech Connect

    Kukacka, L E

    1981-04-01

    When plastics are combined with mixtures of inorganic materials, high-strength, durable, fast-setting composites are produced. These materials are used in structural engineering and other applications, and as a result of the successes obtained to date, considerable research and development work is in progress throughout the world. One family of polymer-based composites receiving considerable attention is the concrete-polymer materials. Work in this area is directed toward developing new high-strength durable materials by combining cement and concrete technology with that of polymer chemistry. In addition to the significant property enhancement, many combinations of siliceous materials with polymers require lower energy inputs per unit of performance than either component alone.

  5. Enhancing water cycle measurements for future hydrologic research

    USGS Publications Warehouse

    Loescher, H.W.; Jacobs, J.M.; Wendroth, O.; Robinson, D.A.; Poulos, G.S.; McGuire, K.; Reed, P.; Mohanty, B.P.; Shanley, J.B.; Krajewski, W.

    2007-01-01

    The Consortium of Universities for the Advancement of Hydrologic Sciences, Inc., established the Hydrologic Measurement Facility to transform watershed-scale hydrologic research by facilitating access to advanced instrumentation and expertise that would not otherwise be available to individual investigators. We outline a committee-based process that determined which suites of instrumentation best fit the needs of the hydrological science community and a proposed mechanism for the governance and distribution of these sensors. Here, we also focus on how these proposed suites of instrumentation can be used to address key scientific challenges, including scaling water cycle science in time and space, broadening the scope of individual subdisciplines of water cycle science, and developing mechanistic linkages among these subdisciplines and spatio-temporal scales. ?? 2007 American Meteorological Society.

  6. A look into the future of ALS research.

    PubMed

    Clerc, Pascaline; Lipnick, Scott; Willett, Catherine

    2016-06-01

    Although amyotrophic lateral sclerosis (ALS), also referred as 'Lou Gehrig's Disease,' was first described in 1869 and the first disease-associated gene was discovered almost 20 years ago, the disease etiology is still not fully understood and treatment options are limited to one drug approved by the US Food and Drug Administration (FDA). The slow translational progress suggests that current research models are not ideal to study such a complicated disease and need to be re-examined. Progress will require greater insight into human genes and biology involved in ALS susceptibility, as well as a deeper understanding of disease phenotype at the histological and molecular levels. Improving human disease outcome will require directing focus toward improved assessment technologies and innovative approaches. PMID:26861067

  7. Research in mosquito control: current challenges for a brighter future.

    PubMed

    Benelli, Giovanni

    2015-08-01

    Mosquitoes (Diptera: Culicidae) are a key threat for millions of people worldwide, since they act as vectors for devastating pathogens and parasites. In this scenario, vector control is crucial. Mosquito larvae are usually targeted using organophosphates, insect growth regulators, and microbial agents. Indoor residual spraying and insecticide-treated bed nets are also employed. However, these chemicals have negative effects on human health and the environment and induce resistance in a number of vectors. Newer and safer tools have been recently implemented to enhance control of mosquitoes. Here, I focus on some crucial challenges about eco-friendly control of mosquito vectors, mainly the improvement of behavior-based control strategies (sterile insect technique ("SIT") and "boosted SIT") and plant-borne mosquitocidals, including green-synthesized nanoparticles. A number of hot areas that need further research and cooperation among parasitologists, entomologists, and behavioral ecologists are highlighted. PMID:26093499

  8. Some thoughts on future directions in margin research

    SciTech Connect

    Mutter, J.C. )

    1990-05-01

    Looking through the abstracts of presentations for this symposium, the authors see a science in transition. The quarter century since plate tectonic theory provided geoscience with a guiding framework in which to carry forward research into global tectonic phenomenon has witnessed a flourishing of research into the structure and evolution of continental margins. Margin evolution can now be placed firmly within this theoretical construct, thereby providing one of the key elaborations of the original theory that has given it its strength and value. What, then, is the next stage Are they in a period of normal science characterized by the detailed verification of an established paradigm, or can they hope for a really new direction Two approaches seem to present themselves. One is to focus attention on anomalies-things that don't quite fit or are not very easily covered by the present paradigm. Volcanic passive margins don't fit very well within the simple kinematic statement of plate tectonics, nor do eustasy and its effect on sedimentary sequences. While study of these square pegs in the round hole of plate theory may not bring them to a new paradigm, they might well provide significant modifications to the current wisdom. Perhaps a more fruitful approach is to propose that they are at a point in the development of other science at which the era of verification of the plate tectonic paradigm is sufficiently mature (perhaps even at its end) that the proper direction now is to establish a rigorous physical basis for the phenomena that are kinematically described by plate theory. The objective should be to created a higher order theory and thereby illuminate these known phenomena. Numerical and analytical modeling of deformational processes, magma generation, and migration are making leading contributions to this endeavor.

