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Sample records for aip awards industrial

  1. AIPS technology survey report

    NASA Technical Reports Server (NTRS)

    Ogletree, Glenn (Editor)

    1984-01-01

    The results of a technology survey conducted for the NASA/JSC by the CSDL during Phase 1 of the NASA Advanced Information Processing System (AIPS) program at the CSDL are discussed. The purpose of the survey was to ensure that all technology relevant to the configuration, design, development, verification, implementation, and validation of an advanced information processing system, whether existing or under development and soon to be available, would be duly considered in the development of the AIPS. The emphasis in the survey was on technology items which were clearly relevant to the AIPS. Requirements were developed which guided the planning of contacts with the outside sources to be surveyed, and established practical limits on the scope and content of the Technology Survey. Subjects surveyed included architecture, software, hardware, methods for evaluation of reliability and performance, and methods for the verification of the AIPS design and the validation of the AIPS implementation. Survey requirements and survey results in each of these areas are presented, including analyses of the potential effects on the AIPS development process of using or not using the surveyed technology items. Another output of the survey was the identification of technology areas of particular relevance to the AIPS and for which further development, in some cases by the CSDL and in some cases by the NASA, would be fruitful. Appendices are provided in which are presented: (1) reports of some of the actual survey interactions with industrial and other outside information sources; (2) the literature list from the comprehensive literature survey which was conducted; (3) reduced-scale images of an excerpt ('Technology Survey' viewgraphs) from the set of viewgraphs used at the 14 April 1983 Preliminary Requirements Review by the CSDL for the NASA; and (4) reduced-scale images of the set of viewgraphs used in the AIPS Technology Survey Review presentation to the NASA monitors by the CSDL at

  2. AIP Career Pathways

    NASA Astrophysics Data System (ADS)

    Palchak, Amanda

    2012-02-01

    American Institute of Physics (AIP) Career Pathways is a new project funded by the National Science Foundation. One of the goals of AIP Career Pathways is to prepare students to compete for Science, Technology, Engineering, and Mathematics (STEM) careers with a bachelor's degree in physics. In order to do so, I reviewed and compiled useful resources on finding a STEM career with a bachelor's degree in physics. These resources not only supply the job seeker with job postings in STEM careers but also provide them with information on resumes, interviewing skills, and networking. Recently at the 2011 Industrial Physics Forum, I interviewed companies in the private sector to obtain a unique perspective on what types of skills potential employers expect an applicant to posses with a bachelor's degree in physics. Ultimately, these components will be used as supplements at student career workshops held at annual Society of Physics Students Zone Meetings.

  3. NASA 2012 Small Business Industry Awards (SBIA)

    NASA Image and Video Library

    2013-04-23

    NASA Administrator Charles Bolden, left, NASA Associate Administrator for Small Business Programs Glenn A. Delgado, and NASA Deputy Administrator Lori Garver, right, pose for a photograph with Autumn Sellars, President/CEO of A2Research of Huntsville, Alabama after the company was awarded the Small Business Prime Contractor of the Year at NASA Headquarters, Tuesday, April 23, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  4. NASA 2012 Small Business Industry Awards (SBIA)

    NASA Image and Video Library

    2013-04-23

    NASA Administrator Charles Bolden, left, NASA Associate Administrator for Small Business Programs Glenn A. Delgado, second from left, and NASA Deputy Administrator Lori Garver, right, pose for a photograph with Patricia Rice, Manager, Supplier Diversity, Small Business Liaison Officer & Supplier Development, Pratt & Whitney Rocketdyne, Inc. and Jim Maser, President of Pratt & Whitney Rocketdyne, Inc. of East Hartford, Connecticut after the company was awarded the Large Business Prime Contractor of the Year at NASA Headquarters, Tuesday, April 23, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  5. Acute Intermittent Porphyria (AIP)

    MedlinePlus

    ... the Healthcare Professionals area of our site. PBS Documentary AIP Diagnosis Stories **Diagnostic Testing for the Acute ... treating AIP are based upon experience and clinical study. Since many commonly used drugs have not been ...

  6. Report on AIP--1971

    ERIC Educational Resources Information Center

    Physics Today, 1972

    1972-01-01

    The 1971 annual report by the American Institute of Physics (AIP) is highlighted. The report deals with AIP activities during 1971, including changes in publishing methods, new products from the physics-information division, and internal reorganization for better service. (PR)

  7. AIP mutations and gigantism.

    PubMed

    Rostomyan, Liliya; Potorac, Iulia; Beckers, Pablo; Daly, Adrian F; Beckers, Albert

    2017-06-01

    AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Programmability in AIPS++

    NASA Technical Reports Server (NTRS)

    Hjellming, R. M.

    1992-01-01

    AIPS++ is an Astronomical Information Processing System being designed and implemented by an international consortium of NRAO and six other radio astronomy institutions in Australia, India, the Netherlands, the United Kingdom, Canada, and the USA. AIPS++ is intended to replace the functionality of AIPS, to be more easily programmable, and will be implemented in C++ using object-oriented techniques. Programmability in AIPS++ is planned at three levels. The first level will be that of a command-line interpreter with characteristics similar to IDL and PV-Wave, but with an intensive set of operations appropriate to telescope data handling, image formation, and image processing. The third level will be in C++ with extensive use of class libraries for both basic operations and advanced applications. The third level will allow input and output of data between external FORTRAN programs and AIPS++ telescope and image databases. In addition to summarizing the above programmability characteristics, this talk will given an overview of the classes currently being designed for telescope data calibration and editing, image formation, and the 'toolkit' of mathematical 'objects' that will perform most of the processing in AIPS++.

  9. AIP appoints New CEO

    NASA Astrophysics Data System (ADS)

    The American Institute of Physics (AIP) has announced the appointment of a new chief executive officer, Kenneth W. Ford, who is to succeed H. William Koch when Koch retires on March 28, 1987. Koch has held the position since 1966.AIP is a not-for-profit scientific organization made up of 10 member societies, including AGU, that represent more than 90,000 scientists. Its main activities include scientific publishing and marketing of 76 primary physics journals, including translations of foreign journals, books, conference proceedings, and the magazine Physics Today. AIP also is involved with electronic abstracting and other scientific communications and has active programs in education, public information, manpower statistics, and the history of physics.

  10. AIP Member Societies Entering the 1980's. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    Information is presented on the composition of the 1979 membership of the American Institute of Physics (AIP). Questionnaires were administered to members of the nine independent societies of the AIP to determine demographic and employment information. Background characteristics of the membership include the following: more than half identify…

  11. AIP Member Societies Entering the 1980's. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    Information is presented on the composition of the 1979 membership of the American Institute of Physics (AIP). Questionnaires were administered to members of the nine independent societies of the AIP to determine demographic and employment information. Background characteristics of the membership include the following: more than half identify…

  12. Industrial Energy Efficiency Practices in Indonesia: Lesson Learned from Astra Green Energy (AGen) Award

    NASA Astrophysics Data System (ADS)

    Telaga, A. S.; Hartanto, I. D.

    2017-03-01

    Many countries have used award system to promote energy efficiency practices in industry. The award system has been found to have significant impact to increase energy conservation and sustainability adoption in companies. Astra International (AI) as a holding company of more than 200 companies also organised Astra green energy (AGen) award to all affiliated companies (AFFCO) in Astra group. The event has been used to share energy efficiency best practices among AFFCO in Astra group. AFFCOs of Astra International are among the biggest and the leader in their industrial sectors Therefore, analyses from AFFO’s energy efficiency case studies represents current practices in Indonesia industrial sectors. Analyses are divided into industry, building, and renewable energy. The results from analyses found that AFFCOs already aware of energy conservation and have implemented projects to promote energy efficiency. However, the AFFCOs do not optimally use monitoring data for energy reduction.

  13. AIP's Career Pathways Project

    NASA Astrophysics Data System (ADS)

    Avila, Jose

    2014-03-01

    The American Institute of Physics (AIP) Career Pathways Project, funded by the National Science Foundation, aims to increase the number of undergraduates going into STEM careers. The main purposes of this project are to show students the professional opportunities for a STEM career, understand what departments can do to better prepare physics bachelor's degree recipients to enter the workforce, understand what students can do to better prepare themselves, and develop resources based on these findings. I was chosen by the Society of Physics Students (SPS) to be the 2013 summer intern of the AIP's Career Pathways Project. In this talk I will discuss several resources I worked on with the Statistical Research Center of the American Institute of Physics and SPS. These resources include how to write a resume and cover letter, how to perform an informational interview, common job titles for physics bachelors, how to find career information in physics and STEM, how to search and use job postings, and how to network.

  14. AIP and its interacting partners.

    PubMed

    Trivellin, Giampaolo; Korbonits, Márta

    2011-08-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to young-onset pituitary tumours, most often to GH- or prolactin-secreting adenomas, and most of these patients belong to familial isolated pituitary adenoma families. The molecular pathway initiated by the loss-of-function AIP mutations leading to pituitary tumour formation is unknown. AIP, a co-chaperone of heat-shock protein 90 and various nuclear receptors, belongs to the family of tetratricopeptide repeat (TPR)-containing proteins. It has three antiparallel α-helix motifs (TPR domains) that mediate the interaction of AIP with most of its partners. In this review, we summarise the known interactions of AIP described so far. The identification of AIP partners and the understanding of how AIP interacts with these proteins might help to explain the specific phenotype of the families with heterozygous AIP mutations, to gain deeper insight into the pathological process of pituitary tumour formation and to identify novel drug targets.

  15. Reduced rates for AIP journals

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    The American Institute of Physics (AIP) offers reduced rates for subscriptions of its journals to individual members of affiliated societies. AGU is an A IP-affiliated society. The offer is limited to one subscription per person to each journal.

  16. Reduced rates for AIP journals

    NASA Astrophysics Data System (ADS)

    The American Institute of Physics (AIP) offers reducedrate subscriptions of its journals to individual members of affiliated societies, including AGU. The offer is limited to one subscription per person to each journal.

  17. Graedel named to AIP Board

    NASA Astrophysics Data System (ADS)

    Maggs, William Ward

    Thomas E. Graedel, an atmospheric scientist at AT&T Bell Laboratories (Murray Hill, N.J.), has been made an AGU representative to the Governing Board of the American Institute of Physics (AIP). The board oversees the operations of AIP, a nonprofit umbrella organization for 10 member societies, including AGU. Other AGU members currently on the governing board include Orson Anderson, a geophysicist at the University of California, Los Angeles; AGU General Secretary Peter M. Bell of the Norton Company, Worcester, Mass.; AGU Executive Director A. F. Spilhaus, Jr.; and Martin Walt, a geophysicist with the Lockheed Corporation in Palo Alto, Calif.All AGU members receive the benefits of membership in AIP, including the monthly magazine Physics Today. Other AIP services available to AGU members include access to an employment service, AIP's electronic network Pi-NET, and an insurance program. AGU members can also subscribe to journals published by the American Physical Society, another AIP member society, at discounted rates.—WWM

  18. Coastal and Marine Operators Group Receives Second-Place Gulf Guardian Award in Business and Industry Category

    EPA Pesticide Factsheets

    DALLAS - (July 30, 2015) The Gulf of Mexico Program recently announced Coastal and Marine Operations (CAMO) Group will receive a Second Place 2015 Gulf Guardian Award in the Business and Industry Category. The awards ceremony will be held on July 30

  19. Award Restructuring and the Implications for TAFE with Reference to the Restructuring Being Undertaken within the Textiles and Metals Industry.

    ERIC Educational Resources Information Center

    Chataway, Graham

    A study investigated the human and physical resources implications of award restructuring in the textiles and metals industries for the Technical and Further Education (TAFE) system in Australia. (Award restructuring is based on union/employer cooperation in a process of negotiation and compromise between employers committed to increased…

  20. Advanced Information Processing System (AIPS)

    NASA Technical Reports Server (NTRS)

    Pitts, Felix L.

    1993-01-01

    Advanced Information Processing System (AIPS) is a computer systems philosophy, a set of validated hardware building blocks, and a set of validated services as embodied in system software. The goal of AIPS is to provide the knowledgebase which will allow achievement of validated fault-tolerant distributed computer system architectures, suitable for a broad range of applications, having failure probability requirements of 10E-9 at 10 hours. A background and description is given followed by program accomplishments, the current focus, applications, technology transfer, FY92 accomplishments, and funding.

  1. Employment Survey 1976. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    This document presents the summary results of the 1976 employment survey of physics and astronomy graduates of the class of 1975-76 as conducted by the American Institute of Physics (AIP). Data presented include employment status 6-18 months after graduation; background characteristics of doctoral, master's and bachelor's level physicists; time…

  2. Employment Survey 1976. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    This document presents the summary results of the 1976 employment survey of physics and astronomy graduates of the class of 1975-76 as conducted by the American Institute of Physics (AIP). Data presented include employment status 6-18 months after graduation; background characteristics of doctoral, master's and bachelor's level physicists; time…

  3. Creating New Incentives for Risk Identification and Insurance Process for the Electric Utility Industry (initial award through Award Modification 2); Energy & Risk Transfer Assessment (Award Modifications 3 - 6)

    SciTech Connect

    Michael Ebert

    2008-02-28

    This is the final report for the DOE-NETL grant entitled 'Creating New Incentives for Risk Identification & Insurance Processes for the Electric Utility Industry' and later, 'Energy & Risk Transfer Assessment'. It reflects work done on projects from 15 August 2004 to 29 February 2008. Projects were on a variety of topics, including commercial insurance for electrical utilities, the Electrical Reliability Organization, cost recovery by Gulf State electrical utilities after major hurricanes, and review of state energy emergency plans. This Final Technical Report documents and summarizes all work performed during the award period, which in this case is from 15 August 2004 (date of notification of original award) through 29 February 2008. This report presents this information in a comprehensive, integrated fashion that clearly shows a logical and synergistic research trajectory, and is augmented with findings and conclusions drawn from the research as a whole. Four major research projects were undertaken and completed during the 42 month period of activities conducted and funded by the award; these are: (1) Creating New Incentives for Risk Identification and Insurance Process for the Electric Utility Industry (also referred to as the 'commercial insurance' research). Three major deliverables were produced: a pre-conference white paper, a two-day facilitated stakeholders workshop conducted at George Mason University, and a post-workshop report with findings and recommendations. All deliverables from this work are published on the CIP website at http://cipp.gmu.edu/projects/DoE-NETL-2005.php. (2) The New Electric Reliability Organization (ERO): an examination of critical issues associated with governance, standards development and implementation, and jurisdiction (also referred to as the 'ERO study'). Four major deliverables were produced: a series of preliminary memoranda for the staff of the Office of Electricity Delivery and Energy Reliability ('OE'), an ERO interview

  4. Engineering and Scientific Training Schemes, Including Industrial Awards for Degree Courses for Those Leaving School in 1972 and 1973.

    ERIC Educational Resources Information Center

    Hills, Joan, Ed.

    This revised edition of a 1955 publication is designed to help those who have chosen careers in engineering or science, and in particular, those who wish to pursue their technical training in some association with industry on leaving school. The introduction discusses: changes in this edition; trends in sandwich training; industrial awards; how to…

  5. AIP Member Societies Entering the 1980's.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    1981-01-01

    Summarizes results of a survey conducted by the Manpower Statistics Division of the American Institute of Physics (AIP). Questions were asked of nine member societies of the AIP concerning demographic and employment data such as professional self-identification, type of employer by highest degree, primary work activity, and annual salary. (CS)

  6. EPA Honors PRIDE Industries with Safer Choice Partner of the Year Award

    EPA Pesticide Factsheets

    SAN FRANCISCO - The U.S. Environmental Protection Agency awarded its first ever Safer Choice Partner of the Year awards for outstanding achievement in the design, manufacture, promotion and use of environmentally friendly products in the nation's homes, sc

  7. AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic responses

    PubMed Central

    Zhou, Huanjiao Jenny; Chen, Xiaodong; Liu, Renjing; Zhang, Haifeng; Wang, Yingdi; Jin, Yu; Liang, Xiaoling; Lu, Lin; Xu, Zhe; Min, Wang

    2014-01-01

    Objective To investigate the novel function of AIP1 in VEGFR-3 signaling, and VEGFR-3-dependent angiogenesis and lymphangiogenesis. Approach/Results AIP1, a signaling scaffold protein, is highly expressed in the vascular endothelium. We have previously reported that AIP1 functions as an endogenous inhibitor in pathological angiogenesis by blocking VEGFR-2 activity. Surprisingly, here we observe that mice with a global deletion of AIP1 (AIP1-KO) exhibit reduced retinal angiogenesis with less sprouting and fewer branches. Vascular endothelial cell (but not neuronal)-specific deletion of AIP1 causes similar defects in retinal angiogenesis. The reduced retinal angiogenesis correlates with reduced expression in VEGFR-3 despite increased VEGFR-2 levels in AIP1-KO retinas. Consistent with the reduced expression of VEGFR-3, AIP1-KO mice show delayed developmental lymphangiogenesis in neonatal skin and mesentery, and mount weaker VEGF-C-induced cornea lymphangiogenesis. In vitro, human lymphatic EC with AIP1 siRNA knockdown, retinal EC and lymphatic EC isolated from AIP1-KO all show attenuated VEGF-C-induced VEGFR-3 signaling. Mechanistically, we demonstrate that AIP1 via vegfr-3-specific miR-1236 increases VEGFR-3 protein expression, and by directly binding to VEGFR-3 enhances VEGFR-3 endocytosis and stability. Conclusion Our in vivo and in vitro results provide the first insight into the mechanism by which AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic signaling. PMID:24407031

  8. Bachelor's Degree Recipients Report 1995. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Dodge, Elizabeth

    This document reports on a 1995 survey of students graduating with a bachelor's degree in physics or astronomy as part of an ongoing series of surveys that have been conducted by the American Institute of Physics (AIP) since the 1960s. The data obtained on the 1995 class build upon established trends in students' immediate postbaccalaureate plans…

  9. Validation environment for AIPS/ALS: Implementation and results

    NASA Technical Reports Server (NTRS)

    Segall, Zary; Siewiorek, Daniel; Caplan, Eddie; Chung, Alan; Czeck, Edward; Vrsalovic, Dalibor

    1990-01-01

    The work is presented which was performed in porting the Fault Injection-based Automated Testing (FIAT) and Programming and Instrumentation Environments (PIE) validation tools, to the Advanced Information Processing System (AIPS) in the context of the Ada Language System (ALS) application, as well as an initial fault free validation of the available AIPS system. The PIE components implemented on AIPS provide the monitoring mechanisms required for validation. These mechanisms represent a substantial portion of the FIAT system. Moreover, these are required for the implementation of the FIAT environment on AIPS. Using these components, an initial fault free validation of the AIPS system was performed. The implementation is described of the FIAT/PIE system, configured for fault free validation of the AIPS fault tolerant computer system. The PIE components were modified to support the Ada language. A special purpose AIPS/Ada runtime monitoring and data collection was implemented. A number of initial Ada programs running on the PIE/AIPS system were implemented. The instrumentation of the Ada programs was accomplished automatically inside the PIE programming environment. PIE's on-line graphical views show vividly and accurately the performance characteristics of Ada programs, AIPS kernel and the application's interaction with the AIPS kernel. The data collection mechanisms were written in a high level language, Ada, and provide a high degree of flexibility for implementation under various system conditions.

  10. Immunogenetics of IgG4-Related AIP.

    PubMed

    Ota, Masao; Umemura, Takeji; Kawa, Shigeyuki

    2017-01-01

    Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis characterized by high serum IgG4 concentration and a variety of complicating extra-pancreatic lesions. AIP has the features of a complex disease that is caused by multifactorial genes. However, the genetic factors underlying AIP have not been elucidated conclusively. Association studies by the candidate-gene approach and genome-wide association studies (GWAS) have revealed several susceptibility genes for AIP, including HLA DRB1*04:05-DQB1*04:01, FCRL3, CTLA4, and KCNA3, albeit in small-scale analyses. Thus, GWAS of large sample sizes and multinational collaborative meta-analyses are needed to identify the precise genetic variants that are associated with AIP onset. Systems genetics approaches that integrate DNA sequencing, expression quantitative trait locus (eQTL) mapping, proteomics, and metabolomics will also be useful in clarifying the pathogenesis of AIP.

  11. AIP 50th anniversary: Physics vade mecum

    NASA Astrophysics Data System (ADS)

    Anderson, H. L.

    This compendium is intended to be of use to the wide spectrum of physicists associated with the AIP through its member societies. Twenty-two subjects broadly representative of physics as a whole are discussed. Each subeditor was charged to compile within 10 pages the most useful information, formulas, numerical data, definitions, and references most physicists would like to have at hand. The General Section is a compilation of the fundamental constants, the SI units and prefixes, conversion factors, magnitudes, basic mathematical and physics formulas, formulas useful in practical physics applications, and a list of physics data centers. The particular fields considered are: acoustics, astronomy and astrophysics, atomic collision properties, atomic spectroscopy, biological physics, cryogenics, crystallography, elementary particles, energy demand, energy supply, fluid dynamics, high polymer physics, medical physics, molecular spectroscopy and structure, nuclear physics, optics, plasma physics, rheology, solid state physics, surface physics, and thermophysics.

  12. Resources for History of Geophysics at AIP

    NASA Astrophysics Data System (ADS)

    Good, G. A.

    2012-12-01

    The history programs of the American Institute of Physics -- the Center for History of Physics and the Niels Bohr Library & Archives -- maintain a wide variety of research resources for the history of physics generally, and for the history of geophysics in particular. AIP has over 20,000 photographs online, nearly 1000 oral history interview transcripts, and much more. The International Catalog of Sources provides an online union catalog of manuscript collections held worldwide. An important collection of IUGG records is available onsite, as also is the recently accessioned collection of AGU papers. As the 2019 centenary of AGU approaches, these resources will be of interest to both AGU members and historians of science.;

  13. AIP to Process AGU Renewals for 2005

    NASA Astrophysics Data System (ADS)

    Spilhaus, Fred

    2004-09-01

    AGU is collaborating with the American Institute of Physics (AIP) to provide improved online renewal of your membership and subscription starting with 2005 payments. The renewal process whether online or via mail will be easy for you. I would like to encourage each of you to renew early using the online form. You will be saving the Union money by cutting down on the cost of paper renewals. As a thank-you, members who renew within the first weeks will receive 2005 access without charge to the AGU Member Library of online back issues of all journals. At the same time you can help assure that your information has been correctly transferred to the new database. Great care has been taken in the transition; however, a check by you will assure your information is current.

