Computer Aided Teaching of Digital Signal Processing.

ERIC Educational Resources Information Center

Castro, Ian P.

1990-01-01

Describes a microcomputer-based software package developed at the University of Surrey for teaching digital signal processing to undergraduate science and engineering students. Menu-driven software capabilities are explained, including demonstration of qualitative concepts and experimentation with quantitative data, and examples are given of…

A comparison between the first-fit settings of two multichannel digital signal-processing strategies: music quality ratings and speech-in-noise scores.

PubMed

Higgins, Paul; Searchfield, Grant; Coad, Gavin

2012-06-01

The aim of this study was to determine which level-dependent hearing aid digital signal-processing strategy (DSP) participants preferred when listening to music and/or performing a speech-in-noise task. Two receiver-in-the-ear hearing aids were compared: one using 32-channel adaptive dynamic range optimization (ADRO) and the other wide dynamic range compression (WDRC) incorporating dual fast (4 channel) and slow (15 channel) processing. The manufacturers' first-fit settings based on participants' audiograms were used in both cases. Results were obtained from 18 participants on a quick speech-in-noise (QuickSIN; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004) task and for 3 music listening conditions (classical, jazz, and rock). Participants preferred the quality of music and performed better at the QuickSIN task using the hearing aids with ADRO processing. A potential reason for the better performance of the ADRO hearing aids was less fluctuation in output with change in sound dynamics. ADRO processing has advantages for both music quality and speech recognition in noise over the multichannel WDRC processing that was used in the study. Further evaluations of which DSP aspects contribute to listener preference are required.

Comparison of multichannel wide dynamic range compression and ChannelFree processing in open canal hearing instruments.

PubMed

Plyler, Patrick N; Reber, Monika Bertges; Kovach, Amanda; Galloway, Elisabeth; Humphrey, Elizabeth

2013-02-01

Multichannel wide dynamic range compression (WDRC) and ChannelFree processing have similar goals yet differ significantly in terms of signal processing. Multichannel WDRC devices divide the input signal into separate frequency bands; a separate level is determined within each frequency band; and compression in each band is based on the level within each band. ChannelFree processing detects the wideband level, and gain adjustments are based on the wideband signal level and adjusted up to 20,000 times per second. Although both signal processing strategies are currently available in hearing aids, it is unclear if differences in these signal processing strategies affect the performance and/or preference of the end user. The purpose of the research was to determine the effects of multichannel wide dynamic range compression and ChannelFree processing on performance and/or preference of listeners using open-canal hearing instruments. An experimental study in which subjects were exposed to a repeated measures design was utilized. Fourteen adult listeners with mild sloping to moderately severe sensorineural hearing loss participated (mean age 67 yr). Participants completed two 5 wk trial periods for each signal processing strategy. Probe microphone, behavioral and subjective measures were conducted unaided and aided at the end of each trial period. Behavioral and subjective results for both signal processing strategies were significantly better than unaided results; however, behavioral and subjective results were not significantly different between the signal processing strategies. Multichannel WDRC and ChannelFree processing are both effective signal processing strategies that provide significant benefit for hearing instrument users. Overall preference between the strategies may be related to the degree of hearing loss of the user, high-frequency in-situ levels, and/or acceptance of background noise. American Academy of Audiology.

Working memory, age, and hearing loss: susceptibility to hearing aid distortion.

PubMed

Arehart, Kathryn H; Souza, Pamela; Baca, Rosalinda; Kates, James M

2013-01-01

Hearing aids use complex processing intended to improve speech recognition. Although many listeners benefit from such processing, it can also introduce distortion that offsets or cancels intended benefits for some individuals. The purpose of the present study was to determine the effects of cognitive ability (working memory) on individual listeners' responses to distortion caused by frequency compression applied to noisy speech. The present study analyzed a large data set of intelligibility scores for frequency-compressed speech presented in quiet and at a range of signal-to-babble ratios. The intelligibility data set was based on scores from 26 adults with hearing loss with ages ranging from 62 to 92 years. The listeners were grouped based on working memory ability. The amount of signal modification (distortion) caused by frequency compression and noise was measured using a sound quality metric. Analysis of variance and hierarchical linear modeling were used to identify meaningful differences between subject groups as a function of signal distortion caused by frequency compression and noise. Working memory was a significant factor in listeners' intelligibility of sentences presented in babble noise and processed with frequency compression based on sinusoidal modeling. At maximum signal modification (caused by both frequency compression and babble noise), the factor of working memory (when controlling for age and hearing loss) accounted for 29.3% of the variance in intelligibility scores. Combining working memory, age, and hearing loss accounted for a total of 47.5% of the variability in intelligibility scores. Furthermore, as the total amount of signal distortion increased, listeners with higher working memory performed better on the intelligibility task than listeners with lower working memory did. Working memory is a significant factor in listeners' responses to total signal distortion caused by cumulative effects of babble noise and frequency compression implemented with sinusoidal modeling. These results, together with other studies focused on wide-dynamic range compression, suggest that older listeners with hearing loss and poor working memory are more susceptible to distortions caused by at least some types of hearing aid signal-processing algorithms and by noise, and that this increased susceptibility should be considered in the hearing aid fitting process.

The effect of hearing aid technologies on listening in an automobile

PubMed Central

Wu, Yu-Hsiang; Stangl, Elizabeth; Bentler, Ruth A.; Stanziola, Rachel W.

2014-01-01

Background Communication while traveling in an automobile often is very difficult for hearing aid users. This is because the automobile /road noise level is usually high, and listeners/drivers often do not have access to visual cues. Since the talker of interest usually is not located in front of the driver/listener, conventional directional processing that places the directivity beam toward the listener’s front may not be helpful, and in fact, could have a negative impact on speech recognition (when compared to omnidirectional processing). Recently, technologies have become available in commercial hearing aids that are designed to improve speech recognition and/or listening effort in noisy conditions where talkers are located behind or beside the listener. These technologies include (1) a directional microphone system that uses a backward-facing directivity pattern (Back-DIR processing), (2) a technology that transmits audio signals from the ear with the better signal-to-noise ratio (SNR) to the ear with the poorer SNR (Side-Transmission processing), and (3) a signal processing scheme that suppresses the noise at the ear with the poorer SNR (Side-Suppression processing). Purpose The purpose of the current study was to determine the effect of (1) conventional directional microphones and (2) newer signal processing schemes (Back-DIR, Side-Transmission, and Side-Suppression) on listener’s speech recognition performance and preference for communication in a traveling automobile. Research design A single-blinded, repeated-measures design was used. Study Sample Twenty-five adults with bilateral symmetrical sensorineural hearing loss aged 44 through 84 years participated in the study. Data Collection and Analysis The automobile/road noise and sentences of the Connected Speech Test (CST) were recorded through hearing aids in a standard van moving at a speed of 70 miles/hour on a paved highway. The hearing aids were programmed to omnidirectional microphone, conventional adaptive directional microphone, and the three newer schemes. CST sentences were presented from the side and back of the hearing aids, which were placed on the ears of a manikin. The recorded stimuli were presented to listeners via earphones in a sound treated booth to assess speech recognition performance and preference with each programmed condition. Results Compared to omnidirectional microphones, conventional adaptive directional processing had a detrimental effect on speech recognition when speech was presented from the back or side of the listener. Back-DIR and Side-Transmission processing improved speech recognition performance (relative to both omnidirectional and adaptive directional processing) when speech was from the back and side, respectively. The performance with Side-Suppression processing was better than with adaptive directional processing when speech was from the side. The participants’ preferences for a given processing scheme were generally consistent with speech recognition results. Conclusions The finding that performance with adaptive directional processing was poorer than with omnidirectional microphones demonstrates the importance of selecting the correct microphone technology for different listening situations. The results also suggest the feasibility of using hearing aid technologies to provide a better listening experience for hearing aid users in automobiles. PMID:23886425

Prediction of the use of conventional hearing aids in Korean adults with unilateral hearing impairment.

PubMed

Lee, Dong-Hee; Noh, Heil

2015-01-01

To determine the use of a hearing aid at six months post-fitting and to evaluate the predictors of its ongoing use in Korean adults with unilateral hearing impairment (HI). Retrospective study at a secondary referral hospital over a 15-year period. This study analysed 119 adults with unilateral HI who had been recommended for hearing amplification (55 men and 64 women, mean age, 58.0 ± 11.7 years). Six months after the fitting, all of the participants were surveyed regarding subsequent decisions and actions about obtaining hearing aids. General uptake rate for a hearing aid was 68.1% (58.0% of participants surveyed were successful users, and 10.1% were intermittent users). The most significant parameter associated with hearing-aid use was social and/or work activities (R(2) = 0.457), and the significant predictors for successful hearing-aid use were social and/or work activities and method of signal processing (discriminatory power = 56.3%). Six months post-fitting, 68.1% of Korean adults with unilateral HI who had agreed to try a hearing aid continued to use it regularly. The predictors for hearing-aid use six months post-fitting included social and/or work activities and digital signal processing.

Cognitive Processing Speed, Working Memory, and the Intelligibility of Hearing Aid-Processed Speech in Persons with Hearing Impairment

PubMed Central

Yumba, Wycliffe Kabaywe

2017-01-01

Previous studies have demonstrated that successful listening with advanced signal processing in digital hearing aids is associated with individual cognitive capacity, particularly working memory capacity (WMC). This study aimed to examine the relationship between cognitive abilities (cognitive processing speed and WMC) and individual listeners’ responses to digital signal processing settings in adverse listening conditions. A total of 194 native Swedish speakers (83 women and 111 men), aged 33–80 years (mean = 60.75 years, SD = 8.89), with bilateral, symmetrical mild to moderate sensorineural hearing loss who had completed a lexical decision speed test (measuring cognitive processing speed) and semantic word-pair span test (SWPST, capturing WMC) participated in this study. The Hagerman test (capturing speech recognition in noise) was conducted using an experimental hearing aid with three digital signal processing settings: (1) linear amplification without noise reduction (NoP), (2) linear amplification with noise reduction (NR), and (3) non-linear amplification without NR (“fast-acting compression”). The results showed that cognitive processing speed was a better predictor of speech intelligibility in noise, regardless of the types of signal processing algorithms used. That is, there was a stronger association between cognitive processing speed and NR outcomes and fast-acting compression outcomes (in steady state noise). We observed a weaker relationship between working memory and NR, but WMC did not relate to fast-acting compression. WMC was a relatively weaker predictor of speech intelligibility in noise. These findings might have been different if the participants had been provided with training and or allowed to acclimatize to binary masking noise reduction or fast-acting compression. PMID:28861009

Biologically inspired binaural hearing aid algorithms: Design principles and effectiveness

NASA Astrophysics Data System (ADS)

Feng, Albert

2002-05-01

Despite rapid advances in the sophistication of hearing aid technology and microelectronics, listening in noise remains problematic for people with hearing impairment. To solve this problem two algorithms were designed for use in binaural hearing aid systems. The signal processing strategies are based on principles in auditory physiology and psychophysics: (a) the location/extraction (L/E) binaural computational scheme determines the directions of source locations and cancels noise by applying a simple subtraction method over every frequency band; and (b) the frequency-domain minimum-variance (FMV) scheme extracts a target sound from a known direction amidst multiple interfering sound sources. Both algorithms were evaluated using standard metrics such as signal-to-noise-ratio gain and articulation index. Results were compared with those from conventional adaptive beam-forming algorithms. In free-field tests with multiple interfering sound sources our algorithms performed better than conventional algorithms. Preliminary intelligibility and speech reception results in multitalker environments showed gains for every listener with normal or impaired hearing when the signals were processed in real time with the FMV binaural hearing aid algorithm. [Work supported by NIH-NIDCD Grant No. R21DC04840 and the Beckman Institute.

Intelligent hearing aids: the next revolution.

PubMed

Tao Zhang; Mustiere, Fred; Micheyl, Christophe

2016-08-01

The first revolution in hearing aids came from nonlinear amplification, which allows better compensation for both soft and loud sounds. The second revolution stemmed from the introduction of digital signal processing, which allows better programmability and more sophisticated algorithms. The third revolution in hearing aids is wireless, which allows seamless connectivity between a pair of hearing aids and with more and more external devices. Each revolution has fundamentally transformed hearing aids and pushed the entire industry forward significantly. Machine learning has received significant attention in recent years and has been applied in many other industries, e.g., robotics, speech recognition, genetics, and crowdsourcing. We argue that the next revolution in hearing aids is machine intelligence. In fact, this revolution is already quietly happening. We will review the development in at least three major areas: applications of machine learning in speech enhancement; applications of machine learning in individualization and customization of signal processing algorithms; applications of machine learning in improving the efficiency and effectiveness of clinical tests. With the advent of the internet of things, the above developments will accelerate. This revolution will bring patient satisfactions to a new level that has never been seen before.

Challenges and Recent Developments in Hearing Aids: Part II. Feedback and Occlusion Effect Reduction Strategies, Laser Shell Manufacturing Processes, and Other Signal Processing Technologies

PubMed Central

Chung, King

2004-01-01

This is the second part of a review on the challenges and recent developments in hearing aids. Feedback and the occlusion effect pose great challenges in hearing aid design and usage. Yet, conventional solutions to feedback and the occlusion effect often create a dilemma: the solution to one often leads to the other. This review discusses the advanced signal processing strategies to reduce feedback and some new approaches to reduce the occlusion effect. Specifically, the causes of three types of feedback (acoustic, mechanical, and electromagnetic) are discussed. The strategies currently used to reduce acoustic feedback (i.e., adaptive feedback reduction algorithms using adaptive gain reduction, notch filtering, and phase cancellation strategies) and the design of new receivers that are built to reduce mechanical and electromagnetic feedback are explained. In addition, various new strategies (i.e., redesigned sound delivery devices and receiver-in-the-ear-canal hearing aid configuration) to reduce the occlusion effect are reviewed. Many manufacturers have recently adopted laser shell-manufacturing technologies to overcome problems associated with manufacturing custom hearing aid shells. The mechanisms of selected laser sintering and stereo lithographic apparatus and the properties of custom shells produced by these two processes are reviewed. Further, various new developments in hearing aid transducers, telecoils, channel-free amplification, open-platform programming options, rechargeable hearing aids, ear-level frequency modulated (FM) receivers, wireless Bluetooth FM systems, and wireless programming options are briefly explained and discussed. Finally, the applications of advanced hearing aid technologies to enhance other devices such as cochlear implants, hearing protectors, and cellular phones are discussed. PMID:15735871

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

PubMed Central

Zhang, Sheng-Jia; Zou, Ming; Lu, Li; Lau, David; Ditzel, Désirée A. W.; Delucinge-Vivier, Celine; Aso, Yoshinori; Descombes, Patrick; Bading, Hilmar

2009-01-01

Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show that in hippocampal neurons nuclear calcium is one of the most potent signals in neuronal gene expression. The induction or repression of 185 neuronal activity-regulated genes is dependent upon nuclear calcium signaling. The nuclear calcium-regulated gene pool contains a genomic program that mediates synaptic activity-induced, acquired neuroprotection. The core set of neuroprotective genes consists of 9 principal components, termed Activity-regulated Inhibitor of Death (AID) genes, and includes Atf3, Btg2, GADD45β, GADD45γ, Inhibin β-A, Interferon activated gene 202B, Npas4, Nr4a1, and Serpinb2, which strongly promote survival of cultured hippocampal neurons. Several AID genes provide neuroprotection through a common process that renders mitochondria more resistant to cellular stress and toxic insults. Stereotaxic delivery of AID gene-expressing recombinant adeno-associated viruses to the hippocampus confers protection in vivo against seizure-induced brain damage. Thus, treatments that enhance nuclear calcium signaling or supplement AID genes represent novel therapies to combat neurodegenerative conditions and neuronal cell loss caused by synaptic dysfunction, which may be accompanied by a deregulation of calcium signal initiation and/or propagation to the cell nucleus. PMID:19680447

The mathematical theory of signal processing and compression-designs

NASA Astrophysics Data System (ADS)

Feria, Erlan H.

2006-05-01

The mathematical theory of signal processing, named processor coding, will be shown to inherently arise as the computational time dual of Shannon's mathematical theory of communication which is also known as source coding. Source coding is concerned with signal source memory space compression while processor coding deals with signal processor computational time compression. Their combination is named compression-designs and referred as Conde in short. A compelling and pedagogically appealing diagram will be discussed highlighting Conde's remarkable successful application to real-world knowledge-aided (KA) airborne moving target indicator (AMTI) radar.

[Nurses' perceptions of the vulnerabilities to STD/AIDS in light of the process of adolescence].

PubMed

Silva, Ítalo Rodolfo; Gomes, Antonio Marcos Tosoli; Valadares, Glaucia Valente; dos Santos, Nereida Lúcia Palko; da Silva, Thiago Privado; Leite, Joséte Luzia

2015-09-01

to understand the perception of nurses on the vulnerabilities to STD/AIDS in light of the process of adolescence. qualitative research conducted with 15 nurses in a centre for the studies of adolescent healthcare of a university hospital in Rio de Janeiro/Brazil. The adopted theoretical and methodological frameworks were the Complexity Theory and the Grounded Theory, respectively. The semi-structured interview was used to collect data from January to August 2012. this research presents the category: Nurses' perceptions of the vulnerabilities to STD/AIDS in light of the process of adolescence, and the subcategories: Risks and uncertainties of the process of adolescence: paths to STD/AIDS; Age-adolescence complex: expanding knowledge from the perception of nurses. once the nurses understand the complexity of adolescence, they create strategies to reduce the vulnerability of adolescents to STD/AIDS. This signals the need to invest in education, assistance and the management of nursing care for adolescents.

An Adaptive INS-Aided PLL Tracking Method for GNSS Receivers in Harsh Environments.

PubMed

Cong, Li; Li, Xin; Jin, Tian; Yue, Song; Xue, Rui

2016-01-23

As the weak link in global navigation satellite system (GNSS) signal processing, the phase-locked loop (PLL) is easily influenced with frequent cycle slips and loss of lock as a result of higher vehicle dynamics and lower signal-to-noise ratios. With inertial navigation system (INS) aid, PLLs' tracking performance can be improved. However, for harsh environments with high dynamics and signal attenuation, the traditional INS-aided PLL with fixed loop parameters has some limitations to improve the tracking adaptability. In this paper, an adaptive INS-aided PLL capable of adjusting its noise bandwidth and coherent integration time has been proposed. Through theoretical analysis, the relation between INS-aided PLL phase tracking error and carrier to noise density ratio (C/N₀), vehicle dynamics, aiding information update time, noise bandwidth, and coherent integration time has been built. The relation formulae are used to choose the optimal integration time and bandwidth for a given application under the minimum tracking error criterion. Software and hardware simulation results verify the correctness of the theoretical analysis, and demonstrate that the adaptive tracking method can effectively improve the PLL tracking ability and integrated GNSS/INS navigation performance. For harsh environments, the tracking sensitivity is increased by 3 to 5 dB, velocity errors are decreased by 36% to 50% and position errors are decreased by 6% to 24% when compared with other INS-aided PLL methods.

Electronic filters, hearing aids and methods

NASA Technical Reports Server (NTRS)

Engebretson, A. Maynard (Inventor)

1995-01-01

An electronic filter for an electroacoustic system. The system has a microphone for generating an electrical output from external sounds and an electrically driven transducer for emitting sound. Some of the sound emitted by the transducer returns to the microphone means to add a feedback contribution to its electrical output. The electronic filter includes a first circuit for electronic processing of the electrical output of the microphone to produce a first signal. An adaptive filter, interconnected with the first circuit, performs electronic processing of the first signal to produce an adaptive output to the first circuit to substantially offset the feedback contribution in the electrical output of the microphone, and the adaptive filter includes means for adapting only in response to polarities of signals supplied to and from the first circuit. Other electronic filters for hearing aids, public address systems and other electroacoustic systems, as well as such systems and methods of operating them are also disclosed.

Electronic filters, hearing aids and methods

NASA Technical Reports Server (NTRS)

Engebretson, A. Maynard (Inventor); O'Connell, Michael P. (Inventor); Zheng, Baohua (Inventor)

1991-01-01

An electronic filter for an electroacoustic system. The system has a microphone for generating an electrical output from external sounds and an electrically driven transducer for emitting sound. Some of the sound emitted by the transducer returns to the microphone means to add a feedback contribution to its electical output. The electronic filter includes a first circuit for electronic processing of the electrical output of the microphone to produce a filtered signal. An adaptive filter, interconnected with the first circuit, performs electronic processing of the filtered signal to produce an adaptive output to the first circuit to substantially offset the feedback contribution in the electrical output of the microphone, and the adaptive filter includes means for adapting only in response to polarities of signals supplied to and from the first circuit. Other electronic filters for hearing aids, public address systems and other electroacoustic systems, as well as such systems, and methods of operating them are also disclosed.

An Evaluation of Frequency Transposition for Hearing-Impaired School-Age Children

ERIC Educational Resources Information Center

Smith, Jenny; Dann, Marilyn; Brown, P. Margaret

2009-01-01

A key objective when fitting hearing aids to children is to maximize the audibility of high frequency speech cues which are critical in the understanding of spoken English. Recent advances in digital signal processing have enabled the development of hearing aids which offer linear frequency transposition as a new way of accessing these important…

Computer-aided auscultation learning system for nursing technique instruction.

PubMed

Hou, Chun-Ju; Chen, Yen-Ting; Hu, Ling-Chen; Chuang, Chih-Chieh; Chiu, Yu-Hsien; Tsai, Ming-Shih

2008-01-01

Pulmonary auscultation is a physical assessment skill learned by nursing students for examining the respiratory system. Generally, a sound simulator equipped mannequin is used to group teach auscultation techniques via classroom demonstration. However, nursing students cannot readily duplicate this learning environment for self-study. The advancement of electronic and digital signal processing technologies facilitates simulating this learning environment. This study aims to develop a computer-aided auscultation learning system for assisting teachers and nursing students in auscultation teaching and learning. This system provides teachers with signal recording and processing of lung sounds and immediate playback of lung sounds for students. A graphical user interface allows teachers to control the measuring device, draw lung sound waveforms, highlight lung sound segments of interest, and include descriptive text. Effects on learning lung sound auscultation were evaluated for verifying the feasibility of the system. Fifteen nursing students voluntarily participated in the repeated experiment. The results of a paired t test showed that auscultative abilities of the students were significantly improved by using the computer-aided auscultation learning system.

Functional description of signal processing in the Rogue GPS receiver

NASA Technical Reports Server (NTRS)

Thomas, J. B.

1988-01-01

Over the past year, two Rogue GPS prototype receivers have been assembled and successfully subjected to a variety of laboratory and field tests. A functional description is presented of signal processing in the Rogue receiver, tracing the signal from RF input to the output values of group delay, phase, and data bits. The receiver can track up to eight satellites, without time multiplexing among satellites or channels, simultaneously measuring both group delay and phase for each of three channels (L1-C/A, L1-P, L2-P). The Rogue signal processing described requires generation of the code for all three channels. Receiver functional design, which emphasized accuracy, reliability, flexibility, and dynamic capability, is summarized. A detailed functional description of signal processing is presented, including C/A-channel and P-channel processing, carrier-aided averaging of group delays, checks for cycle slips, acquistion, and distinctive features.

33 CFR 62.47 - Sound signals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Sound signals. 62.47 Section 62... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.47 Sound signals. (a) Often sound signals are located on or adjacent to aids to navigation. When visual signals are obscured...

33 CFR 62.47 - Sound signals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sound signals. 62.47 Section 62... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.47 Sound signals. (a) Often sound signals are located on or adjacent to aids to navigation. When visual signals are obscured...

33 CFR 62.47 - Sound signals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Sound signals. 62.47 Section 62... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.47 Sound signals. (a) Often sound signals are located on or adjacent to aids to navigation. When visual signals are obscured...

33 CFR 62.47 - Sound signals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Sound signals. 62.47 Section 62... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.47 Sound signals. (a) Often sound signals are located on or adjacent to aids to navigation. When visual signals are obscured...

33 CFR 62.47 - Sound signals.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sound signals. 62.47 Section 62... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.47 Sound signals. (a) Often sound signals are located on or adjacent to aids to navigation. When visual signals are obscured...

Activation-induced cytidine deaminase (AID) is necessary for the epithelial–mesenchymal transition in mammary epithelial cells

PubMed Central

Muñoz, Denise P.; Lee, Elbert L.; Takayama, Sachiko; Coppé, Jean-Philippe; Heo, Seok-Jin; Boffelli, Dario; Di Noia, Javier M.; Martin, David I. K.

2013-01-01

Activation-induced cytidine deaminase (AID), which functions in antibody diversification, is also expressed in a variety of germ and somatic cells. Evidence that AID promotes DNA demethylation in epigenetic reprogramming phenomena, and that it is induced by inflammatory signals, led us to investigate its role in the epithelial–mesenchymal transition (EMT), a critical process in normal morphogenesis and tumor metastasis. We find that expression of AID is induced by inflammatory signals that induce the EMT in nontransformed mammary epithelial cells and in ZR75.1 breast cancer cells. shRNA–mediated knockdown of AID blocks induction of the EMT and prevents cells from acquiring invasive properties. Knockdown of AID suppresses expression of several key EMT transcriptional regulators and is associated with increased methylation of CpG islands proximal to the promoters of these genes; furthermore, the DNA demethylating agent 5 aza-2'deoxycytidine (5-Aza-dC) antagonizes the effects of AID knockdown on the expression of EMT factors. We conclude that AID is necessary for the EMT in this breast cancer cell model and in nontransformed mammary epithelial cells. Our results suggest that AID may act near the apex of a hierarchy of regulatory steps that drive the EMT, and are consistent with this effect being mediated by cytosine demethylation. This evidence links our findings to other reports of a role for AID in epigenetic reprogramming and control of gene expression. PMID:23882083

Dynamic relation between working memory capacity and speech recognition in noise during the first 6 months of hearing aid use.

PubMed

Ng, Elaine H N; Classon, Elisabet; Larsby, Birgitta; Arlinger, Stig; Lunner, Thomas; Rudner, Mary; Rönnberg, Jerker

2014-11-23

The present study aimed to investigate the changing relationship between aided speech recognition and cognitive function during the first 6 months of hearing aid use. Twenty-seven first-time hearing aid users with symmetrical mild to moderate sensorineural hearing loss were recruited. Aided speech recognition thresholds in noise were obtained in the hearing aid fitting session as well as at 3 and 6 months postfitting. Cognitive abilities were assessed using a reading span test, which is a measure of working memory capacity, and a cognitive test battery. Results showed a significant correlation between reading span and speech reception threshold during the hearing aid fitting session. This relation was significantly weakened over the first 6 months of hearing aid use. Multiple regression analysis showed that reading span was the main predictor of speech recognition thresholds in noise when hearing aids were first fitted, but that the pure-tone average hearing threshold was the main predictor 6 months later. One way of explaining the results is that working memory capacity plays a more important role in speech recognition in noise initially rather than after 6 months of use. We propose that new hearing aid users engage working memory capacity to recognize unfamiliar processed speech signals because the phonological form of these signals cannot be automatically matched to phonological representations in long-term memory. As familiarization proceeds, the mismatch effect is alleviated, and the engagement of working memory capacity is reduced. © The Author(s) 2014.

Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level

PubMed Central

Billings, Curtis J.; Miller, Christi W.; Tremblay, Kelly L.

2016-01-01

Purpose This study investigated (a) the effect of amplification on cortical auditory evoked potentials (CAEPs) at different signal levels when signal-to-noise ratios (SNRs) were equated between unaided and aided conditions, and (b) the effect of absolute signal level on aided CAEPs when SNR was held constant. Method CAEPs were recorded from 13 young adults with normal hearing. A 1000-Hz pure tone was presented in unaided and aided conditions with a linear analog hearing aid. Direct audio input was used, allowing recorded hearing aid noise floor to be added to unaided conditions to equate SNRs between conditions. An additional stimulus was created through scaling the noise floor to study the effect of signal level. Results Amplification resulted in delayed N1 and P2 peak latencies relative to the unaided condition. An effect of absolute signal level (when SNR was constant) was present for aided CAEP area measures, such that larger area measures were found at higher levels. Conclusion Results of this study further demonstrate that factors in addition to SNR must also be considered before CAEPs can be used to clinically to measure aided thresholds. PMID:26953543

Signal processing for the profoundly deaf.

PubMed

Boothyroyd, A

1990-01-01

Profound deafness, defined here as a hearing loss in excess of 90 dB, is characterized by high thresholds, reduced hearing range in the intensity and frequency domains, and poor resolution in the frequency and time domains. The high thresholds call for hearing aids with unusually high gains or remote microphones that can be placed close to the signal source. The former option creates acoustic feedback problems for which digital signal processing may yet offer solutions. The latter option calls for carrier wave technology that is already available. The reduced frequency and intensity ranges would appear to call for frequency and/or amplitude compression. It might also be argued, however, that any attempts to compress the acoustic signal into the limited hearing range of the profoundly deaf will be counterproductive because of poor frequency and time resolution, especially when the signal is present in noise. In experiments with a 2-channel compression system, only 1 of 9 subjects showed an improvement of perception with the introduction of fast-release (20 ms) compression. The other 8 experienced no benefit or a slight deterioration of performance. These results support the concept of providing the profoundly deaf with simpler, rather than more complex, patterns, perhaps through the use of feature extraction hearing aids. Data from users of cochlear implants already employing feature extraction techniques also support this concept.

The effect of compression speed on intelligibility: simulated hearing-aid processing with and without original temporal fine structure information.

PubMed

Hopkins, Kathryn; King, Andrew; Moore, Brian C J

2012-09-01

Hearing aids use amplitude compression to compensate for the effects of loudness recruitment. The compression speed that gives the best speech intelligibility varies among individuals. Moore [(2008). Trends Amplif. 12, 300-315] suggested that an individual's sensitivity to temporal fine structure (TFS) information may affect which compression speed gives most benefit. This hypothesis was tested using normal-hearing listeners with a simulated hearing loss. Sentences in a competing talker background were processed using multi-channel fast or slow compression followed by a simulation of threshold elevation and loudness recruitment. Signals were either tone vocoded with 1-ERB(N)-wide channels (where ERB(N) is the bandwidth of normal auditory filters) to remove the original TFS information, or not processed further. In a second experiment, signals were vocoded with either 1 - or 2-ERB(N)-wide channels, to test whether the available spectral detail affects the optimal compression speed. Intelligibility was significantly better for fast than slow compression regardless of vocoder channel bandwidth. The results suggest that the availability of original TFS or detailed spectral information does not affect the optimal compression speed. This conclusion is tentative, since while the vocoder processing removed the original TFS information, listeners may have used the altered TFS in the vocoded signals.

Computational intelligence for target assessment in Parkinson's disease

NASA Astrophysics Data System (ADS)

Micheli-Tzanakou, Evangelia; Hamilton, J. L.; Zheng, J.; Lehman, Richard M.

2001-11-01

Recent advances in image and signal processing have created a new challenging environment for biomedical engineers. Methods that were developed for different fields are now finding a fertile ground in biomedicine, especially in the analysis of bio-signals and in the understanding of images. More and more, these methods are used in the operating room, helping surgeons, and in the physician's office as aids for diagnostic purposes. Neural Network (NN) research on the other hand, has gone a long way in the past decade. NNs now consist of many thousands of highly interconnected processing elements that can encode, store and recall relationships between different patterns by altering the weighting coefficients of inputs in a systematic way. Although they can generate reasonable outputs from unknown input patterns, and can tolerate a great deal of noise, they are very slow when run on a serial machine. We have used advanced signal processing and innovative image processing methods that are used along with computational intelligence for diagnostic purposes and as visualization aids inside and outside the operating room. Applications to be discussed include EEGs and field potentials in Parkinson's disease along with 3D reconstruction of MR or fMR brain images in Parkinson's patients, are currently used in the operating room for Pallidotomies and Deep Brain Stimulation (DBS).

Electronic filters, signal conversion apparatus, hearing aids and methods

NASA Technical Reports Server (NTRS)

Morley, Jr., Robert E. (Inventor); Engebretson, A. Maynard (Inventor); Engel, George L. (Inventor); Sullivan, Thomas J. (Inventor)

1992-01-01

An electronic filter for filtering an electrical signal. Signal processing circuitry therein includes a logarithmic filter having a series of filter stages with inputs and outputs in cascade and respective circuits as GOVERNMENT SUPPORT This invention was made with U.S. Government support under Veterans Administration Contract VA KV 674P857 and National Aeronautics and Space Administration (NASA) Research Grant No. NAG10-0040. The U.S. Government has certain rights in this invention.

A design study of a signal detection system. [for search of extraterrestrial radio sources

NASA Technical Reports Server (NTRS)

Healy, T. J.

1980-01-01

A system is described which can aid in the search for radio signals from extraterrestrial sources, or in other applications characterized by low signal-to-noise ratios and very high data rates. The system follows a multichannel (16 million bin) spectrum analyzer, and has critical processing, system control, and memory fuctions. The design includes a moderately rich set of algorithms to be used in parallel to detect signals of unknown form. A multi-threshold approach is used to obtain high and low signal sensitivities. Relatively compact and transportable memory systems are specified.

Challenges and Recent Developments in Hearing Aids: Part I. Speech Understanding in Noise, Microphone Technologies and Noise Reduction Algorithms

PubMed Central

Chung, King

2004-01-01

This review discusses the challenges in hearing aid design and fitting and the recent developments in advanced signal processing technologies to meet these challenges. The first part of the review discusses the basic concepts and the building blocks of digital signal processing algorithms, namely, the signal detection and analysis unit, the decision rules, and the time constants involved in the execution of the decision. In addition, mechanisms and the differences in the implementation of various strategies used to reduce the negative effects of noise are discussed. These technologies include the microphone technologies that take advantage of the spatial differences between speech and noise and the noise reduction algorithms that take advantage of the spectral difference and temporal separation between speech and noise. The specific technologies discussed in this paper include first-order directional microphones, adaptive directional microphones, second-order directional microphones, microphone matching algorithms, array microphones, multichannel adaptive noise reduction algorithms, and synchrony detection noise reduction algorithms. Verification data for these technologies, if available, are also summarized. PMID:15678225

Analysis of adventitious lung sounds originating from pulmonary tuberculosis.

PubMed

Becker, K W; Scheffer, C; Blanckenberg, M M; Diacon, A H

2013-01-01

Tuberculosis is a common and potentially deadly infectious disease, usually affecting the respiratory system and causing the sound properties of symptomatic infected lungs to differ from non-infected lungs. Auscultation is often ruled out as a reliable diagnostic technique for TB due to the random distribution of the infection and the varying severity of damage to the lungs. However, advancements in signal processing techniques for respiratory sounds can improve the potential of auscultation far beyond the capabilities of the conventional mechanical stethoscope. Though computer-based signal analysis of respiratory sounds has produced a significant body of research, there have not been any recent investigations into the computer-aided analysis of lung sounds associated with pulmonary Tuberculosis (TB), despite the severity of the disease in many countries. In this paper, respiratory sounds were recorded from 14 locations around the posterior and anterior chest walls of healthy volunteers and patients infected with pulmonary TB. The most significant signal features in both the time and frequency domains associated with the presence of TB, were identified by using the statistical overlap factor (SOF). These features were then employed to train a neural network to automatically classify the auscultation recordings into their respective healthy or TB-origin categories. The neural network yielded a diagnostic accuracy of 73%, but it is believed that automated filtering of the noise in the clinics, more training samples and perhaps other signal processing methods can improve the results of future studies. This work demonstrates the potential of computer-aided auscultation as an aid for the diagnosis and treatment of TB.

The effect of multi-channel wide dynamic range compression, noise reduction, and the directional microphone on horizontal localization performance in hearing aid wearers.

PubMed

Keidser, Gitte; Rohrseitz, Kristin; Dillon, Harvey; Hamacher, Volkmar; Carter, Lyndal; Rass, Uwe; Convery, Elizabeth

2006-10-01

This study examined the effect that signal processing strategies used in modern hearing aids, such as multi-channel WDRC, noise reduction, and directional microphones have on interaural difference cues and horizontal localization performance relative to linear, time-invariant amplification. Twelve participants were bilaterally fitted with BTE devices. Horizontal localization testing using a 360 degrees loudspeaker array and broadband pulsed pink noise was performed two weeks, and two months, post-fitting. The effect of noise reduction was measured with a constant noise present at 80 degrees azimuth. Data were analysed independently in the left/right and front/back dimension and showed that of the three signal processing strategies, directional microphones had the most significant effect on horizontal localization performance and over time. Specifically, a cardioid microphone could decrease front/back errors over time, whereas left/right errors increased when different microphones were fitted to left and right ears. Front/back confusions were generally prominent. Objective measurements of interaural differences on KEMAR explained significant shifts in left/right errors. In conclusion, there is scope for improving the sense of localization in hearing aid users.

Use of Mueller and non-Mueller matrices to describe polarization properties of telescope-based polarimeters

NASA Astrophysics Data System (ADS)

Seagraves, P. H.; Elmore, David F.

1994-09-01

Systems using optical elements such as linear polarizers, retarders, and mirrors can be represented by Mueller matrices. Some polarimeters include elements with time-varying polarization properties, multiple light beams, light detectors, and signal processing equipment. Standard Mueller matrix forms describing time-varying retarders, and beam splitters are presented, as well as non-Mueller matrices which describe detection and signal processing. These matrices provide a compact and intuitive mathematical description of polarimeter response which can aid in the refining of instrument designs.

Computer-aided diagnosis of alcoholism-related EEG signals.

PubMed

Acharya, U Rajendra; S, Vidya; Bhat, Shreya; Adeli, Hojjat; Adeli, Amir

2014-12-01

Alcoholism is a severe disorder that affects the functionality of neurons in the central nervous system (CNS) and alters the behavior of the affected person. Electroencephalogram (EEG) signals can be used as a diagnostic tool in the evaluation of subjects with alcoholism. The neurophysiological interpretation of EEG signals in persons with alcoholism (PWA) is based on observation and interpretation of the frequency and power in their EEGs compared to EEG signals from persons without alcoholism. This paper presents a review of the known features of EEGs obtained from PWA and proposes that the impact of alcoholism on the brain can be determined by computer-aided analysis of EEGs through extracting the minute variations in the EEG signals that can differentiate the EEGs of PWA from those of nonaffected persons. The authors advance the idea of automated computer-aided diagnosis (CAD) of alcoholism by employing the EEG signals. This is achieved through judicious combination of signal processing techniques such as wavelet, nonlinear dynamics, and chaos theory and pattern recognition and classification techniques. A CAD system is cost-effective and efficient and can be used as a decision support system by physicians in the diagnosis and treatment of alcoholism especially those who do not specialize in alcoholism or neurophysiology. It can also be of great value to rehabilitation centers to assess PWA over time and to monitor the impact of treatment aimed at minimizing or reversing the effects of the disease on the brain. A CAD system can be used to determine the extent of alcoholism-related changes in EEG signals (low, medium, high) and the effectiveness of therapeutic plans. Copyright © 2014 Elsevier Inc. All rights reserved.

Very Large Scale Integrated Circuits for Military Systems.

DTIC Science & Technology

1981-01-01

ABBREVIATIONS A/D Analog-to-digital C AGC Automatic Gain Control A A/J Anti-jam ASP Advanced Signal Processor AU Arithmetic Units C.AD Computer-Aided...ESM) equipments (Ref. 23); in lieu of an adequate automatic proces- sing capability, the function is now performed manually (Ref. 24), which involves...a human operator, displays, etc., and a sacrifice in performance (acquisition speed, saturation signal density). Various automatic processing

Battlefield decision aid for acoustical ground sensors with interface to meteorological data sources

NASA Astrophysics Data System (ADS)

Wilson, D. Keith; Noble, John M.; VanAartsen, Bruce H.; Szeto, Gregory L.

2001-08-01

The performance of acoustical ground sensors depends heavily on the local atmospheric and terrain conditions. This paper describes a prototype physics-based decision aid, called the Acoustic Battlefield Aid (ABFA), for predicting these environ-mental effects. ABFA integrates advanced models for acoustic propagation, atmospheric structure, and array signal process-ing into a convenient graphical user interface. The propagation calculations are performed in the frequency domain on user-definable target spectra. The solution method involves a parabolic approximation to the wave equation combined with a ter-rain diffraction model. Sensor performance is characterized with Cramer-Rao lower bounds (CRLBs). The CRLB calcula-tions include randomization of signal energy and wavefront orientation resulting from atmospheric turbulence. Available performance characterizations include signal-to-noise ratio, probability of detection, direction-finding accuracy for isolated receiving arrays, and location-finding accuracy for networked receiving arrays. A suite of integrated tools allows users to create new target descriptions from standard digitized audio files and to design new sensor array layouts. These tools option-ally interface with the ARL Database/Automatic Target Recognition (ATR) Laboratory, providing access to an extensive library of target signatures. ABFA also includes a Java-based capability for network access of near real-time data from sur-face weather stations or forecasts from the Army's Integrated Meteorological System. As an example, the detection footprint of an acoustical sensor, as it evolves over a 13-hour period, is calculated.

75 FR 1799 - Terminate Long Range Aids to Navigation (Loran-C) Signal

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... to Navigation (Loran-C) Signal AGENCY: U.S. Coast Guard, DHS. ACTION: Notice; correction. SUMMARY... 998). The document announced termination of the Long Range Aids to Navigation (Loran-C) Signal...

Some characteristics of amplified music through hearing aids.

PubMed

Chasin, Marshall; Hockley, Neil S

2014-02-01

Hearing aids are a relatively non-invasive means of reducing the negative effects of hearing loss on an individual who does not require a cochlear implant. Music amplified through hearing aids has some interesting characteristics but high fidelity is not typically one of them. This poses a serious problem for the investigator who wants to perform research on music with hearing impaired individuals who wear hearing aids. If the signal at the tympanic membrane is somewhat distorted then this has consequences for the assessment of music processing when examining both the peripheral and the central auditory system. In this review article on the subject of hearing aids and music, some of the acoustical differences between speech and music will be described. Following this, a discussion about what hearing aids do well and also less well for music as an input will be presented. Finally, some recommendations are made about what can be done for hearing-impaired individuals who wear hearing aids to listen to music. Copyright © 2013 Elsevier B.V. All rights reserved.

Flight results from a study of aided inertial navigation applied to landing operations

NASA Technical Reports Server (NTRS)

Mcgee, L. A.; Smith, G. L.; Hegarty, D. M.; Carson, T. M.; Merrick, R. B.; Schmidt, S. F.; Conrad, B.

1973-01-01

An evaluation is presented of the approach and landing performance of a Kalman filter aided inertial navigation system using flight data obtained from a series of approaches and landings of the CV-340 aircraft at an instrumented test area. A description of the flight test is given, in which data recorded included: (1) accelerometer signals from the platform of an INS; (2) three ranges from the Ames-Cubic Precision Ranging System; and (3) radar and barometric altimeter signals. The method of system evaluation employed was postflight processing of the recorded data using a Kalman filter which was designed for use on the XDS920 computer onboard the CV-340 aircraft. Results shown include comparisons between the trajectories as estimated by the Kalman filter aided system and as determined from cinetheodolite data. Data start initialization of the Kalman filter, operation at a practical data rate, postflight modeling of sensor errors and operation under the adverse condition of bad data are illustrated.

Hearing aids: indications, technology, adaptation, and quality control

PubMed Central

Hoppe, Ulrich; Hesse, Gerhard

2017-01-01

Hearing loss can be caused by a number of different pathological conditions. Some of them can be successfully treated, mainly by surgery, depending on the individual’s disease process. However, the treatment of chronic sensorineural hearing loss with damaged cochlear structures usually needs hearing rehabilitation by means of technical amplification. During the last two decades tremendous improvements in hearing aid technology led to a higher quality of the hearing rehabilitation process. For example, due to sophisticated signal processing acoustic feedback could be reduced and hence open fitting options are available even for more subjects with higher degrees of hearing loss. In particular for high-frequency hearing loss, the use of open fitting is an option. Both the users’ acceptance and the perceived sound quality were significantly increased by open fittings. However, we are still faced with a low level of readiness in many hearing impaired subjects to accept acoustic amplification. Since ENT specialists play a key-role in hearing aid provision, they should promote early hearing aid rehabilitation and include this in the counselling even in subjects with mild and moderate hearing loss. Recent investigations demonstrated the benefit of early hearing aid use in this group of patients since this may help to reduce subsequent damages as auditory deprivation, social isolation, development of dementia, and cognitive decline. For subjects with tinnitus, hearing aids may also support masking by environmental sounds and enhance cortical inhibition. The present paper describes the latest developments of hearing aid technology and the current state of the art for amplification modalities. Implications for both hearing aid indication and provision are discussed. PMID:29279726

[The sources of inorganic sulfur in the process of cluster protein Fnr[4Fe-4S]2+ reconstruction in Escherichia coli cells cultivated with NO-donating agents].

PubMed

Vasil'eva, S V; Strel'tsova, D A; Vlaskina, A V; Mikoian, V D; Vanin, A F

2012-01-01

Dinitrosyl iron complexes (DNICs) with thiol ligands--binuclear and mononuclear--inhibited aidB gene expression in E. coli cells. This process is due to the nitrosylation of the active center in iron-sulfur protein Fnr [4Fe-4S]2+ by low-molecular DNICs. The next step is transformation of the above DNICs into the DNICs with the thiol groups in the apo-form of Fnr protein. These nitrosylated proteins are characterized by the EPR signal with g perpendicular = 2.04 and g parallel 1 = 2,014. An addition of sulfur containing L-Cys or N-A-L-Cys as well as Na2S to the cells lead to the increasing in the aidB gene expression simultaneously with an appearance of the EPR signal with g perpendicular = 2.04 and g parallel = 2.02 as the characteristics of the DNICs with persulfide (R-S-S-) ligands. We suppose that the recovery of the aidB gene activity was due to the accumulation of inorganic sulfur in the cells and reconstruction of the active center in Fnr[4Fe-4S]2+. It appears that the above process is the function of L-cysteine-desulfurase protein which repaired the active center of Fnr[4Fe-4S]2+ protein using the sulfur from L-Cys or N-A-L-Cys after its deacetylation. On the other side the ions of inorganic sulfur being reacted with SH-groups led to the transformation of DNIC with thiol ligands into the persulfides. Na2S was the most potent activator of the aidB gene expression in our experiments.

Sounds perceived as annoying by hearing-aid users in their daily soundscape.

PubMed

Skagerstrand, Åsa; Stenfelt, Stefan; Arlinger, Stig; Wikström, Joel

2014-04-01

The noises in modern soundscapes continue to increase and are a major origin for annoyance. For a hearing-impaired person, a hearing aid is often beneficial, but noise and annoying sounds can result in non-use of the hearing aid, temporary or permanently. The purpose of this study was to identify annoying sounds in a daily soundscape for hearing-aid users. A diary was used to collect data where the participants answered four questions per day about annoying sounds in the daily soundscape over a two-week period. Sixty adult hearing-aid users. Of the 60 participants 91% experienced annoying sounds daily when using hearing aids. The annoying sound mentioned by most users, was verbal human sounds, followed by other daily sound sources categorized into 17 groups such as TV/radio, vehicles, and machine tools. When the hearing-aid users were grouped in relation to age, hearing loss, gender, hearing-aid experience, and type of signal processing used in their hearing aids, small and only few significant differences were found when comparing their experience of annoying sounds. The results indicate that hearing-aid users often experience annoying sounds and improved clinical fitting routines may reduce the problem.

Novel multireceiver communication systems configurations based on optimal estimation theory

NASA Technical Reports Server (NTRS)

Kumar, Rajendra

1992-01-01

A novel multireceiver configuration for carrier arraying and/or signal arraying is presented. The proposed configuration is obtained by formulating the carrier and/or signal arraying problem as an optimal estimation problem, and it consists of two stages. The first stage optimally estimates various phase processes received at different receivers with coupled phase-locked loops wherein the individual loops acquire and track their respective receivers' phase processes but are aided by each other in an optimal manner via LF error signals. The proposed configuration results in the minimization of the the effective radio loss at the combiner output, and thus maximization of energy per bit to noise power spectral density ratio is achieved. A novel adaptive algorithm for the estimator of the signal model parameters when these are not known a priori is also presented.

Naval sensor data database (NSDD)

NASA Astrophysics Data System (ADS)

Robertson, Candace J.; Tubridy, Lisa H.

1999-08-01

The Naval Sensor Data database (NSDD) is a multi-year effort to archive, catalogue, and disseminate data from all types of sensors to the mine warfare, signal and image processing, and sensor development communities. The purpose is to improve and accelerate research and technology. Providing performers with the data required to develop and validate improvements in hardware, simulation, and processing will foster advances in sensor and system performance. The NSDD will provide a centralized source of sensor data in its associated ground truth, which will support an improved understanding will be benefited in the areas of signal processing, computer-aided detection and classification, data compression, data fusion, and geo-referencing, as well as sensor and sensor system design.

Fabricating Atom-Sized Gaps by Field-Aided Atom Migration in Nanoscale Junctions

NASA Astrophysics Data System (ADS)

Liu, Ran; Bi, Jun-Jie; Xie, Zhen; Yin, Kaikai; Wang, Dunyou; Zhang, Guang-Ping; Xiang, Dong; Wang, Chuan-Kui; Li, Zong-Liang

2018-05-01

The gap sizes between electrodes generated by typical methods are generally much larger than the dimension of a common molecule when fabricating a single-molecule junction, which dramatically suppresses the yield of single-molecule junctions. Based on the ab initio calculations, we develop a strategy named the field-aided method to accurately fabricate an atomic-sized gap between gold nanoelectrodes. To understand the mechanism of this strategy, configuration evolutions of gold nanojunction in stretching and compressing processes are calculated. The numerical results show that, in the stretching process, the gold atoms bridged between two electrodes are likely to form atomic chains. More significantly, lattice vacant positions can be easily generated in stretching and compressing processes, which make field-aided gap generation possible. In field-aided atom migration (FAAM), the external field can exert driving force, enhance the initial energy of the system, and decrease the barrier in the migration path, which makes the atom migration feasible. Conductance and stretching and compressing forces, as measurable variables in stretching and compressing processes, present very useful signals for determining the time to perform FAAM. Following this desirable strategy, we successfully fabricate gold nanogaps with a dimension of 0.38 ±0.05 nm in the experiment, as our calculation simulates.

Quantitative assessment of commercial filter 'aids' for red-green colour defectives.

PubMed

Moreland, Jack D; Westland, Steven; Cheung, Vien; Dain, Steven J

2010-09-01

The claims made for 43 commercial filter 'aids', that they improve the colour discrimination of red-green colour defectives, are assessed for protanomaly and deuteranomaly by changes in the colour spacing of traffic signals (European Standard EN 1836:2005) and of the Farnsworth D15 test. Spectral transmittances of the 'aids' are measured and tristimulus values with and without 'aids' are computed using cone fundamentals and the spectral power distributions of either the D15 chips illuminated by CIE Illuminant C or of traffic signals. Chromaticities (l,s) are presented in cone excitation diagrams for protanomaly and deuteranomaly in terms of the relative excitation of their long (L), medium (M) and short (S) wavelength-sensitive cones. After correcting for non-uniform colour spacing in these diagrams, standard deviations parallel to the l and s axes are computed and enhancement factors E(l) and E(s) are derived as the ratio of 'aided' to 'unaided' standard deviations. Values of E(l) for traffic signals with most 'aids' are <1 and many do not meet the European signal detection standard. A few 'aids' have expansive E(l) factors but with inadequate utility: the largest being 1.2 for traffic signals and 1.3 for the D15 colours. Analyses, replicated for 19 'aids' from one manufacturer using 658 Munsell colours inside the D15 locus, yield E(l) factors within 1% of those found for the 16 D15 colours. © 2010 The Authors, Ophthalmic and Physiological Optics © 2010 The College of Optometrists.

Clinical study of a digital vs an analogue hearing aid.

PubMed

Bille, M; Jensen, A M; Kjaerbøl, E; Vesterager, V; Sibelle, P; Nielsen, H

1999-01-01

Digital signal processing in hearing instruments has brought new perspectives to the compensation of hearing impairment and may result in alleviation of the adverse effects of hearing problems. This study compares a commercially available digital signal processing hearing aid (HA) (Senso) with a modern analogue HA with programmable fitting (Logo). The HAs tested are identical in appearance and, in spite of a different mode of operation, the study design ensured blinding of the test subjects. Outcome parameters were: improvements in speech recognition score in noise (deltaSRSN) with the HAs; overall preference for HA; overall satisfaction; and various measures of HA performance evaluated by a self-assessment questionnaire. A total of 28 experienced HA users with sensorineural hearing impairment were included and 25 completed the trial. No significant differences were found in deltaSRSN between the two HAs. Eleven subjects indicated an overall preference for the digital HA, 10 preferred the analogue HA and 4 had no preference. Concerning overall satisfaction, 8 subjects rated the digital HA superior to the analogue one, whereas 7 indicated a superior rating for the analogue HA and 10 rated the HAs equal. Acceptability of noise from traffic was the only outcome parameter which gave a significant difference between the HAs in favour of the digital HA. It is concluded that there are no significant differences in outcome between the digital and analogue signal processing HAs tested by these experienced HA-users.

(Re)politicising and (re)positioning prevention: community mobilisations and AIDS prevention in the new AIDS era.

PubMed

Rolston, Imara Ajani

2016-07-01

An increasing focus on the relationship between AIDS prevalence and socio-economic inequality signals the need for a revaluation of the role of "politics" and "power" in AIDS prevention. This revaluation bears great significance when considering the future trajectories of the AIDS prevention efforts that target highly marginalised populations with high prevalence rates. An emphasis on intersecting forms of inequality has direct implications for the future of AIDS prevention practice. This study explores the experiences of participants, facilitators and local stakeholders applying the United Nations Development Programme (UNDP) Community Capacity Enhancement-Community Conversations (CCE-CC) approach to AIDS prevention in the Eastern Cape province of South Africa. It uses the political narrative analysis of life histories and semi-structured interviews as a means to interrogate the lived experiences of local actors participating in or influenced by this popularised form of community mobilisation used throughout sub-Saharan Africa. Findings suggest the need for a more explicit and intentional valuation for the intersection between the social and political determinants of health in programmes that use community mobilisation as prevention. They also signal a need to critically re-evaluate "community mobilisation" as an AIDS prevention tradition. Intersecting social and political power dynamics play a significant role in both opening up and constraining community mobilisation efforts. This paper proposes the need for a pedagogical turn to "deep organising" and "participatory forms of democracy", as a necessary frontier for programmes working with highly marginalised populations with high prevalence rates. Programmes need to more explicitly support, protect, and advocate for the ability of affected communities to engage in political processes, discourse and long-term organising.

Evidence for the contribution of a threshold retrieval process to semantic memory.

PubMed

Kempnich, Maria; Urquhart, Josephine A; O'Connor, Akira R; Moulin, Chris J A

2017-10-01

It is widely held that episodic retrieval can recruit two processes: a threshold context retrieval process (recollection) and a continuous signal strength process (familiarity). Conversely the processes recruited during semantic retrieval are less well specified. We developed a semantic task analogous to single-item episodic recognition to interrogate semantic recognition receiver-operating characteristics (ROCs) for a marker of a threshold retrieval process. We fitted observed ROC points to three signal detection models: two models typically used in episodic recognition (unequal variance and dual-process signal detection models) and a novel dual-process recollect-to-reject (DP-RR) signal detection model that allows a threshold recollection process to aid both target identification and lure rejection. Given the nature of most semantic questions, we anticipated the DP-RR model would best fit the semantic task data. Experiment 1 (506 participants) provided evidence for a threshold retrieval process in semantic memory, with overall best fits to the DP-RR model. Experiment 2 (316 participants) found within-subjects estimates of episodic and semantic threshold retrieval to be uncorrelated. Our findings add weight to the proposal that semantic and episodic memory are served by similar dual-process retrieval systems, though the relationship between the two threshold processes needs to be more fully elucidated.

A silicon avalanche photodiode detector circuit for Nd:YAG laser scattering

NASA Astrophysics Data System (ADS)

Hsieh, C.-L.; Haskovec, J.; Carlstrom, T. N.; Deboo, J. C.; Greenfield, C. M.; Snider, R. T.; Trost, P.

1990-06-01

A silicon avalanche photodiode with an internal gain of about 50 to 100 is used in a temperature controlled environment to measure the Nd:YAG laser Thomson scattered spectrum in the wavelength range from 700 to 1150 nm. A charge sensitive preamplifier was developed for minimizing the noise contribution from the detector electronics. Signal levels as low as 20 photoelectrons (S/N = 1) can be detected. Measurements show that both the signal and the variance of the signal vary linearly with the input light level over the range of interest, indicating Poisson statistics. The signal is processed using a 100 ns delay line and a differential amplifier which subtracts the low frequency background light component. The background signal is amplified with a computer controlled variable gain amplifier and is used for an estimate of the measurement error, calibration, and Z sub eff measurements of the plasma. The signal processing was analyzed using a theoretical model to aid the system design and establish the procedure for data error analysis.

Silicon avalanche photodiode detector circuit for Nd:YAG laser scattering

NASA Astrophysics Data System (ADS)

Hsieh, C. L.; Haskovec, J.; Carlstrom, T. N.; DeBoo, J. C.; Greenfield, C. M.; Snider, R. T.; Trost, P.

1990-10-01

A silicon avalanche photodiode with an internal gain of about 50 to 100 is used in a temperature-controlled environment to measure the Nd:YAG laser Thomson scattered spectrum in the wavelength range from 700 to 1150 nm. A charge-sensitive preamplifier has been developed for minimizing the noise contribution from the detector electronics. Signal levels as low as 20 photoelectrons (S/N=1) can be detected. Measurements show that both the signal and the variance of the signal vary linearly with the input light level over the range of interest, indicating Poisson statistics. The signal is processed using a 100 ns delay line and a differential amplifier which subtracts the low-frequency background light component. The background signal is amplified with a computer-controlled variable gain amplifier and is used for an estimate of the measurement error, calibration, and Zeff measurements of the plasma. The signal processing has been analyzed using a theoretical model to aid the system design and establish the procedure for data error analysis.

Automated diagnosis of congestive heart failure using dual tree complex wavelet transform and statistical features extracted from 2s of ECG signals.

PubMed

Sudarshan, Vidya K; Acharya, U Rajendra; Oh, Shu Lih; Adam, Muhammad; Tan, Jen Hong; Chua, Chua Kuang; Chua, Kok Poo; Tan, Ru San

2017-04-01

Identification of alarming features in the electrocardiogram (ECG) signal is extremely significant for the prediction of congestive heart failure (CHF). ECG signal analysis carried out using computer-aided techniques can speed up the diagnosis process and aid in the proper management of CHF patients. Therefore, in this work, dual tree complex wavelets transform (DTCWT)-based methodology is proposed for an automated identification of ECG signals exhibiting CHF from normal. In the experiment, we have performed a DTCWT on ECG segments of 2s duration up to six levels to obtain the coefficients. From these DTCWT coefficients, statistical features are extracted and ranked using Bhattacharyya, entropy, minimum redundancy maximum relevance (mRMR), receiver-operating characteristics (ROC), Wilcoxon, t-test and reliefF methods. Ranked features are subjected to k-nearest neighbor (KNN) and decision tree (DT) classifiers for automated differentiation of CHF and normal ECG signals. We have achieved 99.86% accuracy, 99.78% sensitivity and 99.94% specificity in the identification of CHF affected ECG signals using 45 features. The proposed method is able to detect CHF patients accurately using only 2s of ECG signal length and hence providing sufficient time for the clinicians to further investigate on the severity of CHF and treatments. Copyright © 2017 Elsevier Ltd. All rights reserved.

Large Signal Modeling and Analysis of the GaAs MESFET.

DTIC Science & Technology

1986-07-09

various dimensions and physical parameters. A powerful computer aided design system can be developed by automating the circuit element and parameter...circuit model of the GaAs MESFET to aid in the designs of microwave MESFET circuits. The circuit elements of this model are obtained either directly...34. -. ’ Abstract The purpose of this work is to develop a large signal signal lumped circuit model of the GaAs MESFET to aid In the designs of microwave MESFET

An Intrinsically Digital Amplification Scheme for Hearing Aids

NASA Astrophysics Data System (ADS)

Blamey, Peter J.; Macfarlane, David S.; Steele, Brenton R.

2005-12-01

Results for linear and wide-dynamic range compression were compared with a new 64-channel digital amplification strategy in three separate studies. The new strategy addresses the requirements of the hearing aid user with efficient computations on an open-platform digital signal processor (DSP). The new amplification strategy is not modeled on prior analog strategies like compression and linear amplification, but uses statistical analysis of the signal to optimize the output dynamic range in each frequency band independently. Using the open-platform DSP processor also provided the opportunity for blind trial comparisons of the different processing schemes in BTE and ITE devices of a high commercial standard. The speech perception scores and questionnaire results show that it is possible to provide improved audibility for sound in many narrow frequency bands while simultaneously improving comfort, speech intelligibility in noise, and sound quality.

Expanding Biosensing Abilities through Computer-Aided Design of Metabolic Pathways.

PubMed

Libis, Vincent; Delépine, Baudoin; Faulon, Jean-Loup

2016-10-21

Detection of chemical signals is critical for cells in nature as well as in synthetic biology, where they serve as inputs for designer circuits. Important progress has been made in the design of signal processing circuits triggering complex biological behaviors, but the range of small molecules recognized by sensors as inputs is limited. The ability to detect new molecules will increase the number of synthetic biology applications, but direct engineering of tailor-made sensors takes time. Here we describe a way to immediately expand the range of biologically detectable molecules by systematically designing metabolic pathways that transform nondetectable molecules into molecules for which sensors already exist. We leveraged computer-aided design to predict such sensing-enabling metabolic pathways, and we built several new whole-cell biosensors for molecules such as cocaine, parathion, hippuric acid, and nitroglycerin.

Image Processing and Computer Aided Diagnosis in Computed Tomography of the Breast

DTIC Science & Technology

2007-03-01

TERMS breast imaging, breast CT, scatter compensation, denoising, CAD , Cone-beam CT 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...clinical projection images. The CAD tool based on signal known exactly (SKE) scenario is under development. Task 6: Test and compare the...performances of the CAD developed in Task 5 applied to processed projection data from Task 1 with the CAD performance on the projection data without Bayesian

Data mining for water resource management part 2 - methods and approaches to solving contemporary problems

USGS Publications Warehouse

Roehl, Edwin A.; Conrads, Paul

2010-01-01

This is the second of two papers that describe how data mining can aid natural-resource managers with the difficult problem of controlling the interactions between hydrologic and man-made systems. Data mining is a new science that assists scientists in converting large databases into knowledge, and is uniquely able to leverage the large amounts of real-time, multivariate data now being collected for hydrologic systems. Part 1 gives a high-level overview of data mining, and describes several applications that have addressed major water resource issues in South Carolina. This Part 2 paper describes how various data mining methods are integrated to produce predictive models for controlling surface- and groundwater hydraulics and quality. The methods include: - signal processing to remove noise and decompose complex signals into simpler components; - time series clustering that optimally groups hundreds of signals into "classes" that behave similarly for data reduction and (or) divide-and-conquer problem solving; - classification which optimally matches new data to behavioral classes; - artificial neural networks which optimally fit multivariate data to create predictive models; - model response surface visualization that greatly aids in understanding data and physical processes; and, - decision support systems that integrate data, models, and graphics into a single package that is easy to use.

Signal enhancement based on complex curvelet transform and complementary ensemble empirical mode decomposition

NASA Astrophysics Data System (ADS)

Dong, Lieqian; Wang, Deying; Zhang, Yimeng; Zhou, Datong

2017-09-01

Signal enhancement is a necessary step in seismic data processing. In this paper we utilize the complementary ensemble empirical mode decomposition (CEEMD) and complex curvelet transform (CCT) methods to separate signal from random noise further to improve the signal to noise (S/N) ratio. Firstly, the original data with noise is decomposed into a series of intrinsic mode function (IMF) profiles with the aid of CEEMD. Then the IMFs with noise are transformed into CCT domain. By choosing different thresholds which are based on the noise level difference of each IMF profile, the noise in original data can be suppressed. Finally, we illustrate the effectiveness of the approach by simulated and field datasets.

Range Measurement as Practiced in the Deep Space Network

NASA Technical Reports Server (NTRS)

Berner, Jeff B.; Bryant, Scott H.; Kinman, Peter W.