  9. Future Soil Moisture Satellite Missions and Research Needs

    NASA Astrophysics Data System (ADS)

    Njoku, E. G.; Jackson, T. J.; O'Neill, P. E.

    2001-12-01

    many opportunities, and research needs, to be addressed in developing innovative approaches to utilization of the new satellite-derived data. Issues include development of new processing and retrieval algorithms, methods for jointly assimilating satellite-derived and in-situ data into hydrologic models, and validation of derived soil moisture data and products. An overview of the current soil moisture mission and planning status, and ongoing and needed research, will be provided in this paper.

  10. Soil Contamination and Remediation Strategies. Current research and future challenge

    NASA Astrophysics Data System (ADS)

    Petruzzelli, G.

    2012-04-01

    eliminating the source of pollution, but also on blocking the pathways from contaminants to receptors or reducing the exposure to contaminants,. Future challenge integration of sustainability into remediation decision-making. Soil is not a waste! There is a growing interest in the clean up approaches that maintain soil quality after remediation treatments. This issue is of great importance in the U.S.A. where the EPA from 2009 is promoting innovative clean-up strategies (Green Remediation). Green remediation is defined as the practice of considering all environmental effects of remedy and incorporating options to maximize environmental benefit of cleanup actions . These remediation strategies restore contaminated sites to productive use with a great attention to the global environmental quality, including the preservation of soil functionality according to the following principles: use minimally invasive technologies; use passive energy technologies such as bioremediation and phytoremediation as primary remedies or finishing steps where possible and effective; minimize soil and habitat disturbance; minimize bioavailability of contaminants trough adequate contaminant source and plume control If we move from the current definition of remedial targets based on total concentrations, technologies with low impact on the environment can be utilized reducing the wrong choice to disposal soil in landfill destroying quickly a not renewable essential resource.

  11. Computer-Aided Drug Design (CADD): Methodological Aspects and Practical Applications in Cancer Research

    NASA Astrophysics Data System (ADS)

    Gianti, Eleonora

    Computer-Aided Drug Design (CADD) has deservedly gained increasing popularity in modern drug discovery (Schneider, G.; Fechner, U. 2005), whether applied to academic basic research or the pharmaceutical industry pipeline. In this work, after reviewing theoretical advancements in CADD, we integrated novel and stateof- the-art methods to assist in the design of small-molecule inhibitors of current cancer drug targets, specifically: Androgen Receptor (AR), a nuclear hormone receptor required for carcinogenesis of Prostate Cancer (PCa); Signal Transducer and Activator of Transcription 5 (STAT5), implicated in PCa progression; and Epstein-Barr Nuclear Antigen-1 (EBNA1), essential to the Epstein Barr Virus (EBV) during latent infections. Androgen Receptor. With the aim of generating binding mode hypotheses for a class (Handratta, V.D. et al. 2005) of dual AR/CYP17 inhibitors (CYP17 is a key enzyme for androgens biosynthesis and therefore implicated in PCa development), we successfully implemented a receptor-based computational strategy based on flexible receptor docking (Gianti, E.; Zauhar, R.J. 2012). Then, with the ultimate goal of identifying novel AR binders, we performed Virtual Screening (VS) by Fragment-Based Shape Signatures, an improved version of the original method developed in our Laboratory (Zauhar, R.J. et al. 2003), and we used the results to fully assess the high-level performance of this innovative tool in computational chemistry. STAT5. The SRC Homology 2 (SH2) domain of STAT5 is responsible for phospho-peptide recognition and activation. As a keystone of Structure-Based Drug Design (SBDD), we characterized key residues responsible for binding. We also generated a model of STAT5 receptor bound to a phospho-peptide ligand, which was validated by docking publicly known STAT5 inhibitors. Then, we performed Shape Signatures- and docking-based VS of the ZINC database (zinc.docking.org), followed by Molecular Mechanics Generalized Born Surface Area (MMGBSA

  12. Sleep disturbance due to noise: current issues and future research.

    PubMed

    Hume, Ken

    2010-01-01

    There is growing interest in carrying out further research to understand and reduce the impact of aircraft noise on airport neighborhood in anticipation of the projected substantial increase in global aviation. Soundscapes provide new analytical methods and a broader, more comprehensive appreciation of the aural environment, which may have a useful role in understanding noise-induced sleep disturbance and annoyance. Current noise metrics like Leq do not provide a common language to report noise environment to residents, which is a key obstacle to effective noise management and acceptance. Non-auditory effects complicate the production of consistent dose-response functions for aircraft noise affecting sleep and annoyance. There are various end-points that can be chosen to assess the degree of sleep disturbance, which has detracted from the clarity of results that has been communicated to wider audiences. The World Health Organization (WHO-Europe) has produced Night Noise Guidelines for Europe, which act as a clear guide for airports and planners to work towards. Methodological inadequacies and the need for simpler techniques to record sleep will be considered with the exciting potential to greatly increase cost-effective field data acquisition, which is needed for large scale epidemiological studies. PMID:20472952