  14. Molecular genetics of the aip gene in familial pituitary tumorigenesis.

    PubMed

    Tahir, Asil; Chahal, Harvinder S; Korbonits, Márta

    2010-01-01

    Pituitary adenomas usually occur as sporadic tumors, but familial cases are now increasingly identified. As opposed to multiple endocrine neoplasia type 1 and Carney complex, in familial isolated pituitary adenoma (FIPA) syndrome no other disease is associated with the familial occurrence of pituitary adenomas. It is an autosomal dominant disease with incomplete variable penetrance. Approximately 20% of patients with FIPA harbour germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene located on 11q13. Patients with AIP mutations have an overwhelming predominance of somatotroph and lactotroph adenomas, which often present in childhood or young adulthood. AIP, originally identified as a molecular co-chaperone of several nuclear receptors, is thought to act as a tumor suppressor gene; overexpression of wild-type, but not mutant AIP, reduces cell proliferation while knockdown of AIP stimulates it. AIP is shown to bind various proteins, including the aryl hydrocarbon receptor, Hsp90, phosphodiesterases, survivin, RET and the glucocorticoid receptor, but currently it is not clear which interaction has the leading role in pituitary tumorigenesis. This chapter summarizes the available clinical and molecular data regarding the role of AIP in the pituitary gland.

  15. AIP history center seeks old books and photographs

    NASA Astrophysics Data System (ADS)

    AGU members can give essential help to an effort to gather materials that are important for education and public understanding of geophysics. Now that AGU is a Member Society of the American Institute of Physics (AIP), the AIP Center for History of Physics is striving to enlarge its collections of materials on the history of geophysics. They are appealing to AGU members to help AIP locate and acquire materials, such as classic textbooks and old snapshots, that will be invaluable to future historians and educators.

  16. CHP Awards Announced

    SciTech Connect

    2010-05-01

    The U.S. Department of Energy Industrial Technologies Program has selected six projects for financial awards under the "Combined Heat and Power Systems Technology Development and Demonstration" solicitation (DE-FOA-0000016).

  17. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.

    PubMed

    Zhang, Jiqin; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang

    2015-05-01

    AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC). While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein). Human genome-wide association study (GWAS) has identified DAB2IP gene variants conferring susceptibility to cardiovascular diseases. Consistently, a global or vascular EC-specific deletion of DAB2IP in mice strongly enhances inflammatory responses and exacerbates atherosclerosis and graft arteriosclerosis progression in mouse models. Mechanisms for AIP1 function and regulation associated with human cardiovascular diseases need further investigations.

  18. Developing Industry-Sponsored Entrepreneurship Education Programmes. The Experiences of the Coca-Cola National Enterprise Award.

    ERIC Educational Resources Information Center

    Henry, Colette; Titterington, Albert; Wiseman, Kate

    1998-01-01

    A partnership among Dundalk Institute of Technology (Ireland), Coca Cola, and government encourages young entrepreneurs through formal education in business management, workshops, mentoring, and financial rewards provided by the corporation's National Enterprise Award. (SK)

  19. Developing Industry-Sponsored Entrepreneurship Education Programmes. The Experiences of the Coca-Cola National Enterprise Award.

    ERIC Educational Resources Information Center

    Henry, Colette; Titterington, Albert; Wiseman, Kate

    1998-01-01

    A partnership among Dundalk Institute of Technology (Ireland), Coca Cola, and government encourages young entrepreneurs through formal education in business management, workshops, mentoring, and financial rewards provided by the corporation's National Enterprise Award. (SK)

  20. Cortical connections of the macaque anterior intraparietal (AIP) area.

    PubMed

    Borra, Elena; Belmalih, Abdelouahed; Calzavara, Roberta; Gerbella, Marzio; Murata, Akira; Rozzi, Stefano; Luppino, Giuseppe

    2008-05-01

    We traced the cortical connections of the anterior intraparietal (AIP) area, which is known to play a crucial role in visuomotor transformations for grasping. AIP displayed major connections with 1) areas of the inferior parietal lobule convexity, the rostral part of the lateral intraparietal area and the SII region; 2) ventral visual stream areas of the lower bank of the superior temporal sulcus and the middle temporal gyrus; and 3) the premotor area F5 and prefrontal areas 46 and 12. Additional connections were observed with the caudal intraparietal area and the ventral part of the frontal eye field. This study suggests that visuomotor transformations for object-oriented actions, processed in AIP, rely not only on dorsal visual stream information related to the object's physical properties but also on ventral visual stream information related to object identity. The identification of direct anatomical connections with the inferotemporal cortex suggests that AIP also has a unique role in linking the parietofrontal network of areas involved in sensorimotor transformations for grasping with areas involved in object recognition. Thus, AIP could represent a crucial node in a cortical circuit in which hand-related sensory and motor signals gain access to representations of object identity for tactile object recognition.

  1. On AIPS++, a new astronomical information processing system

    NASA Technical Reports Server (NTRS)

    Croes, G. A.

    1992-01-01

    The AIPS system that has served the needs of the radio astronomical community remarkably well during the last 15 years is showing signs of age and is being replaced by a more modern system, AIPS++. As the name implies, AIPS++ will be developed in a object oriented fashion and will use C++ as its main programming language. The work is being done by a consortium of seven organizations, with coordinated activities worldwide. After a review of the history of the project to this date from management, astronomical and technical viewpoints, and the current state of the project, the paper concentrates on the tradeoffs implied by the choice of implementation style and the lessons we have learned, good and bad.

  2. 76 FR 44978 - Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ...-0786] Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds AGENCY... Program (AIP) must notify, in writing, the designated representative in the appropriate FAA Regional or... grants to the following year. In such cases, the FAA converts the current-year funds to AIP...

  3. Some Comments on Marketing AIP Information Products and Services.

    ERIC Educational Resources Information Center

    King, Donald W.; Brown, A. M.

    This study was addressed to marketing considerations for the American Institute of Physics (AIP) information products and services. The general system and its operation in a marketing environment, including promotion, channels of distribution and pricing are covered. Particular emphasis is placed on the cost/demand/price relationship for four…

  4. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease

    PubMed Central

    Niroumand, Shabnam; Khajedaluee, Mohammad; Khadem-Rezaiyan, Majid; Abrishami, Maryam; Juya, Mohammadreza; Khodaee, Gholamhasan; Dadgarmoghaddam, Maliheh

    2015-01-01

    Background: Cardiovascular disease (CVD) is the cause of one third of deaths worldwide and this will progress because of increasing CVD's risk factors. The most basic task of dealing with the epidemic of CVD is primary prevention of risk factors. As Atherogenic Index of Plasma (AIP) is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the correlation between AIP and other important factors. Methods: This cross-sectional study was a part of national non-communicable risk factors surveillance system data that has been established since 2004 in Iran. This was done on 1000 people between 2008 and 2010. The study was approved by Ethics Committee of Mashhad University of Medical Science. Chi square, Mann-Whitney U, correlation tests were used in this study. Statistical analysis was performed using SPSS version 11. In all calculations, p <0.05 was considered as statistically significant level. Results: The study population consisted of 500 men and 500 women with mean±SD age 41.9±14.2 years. According to the AIP category, 9.8% (98) were in low risk group, 12.7% (127) were in intermediate risk and 77.5% (775) were in increased risk of CVD. AIP was significantly correlated with waist circumference (r=0.35, p<0.001), BMI (r=0.33, p<0.001) and physical activity (r=-0.09, p<0.01). Conclusion: AIP can be used as a regular monitoring index of CVD in every day practice, especially in persons with other cardiovascular risk factors. PMID:26793631

  5. NanoMech, US EPA SBIR Award Recipient: 2014 Tibbetts Award Winner

    EPA Pesticide Factsheets

    NanoMech, a EPA SBIR award recipient in 2004 and 2005, received the 2014 Tibbetts Award for its coating technology, which can improve manufacturing processes by extending the life of tools used in automotive and aerospace industries.

  6. Stennis award

    NASA Image and Video Library

    2012-04-20

    NASA Administrator Charles Bolden (l) and NASA Small Business Programs Associate Administrator Glenn Delgado (r) present NASA's Small Business Administrator's Cup Award to Stennis Space Center in recognition of its stellar small business program for fiscal year 2011. Receiving the award April 20, 2012, are (l to r) Stennis Procurement Office personnel Michelle Stracener and Rob Harris, along with Stennis Space Center Director Patrick Scheuermann. Bolden and Delgado presented the award during an onsite visit April 20.

  7. Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

    PubMed

    Scudder, C J; Niessen, S J; Catchpole, B; Fowkes, R C; Church, D B; Forcada, Y

    2017-04-01

    Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human acromegalic families with AIP mutations. The aim of this study was to sequence the feline AIP gene, identify sequence variants and compare the AIP gene sequence between feline acromegalic and control cats, and in acromegalic siblings. The feline AIP gene was amplified through PCR using whole blood genomic DNA from 10 acromegalic and 10 control cats, and 3 sibling pairs affected by acromegaly. PCR products were sequenced and compared with the published predicted feline AIP gene. A single nonsynonymous SNP was identified in exon 1 (AIP:c.9T > G) of two acromegalic cats and none of the control cats, as well as both members of one sibling pair. The region of this SNP is considered essential for the interaction of the AIP protein with its receptor. This sequence variant has not previously been reported in humans. Two additional synonymous sequence variants were identified (AIP:c.481C > T and AIP:c.826C > T). This is the first molecular study to investigate a potential genetic cause of feline acromegaly and identified a nonsynonymous AIP single nucleotide polymorphism in 20% of the acromegalic cat population evaluated, as well as in one of the sibling pairs evaluated.

  8. Educator Award

    NASA Astrophysics Data System (ADS)

    The Association for Women Geoscientists Foundation is seeking nominations for its second Outstanding Educator Award, which will be given October 30, 1990, at the Geological Society of America meeting in Dallas, Tex.The award was established to honor college and university teachers who have demonstrated support for women students both inside and outside the classroom.

  9. An AIPS++ Commissioning Tool for the Green Bank Telescope

    NASA Astrophysics Data System (ADS)

    Braatz, J.; McMullin, J.; Garwood, R.; Maddalena, R.; Norrod, R.

    1999-12-01

    The Green Bank Telescope (GBT) is a 100-m diameter antenna with an unblocked aperture and an active surface. It is designed to observe at frequencies from 300 MHz to 100 GHz. Construction of the telescope is now in the final phase - installation of the surface panels - and will be completed in early 2000. The electronics systems for the telescope have been under development and testing in a "Mock-up" which includes the receivers, LO systems, analog filters, and the backends. Upon completion of construction, the telescope will undergo a series of commissioning procedures to prepare for general astronomical observing. We will illustrate the software tools being developed in support of the engineering tests and commissioning requirements of the GBT. These requirements include analysis of holography data, which will be used to measure the initial surface accuracy of the dish. This software is being developed in the AIPS++ programming environment using Glish, a powerful scripting language adopted by the AIPS++ system.

  10. Familial pituitary adenomas - who should be tested for AIP mutations?

    PubMed

    Korbonits, Márta; Storr, Helen; Kumar, Ajith V

    2012-09-01

    Familial Isolated Pituitary Adenomas (FIPA), an autosomal dominant disease with low penetrance is being increasingly recognized. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. Patients with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are characterized by young-onset somatotroph or lactotroph macroadenomas, while in the other, larger group of FIPA patients with typically adult-onset disease and more varied adenoma types, no causative gene(s) has been identified. Young-onset macroadenoma patients can also be identified with germline AIP mutation without an apparent family history. Further data and longer follow-up are necessary to establish formal guidelines, but the current data suggest genetic screening of the AIP gene in patients with a pituitary adenoma and no other associated features who have (i) a family history of pituitary adenoma, (ii) childhood-onset pituitary adenoma or (iii) a pituitary somatotroph or lactotroph macroadenoma diagnosed before the age of 30 years.

  11. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

    PubMed

    Hassan, Wail M; Merin, David A; Fonte, Virginia; Link, Christopher D

    2009-08-01

    Multiple neurodegenerative diseases are causally linked to aggregation-prone proteins. Cellular mechanisms involving protein turnover may be key defense mechanisms against aggregating protein disorders. We have used a transgenic Caenorhabditis elegans Alzheimer's disease model to identify cellular responses to proteotoxicity resulting from expression of the human beta amyloid peptide (Abeta). We show up-regulation of aip-1 in Abeta-expressing animals. Mammalian homologues of AIP-1 have been shown to associate with, and regulate the function of, the 26S proteasome, leading us to hypothesize that induction of AIP-1 may be a protective cellular response directed toward modulating proteasomal function in response to toxic protein aggregation. Using our transgenic model, we show that overexpression of AIP-1 protected against, while RNAi knockdown of AIP-1 exacerbated, Abeta toxicity. AIP-1 overexpression also reduced accumulation of Abeta in this model, which is consistent with AIP-1 enhancing protein degradation. Transgenic expression of one of the two human aip-1 homologues (AIRAPL), but not the other (AIRAP), suppressed Abeta toxicity in C. elegans, which advocates the biological relevance of the data to human biology. Interestingly, AIRAPL and AIP-1 contain a predicted farnesylation site, which is absent from AIRAP. This farnesylation site was shown by others to be essential for an AIP-1 prolongevity function. Consistent with this, we show that an AIP-1 mutant lacking the predicted farnesylation site failed to protect against Abeta toxicity. Our results implicate AIP-1 in the regulation of protein turnover and protection against Abeta toxicity and point at AIRAPL as the functional mammalian homologue of AIP-1.

  12. Characterization of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Mutations in Familial Isolated Pituitary Adenoma Families

    PubMed Central

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-01-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15–40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and β-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6±11.2 years) than AIP mutation-negative patients (40.4±14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein–protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants. Hum Mutat 31:1–11, 2010. © 2010 Wiley-Liss, Inc. PMID:20506337

  13. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.

    PubMed

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-08-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15-40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and beta-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6+/-11.2 years) than AIP mutation-negative patients (40.4+/-14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein-protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants.

  14. An analysis of six cases of acute intermittent porphyria (AIP)

    PubMed Central

    Ghosh, Soumitra; Chaudhury, Pranit KR.; Goswami, Hiranya K.

    2006-01-01

    This analysis describes the diagnosis and psychiatric treatment modalities of 6 patients (5 women, 1 man; mean age 28.5 years) of acute intermittent porphyria (AIP), who presented to the Psychiatry OPD over a period of one year. The mean number of episodes was 2.83. Premorbid personality traits, clinical presentation, urine colour and urinary porphobilinogen titre were recorded. Among the 6 patients, 4 had abdominal pain, 5 had autonomic instability, all 6 had mental symptoms, 3 had depression, 2 came in delirium, and 3 had an episode of seizure. PMID:20844651

  15. 28 CFR 345.72 - Cash bonus or cash award.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Cash bonus or cash award. 345.72 Section 345.72 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.72 Cash bonus or cash award. An inmate worker may...

  16. 28 CFR 345.72 - Cash bonus or cash award.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Cash bonus or cash award. 345.72 Section 345.72 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.72 Cash bonus or cash award. An inmate worker may...

  17. 28 CFR 345.72 - Cash bonus or cash award.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Cash bonus or cash award. 345.72 Section 345.72 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.72 Cash bonus or cash award. An inmate worker may...

  18. 28 CFR 345.72 - Cash bonus or cash award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Cash bonus or cash award. 345.72 Section 345.72 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.72 Cash bonus or cash award. An inmate worker may...

  19. 28 CFR 345.72 - Cash bonus or cash award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Cash bonus or cash award. 345.72 Section 345.72 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.72 Cash bonus or cash award. An inmate worker may...

  20. AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.

    PubMed

    Tuominen, I; Heliövaara, E; Raitila, A; Rautiainen, M-R; Mehine, M; Katainen, R; Donner, I; Aittomäki, V; Lehtonen, H J; Ahlsten, M; Kivipelto, L; Schalin-Jäntti, C; Arola, J; Hautaniemi, S; Karhu, A

    2015-02-26

    The aryl hydrocarbon receptor interacting protein (AIP) is a tumor-suppressor gene underlying the pituitary adenoma predisposition. Thus far, the exact molecular mechanisms by which inactivated AIP exerts its tumor-promoting action have been unclear. To better understand the role of AIP in pituitary tumorigenesis, we performed gene expression microarray analysis to examine changes between Aip wild-type and knockout mouse embryonic fibroblast (MEF) cell lines. Transcriptional analyses implied that Aip deficiency causes a dysfunction in cyclic adenosine monophosphate (cAMP) signaling, as well as impairments in signaling cascades associated with developmental and immune-inflammatory responses. In vitro experiments showed that AIP deficiency increases intracellular cAMP concentrations in both MEF and murine pituitary adenoma cell lines. Based on knockdown of various G protein α subunits, we concluded that AIP deficiency leads to elevated cAMP concentrations through defective Gαi-2 and Gαi-3 proteins that normally inhibit cAMP synthesis. Furthermore, immunostaining of Gαi-2 revealed that AIP deficiency is associated with a clear reduction in Gαi-2 protein expression levels in human and mouse growth hormone (GH)-secreting pituitary adenomas, thus indicating defective Gαi signaling in these tumors. By contrast, all prolactin-secreting tumors showed prominent Gαi-2 protein levels, irrespective of Aip mutation status. We additionally observed reduced expression of phosphorylated extracellular signal-regulated kinases 1/2 and cAMP response element-binding protein levels in mouse and human AIP-deficient somatotropinomas. This study implies for the first time that a failure to inhibit cAMP synthesis through dysfunctional Gαi signaling underlies the development of GH-secreting pituitary adenomas in AIP mutation carriers.

  1. Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

    PubMed

    Lecoq, Anne-Lise; Zizzari, Philippe; Hage, Mirella; Decourtye, Lyvianne; Adam, Clovis; Viengchareun, Say; Veldhuis, Johannes D; Geoffroy, Valérie; Lombès, Marc; Tolle, Virginie; Guillou, Anne; Karhu, Auli; Kappeler, Laurent; Chanson, Philippe; Kamenický, Peter

    2016-10-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip(+/-)) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of Aip(+/-) mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12 months of age. As the early stages of pituitary tumorigenesis are controversial, we also studied the pituitary histology and somatotroph cell proliferation in these mice. Aip(+/-) mice did not develop gigantism but exhibited a leaner phenotype than wild-type mice. Analysis of GH pulsatility by deconvolution in 12-month-old Aip(+/-) mice showed a mild increase in total GH secretion, a conserved GH pulsatility pattern, but a normal IGF1 concentration. No pituitary adenomas were detected up to 12 months of age. An increased ex vivo response to GHRH of pituitary explants from 3-month-old Aip(+/-) mice, together with areas of enlarged acini identified on reticulin staining in the pituitary of some Aip(+/-) mice, was suggestive of somatotroph hyperplasia. Global heterozygous Aip deficiency in mice is accompanied by subtle increase in GH secretion, which does not result in gigantism. The absence of pituitary adenomas in 12-month-old Aip(+/-) mice in our experimental conditions demonstrates the important phenotypic variability of this congenic mouse model.

  2. Aip regulates cAMP signalling and GH secretion in GH3 cells.

    PubMed

    Formosa, R; Xuereb-Anastasi, A; Vassallo, J

    2013-08-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked to predisposition to pituitary adenomas. However, the mechanism by which this occurs remains unknown. AIP interacts with a number of interesting proteins, including members of the cAMP signalling pathway that has been shown to be consistently altered in pituitary tumours. The functional role of Aip was investigated using both over-expression and knock down of Aip in GH3 cells. cAMP signalling and its downstream effectors, including GH secretion, were then investigated. cAMP signalling was analysed using cAMP assays, cAMP-response element-promoter luciferase reporter assays, real-time PCR and finally secreted GH quantification. Over-expression of wild-type (WT)-Aip reduced forskolin-induced cAMP signalling at the total cAMP level, luciferase reporter activity and target gene expression, when compared with empty vector and the non-functional R304X mutant. Additionally, GH secretion was reduced in WT-Aip over-expressing GH3 cells treated with forskolin. Knock down of endogenous Aip resulted in increased cAMP signalling but a decrease in GH secretion was also noted. Inhibition of phosphodiesterase activity using general and selective inhibitors did not completely ablate the effect of Aip on forskolin-augmented cAMP signalling. A mechanism by which Aip acts as a tumour suppressor, by maintaining a low cAMP signalling and concentration, is suggested. Mutations of Aip render the protein incapable of such activity. This effect appears not to be mediated by the AIP-PDE interaction, suggesting the involvement of other interacting partners in mediating this outcome.

  3. Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations.

    PubMed

    Jaffrain-Rea, Marie-Lise; Rotondi, Sandra; Turchi, Annarita; Occhi, Gianluca; Barlier, Anne; Peverelli, Erika; Rostomyan, Lilya; Defilles, Céline; Angelini, Mariolina; Oliva, Maria-Antonietta; Ceccato, Filippo; Maiorani, Orlando; Daly, Adrian F; Esposito, Vincenzo; Buttarelli, Francesca; Figarella-Branger, Dominique; Giangaspero, Felice; Spada, Anna; Scaroni, Carla; Alesse, Edoardo; Beckers, Albert

    2013-10-01

    Germline aryl hydrocarbon receptor interacting protein (AIP) gene mutations confer a predisposition to pituitary adenoma (PA), predominantly GH-secreting (GH-PA). As recent data suggest a role for AIP in the pathogenesis of sporadic GH-PA and their response to somatostatin analogues (SSA), the expression of AIP and its partner, aryl hydrocarbon receptor (AHR), was determined by semiquantitative immunohistochemistry scoring in 62 sporadic GH-PA (37 treated with SSA preoperatively). The influence of Gsp status was studied in a subset of tumours (n=39, 14 Gsp(+)) and six GH-PA were available for primary cultures. AIP and AHR were detected in most cases, with a positive correlation between AIP and cytoplasmic AHR (P=0.012). Low AIP expression was significantly more frequent in untreated vs SSA-treated tumours (44.0 vs 20.5%, P=0.016). AHR expression or localisation did not differ between the two groups. Similarly, in vitro octreotide induced a median twofold increase in AIP expression (range 1.2-13.9, P=0.027) in GH-PA. In SSA-treated tumours, the AIP score was significantly higher in the presence of preoperative IGF1 decrease or tumour shrinkage (P=0.008 and P=0.014 respectively). In untreated tumours, low AIP expression was significantly associated with invasiveness (P=0.028) and suprasellar extension (P=0.019). The only effect of Gsp status was a significantly lower nuclear AHR score in Gsp(+) vs Gsp(-) tumours (P=0.025), irrespective of SSA. In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.

  4. Governor`s award of excellence for outstanding achievement in waste management. Cape Industries, Wilmington, North Carolina

    SciTech Connect

    1990-12-31

    Cape Industries produces Dimethyl Terephthalate (DMT) and Terephthalic Acid (TA) which are used as raw materials in the production of polyester fibers and films. In this process para-cymene is used as a heat transfer fluid for the process equipment. As the para-cymene is circulated through the process and repeatedly reheated to operating temperatures, some thermal degradation of the cymene and minor contamination due to infiltration of the process material occurs. Prior to August 1988 this spent material was purged from the system and shipped off site for reclamation. The spent material was classified as a hazardous waste due to the characteristic of ignitability. In early 1988 existing equipment was retrofitted allowing for on site distillation of the spent para-cymene in a closed-loop system. Reclaimed para-cymene is returned to the system for reuse while the still bottoms are used as a feedstock in the production of DMT. No waste material is generated.