2007-01-01

Range measurements are used to improve the trajectory models of spacecraft tracked by the Deep Space Network. The unique challenge of deep-space ranging is that the two-way delay is long, typically many minutes, and the signal-to-noise ratio is small. Accurate measurements are made under these circumstances by means of long correlations that incorporate Doppler rate-aiding. This processing is done with commercial digital signal processors, providing a flexibility in signal design that can accommodate both the traditional sequential ranging signal and pseudonoise range codes. Accurate range determination requires the calibration of the delay within the tracking station. Measurements with a standard deviation of 1 m have been made.

Telecoil-mode hearing aid compatibility performance requirements for wireless and cordless handsets: magnetic signal levels.

PubMed

Julstrom, Stephen; Kozma-Spytek, Linda; Isabelle, Scott

2011-09-01

In the development of the requirements for telecoil-compatible magnetic signal sources for wireless and cordless telephones to be specified in the American National Standards Institute (ANSI) C63.19 and ANSI/Telecommunications Industry Association-1083 compatibility standards, it became evident that additional data concerning in-the-field telecoil use and subjective preferences were needed. Primarily, the magnetic signal levels and, secondarily, the field orientations required for effective and comfortable telecoil use with wireless and cordless handsets needed further characterization. (A companion article addresses user signal-to-noise needs and preferences.) Test subjects used their own hearing aids, which were addressed with both a controlled acoustic speech source and a controlled magnetic speech source. Each subject's hearing aid was first measured to find the telecoil's magnetic field orientation for maximum response, and an appropriate large magnetic head-worn coil was selected to apply the magnetic signal. Subjects could control the strength of the magnetic signal, first to match the loudness of a reference acoustic signal and then to find their Most Comfortable Level (MCL). The subjective judgments were compared against objective in-ear probe tube level measurements. The 57 test subjects covered an age range of 22 to 79 yr, with a self-reported hearing loss duration of 12 to 72 yr. All had telecoils that they used for at least some telecommunications needs. The self-reported degree of hearing loss ranged from moderate to profound. A total of 69 hearing aids were surveyed for their telecoil orientation. A guided intake questionnaire yielded general background information for each subject. A custom-built test jig enabled hearing aid telecoil orientation within the aid to be determined. By comparing this observation with the in-use hearing aid position, the in-use orientation for each telecoil was determined. A custom-built test control box fed by prepared speech recordings from computer files enabled the tester to switch between acoustic and magnetic speech signals and to read and record the subject's selected magnetic level settings. The overwhelming majority of behind-the-ear aids tested exhibited in-use telecoil orientations that were substantially vertical. An insufficient number of participants used in-the-ear aids to be able to draw general conclusions concerning the telecoil orientations of this style aid. The subjects showed a generally consistent preference for telecoil speech levels that subjectively matched the level that they heard from 65 dB SPL acoustic speech. The magnetic level needed to achieve their MCL, however, varied over a 30 dB range. Producing the necessary magnetic field strengths from a wireless or cordless telephone's handset in an in-use vertical orientation is vital for compatibility with the vast majority of behind-the-ear aids. Due to the very wide range of preferred magnetic signal levels shown, only indirect conclusions can be drawn concerning required signal levels. The strong preference for a 65 dB SPL equivalent level can be combined with established standards addressing hearing aid performance to derive reasonable source level requirements. Greater consistency between in-the-field hearing aid telecoil and microphone sensitivity adjustments could yield improved results for some users. American Academy of Audiology.

Music and Hearing Aids

PubMed Central

Moore, Brian C. J.

2014-01-01

The signal processing and fitting methods used for hearing aids have mainly been designed to optimize the intelligibility of speech. Little attention has been paid to the effectiveness of hearing aids for listening to music. Perhaps as a consequence, many hearing-aid users complain that they are not satisfied with their hearing aids when listening to music. This issue inspired the Internet-based survey presented here. The survey was designed to identify the nature and prevalence of problems associated with listening to live and reproduced music with hearing aids. Responses from 523 hearing-aid users to 21 multiple-choice questions are presented and analyzed, and the relationships between responses to questions regarding music and questions concerned with information about the respondents, their hearing aids, and their hearing loss are described. Large proportions of the respondents reported that they found their hearing aids to be helpful for listening to both live and reproduced music, although less so for the former. The survey also identified problems such as distortion, acoustic feedback, insufficient or excessive gain, unbalanced frequency response, and reduced tone quality. The results indicate that the enjoyment of listening to music with hearing aids could be improved by an increase of the input and output dynamic range, extension of the low-frequency response, and improvement of feedback cancellation and automatic gain control systems. PMID:25361601

Music and hearing aids.

PubMed

Madsen, Sara M K; Moore, Brian C J

2014-10-31

The signal processing and fitting methods used for hearing aids have mainly been designed to optimize the intelligibility of speech. Little attention has been paid to the effectiveness of hearing aids for listening to music. Perhaps as a consequence, many hearing-aid users complain that they are not satisfied with their hearing aids when listening to music. This issue inspired the Internet-based survey presented here. The survey was designed to identify the nature and prevalence of problems associated with listening to live and reproduced music with hearing aids. Responses from 523 hearing-aid users to 21 multiple-choice questions are presented and analyzed, and the relationships between responses to questions regarding music and questions concerned with information about the respondents, their hearing aids, and their hearing loss are described. Large proportions of the respondents reported that they found their hearing aids to be helpful for listening to both live and reproduced music, although less so for the former. The survey also identified problems such as distortion, acoustic feedback, insufficient or excessive gain, unbalanced frequency response, and reduced tone quality. The results indicate that the enjoyment of listening to music with hearing aids could be improved by an increase of the input and output dynamic range, extension of the low-frequency response, and improvement of feedback cancellation and automatic gain control systems. © The Author(s) 2014.

The Magnitude Response Learning Tool for DSP Education: A Case Study

ERIC Educational Resources Information Center

Kulmer, Florian; Wurzer, Christian Gun; Geiger, Bernhard C.

2016-01-01

Many concepts in digital signal processing are intuitive, despite being mathematically challenging. The lecturer not only has to teach the complicated math but should also help students develop intuition about the concept. To aid the lecturer in this task, the Magnitude Response Learning Tool has been introduced, a computer-based learning game…

Weak signal detection: A discrete window of opportunity for achieving 'Vision 90:90:90'?

PubMed

Burman, Christopher J; Aphane, Marota; Delobelle, Peter

2016-01-01

UNAIDS' Vision 90:90:90 is a call to 'end AIDS'. Developing predictive foresight of the unpredictable changes that this journey will entail could contribute to the ambition of 'ending AIDS'. There are few opportunities for managing unpredictable changes. We introduce 'weak signal detection' as a potential opportunity to fill this void. Combining futures and complexity theory, we reflect on two pilot case studies that involved the Archetype Extraction technique and the SenseMaker(®) Collector(™) tool. Both the piloted techniques have the potentials to surface weak signals--but there is room for improvement. A management response to a complex weak signal requires pattern management, rather than an exclusive focus on behaviour management. Weak signal detection is a window of opportunity to improve resilience to unpredictable changes in the HIV/AIDS landscape that can both reduce the risk that emerges from the changes and increase the visibility of opportunities to exploit the unpredictable changes that could contribute to 'ending AIDS'.

A Metric for Reducing False Positives in the Computer-Aided Detection of Breast Cancer from Dynamic Contrast-Enhanced Magnetic Resonance Imaging Based Screening Examinations of High-Risk Women.

PubMed

Levman, Jacob E D; Gallego-Ortiz, Cristina; Warner, Ellen; Causer, Petrina; Martel, Anne L

2016-02-01

Magnetic resonance imaging (MRI)-enabled cancer screening has been shown to be a highly sensitive method for the early detection of breast cancer. Computer-aided detection systems have the potential to improve the screening process by standardizing radiologists to a high level of diagnostic accuracy. This retrospective study was approved by the institutional review board of Sunnybrook Health Sciences Centre. This study compares the performance of a proposed method for computer-aided detection (based on the second-order spatial derivative of the relative signal intensity) with the signal enhancement ratio (SER) on MRI-based breast screening examinations. Comparison is performed using receiver operating characteristic (ROC) curve analysis as well as free-response receiver operating characteristic (FROC) curve analysis. A modified computer-aided detection system combining the proposed approach with the SER method is also presented. The proposed method provides improvements in the rates of false positive markings over the SER method in the detection of breast cancer (as assessed by FROC analysis). The modified computer-aided detection system that incorporates both the proposed method and the SER method yields ROC results equal to that produced by SER while simultaneously providing improvements over the SER method in terms of false positives per noncancerous exam. The proposed method for identifying malignancies outperforms the SER method in terms of false positives on a challenging dataset containing many small lesions and may play a useful role in breast cancer screening by MRI as part of a computer-aided detection system.

The RF Probe: providing space situational awareness through broad-spectrum detection and characterization

NASA Astrophysics Data System (ADS)

Zenick, Raymond; Kohlhepp, Kimberly; Partch, Russell

2004-09-01

AeroAstro's patented RF Probe is a system designed to address the needs of spacecraft developers and operators interested in measuring and analyzing near-field RF emissions emanating from a nearby spacecraft of interest. The RF Probe consists of an intelligent spectrum analyzer with digital signal processing capabilities combined with a calibrated, wide-bandwidth antenna and RF front end that covers the 50 kHz to 18 GHz spectrum. It is capable of acquiring signal level and signal vector information, classifying signals, assessing the quality of a satellite"s transponders, and characterizing near-field electromagnetic emissions. The RF Probe is intended for either incorporation as part of a suite of spacecraft sensors, or as a stand-alone sensor on spacecraft or other platforms such as Unmanned Aerial Vehicles (UAVs). The RF Probe was initially conceived as a tool to detect and aid in diagnosis of malfunctions in a spacecraft of interest. However, the utility of the RF Probe goes far beyond this initial concept, spanning a wide range of military applications. Most importantly, the RF Probe can provide space situational awareness for critical on-orbit assets by detecting externally induced RF fields, aiding in protection against potentially devastating attacks.

Fractal dimension and nonlinear dynamical processes

NASA Astrophysics Data System (ADS)

McCarty, Robert C.; Lindley, John P.

1993-11-01

Mandelbrot, Falconer and others have demonstrated the existence of dimensionally invariant geometrical properties of non-linear dynamical processes known as fractals. Barnsley defines fractal geometry as an extension of classical geometry. Such an extension, however, is not mathematically trivial Of specific interest to those engaged in signal processing is the potential use of fractal geometry to facilitate the analysis of non-linear signal processes often referred to as non-linear time series. Fractal geometry has been used in the modeling of non- linear time series represented by radar signals in the presence of ground clutter or interference generated by spatially distributed reflections around the target or a radar system. It was recognized by Mandelbrot that the fractal geometries represented by man-made objects had different dimensions than the geometries of the familiar objects that abound in nature such as leaves, clouds, ferns, trees, etc. The invariant dimensional property of non-linear processes suggests that in the case of acoustic signals (active or passive) generated within a dispersive medium such as the ocean environment, there exists much rich structure that will aid in the detection and classification of various objects, man-made or natural, within the medium.

Estimation of the influence of tool wear on force signals: A finite element approach in AISI 1045 orthogonal cutting

NASA Astrophysics Data System (ADS)

Equeter, Lucas; Ducobu, François; Rivière-Lorphèvre, Edouard; Abouridouane, Mustapha; Klocke, Fritz; Dehombreux, Pierre

2018-05-01

Industrial concerns arise regarding the significant cost of cutting tools in machining process. In particular, their improper replacement policy can lead either to scraps, or to early tool replacements, which would waste fine tools. ISO 3685 provides the flank wear end-of-life criterion. Flank wear is also the nominal type of wear for longest tool lifetimes in optimal cutting conditions. Its consequences include bad surface roughness and dimensional discrepancies. In order to aid the replacement decision process, several tool condition monitoring techniques are suggested. Force signals were shown in the literature to be strongly linked with tools flank wear. It can therefore be assumed that force signals are highly relevant for monitoring the condition of cutting tools and providing decision-aid information in the framework of their maintenance and replacement. The objective of this work is to correlate tools flank wear with numerically computed force signals. The present work uses a Finite Element Model with a Coupled Eulerian-Lagrangian approach. The geometry of the tool is changed for different runs of the model, in order to obtain results that are specific to a certain level of wear. The model is assessed by comparison with experimental data gathered earlier on fresh tools. Using the model at constant cutting parameters, force signals under different tool wear states are computed and provide force signals for each studied tool geometry. These signals are qualitatively compared with relevant data from the literature. At this point, no quantitative comparison could be performed on worn tools because the reviewed literature failed to provide similar studies in this material, either numerical or experimental. Therefore, further development of this work should include experimental campaigns aiming at collecting cutting forces signals and assessing the numerical results that were achieved through this work.

Mini-Sosie high-resolution seismic method aids hazards studies

USGS Publications Warehouse

Stephenson, W.J.; Odum, J.; Shedlock, K.M.; Pratt, T.L.; Williams, R.A.

1992-01-01

The Mini-Sosie high-resolution seismic method has been effective in imaging shallow-structure and stratigraphic features that aid in seismic-hazard and neotectonic studies. The method is not an alternative to Vibroseis acquisition for large-scale studies. However, it has two major advantages over Vibroseis as it is being used by the USGS in its seismic-hazards program. First, the sources are extremely portable and can be used in both rural and urban environments. Second, the shifting-and-summation process during acquisition improves the signal-to-noise ratio and cancels out seismic noise sources such as cars and pedestrians. -from Authors

Motor imaginary-based brain-machine interface design using programmable logic controllers for the disabled.

PubMed

Jeyabalan, Vickneswaran; Samraj, Andrews; Loo, Chu Kiong

2010-10-01

Aiming at the implementation of brain-machine interfaces (BMI) for the aid of disabled people, this paper presents a system design for real-time communication between the BMI and programmable logic controllers (PLCs) to control an electrical actuator that could be used in devices to help the disabled. Motor imaginary signals extracted from the brain’s motor cortex using an electroencephalogram (EEG) were used as a control signal. The EEG signals were pre-processed by means of adaptive recursive band-pass filtrations (ARBF) and classified using simplified fuzzy adaptive resonance theory mapping (ARTMAP) in which the classified signals are then translated into control signals used for machine control via the PLC. A real-time test system was designed using MATLAB for signal processing, KEP-Ware V4 OLE for process control (OPC), a wireless local area network router, an Omron Sysmac CPM1 PLC and a 5 V/0.3A motor. This paper explains the signal processing techniques, the PLC's hardware configuration, OPC configuration and real-time data exchange between MATLAB and PLC using the MATLAB OPC toolbox. The test results indicate that the function of exchanging real-time data can be attained between the BMI and PLC through OPC server and proves that it is an effective and feasible method to be applied to devices such as wheelchairs or electronic equipment.

Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

PubMed Central

Kodgire, Prashant; Mukkawar, Priyanka; Ratnam, Sarayu; Martin, Terence E.

2013-01-01

Somatic hypermutation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene transcription. We previously proposed that AID may associate with the RNA polymerase II (Pol). Here, to determine aspects of the transcription process required for SHM, we knocked-in a transcription terminator into an Ig gene variable region in DT40 chicken B cell line. We found that the human β-globin terminator was an efficient inhibitor of downstream transcription in these cells. The terminator reduced mutations downstream of the poly(A) signal, suggesting that the process of transcription is essential for efficient SHM and that AID has better access to its target when Pol is in the elongating rather than terminating mode. Mutations upstream of the poly(A) site were almost doubled in the active terminator clones compared with an inactivated terminator, and this region showed more single-stranded DNA, indicating that Pol pausing assists SHM. Moreover, the nontranscribed DNA strand was the preferred SHM target upstream of the active terminator. Pol pausing during poly(A) site recognition may facilitate persistence of negative supercoils, exposing the coding single strand and possibly allowing the nascent RNA intermittent reannealing with the template strand, for prolonged access of AID. PMID:23752228

The role of accent imitation in sensorimotor integration during processing of intelligible speech

PubMed Central

Adank, Patti; Rueschemeyer, Shirley-Ann; Bekkering, Harold

2013-01-01

Recent theories on how listeners maintain perceptual invariance despite variation in the speech signal allocate a prominent role to imitation mechanisms. Notably, these simulation accounts propose that motor mechanisms support perception of ambiguous or noisy signals. Indeed, imitation of ambiguous signals, e.g., accented speech, has been found to aid effective speech comprehension. Here, we explored the possibility that imitation in speech benefits perception by increasing activation in speech perception and production areas. Participants rated the intelligibility of sentences spoken in an unfamiliar accent of Dutch in a functional Magnetic Resonance Imaging experiment. Next, participants in one group repeated the sentences in their own accent, while a second group vocally imitated the accent. Finally, both groups rated the intelligibility of accented sentences in a post-test. The neuroimaging results showed an interaction between type of training and pre- and post-test sessions in left Inferior Frontal Gyrus, Supplementary Motor Area, and left Superior Temporal Sulcus. Although alternative explanations such as task engagement and fatigue need to be considered as well, the results suggest that imitation may aid effective speech comprehension by supporting sensorimotor integration. PMID:24109447

The Department of Defense Very High Speed Integrated Circuit (VHSIC) Technology Availability Program Plan for the Committees on Armed Services United States Congress.

DTIC Science & Technology

1986-06-30

features of computer aided design systems and statistical quality control procedures that are generic to chip sets and processes. RADIATION HARDNESS -The...System PSP Programmable Signal Processor SSI Small Scale Integration ." TOW Tube Launched, Optically Tracked, Wire Guided TTL Transistor Transitor Logic

33 CFR 62.53 - Racons.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.53 Racons. (a) Aids to navigation may... non-laterally significant aids alike, the racon signal itself is for identification purposes only, and...

33 CFR 62.53 - Racons.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.53 Racons. (a) Aids to navigation may... non-laterally significant aids alike, the racon signal itself is for identification purposes only, and...

33 CFR 62.53 - Racons.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.53 Racons. (a) Aids to navigation may... non-laterally significant aids alike, the racon signal itself is for identification purposes only, and...

A Model of Auditory-Cognitive Processing and Relevance to Clinical Applicability.

PubMed

Edwards, Brent

2016-01-01

Hearing loss and cognitive function interact in both a bottom-up and top-down relationship. Listening effort is tied to these interactions, and models have been developed to explain their relationship. The Ease of Language Understanding model in particular has gained considerable attention in its explanation of the effect of signal distortion on speech understanding. Signal distortion can also affect auditory scene analysis ability, however, resulting in a distorted auditory scene that can affect cognitive function, listening effort, and the allocation of cognitive resources. These effects are explained through an addition to the Ease of Language Understanding model. This model can be generalized to apply to all sounds, not only speech, representing the increased effort required for auditory environmental awareness and other nonspeech auditory tasks. While the authors have measures of speech understanding and cognitive load to quantify these interactions, they are lacking measures of the effect of hearing aid technology on auditory scene analysis ability and how effort and attention varies with the quality of an auditory scene. Additionally, the clinical relevance of hearing aid technology on cognitive function and the application of cognitive measures in hearing aid fittings will be limited until effectiveness is demonstrated in real-world situations.

Hearing-aid tester

NASA Technical Reports Server (NTRS)

Kessinger, R.; Polhemus, J. T.; Waring, J. G.

1977-01-01

Hearing aids are automatically checked by circuit that applies half-second test signal every thirty minutes. If hearing-aid output is distorted, too small, or if battery is too low, a warning lamp is activated. Test circuit is incorporated directly into hearing-aid package.

Using Seismic and Infrasonic Data to Identify Persistent Sources

NASA Astrophysics Data System (ADS)

Nava, S.; Brogan, R.

2014-12-01

Data from seismic and infrasound sensors were combined to aid in the identification of persistent sources such as mining-related explosions. It is of interest to operators of seismic networks to identify these signals in their event catalogs. Acoustic signals below the threshold of human hearing, in the frequency range of ~0.01 to 20 Hz are classified as infrasound. Persistent signal sources are useful as ground truth data for the study of atmospheric infrasound signal propagation, identification of manmade versus naturally occurring seismic sources, and other studies. By using signals emanating from the same location, propagation studies, for example, can be conducted using a variety of atmospheric conditions, leading to improvements to the modeling process for eventual use where the source is not known. We present results from several studies to identify ground truth sources using both seismic and infrasound data.

Vector Observation-Aided/Attitude-Rate Estimation Using Global Positioning System Signals

NASA Technical Reports Server (NTRS)

Oshman, Yaakov; Markley, F. Landis

1997-01-01

A sequential filtering algorithm is presented for attitude and attitude-rate estimation from Global Positioning System (GPS) differential carrier phase measurements. A third-order, minimal-parameter method for solving the attitude matrix kinematic equation is used to parameterize the filter's state, which renders the resulting estimator computationally efficient. Borrowing from tracking theory concepts, the angular acceleration is modeled as an exponentially autocorrelated stochastic process, thus avoiding the use of the uncertain spacecraft dynamic model. The new formulation facilitates the use of aiding vector observations in a unified filtering algorithm, which can enhance the method's robustness and accuracy. Numerical examples are used to demonstrate the performance of the method.

Hearing aid fitting for visual and hearing impaired patients with Usher syndrome type IIa.

PubMed

Hartel, B P; Agterberg, M J H; Snik, A F; Kunst, H P M; van Opstal, A J; Bosman, A J; Pennings, R J E

2017-08-01

Usher syndrome is the leading cause of hereditary deaf-blindness. Most patients with Usher syndrome type IIa start using hearing aids from a young age. A serious complaint refers to interference between sound localisation abilities and adaptive sound processing (compression), as present in today's hearing aids. The aim of this study was to investigate the effect of advanced signal processing on binaural hearing, including sound localisation. In this prospective study, patients were fitted with hearing aids with a nonlinear (compression) and linear amplification programs. Data logging was used to objectively evaluate the use of either program. Performance was evaluated with a speech-in-noise test, a sound localisation test and two questionnaires focussing on self-reported benefit. Data logging confirmed that the reported use of hearing aids was high. The linear program was used significantly more often (average use: 77%) than the nonlinear program (average use: 17%). The results for speech intelligibility in noise and sound localisation did not show a significant difference between type of amplification. However, the self-reported outcomes showed higher scores on 'ease of communication' and overall benefit, and significant lower scores on disability for the new hearing aids when compared to their previous hearing aids with compression amplification. Patients with Usher syndrome type IIa prefer a linear amplification over nonlinear amplification when fitted with novel hearing aids. Apart from a significantly higher logged use, no difference in speech in noise and sound localisation was observed between linear and nonlinear amplification with the currently used tests. Further research is needed to evaluate the reasons behind the preference for the linear settings. © 2016 The Authors. Clinical Otolaryngology Published by John Wiley & Sons Ltd.

A Practical Tablet-Based Hearing Aid Configuration as an Exemplar Project for Students of Instrumentation.

PubMed

Simeoni, Ricardo

2015-06-11

This paper presents the configuration and digital signal processing details of a tablet-based hearing aid transmitting wirelessly to standard earphones, whereby the tablet performs full sound processing rather than solely providing a means of setting adjustment by streaming to conventional digital hearing aids. The presented device confirms the recognized advantages of this tablet-based approach (e.g., in relation to cost, frequency domain processing, amplification range, versatility of functionality, component battery rechargeability), and flags the future wider-spread availability of such hearing solutions within mainstream healthcare. The use of a relatively high sampling frequency was found to be beneficial for device performance, while the use of optional off-the-shelf add-on components (e.g., data acquisition device, high fidelity microphone, compact wireless transmitter/receiver, wired headphones) are also discussed in relation to performance optimization. The easy-to-follow configuration utilized is well suited to student learning/research instrumentation projects within the health and biomedical sciences. In this latter regard, the presented device was pedagogically integrated into a flipped classroom approach for the teaching of bioinstrumentation within an Allied Health Sciences School, with the subsequent establishment of positive student engagement outcomes.

Ultrasonic inspection of carbon fiber reinforced plastic by means of sample-recognition methods

NASA Technical Reports Server (NTRS)

Bilgram, R.

1985-01-01

In the case of carbon fiber reinforced plastic (CFRP), it has not yet been possible to detect nonlocal defects and material degradation related to aging with the aid of nondestructive inspection method. An approach for overcoming difficulties regarding such an inspection involves an extension of the ultrasonic inspection procedure on the basis of a use of signal processing and sample recognition methods. The basic concept involved in this approach is related to the realization that the ultrasonic signal contains information regarding the medium which is not utilized in conventional ultrasonic inspection. However, the analytical study of the phyiscal processes involved is very complex. For this reason, an empirical approach is employed to make use of the information which has not been utilized before. This approach uses reference signals which can be obtained with material specimens of different quality. The implementation of these concepts for the supersonic inspection of CFRP laminates is discussed.

The Consonant-Weighted Envelope Difference Index (cEDI): A Proposed Technique for Quantifying Envelope Distortion

ERIC Educational Resources Information Center

Hoover, Eric C.; Souza, Pamela E.; Gallun, Frederick J.

2012-01-01

Purpose: The benefits of amplitude compression in hearing aids may be limited by distortion resulting from rapid gain adjustment. To evaluate this, it is convenient to quantify distortion by using a metric that is sensitive to the changes in the processed signal that decrease consonant recognition, such as the Envelope Difference Index (EDI;…

Terrestrial implications of mathematical modeling developed for space biomedical research

NASA Technical Reports Server (NTRS)

Lujan, Barbara F.; White, Ronald J.; Leonard, Joel I.; Srinivasan, R. Srini

1988-01-01

This paper summarizes several related research projects supported by NASA which seek to apply computer models to space medicine and physiology. These efforts span a wide range of activities, including mathematical models used for computer simulations of physiological control systems; power spectral analysis of physiological signals; pattern recognition models for detection of disease processes; and computer-aided diagnosis programs.

Applicability of mathematical modeling to problems of environmental physiology

NASA Technical Reports Server (NTRS)

White, Ronald J.; Lujan, Barbara F.; Leonard, Joel I.; Srinivasan, R. Srini

1988-01-01

The paper traces the evolution of mathematical modeling and systems analysis from terrestrial research to research related to space biomedicine and back again to terrestrial research. Topics covered include: power spectral analysis of physiological signals; pattern recognition models for detection of disease processes; and, computer-aided diagnosis programs used in conjunction with a special on-line biomedical computer library.

Real-Time, Polyphase-FFT, 640-MHz Spectrum Analyzer

NASA Technical Reports Server (NTRS)

Zimmerman, George A.; Garyantes, Michael F.; Grimm, Michael J.; Charny, Bentsian; Brown, Randy D.; Wilck, Helmut C.

1994-01-01

Real-time polyphase-fast-Fourier-transform, polyphase-FFT, spectrum analyzer designed to aid in detection of multigigahertz radio signals in two 320-MHz-wide polarization channels. Spectrum analyzer divides total spectrum of 640 MHz into 33,554,432 frequency channels of about 20 Hz each. Size and cost of polyphase-coefficient memory substantially reduced and much of processing loss of windowed FFTs eliminated.

Computer-Aided Modeling and Analysis of Power Processing Systems (CAMAPPS), phase 1

NASA Technical Reports Server (NTRS)

Kim, S.; Lee, J.; Cho, B. H.; Lee, F. C.

1986-01-01

The large-signal behaviors of a regulator depend largely on the type of power circuit topology and control. Thus, for maximum flexibility, it is best to develop models for each functional block a independent modules. A regulator can then be configured by collecting appropriate pre-defined modules for each functional block. In order to complete the component model generation for a comprehensive spacecraft power system, the following modules were developed: solar array switching unit and control; shunt regulators; and battery discharger. The capability of each module is demonstrated using a simplified Direct Energy Transfer (DET) system. Large-signal behaviors of solar array power systems were analyzed. Stability of the solar array system operating points with a nonlinear load is analyzed. The state-plane analysis illustrates trajectories of the system operating point under various conditions. Stability and transient responses of the system operating near the solar array's maximum power point are also analyzed. The solar array system mode of operation is described using the DET spacecraft power system. The DET system is simulated for various operating conditions. Transfer of the software program CAMAPPS (Computer Aided Modeling and Analysis of Power Processing Systems) to NASA/GSFC (Goddard Space Flight Center) was accomplished.

Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial.

PubMed

Kitterick, Pádraig T; O'Donoghue, Gerard M; Edmondson-Jones, Mark; Marshall, Andrew; Jeffs, Ellen; Craddock, Louise; Riley, Alison; Green, Kevin; O'Driscoll, Martin; Jiang, Dan; Nunn, Terry; Saeed, Shakeel; Aleksy, Wanda; Seeber, Bernhard U

2014-01-01

Individuals with a unilateral severe-to-profound hearing loss, or single-sided deafness, report difficulty with listening in many everyday situations despite having access to well-preserved acoustic hearing in one ear. The standard of care for single-sided deafness available on the UK National Health Service is a contra-lateral routing of signals hearing aid which transfers sounds from the impaired ear to the non-impaired ear. This hearing aid has been found to improve speech understanding in noise when the signal-to-noise ratio is more favourable at the impaired ear than the non-impaired ear. However, the indiscriminate routing of signals to a single ear can have detrimental effects when interfering sounds are located on the side of the impaired ear. Recent published evidence has suggested that cochlear implantation in individuals with a single-sided deafness can restore access to the binaural cues which underpin the ability to localise sounds and segregate speech from other interfering sounds. The current trial was designed to assess the efficacy of cochlear implantation compared to a contra-lateral routing of signals hearing aid in restoring binaural hearing in adults with acquired single-sided deafness. Patients are assessed at baseline and after receiving a contra-lateral routing of signals hearing aid. A cochlear implant is then provided to those patients who do not receive sufficient benefit from the hearing aid. This within-subject longitudinal design reflects the expected care pathway should cochlear implantation be provided for single-sided deafness on the UK National Health Service. The primary endpoints are measures of binaural hearing at baseline, after provision of a contra-lateral routing of signals hearing aid, and after cochlear implantation. Binaural hearing is assessed in terms of the accuracy with which sounds are localised and speech is perceived in background noise. The trial is also designed to measure the impact of the interventions on hearing- and health-related quality of life. This multi-centre trial was designed to provide evidence for the efficacy of cochlear implantation compared to the contra-lateral routing of signals. A purpose-built sound presentation system and established measurement techniques will provide reliable and precise measures of binaural hearing. Current Controlled Trials http://www.controlled-trials.com/ISRCTN33301739 (05/JUL/2013).

Plant hormone signaling during development: insights from computational models.

PubMed

Oliva, Marina; Farcot, Etienne; Vernoux, Teva

2013-02-01

Recent years have seen an impressive increase in our knowledge of the topology of plant hormone signaling networks. The complexity of these topologies has motivated the development of models for several hormones to aid understanding of how signaling networks process hormonal inputs. Such work has generated essential insights into the mechanisms of hormone perception and of regulation of cellular responses such as transcription in response to hormones. In addition, modeling approaches have contributed significantly to exploring how spatio-temporal regulation of hormone signaling contributes to plant growth and patterning. New tools have also been developed to obtain quantitative information on hormone distribution during development and to test model predictions, opening the way for quantitative understanding of the developmental roles of hormones. Copyright © 2012 Elsevier Ltd. All rights reserved.

Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex.

PubMed

Rizzetto, Lisa; Fava, Francesca; Tuohy, Kieran M; Selmi, Carlo

2018-05-31

Unresolved low grade systemic inflammation represents the underlying pathological mechanism driving immune and metabolic pathways involved in autoimmune diseases (AID). Mechanistic studies in animal models of AID and observational studies in patients have found alterations in gut microbiota communities and their metabolites, suggesting a microbial contribution to the onset or progression of AID. The gut microbiota and its metabolites have been shown to influence immune functions and immune homeostasis both within the gut and systematically. Microbial derived-short chain fatty acid (SCFA) and bio-transformed bile acid (BA) have been shown to influence the immune system acting as ligands specific cell signaling receptors like GPRCs, TGR5 and FXR, or via epigenetic processes. Similarly, intestinal permeability (leaky gut) and bacterial translocation are important contributors to chronic systemic inflammation and, without repair of the intestinal barrier, might represent a continuous inflammatory stimulus capable of triggering autoimmune processes. Recent studies indicate gender-specific differences in immunity, with the gut microbiota shaping and being concomitantly shaped by the hormonal milieu governing differences between the sexes. A bi-directional cross-talk between microbiota and the endocrine system is emerging with bacteria being able to produce hormones (e.g. serotonin, dopamine and somatostatine), respond to host hormones (e.g. estrogens) and regulate host hormones' homeostasis (e.g by inhibiting gene prolactin transcription or converting glucocorticoids to androgens). We review herein how gut microbiota and its metabolites regulate immune function, intestinal permeability and possibly AID pathological processes. Further, we describe the dysbiosis within the gut microbiota observed in different AID and speculate how restoring gut microbiota composition and its regulatory metabolites by dietary intervention including prebiotics and probiotics could help in preventing or ameliorating AID. Finally, we suggest that, given consistent observations of microbiota dysbiosis associated with AID and the ability of SCFA and BA to regulate intestinal permeability and inflammation, further mechanistic studies, examining how dietary microbiota modulation can protect against AID, hold considerable potential to tackle increased incidence of AID at the population level. Copyright © 2018 Elsevier Ltd. All rights reserved.

Pilot-aided feedforward data recovery in optical coherent communications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Bing

2017-09-19

A method and a system for pilot-aided feedforward data recovery are provided. The method and system include a receiver including a strong local oscillator operating in a free running mode independent of a signal light source. The phase relation between the signal light source and the local oscillator source is determined based on quadrature measurements on pilot pulses from the signal light source. Using the above phase relation, information encoded in an incoming signal can be recovered, optionally for use in communication with classical coherent communication protocols and quantum communication protocols.

Very low-frequency signals support perceptual organization of implant-simulated speech for adults and children

PubMed Central

Nittrouer, Susan; Tarr, Eric; Bolster, Virginia; Caldwell-Tarr, Amanda; Moberly, Aaron C.; Lowenstein, Joanna H.

2014-01-01

Objective Using signals processed to simulate speech received through cochlear implants and low-frequency extended hearing aids, this study examined the proposal that low-frequency signals facilitate the perceptual organization of broader, spectrally degraded signals. Design In two experiments, words and sentences were presented in diotic and dichotic configurations as four-channel noise-vocoded signals (VOC-only), and as those signals combined with the acoustic signal below 250 Hz (LOW-plus). Dependent measures were percent correct recognition scores, and the difference between scores for the two processing conditions given as proportions of recognition scores for VOC-only. The influence of linguistic context was also examined. Study Sample Participants had normal hearing. In all, 40 adults, 40 7-year-olds, and 20 5-year-olds participated. Results Participants of all ages showed benefits of adding the low-frequency signal. The effect was greater for sentences than words, but no effect of configuration was found. The influence of linguistic context was similar across age groups, and did not contribute to the low-frequency effect. Listeners who scored more poorly with VOC-only stimuli showed greater low-frequency effects. Conclusion The benefit of adding a very low-frequency signal to a broader, spectrally degraded signal seems to derive from its facilitative influence on perceptual organization of the sensory input. PMID:24456179

Hearing Aids and Hearing Impaired Students in Rural Schools.

ERIC Educational Resources Information Center

Woodford, Charles

This paper describes functions of the components of hearing aids and provides a detailed procedure to detect hearing aid dysfunctions. The most common type of hearing aids for school children are the behind the ear type. Various hearing aid components change sound into an electrical signal, which is amplified and adjusted by a volume control. The…

A novel multireceiver communications system configuration based on optimal estimation theory

NASA Technical Reports Server (NTRS)

Kumar, R.

1990-01-01

A multireceiver configuration for the purpose of carrier arraying and/or signal arraying is presented. Such a problem arises for example, in the NASA Deep Space Network where the same data-modulated signal from a spacecraft is received by a number of geographically separated antennas and the data detection must be efficiently performed on the basis of the various received signals. The proposed configuration is arrived at by formulating the carrier and/or signal arraying problem as an optimal estimation problem. Two specific solutions are proposed. The first solution is to simultaneously and optimally estimate the various phase processes received at different receivers with coupled phase locked loops (PLLs) wherein the individual PLLs acquire and track their respective receivers' phase processes, but are aided by each other in an optimal manner. However, when the phase processes are relatively weakly correlated, and for the case of relatively high values of symbol energy-to-noise spectral density ratio, a novel configuration for combining the data modulated, loop-output signals is proposed. The scheme can be extended to the case of low symbol energy-to-noise case by performing the combining/detection process over a multisymbol period. Such a configuration results in the minimization of the effective radio loss at the combiner output, and thus a maximization of energy per bit to noise-power spectral density ration is achieved.

Brainstem Encoding of Aided Speech in Hearing Aid Users with Cochlear Dead Region(s).

PubMed

Hassaan, Mohammad Ramadan; Ibraheem, Ola Abdallah; Galhom, Dalia Helal

2016-07-01

Neural encoding of speech begins with the analysis of the signal as a whole broken down into its sinusoidal components in the cochlea, which has to be conserved up to the higher auditory centers. Some of these components target the dead regions of the cochlea causing little or no excitation. Measuring aided speech-evoked auditory brainstem response elicited by speech stimuli with different spectral maxima can give insight into the brainstem encoding of aided speech with spectral maxima at these dead regions. This research aims to study the impact of dead regions of the cochlea on speech processing at the brainstem level after a long period of hearing aid use. This study comprised 30 ears without dead regions and 46 ears with dead regions at low, mid, or high frequencies. For all ears, we measured the aided speech-evoked auditory brainstem response using speech stimuli of low, mid, and high spectral maxima. Aided speech-evoked auditory brainstem response was producible in all subjects. Responses evoked by stimuli with spectral maxima at dead regions had longer latencies and smaller amplitudes when compared with the control group or the responses of other stimuli. The presence of cochlear dead regions affects brainstem encoding of speech with spectral maxima perpendicular to these regions. Brainstem neuroplasticity and the extrinsic redundancy of speech can minimize the impact of dead regions in chronic hearing aid users.

High-frequency amplification and sound quality in listeners with normal through moderate hearing loss.

PubMed

Ricketts, Todd A; Dittberner, Andrew B; Johnson, Earl E

2008-02-01

One factor that has been shown to greatly affect sound quality is audible bandwidth. Provision of gain for frequencies above 4-6 kHz has not generally been supported for groups of hearing aid wearers. The purpose of this study was to determine if preference for bandwidth extension in hearing aid processed sounds was related to the magnitude of hearing loss in individual listeners. Ten participants with normal hearing and 20 participants with mild-to-moderate hearing loss completed the study. Signals were processed using hearing aid-style compression algorithms and filtered using two cutoff frequencies, 5.5 and 9 kHz, which were selected to represent bandwidths that are achievable in modern hearing aids. Round-robin paired comparisons based on the criteria of preferred sound quality were made for 2 different monaurally presented brief sound segments, including music and a movie. Results revealed that preference for either the wider or narrower bandwidth (9- or 5.5-kHz cutoff frequency, respectively) was correlated with the slope of hearing loss from 4 to 12 kHz, with steep threshold slopes associated with preference for narrower bandwidths. Consistent preference for wider bandwidth is present in some listeners with mild-to-moderate hearing loss.

33 CFR 67.20-10 - Sound signal.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sound signal. 67.20-10 Section 67.20-10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES Class âAâ Requirements § 67.20-10 Sound...

33 CFR 67.15-1 - Lights and signals on attendant vessels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights and signals on attendant vessels. 67.15-1 Section 67.15-1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES Miscellaneous...

33 CFR 67.20-10 - Sound signal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sound signal. 67.20-10 Section 67.20-10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES Class âAâ Requirements § 67.20-10 Sound...

Optical-to-Tactile Translator

NASA Technical Reports Server (NTRS)

Langevin, Maurice L. (Inventor); Moynihan, Philip I. (Inventor)

2000-01-01

An optical-to-tactile translator provides an aid for the visually impaired by translating a near-field scene to a tactile signal corresponding to said near-field scene. An optical sensor using a plurality of active pixel sensors (APS) converts the optical image within the near-field scene to a digital signal. The digital signal is then processed by a microprocessor and a simple shape signal is generated based on the digital signal. The shape signal is then communicated to a tactile transmitter where the shape signal is converted into a tactile signal using a series of contacts. The shape signal may be an outline of the significant shapes determined in the near-field scene, or the shape signal may comprise a simple symbolic representation of common items encountered repeatedly. The user is thus made aware of the unseen near-field scene, including potential obstacles and dangers, through a series of tactile contacts. In a preferred embodiment, a range determining device such as those commonly found on auto-focusing cameras is included to limit the distance that the optical sensor interprets the near-field scene.

A smart multisensor approach to assist blind people in specific urban navigation tasks.

PubMed

Ando, B

2008-12-01

Visually impaired people are often discouraged in using electronic aids due to complexity of operation, large amount of training, nonoptimized degree of information provided to the user, and high cost. In this paper, a new multisensor architecture is discussed, which would help blind people to perform urban mobility tasks. The device is based on a multisensor strategy and adopts smart signal processing.

Chemical genetics and regeneration.

PubMed

Sengupta, Sumitra; Zhang, Liyun; Mumm, Jeff S

2015-01-01

Regeneration involves interactions between multiple signaling pathways acting in a spatially and temporally complex manner. As signaling pathways are highly conserved, understanding how regeneration is controlled in animal models exhibiting robust regenerative capacities should aid efforts to stimulate repair in humans. One way to discover molecular regulators of regeneration is to alter gene/protein function and quantify effect(s) on the regenerative process: dedifferentiation/reprograming, stem/progenitor proliferation, migration/remodeling, progenitor cell differentiation and resolution. A powerful approach for applying this strategy to regenerative biology is chemical genetics, the use of small-molecule modulators of specific targets or signaling pathways. Here, we review advances that have been made using chemical genetics for hypothesis-focused and discovery-driven studies aimed at furthering understanding of how regeneration is controlled.

Brain Signal Variability is Parametrically Modifiable

PubMed Central

Garrett, Douglas D.; McIntosh, Anthony R.; Grady, Cheryl L.

2014-01-01

Moment-to-moment brain signal variability is a ubiquitous neural characteristic, yet remains poorly understood. Evidence indicates that heightened signal variability can index and aid efficient neural function, but it is not known whether signal variability responds to precise levels of environmental demand, or instead whether variability is relatively static. Using multivariate modeling of functional magnetic resonance imaging-based parametric face processing data, we show here that within-person signal variability level responds to incremental adjustments in task difficulty, in a manner entirely distinct from results produced by examining mean brain signals. Using mixed modeling, we also linked parametric modulations in signal variability with modulations in task performance. We found that difficulty-related reductions in signal variability predicted reduced accuracy and longer reaction times within-person; mean signal changes were not predictive. We further probed the various differences between signal variance and signal means by examining all voxels, subjects, and conditions; this analysis of over 2 million data points failed to reveal any notable relations between voxel variances and means. Our results suggest that brain signal variability provides a systematic task-driven signal of interest from which we can understand the dynamic function of the human brain, and in a way that mean signals cannot capture. PMID:23749875

Cognitive Spare Capacity and Speech Communication: A Narrative Overview

PubMed Central

2014-01-01

Background noise can make speech communication tiring and cognitively taxing, especially for individuals with hearing impairment. It is now well established that better working memory capacity is associated with better ability to understand speech under adverse conditions as well as better ability to benefit from the advanced signal processing in modern hearing aids. Recent work has shown that although such processing cannot overcome hearing handicap, it can increase cognitive spare capacity, that is, the ability to engage in higher level processing of speech. This paper surveys recent work on cognitive spare capacity and suggests new avenues of investigation. PMID:24971355

Phase coherence adaptive processor for automatic signal detection and identification

NASA Astrophysics Data System (ADS)

Wagstaff, Ronald A.

2006-05-01

A continuously adapting acoustic signal processor with an automatic detection/decision aid is presented. Its purpose is to preserve the signals of tactical interest, and filter out other signals and noise. It utilizes single sensor or beamformed spectral data and transforms the signal and noise phase angles into "aligned phase angles" (APA). The APA increase the phase temporal coherence of signals and leave the noise incoherent. Coherence thresholds are set, which are representative of the type of source "threat vehicle" and the geographic area or volume in which it is operating. These thresholds separate signals, based on the "quality" of their APA coherence. An example is presented in which signals from a submerged source in the ocean are preserved, while clutter signals from ships and noise are entirely eliminated. Furthermore, the "signals of interest" were identified by the processor's automatic detection aid. Similar performance is expected for air and ground vehicles. The processor's equations are formulated in such a manner that they can be tuned to eliminate noise and exploit signal, based on the "quality" of their APA temporal coherence. The mathematical formulation for this processor is presented, including the method by which the processor continuously self-adapts. Results show nearly complete elimination of noise, with only the selected category of signals remaining, and accompanying enhancements in spectral and spatial resolution. In most cases, the concept of signal-to-noise ratio looses significance, and "adaptive automated /decision aid" is more relevant.

Listening Effort and Speech Recognition with Frequency Compression Amplification for Children and Adults with Hearing Loss.

PubMed

Brennan, Marc A; Lewis, Dawna; McCreery, Ryan; Kopun, Judy; Alexander, Joshua M

2017-10-01

Nonlinear frequency compression (NFC) can improve the audibility of high-frequency sounds by lowering them to a frequency where audibility is better; however, this lowering results in spectral distortion. Consequently, performance is a combination of the effects of increased access to high-frequency sounds and the detrimental effects of spectral distortion. Previous work has demonstrated positive benefits of NFC on speech recognition when NFC is set to improve audibility while minimizing distortion. However, the extent to which NFC impacts listening effort is not well understood, especially for children with sensorineural hearing loss (SNHL). To examine the impact of NFC on recognition and listening effort for speech in adults and children with SNHL. Within-subject, quasi-experimental study. Participants listened to amplified nonsense words that were (1) frequency-lowered using NFC, (2) low-pass filtered at 5 kHz to simulate the restricted bandwidth (RBW) of conventional hearing aid processing, or (3) low-pass filtered at 10 kHz to simulate extended bandwidth (EBW) amplification. Fourteen children (8-16 yr) and 14 adults (19-65 yr) with mild-to-severe SNHL. Participants listened to speech processed by a hearing aid simulator that amplified input signals to fit a prescriptive target fitting procedure. Participants were blinded to the type of processing. Participants' responses to each nonsense word were analyzed for accuracy and verbal-response time (VRT; listening effort). A multivariate analysis of variance and linear mixed model were used to determine the effect of hearing-aid signal processing on nonsense word recognition and VRT. Both children and adults identified the nonsense words and initial consonants better with EBW and NFC than with RBW. The type of processing did not affect the identification of the vowels or final consonants. There was no effect of age on recognition of the nonsense words, initial consonants, medial vowels, or final consonants. VRT did not change significantly with the type of processing or age. Both adults and children demonstrated improved speech recognition with access to the high-frequency sounds in speech. Listening effort as measured by VRT was not affected by access to high-frequency sounds. American Academy of Audiology

Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial

PubMed Central

2014-01-01

Background Individuals with a unilateral severe-to-profound hearing loss, or single-sided deafness, report difficulty with listening in many everyday situations despite having access to well-preserved acoustic hearing in one ear. The standard of care for single-sided deafness available on the UK National Health Service is a contra-lateral routing of signals hearing aid which transfers sounds from the impaired ear to the non-impaired ear. This hearing aid has been found to improve speech understanding in noise when the signal-to-noise ratio is more favourable at the impaired ear than the non-impaired ear. However, the indiscriminate routing of signals to a single ear can have detrimental effects when interfering sounds are located on the side of the impaired ear. Recent published evidence has suggested that cochlear implantation in individuals with a single-sided deafness can restore access to the binaural cues which underpin the ability to localise sounds and segregate speech from other interfering sounds. Methods/Design The current trial was designed to assess the efficacy of cochlear implantation compared to a contra-lateral routing of signals hearing aid in restoring binaural hearing in adults with acquired single-sided deafness. Patients are assessed at baseline and after receiving a contra-lateral routing of signals hearing aid. A cochlear implant is then provided to those patients who do not receive sufficient benefit from the hearing aid. This within-subject longitudinal design reflects the expected care pathway should cochlear implantation be provided for single-sided deafness on the UK National Health Service. The primary endpoints are measures of binaural hearing at baseline, after provision of a contra-lateral routing of signals hearing aid, and after cochlear implantation. Binaural hearing is assessed in terms of the accuracy with which sounds are localised and speech is perceived in background noise. The trial is also designed to measure the impact of the interventions on hearing- and health-related quality of life. Discussion This multi-centre trial was designed to provide evidence for the efficacy of cochlear implantation compared to the contra-lateral routing of signals. A purpose-built sound presentation system and established measurement techniques will provide reliable and precise measures of binaural hearing. Trial registration Current Controlled Trials http://www.controlled-trials.com/ISRCTN33301739 (05/JUL/2013) PMID:25152694

Discriminator aided phase lock acquisition for suppressed carrier signals

NASA Technical Reports Server (NTRS)

Carson, L. M.; Krasin, F. E. (Inventor)

1982-01-01

A discriminator aided technique for acquisition of phase lock to a suppressed carrier signal utilizes a Costas loop which is initially operated open loop and control voltage for its VCXO is derived from a phase detector that compares the VCXO to a reference frequency thus establishing coarse frequency resolution with the received signal. Then the Costas loop is closed with the low-pass filter of the channel having a bandwidth much greater (by a factor of about 10) than in the I channel so that a frequency discriminator effect results to aid carrier resolution. Finally, after carrier acquisition, the Q-channel filter of the Costas loop is switched to a bandwidth substantially equal to that of the I-channel for carrier tracking.

Nonlinear Frequency Compression in Hearing Aids: Impact on Speech and Language Development

PubMed Central

Bentler, Ruth; Walker, Elizabeth; McCreery, Ryan; Arenas, Richard M.; Roush, Patricia

2015-01-01

Objectives The research questions of this study were: (1) Are children using nonlinear frequency compression (NLFC) in their hearing aids getting better access to the speech signal than children using conventional processing schemes? The authors hypothesized that children whose hearing aids provided wider input bandwidth would have more access to the speech signal, as measured by an adaptation of the Speech Intelligibility Index, and (2) are speech and language skills different for children who have been fit with the two different technologies; if so, in what areas? The authors hypothesized that if the children were getting increased access to the speech signal as a result of their NLFC hearing aids (question 1), it would be possible to see improved performance in areas of speech production, morphosyntax, and speech perception compared with the group with conventional processing. Design Participants included 66 children with hearing loss recruited as part of a larger multisite National Institutes of Health–funded study, Outcomes for Children with Hearing Loss, designed to explore the developmental outcomes of children with mild to severe hearing loss. For the larger study, data on communication, academic and psychosocial skills were gathered in an accelerated longitudinal design, with entry into the study between 6 months and 7 years of age. Subjects in this report consisted of 3-, 4-, and 5-year-old children recruited at the North Carolina test site. All had at least at least 6 months of current hearing aid usage with their NLFC or conventional amplification. Demographic characteristics were compared at the three age levels as well as audibility and speech/language outcomes; speech-perception scores were compared for the 5-year-old groups. Results Results indicate that the audibility provided did not differ between the technology options. As a result, there was no difference between groups on speech or language outcome measures at 4 or 5 years of age, and no impact on speech perception (measured at 5 years of age). The difference in Comprehensive Assessment of Spoken Language and mean length of utterance scores for the 3-year-old group favoring the group with conventional amplification may be a consequence of confounding factors such as increased incidence of prematurity in the group using NLFC. Conclusions Children fit with NLFC had similar audibility, as measured by a modified Speech Intelligibility Index, compared with a matched group of children using conventional technology. In turn, there were no differences in their speech and language abilities. PMID:24892229

Nonlinear frequency compression in hearing aids: impact on speech and language development.

PubMed

Bentler, Ruth; Walker, Elizabeth; McCreery, Ryan; Arenas, Richard M; Roush, Patricia

2014-01-01

The research questions of this study were: (1) Are children using nonlinear frequency compression (NLFC) in their hearing aids getting better access to the speech signal than children using conventional processing schemes? The authors hypothesized that children whose hearing aids provided wider input bandwidth would have more access to the speech signal, as measured by an adaptation of the Speech Intelligibility Index, and (2) are speech and language skills different for children who have been fit with the two different technologies; if so, in what areas? The authors hypothesized that if the children were getting increased access to the speech signal as a result of their NLFC hearing aids (question 1), it would be possible to see improved performance in areas of speech production, morphosyntax, and speech perception compared with the group with conventional processing. Participants included 66 children with hearing loss recruited as part of a larger multisite National Institutes of Health-funded study, Outcomes for Children with Hearing Loss, designed to explore the developmental outcomes of children with mild to severe hearing loss. For the larger study, data on communication, academic and psychosocial skills were gathered in an accelerated longitudinal design, with entry into the study between 6 months and 7 years of age. Subjects in this report consisted of 3-, 4-, and 5-year-old children recruited at the North Carolina test site. All had at least at least 6 months of current hearing aid usage with their NLFC or conventional amplification. Demographic characteristics were compared at the three age levels as well as audibility and speech/language outcomes; speech-perception scores were compared for the 5-year-old groups. Results indicate that the audibility provided did not differ between the technology options. As a result, there was no difference between groups on speech or language outcome measures at 4 or 5 years of age, and no impact on speech perception (measured at 5 years of age). The difference in Comprehensive Assessment of Spoken Language and mean length of utterance scores for the 3-year-old group favoring the group with conventional amplification may be a consequence of confounding factors such as increased incidence of prematurity in the group using NLFC. Children fit with NLFC had similar audibility, as measured by a modified Speech Intelligibility Index, compared with a matched group of children using conventional technology. In turn, there were no differences in their speech and language abilities.

Measuring radio-signal power accurately

NASA Technical Reports Server (NTRS)

Goldstein, R. M.; Newton, J. W.; Winkelstein, R. A.

1979-01-01

Absolute value of signal power in weak radio signals is determined by computer-aided measurements. Equipment operates by averaging received signal over several-minute period and comparing average value with noise level of receiver previously calibrated.

Developing Signal-Pattern-Recognition Programs

NASA Technical Reports Server (NTRS)

Shelton, Robert O.; Hammen, David

2006-01-01

Pattern Interpretation and Recognition Application Toolkit Environment (PIRATE) is a block-oriented software system that aids the development of application programs that analyze signals in real time in order to recognize signal patterns that are indicative of conditions or events of interest. PIRATE was originally intended for use in writing application programs to recognize patterns in space-shuttle telemetry signals received at Johnson Space Center's Mission Control Center: application programs were sought to (1) monitor electric currents on shuttle ac power busses to recognize activations of specific power-consuming devices, (2) monitor various pressures and infer the states of affected systems by applying a Kalman filter to the pressure signals, (3) determine fuel-leak rates from sensor data, (4) detect faults in gyroscopes through analysis of system measurements in the frequency domain, and (5) determine drift rates in inertial measurement units by regressing measurements against time. PIRATE can also be used to develop signal-pattern-recognition software for different purposes -- for example, to monitor and control manufacturing processes.

New instantaneous frequency estimation method based on the use of image processing techniques

NASA Astrophysics Data System (ADS)

Borda, Monica; Nafornita, Ioan; Isar, Alexandru

2003-05-01

The aim of this paper is to present a new method for the estimation of the instantaneous frequency of a frequency modulated signal, corrupted by additive noise. This method represents an example of fusion of two theories: the time-frequency representations and the mathematical morphology. Any time-frequency representation of a useful signal is concentrated around its instantaneous frequency law and realizes the diffusion of the noise that perturbs the useful signal in the time - frequency plane. In this paper a new time-frequency representation, useful for the estimation of the instantaneous frequency, is proposed. This time-frequency representation is the product of two others time-frequency representations: the Wigner - Ville time-frequency representation and a new one obtained by filtering with a hard thresholding filter the Gabor representation of the signal to be processed. Using the image of this new time-frequency representation the instantaneous frequency of the useful signal can be extracted with the aid of some mathematical morphology operators: the conversion in binary form, the dilation and the skeleton. The simulations of the proposed method have proved its qualities. It is better than other estimation methods, like those based on the use of adaptive notch filters.

Semi-automated based ground-truthing GUI for airborne imagery

NASA Astrophysics Data System (ADS)

Phan, Chung; Lydic, Rich; Moore, Tim; Trang, Anh; Agarwal, Sanjeev; Tiwari, Spandan

2005-06-01

Over the past several years, an enormous amount of airborne imagery consisting of various formats has been collected and will continue into the future to support airborne mine/minefield detection processes, improve algorithm development, and aid in imaging sensor development. The ground-truthing of imagery is a very essential part of the algorithm development process to help validate the detection performance of the sensor and improving algorithm techniques. The GUI (Graphical User Interface) called SemiTruth was developed using Matlab software incorporating signal processing, image processing, and statistics toolboxes to aid in ground-truthing imagery. The semi-automated ground-truthing GUI is made possible with the current data collection method, that is including UTM/GPS (Universal Transverse Mercator/Global Positioning System) coordinate measurements for the mine target and fiducial locations on the given minefield layout to support in identification of the targets on the raw imagery. This semi-automated ground-truthing effort has developed by the US Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD), Countermine Division, Airborne Application Branch with some support by the University of Missouri-Rolla.

Distinct processing of social and monetary rewards in late adolescents with trait anhedonia.

PubMed

Chan, Raymond C K; Li, Zhi; Li, Ke; Zeng, Ya-Wei; Xie, Wei-Zhen; Yan, Chao; Cheung, Eric F C; Jin, Zhen

2016-03-01

Anticipatory and consummatory dissociation of hedonic experience may manifest as trait anhedonia in healthy and clinical populations. It is still unclear whether the underlying neural mechanisms of the monetary-based and affect-based incentive delay paradigms are distinct from each other. The present study aimed to examine the similarities and differences between the Affect Incentive Delay (AID) and the Monetary Incentive Delay (MID) imaging paradigms in relation to brain activations. We administered the AID and the MID imaging tasks to 28 adolescent participants. A cue signaling the type of forthcoming feedback (reward or punishment) was displayed to the participants, followed by a target-hit task with corresponding reward or punishment. The striatal and limbic regions were activated during the anticipatory phase of MID, while there was no brain activation during the anticipatory phase of AID. In the consummatory phase, the MID task activated the medial frontal cortex, while the AID task activated the frontal and dorsal limbic regions. We further found that the anhedonic group exhibited significant hypoactivation than the nonanhedonic group at the left pulvinar, the left claustrum and the left insula to positive cues in the anticipatory phase of the AID task. The results suggest that the AID and the MID tasks have unique activation patterns. Our findings also suggest that the AID task may be more sensitive in detecting anhedonia in people with trait anhedonia. (c) 2016 APA, all rights reserved).

AlliedSignal driver's viewer enhancement (DVE) for paramilitary and commercial applications

NASA Astrophysics Data System (ADS)

Emanuel, Michael; Caron, Hubert; Kovacevic, Branislav; Faina-Cherkaoui, Marcela; Wrobel, Leslie; Turcotte, Gilles

1999-07-01

AlliedSignal Driver's Viewer Enhancement (DVE) system is a thermal imager using a 320 X 240 uncooled microbolometer array. This high performance system was initially developed for military combat and tactical wheeled vehicles. It features a very small sensor head remotely mounted from the display, control and processing module. The sensor head has a modular design and is being adapted to various commercial applications such as truck and car-driving aid, using specifically designed low cost optics. Tradeoffs in the system design, system features and test results are discussed in this paper. A short video shows footage of the DVE system while driving at night.

Medical diagnosis system and method with multispectral imaging. [depth of burns and optical density of the skin

NASA Technical Reports Server (NTRS)

Anselmo, V. J.; Reilly, T. H. (Inventor)

1979-01-01

A skin diagnosis system includes a scanning and optical arrangement whereby light reflected from each incremental area (pixel) of the skin is directed simultaneously to three separate light filters, e.g., IR, red, and green. As a result, the three devices simultaneously produce three signals which are directly related to the reflectance of light of different wavelengths from the corresponding pixel. These three signals for each pixel after processing are used as inputs to one or more output devices to produce a visual color display and/or a hard copy color print, for one usable as a diagnostic aid by a physician.

Understanding Resolvin Signaling Pathways to Improve Oral Health

PubMed Central

Keinan, David; Leigh, Noel J.; Nelson, Joel W.; De Oleo, Laura; Baker, Olga J.

2013-01-01

The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity. PMID:23528855

Multichannel loudness compensation method based on segmented sound pressure level for digital hearing aids

NASA Astrophysics Data System (ADS)

Liang, Ruiyu; Xi, Ji; Bao, Yongqiang

2017-07-01

To improve the performance of gain compensation based on three-segment sound pressure level (SPL) in hearing aids, an improved multichannel loudness compensation method based on eight-segment SPL was proposed. Firstly, the uniform cosine modulated filter bank was designed. Then, the adjacent channels which have low or gradual slopes were adaptively merged to obtain the corresponding non-uniform cosine modulated filter according to the audiogram of hearing impaired persons. Secondly, the input speech was decomposed into sub-band signals and the SPL of every sub-band signal was computed. Meanwhile, the audible SPL range from 0 dB SPL to 120 dB SPL was equally divided into eight segments. Based on these segments, a different prescription formula was designed to compute more detailed gain to compensate according to the audiogram and the computed SPL. Finally, the enhanced signal was synthesized. Objective experiments showed the decomposed signals after cosine modulated filter bank have little distortion. Objective experiments showed that the hearing aids speech perception index (HASPI) and hearing aids speech quality index (HASQI) increased 0.083 and 0.082 on average, respectively. Subjective experiments showed the proposed algorithm can effectively improve the speech recognition of six hearing impaired persons.

Fast-Acquisition/Weak-Signal-Tracking GPS Receiver for HEO

NASA Technical Reports Server (NTRS)

Wintemitz, Luke; Boegner, Greg; Sirotzky, Steve

2004-01-01

A report discusses the technical background and design of the Navigator Global Positioning System (GPS) receiver -- . a radiation-hardened receiver intended for use aboard spacecraft. Navigator is capable of weak signal acquisition and tracking as well as much faster acquisition of strong or weak signals with no a priori knowledge or external aiding. Weak-signal acquisition and tracking enables GPS use in high Earth orbits (HEO), and fast acquisition allows for the receiver to remain without power until needed in any orbit. Signal acquisition and signal tracking are, respectively, the processes of finding and demodulating a signal. Acquisition is the more computationally difficult process. Previous GPS receivers employ the method of sequentially searching the two-dimensional signal parameter space (code phase and Doppler). Navigator exploits properties of the Fourier transform in a massively parallel search for the GPS signal. This method results in far faster acquisition times [in the lab, 12 GPS satellites have been acquired with no a priori knowledge in a Low-Earth-Orbit (LEO) scenario in less than one second]. Modeling has shown that Navigator will be capable of acquiring signals down to 25 dB-Hz, appropriate for HEO missions. Navigator is built using the radiation-hardened ColdFire microprocessor and housing the most computationally intense functions in dedicated field-programmable gate arrays. The high performance of the algorithm and of the receiver as a whole are made possible by optimizing computational efficiency and carefully weighing tradeoffs among the sampling rate, data format, and data-path bit width.

Brainstem Encoding of Aided Speech in Hearing Aid Users with Cochlear Dead Region(s)

PubMed Central

Hassaan, Mohammad Ramadan; Ibraheem, Ola Abdallah; Galhom, Dalia Helal

2016-01-01

Introduction  Neural encoding of speech begins with the analysis of the signal as a whole broken down into its sinusoidal components in the cochlea, which has to be conserved up to the higher auditory centers. Some of these components target the dead regions of the cochlea causing little or no excitation. Measuring aided speech-evoked auditory brainstem response elicited by speech stimuli with different spectral maxima can give insight into the brainstem encoding of aided speech with spectral maxima at these dead regions. Objective  This research aims to study the impact of dead regions of the cochlea on speech processing at the brainstem level after a long period of hearing aid use. Methods  This study comprised 30 ears without dead regions and 46 ears with dead regions at low, mid, or high frequencies. For all ears, we measured the aided speech-evoked auditory brainstem response using speech stimuli of low, mid, and high spectral maxima. Results  Aided speech-evoked auditory brainstem response was producible in all subjects. Responses evoked by stimuli with spectral maxima at dead regions had longer latencies and smaller amplitudes when compared with the control group or the responses of other stimuli. Conclusion  The presence of cochlear dead regions affects brainstem encoding of speech with spectral maxima perpendicular to these regions. Brainstem neuroplasticity and the extrinsic redundancy of speech can minimize the impact of dead regions in chronic hearing aid users. PMID:27413404

Hearing loss is negatively related to episodic and semantic long-term memory but not to short-term memory.