  13. Asthma in the Elderly: Current Understanding and Future Research Needs

    PubMed Central

    Hanania, Nicola A.; King, Monroe J.; Braman, Sidney S.; Saltoun, Carol; Wise, Robert A.; Enright, Paul; Falsey, Ann A; Mathur, Sameer K.; Ramsdell, Joe W.; Rogers, Linda; Stempel, David A.; Lima, John J.; Fish, James E.; Wilson, Sandra R.; Boyd, Cynthia; Patel, Kushang V.; Irvin, Charles G.; Yawn, Barbara P.; Halm, Ethan A; Wasserman, Stephen I.; Sands, Mark F.; Ershler, William B.; Ledford, Dennis K.

    2011-01-01

    Asthma in the elderly (AIE) is under diagnosed and under treated and there is a paucity of knowledge. The National Institute on Aging convened this workshop to identify what is known, what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of AIE. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger individuals but co-morbid illnesses and the psychosocial effects of aging may affect the diagnosis, clinical presentation and care of asthma in this population. At least two phenotypes exist among elderly asthma; those with long-standing asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiological mechanisms of AIE are likely to be different from those seen in young asthmatics and these differences may influence the clinical course and outcomes of asthma in this population. PMID:21872730

  14. European Fusion Materials Research Program - Recent Results and Future Strategy

    SciTech Connect

    Diegele, E.; Andreani, R.; Laesser, R.; Schaaf, B. van der

    2005-05-15

    The paper reviews the objectives and the status of the current EU long-term materials program. It highlights recent results, discusses some of the key issues and major existing problems to be resolved and presents an outlook on the R and D planned for the next few years. The main objectives of the Materials Development program are the development and qualification of reduced activation structural materials for the Test Blanket Modules (TBMs) in ITER and of low activation structural materials resistant to high fluence neutron irradiation for in-vessel components such as breeding blanket, divertor and first wall in DEMO. The EU strategy assumes: (i) ITER operation starting in 2015 with DEMO relevant Test Blanket Modules to be installed from day one of operation, (ii) IFMIF operation in 2017 and (iii) DEMO final design activities in 2022 to 2025. The EU candidate structural material EUROFER for TBMs has to be fully code qualified for licensing well before 2015. In parallel, research on materials for operation at higher temperatures is conducted following a logical sequence, by supplementing EUROFER with the oxide dispersion strengthened ferritic steels and, thereafter, with fibre-reinforced Silicon Carbide (SiC{sub f}/SiC). Complementary, tungsten alloys are developed as structural material for high temperature applications such as gas-cooled divertors.

  15. Why is Neuroimmunopharmacology crucial for the future of addiction research?

    PubMed Central

    Hutchinson, Mark R; Watkins, Linda R

    2013-01-01

    A major development in drug addiction research in recent years has been the discovery that immune signaling within the central nervous system contributes significantly to mesolimbic dopamine reward signaling induced by drugs of abuse, and hence is involved in the presentation of reward behaviors. Additionally, in the case of opioids, these hypotheses have advanced through to the discovery of the novel site of opioid action at the innate immune pattern recognition receptor Toll-like receptor 4 as the necessary triggering event that engages this reward facilitating central immune signaling. Thus, the hypothesis of major proinflammatory contributions to drug abuse was born. This review will examine these key discoveries, but also address several key lingering questions of how central immune signaling is able to contribute in this fashion to the pharmacodynamics of drugs of abuse. It is hoped that by combining the collective wisdom of neuroscience, immunology and pharmacology, into Neuroimmunopharmacology, we may more fully understanding the neuronal and immune complexities of how drugs of abuse, such as opioids, create their rewarding and addiction states. Such discoveries will point us in the direction such that one day soon we might successfully intervene to successfully treat drug addiction. PMID:23764149