  5. Aip1 Promotes Actin Filament Severing by Cofilin and Regulates Constriction of the Cytokinetic Contractile Ring*

    PubMed Central

    Chen, Qian; Courtemanche, Naomi; Pollard, Thomas D.

    2015-01-01

    Aip1 (actin interacting protein 1) is ubiquitous in eukaryotic organisms, where it cooperates with cofilin to disassemble actin filaments, but neither its mechanism of action nor its biological functions have been clear. We purified both fission yeast and human Aip1 and investigated their biochemical activities with or without cofilin. Both types of Aip1 bind actin filaments with micromolar affinities and weakly nucleate actin polymerization. Aip1 increases up to 12-fold the rate that high concentrations of yeast or human cofilin sever actin filaments, most likely by competing with cofilin for binding to the side of actin filaments, reducing the occupancy of the filaments by cofilin to a range favorable for severing. Aip1 does not cap the barbed ends of filaments severed by cofilin. Fission yeast lacking Aip1 are viable and assemble cytokinetic contractile rings normally, but rings in these Δaip1 cells accumulate 30% less myosin II. Further, these mutant cells initiate the ingression of cleavage furrows earlier than normal, shortening the stage of cytokinetic ring maturation by 50%. The Δaip1 mutation has negative genetic interactions with deletion mutations of both capping protein subunits and cofilin mutations with severing defects, but no genetic interaction with deletion of coronin. PMID:25451933

  6. Current Concepts and Diagnosis of IgG4-Related Pancreatitis (Type 1 AIP).

    PubMed

    Kawa, Shigeyuki

    2016-08-01

    Although now considered to be a member of the systemic entity of immunoglobulin G4- (IgG4-) related disease, IgG4-related pancreatitis is generally referred to as type 1 autoimmune pancreatitis (AIP). Type 1 AIP was established based on a pathological background of lymphoplasmacytic sclerosing pancreatitis, high serum IgG4 concentration, and abundant IgG4-bearing plasma cell infiltration. The characteristic clinical features of type 1 AIP, such as elderly male preponderance, obstructive jaundice, and mass-forming lesions in the pancreas, often mimic those of pancreatic cancer. However, because AIP responds favorably to corticosteroid treatment, careful differentiation from pancreatic cancer is required. An AIP diagnosis is currently based on the 2011 International Consensus Diagnostic Criteria for AIP, which are based on high sensitivity, selectivity, and accuracy. Over the long term, AIP can progress to a chronic condition, with pancreatic stone formation and atrophy resembling that of chronic pancreatitis. Although AIP has been linked to the complication of malignancies, it remains controversial whether an association exists between the disease and tumor formation.

  7. 75 FR 5846 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... available under Public Law No. 111-117 to accomplish Airport Improvement Program (AIP)-eligible...

  8. 75 FR 3954 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... Program (AIP)-eligible projects that the sponsor previously identified through the Airports Capital... AIP authorization and an extension of the FAA's spending authority from the Airport and Airway...

  9. 76 FR 6178 - Deadline for Notification of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement... under Public Law 111-322 to accomplish Airport Improvement Program (AIP)-eligible projects that the... without a legislative enactment that provides an additional AIP authorization and an extension of the...

  10. AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.

    PubMed

    Lecoq, Anne-Lise; Viengchareun, Say; Hage, Mirella; Bouligand, Jérôme; Young, Jacques; Boutron, Audrey; Zizzari, Philippe; Lombès, Marc; Chanson, Philippe; Kamenický, Peter

    2016-05-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenobiotics implicated in carcinogenesis. As 75% of AIP mutations disrupt the physical and/or functional interaction with AhR, we postulated that the tumorigenic potential of AIP mutations might result from altered AhR signaling. We evaluated the impact of AIP mutations on the AhR signaling pathway, first in fibroblasts from AIP-mutated patients with pituitary adenomas, by comparison with fibroblasts from healthy subjects, then in transfected pituitary GH3 cells. The AIP protein level in mutated fibroblasts was about half of that in cells from healthy subjects, but AhR expression was unaffected. Gene expression analyses showed significant modifications in the expression of the AhR target genes CYP1B1 and AHRR in AIP-mutated fibroblasts, both before and after stimulation with the endogenous AhR ligand kynurenine. Kynurenine increased Cyp1b1 expression to a greater extent in GH3 cells overexpressing wild type compared with cells expressing mutant AIP Knockdown of endogenous Aip in these cells attenuated Cyp1b1 induction by the AhR ligand. Both mutant AIP expression and knockdown of endogenous Aip affected the kynurenine-dependent GH secretion of GH3 cells. This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR transcriptional activity in a gene- and tissue-dependent manner.

  11. Albatross awarded

    NASA Astrophysics Data System (ADS)

    The Albatross Award was presented by the American Miscellaneous Society to Sir George Deacon at the Joint Oceanographic Assembly held in Halifax in August 1982. The presentation speech by Warren Wooster and acceptance speech by Sir George Deacon follow.I have been asked by the governing board of the American Miscellaneous Society to present the Albatross Award this evening. But I hasten to point out that the Board is certainly mythical, and there is even some doubt about the existence of the Society. We know that the American Miscellaneous Society, AMSOC, has had several important committees—the committee to greet visitors from outer space and the committee to teach animals their Latin names, for example—but we know little of their success. On the other hand, the triumphs of AMSOC's Project MOHOLE are al ready inscribed in history.

  12. CFC award

    NASA Image and Video Library

    2012-05-16

    U.S. Navy HT 2 Ryan Vinnedge (right) presents a Combined Federal Campaign award to Stennis Space Center Director Patrick Scheuermann during a May 16, 2012, ceremony. Stennis employees led the way in two categories in the 2011 Southern Mississippi CFC effort, ranking first in the number of Eagle Givers (more than $480 each) and in dollar increase of contributions. Stennis Space Center employees contributed $221,000 through the campaign.

  13. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.

    PubMed

    Ferguson, Annabel A; Springer, Mitchell G; Fisher, Alfred L

    2010-06-01

    Maintenance of a stable, properly folded, and catalytically active proteome is a major challenge to organisms in the face of multiple internal and external stresses which damage proteins and lead to protein misfolding. Here we show that internal metabolic stress produced by reactive intermediates resulting from tyrosine degradation triggers the expression of the aip-1 gene, which is critical in responses to the environmental toxin arsenic and the clearance of unstable polyglutamine and Abeta proteins. aip-1 acts via binding to the proteosome and enhancing proteosomal function. We find that full induction of aip-1 depends on the oxidative-stress-responsive skn-1 transcription factor but significant induction still occurs without skn-1. Importantly, activation of skn-1 with wdr-23(RNAi), which dramatically induces the expression of other skn-1 target genes, produces a minimal increase in aip-1 expression. This suggests that the previously demonstrated specificity in aip-1/AIRAP induction could reflect the actions of multiple synergistic activators, such as the heat shock factor homolog hsf-1, which we also find is required for full induction. These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways.

  14. AIP1 expression in tumor niche suppresses tumor progression and metastasis

    PubMed Central

    Ji, Weidong; Li, Yonghao; He, Yun; Yin, Mingzhu; Zhou, Huanjiao Jenny; Boggon, Titus J.; Zhang, Haifeng; Min, Wang

    2015-01-01

    Studies from tumor cells suggest that tumor suppressor AIP1 inhibits epithelial-mesenchymal transition (EMT). However, the role of AIP1 in the tumor microenvironment has not been examined. We show that a global or vascular endothelial cell (EC)-specific deletion of the AIP1 gene in mice augments tumor growth and metastasis in melanoma and breast cancer models. AIP1-deficient vascular environment not only enhances tumor neovascularization and increases pre-metastatic niche formation, but also secrets tumor EMT-promoting factors. These effects from AIP1 loss are associated with increased VEGFR2 signaling in the vascular EC and could be abrogated by systemic administration of VEGFR2 kinase inhibitors. Mechanistically, AIP1 blocks VEGFR2-dependent signaling by directly binding to the phosphotyrosine residues within the activation loop of VEGFR2. Our data reveal that AIP1, by inhibiting VEGFR2-dependent signaling in tumor niche, suppresses tumor EMT switch, tumor angiogenesis and tumor pre-metastatic niche formation to limit tumor growth and metastasis. PMID:26139244

  15. DOE/Industrial Technologies Program DOE Award Number DE-FG36-05GO15099 Plant Wide Energy Efficiency Assessment Pilgrims Pride Corporation – Mt Pleasant Facility

    SciTech Connect

    Paper, Riyaz; Dooley, Bill; Turpish, William J; Symonds, Mark; Carswell, Needham

    2007-04-13

    The U. S. Department of Energy’s (DOE) Industrial Technologies Program (ITP), through Oak Ridge National Laboratory, is supporting plant wide energy efficiency assessments that will lead to substantial improvements in industrial efficiency, waste reduction, productivity, and global competitiveness in industries identified in ITP’s Industries of the Future. The stated goal of the assessments is to develop a comprehensive strategy at manufacturing locations that will significantly increase plant productivity, profitability, and energy efficiency, and reduce environmental emissions. ITP awarded a contract to Pilgrim’s Pride Corporation to conduct a plant wide energy efficiency assessment for their Mt Pleasant Facility in Mt Pleasant, Texas. Pilgrim’s Pride Corporation is the largest poultry company in the U.S. and Mexico producing nearly 9 billion pounds of poultry per year. Pilgrim's Pride products are sold to foodservice, retail and frozen entrée customers. Pilgrim's Pride owns and operates 37 chicken processing plants (34 in the U.S. and three in Mexico), 12 prepared foods plants and one turkey processing plant. Thirty-five feed mills and 49 hatcheries support these plants. Pilgrim's Pride is ranked number 382 on 2006's FORTUNE 500 list and net sales were $7.4 billion. In Mt. Pleasant, Texas, Pilgrim's Pride operates one of the largest prepared foods plants in the United States, with the capability of producing 2,000 different products and the capacity to turn out more than 7 million pounds of finished goods per week. The facility is divided into distinct departments: East Kill, West Kill, Prepared Foods, Protein Conversion, Wastewater Treatment, and Truck Shop. Facility processes include killing, eviscerating, refrigeration, baking, frying, and protein conversion. Pilgrim’s Pride formed a team to complete the plant wide energy efficiency assessment. The scope of work for this project was to: provide the analysis of departmental energy use, identify

  16. Identification and expression of mutations in the hydroxymethylbilane synthase gene causing acute intermittent porphyria (AIP).

    PubMed Central

    Solis, C.; Lopez-Echaniz, I.; Sefarty-Graneda, D.; Astrin, K. H.; Desnick, R. J.

    1999-01-01

    BACKGROUND: Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme hydroxymethylbilane synthase (EC 4.3.1.8; HMB-synthase). This disease is characterized by acute, life-threatening neurologic attacks that are precipitated by various drugs, hormones, and other factors. The enzymatic and/or biochemical diagnosis of AIP heterozygotes is problematic; therefore, efforts have focused on the identification of HMB-synthase mutations so that heterozygotes can be identified and educated to avoid the precipitating factors. In Spain, the occurrence of AIP has been reported, but the nature of the HMB-synthase mutations causing AIP in Spanish families has not been investigated. Molecular analysis was therefore undertaken in nine unrelated Spanish AIP patients. MATERIALS AND METHODS: Genomic DNA was isolated from affected probands and family members of nine unrelated Spanish families with AIP. The HMB-synthase gene was amplified by long-range PCR and the nucleotide sequence of each exon was determined by cycle sequencing. RESULTS: Three new mutations, a missense, M212V; a single base insertion, g4715insT; and a deletion/insertion, g7902ACT-->G, as well as five previously reported mutations (G111R, R116W, R149X R167W, and R173W) were detected in the Spanish probands. Expression of the novel missense mutation M212V in E. coli revealed that the mutation was causative, having <2% residual activity. CONCLUSIONS: These studies identified the first mutations in the HMB-synthase gene causing AIP in Spanish patients. Three of the mutations were novel, while five previously reported lesions were found in six Spanish families. These findings enable accurate identification and counseling of presymptomatic carriers in these nine unrelated Spanish AIP families and further demonstrate the genetic heterogeneity of mutations causing AIP. Images Fig. 1 PMID:10602775

  17. Vehicle Technologies Program Awards and Patents

    SciTech Connect

    2011-12-13

    Award-winning technologies and processes are hallmarks of the programs funded by the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, and industrial partners. Awards, patents, and other recognition validate the products of research undertaken as part of the Vehicle Technologies Program.

  18. Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Daly, Adrian F; Beckers, Albert

    2015-03-01

    The most frequent conditions that are associated with inherited/familial pituitary adenomas are familial isolated pituitary adenoma (FIPA) and multiple endocrine neoplasia type 1 (MEN1), which together account for up to 5% of pituitary adenomas. One important genetic cause of FIPA are inactivating mutations or deletions in the aryl hydrocarbon receptor interacting protein (AIP) gene. FIPA is the most frequent clinical presentation of AIP mutations. This article traces the current state of knowledge regarding the clinical features of FIPA and the particular genetic, pathologic, and clinical characteristics of pituitary adenomas due to AIP mutations.

  19. AWARD program

    NASA Astrophysics Data System (ADS)

    Leppert, Frank

    1998-07-01

    The All Weather ARrival and Departure (AWARD) program is supported by the European Commission under the Brite-EuRam III structure. Following the VERSATILE preparation program, it started on June 1996 and is planned to finish end of 1999. The program consortium consists of ten partners such as a major airline, aircraft and equipment manufacturers, research and tests centers, and an university. Contractors from France, Germany, Great Britain, Italy and The Netherlands are coordinated by Sextant Avionique. AWARD main objective is to demonstrate the efficiency of vision systems under adverse weather conditions. In order to evaluate the added benefits of these concepts within aircraft operations of approach, landing, taxi and takeoff, two applications are developed: (1) Enhanced Vision System (EVS) based on Head Up Display enhancement with Forward Looking Infrared (FLIR) and Millimeter Wave Radar (MMWR) images. (2) Synthetic Vision System (SVS) displaying an overlaid symbology on a perspective presentation of the environment, thanks to the combination of database and accurate positioning systems. The evaluation of these two tests systems will focus on: (1) Performance and human acceptability aspects. They will be appreciated according to human factors criteria as well as an integration within realistic environments. The NLR Research Flight Simulator and the DLR ATTAS flight test aircraft will be used. (2) Reliability, integrity aspects thanks to a theoretical certification/system study which will propose guidelines for certification, and will address impact on the system architecture. The paper addresses the work structure of AWARD in order to show what are the keypoints addressed in this program.

  20. Presidential Green Chemistry Challenge: 2002 Academic Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2002 award winner, Professor Eric J. Beckman, developed fluorine-free detergents that help supercritical carbon dioxide (CO2) dissolve many chemicals, so it can be a solvent for industrial processes.

  1. Presidential Green Chemistry Challenge: 1996 Academic Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 1996 award winner, Professor Mark Holtzapple, developed methods to convert waste biomass (e.g., sewage sludge, agricultural wastes), into animal feed, industrial chemicals, or fuels.

  2. 77 FR 51948 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... Federal Aviation Administration 14 CFR Chapter 1 Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property; Correction AGENCY: Federal Aviation Administration (FAA... paragraph in the Proposed Policy Regarding Access to Airports From Residential Property that was...

  3. Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours.

    PubMed

    Magnusson, Linda; Hansen, Nils; Saba, Karim H; Nilsson, Jenny; Fioretos, Thoas; Rissler, Pehr; Nord, Karolin H

    2017-10-01

    Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  4. Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening.

    PubMed

    Pinho, Leandro Kasuki Jomori de; Vieira Neto, Leonardo; Wildemberg, Luiz Eduardo Armondi; Moraes, Aline Barbosa; Takiya, Christina M; Frohman, Lawrence A; Korbonits, Márta; Gadelha, Mônica R

    2010-11-01

    We present four FIPA kindred discussing clinical and molecular data and emphasizing the differences regarding AIP status, as well as the importance of genetic screening. Family 1 consists of five patients harboring somatotropinomas with germline E24X mutation in AIP. In one of the patients, acromegaly was diagnosed through active screening, being cured by surgery. Families 2 and 3 are composed of two patients with non-functioning pituitary adenomas. Family 4 comprises patients harboring a prolactinoma and a somatotropinoma. No mutations in AIP were found in these families. No patient in Family 1 was controlled with octreotide treatment, while the acromegalic patient in Family 4 was controlled with octreotide LAR. In conclusion, FIPA is a heterogeneous condition, which may be associated with AIP mutation. Genomic and clinical screening is recommended in families with two or more members harboring pituitary adenomas, allowing early diagnosis and better outcome.

  5. Importance of Abdominal Ultrasound in 17 Patients with Histologically Confirmed Autoimmune Pancreatitis (AIP).

    PubMed

    Mauch, M; Blank, W; Kunze, G; Dirks, K; Schuler, A; Klinggräff von, G; Seitz, K

    2015-06-01

    Autoimmune pancreatitis (AIP) is an independent, underdiagnosed, rare form of chronic pancreatitis. The goal of this study is to document ultrasound findings in histologically confirmed AIP in order to determine the diagnostic value of ultrasound. 6 of 74 DEGUM instructors for internal medicine (level 3 and 2) provided anonymized clinical and sonographic data from 17 patients with histologically confirmed AIP. 9/17 patients had diffuse AIP, 8/17 had focal AIP, 14/17 suffered from upper abdominal pain, 9/17 had jaundice, and 3/9 had an elevated IgG4 level. Ultrasound showed diffuse hypoechoic organ enlargement in 9/17 cases and a hypoechoic tumor with an unclear border in 8/17 cases. AIP was verified by ultrasound-guided percutaneous core biopsy in 14 cases, by biopsy of the bile duct in 1 case, and by surgical biopsy in 2 cases. Involvement of the hepatobiliary system was present in 7/17 patients and autoimmune cholangitis was verified in 5 cases. All patients experienced remission after immunosuppressive treatment. The pancreatic duct had a normal width in 11 cases, was dilated in 5 cases, and was stenosed over a long stretch in 3 cases. Contrast-enhanced ultrasound did not show uniform signal increase but also no significantly reduced or absent perfusion. Ultrasound can be diagnostically useful if the clinical manifestations of AIP are known. While the diffuse form allows an ad-hoc suspected diagnosis, the focal form can only be suspected in the case of additional extrapancreatic involvement. Contrast-enhanced ultrasound (CEUS) contributes greatly to the differentiation from ductal adenocarcinoma in the case of focal AIP. © Georg Thieme Verlag KG Stuttgart · New York.

  6. The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.

    PubMed

    Heliövaara, Elina; Raitila, Anniina; Launonen, Virpi; Paetau, Anders; Arola, Johanna; Lehtonen, Heli; Sane, Timo; Weil, Robert J; Vierimaa, Outi; Salmela, Pasi; Tuppurainen, Karoliina; Mäkinen, Markus; Aaltonen, Lauri A; Karhu, Auli

    2009-12-01

    Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to the development of pituitary adenomas. Here, we characterized AIP mutation positive (AIPmut+) and AIP mutation negative (AIPmut-) pituitary adenomas by immunohistochemistry. The expressions of the AIP-related proteins aryl hydrocarbon receptor (AHR), AHR nuclear translocator (ARNT), cyclin-dependent kinase inhibitor 1B encoding p27(Kip1), and hypoxia-inducible factor 1-alpha were examined in 14 AIPmut+ and 53 AIPmut- pituitary adenomas to detect possible expression differences. In addition, the expression of CD34, an endothelial and hematopoietic stem cell marker, was analyzed. We found ARNT to be less frequently expressed in AIPmut+ pituitary adenomas (P = 0.001), suggesting that AIP regulates the ARNT levels. AIP small interfering RNA-treated HeLa, HEK293, or Aip-null mouse embryonic fibroblast cells did not show lowered expression of ARNT. Instead, in the pituitary adenoma cell line GH3, Aip silencing caused a partial reduction of Arnt and a clear increase in cell proliferation. We also observed a trend for increased expression of nuclear AHR in AIPmut+ samples, although the difference was not statistically significant (P = 0.06). The expressions of p27(Kip1), hypoxia-inducible factor 1-alpha, or CD34 did not differ between tumor types. The present study shows that the expression of ARNT protein is significantly reduced in AIPmut+ tumors. We suggest that the down-regulation of ARNT may be connected to an imbalance in AHR/ARNT complex formation arising from aberrant cAMP signaling.

  7. cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.

    PubMed

    Bolger, Graeme B; Bizzi, Mariana F; Pinheiro, Sergio V; Trivellin, Giampaolo; Smoot, Lisa; Accavitti, Mary-Ann; Korbonits, Márta; Ribeiro-Oliveira, Antonio

    2016-05-01

    PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore regulate numerous processes, including cell growth and differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations in AIP occur in approximately 20% of patients with Familial Isolated Pituitary Adenoma (FIPA) and 20% of childhood-onset simplex somatotroph adenomas. We therefore examined the protein expression of PDE4A4 and the closely related isoform PDE4A8 in normal human pituitary tissue and in pituitary adenomas. PDE4A4 had low expression in normal pituitary but was significantly overexpressed in somatotroph, lactotroph, corticotroph and clinically nonfunctioning gonadotroph adenomas (P<0.0001 for all subtypes). Likewise, PDE4A8 was expressed in normal pituitary and was also significantly overexpressed in the adenoma subtypes (P<0.0001 for all). Among the different adenoma subtypes, corticotroph and lactotroph adenomas were the highest and lowest expressed for PDE4A4, respectively, whereas the opposite was observed for PDE4A8. Naturally occurring oncogenic variants in AIP were shown by a two-hybrid assay to disrupt the ability of AIP to interact with PDE4A5. A reverse two-hybrid screen identified numerous additional variants in the tetratricopeptide repeat (TPR) region of AIP that also disrupted its ability to interact with PDE4A5. The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.

  8. AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.

    PubMed

    Fumoto, K; Lee, P-C; Saya, H; Kikuchi, A

    2008-07-24

    Glycogen synthase kinase-3 (GSK-3beta) regulates microtubule dynamics and cellular polarity through phosphorylating various microtubule associating proteins and plus-end tracking proteins. Although it was also reported that GSK-3beta is inactivated by protein kinase B at the spindle poles, functions and targets of GSK-3beta in the mitotic phase are unknown. Here, we identified Aurora-A-interacting protein (AIP), a negative regulator of Aurora-A, as a binding partner of GSK-3beta. AIP was colocalized with Aurora-A and GSK-3beta to the spindle poles in metaphase, and its depletion in cells stabilized and activated Aurora-A in early mitotic phase and caused mitotic cell arrest. Treatment of the cells with a GSK-3beta inhibitor reduced the protein level of Aurora-A and this reduction was suppressed by AIP knockdown. AIP was phosphorylated by GSK-3beta, and an AIP mutant in which the GSK-3beta phosphorylation site was mutated could bind and downregulate Aurora-A more efficiently. These results suggest that GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.