PubMed

Rönnberg, Jerker; Danielsson, Henrik; Rudner, Mary; Arlinger, Stig; Sternäng, Ola; Wahlin, Ake; Nilsson, Lars-Göran

2011-04-01

To test the relationship between degree of hearing loss and different memory systems in hearing aid users. Structural equation modeling (SEM) was used to study the relationship between auditory and visual acuity and different cognitive and memory functions in an age-hetereogenous subsample of 160 hearing aid users without dementia, drawn from the Swedish prospective cohort aging study known as Betula (L.-G. Nilsson et al., 1997). Hearing loss was selectively and negatively related to episodic and semantic long-term memory (LTM) but not short-term memory (STM) performance. This held true for both ears, even when age was accounted for. Visual acuity alone, or in combination with auditory acuity, did not contribute to any acceptable SEM solution. The overall relationships between hearing loss and memory systems were predicted by the ease of language understanding model (J. Rönnberg, 2003), but the exact mechanisms of episodic memory decline in hearing aid users (i.e., mismatch/disuse, attentional resources, or information degradation) remain open for further experiments. The hearing aid industry should strive to design signal processing algorithms that are cognition friendly.

A Signal Processing Module for the Analysis of Heart Sounds and Heart Murmurs

NASA Astrophysics Data System (ADS)

Javed, Faizan; Venkatachalam, P. A.; H, Ahmad Fadzil M.

2006-04-01

In this paper a Signal Processing Module (SPM) for the computer-aided analysis of heart sounds has been developed. The module reveals important information of cardiovascular disorders and can assist general physician to come up with more accurate and reliable diagnosis at early stages. It can overcome the deficiency of expert doctors in rural as well as urban clinics and hospitals. The module has five main blocks: Data Acquisition & Pre-processing, Segmentation, Feature Extraction, Murmur Detection and Murmur Classification. The heart sounds are first acquired using an electronic stethoscope which has the capability of transferring these signals to the near by workstation using wireless media. Then the signals are segmented into individual cycles as well as individual components using the spectral analysis of heart without using any reference signal like ECG. Then the features are extracted from the individual components using Spectrogram and are used as an input to a MLP (Multiple Layer Perceptron) Neural Network that is trained to detect the presence of heart murmurs. Once the murmur is detected they are classified into seven classes depending on their timing within the cardiac cycle using Smoothed Pseudo Wigner-Ville distribution. The module has been tested with real heart sounds from 40 patients and has proved to be quite efficient and robust while dealing with a large variety of pathological conditions.

Computer-aided diagnosis of leukoencephalopathy in children treated for acute lymphoblastic leukemia

NASA Astrophysics Data System (ADS)

Glass, John O.; Li, Chin-Shang; Helton, Kathleen J.; Reddick, Wilburn E.

2005-04-01

The purpose of this study was to use objective quantitative MR imaging methods to develop a computer-aided diagnosis tool to differentiate white matter (WM) hyperintensities as either leukoencephalopathy (LE) or normal maturational processes in children treated for acute lymphoblastic leukemia with intravenous high dose methotrexate. A combined imaging set consisting of T1, T2, PD, and FLAIR MR images and WM, gray matter, and cerebrospinal fluid a priori maps from a spatially normalized atlas were analyzed with a neural network segmentation based on a Kohonen Self-Organizing Map. Segmented regions were manually classified to identify the most hyperintense WM region and the normal appearing genu region. Signal intensity differences normalized to the genu within each examination were generated for two time points in 203 children. An unsupervised hierarchical clustering algorithm with the agglomeration method of McQuitty was used to divide data from the first examination into normal appearing or LE groups. A C-support vector machine (C-SVM) was then trained on the first examination data and used to classify the data from the second examination. The overall accuracy of the computer-aided detection tool was 83.5% (299/358) with sensitivity to normal WM of 86.9% (199/229) and specificity to LE of 77.5% (100/129) when compared to the readings of two expert observers. These results suggest that subtle therapy-induced leukoencephalopathy can be objectively and reproducibly detected in children treated for cancer using this computer-aided detection approach based on relative differences in quantitative signal intensity measures normalized within each examination.

Automated diagnosis of autism: in search of a mathematical marker.

PubMed

Bhat, Shreya; Acharya, U Rajendra; Adeli, Hojjat; Bairy, G Muralidhar; Adeli, Amir

2014-01-01

Autism is a type of neurodevelopmental disorder affecting the memory, behavior, emotion, learning ability, and communication of an individual. An early detection of the abnormality, due to irregular processing in the brain, can be achieved using electroencephalograms (EEG). The variations in the EEG signals cannot be deciphered by mere visual inspection. Computer-aided diagnostic tools can be used to recognize the subtle and invisible information present in the irregular EEG pattern and diagnose autism. This paper presents a state-of-the-art review of automated EEG-based diagnosis of autism. Various time domain, frequency domain, time-frequency domain, and nonlinear dynamics for the analysis of autistic EEG signals are described briefly. A focus of the review is the use of nonlinear dynamics and chaos theory to discover the mathematical biomarkers for the diagnosis of the autism analogous to biological markers. A combination of the time-frequency and nonlinear dynamic analysis is the most effective approach to characterize the nonstationary and chaotic physiological signals for the automated EEG-based diagnosis of autism spectrum disorder (ASD). The features extracted using these nonlinear methods can be used as mathematical markers to detect the early stage of autism and aid the clinicians in their diagnosis. This will expedite the administration of appropriate therapies to treat the disorder.

Sequence information signal processor for local and global string comparisons

DOEpatents

Peterson, John C.; Chow, Edward T.; Waterman, Michael S.; Hunkapillar, Timothy J.

1997-01-01

A sequence information signal processing integrated circuit chip designed to perform high speed calculation of a dynamic programming algorithm based upon the algorithm defined by Waterman and Smith. The signal processing chip of the present invention is designed to be a building block of a linear systolic array, the performance of which can be increased by connecting additional sequence information signal processing chips to the array. The chip provides a high speed, low cost linear array processor that can locate highly similar global sequences or segments thereof such as contiguous subsequences from two different DNA or protein sequences. The chip is implemented in a preferred embodiment using CMOS VLSI technology to provide the equivalent of about 400,000 transistors or 100,000 gates. Each chip provides 16 processing elements, and is designed to provide 16 bit, two's compliment operation for maximum score precision of between -32,768 and +32,767. It is designed to provide a comparison between sequences as long as 4,194,304 elements without external software and between sequences of unlimited numbers of elements with the aid of external software. Each sequence can be assigned different deletion and insertion weight functions. Each processor is provided with a similarity measure device which is independently variable. Thus, each processor can contribute to maximum value score calculation using a different similarity measure.

An active learning approach for rapid characterization of endothelial cells in human tumors.

PubMed

Padmanabhan, Raghav K; Somasundar, Vinay H; Griffith, Sandra D; Zhu, Jianliang; Samoyedny, Drew; Tan, Kay See; Hu, Jiahao; Liao, Xuejun; Carin, Lawrence; Yoon, Sam S; Flaherty, Keith T; Dipaola, Robert S; Heitjan, Daniel F; Lal, Priti; Feldman, Michael D; Roysam, Badrinath; Lee, William M F

2014-01-01

Currently, no available pathological or molecular measures of tumor angiogenesis predict response to antiangiogenic therapies used in clinical practice. Recognizing that tumor endothelial cells (EC) and EC activation and survival signaling are the direct targets of these therapies, we sought to develop an automated platform for quantifying activity of critical signaling pathways and other biological events in EC of patient tumors by histopathology. Computer image analysis of EC in highly heterogeneous human tumors by a statistical classifier trained using examples selected by human experts performed poorly due to subjectivity and selection bias. We hypothesized that the analysis can be optimized by a more active process to aid experts in identifying informative training examples. To test this hypothesis, we incorporated a novel active learning (AL) algorithm into FARSIGHT image analysis software that aids the expert by seeking out informative examples for the operator to label. The resulting FARSIGHT-AL system identified EC with specificity and sensitivity consistently greater than 0.9 and outperformed traditional supervised classification algorithms. The system modeled individual operator preferences and generated reproducible results. Using the results of EC classification, we also quantified proliferation (Ki67) and activity in important signal transduction pathways (MAP kinase, STAT3) in immunostained human clear cell renal cell carcinoma and other tumors. FARSIGHT-AL enables characterization of EC in conventionally preserved human tumors in a more automated process suitable for testing and validating in clinical trials. The results of our study support a unique opportunity for quantifying angiogenesis in a manner that can now be tested for its ability to identify novel predictive and response biomarkers.

Structural and Functional Biomedical Imaging Using Polarization-Based Optical Coherence Tomography

NASA Astrophysics Data System (ADS)

Black, Adam J.

Biomedical imaging has had an enormous impact in medicine and research. There are numerous imaging modalities covering a large range of spatial and temporal scales, penetration depths, along with indicators for function and disease. As these imaging technologies mature, the quality of the images they produce increases to resolve finer details with greater contrast at higher speeds which aids in a faster, more accurate diagnosis in the clinic. In this dissertation, polarization-based optical coherence tomography (OCT) systems are used and developed to image biological structure and function with greater speeds, signal-to-noise (SNR) and stability. OCT can image with spatial and temporal resolutions in the micro range. When imaging any sample, feedback is very important to verify the fidelity and desired location on the sample being imaged. To increase frame rates for display as well as data throughput, field-programmable gate arrays (FPGAs) were used with custom algorithms to realize real-time display and streaming output for continuous acquisition of large datasets of swept-source OCT systems. For spectral domain (SD) OCT systems, significant increases in signal-to-noise ratios were achieved from a custom balanced detection (BD) OCT system. The BD system doubled measured signals while reducing common term. For functional imaging, a real-time directed scanner was introduced to visualize the 3D image of a sample to identify regions of interest prior to recording. Elucidating the characteristics of functional OCT signals with the aid of simulations, novel processing methods were also developed to stabilize samples being imaged and identify possible origins of functional signals being measured. Polarization-sensitive OCT was used to image cardiac tissue before and after clearing to identify the regions of vascular perfusion from a coronary artery. The resulting 3D image provides a visualization of the perfusion boundaries for the tissue that would be damaged from a myocardial infarction to possibly identity features that lead to fatal cardiac arrhythmias. 3D functional imaging was used to measure functional retinal activity from a light stimulus. In some cases, single trial responses were possible; measured at the outer segment of the photoreceptor layer. The morphology and time-course of these signals are similar to the intrinsic optical signals reported from phototransduction. Assessing function in the retina could aid in early detection of degenerative diseases of the retina, such as glaucoma and macular degeneration.

The advantages of the surface Laplacian in brain-computer interface research.

PubMed

McFarland, Dennis J

2015-09-01

Brain-computer interface (BCI) systems frequently use signal processing methods, such as spatial filtering, to enhance performance. The surface Laplacian can reduce spatial noise and aid in identification of sources. In BCI research, these two functions of the surface Laplacian correspond to prediction accuracy and signal orthogonality. In the present study, an off-line analysis of data from a sensorimotor rhythm-based BCI task dissociated these functions of the surface Laplacian by comparing nearest-neighbor and next-nearest neighbor Laplacian algorithms. The nearest-neighbor Laplacian produced signals that were more orthogonal while the next-nearest Laplacian produced signals that resulted in better accuracy. Both prediction and signal identification are important for BCI research. Better prediction of user's intent produces increased speed and accuracy of communication and control. Signal identification is important for ruling out the possibility of control by artifacts. Identifying the nature of the control signal is relevant both to understanding exactly what is being studied and in terms of usability for individuals with limited motor control. Copyright © 2014 Elsevier B.V. All rights reserved.

Ultrabroadband phased-array radio frequency (RF) receivers based on optical techniques

NASA Astrophysics Data System (ADS)

Overmiller, Brock M.; Schuetz, Christopher A.; Schneider, Garrett; Murakowski, Janusz; Prather, Dennis W.

2014-03-01

Military operations require the ability to locate and identify electronic emissions in the battlefield environment. However, recent developments in radio detection and ranging (RADAR) and communications technology are making it harder to effectively identify such emissions. Phased array systems aid in discriminating emitters in the scene by virtue of their relatively high-gain beam steering and nulling capabilities. For the purpose of locating emitters, we present an approach realize a broadband receiver based on optical processing techniques applied to the response of detectors in conformal antenna arrays. This approach utilizes photonic techniques that enable us to capture, route, and process the incoming signals. Optical modulators convert the incoming signals up to and exceeding 110 GHz with appreciable conversion efficiency and route these signals via fiber optics to a central processing location. This central processor consists of a closed loop phase control system which compensates for phase fluctuations induced on the fibers due to thermal or acoustic vibrations as well as an optical heterodyne approach for signal conversion down to baseband. Our optical heterodyne approach uses injection-locked paired optical sources to perform heterodyne downconversion/frequency identification of the detected emission. Preliminary geolocation and frequency identification testing of electronic emissions has been performed demonstrating the capabilities of our RF receiver.

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism.

PubMed

Stockley, Peter G; Twarock, Reidun; Bakker, Saskia E; Barker, Amy M; Borodavka, Alexander; Dykeman, Eric; Ford, Robert J; Pearson, Arwen R; Phillips, Simon E V; Ranson, Neil A; Tuma, Roman

2013-03-01

The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process. Previously, it had been thought that this process can be explained entirely by electrostatics. Inspired by recent single-molecule fluorescence experiments that recapitulate the RNA packaging specificity seen in vivo for two model viruses, we present an alternative theory, which recognizes the important cooperative roles played by RNA-coat protein interactions, at sites we have termed packaging signals. The hypothesis is that multiple copies of packaging signals, repeated according to capsid symmetry, aid formation of the required capsid protein conformers at defined positions, resulting in significantly enhanced assembly efficiency. The precise mechanistic roles of packaging signal interactions may vary between viruses, as we have demonstrated for MS2 and STNV. We quantify the impact of packaging signals on capsid assembly efficiency using a dodecahedral model system, showing that heterogeneous affinity distributions of packaging signals for capsid protein out-compete those of homogeneous affinities. These insights pave the way to a new anti-viral therapy, reducing capsid assembly efficiency by targeting of the vital roles of the packaging signals, and opens up new avenues for the efficient construction of protein nanocontainers in bionanotechnology.

Cognitive Spare Capacity as an Index of Listening Effort.

PubMed

Rudner, Mary

2016-01-01

Everyday listening may be experienced as effortful, especially by individuals with hearing loss. This may be due to internal factors, such as cognitive load, and external factors, such as noise. Even when speech is audible, internal and external factors may combine to reduce cognitive spare capacity, or the ability to engage in cognitive processing of spoken information. A better understanding of cognitive spare capacity and how it can be optimally allocated may guide new approaches to rehabilitation and ultimately improve outcomes. This article presents results of three tests of cognitive spare capacity:1. Sentence-final Word Identification and Recall (SWIR) test2. Cognitive Spare Capacity Test (CSCT)3. Auditory Inference Span Test (AIST)Results show that noise reduces cognitive spare capacity even when speech intelligibility is retained. In addition, SWIR results show that hearing aid signal processing can increase cognitive spare capacity, and CSCT and AIST results show that increasing load reduces cognitive spare capacity. Correlational evidence suggests that while the effect of noise on cognitive spare capacity is related to working memory capacity, the effect of load is related to executive function. Future studies should continue to investigate how hearing aid signal processing can mitigate the effect of load on cognitive spare capacity, and whether such effects can be enhanced by developing executive skills through training. The mechanisms modulating cognitive spare capacity should be investigated by studying their neural correlates, and tests of cognitive spare capacity should be developed for clinical use in conjunction with developing new approaches to rehabilitation.

Review of Current Aided/Automatic Target Acquisition Technology for Military Target Acquisition Tasks

DTIC Science & Technology

2011-07-01

radar [e.g., synthetic aperture radar (SAR)]. EO/IR includes multi- and hyperspectral imaging. Signal processing of data from nonimaging sensors, such...enhanced recognition ability. Other nonimage -based techniques, such as category theory,45 hierarchical systems,46 and gradient index flow,47 are possible...the battle- field. There is a plethora of imaging and nonimaging sensors on the battlefield that are being networked together for trans- mission of

Cortical Auditory Evoked Potentials in (Un)aided Normal-Hearing and Hearing-Impaired Adults

PubMed Central

Van Dun, Bram; Kania, Anna; Dillon, Harvey

2016-01-01

Cortical auditory evoked potentials (CAEPs) are influenced by the characteristics of the stimulus, including level and hearing aid gain. Previous studies have measured CAEPs aided and unaided in individuals with normal hearing. There is a significant difference between providing amplification to a person with normal hearing and a person with hearing loss. This study investigated this difference and the effects of stimulus signal-to-noise ratio (SNR) and audibility on the CAEP amplitude in a population with hearing loss. Twelve normal-hearing participants and 12 participants with a hearing loss participated in this study. Three speech sounds—/m/, /g/, and /t/—were presented in the free field. Unaided stimuli were presented at 55, 65, and 75 dB sound pressure level (SPL) and aided stimuli at 55 dB SPL with three different gains in steps of 10 dB. CAEPs were recorded and their amplitudes analyzed. Stimulus SNRs and audibility were determined. No significant effect of stimulus level or hearing aid gain was found in normal hearers. Conversely, a significant effect was found in hearing-impaired individuals. Audibility of the signal, which in some cases is determined by the signal level relative to threshold and in other cases by the SNR, is the dominant factor explaining changes in CAEP amplitude. CAEPs can potentially be used to assess the effects of hearing aid gain in hearing-impaired users. PMID:27587919

Effects of Response Bias and Judgment Framing on Operator Use of an Automated Aid in a Target Detection Task

ERIC Educational Resources Information Center

Rice, Stephen; McCarley, Jason S.

2011-01-01

Automated diagnostic aids prone to false alarms often produce poorer human performance in signal detection tasks than equally reliable miss-prone aids. However, it is not yet clear whether this is attributable to differences in the perceptual salience of the automated aids' misses and false alarms or is the result of inherent differences in…

Effects of Age on Auditory and Cognitive Processing: Implications for Hearing Aid Fitting and Audiologic Rehabilitation

PubMed Central

Pichora-Fuller, M. Kathleen; Singh, Gurjit

2006-01-01

Recent advances in research and clinical practice concerning aging and auditory communication have been driven by questions about age-related differences in peripheral hearing, central auditory processing, and cognitive processing. A “site-of-lesion” view based on anatomic levels inspired research to test competing hypotheses about the contributions of changes at these three levels of the nervous system. A “processing” view based on psychologic functions inspired research to test alternative hypotheses about how lower-level sensory processes and higher-level cognitive processes interact. In the present paper, we suggest that these two views can begin to be unified following the example set by the cognitive neuroscience of aging. The early pioneers of audiology anticipated such a unified view, but today, advances in science and technology make it both possible and necessary. Specifically, we argue that a synthesis of new knowledge concerning the functional neuroscience of auditory cognition is necessary to inform the design and fitting of digital signal processing in “intelligent” hearing devices, as well as to inform best practices for resituating hearing aid fitting in a broader context of audiologic rehabilitation. Long-standing approaches to rehabilitative audiology should be revitalized to emphasize the important role that training and therapy play in promoting compensatory brain reorganization as older adults acclimatize to new technologies. The purpose of the present paper is to provide an integrated framework for understanding how auditory and cognitive processing interact when older adults listen, comprehend, and communicate in realistic situations, to review relevant models and findings, and to suggest how new knowledge about age-related changes in audition and cognition may influence future developments in hearing aid fitting and audiologic rehabilitation. PMID:16528429

Simulink-aided Design and Implementation of Sensorless BLDC Motor Digital Control System

NASA Astrophysics Data System (ADS)

Zhilenkov, A. A.; Tsvetkov, Y. N.; Chistov, V. B.; Nyrkov, A. P.; Sokolov, S. S.

2017-07-01

The paper describes the process of creating of brushless direct current motor’s digital control system. The target motor has no speed sensor, so back-EMF method is used for commutation control. Authors show how to model the control system in MatLab/Simulink and to test it onboard STM32F4 microcontroller.This technology allows to create the most flexible system, which will control possible with a personal computer by communication lines. It is possible to examine the signals in the circuit of the actuator without any external measuring instruments - testers, oscilloscopes, etc. - and output waveforms and measured values of signals directly on the host PC.

Mastication noise reduction method for fully implantable hearing aid using piezo-electric sensor.

PubMed

Na, Sung Dae; Lee, Gihyoun; Wei, Qun; Seong, Ki Woong; Cho, Jin Ho; Kim, Myoung Nam

2017-07-20

Fully implantable hearing devices (FIHDs) can be affected by generated biomechanical noise such as mastication noise. To reduce the mastication noise using a piezo-electric sensor, the mastication noise is measured with the piezo-electric sensor, and noise reduction is practiced by the energy difference. For the experiment on mastication noise, a skull model was designed using artificial skull model and a piezo-electric sensor that can measure the vibration signals better than other sensors. A 1 kHz pure-tone sound through a standard speaker was applied to the model while the lower jawbone of the model was moved in a masticatory fashion. The correlation coefficients and signal-to-noise ratio (SNR) before and after application of the proposed method were compared. It was found that the signal-to-noise ratio and correlation coefficients increased by 4.48 dB and 0.45, respectively. The mastication noise is measured by piezo-electric sensor as the mastication noise that occurred during vibration. In addition, the noise was reduced by using the proposed method in conjunction with MATLAB. In order to confirm the performance of the proposed method, the correlation coefficients and signal-to-noise ratio before and after signal processing were calculated. In the future, an implantable microphone for real-time processing will be developed.

Comparison of single-microphone noise reduction schemes: can hearing impaired listeners tell the difference?

PubMed

Huber, Rainer; Bisitz, Thomas; Gerkmann, Timo; Kiessling, Jürgen; Meister, Hartmut; Kollmeier, Birger

2018-06-01

The perceived qualities of nine different single-microphone noise reduction (SMNR) algorithms were to be evaluated and compared in subjective listening tests with normal hearing and hearing impaired (HI) listeners. Speech samples added with traffic noise or with party noise were processed by the SMNR algorithms. Subjects rated the amount of speech distortions, intrusiveness of background noise, listening effort and overall quality, using a simplified MUSHRA (ITU-R, 2003 ) assessment method. 18 normal hearing and 18 moderately HI subjects participated in the study. Significant differences between the rating behaviours of the two subject groups were observed: While normal hearing subjects clearly differentiated between different SMNR algorithms, HI subjects rated all processed signals very similarly. Moreover, HI subjects rated speech distortions of the unprocessed, noisier signals as being more severe than the distortions of the processed signals, in contrast to normal hearing subjects. It seems harder for HI listeners to distinguish between additive noise and speech distortions or/and they might have a different understanding of the term "speech distortion" than normal hearing listeners have. The findings confirm that the evaluation of SMNR schemes for hearing aids should always involve HI listeners.

Improved EEG Event Classification Using Differential Energy.

PubMed

Harati, A; Golmohammadi, M; Lopez, S; Obeid, I; Picone, J

2015-12-01

Feature extraction for automatic classification of EEG signals typically relies on time frequency representations of the signal. Techniques such as cepstral-based filter banks or wavelets are popular analysis techniques in many signal processing applications including EEG classification. In this paper, we present a comparison of a variety of approaches to estimating and postprocessing features. To further aid in discrimination of periodic signals from aperiodic signals, we add a differential energy term. We evaluate our approaches on the TUH EEG Corpus, which is the largest publicly available EEG corpus and an exceedingly challenging task due to the clinical nature of the data. We demonstrate that a variant of a standard filter bank-based approach, coupled with first and second derivatives, provides a substantial reduction in the overall error rate. The combination of differential energy and derivatives produces a 24 % absolute reduction in the error rate and improves our ability to discriminate between signal events and background noise. This relatively simple approach proves to be comparable to other popular feature extraction approaches such as wavelets, but is much more computationally efficient.

Effect of a Bluetooth-implemented hearing aid on speech recognition performance: subjective and objective measurement.

PubMed

Kim, Min-Beom; Chung, Won-Ho; Choi, Jeesun; Hong, Sung Hwa; Cho, Yang-Sun; Park, Gyuseok; Lee, Sangmin

2014-06-01

The object was to evaluate speech perception improvement through Bluetooth-implemented hearing aids in hearing-impaired adults. Thirty subjects with bilateral symmetric moderate sensorineural hearing loss participated in this study. A Bluetooth-implemented hearing aid was fitted unilaterally in all study subjects. Objective speech recognition score and subjective satisfaction were measured with a Bluetooth-implemented hearing aid to replace the acoustic connection from either a cellular phone or a loudspeaker system. In each system, participants were assigned to 4 conditions: wireless speech signal transmission into hearing aid (wireless mode) in quiet or noisy environment and conventional speech signal transmission using external microphone of hearing aid (conventional mode) in quiet or noisy environment. Also, participants completed questionnaires to investigate subjective satisfaction. Both cellular phone and loudspeaker system situation, participants showed improvements in sentence and word recognition scores with wireless mode compared to conventional mode in both quiet and noise conditions (P < .001). Participants also reported subjective improvements, including better sound quality, less noise interference, and better accuracy naturalness, when using the wireless mode (P < .001). Bluetooth-implemented hearing aids helped to improve subjective and objective speech recognition performances in quiet and noisy environments during the use of electronic audio devices.

Functional Laser Trimming Of Thin Film Resistors On Silicon ICs

NASA Astrophysics Data System (ADS)

Mueller, Michael J.; Mickanin, Wes

1986-07-01

Modern Laser Wafer Trimming (LWT) technology achieves exceptional analog circuit performance and precision while maintain-ing the advantages of high production throughput and yield. Microprocessor-driven instrumentation has both emphasized the role of data conversion circuits and demanded sophisticated signal conditioning functions. Advanced analog semiconductor circuits with bandwidths over 1 GHz, and high precision, trimmable, thin-film resistors meet many of todays emerging circuit requirements. Critical to meeting these requirements are optimum choices of laser characteristics, proper materials, trimming process control, accurate modeling of trimmed resistor performance, and appropriate circuit design. Once limited exclusively to hand-crafted, custom integrated circuits, designs are now available in semi-custom circuit configurations. These are similar to those provided for digital designs and supported by computer-aided design (CAD) tools. Integrated with fully automated measurement and trimming systems, these quality circuits can now be produced in quantity to meet the requirements of communications, instrumentation, and signal processing markets.

33 CFR 67.10-20 - Sound signal tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sound signal tests. 67.10-20... NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for Sound signals § 67.10-20 Sound signal tests. (a) Sound signal tests must: (1) Be made by the applicant in the...

Evaluation of Adaptive Noise Management Technologies for School-Age Children with Hearing Loss.

PubMed

Wolfe, Jace; Duke, Mila; Schafer, Erin; Jones, Christine; Rakita, Lori

2017-05-01

Children with hearing loss experience significant difficulty understanding speech in noisy and reverberant situations. Adaptive noise management technologies, such as fully adaptive directional microphones and digital noise reduction, have the potential to improve communication in noise for children with hearing aids. However, there are no published studies evaluating the potential benefits children receive from the use of adaptive noise management technologies in simulated real-world environments as well as in daily situations. The objective of this study was to compare speech recognition, speech intelligibility ratings (SIRs), and sound preferences of children using hearing aids equipped with and without adaptive noise management technologies. A single-group, repeated measures design was used to evaluate performance differences obtained in four simulated environments. In each simulated environment, participants were tested in a basic listening program with minimal noise management features, a manual program designed for that scene, and the hearing instruments' adaptive operating system that steered hearing instrument parameterization based on the characteristics of the environment. Twelve children with mild to moderately severe sensorineural hearing loss. Speech recognition and SIRs were evaluated in three hearing aid programs with and without noise management technologies across two different test sessions and various listening environments. Also, the participants' perceptual hearing performance in daily real-world listening situations with two of the hearing aid programs was evaluated during a four- to six-week field trial that took place between the two laboratory sessions. On average, the use of adaptive noise management technology improved sentence recognition in noise for speech presented in front of the participant but resulted in a decrement in performance for signals arriving from behind when the participant was facing forward. However, the improvement with adaptive noise management exceeded the decrement obtained when the signal arrived from behind. Most participants reported better subjective SIRs when using adaptive noise management technologies, particularly when the signal of interest arrived from in front of the listener. In addition, most participants reported a preference for the technology with an automatically switching, adaptive directional microphone and adaptive noise reduction in real-world listening situations when compared to conventional, omnidirectional microphone use with minimal noise reduction processing. Use of the adaptive noise management technologies evaluated in this study improves school-age children's speech recognition in noise for signals arriving from the front. Although a small decrement in speech recognition in noise was observed for signals arriving from behind the listener, most participants reported a preference for use of noise management technology both when the signal arrived from in front and from behind the child. The results of this study suggest that adaptive noise management technologies should be considered for use with school-age children when listening in academic and social situations. American Academy of Audiology

Brain signal variability is parametrically modifiable.

PubMed

Garrett, Douglas D; McIntosh, Anthony R; Grady, Cheryl L

2014-11-01

Moment-to-moment brain signal variability is a ubiquitous neural characteristic, yet remains poorly understood. Evidence indicates that heightened signal variability can index and aid efficient neural function, but it is not known whether signal variability responds to precise levels of environmental demand, or instead whether variability is relatively static. Using multivariate modeling of functional magnetic resonance imaging-based parametric face processing data, we show here that within-person signal variability level responds to incremental adjustments in task difficulty, in a manner entirely distinct from results produced by examining mean brain signals. Using mixed modeling, we also linked parametric modulations in signal variability with modulations in task performance. We found that difficulty-related reductions in signal variability predicted reduced accuracy and longer reaction times within-person; mean signal changes were not predictive. We further probed the various differences between signal variance and signal means by examining all voxels, subjects, and conditions; this analysis of over 2 million data points failed to reveal any notable relations between voxel variances and means. Our results suggest that brain signal variability provides a systematic task-driven signal of interest from which we can understand the dynamic function of the human brain, and in a way that mean signals cannot capture. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Digital signal processor and processing method for GPS receivers

NASA Technical Reports Server (NTRS)

Thomas, Jr., Jess B. (Inventor)

1989-01-01

A digital signal processor and processing method therefor for use in receivers of the NAVSTAR/GLOBAL POSITIONING SYSTEM (GPS) employs a digital carrier down-converter, digital code correlator and digital tracking processor. The digital carrier down-converter and code correlator consists of an all-digital, minimum bit implementation that utilizes digital chip and phase advancers, providing exceptional control and accuracy in feedback phase and in feedback delay. Roundoff and commensurability errors can be reduced to extremely small values (e.g., less than 100 nanochips and 100 nanocycles roundoff errors and 0.1 millichip and 1 millicycle commensurability errors). The digital tracking processor bases the fast feedback for phase and for group delay in the C/A, P.sub.1, and P.sub.2 channels on the L.sub.1 C/A carrier phase thereby maintaining lock at lower signal-to-noise ratios, reducing errors in feedback delays, reducing the frequency of cycle slips and in some cases obviating the need for quadrature processing in the P channels. Simple and reliable methods are employed for data bit synchronization, data bit removal and cycle counting. Improved precision in averaged output delay values is provided by carrier-aided data-compression techniques. The signal processor employs purely digital operations in the sense that exactly the same carrier phase and group delay measurements are obtained, to the last decimal place, every time the same sampled data (i.e., exactly the same bits) are processed.

The Function of V-ATPases in Cancer

PubMed Central

Stransky, Laura; Cotter, Kristina

2016-01-01

The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis to proton transport into intracellular compartments and across the plasma membrane. They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the coupled transport of small molecules, as well as such physiological processes as urinary acidification and bone resorption. The V-ATPases have also been implicated in a number of disease processes, including viral infection, renal disease, and bone resorption defects. This review is focused on the growing evidence for the important role of V-ATPases in cancer. This includes functions in cellular signaling (particularly Wnt, Notch, and mTOR signaling), cancer cell survival in the highly acidic environment of tumors, aiding the development of drug resistance, as well as crucial roles in tumor cell invasion, migration, and metastasis. Of greatest excitement is evidence that at least some tumors express isoforms of V-ATPase subunits whose disruption is not lethal, leading to the possibility of developing anti-cancer therapeutics that selectively target V-ATPases that function in cancer cells. PMID:27335445

A quantitative image cytometry technique for time series or population analyses of signaling networks.

PubMed

Ozaki, Yu-ichi; Uda, Shinsuke; Saito, Takeshi H; Chung, Jaehoon; Kubota, Hiroyuki; Kuroda, Shinya

2010-04-01

Modeling of cellular functions on the basis of experimental observation is increasingly common in the field of cellular signaling. However, such modeling requires a large amount of quantitative data of signaling events with high spatio-temporal resolution. A novel technique which allows us to obtain such data is needed for systems biology of cellular signaling. We developed a fully automatable assay technique, termed quantitative image cytometry (QIC), which integrates a quantitative immunostaining technique and a high precision image-processing algorithm for cell identification. With the aid of an automated sample preparation system, this device can quantify protein expression, phosphorylation and localization with subcellular resolution at one-minute intervals. The signaling activities quantified by the assay system showed good correlation with, as well as comparable reproducibility to, western blot analysis. Taking advantage of the high spatio-temporal resolution, we investigated the signaling dynamics of the ERK pathway in PC12 cells. The QIC technique appears as a highly quantitative and versatile technique, which can be a convenient replacement for the most conventional techniques including western blot, flow cytometry and live cell imaging. Thus, the QIC technique can be a powerful tool for investigating the systems biology of cellular signaling.

Quantum-like model of processing of information in the brain based on classical electromagnetic field.

PubMed

Khrennikov, Andrei

2011-09-01

We propose a model of quantum-like (QL) processing of mental information. This model is based on quantum information theory. However, in contrast to models of "quantum physical brain" reducing mental activity (at least at the highest level) to quantum physical phenomena in the brain, our model matches well with the basic neuronal paradigm of the cognitive science. QL information processing is based (surprisingly) on classical electromagnetic signals induced by joint activity of neurons. This novel approach to quantum information is based on representation of quantum mechanics as a version of classical signal theory which was recently elaborated by the author. The brain uses the QL representation (QLR) for working with abstract concepts; concrete images are described by classical information theory. Two processes, classical and QL, are performed parallely. Moreover, information is actively transmitted from one representation to another. A QL concept given in our model by a density operator can generate a variety of concrete images given by temporal realizations of the corresponding (Gaussian) random signal. This signal has the covariance operator coinciding with the density operator encoding the abstract concept under consideration. The presence of various temporal scales in the brain plays the crucial role in creation of QLR in the brain. Moreover, in our model electromagnetic noise produced by neurons is a source of superstrong QL correlations between processes in different spatial domains in the brain; the binding problem is solved on the QL level, but with the aid of the classical background fluctuations. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

BMP Signaling in Astrocytes Downregulates EGFR to Modulate Survival and Maturation

PubMed Central

Scholze, Anja R.; Foo, Lynette C.; Mulinyawe, Sara; Barres, Ben A.

2014-01-01

Astrocytes constitute a major cell population in the brain with a myriad of essential functions, yet we know remarkably little about the signaling pathways and mechanisms that direct astrocyte maturation. To explore the signals regulating astrocyte development, we prospectively purified and cultured immature postnatal rodent astrocytes. We identified fibroblast growth factors (FGFs) and bone morphogenetic proteins (BMPs) as robust trophic factors for immature astrocytes. We showed that astrocytes respond directly to BMPs via phosphorylation of the smad1/5/8 pathway. In vitro, BMP signaling promoted immature astrocytes to adopt multiple characteristics of mature astrocytes, including a more process-bearing morphology, aquaporin-4 (AQP4) and S100β immunoreactivity, limited proliferation, and strong downregulation of epidermal growth factor receptor (EGFR). In vivo, activation of the smad1/5/8 pathway in astrocytes was seen during early postnatal development, but inhibition of astrocyte proliferation was not observed. These insights can aid in the further dissection of the mechanisms and pathways controlling astrocyte biology and development. PMID:25330173

CCD research. [design, fabrication, and applications

NASA Technical Reports Server (NTRS)

Gassaway, J. D.

1976-01-01

The fundamental problems encountered in designing, fabricating, and applying CCD's are reviewed. Investigations are described and results and conclusions are given for the following: (1) the development of design analyses employing computer aided techniques and their application to the design of a grapped structure; (2) the role of CCD's in applications to electronic functions, in particular, signal processing; (3) extending the CCD to silicon films on sapphire (SOS); and (4) all aluminum transfer structure with low noise input-output circuits. Related work on CCD imaging devices is summarized.

Repetition of educational AIDS advertising affects attitudes.

PubMed

Schindler, Simon; Reinhard, Marc-André; Stahlberg, Dagmar

2011-06-01

In educational AIDS campaigns, initiators often use advertisements to warn about the threat of AIDS. The present Internet study (N = 283) tested the assumption of an inverted U-shaped relationship between the number of educational AIDS advertisements in a magazine and the perceived threat of AIDS among different groups (i.e., homosexual men and heterosexual men and women). This expectation was primarily based on signaling theory, which assumes that recipients use repetition frequency as a cue for judgments about the message. Results provided support for the expected inverted U-curve.

How visual cues for when to listen aid selective auditory attention.

PubMed

Varghese, Lenny A; Ozmeral, Erol J; Best, Virginia; Shinn-Cunningham, Barbara G

2012-06-01

Visual cues are known to aid auditory processing when they provide direct information about signal content, as in lip reading. However, some studies hint that visual cues also aid auditory perception by guiding attention to the target in a mixture of similar sounds. The current study directly tests this idea for complex, nonspeech auditory signals, using a visual cue providing only timing information about the target. Listeners were asked to identify a target zebra finch bird song played at a random time within a longer, competing masker. Two different maskers were used: noise and a chorus of competing bird songs. On half of all trials, a visual cue indicated the timing of the target within the masker. For the noise masker, the visual cue did not affect performance when target and masker were from the same location, but improved performance when target and masker were in different locations. In contrast, for the chorus masker, visual cues improved performance only when target and masker were perceived as coming from the same direction. These results suggest that simple visual cues for when to listen improve target identification by enhancing sounds near the threshold of audibility when the target is energetically masked and by enhancing segregation when it is difficult to direct selective attention to the target. Visual cues help little when target and masker already differ in attributes that enable listeners to engage selective auditory attention effectively, including differences in spectrotemporal structure and in perceived location.

Nucleic acid tool enzymes-aided signal amplification strategy for biochemical analysis: status and challenges.

PubMed

Qing, Taiping; He, Dinggeng; He, Xiaoxiao; Wang, Kemin; Xu, Fengzhou; Wen, Li; Shangguan, Jingfang; Mao, Zhengui; Lei, Yanli

2016-04-01

Owing to their highly efficient catalytic effects and substrate specificity, the nucleic acid tool enzymes are applied as 'nano-tools' for manipulating different nucleic acid substrates both in the test-tube and in living organisms. In addition to the function as molecular scissors and molecular glue in genetic engineering, the application of nucleic acid tool enzymes in biochemical analysis has also been extensively developed in the past few decades. Used as amplifying labels for biorecognition events, the nucleic acid tool enzymes are mainly applied in nucleic acids amplification sensing, as well as the amplification sensing of biorelated variations of nucleic acids. With the introduction of aptamers, which can bind different target molecules, the nucleic acid tool enzymes-aided signal amplification strategies can also be used to sense non-nucleic targets (e.g., ions, small molecules, proteins, and cells). This review describes and discusses the amplification strategies of nucleic acid tool enzymes-aided biosensors for biochemical analysis applications. Various analytes, including nucleic acids, ions, small molecules, proteins, and cells, are reviewed briefly. This work also addresses the future trends and outlooks for signal amplification in nucleic acid tool enzymes-aided biosensors.

Intestinal transport and metabolism of bile acids

PubMed Central

Dawson, Paul A.; Karpen, Saul J.

2015-01-01

In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling. PMID:25210150

Imaging calcium sparks in cardiac myocytes.

PubMed

Guatimosim, Silvia; Guatimosim, Cristina; Song, Long-Sheng

2011-01-01

Calcium ions play fundamental roles in many cellular processes in virtually all type of cells. The use of Ca(2+) sensitive fluorescent indicators has proven to be an indispensable tool for studying the spatio-temporal dynamics of intracellular calcium ([Ca(2+)](i)). With the aid of laser scanning confocal microscopy and new generation of Ca(2+) indicators, highly localized, short-lived Ca(2+) signals, namely Ca(2+) sparks, were revealed as elementary Ca(2+) release events during excitation-contraction coupling in cardiomyocytes. Since the discovery of Ca(2+) sparks in 1993, the demonstration of dynamic Ca(2+) micro-domains in living cardiomyocytes has revolutionized our understanding of Ca(2+)-mediated signal transduction in normal and diseased hearts. In this chapter, we have described a commonly used method for recording local and global Ca(2+) signals in cardiomyocytes using the fluorescent indicator fluo-4 acetoxymethyl (AM) and laser scanning confocal microscopy.

Wearable ear EEG for brain interfacing

NASA Astrophysics Data System (ADS)

Schroeder, Eric D.; Walker, Nicholas; Danko, Amanda S.

2017-02-01

Brain-computer interfaces (BCIs) measuring electrical activity via electroencephalogram (EEG) have evolved beyond clinical applications to become wireless consumer products. Typically marketed for meditation and neu- rotherapy, these devices are limited in scope and currently too obtrusive to be a ubiquitous wearable. Stemming from recent advancements made in hearing aid technology, wearables have been shrinking to the point that the necessary sensors, circuitry, and batteries can be fit into a small in-ear wearable device. In this work, an ear-EEG device is created with a novel system for artifact removal and signal interpretation. The small, compact, cost-effective, and discreet device is demonstrated against existing consumer electronics in this space for its signal quality, comfort, and usability. A custom mobile application is developed to process raw EEG from each device and display interpreted data to the user. Artifact removal and signal classification is accomplished via a combination of support matrix machines (SMMs) and soft thresholding of relevant statistical properties.

Mechanisms of Bone Mineralization and Effects of Mechanical Loading

NASA Technical Reports Server (NTRS)

Babich, Michael

1996-01-01

The data suggest that PTH and PKC inhibit nodule formation, and that alternative energy sources are utilized by osteoblasts in the process of mineralization. The conditions and techniques to grow, fix, photograph, and measure bone mineralization in vitro were defined. The results are presently in preliminary form and require further assessment as follows; quantitate the surface area of nodules + treatments via computer-aided image analysis; use PTH + inhibitors of signaling pathways to determine the mechanism of nodule formation; determine how protein kinase C is involved as a promotor of nodule formation; cell proliferation vs. cell death affected by modulation of signal transduction (i.e., PTH, enzyme inhibitors and activators); identify mRNA induced or decreased in response to PTH and signaling modulators that encode proteins that regulate cell morphology, proliferation, and nodule formation. Therefore, several follow-up studies between the laboratories at NASA-Ames Research Center and my laboratory at the University of Illinois have been initiated.

DigiSeis—A software component for digitizing seismic signals using the PC sound card

NASA Astrophysics Data System (ADS)

Amin Khan, Khalid; Akhter, Gulraiz; Ahmad, Zulfiqar

2012-06-01

An innovative software-based approach to develop an inexpensive experimental seismic recorder is presented. This approach requires no hardware as the built-in PC sound card is used for digitization of seismic signals. DigiSeis, an ActiveX component is developed to capture the digitized seismic signals from the sound card and deliver them to applications for processing and display. A seismic recorder application software SeisWave is developed over this component, which provides real-time monitoring and display of seismic events picked by a pair of external geophones. This recorder can be used as an educational aid for conducting seismic experiments. It can also be connected with suitable seismic sensors to record earthquakes. The software application and the ActiveX component are available for download. This component can be used to develop seismic recording applications according to user specific requirements.

Cardiac Care Assistance using Self Configured Sensor Network—a Remote Patient Monitoring System

NASA Astrophysics Data System (ADS)

Sarma Dhulipala, V. R.; Kanagachidambaresan, G. R.

2014-04-01

Pervasive health care systems are used to monitor patients remotely without disturbing the normal day-to-day activities in real-time. Wearable physiological sensors required to monitor various significant ecological parameters of the patients are connected to Body Central Unit (BCU). Body Sensor Network (BSN) updates data in real-time and are designed to transmit alerts against abnormalities which enables quick response by medical units in case of an emergency. BSN helps monitoring patient without any need for attention to the subject. BSN helps in reducing the stress and strain caused by hospital environment. In this paper, mathematical models for heartbeat signal, electro cardio graph (ECG) signal and pulse rate are introduced. These signals are compared and their RMS difference-fast Fourier transforms (PRD-FFT) are processed. In the context of cardiac arrest, alert messages of these parameters and first aid for post-surgical operations has been suggested.

Inhibition of Protein-Protein Interactions and Signaling by Small Molecules

NASA Astrophysics Data System (ADS)

Freire, Ernesto

2010-03-01

Protein-protein interactions are at the core of cell signaling pathways as well as many bacterial and viral infection processes. As such, they define critical targets for drug development against diseases such as cancer, arthritis, obesity, AIDS and many others. Until now, the clinical inhibition of protein-protein interactions and signaling has been accomplished with the use of antibodies or soluble versions of receptor molecules. Small molecule replacements of these therapeutic agents have been extremely difficult to develop; either the necessary potency has been hard to achieve or the expected biological effect has not been obtained. In this presentation, we show that a rigorous thermodynamic approach that combines differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC) provides a unique platform for the identification and optimization of small molecular weight inhibitors of protein-protein interactions. Recent advances in the development of cell entry inhibitors of HIV-1 using this approach will be discussed.

Perceptual Plasticity for Auditory Object Recognition

PubMed Central

Heald, Shannon L. M.; Van Hedger, Stephen C.; Nusbaum, Howard C.

2017-01-01

In our auditory environment, we rarely experience the exact acoustic waveform twice. This is especially true for communicative signals that have meaning for listeners. In speech and music, the acoustic signal changes as a function of the talker (or instrument), speaking (or playing) rate, and room acoustics, to name a few factors. Yet, despite this acoustic variability, we are able to recognize a sentence or melody as the same across various kinds of acoustic inputs and determine meaning based on listening goals, expectations, context, and experience. The recognition process relates acoustic signals to prior experience despite variability in signal-relevant and signal-irrelevant acoustic properties, some of which could be considered as “noise” in service of a recognition goal. However, some acoustic variability, if systematic, is lawful and can be exploited by listeners to aid in recognition. Perceivable changes in systematic variability can herald a need for listeners to reorganize perception and reorient their attention to more immediately signal-relevant cues. This view is not incorporated currently in many extant theories of auditory perception, which traditionally reduce psychological or neural representations of perceptual objects and the processes that act on them to static entities. While this reduction is likely done for the sake of empirical tractability, such a reduction may seriously distort the perceptual process to be modeled. We argue that perceptual representations, as well as the processes underlying perception, are dynamically determined by an interaction between the uncertainty of the auditory signal and constraints of context. This suggests that the process of auditory recognition is highly context-dependent in that the identity of a given auditory object may be intrinsically tied to its preceding context. To argue for the flexible neural and psychological updating of sound-to-meaning mappings across speech and music, we draw upon examples of perceptual categories that are thought to be highly stable. This framework suggests that the process of auditory recognition cannot be divorced from the short-term context in which an auditory object is presented. Implications for auditory category acquisition and extant models of auditory perception, both cognitive and neural, are discussed. PMID:28588524

Change in physiological signals during mindfulness meditation

PubMed Central

Ahani, Asieh; Wahbeh, Helane; Miller, Meghan; Nezamfar, Hooman; Erdogmus, Deniz; Oken, Barry

2014-01-01

Mindfulness meditation (MM) is an inward mental practice, in which a resting but alert state of mind is maintained. MM intervention was performed for a population of older people with high stress levels. This study assessed signal processing methodologies of electroencephalographic (EEG) and respiration signals during meditation and control condition to aid in quantification of the meditative state. EEG and respiration data were collected and analyzed on 34 novice meditators after a 6-week meditation intervention. Collected data were analyzed with spectral analysis and support vector machine classification to evaluate an objective marker for meditation. We observed meditation and control condition differences in the alpha, beta and theta frequency bands. Furthermore, we established a classifier using EEG and respiration signals with a higher accuracy at discriminating between meditation and control conditions than one using the EEG signal only. EEG and respiration based classifier is a viable objective marker for meditation ability. Future studies should quantify different levels of meditation depth and meditation experience using this classifier. Development of an objective physiological meditation marker will allow the mind-body medicine field to advance by strengthening rigor of methods. PMID:24748422

Upset susceptibility study employing circuit analysis and digital simulation

NASA Technical Reports Server (NTRS)

Carreno, V. A.

1984-01-01

This paper describes an approach to predicting the susceptibility of digital systems to signal disturbances. Electrical disturbances on a digital system's input and output lines can be induced by activities and conditions including static electricity, lightning discharge, Electromagnetic Interference (EMI) and Electromagnetic Pulsation (EMP). The electrical signal disturbances employed for the susceptibility study were limited to nondestructive levels, i.e., the system does not sustain partial or total physical damage and reset and/or reload will bring the system to an operational status. The front-end transition from the electrical disturbances to the equivalent digital signals was accomplished by computer-aided circuit analysis. The Super-Sceptre (system for circuit evaluation of transient radiation effects) Program was used. Gate models were developed according to manufacturers' performance specifications and parameters resulting from construction processes characteristic of the technology. Digital simulation at the gate and functional level was employed to determine the impact of the abnormal signals on system performance and to study the propagation characteristics of these signals through the system architecture. Example results are included for an Intel 8080 processor configuration.

Upset susceptibility study employing circuit analysis and digital simulation. [digital systems and electromagnetic interference

NASA Technical Reports Server (NTRS)

Carreno, V. A.

1984-01-01

An approach to predict the susceptibility of digital systems to signal disturbances is described. Electrical disturbances on a digital system's input and output lines can be induced by activities and conditions including static electricity, lightning discharge, electromagnetic interference (EMI), and electromagnetic pulsation (EMP). The electrical signal disturbances employed for the susceptibility study were limited to nondestructive levels, i.e., the system does not sustain partial or total physical damage and reset and/or reload brings the system to an operational status. The front-end transition from the electrical disturbances to the equivalent digital signals was accomplished by computer-aided circuit analysis. The super-sceptre (system for circuit evaluation of transient radiation effects) programs was used. Gate models were developed according to manufacturers' performance specifications and parameters resulting from construction processes characteristic of the technology. Digital simulation at the gate and functional level was employed to determine the impact of the abnormal signals on system performance and to study the propagation characteristics of these signals through the system architecture. Example results are included for an Intel 8080 processor configuration.

Processing of single channel air and water gun data for imaging an impact structure at the Chesapeake Bay

USGS Publications Warehouse

Lee, Myung W.

1999-01-01

Processing of 20 seismic profiles acquired in the Chesapeake Bay area aided in analysis of the details of an impact structure and allowed more accurate mapping of the depression caused by a bolide impact. Particular emphasis was placed on enhancement of seismic reflections from the basement. Application of wavelet deconvolution after a second zero-crossing predictive deconvolution improved the resolution of shallow reflections, and application of a match filter enhanced the basement reflections. The use of deconvolution and match filtering with a two-dimensional signal enhancement technique (F-X filtering) significantly improved the interpretability of seismic sections.

A critical review of hearing-aid single-microphone noise-reduction studies in adults and children.

PubMed

Chong, Foong Yen; Jenstad, Lorienne M

2017-10-26

Single-microphone noise reduction (SMNR) is implemented in hearing aids to suppress background noise. The purpose of this article was to provide a critical review of peer-reviewed studies in adults and children with sensorineural hearing loss who were fitted with hearing aids incorporating SMNR. Articles published between 2000 and 2016 were searched in PUBMED and EBSCO databases. Thirty-two articles were included in the final review. Most studies with adult participants showed that SMNR has no effect on speech intelligibility. Positive results were reported for acceptance of background noise, preference, and listening effort. Studies of school-aged children were consistent with the findings of adult studies. No study with infants or young children of under 5 years old was found. Recent studies on noise-reduction systems not yet available in wearable hearing aids have documented benefits of noise reduction on memory for speech processing for older adults. This evidence supports the use of SMNR for adults and school-aged children when the aim is to improve listening comfort or reduce listening effort. Future research should test SMNR with infants and children who are younger than 5 years of age. Further development, testing, and clinical trials should be carried out on algorithms not yet available in wearable hearing aids. Testing higher cognitive level for speech processing and learning of novel sounds or words could show benefits of advanced signal processing features. These approaches should be expanded to other populations such as children and younger adults. Implications for rehabilitation The review provides a quick reference for students and clinicians regarding the efficacy and effectiveness of SMNR in wearable hearing aids. This information is useful during counseling session to build a realistic expectation among hearing aid users. Most studies in the adult population suggest that SMNR may provide some benefits to adult listeners in terms of listening comfort, acceptance of background noise, and release of cognitive load in a complex listening condition. However, it does not improve speech intelligibility. Studies that examined SMNR in the paediatric population suggest that SMNR may benefit older school-aged children, aged between 10 and 12 years old. The evidence supports the use of SMNR for adults and school-aged children when the aim is to improve listening comfort or reduce listening effort.

The Evolution of Covert Signaling.

PubMed

Smaldino, Paul E; Flamson, Thomas J; McElreath, Richard

2018-03-20

Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberately ambiguous signals: covert signaling. Covert signaling is the transmission of information that is accurately received by its intended audience but obscured when perceived by others. Such signals may allow coordination and enhanced cooperation while also avoiding the alienation or hostile reactions of individuals with different preferences. Although the empirical literature has identified potential mechanisms of covert signaling, such as encryption in humor, there is to date no formal theory of its dynamics. We introduce a novel mathematical model to assess when a covert signaling strategy will evolve, as well as how receiver attitudes coevolve with covert signals. Covert signaling plausibly serves an important function in facilitating within-group cooperative assortment by allowing individuals to pair up with similar group members when possible and to get along with dissimilar ones when necessary. This mechanism has broad implications for theories of signaling and cooperation, humor, social identity, political psychology, and the evolution of human cultural complexity.

Towards Intelligent Interpretation of Low Strain Pile Integrity Testing Results Using Machine Learning Techniques.

PubMed

Cui, De-Mi; Yan, Weizhong; Wang, Xiao-Quan; Lu, Lie-Min

2017-10-25

Low strain pile integrity testing (LSPIT), due to its simplicity and low cost, is one of the most popular NDE methods used in pile foundation construction. While performing LSPIT in the field is generally quite simple and quick, determining the integrity of the test piles by analyzing and interpreting the test signals (reflectograms) is still a manual process performed by experienced experts only. For foundation construction sites where the number of piles to be tested is large, it may take days before the expert can complete interpreting all of the piles and delivering the integrity assessment report. Techniques that can automate test signal interpretation, thus shortening the LSPIT's turnaround time, are of great business value and are in great need. Motivated by this need, in this paper, we develop a computer-aided reflectogram interpretation (CARI) methodology that can interpret a large number of LSPIT signals quickly and consistently. The methodology, built on advanced signal processing and machine learning technologies, can be used to assist the experts in performing both qualitative and quantitative interpretation of LSPIT signals. Specifically, the methodology can ease experts' interpretation burden by screening all test piles quickly and identifying a small number of suspected piles for experts to perform manual, in-depth interpretation. We demonstrate the methodology's effectiveness using the LSPIT signals collected from a number of real-world pile construction sites. The proposed methodology can potentially enhance LSPIT and make it even more efficient and effective in quality control of deep foundation construction.

About Non-Line-Of-Sight Satellite Detection and Exclusion in a 3D Map-Aided Localization Algorithm

PubMed Central

Peyraud, Sébastien; Bétaille, David; Renault, Stéphane; Ortiz, Miguel; Mougel, Florian; Meizel, Dominique; Peyret, François

2013-01-01

Reliable GPS positioning in city environment is a key issue actually, signals are prone to multipath, with poor satellite geometry in many streets. Using a 3D urban model to forecast satellite visibility in urban contexts in order to improve GPS localization is the main topic of the present article. A virtual image processing that detects and eliminates possible faulty measurements is the core of this method. This image is generated using the position estimated a priori by the navigation process itself, under road constraints. This position is then updated by measurements to line-of-sight satellites only. This closed-loop real-time processing has shown very first promising full-scale test results. PMID:23344379

Maintenance Communications for the 1990’s,

DTIC Science & Technology

1983-07-01

reverse aide If necessary and Identify by block n.mber) * -This study details weaknesses in the present maintenance communications system...I. I. STrTAMEr OF NEED: Survivable Maintenance Cacputer System. "- DISCUSSION: The maintenance ccmputer system aids immeasurably in the...GRAVELY, Samuel L. (VAdm, USN-Ret), "Integrated Information Display Systen - A Decision Aid ," Signal, March 1983, p.53-60. GRAVELY, Samuel L. (VAdm, USN

Co-Adaptive Aiding and Automation Enhance Operator Performance

DTIC Science & Technology

2013-03-01

activation system. There is a close relation between physiologically activated adaptive aiding and brain- computer interfaces ( BCI ). BCI here refers...classification of EEG signals (Farwell & Donchin, 1988). Physiologically activated adaptive aiding is, in a sense, a special case of BCI wherein the...as passive BCI , e.g. Zander, Kothe, Jatzev, & 3 Distribution A: Approved for public release; distribution unlimited. 88 ABW Cleared 05/13/2013

Reward Processing, Neuroeconomics, and Psychopathology.

PubMed

Zald, David H; Treadway, Michael T

2017-05-08

Abnormal reward processing is a prominent transdiagnostic feature of psychopathology. The present review provides a framework for considering the different aspects of reward processing and their assessment, and highlights recent insights from the field of neuroeconomics that may aid in understanding these processes. Although altered reward processing in psychopathology has often been treated as a general hypo- or hyperresponsivity to reward, increasing data indicate that a comprehensive understanding of reward dysfunction requires characterization within more specific reward-processing domains, including subjective valuation, discounting, hedonics, reward anticipation and facilitation, and reinforcement learning. As such, more nuanced models of the nature of these abnormalities are needed. We describe several processing abnormalities capable of producing the types of selective alterations in reward-related behavior observed in different forms of psychopathology, including (mal)adaptive scaling and anchoring, dysfunctional weighting of reward and cost variables, competition between valuation systems, and reward prediction error signaling.

Reward Processing, Neuroeconomics, and Psychopathology

PubMed Central

Zald, David H.; Treadway, Michael

2018-01-01

Abnormal reward processing is a prominent transdiagnostic feature of psychopathology. The present review provides a framework for considering the different aspects of reward processing and their assessment and highlight recent insights from the field of neuroeconomics that may aid in understanding these processes. Although altered reward processing in psychopathology has often been treated as a general hypo- or hyper-responsivity to reward, increasing data indicate that a comprehensive understanding of reward dysfunction requires characterization within more specific reward processing domains, including subjective valuation, discounting, hedonics, reward anticipation and facilitation, and reinforcement learning. As such, more nuanced models of the nature of these abnormalities are needed. We describe several processing abnormalities capable of producing the types of selective alterations in reward related behavior observed in different forms of psychopathology, including (mal)adaptive scaling and anchoring, dysfunctional weighting of reward and cost variables, completion between valuation systems, and positive prediction error signaling. PMID:28301764

Performance Analysis of a Hardware Implemented Complex Signal Kurtosis Radio-Frequency Interference Detector

NASA Technical Reports Server (NTRS)

Schoenwald, Adam J.; Bradley, Damon C.; Mohammed, Priscilla N.; Piepmeier, Jeffrey R.; Wong, Mark

2016-01-01

Radio-frequency interference (RFI) is a known problem for passive remote sensing as evidenced in the L-band radiometers SMOS, Aquarius and more recently, SMAP. Various algorithms have been developed and implemented on SMAP to improve science measurements. This was achieved by the use of a digital microwave radiometer. RFI mitigation becomes more challenging for microwave radiometers operating at higher frequencies in shared allocations. At higher frequencies larger bandwidths are also desirable for lower measurement noise further adding to processing challenges. This work focuses on finding improved RFI mitigation techniques that will be effective at additional frequencies and at higher bandwidths. To aid the development and testing of applicable detection and mitigation techniques, a wide-band RFI algorithm testing environment has been developed using the Reconfigurable Open Architecture Computing Hardware System (ROACH) built by the Collaboration for Astronomy Signal Processing and Electronics Research (CASPER) Group. The testing environment also consists of various test equipment used to reproduce typical signals that a radiometer may see including those with and without RFI. The testing environment permits quick evaluations of RFI mitigation algorithms as well as show that they are implementable in hardware. The algorithm implemented is a complex signal kurtosis detector which was modeled and simulated. The complex signal kurtosis detector showed improved performance over the real kurtosis detector under certain conditions. The real kurtosis is implemented on SMAP at 24 MHz bandwidth. The complex signal kurtosis algorithm was then implemented in hardware at 200 MHz bandwidth using the ROACH. In this work, performance of the complex signal kurtosis and the real signal kurtosis are compared. Performance evaluations and comparisons in both simulation as well as experimental hardware implementations were done with the use of receiver operating characteristic (ROC) curves. The complex kurtosis algorithm has the potential to reduce data rate due to onboard processing in addition to improving RFI detection performance.

Minehunting sonar system research and development

NASA Astrophysics Data System (ADS)

Ferguson, Brian

2002-05-01

Sea mines have the potential to threaten the freedom of the seas by disrupting maritime trade and restricting the freedom of maneuver of navies. The acoustic detection, localization, and classification of sea mines involves a sequence of operations starting with the transmission of a sonar pulse and ending with an operator interpreting the information on a sonar display. A recent improvement to the process stems from the application of neural networks to the computed aided detection of sea mines. The advent of ultrawideband sonar transducers together with pulse compression techniques offers a thousandfold increase in the bandwidth-time product of conventional minehunting sonar transmissions enabling stealth mines to be detected at longer ranges. These wideband signals also enable mines to be imaged at safe standoff distances by applying tomographic image reconstruction techniques. The coupling of wideband transducer technology with synthetic aperture processing enhances the resolution of side scan sonars in both the cross-track and along-track directions. The principles on which conventional and advanced minehunting sonars are based are reviewed and the results of applying novel sonar signal processing algorithms to high-frequency sonar data collected in Australian waters are presented.

Impaired auditory temporal selectivity in the inferior colliculus of aged Mongolian gerbils.

PubMed

Khouri, Leila; Lesica, Nicholas A; Grothe, Benedikt

2011-07-06

Aged humans show severe difficulties in temporal auditory processing tasks (e.g., speech recognition in noise, low-frequency sound localization, gap detection). A degradation of auditory function with age is also evident in experimental animals. To investigate age-related changes in temporal processing, we compared extracellular responses to temporally variable pulse trains and human speech in the inferior colliculus of young adult (3 month) and aged (3 years) Mongolian gerbils. We observed a significant decrease of selectivity to the pulse trains in neuronal responses from aged animals. This decrease in selectivity led, on the population level, to an increase in signal correlations and therefore a decrease in heterogeneity of temporal receptive fields and a decreased efficiency in encoding of speech signals. A decrease in selectivity to temporal modulations is consistent with a downregulation of the inhibitory transmitter system in aged animals. These alterations in temporal processing could underlie declines in the aging auditory system, which are unrelated to peripheral hearing loss. These declines cannot be compensated by traditional hearing aids (that rely on amplification of sound) but may rather require pharmacological treatment.

Clustering social cues to determine social signals: developing learning algorithms using the "n-most likely states" approach

NASA Astrophysics Data System (ADS)

Best, Andrew; Kapalo, Katelynn A.; Warta, Samantha F.; Fiore, Stephen M.

2016-05-01

Human-robot teaming largely relies on the ability of machines to respond and relate to human social signals. Prior work in Social Signal Processing has drawn a distinction between social cues (discrete, observable features) and social signals (underlying meaning). For machines to attribute meaning to behavior, they must first understand some probabilistic relationship between the cues presented and the signal conveyed. Using data derived from a study in which participants identified a set of salient social signals in a simulated scenario and indicated the cues related to the perceived signals, we detail a learning algorithm, which clusters social cue observations and defines an "N-Most Likely States" set for each cluster. Since multiple signals may be co-present in a given simulation and a set of social cues often maps to multiple social signals, the "N-Most Likely States" approach provides a dramatic improvement over typical linear classifiers. We find that the target social signal appears in a "3 most-likely signals" set with up to 85% probability. This results in increased speed and accuracy on large amounts of data, which is critical for modeling social cognition mechanisms in robots to facilitate more natural human-robot interaction. These results also demonstrate the utility of such an approach in deployed scenarios where robots need to communicate with human teammates quickly and efficiently. In this paper, we detail our algorithm, comparative results, and offer potential applications for robot social signal detection and machine-aided human social signal detection.