  16. Promising future for the transgenic rat in transplantation research.

    PubMed

    Doorschodt, B M; Teubner, A; Kobayashi, E; Tolba, R H

    2014-10-01

    The rat is the most widely used animal species in surgical research and offers distinct advantages over the mouse in transplantation models due to its size and close genetic similarity to humans. Sequencing of the rat genome and successful application of transgenic technologies which had only been available for mice have since led to a resurgence of the use of rat models. Transplantation provides the possibility to deliver transgenes through a variety of routes which can potentially offer treatment modalities for post-transplant dysfunction and rejection. Moreover, the use of genetically encoded fluorescent light probes has enabled in vivo visualization of organs and tissue in living animals. In recent years, generation of gene knockout rats via the zinc-finger nuclease (ZFN) and transcription activator-like effector nuclease (TALEN) technologies has offered alternatives to the sophisticated embryonic stem cell based gene-targeting. In this review, we aim to provide an overview of transplantation studies involving transgenic techniques using rat models and recent advances in methods to modify the rat genome. Through novel gene modification techniques, precise, complete and conditional knockout and knockin rat models have become available which can provide promising new treatment options and opportunities for studying human transplant-related pathophysiology. PMID:24975516

  17. Gestational diabetes mellitus. Unresolved issues and future research directions.

    PubMed Central

    Okun, N.; Verma, A.; Demianczuk, N.

    1997-01-01

    OBJECTIVE: To summarize the controversial aspects of gestational diabetes (GDM) and introduce readers to possible relevant research questions that could be examined to provide clinicians with good-quality data on which to base decisions about this relatively common pregnancy-related issue. DATA SOURCES AND STUDY SELECTION: Ongoing review of the English literature related to GDM. Sources were not restricted to prospective, controlled trials, as these are severely limited in number. SYNTHESIS: Controversial issues include the relevance of GDM to clinically meaningful outcomes in the index pregnancy, the effectiveness of current therapy in altering these outcomes, and the resultant questionable relevance of routine screening and diagnosis of an entity with as yet uncertain significance in pregnancy. CONCLUSIONS: Suggested questions to be addressed in multicentre controlled trials include randomization with respect to screening and with respect to treatment. Until such trials are completed, continuing with a standard approach to screening, diagnosis, and treatment, such as that suggested by the third international workshop on GDM, is recommended. PMID:9626427

  18. CRYRING@ESR: present status and future research

    NASA Astrophysics Data System (ADS)

    Lestinsky, M.; Bräuning-Demian, A.; Danared, H.; Engström, M.; Enders, W.; Fedotova, S.; Franzke, B.; Heinz, A.; Herfurth, F.; Källberg, A.; Kester, O.; Litvinov, Y.; Steck, M.; Reistad, D.; Simonsson, A.; Skeppstedt, Ö.; Stöhlker, T.; Vorobjev, G.; the CRYRING@ESR working Group

    2015-11-01

    The former storage ring CRYRING has been shipped from the Manne Siegbahn Laboratory in Stockholm to Darmstadt as a Swedish in-kind contribution to FAIR. At its new location downstream of ESR all ion species presently accessible in ESR can be transferred to CRYRING, in which ions with rigidities between 1.44 and 0.054 Tm can be stored. The original Swedish layout has been modified by reconfiguring the sequence of straight sections and by slightly increasing the circumference to ESR/2. Ions can be injected from ESR or from an independent 300 keV/u RFQ test injector. The instrumentation of the ring includes an RF drift tube system for acceleration and deceleration (1 T s-1, with a possibility for an upgrade to 7 T s-1), electron cooling, a free experimental section, and both fast and slow extraction of ions. We report on the present progress of this project, give a prospective timeline, and summarize the new research which will be enabled by this project. First beam for commissioning of the storage ring is expected for 2015, final bakeout to restore ultrahigh vacuum conditions in 2016 and ion beams injected through ESR in ˜2017.

  19. Future Marine Polar Research Capacities - Science Planning and Research Services for a Multi-National Research Icebreaker

    NASA Astrophysics Data System (ADS)

    Biebow, N.; Lembke-Jene, L.; Wolff-Boenisch, B.; Bergamasco, A.; De Santis, L.; Eldholm, O.; Mevel, C.; Willmott, V.; Thiede, J.

    2011-12-01

    Despite significant advances in Arctic and Antarctic marine science over the past years, the polar Southern Ocean remains a formidable frontier due to challenging technical and operational requirements. Thus, key data and observations from this important region are still missing or lack adequate lateral and temporal coverage, especially from time slots outside optimal weather seasons and ice conditions. These barriers combined with the obligation to efficiently use financial resources and funding for expeditions call for new approaches to create optimally equipped, but cost-effective infrastructures. These must serve the international science community in a dedicated long-term mode and enable participation in multi-disciplinary expeditions, with secured access to optimally equipped marine platforms for world-class research in a wide range of Antarctic science topics. The high operational and technical performance capacity of a future joint European Research Icebreaker and Deep-sea Drilling Vessel (the AURORA BOREALIS concept) aims at integrating still separately operating national science programmes with different strategic priorities into joint development of long-term research missions with international cooperation both in Arctic and Antarctica. The icebreaker is planned to enable, as a worldwide first, autonomous year-round operations in the central Arctic and polar Southern Ocean, including severest ice conditions in winter, and serving all polar marine disciplines. It will facilitate the implementation of atmospheric, oceanographic, cryospheric or geophysical observatories for long-term monitoring of the polar environment. Access to the biosphere and hydrosphere e.g. beneath ice shelves or in remote regions is made possible by acting as advanced deployment platform for instruments, robotic and autonomous vehicles and ship-based air operations. In addition to a report on the long-term strategic science and operational planning objectives, we describe foreseen