  9. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

    PubMed

    Johnson, Jeffrey G; Wang, Boyuan; Debelouchina, Galia T; Novick, Richard P; Muir, Tom W

    2015-05-04

    The agr locus in the commensal human pathogen, Staphylococcus aureus, is a two-promoter regulon with allelic variability that produces a quorum-sensing circuit involved in regulating virulence within the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentrations by AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global changes in gene expression. The finding that staphylococcal virulence can be inhibited through antagonism of this quorum-sensing pathway has fueled tremendous interest in understanding the structure-activity relationships underlying the AIP-AgrC interaction. The defining structural feature of the AIP is a 16-membered, thiolactone-containing macrocycle. Surprisingly, the importance of ring size on agr activation or inhibition has not been explored. In this study, we address this deficiency through the synthesis and functional analysis of AIP analogues featuring enlarged and reduced macrocycles. Notably, this study is the first to interrogate AIP function by using both established cell-based reporter gene assays and newly developed in vitro AgrC-I binding and autophosphorylation activity assays. Based on our data, we present a model for robust agr activation involving a cooperative, three-points-of-contact interaction between the AIP macrocycle and AgrC.

  10. Children's Book Awards Annual 1998.

    ERIC Educational Resources Information Center

    Berman, Matt; Dupuy, Marigny J.

    This publication reviews the books from the major national children's book awards and lists. The following awards are covered: John Newberry Awards, Randolph Caldecott Awards, Coretta Scott King Awards, Mildred L. Batchelder Awards, Pura Belpre, Boston Globe-Horn Book Award, and the National Book Award for Young People's Literature. The lists are…

  11. Acute interstitial pneumonia (AIP): relationship to Hamman-Rich syndrome, diffuse alveolar damage (DAD), and acute respiratory distress syndrome (ARDS).

    PubMed

    Mukhopadhyay, Sanjay; Parambil, Joseph G

    2012-10-01

    Acute interstitial pneumonia (AIP) is a term used for an idiopathic form of acute lung injury characterized clinically by acute respiratory failure with bilateral lung infiltrates and histologically by diffuse alveolar damage (DAD), a combination of findings previously known as the Hamman-Rich syndrome. This review aims to clarify the diagnostic criteria of AIP, its relationship with DAD and acute respiratory distress syndrome (ARDS), key etiologies that need to be excluded before making the diagnosis, and the salient clinical features. Cases that meet clinical and pathologic criteria for AIP overlap substantially with those that fulfill clinical criteria for ARDS. The main differences between AIP and ARDS are that AIP requires a histologic diagnosis of DAD and exclusion of known etiologies. AIP should also be distinguished from "acute exacerbation of IPF," a condition in which acute lung injury (usually DAD) supervenes on underlying usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF).

  12. Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study.

    PubMed

    Ferraù, Francesco; Romeo, P D; Puglisi, S; Ragonese, M; Torre, M L; Scaroni, C; Occhi, G; De Menis, E; Arnaldi, G; Trimarchi, F; Cannavò, S

    2016-12-01

    This multicentric study aimed to investigate the prevalence of the G protein-coupled receptor 101 (GPR101) p.E308D variant and aryl hydrocarbon receptor interacting protein (AIP) gene mutations in a representative cohort of Italian patients with acromegaly. 215 patients with GH-secreting pituitary adenomas, referred to 4 Italian referral centres for pituitary diseases, have been included. Three cases of gigantism were present. Five cases were classified as FIPA. All the patients have been screened for germline AIP gene mutations and GPR101 gene p.E308D variant. Heterozygous AIP gene variants have been found in 7 patients (3.2 %). Five patients carried an AIP mutation (2.3 %; 4 females): 3 patients harboured the p.R3O4Q mutation, one had the p.R304* mutation and the last one the IVS3+1G>A mutation. The prevalence of AIP mutations was 3.3 % and 2.8 % when considering only the patients diagnosed when they were <30 or <40-year old, respectively. Furthermore, 2.0 % of the patients with a pituitary macroadenoma and 4.2 % of patients resistant to somatostatin analogues treatment were found to harbour an AIP gene mutation. None of the patients was found to carry the GPR101 p.E308D variant. The prevalence of AIP gene mutations among our sporadic and familial acromegaly cases was similar to that one reported in previous studies, but lower when considering only the cases diagnosed before 40 years of age. The GPR101 p.E308D change is unlikely to have a role in somatotroph adenomas tumorigenesis, since none of our sporadic or familial patients tested positive for this variant.

  13. A novel germline mutation in the aryl hydrocarbon receptor-interacting protein (AIP) gene in an Italian family with gigantism.

    PubMed

    Urbani, C; Russo, D; Raggi, F; Lombardi, M; Sardella, C; Scattina, I; Lupi, I; Manetti, L; Tomisti, L; Marcocci, C; Martino, E; Bogazzi, F

    2014-10-01

    Acromegaly usually occurs as a sporadic disease, but it may be a part of familial pituitary tumor syndromes in rare cases. Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been associated with a predisposition to familial isolated pituitary adenoma. The aim of the present study was to evaluate the AIP gene in a patient with gigantism and in her relatives. Direct sequencing of AIP gene was performed in fourteen members of the family, spanning among three generations. The index case was an 18-year-old woman with gigantism due to an invasive GH-secreting pituitary adenoma and a concomitant tall-cell variant of papillary thyroid carcinoma. A novel germline mutation in the AIP gene (c.685C>T, p.Q229X) was identified in the proband and in two members of her family, who did not present clinical features of acromegaly or other pituitary disorders. Eleven subjects had no mutation in the AIP gene. Two members of the family with clinical features of acromegaly refused either the genetic or the biochemical evaluation. The Q229X mutation was predicted to generate a truncated AIP protein, lacking the last two tetratricopeptide repeat domains and the final C-terminal α-7 helix. We identified a new AIP germline mutation predicted to produce a truncated AIP protein, lacking its biological properties due to the disruption of the C-terminus binding sites for both the chaperones and the client proteins of AIP.

  14. [AIP mutations in familial and sporadic pituitary adenomas: local experience and review of the literature].

    PubMed

    Fajardo-Montañana, Carmen; Daly, Adrian F; Riesgo-Suárez, Pedro; Gómez-Vela, José; Tichomirowa, María A; Camara-Gómez, Rosa; Beckers, Albert

    2009-01-01

    Clinically relevant pituitary adenomas occur 3-5 times more frequently than previously thought. The majority are isolated cases, but their presentation can be familial in the setting of known syndromes such as multiple endocrine neoplasia (MEN)-1 and Carney complex. When 2 or more cases of pituitary adenomas occur in the same family in the absence of the above-mentioned syndromes, a diagnosis of FIPA (familial isolated pituitary adenomas) is made, which accounts for 1-2% of all pituitary adenomas. Mutations of the gene AIP (aryl hydrocarbon receptor-interacting protein) may account for 15% of FIPA families (50% of familial acromegaly), and as such the genetic causes continue to be studied. Also mutations in AIP can be detected in sporadic adenomas among young populations (< 30 years of age). We describe the characteristics of FIPA, detailing the study of a spanish family, in this case AIP mutation negative. Also, the reported findings in sporadic adenomas in the young population are detailed, accompanied by the description of a 19- year old patient with an intronic AIP mutation. Multicenter studies have provided understanding of aspects such as mutations in AIP; however, further studies are necessary to identify other genes involved in FIPA and sporadic pituitary adenomas occurring at a young age.

  15. Sustainable Management of Seagrass Meadows: the GEOSS AIP-6 Pilot

    NASA Astrophysics Data System (ADS)

    Santoro, Mattia; Pastres, Roberto; Zucchetta, Matteo; Venier, Chiara; Roncella, Roberto; Bigagli, Lorenzo; Mangin, Antoine; Amine Taji, Mohamed; Gonzalo Malvarez, Gonzalo; Nativi, Stefano

    2014-05-01

    Seagrass meadows (marine angiosperm plants) occupy less than 0.2% of the global ocean surface, annually store about 10-18% of the so-called "Blue Carbon", i.e. the Carbon stored in coastal vegetated areas. Recent literature estimates that the flux to the long-term carbon sink in seagrasses represents 10-20% of seagrasses global average production. Such figures can be translated into economic benefits, taking into account that a ton of carbon dioxide in Europe is paid at around 15 € in the carbon market. This means that the organic carbon retained in seagrass sediments in the Mediterranean is worth 138 - 1128 billion €, which represents 6-23 € per square meter. This is 9-35 times more than one square meter of tropical forest soil (0.66 € per square meter), or 5-17 times when considering both the above and the belowground compartments in tropical forests. According the most conservative estimations, about 10% of the Mediterranean meadows have been lost during the last century. To estimate seagrass meadows distribution, a Species Distribution Model (SDM) can be used. SDM is a tool that is used to evaluate the potential distribution of a given species (e.g. Posidonia oceanica for seagrass) on the basis of the features (bio-chemical-physical parameters) of the studied environment. In the framework of the GEOSS (Global Earth Observation System of Systems) initiative, the FP7 project MEDINA developed a showcase as part of the GEOSS Architecture Interoperability Pilot - phase 6 (AIP-6). The showcase aims at providing a tool for the sustainable management of seagrass meadows along the Mediterranean coastline by integrating the SDM with available GEOSS resources. This way, the required input data can be searched, accessed and ingested into the model leveraging the brokering framework of the GEOSS Common Infrastructure (GCI). This framework is comprised of a set of middle-ware components (Brokers) that are in charge of implementing the needed interoperability

  16. Intracellular Trafficking of AIP56, an NF-κB-Cleaving Toxin from Photobacterium damselae subsp. piscicida

    PubMed Central

    Pereira, Liliana M. G.; Pinto, Rute D.; Silva, Daniela S.; Moreira, Ana R.; Beitzinger, Christoph; Oliveira, Pedro; Sampaio, Paula; Benz, Roland; Azevedo, Jorge E.; dos Santos, Nuno M. S.

    2014-01-01

    AIP56 (apoptosis-inducing protein of 56 kDa) is a metalloprotease AB toxin secreted by Photobacterium damselae subsp. piscicida that acts by cleaving NF-κB. During infection, AIP56 spreads systemically and depletes phagocytes by postapoptotic secondary necrosis, impairing the host phagocytic defense and contributing to the genesis of infection-associated necrotic lesions. Here we show that mouse bone marrow-derived macrophages (mBMDM) intoxicated by AIP56 undergo NF-κB p65 depletion and apoptosis. Similarly to what was reported for sea bass phagocytes, intoxication of mBMDM involves interaction of AIP56 C-terminal region with cell surface components, suggesting the existence of a conserved receptor. Biochemical approaches and confocal microscopy revealed that AIP56 undergoes clathrin-dependent endocytosis, reaches early endosomes, and follows the recycling pathway. Translocation of AIP56 into the cytosol requires endosome acidification, and an acidic pulse triggers translocation of cell surface-bound AIP56 into the cytosol. Accordingly, at acidic pH, AIP56 becomes more hydrophobic, interacting with artificial lipid bilayer membranes. Altogether, these data indicate that AIP56 is a short-trip toxin that reaches the cytosol using an acidic-pH-dependent mechanism, probably from early endosomes. Usually, for short-trip AB toxins, a minor pool reaches the cytosol by translocating from endosomes, whereas the rest is routed to lysosomes for degradation. Here we demonstrate that part of endocytosed AIP56 is recycled back and released extracellularly through a mechanism requiring phosphoinositide 3-kinase (PI3K) activity but independent of endosome acidification. So far, we have been unable to detect biological activity of recycled AIP56, thereby bringing into question its biological relevance as well as the importance of the recycling pathway. PMID:25287919

  17. Design, construction and test of mercury thermometric cell in CENAMEP AIP

    NASA Astrophysics Data System (ADS)

    Ortega-Cortés, R.; Méndez-Lango, E.; Araolaza-Rodriguez, A.

    2013-09-01

    We present the results of the design, construction, filling and test of thermometric cell, to reproduce the triple point of mercury in the Temperature Laboratory of Centro Nacional de Metrología de Panamá AIP (CENAMEP AIP). This cell will be included in the group of thermometric cells of the laboratory. With this cell CENAMEP-AIP is covering the -39 °C to 660 °C range. This new cell offers the opportunity to reproduce the primary temperature defined by ITS-90 of -38.8344 ° C, and was built with 0.68 kg of mercury ultra-pure certified by the National Institute of Standards and Technology from United States (NIST-EEUU). The reproducibility obtained with thermometric cell of mercury is approximately one thousandth of kelvin (1 mK). This value satisfies according to current laboratory equipment.

  18. Quality Improvement Awards and Vocational Education Assessment. ERIC Digest No. 182.

    ERIC Educational Resources Information Center

    Brown, Bettina Lankard

    Quality system awards offer blueprints for assessing quality in vocational education as well as in business and industry. The three most prestigious awards recognizing quality improvement in business and industry are the Malcolm Baldrige Quality Award, Deming Application Prize, and ISO 9000 Registration. When comparing standards for the quality…

  19. 28 CFR 345.74 - Awards for special achievements for inmate workers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Awards for special achievements for inmate workers. 345.74 Section 345.74 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.74 Awards for...

  20. 28 CFR 345.74 - Awards for special achievements for inmate workers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Awards for special achievements for inmate workers. 345.74 Section 345.74 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.74 Awards for...

  1. 28 CFR 345.74 - Awards for special achievements for inmate workers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Awards for special achievements for inmate workers. 345.74 Section 345.74 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.74 Awards for...

  2. 28 CFR 345.74 - Awards for special achievements for inmate workers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Awards for special achievements for inmate workers. 345.74 Section 345.74 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.74 Awards for...

  3. 28 CFR 345.74 - Awards for special achievements for inmate workers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Awards for special achievements for inmate workers. 345.74 Section 345.74 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.74 Awards for...

  4. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

    PubMed Central

    Zhang, Haifeng; He, Yun; Dai, Shengchuan; Xu, Zhe; Luo, Yan; Wan, Ting; Luo, Dianhong; Jones, Dennis; Tang, Shibo; Chen, Hong; Sessa, William C.; Min, Wang

    2008-01-01

    ASK1-interacting protein-1 (AIP1), a recently identified member of the Ras GTPase-activating protein family, is highly expressed in vascular ECs and regulates EC apoptosis in vitro. However, its function in vivo has not been established. To study this, we generated AIP1-deficient mice (KO mice). Although these mice showed no obvious defects in vascular development, they exhibited dramatically enhanced angiogenesis in 2 models of inflammatory angiogenesis. In one of these models, the enhanced angiogenesis observed in the KO mice was associated with increased VEGF-VEGFR2 signaling. Consistent with this, VEGF-induced ear, cornea, and retina neovascularization were greatly augmented in KO mice and the enhanced retinal angiogenesis was markedly diminished by overexpression of AIP1. In vitro, VEGF-induced EC migration was inhibited by AIP1 overexpression, whereas it was augmented by both AIP1 knockout and knockdown, with the enhanced EC migration caused by AIP1 knockdown being associated with increased VEGFR2 signaling. We present mechanistic data that suggest AIP1 is recruited to the VEGFR2-PI3K complex, binding to both VEGFR2 and PI3K p85, at a late phase of the VEGF response, and that this leads to inhibition of VEGFR2 signaling. Taken together, our data demonstrate that AIP1 functions as an endogenous inhibitor in VEGFR2-mediated adaptive angiogenesis in mice. PMID:19033661

  5. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene.

    PubMed

    Rowlands, J Craig; Urban, Jonathan D; Wikoff, Daniele Staskal; Budinsky, Robert A

    2011-01-01

    The human aryl hydrocarbon receptor (AHR) is a protein for which there is little evidence of polymorphic variability of functional consequence. It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP). There are limited data on AIP single nucleotide polymorphisms (SNPs) with potential functional consequences. We sequenced 103 human DNA samples within the open reading frames of the AIP locus using samples from six ethnic populations to further characterize AIP SNPs. Eight exonic SNPs were identified at the AIP locus, including three novel SNPs: T48T, L212L, and V302V. Combined with prior reports, there are now a total of 14 exonic SNPs that have been identified within AIP. Of these, six are non-synonymous and are therefore of potential functional importance, though only two of these (Q228K and A276V) were detected in the current study. The functional consequences of Q228K and A276V are unknown, although functional evidence from AIP SNPs associated with congenital pituitary tumors suggests that such amino acid changes are likely to have no effect or to decrease, rather than increase, sensitivity to dioxins. To date, no non-synonymous SNPs have been detected in the AHR-binding region of AIP.

  6. Should aip gene screening be recommended in family members of FIPA patients with R16H variant?

    PubMed

    Zatelli, Maria Chiara; Torre, Maria Luisa; Rossi, Rachele; Ragonese, Marta; Trimarchi, Francesco; degli Uberti, Ettore; Cannavò, Salvatore

    2013-06-01

    Germline mutations of aryl-hydrocarbon-receptor interacting protein (AIP) are associated with pituitary adenoma predisposition. They occur in 20 % of familial isolated pituitary adenoma (FIPA) and in about 3-5 % of sporadic pituitary adenomas, especially in early onset somatotropinomas and prolactinomas. Our aim was to evaluate the clinical and genetic features of a large Italian FIPA family, where an AIP variant was identified. AIP direct sequencing from genomic DNA was carried out in 16 available family members. AIP R16H carriers also underwent magnetic resonance imaging and hormonal assessments. AIP mutations were also searched in 16 patients with sporadic growth hormone-secreting pituitary adenoma and in 6 unrelated patients in whom pituitary adenoma was excluded. We found an AIP R16H variation in two family members harbouring a pituitary adenoma and in 6 unaffected family members. No AIP mutation was found neither in growth hormone-secreting pituitary adenoma patients, nor in the unrelated patients without pituitary adenoma. We report a FIPA family harbouring an AIP R16H change, supporting the hypothesis that the latter represents a variant of unknown significance.

  7. [The change of atherogenic index of plasma (AIP) level in type 2 diabetic pedigrees and the response of AIP to Acarbose or Glimepiride in therapy of type 2 diabetes mellitus].

    PubMed

    Yang, Bo; Tian, Haoming; Ren, Yan; Tong, Nanwei; Yu, Hongling; Han, Lingchuan; Ran, Xingwu

    2005-06-01

    The alterations in atherogenic index of plasma (AlP) in type 2 diabetic patients and their normoglycemic first-degree relatives (NFDR) were investigated, and the effects of Acarbose or Glimepiride on AIP in 99 type 2 diabetic patients were evaluated. Triglycerride (TG), total cholesterol, high density lipoprotein-cholesterol (HDL-C) levels were analyzed, and Log (TG/HDL-C) was calculated as AIP in 62 type 2 diabetic patients and their 67 NFDR from 29 type 2 diabetic pedigrees and in 45 healthy controls without family histories of diabetes. Also analyzed were the same parameters in 99 type 2 diabetic patients before and after therapy with Acarbose or Glimepiride. The results revealed that diabetic patients and their NFDR had significantly higher AIP than did the controls, whereas no significant differences were seen between diabetic patients and their NFDR. Positive correlation of AIP between type 2 diabetic patients and their offspring were observed (r = 0.241, P < 0.05). After 8 weeks therapy with Acarbose, the AIP of type 2 diabetic patients was decreased significantly, and no differences were observed for AIP levels in Glimepiride group although the AIP was lower when compared with the untreated level. As a significant inverse correlation of small dense low density lipoprotein (sdLDL) with AIP was confirmed, our data suggest that diabetic patients and their NFDR from type 2 diabetic pedigrees had significantly higher AIP than did controls; AIP could be decreased by therapy with Acarbose in type 2 diabetic patients; Glimepiride may bring potential benefit to type 2 diabetic patients by influencing sdLDL.

  8. Hutchinson Award to Schindler

    NASA Astrophysics Data System (ADS)

    O'Brien, W. John

    David William Schindler is the 1985 recipient of the Hutchinson Award, given annually by the American Society of Limnology and Oceanography. It is awarded to an active scientist in limnology and oceanography in recognition for outstanding research.

  9. NWWA Science Award given

    NASA Astrophysics Data System (ADS)

    Back, Bill

    John G. Ferris, a U.S. Geological Survey retiree, received the National Water Well Association (NWWA) Science Award for 1985 on September 10, 1985, in Baltimore, Md. The award recognizes Ferris's renowned contributions to the science of groundwater.

  10. Alley receives Horton Award

    NASA Astrophysics Data System (ADS)

    Alley, Richard B.

    Richard B. Alley was awarded the Hydrology section's Horton Award on December 16, 1996, at the AGU Fall Meeting in San Francisco. The Horton Award recognizes a single outstanding contribution to the science of hydrology made during the preceding 5 years.

  11. Hancock County Awards Gala

    NASA Image and Video Library

    2008-08-26

    Gene Goldman (left), deputy director of NASA's John C. Stennis Space Center, accepts an Award of Excellence from Jack Zink, executive director of the Hancock County Port and Harbor Commission, during the 2008 Annual Hancock County Awards Gala. The Award of Excellence was presented to recognize Stennis Space Center's contribution to NASA's 50 years of excellence in space exploration.

  12. The John Muir Award.

    ERIC Educational Resources Information Center

    White, Graham

    2002-01-01

    The John Muir Award was established in the United Kingdom to respond to minimal environmental awareness, especially among youth. The Award has three levels of effort; all involve discovering a wild place, exploring its wildness, helping to conserve it, and sharing the experience with a wider audience. There is an effort to establish the award in…

  13. Hancock County Awards Gala

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Gene Goldman (left), deputy director of NASA's John C. Stennis Space Center, accepts an Award of Excellence from Jack Zink, executive director of the Hancock County Port and Harbor Commission, during the 2008 Annual Hancock County Awards Gala. The Award of Excellence was presented to recognize Stennis Space Center's contribution to NASA's 50 years of excellence in space exploration.

  14. AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3

    PubMed Central

    Zhang, Rong; He, Xiangrong; Liu, Weimin; Lu, Meng; Hsieh, Jer-Tsong; Min, Wang

    2003-01-01

    TNF-α activates ASK1 in part by dissociating 14-3-3 from apoptosis signal–regulating kinase 1 (ASK1). In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-interacting protein (AIP1). AIP1 binds to the C-terminal domain of ASK1 via a lysine-rich cluster within the N-terminal C2 domain. AIP1 exists in a closed form through an intramolecular interaction between the N-terminus and the C-terminus, and TNF-α induces unfolding of AIP1 leading to association of AIP1 with ASK1. Thus, the N-terminus of AIP1 containing the C2 and GAP domains constitutively binds to ASK1 and facilitates the release of 14-3-3 from ASK1. In contrast to 14-3-3, AIP1 binds preferentially to dephosphorylated ASK1. Recruited AIP1 enhances ASK1-induced JNK activation, and the ASK1 binding and the GAP activity of AIP1 are critical for AIP1-enhanced ASK1 activation. Furthermore, TNF-induced ASK1/JNK activation is significantly blunted in cells where AIP1 is knocked down by RNA interference. These data suggest that AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of inhibitor 14-3-3 from ASK1, a novel mechanism by which TNF-α activates ASK1. PMID:12813029

  15. School Board Improvement Plans in Relation to the AIP Model of Educational Accountability: A Content Analysis

    ERIC Educational Resources Information Center

    van Barneveld, Christina; Stienstra, Wendy; Stewart, Sandra

    2006-01-01

    For this study we analyzed the content of school board improvement plans in relation to the Achievement-Indicators-Policy (AIP) model of educational accountability (Nagy, Demeris, & van Barneveld, 2000). We identified areas of congruence and incongruence between the plans and the model. Results suggested that the content of the improvement…

  16. 78 FR 42419 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... unclear and has clarified this language in the Compliance Guidance Letter. In most cases of establishing... extend its existing access, is linked to an AIP funding decision. The language in section II of the Final... reading of the language. The provision is narrowly drafted to apply to ``general aviation airports'' only...