A Signalling Device for Non-Oral Communicators.

ERIC Educational Resources Information Center

King, Thomas W.

1991-01-01

This article describes simple modifications to a basic 9-volt portable transistor radio to serve as a durable, inexpensive signalling device operable by a single external switch. The unit still functions as a radio, but can also help partially speaking students and users of communication aids to signal for help. (Author/PB)

A signal-on electrochemical aptasensor for ultrasensitive detection of endotoxin using three-way DNA junction-aided enzymatic recycling and graphene nanohybrid for amplification

NASA Astrophysics Data System (ADS)

Bai, Lijuan; Chai, Yaqin; Pu, Xiaoyun; Yuan, Ruo

2014-02-01

Endotoxin, also known as lipopolysaccharide (LPS), is able to induce a strong immune response on its internalization into mammalian cells. To date, aptamer-based biosensors for LPS detection have been rarely reported. This work describes a new signal-on electrochemical aptasensor for the ultrasensitive detection of LPS by combining the three-way DNA hybridization process and nanotechnology-based amplification. With the help of DNA1 (associated with the concentration of target LPS), the capture probe hybridizes with DNA1 and the assistant probe to open its hairpin structure and form a ternary ``Y'' junction structure. The DNA1 can be released from the structure in the presence of nicking endonuclease to initiate the next hybridization process. Then a great deal of cleaved capture probe produced in the cyclic process can bind with DNA2-nanocomposite, which contains the electroactive toluidine blue (Tb) with the amplification materials graphene (Gra) and gold nanoparticles (AuNPs). Thus, an enhanced electrochemical signal can be easily read out. With the cascade signal amplification, this newly designed protocol provides an ultrasensitive electrochemical detection of LPS down to the femtogram level (8.7 fg mL-1) with a linear range of 6 orders of magnitude (from 10 fg mL-1 to 50 ng mL-1). Moreover, the high sensitivity and specificity make this method versatile for the detection of other biomolecules by changing the corresponding sequences of the capture probe and the assistant probe.

Aiding the Detection of QRS Complex in ECG Signals by Detecting S Peaks Independently.

PubMed

Sabherwal, Pooja; Singh, Latika; Agrawal, Monika

2018-03-30

In this paper, a novel algorithm for the accurate detection of QRS complex by combining the independent detection of R and S peaks, using fusion algorithm is proposed. R peak detection has been extensively studied and is being used to detect the QRS complex. Whereas, S peaks, which is also part of QRS complex can be independently detected to aid the detection of QRS complex. In this paper, we suggest a method to first estimate S peak from raw ECG signal and then use them to aid the detection of QRS complex. The amplitude of S peak in ECG signal is relatively weak than corresponding R peak, which is traditionally used for the detection of QRS complex, therefore, an appropriate digital filter is designed to enhance the S peaks. These enhanced S peaks are then detected by adaptive thresholding. The algorithm is validated on all the signals of MIT-BIH arrhythmia database and noise stress database taken from physionet.org. The algorithm performs reasonably well even for the signals highly corrupted by noise. The algorithm performance is confirmed by sensitivity and positive predictivity of 99.99% and the detection accuracy of 99.98% for QRS complex detection. The number of false positives and false negatives resulted while analysis has been drastically reduced to 80 and 42 against the 98 and 84 the best results reported so far.

[Principles of energy sources of totally implantable hearing aids for inner ear hearing loss].

PubMed

Baumann, J W; Leysieffer, H

1998-02-01

A fully implantable hearing aid consists of a sound receptor (microphone), an electronic amplifier including active audio-signal processing, an electromechanical transducer (actuator) for stimulating the ear by vibration, and an energy source. The energy source may be either a primary cell or a rechargeable (secondary) cell. As the energy requirements of an implantable hearing aid are dependent on the operating principle of the actuator, the operating principles of electromagnetic and piezoelectric transducers were examined with respect to their relative power consumption. The analysis showed that the energy requirements of an implantable hearing aid are significantly increased when an electromagnetic transducer is used. The power consumption of a piezoelectric transducer was found to be less than that of the electronic components alone. The energy needed to run a fully implantable hearing aid under these conditions would be 38 mWH per day. Primary cells cannot provide the energy needed for a minimum operation time of 5 years (70 WH), and therefore rechargeable cells must be used. A theoretical appraisal was carried out on nickel-cadmium, nickel-metal hydride, and lithium-ion cells to determine their suitability as well as to assess the risks associated with their use in an implant. Safety measures were drawn up from the results. Ni-MH cells were found to be the most suitable for use as an energy source for implantable hearing-aids because they are more robust than Li ion cells and their storage capacity is double that of Ni-Cd cells of similar size.

Performance Analysis of a Hardware Implemented Complex Signal Kurtosis Radio-Frequency Interference Detector

NASA Technical Reports Server (NTRS)

Schoenwald, Adam J.; Bradley, Damon C.; Mohammed, Priscilla N.; Piepmeier, Jeffrey R.; Wong, Mark

2016-01-01

Radio-frequency interference (RFI) is a known problem for passive remote sensing as evidenced in the L-band radiometers SMOS, Aquarius and more recently, SMAP. Various algorithms have been developed and implemented on SMAP to improve science measurements. This was achieved by the use of a digital microwave radiometer. RFI mitigation becomes more challenging for microwave radiometers operating at higher frequencies in shared allocations. At higher frequencies larger bandwidths are also desirable for lower measurement noise further adding to processing challenges. This work focuses on finding improved RFI mitigation techniques that will be effective at additional frequencies and at higher bandwidths. To aid the development and testing of applicable detection and mitigation techniques, a wide-band RFI algorithm testing environment has been developed using the Reconfigurable Open Architecture Computing Hardware System (ROACH) built by the Collaboration for Astronomy Signal Processing and Electronics Research (CASPER) Group. The testing environment also consists of various test equipment used to reproduce typical signals that a radiometer may see including those with and without RFI. The testing environment permits quick evaluations of RFI mitigation algorithms as well as show that they are implementable in hardware. The algorithm implemented is a complex signal kurtosis detector which was modeled and simulated. The complex signal kurtosis detector showed improved performance over the real kurtosis detector under certain conditions. The real kurtosis is implemented on SMAP at 24 MHz bandwidth. The complex signal kurtosis algorithm was then implemented in hardware at 200 MHz bandwidth using the ROACH. In this work, performance of the complex signal kurtosis and the real signal kurtosis are compared. Performance evaluations and comparisons in both simulation as well as experimental hardware implementations were done with the use of receiver operating characteristic (ROC) curves.

Perception of Hearing Aid-Processed Speech in Individuals with Late-Onset Auditory Neuropathy Spectrum Disorder.

PubMed

Mathai, Jijo Pottackal; Appu, Sabarish

2015-01-01

Auditory neuropathy spectrum disorder (ANSD) is a form of sensorineural hearing loss, causing severe deficits in speech perception. The perceptual problems of individuals with ANSD were attributed to their temporal processing impairment rather than to reduced audibility. This rendered their rehabilitation difficult using hearing aids. Although hearing aids can restore audibility, compression circuits in a hearing aid might distort the temporal modulations of speech, causing poor aided performance. Therefore, hearing aid settings that preserve the temporal modulations of speech might be an effective way to improve speech perception in ANSD. The purpose of the study was to investigate the perception of hearing aid-processed speech in individuals with late-onset ANSD. A repeated measures design was used to study the effect of various compression time settings on speech perception and perceived quality. Seventeen individuals with late-onset ANSD within the age range of 20-35 yr participated in the study. The word recognition scores (WRSs) and quality judgment of phonemically balanced words, processed using four different compression settings of a hearing aid (slow, medium, fast, and linear), were evaluated. The modulation spectra of hearing aid-processed stimuli were estimated to probe the effect of amplification on the temporal envelope of speech. Repeated measures analysis of variance and post hoc Bonferroni's pairwise comparisons were used to analyze the word recognition performance and quality judgment. The comparison between unprocessed and all four hearing aid-processed stimuli showed significantly higher perception using the former stimuli. Even though perception of words processed using slow compression time settings of the hearing aids were significantly higher than the fast one, their difference was only 4%. In addition, there were no significant differences in perception between any other hearing aid-processed stimuli. Analysis of the temporal envelope of hearing aid-processed stimuli revealed minimal changes in the temporal envelope across the four hearing aid settings. In terms of quality, the highest number of individuals preferred stimuli processed using slow compression time settings. Individuals who preferred medium ones followed this. However, none of the individuals preferred fast compression time settings. Analysis of quality judgment showed that slow, medium, and linear settings presented significantly higher preference scores than the fast compression setting. Individuals with ANSD showed no marked difference in perception of speech that was processed using the four different hearing aid settings. However, significantly higher preference, in terms of quality, was found for stimuli processed using slow, medium, and linear settings over the fast one. Therefore, whenever hearing aids are recommended for ANSD, those having slow compression time settings or linear amplification may be chosen over the fast (syllabic compression) one. In addition, WRSs obtained using hearing aid-processed stimuli were remarkably poorer than unprocessed stimuli. This shows that processing of speech through hearing aids might have caused a large reduction of performance in individuals with ANSD. However, further evaluation is needed using individually programmed hearing aids rather than hearing aid-processed stimuli. American Academy of Audiology.

High area rate reconnaissance (HARR) and mine reconnaissance/hunter (MR/H) exploratory development programs

NASA Astrophysics Data System (ADS)

Lathrop, John D.

1995-06-01

This paper describes the sea mine countermeasures developmental context, technology goals, and progress to date of the two principal Office of Naval Research exploratory development programs addressing sea mine reconnaissance and minehunting technology development. The first of these programs, High Area Rate Reconnaissance, is developing toroidal volume search sonar technology, sidelooking sonar technology, and associated signal processing technologies (motion compensation, beamforming, and computer-aided detection and classification) for reconnaissance and hunting against volume mines and proud bottom mines from 21-inch diameter vehicles operating in deeper waters. The second of these programs, Amphibious Operation Area Mine Reconnaissance/Hunter, is developing a suite of sensor technologies (synthetic aperture sonar, ahead-looking sonar, superconducting magnetic field gradiometer, and electro-optic sensor) and associated signal processing technologies for reconnaissance and hunting against all mine types (including buried mines) in shallow water and very shallow water from 21-inch diameter vehicles. The technologies under development by these two programs must provide excellent capabilities for mine detection, mine classification, and discrimination against false targets.

All-digital signal-processing open-loop fiber-optic gyroscope with enlarged dynamic range.

PubMed

Wang, Qin; Yang, Chuanchuan; Wang, Xinyue; Wang, Ziyu

2013-12-15

We propose and realize a new open-loop fiber-optic gyroscope (FOG) with an all-digital signal-processing (DSP) system where an all-digital phase-locked loop is employed for digital demodulation to eliminate the variation of the source intensity and suppress the bias drift. A Sagnac phase-shift tracking method is proposed to enlarge the dynamic range, and, with its aid, a new open-loop FOG, which can achieve a large dynamic range and high sensitivity at the same time, is realized. The experimental results show that compared with the conventional open-loop FOG with the same fiber coil and optical devices, the proposed FOG reduces the bias instability from 0.259 to 0.018 deg/h, and the angle random walk from 0.031 to 0.006 deg/h(1/2), moreover, enlarges the dynamic range to ±360 deg/s, exceeding the maximum dynamic range ±63 deg/s of the conventional open-loop FOG.

Biomedical application of wavelets: analysis of electroencephalograph signals for monitoring depth of anesthesia

NASA Astrophysics Data System (ADS)

Abbate, Agostino; Nayak, A.; Koay, J.; Roy, R. J.; Das, Pankaj K.

1996-03-01

The wavelet transform (WT) has been used to study the nonstationary information in the electroencephalograph (EEG) as an aid in determining the anesthetic depth. A complex analytic mother wavelet is utilized to obtain the time evolution of the various spectral components of the EEG signal. The technique is utilized for the detection and spectral analysis of transient and background processes in the awake and asleep states. It can be observed that the response of both states before the application of the stimulus is similar in amplitude but not in spectral contents, which suggests a background activity of the brain. The brain reacts to the external stimulus in two different modes depending on the state of consciousness of the subject. In the case of awake state, there is an evident increase in response, while for the sleep state a reduction in this activity is observed. This analysis seems to suggest that the brain has an ongoing background process that monitors external stimulus in both the sleep and awake states.

Detecting Disease in Radiographs with Intuitive Confidence

PubMed Central

2015-01-01

This paper argues in favor of a specific type of confidence for use in computer-aided diagnosis and disease classification, namely, sine/cosine values of angles represented by points on the unit circle. The paper shows how this confidence is motivated by Chinese medicine and how sine/cosine values are directly related with the two forces Yin and Yang. The angle for which sine and cosine are equal (45°) represents the state of equilibrium between Yin and Yang, which is a state of nonduality that indicates neither normality nor abnormality in terms of disease classification. The paper claims that the proposed confidence is intuitive and can be readily understood by physicians. The paper underpins this thesis with theoretical results in neural signal processing, stating that a sine/cosine relationship between the actual input signal and the perceived (learned) input is key to neural learning processes. As a practical example, the paper shows how to use the proposed confidence values to highlight manifestations of tuberculosis in frontal chest X-rays. PMID:26495433

Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine.

PubMed

Chen, Wen Li Kelly; Simmons, Craig A

2011-04-30

Diseased tissues are noted for their compromised mechanical properties, which contribute to organ failure; regeneration entails restoration of tissue structure and thereby functions. Thus, the physical signature of a tissue is closely associated with its biological function. In this review, we consider a mechanics-centric view of disease and regeneration by drawing parallels between in vivo tissue-level observations and corroborative cellular evidence in vitro to demonstrate the importance of the mechanical stiffness of the extracellular matrix in these processes. This is not intended to devalue the importance of biochemical signaling; in fact, as we discuss, many mechanical stiffness-driven processes not only require cooperation with biochemical cues, but they ultimately converge at common signaling cascades to influence cell and tissue function in an integrative manner. The study of how physical and biochemical signals collectively modulate cell function not only brings forth a more holistic understanding of cell (patho)biology, but it also creates opportunities to control material properties to improve culture platforms for research and drug screening and aid in the rationale design of biomaterials for molecular therapy and tissue engineering applications. Copyright © 2011 Elsevier B.V. All rights reserved.

A fuzzy decision tree for fault classification.

PubMed

Zio, Enrico; Baraldi, Piero; Popescu, Irina C

2008-02-01

In plant accident management, the control room operators are required to identify the causes of the accident, based on the different patterns of evolution of the monitored process variables thereby developing. This task is often quite challenging, given the large number of process parameters monitored and the intense emotional states under which it is performed. To aid the operators, various techniques of fault classification have been engineered. An important requirement for their practical application is the physical interpretability of the relationships among the process variables underpinning the fault classification. In this view, the present work propounds a fuzzy approach to fault classification, which relies on fuzzy if-then rules inferred from the clustering of available preclassified signal data, which are then organized in a logical and transparent decision tree structure. The advantages offered by the proposed approach are precisely that a transparent fault classification model is mined out of the signal data and that the underlying physical relationships among the process variables are easily interpretable as linguistic if-then rules that can be explicitly visualized in the decision tree structure. The approach is applied to a case study regarding the classification of simulated faults in the feedwater system of a boiling water reactor.

Computational analyses of spectral trees from electrospray multi-stage mass spectrometry to aid metabolite identification.

PubMed

Cao, Mingshu; Fraser, Karl; Rasmussen, Susanne

2013-10-31

Mass spectrometry coupled with chromatography has become the major technical platform in metabolomics. Aided by peak detection algorithms, the detected signals are characterized by mass-over-charge ratio (m/z) and retention time. Chemical identities often remain elusive for the majority of the signals. Multi-stage mass spectrometry based on electrospray ionization (ESI) allows collision-induced dissociation (CID) fragmentation of selected precursor ions. These fragment ions can assist in structural inference for metabolites of low molecular weight. Computational investigations of fragmentation spectra have increasingly received attention in metabolomics and various public databases house such data. We have developed an R package "iontree" that can capture, store and analyze MS2 and MS3 mass spectral data from high throughput metabolomics experiments. The package includes functions for ion tree construction, an algorithm (distMS2) for MS2 spectral comparison, and tools for building platform-independent ion tree (MS2/MS3) libraries. We have demonstrated the utilization of the package for the systematic analysis and annotation of fragmentation spectra collected in various metabolomics platforms, including direct infusion mass spectrometry, and liquid chromatography coupled with either low resolution or high resolution mass spectrometry. Assisted by the developed computational tools, we have demonstrated that spectral trees can provide informative evidence complementary to retention time and accurate mass to aid with annotating unknown peaks. These experimental spectral trees once subjected to a quality control process, can be used for querying public MS2 databases or de novo interpretation. The putatively annotated spectral trees can be readily incorporated into reference libraries for routine identification of metabolites.

Detecting fast and thermal neutrons with a boron loaded liquid scintillator, EJ-339A.

PubMed

Pino, F; Stevanato, L; Cester, D; Nebbia, G; Sajo-Bohus, L; Viesti, G

2014-09-01

A commercial boron-loaded liquid scintillator EJ-339 A was studied, using a (252)Cf source with/without polyethylene moderator, to examine the possibility of discriminating slow-neutron induced events in (10)B from fast-neutron events, resulting from proton recoils, and gamma-ray events. Despite the strong light quenching associated with neutron induced events in (10)B, correct classification of these events is shown to be possible with the aid of digital signal processing. Copyright © 2014 Elsevier Ltd. All rights reserved.

Voice technology and BBN

NASA Technical Reports Server (NTRS)

Wolf, Jared J.

1977-01-01

The following research was discussed: (1) speech signal processing; (2) automatic speech recognition; (3) continuous speech understanding; (4) speaker recognition; (5) speech compression; (6) subjective and objective evaluation of speech communication system; (7) measurement of the intelligibility and quality of speech when degraded by noise or other masking stimuli; (8) speech synthesis; (9) instructional aids for second-language learning and for training of the deaf; and (10) investigation of speech correlates of psychological stress. Experimental psychology, control systems, and human factors engineering, which are often relevant to the proper design and operation of speech systems are described.

Stuart Gatehouse: The International Perspective

PubMed Central

Van Tasell, Dianne J.; Levitt, Harry

2008-01-01

The international contributions of Stuart Gatehouse are reviewed in three areas: as a scientist, as an advisor to health policy makers, and as a participant in international conferences. He was able, as no other auditory scientist of his time, to bridge the gap between scientific and clinical research. His ability to apply sound scientific principles to issues of clinical importance was most apparent in his work in three main areas of his research: acclimatization to amplified speech, auditory disability and hearing aid benefit, and candidature for linear and nonlinear signal processing. PMID:18567589

Computer aided design of digital controller for radial active magnetic bearings

NASA Technical Reports Server (NTRS)

Cai, Zhong; Shen, Zupei; Zhang, Zuming; Zhao, Hongbin

1992-01-01

A five degree of freedom Active Magnetic Bearing (AMB) system is developed which is controlled by digital controllers. The model of the radial AMB system is linearized and the state equation is derived. Based on the state variables feedback theory, digital controllers are designed. The performance of the controllers are evaluated according to experimental results. The Computer Aided Design (CAD) method is used to design controllers for magnetic bearings. The controllers are implemented with a digital signal processing (DSP) system. The control algorithms are realized with real-time programs. It is very easy to change the controller by changing or modifying the programs. In order to identify the dynamic parameters of the controlled magnetic system, a special experiment was carried out. Also, the online Recursive Least Squares (RLS) parameter identification method is studied. It can be realized with the digital controllers. Online parameter identification is essential for the realization of an adaptive controller.

Parameter optimization of flux-aided backing-submerged arc welding by using Taguchi method

NASA Astrophysics Data System (ADS)

Pu, Juan; Yu, Shengfu; Li, Yuanyuan

2017-07-01

Flux-aided backing-submerged arc welding has been conducted on D36 steel with thickness of 20 mm. The effects of processing parameters such as welding current, voltage, welding speed and groove angle on welding quality were investigated by Taguchi method. The optimal welding parameters were predicted and the individual importance of each parameter on welding quality was evaluated by examining the signal-to-noise ratio and analysis of variance (ANOVA) results. The importance order of the welding parameters for the welding quality of weld bead was: welding current > welding speed > groove angle > welding voltage. The welding quality of weld bead increased gradually with increasing welding current and welding speed and decreasing groove angle. The optimum values of the welding current, welding speed, groove angle and welding voltage were found to be 1050 A, 27 cm/min, 40∘ and 34 V, respectively.

Fundamentals handbook of electrical and computer engineering. Volume 1 Circuits fields and electronics

NASA Astrophysics Data System (ADS)

Chang, S. S. L.

State of the art technology in circuits, fields, and electronics is discussed. The principles and applications of these technologies to industry, digital processing, microwave semiconductors, and computer-aided design are explained. Important concepts and methodologies in mathematics and physics are reviewed, and basic engineering sciences and associated design methods are dealt with, including: circuit theory and the design of magnetic circuits and active filter synthesis; digital signal processing, including FIR and IIR digital filter design; transmission lines, electromagnetic wave propagation and surface acoustic wave devices. Also considered are: electronics technologies, including power electronics, microwave semiconductors, GaAs devices, and magnetic bubble memories; digital circuits and logic design.

Deep convolutional neural network for the automated detection and diagnosis of seizure using EEG signals.

PubMed

Acharya, U Rajendra; Oh, Shu Lih; Hagiwara, Yuki; Tan, Jen Hong; Adeli, Hojjat

2017-09-27

An encephalogram (EEG) is a commonly used ancillary test to aide in the diagnosis of epilepsy. The EEG signal contains information about the electrical activity of the brain. Traditionally, neurologists employ direct visual inspection to identify epileptiform abnormalities. This technique can be time-consuming, limited by technical artifact, provides variable results secondary to reader expertise level, and is limited in identifying abnormalities. Therefore, it is essential to develop a computer-aided diagnosis (CAD) system to automatically distinguish the class of these EEG signals using machine learning techniques. This is the first study to employ the convolutional neural network (CNN) for analysis of EEG signals. In this work, a 13-layer deep convolutional neural network (CNN) algorithm is implemented to detect normal, preictal, and seizure classes. The proposed technique achieved an accuracy, specificity, and sensitivity of 88.67%, 90.00% and 95.00%, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

Collective Cellular Decision-Making Gives Developmental Plasticity: A Model of Signaling in Branching Roots

NASA Astrophysics Data System (ADS)

McCleery, W. Tyler; Mohd-Radzman, Nadiatul A.; Grieneisen, Veronica A.

Cells within tissues can be regarded as autonomous entities that respond to their local environment and signaling from neighbors. Cell coordination is particularly important in plants, where root architecture must strategically invest resources for growth to optimize nutrient acquisition. Thus, root cells are constantly adapting to environmental cues and neighbor communication in a non-linear manner. To explain such plasticity, we view the root as a swarm of coupled multi-cellular structures, ''metamers'', rather than as a continuum of identical cells. These metamers are individually programmed to achieve a local objective - developing a lateral root primordia, which aids in local foraging of nutrients. Collectively, such individual attempts may be halted, structuring root architecture as an emergent behavior. Each metamer's decision to branch is coordinated locally and globally through hormone signaling, including processes of controlled diffusion, active polar transport, and dynamic feedback. We present a physical model of the signaling mechanism that coordinates branching decisions in response to the environment. This work was funded by the European Commission 7th Framework Program, Project No. 601062, SWARM-ORGAN.

δ-Generalized Labeled Multi-Bernoulli Filter Using Amplitude Information of Neighboring Cells

PubMed Central

Liu, Chao; Lei, Peng; Qi, Yaolong

2018-01-01

The amplitude information (AI) of echoed signals plays an important role in radar target detection and tracking. A lot of research shows that the introduction of AI enables the tracking algorithm to distinguish targets from clutter better and then improves the performance of data association. The current AI-aided tracking algorithms only consider the signal amplitude in the range-azimuth cell where measurement exists. However, since radar echoes always contain backscattered signals from multiple cells, the useful information of neighboring cells would be lost if directly applying those existing methods. In order to solve this issue, a new δ-generalized labeled multi-Bernoulli (δ-GLMB) filter is proposed. It exploits the AI of radar echoes from neighboring cells to construct a united amplitude likelihood ratio, and then plugs it into the update process and the measurement-track assignment cost matrix of the δ-GLMB filter. Simulation results show that the proposed approach has better performance in target’s state and number estimation than that of the δ-GLMB only using single-cell AI in low signal-to-clutter-ratio (SCR) environment. PMID:29642595

Modeling the isotopic evolution of snowpack and snowmelt: Testing a spatially distributed parsimonious approach.

PubMed

Ala-Aho, Pertti; Tetzlaff, Doerthe; McNamara, James P; Laudon, Hjalmar; Kormos, Patrick; Soulsby, Chris

2017-07-01

Use of stable water isotopes has become increasingly popular in quantifying water flow paths and travel times in hydrological systems using tracer-aided modeling. In snow-influenced catchments, snowmelt produces a traceable isotopic signal, which differs from original snowfall isotopic composition because of isotopic fractionation in the snowpack. These fractionation processes in snow are relatively well understood, but representing their spatiotemporal variability in tracer-aided studies remains a challenge. We present a novel, parsimonious modeling method to account for the snowpack isotope fractionation and estimate isotope ratios in snowmelt water in a fully spatially distributed manner. Our model introduces two calibration parameters that alone account for the isotopic fractionation caused by sublimation from interception and ground snow storage, and snowmelt fractionation progressively enriching the snowmelt runoff. The isotope routines are linked to a generic process-based snow interception-accumulation-melt model facilitating simulation of spatially distributed snowmelt runoff. We use a synthetic modeling experiment to demonstrate the functionality of the model algorithms in different landscape locations and under different canopy characteristics. We also provide a proof-of-concept model test and successfully reproduce isotopic ratios in snowmelt runoff sampled with snowmelt lysimeters in two long-term experimental catchment with contrasting winter conditions. To our knowledge, the method is the first such tool to allow estimation of the spatially distributed nature of isotopic fractionation in snowpacks and the resulting isotope ratios in snowmelt runoff. The method can thus provide a useful tool for tracer-aided modeling to better understand the integrated nature of flow, mixing, and transport processes in snow-influenced catchments.

Ocean Basin Impact of Ambient Noise on Marine Mammal Detectability, Distribution, and Acoustic Communication - YIP

DTIC Science & Technology

2011-09-30

when applying the 4 passive sonar equation. The integration of acoustic time series from different ocean basins will provide a synoptic...Penn State ARL Hydrophone Analog signal (V) Preamplifiers & 24-bit AiD 1-100 HzBP filter Signal Flow for a Single Hydrophone Digital signal

75 FR 998 - Terminate Long Range Aids to Navigation (Loran-C) Signal

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... to Navigation (Loran-C) Signal AGENCY: U.S. Coast Guard, DHS. ACTION: Notice. SUMMARY: On October 28... Act allows for the termination of the Loran-C system subject to the Coast Guard certifying that termination of the Loran-C signal will not adversely impact the safety of maritime navigation and the...

Wireless photoplethysmographic device for heart rate variability signal acquisition and analysis.

PubMed

Reyes, Ivan; Nazeran, Homer; Franco, Mario; Haltiwanger, Emily

2012-01-01

The photoplethysmographic (PPG) signal has the potential to aid in the acquisition and analysis of heart rate variability (HRV) signal: a non-invasive quantitative marker of the autonomic nervous system that could be used to assess cardiac health and other physiologic conditions. A low-power wireless PPG device was custom-developed to monitor, acquire and analyze the arterial pulse in the finger. The system consisted of an optical sensor to detect arterial pulse as variations in reflected light intensity, signal conditioning circuitry to process the reflected light signal, a microcontroller to control PPG signal acquisition, digitization and wireless transmission, a receiver to collect the transmitted digital data and convert them back to their analog representations. A personal computer was used to further process the captured PPG signals and display them. A MATLAB program was then developed to capture the PPG data, detect the RR peaks, perform spectral analysis of the PPG data, and extract the HRV signal. A user-friendly graphical user interface (GUI) was developed in LabView to display the PPG data and their spectra. The performance of each module (sensing unit, signal conditioning, wireless transmission/reception units, and graphical user interface) was assessed individually and the device was then tested as a whole. Consequently, PPG data were obtained from five healthy individuals to test the utility of the wireless system. The device was able to reliably acquire the PPG signals from the volunteers. To validate the accuracy of the MATLAB codes, RR peak information from each subject was fed into Kubios software as a text file. Kubios was able to generate a report sheet with the time domain and frequency domain parameters of the acquired data. These features were then compared against those calculated by MATLAB. The preliminary results demonstrate that the prototype wireless device could be used to perform HRV signal acquisition and analysis.

The proactive brain and the fate of dead hypotheses

PubMed Central

Tal, Amir; Bar, Moshe

2014-01-01

A substantial portion of information flow in the brain is directed top-down, from high processing areas downwards. Signals of this sort are regarded as conveying prior expectations, biasing the processing and eventual perception of incoming stimuli. In this perspective we describe a framework of top-down processing in the visual system in which predictions on the identity of objects in sight aid in their recognition. Focus is placed, in particular, on a relatively uncharted ramification of this framework, that of the fate of initial predictions that are eventually rejected during the process of selection. We propose that such predictions are rapidly inhibited in the brain after a competing option has been selected. Empirical support, along with behavioral, neuronal and computational aspects of this proposal are discussed, and future directions for related research are offered. PMID:25408645

The proactive brain and the fate of dead hypotheses.

PubMed

Tal, Amir; Bar, Moshe

2014-01-01

A substantial portion of information flow in the brain is directed top-down, from high processing areas downwards. Signals of this sort are regarded as conveying prior expectations, biasing the processing and eventual perception of incoming stimuli. In this perspective we describe a framework of top-down processing in the visual system in which predictions on the identity of objects in sight aid in their recognition. Focus is placed, in particular, on a relatively uncharted ramification of this framework, that of the fate of initial predictions that are eventually rejected during the process of selection. We propose that such predictions are rapidly inhibited in the brain after a competing option has been selected. Empirical support, along with behavioral, neuronal and computational aspects of this proposal are discussed, and future directions for related research are offered.

Enhanced detection of a low-frequency signal by using broad squeezed light and a bichromatic local oscillator

NASA Astrophysics Data System (ADS)

Li, Wei; Jin, Yuanbin; Yu, Xudong; Zhang, Jing

2017-08-01

We experimentally study a protocol of using the broadband high-frequency squeezed vacuum to detect the low-frequency signal. In this scheme, the lower sideband field of the squeezed light carries the low-frequency modulation signal, and the two strong coherent light fields are applied as the bichromatic local oscillator in the homodyne detection to measure the quantum entanglement of the upper and lower sideband for the broadband squeezed light. The power of one of the local oscillators for detecting the upper sideband can be adjusted to optimize the conditional variance in the low-frequency regime by subtracting the photocurrent of the upper sideband field of the squeezed light from that of the lower sideband field. By means of the quantum correlation of the upper and lower sideband for the broadband squeezed light, the low-frequency signal beyond the standard quantum limit is measured. This scheme is appropriate for enhancing the sensitivity of the low-frequency signal by the aid of the broad squeezed light, such as gravitational waves detection, and does not need to directly produce the low-frequency squeezing in an optical parametric process.

Generation and Repair of AID-initiated DNA Lesions in B Lymphocytes

PubMed Central

Chen, Zhangguo; Wang, Jing H.

2014-01-01

Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions. PMID:24748462

Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling.

PubMed

Roggero, R; Robert-Hebmann, V; Harrington, S; Roland, J; Vergne, L; Jaleco, S; Devaux, C; Biard-Piechaczyk, M

2001-08-01

Apoptosis of CD4(+) T lymphocytes, induced by contact between human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120) and its receptors, could contribute to the cell depletion observed in HIV-infected individuals. CXCR4 appears to play an important role in gp120-induced cell death, but the mechanisms involved in this apoptotic process remain poorly understood. To get insight into the signal transduction pathways connecting CXCR4 to apoptosis following gp120 binding, we used different cell lines expressing wild-type CXCR4 and a truncated form of CD4 that binds gp120 but lacks the ability to transduce signals. The present study demonstrates that (i) the interaction of cell-associated gp120 with CXCR4-expressing target cells triggers a rapid dissipation of the mitochondrial transmembrane potential resulting in the cytosolic release of cytochrome c from the mitochondria to cytosol, concurrent with activation of caspase-9 and -3; (ii) this apoptotic process is independent of Fas signaling; and (iii) cooperation with a CD4 signal is not required. In addition, following coculture with cells expressing gp120, a Fas-independent apoptosis involving mitochondria and caspase activation is also observed in primary umbilical cord blood CD4(+) T lymphocytes expressing high levels of CXCR4. Thus, this gp120-mediated apoptotic pathway may contribute to CD4(+) T-cell depletion in AIDS.

Binding of Human Immunodeficiency Virus Type 1 gp120 to CXCR4 Induces Mitochondrial Transmembrane Depolarization and Cytochrome c-Mediated Apoptosis Independently of Fas Signaling

PubMed Central

Roggero, Rodolphe; Robert-Hebmann, Véronique; Harrington, Steve; Roland, Joachim; Vergne, Laurence; Jaleco, Sara; Devaux, Christian; Biard-Piechaczyk, Martine

2001-01-01

Apoptosis of CD4+ T lymphocytes, induced by contact between human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120) and its receptors, could contribute to the cell depletion observed in HIV-infected individuals. CXCR4 appears to play an important role in gp120-induced cell death, but the mechanisms involved in this apoptotic process remain poorly understood. To get insight into the signal transduction pathways connecting CXCR4 to apoptosis following gp120 binding, we used different cell lines expressing wild-type CXCR4 and a truncated form of CD4 that binds gp120 but lacks the ability to transduce signals. The present study demonstrates that (i) the interaction of cell-associated gp120 with CXCR4-expressing target cells triggers a rapid dissipation of the mitochondrial transmembrane potential resulting in the cytosolic release of cytochrome c from the mitochondria to cytosol, concurrent with activation of caspase-9 and -3; (ii) this apoptotic process is independent of Fas signaling; and (iii) cooperation with a CD4 signal is not required. In addition, following coculture with cells expressing gp120, a Fas-independent apoptosis involving mitochondria and caspase activation is also observed in primary umbilical cord blood CD4+ T lymphocytes expressing high levels of CXCR4. Thus, this gp120-mediated apoptotic pathway may contribute to CD4+ T-cell depletion in AIDS. PMID:11462036

Towards Intelligent Interpretation of Low Strain Pile Integrity Testing Results Using Machine Learning Techniques

PubMed Central

Cui, De-Mi; Wang, Xiao-Quan; Lu, Lie-Min

2017-01-01

Low strain pile integrity testing (LSPIT), due to its simplicity and low cost, is one of the most popular NDE methods used in pile foundation construction. While performing LSPIT in the field is generally quite simple and quick, determining the integrity of the test piles by analyzing and interpreting the test signals (reflectograms) is still a manual process performed by experienced experts only. For foundation construction sites where the number of piles to be tested is large, it may take days before the expert can complete interpreting all of the piles and delivering the integrity assessment report. Techniques that can automate test signal interpretation, thus shortening the LSPIT’s turnaround time, are of great business value and are in great need. Motivated by this need, in this paper, we develop a computer-aided reflectogram interpretation (CARI) methodology that can interpret a large number of LSPIT signals quickly and consistently. The methodology, built on advanced signal processing and machine learning technologies, can be used to assist the experts in performing both qualitative and quantitative interpretation of LSPIT signals. Specifically, the methodology can ease experts’ interpretation burden by screening all test piles quickly and identifying a small number of suspected piles for experts to perform manual, in-depth interpretation. We demonstrate the methodology’s effectiveness using the LSPIT signals collected from a number of real-world pile construction sites. The proposed methodology can potentially enhance LSPIT and make it even more efficient and effective in quality control of deep foundation construction. PMID:29068431

Software/hardware distributed processing network supporting the Ada environment

NASA Astrophysics Data System (ADS)

Wood, Richard J.; Pryk, Zen

1993-09-01

A high-performance, fault-tolerant, distributed network has been developed, tested, and demonstrated. The network is based on the MIPS Computer Systems, Inc. R3000 Risc for processing, VHSIC ASICs for high speed, reliable, inter-node communications and compatible commercial memory and I/O boards. The network is an evolution of the Advanced Onboard Signal Processor (AOSP) architecture. It supports Ada application software with an Ada- implemented operating system. A six-node implementation (capable of expansion up to 256 nodes) of the RISC multiprocessor architecture provides 120 MIPS of scalar throughput, 96 Mbytes of RAM and 24 Mbytes of non-volatile memory. The network provides for all ground processing applications, has merit for space-qualified RISC-based network, and interfaces to advanced Computer Aided Software Engineering (CASE) tools for application software development.

Research on Frequency Transposition for Hearing Aids. Final Report.

ERIC Educational Resources Information Center

Gengel, Roy W.; Pickett, J. M.

Reported were studies measuring residual auditory capacities of deaf persons and investigating hearing aids which transpose speech to lower frequencies where deaf persons may have better hearing. Studies on temporal and frequency discrimination indicated that the duration of a signal may have a differential effect on its detectability by…

Performance Standards in Need-Based Student Aid

ERIC Educational Resources Information Center

Scott-Clayton, Judith; Schudde, Lauren

2016-01-01

College attendance is a risky investment. But students may not recognize when they are at risk for failure, and financial aid introduces the possibility for moral hazard. Academic performance standards can serve three roles in this context: signaling expectations for success, providing incentives for increased student effort, and limiting…

33 CFR 67.40-5 - Waivers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... sound signal have been modified or waived, constitutes a hazard to marine navigation, he or she is... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Waivers. 67.40-5 Section 67.40-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO...

33 CFR 67.40-5 - Waivers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... sound signal have been modified or waived, constitutes a hazard to marine navigation, he or she is... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Waivers. 67.40-5 Section 67.40-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO...

Identification of musical instruments by normal-hearing subjects listening through a cochlear-implant simulation

NASA Astrophysics Data System (ADS)

Reich, Rebecca D.; Eddington, Donald

2002-05-01

Signal processing in a cochlear implant (CI) is primarily designed to convey speech and environmental sounds, and can cause distortion of musical timbre. Systematic investigation of musical instrument identification through a CI has not yet revealed how timbre is affected by the implant's processing. In this experiment, the bandpass filtering, rectification, and low-pass filtering of an implant are simulated in MATLAB. Synthesized signals representing 12 common instruments, each performing a major scale, are processed by simulations using up to 8 analysis channels. The unprocessed recordings, together with the 8 simulation conditions for 12 instruments, are presented in random order to each of the subjects. The subject's task is to identify the instrument represented by each item. The subjects also subjectively score each item based on similarity and pleasantness. We anticipate performance using the simulation will be worse than the unprocessed condition because of the limited information delivered by the envelopes of the analysis channels. These results will be analyzed as a confusion matrix and provide a basis for contrasting the information used by subjects listening to the unprocessed and processed materials. Understanding these differences should aid in the development of new processing strategies to better represent music for cochlear implant users.

Long-range acoustic observations of the Eyjafjallajökull eruption, Iceland, April-May 2010

NASA Astrophysics Data System (ADS)

Matoza, Robin S.; Vergoz, Julien; Le Pichon, Alexis; Ceranna, Lars; Green, David N.; Evers, Läslo G.; Ripepe, Maurizio; Campus, Paola; Liszka, Ludwik; Kvaerna, Tormod; Kjartansson, Einar; Höskuldsson, Ármann

2011-03-01

The April-May 2010 summit eruption of Eyjafjallajökull, Iceland, was recorded by 14 atmospheric infrasound sensor arrays at ranges between 1,700 and 3,700 km, indicating that infrasound from modest-size eruptions can propagate for thousands of kilometers in atmospheric waveguides. Although variations in both atmospheric propagation conditions and background noise levels at the sensors generate fluctuations in signal-to-noise ratios and signal detectability, array processing techniques successfully discriminate between volcanic infrasound and ambient coherent and incoherent noise. The current global infrasound network is significantly more dense and sensitive than any previously operated network and signals from large volcanic explosions are routinely recorded. Because volcanic infrasound is generated during the explosive release of fluid into the atmosphere, it is a strong indicator that an eruption has occurred. Therefore, long-range infrasonic monitoring may aid volcanic explosion detection by complementing other monitoring technologies, especially in remote regions with sparse ground-based instrument networks.

High-resolution time-frequency representation of EEG data using multi-scale wavelets

NASA Astrophysics Data System (ADS)

Li, Yang; Cui, Wei-Gang; Luo, Mei-Lin; Li, Ke; Wang, Lina

2017-09-01

An efficient time-varying autoregressive (TVAR) modelling scheme that expands the time-varying parameters onto the multi-scale wavelet basis functions is presented for modelling nonstationary signals and with applications to time-frequency analysis (TFA) of electroencephalogram (EEG) signals. In the new parametric modelling framework, the time-dependent parameters of the TVAR model are locally represented by using a novel multi-scale wavelet decomposition scheme, which can allow the capability to capture the smooth trends as well as track the abrupt changes of time-varying parameters simultaneously. A forward orthogonal least square (FOLS) algorithm aided by mutual information criteria are then applied for sparse model term selection and parameter estimation. Two simulation examples illustrate that the performance of the proposed multi-scale wavelet basis functions outperforms the only single-scale wavelet basis functions or Kalman filter algorithm for many nonstationary processes. Furthermore, an application of the proposed method to a real EEG signal demonstrates the new approach can provide highly time-dependent spectral resolution capability.

Modeling borehole microseismic and strain signals measured by a distributed fiber optic sensor

NASA Astrophysics Data System (ADS)

Mellors, R. J.; Sherman, C. S.; Ryerson, F. J.; Morris, J.; Allen, G. S.; Messerly, M. J.; Carr, T.; Kavousi, P.

2017-12-01

The advent of distributed fiber optic sensors installed in boreholes provides a new and data-rich perspective on the subsurface environment. This includes the long-term capability for vertical seismic profiles, monitoring of active borehole processes such as well stimulation, and measuring of microseismic signals. The distributed fiber sensor, which measures strain (or strain-rate), is an active sensor with highest sensitivity parallel to the fiber and subject to varying types of noise, both external and internal. We take a systems approach and include the response of the electronics, fiber/cable, and subsurface to improve interpretation of the signals. This aids in understanding noise sources, assessing error bounds on amplitudes, and developing appropriate algorithms for improving the image. Ultimately, a robust understanding will allow identification of areas for future improvement and possible optimization in fiber and cable design. The subsurface signals are simulated in two ways: 1) a massively parallel multi-physics code that is capable of modeling hydraulic stimulation of heterogeneous reservoir with a pre-existing discrete fracture network, and 2) a parallelized 3D finite difference code for high-frequency seismic signals. Geometry and parameters for the simulations are derived from fiber deployments, including the Marcellus Shale Energy and Environment Laboratory (MSEEL) project in West Virginia. The combination mimics both the low-frequency strain signals generated during the fracture process and high-frequency signals from microseismic and perforation shots. Results are compared with available fiber data and demonstrate that quantitative interpretation of the fiber data provides valuable constraints on the fracture geometry and microseismic activity. These constraints appear difficult, if not impossible, to obtain otherwise.

Tolerable hearing-aid delays: IV. effects on subjective disturbance during speech production by hearing-impaired subjects.

PubMed

Stone, Michael A; Moore, Brian C J

2005-04-01

We assessed the effects of time delay in a hearing aid on subjective disturbance and reading rates while the user of the aid was speaking, using hearing-impaired subjects and real-time processing. The time delay was constant across frequency. A digital signal processor was programmed as a four-channel, fast-acting, wide-dynamic-range compression hearing aid. One of four delays could be selected on the aid to produce a total delay of 13, 21, 30, or 40 msec between microphone and receiver. Twenty-five subjects, mostly with near-symmetric hearing impairment of cochlear origin, were fitted bilaterally with behind-the-ear aids connected to the processor. The aids were programmed with insertion gains prescribed by the CAMEQ loudness equalization procedure for each subject and ear. Subjects were asked to read aloud from scripts: speech production rates were measured and subjective ratings of the disturbance of the delay were obtained. Subjects required some training to recognize the effects of the delay to rate it consistently. Subjective disturbance increased progressively with increasing delay and was a nonmonotonic function of low-frequency hearing loss. Subjects with mild or severe low-frequency hearing loss were generally less disturbed by the delay than those with moderate loss. Disturbance ratings tended to decrease over successive tests. Word production rates were not significantly affected by delay over the range of delays tested. The results follow a pattern similar to those presented in , obtained using a simulation of hearing loss and normally hearing subjects, except for the nonmonotonic variation of disturbance with low-frequency hearing loss. We hypothesize that disturbance is maximal when the levels in the ear canal of the low-frequency components are similar for the unaided and aided sounds. A rating of 3, which is probably just acceptable, was obtained for delays ranging from 14 to 30 msec, depending on the hearing loss. Some acclimatization to the subjective disturbance occurred over a time scale of about 1 hour.

Financial Aid Administrators' Views on Simplifying Financial Aid: NASFAA's 2008 Financial Aid Simplification Survey Report

ERIC Educational Resources Information Center

National Association of Student Financial Aid Administrators (NJ1), 2008

2008-01-01

Despite a decade of simplification efforts, students and families are often still baffled by the student aid process and cringe at the sight of financial aid application forms. Contrary to its purpose of helping students to access college, the student aid application process causes families frustration and confusion that has been cited as an…

Real-time Enhancement, Registration, and Fusion for a Multi-Sensor Enhanced Vision System

NASA Technical Reports Server (NTRS)

Hines, Glenn D.; Rahman, Zia-ur; Jobson, Daniel J.; Woodell, Glenn A.

2006-01-01

Over the last few years NASA Langley Research Center (LaRC) has been developing an Enhanced Vision System (EVS) to aid pilots while flying in poor visibility conditions. The EVS captures imagery using two infrared video cameras. The cameras are placed in an enclosure that is mounted and flown forward-looking underneath the NASA LaRC ARIES 757 aircraft. The data streams from the cameras are processed in real-time and displayed on monitors on-board the aircraft. With proper processing the camera system can provide better-than- human-observed imagery particularly during poor visibility conditions. However, to obtain this goal requires several different stages of processing including enhancement, registration, and fusion, and specialized processing hardware for real-time performance. We are using a real-time implementation of the Retinex algorithm for image enhancement, affine transformations for registration, and weighted sums to perform fusion. All of the algorithms are executed on a single TI DM642 digital signal processor (DSP) clocked at 720 MHz. The image processing components were added to the EVS system, tested, and demonstrated during flight tests in August and September of 2005. In this paper we briefly discuss the EVS image processing hardware and algorithms. We then discuss implementation issues and show examples of the results obtained during flight tests. Keywords: enhanced vision system, image enhancement, retinex, digital signal processing, sensor fusion

Joint Carrier-Phase Synchronization and LDPC Decoding

NASA Technical Reports Server (NTRS)

Simon, Marvin; Valles, Esteban

2009-01-01

A method has been proposed to increase the degree of synchronization of a radio receiver with the phase of a suppressed carrier signal modulated with a binary- phase-shift-keying (BPSK) or quaternary- phase-shift-keying (QPSK) signal representing a low-density parity-check (LDPC) code. This method is an extended version of the method described in Using LDPC Code Constraints to Aid Recovery of Symbol Timing (NPO-43112), NASA Tech Briefs, Vol. 32, No. 10 (October 2008), page 54. Both methods and the receiver architectures in which they would be implemented belong to a class of timing- recovery methods and corresponding receiver architectures characterized as pilotless in that they do not require transmission and reception of pilot signals. The proposed method calls for the use of what is known in the art as soft decision feedback to remove the modulation from a replica of the incoming signal prior to feeding this replica to a phase-locked loop (PLL) or other carrier-tracking stage in the receiver. Soft decision feedback refers to suitably processed versions of intermediate results of iterative computations involved in the LDPC decoding process. Unlike a related prior method in which hard decision feedback (the final sequence of decoded symbols) is used to remove the modulation, the proposed method does not require estimation of the decoder error probability. In a basic digital implementation of the proposed method, the incoming signal (having carrier phase theta theta (sub c) plus noise would first be converted to inphase (I) and quadrature (Q) baseband signals by mixing it with I and Q signals at the carrier frequency [wc/(2 pi)] generated by a local oscillator. The resulting demodulated signals would be processed through one-symbol-period integrate and- dump filters, the outputs of which would be sampled and held, then multiplied by a soft-decision version of the baseband modulated signal. The resulting I and Q products consist of terms proportional to the cosine and sine of the carrier phase cc as well as correlated noise components. These products would be fed as inputs to a digital PLL that would include a number-controlled oscillator (NCO), which provides an estimate of the carrier phase, theta(sub c).

Analog Computer-Aided Detection (CAD) information can be more effective than binary marks.

PubMed

Cunningham, Corbin A; Drew, Trafton; Wolfe, Jeremy M

2017-02-01

In socially important visual search tasks, such as baggage screening and diagnostic radiology, experts miss more targets than is desirable. Computer-aided detection (CAD) programs have been developed specifically to improve performance in these professional search tasks. For example, in breast cancer screening, many CAD systems are capable of detecting approximately 90% of breast cancer, with approximately 0.5 false-positive detections per image. Nevertheless, benefits of CAD in clinical settings tend to be small (Birdwell, 2009) or even absent (Meziane et al., 2011; Philpotts, 2009). The marks made by a CAD system can be "binary," giving the same signal to any location where the signal is above some threshold. Alternatively, a CAD system presents an analog signal that reflects strength of the signal at a location. In the experiments reported, we compare analog and binary CAD presentations using nonexpert observers and artificial stimuli defined by two noisy signals: a visible color signal and an "invisible" signal that informed our simulated CAD system. We found that analog CAD generally yielded better overall performance than binary CAD. The analog benefit is similar at high and low target prevalence. Our data suggest that the form of the CAD signal can directly influence performance. Analog CAD may allow the computer to be more helpful to the searcher.

Objective Quality and Intelligibility Prediction for Users of Assistive Listening Devices

PubMed Central

Falk, Tiago H.; Parsa, Vijay; Santos, João F.; Arehart, Kathryn; Hazrati, Oldooz; Huber, Rainer; Kates, James M.; Scollie, Susan

2015-01-01

This article presents an overview of twelve existing objective speech quality and intelligibility prediction tools. Two classes of algorithms are presented, namely intrusive and non-intrusive, with the former requiring the use of a reference signal, while the latter does not. Investigated metrics include both those developed for normal hearing listeners, as well as those tailored particularly for hearing impaired (HI) listeners who are users of assistive listening devices (i.e., hearing aids, HAs, and cochlear implants, CIs). Representative examples of those optimized for HI listeners include the speech-to-reverberation modulation energy ratio, tailored to hearing aids (SRMR-HA) and to cochlear implants (SRMR-CI); the modulation spectrum area (ModA); the hearing aid speech quality (HASQI) and perception indices (HASPI); and the PErception MOdel - hearing impairment quality (PEMO-Q-HI). The objective metrics are tested on three subjectively-rated speech datasets covering reverberation-alone, noise-alone, and reverberation-plus-noise degradation conditions, as well as degradations resultant from nonlinear frequency compression and different speech enhancement strategies. The advantages and limitations of each measure are highlighted and recommendations are given for suggested uses of the different tools under specific environmental and processing conditions. PMID:26052190

'Low-hanging fruit': counting and accounting for children in PEPFAR-funded HIV/AIDS programmes in South Africa.

PubMed

Reynolds, Lindsey J

2014-01-01

The article traces the social life of a policy that aimed to define and circumscribe the ambiguous and contested category of 'orphaned and vulnerable children' (or OVC) in South Africa at the height of the 'emergency response' to HIV/AIDS. Drawing on several months of institutional ethnographic research conducted over the course of five years with South African organisations receiving funding from the US President's Emergency Plan for AIDS Relief to provide services to 'OVC', the project interrogates the influence of governmental forms of counting and accounting on health policy and practice in South Africa. Focusing on the experiences of one organisation, the article describes a process of policy 'translation' typified by a series of disconnects between the intentions of a policy and the exigencies of implementation, structured by the ambiguous and flexible nature of the 'OVC' category. In this context, the article argues that the uncertainty produced by the implementation of the guidelines was not simply an artefact of a poorly designed policy, but rather signals an underlying epistemological tension in the practice of 'global health', in which quantitative metrics designed for monitoring and evaluation are often incapable of approximating the complexities of everyday life.

Kalman Orbit Optimized Loop Tracking

NASA Technical Reports Server (NTRS)

Young, Lawrence E.; Meehan, Thomas K.

2011-01-01

Under certain conditions of low signal power and/or high noise, there is insufficient signal to noise ratio (SNR) to close tracking loops with individual signals on orbiting Global Navigation Satellite System (GNSS) receivers. In addition, the processing power available from flight computers is not great enough to implement a conventional ultra-tight coupling tracking loop. This work provides a method to track GNSS signals at very low SNR without the penalty of requiring very high processor throughput to calculate the loop parameters. The Kalman Orbit-Optimized Loop (KOOL) tracking approach constitutes a filter with a dynamic model and using the aggregate of information from all tracked GNSS signals to close the tracking loop for each signal. For applications where there is not a good dynamic model, such as very low orbits where atmospheric drag models may not be adequate to achieve the required accuracy, aiding from an IMU (inertial measurement unit) or other sensor will be added. The KOOL approach is based on research JPL has done to allow signal recovery from weak and scintillating signals observed during the use of GPS signals for limb sounding of the Earth s atmosphere. That approach uses the onboard PVT (position, velocity, time) solution to generate predictions for the range, range rate, and acceleration of the low-SNR signal. The low- SNR signal data are captured by a directed open loop. KOOL builds on the previous open loop tracking by including feedback and observable generation from the weak-signal channels so that the MSR receiver will continue to track and provide PVT, range, and Doppler data, even when all channels have low SNR.

Performance Standards in Need-Based Student Aid. A CAPSEE Working Paper

ERIC Educational Resources Information Center

Scott-Clayton, Judith; Schudde, Lauren

2016-01-01

College attendance is a risky investment. But students may not recognize when they are at risk for failure, and financial aid introduces the possibility for moral hazard. Academic performance standards can serve three roles in this context: signaling expectations for success, providing incentives for increased student effort, and limiting…

Recent Shifts on Aid by Elite Colleges Signal New Push To Help the Middle Class.

ERIC Educational Resources Information Center

Gose, Ben

1998-01-01

Several elite private colleges have announced additional financial aid sources for middle class students, because enrollment patterns suggested previous policies attracted proportionately more low- and high-income than middle-income students. One college feels the new policy encourages families to save for college. Critics say the institutions are…

Music and hearing aids--an introduction.

PubMed

Chasin, Marshall

2012-09-01

Modern digital hearing aids have provided improved fidelity over those of earlier decades for speech. The same however cannot be said for music. Most modern hearing aids have a limitation of their "front end," which comprises the analog-to-digital (A/D) converter. For a number of reasons, the spectral nature of music as an input to a hearing aid is beyond the optimal operating conditions of the "front end" components. Amplified music tends to be of rather poor fidelity. Once the music signal is distorted, no amount of software manipulation that occurs later in the circuitry can improve things. The solution is not a software issue. Some characteristics of music that make it difficult to be transduced without significant distortion include an increased sound level relative to that of speech, and the crest factor- the difference in dB between the instantaneous peak of a signal and its RMS value. Clinical strategies and technical innovations have helped to improve the fidelity of amplified music and these include a reduction of the level of the input that is presented to the A/D converter.

Visuospatial Asymmetries Arise from Differences in the Onset Time of Perceptual Evidence Accumulation.

PubMed

Newman, Daniel P; Loughnane, Gerard M; Kelly, Simon P; O'Connell, Redmond G; Bellgrove, Mark A

2017-03-22

Healthy subjects tend to exhibit a bias of visual attention whereby left hemifield stimuli are processed more quickly and accurately than stimuli appearing in the right hemifield. It has long been held that this phenomenon arises from the dominant role of the right cerebral hemisphere in regulating attention. However, methods that would enable more precise understanding of the mechanisms underpinning visuospatial bias have remained elusive. We sought to finely trace the temporal evolution of spatial biases by leveraging a novel bilateral dot motion detection paradigm. In combination with electroencephalography, this paradigm enables researchers to isolate discrete neural signals reflecting the key neural processes needed for making these detection decisions. These include signals for spatial attention, early target selection, evidence accumulation, and motor preparation. Using this method, we established that three key neural markers accounted for unique between-subject variation in visuospatial bias: hemispheric asymmetry in posterior α power measured before target onset, which is related to the distribution of preparatory attention across the visual field; asymmetry in the peak latency of the early N2c target-selection signal; and, finally, asymmetry in the onset time of the subsequent neural evidence-accumulation process with earlier onsets for left hemifield targets. Our development of a single paradigm to dissociate distinct processing components that track the temporal evolution of spatial biases not only advances our understanding of the neural mechanisms underpinning normal visuospatial attention bias, but may also in the future aid differential diagnoses in disorders of spatial attention. SIGNIFICANCE STATEMENT The significance of this research is twofold. First, it shows that individual differences in how humans direct their attention between left and right space reflects physiological differences in how early the brain starts to accumulate evidence for the existence of a visual target. Second, the novel methods developed here may have particular relevance to disorders of attention, such as unilateral spatial neglect. In the case of spatial neglect, pathological inattention to left space could have multiple underlying causes, including biased attention, impaired decision formation, or a motor deficit related to one side of space. Our development of a single paradigm to dissociate each of these components may aid in supporting more precise differential diagnosis in such heterogeneous disorders. Copyright © 2017 the authors 0270-6474/17/373378-08$15.00/0.

NHDOT : process for municipally managed state aid highway program projects

DOT National Transportation Integrated Search

2006-05-23

The design and construction of Municipally Managed State Aid Highway Program projects must comply with the requirements in this guideline in order to receive State Aid under the applicable provisions of RSA 235. Under this process, State Aid Construc...

Mobility and orientation aid for blind persons using artificial vision

NASA Astrophysics Data System (ADS)

Costa, Gustavo; Gusberti, Adrián; Graffigna, Juan Pablo; Guzzo, Martín; Nasisi, Oscar

2007-11-01

Blind or vision-impaired persons are limited in their normal life activities. Mobility and orientation of blind persons is an ever-present research subject because no total solution has yet been reached for these activities that pose certain risks for the affected persons. The current work presents the design and development of a device conceived on capturing environment information through stereoscopic vision. The images captured by a couple of video cameras are transferred and processed by configurable and sequential FPGA and DSP devices that issue action signals to a tactile feedback system. Optimal processing algorithms are implemented to perform this feedback in real time. The components selected permit portability; that is, to readily get used to wearing the device.

An Efficient Moving Target Detection Algorithm Based on Sparsity-Aware Spectrum Estimation

PubMed Central

Shen, Mingwei; Wang, Jie; Wu, Di; Zhu, Daiyin

2014-01-01

In this paper, an efficient direct data domain space-time adaptive processing (STAP) algorithm for moving targets detection is proposed, which is achieved based on the distinct spectrum features of clutter and target signals in the angle-Doppler domain. To reduce the computational complexity, the high-resolution angle-Doppler spectrum is obtained by finding the sparsest coefficients in the angle domain using the reduced-dimension data within each Doppler bin. Moreover, we will then present a knowledge-aided block-size detection algorithm that can discriminate between the moving targets and the clutter based on the extracted spectrum features. The feasibility and effectiveness of the proposed method are validated through both numerical simulations and raw data processing results. PMID:25222035

Blind estimation of reverberation time

NASA Astrophysics Data System (ADS)

Ratnam, Rama; Jones, Douglas L.; Wheeler, Bruce C.; O'Brien, William D.; Lansing, Charissa R.; Feng, Albert S.

2003-11-01

The reverberation time (RT) is an important parameter for characterizing the quality of an auditory space. Sounds in reverberant environments are subject to coloration. This affects speech intelligibility and sound localization. Many state-of-the-art audio signal processing algorithms, for example in hearing-aids and telephony, are expected to have the ability to characterize the listening environment, and turn on an appropriate processing strategy accordingly. Thus, a method for characterization of room RT based on passively received microphone signals represents an important enabling technology. Current RT estimators, such as Schroeder's method, depend on a controlled sound source, and thus cannot produce an online, blind RT estimate. Here, a method for estimating RT without prior knowledge of sound sources or room geometry is presented. The diffusive tail of reverberation was modeled as an exponentially damped Gaussian white noise process. The time-constant of the decay, which provided a measure of the RT, was estimated using a maximum-likelihood procedure. The estimates were obtained continuously, and an order-statistics filter was used to extract the most likely RT from the accumulated estimates. The procedure was illustrated for connected speech. Results obtained for simulated and real room data are in good agreement with the real RT values.

Online estimation of room reverberation time

NASA Astrophysics Data System (ADS)

Ratnam, Rama; Jones, Douglas L.; Wheeler, Bruce C.; Feng, Albert S.

2003-04-01

The reverberation time (RT) is an important parameter for characterizing the quality of an auditory space. Sounds in reverberant environments are subject to coloration. This affects speech intelligibility and sound localization. State-of-the-art signal processing algorithms for hearing aids are expected to have the ability to evaluate the characteristics of the listening environment and turn on an appropriate processing strategy accordingly. Thus, a method for the characterization of room RT based on passively received microphone signals represents an important enabling technology. Current RT estimators, such as Schroeder's method or regression, depend on a controlled sound source, and thus cannot produce an online, blind RT estimate. Here, we describe a method for estimating RT without prior knowledge of sound sources or room geometry. The diffusive tail of reverberation was modeled as an exponentially damped Gaussian white noise process. The time constant of the decay, which provided a measure of the RT, was estimated using a maximum-likelihood procedure. The estimates were obtained continuously, and an order-statistics filter was used to extract the most likely RT from the accumulated estimates. The procedure was illustrated for connected speech. Results obtained for simulated and real room data are in good agreement with the real RT values.

Using a signal cancellation technique to assess adaptive directivity of hearing aids.

PubMed

Wu, Yu-Hsiang; Bentler, Ruth A

2007-07-01

The directivity of an adaptive directional microphone hearing aid (DMHA) cannot be assessed by the method that calls for presenting a "probe" signal from a single loudspeaker to the DMHA that moves to different angles. This method is invalid because the probe signal itself changes the polar pattern. This paper proposes a method for assessing the adaptive DMHA using a "jammer" signal, presented from a second loudspeaker rotating with the DMHA, that simulates a noise source and freezes the polar pattern. Measurement at each angle is obtained by two sequential recordings from the DMHA, one using an input of a probe and a jammer, and the other with an input of the same probe and a phase-inverted jammer. After canceling out the jammer, the remaining response to the probe signal can be used to assess the directivity. In this paper, the new method is evaluated by comparing responses from five adaptive DMHAs to different jammer intensities and locations. This method was shown to be an accurate and reliable way to assess the directivity of the adaptive DMHA in a high-intensity-jammer condition.

Objective and perceptual comparisons of two bluetooth hearing aid assistive devices.

PubMed

Clark, Jackie L; Pustejovsky, Carmen; Vanneste, Sven

2017-08-01

With the advent of Bluetooth technology, many of the assistive listening devices for hearing have become manufacturer specific, with little objective information about the performance provided. Thirty native English-speaking adults (mean age 29.8) with normal hearing were tested pseudo-randomly with two major hearing aid manufacturers' proprietary Bluetooth connectivity devices paired to the accompanying manufacturer's specific hearing aids. Sentence recognition performance was objectively measured for each system with signals transmitted via a land-line to the same iPhone in two conditions. There was a significant effect of participant's performance according to listening condition. There was no significant effect between device manufacturers according to listening condition, but there was a significant effect in participant's perception of "quality of sound". Despite differences in signal transmission for each devise, when worn by participants both the systems performed equally. In fact, participants expressed personal preferences for specific technology that was largely due to their perceived quality of sound while listening to recorded signals. While further research is necessary to investigate other measures of benefit for Bluetooth connectivity devices, preliminary data suggest that in order to ensure comfort and compatibility, not only should objective measures of the patient benefit be completed, but also assessing the patient's perception of benefit is equally important. Implications for Rehabilitation All professionals who work with individuals with hearing loss, become aware of the differences in the multiple choices for assistive technology readily available for hearing loss. With the ever growing dispensing of Bluetooth connectivity devices coupled to hearing aids, there is an increased burden to determine whether performance differences could exist between manufacturers. There is a growing need to investigate other measures of benefit for Bluetooth hearing aid connectivity devices that not only include objective measures, but also patient perception of benefit.