  20. Research in Online and Blended Learning in the Business Disciplines: Key Findings and Possible Future Directions

    ERIC Educational Resources Information Center

    Arbaugh, J. B.; Godfrey, Michael R.; Johnson, Marianne; Pollack, Birgit Leisen; Niendorf, Bruce; Wresch, William

    2009-01-01

    In this literature review, we examine and assess the state of research of online and blended learning in the business disciplines with the intent of assessing the state of the field and identifying opportunities for meaningful future research. We review research from business disciplines such as Accounting, Economics, Finance, Information Systems…

  1. The Future of Research Publishing: The eReport and eJournal.

    ERIC Educational Resources Information Center

    Krantz, Murray

    2003-01-01

    Considers the future of online publication of scientific journals and how electronic research reports (eReports) and electronic research journals (eJournals) will change the way research is reported, disseminated, consumed, and conducted by the scientific community. Suggests there will be a more interactive dynamic discourse between authors and…

  2. The Past, Present and Future for the Early Childhood Education Researcher.

    ERIC Educational Resources Information Center

    Almy, Millie

    This paper reviews past research in the area of early childhood education, points out current realities, and suggests future possibilities for investigation. Description of past research draws on the yearbooks of the National Society for the Study of Education and such sources as the "Handbook of Research in Early Childhood Education," edited by…

  3. Introductory Course Based on a Single Problem: Learning Nucleic Acid Biochemistry from AIDS Research

    ERIC Educational Resources Information Center

    Grover, Neena

    2004-01-01

    In departure from the standard approach of using several problems to cover specific topics in a class, I use a single problem to cover the contents of the entire semester-equivalent biochemistry classes. I have developed a problem-based service-learning (PBSL) problem on HIV/AIDS to cover nucleic acid concepts that are typically taught in the…

  4. Campus-Based Practices for Promoting Student Success: Financial Aid. Research Brief

    ERIC Educational Resources Information Center

    Horn, Aaron S.; Reinert, Leah

    2014-01-01

    Financial aid may be particularly critical for promoting full-time enrollment, continuous enrollment, and a manageable balance of school and work responsibilities, which influence the likelihood of timely degree completion (Adelman, 2006; Attewell, Heil, & Reisel, 2012; Hossler et al., 2009). For example, Attewell, Heil, and Reisel (2012)…

  5. The Impact of Student Aid on Recruitment and Retention: What the Research Indicates.

    ERIC Educational Resources Information Center

    St. John, Edward P.

    2000-01-01

    Reviews literature on the relationship between student aid, college choice, and students' ability to continue their enrollment. Suggests colleges must invent their own financial resources to remain competitive. Discusses the problem of some students having to be periodic consumers (attending when they can afford it). Describes how an understanding…

  6. Hearing Aid Satisfaction: What Does Research from the Past 20 Years Say?

    PubMed Central

    Wong, Lena L. N.; Hickson, Louise; McPherson, Bradley

    2003-01-01

    Hearing aid satisfaction is a pleasurable emotional experience as an outcome of an evaluation of performance. Many tools have been designed to measure the degree of satisfaction overall, or along the dimensions of cost, appearance, acoustic benefit, comfort, and service. Various studies have used these tools to examine the relationships between satisfaction and other factors. Findings are not always consistent across studies, but in general, hearing aid satisfaction has been found to be related to experience, expectation, personality and attitude, usage, type of hearing aids, sound quality, listening situations, and problems in hearing aid use. Inconsistent findings across studies and difficulties in evaluating the underlying relationships are probably caused by problems with the tools (eg, lack of validity) and the methods used to evaluate relationships (eg, correlation analyses evaluate association and not causal effect). Whether satisfaction changes over time and how service satisfaction contributes to device satisfaction are unclear. It is hoped that this review will help readers understand current satisfaction measures, how various factors affect satisfaction, and how the way satisfaction is measured may be improved to yield more reliable and valid data. PMID:15004650

  7. Ecosystem functioning in the Mozambique Channel: Synthesis and future research

    NASA Astrophysics Data System (ADS)

    Marsac, F.; Barlow, R.; Ternon, J. F.; Ménard, F.; Roberts, M.