  17. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity

    PubMed Central

    Kiefer, Christian S.; Claes, Andrea R.; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity. PMID:25428588

  18. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    PubMed

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.

  19. 75 FR 57829 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Federal Aviation Administration Airport Improvement Program (AIP): Policy Regarding Access to Airports... Proposed Policy Regarding Access to Airports From Residential Property that was published in the Federal... and clarify FAA policy concerning through-the-fence access to a Federally obligated airport from...

  20. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1

    PubMed Central

    Costa, Luciana J; Chen, Nan; Lopes, Adriana; Aguiar, Renato S; Tanuri, Amilcar; Plemenitas, Ana; Peterlin, B Matija

    2006-01-01

    Background Nef is an accessory protein of primate lentiviruses, HIV-1, HIV-2 and SIV. Besides removing CD4 and MHC class I from the surface and activating cellular signaling cascades, Nef also binds GagPol during late stages of the viral replicative cycle. In this report, we investigated further the ability of Nef to facilitate the replication of HIV-1. Results To this end, first the release of new viral particles was much lower in the absence of Nef in a T cell line. Since the same results were obtained in the absence of the viral envelope using pseudo-typed viruses, this phenomenon was independent of CD4 and enhanced infectivity. Next, we found that Nef not only possesses a consensus motif for but also binds AIP1 in vitro and in vivo. AIP1 is the critical intermediate in the formation of multivesicular bodies (MVBs), which play an important role in the budding and release of viruses from infected cells. Indeed, Nef proliferated MVBs in cells, but only when its AIP1-binding site was intact. Finally, these functions of Nef were reproduced in primary macrophages, where the wild type but not mutant Nef proteins led to increased release of new viral particles from infected cells. Conclusion We conclude that by binding GagPol and AIP1, Nef not only proliferates MVBs but also contributes to the egress of viral particles from infected cells. PMID:16764724

  1. Resistance to octreotide LAR in acromegalic patients with high SSTR2 expression: analysis of AIP expression.

    PubMed

    Kasuki, Leandro; Colli, Leandro M; Elias, Paula C L; Castro, Margaret de; Gadelha, Mônica R

    2012-11-01

    We present here the clinical and molecular data of two patients with acromegaly treated with octreotide LAR after non-curative surgery, and who presented different responses to therapy. Somatostatin receptor type 2 and 5 (SSTR2 and SSTR5), and aryl hydrocarbon receptor-interacting protein (AIP) expression levels were analyzed by qPCR. In both cases, high SSTR2 and low SSTR5 expression levels were detected; however, only one of the patients achieved disease control after octreotide LAR therapy. When we analyzed AIP expression levels of both cases, the patient whose disease was controlled after therapy exhibited AIP expression levels that were two times higher than the patient whose disease was still active. These two cases illustrate that, although the currently available somatostatin analogs bind preferentially to SSTR2, some patients are not responsive to therapy despite high expression of this receptor. This difference could be explained by differences in post-receptor signaling pathways, including the recently described involvement of AIP.

  2. @NASA Wins Shorty Award

    NASA Image and Video Library

    2013-04-10

    A Shorty Award is seen Wednesday, April 10, 2013 at NASA Headquarters in Washington. NASA's official Twitter feed, @NASA, has won its second consecutive Shorty award for the best government use of social media. The Shorty Award honors the best of social media across sites such as Twitter, Facebook, Tumblr, YouTube, Foursquare and others. NASA took the prize Monday, April 8, at the fifth Shorty Awards ceremony in New York. The @NASA acceptance tweet was, "We're sharing the universe 1 tweet at a time. Be inspired! Follow @NASA & RT if you love science & space. #ShortyAwards." Photo Credit: (NASA/Carla Cioffi)

  3. Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP.

    PubMed

    Kamisawa, Terumi; Okazaki, Kazuichi; Kawa, Shigeyuki; Shimosegawa, Tooru; Tanaka, Masao

    2010-05-01

    Steroid therapy appeared to be a standard treatment for autoimmune pancreatitis (AIP), although some AIP patients improve spontaneously. The indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, and back pain, and the presence of symptomatic extrapancreatic lesions. Before steroid therapy, jaundice should be managed by biliary drainage in patients with obstructive jaundice, and blood glucose levels should be controlled in patients with diabetes mellitus. For the initial oral prednisolone dose for induction of remission, 0.6 mg/kg/day is recommended. The initial dose is administered for 2-4 weeks, and the dose is tapered by 5 mg every 1-2 weeks, based on changes in the clinical manifestations, biochemical blood tests (such as liver enzymes and IgG or IgG4 levels), and repeated imaging findings (US, CT, MRCP, ERCP, etc.). The dose is tapered to a maintenance dose (2.5-5 mg/day) over a period of 2-3 months. Steroid therapy should be stopped based on the disease activity in each case. Stopping of maintenance therapy should be planned within at least 3 years in cases with radiological and serological improvement. Re-administration or dose-up of steroid is effective for treating AIP relapses. The prognosis of AIP appears to be good over the short-term with steroid therapy. It is unclear whether the long-term outcome is good because there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy.

  4. The AIP (aryl hydrocarbon receptor-interacting protein) gene and its relation to the pathogenesis of pituitary adenomas.

    PubMed

    Lloyd, Catrin; Grossman, Ashley

    2014-08-01

    Pituitary adenomas are monoclonal neoplasms that may secrete excessive quantities of their endogenous hormones, or may not be associated with any obvious syndrome, in which case they are known as non-functioning pituitary adenomas. Around 2 % have been said to occur in a familial setting, in the absence of any other tumor, now described as familial isolated pituitary adenomas (FIPA). Some 15-30 % of such families harbor inactivating germ-line mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene, along with 20 % of pediatric seemingly sporadic cases. AIP mutants are referred to as having pituitary adenoma predisposition, and present with early onset, aggressive macroadenomas, most of which secrete somatotropin. Evidence from transfection studies implies that AIP acts as a tumor suppressor; although whether this is mediated through an interaction with the aryl hydrocarbon receptor, phosphodiesterases, or with cell cycle regulators such as survivin or RET remains controversial. However, at present an interaction with the cyclic AMP pathway seems most plausible. Recently, evidence has shown that AIP may act at the cell surface, causing changes in integrin function. The presence of AIP mutations in a significant proportion of FIPA families as well as in apparently sporadic cases, particularly in young patients, suggests a need to screen such patients for AIP mutations to enable better clinical management. However, the absence of AIP mutations in over half of such cases highlights the need to search for further gene mutations.

  5. Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort.

    PubMed

    Niyazoglu, Mutlu; Sayitoglu, Muge; Firtina, Sinem; Hatipoglu, Esra; Gazioglu, Nurperi; Kadioglu, Pinar

    2014-06-01

    Aryl hydrocarbon receptor-interacting protein (AIP) is associated with 15-20% of familial isolated pituitary adenomas and 50-80% of cases with AIP mutation exhibit a somatotropinoma. Herein we report clinical characteristics of a large family where AIP R304X variants have been identified. AIP mutation analysis was performed on a large (n = 52) Turkish family across six generations. Sella MRIs of 30 family members were obtained. Basal pituitary hormone levels were evaluated in 13 family members harboring an AIP mutation. Thirteen of 52 family members (25%) were found to have a heterozygous nonsense germline R304X mutation in the AIP gene. Seven of the 13 mutation carriers (53.8%) had current or previous history of pituitary adenoma. Of these 7 mutation carriers, all but one had somatotropinoma/somatolactotropinoma (85.7% of the pituitary adenomas). Of the 6 acromegaly patients with AIP mutation (F/M: 3/3) the mean age at diagnosis of acromegaly was 32 ± 10.3 years while the mean age of symptom onset was 24.8 ± 9.9 years. Three of the six (50%) acromegaly cases with AIP mutation within the family presented with a macroadenoma and none presented with gigantism. Biochemical disease control was achieved in 66.6% (4/6) of the mutation carriers with acromegaly after a mean follow-up period of 18.6 ± 17.6 years. Common phenotypic characteristics of familial pituitary adenoma or somatotropinoma due to AIP mutation vary between families or even between individuals within a family.

  6. Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation.

    PubMed

    van der Spuy, J; Cheetham, M E

    2004-08-01

    Mutations in the AIPL1 (aryl hydrocarbon receptor interacting protein-like 1) cause the blinding disease Leber's congenital amaurosis. AIPL1 is a homologue of the AIP. AIP functions as part of a chaperone heterocomplex to facilitate signalling by the AhR and plays an important role in regulating the nuclear translocation of the receptor. We review the evidence for the role of AIP in protein translocation and compare the potential functions of AIPL1 in the translocation of its interacting partner the NEDD8 ultimate buster protein 1.

  7. NMR assignments of the FKBP-type PPIase domain of the human aryl-hydrocarbon receptor-interacting protein (AIP).

    PubMed

    Linnert, Miriam; Haupt, Katja; Lin, Yi-Jan; Kissing, Sandra; Paschke, Anne-Katrin; Fischer, Gunter; Weiwad, Matthias; Lücke, Christian

    2012-10-01

    The aryl-hydrocarbon receptor-interacting protein (AIP) interacts with several protein binding partners and has been associated with pituitary tumor development. Here, we report nearly complete (1)H, (13)C and (15)N chemical shift assignments for the N-terminal AIP(2-166) segment, which has been predicted to represent a FKBP-type PPIase domain. Sequence alignment with the prototypic FKBP12, however, reveals disagreements between the AIP chemical shift index consensus and the corresponding FKBP12 secondary structure elements.

  8. AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.

    PubMed

    Min, Wang; Lin, Yan; Tang, Shibo; Yu, Luyang; Zhang, Haifeng; Wan, Ting; Luhn, Tricia; Fu, Haian; Chen, Hong

    2008-04-11

    Previously we have shown that AIP1 (apoptosis signal-regulating kinase [ASK]1-interacting protein 1), a novel member of the Ras-GAP protein family, facilitates dephosphorylation of ASK1 at pSer967 and subsequently 14-3-3 release from ASK1, leading to enhanced ASK1-JNK signaling. However, the phosphatase(s) responsible for ASK1 dephosphorylation at pSer967 has not been identified. In the present study, we identified protein phosphatase (PP)2A as a potential phosphatase in vascular endothelial cells (ECs). Tumor necrosis factor (TNF)-induced dephosphorylation of ASK1 pSer967 in ECs was blocked by PP2A inhibitor okadaic acid. Overexpression of PP2A catalytic subunit induced dephosphorylation of ASK1 pSer967 and activation of c-Jun N-terminal kinase (JNK). In contrast, a catalytic inactive form of PP2A or PP2A small interfering RNA blunted TNF-induced dephosphorylation of ASK1 pSer967 and activation of JNK without effects on NF-kappaB activation. Whereas AIP1, via its C2 domain, binds to ASK1, PP2A binds to the GAP domain of AIP1. Endogenous AIP1-PP2A complex can be detected in the resting state, and TNF induces a complex formation of AIP1-PP2A with ASK1. Furthermore, TNF-induced association of PP2A with ASK1 was diminished in AIP1-knockdown ECs, suggesting a critical role of AIP1 in recruiting PP2A to ASK1. TNF-signaling molecules TRAF2 and RIP1, known to be in complex with AIP1 and activate AIP1 by phosphorylating AIP1 at Ser604, are critical for TNF-induced ASK1 dephosphorylation. Finally, PP2A and AIP1 cooperatively induce activation of ASK1-JNK signaling and EC apoptosis, as demonstrated by both overexpression and small interfering RNA knockdown approaches. Taken together, our data support a critical role of PP2A-AIP1 complex in TNF-induced activation of ASK1-JNK apoptotic signaling.

  9. 28 CFR 301.314 - Establishing the amount of award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Establishing the amount of award. 301.314 Section 301.314 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.314 Establishing the amount of award. (a) If a claim for...

  10. Industry

    SciTech Connect

    Bernstein, Lenny; Roy, Joyashree; Delhotal, K. Casey; Harnisch, Jochen; Matsuhashi, Ryuji; Price, Lynn; Tanaka, Kanako; Worrell, Ernst; Yamba, Francis; Fengqi, Zhou; de la Rue du Can, Stephane; Gielen, Dolf; Joosen, Suzanne; Konar, Manaswita; Matysek, Anna; Miner, Reid; Okazaki, Teruo; Sanders, Johan; Sheinbaum Parado, Claudia

    2007-12-01

    This chapter addresses past, ongoing, and short (to 2010) and medium-term (to 2030) future actions that can be taken to mitigate GHG emissions from the manufacturing and process industries. Globally, and in most countries, CO{sub 2} accounts for more than 90% of CO{sub 2}-eq GHG emissions from the industrial sector (Price et al., 2006; US EPA, 2006b). These CO{sub 2} emissions arise from three sources: (1) the use of fossil fuels for energy, either directly by industry for heat and power generation or indirectly in the generation of purchased electricity and steam; (2) non-energy uses of fossil fuels in chemical processing and metal smelting; and (3) non-fossil fuel sources, for example cement and lime manufacture. Industrial processes also emit other GHGs, e.g.: (1) Nitrous oxide (N{sub 2}O) is emitted as a byproduct of adipic acid, nitric acid and caprolactam production; (2) HFC-23 is emitted as a byproduct of HCFC-22 production, a refrigerant, and also used in fluoroplastics manufacture; (3) Perfluorocarbons (PFCs) are emitted as byproducts of aluminium smelting and in semiconductor manufacture; (4) Sulphur hexafluoride (SF{sub 6}) is emitted in the manufacture, use and, decommissioning of gas insulated electrical switchgear, during the production of flat screen panels and semiconductors, from magnesium die casting and other industrial applications; (5) Methane (CH{sub 4}) is emitted as a byproduct of some chemical processes; and (6) CH{sub 4} and N{sub 2}O can be emitted by food industry waste streams. Many GHG emission mitigation options have been developed for the industrial sector. They fall into three categories: operating procedures, sector-wide technologies and process-specific technologies. A sampling of these options is discussed in Sections 7.2-7.4. The short- and medium-term potential for and cost of all classes of options are discussed in Section 7.5, barriers to the application of these options are addressed in Section 7.6 and the implication of

  11. Geoscience Information Society Award

    NASA Astrophysics Data System (ADS)

    The Geoscience Information Society (GIS) has announced the creation of the GIS-Mary B. Ansari Best Reference Work Award. The award is funded by a gift of $5000 from former GIS President Mary B. Ansari, currently Director for Branch Libraries and Library Administrative Services at the University of Nevada, Reno. The Best Reference Work Award has been given annually for 7 years, but now the GIS will begin to present the winner with a monetary award.The award will be $500 per year and will be presented to the author or editor of the geoscience reference work selected for the award. The money will be divided equally in cases of multiple authors.

  12. AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience.

    PubMed

    Ramírez-Rentería, Claudia; Hernández-Ramírez, Laura C; Portocarrero-Ortiz, Lesly; Vargas, Guadalupe; Melgar, Virgilio; Espinosa, Etual; Espinosa-de-Los-Monteros, Ana Laura; Sosa, Ernesto; González, Baldomero; Zúñiga, Sergio; Unterländer, Martina; Burger, Joachim; Stals, Karen; Bussell, Anne-Marie; Ellard, Sian; Dang, Mary; Iacovazzo, Donato; Kapur, Sonal; Gabrovska, Plamena; Radian, Serban; Roncaroli, Federico; Korbonits, Márta; Mercado, Moisés

    2016-08-01

    Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic acromegaly, their prevalence among young patients is nonnegligible. The objectives of this study were to evaluate the frequency of AIP mutations in a cohort of Mexican patients with acromegaly with disease onset before the age of 30 and to search for molecular abnormalities in the AIP gene in teeth obtained from the "Tampico Giant". Peripheral blood DNA from 71 patients with acromegaly (51 females) with disease onset <30 years was analysed (median age of disease onset of 23 years) and correlated with clinical, biochemical and imaging characteristics. Sequencing was also carried out in DNA extracted from teeth of the Tampico Giant. Five patients (7 %) harboured heterozygous, germline mutations of the AIP gene. In two of them (a 9-year-old girl with gigantism and a young man with symptoms of GH excess since age 14) the c.910C>T (p.Arg304Ter), well-known truncating mutation was identified; in one of these two cases and her identical twin sister, the mutation proved to be a de novo event, since neither of their parents were found to be carriers. In the remaining three patients, new mutations were identified: a frameshift mutation (c.976_977insC, p.Gly326AfsTer), an in-frame deletion (c.872_877del, p.Val291_Leu292del) and a nonsense mutation (c.868A > T, p.Lys290Ter), which are predicted to be pathogenic based on in silico analysis. Patients with AIP mutations tended to have an earlier onset of acromegaly and harboured larger and more invasive tumours. A previously described genetic variant of unknown significance (c.869C > T, p.Ala299Val) was identified in DNA from the Tampico Giant. The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts. Our results support the need for genetic evaluation of patients with early onset acromegaly.

  13. Wheels Shorty Award

    NASA Image and Video Library

    2011-03-30

    A Shorty Award is seen Wednesday, March 30, 2011 at NASA Headquarters in Washington. The award was presented to NASA astronaut Doug Wheelock for an image of the moon he took and posted to his Twitter account, @Astro_Wheels, while living aboard the International Space Station last year. The awards ceremony was held at the TimesCenter in New York City on Monday, March 28. Photo Credit: (NASA/Paul E. Alers)

  14. 2004 Small Business Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2004 award winner, Jeneil Biosurfactant Company, makes biobased, rhamnolipid surfactants by fermentation that are less toxic and more biodegradable than conventional surfactants.

  15. The Lashley Award.

    PubMed

    Dewsbury, Donald A

    2006-06-01

    The Karl Spencer Lashley Award for Distinguished Achievement in the Neurosciences has been bestowed upon 50 of the world's leading neuroscientists of the last half century but is not well known. It originated in 1953 when Lashley accumulated excess stock holdings and established a Fund for Neurobiology with 52,000 dollars to provide small grants for neurobiological research. Several years later the assets were transferred to the American Philosophical Society to administer and convert to an award for achievement in neurobiology The nature, amount, and format of the award have evolved ever since. These changes in the award and the characteristics of its recipients are described.

  16. Clean Air Excellence Awards

    EPA Pesticide Factsheets

    These non-monetary awards honor sustainable efforts toward pollutant emissions reduction from innovators in clean air technology, community action and outreach, policy development, and transportation efficiency.

  17. Wine: the increasing risk of a highly vulnerable industry globally to natural disasters and climate change (NH Division Outstanding ECS Award Lecture)

    NASA Astrophysics Data System (ADS)

    Daniell, James E.; Daniell, Trevor M.; Daniell, Katherine A.; Wenzel, Friedemann; Schäfer, Andreas M.; Kunz, Michael; Kunz-Plapp, Tina; Khazai, Bijan; Girard, Trevor; Burford, Robert

    2017-04-01

    Globally, well over 10 trillion in economic losses and over 10 million deaths can be attributed directly to natural disaster events from floods, earthquakes, storms, volcanoes and climatic effects historically (CATDAT - Daniell et al., 2016). When looking at the most vulnerable industries to natural disasters for each dollar invested the wine industry rates very highly, thus showing the risky and vulnerable nature of the wine business. Some effects of climate change will be shifting climates so that new grape growing areas are discovered and some traditional locations will require a change of grape variety to be planted, or will unsatisfactory for quality grape production. As new grape types are developed, some other grape types will become less viable leading to a global shift relative to the current state of the industry. The wine industry has been shown to have major losses via sudden shocks such as earthquakes in Chile (2010), Christchurch (2011) and Napa (2014) and hail through Burgundy (2012-2014). Wineries are often prone to other major disasters such as flood, storms, frost, fire or disease causing structural failure of assets, and significant production losses. Natural and man-made disasters play a key role in wine industry losses, and the variability of seasonal shifts and sudden natural shocks can often play a major role in the lifecycle and indeed the lifetime of wineries. Lessons learnt from winery disasters and climate impacts in Australia, Chile, New Zealand and USA are used as well as a comparison with those in Europe and other vulnerable centralised industries, such as cheese in Italy (2012 earthquake). For various natural disasters the structural engineering issues associated with wineries are examined with respect to infrastructure such as elevated steel tanks, as well as the importance of planning for earthquakes. The potential risk mitigation solutions are often simple to implement and are cost-effective in reducing significantly the risk

  18. Acromegaly Is More Severe in Patients With AHR or AIP Gene Variants Living in Highly Polluted Areas.

    PubMed

    Cannavo, S; Ragonese, M; Puglisi, S; Romeo, P D; Torre, M L; Alibrandi, A; Scaroni, C; Occhi, G; Ceccato, F; Regazzo, D; De Menis, E; Sartorato, P; Arnaldi, G; Trementino, L; Trimarchi, F; Ferrau, F

    2016-04-01

    In this multicentric study, we aimed to correlate the occurrence of AHR and/or AIP. genes variants in acromegalic patients with the disease severity and/or with the response to somatostatin analogs (SSa) treatment, according to pollution exposition.

  19. Presidential Green Chemistry Challenge: 1999 Greener Reaction Conditions Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 1999 award winner, Nalco Chemical Co., developed homogeneous dispersion polymerization with water as the solvent to make polymers to treat water in industrial and municipal operations.

  20. Presidential Green Chemistry Challenge: 2003 Designing Greener Chemicals Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2003 award winner, Shaw Industries, developed EcoWorx carpet tiles with a backing that uses less toxic materials. The carpet tile fiber and backing are readily separated for recycling.

  1. EPA Hosts Superfund Redevelopment Awards Ceremony in West Dallas

    EPA Pesticide Factsheets

    DALLAS - (Nov. 10, 2015) The U.S. Environmental Protection Agency (EPA) is presenting the Excellence in Site Reuse Award to the Dallas Housing Authority and Goodwill Industries of Dallas, Inc. for redeveloping portions of the RSR Corporation Superfu

  2. Presidential Green Chemistry Challenge: 1997 Designing Greener Chemicals Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 1997 award winner, Albright & Wilson Americas, discovered that tetrakis(hydroxymethyl)phosphonium sulfate, THPS, is an effective, safer biocide for use in industrial water systems.