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

PubMed Central

Geisberger, Roland; Rada, Cristina; Neuberger, Michael S.

2009-01-01

The carboxyterminal region of activation-induced deaminase (AID) is required for its function in Ig class switch recombination (CSR) and also contains a nuclear-export sequence (NES). Here, based on an extensive fine-structure mutation analysis of the AID NES, as well as from AID chimeras bearing heterologous NESs, we show that while a functional NES is indeed essential for CSR, it is not sufficient. The precise nature of the NES is critical both for AID stabilization and CSR function: minor changes in the NES can perturb stabilization and CSR without jeopardizing nuclear export. The results indicate that the AID NES fulfills a function beyond simply providing a signal for nuclear export and suggest the possibility that the quality of exportin-binding may be critical to the stabilization of AID and its activity in CSR. PMID:19351893

Motor modules in robot-aided walking

PubMed Central

2012-01-01

Background It is hypothesized that locomotion is achieved by means of rhythm generating networks (central pattern generators) and muscle activation generating networks. This modular organization can be partly identified from the analysis of the muscular activity by means of factorization algorithms. The activity of rhythm generating networks is described by activation signals whilst the muscle intervention generating network is represented by motor modules (muscle synergies). In this study, we extend the analysis of modular organization of walking to the case of robot-aided locomotion, at varying speed and body weight support level. Methods Non Negative Matrix Factorization was applied on surface electromyographic signals of 8 lower limb muscles of healthy subjects walking in gait robotic trainer at different walking velocities (1 to 3km/h) and levels of body weight support (0 to 30%). Results The muscular activity of volunteers could be described by low dimensionality (4 modules), as for overground walking. Moreover, the activation signals during robot-aided walking were bursts of activation timed at specific phases of the gait cycle, underlying an impulsive controller, as also observed in overground walking. This modular organization was consistent across the investigated speeds, body weight support level, and subjects. Conclusions These results indicate that walking in a Lokomat robotic trainer is achieved by similar motor modules and activation signals as overground walking and thus supports the use of robotic training for re-establishing natural walking patterns. PMID:23043818

Kalman/Map filtering-aided fast normalized cross correlation-based Wi-Fi fingerprinting location sensing.

PubMed

Sun, Yongliang; Xu, Yubin; Li, Cheng; Ma, Lin

2013-11-13

A Kalman/map filtering (KMF)-aided fast normalized cross correlation (FNCC)-based Wi-Fi fingerprinting location sensing system is proposed in this paper. Compared with conventional neighbor selection algorithms that calculate localization results with received signal strength (RSS) mean samples, the proposed FNCC algorithm makes use of all the on-line RSS samples and reference point RSS variations to achieve higher fingerprinting accuracy. The FNCC computes efficiently while maintaining the same accuracy as the basic normalized cross correlation. Additionally, a KMF is also proposed to process fingerprinting localization results. It employs a new map matching algorithm to nonlinearize the linear location prediction process of Kalman filtering (KF) that takes advantage of spatial proximities of consecutive localization results. With a calibration model integrated into an indoor map, the map matching algorithm corrects unreasonable prediction locations of the KF according to the building interior structure. Thus, more accurate prediction locations are obtained. Using these locations, the KMF considerably improves fingerprinting algorithm performance. Experimental results demonstrate that the FNCC algorithm with reduced computational complexity outperforms other neighbor selection algorithms and the KMF effectively improves location sensing accuracy by using indoor map information and spatial proximities of consecutive localization results.

Kalman/Map Filtering-Aided Fast Normalized Cross Correlation-Based Wi-Fi Fingerprinting Location Sensing

PubMed Central

Sun, Yongliang; Xu, Yubin; Li, Cheng; Ma, Lin

2013-01-01

A Kalman/map filtering (KMF)-aided fast normalized cross correlation (FNCC)-based Wi-Fi fingerprinting location sensing system is proposed in this paper. Compared with conventional neighbor selection algorithms that calculate localization results with received signal strength (RSS) mean samples, the proposed FNCC algorithm makes use of all the on-line RSS samples and reference point RSS variations to achieve higher fingerprinting accuracy. The FNCC computes efficiently while maintaining the same accuracy as the basic normalized cross correlation. Additionally, a KMF is also proposed to process fingerprinting localization results. It employs a new map matching algorithm to nonlinearize the linear location prediction process of Kalman filtering (KF) that takes advantage of spatial proximities of consecutive localization results. With a calibration model integrated into an indoor map, the map matching algorithm corrects unreasonable prediction locations of the KF according to the building interior structure. Thus, more accurate prediction locations are obtained. Using these locations, the KMF considerably improves fingerprinting algorithm performance. Experimental results demonstrate that the FNCC algorithm with reduced computational complexity outperforms other neighbor selection algorithms and the KMF effectively improves location sensing accuracy by using indoor map information and spatial proximities of consecutive localization results. PMID:24233027

Pattern recognition in volcano seismology - Reducing spectral dimensionality

NASA Astrophysics Data System (ADS)

Unglert, K.; Radic, V.; Jellinek, M.

2015-12-01

Variations in the spectral content of volcano seismicity can relate to changes in volcanic activity. Low-frequency seismic signals often precede or accompany volcanic eruptions. However, they are commonly manually identified in spectra or spectrograms, and their definition in spectral space differs from one volcanic setting to the next. Increasingly long time series of monitoring data at volcano observatories require automated tools to facilitate rapid processing and aid with pattern identification related to impending eruptions. Furthermore, knowledge transfer between volcanic settings is difficult if the methods to identify and analyze the characteristics of seismic signals differ. To address these challenges we evaluate whether a machine learning technique called Self-Organizing Maps (SOMs) can be used to characterize the dominant spectral components of volcano seismicity without the need for any a priori knowledge of different signal classes. This could reduce the dimensions of the spectral space typically analyzed by orders of magnitude, and enable rapid processing and visualization. Preliminary results suggest that the temporal evolution of volcano seismicity at Kilauea Volcano, Hawai`i, can be reduced to as few as 2 spectral components by using a combination of SOMs and cluster analysis. We will further refine our methodology with several datasets from Hawai`i and Alaska, among others, and compare it to other techniques.

Alternative path to hearing: photonic sonogram hearing aid

NASA Astrophysics Data System (ADS)

Hara, Elmer H.

2002-05-01

For those with total hearing loss, there are no direct remedies except for electronic (i.e. cochlear) implants. They are invasive and do not always function in a satisfactory manner. Although sign language opens the window to a rich culture but communication with the hearing world is hindered. Lip reading can bridge that gap but communication is not without some stress. Inability to detect possible life threatening situations outside the visual field also affects the quality of life for those without the ability to hear. If the hearing process is viewed from the point of system engineering, there is a sound source and air is the transmission medium to the ear. The hearing structure of the ear converts mechanical vibrations to electrical signals that are then transmitted through nerve paths to the section of the brain where sound signals are processed. In most cases of total hearing loss, the hearing structure of the ear is non-functional. A cochlear implant bypasses this hearing structure. It electronically converts sounds from the air into their frequency components and feeds them into transmission nerve paths to the brain as electrical signals. This system-engineering point of view suggests that other pathways to the brain might be explored. The following section considers the visual pathway.

The monitoring of transient regimes on machine tools based on speed, acceleration and active electric power absorbed by motors

NASA Astrophysics Data System (ADS)

Horodinca, M.

2016-08-01

This paper intend to propose some new results related with computer aided monitoring of transient regimes on machine-tools based on the evolution of active electrical power absorbed by the electric motor used to drive the main kinematic chains and the evolution of rotational speed and acceleration of the main shaft. The active power is calculated in numerical format using the evolution of instantaneous voltage and current delivered by electrical power system to the electric motor. The rotational speed and acceleration of the main shaft are calculated based on the signal delivered by a sensor. Three real-time analogic signals are acquired with a very simple computer assisted setup which contains a voltage transformer, a current transformer, an AC generator as rotational speed sensor, a data acquisition system and a personal computer. The data processing and analysis was done using Matlab software. Some different transient regimes were investigated; several important conclusions related with the advantages of this monitoring technique were formulated. Many others features of the experimental setup are also available: to supervise the mechanical loading of machine-tools during cutting processes or for diagnosis of machine-tools condition by active electrical power signal analysis in frequency domain.

REVIEW ARTICLE: Spectrophotometric applications of digital signal processing

NASA Astrophysics Data System (ADS)

Morawski, Roman Z.

2006-09-01

Spectrophotometry is more and more often the method of choice not only in analysis of (bio)chemical substances, but also in the identification of physical properties of various objects and their classification. The applications of spectrophotometry include such diversified tasks as monitoring of optical telecommunications links, assessment of eating quality of food, forensic classification of papers, biometric identification of individuals, detection of insect infestation of seeds and classification of textiles. In all those applications, large numbers of data, generated by spectrophotometers, are processed by various digital means in order to extract measurement information. The main objective of this paper is to review the state-of-the-art methodology for digital signal processing (DSP) when applied to data provided by spectrophotometric transducers and spectrophotometers. First, a general methodology of DSP applications in spectrophotometry, based on DSP-oriented models of spectrophotometric data, is outlined. Then, the most important classes of DSP methods for processing spectrophotometric data—the methods for DSP-aided calibration of spectrophotometric instrumentation, the methods for the estimation of spectra on the basis of spectrophotometric data, the methods for the estimation of spectrum-related measurands on the basis of spectrophotometric data—are presented. Finally, the methods for preprocessing and postprocessing of spectrophotometric data are overviewed. Throughout the review, the applications of DSP are illustrated with numerous examples related to broadly understood spectrophotometry.

Self-Identifying Emergency Radio Beacons

NASA Technical Reports Server (NTRS)

Friedman, Morton L.

1987-01-01

Rescue teams aided by knowledge of vehicle in distress. Similar to conventional emergency transmitters except contains additional timing and modulating circuits. Additions to standard emergency transmitter enable transmitter to send rescuers identifying signal in addition to conventional distress signal created by sweep generator. Data generator contains identifying code.

An evaluation of computer-aided disproportionality analysis for post-marketing signal detection.

PubMed

Lehman, H P; Chen, J; Gould, A L; Kassekert, R; Beninger, P R; Carney, R; Goldberg, M; Goss, M A; Kidos, K; Sharrar, R G; Shields, K; Sweet, A; Wiholm, B E; Honig, P K

2007-08-01

To understand the value of computer-aided disproportionality analysis (DA) in relation to current pharmacovigilance signal detection methods, four products were retrospectively evaluated by applying an empirical Bayes method to Merck's post-marketing safety database. Findings were compared with the prior detection of labeled post-marketing adverse events. Disproportionality ratios (empirical Bayes geometric mean lower 95% bounds for the posterior distribution (EBGM05)) were generated for product-event pairs. Overall (1993-2004 data, EBGM05> or =2, individual terms) results of signal detection using DA compared to standard methods were sensitivity, 31.1%; specificity, 95.3%; and positive predictive value, 19.9%. Using groupings of synonymous labeled terms, sensitivity improved (40.9%). More of the adverse events detected by both methods were detected earlier using DA and grouped (versus individual) terms. With 1939-2004 data, diagnostic properties were similar to those from 1993 to 2004. DA methods using Merck's safety database demonstrate sufficient sensitivity and specificity to be considered for use as an adjunct to conventional signal detection methods.

Ambient seismic noise interferometry in Hawai'i reveals long-range observability of volcanic tremor

USGS Publications Warehouse

Ballmer, Silke; Wolfe, Cecily; Okubo, Paul G.; Haney, Matt; Thurber, Clifford H.

2013-01-01

The use of seismic noise interferometry to retrieve Green's functions and the analysis of volcanic tremor are both useful in studying volcano dynamics. Whereas seismic noise interferometry allows long-range extraction of interpretable signals from a relatively weak noise wavefield, the characterization of volcanic tremor often requires a dense seismic array close to the source. We here show that standard processing of seismic noise interferometry yields volcanic tremor signals observable over large distances exceeding 50 km. Our study comprises 2.5 yr of data from the U.S. Geological Survey Hawaiian Volcano Observatory short period seismic network. Examining more than 700 station pairs, we find anomalous and temporally coherent signals that obscure the Green's functions. The time windows and frequency bands of these anomalous signals correspond well with the characteristics of previously studied volcanic tremor sources at Pu'u 'Ō'ō and Halema'uma'u craters. We use the derived noise cross-correlation functions to perform a grid-search for source location, confirming that these signals are surface waves originating from the known tremor sources. A grid-search with only distant stations verifies that useful tremor signals can indeed be recovered far from the source. Our results suggest that the specific data processing in seismic noise interferometry—typically used for Green's function retrieval—can aid in the study of both the wavefield and source location of volcanic tremor over large distances. In view of using the derived Green's functions to image heterogeneity and study temporal velocity changes at volcanic regions, however, our results illustrate how care should be taken when contamination by tremor may be present.

Spatial separation benefit for unaided and aided listening

PubMed Central

Ahlstrom, Jayne B.; Horwitz, Amy R.; Dubno, Judy R.

2013-01-01

Consonant recognition in noise was measured at a fixed signal-to-noise ratio as a function of low-pass-cutoff frequency and noise location in older adults fit with bilateral hearing aids. To quantify age-related differences, spatial benefit was assessed in younger and older adults with normal hearing. Spatial benefit was similar for all groups suggesting that older adults used interaural difference cues to improve speech recognition in noise equivalently to younger adults. Although amplification was sufficient to increase high-frequency audibility with spatial separation, hearing-aid benefit was minimal, suggesting that factors beyond simple audibility may be responsible for limited hearing-aid benefit. PMID:24121648

Separating higher-order nonlinearities in transient absorption microscopy

NASA Astrophysics Data System (ADS)

Wilson, Jesse W.; Anderson, Miguel; Park, Jong Kang; Fischer, Martin C.; Warren, Warren S.

2015-08-01

The transient absorption response of melanin is a promising optically-accessible biomarker for distinguishing malignant melanoma from benign pigmented lesions, as demonstrated by earlier experiments on thin sections from biopsied tissue. The technique has also been demonstrated in vivo, but the higher optical intensity required for detecting these signals from backscattered light introduces higher-order nonlinearities in the transient response of melanin. These components that are higher than linear with respect to the pump or the probe introduce intensity-dependent changes to the overall response that complicate data analysis. However, our data also suggest these nonlinearities might be advantageous to in vivo imaging, in that different types of melanins have different nonlinear responses. Therefore, methods to separate linear from nonlinear components in transient absorption measurements might provide additional information to aid in the diagnosis of melanoma. We will discuss numerical methods for analyzing the various nonlinear contributions to pump-probe signals, with the ultimate objective of real time analysis using digital signal processing techniques. To that end, we have replaced the lock-in amplifier in our pump-probe microscope with a high-speed data acquisition board, and reprogrammed the coprocessor field-programmable gate array (FPGA) to perform lock-in detection. The FPGA lock-in offers better performance than the commercial instrument, in terms of both signal to noise ratio and speed. In addition, the flexibility of the digital signal processing approach enables demodulation of more complicated waveforms, such as spread-spectrum sequences, which has the potential to accelerate microscopy methods that rely on slow relaxation phenomena, such as photo-thermal and phosphorescence lifetime imaging.

In-situ sensing using mass spectrometry and its use for run-to-run control on a W-CVD cluster tool

NASA Astrophysics Data System (ADS)

Gougousi, T.; Sreenivasan, R.; Xu, Y.; Henn-Lecordier, L.; Rubloff, G. W.; Kidder, , J. N.; Zafiriou, E.

2001-01-01

A 300 amu closed-ion-source RGA (Leybold-Inficon Transpector 2) sampling gases directly from the reactor of an ULVAC ERA-1000 cluster tool has been used for real time process monitoring of a W CVD process. The process involves H2 reduction of WF6 at a total pressure of 67 Pa (0.5 torr) to produce W films on Si wafers heated at temperatures around 350 °C. The normalized RGA signals for the H2 reagent depletion and the HF product generation were correlated with the W film weight as measured post-process with an electronic microbalance for the establishment of thin-film weight (thickness) metrology. The metrology uncertainty (about 7% for the HF product) was limited primarily by the very low conversion efficiency of the W CVD process (around 2-3%). The HF metrology was then used to drive a robust run-to-run control algorithm, with the deposition time selected as the manipulated (or controlled) variable. For that purpose, during a 10 wafer run, a systematic process drift was introduced as a -5 °C processing temperature change for each successive wafer, in an otherwise unchanged process recipe. Without adjustment of the deposition time the W film weight (thickness) would have declined by about 50% by the 10th wafer. With the aid of the process control algorithm, an adjusted deposition time was computed so as to maintain constant HF sensing signal, resulting in weight (thickness) control comparable to the accuracy of the thickness metrology. These results suggest that in-situ chemical sensing, and particularly mass spectrometry, provide the basis for wafer state metrology as needed to achieve run-to-run control. Furthermore, since the control accuracy was consistent with the metrology accuracy, we anticipate significant improvements for processes as used in manufacturing, where conversion rates are much higher (40-50%) and corresponding signals for metrology will be much larger.

A situation-response model for intelligent pilot aiding

NASA Technical Reports Server (NTRS)

Schudy, Robert; Corker, Kevin

1987-01-01

An intelligent pilot aiding system needs models of the pilot information processing to provide the computational basis for successful cooperation between the pilot and the aiding system. By combining artificial intelligence concepts with the human information processing model of Rasmussen, an abstraction hierarchy of states of knowledge, processing functions, and shortcuts are developed, which is useful for characterizing the information processing both of the pilot and of the aiding system. This approach is used in the conceptual design of a real time intelligent aiding system for flight crews of transport aircraft. One promising result was the tentative identification of a particular class of information processing shortcuts, from situation characterizations to appropriate responses, as the most important reliable pathway for dealing with complex time critical situations.

Wearable Biomedical Measurement Systems for Assessment of Mental Stress of Combatants in Real Time

PubMed Central

Seoane, Fernando; Mohino-Herranz, Inmaculada; Ferreira, Javier; Alvarez, Lorena; Buendia, Ruben; Ayllón, David; Llerena, Cosme; Gil-Pita, Roberto

2014-01-01

The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants' operational capabilities. Within this framework the ATREC project funded by the “Coincidente” program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems. PMID:24759113

Carnivorous pitcher plant uses free radicals in the digestion of prey.

PubMed

Chia, Tet Fatt; Aung, Hnin Hnin; Osipov, Anatoly N; Goh, Ngoh Khang; Chia, Lian Sai

2004-01-01

A study of the involvement of free oxygen radicals in trapping and digestion of insects by carnivorous plants was the main goal of the present investigation. We showed that the generation of oxygen free radicals by pitcher fluid of Nepenthes is the first step of the digestion process, as seen by EPR spin trapping assay and gel-electrophoresis. The EPR spectrum of N. gracilis fluid in the presence of DMPO spin trap showed the superposition of the hydroxyl radical spin adduct signal and of the ascorbyl radical signal. Catalase addition decreased the generation of hydroxyl radicals showing that hydroxyl radicals are generated from hydrogen peroxide, which can be derived from superoxide radicals. Gel-electrophoresis data showed that myosin, an abundant protein component of insects, can be rapidly broken down by free radicals and protease inhibitors do not inhibit this process. Addition of myoglobin to the pitcher plant fluid decreased the concentration of detectable radicals. Based on these observations, we conclude that oxygen free radicals produced by the pitcher plant aid in the digestion of the insect prey.

Wearable biomedical measurement systems for assessment of mental stress of combatants in real time.

PubMed

Seoane, Fernando; Mohino-Herranz, Inmaculada; Ferreira, Javier; Alvarez, Lorena; Buendia, Ruben; Ayllón, David; Llerena, Cosme; Gil-Pita, Roberto

2014-04-22

The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants' operational capabilities. Within this framework the ATREC project funded by the "Coincidente" program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems.

Analog Computer-Aided Detection (CAD) information can be more effective than binary marks

PubMed Central

Cunningham, Corbin A.; Drew, Trafton; Wolfe, Jeremy M.

2017-01-01

In socially important visual search tasks such as baggage screening and diagnostic radiology, experts miss more targets than is desirable. Computer Aided Detection (CAD) programs have been developed specifically to help improve performance in these professional search tasks. For example, in breast cancer screening, many CAD systems are capable of detecting approximately 90% of breast cancer, with approximately 0.5 false positive detections per image. Nevertheless, benefits of CAD in clinical settings tend to be small (Birdwell, 2009) or even absent (Meziane et al., 2011; Philpotts, 2009). The marks made by a CAD system can be “Binary”, giving the same signal to any location where the signal is above some threshold. Alternatively, a CAD system present an Analog signal that reflected strength of the signal at a location. In the experiments reported here, we compare analog and binary CAD presentations using non-expert observers and artificial stimuli defined by two noisy signals: a visible color signal and an "invisible" signal that informed our simulated CAD system. We found that analog CAD generally yielded better overall performance than binary CAD. The analog benefit is similar at high and low target prevalence. Our data suggest that the form of the CAD signal can directly influence performance. Analog CAD may allow the computer to be more helpful to the searcher. PMID:27928658

Wavelet-based characterization of gait signal for neurological abnormalities.

PubMed

Baratin, E; Sugavaneswaran, L; Umapathy, K; Ioana, C; Krishnan, S

2015-02-01

Studies conducted by the World Health Organization (WHO) indicate that over one billion suffer from neurological disorders worldwide, and lack of efficient diagnosis procedures affects their therapeutic interventions. Characterizing certain pathologies of motor control for facilitating their diagnosis can be useful in quantitatively monitoring disease progression and efficient treatment planning. As a suitable directive, we introduce a wavelet-based scheme for effective characterization of gait associated with certain neurological disorders. In addition, since the data were recorded from a dynamic process, this work also investigates the need for gait signal re-sampling prior to identification of signal markers in the presence of pathologies. To benefit automated discrimination of gait data, certain characteristic features are extracted from the wavelet-transformed signals. The performance of the proposed approach was evaluated using a database consisting of 15 Parkinson's disease (PD), 20 Huntington's disease (HD), 13 Amyotrophic lateral sclerosis (ALS) and 16 healthy control subjects, and an average classification accuracy of 85% is achieved using an unbiased cross-validation strategy. The obtained results demonstrate the potential of the proposed methodology for computer-aided diagnosis and automatic characterization of certain neurological disorders. Copyright © 2015 Elsevier B.V. All rights reserved.

Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the Multicenter AIDS Cohort Study

PubMed Central

Wong, Hui-Lee; Breen, Elizabeth C.; Pfeiffer, Ruth M.; Aissani, Brahim; Martinson, Jeremy J.; Margolick, Joseph B.; Kaslow, Richard A.; Jacobson, Lisa P.; Ambinder, Richard F.; Chanock, Stephen; Martínez-Maza, Otoniel; Rabkin, Charles S.

2014-01-01

Cytokine stimulation of B-cell proliferation may be an important etiologic mechanism for acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). The Epstein-Barr virus may be a co-factor, particularly for primary central nervous system (CNS) tumors, which are uniformly EBV-positive in the setting of AIDS. Thus, we examined associations of genetic variation in IL10 and related cytokine signaling molecules (IL10RA, CXCL12, IL13, IL4, IL4R, CCL5 and BCL6) with AIDS-related NHL risk and evaluated differences between primary CNS and systemic tumors. We compared 160 Multicenter AIDS Cohort Study (MACS) participants with incident lymphomas, of which 90 followed another AIDS diagnosis, to HIV-1-seropositive controls matched on duration of lymphoma-free survival post-HIV-1 infection (N=160) or post-AIDS diagnosis (N=90). We fit conditional logistic regression models to estimate odds ratios (ORs) and 95 percent confidence intervals (95%CIs). Carriage of at least one copy of the T allele for the IL10 rs1800871 (as compared to no copies) was associated with decreased AIDS-NHL risk specific to lymphomas arising from the CNS (CC vs. CT/TT: OR=0.3; 95%CI: 0.1, 0.7) but not systemically (CC vs. CT/TT: OR=1.0; 95%CI: 0.5, 1.9) (Pheterogeneity=0.03). Carriage of two copies of the “low IL10” haplotype rs1800896_A/rs1800871_T/rs1800872_A was associated with decreased lymphoma risk that varied by number of copies (Ptrend=0.02). None of the ORs for the other studied polymorphisms was significantly different from 1.0. Excessive IL10 response to HIV-1 infection may be associated with increased risk of NHL, particularly in the CNS. IL10 dysregulation may be an important etiologic pathway for EBV-related lymphomagenesis. PMID:20299965

Counter Unmanned Aerial System Decision-Aid Logic Process (C-UAS DALP)

DTIC Science & Technology

decision -aid or logic process that bridges the middle elements of the kill... of use, location, general logic process , and reference mission. This is the framework for the IDEF0 functional architecture diagrams, decision -aid diagrams, logic process , and modeling and simulation....chain between detection to countermeasure response. This capstone project creates the logic for a decision process that transitions from the

Automated Student Aid Processing: The Challenge and Opportunity.

ERIC Educational Resources Information Center

St. John, Edward P.

1985-01-01

To utilize automated technology for student aid processing, it is necessary to work with multi-institutional offices (student aid, admissions, registration, and business) and to develop automated interfaces with external processing systems at state and federal agencies and perhaps at need-analysis organizations and lenders. (MLW)

Model–Free Visualization of Suspicious Lesions in Breast MRI Based on Supervised and Unsupervised Learning

PubMed Central

Twellmann, Thorsten; Meyer-Baese, Anke; Lange, Oliver; Foo, Simon; Nattkemper, Tim W.

2008-01-01

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important tool in breast cancer diagnosis, but evaluation of multitemporal 3D image data holds new challenges for human observers. To aid the image analysis process, we apply supervised and unsupervised pattern recognition techniques for computing enhanced visualizations of suspicious lesions in breast MRI data. These techniques represent an important component of future sophisticated computer-aided diagnosis (CAD) systems and support the visual exploration of spatial and temporal features of DCE-MRI data stemming from patients with confirmed lesion diagnosis. By taking into account the heterogeneity of cancerous tissue, these techniques reveal signals with malignant, benign and normal kinetics. They also provide a regional subclassification of pathological breast tissue, which is the basis for pseudo-color presentations of the image data. Intelligent medical systems are expected to have substantial implications in healthcare politics by contributing to the diagnosis of indeterminate breast lesions by non-invasive imaging. PMID:19255616

PHYTOCHOME STRUCTURE AND SIGNALING MECHANISMS

PubMed Central

Rockwell, Nathan C.; Su, Yi-Shin; Lagarias, J. Clark

2009-01-01

Phytochromes are a widespread family of red/far-red responsive photoreceptors first discovered in plants, where they constitute one of the three main classes of photomorphogenesis regulators. All phytochromes utilize covalently attached bilin chromophores that enable photoconversion between red-absorbing (Pr) and far-red-absorbing (Pfr) forms. Phytochromes are thus photoswitchable photosensors; canonical phytochromes have a conserved N-terminal photosensory core and a C-terminal regulatory region which typically includes a histidine-kinase-related domain. The discovery of new bacterial and cyanobacterial members of the phytochrome family within the last decade has greatly aided biochemical and structural characterization of this family, with the first crystal structure of a bacteriophytochrome photosensory core appearing in 2005. This structure and other recent biochemical studies have provided exciting new insights into the structure of phytochrome, the photoconversion process that is central to light sensing, and the mechanism of signal transfer by this important family of photoreceptors. PMID:16669784

Quantification of HCV RNA in Clinical Specimens by Branched DNA (bDNA) Technology.

PubMed

Wilber, J C; Urdea, M S

1999-01-01

The diagnosis and monitoring of hepatitis C virus (HCV) infection have been aided by the development of HCV RNA quantification assays A direct measure of viral load, HCV RNA quantification has the advantage of providing information on viral kinetics and provides unique insight into the disease process. Branched DNA (bDNA) signal amplification technology provides a novel approach for the direct quantification of HCV RNA in patient specimens. The bDNA assay measures HCV RNA at physiological levels by boosting the reporter signal, rather than by replicating target sequences as the means of detection, and thus avoids the errors inherent in the extraction and amplification of target sequences. Inherently quantitative and nonradioactive, the bDNA assay is amenable to routine use in a clinical research setting, and has been used by several groups to explore the natural history, pathogenesis, and treatment of HCV infection.

Assessment of Itakura Distance as a valuable feature for computer-aided classification of sleep stages.

PubMed

Ebrahimi, F; Mikaili, M; Estrada, E; Nazeran, H

2007-01-01

Staging and detection of various states of sleep derived from EEG and other biomedical signals have proven to be very helpful in diagnosis, prognosis and remedy of various sleep related disorders. The time consuming and costly process of visual scoring of sleep stages by a specialist has always motivated researchers to develop an automatic sleep scoring system and the first step toward achieving this task is finding discriminating characteristics (or features) for each stage. A vast variety of these features and methods have been investigated in the sleep literature with different degrees of success. In this study, we investigated the performance of a newly introduced measure: the Itakura Distance (ID), as a similarity measure between EEG and EOG signals. This work demonstrated and further confirmed the outcomes of our previous research that the Itakura Distance serves as a valuable similarity measure to differentiate between different sleep stages.

Noise reduction technologies implemented in head-worn preprocessors for improving cochlear implant performance in reverberant noise fields.

PubMed

Chung, King; Nelson, Lance; Teske, Melissa

2012-09-01

The purpose of this study was to investigate whether a multichannel adaptive directional microphone and a modulation-based noise reduction algorithm could enhance cochlear implant performance in reverberant noise fields. A hearing aid was modified to output electrical signals (ePreprocessor) and a cochlear implant speech processor was modified to receive electrical signals (eProcessor). The ePreprocessor was programmed to flat frequency response and linear amplification. Cochlear implant listeners wore the ePreprocessor-eProcessor system in three reverberant noise fields: 1) one noise source with variable locations; 2) three noise sources with variable locations; and 3) eight evenly spaced noise sources from 0° to 360°. Listeners' speech recognition scores were tested when the ePreprocessor was programmed to omnidirectional microphone (OMNI), omnidirectional microphone plus noise reduction algorithm (OMNI + NR), and adaptive directional microphone plus noise reduction algorithm (ADM + NR). They were also tested with their own cochlear implant speech processor (CI_OMNI) in the three noise fields. Additionally, listeners rated overall sound quality preferences on recordings made in the noise fields. Results indicated that ADM+NR produced the highest speech recognition scores and the most preferable rating in all noise fields. Factors requiring attention in the hearing aid-cochlear implant integration process are discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

Structural phylogenetic analysis of activation-induced deaminase function.

PubMed

Ichikawa, H Travis; Sowden, Mark P; Torelli, Andrew T; Bachl, Jürgen; Huang, Pinwei; Dance, Geoffrey S C; Marr, Shauna H; Robert, Jacques; Wedekind, Joseph E; Smith, Harold C; Bottaro, Andrea

2006-07-01

In mammals, activation-induced deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of Ig genes. SHM and CSR activities require separate regions within AID. A chromosome region maintenance 1 (CRM1)-dependent nuclear export signal (NES) at the AID C terminus is necessary for CSR, and has been suggested to associate with CSR-specific cofactors. CSR appeared late in AID evolution, during the emergence of land vertebrates from bony fish, which only display SHM. Here, we show that AID from African clawed frog (Xenopus laevis), but not pufferfish (Takifugu rubripes), can induce CSR in AID-deficient mouse B cells, although both are catalytically active in bacteria and mammalian cell systems, albeit at decreased level. Like mammalian AID, Takifugu AID is actively exported from the cell nucleus by CRM1, and the Takifugu NES can substitute for the equivalent region in human AID, indicating that all the CSR-essential NES motif functions evolutionarily predated CSR activity. We also show that fusion of the Takifugu AID catalytic domain to the entire human noncatalytic domain restores activity in mammalian cells, suggesting that AID features mapping within the noncatalytic domain, but outside the NES, influence its function.

Structural Health Monitoring and Impact Detection Using Neural Networks for Damage Characterization

NASA Technical Reports Server (NTRS)

Ross, Richard W.

2006-01-01

Detection of damage due to foreign object impact is an important factor in the development of new aerospace vehicles. Acoustic waves generated on impact can be detected using a set of piezoelectric transducers, and the location of impact can be determined by triangulation based on the differences in the arrival time of the waves at each of the sensors. These sensors generate electrical signals in response to mechanical motion resulting from the impact as well as from natural vibrations. Due to electrical noise and mechanical vibration, accurately determining these time differentials can be challenging, and even small measurement inaccuracies can lead to significant errors in the computed damage location. Wavelet transforms are used to analyze the signals at multiple levels of detail, allowing the signals resulting from the impact to be isolated from ambient electromechanical noise. Data extracted from these transformed signals are input to an artificial neural network to aid in identifying the moment of impact from the transformed signals. By distinguishing which of the signal components are resultant from the impact and which are characteristic of noise and normal aerodynamic loads, the time differentials as well as the location of damage can be accurately assessed. The combination of wavelet transformations and neural network processing results in an efficient and accurate approach for passive in-flight detection of foreign object damage.

The biology of skin wetness perception and its implications in manual function and for reproducing complex somatosensory signals in neuroprosthetics

PubMed Central

Ackerley, Rochelle

2017-01-01

Our perception of skin wetness is generated readily, yet humans have no known receptor (hygroreceptor) to signal this directly. It is easy to imagine the sensation of water running over our hands or the feel of rain on our skin. The synthetic sensation of wetness is thought to be produced from a combination of specific skin thermal and tactile inputs, registered through thermoreceptors and mechanoreceptors, respectively. The present review explores how thermal and tactile afference from the periphery can generate the percept of wetness centrally. We propose that the main signals include information about skin cooling, signaled primarily by thinly myelinated thermoreceptors, and rapid changes in touch, through fast-conducting, myelinated mechanoreceptors. Potential central sites for integration of these signals, and thus the perception of skin wetness, include the primary and secondary somatosensory cortices and the insula cortex. The interactions underlying these processes can also be modeled to aid in understanding and engineering the mechanisms. Furthermore, we discuss the role that sensing wetness could play in precision grip and the dexterous manipulation of objects. We expand on these lines of inquiry to the application of the knowledge in designing and creating skin sensory feedback in prosthetics. The addition of real-time, complex sensory signals would mark a significant advance in the use and incorporation of prosthetic body parts for amputees in everyday life. PMID:28123008

Should children who use cochlear implants wear hearing aids in the opposite ear?

PubMed

Ching, T Y; Psarros, C; Hill, M; Dillon, H; Incerti, P

2001-10-01

The aim of this study was to investigate 1) whether a hearing aid needs to be adjusted differently depending on whether a child wears a cochlear implant or another hearing aid in the contralateral ear; 2) whether the use of a hearing aid and a cochlear implant in opposite ears leads to binaural interference; and 3) whether the use of a hearing aid and a cochlear implant in opposite ears leads to binaural benefits in speech perception, localization, and communicative functioning in real life. Sixteen children participated in this study. All children used a Nucleus 22 or Nucleus 24 cochlear implant system programmed with the SPEAK strategy in one ear. The hearing aid amplification requirements in the nonimplanted ear of these children were determined using two procedures. A paired comparison technique was used to identify the frequency response that was best for speech intelligibility in quiet, and a loudness balancing technique was used to match the loudness of speech in the ear with a hearing aid to that with a cochlear implant. Eleven of the 16 children participated in the investigation of binaural effects. Performance in speech perception, localization, and communicative functioning was assessed under four aided conditions: cochlear implant with hearing aid as worn, cochlear implant alone, hearing aid alone, and cochlear implant with hearing aid adjusted according to individual requirements. Fifteen of the 16 children whose amplification requirements were determined preferred a hearing aid frequency response that was within +/-6 dB/octave of the NAL-RP prescription. On average, the children required 6 dB more gain than prescribed to balance the loudness of the implanted ear for a speech signal presented at 65 dB SPL. For all 11 children whose performance was evaluated for investigating binaural effects, there was no indication of significantly poorer performance under bilaterally aided conditions compared with unilaterally aided conditions. On average, there were significant benefits in speech perception, localization, and aural/oral function when the children used cochlear implants with adjusted hearing aids than when they used cochlear implants alone. All individuals showed benefits in at least one of the measures. Hearing aids for children who also use cochlear implants can be selected using the NAL-RP prescription. Adjustment of hearing aid gain to match loudness in the implanted ear can facilitate integration of signals from both ears, leading to better speech perception. Given that there are binaural advantages from using cochlear implants with hearing aids in opposite ears, clinicians should advise parents and other professionals about these potential advantages, and facilitate bilateral amplification by adjusting hearing aids after stable cochlear implant MAPs are established.

Are two ears not better than one?

PubMed

McArdle, Rachel A; Killion, Mead; Mennite, Monica A; Chisolm, Theresa H

2012-03-01

The decision to fit one or two hearing aids in individuals with binaural hearing loss has been debated for years. Although some 78% of U.S. hearing aid fittings are binaural (Kochkin , 2010), Walden and Walden (2005) presented data showing that 82% (23 of 28 patients) of their sample obtained significantly better speech recognition in noise scores when wearing one hearing aid as opposed to two. To conduct two new experiments to fuel the monaural/binaural debate. The first experiment was a replication of Walden and Walden (2005), whereas the second experiment examined the use of binaural cues to improve speech recognition in noise. A repeated measures experimental design. Twenty veterans (aged 59-85 yr), with mild to moderately severe binaurally symmetrical hearing loss who wore binaural hearing aids were recruited from the Audiology Department at the Bay Pines VA Healthcare System. Experiment 1 followed the procedures of the Walden and Walden study, where signal-to-noise ratio (SNR) loss was measured using the Quick Speech-in-Noise (QuickSIN) test on participants who were aided with their current hearing aids. Signal and noise were presented in the sound booth at 0° azimuth under five test conditions: (1) right ear aided, (2) left ear aided, (3) both ears aided, (4) right ear aided, left ear plugged, and (5) unaided. The opposite ear in (1) and (2) was left open. In Experiment 2, binaural Knowles Electronics Manikin for Acoustic Research (KEMAR) manikin recordings made in Lou Malnati's pizza restaurant during a busy period provided a typical real-world noise, while prerecorded target sentences were presented through a small loudspeaker located in front of the KEMAR manikin. Subjects listened to the resulting binaural recordings through insert earphones under the following four conditions: (1) binaural, (2) diotic, (3) monaural left, and (4) monaural right. Results of repeated measures ANOVAs demonstrated that the best speech recognition in noise performance was obtained by most participants with both ears aided in Experiment 1 and in the binaural condition in Experiment 2. In both experiments, only 20% of our subjects did better in noise with a single ear, roughly similar to the earlier Jerger et al (1993) finding that 8-10% of elderly hearing aid users preferred one hearing aid. American Academy of Audiology.

49 CFR 236.925 - Training specific to control office personnel.

Code of Federal Regulations, 2013 CFR

2013-10-01

... concerning the interface between the computer-aided dispatching system and the train control system, with... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Standards for Processor-Based Signal and Train Control Systems § 236.925 Training specific to control office...

49 CFR 236.925 - Training specific to control office personnel.

Code of Federal Regulations, 2011 CFR

2011-10-01

... concerning the interface between the computer-aided dispatching system and the train control system, with... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Standards for Processor-Based Signal and Train Control Systems § 236.925 Training specific to control office...

49 CFR 236.925 - Training specific to control office personnel.

Code of Federal Regulations, 2012 CFR

2012-10-01

... concerning the interface between the computer-aided dispatching system and the train control system, with... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Standards for Processor-Based Signal and Train Control Systems § 236.925 Training specific to control office...

49 CFR 236.925 - Training specific to control office personnel.

Code of Federal Regulations, 2010 CFR

2010-10-01

... concerning the interface between the computer-aided dispatching system and the train control system, with... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Standards for Processor-Based Signal and Train Control Systems § 236.925 Training specific to control office...

49 CFR 236.925 - Training specific to control office personnel.

Code of Federal Regulations, 2014 CFR

2014-10-01

... concerning the interface between the computer-aided dispatching system and the train control system, with... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Standards for Processor-Based Signal and Train Control Systems § 236.925 Training specific to control office...

Transponder-aided joint calibration and synchronization compensation for distributed radar systems.

PubMed

Wang, Wen-Qin

2015-01-01

High-precision radiometric calibration and synchronization compensation must be provided for distributed radar system due to separate transmitters and receivers. This paper proposes a transponder-aided joint radiometric calibration, motion compensation and synchronization for distributed radar remote sensing. As the transponder signal can be separated from the normal radar returns, it is used to calibrate the distributed radar for radiometry. Meanwhile, the distributed radar motion compensation and synchronization compensation algorithms are presented by utilizing the transponder signals. This method requires no hardware modifications to both the normal radar transmitter and receiver and no change to the operating pulse repetition frequency (PRF). The distributed radar radiometric calibration and synchronization compensation require only one transponder, but the motion compensation requires six transponders because there are six independent variables in the distributed radar geometry. Furthermore, a maximum likelihood method is used to estimate the transponder signal parameters. The proposed methods are verified by simulation results.

Non-Data Aided Doppler Shift Estimation for Underwater Acoustic Communication

DTIC Science & Technology

2014-05-01

in underwater acoustic wireless sensor networks . We analyzed the data collected from our experiments using non-data aided (blind) techniques such as...investigated different methods for blind Doppler shift estimation and compensation for a single carrier in underwater acoustic wireless sensor ...distributed underwater sensor networks . Detailed experimental and simulated results based on second order cyclostationary features of the received signals

Coherent versus noncoherent signaling for satellite-aided mobile communications

NASA Technical Reports Server (NTRS)

Davarian, F.; Sumida, J.

1986-01-01

The use of coherent versus noncoherent communications is an unresolved issue for the mobile satellite community. Should one select the more robust but less efficient noncoherent strategy for communications over satellite-aided mobile channels, or does the introduction of a space platform in the mobile link improve signal stability (both amplitude and phase) such that conventional coherent schemes become attractive? This publication tries to answer some of the questions by discussing the results from experiments using a coherent QPSK receiver. The issues discussed include items such as the measured performance in Rician fading, the link error floor in a fading environment, etc. The results are compared and contrasted with that of a noncoherent limiter/discriminator FM receiver.

Implementation of Context Aware e-Health Environments Based on Social Sensor Networks

PubMed Central

Aguirre, Erik; Led, Santiago; Lopez-Iturri, Peio; Azpilicueta, Leyre; Serrano, Luís; Falcone, Francisco

2016-01-01

In this work, context aware scenarios applied to e-Health and m-Health in the framework of typical households (urban and rural) by means of deploying Social Sensors will be described. Interaction with end-users and social/medical staff is achieved using a multi-signal input/output device, capable of sensing and transmitting environmental, biomedical or activity signals and information with the aid of a combined Bluetooth and Mobile system platform. The devices, which play the role of Social Sensors, are implemented and tested in order to guarantee adequate service levels in terms of multiple signal processing tasks as well as robustness in relation with the use wireless transceivers and channel variability. Initial tests within a Living Lab environment have been performed in order to validate overall system operation. The results obtained show good acceptance of the proposed system both by end users as well as by medical and social staff, increasing interaction, reducing overall response time and social inclusion levels, with a compact and moderate cost solution that can readily be largely deployed. PMID:26938539

A Sensitive Electrochemical Immunosensor Based on PAMAM Dendrimer-Encapsulated Au for Detection of Norfloxacin in Animal-Derived Foods.

PubMed

Liu, Bing; Li, Min; Zhao, Yaoshuai; Pan, Mingfei; Gu, Ying; Sheng, Wei; Fang, Guozhen; Wang, Shuo

2018-06-15

In this work, a sensitive electrochemical immunosensor has been reported for the determination of norfloxacin in animal-derived foods. The poly (amidoamine) dendrimer encapsulated gold nanoparticles (PAMAM-Au) played dual roles in the proposed sensing platform which not only accelerated the electron transfer process of sensing, but also increased the efficiency of the immobilized antibody. The HRP-labeled antigen, as the signal labels in the immunosensor, was introduced to catalyze the following reaction of the substrate hydroquinone with the aid of H₂O₂ in the competitive reaction. On the basis of the signal amplification of PAMAM-Au, the signal intensity was linearly related to the concentration of norfloxacin in the range of 1 μg·L −1 ⁻10 mg·L −1 . All the results showed that the proposed strategy with low LOD (0.3837 μg·L −1 ) and favorable recovery (91.6⁻106.1%) in the practical sample, and it could provide a suitable protocol for norfloxacin detection in animal-derived foods with high sensitivity, good accuracy, and stability.

Implementation of Context Aware e-Health Environments Based on Social Sensor Networks.

PubMed

Aguirre, Erik; Led, Santiago; Lopez-Iturri, Peio; Azpilicueta, Leyre; Serrano, Luís; Falcone, Francisco

2016-03-01

In this work, context aware scenarios applied to e-Health and m-Health in the framework of typical households (urban and rural) by means of deploying Social Sensors will be described. Interaction with end-users and social/medical staff is achieved using a multi-signal input/output device, capable of sensing and transmitting environmental, biomedical or activity signals and information with the aid of a combined Bluetooth and Mobile system platform. The devices, which play the role of Social Sensors, are implemented and tested in order to guarantee adequate service levels in terms of multiple signal processing tasks as well as robustness in relation with the use wireless transceivers and channel variability. Initial tests within a Living Lab environment have been performed in order to validate overall system operation. The results obtained show good acceptance of the proposed system both by end users as well as by medical and social staff, increasing interaction, reducing overall response time and social inclusion levels, with a compact and moderate cost solution that can readily be largely deployed.

Advances in Electrophysiological Research

PubMed Central

Kamarajan, Chella; Porjesz, Bernice

2015-01-01

Electrophysiological measures of brain function are effective tools to understand neurocognitive phenomena and sensitive indicators of pathophysiological processes associated with various clinical conditions, including alcoholism. Individuals with alcohol use disorder (AUD) and their high-risk offspring have consistently shown dysfunction in several electrophysiological measures in resting state (i.e., electroencephalogram) and during cognitive tasks (i.e., event-related potentials and event-related oscillations). Researchers have recently developed sophisticated signal-processing techniques to characterize different aspects of brain dynamics, which can aid in identifying the neural mechanisms underlying alcoholism and other related complex disorders. These quantitative measures of brain function also have been successfully used as endophenotypes to identify and help understand genes associated with AUD and related disorders. Translational research also is examining how brain electrophysiological measures potentially can be applied to diagnosis, prevention, and treatment. PMID:26259089

Advanced Beamformers for Cochlear Implant Users: Acute Measurement of Speech Perception in Challenging Listening Conditions

PubMed Central

Buechner, Andreas; Dyballa, Karl-Heinz; Hehrmann, Phillipp; Fredelake, Stefan; Lenarz, Thomas

2014-01-01

Objective To investigate the performance of monaural and binaural beamforming technology with an additional noise reduction algorithm, in cochlear implant recipients. Method This experimental study was conducted as a single subject repeated measures design within a large German cochlear implant centre. Twelve experienced users of an Advanced Bionics HiRes90K or CII implant with a Harmony speech processor were enrolled. The cochlear implant processor of each subject was connected to one of two bilaterally placed state-of-the-art hearing aids (Phonak Ambra) providing three alternative directional processing options: an omnidirectional setting, an adaptive monaural beamformer, and a binaural beamformer. A further noise reduction algorithm (ClearVoice) was applied to the signal on the cochlear implant processor itself. The speech signal was presented from 0° and speech shaped noise presented from loudspeakers placed at ±70°, ±135° and 180°. The Oldenburg sentence test was used to determine the signal-to-noise ratio at which subjects scored 50% correct. Results Both the adaptive and binaural beamformer were significantly better than the omnidirectional condition (5.3 dB±1.2 dB and 7.1 dB±1.6 dB (p<0.001) respectively). The best score was achieved with the binaural beamformer in combination with the ClearVoice noise reduction algorithm, with a significant improvement in SRT of 7.9 dB±2.4 dB (p<0.001) over the omnidirectional alone condition. Conclusions The study showed that the binaural beamformer implemented in the Phonak Ambra hearing aid could be used in conjunction with a Harmony speech processor to produce substantial average improvements in SRT of 7.1 dB. The monaural, adaptive beamformer provided an averaged SRT improvement of 5.3 dB. PMID:24755864

‘Low-hanging fruit’: Counting and accounting for children in PEPFAR-funded HIV/AIDS programmes in South Africa

PubMed Central

Reynolds, Lindsey J.

2014-01-01

The article traces the social life of a policy that aimed to define and circumscribe the ambiguous and contested category of the ‘orphaned and vulnerable children’ (OVC) in South Africa at the height of the ‘emergency response’ to HIV/AIDS. Drawing on several months of institutional ethnographic research conducted over the course of five years with South African organisations receiving funding from the US President’s Emergency Plan for AIDS Relief to provide services to ‘OVC’, the project interrogates the influence of governmental forms of counting and accounting on health policy and practice in South Africa. Focusing on the experiences of one organisation, the article describes a process of policy ‘translation’ typified by a series of disconnects between the intentions of a policy and the exigencies of implementation, structured by the ambiguous and flexible nature of the category of the ‘orphaned and vulnerable child’. In this context, the article argues, the uncertainty produced by the implementation of the guidelines was not simply an artifact of a poorly designed policy, but rather signals an underlying epistemological tension in the practice of ‘global health’, in which quantitative metrics designed for monitoring and evaluation are often incapable of approximating the complexities of everyday life. PMID:24498970

Ultrasensitive photoelectrochemical biosensor for the detection of HTLV-I DNA: A cascade signal amplification strategy integrating λ-exonuclease aided target recycling with hybridization chain reaction and enzyme catalysis.

PubMed

Shi, Xiao-Mei; Fan, Gao-Chao; Tang, Xueying; Shen, Qingming; Zhu, Jun-Jie

2018-06-30

Sensitive and specific detection of DNA is of great significance for clinical diagnosis. In this paper, an effective cascade signal amplification strategy was introduced into photoelectrochemical (PEC) biosensor for ultrasensitive detection of human T-cell lymphotropic virus type I (HTLV-I) DNA. This proposed signal amplification strategy integrates λ-exonuclease (λ-Exo) aided target recycling with hybridization chain reaction (HCR) and enzyme catalysis. In the presence of target DNA (tDNA) of HTLV-I, the designed hairpin DNA (h 1 DNA) hybridized with tDNA, subsequently recognized and cleaved by λ-Exo to set free tDNA. With the λ-Exo aided tDNA recycling, an increasing number of DNA fragments (output DNA, oDNA) were released from the digestion of h 1 DNA. Then, triggered by the hybridization of oDNA with capture DNA (cDNA), numerous biotin-labeled hairpin DNAs (h 2 DNA and h 3 DNA) could be loaded onto the photoelectrode via the HCR. Finally, avidin-labeled alkaline phosphatase (avidin-ALP) could be introduced onto the electrode by specific interaction between biotin and avidin. The ALP could catalyze dephosphorylation of phospho-L-ascorbic acid trisodium salt (AAP) to generate an efficient electron donor of ascorbic acid (AA), and thereby greatly increasing the photocurrent signal. By utilizing the proposed cascade signal amplification strategy, the fabricated PEC biosensor exhibited an ultrasensitive and specific detection of HTLV-I DNA down to 11.3 aM, and it also offered an effective strategy to detect other DNAs at ultralow levels. Copyright © 2018 Elsevier B.V. All rights reserved.

Adaptive noise reduction circuit for a sound reproduction system

NASA Technical Reports Server (NTRS)

Engebretson, A. Maynard (Inventor); O'Connell, Michael P. (Inventor)

1995-01-01

A noise reduction circuit for a hearing aid having an adaptive filter for producing a signal which estimates the noise components present in an input signal. The circuit includes a second filter for receiving the noise-estimating signal and modifying it as a function of a user's preference or as a function of an expected noise environment. The circuit also includes a gain control for adjusting the magnitude of the modified noise-estimating signal, thereby allowing for the adjustment of the magnitude of the circuit response. The circuit also includes a signal combiner for combining the input signal with the adjusted noise-estimating signal to produce a noise reduced output signal.

A novel magneto-DNA duplex probe for bacterial DNA detection based on exonuclease III-aided cycling amplification.

PubMed

Zeng, Yan; Wan, Yi; Zhang, Dun; Qi, Peng

2015-01-01

A novel magneto-DNA duplex probe for bacterial DNA detection based on exonuclease III (Exo-III) aided cycling amplification has been developed. This magneto-DNA duplex probe contains a partly hybrid fluorophore-modified capture probe and a fluorophore-modified signal probe with magnetic microparticle as carrier. In the presence of a perfectly matched target bacterial DNA, blunt 3'-terminus of the capture probe is formed, activating the Exo-III aided cycling amplification. Thus, Exo-III catalyzes the stepwise removal of mononucleotides from this terminus, releasing both fluorophore-modified signal probe, fluorescent dyes of the capture probe and target DNA. The released target DNA then starts a new cycle, while released fluorescent fragments are recovered with magnetic separation for fluorescence signal collection. This system exhibited sensitive detection of bacterial DNA, with a detection limit of 14 pM because of the unique cleavage function of Exo-III, high fluorescence intensity, and separating function of magneto-DNA duplex probes. Besides this sensitivity, this strategy exhibited excellent selectivity with mismatched bacterial DNA targets and other bacterial species targets and good applicability in real seawater samples, hence, this strategy could be potentially used for qualitative and quantitative analysis of bacteria. Copyright © 2014 Elsevier B.V. All rights reserved.

Aquifers as indicators of volcanic unrest - models of hydrological responses to magmatic activity and their geophysical signals

NASA Astrophysics Data System (ADS)

Strehlow, Karen; Gottsmann, Jo

2014-05-01

Aquifers respond to and modify the surface expressions of magmatic activity, and they can also become agents of unrest themselves. Therefore, monitoring the hydrology can provide a valuable window into subsurface processes in volcanic areas. Interpretations of unrest signals as groundwater responses to changes in the magmatic system can be found for many volcanoes. Changes in temperature and strain conditions, seismic excitation or the injection of magmatic fluids into hydrothermal systems are just a few of the proposed processes induced by magmatic activity that affect the local hydrology. Aquifer responses are described to include changes in water table levels, changes in temperature or composition of hydrothermal waters and pore pressure-induced ground deformation. We can observe these effects at the surface via geophysical and geochemical signals. To fully to utilise these indicators as monitoring and forecasting tools, however, it is necessary to improve our still poor understanding of the ongoing mechanisms in the interactions of hydrological and magmatic systems. An extensive literature research provided an overview on reported effects, which we investigate in detail using numerical modelling. The hydrogeophysical study uses finite element analysis to quantitatively test proposed mechanisms of aquifer excitation and the resultant geophysical signals. We present a set of generic models for two typical volcanic landforms - a stratovolcano and a caldera - that simulate the interaction between deeper magmatic systems with shallow-seated aquifers, focusing on strain and temperature effects. They predict pore pressure induced hydraulic head changes in the aquifer as well as changing groundwater temperatures and strain induced fluid migration. Volcano observatories can track these hydrological effects for example with potential field investigations or the monitoring of wells. The models allow us to explore the parameter space, contributing to a better understanding of the coupling of these two highly complex systems. Our results provide further insight into the subsurface processes at volcanic systems and will aid the evaluation of unrest signals with potential for improved eruption forecasting.

Visual feedback in stuttering therapy

NASA Astrophysics Data System (ADS)

Smolka, Elzbieta

1997-02-01

The aim of this paper is to present the results concerning the influence of visual echo and reverberation on the speech process of stutterers. Visual stimuli along with the influence of acoustic and visual-acoustic stimuli have been compared. Following this the methods of implementing visual feedback with the aid of electroluminescent diodes directed by speech signals have been presented. The concept of a computerized visual echo based on the acoustic recognition of Polish syllabic vowels has been also presented. All the research nd trials carried out at our center, aside from cognitive aims, generally aim at the development of new speech correctors to be utilized in stuttering therapy.

Laser production of articles from powders

DOEpatents

Lewis, Gary K.; Milewski, John O.; Cremers, David A.; Nemec, Ronald B.; Barbe, Michael R.

1998-01-01

Method and apparatus for forming articles from materials in particulate form in which the materials are melted by a laser beam and deposited at points along a tool path to form an article of the desired shape and dimensions. Preferably the tool path and other parameters of the deposition process are established using computer-aided design and manufacturing techniques. A controller comprised of a digital computer directs movement of a deposition zone along the tool path and provides control signals to adjust apparatus functions, such as the speed at which a deposition head which delivers the laser beam and powder to the deposition zone moves along the tool path.

Laser production of articles from powders

DOEpatents

Lewis, G.K.; Milewski, J.O.; Cremers, D.A.; Nemec, R.B.; Barbe, M.R.

1998-11-17

Method and apparatus for forming articles from materials in particulate form in which the materials are melted by a laser beam and deposited at points along a tool path to form an article of the desired shape and dimensions. Preferably the tool path and other parameters of the deposition process are established using computer-aided design and manufacturing techniques. A controller comprised of a digital computer directs movement of a deposition zone along the tool path and provides control signals to adjust apparatus functions, such as the speed at which a deposition head which delivers the laser beam and powder to the deposition zone moves along the tool path. 20 figs.

Calcium ions in aqueous solutions: Accurate force field description aided by ab initio molecular dynamics and neutron scattering

NASA Astrophysics Data System (ADS)

Martinek, Tomas; Duboué-Dijon, Elise; Timr, Štěpán; Mason, Philip E.; Baxová, Katarina; Fischer, Henry E.; Schmidt, Burkhard; Pluhařová, Eva; Jungwirth, Pavel

2018-06-01

We present a combination of force field and ab initio molecular dynamics simulations together with neutron scattering experiments with isotopic substitution that aim at characterizing ion hydration and pairing in aqueous calcium chloride and formate/acetate solutions. Benchmarking against neutron scattering data on concentrated solutions together with ion pairing free energy profiles from ab initio molecular dynamics allows us to develop an accurate calcium force field which accounts in a mean-field way for electronic polarization effects via charge rescaling. This refined calcium parameterization is directly usable for standard molecular dynamics simulations of processes involving this key biological signaling ion.

Treatment with a low pH processing aid to reduce campylobacter counts on broiler parts

USDA-ARS?s Scientific Manuscript database

New regulations and performance standards for Campylobacter have been implemented by the USDA - Food Safety and Inspection Service (FSIS). The objective of this study was to evaluate treatment with a low pH processing aid (CMS PoultrypHreshTM), a formulated low pH processing aid, to reduce numbers...

Correlation analysis of respiratory signals by using parallel coordinate plots.

PubMed

Saatci, Esra

2018-01-01

The understanding of the bonds and the relationships between the respiratory signals, i.e. the airflow, the mouth pressure, the relative temperature and the relative humidity during breathing may provide the improvement on the measurement methods of respiratory mechanics and sensor designs or the exploration of the several possible applications in the analysis of respiratory disorders. Therefore, the main objective of this study was to propose a new combination of methods in order to determine the relationship between respiratory signals as a multidimensional data. In order to reveal the coupling between the processes two very different methods were used: the well-known statistical correlation analysis (i.e. Pearson's correlation and cross-correlation coefficient) and parallel coordinate plots (PCPs). Curve bundling with the number intersections for the correlation analysis, Least Mean Square Time Delay Estimator (LMS-TDE) for the point delay detection and visual metrics for the recognition of the visual structures were proposed and utilized in PCP. The number of intersections was increased when the correlation coefficient changed from high positive to high negative correlation between the respiratory signals, especially if whole breath was processed. LMS-TDE coefficients plotted in PCP indicated well-matched point delay results to the findings in the correlation analysis. Visual inspection of PCB by visual metrics showed range, dispersions, entropy comparisons and linear and sinusoidal-like relationships between the respiratory signals. It is demonstrated that the basic correlation analysis together with the parallel coordinate plots perceptually motivates the visual metrics in the display and thus can be considered as an aid to the user analysis by providing meaningful views of the data. Copyright © 2017 Elsevier B.V. All rights reserved.

Telecoil-mode hearing aid compatibility performance requirements for wireless and cordless handsets: magnetic signal-to-noise.

PubMed

Julstrom, Stephen; Kozma-Spytek, Linda; Isabelle, Scott

2011-09-01

During the revision of the American National Standards Institute (ANSI) C63.19 and the development of the ANSI/Telecommunications Industry Association-1083 hearing aid compatibility standards, it became evident that additional data concerning user acceptance of interfering magnetic noises generated by wireless and cordless telephones were needed in order to determine the requirements for telecoil-coupling compatibility. Further insight was needed into the magnetic signal-to-noise (S/N) ratios required to achieve specific levels of telephone usability by hearing aid wearers. (A companion article addresses magnetic signal level requirements.) Test subjects used their own hearing aids. The magnetic signals were applied through large magnetic head-worn coils, selected for the field orientation appropriate for each hearing aid. After adjusting their aid's volume control to an acoustic speech reference, the subjects adjusted the applied magnetic signal level to find their Most Comfortable Level (MCL). Each subject then adjusted the levels of six of eight different representative interfering noises to three levels of subjective telephone usability: "usable for a brief call," "acceptable for normal use," and "excellent performance." Each subject's objective noise audibility threshold in the presence of speech was also obtained for the various noise types. The 57 test subjects covered an age range of 22 to 79 yr, with a self-reported hearing loss duration of 12 to 72 yr. All had telecoils that they used for at least some telecommunications needs. The self-reported degree of hearing loss ranged from moderate to profound. A guided intake questionnaire yielded general background information for each subject. A test control box fed by prepared speech and noise recordings from computer files enabled the subject or the tester, depending on the portion of the test, to select A-weighting-normalized noise interference levels in 1.25 dB steps relative to the selected MCL. For each subject for each tested noise type, the values for the selected S/N ratios were recorded for the three categories of subjective usability and the objective noise threshold. About half of the test subjects needed a minimum 21 dB S/N ratio for them to consider their listening experience "acceptable for normal use" of a telephone. With a 30 dB S/N ratio, about 85% of the subjects reported normal use acceptability. Significant differences were apparent in the measured S/N user requirements among the noise types, though, indicating a deficiency in an A-weighted level measurement's ability to consistently predict the subjective acceptability of the various noises. An improved weighting function having both spectral and temporal components was developed to substantially eliminate these predictive inconsistencies. The interfering noise level that subjects chose for a telephone usability rating of "excellent performance" matched closely their objectively measured noise audibility threshold. A rating of "acceptable for normal use" was typically achieved at a 4 dB higher noise level, and a rating of "usable for a brief call," at a 10.4 dB higher noise level. These results did not relate significantly to noise type or to the subject's aided noise-in-speech hearing acuity. American Academy of Audiology.

A wide bandwidth electrostatic field sensor for lightning research

NASA Technical Reports Server (NTRS)

Zaepfel, K. P.

1986-01-01

Data obtained from UHF Radar observation of direct-lightning strikes to the NASA F-106B airplane have indicated that most of the 690 strikes acquired during direct-strike lightning tests were triggered by the aircraft. As an aid in understanding the triggered lightning process, a wide bandwidth electric field measuring system was designed for the F-106B by implementing a clamped-detection signal processing concept originated at the Air Force Cambridge Research Lab in 1953. The detection scheme combines the signals from complementary stator pairs clamped to zero volts at the exact moment when each stator pair is maximally shielded by the rotor, a process that restores the dc level lost by the charge amplifier. The new system was implemented with four shutter-type field mills located at strategic points on the airplane. The bandwidth of the new system was determined in the laboratory to be from dc to over 100 Hz, whereas past designs had upper limits of 10 Hz to 100 Hz. To obtain the undisturbed electric field vector and total aircraft charge, the airborne field mill system is calibrated by using techniques involving results from ground and flight calibrations of the F-106B, laboratory tests of a metallized model, and a finite-difference time-domain electromagnetic computer code.

A wide bandwidth electrostatic field sensor for lightning research

NASA Technical Reports Server (NTRS)

Zaepfel, Klaus P.

1989-01-01

Data obtained from UHF radar observation of direct-lightning strikes to the NASA F-106B aircraft have indicated that most of the 690 strikes acquired during direct-strike lightning tests were triggered by the aircraft. As an aid in understanding the triggered lightning process, a wide bandwidth electric field measuring system was designed for the F-106B by implementing a clamped-detection signal processing concept originated at the Air Force Cambridge Research Lab in 1953. The detection scheme combines the signals from complementary stator pairs clamped to zero bolts at the exact moment when each stator pair is maximally shielded by the rotor, a process that restores the dc level lost by the charge amplifier. The system was implemented with four shutter-type field mills located at strategic points on the aircraft. The bandwidth of the system was determined in the laboratory to be from dc to over 100 Hz, whereas past designs had upper limits of 10 to 100 Hz. To obtain the undisturbed electric field vector and total aircraft charge, the airborne field mill system is calibrated by using techniques involving results from ground and flight calibrations of the F-106B, laboratory tests of a metallized model, and a finite difference time-domain electromagnetic computer code.