    2014-02-01

    straightforward as adult tunas caught by longline have the ability to explore different foraging habitats over a broad range of depths. Several suggestions for advancing eddy-related research from the current state of knowledge are proposed in the second part of the paper.

  8. "Ames Research Center: Linking our Origins to our Future"

    NASA Technical Reports Server (NTRS)

    DesMarais, David J.

    2005-01-01

    Our research traces a path from interstellar materials to inhabited worlds and beyond. We examine how protoplanetary disks evolve and form terrestrial planets, the evolutionary paths of habitable planets, and how external factors (e.g., orbital eccentricity) and internal factors (atmospheric circulation) affect habitability. We trace, spectroscopically and chemically, the evolution of organic molecules from the interstellar medium onto habitable bodies. We examine how membranes might form under prebiotic planetary conditions. We evolve proteins capable of sustaining early metabolism, such as synthesis of biopolymers and transport of ions across membranes. We estimate the frequency of finding a functional prebiotic protein that formed spontaneously. We characterize the formation of diagnostic microbial biosignatures in rock-hosted ecosystems in ophiolite springs as an analog for subsurface life within our solar system, and photosynthetic microbial mats as biota that could be detected on extrasolar planets. We develop quantitative models that simulate energy relationships, biogeochemical cycling, trace gas exchange, and biodiversity. We examine the effects of climate variability on a vegetation-rich biosphere over intermediate time scales, using South American ecosystems as a model. We address natural transport of life beyond its planet of origin, such as on a meteorite, where survivors must withstand radiation, desiccation, and time in transit. We fly organisms and ecosystems in low Earth orbit to test their resistance to space. The Ames E&PO program disseminates these themes to national- and international-scale audiences through partnerships with the California Academy of Sciences, Yellow stone National Park, New York Hall of Science, and several K-14 educational organizations.

  9. The Quality-of-Life (QOL) Research Movement: Past, Present, and Future

    ERIC Educational Resources Information Center

    Sirgy, M. Joseph; Michalos, Alex C.; Ferriss, Abbott L.; Easterlin, Richard A.; Pavot, William; Patrick, Donald

    2006-01-01

    The purpose of this paper is to trace the history of the social indicators or quality-of-life (QOL) research movement up to today, forecast future developments, and pave the way for future growth. Broadly speaking, we tried to review historical antecedents from the point of view of different disciplines, with specialists in each discipline…

  10. Critical research needs for identifying future changes in Gulf coral reef ecosystems

    PubMed Central

    Feary, David A.; Burt, John A.; Bauman, Andrew G.; Al Hazeem, Shaker; Abdel-Moati, Mohamed A.; Al-Khalifa, Khalifa A.; Anderson, Donald M.; Amos, Carl; Baker, Andrew; Bartholomew, Aaron; Bento, Rita; Cavalcante, Geórgenes H.; Chen, Chaolun Allen; Coles, Steve L.; Dab, Koosha; Fowler, Ashley M.; George, David; Grandcourt, Edwin; Hill, Ross; John, David M.; Jones, David A.; Keshavmurthy, Shashank; Mahmoud, Huda; Moradi Och Tapeh, Mahdi; Mostafavi, Pargol Ghavam; Naser, Humood; Pichon, Michel; Purkis, Sam; Riegl, Bernhard; Samimi-Namin, Kaveh; Sheppard, Charles; Vajed Samiei, Jahangir; Voolstra, Christian R.; Wiedenmann, Joerg

    2014-01-01

    Expert opinion was assessed to identify current knowledge gaps in determining future changes in Arabian/ Persian Gulf (thereafter ‘Gulf’) coral reefs. Thirty-one participants submitted 71 research questions that were peer-assessed in terms of scientific importance (i.e., filled a knowledge gap and was a research priority) and efficiency in resource use (i.e., was highly feasible and ecologically broad). Ten research questions, in six major research areas, were highly important for both understanding Gulf coral reef ecosystems and also an efficient use of limited research resources. These questions mirrored global evaluations of the importance of understanding and evaluating biodiversity, determining the potential impacts of climate change, the role of anthropogenic impacts in structuring coral reef communities, and economically evaluating coral reef communities. These questions provide guidance for future research on coral reef ecosystems within the Gulf, and enhance the potential for assessment and management of future changes in this globally significant region. PMID:23643407