  3. Presidential Green Chemistry Challenge: 2012 Greener Reaction Conditions Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2012 award winner, Cytec Industries, developed the MAX HT sodalite scale inhibitor for heat exchangers and pipes in the Bayer process, which converts bauxite into alumina.

  4. Presidential Green Chemistry Challenge: 2001 Designing Greener Chemicals Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2001 award winner, PPG Industries, developed cationic electrodeposition coatings with yttrium that resist corrosion in automobiles. Yttrium is a safe replacement for lead in this use.

  5. Baldridge award criteria structure encourages strategic innovation.

    PubMed

    2006-07-01

    Guided by the criteria established for the Malcolm Baldridge National Quality Award, St. Luke's Hospital in Kansas City, MO, and Baptist Hospital, in Pensacola, FL, have regularly sustained industry leading successes in reduced employee turnover, increased patient satisfaction, improved outcomes, and financial stability over the last five years.

  6. Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi.

    PubMed

    Gless, Bengt H; Peng, Pai; Pedersen, Katja D; Gotfredsen, Charlotte H; Ingmer, Hanne; Olsen, Christian A

    2017-10-06

    Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.

  7. Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia

    PubMed Central

    Panopoulos, Athanasia D.; Stirzaker, Roslynn A.; Hacking, Douglas F.; Tahtamouni, Lubna H.; Willson, Tracy A.; Mielke, Lisa A.; Henley, Katya J.; Zhang, Jian-Guo; Wicks, Ian P.; Stevenson, William S.; Nurden, Paquita; Watowich, Stephanie S.; Justice, Monica J.

    2007-01-01

    A pivotal mediator of actin dynamics is the protein cofilin, which promotes filament severing and depolymerization, facilitating the breakdown of existing filaments, and the enhancement of filament growth from newly created barbed ends. It does so in concert with actin interacting protein 1 (Aip1), which serves to accelerate cofilin's activity. While progress has been made in understanding its biochemical functions, the physiologic processes the cofilin/Aip1 complex regulates, particularly in higher organisms, are yet to be determined. We have generated an allelic series for WD40 repeat protein 1 (Wdr1), the mammalian homolog of Aip1, and report that reductions in Wdr1 function produce a dramatic phenotype gradient. While severe loss of function at the Wdr1 locus causes embryonic lethality, macrothrombocytopenia and autoinflammatory disease develop in mice carrying hypomorphic alleles. Macrothrombocytopenia is the result of megakaryocyte maturation defects, which lead to a failure of normal platelet shedding. Autoinflammatory disease, which is bone marrow–derived yet nonlymphoid in origin, is characterized by a massive infiltration of neutrophils into inflammatory lesions. Cytoskeletal responses are impaired in Wdr1 mutant neutrophils. These studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils, indicating that cofilin-mediated actin dynamics are critically important to the development and function of both cell types. PMID:17515402

  8. Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo

    PubMed Central

    Lin, Meng-Chi; Galletta, Brian J.; Sept, David; Cooper, John A.

    2010-01-01

    Actin-filament disassembly is crucial for actin-based motility, to control filament network architecture and to regenerate subunits for assembly. Here, we examined the roles of three actin cytoskeletal proteins, coronin, cofilin and Aip1, which have been suggested to combine in various ways to control actin dynamics by promoting or regulating disassembly. We studied their functions during the endocytosis process in budding yeast, where actin-filament dynamics at the cortical actin ‘patch’ contribute to the formation and movement of endocytic vesicles. We found that all three proteins were recruited during the late phase of the life of the actin patch. They all arrived at the same time, when actin and other actin-associated proteins were leaving the patch. Cofilin point mutations influenced the localization of coronin and Aip1, but the complete loss of coronin had no effect on localization of cofilin or Aip1. Using quantitative patch motion analysis and comparing mutant alleles, the phenotypes for mutations of the three genes showed some commonalities, but also some striking differences. Cofilin was clearly the most important; it displayed the most severe mutant phenotypes affecting actin-patch assembly and movement. Together, the results suggest that all three proteins work together to promote actin disassembly, but not in a simple way, and not with equal importance. PMID:20332110

  9. AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma.

    PubMed

    Nishizawa, H; Fukuoka, H; Iguchi, G; Inoshita, N; Yamada, S; Takahashi, Y

    2013-05-01

    Pituitary adenoma with neuronal choristoma (PANCH) is a rare condition that includes ganglion cells and GH-producing tumor that is characterized by sparsely granulated somatotroph cell type. However, the pathophysiology of this condition remains to be elucidated. We report a case of 46-year-old woman with acromegaly caused by PANCH. The patient had a large and invasive macroadenoma that was resistant to preoperative therapy with somatostatin analogue (SSA) and dopamine agonist. Histological examination showed typical diffuse, chromophobe-type adenoma containing ganglion cells, and sparsely granulated somatotroph cell type, which were consistent with PANCH. Genetic analysis showed heterozygous germline missense mutation in the AIP gene that results in Y261X amino acid substitution. The clinical characteristics of acromegaly associated with AIP mutations are reportedly macroadenomas with tumor extension and invasion, lower decreases in GH and IGF-I and less tumor shrinkage with SSA treatment, and sparsely granulated somatotroph cell type, which are comparable with those observed in PANCH. Taken together, the mutation in AIP gene may explain the clinical characteristics and pathogenesis of PANCH.

  10. Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.

    PubMed

    Raitila, Anniina; Lehtonen, Heli J; Arola, Johanna; Heliövaara, Elina; Ahlsten, Manuel; Georgitsi, Marianthi; Jalanko, Anu; Paetau, Anders; Aaltonen, Lauri A; Karhu, Auli

    2010-10-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigenesis, we generated an Aip mouse model. Heterozygous mice developed normally but were prone to pituitary adenomas, in particular to those secreting GH. A complete loss of AIP was detected in these lesions, and full penetrance was reached at the age of 15 months. No excess of any other tumor type was found. Ki-67 analysis indicated that Aip-deficient tumors have higher proliferation rates compared with Aip-proficient tumors, suggesting a more aggressive disease. Similar to human AIP-deficient pituitary adenomas, immunohistochemical studies showed that expression of aryl hydrocarbon receptor nuclear translocator 1 or 2 (ARNT or ARNT2) protein was lost in the mouse tumors, suggesting that mechanisms of AIP-related tumorigenesis involve aberrant ARNT function. The Aip(+/-) mouse appears to be an excellent model for the respective human disease phenotype. This model constitutes a tool to further study AIP-associated pituitary tumorigenesis and may be potentially valuable in efforts to develop therapeutic strategies to treat pituitary adenomas.

  11. The Awards Ceremony.

    ERIC Educational Resources Information Center

    Morrow, Susan R.

    1997-01-01

    Provides an assignment for a business communication or a public speaking course from junior high to college level. States a minimum of three oral presentations are necessary for the assignment encompassing an announcement of the awards competition, the voting process and incentives for winning an award, and the ceremony held on the last day of…

  12. Creativity Awards: Great Expectations?

    ERIC Educational Resources Information Center

    Kilgour, Mark; Sasser, Sheila; Koslow, Scott

    2013-01-01

    Given the creativity inherent in advertising, one useful measure of creativity may be the advertising creativity award. Although creativity awards have been used by academics, agencies, and clients as indicators of exemplary creative work, there is surprisingly little research as to what creative elements they actually represent. Senior agency…

  13. Creativity Awards: Great Expectations?

    ERIC Educational Resources Information Center

    Kilgour, Mark; Sasser, Sheila; Koslow, Scott

    2013-01-01

    Given the creativity inherent in advertising, one useful measure of creativity may be the advertising creativity award. Although creativity awards have been used by academics, agencies, and clients as indicators of exemplary creative work, there is surprisingly little research as to what creative elements they actually represent. Senior agency…

  14. A review of 1985 Volvo Award winner in clinical science: objective assessment of spine function following industrial injury: a prospective study with comparison group and 1-year follow-up.

    PubMed

    Rainville, James; Kim, Richard S; Katz, Jeffrey N

    2007-08-15

    It is now 2 decades since Mayer et al published their Volvo Award-winning paper entitled "Objective assessment of spine function following industrial injury: a prospective study with comparison group and one-year follow-up." Their landmark paper reported that return to work rates of patients that underwent a "functional restoration" treatment program were double that of a comparative group of patients that were denied treatment by their insurers. These results were considered extraordinary and inspired both debate and enthusiasm. Our goal is to review this landmark study, report on its strengths and weaknesses, and review the studies that have attempted to replicate this work in other settings. We also highlight its contribution to our current knowledge about the treatment of back pain and disability. The major weaknesses of the paper of Mayer et al are the possibility of selection bias in the development of their cohort of patients and the lack of a true randomized controlled study design. These factors may have inflated the rates of return to work. Regardless, their reported results were robust, and cannot be easily dismissed. During the last 20 years, this treatment model has received considerable study worldwide, and it is generally agreed that it is superior to standard care for reducing work absence in patients with chronic low back pain. Additionally, the concepts underlying functional restoration have been found to be highly relevant to patients with chronic low back pain, medical providers, and disability systems and continue to gain acceptance and integration into the care of patients throughout the industrialized world.

  15. Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

    PubMed Central

    Hernández-Ramírez, Laura C.; Martucci, Federico; Morgan, Rhodri M. L.; Trivellin, Giampaolo; Tilley, Daniel; Ramos-Guajardo, Nancy; Iacovazzo, Donato; D'Acquisto, Fulvio; Prodromou, Chrisostomos

    2016-01-01

    Context: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood. We have identified the primary mechanism of loss of function for missense AIPmuts. Objective: This study sought to analyze the mechanism/speed of protein turnover of wild-type and missense AIP variants, correlating protein half-life with clinical parameters. Design and Setting: Half-life and protein–protein interaction experiments and cross-sectional analysis of AIPmut positive patients' data were performed in a clinical academic research institution. Patients: Data were obtained from our cohort of pituitary adenoma patients and literature-reported cases. Interventions: Protein turnover of endogenous AIP in two cell lines and fifteen AIP variants overexpressed in HEK293 cells was analyzed via cycloheximide chase and proteasome inhibition. Glutathione-S-transferase pull-down and quantitative mass spectrometry identified proteins involved in AIP degradation; results were confirmed by coimmunoprecipitation and gene knockdown. Relevant clinical data was collected. Main Outcome Measures: Half-life of wild-type and mutant AIP proteins and its correlation with clinical parameters. Results: Endogenous AIP half-life was similar in HEK293 and lymphoblastoid cells (43.5 and 32.7 h). AIP variants were divided into stable proteins (median, 77.7 h; interquartile range [IQR], 60.7–92.9 h), and those with short (median, 27 h; IQR, 21.6–28.7 h) or very short (median, 7.7 h; IQR, 5.6–10.5 h) half-life; proteasomal inhibition rescued the rapid degradation of mutant proteins. The experimental half-life significantly correlated with age at diagnosis of acromegaly/gigantism (r = 0.411; P = .002). The FBXO3-containing SKP1–CUL1–F-box protein complex was identified as the E3 ubiquitin-ligase recognizing AIP. Conclusions: AIP is a stable protein, driven to ubiquitination by the SKP1–CUL1–F-box protein complex

  16. ADSA Foundation Scholar Award. Critical issues affecting the future of dairy industry: individual contributions in the scope of a global approach.

    PubMed

    Malcata, F X

    1999-08-01

    Several constraints that have been affecting the dairy industry are identified in a critical fashion, and directions are given with an emphasis on food processing implemented at the postproduction level. The rationale for modifications aimed at enhancing the appeal of condensed dairy products should be consubstantiated in strengthening of organoleptic characteristics, improvement of nutraceutical impact, and reduction of polluting power. This enumeration follows an order of increasing time scale required for consumer perception and increasing size scale associated with expected impact. Pursuance of such streamlines should lead to manufacture of dairy products that resemble nature more closely in terms of milk coagulation, milk fat modification, milk fermentation, whey fermentation, and starter culture addition. Directions for research and development anticipated as useful and effective in this endeavor, and which have been previously and consistently adopted in the development of an individual research program, are characterization and development of alternative rennets from plant sources, development of starter and nonstarter cultures from adventitious microflora, utilization of probiotic strains as starter cultures, upgrading of whey via physical or fermentation routes, and modification of milk fat via lipase-mediated interesterification reactions.

  17. The Lennart Nilsson Award.

    PubMed

    Peres, M

    2001-01-01

    This article takes a brief look at the photography of Lennart Nilsson as well as the history of, and the formation of a foundation to raise monies for the establishment of an award in his name. Subsequently, a board and an international nominating committee evolved to select individuals to receive the award. Honorees are chosen based on the merits of their efforts in scientific imagery that, like the photography of Nilsson, reveal the unseen in the natural world. Finally, this article discusses the work of the latest two recipients of the award and invites readers to participate in the nomination process.

  18. BHP Billiton Science Teacher Awards

    ERIC Educational Resources Information Center

    Chittleborough, Gail; Campbell, Coral

    2012-01-01

    The prestigious BHP Billiton Science Teacher Awards are awarded annually to one teacher from each state of Australia. The awards recognise and value the time and effort that teachers give to the profession and to students conducting scientific research projects. This paper examines the Science Award scheme to identify the characteristics common to…

  19. BHP Billiton Science Teacher Awards

    ERIC Educational Resources Information Center

    Chittleborough, Gail; Campbell, Coral

    2012-01-01

    The prestigious BHP Billiton Science Teacher Awards are awarded annually to one teacher from each state of Australia. The awards recognise and value the time and effort that teachers give to the profession and to students conducting scientific research projects. This paper examines the Science Award scheme to identify the characteristics common to…

  20. Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal α-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition

    PubMed Central

    Morgan, Rhodri M. L.; Hernández-Ramírez, Laura C.; Trivellin, Giampaolo; Zhou, Lihong; Roe, S. Mark; Korbonits, Márta; Prodromou, Chrisostomos

    2012-01-01

    Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain of AIP at high resolution, which has allowed a detailed analysis of how disease-associated mutations impact on the structural integrity of the TPR domain. A subset of C-terminal α-7 helix (Cα-7h) mutations, R304* (nonsense mutation), R304Q, Q307* and R325Q, a known site for AhR and PDE4A5 client-protein interaction, occur beyond those that interact with the conserved MEEVD and EDDVE sequences of HSP90 and TOMM20. These C-terminal AIP mutations appear to only disrupt client-protein binding to the Cα-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved HSP90 motif, MEEVD, and the equivalent sequence (EDDVE) of TOMM20. PMID:23300914

  1. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.

    PubMed

    Morgan, Rhodri M L; Hernández-Ramírez, Laura C; Trivellin, Giampaolo; Zhou, Lihong; Roe, S Mark; Korbonits, Márta; Prodromou, Chrisostomos

    2012-01-01

    Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain of AIP at high resolution, which has allowed a detailed analysis of how disease-associated mutations impact on the structural integrity of the TPR domain. A subset of C-terminal α-7 helix (Cα-7h) mutations, R304* (nonsense mutation), R304Q, Q307* and R325Q, a known site for AhR and PDE4A5 client-protein interaction, occur beyond those that interact with the conserved MEEVD and EDDVE sequences of HSP90 and TOMM20. These C-terminal AIP mutations appear to only disrupt client-protein binding to the Cα-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved HSP90 motif, MEEVD, and the equivalent sequence (EDDVE) of TOMM20.

  2. The Olive Branch Awards.

    ERIC Educational Resources Information Center

    Harnack, William

    1984-01-01

    The first annual Olive Branch Awards, sponsored by the Writers' and Publishers Alliance and the Editors' Organizing Committee, were given to ten magazines, out of 60 that submitted entries. Winning entries are described briefly. (IM)

  3. 2015 Gulf Guardian Awards

    EPA Pesticide Factsheets

    The Gulf of Mexico Program Partnership developed the Gulf Guardian awards as a way to recognize and honor the businesses, community groups, individuals, and agencies that are taking positive steps to keep the Gulf healthy, beautiful and productive.

  4. Tribal Awarded Grants

    EPA Pesticide Factsheets

    The DERA Tribal Program awards clean diesel grants specifically for tribal nations. The Diesel Emissions Reduction Act (DERA) appropriates funds for these projects. Publication Numbers: EPA-420-B-13-025 and EPA-420-P-11-001.

  5. The Olive Branch Awards.

    ERIC Educational Resources Information Center

    Harnack, William

    1984-01-01

    The first annual Olive Branch Awards, sponsored by the Writers' and Publishers Alliance and the Editors' Organizing Committee, were given to ten magazines, out of 60 that submitted entries. Winning entries are described briefly. (IM)

  6. Presidential Teacher Award Winners

    NASA Image and Video Library

    2011-05-19

    NASA Administrator Charles Bolden speaks to recipients of the Presidential Award for Excellence in Mathematics and Science Teaching at NASA Headquarters in Washington on Wednesday, May 19, 2011. Photo Credit: (NASA/Paul E. Alers)

  7. Teller Award Acceptance Speech

    NASA Astrophysics Data System (ADS)

    McCrory, Robert L.

    It is indeed an honor to receive an award named for such an accomplished and famous physicist who is present with us today, Dr. Edward Teller. In thinking over what to say on this occasion, I noted that the Teller Award was given for pioneering research in controlled fusion, in controlling fusion for the benefit of mankind. I think everyone in this audience certainly would agree that this lofty goal is truly one of the unconquered, grand challenges in applied physics.

  8. Tectonics wins AAP Award

    NASA Astrophysics Data System (ADS)

    AGU's newest journal, Tectonics, won the 1983 award for excellence in journal design and production given by the Association of American Publishers, Inc. (AAP), in the eighth annual professional and scholarly publishing awards competition. Edited by John F. Dewey, the bimonthly journal is a joint publication of AGU and the European Geophysical Society. Paul E. Tapponnier is the European editor and B.C. Burchfiel is the North American editor. The journal is now in its third year of publication.

  9. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA Deputy Administrator Lori Garver speaks after being given the Women in Aerospace's Outstanding Member Award at the organization's annual awards ceremony and banquet held at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Four current NASA leaders and one retiree were recognized for their work by Women in Aerospace. The event celebrates women's professional excellence in aerospace and honors women who have made outstanding contributions to the aerospace community. Photo Credit: (NASA/Bill Ingalls)

  10. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA Headquarters Program Planning Specialist Beth Beck speaks after being given the Women in Aerospace's Aerospace Awareness Award at the organization's annual awards ceremony and banquet held at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Four current NASA leaders and one retiree were recognized for their work by Women in Aerospace. The event celebrates women's professional excellence in aerospace and honors women who have made outstanding contributions to the aerospace community. Photo Credit: (NASA/Bill Ingalls)

  11. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA's Langley Research Center Lesa Roe speaks after being given the Women in Aerospace's Leadership Award at the organization's annual awards ceremony and banquet held at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Four current NASA leaders and one retiree were recognized for their work by Women in Aerospace. The event celebrates women's professional excellence in aerospace and honors women who have made outstanding contributions to the aerospace community. Photo Credit: (NASA/Bill Ingalls)

  12. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers

    PubMed Central

    Hernández-Ramírez, Laura C.; Gabrovska, Plamena; Dénes, Judit; Stals, Karen; Trivellin, Giampaolo; Tilley, Daniel; Ferraù, Francesco; Evanson, Jane; Ellard, Sian; Grossman, Ashley B.; Roncaroli, Federico; Gadelha, Mônica R.

    2015-01-01

    Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease. Objective: To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members. Design: This was an observational, longitudinal study conducted over 7 years. Setting: International collaborative study conducted at referral centers for pituitary diseases. Participants: FIPA families (n = 216) and sporadic young-onset (≤30 y) pituitary adenoma patients (n = 404) participated in the study. Interventions: We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant. Main Outcome Measure(s): We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis. Results: Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals. A total of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening. Conclusions: A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas. PMID

  13. Spatial Representations in Local Field Potential Activity of Primate Anterior Intraparietal Cortex (AIP).

    PubMed

    Lehmann, Sebastian J; Scherberger, Hansjörg

    2015-01-01

    The execution of reach-to-grasp movements in order to interact with our environment is an important subset of the human movement repertoire. To coordinate such goal-directed movements, information about the relative spatial position of target and effector (in this case the hand) has to be continuously integrated and processed. Recently, we reported the existence of spatial representations in spiking-activity of the cortical fronto-parietal grasp network (Lehmann & Scherberger 2013), and in particular in the anterior intraparietal cortex (AIP). To further investigate the nature of these spatial representations, we explored in two rhesus monkeys (Macaca mulatta) how different frequency bands of the local field potential (LFP) in AIP are modulated by grip type, target position, and gaze position, during the planning and execution of reach-to-grasp movements. We systematically varied grasp type, spatial target, and gaze position and found that both spatial and grasp information were encoded in a variety of frequency bands (1-13Hz, 13-30Hz, 30-60Hz, and 60-100Hz, respectively). Whereas the representation of grasp type strongly increased towards and during movement execution, spatial information was represented throughout the task. Both spatial and grasp type representations could be readily decoded from all frequency bands. The fact that grasp type and spatial (reach) information was found not only in spiking activity, but also in various LFP frequency bands of AIP, might significantly contribute to the development of LFP-based neural interfaces for the control of upper limb prostheses.

  14. Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

    PubMed

    Vasquez, Joseph K; Tal-Gan, Yftah; Cornilescu, Gabriel; Tyler, Kimberly A; Blackwell, Helen E

    2017-02-16

    The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mimetics of AIPs for use as chemical tools to study QS in S. aureus. Herein, we report new peptidomimetic AgrC receptor inhibitors based on a tail-truncated AIP-II peptide that have almost analogous inhibitory activities to the parent peptide. Structural comparison of one of these peptidomimetics to the parent peptide and a highly potent, all-peptide-derived, S. aureus agr inhibitor (AIP-III D4A) revealed a conserved hydrophobic motif and overall amphipathic nature. Our results suggest that the AIP scaffold is amenable to structural mimicry and minimization for the development of synthetic agr inhibitors. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred.

    PubMed

    Cansu, Güven Barış; Taşkıran, Bengür; Trivellin, Giampaolo; Faucz, Fabio R; Stratakis, Constantine A

    2016-07-01

    Familial isolated pituitary adenomas (FIPA) constitute 2-3% of pituitary tumours. AIP is the most commonly mutated gene in FIPA. We herein report a novel germline mutation of the AIP gene in a family with FIPA. We present two patients, a father and his 12-year-old daughter, diagnosed clinically and using laboratory measures with acromegaly-gigantism. Both underwent transsphenoidal hypophyseal surgery for macroadenomas. We initially detected a novel heterozygous germline AIP mutation, c.836G>A (p.W279*), in the father's DNA. We then found the same mutation in his affected daughter. Pituitary adenomas associated with AIP mutations mostly present as FIPA (68%) at an early age (78% occur at <30 years old). They are often growth hormone (GH) - or prolactin - secreting macroadenomas (88%) that have already extended beyond the sella at the time of diagnosis. Acromegalic cases are resistant to somatostatin analogues and multimodal management is frequently essential to control the disease. Our patients had normalized GH/IGF-1 values soon after surgery, although enough time may not have elapsed to reach final cure. While penetrance of the disease can be as low as 10% in FIPA, especially children and young patients with somatotropinoma and prolactinoma should be surveyed for inactivating mutations or deletions in AIP. Determining the causative mutations may be of assistance in early diagnosis, treatment success, and genetic counseling.