Performance as a Component of HIV/AIDS Education: Process and Collaboration for Empowerment and Discussion

PubMed Central

Jaganath, Devan

2011-01-01

The Process and Collaboration for Empowerment and Discussion (PACED) approach redefines the goals for employing the performing arts in HIV/AIDS education. Considering the complexity of the epidemic, art can appropriately address HIV/AIDS by placing a greater emphasis on the creative process, engaging people living with HIV/AIDS, and focusing on contextual barriers to prevention and care. This approach was implemented in Ghana in 2006 in the form of the Asetena Pa Concert Party project. An evaluation of the project after its completion showed that it promoted a sense of empowerment among people with HIV and community dialogue about the structural and cultural obstacles to HIV/AIDS prevention, supporting the use of PACED as a viable tool in comprehensive education regarding HIV/AIDS. PMID:21233444

A performance evaluation postprocessor for computer-aided design and analysis of communication systems

NASA Technical Reports Server (NTRS)

Tranter, W. H.

1979-01-01

A technique for estimating the signal-to-noise ratio at a point in a digital simulation of a communication system is described; the technique is essentially a digital realization of a technique proposed by Shepertycki (1964) for the evaluation of analog communication systems. Signals having lowpass or bandpass spectra may be used. Simulation results show the technique to be accurate over a wide range of signal-to-noise ratios.

Overexpression of the transcription factor NF-YC9 confers abscisic acid hypersensitivity in Arabidopsis.

PubMed

Bi, Chao; Ma, Yu; Wang, Xiao-Fang; Zhang, Da-Peng

2017-11-01

Nuclear factor Y (NF-Y) family proteins are involved in many developmental processes and responses to environmental cues in plants, but whether and how they regulate phytohormone abscisic acid (ABA) signaling need further studies. In the present study, we showed that over-expression of the NF-YC9 gene confers ABA hypersensitivity in both the early seedling growth and stomatal response, while down-regulation of NF-YC9 does not affect ABA response in these processes. We also showed that over-expression of the NF-YC9 gene confers salt and osmotic hypersensitivity in early seedling growth, which is likely to be directly associated with the ABA hypersensitivity. Further, we observed that NF-YC9 physically interacts with the ABA-responsive bZIP transcription factor ABA-INSENSITIVE5 (ABI5), and facilitates the function of ABI5 to bind and activate the promoter of a target gene EM6. Additionally, NF-YC9 up-regulates expression of the ABI5 gene in response to ABA. These findings show that NF-YC9 may be involved in ABA signaling as a positive regulator and likely functions redundantly together with other NF-YC members, and support the model that the NF-YC9 mediates ABA signaling via targeting to and aiding the ABA-responsive transcription factors such as ABI5.

Detection and classification of concealed weapons using a magnetometer-based portal

NASA Astrophysics Data System (ADS)

Kotter, Dale K.; Roybal, Lyle G.; Polk, Robert E.

2002-08-01

A concealed weapons detection technology was developed through the support of the National Institute of Justice (NIJ) to provide a non intrusive means for rapid detection, location, and archiving of data (including visual) of potential suspects and weapon threats. This technology, developed by the Idaho National Engineering and Environmental Laboratory (INEEL), has been applied in a portal style weapons detection system using passive magnetic sensors as its basis. This paper will report on enhancements to the weapon detection system to enable weapon classification and to discriminate threats from non-threats. Advanced signal processing algorithms were used to analyze the magnetic spectrum generated when a person passes through a portal. These algorithms analyzed multiple variables including variance in the magnetic signature from random weapon placement and/or orientation. They perform pattern recognition and calculate the probability that the collected magnetic signature correlates to a known database of weapon versus non-weapon responses. Neural networks were used to further discriminate weapon type and identify controlled electronic items such as cell phones and pagers. False alarms were further reduced by analyzing the magnetic detector response by using a Joint Time Frequency Analysis digital signal processing technique. The frequency components and power spectrum for a given sensor response were derived. This unique fingerprint provided additional information to aid in signal analysis. This technology has the potential to produce major improvements in weapon detection and classification.

Spectrally And Temporally Resolved Low-Light Level Video Microscopy

NASA Astrophysics Data System (ADS)

Wampler, John E.; Furukawa, Ruth; Fechheimer, Marcus

1989-12-01

The IDG law-light video microscope system was designed to aid studies of localization of subcellular luminescence sources and stimulus/response coupling in single living cells using luminescent probes. Much of the motivation for design of this instrument system came from the pioneering efforts of Dr. Reynolds (Reynolds, Q. Rev. Biophys. 5, 295-347; Reynolds and Taylor, Bioscience 30, 586-592) who showed the value of intensified video camera systems for detection and localizion of fluorescence and bioluminescence signals from biological tissues. Our instrument system has essentially two roles, 1) localization and quantitation of very weak bioluminescence signals and 2) quantitation of intracellular environmental characteristics such as pH and calcium ion concentrations using fluorescent and bioluminescent probes. The instrument system exhibits over one million fold operating range allowing visualization and enhancement of quantum limited images with quantum limited response, spectral analysis of fluorescence signals, and transmitted light imaging. The computer control of the system implements rapid switching between light regimes, spatially resolved spectral scanning, and digital data processing for spectral shape analysis and for detailed analysis of the statistical distribution of single cell measurements. The system design and software algorithms used by the system are summarized. These design criteria are illustrated with examples taken from studies of bioluminescence, applications of bioluminescence to study developmental processes and gene expression in single living cells, and applications of fluorescent probes to study stimulus/response coupling in living cells.

Ab initio study of the O4H(+) novel species: spectroscopic fingerprints to aid its observation.

PubMed

Xavier, F George D; Hernández-Lamoneda, Rámon

2015-06-28

A detailed ab initio characterization of the structural, energetic and spectroscopic properties of the novel O4H(+) species is presented. The equilibrium structures and relative energies of all multiplet states have been determined systematically by analyzing static and dynamical correlation effects. The two and three body dissociation processes have been studied and indicate the presence of conical intersections in various states including the ground state. Comparison with available thermochemical data is very good, supporting the applied methodology. The reaction, H3(+) + O4→ O4H(+) + H2, was found to be exothermic ΔH = -19.4 kcal mol(-1) and therefore, it is proposed that the product in the singlet state could be formed in the interstellar medium (ISM) via collision processes. To aid in its laboratory or radioastronomy detection in the interstellar medium we determined spectroscopic fingerprints. It is estimated for the most stable geometry of O4H(+) dipole allowed electronic transitions in the visible region at 429 nm and 666 nm, an intense band at 1745 cm(-1) in the infrared and signals at 40.6, 81.2 and 139.2 GHz in the microwave region at 10, 50 and 150 K respectively, relevant for detection in the ISM.

Applying Knowledge of Enzyme Biochemistry to the Prediction of Functional Sites for Aiding Drug Discovery.

PubMed

Pai, Priyadarshini P; Mondal, Sukanta

2017-01-01

Enzymes are biological catalysts that play an important role in determining the patterns of chemical transformations pertaining to life. Many milestones have been achieved in unraveling the mechanisms in which the enzymes orchestrate various cellular processes using experimental and computational approaches. Experimental studies generating nearly all possible mutations of target enzymes have been aided by rapid computational approaches aiming at enzyme functional classification, understanding domain organization, functional site identification. The functional architecture, essentially, is involved in binding or interaction with ligands including substrates, products, cofactors, inhibitors, providing for their function, such as in catalysis, ligand mediated cell signaling, allosteric regulation and post-translational modifications. With the increasing availability of enzyme information and advances in algorithm development, computational approaches have now become more capable of providing precise inputs for enzyme engineering, and in the process also making it more efficient. This has led to interesting findings, especially in aberrant enzyme interactions, such as hostpathogen interactions in infection, neurodegenerative diseases, cancer and diabetes. This review aims to summarize in retrospection - the mined knowledge, vivid perspectives and challenging strides in using available experimentally validated enzyme information for characterization. An analytical outlook is presented on the scope of exploring future directions. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Satellite-aided mobile radio concepts study: Concept definition of a satellite-aided mobile and personal radio communication system

NASA Technical Reports Server (NTRS)

Anderson, R. E.

1979-01-01

The satellite system requires the use of a large satellite antenna and spacecraft array power of about 12 kW or more depending on the operating frequency. Technology developments needed include large offset reflector multibeam antennas, satellite electrical power sybsystems providing greater than 12 kW of power, signal switching hardware, and linearized efficient solid state amplifiers for the satellite-aided mobile band. Presently there is no frequency assignment for this service, and it is recommended that an allocation be pursued. The satellite system appears to be within reasonable extrapolation of the state of the art. It is further recommended that the satellite-aided system spacecraft definition studies and supporting technology development be initiated.

Using Correlative Properties of Neighboring Pixels to Enhance Contrast-to-Noise Ratio of Abnormal Hippocampus in Patients With Intractable Epilepsy and Mesial Temporal Sclerosis.

PubMed

Parsons, Matthew S; Sharma, Aseem; Hildebolt, Charles

2018-06-12

To test whether an image-processing algorithm can aid in visualization of mesial temporal sclerosis on magnetic resonance imaging by selectively increasing contrast-to-noise ratio (CNR) between abnormal hippocampus and normal brain. In this Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study, baseline coronal fluid-attenuated inversion recovery images of 18 adults (10 females, eight males; mean age 41.2 years) with proven mesial temporal sclerosis were processed using a custom algorithm to produce corresponding enhanced images. Average (Hmean) and maximum (Hmax) CNR for abnormal hippocampus were calculated relative to normal ipsilateral white matter. CNR values for normal gray matter (GM) were similarly calculated using ipsilateral cingulate gyrus as the internal control. To evaluate effect of image processing on visual conspicuity of hippocampal signal alteration, a neuroradiologist masked to the side of hippocampal abnormality rated signal intensity (SI) of hippocampi on baseline and enhanced images using a five-point scale (definitely abnormal to definitely normal). Differences in Hmean, Hmax, GM, and SI ratings for abnormal hippocampi on baseline and enhanced images were assessed for statistical significance. Both Hmean and Hmax were significantly higher in enhanced images as compared to baseline images (p < 0.0001 for both). There was no significant difference in the GM between baseline and enhanced images (p = 0.9375). SI ratings showed a more confident identification of abnormality on enhanced images (p = 0.0001). Image-processing resulted in increased CNR of abnormal hippocampus without affecting the CNR of normal gray matter. This selective increase in conspicuity of abnormal hippocampus was associated with more confident identification of hippocampal signal alteration. Copyright © 2018 Academic Radiology. Published by Elsevier Inc. All rights reserved.

Approximated affine projection algorithm for feedback cancellation in hearing aids.

PubMed

Lee, Sangmin; Kim, In-Young; Park, Young-Cheol

2007-09-01

We propose an approximated affine projection (AP) algorithm for feedback cancellation in hearing aids. It is based on the conventional approach using the Gauss-Seidel (GS) iteration, but provides more stable convergence behaviour even with small step sizes. In the proposed algorithm, a residue of the weighted error vector, instead of the current error sample, is used to provide stable convergence. A new learning rate control scheme is also applied to the proposed algorithm to prevent signal cancellation and system instability. The new scheme determines step size in proportion to the prediction factor of the input, so that adaptation is inhibited whenever tone-like signals are present in the input. Simulation results verified the efficiency of the proposed algorithm.

EEOC sues aerospace company over firing of worker with AIDS. Equal Employment Opportunity Commission.

PubMed

1995-09-22

The Equal Employment Opportunity Commission (EEOC) filed suit against a New Jersey aerospace company for violating the Americans with Disabilities Act (ADA). AlliedSignal Aerospace is charged with refusing to provide reasonable accommodations to [name removed], an employee with AIDS, and terminating him when he announced that he was seeking legal counsel. AlliedSignal initially agreed to tailor the employee's schedule and exempt him from overnight business trips, then reneged on the agreement. Following disclosure of [name removed]'s diagnosis and intent to seek counsel, the company retaliated. [Name removed]'s evaluations plummeted and he was fired. [Name removed] is now deceased, but the EEOC continues to pursue charges on behalf of his estate.

Gain-Compensating Circuit For NDE and Ultrasonics

NASA Technical Reports Server (NTRS)

Kushnick, Peter W.

1987-01-01

High-frequency gain-compensating circuit designed for general use in nondestructive evaluation and ultrasonic measurements. Controls gain of ultrasonic receiver as function of time to aid in measuring attenuation of samples with high losses; for example, human skin and graphite/epoxy composites. Features high signal-to-noise ratio, large signal bandwidth and large dynamic range. Control bandwidth of 5 MHz ensures accuracy of control signal. Currently being used for retrieval of more information from ultrasonic signals sent through composite materials that have high losses, and to measure skin-burn depth in humans.

Stimulus Characteristics for Vestibular Stochastic Resonance to Improve Balance Function

NASA Technical Reports Server (NTRS)

Mulavara, Ajitkumar; Fiedler, Matthew; Kofman, Igor; Peters, Brian; Wood, Scott; Serrado, Jorge; Cohen, Helen; Reschke, Millard; Bloomberg, Jacob

2010-01-01

Stochastic resonance (SR) is a mechanism by which noise can enhance the response of neural systems to relevant sensory signals. Studies have shown that imperceptible stochastic vestibular electrical stimulation, when applied to normal young and elderly subjects, significantly improved their ocular stabilization reflexes in response to whole-body tilt as well as balance performance during postural disturbances. The goal of this study was to optimize the amplitude characteristics of the stochastic vestibular signals for balance performance during standing on an unstable surface. Subjects performed a standard balance task of standing on a block of foam with their eyes closed. Bipolar stochastic electrical stimulation was applied to the vestibular system using constant current stimulation through electrodes placed over the mastoid process behind the ears. Amplitude of the signals varied in the range of 0-700 microamperes. Balance performance was measured using a force plate under the foam block, and inertial motion sensors were placed on the torso and head. Balance performance with stimulation was significantly greater (10%-25%) than with no stimulation. The signal amplitude at which performance was maximized was in the range of 100-300 microamperes. Optimization of the amplitude of the stochastic signals for maximizing balance performance will have a significant impact on development of vestibular SR as a unique system to aid recovery of function in astronauts after long-duration space flight or in patients with balance disorders.

Investigation of Extended Bandwidth Hearing Aid Amplification on Speech Intelligibility and Sound Quality in Adults with Mild-to-Moderate Hearing Loss.

PubMed

Seeto, Angeline; Searchfield, Grant D

2018-03-01

Advances in digital signal processing have made it possible to provide a wide-band frequency response with smooth, precise spectral shaping. Several manufacturers have introduced hearing aids that are claimed to provide gain for frequencies up to 10-12 kHz. However, there is currently limited evidence and very few independent studies evaluating the performance of the extended bandwidth hearing aids that have recently become available. This study investigated an extended bandwidth hearing aid using measures of speech intelligibility and sound quality to find out whether there was a significant benefit of extended bandwidth amplification over standard amplification. Repeated measures study designed to examine the efficacy of extended bandwidth amplification compared to standard bandwidth amplification. Sixteen adult participants with mild-to-moderate sensorineural hearing loss. Participants were bilaterally fit with a pair of Widex Mind 440 behind-the-ear hearing aids programmed with a standard bandwidth fitting and an extended bandwidth fitting; the latter provided gain up to 10 kHz. For each fitting, and an unaided condition, participants completed two speech measures of aided benefit, the Quick Speech-in-Noise test (QuickSIN™) and the Phonak Phoneme Perception Test (PPT; high-frequency perception in quiet), and a measure of sound quality rating. There were no significant differences found between unaided and aided conditions for QuickSIN™ scores. For the PPT, there were statistically significantly lower (improved) detection thresholds at high frequencies (6 and 9 kHz) with the extended bandwidth fitting. Although not statistically significant, participants were able to distinguish between 6 and 9 kHz 50% better with extended bandwidth. No significant difference was found in ability to recognize phonemes in quiet between the unaided and aided conditions when phonemes only contained frequency content <6 kHz. However significant benefit was found with the extended bandwidth fitting for recognition of 9-kHz phonemes. No significant difference in sound quality preference was found between the standard bandwidth and extended bandwidth fittings. This study demonstrated that a pair of currently available extended bandwidth hearing aids was technically capable of delivering high-frequency amplification that was both audible and useable to listeners with mild-to-moderate hearing loss. This amplification was of acceptable sound quality. Further research, particularly field trials, is required to ascertain the real-world benefit of high-frequency amplification. American Academy of Audiology

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia

PubMed Central

Degryse, S; de Bock, C E; Demeyer, S; Govaerts, I; Bornschein, S; Verbeke, D; Jacobs, K; Binos, S; Skerrett-Byrne, D A; Murray, H C; Verrills, N M; Van Vlierberghe, P; Cools, J; Dun, M D

2018-01-01

Mutations in the interleukin-7 receptor (IL7R) or the Janus kinase 3 (JAK3) kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the development of T-ALL in mouse models. However, the signal transduction pathways downstream of JAK3 mutations remain poorly characterized. Here we describe the phosphoproteome downstream of the JAK3(L857Q)/(M511I) activating mutations in transformed Ba/F3 lymphocyte cells. Signaling pathways regulated by JAK3 mutants were assessed following acute inhibition of JAK1/JAK3 using the JAK kinase inhibitors ruxolitinib or tofacitinib. Comprehensive network interrogation using the phosphoproteomic signatures identified significant changes in pathways regulating cell cycle, translation initiation, mitogen-activated protein kinase and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT signaling, RNA metabolism, as well as epigenetic and apoptotic processes. Key regulatory proteins within pathways that showed altered phosphorylation following JAK inhibition were targeted using selumetinib and trametinib (MEK), buparlisib (PI3K) and ABT-199 (BCL2), and found to be synergistic in combination with JAK kinase inhibitors in primary T-ALL samples harboring JAK3 mutations. These data provide the first detailed molecular characterization of the downstream signaling pathways regulated by JAK3 mutations and provide further understanding into the oncogenic processes regulated by constitutive kinase activation aiding in the development of improved combinatorial treatment regimens. PMID:28852199

Discrete wavelet-aided delineation of PCG signal events via analysis of an area curve length-based decision statistic.

PubMed

Homaeinezhad, M R; Atyabi, S A; Daneshvar, E; Ghaffari, A; Tahmasebi, M

2010-12-01

The aim of this study is to describe a robust unified framework for segmentation of the phonocardiogram (PCG) signal sounds based on the false-alarm probability (FAP) bounded segmentation of a properly calculated detection measure. To this end, first the original PCG signal is appropriately pre-processed and then, a fixed sample size sliding window is moved on the pre-processed signal. In each slid, the area under the excerpted segment is multiplied by its curve-length to generate the Area Curve Length (ACL) metric to be used as the segmentation decision statistic (DS). Afterwards, histogram parameters of the nonlinearly enhanced DS metric are used for regulation of the α-level Neyman-Pearson classifier for FAP-bounded delineation of the PCG events. The proposed method was applied to all 85 records of Nursing Student Heart Sounds database (NSHSDB) including stenosis, insufficiency, regurgitation, gallop, septal defect, split sound, rumble, murmur, clicks, friction rub and snap disorders with different sampling frequencies. Also, the method was applied to the records obtained from an electronic stethoscope board designed for fulfillment of this study in the presence of high-level power-line noise and external disturbing sounds and as the results, no false positive (FP) or false negative (FN) errors were detected. High noise robustness, acceptable detection-segmentation accuracy of PCG events in various cardiac system conditions, and having no parameters dependency to the acquisition sampling frequency can be mentioned as the principal virtues and abilities of the proposed ACL-based PCG events detection-segmentation algorithm.

Signs, Symbols and Signals. Book Five. Project Drive.

ERIC Educational Resources Information Center

Zook, Doris; And Others

This Project Drive booklet titled Signs, Symbols, and Signals is one of eight booklets designed for intermediate-level English-as-a-second-language students and low-level adult basic education/basic reading students. The goal of the booklet is to aid the student in developing the oral and sight vocabulary necessary for a basic driver training…

33 CFR 67.10-5 - Location requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... signals § 67.10-5 Location requirements. The sound signal required by §§ 67.20-10, 67.25-10, and 67.30-10...

33 CFR 67.10-1 - Apparatus requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Apparatus requirements. 67.10-1 Section 67.10-1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... signals § 67.10-1 Apparatus requirements. The sound signal required by §§ 67.20-10, 67.25-10, and 67.30-10...

33 CFR 67.10-1 - Apparatus requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Apparatus requirements. 67.10-1 Section 67.10-1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... signals § 67.10-1 Apparatus requirements. The sound signal required by §§ 67.20-10, 67.25-10, and 67.30-10...

Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nomura, Masatoshi, E-mail: nomura@med.kyushu-u.ac.jp; Tanaka, Kimitaka; Wang, Lixiang

Highlights: Black-Right-Pointing-Pointer ActRIB signaling induces Snail and S100A4 expressions in prostate cancer cells. Black-Right-Pointing-Pointer The prostate cancer cell lines expressing an active form of ActRIB were established. Black-Right-Pointing-Pointer ActRIB signaling promotes EMT and lymph node metastasis in xenograft model. -- Abstract: Activin, a member of the transforming growth factor-{beta} family, has been known to be a growth and differentiating factor. Despite its pluripotent effects, the roles of activin signaling in prostate cancer pathogenesis are still unclear. In this study, we established several cell lines that express a constitutive active form of activin type IB receptor (ActRIBCA) in human prostate cancermore » cells, ALVA41 (ALVA-ActRIBCA). There was no apparent change in the proliferation of ALVA-ActRIBCA cells in vitro; however, their migratory ability was significantly enhanced. In a xenograft model, histological analysis revealed that the expression of Snail, a cell-adhesion-suppressing transcription factor, was dramatically increased in ALVA-ActRIBCA tumors, indicating epithelial mesenchymal transition (EMT). Finally, mice bearing ALVA-ActRIBCA cells developed multiple lymph node metastases. In this study, we demonstrated that ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT, and thereby aid in the aggressiveness and progression of prostate cancers.« less

A Binaural CI Research Platform for Oticon Medical SP/XP Implants Enabling ITD/ILD and Variable Rate Processing

PubMed Central

Adiloğlu, K.; Herzke, T.

2015-01-01

We present the first portable, binaural, real-time research platform compatible with Oticon Medical SP and XP generation cochlear implants. The platform consists of (a) a pair of behind-the-ear devices, each containing front and rear calibrated microphones, (b) a four-channel USB analog-to-digital converter, (c) real-time PC-based sound processing software called the Master Hearing Aid, and (d) USB-connected hardware and output coils capable of driving two implants simultaneously. The platform is capable of processing signals from the four microphones simultaneously and producing synchronized binaural cochlear implant outputs that drive two (bilaterally implanted) SP or XP implants. Both audio signal preprocessing algorithms (such as binaural beamforming) and novel binaural stimulation strategies (within the implant limitations) can be programmed by researchers. When the whole research platform is combined with Oticon Medical SP implants, interaural electrode timing can be controlled on individual electrodes to within ±1 µs and interaural electrode energy differences can be controlled to within ±2%. Hence, this new platform is particularly well suited to performing experiments related to interaural time differences in combination with interaural level differences in real-time. The platform also supports instantaneously variable stimulation rates and thereby enables investigations such as the effect of changing the stimulation rate on pitch perception. Because the processing can be changed on the fly, researchers can use this platform to study perceptual changes resulting from different processing strategies acutely. PMID:26721923

A Binaural CI Research Platform for Oticon Medical SP/XP Implants Enabling ITD/ILD and Variable Rate Processing.

PubMed

Backus, B; Adiloğlu, K; Herzke, T

2015-12-30

We present the first portable, binaural, real-time research platform compatible with Oticon Medical SP and XP generation cochlear implants. The platform consists of (a) a pair of behind-the-ear devices, each containing front and rear calibrated microphones, (b) a four-channel USB analog-to-digital converter, (c) real-time PC-based sound processing software called the Master Hearing Aid, and (d) USB-connected hardware and output coils capable of driving two implants simultaneously. The platform is capable of processing signals from the four microphones simultaneously and producing synchronized binaural cochlear implant outputs that drive two (bilaterally implanted) SP or XP implants. Both audio signal preprocessing algorithms (such as binaural beamforming) and novel binaural stimulation strategies (within the implant limitations) can be programmed by researchers. When the whole research platform is combined with Oticon Medical SP implants, interaural electrode timing can be controlled on individual electrodes to within ±1 µs and interaural electrode energy differences can be controlled to within ±2%. Hence, this new platform is particularly well suited to performing experiments related to interaural time differences in combination with interaural level differences in real-time. The platform also supports instantaneously variable stimulation rates and thereby enables investigations such as the effect of changing the stimulation rate on pitch perception. Because the processing can be changed on the fly, researchers can use this platform to study perceptual changes resulting from different processing strategies acutely. © The Author(s) 2015.

Topological properties of flat electroencephalography's state space

NASA Astrophysics Data System (ADS)

Ken, Tan Lit; Ahmad, Tahir bin; Mohd, Mohd Sham bin; Ngien, Su Kong; Suwa, Tohru; Meng, Ong Sie

2016-02-01

Neuroinverse problem are often associated with complex neuronal activity. It involves locating problematic cell which is highly challenging. While epileptic foci localization is possible with the aid of EEG signals, it relies greatly on the ability to extract hidden information or pattern within EEG signals. Flat EEG being an enhancement of EEG is a way of viewing electroencephalograph on the real plane. In the perspective of dynamical systems, Flat EEG is equivalent to epileptic seizure hence, making it a great platform to study epileptic seizure. Throughout the years, various mathematical tools have been applied on Flat EEG to extract hidden information that is hardly noticeable by traditional visual inspection. While these tools have given worthy results, the journey towards understanding seizure process completely is yet to be succeeded. Since the underlying structure of Flat EEG is dynamic and is deemed to contain wealthy information regarding brainstorm, it would certainly be appealing to explore in depth its structures. To better understand the complex seizure process, this paper studies the event of epileptic seizure via Flat EEG in a more general framework by means of topology, particularly, on the state space where the event of Flat EEG lies.

Medical diagnosis imaging systems: image and signal processing applications aided by fuzzy logic

NASA Astrophysics Data System (ADS)

Hata, Yutaka

2010-04-01

First, we describe an automated procedure for segmenting an MR image of a human brain based on fuzzy logic for diagnosing Alzheimer's disease. The intensity thresholds for segmenting the whole brain of a subject are automatically determined by finding the peaks of the intensity histogram. After these thresholds are evaluated in a region growing, the whole brain can be identified. Next, we describe a procedure for decomposing the obtained whole brain into the left and right cerebral hemispheres, the cerebellum and the brain stem. Our method then identified the whole brain, the left cerebral hemisphere, the right cerebral hemisphere, the cerebellum and the brain stem. Secondly, we describe a transskull sonography system that can visualize the shape of the skull and brain surface from any point to examine skull fracture and some brain diseases. We employ fuzzy signal processing to determine the skull and brain surface. The phantom model, the animal model with soft tissue, the animal model with brain tissue, and a human subjects' forehead is applied in our system. The all shapes of the skin surface, skull surface, skull bottom, and brain tissue surface are successfully determined.

Hyperbaric Oxygen, Vasculogenic Stem Cells, and Wound Healing

PubMed Central

Fosen, Katina M.

2014-01-01

Abstract Significance: Oxidative stress is recognized as playing a role in stem cell mobilization from peripheral sites and also cell function. Recent Advances: This review focuses on the impact of hyperoxia on vasculogenic stem cells and elements of wound healing. Critical Issues: Components of the wound-healing process in which oxidative stress has a positive impact on the various cells involved in wound healing are highlighted. A slightly different view of wound-healing physiology is adopted by departing from the often used notion of sequential stages: hemostatic, inflammatory, proliferative, and remodeling and instead organizes the cascade of wound healing as overlapping events or waves pertaining to reactive oxygen species, lactate, and nitric oxide. This was done because hyperoxia has effects of a number of cell signaling events that converge to influence cell recruitment/chemotaxis and gene regulation/protein synthesis responses which mediate wound healing. Future Directions: Our alternative perspective of the stages of wound healing eases recognition of the multiple sites where oxidative stress has an impact on wound healing. This aids the focus on mechanistic events and the interplay among various cell types and biochemical processes. It also highlights the areas where additional research is needed. Antioxid. Redox Signal. 21, 1634–1647. PMID:24730726

Transcription factor YY1 can control AID-mediated mutagenesis in mice.

PubMed

Zaprazna, Kristina; Basu, Arindam; Tom, Nikola; Jha, Vibha; Hodawadekar, Suchita; Radova, Lenka; Malcikova, Jitka; Tichy, Boris; Pospisilova, Sarka; Atchison, Michael L

2018-02-01

Activation-induced cytidine deminase (AID) is crucial for controlling the immunoglobulin (Ig) diversification processes of somatic hypermutation (SHM) and class switch recombination (CSR). AID initiates these processes by deamination of cytosine, ultimately resulting in mutations or double strand DNA breaks needed for SHM and CSR. Levels of AID control mutation rates, and off-target non-Ig gene mutations can contribute to lymphomagenesis. Therefore, factors that control AID levels in the nucleus can regulate SHM and CSR, and may contribute to disease. We previously showed that transcription factor YY1 can regulate the level of AID in the nucleus and Ig CSR. Therefore, we hypothesized that conditional knock-out of YY1 would lead to reduction in AID localization at the Ig locus, and reduced AID-mediated mutations. Using mice that overexpress AID (IgκAID yy1 f/f ) or that express normal AID levels (yy1 f/f ), we found that conditional knock-out of YY1 results in reduced AID nuclear levels, reduced localization of AID to the Sμ switch region, and reduced AID-mediated mutations. We find that the mechanism of YY1 control of AID nuclear accumulation is likely due to YY1-AID physical interaction which blocks AID ubiquitination. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Cancer models in C. elegans

PubMed Central

Kirienko, Natalia V.; Mani, Kumaran; Fay, David S.

2013-01-01

Although now dogma, the idea that non-vertebrate organisms such as yeast, worms, and flies could inform, and in some cases even revolutionize, our understanding of oncogenesis in humans was not immediately obvious. Aided by the conservative nature of evolution and the persistence of a cohort of devoted researchers, the role of model organisms as a key tool in solving the cancer problem has, however, become widely accepted. In this review, we focus on the nematode Caenorhabditis elegans and its diverse and sometimes surprising contributions to our understanding of the tumorigenic process. Specifically, we discuss findings in the worm that address a well-defined set of processes known to be deregulated in cancer cells including cell cycle progression, growth factor signaling, terminal differentiation, apoptosis, the maintenance of genome stability, and developmental mechanisms relevant to invasion and metastasis. PMID:20175192

Efficient method for events detection in phonocardiographic signals

NASA Astrophysics Data System (ADS)

Martinez-Alajarin, Juan; Ruiz-Merino, Ramon

2005-06-01

The auscultation of the heart is still the first basic analysis tool used to evaluate the functional state of the heart, as well as the first indicator used to submit the patient to a cardiologist. In order to improve the diagnosis capabilities of auscultation, signal processing algorithms are currently being developed to assist the physician at primary care centers for adult and pediatric population. A basic task for the diagnosis from the phonocardiogram is to detect the events (main and additional sounds, murmurs and clicks) present in the cardiac cycle. This is usually made by applying a threshold and detecting the events that are bigger than the threshold. However, this method usually does not allow the detection of the main sounds when additional sounds and murmurs exist, or it may join several events into a unique one. In this paper we present a reliable method to detect the events present in the phonocardiogram, even in the presence of heart murmurs or additional sounds. The method detects relative maxima peaks in the amplitude envelope of the phonocardiogram, and computes a set of parameters associated with each event. Finally, a set of characteristics is extracted from each event to aid in the identification of the events. Besides, the morphology of the murmurs is also detected, which aids in the differentiation of different diseases that can occur in the same temporal localization. The algorithms have been applied to real normal heart sounds and murmurs, achieving satisfactory results.

Combining principles of Cognitive Load Theory and diagnostic error analysis for designing job aids: Effects on motivation and diagnostic performance in a process control task.

PubMed

Kluge, Annette; Grauel, Britta; Burkolter, Dina

2013-03-01

Two studies are presented in which the design of a procedural aid and the impact of an additional decision aid for process control were assessed. In Study 1, a procedural aid was developed that avoids imposing unnecessary extraneous cognitive load on novices when controlling a complex technical system. This newly designed procedural aid positively affected germane load, attention, satisfaction, motivation, knowledge acquisition and diagnostic speed for novel faults. In Study 2, the effect of a decision aid for use before the procedural aid was investigated, which was developed based on an analysis of diagnostic errors committed in Study 1. Results showed that novices were able to diagnose both novel faults and practised faults, and were even faster at diagnosing novel faults. This research contributes to the question of how to optimally support novices in dealing with technical faults in process control. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Three-channel false colour AFM images for improved interpretation of complex surfaces: a study of filamentous cyanobacteria.

PubMed

Kurk, Toby; Adams, David G; Connell, Simon D; Thomson, Neil H

2010-05-01

Imaging signals derived from the atomic force microscope (AFM) are typically presented as separate adjacent images with greyscale or pseudo-colour palettes. We propose that information-rich false-colour composites are a useful means of presenting three-channel AFM image data. This method can aid the interpretation of complex surfaces and facilitate the perception of information that is convoluted across data channels. We illustrate this approach with images of filamentous cyanobacteria imaged in air and under aqueous buffer, using both deflection-modulation (contact) mode and amplitude-modulation (tapping) mode. Topography-dependent contrast in the error and tertiary signals aids the interpretation of the topography signal by contributing additional data, resulting in a more detailed image, and by showing variations in the probe-surface interaction. Moreover, topography-independent contrast and topography-dependent contrast in the tertiary data image (phase or friction) can be distinguished more easily as a consequence of the three dimensional colour-space.

EEG-Based Computer Aided Diagnosis of Autism Spectrum Disorder Using Wavelet, Entropy, and ANN

PubMed Central

AlSharabi, Khalil; Ibrahim, Sutrisno; Alsuwailem, Abdullah

2017-01-01

Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder with core impairments in the social relationships, communication, imagination, or flexibility of thought and restricted repertoire of activity and interest. In this work, a new computer aided diagnosis (CAD) of autism ‎based on electroencephalography (EEG) signal analysis is investigated. The proposed method is based on discrete wavelet transform (DWT), entropy (En), and artificial neural network (ANN). DWT is used to decompose EEG signals into approximation and details coefficients to obtain EEG subbands. The feature vector is constructed by computing Shannon entropy values from each EEG subband. ANN classifies the corresponding EEG signal into normal or autistic based on the extracted features. The experimental results show the effectiveness of the proposed method for assisting autism diagnosis. A receiver operating characteristic (ROC) curve metric is used to quantify the performance of the proposed method. The proposed method obtained promising results tested using real dataset provided by King Abdulaziz Hospital, Jeddah, Saudi Arabia. PMID:28484720

Horizontal localization and speech intelligibility with bilateral and unilateral hearing aid amplification.

PubMed

Köbler, S; Rosenhall, U

2002-10-01

Speech intelligibility and horizontal localization of 19 subjects with mild-to-moderate hearing loss were studied in order to evaluate the advantages and disadvantages of bilateral and unilateral hearing aid (HA) fittings. Eight loudspeakers were arranged in a circular array covering the horizontal plane around the subjects. Speech signals of a sentence test were delivered by one, randomly chosen, loudspeaker. At the same time, the other seven loudspeakers emitted noise with the same long-term average spectrum as the speech signals. The subjects were asked to repeat the speech signal and to point out the corresponding loudspeaker. Speech intelligibility was significantly improved by HAs, bilateral amplification being superior to unilateral. Horizontal localization could not be improved by HA amplification. However, bilateral HAs preserved the subjects' horizontal localization, whereas unilateral amplification decreased their horizontal localization abilities. Front-back confusions were common in the horizontal localization test. The results indicate that bilateral HA amplification has advantages compared with unilateral amplification.

Preparation of Grinding Aid Using Waste Acid Residue from Plasticizer Plant

NASA Astrophysics Data System (ADS)

Li, Lingxiao; Feng, Yanchao; Liu, Manchao; Zhao, Fengqing

2017-09-01

The grinding aid for granulated blast-furnace slag were prepared from waste acid residue from plasticizer plant through neutralization, de-methanol and granulation process. In this process, sulfuric acid was transformed into gypsum which has much contribution for grinding effect by combined use with the glycerol and poly glycerin in the waste. Fly ash was used for granulation for the composite grinding aid. Methanol can be recycled in the process. The result showed that the suitable addition of grinding aid is 0.03 % of granulated blast-furnace slag (mass). In this case, the specific surface area is 14% higher than that of the blank. Compared with the common grinding aids, it has excellent performance and low cost.

Process evaluation to explore internal and external validity of the "Act in Case of Depression" care program in nursing homes.

PubMed

Leontjevas, Ruslan; Gerritsen, Debby L; Koopmans, Raymond T C M; Smalbrugge, Martin; Vernooij-Dassen, Myrra J F J

2012-06-01

A multidisciplinary, evidence-based care program to improve the management of depression in nursing home residents was implemented and tested using a stepped-wedge design in 23 nursing homes (NHs): "Act in case of Depression" (AiD). Before effect analyses, to evaluate AiD process data on sampling quality (recruitment and randomization, reach) and intervention quality (relevance and feasibility, extent to which AiD was performed), which can be used for understanding internal and external validity. In this article, a model is presented that divides process evaluation data into first- and second-order process data. Qualitative and quantitative data based on personal files of residents, interviews of nursing home professionals, and a research database were analyzed according to the following process evaluation components: sampling quality and intervention quality. Nursing home. The pattern of residents' informed consent rates differed for dementia special care units and somatic units during the study. The nursing home staff was satisfied with the AiD program and reported that the program was feasible and relevant. With the exception of the first screening step (nursing staff members using a short observer-based depression scale), AiD components were not performed fully by NH staff as prescribed in the AiD protocol. Although NH staff found the program relevant and feasible and was satisfied with the program content, individual AiD components may have different feasibility. The results on sampling quality implied that statistical analyses of AiD effectiveness should account for the type of unit, whereas the findings on intervention quality implied that, next to the type of unit, analyses should account for the extent to which individual AiD program components were performed. In general, our first-order process data evaluation confirmed internal and external validity of the AiD trial, and this evaluation enabled further statistical fine tuning. The importance of evaluating the first-order process data before executing statistical effect analyses is thus underlined. Copyright © 2012 American Medical Directors Association, Inc. Published by Elsevier Inc. All rights reserved.

Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6

PubMed Central

Ruff, Kristin R; Puetter, Adriane; Levy, Laura S

2007-01-01

Background AIDS-related non-Hodgkin's lymphoma (AIDS-NHL) is the second most frequent cancer associated with AIDS, and is a frequent cause of death in HIV-infected individuals. Experimental analysis of AIDS-NHL has been facilitated by the availability of an excellent animal model, i.e., simian Acquired Immunodeficiency Syndrome (SAIDS) in the rhesus macaque consequent to infection with simian immunodeficiency virus. A recent study of SAIDS-NHL demonstrated a lymphoma-derived cell line to be sensitive to the growth inhibitory effects of the ubiquitous cytokine, transforming growth factor-beta (TGF-beta). The authors concluded that TGF-beta acts as a negative growth regulator of the lymphoma-derived cell line and, potentially, as an inhibitory factor in the regulatory network of AIDS-related lymphomagenesis. The present study was conducted to assess whether other SAIDS-NHL and AIDS-NHL cell lines are similarly sensitive to the growth inhibitory effects of TGF-beta, and to test the hypothesis that interleukin-6 (IL-6) may represent a counteracting positive influence in their growth regulation. Methods Growth stimulation or inhibition in response to cytokine treatment was quantified using trypan blue exclusion or colorimetric MTT assay. Intracellular flow cytometry was used to analyze the activation of signaling pathways and to examine the expression of anti-apoptotic proteins and distinguishing hallmarks of AIDS-NHL subclass. Apoptosis was quantified by flow cytometric analysis of cell populations with sub-G1 DNA content and by measuring activated caspase-3. Results Results confirmed the sensitivity of LCL8664, an immunoblastic SAIDS-NHL cell line, to TGF-beta1-mediated growth inhibition, and further demonstrated the partial rescue by simultaneous treatment with IL-6. IL-6 was shown to activate STAT3, even in the presence of TGF-beta1, and thereby to activate proliferative and anti-apoptotic pathways. By comparison, human AIDS-NHL cell lines differed in their responsiveness to TGF-beta1 and IL-6. Analysis of a recently derived AIDS-NHL cell line, UMCL01-101, indicated that it represents immunoblastic AIDS-DLCBL. Like LCL-8664, UMCL01-101 was sensitive to TGF-beta1-mediated inhibition, rescued partially by IL-6, and demonstrated rapid STAT3 activation following IL-6 treatment even in the presence of TGF-beta1. Conclusion These studies indicate that the sensitivity of immunoblastic AIDS- or SAIDS-DLBCL to TGF-beta1-mediated growth inhibition may be overcome through the stimulation of proliferative and anti-apoptotic signals by IL-6, particularly through the rapid activation of STAT3. PMID:17324269

Aligning faith-based and national HIV/AIDS prevention responses? Factors influencing the HIV/AIDS prevention policy process and response of faith-based NGOs in Tanzania.

PubMed

Morgan, Rosemary; Green, Andrew; Boesten, Jelke

2014-05-01

Faith-based organizations (FBOs) have a long tradition of providing HIV/AIDS prevention and mitigation services in Africa. The overall response of FBOs, however, has been controversial, particularly in regard to HIV/AIDS prevention and FBO's rejection of condom use and promotion, which can conflict with and negatively influence national HIV/AIDS prevention response efforts. This article reports the findings from a study that explored the factors influencing the HIV/AIDS prevention policy process within faith-based non-governmental organizations (NGOs) of different faiths. These factors were examined within three faith-based NGOs in Dar es Salaam, Tanzania-a Catholic, Anglican and Muslim organization. The research used an exploratory, qualitative case-study approach, and employed a health policy analysis framework, examining the context, actor and process factors and how they interact to form content in terms of policy and its implementation within each organization. Three key factors were found to influence faith-based NGOs' HIV/AIDS prevention response in terms of both policy and its implementation: (1) the faith structure in which the organizations are a part, (2) the presence or absence of organizational policy and (3) the professional nature of the organizations and its actors. The interaction between these factors, and how actors negotiate between them, was found to shape the organizations' HIV/AIDS prevention response. This article reports on these factors and analyses the different HIV/AIDS prevention responses found within each organization. By understanding the factors that influence faith-based NGOs' HIV/AIDS prevention policy process, the overall faith-based response to HIV/AIDS, and how it corresponds to national response efforts, is better understood. It is hoped that by doing so the government will be better able to identify how to best work with FBOs to meet national HIV/AIDS prevention targets, improving the overall role of FBOs in the fight against HIV/AIDS.

EMG-based pattern recognition approach in post stroke robot-aided rehabilitation: a feasibility study

PubMed Central

2013-01-01

Background Several studies investigating the use of electromyographic (EMG) signals in robot-based stroke neuro-rehabilitation to enhance functional recovery. Here we explored whether a classical EMG-based patterns recognition approach could be employed to predict patients’ intentions while attempting to generate goal-directed movements in the horizontal plane. Methods Nine right-handed healthy subjects and seven right-handed stroke survivors performed reaching movements in the horizontal plane. EMG signals were recorded and used to identify the intended motion direction of the subjects. To this aim, a standard pattern recognition algorithm (i.e., Support Vector Machine, SVM) was used. Different tests were carried out to understand the role of the inter- and intra-subjects’ variability in affecting classifier accuracy. Abnormal muscular spatial patterns generating misclassification were evaluated by means of an assessment index calculated from the results achieved with the PCA, i.e., the so-called Coefficient of Expressiveness (CoE). Results Processing the EMG signals of the healthy subjects, in most of the cases we were able to build a static functional map of the EMG activation patterns for point-to-point reaching movements on the horizontal plane. On the contrary, when processing the EMG signals of the pathological subjects a good classification was not possible. In particular, patients’ aimed movement direction was not predictable with sufficient accuracy either when using the general map extracted from data of normal subjects and when tuning the classifier on the EMG signals recorded from each patient. Conclusions The experimental findings herein reported show that the use of EMG patterns recognition approach might not be practical to decode movement intention in subjects with neurological injury such as stroke. Rather than estimate motion from EMGs, future scenarios should encourage the utilization of these signals to detect and interpret the normal and abnormal muscle patterns and provide feedback on their correct recruitment. PMID:23855907

Production of high-fidelity electropherograms results in improved and consistent DNA interpretation: Standardizing the forensic validation process.

PubMed

Peters, Kelsey C; Swaminathan, Harish; Sheehan, Jennifer; Duffy, Ken R; Lun, Desmond S; Grgicak, Catherine M

2017-11-01

Samples containing low-copy numbers of DNA are routinely encountered in casework. The signal acquired from these sample types can be difficult to interpret as they do not always contain all of the genotypic information from each contributor, where the loss of genetic information is associated with sampling and detection effects. The present work focuses on developing a validation scheme to aid in mitigating the effects of the latter. We establish a scheme designed to simultaneously improve signal resolution and detection rates without costly large-scale experimental validation studies by applying a combined simulation and experimental based approach. Specifically, we parameterize an in silico DNA pipeline with experimental data acquired from the laboratory and use this to evaluate multifarious scenarios in a cost-effective manner. Metrics such as signal 1copy -to-noise resolution, false positive and false negative signal detection rates are used to select tenable laboratory parameters that result in high-fidelity signal in the single-copy regime. We demonstrate that the metrics acquired from simulation are consistent with experimental data obtained from two capillary electrophoresis platforms and various injection parameters. Once good resolution is obtained, analytical thresholds can be determined using detection error tradeoff analysis, if necessary. Decreasing the limit of detection of the forensic process to one copy of DNA is a powerful mechanism by which to increase the information content on minor components of a mixture, which is particularly important for probabilistic system inference. If the forensic pipeline is engineered such that high-fidelity electropherogram signal is obtained, then the likelihood ratio (LR) of a true contributor increases and the probability that the LR of a randomly chosen person is greater than one decreases. This is, potentially, the first step towards standardization of the analytical pipeline across operational laboratories. Copyright © 2017 Elsevier B.V. All rights reserved.

Sentence recognition in noise and perceived benefit of noise reduction on the receiver and transmitter sides of a BICROS hearing aid.

PubMed

Oeding, Kristi; Valente, Michael

2013-01-01

In the past, bilateral contralateral routing of signals (BICROS) amplification incorporated omnidirectional microphones on the transmitter and receiver sides and some models utilized noise reduction (NR) on the receiver side. Little research has examined the performance of BICROS amplification in background noise. However, previous studies examining contralateral routing of signals (CROS) amplification have reported that the presence of background noise on the transmitter side negatively affected speech recognition. Recently, NR was introduced as a feature on the receiver and transmitter sides of BICROS amplification, which has the potential to decrease the impact of noise on the wanted speech signal by decreasing unwanted noise directed to the transmitter side. The primary goal of this study was to examine differences in the reception threshold for sentences (RTS in dB) using the Hearing in Noise Test (HINT) in a diffuse listening environment between unaided and three aided BICROS conditions (no NR, mild NR, and maximum NR) in the Tandem 16 BICROS. A secondary goal was to examine real-world subjective impressions of the Tandem 16 BICROS compared to unaided. A randomized block repeated measures single blind design was used to assess differences between no NR, mild NR, and maximum NR listening conditions. Twenty-one adult participants with asymmetric sensorineural hearing loss (ASNHL) and experience with BICROS amplification were recruited from Washington University in St. Louis School of Medicine. Participants were fit with the National Acoustic Laboratories' Nonlinear version 1 prescriptive target (NAL-NL1) with the Tandem 16 BICROS at the initial visit and then verified using real-ear insertion gain (REIG) measures. Participants acclimatized to the Tandem 16 BICROS for 4 wk before returning for final testing. Participants were tested utilizing HINT sentences examining differences in RTS between unaided and three aided listening conditions. Subjective benefit was determined via the Abbreviated Profile of Hearing Aid Benefit (APHAB) questionnaire between the Tandem 16 BICROS and unaided. A repeated measures analysis of variance (ANOVA) was utilized to analyze the results of the HINT and APHAB. Results revealed no significant differences in the RTS between unaided, no NR, mild NR, and maximum NR. Subjective impressions using the APHAB revealed statistically and clinically significant benefit with the Tandem 16 BICROS compared to unaided for the Ease of Communication (EC), Background Noise (BN), and Reverberation (RV) subscales. The RTS was not significantly different between unaided, no NR, mild NR, and maximum NR. None of the three aided listening conditions were significantly different from unaided performance as has been reported for previous studies examining CROS hearing aids. Further, based on comments from participants and previous research studies with conventional hearing aids, manufacturers of BICROS amplification should consider incorporating directional microphones and independent volume controls on the receiver and transmitter sides to potentially provide further improvement in signal-to-noise ratio (SNR) for patients with ASNHL. American Academy of Audiology.

Multi-microphone adaptive array augmented with visual cueing.

PubMed

Gibson, Paul L; Hedin, Dan S; Davies-Venn, Evelyn E; Nelson, Peggy; Kramer, Kevin

2012-01-01

We present the development of an audiovisual array that enables hearing aid users to converse with multiple speakers in reverberant environments with significant speech babble noise where their hearing aids do not function well. The system concept consists of a smartphone, a smartphone accessory, and a smartphone software application. The smartphone accessory concept is a multi-microphone audiovisual array in a form factor that allows attachment to the back of the smartphone. The accessory will also contain a lower power radio by which it can transmit audio signals to compatible hearing aids. The smartphone software application concept will use the smartphone's built in camera to acquire images and perform real-time face detection using the built-in face detection support of the smartphone. The audiovisual beamforming algorithm uses the location of talking targets to improve the signal to noise ratio and consequently improve the user's speech intelligibility. Since the proposed array system leverages a handheld consumer electronic device, it will be portable and low cost. A PC based experimental system was developed to demonstrate the feasibility of an audiovisual multi-microphone array and these results are presented.

Music and Hearing Aids—An Introduction

PubMed Central

2012-01-01

Modern digital hearing aids have provided improved fidelity over those of earlier decades for speech. The same however cannot be said for music. Most modern hearing aids have a limitation of their “front end,” which comprises the analog-to-digital (A/D) converter. For a number of reasons, the spectral nature of music as an input to a hearing aid is beyond the optimal operating conditions of the “front end” components. Amplified music tends to be of rather poor fidelity. Once the music signal is distorted, no amount of software manipulation that occurs later in the circuitry can improve things. The solution is not a software issue. Some characteristics of music that make it difficult to be transduced without significant distortion include an increased sound level relative to that of speech, and the crest factor- the difference in dB between the instantaneous peak of a signal and its RMS value. Clinical strategies and technical innovations have helped to improve the fidelity of amplified music and these include a reduction of the level of the input that is presented to the A/D converter. PMID:23258616

Subspace Dimensionality: A Tool for Automated QC in Seismic Array Processing

NASA Astrophysics Data System (ADS)

Rowe, C. A.; Stead, R. J.; Begnaud, M. L.

2013-12-01

Because of the great resolving power of seismic arrays, the application of automated processing to array data is critically important in treaty verification work. A significant problem in array analysis is the inclusion of bad sensor channels in the beamforming process. We are testing an approach to automated, on-the-fly quality control (QC) to aid in the identification of poorly performing sensor channels prior to beam-forming in routine event detection or location processing. The idea stems from methods used for large computer servers, when monitoring traffic at enormous numbers of nodes is impractical on a node-by node basis, so the dimensionality of the node traffic is instead monitoried for anomalies that could represent malware, cyber-attacks or other problems. The technique relies upon the use of subspace dimensionality or principal components of the overall system traffic. The subspace technique is not new to seismology, but its most common application has been limited to comparing waveforms to an a priori collection of templates for detecting highly similar events in a swarm or seismic cluster. In the established template application, a detector functions in a manner analogous to waveform cross-correlation, applying a statistical test to assess the similarity of the incoming data stream to known templates for events of interest. In our approach, we seek not to detect matching signals, but instead, we examine the signal subspace dimensionality in much the same way that the method addresses node traffic anomalies in large computer systems. Signal anomalies recorded on seismic arrays affect the dimensional structure of the array-wide time-series. We have shown previously that this observation is useful in identifying real seismic events, either by looking at the raw signal or derivatives thereof (entropy, kurtosis), but here we explore the effects of malfunctioning channels on the dimension of the data and its derivatives, and how to leverage this effect for identifying bad array elements through a jackknifing process to isolate the anomalous channels, so that an automated analysis system might discard them prior to FK analysis and beamforming on events of interest.

Computational identification of signalling pathways in Plasmodium falciparum.

PubMed

Oyelade, Jelili; Ewejobi, Itunu; Brors, Benedikt; Eils, Roland; Adebiyi, Ezekiel

2011-06-01

Malaria is one of the world's most common and serious diseases causing death of about 3 million people each year. Its most severe occurrence is caused by the protozoan Plasmodium falciparum. Reports have shown that the resistance of the parasite to existing drugs is increasing. Therefore, there is a huge and urgent need to discover and validate new drug or vaccine targets to enable the development of new treatments for malaria. The ability to discover these drug or vaccine targets can only be enhanced from our deep understanding of the detailed biology of the parasite, for example how cells function and how proteins organize into modules such as metabolic, regulatory and signal transduction pathways. It has been noted that the knowledge of signalling transduction pathways in Plasmodium is fundamental to aid the design of new strategies against malaria. This work uses a linear-time algorithm for finding paths in a network under modified biologically motivated constraints. We predicted several important signalling transduction pathways in Plasmodium falciparum. We have predicted a viable signalling pathway characterized in terms of the genes responsible that may be the PfPKB pathway recently elucidated in Plasmodium falciparum. We obtained from the FIKK family, a signal transduction pathway that ends up on a chloroquine resistance marker protein, which indicates that interference with FIKK proteins might reverse Plasmodium falciparum from resistant to sensitive phenotype. We also proposed a hypothesis that showed the FIKK proteins in this pathway as enabling the resistance parasite to have a mechanism for releasing chloroquine (via an efflux process). Furthermore, we also predicted a signalling pathway that may have been responsible for signalling the start of the invasion process of Red Blood Cell (RBC) by the merozoites. It has been noted that the understanding of this pathway will give insight into the parasite virulence and will facilitate rational vaccine design against merozoites invasion. And we have a host of other predicted pathways, some of which have been used in this work to predict the functionality of some proteins. Copyright © 2010 Elsevier B.V. All rights reserved.

Situation-Assessment And Decision-Aid Production-Rule Analysis System For Nuclear Plant Monitoring And Emergency Preparedness

NASA Astrophysics Data System (ADS)

Gvillo, D.; Ragheb, M.; Parker, M.; Swartz, S.

1987-05-01

A Production-Rule Analysis System is developed for Nuclear Plant Monitoring. The signals generated by the Zion-1 Plant are considered. A Situation-Assessment and Decision-Aid capability is provided for monitoring the integrity of the Plant Radiation, the Reactor Coolant, the Fuel Clad, and the Containment Systems. A total of 41 signals are currently fed as facts to an Inference Engine functioning in the backward-chaining mode and built along the same structure as the E-Mycin system. The Goal-Tree constituting the Knowledge Base was generated using a representation in the form of Fault Trees deduced from plant procedures information. The system is constructed in support of the Data Analysis and Emergency Preparedness tasks at the Illinois Radiological Emergency Assessment Center (REAC).

Intelligent Network Management and Functional Cerebellum Synthesis

NASA Technical Reports Server (NTRS)

Loebner, Egon E.

1989-01-01

Transdisciplinary modeling of the cerebellum across histology, physiology, and network engineering provides preliminary results at three organization levels: input/output links to central nervous system networks; links between the six neuron populations in the cerebellum; and computation among the neurons of the populations. Older models probably underestimated the importance and role of climbing fiber input which seems to supply write as well as read signals, not just to Purkinje but also to basket and stellate neurons. The well-known mossy fiber-granule cell-Golgi cell system should also respond to inputs originating from climbing fibers. Corticonuclear microcomplexing might be aided by stellate and basket computation and associate processing. Technological and scientific implications of the proposed cerebellum model are discussed.

A new VOX technique for reducing noise in voice communication systems. [voice operated keying

NASA Technical Reports Server (NTRS)

Morris, C. F.; Morgan, W. C.; Shack, P. E.

1974-01-01

A VOX technique for reducing noise in voice communication systems is described which is based on the separation of voice signals into contiguous frequency-band components with the aid of an adaptive VOX in each band. It is shown that this processing scheme can effectively reduce both wideband and narrowband quasi-periodic noise since the threshold levels readjust themselves to suppress noise that exceeds speech components in each band. Results are reported for tests of the adaptive VOX, and it is noted that improvements can still be made in such areas as the elimination of noise pulses, phoneme reproduction at high-noise levels, and the elimination of distortion introduced by phase delay.

Role of interleukin-22 in inflammatory bowel disease.

PubMed

Li, Lin-Jing; Gong, Chen; Zhao, Mei-Hua; Feng, Bai-Sui

2014-12-28

Inflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by the microbiota of the intestinal lumen and inappropriate immune responses. Aberrant immune responses can cause secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract, leading to further inflammation. Interleukin (IL)-22 is a member of the IL-10 family of cytokines that was recently discovered to be mainly produced by both adaptive and innate immune cells. Several cytokines and many of the transcriptional factors and T regulatory cells are known to regulate IL-22 expression through activation of signal transducer and activator of transcription 3 signaling cascades. This cytokine induces antimicrobial molecules and proliferative and antiapoptotic pathways, which help prevent tissue damage and aid in its repair. All of these processes play a beneficial role in IBD by enhancing intestinal barrier integrity and epithelial innate immunity. In this review, we discuss recent progress in the involvement of IL-22 in the pathogenesis of IBD, as well as its therapeutic potential.

Advanced Integration of WiFi and Inertial Navigation Systems for Indoor Mobile Positioning

NASA Astrophysics Data System (ADS)

Evennou, Frédéric; Marx, François

2006-12-01

This paper presents an aided dead-reckoning navigation structure and signal processing algorithms for self localization of an autonomous mobile device by fusing pedestrian dead reckoning and WiFi signal strength measurements. WiFi and inertial navigation systems (INS) are used for positioning and attitude determination in a wide range of applications. Over the last few years, a number of low-cost inertial sensors have become available. Although they exhibit large errors, WiFi measurements can be used to correct the drift weakening the navigation based on this technology. On the other hand, INS sensors can interact with the WiFi positioning system as they provide high-accuracy real-time navigation. A structure based on a Kalman filter and a particle filter is proposed. It fuses the heterogeneous information coming from those two independent technologies. Finally, the benefits of the proposed architecture are evaluated and compared with the pure WiFi and INS positioning systems.

Conceptual Design of a Communication-Based Deep Space Navigation Network

NASA Technical Reports Server (NTRS)

Anzalone, Evan J.; Chuang, C. H.

2012-01-01

As the need grows for increased autonomy and position knowledge accuracy to support missions beyond Earth orbit, engineers must push and develop more advanced navigation sensors and systems that operate independent of Earth-based analysis and processing. Several spacecraft are approaching this problem using inter-spacecraft radiometric tracking and onboard autonomous optical navigation methods. This paper proposes an alternative implementation to aid in spacecraft position fixing. The proposed method Network-Based Navigation technique takes advantage of the communication data being sent between spacecraft and between spacecraft and ground control to embed navigation information. The navigation system uses these packets to provide navigation estimates to an onboard navigation filter to augment traditional ground-based radiometric tracking techniques. As opposed to using digital signal measurements to capture inherent information of the transmitted signal itself, this method relies on the embedded navigation packet headers to calculate a navigation estimate. This method is heavily dependent on clock accuracy and the initial results show the promising performance of a notional system.

Dynamic Range Across Music Genres and the Perception of Dynamic Compression in Hearing-Impaired Listeners

PubMed Central

Kirchberger, Martin

2016-01-01

Dynamic range compression serves different purposes in the music and hearing-aid industries. In the music industry, it is used to make music louder and more attractive to normal-hearing listeners. In the hearing-aid industry, it is used to map the variable dynamic range of acoustic signals to the reduced dynamic range of hearing-impaired listeners. Hence, hearing-aided listeners will typically receive a dual dose of compression when listening to recorded music. The present study involved an acoustic analysis of dynamic range across a cross section of recorded music as well as a perceptual study comparing the efficacy of different compression schemes. The acoustic analysis revealed that the dynamic range of samples from popular genres, such as rock or rap, was generally smaller than the dynamic range of samples from classical genres, such as opera and orchestra. By comparison, the dynamic range of speech, based on recordings of monologues in quiet, was larger than the dynamic range of all music genres tested. The perceptual study compared the effect of the prescription rule NAL-NL2 with a semicompressive and a linear scheme. Music subjected to linear processing had the highest ratings for dynamics and quality, followed by the semicompressive and the NAL-NL2 setting. These findings advise against NAL-NL2 as a prescription rule for recorded music and recommend linear settings. PMID:26868955

Dynamic Range Across Music Genres and the Perception of Dynamic Compression in Hearing-Impaired Listeners.

PubMed

Kirchberger, Martin; Russo, Frank A

2016-02-10

Dynamic range compression serves different purposes in the music and hearing-aid industries. In the music industry, it is used to make music louder and more attractive to normal-hearing listeners. In the hearing-aid industry, it is used to map the variable dynamic range of acoustic signals to the reduced dynamic range of hearing-impaired listeners. Hence, hearing-aided listeners will typically receive a dual dose of compression when listening to recorded music. The present study involved an acoustic analysis of dynamic range across a cross section of recorded music as well as a perceptual study comparing the efficacy of different compression schemes. The acoustic analysis revealed that the dynamic range of samples from popular genres, such as rock or rap, was generally smaller than the dynamic range of samples from classical genres, such as opera and orchestra. By comparison, the dynamic range of speech, based on recordings of monologues in quiet, was larger than the dynamic range of all music genres tested. The perceptual study compared the effect of the prescription rule NAL-NL2 with a semicompressive and a linear scheme. Music subjected to linear processing had the highest ratings for dynamics and quality, followed by the semicompressive and the NAL-NL2 setting. These findings advise against NAL-NL2 as a prescription rule for recorded music and recommend linear settings. © The Author(s) 2016.

Microwave processing of a dental ceramic used in computer-aided design/computer-aided manufacturing.

PubMed

Pendola, Martin; Saha, Subrata

2015-01-01

Because of their favorable mechanical properties and natural esthetics, ceramics are widely used in restorative dentistry. The conventional ceramic sintering process required for their use is usually slow, however, and the equipment has an elevated energy consumption. Sintering processes that use microwaves have several advantages compared to regular sintering: shorter processing times, lower energy consumption, and the capacity for volumetric heating. The objective of this study was to test the mechanical properties of a dental ceramic used in computer-aided design/computer-aided manufacturing (CAD/CAM) after the specimens were processed with microwave hybrid sintering. Density, hardness, and bending strength were measured. When ceramic specimens were sintered with microwaves, the processing times were reduced and protocols were simplified. Hardness was improved almost 20% compared to regular sintering, and flexural strength measurements suggested that specimens were approximately 50% stronger than specimens sintered in a conventional system. Microwave hybrid sintering may preserve or improve the mechanical properties of dental ceramics designed for CAD/CAM processing systems, reducing processing and waiting times.

Subjective and objective outcomes from new BiCROS technology in a veteran sample.