  11. Critical research needs for identifying future changes in Gulf coral reef ecosystems.

    PubMed

    Feary, David A; Burt, John A; Bauman, Andrew G; Al Hazeem, Shaker; Abdel-Moati, Mohamed A; Al-Khalifa, Khalifa A; Anderson, Donald M; Amos, Carl; Baker, Andrew; Bartholomew, Aaron; Bento, Rita; Cavalcante, Geórgenes H; Chen, Chaolun Allen; Coles, Steve L; Dab, Koosha; Fowler, Ashley M; George, David; Grandcourt, Edwin; Hill, Ross; John, David M; Jones, David A; Keshavmurthy, Shashank; Mahmoud, Huda; Moradi Och Tapeh, Mahdi; Mostafavi, Pargol Ghavam; Naser, Humood; Pichon, Michel; Purkis, Sam; Riegl, Bernhard; Samimi-Namin, Kaveh; Sheppard, Charles; Vajed Samiei, Jahangir; Voolstra, Christian R; Wiedenmann, Joerg

    2013-07-30

    Expert opinion was assessed to identify current knowledge gaps in determining future changes in Arabian/Persian Gulf (thereafter 'Gulf') coral reefs. Thirty-one participants submitted 71 research questions that were peer-assessed in terms of scientific importance (i.e., filled a knowledge gap and was a research priority) and efficiency in resource use (i.e., was highly feasible and ecologically broad). Ten research questions, in six major research areas, were highly important for both understanding Gulf coral reef ecosystems and also an efficient use of limited research resources. These questions mirrored global evaluations of the importance of understanding and evaluating biodiversity, determining the potential impacts of climate change, the role of anthropogenic impacts in structuring coral reef communities, and economically evaluating coral reef communities. These questions provide guidance for future research on coral reef ecosystems within the Gulf, and enhance the potential for assessment and management of future changes in this globally significant region. PMID:23643407

  12. Geography Should Not Be Destiny: Focusing HIV/AIDS Implementation Research and Programs on Microepidemics in US Neighborhoods

    PubMed Central

    Yolken, Annajane; Cutler, Blayne; Trooskin, Stacey; Wilson, Phill; Little, Susan; Mayer, Kenneth

    2014-01-01

    African Americans and Hispanics are disproportionately affected by the HIV/AIDS epidemic. Within the most heavily affected cities, a few neighborhoods account for a large share of new HIV infections. Addressing racial and economic disparities in HIV infection requires an implementation program and research agenda that assess the impact of HIV prevention interventions focused on increasing HIV testing, treatment, and retention in care in the most heavily affected neighborhoods in urban areas of the United States. Neighborhood-based implementation research should evaluate programs that focus on community mobilization, media campaigns, routine testing, linkage to and retention in care, and block-by-block outreach strategies. PMID:24716570

  13. The Impact of HIV/AIDS on Children and Young People: Reviewing Research Conducted and Distilling Implications for the Education Sector in Asia. Discussion Paper No. I

    ERIC Educational Resources Information Center

    Wijngaarden, Jan; Shaeffer, Sheldon

    2005-01-01

    This discussion paper evaluates the impact of HIV/AIDS on the education sector in the Asia Pacific region. It looks at the impact of the epidemic on children (aged 0-18) focusing on how the presence of HIV/AIDS in the household affects the education sector. Examples are summarized from research papers from inter-governmental agencies including…

  14. Mapping Future Research in Disabilities--Research Initiatives in Intellectual Disabilities in India: Report of a National Interdisciplinary Meeting

    ERIC Educational Resources Information Center

    Cohen, Libby; Brown, Roy I.

    2012-01-01

    A meeting organized under the auspices of the International Association for the Scientific Study of Intellectual Disabilities (IASSID) Academy on Education, Teaching and Research was held in March 2011 at the India International Centre in New Delhi, India, with the explicit purpose of helping establish a road map for future research in…

  15. ESP in Applied Linguistics: Refining Research Agenda Implications and Future Directions of Research on Second Language Reading.

    ERIC Educational Resources Information Center

    Carrell, Patricia L.

    1987-01-01

    Recent research has shown that effective second-language reading involves an interaction of the reader with the text. This interactive view has relevance for other areas of second-language processing, including listening comprehension, writing, and English for special purposes. Future research is needed in metacognition, relationships among…

  16. McDonnell Douglas Helicopter Company independent research and development: Preparing for the future

    NASA Technical Reports Server (NTRS)

    Haggerty, Allen C.

    1988-01-01

    During the 1970's and 80's, research has produced the technology that is seen in aircraft such as the LHX and future models. The technology is discussed that is reaching maturity and moving into the application stage of future programs. Technology is discussed in six major areas: advanced concepts, analysis techniques, structures, systems, simulation, and research and development facilities. The partnership of McDonnell Douglas Helicopter Co. and the government in developing these technologies is illustrated in several programs.