  16. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures (Invited)

    NASA Astrophysics Data System (ADS)

    Nativi, S.; Santoro, M.

    2009-12-01

    Currently, one of the major challenges for scientific community is the study of climate change effects on life on Earth. To achieve this, it is crucial to understand how climate change will impact on biodiversity and, in this context, several application scenarios require modeling the impact of climate change on distribution of individual species. In the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2), the Climate Change & Biodiversity thematic Working Group developed three significant user scenarios. A couple of them make use of a GEOSS-based framework to study the impact of climate change factors on regional species distribution. The presentation introduces and discusses this framework which provides an interoperability infrastructures to loosely couple standard services and components to discover and access climate and biodiversity data, and run forecast and processing models. The framework is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components publish climate, environmental and biodiversity datasets; e)Ecological Niche Model Server: this component is able to run one or more Ecological Niche Models (ENM) on selected biodiversity and climate datasets; f)Data Access

  17. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures

    NASA Astrophysics Data System (ADS)

    Nativi, Stefano; Santoro, Mattia

    2010-05-01

    In the last years, scientific community is producing great efforts in order to study the effects of climate change on life on Earth. In this general framework, a key role is played by the impact of climate change on biodiversity. To assess this, several use scenarios require the modeling of climatological change impact on the regional distribution of biodiversity species. Designing and developing interoperability infrastructures which enable scientists to search, discover, access and use multi-disciplinary resources (i.e. datasets, services, models, etc.) is currently one of the main research fields for the Earth and Space Science Informatics. This presentation introduces and discusses an interoperability infrastructure which implements the discovery, access, and chaining of loosely-coupled resources in the climatology and biodiversity domains. This allows to set up and run forecast and processing models. The presented framework was successfully developed and experimented in the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2) Climate Change & Biodiversity thematic Working Group. This interoperability infrastructure is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components

  18. AIP mutation in pituitary adenomas in the 18th century and today.

    PubMed

    Chahal, Harvinder S; Stals, Karen; Unterländer, Martina; Balding, David J; Thomas, Mark G; Kumar, Ajith V; Besser, G Michael; Atkinson, A Brew; Morrison, Patrick J; Howlett, Trevor A; Levy, Miles J; Orme, Steve M; Akker, Scott A; Abel, Richard L; Grossman, Ashley B; Burger, Joachim; Ellard, Sian; Korbonits, Márta

    2011-01-06

    Gigantism results when a growth hormone-secreting pituitary adenoma is present before epiphyseal fusion. In 1909, when Harvey Cushing examined the skeleton of an Irish patient who lived from 1761 to 1783, he noted an enlarged pituitary fossa. We extracted DNA from the patient's teeth and identified a germline mutation in the aryl hydrocarbon-interacting protein gene (AIP). Four contemporary Northern Irish families who presented with gigantism, acromegaly, or prolactinoma have the same mutation and haplotype associated with the mutated gene. Using coalescent theory, we infer that these persons share a common ancestor who lived about 57 to 66 generations earlier.

  19. 28 CFR 345.73 - Procedures for granting awards for suggestions or inventions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Procedures for granting awards for suggestions or inventions. 345.73 Section 345.73 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.73...

  20. 28 CFR 345.73 - Procedures for granting awards for suggestions or inventions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Procedures for granting awards for suggestions or inventions. 345.73 Section 345.73 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE FEDERAL PRISON INDUSTRIES (FPI) INMATE WORK PROGRAMS Awards Program § 345.73...

  1. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.

    PubMed

    Katayama, Hiroshi; Sasai, Kaori; Czerniak, Bogdan A; Carter, Jennifer L; Sen, Subrata

    2007-12-01

    Aurora-A is an oncogenic kinase that plays essential roles in mitosis as well as cell survival. Aurora-A interacting protein (AIP) was identified as a negative regulator of Aurora-A with its ectopic over expression inducing destabilization of Aurora-A protein. Here we present evidence that in human cells, contrary to the earlier report, AIP functions in stabilizing rather than destabilizing Aurora-A. Furthermore, AIP is phosphorylated on Serine 70 by Aurora-A but not Aurora-B and expression of phosphorylation mimic mutant of AIP results in prolonged protein stability compared to unphosphorylatable mutant. We observed that when co-expressed with AIP, protein levels of both Aurora-A and Aurora-B are markedly elevated regardless of their kinase activities and phosphorylation state of AIP. Interaction of Aurora kinases with AIP is necessary for this elevated stability. This phenomenon is commonly detected in several human cancer cell lines used in this study. Depletion of AIP by RNA interference decreased Aurora-A but not Aurora-B in two of the three cell lines analyzed, indicating that under physiological condition, AIP functions in stabilization of Aurora-A but not Aurora-B, though this regulation may be dependent on additional factors as well. Further, AIP siRNA induced cell cycle arrest at G2/M, which is consistent with anticipated loss of function of Aurora-A in these cells. Thus, our study provides the first evidence of a role for AIP in G2/M cell cycle progression by cooperatively regulating protein stabilization of its up-stream regulator, Aurora-A kinase through protein-protein interaction as well as protein phosphorylation.

  2. Advanced Information Processing System (AIPS)-based fault tolerant avionics architecture for launch vehicles

    NASA Technical Reports Server (NTRS)

    Lala, Jaynarayan H.; Harper, Richard E.; Jaskowiak, Kenneth R.; Rosch, Gene; Alger, Linda S.; Schor, Andrei L.

    1990-01-01

    An avionics architecture for the advanced launch system (ALS) that uses validated hardware and software building blocks developed under the advanced information processing system program is presented. The AIPS for ALS architecture defined is preliminary, and reliability requirements can be met by the AIPS hardware and software building blocks that are built using the state-of-the-art technology available in the 1992-93 time frame. The level of detail in the architecture definition reflects the level of detail available in the ALS requirements. As the avionics requirements are refined, the architecture can also be refined and defined in greater detail with the help of analysis and simulation tools. A useful methodology is demonstrated for investigating the impact of the avionics suite to the recurring cost of the ALS. It is shown that allowing the vehicle to launch with selected detected failures can potentially reduce the recurring launch costs. A comparative analysis shows that validated fault-tolerant avionics built out of Class B parts can result in lower life-cycle-cost in comparison to simplex avionics built out of Class S parts or other redundant architectures.

  3. AIP study of multi-institutional collaborations: Phase 1, High-energy physics

    SciTech Connect

    Sisk, B.; Maloney, L.; Warnow-Blewett, J.

    1992-01-01

    The title of this catalog is to be taken literally. Our coverage is selective. Laboratory archivists at CERN, Fermilab, Lawrence Berkeley Laboratory, and SLAC were generous in providing descriptions of records of particular relevance to experiments in high-energy physics; descriptions of records at Brookhaven were prepared by the AIP. Our catalog of these records in no way reflects the laboratories' holdings of valuable documentation. Most of the records located by the project relate to our probes.'' These were in-depth studies of three highly-significant collaborations: the discoveries of the psi at SLAC and the upsilon at Fermilab and the CLEO experiment and the origins of the Cornell Electron Storage Ring at Cornell University. The AIP study conducted a large number of interviews on more than 20 additional experiments; they are covered in this catalog. In the process of interviewing, we located valuable files-especially professional papers in the possession of individual physicists. It will take considerable effort and a number of years before these collections can be secured in appropriate repositories; they are not included here.

  4. Triangles have goals too: understanding action representation in left aIPS.

    PubMed

    Ramsey, Richard; Hamilton, Antonia F de C

    2010-07-01

    Humans freely interpret moving shapes as being "alive" and having social intentions, such as beliefs and desires. The brain systems underpinning these processes are the same as those used to detect animacy and infer mental states from human behaviour. However, it is not yet known if the brain systems that respond to human action-goals also respond to the action-goals of shapes. In the present paper, we used a repetition suppression paradigm during functional magnetic resonance imaging (fMRI) to examine brain systems that respond to the action-goals of shapes. Participants watched video clips of simple, geometrical shapes performing different 'take-object' goals. Repeated presentation of the same goal suppressed the blood oxygen level-dependent (BOLD) response in left anterior intraparietal sulcus (aIPS), a brain region known to distinguish the goals of human hand actions. This finding shows that left aIPS shows similar sensitivity to the action-goals of human and non-human agents. Our data complement previous work on animacy perception and mental state inference, which suggest components of the social brain are driven by the type of action comprehension that is engaged rather than by the form of the acting agent (i.e., human or shape). Further, the results have consequence for theories of goal understanding in situations without access to biological form or motion.

  5. Advanced Information Processing System (AIPS)-based fault tolerant avionics architecture for launch vehicles

    NASA Technical Reports Server (NTRS)

    Lala, Jaynarayan H.; Harper, Richard E.; Jaskowiak, Kenneth R.; Rosch, Gene; Alger, Linda S.; Schor, Andrei L.

    1990-01-01

    An avionics architecture for the advanced launch system (ALS) that uses validated hardware and software building blocks developed under the advanced information processing system program is presented. The AIPS for ALS architecture defined is preliminary, and reliability requirements can be met by the AIPS hardware and software building blocks that are built using the state-of-the-art technology available in the 1992-93 time frame. The level of detail in the architecture definition reflects the level of detail available in the ALS requirements. As the avionics requirements are refined, the architecture can also be refined and defined in greater detail with the help of analysis and simulation tools. A useful methodology is demonstrated for investigating the impact of the avionics suite to the recurring cost of the ALS. It is shown that allowing the vehicle to launch with selected detected failures can potentially reduce the recurring launch costs. A comparative analysis shows that validated fault-tolerant avionics built out of Class B parts can result in lower life-cycle-cost in comparison to simplex avionics built out of Class S parts or other redundant architectures.

  6. Web Services for Astronomical Databases: Connecting AIPS++ to the Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Douthit, M. C.

    2002-12-01

    In the year 2010, the NRAO will be operating four of the world's most powerful radio telescopes: GBT, EVLA, VLBA, and ALMA (with international partnership). Multi-Terabyte data sets will quickly accumulate with a rate of twenty-five to fifty Megabytes of data per second generated by ALMA and EVLA each. It will be imperative for scientists to possess software capable of automated data reduction, image synthesis, and archiving. With the evolution of AIPS++ and the recently developed concepts of the image pipeline, the participation of the NRAO in the virtual observatories of the future is now on the horizon giving birth to the need for fast archive access and web service development in AIPS++. When the software package began over 10 years ago, it was not designed for data transfer via the web. In response to the demands of the NVO, we have designed and implemented an application layer that will allow our system to communicate with others. Sponsored by the NRAO and California State University, San Marcos.

  7. A case of focal autoimmune pancreatitis (AIP) mimicking an intraductal papillary mucinous neoplasm (IPMN).

    PubMed

    Nakaji, So; Hirata, Nobuto; Fujii, Hiroyuki; Iwaki, Kosuke; Shiratori, Toshiyasu; Kobayashi, Masayoshi; Wakasugi, Satoshi; Ishii, Eiji; Takeyama, Hiroyuki; Hoshi, Kazuei

    2013-08-01

    The present case involved a 76-year-old man with a cystic mass in the head of his pancreas. The cystic lesion, which measured 17.7 × 9.8 mm, was first detected by ultrasonography (US) at the age of 72 years. Follow-up endoscopic ultrasonography (EUS) performed at 4 years after the lesion had first been detected revealed a mural nodule measuring 14.0 × 8.4 mm in the cyst. Endoscopic retrograde pancreatography (ERP) imaging revealed that the main pancreatic duct was in communication with the cyst and that there was no irregular narrowing of the main pancreatic duct. On the basis of these results, the patient was diagnosed with an intraductal papillary mucinous neoplasm (IPMN), and stomach-preserving pancreaticoduodenectomy was performed. A histopathological examination revealed that the interior of the cystic part of the lesion was lined by a pancreatic ductal epithelium. A pathological examination of the nodular lesion detected storiform fibrosis, severe lymphoplasmacytic infiltration, and hyperplasia in the pancreatic duct epithelium together with a small amount of mucus. On immunohistological staining, the infiltrating lymphoplasmacytes were found to be positive for IgG4. Accordingly, the patient was diagnosed with focal autoimmune pancreatitis (AIP). In conclusion, we reported a case of focal AIP mimicking IPMN. This case showed neither enlargement of the pancreas nor irregular narrowing of the main pancreatic duct.

  8. EuroGEOSS/GENESIS ``e-Habitat'' AIP-3 Use Scenario

    NASA Astrophysics Data System (ADS)

    Mazzetti, P.; Dubois, G.; Santoro, M.; Peedell, S.; de Longueville, B.; Nativi, S.; Craglia, M.

    2010-12-01

    Natural ecosystems are in rapid decline. Major habitats are disappearing at a speed never observed before. The current rate of species extinction is several orders of magnitude higher than the background rate from the fossil record. Protected Areas (PAs) and Protected Area Systems are designed to conserve natural and cultural resources, to maintain biodiversity (ecosystems, species, genes) and ecosystem services. The scientific challenge of understanding how environmental and climatological factors impact on ecosystems and habitats requires the use of information from different scientific domains. Thus, multidisciplinary interoperability is a crucial requirement for a framework aiming to support scientists. The Group on Earth Observations (or GEO) is coordinating international efforts to build a Global Earth Observation System of Systems (GEOSS). This emerging public infrastructure is interconnecting a diverse and growing array of instruments and systems for monitoring and forecasting changes in the global environment. This “system of systems” supports multidisciplinary and cross-disciplinary scientific researches. The presented GEOSS-based interoperability framework facilitates the discovery and exploitation of datasets and models from heterogeneous scientific domains and Information Technology services (data sources). The GEO Architecture and Data Committee (ADC) launched the Architecture Implementation Pilot (AIP) Initiative to develop and deploy new processes and infrastructure components for the GEOSS Common Infrastructure (GCI) and the broader GEOSS architecture. The current AIP Phase 3 (AIP-3) aims to increase GEOSS capacity to support several strategic Societal Benefit Areas (SBAs) including: Disaster Management, Health/Air Quality, Biodiversity, Energy, Health/Disease and Water. As to Biodiversity, the EC-funded EuroGEOSS (http://www.eurogeoss.eu) and GENESIS (http://www.genesis-fp7.eu) projects have developed a use scenario called

  9. EPA awards Goochland County teacher with Presidential Innovation Award

    EPA Pesticide Factsheets

    PHILADELPHIA (August 17, 2015) --The U.S. Environmental Protection Agency has awarded middle school teacher Anne Moore from the Goochland County Public Schools in Virginia with the Presidential Innovation Award for Environmental Educators (PIAEE).

  10. EPA awards Van Buren, Ark. Teacher with Presidential Innovation Award

    EPA Pesticide Factsheets

    DALLAS - (July 17, 2015) The U.S. Environmental Protection Agency has awarded Jolie Hobbs of King Elementary School in Van Buren, Ark. with the Presidential Innovation Award for Environmental Educators (PIAEE). She was honored today at a ceremony at

  11. Vannevar Bush Award

    NASA Astrophysics Data System (ADS)

    The National Science Board (NSB) has announced that nominations for the Vannevar Bush Award are now being accepted. The award is given to a scientist who has made outstanding contributions to science and technology through public service activities. Nominations are due January 1, 1985. Information and guidelines are available from the National Science Board, 1800 G St., N.W., Washington, DC 20550.The award was established in 1980 by the Science Board in commemoration of the 30th anniversary of the National Science Foundation (NSF). Vannevar Bush, acting on advice from President Roosevelt, recommended in 1945 that a foundation be established to be a focal point for the federal government's activities in science and technology. NSF was created 5 years later by Congress.

  12. NSF graduate awards

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    Of the 450 college students offered fellowships by the National Science Foundation (NSF) this year for graduate study in 1983-1984 in the natural and social sciences, mathematics, and engineering, 40 plan to pursue graduate studies in earth, ocean, or space sciences. None of the 50 science students awarded NSF minority graduate fellowship awards plans to study in the geophysics-related sciences.Each fellowship, awarded for 3 years of graduate study, provides a stipend of $6,900 per year for full-time graduate study. An annual cost-of-education allowance of $4,000 is provided by NSF in lieu of all tuition and fees to the institution selected by each fellow for graduate study. The fellowships may be used over 5 years to permit students to incorporate teaching or research assistantships into their education during periods in which they are not receiving their fellowship stipends.

  13. Ames Lab Named an Industry Safety Leader

    ScienceCinema

    Wessels, Tom

    2016-07-12

    The U.S. Department of Energy's Ames Laboratory has been named a 2010 Industry Leader Award winner by the National Safety Council. The Ames Laboratory was one of only 81 companies/organizations to receive the award for their safety performance and the only DOE national laboratory on the list. The award represents the top 5 percent of members that have qualified for the National Safety Council 2010 Occupational Excellence Achievement Award, based on 2009 calendar year data.

  14. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA Administrator Charlie Bolden holds up a photograph showing four female Astronauts onboard the Space Station during his presentation at the Women in Aerospace (WIA) organization's annual awards ceremony and banquet at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Bolden presented Women in Aerospace's Outstanding Member Award to NASA Deputy Administrator Lori Garver, noting her ongoing leadership and participation in Women in Aerospace and her passion and dedication to opening the high frontier of space to the everyday person. Photo Credit: (NASA/Bill Ingalls)

  15. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA's Associate Administrator of the Science Mission Directorate Dr. Edward J. Weiler presents the Women in Aerospace's Lifetime Achievement Award to retired NASA chief astronomer Nancy Grace Roman at the organization's annual awards ceremony and banquet held at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Four current NASA leaders and one retiree were recognized for their work by Women in Aerospace. The event celebrates women's professional excellence in aerospace and honors women who have made outstanding contributions to the aerospace community. Photo Credit: (NASA/Bill Ingalls)

  16. Women in Aerospace Awards

    NASA Image and Video Library

    2010-10-26

    NASA Langley Aerospace Engineer Jill Lynette Hanna Prince receives the Women in Aerospace Achievement in Aerospace award from North Carolina State Professor Robert Tolson during the Women in Aerospace organization's annual awards ceremony and banquet held at the Ritz-Carlton Hotel in Arlington, VA on Tuesday, Oct. 26, 2010. Four current NASA leaders and one retiree were recognized for their work by Women in Aerospace. The event celebrates women's professional excellence in aerospace and honors women who have made outstanding contributions to the aerospace community. Photo Credit: (NASA/Bill Ingalls)

  17. UK businesses bag innovation awards

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2015-09-01

    Five UK firms have received innovation awards from the Institute of Physics (IOP), which publishes Physics World. Hallmarq Veterinary Imaging, Metrasens, M Squared Lasers, Silixa and Tracerco have all won an IOP award for developing new innovative products.

  18. Stevenson received the Whipple award

    NASA Astrophysics Data System (ADS)

    Shoemaker, Eugene M.; Stevenson, David J.

    1996-02-01

    David J. Stevenson received the Whipple Award at the 1994 Spring Meeting in Baltimore. The award is given for outstanding scientific contributions to the field of planetology. The citation and Stevenson's response are given here.

  19. Coe Receives 2007 Gilbert Award

    NASA Astrophysics Data System (ADS)

    Bogue, Scott W.; Coe, Robert S.

    2008-05-01

    Robert S. Coe received the 2007 William Gilbert Award at the 2007 AGU Fall Meeting in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  20. IT Summit 2010 - Award Winners

    NASA Image and Video Library

    NASA CIO Linda Cureton announces this year’s IT Summit award winners. These awards recognize achievement in six key areas for contributions that have aided in NASA achieving mission goals and objec...

  1. 40 CFR 791.37 - The award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) DATA REIMBURSEMENT Hearing Procedures § 791.37 The award. (a) Time of award. The award shall be made... ordered reimbursement. (c) Delivery of award to parties. Parties shall accept as legal delivery of the award the delivery of the award or a true copy thereof by certified mail to the party at its last known...

  2. Global Cancer Humanitarian Award

    Cancer.gov

    Pat Garcia-Gonzalez of the Max Foundation accepted the first annual NCI Global Cancer Medicine Humanitarian Award for her work in chronic myeloid leukemia at the NCI, Center for Global Health Symposium for Global Cancer Research, held in Boston on March 25, 2015.

  3. Award Winning Science Projects.

    ERIC Educational Resources Information Center

    Showalter, Victor M.; Slesnick, Irwin L.

    This is a collection of reports of student award winning science projects that have appeared in "The Science Teacher." Grade levels 7-12 are represented with projects categorized as follows: biology, chemistry and physics, earth-space science, and miscellaneous. In each section the abstracts are arranged in order of increasing complexity…

  4. 1987 Paragon Awards.

    ERIC Educational Resources Information Center

    Golden, Sandra

    1987-01-01

    Describes the annual Paragon Award winners, representing 76 successful community college marketing efforts in the areas of overall promotion; best catalog, schedule, annual report, newsletter, news story, viewbook, brochure, poster, folder, postcard, outdoor advertising, print advertisement, radio advertisement, video promotion, photographs, media…

  5. 1987 Paragon Awards.

    ERIC Educational Resources Information Center

    Golden, Sandra

    1987-01-01

    Describes the annual Paragon Award winners, representing 76 successful community college marketing efforts in the areas of overall promotion; best catalog, schedule, annual report, newsletter, news story, viewbook, brochure, poster, folder, postcard, outdoor advertising, print advertisement, radio advertisement, video promotion, photographs, media…

  6. International Humanitarian Award.

    PubMed

    2016-11-01

    The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2016 recipient of the APA International Humanitarian Award was selected by the 2015 Committee on International Relations in Psychology (CIRP). The members of the 2015 CIRP were Rehman Abdulrehman, PhD (Chair); Gonzalo Bacigalupe, EdD; Silvia S. Canetto, PhD; Amanda Clinton, PhD; Melissa L. Morgan Consoli, PhD; Chryse G. Hatzichristou, PhD; Arpana G. Inman, PhD; Lori Foster Thompson, PhD; and Danny Wedding, PhD. Dr. Abdulrehman, Dr. Morgan Consoli, Dr. Thompson, and Dr. Wedding were members of the subcommittee for the 2016 award. (PsycINFO Database Record

  7. Presidential Teacher Award Winners

    NASA Image and Video Library

    2011-05-19

    Recipients of the Presidential Award for Excellence in Mathematics and Science Teaching stand together with NASA Administrator Charles Bolden and chief scientist Waleed Abdalati, center, at NASA Headquarters in Washington on Wednesday, May 19, 2011. Photo Credit: (NASA/Paul E. Alers)

  8. The Ogre Awards

    ERIC Educational Resources Information Center

    Davis, Enid

    2008-01-01

    In this article, the author describes the Ogre Awards, an ambitious storytelling event she developed for The Harker School during the 1996-1997 school year. Although it has evolved over these twelve years, the concept of the event is as follows: three of the four homeroom classes (averaging twenty-two students each) perform a segment of a…

  9. Representation of continuous hand and arm movements in macaque areas M1, F5, and AIP: a comparative decoding study

    NASA Astrophysics Data System (ADS)

    Menz, Veera Katharina; Schaffelhofer, Stefan; Scherberger, Hansjörg

    2015-10-01

    Objective. In the last decade, multiple brain areas have been investigated with respect to their decoding capability of continuous arm or hand movements. So far, these studies have mainly focused on motor or premotor areas like M1 and F5. However, there is accumulating evidence that anterior intraparietal area (AIP) in the parietal cortex also contains information about continuous movement. Approach. In this study, we decoded 27 degrees of freedom representing complete hand and arm kinematics during a delayed grasping task from simultaneously recorded activity in areas M1, F5, and AIP of two macaque monkeys (Macaca mulatta). Main results. We found that all three areas provided decoding performances that lay significantly above chance. In particular, M1 yielded highest decoding accuracy followed by F5 and AIP. Furthermore, we provide support for the notion that AIP does not only code categorical visual features of objects to be grasped, but also contains a substantial amount of temporal kinematic information. Significance. This fact could be utilized in future developments of neural interfaces restoring hand and arm movements.