PubMed

Williams, Victoria A; McArdle, Rachel A; Chisolm, Theresa H

2012-01-01

Patients with single-sided deafness (SSD), where one ear has an unaidable hearing loss and the other ear has normal or aidable hearing, often complain of difficulties understanding speech and localizing sound sources, and report a higher self-perceived hearing disability. Patients with SSD may benefit from using contralateral routing of signal (CROS) or bilateral contralateral routing of the signal (BiCROS) amplification. Dissatisfaction of previously available (Bi)CROS devices has been reported, such as, interfering transmissions, low-fidelity sound quality, poor "user-friendly" set-up, and a bulky and cosmetically cumbersome appearance. Recent advances in hearing aid technology have improved (Bi)CROS hearing aids; however, these devices have not been experimentally evaluated. We hypothesized that newer technology with reports of improved digital signal processing, wireless transmission, and physical design would be as good, or better than, our participants' previous-generation BiCROS systems. A within-subjects, pretest-posttest design was executed. Thirty-nine veterans (one female, 38 males; mean age = 74 yr, range = 49-85 yr) from the Audiology Section of the Bay Pines Veterans Affair Healthcare System participated. All participants were previously experienced BiCROS hearing aid users with varying degrees of sensorinerual hearing impairment in their better ear. Participants were provided at least 4 wk of consistent use with the new BiCROS. DATA COLLECTION AND ANALYSES: Participants completed three research visits. At Visit 1, with their previous BiCROS, and at Visit 3, with their new BiCROS, the following objective and subjective measures were obtained: (1) soundfield speech-in-noise testing using the Words-In-Noise (WIN) test; (2) speech, spatial, and qualities of the hearing scale (SSQ) questionnaire; (3) selected questions from the MarkeTrak questionnaire; and, (4) three open-ended questions. Data were analyzed using parametric and nonparametric statistics. Overall, the objective (WIN) and subjective (SSQ, MarkeTrak, and open-ended questions) measures indicated that the new BiCROS provided better outcomes than the previous BiCROS system. In addition, an overlap of favorable results was seen across measures. Of the 39 participants, 95% reported improvements with the new BiCROS and chose to utilize the device regularly. The favorable objective and subjective outcomes indicate that the new BiCROS system is as good, or better than, what was previously utilized by our sample of veterans. American Academy of Audiology.

Reversal of age-related neural timing delays with training

PubMed Central

Anderson, Samira; White-Schwoch, Travis; Parbery-Clark, Alexandra; Kraus, Nina

2013-01-01

Neural slowing is commonly noted in older adults, with consequences for sensory, motor, and cognitive domains. One of the deleterious effects of neural slowing is impairment of temporal resolution; older adults, therefore, have reduced ability to process the rapid events that characterize speech, especially in noisy environments. Although hearing aids provide increased audibility, they cannot compensate for deficits in auditory temporal processing. Auditory training may provide a strategy to address these deficits. To that end, we evaluated the effects of auditory-based cognitive training on the temporal precision of subcortical processing of speech in noise. After training, older adults exhibited faster neural timing and experienced gains in memory, speed of processing, and speech-in-noise perception, whereas a matched control group showed no changes. Training was also associated with decreased variability of brainstem response peaks, suggesting a decrease in temporal jitter in response to a speech signal. These results demonstrate that auditory-based cognitive training can partially restore age-related deficits in temporal processing in the brain; this plasticity in turn promotes better cognitive and perceptual skills. PMID:23401541

Federal Student Aid Handbook with Active Index, 2015-2016

ERIC Educational Resources Information Center

Federal Student Aid, US Department of Education, 2016

2016-01-01

This publication is intended for financial aid administrators and counselors who help students begin the aid process--filing the Free Application for Federal Student Aid (FAFSA®), verifying information, and making corrections and other changes to the information reported on the FAFSA. The Federal Student Aid Handbook consists of the Application…

Financial Aid's Role in Meeting State College Completion Goals

ERIC Educational Resources Information Center

Hillman, Nicholas W.; Orians, Erica Lee

2013-01-01

This brief utilizes the most recent and rigorous financial aid research to inform state higher education leaders about innovative and effective financial aid practices. By simplifying aid eligibility requirements, improving the aid application process, and engaging in early awareness efforts, states could improve the effectiveness of existing aid…

Speech recognition for bilaterally asymmetric and symmetric hearing aid microphone modes in simulated classroom environments.

PubMed

Ricketts, Todd A; Picou, Erin M

2013-09-01

This study aimed to evaluate the potential utility of asymmetrical and symmetrical directional hearing aid fittings for school-age children in simulated classroom environments. This study also aimed to evaluate speech recognition performance of children with normal hearing in the same listening environments. Two groups of school-age children 11 to 17 years of age participated in this study. Twenty participants had normal hearing, and 29 participants had sensorineural hearing loss. Participants with hearing loss were fitted with behind-the-ear hearing aids with clinically appropriate venting and were tested in 3 hearing aid configurations: bilateral omnidirectional, bilateral directional, and asymmetrical directional microphones. Speech recognition testing was completed in each microphone configuration in 3 environments: Talker-Front, Talker-Back, and Question-Answer situations. During testing, the location of the speech signal changed, but participants were always seated in a noisy, moderately reverberant classroom-like room. For all conditions, results revealed expected effects of directional microphones on speech recognition performance. When the signal of interest was in front of the listener, bilateral directional microphone was best, and when the signal of interest was behind the listener, bilateral omnidirectional microphone was best. Performance with asymmetric directional microphones was between the 2 symmetrical conditions. The magnitudes of directional benefits and decrements were not significantly correlated. In comparison with their peers with normal hearing, children with hearing loss performed similarly to their peers with normal hearing when fitted with directional microphones and the speech was from the front. In contrast, children with normal hearing still outperformed children with hearing loss if the speech originated from behind, even when the children were fitted with the optimal hearing aid microphone mode for the situation. Bilateral directional microphones can be effective in improving speech recognition performance for children in the classroom, as long as child is facing the talker of interest. Bilateral directional microphones, however, can impair performance if the signal originates from behind a listener. However, these data suggest that the magnitude of decrement is not predictable from an individual's benefit. The results re-emphasize the importance of appropriate switching between microphone modes so children can take full advantage of directional benefits without being hurt by directional decrements. An asymmetric fitting limits decrements, but does not lead to maximum speech recognition scores when compared with the optimal symmetrical fitting. Therefore, the asymmetric mode may not be the best option as a default fitting for children in a classroom environment. While directional microphones improve performance for children with hearing loss, their performance in most conditions continues to be impaired relative to their normal-hearing peers, particularly when the signals of interest originate from behind or from an unpredictable location.

Calibrated Noise Measurements with Induced Receiver Gain Fluctuations

NASA Technical Reports Server (NTRS)

Racette, Paul; Walker, David; Gu, Dazhen; Rajola, Marco; Spevacek, Ashly

2011-01-01

The lack of well-developed techniques for modeling changing statistical moments in our observations has stymied the application of stochastic process theory in science and engineering. These limitations were encountered when modeling the performance of radiometer calibration architectures and algorithms in the presence of non stationary receiver fluctuations. Analyses of measured signals have traditionally been limited to a single measurement series. Whereas in a radiometer that samples a set of noise references, the data collection can be treated as an ensemble set of measurements of the receiver state. Noise Assisted Data Analysis is a growing field of study with significant potential for aiding the understanding and modeling of non stationary processes. Typically, NADA entails adding noise to a signal to produce an ensemble set on which statistical analysis is performed. Alternatively as in radiometric measurements, mixing a signal with calibrated noise provides, through the calibration process, the means to detect deviations from the stationary assumption and thereby a measurement tool to characterize the signal's non stationary properties. Data sets comprised of calibrated noise measurements have been limited to those collected with naturally occurring fluctuations in the radiometer receiver. To examine the application of NADA using calibrated noise, a Receiver Gain Modulation Circuit (RGMC) was designed and built to modulate the gain of a radiometer receiver using an external signal. In 2010, an RGMC was installed and operated at the National Institute of Standards and Techniques (NIST) using their Noise Figure Radiometer (NFRad) and national standard noise references. The data collected is the first known set of calibrated noise measurements from a receiver with an externally modulated gain. As an initial step, sinusoidal and step-function signals were used to modulate the receiver gain, to evaluate the circuit characteristics and to study the performance of a variety of calibration algorithms. The receiver noise temperature and time-bandwidth product of the NFRad are calculated from the data. Statistical analysis using temporal-dependent calibration algorithms reveals that the natural occurring fluctuations in the receiver are stationary over long intervals (100s of seconds); however the receiver exhibits local non stationarity over the interval over which one set of reference measurements are collected. A variety of calibration algorithms have been applied to the data to assess algorithms' performance with the gain fluctuation signals. This presentation will describe the RGMC, experiment design and a comparative analysis of calibration algorithms.

The Politics of Determining Merit Aid Eligibility Criteria: An Analysis of the Policy Process

ERIC Educational Resources Information Center

Ness, Erik C.

2010-01-01

Despite the scholarly attention on the effects of merit aid on college access and choice, particularly on the significant effect that states' varied eligibility criteria play, no studies have examined the policy process through which merit aid criteria are determined. This is surprising given the recent attention to state-level policy dynamics and…

40 CFR 170.232 - Knowledge of labeling and site-specific information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements related to safe use of the pesticide, such as signal words, human hazard precautions, personal protective equipment requirements, first aid instructions, environmental precautions, and any additional...

40 CFR 170.232 - Knowledge of labeling and site-specific information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements related to safe use of the pesticide, such as signal words, human hazard precautions, personal protective equipment requirements, first aid instructions, environmental precautions, and any additional...

32 CFR 707.6 - Minesweeping station keeping lights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.6 Minesweeping station keeping lights. Naval vessels engaged in minesweeping operations may display, as an aid in maintaining prescribed...

Algorithms for Image Analysis and Combination of Pattern Classifiers with Application to Medical Diagnosis

NASA Astrophysics Data System (ADS)

Georgiou, Harris

2009-10-01

Medical Informatics and the application of modern signal processing in the assistance of the diagnostic process in medical imaging is one of the more recent and active research areas today. This thesis addresses a variety of issues related to the general problem of medical image analysis, specifically in mammography, and presents a series of algorithms and design approaches for all the intermediate levels of a modern system for computer-aided diagnosis (CAD). The diagnostic problem is analyzed with a systematic approach, first defining the imaging characteristics and features that are relevant to probable pathology in mammo-grams. Next, these features are quantified and fused into new, integrated radio-logical systems that exhibit embedded digital signal processing, in order to improve the final result and minimize the radiological dose for the patient. In a higher level, special algorithms are designed for detecting and encoding these clinically interest-ing imaging features, in order to be used as input to advanced pattern classifiers and machine learning models. Finally, these approaches are extended in multi-classifier models under the scope of Game Theory and optimum collective deci-sion, in order to produce efficient solutions for combining classifiers with minimum computational costs for advanced diagnostic systems. The material covered in this thesis is related to a total of 18 published papers, 6 in scientific journals and 12 in international conferences.

Target acquisition modeling over the exact optical path: extending the EOSTAR TDA with the TOD sensor performance model

NASA Astrophysics Data System (ADS)

Dijk, J.; Bijl, P.; Oppeneer, M.; ten Hove, R. J. M.; van Iersel, M.

2017-10-01

The Electro-Optical Signal Transmission and Ranging (EOSTAR) model is an image-based Tactical Decision Aid (TDA) for thermal imaging systems (MWIR/LWIR) developed for a sea environment with an extensive atmosphere model. The Triangle Orientation Discrimination (TOD) Target Acquisition model calculates the sensor and signal processing effects on a set of input triangle test pattern images, judges their orientation using humans or a Human Visual System (HVS) model and derives the system image quality and operational field performance from the correctness of the responses. Combination of the TOD model and EOSTAR, basically provides the possibility to model Target Acquisition (TA) performance over the exact path from scene to observer. In this method ship representative TOD test patterns are placed at the position of the real target, subsequently the combined effects of the environment (atmosphere, background, etc.), sensor and signal processing on the image are calculated using EOSTAR and finally the results are judged by humans. The thresholds are converted into Detection-Recognition-Identification (DRI) ranges of the real target. In experiments is shown that combination of the TOD model and the EOSTAR model is indeed possible. The resulting images look natural and provide insight in the possibilities of combining the two models. The TOD observation task can be done well by humans, and the measured TOD is consistent with analytical TOD predictions for the same camera that was modeled in the ECOMOS project.

Early Bimodal Stimulation Benefits Language Acquisition for Children With Cochlear Implants.

PubMed

Moberly, Aaron C; Lowenstein, Joanna H; Nittrouer, Susan

2016-01-01

Adding a low-frequency acoustic signal to the cochlear implant (CI) signal (i.e., bimodal stimulation) for a period of time early in life improves language acquisition. Children must acquire sensitivity to the phonemic units of language to develop most language-related skills, including expressive vocabulary, working memory, and reading. Acquiring sensitivity to phonemic structure depends largely on having refined spectral (frequency) representations available in the signal, which does not happen with CIs alone. Combining the low-frequency acoustic signal available through hearing aids with the CI signal can enhance signal quality. A period with this bimodal stimulation has been shown to improve language skills in very young children. This study examined whether these benefits persist into childhood. Data were examined for 48 children with CIs implanted under age 3 years, participating in a longitudinal study. All children wore hearing aids before receiving a CI, but upon receiving a first CI, 24 children had at least 1 year of bimodal stimulation (Bimodal group), and 24 children had only electric stimulation subsequent to implantation (CI-only group). Measures of phonemic awareness were obtained at second and fourth grades, along with measures of expressive vocabulary, working memory, and reading. Children in the Bimodal group generally performed better on measures of phonemic awareness, and that advantage was reflected in other language measures. Having even a brief period of time early in life with combined electric-acoustic input provides benefits to language learning into childhood, likely because of the enhancement in spectral representations provided.

Cutaneous sensory nerve as a substitute for auditory nerve in solving deaf-mutes’ hearing problem: an innovation in multi-channel-array skin-hearing technology

PubMed Central

Li, Jianwen; Li, Yan; Zhang, Ming; Ma, Weifang; Ma, Xuezong

2014-01-01

The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice signals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequency analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to distinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes’ hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized. PMID:25317171

[2010-2011 Federal Student Aid Handbook with Active Index

ERIC Educational Resources Information Center

Federal Student Aid, US Department of Education, 2011

2011-01-01

This publication is intended for financial aid administrators and counselors who help students begin the aid process--filing the Free Application for Federal Student Aid (FAFSA), verifying information, and making corrections and other changes to the information reported on the FAFSA. The Federal Student Aid Handbook consists of the Application and…

Effects of response bias and judgment framing on operator use of an automated aid in a target detection task.

PubMed

Rice, Stephen; McCarley, Jason S

2011-12-01

Automated diagnostic aids prone to false alarms often produce poorer human performance in signal detection tasks than equally reliable miss-prone aids. However, it is not yet clear whether this is attributable to differences in the perceptual salience of the automated aids' misses and false alarms or is the result of inherent differences in operators' cognitive responses to different forms of automation error. The present experiments therefore examined the effects of automation false alarms and misses on human performance under conditions in which the different forms of error were matched in their perceptual characteristics. Young adult participants performed a simulated baggage x-ray screening task while assisted by an automated diagnostic aid. Judgments from the aid were rendered as text messages presented at the onset of each trial, and every trial was followed by a second text message providing response feedback. Thus, misses and false alarms from the aid were matched for their perceptual salience. Experiment 1 found that even under these conditions, false alarms from the aid produced poorer human performance and engendered lower automation use than misses from the aid. Experiment 2, however, found that the asymmetry between misses and false alarms was reduced when the aid's false alarms were framed as neutral messages rather than explicit misjudgments. Results suggest that automation false alarms and misses differ in their inherent cognitive salience and imply that changes in diagnosis framing may allow designers to encourage better use of imperfectly reliable automated aids.

Infrasonic tremor wavefield of the Pu`u `Ō`ō crater complex and lava tube system, Hawaii, in April 2007

NASA Astrophysics Data System (ADS)

Matoza, Robin S.; Fee, David; GarcéS, Milton A.

2010-12-01

Long-lived effusive volcanism at the Pu`u `Ō`ō crater complex, Kilauea Volcano, Hawaii produces persistent infrasonic tremor that has been recorded almost continuously for months to years. Previous studies showed that this infrasonic tremor wavefield can be recorded at a range of >10 km. However, the low signal power of this tremor relative to ambient noise levels results in significant propagation effects on signal detectability at this range. In April 2007, we supplemented a broadband infrasound array at ˜12.5 km from Pu`u `Ō`ō (MENE) with a similar array at ˜2.4 km from the source (KIPU). The additional closer-range data enable further evaluation of tropospheric propagation effects and provide higher signal-to-noise ratios for studying volcanic source processes. The infrasonic tremor source appears to consist of at least two separate physical processes. We suggest that bubble cloud oscillation in a roiling magma conduit beneath the crater complex may produce a broadband component of the tremor. Low-frequency sound sourced in a shallow magma conduit may radiate infrasound efficiently into the atmosphere due to the anomalous transparency of the magma-air interface. We further propose that more sharply peaked tones with complex temporal evolution may result from oscillatory interactions of a low-velocity gas jet with solid vent boundaries in a process analogous to the hole tone or whistler nozzle. The infrasonic tremor arrives with a median azimuth of ˜67° at KIPU. Additional infrasonic signals and audible sounds originating from the extended lava tube system to the south of the crater complex (median azimuth ˜77°) coincided with turbulent degassing activity at a new lava tube skylight. Our observations indicate that acoustic studies may aid in understanding persistent continuous degassing and unsteady flow dynamics at Kilauea Volcano.

Binaural noise reduction via cue-preserving MMSE filter and adaptive-blocking-based noise PSD estimation

NASA Astrophysics Data System (ADS)

Azarpour, Masoumeh; Enzner, Gerald

2017-12-01

Binaural noise reduction, with applications for instance in hearing aids, has been a very significant challenge. This task relates to the optimal utilization of the available microphone signals for the estimation of the ambient noise characteristics and for the optimal filtering algorithm to separate the desired speech from the noise. The additional requirements of low computational complexity and low latency further complicate the design. A particular challenge results from the desired reconstruction of binaural speech input with spatial cue preservation. The latter essentially diminishes the utility of multiple-input/single-output filter-and-sum techniques such as beamforming. In this paper, we propose a comprehensive and effective signal processing configuration with which most of the aforementioned criteria can be met suitably. This relates especially to the requirement of efficient online adaptive processing for noise estimation and optimal filtering while preserving the binaural cues. Regarding noise estimation, we consider three different architectures: interaural (ITF), cross-relation (CR), and principal-component (PCA) target blocking. An objective comparison with two other noise PSD estimation algorithms demonstrates the superiority of the blocking-based noise estimators, especially the CR-based and ITF-based blocking architectures. Moreover, we present a new noise reduction filter based on minimum mean-square error (MMSE), which belongs to the class of common gain filters, hence being rigorous in terms of spatial cue preservation but also efficient and competitive for the acoustic noise reduction task. A formal real-time subjective listening test procedure is also developed in this paper. The proposed listening test enables a real-time assessment of the proposed computationally efficient noise reduction algorithms in a realistic acoustic environment, e.g., considering time-varying room impulse responses and the Lombard effect. The listening test outcome reveals that the signals processed by the blocking-based algorithms are significantly preferred over the noisy signal in terms of instantaneous noise attenuation. Furthermore, the listening test data analysis confirms the conclusions drawn based on the objective evaluation.

Study on the description method of upper limb's muscle force levels during simulated in-orbit operations

NASA Astrophysics Data System (ADS)

Zhao, Yan; Li, DongXu; Liu, ZhiZhen; Liu, Liang

2013-03-01

The dexterous upper limb serves as the most important tool for astronauts to implement in-orbit experiments and operations. This study developed a simulated weightlessness experiment and invented new measuring equipment to quantitatively evaluate the muscle ability of the upper limb. Isometric maximum voluntary contractions (MVCs) and surface electromyography (sEMG) signals of right-handed pushing at the three positions were measured for eleven subjects. In order to enhance the comprehensiveness and accuracy of muscle force assessment, the study focused on signal processing techniques. We applied a combination method, which consists of time-, frequency-, and bi-frequency-domain analyses. Time- and frequency-domain analyses estimated the root mean square (RMS) and median frequency (MDF) of sEMG signals, respectively. Higher order spectra (HOS) of bi-frequency domain evaluated the maximum bispectrum amplitude ( B max), Gaussianity level (Sg) and linearity level (S l ) of sEMG signals. Results showed that B max, S l , and RMS values all increased as force increased. MDF and Sg values both declined as force increased. The research demonstrated that the combination method is superior to the conventional time- and frequency-domain analyses. The method not only described sEMG signal amplitude and power spectrum, but also deeper characterized phase coupling information and non-Gaussianity and non-linearity levels of sEMG, compared to two conventional analyses. The finding from the study can aid ergonomist to estimate astronaut muscle performance, so as to optimize in-orbit operation efficacy and minimize musculoskeletal injuries.

Age-dependent atrophy and microgravity travel: what do they have in common?

PubMed

Wang, E

1999-01-01

Space travel and extending human lifespan are two of the many advances of the twentieth century. However, both of these scientific wonders exact a price for their gains; i.e. deleterious effects on normal physiological processes. For example, both old age and prolonged microgravity travel are associated with atrophy in heart, muscle, and bone. The underlying signal transduction pathways, the control mechanisms for the processes of proliferation, differentiation, and apoptosis, may prove to be similarly altered in both old age and microgravity travel. We suggest that the mechanical events involved in space travel provide a telescopic compression of lifespan changes in these tissues; if so, space travel provides an excellent opportunity to investigate how long-term degeneration occurs on Earth. With the aid of biochip technology for multi-factorial analysis, a platform can be generated to create therapeutic modalities to contain, retard, reduce, or prevent this tissue atrophy, either in space or on Earth.

A survey of camera error sources in machine vision systems

NASA Astrophysics Data System (ADS)

Jatko, W. B.

In machine vision applications, such as an automated inspection line, television cameras are commonly used to record scene intensity in a computer memory or frame buffer. Scene data from the image sensor can then be analyzed with a wide variety of feature-detection techniques. Many algorithms found in textbooks on image processing make the implicit simplifying assumption of an ideal input image with clearly defined edges and uniform illumination. The ideal image model is helpful to aid the student in understanding the principles of operation, but when these algorithms are blindly applied to real-world images the results can be unsatisfactory. This paper examines some common measurement errors found in camera sensors and their underlying causes, and possible methods of error compensation. The role of the camera in a typical image-processing system is discussed, with emphasis on the origination of signal distortions. The effects of such things as lighting, optics, and sensor characteristics are considered.

A tool for hearing aid and cochlear implant users to judge the usability of cellular telephones in field conditions

NASA Astrophysics Data System (ADS)

Deer, Maria Soledad

The auditory experience of using a hearing aid or a cochlear implant simultaneously with a cell phone is driven by a number of factors. These factors are: radiofrequency and baseband interference, speech intelligibility, sound quality, handset design, volume control and signal strength. The purpose of this study was to develop a tool to be used by hearing aid and cochlear implant users in retail stores as they try cell phones before buying them. This tool is meant to be an efficient, practical and systematic consumer selection tool that will capture and document information on all the domains that play a role in the auditory experience of using a cell phone with a hearing aid or cochlear implant. The development of this consumer tool involved three steps as follows: preparation, verification and measurement of success according to a predefined criterion. First, the consumer tool, consisting of a comparison chart and speech material, was prepared. Second, the consumer tool was evaluated by groups of subjects in a two-step verification process. Phase I was conducted in a controlled setting and it was followed by Phase II which took place in real world (field) conditions. In order to perform a systematic evaluation of the consumer tool two questionnaires were developed: one questionnaire for each phase. Both questionnaires involved five quantitative variables scored with the use of ratings scales. These ratings were averaged yielding an Overall Consumer Performance Score. A qualitative performance category corresponding to the Mean Opinion Score (MOS) was allocated to each final score within a scale ranging from 1 to 5 (where 5 = excellent and 1 = bad). Finally, the consumer tool development was determined to be successful if at least 80% of the participants in verification Phase II rated the comparison chart as excellent or good according to the qualitative MOS score. The results for verification Phase II (field conditions) indicated that the Overall Consumer Performance score for 92% of the subjects (11/12) was 3.7 and above corresponding to Good and Excellent MOS qualitative categories. It was concluded that this is a practical and efficient tool for hearing aid/cochlear implant users as they approach a cell phone selection process.

Advanced end-to-end fiber optic sensing systems for demanding environments

NASA Astrophysics Data System (ADS)

Black, Richard J.; Moslehi, Behzad

2010-09-01

Optical fibers are small-in-diameter, light-in-weight, electromagnetic-interference immune, electrically passive, chemically inert, flexible, embeddable into different materials, and distributed-sensing enabling, and can be temperature and radiation tolerant. With appropriate processing and/or packaging, they can be very robust and well suited to demanding environments. In this paper, we review a range of complete end-to-end fiber optic sensor systems that IFOS has developed comprising not only (1) packaged sensors and mechanisms for integration with demanding environments, but (2) ruggedized sensor interrogators, and (3) intelligent decision aid algorithms software systems. We examine the following examples: " Fiber Bragg Grating (FBG) optical sensors systems supporting arrays of environmentally conditioned multiplexed FBG point sensors on single or multiple optical fibers: In conjunction with advanced signal processing, decision aid algorithms and reasoners, FBG sensor based structural health monitoring (SHM) systems are expected to play an increasing role in extending the life and reducing costs of new generations of aerospace systems. Further, FBG based structural state sensing systems have the potential to considerably enhance the performance of dynamic structures interacting with their environment (including jet aircraft, unmanned aerial vehicles (UAVs), and medical or extravehicular space robots). " Raman based distributed temperature sensing systems: The complete length of optical fiber acts as a very long distributed sensor which may be placed down an oil well or wrapped around a cryogenic tank.

USE OF COMPUTER-AIDED PROCESS ENGINEERING TOOL IN POLLUTION PREVENTION

EPA Science Inventory

Computer-Aided Process Engineering has become established in industry as a design tool. With the establishment of the CAPE-OPEN software specifications for process simulation environments. CAPE-OPEN provides a set of "middleware" standards that enable software developers to acces...

Separating depressive comorbidity from panic disorder: A combined functional magnetic resonance imaging and machine learning approach.

PubMed

Lueken, Ulrike; Straube, Benjamin; Yang, Yunbo; Hahn, Tim; Beesdo-Baum, Katja; Wittchen, Hans-Ulrich; Konrad, Carsten; Ströhle, Andreas; Wittmann, André; Gerlach, Alexander L; Pfleiderer, Bettina; Arolt, Volker; Kircher, Tilo

2015-09-15

Depression is frequent in panic disorder (PD); yet, little is known about its influence on the neural substrates of PD. Difficulties in fear inhibition during safety signal processing have been reported as a pathophysiological feature of PD that is attenuated by depression. We investigated the impact of comorbid depression in PD with agoraphobia (AG) on the neural correlates of fear conditioning and the potential of machine learning to predict comorbidity status on the individual patient level based on neural characteristics. Fifty-nine PD/AG patients including 26 (44%) with a comorbid depressive disorder (PD/AG+DEP) underwent functional magnetic resonance imaging (fMRI). Comorbidity status was predicted using a random undersampling tree ensemble in a leave-one-out cross-validation framework. PD/AG-DEP patients showed altered neural activation during safety signal processing, while +DEP patients exhibited generally decreased dorsolateral prefrontal and insular activation. Comorbidity status was correctly predicted in 79% of patients (sensitivity: 73%; specificity: 85%) based on brain activation during fear conditioning (corrected for potential confounders: accuracy: 73%; sensitivity: 77%; specificity: 70%). No primary depressed patients were available; only medication-free patients were included. Major depression and dysthymia were collapsed (power considerations). Neurofunctional activation during safety signal processing differed between patients with or without comorbid depression, a finding which may explain heterogeneous results across previous studies. These findings demonstrate the relevance of comorbidity when investigating neurofunctional substrates of anxiety disorders. Predicting individual comorbidity status may translate neurofunctional data into clinically relevant information which might aid in planning individualized treatment. The study was registered with the ISRCTN80046034. Copyright © 2015 Elsevier B.V. All rights reserved.

The Division III Financial Aid Reporting Process: Findings and Review Results, 2005-06 through 2008-09

ERIC Educational Resources Information Center

National Collegiate Athletic Association (NJ1), 2009

2009-01-01

This report marks the completion of the 2008-09 reporting cycle and the fourth year of the Division III Financial Aid Reporting Program. The report examines findings for all reporting institutions from each of the four reporting cycles, and details the outcomes of the Division III Financial Aid Committee's 2008-09 review process. Four calculations…

When a Group Presentation Isn't Enough: Financial Aid Advising for Low-Income Urban College-Bound Students

ERIC Educational Resources Information Center

Venegas, Kristan M.; Hallett, Ronald E.

2008-01-01

Group presentations are an easy way to reach large groups of students and parents at one time. When group presentations are well done, they increase students' and families' knowledge of the financial aid process by providing information and building students' and their families' confidence as they navigate the financial aid process. Unfortunately,…

The theory, design, and operation of the suppressed carrier data-aided tracking receiver

NASA Technical Reports Server (NTRS)

Simon, M. K.; Springett, J. C.

1973-01-01

A viable, efficient, and easily mechanized carrier regenerating receiver for use in suppressed carrier-tracking system is described. The receiver referred to as a data-aided receiver (DAR) incorporates a data-aided loop (DAL) which provides the required carrier reference signal. The DAL employs the principle of decision feedback and as such is more efficient than other forms of suppressed carrier-tracking loops. The analysis, design, and implementation of the DAR are covered in detail. Performance comparisons and mechanization tradeoffs are made, wherever possible, with discrete carrier systems and other suppressed carrier systems presently in use. Experimental performance verification is given throughout in support of the theory presented.

Timbre Analysis of the Sonicguide

ERIC Educational Resources Information Center

Welch, James

1977-01-01

The timbre of various Sonicguide (an ultar-sonic binaural device mounted in a spectacle frame) signals was measured and analyzed by a "Sona-Graph" (sound spectral analyzer) to aid/mobility training of blind Ss. (Author/MH)

Left-right and front-back spatial hearing with multiple directional microphone configurations in modern hearing aids.

PubMed

Carette, Evelyne; Van den Bogaert, Tim; Laureyns, Mark; Wouters, Jan

2014-10-01

Several studies have demonstrated negative effects of directional microphone configurations on left-right and front-back (FB) sound localization. New processing schemes, such as frequency-dependent directionality and front focus with wireless ear-to-ear communication in recent, commercial hearing aids may preserve the binaural cues necessary for left-right localization and may introduce useful spectral cues necessary for FB disambiguation. In this study, two hearing aids with different processing schemes, which were both designed to preserve the ability to localize sounds in the horizontal plane (left-right and FB), were compared. We compared horizontal (left-right and FB) sound localization performance of hearing aid users fitted with two types of behind-the-ear (BTE) devices. The first type of BTE device had four different programs that provided (1) no directionality, (2-3) symmetric frequency-dependent directionality, and (4) an asymmetric configuration. The second pair of BTE devices was evaluated in its omnidirectional setting. This setting automatically activates a soft forward-oriented directional scheme that mimics the pinna effect. Also, wireless communication between the hearing aids was present in this configuration (5). A broadband stimulus was used as a target signal. The directional hearing abilities of the listeners were also evaluated without hearing aids as a reference. A total of 12 listeners with moderate to severe hearing loss participated in this study. All were experienced hearing-aid users. As a reference, 11 listeners with normal hearing participated. The participants were positioned in a 13-speaker array (left-right, -90°/+90°) or 7-speaker array (FB, 0-180°) and were asked to report the number of the loudspeaker located the closest to where the sound was perceived. The root mean square error was calculated for the left-right experiment, and the percentage of FB errors was used as a FB performance measure. RESULTS were analyzed with repeated-measures analysis of variance. For the left-right localization task, no significant differences could be proven between the unaided condition and both partial directional schemes and the omnidirectional scheme. The soft forward-oriented system and the asymmetric system did show a detrimental effect compared with the unaided condition. On average, localization was worst when users used the asymmetric condition. Analysis of the results of the FB experiment showed good performance, similar to unaided, with both the partial directional systems and the asymmetric configuration. Significantly worse performance was found with the omnidirectional and the omnidirectional soft forward-oriented BTE systems compared with the other hearing-aid systems. Bilaterally fitted partial directional systems preserve (part of) the binaural cues necessary for left-right localization and introduce, preserve, or enhance useful spectral cues that allow FB disambiguation. Omnidirectional systems, although good for left-right localization, do not provide the user with enough spectral information for an optimal FB localization performance. American Academy of Audiology.

Dual-microphone and binaural noise reduction techniques for improved speech intelligibility by hearing aid users

NASA Astrophysics Data System (ADS)

Yousefian Jazi, Nima

Spatial filtering and directional discrimination has been shown to be an effective pre-processing approach for noise reduction in microphone array systems. In dual-microphone hearing aids, fixed and adaptive beamforming techniques are the most common solutions for enhancing the desired speech and rejecting unwanted signals captured by the microphones. In fact, beamformers are widely utilized in systems where spatial properties of target source (usually in front of the listener) is assumed to be known. In this dissertation, some dual-microphone coherence-based speech enhancement techniques applicable to hearing aids are proposed. All proposed algorithms operate in the frequency domain and (like traditional beamforming techniques) are purely based on the spatial properties of the desired speech source and does not require any knowledge of noise statistics for calculating the noise reduction filter. This benefit gives our algorithms the ability to address adverse noise conditions, such as situations where interfering talker(s) speaks simultaneously with the target speaker. In such cases, the (adaptive) beamformers lose their effectiveness in suppressing interference, since the noise channel (reference) cannot be built and updated accordingly. This difference is the main advantage of the proposed techniques in the dissertation over traditional adaptive beamformers. Furthermore, since the suggested algorithms are independent of noise estimation, they offer significant improvement in scenarios that the power level of interfering sources are much more than that of target speech. The dissertation also shows the premise behind the proposed algorithms can be extended and employed to binaural hearing aids. The main purpose of the investigated techniques is to enhance the intelligibility level of speech, measured through subjective listening tests with normal hearing and cochlear implant listeners. However, the improvement in quality of the output speech achieved by the algorithms are also presented to show that the proposed methods can be potential candidates for future use in commercial hearing aids and cochlear implant devices.

EXTENSION OF COMPUTER-AIDED PROCESS ENGINEERING APPLICATIONS TO ENVIRONMENTAL LIFE CYCLE ASSESSMENT AND SUPPLY CHAIN MANAGEMENT

EPA Science Inventory

The potential of computer-aided process engineering (CAPE) tools to enable process engineers to improve the environmental performance of both their processes and across the life cycle (from cradle-to-grave) has long been proffered. However, this use of CAPE has not been fully ach...

Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis.

PubMed

Solanki, Hitendra S; Advani, Jayshree; Khan, Aafaque Ahmad; Radhakrishnan, Aneesha; Sahasrabuddhe, Nandini A; Pinto, Sneha M; Chang, Xiaofei; Prasad, Thottethodi Subrahmanya Keshava; Mathur, Premendu Prakash; Sidransky, David; Gowda, Harsha; Chatterjee, Aditi

2017-08-01

Proteomics analysis of chronic cigarette smoke exposure is a rapidly emerging postgenomics research field. While smoking is a major cause of lung cancer, functional studies using proteomics approaches could enrich our mechanistic understanding of the elusive lung cancer global molecular signaling and cigarette smoke relationship. We report in this study on a stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analysis of a human lung mucoepidermoid carcinoma cell line, H292 cells, chronically exposed to cigarette smoke. Using high resolution Orbitrap Velos mass spectrometer, we identified the hyperphosphorylation of 493 sites, which corresponds to 341 proteins and 195 hypophosphorylated sites, mapping to 142 proteins upon smoke exposure (2.0-fold change). We report differential phosphorylation of multiple kinases, including PAK6, EPHA4, LYN, mitogen-activated protein kinase, and phosphatases, including TMEM55B, PTPN14, TIGAR, among others, in response to chronic cigarette smoke exposure. Bioinformatics analysis revealed that the molecules differentially phosphorylated upon chronic exposure of cigarette smoke are associated with PI3K/AKT/mTOR and CDC42-PAK signaling pathways. These signaling networks are involved in multiple cellular processes, including cell polarity, cytoskeletal remodeling, cellular migration, protein synthesis, autophagy, and apoptosis. The present study contributes to emerging proteomics insights on cigarette smoke mediated global signaling in lung cells, which in turn may aid in development of precision medicine therapeutics and postgenomics biomarkers.

Speech reception with different bilateral directional processing schemes: Influence of binaural hearing, audiometric asymmetry, and acoustic scenario.

PubMed

Neher, Tobias; Wagener, Kirsten C; Latzel, Matthias

2017-09-01

Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds for frequencies below 2 kHz, a large spread in the binaural intelligibility level difference (BILD), and no difference in age, overall degree of hearing loss, or performance on a measure of selective attention took part. Aided speech reception was measured using virtual acoustics together with a simulation of a linked pair of completely occluding behind-the-ear HAs. Five processing schemes and three acoustic scenarios were used. The processing schemes differed in the tradeoff between signal-to-noise ratio (SNR) improvement and binaural cue preservation. The acoustic scenarios consisted of a frontal target talker presented against two speech maskers from ±60° azimuth or spatially diffuse cafeteria noise. For both groups, a significant interaction between BILD, processing scheme, and acoustic scenario was found. This interaction implied that, in situations with lateral speech maskers, HA users with BILDs larger than about 2 dB profited more from preserved low-frequency binaural cues than from greater SNR improvement, whereas for smaller BILDs the opposite was true. Audiometric asymmetry reduced the influence of binaural hearing. In spatially diffuse noise, the maximal SNR improvement was generally beneficial. N 0 S π detection performance at 500 Hz predicted the benefit from low-frequency binaural cues. Together, these findings provide a basis for adapting bilateral directional processing to individual and situational influences. Further research is needed to investigate their generalizability to more realistic HA conditions (e.g., with low-frequency vent-transmitted sound). Copyright © 2017 Elsevier B.V. All rights reserved.

Molecular Ultrasound Imaging for the Detection of Neural Inflammation

NASA Astrophysics Data System (ADS)

Volz, Kevin R.

Molecular imaging is a form of nanotechnology that enables the noninvasive examination of biological processes in vivo. Radiopharmaceutical agents are used to selectively target biochemical markers, which permits their detection and evaluation. Early visualization of molecular variations indicative of pathophysiological processes can aid in patient diagnoses and management decisions. Molecular imaging is performed by introducing molecular probes into the body. Molecular probes are often contrast agents that have been nanoengineered to selectively target and tether to molecules, enabling their radiologic identification. Ultrasound contrast agents have been demonstrated as an effective method of detecting perfusion at the tissue level. Through a nanoengineering process, ultrasound contrast agents can be targeted to specific molecules, thereby extending ultrasound's capabilities from the tissue to molecular level. Molecular ultrasound, or targeted contrast enhanced ultrasound (TCEUS), has recently emerged as a popular molecular imaging technique due to its ability to provide real-time anatomical and functional information in the absence of ionizing radiation. However, molecular ultrasound represents a novel form of molecular imaging, and consequently remains largely preclinical. A review of the TCEUS literature revealed multiple preclinical studies demonstrating its success in detecting inflammation in a variety of tissues. Although, a gap was identified in the existing evidence, as TCEUS effectiveness for detection of neural inflammation in the spinal cord was unable to be uncovered. This gap in knowledge, coupled with the profound impacts that this TCEUS application could have clinically, provided rationale for its exploration, and use as contributory evidence for the molecular ultrasound body of literature. An animal model that underwent a contusive spinal cord injury was used to establish preclinical evidence of TCEUS to detect neural inflammation. Imaging was performed while targeting three early inflammatory markers (P-selectin, VCAM-1, ICAM-1). Imaging protocols and outcome measures of previous TCEUS investigations of inflammation were replicated to aid in comparisons of outcomes. Signal intensity data was used to generate time intensity curves for qualitative and quantitative analysis of contrast agent temporal behavior. A proof of principle study established preclinical evidence to support the ability of TCEUS to detect acute neural inflammation. Substantial increases in signal intensities were observed while targeting inflammatory markers compared to controls. Further investigations consisted of examining molecular ultrasound sensitivity, and were accomplished by examining targeted contrast agent dosing parameters, and the ability of TCEUS to longitudinally evaluate neural inflammation. Qualitative analysis of TCEUS imaging performed with both administered doses revealed marked increases in signal intensities during acute inflammation, where inflammatory marker expression was presumably at its highest. This was in comparison to measures obtained in the absence of, and during, chronic inflammation. This research contributes much needed empirical evidence to the molecular ultrasound body of literature, and represents the first steps towards advancing this TCEUS application to clinical practice. Future studies are necessary to further these findings and effectively build upon this evidence. Increasing evidence of TCEUS use for the detection of neural inflammation will aid in its eventual clinical translation, where it will likely have a positive impact on patient care.

An Integrated Model of Application, Admission, Enrollment, and Financial Aid

ERIC Educational Resources Information Center

DesJardins, Stephen L.; Ahlburg, Dennis A.; McCall, Brian Patrick

2006-01-01

We jointly model the application, admission, financial aid determination, and enrollment decision process. We find that expectations of admission affect application probabilities, financial aid expectations affect enrollment and application behavior, and deviations from aid expectations are strongly related to enrollment. We also conduct…

UNG protects B cells from AID-induced telomere loss

PubMed Central

Cortizas, Elena M.; Zahn, Astrid; Safavi, Shiva

2016-01-01

Activation-induced deaminase (AID) initiates antibody gene diversification by creating G:U mismatches in the immunoglobulin loci. However, AID also deaminates nonimmunoglobulin genes, and failure to faithfully repair these off-target lesions can cause B cell lymphoma. In this study, we identify a mechanism by which processing of G:U produced by AID at the telomeres can eliminate B cells at risk of genomic instability. We show that telomeres are off-target substrates of AID and that B cell proliferation depends on protective repair by uracil-DNA glycosylase (UNG). In contrast, in the absence of UNG activity, deleterious processing by mismatch repair leads to telomere loss and defective cell proliferation. Indeed, we show that UNG deficiency reduces B cell clonal expansion in the germinal center in mice and blocks the proliferation of tumor B cells expressing AID. We propose that AID-induced damage at telomeres acts as a fail-safe mechanism to limit the tumor promoting activity of AID when it overwhelms uracil excision repair. PMID:27697833

Economic Comparison of Processes Using Spreadsheet Programs

NASA Technical Reports Server (NTRS)

Ferrall, J. F.; Pappano, A. W.; Jennings, C. N.

1986-01-01

Inexpensive approach aids plant-design decisions. Commercially available electronic spreadsheet programs aid economic comparison of different processes for producing particular end products. Facilitates plantdesign decisions without requiring large expenditures for powerful mainframe computers.

Improving the Financial Aid Process for Community College Students: A Literature Review of FAFSA Simplification, Information, and Verification

ERIC Educational Resources Information Center

Davidson, J. Cody

2015-01-01

Research has shown that community college and other low income students have the most need regarding the financial aid process. Community college students are less likely to complete the free application for federal student aid (FAFSA) than students at public and private four-year and for-profit institutions. Surveys have shown that the complexity…

Instructional Aides: Employment, Payroll Procedures, Supervision, Performance Appraisal, Legal Aspects.

ERIC Educational Resources Information Center

Nielsen, Earl T.

Designed to assist school administrators in their efforts to secure, train, and retain the most qualified instructional aides available, the monograph discusses procedures for employment, payroll processing, aide supervision, performance appraisal, and legal aspects involved in the hiring of instructional aides. Specific topics include…

DEVELOPMENT AND USE OF COMPUTER-AIDED PROCESS ENGINEERING TOOLS FOR POLLUTION PREVENTION

EPA Science Inventory

The use of Computer-Aided Process Engineering (CAPE) and process simulation tools has become established industry practice to predict simulation software, new opportunities are available for the creation of a wide range of ancillary tools that can be used from within multiple sim...

Facial expressions perceived by the adolescent brain: Towards the proficient use of low spatial frequency information.

PubMed

Peters, Judith C; Kemner, Chantal

2017-10-01

Rapid decoding of emotional expressions is essential for social communication. Fast processing of facial expressions depends on the adequate (subcortical) processing of important global face cues in the low spatial frequency (LSF) ranges. However, children below 9 years of age extract fearful expression information from local details represented by high SF (HSF) image content. Our ERP study investigated at which developmental stage this ineffective HSF-driven processing is replaced by the proficient and rapid LSF-driven perception of fearful faces, in which adults are highly skilled. We examined behavioral and neural responses to high- and low-pass filtered faces with a fearful or neutral expression in groups of children on the verge of pre-adolescence (9-10 years), adolescents (14-15 years), and young adults (20-28 years). Our results suggest that the neural emotional face processing network has a protracted maturational course into adolescence, which is related to changes in SF processing. In mid-adolescence, increased sensitivity to emotional LSF cues is developed, which aids the fast and adequate processing of fearful expressions that might signal impending danger. Copyright © 2017 Elsevier B.V. All rights reserved.

Benefits of adaptive FM systems on speech recognition in noise for listeners who use hearing aids.

PubMed

Thibodeau, Linda

2010-06-01

To compare the benefits of adaptive FM and fixed FM systems through measurement of speech recognition in noise with adults and students in clinical and real-world settings. Five adults and 5 students with moderate-to-severe hearing loss completed objective and subjective speech recognition in noise measures with the 2 types of FM processing. Sentence recognition was evaluated in a classroom for 5 competing noise levels ranging from 54 to 80 dBA while the FM microphone was positioned 6 in. from the signal loudspeaker to receive input at 84 dB SPL. The subjective measures included 2 classroom activities and 6 auditory lessons in a noisy, public aquarium. On the objective measures, adaptive FM processing resulted in significantly better speech recognition in noise than fixed FM processing for 68- and 73-dBA noise levels. On the subjective measures, all individuals preferred adaptive over fixed processing for half of the activities. Adaptive processing was also preferred by most (8-9) individuals for the remaining 4 activities. The adaptive FM processing resulted in significant improvements at the higher noise levels and was preferred by the majority of participants in most of the conditions.

75 FR 997 - Record of Decision (ROD) on the U.S. Coast Guard Long Range Aids to Navigation (Loran-C) Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... first developed during World War II and operated by the USCG. The current Loran-C system is a low... the Loran-C radionavigation signal by October 1, 2010. ADDRESSES: To view the ROD or the Final PEIS... the Loran-C radionavigation signal by October 1, 2010. The Final PEIS on the future of the USCG Loran...

Seafloor Geosciences Division. Missions, Technical Specialties, Accomplishments and Activities, Calendar Year 1984.

DTIC Science & Technology

1985-07-01

description of the sediment elastic properties for use in acoustic bottom interaction models . The compressional and shear wave velocity probe development was...SURVEYS POWER SOURCE INPUT TO MODELS : SIGNAL GENERATOR ACOUSTIC SIGNAL CONDITIONER GEOACOUSTIC TEMPERATURE MONITOR MINE BURIAL AID CONVERTOR ASW ARRAYS...F., J. Lipkin, and R. H. Bennett. Response of Marine Sediment to rapid Changes in Hydrostati TPessure Part I: Poroelastic Model Analysis. Geotechni

New forms of development: branding innovative ideas and bidding for foreign aid in the maternal and child health service in Nepal.

PubMed

Adhikari, Radha; Smith, Pam; Sharma, Jeevan Raj; Chand, Obindra Bahadur

2018-03-27

Nepal has been receiving foreign aid since the early 1950s. Currently, the country's health care system is heavily dependent on aid, even for the provision of basic health services to its people. Globally, the mechanism for the dispersal of foreign aid is becoming increasingly complex. Numerous stakeholders are involved at various levels: donors, intermediary organisations, project-implementing partners and the beneficiaries, engaging not only in Nepal but also globally. To illustrate how branding and bidding occurs, and to discuss how this process has become increasingly vital in securing foreign aid to run MCH activities in Nepal. This paper is based on a qualitative study. The data collection method includes Key Informant Interviews, the review of relevant policy documents and secondary data, and finally field observation visits to four maternal and child health (MCH) projects, currently funded by foreign aid. Through these methods we planned to gain a comprehensive understanding of the aid dispersing mechanism, and the aid-securing strategies, used by organisations seeking funds to provide MCH services in Nepal. Study findings suggest that foreign aid for the provision of MCH services in Nepal is channeled increasingly to its beneficiaries, not through the Government system, but rather via various intermediary organisations, employing branding and bidding processes. These organisations adapt commercial models, seeking to justify their 'cost-effectiveness'. They argue that they are 'yielding good value for money', with short-term target oriented projects. This ethos is evident throughout the aid dispersing chain. Organisations use innovative ideas and intervention packages, branded internationally and nationally, and employ the appropriate language of commerce in their bid to secure funds. The paper raises an important question as to whether the current mechanisms of channeling foreign aid in the MCH sector, via intermediary organisations, can actually be cost-effective, given the complex bureaucratic processes involved. The study findings are very important, for Nepal's development in particular, and for international development in general. The paper concludes by recommending strongly that foreign aid should concentrate on supporting and strengthening the national government system. Complex bureaucratic process must be minimised and streamlined in order to provide quality care to the beneficiaries.

The Use of Signal Dimensionality for Automatic QC of Seismic Array Data

NASA Astrophysics Data System (ADS)

Rowe, C. A.; Stead, R. J.; Begnaud, M. L.; Draganov, D.; Maceira, M.; Gomez, M.

2014-12-01

A significant problem in seismic array analysis is the inclusion of bad sensor channels in the beam-forming process. We are testing an approach to automated, on-the-fly quality control (QC) to aid in the identification of poorly performing sensor channels prior to beam-forming in routine event detection or location processing. The idea stems from methods used for large computer servers, when monitoring traffic at enormous numbers of nodes is impractical on a node-by-node basis, so the dimensionality of the node traffic is instead monitored for anomalies that could represent malware, cyber-attacks or other problems. The technique relies upon the use of subspace dimensionality or principal components of the overall system traffic. The subspace technique is not new to seismology, but its most common application has been limited to comparing waveforms to an a priori collection of templates for detecting highly similar events in a swarm or seismic cluster. We examine the signal dimension in similar way to the method addressing node traffic anomalies in large computer systems. We explore the effects of malfunctioning channels on the dimension of the data and its derivatives, and how to leverage this effect for identifying bad array elements. We show preliminary results applied to arrays in Kazakhstan (Makanchi) and Argentina (Malargue).

Metric traffic signal design manual

DOT National Transportation Integrated Search

2003-03-01

This manual is for information purposes only and may be used to aid new employees, and those unfamiliar with ODOT Traffic Engineering practices, in accessing and applying applicable standards, statutes, rules, and policies related to railroad preempt...

Integrated optimisation technique based on computer-aided capacity and safety evaluation for managing downstream lane-drop merging area of signalised junctions

NASA Astrophysics Data System (ADS)

Chen, CHAI; Yiik Diew, WONG

2017-02-01

This study provides an integrated strategy, encompassing microscopic simulation, safety assessment, and multi-attribute decision-making, to optimize traffic performance at downstream merging area of signalized intersections. A Fuzzy Cellular Automata (FCA) model is developed to replicate microscopic movement and merging behavior. Based on simulation experiment, the proposed FCA approach is able to provide capacity and safety evaluation of different traffic scenarios. The results are then evaluated through data envelopment analysis (DEA) and analytic hierarchy process (AHP). Optimized geometric layout and control strategies are then suggested for various traffic conditions. An optimal lane-drop distance that is dependent on traffic volume and speed limit can thus be established at the downstream merging area.

New method of noncontact temperature measurement in on-line textile production

NASA Astrophysics Data System (ADS)

Cheng, Xianping; Song, Xing-Li; Deng, Xing-Zhong

1993-09-01

Based on the condition of textile production the method of infrared non-contact temperature measurement is adcpted in the heat-setting and drying heat-treatment process . This method is used to monitor the moving cloth. The temperature of the cloth is displayed rapidly and exactly. The principle of the temperature measurement is analysed theoretically in this paper. Mathematical analysis and calculation are used for introducing signal transmitting method. Adopted method of combining software with hardware the temperature is corrected and compensated with the aid of a single-chip microcomputer. The results of test indicate that the application of temperature measurement instrument provides reliable parameters in the quality control. And it is an important measure on improving the quality of products.

Statistical analysis of RHIC beam position monitors performance

NASA Astrophysics Data System (ADS)

Calaga, R.; Tomás, R.

2004-04-01

A detailed statistical analysis of beam position monitors (BPM) performance at RHIC is a critical factor in improving regular operations and future runs. Robust identification of malfunctioning BPMs plays an important role in any orbit or turn-by-turn analysis. Singular value decomposition and Fourier transform methods, which have evolved as powerful numerical techniques in signal processing, will aid in such identification from BPM data. This is the first attempt at RHIC to use a large set of data to statistically enhance the capability of these two techniques and determine BPM performance. A comparison from run 2003 data shows striking agreement between the two methods and hence can be used to improve BPM functioning at RHIC and possibly other accelerators.

Messages of distinction: the HIV/AIDS media campaign in Thailand.

PubMed

Lyttleton, C

1996-03-01

In predominantly rural Thailand, television is a primary source of HIV/AIDS knowledge. Since 1990, HIV/AIDS warning messages have been aired regularly and repeatedly on television as part of the national strategy to minimize transmission of HIV. The education and prevention messages chosen do more than suggest measures to avoid infection. Within a logic of risk, these messages also define characteristics of people who are signified as threatening agents of infection. In Thailand, prostitutes and drug users are portrayed as the feared Other. Because commercial sex is so widespread, the demarcation of prostitutes as a high risk group signals a diffuse threat not easily subject to conceptual distancing. It is the pervasive and often fear-based associations born of the media material that, in large part, establish the basis for emergent practice when thoughts or actions are triggered by consideration of HIV/AIDS.

Adaptive gain and filtering circuit for a sound reproduction system

NASA Technical Reports Server (NTRS)

Engebretson, A. Maynard (Inventor); O'Connell, Michael P. (Inventor)

1998-01-01

Adaptive compressive gain and level dependent spectral shaping circuitry for a hearing aid include a microphone to produce an input signal and a plurality of channels connected to a common circuit output. Each channel has a preset frequency response. Each channel includes a filter with a preset frequency response to receive the input signal and to produce a filtered signal, a channel amplifier to amplify the filtered signal to produce a channel output signal, a threshold register to establish a channel threshold level, and a gain circuit. The gain circuit increases the gain of the channel amplifier when the channel output signal falls below the channel threshold level and decreases the gain of the channel amplifier when the channel output signal rises above the channel threshold level. A transducer produces sound in response to the signal passed by the common circuit output.

Lipid rafts generate digital-like signal transduction in cell plasma membranes.

PubMed

Suzuki, Kenichi G N

2012-06-01

Lipid rafts are meso-scale (5-200 nm) cell membrane domains where signaling molecules assemble and function. However, due to their dynamic nature, it has been difficult to unravel the mechanism of signal transduction in lipid rafts. Recent advanced imaging techniques have revealed that signaling molecules are frequently, but transiently, recruited to rafts with the aid of protein-protein, protein-lipid, and/or lipid-lipid interactions. Individual signaling molecules within the raft are activated only for a short period of time. Immobilization of signaling molecules by cytoskeletal actin filaments and scaffold proteins may facilitate more efficient signal transmission from rafts. In this review, current opinions of how the transient nature of molecular interactions in rafts generates digital-like signal transduction in cell membranes, and the benefits this phenomenon provides, are discussed. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Director of Financial Aid Handbook.

ERIC Educational Resources Information Center

Sorenson, Lynn D.

Although many independent schools are seeing a diversification in their student bodies, existing structures, such as financial aid awards, have not been modified. In addition, many financial-aid managers in independent schools have 0-5 years of experience in student financial aid. This handbook profiles the overall step-by-step process for…

Financial Aid for Students with Disabilities, 1999.

ERIC Educational Resources Information Center

American Council on Education, Washington, DC. HEATH Resource Center.

This resource paper provides an overview of student financial aid and discusses the roles and responsibilities of those who play a significant part in the process of providing aid to students with disabilities. The paper also addresses the financial aid application procedure and suggests timeliness and resources for those individuals who are…

Financial Aid for Students with Disabilities. 1993. [Update.

ERIC Educational Resources Information Center

Hartman, Rhona C.; Mazzeo, Kelly Kendrick

This resource paper on financial aid for postsecondary education covers various types of financial aid (grants, loans, and employment); the technical words and phrases used to discuss it (such as "financial need,""family contribution," and "financial aid package"); and the process involved in its disbursement. Particular attention is given to…

2011-2012 FSA Handbook with Active Index

ERIC Educational Resources Information Center

Federal Student Aid, US Department of Education, 2012

2012-01-01

This publication is intended for financial aid administrators and counselors who help students begin the aid process--filing the Free Application for Federal Student Aid (FAFSA), verifying information, and making corrections and other changes to the information reported on the FAFSA. The Federal Student Aid Handbook consists of the Application and…

EDExpress Application Processing, 1999-2000.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This document is a comprehensive guide to electronic data exchange (EDE) of Title IV student financial aid application data to and from the U.S. Department of Education. An overview chapter defines terms for processing financial aid applications through EDE, explains the seven-step process for sending and receiving data using EDE, and describes…

Methods of Estimating Strategic Intentions

DTIC Science & Technology

1982-05-01

34mental Images of future events" which might be brought to reality. To assess this step In the intention process the analyst may have to consler the...li. DESCRIPTION OF THE INTENTION EST!MATION PROCESS AND RELATED ANALYTICAL AIDS ........ ....... ................ A...OF AIDS AND PROCESS SUMMARY ............................... 115 v . BIBLIOGRAPHY ....................... .. . . . ............... . ...... 138 3on

The Effect of Adaptive Nonlinear Frequency Compression on Phoneme Perception.

PubMed

Glista, Danielle; Hawkins, Marianne; Bohnert, Andrea; Rehmann, Julia; Wolfe, Jace; Scollie, Susan

2017-12-12

This study implemented a fitting method, developed for use with frequency lowering hearing aids, across multiple testing sites, participants, and hearing aid conditions to evaluate speech perception with a novel type of frequency lowering. A total of 8 participants, including children and young adults, participated in real-world hearing aid trials. A blinded crossover design, including posttrial withdrawal testing, was used to assess aided phoneme perception. The hearing aid conditions included adaptive nonlinear frequency compression (NFC), static NFC, and conventional processing. Enabling either adaptive NFC or static NFC improved group-level detection and recognition results for some high-frequency phonemes, when compared with conventional processing. Mean results for the distinction component of the Phoneme Perception Test (Schmitt, Winkler, Boretzki, & Holube, 2016) were similar to those obtained with conventional processing. Findings suggest that both types of NFC tested in this study provided a similar amount of speech perception benefit, when compared with group-level performance with conventional hearing aid technology. Individual-level results are presented with discussion around patterns of results that differ from the group average.

Financing federal-aid highways

DOT National Transportation Integrated Search

1999-08-01

Because of a continuing demand for information concerning the financing of Federal-aid highways, the Federal Highway Administration (FHWA) prepared a report, "Financing Federal-Aid Highways," in January 1974 to describe the basic process involved. Th...

Modeling DNA structure and processes through animation and kinesthetic visualizations

NASA Astrophysics Data System (ADS)

Hager, Christine

There have been many studies regarding the effectiveness of visual aids that go beyond that of static illustrations. Many of these have been concentrated on the effectiveness of visual aids such as animations and models or even non-traditional visual aid activities like role-playing activities. This study focuses on the effectiveness of three different types of visual aids: models, animation, and a role-playing activity. Students used a modeling kit made of Styrofoam balls and toothpicks to construct nucleotides and then bond nucleotides together to form DNA. Next, students created their own animation to depict the processes of DNA replication, transcription, and translation. Finally, students worked in teams to build proteins while acting out the process of translation. Students were given a pre- and post-test that measured their knowledge and comprehension of the four topics mentioned above. Results show that there was a significant gain in the post-test scores when compared to the pre-test scores. This indicates that the incorporated visual aids were effective methods for teaching DNA structure and processes.

Computer-aided design development transition for IPAD environment

NASA Technical Reports Server (NTRS)

Owens, H. G.; Mock, W. D.; Mitchell, J. C.

1980-01-01

The relationship of federally sponsored computer-aided design/computer-aided manufacturing (CAD/CAM) programs to the aircraft life cycle design process, an overview of NAAD'S CAD development program, an evaluation of the CAD design process, a discussion of the current computing environment within which NAAD is developing its CAD system, some of the advantages/disadvantages of the NAAD-IPAD approach, and CAD developments during transition into the IPAD system are discussed.

Real-time loudness normalisation with combined cochlear implant and hearing aid stimulation

PubMed Central

Van Eeckhoutte, Maaike; Van Deun, Lieselot; Francart, Tom

2018-01-01

Background People who use a cochlear implant together with a contralateral hearing aid—so-called bimodal listeners—have poor localisation abilities and sounds are often not balanced in loudness across ears. In order to address the latter, a loudness balancing algorithm was created, which equalises the loudness growth functions for the two ears. The algorithm uses loudness models in order to continuously adjust the two signals to loudness targets. Previous tests demonstrated improved binaural balance, improved localisation, and better speech intelligibility in quiet for soft phonemes. In those studies, however, all stimuli were preprocessed so spontaneous head movements and individual head-related transfer functions were not taken into account. Furthermore, the hearing aid processing was linear. Study design In the present study, we simplified the acoustical loudness model and implemented the algorithm in a real-time system. We tested bimodal listeners on speech perception and on sound localisation, both in normal loudness growth configuration and in a configuration with a modified loudness growth function. We also used linear and compressive hearing aids. Results The comparison between the original acoustical loudness model and the new simplified model showed loudness differences below 3% for almost all tested speech-like stimuli and levels. We found no effect of balancing the loudness growth across ears for speech perception ability in quiet and in noise. We found some small improvements in localisation performance. Further investigation with a larger sample size is required. PMID:29617421

Primary or secondary tasks? Dual-task interference between cyclist hazard perception and cadence control using cross-modal sensory aids with rider assistance bike computers.

PubMed

Yang, Chao-Yang; Wu, Cheng-Tse

2017-03-01

This research investigated the risks involved in bicycle riding while using various sensory modalities to deliver training information. To understand the risks associated with using bike computers, this study evaluated hazard perception performance through lab-based simulations of authentic riding conditions. Analysing hazard sensitivity (d') of signal detection theory, the rider's response time, and eye glances provided insights into the risks of using bike computers. In this study, 30 participants were tested with eight hazard perception tasks while they maintained a cadence of 60 ± 5 RPM and used bike computers with different sensory displays, namely visual, auditory, and tactile feedback signals. The results indicated that synchronously using different sense organs to receive cadence feedback significantly affects hazard perception performance; direct visual information leads to the worst rider distraction, with a mean sensitivity to hazards (d') of -1.03. For systems with multiple interacting sensory aids, auditory aids were found to result in the greatest reduction in sensitivity to hazards (d' mean = -0.57), whereas tactile sensory aids reduced the degree of rider distraction (d' mean = -0.23). Our work complements existing work in this domain by advancing the understanding of how to design devices that deliver information subtly, thereby preventing disruption of a rider's perception of road hazards. Copyright © 2016 Elsevier Ltd. All rights reserved.

75 FR 55798 - North American Bioproducts Corporation; Filing of Food Additive Petition (Animal Use); Penicillin...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... antimicrobial processing aid in fuel- ethanol fermentations with respect to its consequent presence in by... antimicrobial processing aid in fuel- ethanol fermentations with respect to its consequent presence in by...

Conservation and aid: designing more effective investments in natural resource governance reform.

PubMed

Nelson, Fred

2009-10-01

Biodiversity conservation outcomes are closely related to the rules and institutions governing resource use. Creating local incentives for conservation through more secure resource tenure is central to conservation outcomes on private and communal lands, where the preponderance of biodiversity occurs. Conservation efforts in sub-Saharan Africa are therefore centrally concerned with governance dynamics and institutional reform processes, such as the decentralization of property rights, and how best to achieve such reforms. Traditional mechanisms for financing conservation efforts in Africa rely heavily on funds channeled through multilateral and bilateral aid agencies. The history of development aid highlights a range of constraints these aid agencies face in terms of working toward more effective resource governance arrangements and promoting reforms. Government aid agencies possess incentives for promoting large-scale and short-term projects that maximize expenditure volumes and tend to define issues in technical rather than political terms. The history of development aid suggests that these and other characteristics of aid agencies impedes their ability to influence governance reform processes and that aid funding may discourage the adoption of reforms. Greater emphasis in African conservation financing needs to be placed on flexible, small-scale investments aligned to local interests and constituencies that prioritize innovation, learning, and experimentation. Additionally, more research is required that explores the linkages between conservation funding, donor decision-making processes, and governance reforms.

Acceptable noise level (ANL) with Danish and non-semantic speech materials in adult hearing-aid users.