  17. Evidence-based approach to HIV/AIDS policy and research prioritization in the Islamic Republic of Iran.

    PubMed

    Feizzadeh, A; Nedjat, S; Asghari, S; Keshtkar, A; Heshmat, R; Setayesh, H; Majdzadeh, R

    2010-03-01

    In formulating the second national strategic plan for prevention of HIV/AIDS in the Islamic Republic of Iran a more evidence-based approach was needed. This paper reports on a systematic review of the local evidence about the determinants of HIV/AIDS transmission in 3 categories: poor knowledge and negative attitudes about HIV transmission; injection drug use; and sexual promiscuity. Of 93 reports reviewed, 53 met the inclusion criteria. Information about the prevalence and magnitude of effect for the 3 risk determinants at the national and regional level was scarce. Heterogeneity between studies, even in the same sub-population, was significant. An improved research base and better sharing of information are needed within countries of the Eastern Mediterranean Region. PMID:20795438

  18. Research on aided navigation based on terrain elevation matching and simulation

    NASA Astrophysics Data System (ADS)

    He, Yanping; Liu, Xinxue; Cai, Yanping; Zhu, Yu

    2016-01-01

    The matching function of terrain-aided navigation is not only related to the algorithm, also associated with the terrain characteristics of matching area. Aiming at terrain matching area selection and matching algorithm of the terrain height matching system, the method of terrain information entropy is put forward on the basis of statistical characteristics of the terrain roughness, signal-to-noise ratio, and then COR algorithm, MAD algorithm, MSD algorithm is adopted for real-time map and reference map matching, finally shows the simulation comparison of three kinds of matching algorithm. Result of simulation shows that among the index of matching accuracy and speed of three kinds of algorithm, COR algorithm possess fastest calculation speed and lowest precision, matching accuracy of MSD is slightly higher than MAD algorithm and calculation speed of MSD is placed in the middle, and the simulation results provide selection basis for terrain-aided inertial navigation.

  19. Identifying Key Priorities for Future Palliative Care Research Using an Innovative Analytic Approach

    PubMed Central

    Riffin, Catherine; Pillemer, Karl; Chen, Emily K.; Warmington, Marcus; Adelman, Ronald D.; Reid, M. C.

    2015-01-01

    Using an innovative approach, we identified research priorities in palliative care to guide future research initiatives. We searched 7databases (2005–2012) for review articles published on the topics of palliative and hospice–end-of-life care. The identified research recommendations (n = 648) fell into 2 distinct categories: (1) ways to improve methodological approaches and (2) specific topic areas in need of future study. The most commonly cited priority within the theme of methodological approaches was the need for enhanced rigor. Specific topics in need of future study included perspectives and needs of patients, relatives, and providers; underrepresented populations; decision-making; cost-effectiveness; provider education; spirituality; service use; and inter-disciplinary approaches to delivering palliative care. This review underscores the need for additional research on specific topics and methodologically rigorous research to inform health policy and practice. PMID:25393169

  20. AIDS vaccine research in Asia: needs and opportunities. Report from a UNAIDS/WHO/NIID meeting Tokyo, 28-30 October 1998.

    PubMed

    1999-07-30

    A meeting was organized by the Joint United Nations Programme on HIV/AIDS (UNAIDS), the World Health Organisation (WHO) and the Japanese National Institute of Infectious Diseases (NIID) with the following objectives: (i) to discuss public health and economic rationale to accelerate the development and evaluation of HIV vaccines suitable for use in Asia; (ii) to review ongoing preclinical HIV vaccine research in Asia; (iii) to review the Asian experience in conducting clinical trials of HIV candidate vaccines; (iv) to explore possibilities for international collaboration between countries in the region and with other countries and institutions; and (v) to discuss issues related to availability of future effective HIV vaccines. The meeting was attended by participants from Australia, China, France, Germany, India, Japan, Malaysia, Myanmar, South Korea, Thailand, United Kingdom, and the United States of America. The HIV epidemic in Asia is rapidly spreading and has already resulted in a total of 7 million HIV infections in the region. The epidemic already has a significant public health and economic impact, which may be worse in the future, unless effective intervention programmes are successfully implemented. A safe, effective, and affordable vaccine should be considered as the best hope for a long-term solution to the HIV epidemic in Asia. Asian scientists and institutions have established a number of international collaborations to isolate and characterize prevalent HIV-1 strains (mostly belonging to subtypes C and E) and are developing candidate vaccines based on these subtypes. In the region, phase I/II clinical trials of preventative HIV candidate vaccines have been conducted in Australia, China and Thailand. Since 1993, a comprehensive National AIDS Vaccine Plan has allowed Thailand to conduct phase I/II trials of six different preventative or therapeutic candidate vaccines, and the first phase III preventative efficacy trial has been approved. The meeting