PubMed

Olsen, Steen Østergaard; Lantz, Johannes; Nielsen, Lars Holme; Brännström, K Jonas

2012-09-01

The acceptable noise level (ANL) test is used for quantification of the amount of background noise subjects accept when listening to speech. This study investigates Danish hearing-aid users' ANL performance using Danish and non-semantic speech signals, the repeatability of ANL, and the association between ANL and outcome of the international outcome inventory for hearing aids (IOI-HA). ANL was measured in three conditions in both ears at two test sessions. Subjects completed the IOI-HA and the ANL questionnaire. Sixty-three Danish hearing-aid users; fifty-seven subjects were full time users and 6 were part time/non users of hearing aids according to the ANL questionnaire. ANLs were similar to results with American English speech material. The coefficient of repeatability (CR) was 6.5-8.8 dB. IOI-HA scores were not associated to ANL. Danish and non-semantic ANL versions yield results similar to the American English version. The magnitude of the CR indicates that ANL with Danish and non-semantic speech materials is not suitable for prediction of individual patterns of future hearing-aid use or evaluation of individual benefit from hearing-aid features. The ANL with Danish and non-semantic speech materials is not related to IOI-HA outcome.

Modeling and Development of INS-Aided PLLs in a GNSS/INS Deeply-Coupled Hardware Prototype for Dynamic Applications

PubMed Central

Zhang, Tisheng; Niu, Xiaoji; Ban, Yalong; Zhang, Hongping; Shi, Chuang; Liu, Jingnan

2015-01-01

A GNSS/INS deeply-coupled system can improve the satellite signals tracking performance by INS aiding tracking loops under dynamics. However, there was no literature available on the complete modeling of the INS branch in the INS-aided tracking loop, which caused the lack of a theoretical tool to guide the selections of inertial sensors, parameter optimization and quantitative analysis of INS-aided PLLs. This paper makes an effort on the INS branch in modeling and parameter optimization of phase-locked loops (PLLs) based on the scalar-based GNSS/INS deeply-coupled system. It establishes the transfer function between all known error sources and the PLL tracking error, which can be used to quantitatively evaluate the candidate inertial measurement unit (IMU) affecting the carrier phase tracking error. Based on that, a steady-state error model is proposed to design INS-aided PLLs and to analyze their tracking performance. Based on the modeling and error analysis, an integrated deeply-coupled hardware prototype is developed, with the optimization of the aiding information. Finally, the performance of the INS-aided PLLs designed based on the proposed steady-state error model is evaluated through the simulation and road tests of the hardware prototype. PMID:25569751

The evidence base for the application of contralateral bone anchored hearing aids in acquired unilateral sensorineural hearing loss in adults.

PubMed

Baguley, D M; Bird, J; Humphriss, R L; Prevost, A T

2006-02-01

. Acquired unilateral sensorineural hearing loss reduces the ability to localize sounds and to discriminate in background noise. . Four controlled trials attempt to determine the benefit of contralateral bone anchored hearing aids over contralateral routing of signal (CROS) hearing aids and over the unaided condition. All found no significant improvement in auditory localization with either aid. Speech discrimination in noise and subjective questionnaire measures of auditory abilities showed an advantage for bone anchored hearing aid (BAHA) > CROS > unaided conditions. . All four studies have material shortfalls: (i) the BAHA was always trialled after the CROS aid; (ii) CROS aids were only trialled for 4 weeks; (iii) none used any measure of hearing handicap when selecting subjects; (iv) two studies have a bias in terms of patient selection; (v) all studies were underpowered (vi) double reporting of patients occurred. . There is a paucity of evidence to support the efficacy of BAHA in the treatment of acquired unilateral sensorineural hearing loss. Clinicians should proceed with caution and perhaps await a larger randomized trial. . It is perhaps only appropriate to insert a BAHA peg at the time of vestibular schwanoma tumour excision in patients with good preoperative hearing, as their hearing handicap increases most.

Financing Federal-Aid Highways. August 1999 Edition

DOT National Transportation Integrated Search

1999-08-01

Because of a continuing demand for information concerning the financing of Federal-aid highways, the Federal Highway Administration (FHWA) prepared a report, "Financing Federal-Aid Highways," in January 1974 to describe the basic process involved. Th...

Synthesis and characterization of grinding aid fly ash blended mortar effect on bond strength of masonry prisms

NASA Astrophysics Data System (ADS)

Krishnaraj, L.; Ravichandran, P. T.; Sagadevan, Suresh

2018-04-01

The aim of the present work is to study the effect of particle size reduction by applying top-down nanotechnology such as ball mill grinding process with the addition of amine-based grinding aids. The particle size reduction in synthesis process and its characterization were investigated for fly ash particles. The Rosin-Rammler-Bennet (RRB) distribution model using mathematical formulations were studied for fly ash ground particles. The hardened properties of grinding aid fly ash composite mortar were studied using compressive strength test. The optimum grinding time was 120 min identified through the particle size distribution analysis. The mean particle size decreased from 92.09 μm to 10.5 μm in which there is 89% reduction in particle size due to the grinding of fly ash particle with grinding aids. The compressive strength results show that substitutions of Ordinary Portland Cement (OPC) mortar by Amine-based Grinding aid Fly Ash (AGFA) 15% gives 12, 23% and at 30% gives 6, 8% of higher strength compare to the substitutions of raw fly ash. The addition of grinding aids in grinding process gives more advantages to reduce the particle size without changing chemical composition. The AGFA sample shows better performance in compressive strength and bond strength behavior of masonry prism. It may suggest that amine based grinding aids play a vital role and feasible to use in fly ash grinding process.

Clarifying values: an updated review

PubMed Central

2013-01-01

Background Consensus guidelines have recommended that decision aids include a process for helping patients clarify their values. We sought to examine the theoretical and empirical evidence related to the use of values clarification methods in patient decision aids. Methods Building on the International Patient Decision Aid Standards (IPDAS) Collaboration’s 2005 review of values clarification methods in decision aids, we convened a multi-disciplinary expert group to examine key definitions, decision-making process theories, and empirical evidence about the effects of values clarification methods in decision aids. To summarize the current state of theory and evidence about the role of values clarification methods in decision aids, we undertook a process of evidence review and summary. Results Values clarification methods (VCMs) are best defined as methods to help patients think about the desirability of options or attributes of options within a specific decision context, in order to identify which option he/she prefers. Several decision making process theories were identified that can inform the design of values clarification methods, but no single “best” practice for how such methods should be constructed was determined. Our evidence review found that existing VCMs were used for a variety of different decisions, rarely referenced underlying theory for their design, but generally were well described in regard to their development process. Listing the pros and cons of a decision was the most common method used. The 13 trials that compared decision support with or without VCMs reached mixed results: some found that VCMs improved some decision-making processes, while others found no effect. Conclusions Values clarification methods may improve decision-making processes and potentially more distal outcomes. However, the small number of evaluations of VCMs and, where evaluations exist, the heterogeneity in outcome measures makes it difficult to determine their overall effectiveness or the specific characteristics that increase effectiveness. PMID:24625261

Modulation format identification aided hitless flexible coherent transceiver.

PubMed

Xiang, Meng; Zhuge, Qunbi; Qiu, Meng; Zhou, Xingyu; Zhang, Fangyuan; Tang, Ming; Liu, Deming; Fu, Songnian; Plant, David V

2016-07-11

We propose a hitless flexible coherent transceiver enabled by a novel modulation format identification (MFI) scheme for dynamic agile optical networks. The modulation format transparent digital signal processing (DSP) is realized by a block-wise decision-directed least-mean-square (DD-LMS) equalizer for channel tracking, and a pilot symbol aided superscalar phase locked loop (PLL) for carrier phase estimation (CPE). For the MFI, the modulation format information is encoded onto the pilot symbols initially used for CPE. Therefore, the proposed MFI method does not require extra overhead. Moreover, it can identify arbitrary modulation formats including multi-dimensional formats, and it enables tracking of the format change for short data blocks. The performance of the proposed hitless flexible coherent transceiver is successfully evaluated with five modulation formats including QPSK, 16QAM, 64QAM, Hybrid QPSK/8QAM and set-partitioning (SP)-512-QAM. We show that the proposed MFI method induces a negligible performance penalty. Moreover, we experimentally demonstrate that such a hitless transceiver can adapt to fast block-by-block modulation format switching. Finally, the performance improvement of the proposed MFI method is experimentally verified with respect to other commonly used MFI methods.

Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases

PubMed Central

Choi, Won-Tak; An, Jing

2014-01-01

Chemokines and their receptors are implicated in a wide range of human diseases, including acquired immune deficiency syndrome (AIDS). The entry of human immunodeficiency virus type 1 (HIV-1) into a cell is initiated by the interaction of the virus’s surface envelope proteins with two cell surface components of the target cell, namely CD4 and a chemokine co-receptor, usually CXCR4 or CCR5. Typical anti-HIV-1 agents include protease and reverse transcriptase inhibitors, but the targets of these agents tend to show rapid mutation rates. As such, strategies based on HIV-1 co-receptors have appeal because they target invariant host determinants. Chemokines and their receptors are also of general interest since they play important roles in numerous physiological and pathological processes in addition to AIDS. Therefore, intensive basic and translational research is ongoing for the dissection of their structure – function relationships in an effort to understand the molecular mechanism of chemokine – receptor interactions and signal transductions across cellular membranes. This paper reviews and discusses recent advances and the translation of new knowledge and discoveries into novel interventional strategies for clinical application. PMID:21565895

The cybernetic rehabilitation aid: preliminary results for wrist and elbow motions in healthy subjects.

PubMed

Akdogan, Erhan; Shima, Keisuke; Kataoka, Hitoshi; Hasegawa, Masaki; Otsuka, Akira; Tsuji, Toshio

2012-09-01

This paper proposes the cybernetic rehabilitation aid (CRA) based on the concept of direct teaching using tactile feedback with electromyography (EMG)-based motor skill evaluation. Evaluation and teaching of motor skills are two important aspects of rehabilitation training, and the CRA provides novel and effective solutions to potentially solve the difficulties inherent in these two processes within a single system. In order to evaluate motor skills, EMG signals measured from a patient are analyzed using a log-linearized Gaussian mixture network that can classify motion patterns and compute the degree of similarity between the patient's measured EMG patterns and the desired pattern provided by the therapist. Tactile stimulators are used to convey motion instructions from the therapist or the system to the patient, and a rehabilitation robot can also be integrated into the developed prototype to increase its rehabilitation capacity. A series of experiments performed using the developed prototype demonstrated that the CRA can work as a human-human, human-computer and human-machine system. The experimental results indicated that the healthy (able-bodied) subjects were able to follow the desired muscular contraction levels instructed by the therapist or the system and perform proper joint motion without relying on visual feedback.

Hopes & Hurdles: California Foster Youth and College Financial Aid

ERIC Educational Resources Information Center

Cochrane, Deborah Frankle; Szabo-Kubitz, Laura

2009-01-01

This report examines why former foster youth in California are not receiving the aid they are likely eligible for, from inadequate or poorly targeted information about college costs and financial aid to structural obstacles within the aid process and programs. While many of this report's findings and recommendations are specific to foster youth,…

State of Student Aid and Higher Education in Texas

ERIC Educational Resources Information Center

Creusere, Marlena; Fletcher, Carla; Klepfer, Kasey; Norman, Patricia

2015-01-01

TG provides critical support to schools, students, and borrowers at every stage of the federal student aid process--from providing information on how to pay for a higher education including financial aid options, to facilitating successful loan repayment after graduation. This issue of "State of Student Aid and Higher Education in Texas"…

Federal Student Aid Handbook, 2006-2007. Application and Verification Guide

ERIC Educational Resources Information Center

US Department of Education, 2006

2006-01-01

This publication is intended for financial aid administrators and counselors who help students begin the student aid process--filing the Free Application for Federal Student Aid (FAFSA), verifying information, and making corrections and other changes to the information reported on the FAFSA. This guide contains the following chapters: (1) The…

Performance benefits of adaptive, multimicrophone, interference-canceling systems in everyday environments

NASA Astrophysics Data System (ADS)

Desloge, Joseph G.; Zimmer, Martin J.; Zurek, Patrick M.

2004-05-01

Adaptive multimicrophone systems are currently used for a variety of noise-cancellation applications (such as hearing aids) to preserve signals arriving from a particular (target) direction while canceling other (jammer) signals in the environment. Although the performance of these systems is known to degrade with increasing reverberation, there are few measurements of adaptive performance in everyday reverberant environments. In this study, adaptive performance was compared to that of a simple, nonadaptive cardioid microphone to determine a measure of adaptive benefit. Both systems used recordings (at an Fs of 22050 Hz) from the same two omnidirectional microphones, which were separated by 1 cm. Four classes of environment were considered: outdoors, household, parking garage, and public establishment. Sources were either environmental noises (e.g., household appliances, restaurant noise) or a controlled noise source. In all situations, no target was present (i.e., all signals were jammers) to obtain maximal jammer cancellation. Adaptive processing was based upon the Griffiths-Jim generalized sidelobe canceller using filter lengths up to 400 points. Average intelligibility-weighted adaptive benefit levels at a source distance of 1 m were, at most, 1.5 dB for public establishments, 2 dB for household rooms and the parking garage, and 3 dB outdoors. [Work supported by NIOSH.

An integrated tool for the diagnosis of voice disorders.

PubMed

Godino-Llorente, Juan I; Sáenz-Lechón, Nicolás; Osma-Ruiz, Víctor; Aguilera-Navarro, Santiago; Gómez-Vilda, Pedro

2006-04-01

A PC-based integrated aid tool has been developed for the analysis and screening of pathological voices. With it the user can simultaneously record speech, electroglottographic (EGG), and videoendoscopic signals, and synchronously edit them to select the most significant segments. These multimedia data are stored on a relational database, together with a patient's personal information, anamnesis, diagnosis, visits, explorations and any other comment the specialist may wish to include. The speech and EGG waveforms are analysed by means of temporal representations and the quantitative measurements of parameters such as spectrograms, frequency and amplitude perturbation measurements, harmonic energy, noise, etc. are calculated using digital signal processing techniques, giving an idea of the degree of hoarseness and quality of the voice register. Within this framework, the system uses a standard protocol to evaluate and build complete databases of voice disorders. The target users of this system are speech and language therapists and ear nose and throat (ENT) clinicians. The application can be easily configured to cover the needs of both groups of professionals. The software has a user-friendly Windows style interface. The PC should be equipped with standard sound and video capture cards. Signals are captured using common transducers: a microphone, an electroglottograph and a fiberscope or telelaryngoscope. The clinical usefulness of the system is addressed in a comprehensive evaluation section.

Cardiac phase detection in intravascular ultrasound images

NASA Astrophysics Data System (ADS)

Matsumoto, Monica M. S.; Lemos, Pedro Alves; Yoneyama, Takashi; Furuie, Sergio Shiguemi

2008-03-01

Image gating is related to image modalities that involve quasi-periodic moving organs. Therefore, during intravascular ultrasound (IVUS) examination, there is cardiac movement interference. In this paper, we aim to obtain IVUS gated images based on the images themselves. This would allow the reconstruction of 3D coronaries with temporal accuracy for any cardiac phase, which is an advantage over the ECG-gated acquisition that shows a single one. It is also important for retrospective studies, as in existing IVUS databases there are no additional reference signals (ECG). From the images, we calculated signals based on average intensity (AI), and, from consecutive frames, average intensity difference (AID), cross-correlation coefficient (CC) and mutual information (MI). The process includes a wavelet-based filter step and ascendant zero-cross detection in order to obtain the phase information. Firstly, we tested 90 simulated sequences with 1025 frames each. Our method was able to achieve more than 95.0% of true positives and less than 2.3% of false positives ratio, for all signals. Afterwards, we tested in a real examination, with 897 frames and ECG as gold-standard. We achieved 97.4% of true positives (CC and MI), and 2.5% of false positives. For future works, methodology should be tested in wider range of IVUS examinations.

Using LDPC Code Constraints to Aid Recovery of Symbol Timing

NASA Technical Reports Server (NTRS)

Jones, Christopher; Villasnor, John; Lee, Dong-U; Vales, Esteban

2008-01-01

A method of utilizing information available in the constraints imposed by a low-density parity-check (LDPC) code has been proposed as a means of aiding the recovery of symbol timing in the reception of a binary-phase-shift-keying (BPSK) signal representing such a code in the presence of noise, timing error, and/or Doppler shift between the transmitter and the receiver. This method and the receiver architecture in which it would be implemented belong to a class of timing-recovery methods and corresponding receiver architectures characterized as pilotless in that they do not require transmission and reception of pilot signals. Acquisition and tracking of a signal of the type described above have traditionally been performed upstream of, and independently of, decoding and have typically involved utilization of a phase-locked loop (PLL). However, the LDPC decoding process, which is iterative, provides information that can be fed back to the timing-recovery receiver circuits to improve performance significantly over that attainable in the absence of such feedback. Prior methods of coupling LDPC decoding with timing recovery had focused on the use of output code words produced as the iterations progress. In contrast, in the present method, one exploits the information available from the metrics computed for the constraint nodes of an LDPC code during the decoding process. In addition, the method involves the use of a waveform model that captures, better than do the waveform models of the prior methods, distortions introduced by receiver timing errors and transmitter/ receiver motions. An LDPC code is commonly represented by use of a bipartite graph containing two sets of nodes. In the graph corresponding to an (n,k) code, the n variable nodes correspond to the code word symbols and the n-k constraint nodes represent the constraints that the code places on the variable nodes in order for them to form a valid code word. The decoding procedure involves iterative computation of values associated with these nodes. A constraint node represents a parity-check equation using a set of variable nodes as inputs. A valid decoded code word is obtained if all parity-check equations are satisfied. After each iteration, the metrics associated with each constraint node can be evaluated to determine the status of the associated parity check. Heretofore, normally, these metrics would be utilized only within the LDPC decoding process to assess whether or not variable nodes had converged to a codeword. In the present method, it is recognized that these metrics can be used to determine accuracy of the timing estimates used in acquiring the sampled data that constitute the input to the LDPC decoder. In fact, the number of constraints that are satisfied exhibits a peak near the optimal timing estimate. Coarse timing estimation (or first-stage estimation as described below) is found via a parametric search for this peak. The present method calls for a two-stage receiver architecture illustrated in the figure. The first stage would correct large time delays and frequency offsets; the second stage would track random walks and correct residual time and frequency offsets. In the first stage, constraint-node feedback from the LDPC decoder would be employed in a search algorithm in which the searches would be performed in successively narrower windows to find the correct time delay and/or frequency offset. The second stage would include a conventional first-order PLL with a decision-aided timing-error detector that would utilize, as its decision aid, decoded symbols from the LDPC decoder. The method has been tested by means of computational simulations in cases involving various timing and frequency errors. The results of the simulations ined in the ideal case of perfect timing in the receiver.

Ultrasensitive sensing platform for platelet-derived growth factor BB detection based on layered molybdenum selenide-graphene composites and Exonuclease III assisted signal amplification.

PubMed

Huang, Ke-Jing; Shuai, Hong-Lei; Zhang, Ji-Zong

2016-03-15

A highly sensitive and ultrasensitive electrochemical aptasensor for platelet-derived growth factor BB (PDGF-BB) detection is fabricated based on layered molybdenum selenide-graphene (MoSe2-Gr) composites and Exonuclease III (Exo III)-aided signal amplification. MoSe2-Gr is prepared by a simple hydrothermal method and used as a promising sensing platform. Exo III has a specifical exo-deoxyribonuclease activity for duplex DNAs in the direction from 3' to 5' terminus, however its activity is limited on the duplex DNAs with more than 4 mismatched terminal bases at 3' ends. Herein, aptamer and complementary DNA (cDNA) sequences are designed with four thymine bases on 3' ends. In the presence of target protein, the aptamer associates with it and facilitates the formation of duplex DNA between cDNA and signal DNA. The duplex DNA then is digested by Exo III and releases cDNA, which hybridizes with signal DNA to perform a new cleavage process. Nevertheless, in the absence of target protein, the aptamer hybridizes with cDNA will inhibit the Exo III-assisted nucleotides cleavage. The signal DNA then hybridizes with capture DNA on the electrode. Subsequently, horse radish peroxidase is fixed on electrode by avidin-biotin reaction and then catalyzes hydrogen peroxide and hydroquinone to produce electrochemical response. Therefore, a bridge can be established between the concentration of target protein and the degree of the attenuation of the obtained signal, providing a quantitative measure of target protein with a broad detection range of 0.0001-1 nM and a detection limit of 20 fM. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluating Water Storage Variations in the MENA region using GRACE Satellite Data

NASA Astrophysics Data System (ADS)

Lopez, O.; Houborg, R.; McCabe, M. F.

2013-12-01

Terrestrial water storage (TWS) variations over large river basins can be derived from temporal gravity field variations observed by the Gravity Recovery and Climate Experiment (GRACE) satellites. These signals are useful for determining accurate estimates of water storage and fluxes over areas covering a minimum of 150,000 km2 (length scales of a few hundred kilometers) and thus prove to be a valuable tool for regional water resources management, particularly for areas with a lack of in-situ data availability or inconsistent monitoring, such as the Middle East and North Africa (MENA) region. This already stressed arid region is particularly vulnerable to climate change and overdraft of its non-renewable freshwater sources, and thus direction in managing its resources is a valuable aid. An inter-comparison of different GRACE-derived TWS products was done in order to provide a quantitative assessment on their uncertainty and their utility for diagnosing spatio-temporal variability in water storage over the MENA region. Different processing approaches for the inter-satellite tracking data from the GRACE mission have resulted in the development of TWS products, with resolutions in time from 10 days to 1 month and in space from 0.5 to 1 degree global gridded data, while some of them use input from land surface models in order to restore the original signal amplitudes. These processing differences and the difficulties in recovering the mass change signals over arid regions will be addressed. Output from the different products will be evaluated and compared over basins inside the MENA region, and compared to output from land surface models.

Predictors of Hearing-Aid Outcomes

PubMed Central

Johannesen, Peter T.; Pérez-González, Patricia; Blanco, José L.; Kalluri, Sridhar; Edwards, Brent

2017-01-01

Over 360 million people worldwide suffer from disabling hearing loss. Most of them can be treated with hearing aids. Unfortunately, performance with hearing aids and the benefit obtained from using them vary widely across users. Here, we investigate the reasons for such variability. Sixty-eight hearing-aid users or candidates were fitted bilaterally with nonlinear hearing aids using standard procedures. Treatment outcome was assessed by measuring aided speech intelligibility in a time-reversed two-talker background and self-reported improvement in hearing ability. Statistical predictive models of these outcomes were obtained using linear combinations of 19 predictors, including demographic and audiological data, indicators of cochlear mechanical dysfunction and auditory temporal processing skills, hearing-aid settings, working memory capacity, and pretreatment self-perceived hearing ability. Aided intelligibility tended to be better for younger hearing-aid users with good unaided intelligibility in quiet and with good temporal processing abilities. Intelligibility tended to improve by increasing amplification for low-intensity sounds and by using more linear amplification for high-intensity sounds. Self-reported improvement in hearing ability was hard to predict but tended to be smaller for users with better working memory capacity. Indicators of cochlear mechanical dysfunction, alone or in combination with hearing settings, did not affect outcome predictions. The results may be useful for improving hearing aids and setting patients’ expectations. PMID:28929903

A novel scheme to aid coherent detection of GMSK signals in fast Rayleigh fading channels

NASA Technical Reports Server (NTRS)

Leung, Patrick S. K.; Feher, Kamilo

1990-01-01

A novel scheme to insert carrier pilot to Gaussian Minimum Shift Keying (GMSK) signal using Binary Block Code (BBC) and a highpass filter in baseband is proposed. This allows the signal to be coherently demodulated even in a fast Rayleigh fading environment. As an illustrative example, the scheme is applied to a 16 kb/s GMSK signal, and its performance over a fast Rayleigh fading channel is investigated using computer simulation. This modem's 'irreducible error rate' is found to be Pe = 5.5 x 10(exp -5) which is more than that of differential detection. The modem's performance in Rician fading channel is currently under investigation.

The Influence of decision aids on prostate cancer screening preferences: A randomized survey study.

PubMed

Weiner, Adam B; Tsai, Kyle P; Keeter, Mary-Kate; Victorson, David E; Schaeffer, Edward M; Catalona, William J; Kundu, Shilajit D

2018-05-28

Shared decision making is recommended regarding prostate cancer screening. Decision aids may facilitate this process; however, the impact of decision aids on screening preferences is poorly understood. In an online survey, a national sample of adults were randomized to one of six different professional societies' online decision aids. We compared pre- and post-decision aid responses. The primary outcome was change in participant likelihood to undergo or recommend prostate cancer screening on a scale of 1 (unlikely) to 100 (extremely likely). Secondary outcomes included change in participant comfort with prostate cancer screening based on the average of six, five-point Likert-scale questions. Median age was 53 years for the 1,336 participants, and 50% were men. Randomized groups did not differ significantly by race, age, gender, income, marital status, or education level. Likelihood to undergo or recommend prostate cancer screening decreased from 83 to 78 following decision aid exposure (p<0.001; Figure). Reviewing the decision aid from the Centers for Disease Control or American Academy of Family Physicians did not alter likelihood (both p>0.2), while the decision aid from the United States Preventive Services Task Force was associated with the largest decrease in screening preference (-16.0, p<0.001). Participants reported increased comfort with the decision-making process for prostate cancer screening from 3.5 to 4.1 (out of 5, p<0.001) following exposure to a decision aid. Exposure to a decision aid decreased participant likelihood to undergo or recommend prostate cancer screening and increased comfort with the screening process. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Converging roles for sphingolipids and cell stress in the progression of neurological dysfunction in AIDS

PubMed Central

Haughey, Norman J.; Steiner, Joesph; Nath, Avindra; McArthur, Justin; Sacktor, Ned; Pardo, Carlos; Bandaru, Veera Venkata Ratnam

2009-01-01

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling. PMID:18508574

The application of data mining and cloud computing techniques in data-driven models for structural health monitoring

NASA Astrophysics Data System (ADS)

Khazaeli, S.; Ravandi, A. G.; Banerji, S.; Bagchi, A.

2016-04-01

Recently, data-driven models for Structural Health Monitoring (SHM) have been of great interest among many researchers. In data-driven models, the sensed data are processed to determine the structural performance and evaluate the damages of an instrumented structure without necessitating the mathematical modeling of the structure. A framework of data-driven models for online assessment of the condition of a structure has been developed here. The developed framework is intended for automated evaluation of the monitoring data and structural performance by the Internet technology and resources. The main challenges in developing such framework include: (a) utilizing the sensor measurements to estimate and localize the induced damage in a structure by means of signal processing and data mining techniques, and (b) optimizing the computing and storage resources with the aid of cloud services. The main focus in this paper is to demonstrate the efficiency of the proposed framework for real-time damage detection of a multi-story shear-building structure in two damage scenarios (change in mass and stiffness) in various locations. Several features are extracted from the sensed data by signal processing techniques and statistical methods. Machine learning algorithms are deployed to select damage-sensitive features as well as classifying the data to trace the anomaly in the response of the structure. Here, the cloud computing resources from Amazon Web Services (AWS) have been used to implement the proposed framework.

Segmentation-based L-filtering of speckle noise in ultrasonic images

NASA Astrophysics Data System (ADS)

Kofidis, Eleftherios; Theodoridis, Sergios; Kotropoulos, Constantine L.; Pitas, Ioannis

1994-05-01

We introduce segmentation-based L-filters, that is, filtering processes combining segmentation and (nonadaptive) optimum L-filtering, and use them for the suppression of speckle noise in ultrasonic (US) images. With the aid of a suitable modification of the learning vector quantizer self-organizing neural network, the image is segmented in regions of approximately homogeneous first-order statistics. For each such region a minimum mean-squared error L- filter is designed on the basis of a multiplicative noise model by using the histogram of grey values as an estimate of the parent distribution of the noisy observations and a suitable estimate of the original signal in the corresponding region. Thus, we obtain a bank of L-filters that are corresponding to and are operating on different image regions. Simulation results on a simulated US B-mode image of a tissue mimicking phantom are presented which verify the superiority of the proposed method as compared to a number of conventional filtering strategies in terms of a suitably defined signal-to-noise ratio measure and detection theoretic performance measures.

Biomedical Instruments for Fetal and Neonatal Surveillance

NASA Astrophysics Data System (ADS)

Rolfe, P.; Scopesi, F.; Serra, G.

2006-10-01

Specialised instruments have been developed to aid the care of the fetus and the newborn baby. Miniature sensors using optical, electrical, chemical, mechanical and magnetic principles have been produced for capturing key measurands. These include temperature, pressure, flow and dimension, as well as several specific molecules such as glucose, oxygen and carbon dioxide. During pregnancy ultrasound imaging and blood flow techniques provide valuable information concerning fetal abnormalities, fetal growth, fetal breathing and fetal heart rate. Signal processing and pattern recognition can be useful for deriving indicators of fetal distress and clinical status, based on biopotentials as well as ultrasound signals. Fetal pH measurement is a critical requirement during labour and delivery. The intensive care of ill preterm babies involves provision of an optimal thermal environment and respiratory support. Monitoring of blood gas and acid-base status is essential, and this involves both blood sampling for in vitro analysis as well as the use of invasive or non-invasive sensors. For the future it will be vital that the technologies used are subjected to controlled trials to establish benefit or otherwise.

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms.

PubMed

Gürsoy, Ulvi K; Gürsoy, Mervi; Könönen, Eija; Sintim, Herman O

2017-01-01

Oral cavity acts as a reservoir of bacterial pathogens for systemic infections and several oral microorganisms have been linked to systemic diseases. Quorum sensing and cyclic dinucleotides, two "decision-making" signaling systems, communicate to regulate physiological process in bacteria. Discovery of cyclic dinucleotides has a long history, but the progress in our understanding of how cyclic dinucleotides regulate bacterial lifestyle is relatively new. Oral microorganisms form some of the most intricate biofilms, yet c-di-GMP, and c-di-AMP signaling have been rarely studied in oral biofilms. Recent studies demonstrated that, with the aid of bacterial messenger molecules and their analogs, it is possible to activate host innate and adaptive immune responses and epithelial integrity with a dose that is relevant to inhibit bacterial virulence mechanisms, such as fimbriae and exopolysaccharide production, biofilm formation, and host cell invasion. The aim of this perspective article is to present available information on cyclic dinucleotides in oral bacteria and in oral biofilms. Moreover, technologies that can be used to detect cyclic dinucleotides in oral biofilms are described. Finally, directions for future research are highlighted.

ECG Sensor Card with Evolving RBP Algorithms for Human Verification.

PubMed

Tseng, Kuo-Kun; Huang, Huang-Nan; Zeng, Fufu; Tu, Shu-Yi

2015-08-21

It is known that cardiac and respiratory rhythms in electrocardiograms (ECGs) are highly nonlinear and non-stationary. As a result, most traditional time-domain algorithms are inadequate for characterizing the complex dynamics of the ECG. This paper proposes a new ECG sensor card and a statistical-based ECG algorithm, with the aid of a reduced binary pattern (RBP), with the aim of achieving faster ECG human identity recognition with high accuracy. The proposed algorithm has one advantage that previous ECG algorithms lack-the waveform complex information and de-noising preprocessing can be bypassed; therefore, it is more suitable for non-stationary ECG signals. Experimental results tested on two public ECG databases (MIT-BIH) from MIT University confirm that the proposed scheme is feasible with excellent accuracy, low complexity, and speedy processing. To be more specific, the advanced RBP algorithm achieves high accuracy in human identity recognition and is executed at least nine times faster than previous algorithms. Moreover, based on the test results from a long-term ECG database, the evolving RBP algorithm also demonstrates superior capability in handling long-term and non-stationary ECG signals.

33 CFR 67.25-10 - Sound signal.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES Class âBâ Requirements § 67.25-10 Sound... a shoal area that it is not a hazard to navigation. [CGD 72-74R, 37 FR 13513, July 8, 1972, as...

33 CFR 67.25-10 - Sound signal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES Class âBâ Requirements § 67.25-10 Sound... a shoal area that it is not a hazard to navigation. [CGD 72-74R, 37 FR 13513, July 8, 1972, as...

Translating Evidence to Facilitate Shared Decision Making: Development and Usability of a Consult Decision Aid Prototype.

PubMed

Stacey, Dawn; Légaré, France; Lyddiatt, Anne; Giguere, Anik M C; Yoganathan, Manosila; Saarimaki, Anton; Pardo, Jordi Pardo; Rader, Tamara; Tugwell, Peter

2016-12-01

The purpose of this study was to translate evidence from Cochrane Reviews into a format that can be used to facilitate shared decision making during the consultation, namely patient decision aids. A systematic development process (a) established a stakeholder committee; (b) developed a prototype according to the International Patient Decision Aid Standards; (c) applied the prototype to a Cochrane Review and used an interview-guided survey to evaluate acceptability/usability; (d) created 12 consult decision aids; and (e) used a Delphi process to reach consensus on considerations for creating a consult decision aid. The 1-page prototype includes (a) a title specifying the decision; (b) information on the health condition, options, benefits/harms with probabilities; (c) an explicit values clarification exercise; and (d) questions to screen for decisional conflict. Hyperlinks provide additional information on definitions, probabilities presented graphically, and references. Fourteen Cochrane Consumer Network members and Cochrane Editorial Unit staff participated. Thirteen reported that it would help patient/clinician discussions and were willing to use and/or recommend it. Seven indicated the right amount of information, six not enough, and one too much. Changes to the prototype were more links to definitions, more white space, and details on GRADE evidence ratings. Creating 12 consult decision aids took about 4 h each. We identified ten considerations when selecting Cochrane Reviews for creating consult decision aids. Using a systematic process, we developed a consult decision aid prototype to be populated with evidence from Cochrane Reviews. It was acceptable and easy to apply. Future studies will evaluate implementation of consult decision aids.

Country watch: Malawi.

PubMed

Knox, G

1995-01-01

The Drought Network for information sharing eventually led to the establishment of the more formal Southern Region AIDS Network (SORAN) where representatives from government and nongovernmental organizations (NGOs) focused on awareness raising, lobbying, and advocacy. As an initial step towards networking on HIV/AIDS issues, a festival was organized in Blantyre on December 4, 1993, by NGOs, private companies, church groups, school children, and volunteers to bring about behavior change. About 2000 people gathered to listen to music, learn about HIV transmission through drama group presentations, watch videos with HIV/STD prevention messages, and learn about proper condom use. The participants officially established SORAN in February 1994 to act as a coordinating body for organizations working in prevention and care for HIV/STD-infected persons and their families. Network activities endeavored: to assist organizations interested in developing HIV/AIDS programs and activities; to encourage the business communities to participate in multisectoral coordination and to help channel funds from them to HIV/AIDS programs; to act as a resource center for information about HIV/AIDS; and to lobby among politicians as well as traditional local and religious leaders. When the first multi-party parliamentary election approached in May 1994, SORAN challenged representatives of 7 political parties and a women's organization to speak out publicly on what they envisioned doing about HIV/AIDS. The Grand Walk was also organized by SORAN members representing the Catholic Episcopal Conference of Malawi, the Protestant Blantyre Synod, a local brewery, and UNICEF. About 500 walkers received support from passersby. 70% were school children 10-18 years old who sang AIDS awareness songs and passed out flyers. Three months later the National AIDS Program's Big Walk for AIDS, following a National AIDS Crisis Conference, signaled the government's public recognition of the need for a multisectoral approach to combatting HIV/AIDS.

Factors associated with the use of cognitive aids in operating room crises: a cross-sectional study of US hospitals and ambulatory surgical centers.

PubMed

Alidina, Shehnaz; Goldhaber-Fiebert, Sara N; Hannenberg, Alexander A; Hepner, David L; Singer, Sara J; Neville, Bridget A; Sachetta, James R; Lipsitz, Stuart R; Berry, William R

2018-03-26

Operating room (OR) crises are high-acuity events requiring rapid, coordinated management. Medical judgment and decision-making can be compromised in stressful situations, and clinicians may not experience a crisis for many years. A cognitive aid (e.g., checklist) for the most common types of crises in the OR may improve management during unexpected and rare events. While implementation strategies for innovations such as cognitive aids for routine use are becoming better understood, cognitive aids that are rarely used are not yet well understood. We examined organizational context and implementation process factors influencing the use of cognitive aids for OR crises. We conducted a cross-sectional study using a Web-based survey of individuals who had downloaded OR cognitive aids from the websites of Ariadne Labs or Stanford University between January 2013 and January 2016. In this paper, we report on the experience of 368 respondents from US hospitals and ambulatory surgical centers. We analyzed the relationship of more successful implementation (measured as reported regular cognitive aid use during applicable clinical events) with organizational context and with participation in a multi-step implementation process. We used multivariable logistic regression to identify significant predictors of reported, regular OR cognitive aid use during OR crises. In the multivariable logistic regression, small facility size was associated with a fourfold increase in the odds of a facility reporting more successful implementation (p = 0.0092). Completing more implementation steps was also significantly associated with more successful implementation; each implementation step completed was associated with just over 50% higher odds of more successful implementation (p ≤ 0.0001). More successful implementation was associated with leadership support (p < 0.0001) and dedicated time to train staff (p = 0.0189). Less successful implementation was associated with resistance among clinical providers to using cognitive aids (p < 0.0001), absence of an implementation champion (p = 0.0126), and unsatisfactory content or design of the cognitive aid (p = 0.0112). Successful implementation of cognitive aids in ORs was associated with a supportive organizational context and following a multi-step implementation process. Building strong organizational support and following a well-planned multi-step implementation process will likely increase the use of OR cognitive aids during intraoperative crises, which may improve patient outcomes.

Determination of preferred parameters for multichannel compression using individually fitted simulated hearing AIDS and paired comparisons.

PubMed

Moore, Brian C J; Füllgrabe, Christian; Stone, Michael A

2011-01-01

To determine preferred parameters of multichannel compression using individually fitted simulated hearing aids and a method of paired comparisons. Fourteen participants with mild to moderate hearing loss listened via a simulated five-channel compression hearing aid fitted using the CAMEQ2-HF method to pairs of speech sounds (a male talker and a female talker) and musical sounds (a percussion instrument, orchestral classical music, and a jazz trio) presented sequentially and indicated which sound of the pair was preferred and by how much. The sounds in each pair were derived from the same token and differed along a single dimension in the type of processing applied. For the speech sounds, participants judged either pleasantness or clarity; in the latter case, the speech was presented in noise at a 2-dB signal-to-noise ratio. For musical sounds, they judged pleasantness. The parameters explored were time delay of the audio signal relative to the gain control signal (the alignment delay), compression speed (attack and release times), bandwidth (5, 7.5, or 10 kHz), and gain at high frequencies relative to that prescribed by CAMEQ2-HF. Pleasantness increased with increasing alignment delay only for the percussive musical sound. Clarity was not affected by alignment delay. There was a trend for pleasantness to decrease slightly with increasing bandwidth, but this was significant only for female speech with fast compression. Judged clarity was significantly higher for the 7.5- and 10-kHz bandwidths than for the 5-kHz bandwidth for both slow and fast compression and for both talker genders. Compression speed had little effect on pleasantness for 50- or 65-dB SPL input levels, but slow compression was generally judged as slightly more pleasant than fast compression for an 80-dB SPL input level. Clarity was higher for slow than for fast compression for input levels of 80 and 65 dB SPL but not for a level of 50 dB SPL. Preferences for pleasantness were approximately equal with CAMEQ2-HF gains and with gains slightly reduced at high frequencies and were lower when gains were slightly increased at high frequencies. Speech clarity was not affected by changing the gain at high frequencies. Effects of alignment delay were small except for the percussive sound. A wider bandwidth was slightly preferred for speech clarity. Speech clarity was slightly greater with slow compression, especially at high levels. Preferred high-frequency gains were close to or a little below those prescribed by CAMEQ2-HF.

Perspective: next generation isotope-aided methods for protein NMR spectroscopy.

PubMed

Kainosho, Masatsune; Miyanoiri, Yohei; Terauchi, Tsutomu; Takeda, Mitsuhiro

2018-06-22

In this perspective, we describe our efforts to innovate the current isotope-aided NMR methodology to investigate biologically important large proteins and protein complexes, for which only limited structural information could be obtained by conventional NMR approaches. At the present time, it is widely believed that only backbone amide and methyl signals are amenable for investigating such difficult targets. Therefore, our primary mission is to disseminate our novel knowledge within the biological NMR community; specifically, that any type of NMR signals other than methyl and amide groups can be obtained, even for quite large proteins, by optimizing the transverse relaxation properties by isotope labeling methods. The idea of "TROSY by isotope labeling" has been cultivated through our endeavors aiming to improve the original stereo-array isotope labeling (SAIL) method (Kainosho et al., Nature 440:52-57, 2006). The SAIL TROSY methods subsequently culminated in the successful observations of individual NMR signals for the side-chain aliphatic and aromatic 13 CH groups in large proteins, as exemplified by the 82 kDa single domain protein, malate synthase G. Meanwhile, the expected role of NMR spectroscopy in the emerging integrative structural biology has been rapidly shifting, from structure determination to the acquisition of biologically relevant structural dynamics, which are poorly accessible by X-ray crystallography or cryo-electron microscopy. Therefore, the newly accessible NMR probes, in addition to the methyl and amide signals, will open up a new horizon for investigating difficult protein targets, such as membrane proteins and supramolecular complexes, by NMR spectroscopy. We briefly introduce our latest results, showing that the protons attached to 12 C-atoms give profoundly narrow 1 H-NMR signals even for large proteins, by isolating them from the other protons using the selective deuteration. The direct 1 H observation methods exhibit the highest sensitivities, as compared to heteronuclear multidimensional spectroscopy, in which the 1 H-signals are acquired via the spin-coupled 13 C- and/or 15 N-nuclei. Although the selective deuteration method was launched a half century ago, as the first milestone in the following prosperous history of isotope-aided NMR methods, our results strongly imply that the low-dimensional 1 H-direct observation NMR methods should be revitalized in the coming era, featuring ultrahigh-field spectrometers beyond 1 GHz.

A proposal for the development of national certification standards for patient decision aids in the US.

PubMed

Elwyn, Glyn; Burstin, Helen; Barry, Michael J; Corry, Maureen P; Durand, Marie Anne; Lessler, Daniel; Saigal, Christopher

2018-04-27

Efforts to implement the use of patient decision aids to stimulate shared decision making are gaining prominence. Patient decision aids have been designed to help patients participate in making specific choices among health care options. Because these tools clearly influence decisions, poor quality, inaccurate or unbalanced presentations or misleading tools are a risk to patients. As payer interest in these tools increases, so does the risk that patients are harmed by the use of tools that are described as patient decision aids yet fail to meet established standards. To address this problem, the National Quality Forum (NQF) in the USA convened a multi-stakeholder expert panel in 2016 to propose national standards for a patient decision aid certification process. In 2017, NQF established an Action Team to foster shared decision making, and to call for a national certification process as one recommendation among others to stimulate improvement. A persistent barrier to the setup of a national patient decision aids certification process is the lack of a sustainable financial model to support the work. Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

Grief-Processing-Based Psychological Intervention for Children Orphaned by AIDS in Central China: A Pilot Study

ERIC Educational Resources Information Center

Lin, Xiuyun; Fang, Xiaoyi; Chi, Peilian; Li, Xiaoming; Chen, Wenrui; Heath, Melissa Allen

2014-01-01

A group of 124 children orphaned by AIDS (COA), who resided in two orphanages funded by the Chinese government, participated in a study investigating the efficacy of a grief-processing-based psychological group intervention. This psychological intervention program was designed to specifically help COA process their grief and reduce their…

Conceptualization of Approaches and Thought Processes Emerging in Validating of Model in Mathematical Modeling in Technology Aided Environment

ERIC Educational Resources Information Center

Hidiroglu, Çaglar Naci; Bukova Güzel, Esra

2013-01-01

The aim of the present study is to conceptualize the approaches displayed for validation of model and thought processes provided in mathematical modeling process performed in technology-aided learning environment. The participants of this grounded theory study were nineteen secondary school mathematics student teachers. The data gathered from the…

Decision aids for randomised controlled trials: a qualitative exploration of stakeholders’ views

PubMed Central

Gillies, Katie; Skea, Zoë C; Campbell, Marion K

2014-01-01

Objectives To explore stakeholders’ perceptions of decision aids designed to support the informed consent decision-making process for randomised controlled trials. Design Qualitative semistructured interviews. Participants were provided with prototype trial decision aids in advance to stimulate discussion. Interviews were analysed using an established interpretive approach. Participants 23 stakeholders: Trial Managers (n=5); Research Nurses (n=5); Ethics Committee Chairs (n=5); patients (n=4) and Clinical Principal Investigators (n=4). Setting Embedded within two ongoing randomised controlled trials. All interviews conducted with UK-based participants. Results Certain key aspects (eg, values clarification exercises, presentation of probabilities, experiences of others and balance of options) in the prototype decision aids were perceived by all stakeholders as having a significant advantage (over existing patient information leaflets) in terms of supporting well informed appropriate decisions. However, there were some important differences between the stakeholder groups on specific content (eg, language used in the section on positive and negative features of taking part in a trial and the overall length of the trial decision aids). Generally the stakeholders believed trial decision aids have the potential to better engage potential participants in the decision-making process and allow them to make more personally relevant decisions about their participation. Conclusions Compared to existing patient information leaflets, stakeholders perceived decision aids for trial participation to have the potential to promote a more ‘informed’ decision-making process. Further efforts to develop, refine and formally evaluate trial decision aids should be explored. PMID:25138811

An Augmented Reality Endoscope System for Ureter Position Detection.

PubMed

Yu, Feng; Song, Enmin; Liu, Hong; Li, Yunlong; Zhu, Jun; Hung, Chih-Cheng

2018-06-25

Iatrogenic injury of ureter in the clinical operation may cause the serious complication and kidney damage. To avoid such a medical accident, it is necessary to provide the ureter position information to the doctor. For the detection of ureter position, an ureter position detection and display system with the augmented ris proposed to detect the ureter that is covered by human tissue. There are two key issues which should be considered in this new system. One is how to detect the covered ureter that cannot be captured by the electronic endoscope and the other is how to display the ureter position that provides stable and high-quality images. Simultaneously, any delayed processing of the system should disturb the surgery. The aided hardware detection method and target detection algorithms are proposed in this system. To mark the ureter position, a surface-lighting plastic optical fiber (POF) with the encoded light-emitting diode (LED) light is used to indicate the ureter position. The monochrome channel filtering algorithm (MCFA) is proposed to locate the ureter region more precisely. The ureter position is extracted using the proposed automatic region growing algorithm (ARGA) that utilizes the statistical information of the monochrome channel for the selection of growing seed point. In addition, according to the pulse signal of encoded light, the recognition of bright and dark frames based on the aided hardware (BDAH) is proposed to expedite the processing speed. Experimental results demonstrate that the proposed endoscope system can identify 92.04% ureter region in average.

A computer-aided telescope pointing system utilizing a video star tracker

NASA Technical Reports Server (NTRS)

Murphy, J. P.; Lorell, K. R.; Swift, C. D.

1975-01-01

The Video Inertial Pointing (VIP) System developed to satisfy the acquisition and pointing requirements of astronomical telescopes is described. A unique feature of the system is the use of a single sensor to provide information for the generation of three axis pointing error signals and for a cathode ray tube (CRT) display of the star field. The pointing error signals are used to update the telescope's gyro stabilization and the CRT display is used by an operator to facilitate target acquisition and to aid in manual positioning of the telescope optical axis. A model of the system using a low light level vidicon built and flown on a balloon-borne infrared telescope is briefly described from a state of the art charge coupled device (CCD) sensor. The advanced system hardware is described and an analysis of the multi-star tracking and three axis error signal generation, along with an analysis and design of the gyro update filter, are presented. Results of a hybrid simulation are described in which the advanced VIP system hardware is driven by a digital simulation of the star field/CCD sensor and an analog simulation of the telescope and gyro stabilization dynamics.

The AAF in the Invasion of Southern France

DTIC Science & Technology

1992-01-01

action. (e) To transport and drop airborne troops engaged in the operation. (f) To cooperate with the Maquis by air action and air supply. In addition MAAF...operations in aid of the Partisans. PLANNING As far back as i April 1943 the eyes of the Allied forces in the Mediterranean were focusing on a possible landing...elimination of bush and dry vegetation fire hazards; and erection of airfield buildings. Signals The problems faced by the Signals Planning Staff at

Managing fear in public health campaigns: a theory-based formative evaluation process.

PubMed

Cho, Hyunyi; Witte, Kim

2005-10-01

The HIV/AIDS infection rate of Ethiopia is one of the world's highest. Prevention campaigns should systematically incorporate and respond to at-risk population's existing beliefs, emotions, and perceived barriers in the message design process to effectively promote behavior change. However, guidelines for conducting formative evaluation that are grounded in proven risk communication theory and empirical data analysis techniques are hard to find. This article provides a five-step formative evaluation process that translates theory and research for developing effective messages for behavior change. Guided by the extended parallel process model, the five-step process helps message designers manage public's fear surrounding issues such as HIV/AIDS. An entertainment education project that used the process to design HIV/AIDS prevention messages for Ethiopian urban youth is reported. Data were collected in five urban regions of Ethiopia and analyzed according to the process to develop key messages for a 26-week radio soap opera.

Application of computer-aided diagnosis (CAD) in MR-mammography (MRM): do we really need whole lesion time curve distribution analysis?

PubMed

Baltzer, Pascal Andreas Thomas; Renz, Diane M; Kullnig, Petra E; Gajda, Mieczyslaw; Camara, Oumar; Kaiser, Werner A

2009-04-01

The identification of the most suspect enhancing part of a lesion is regarded as a major diagnostic criterion in dynamic magnetic resonance mammography. Computer-aided diagnosis (CAD) software allows the semi-automatic analysis of the kinetic characteristics of complete enhancing lesions, providing additional information about lesion vasculature. The diagnostic value of this information has not yet been quantified. Consecutive patients from routine diagnostic studies (1.5 T, 0.1 mmol gadopentetate dimeglumine, dynamic gradient-echo sequences at 1-minute intervals) were analyzed prospectively using CAD. Dynamic sequences were processed and reduced to a parametric map. Curve types were classified by initial signal increase (not significant, intermediate, and strong) and the delayed time course of signal intensity (continuous, plateau, and washout). Lesion enhancement was measured using CAD. The most suspect curve, the curve-type distribution percentage, and combined dynamic data were compared. Statistical analysis included logistic regression analysis and receiver-operating characteristic analysis. Fifty-one patients with 46 malignant and 44 benign lesions were enrolled. On receiver-operating characteristic analysis, the most suspect curve showed diagnostic accuracy of 76.7 +/- 5%. In comparison, the curve-type distribution percentage demonstrated accuracy of 80.2 +/- 4.9%. Combined dynamic data had the highest diagnostic accuracy (84.3 +/- 4.2%). These differences did not achieve statistical significance. With appropriate cutoff values, sensitivity and specificity, respectively, were found to be 80.4% and 72.7% for the most suspect curve, 76.1% and 83.6% for the curve-type distribution percentage, and 78.3% and 84.5% for both parameters. The integration of whole-lesion dynamic data tends to improve specificity. However, no statistical significance backs up this finding.

Neural decoding of attentional selection in multi-speaker environments without access to clean sources

NASA Astrophysics Data System (ADS)

O'Sullivan, James; Chen, Zhuo; Herrero, Jose; McKhann, Guy M.; Sheth, Sameer A.; Mehta, Ashesh D.; Mesgarani, Nima

2017-10-01

Objective. People who suffer from hearing impairments can find it difficult to follow a conversation in a multi-speaker environment. Current hearing aids can suppress background noise; however, there is little that can be done to help a user attend to a single conversation amongst many without knowing which speaker the user is attending to. Cognitively controlled hearing aids that use auditory attention decoding (AAD) methods are the next step in offering help. Translating the successes in AAD research to real-world applications poses a number of challenges, including the lack of access to the clean sound sources in the environment with which to compare with the neural signals. We propose a novel framework that combines single-channel speech separation algorithms with AAD. Approach. We present an end-to-end system that (1) receives a single audio channel containing a mixture of speakers that is heard by a listener along with the listener’s neural signals, (2) automatically separates the individual speakers in the mixture, (3) determines the attended speaker, and (4) amplifies the attended speaker’s voice to assist the listener. Main results. Using invasive electrophysiology recordings, we identified the regions of the auditory cortex that contribute to AAD. Given appropriate electrode locations, our system is able to decode the attention of subjects and amplify the attended speaker using only the mixed audio. Our quality assessment of the modified audio demonstrates a significant improvement in both subjective and objective speech quality measures. Significance. Our novel framework for AAD bridges the gap between the most recent advancements in speech processing technologies and speech prosthesis research and moves us closer to the development of cognitively controlled hearable devices for the hearing impaired.

Multilevel Analysis in Analyzing Speech Data

ERIC Educational Resources Information Center

Guddattu, Vasudeva; Krishna, Y.

2011-01-01

The speech produced by human vocal tract is a complex acoustic signal, with diverse applications in phonetics, speech synthesis, automatic speech recognition, speaker identification, communication aids, speech pathology, speech perception, machine translation, hearing research, rehabilitation and assessment of communication disorders and many…

Ultrasound transducer positioning aid for fetal heart rate monitoring.

PubMed

Hamelmann, Paul; Kolen, Alex; Schmitt, Lars; Vullings, Rik; van Assen, Hans; Mischi, Massimo; Demi, Libertario; van Laar, Judith; Bergmans, Jan

2016-08-01

Fetal heart rate (fHR) monitoring is usually performed by Doppler ultrasound (US) techniques. For reliable fHR measurements it is required that the fetal heart is located within the US beam. In clinical practice, clinicians palpate the maternal abdomen to identify the fetal presentation and then the US transducer is fixated on the maternal abdomen where the best fHR signal can be obtained. Finding the optimal transducer position is done by listening to the strength of the Doppler audio output and relying on a signal quality indicator of the cardiotocographic (CTG) measurement system. Due to displacement of the US transducer or displacement of the fetal heart out of the US beam, the fHR signal may be lost. Therefore, it is often necessary that the obstetrician repeats the tedious procedure of US transducer positioning to avoid long periods of fHR signal loss. An intuitive US transducer positioning aid would be highly desirable to increase the work flow for the clinical staff. In this paper, the possibility to determine the fetal heart location with respect to the transducer by exploiting the received signal power in the transducer elements is shown. A commercially available US transducer used for fHR monitoring is connected to an US open platform, which allows individual driving of the elements and raw US data acquisition. Based on the power of the received Doppler signals in the transducer elements, the fetal heart location can be estimated. A beating fetal heart setup was designed and realized for validation. The experimental results show the feasibility of estimating the fetal heart location with the proposed method. This can be used to support clinicians in finding the optimal transducer position for fHR monitoring more easily.

[Decision Making and Electrodermal Activity].

PubMed

Kobayakawa, Mutsutaka

2016-08-01

Decision making is aided by emotions. Bodily responses, such as sweating, heartbeat, and visceral sensation, are used to monitor the emotional state during decision making. Because decision making in dairy life is complicated and cognitively demanding, these bodily signals are thought to facilitate the decision making process by assigning positive or negative values for each of the behavioral options. The sweat response in a decision making task is measured by skin conductance response (SCR). SCR in decision making is divided into two categories: anticipatory SCR is observed before making decisions, and reward/punishment SCR is observed after the outcome of the decision is perceived. Brain lesion studies in human revealed that the amygdala and ventromedial prefrontal cortex are important in decision making. Patients with lesinon in the amygdala exhibit neither the anticipatory nor reward/punishment SCRs, while patients with the ventromedial prefrontal lesions have deficits only in the anticipatory SCRs. Decision making tasks and SCR analysis have contributed to reveal the implicit aspects of decision making. Further research is necessary for clarifying the role of explicit process of decision making and its relationship with the implicit process.

Transcriptomic Analysis Provides Insights into Grafting Union Development in Pecan (Carya illinoinensis).

PubMed

Mo, Zhenghai; Feng, Gang; Su, Wenchuan; Liu, Zhuangzhuang; Peng, Fangren

2018-02-05

Pecan ( Carya illinoinensis ), as a popular nut tree, has been widely planted in China in recent years. Grafting is an important technique for its cultivation. For a successful grafting, graft union development generally involves the formation of callus and vascular bundles at the graft union. To explore the molecular mechanism of graft union development, we applied high throughput RNA sequencing to investigate the transcriptomic profiles of graft union at four timepoints (0 days, 8 days, 15 days, and 30 days) during the pecan grafting process. After de novo assembly, 83,693 unigenes were obtained, and 40,069 of them were annotated. A total of 12,180 differentially expressed genes were identified between by grafting. Genes involved in hormone signaling, cell proliferation, xylem differentiation, cell elongation, secondary cell wall deposition, programmed cell death, and reactive oxygen species (ROS) scavenging showed significant differential expression during the graft union developmental process. In addition, we found that the content of auxin, cytokinin, and gibberellin were accumulated at the graft unions during the grafting process. These results will aid in our understanding of successful grafting in the future.

Transcriptomic Analysis Provides Insights into Grafting Union Development in Pecan (Carya illinoinensis)

PubMed Central

Mo, Zhenghai; Feng, Gang; Su, Wenchuan; Liu, Zhuangzhuang; Peng, Fangren

2018-01-01

Pecan (Carya illinoinensis), as a popular nut tree, has been widely planted in China in recent years. Grafting is an important technique for its cultivation. For a successful grafting, graft union development generally involves the formation of callus and vascular bundles at the graft union. To explore the molecular mechanism of graft union development, we applied high throughput RNA sequencing to investigate the transcriptomic profiles of graft union at four timepoints (0 days, 8 days, 15 days, and 30 days) during the pecan grafting process. After de novo assembly, 83,693 unigenes were obtained, and 40,069 of them were annotated. A total of 12,180 differentially expressed genes were identified between by grafting. Genes involved in hormone signaling, cell proliferation, xylem differentiation, cell elongation, secondary cell wall deposition, programmed cell death, and reactive oxygen species (ROS) scavenging showed significant differential expression during the graft union developmental process. In addition, we found that the content of auxin, cytokinin, and gibberellin were accumulated at the graft unions during the grafting process. These results will aid in our understanding of successful grafting in the future. PMID:29401757

The Modular Organization of Protein Interactions in Escherichia coli

PubMed Central

Peregrín-Alvarez, José M.; Xiong, Xuejian; Su, Chong; Parkinson, John

2009-01-01

Escherichia coli serves as an excellent model for the study of fundamental cellular processes such as metabolism, signalling and gene expression. Understanding the function and organization of proteins within these processes is an important step towards a ‘systems’ view of E. coli. Integrating experimental and computational interaction data, we present a reliable network of 3,989 functional interactions between 1,941 E. coli proteins (∼45% of its proteome). These were combined with a recently generated set of 3,888 high-quality physical interactions between 918 proteins and clustered to reveal 316 discrete modules. In addition to known protein complexes (e.g., RNA and DNA polymerases), we identified modules that represent biochemical pathways (e.g., nitrate regulation and cell wall biosynthesis) as well as batteries of functionally and evolutionarily related processes. To aid the interpretation of modular relationships, several case examples are presented, including both well characterized and novel biochemical systems. Together these data provide a global view of the modular organization of the E. coli proteome and yield unique insights into structural and evolutionary relationships in bacterial networks. PMID:19798435

A code-aided carrier synchronization algorithm based on improved nonbinary low-density parity-check codes

NASA Astrophysics Data System (ADS)

Bai, Cheng-lin; Cheng, Zhi-hui

2016-09-01

In order to further improve the carrier synchronization estimation range and accuracy at low signal-to-noise ratio ( SNR), this paper proposes a code-aided carrier synchronization algorithm based on improved nonbinary low-density parity-check (NB-LDPC) codes to study the polarization-division-multiplexing coherent optical orthogonal frequency division multiplexing (PDM-CO-OFDM) system performance in the cases of quadrature phase shift keying (QPSK) and 16 quadrature amplitude modulation (16-QAM) modes. The simulation results indicate that this algorithm can enlarge frequency and phase offset estimation ranges and enhance accuracy of the system greatly, and the bit error rate ( BER) performance of the system is improved effectively compared with that of the system employing traditional NB-LDPC code-aided carrier synchronization algorithm.

Computer aided design of monolithic microwave and millimeter wave integrated circuits and subsystems

NASA Astrophysics Data System (ADS)

Ku, Walter H.

1989-05-01

The objectives of this research are to develop analytical and computer aided design techniques for monolithic microwave and millimeter wave integrated circuits (MMIC and MIMIC) and subsystems and to design and fabricate those ICs. Emphasis was placed on heterojunction-based devices, especially the High Electron Mobility Transition (HEMT), for both low noise and medium power microwave and millimeter wave applications. Circuits to be considered include monolithic low noise amplifiers, power amplifiers, and distributed and feedback amplifiers. Interactive computer aided design programs were developed, which include large signal models of InP MISFETs and InGaAs HEMTs. Further, a new unconstrained optimization algorithm POSM was developed and implemented in the general Analysis and Design program for Integrated Circuit (ADIC) for assistance in the design of largesignal nonlinear circuits.

Combination of Adaptive Feedback Cancellation and Binaural Adaptive Filtering in Hearing Aids

NASA Astrophysics Data System (ADS)

Lombard, Anthony; Reindl, Klaus; Kellermann, Walter

2009-12-01

We study a system combining adaptive feedback cancellation and adaptive filtering connecting inputs from both ears for signal enhancement in hearing aids. For the first time, such a binaural system is analyzed in terms of system stability, convergence of the algorithms, and possible interaction effects. As major outcomes of this study, a new stability condition adapted to the considered binaural scenario is presented, some already existing and commonly used feedback cancellation performance measures for the unilateral case are adapted to the binaural case, and possible interaction effects between the algorithms are identified. For illustration purposes, a blind source separation algorithm has been chosen as an example for adaptive binaural spatial filtering. Experimental results for binaural hearing aids confirm the theoretical findings and the validity of the new measures.

Freshman Year Financial Aid Nudges: An Experiment to Increase Financial Aid Renewal and Sophomore Year Persistence

ERIC Educational Resources Information Center

Castleman, Benjamin L.; Page, Lindsay C.

2013-01-01

While considerable effort has been invested to increase FAFSA completion among high school seniors, there has been much less investment to ensure that college freshmen re-apply for financial aid. Text messaging is a promising approach to inform students of important stages in the financial aid re-application process and to connect them to…

A Self-Instructional Course in Student Financial Aid Administration. Module 3: The Legislative and Regulatory Processes. Second Edition.

ERIC Educational Resources Information Center

Washington Consulting Group, Inc., Washington, DC.

The third of a 17-module self-instructional course on student financial aid administration, this module offers a systematic introduction to the management of federal financial aid programs authorized by Title IV of the Higher Education Act to novice financial aid administrators and other institutional personnel. It teaches the administrator to…

Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.

PubMed

Kawamura, Kiyoko; Wada, Akihiko; Wang, Ji-Yang; Li, Quanhai; Ishii, Akihiro; Tsujimura, Hideki; Takagi, Toshiyuki; Itami, Makiko; Tada, Yuji; Tatsumi, Koichiro; Shimada, Hideaki; Hiroshima, Kenzo; Tagawa, Masatoshi

2016-01-01

Activation-induced cytidine deaminase (AID) is involved in somatic hypermutation and class switch recombination processes in the antibody formation. The AID activity induces gene mutations and could be associated with transformation processes of B cells. Nevertheless, the relation between AID expression and the prognosis of B cell lymphoma patients remains uncharacterized. We examined expression levels of the AID gene in 89 lymph node specimens from lymphoma and non-lymphoma patients with Northern blot analysis and investigated an association with their survival. The AID gene was preferentially expressed in B cell lymphoma in particular in diffuse large B cell lymphoma and follicular lymphoma. We confirmed AID protein expression in the mRNA-positive but not in the negative specimens with Western blot analysis and immunohistochemical staining. Survival of the patients treated with cyclophosphamide-/doxorubicin-/vincristine-/prednisone-based chemotherapy demonstrated that the prognosis of diffuse large B cell patients was unfavorable in the mRNA-positive group compared with the negative group, and that AID expression levels were correlated with the poor prognosis. In contrast, AID expression was not linked with the prognosis of follicular lymphoma patients. AID expression is a predictive marker for an unfavorable outcome in DLBCL patients treated with the chemotherapy.