  10. 77 FR 19408 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Federal Aviation Administration Deadline for Notification of Intent To Use the Airport Improvement Program... Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces May 1, 2012, as... Airport Improvement Program (AIP)-eligible projects that the sponsor previously identified through the...

  11. Familial isolated pituitary adenoma caused by a Aip gene mutation not described before in a family context.

    PubMed

    García-Arnés, J A; González-Molero, I; Oriola, J; Mazuecos, N; Luque, R; Castaño, J; Arraez, M A

    2013-12-01

    The cause of familial isolated pituitary adenomas (FIPA) remains unknown in a high percentage of cases, but the AIP gene plays an important role in the etiology. The aim of the study is to describe a family with FIPA syndrome and the results of genomic studies. A 16-year-old man had a giant prolactinoma resistant tomedical treatment with delayed growth and pubertal development. His mother had been previously diagnosed with a nonfunctioning pituitary macroadenoma. Transsphenoidal endoscopic resection was performed and a genetic study revealed a heterozygous mutation in exon 6: 974G>A (p.Arg325Gln). Because the AIP gene is a tumor suppressor gene, we searched for loss of heterozygosity within the AIP gene by amplifying exon 6 from tumor tissue of the patient. In the electropherogram, only the A allele was amplified (hemizygous state), indicating loss of the normal allele. We report a Spanish family with FIPA in whom a mutation in the AIP gene previously unreported in a familiar context was identified.

  12. Aggressive prolactinoma in a child related to germline mutation in the ARYL hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Naves, Luciana Ansaneli; Jaffrain-Rea, Marie-Lise; Vêncio, Sergio Alberto Cunha; Jacomini, Clausmir Zaneti; Casulari, Luiz Augusto; Daly, Adrian F; Beckers, Albert

    2010-11-01

    The objective of this study was to describe a familial screening for AIP mutations in the context of aggressive prolactinoma in childhood. A 12-year-old boy, presented headaches and bilateral hemianopsia. He had adequate height and weight for his age (50(th) percentile), Tanner stage G1 P1. His bone age was 10 years. Prolactin was 10.560 ng/mL (3-25), FSH and LH were undetectable, IGF-1, TSH, Free T4, ACTH, and cortisol were within normal ranges. MRI showed a pituitary macroadenoma, 5.3 X 4.0 X 3.5 cm with compression of the optic chiasm, bilateral cavernous sinus invasion, encasement of carotids, and extension to clivus. Surgical debulking was performed. Resistance to cabergoline was characterized and he was submitted to two surgeries and radiotherapy. Immunohistochemical evaluation included prolactin, ACTH, GH, FSH, LH,AIP, c-erb B2, Ki-67, and p53. Genomic DNA was isolated from the index case and 48 relatives, PCR and sequencing were performed.A germline A195V mutation in AIP was identified in the index case and in five asymptomatic relatives. Germline mutations in the AIP gene may be involved in the predisposition to pituitary adenoma formation, as cause or co-factor in pathogenesis of aggressive tumors in young patients.

  13. Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.

    PubMed

    Radian, Serban; Diekmann, Yoan; Gabrovska, Plamena; Holland, Brendan; Bradley, Lisa; Wallace, Helen; Stals, Karen; Bussell, Anna-Marie; McGurren, Karen; Cuesta, Martin; Ryan, Anthony W; Herincs, Maria; Hernández-Ramírez, Laura C; Holland, Aidan; Samuels, Jade; Aflorei, Elena Daniela; Barry, Sayka; Dénes, Judit; Pernicova, Ida; Stiles, Craig E; Trivellin, Giampaolo; McCloskey, Ronan; Ajzensztejn, Michal; Abid, Noina; Akker, Scott A; Mercado, Moises; Cohen, Mark; Thakker, Rajesh V; Baldeweg, Stephanie; Barkan, Ariel; Musat, Madalina; Levy, Miles; Orme, Stephen M; Unterländer, Martina; Burger, Joachim; Kumar, Ajith V; Ellard, Sian; McPartlin, Joseph; McManus, Ross; Linden, Gerard J; Atkinson, Brew; Balding, David J; Agha, Amar; Thompson, Chris J; Hunter, Steven J; Thomas, Mark G; Morrison, Patrick J; Korbonits, Márta

    2017-01-01

    The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) (or p.R304(*) ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304(*) carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011-0.0047) and zero in ROI (0-0.0014). R304(*) prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P < 0.05), but not in ROI (2/29, 6.8%) versus non-Irish patients (0-2.41%). Haploblock conservation supported a common ancestor for all the 18 identified Irish pedigrees (81 carriers, 30 affected). Time to most recent common ancestor (tMRCA) was 2550 (1,275-5,000) years. tMRCA-based simulations predicted 432 (90-5,175) current carriers, including 86 affected (18-1,035) for 20% penetrance. In conclusion, R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP-related disease.

  14. Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene

    PubMed Central

    Aaltonen, Lauri A.; Daly, Adrian F.

    2013-01-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  15. Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Beckers, Albert; Aaltonen, Lauri A; Daly, Adrian F; Karhu, Auli

    2013-04-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  16. Langley Medal awarded

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    Robert Thomas Jones, senior scientist at the Ames Research Center, Mountain View, Calif., was awarded the distinguished Langley Medal by the Smithsonian Institution for his ‘extensive contributions in theoretical aerodynamics, particularly with regard to development of the swept wing, supersonic area rule and, more recently, the oblique wing.’ Jones is an internationally acclaimed expert on aerodynamics, optics, and biomechanics as well as an applied mathematician, astronomer, inventor, author, and violin maker.The Langley award has been given to just 16 recipients since it was established 73 years ago. Past recipients include Wilbur and Orville Wright, Charles Lindbergh, and Richard Byrd. Named for Samuel Pierpont Langley, aeronautical pioneer and third secretary of the Smithsonian, the medal honors ‘especially meritorious investigations in the field of aerospace science.’

  17. Holcim, Inc. Receives Gulf Guardian Award for Eliminating Stormwater Discharges from Theodore, Ala.

    EPA Pesticide Factsheets

    ATLANTA - The U.S. Environmental Protection Agency's (EPA) Gulf of Mexico Program recognized Holcim Inc., which operates a cement plant in Theodore, Ala., with the First Place 2015 Gulf Guardian Award in the Business and Industry Category. The awards cerem

  18. 34 CFR 472.2 - Who is eligible for an award?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... eligible for an award? (a) Awards are provided to exemplary partnerships between— (1) A business, industry... partners at least one entity from paragraph (a)(1) of this section and at least one entity from paragraph (a)(2) of this section, and may include more than one entity from each group. (c)(1) The...

  19. 31 CFR 20.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Award. 20.605 Section 20.605 Money...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.605 Award. Award means an award of financial... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in...

  20. 31 CFR 20.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Award. 20.605 Section 20.605 Money...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.605 Award. Award means an award of financial... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in...

  1. 31 CFR 20.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Award. 20.605 Section 20.605 Money...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.605 Award. Award means an award of financial... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in...

  2. 31 CFR 20.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Award. 20.605 Section 20.605 Money...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.605 Award. Award means an award of financial... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in...

  3. 31 CFR 20.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Award. 20.605 Section 20.605 Money...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.605 Award. Award means an award of financial... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in...

  4. Hutchinson Award to Eville Gorham

    NASA Astrophysics Data System (ADS)

    Nixon, Scott W.

    Eville Gorham, Regents Professor of Ecology and Botany at the University of Minnesota, is the 1986 recipient of the Hutchinson Award. The medallion and certificate that constitute the award are given annually by the American Society of Limnology and Oceanography (ASLO) in recognition of outstanding research. The award was presented to Gorham by G.E. Hutchinson (Yale University, New Haven, Conn.) at a banquet in Newport, R.I., during the ASLO summer meeting.

  5. NCI R25T Award

    Cancer.gov

    Institutional award for predoctoral or postdoctoral candidates or mentored junior faculty who are pursuing careers in cancer prevention, control, behavioral, and population sciences or transdisciplinary sciences.

  6. USP8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

    PubMed Central

    Panner, Amith; Crane, Courtney A.; Weng, Changjiang; Feletti, Alberto; Fang, Shanna; Parsa, Andrew T.; Pieper, Russell O.

    2010-01-01

    The anti-apoptotic protein FLIPS is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homolog (PTEN)-Akt-atrophin interacting protein 4 (AIP4) pathway regulates FLIPS ubiquitination and stability, although the means by which PTEN and Akt were linked to AIP4 activity were unclear. We here report that a second regulator of ubiquitin metabolism, the ubiquitin-specific protease (USP) 8, is a downstream target of Akt, and that USP8 links Akt to AIP4 and the regulation of FLIPS stability and TRAIL resistance. In human GBM xenografts, levels of USP8 correlated inversely with pAkt levels, and genetic or pharmacologic manipulation of Akt regulated USP8 levels in an inverse manner. Over-expression of WT USP8, but not catalytically inactive USP8, increased FLIPS ubiquitination, decreased FLIPS half-life, decreased FLIPS steady-state levels, and decreased TRAIL resistance, while siRNA-mediated suppression of USP8 levels had the opposite effects. Because high levels of the USP8 deubiquitinase correlated with high levels of FLIPS ubiquitination, USP8 appeared to control FLIPS ubiquitination through an intermediate target. Consistent with this idea, over-expression of WT USP8 decreased ubiquitination of the FLIPS E3 ubiquitin ligase AIP4, an event previously shown to increase AIP4-FLIPS interaction, while siRNA-mediated suppression of USP8 increased AIP4 ubiquitination. Furthermore, the suppression of FLIPS levels by USP8 over-expression was reversed by introduction of siRNA targeting AIP4. These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIPS stability and TRAIL sensitivity. PMID:20484045

  7. Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.

    PubMed Central

    Amberg, D C; Zahner, J E; Mulholland, J W; Pringle, J R; Botstein, D

    1997-01-01

    A search for Saccharomyces cerevisiae proteins that interact with actin in the two-hybrid system and a screen for mutants that affect the bipolar budding pattern identified the same gene, AIP3/BUD6. This gene is not essential for mitotic growth but is necessary for normal morphogenesis. MATa/alpha daughter cells lacking Aip3p place their first buds normally at their distal poles but choose random sites for budding in subsequent cell cycles. This suggests that actin and associated proteins are involved in placing the bipolar positional marker at the division site but not at the distal tip of the daughter cell. In addition, although aip3 mutant cells are not obviously defective in the initial polarization of the cytoskeleton at the time of bud emergence, they appear to lose cytoskeletal polarity as the bud enlarges, resulting in the formation of cells that are larger and rounder than normal. aip3 mutant cells also show inefficient nuclear migration and nuclear division, defects in the organization of the secretory system, and abnormal septation, all defects that presumably reflect the involvement of Aip3p in the organization and/or function of the actin cytoskeleton. The sequence of Aip3p is novel but contains a predicted coiled-coil domain near its C terminus that may mediate the observed homo-oligomerization of the protein. Aip3p shows a distinctive localization pattern that correlates well with its likely sites of action: it appears at the presumptive bud site prior to bud emergence, remains near the tips of small bund, and forms a ring (or pair of rings) in the mother-bud neck that is detectable early in the cell cycle but becomes more prominent prior to cytokinesis. Surprisingly, the localization of Aip3p does not appear to require either polarized actin or the septin proteins of the neck filaments. Images PMID:9247651

  8. Aryl Hydrocarbon Receptor-Interacting Protein (AIP) N-Terminus Gene Mutations Identified in Pituitary Adenoma Patients Alter Protein Stability and Function.

    PubMed

    Formosa, Robert; Vassallo, Josanne

    2017-03-02

    Mutations spanning the entire aryl hydrocarbon receptor-interacting protein (AIP) gene have been found in isolated familial cases of pituitary adenomas (PA). Missense mutations located in the N-terminus of the gene have been identified in several patients. However, the functional significance of these mutations remains a matter of controversy. In most studies, the N-terminus of AIP has been shown to regulate protein stability and subcellular localization of the AIP-AHR-HSP90 complex but not to be involved in protein-protein interactions. Other studies found that the N-terminal domain interacts directly with other proteins. The aim of this study was to analyze whether specific N-terminus AIP mutations identified in PA patients would be functionally different from wild-type (WT) AIP. In vitro analyses were used to assess the role of known N-terminus variants, a locally identified mutant, R9Q, and three other commonly genotyped N-terminus mutations R16H, V49M and K103R are found in PA patients. Given the functional effect of WT AIP on cAMP signalling alterations caused by N-terminus mutants on this pathway were also analyzed in GH3 cells. Results indicate that N-terminus mutations lead to de-regulation of the effect of WT AIP on cAMP signalling and increased cAMP thresholds in GH3 cells resulting in increased growth hormone (GH) secretion. Cycloheximide chase analysis identified a variation in protein degradation patterns between WT and N-terminus variants. Therefore, both functional and structural studies reveal that N-terminus mutations in the AIP gene alter protein behaviour significantly and hence can truly be pathogenic in nature.

  9. Advanced Information Processing System (AIPS) proof-of-concept system functional design I/O network system services

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The function design of the Input/Output (I/O) services for the Advanced Information Processing System (AIPS) proof of concept system is described. The data flow diagrams, which show the functional processes in I/O services and the data that flows among them, are contained. A complete list of the data identified on the data flow diagrams and in the process descriptions are provided.

  10. Functions of early (AP-2) and late (AIP1/ALIX) endocytic proteins in equine infectious anemia virus budding.

    PubMed

    Chen, Chaoping; Vincent, Olivier; Jin, Jing; Weisz, Ora A; Montelaro, Ronald C

    2005-12-09

    The proline-rich L domains of human immunodeficiency virus 1 (HIV-1) and other retroviruses interact with late endocytic proteins during virion assembly and budding. In contrast, the YPDL L domain of equine infectious anemia virus (EIAV) is apparently unique in its reported ability to interact both with the mu2 subunit of the AP-2 adaptor protein complex and with ALG-2-interacting protein 1 (AIP1/Alix) protein factors involved in early and late endosome formation, respectively. To define further the mechanisms by which EIAV adapts vesicle trafficking machinery to facilitate virion production, we have examined the specificity of EIAV p9 binding to endocytic factors and the effects on virion production of alterations in early and late endocytic protein expression. The results of these studies demonstrated that (i) an approximately 300-residue region of AIP1/Alix-(409-715) was sufficient for binding to the EIAV YPDL motif; (ii) overexpression of AIP1/Alix or AP-2 mu2 subunit specifically inhibited YPDL-mediated EIAV budding; (iii) virion budding from a replication-competent EIAV variant with its L domain replaced by the HIV PTAP sequence was inhibited by wild type or mutant mu2 to a level similar to that observed when a dominant-negative mutant of Tsg101 was expressed; and (iv) overexpression or siRNA silencing of AIP1/Alix and AP-2 revealed additive suppression of YPDL-mediated EIAV budding. Taken together, these results indicated that both early and late endocytic proteins facilitate EIAV production mediated by either YPDL or PTAP L domains, suggesting a comprehensive involvement of endocytic factors in retroviral assembly and budding that can be accessed by distinct L domain specificities.

  11. 1993 architectural design awards.

    PubMed

    1993-06-01

    The 10th annual architectural design awards sponsored by Contemporary Long Term Care salute nursing homes and retirement communities that combine a flair for innovative living environments with a sensitivity to the needs of aging residents. These facilities represent the very best in elderly housing that prolongs independence while enhancing efficient operation. The 1993 winners are: King Health Center, U.S. Soldiers' and Airmen's Home, Washington, DC; The Terrace of Los Gatos, Los Gatos, CA; Walker Elder Suites, Edina, MN; The Jefferson, Ballston, VA; The Forum at Rancho San Antonio, Cupertino, CA.

  12. Outstanding student paper awards

    NASA Astrophysics Data System (ADS)

    Six Outstanding Student Paper awards were given in the Space Physics and Aeronomy Section at the AGU Spring Meeting, held last May in Baltimore, Md.David Walthour, who presented “Satellite Data Analysis of Two-Dimensional Magnetopause Structures,” is a doctoral student at the Thayer School of Engineering, Dartmouth College. He received a B.S. in electrical engineering from the University of Cincinnati. His research interests include field-aligned MHD flows, the development of data analysis techniques for examining transient events at the Earth magnetopause, and the study of anomalous MHD wave properties in anisotropic plasmas with application to reconnection.

  13. Beni Solow Award 2014.

    PubMed

    2015-08-01

    The Beni Solow award for the best article published in the European Journal of Orthodontics in 2014 has been won by: Karoline Dreesen, Steven Swinnen, Koenraad Devriendt, and Carine Carels from Departments of Orthodontics and Human Genetics, Katholieke Universiteit Leuven, Belgium and Department of Orthodontics and Craniofacial Biology, Radboud University Nijmegen Medical Centre, the Netherlands for their article ‘Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees’ Eur J Orthod 2014 36(1), 99–106. This article can be accessed free of charge online at: www.ejo.oxfordjournals. org.

  14. Outstanding student paper awards

    NASA Astrophysics Data System (ADS)

    The Hydrology Section presented six outstanding student paper awards at the 2000 AGU Spring Meeting in Washington, D.C., last June.Wade T. Crow presented a poster titled Impacts of Upscaling Soil Moisture During SGP 97. He received a B.A. in physics from Carleton College in 1995, and a M.S.E.in civil and environmental engineering from Princeton University in 1998. Wade is currently completing his Ph.D. at Princeton. His dissertation work, supervised by Eric F Wood, focuses on spatial scale issues surrounding both the retrieval of soil moisture imagery by microwave remote sensors and the eventual assimilation of this imagery into hydrologic models.

  15. NASA SAVE Award Winner

    NASA Image and Video Library

    2012-01-09

    NASA Goddard Space Flight Center Financial Manager and White House 2011 SAVE award winner Matthew Ritsko is seen during a television interview at NASA Headquarters shortly after meeting with President Obama at the White House on Monday, Jan. 9, 2011, in Washington. The Presidential Securing Americans' Value and Efficiency (SAVE) program gives front-line federal workers the chance to submit their ideas on how their agencies can save money and work more efficiently. Matthew's proposal calls for NASA to create a "lending library" where specialized space tools and hardware purchased by one NASA organization will be made available to other NASA programs and projects. Photo Credit: (NASA/Bill Ingalls)

  16. Outstanding Student Paper Awards

    NASA Astrophysics Data System (ADS)

    2004-04-01

    The following members in the Space Physics & Aeronomy Section received Outstanding Student Paper Awards at the 2003 AGU Fall Meeting in San Francisco, California. Arve Aksnes; Aroh Barjatya; Jacob Bortnik; Amir Caspi; Ruben Delgado; Galen Fowler; Paul G. Hanlon; Sid Henderson; Tara B. Hiebert; Chia-Lin Huang; Steven P. Joy; Eun-Hwa Kim; Colby Lemon; Yingjuan Ma; Elizabeth A. MacDonald; Jaco Minnie; Mitsuo Oka; Yoshitaka Okazaki; Erin J. Rigler; Ina P. Robertson; Patrick A. Roddy; Sang-Il Roh; Albert Y. Shih; Christopher Smithtro; Emma Spanswick; Maria Spasojevic; Hiroki Tanaka; Linghua Wang; Deirdre E. Wendel; Jichun Zhang>

  17. Outstanding Student Paper Awards

    NASA Astrophysics Data System (ADS)

    2003-01-01

    The following members in the Space Physics & Aeronomy Section received Outstanding Student Paper Awards at the 2003 AGU Fall Meeting in San Francisco, California. Arve Aksnes; Aroh Barjatya; Jacob Bortnik; Amir Caspi; Ruben Delgado; Galen Fowler; Paul G. Hanlon; Sid Henderson; Tara B. Hiebert; Chia-Lin Huang; Steven P. Joy; Eun-Hwa Kim; Colby Lemon; Yingjuan Ma; Elizabeth A. MacDonald; Jaco Minnie; Mitsuo Oka; Yoshitaka Okazaki; Erin J. Rigler; Ina P. Robertson; Patrick A. Roddy; Sang-Il Roh; Albert Y. Shih; Christopher Smithtro; Emma Spanswick; Maria Spasojevic; Hiroki Tanaka; Linghua Wang; Deirdre E. Wendel; Jichun Zhang>

  18. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

    PubMed Central

    Silva, Daniela S.; Pereira, Liliana M. G.; Moreira, Ana R.; Ferreira-da-Silva, Frederico; Brito, Rui M.; Faria, Tiago Q.; Zornetta, Irene; Montecucco, Cesare; Oliveira, Pedro; Azevedo, Jorge E.; Pereira, Pedro J. B.; Macedo-Ribeiro, Sandra; do Vale, Ana; dos Santos, Nuno M. S.

    2013-01-01

    AIP56 (apoptosis-inducing protein of 56 kDa) is a major virulence factor of Photobacterium damselae piscicida (Phdp), a Gram-negative pathogen that causes septicemic infections, which are among the most threatening diseases in mariculture. The toxin triggers apoptosis of host macrophages and neutrophils through a process that, in vivo, culminates with secondary necrosis of the apoptotic cells contributing to the necrotic lesions observed in the diseased animals. Here, we show that AIP56 is a NF-κB p65-cleaving zinc-metalloprotease whose catalytic activity is required for the apoptogenic effect. Most of the bacterial effectors known to target NF-κB are type III secreted effectors. In contrast, we demonstrate that AIP56 is an A-B toxin capable of acting at distance, without requiring contact of the bacteria with the target cell. We also show that the N-terminal domain cleaves NF-κB at the Cys39-Glu40 peptide bond and that the C-terminal domain is involved in binding and internalization into the cytosol. PMID:23468618

  19. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    NASA Astrophysics Data System (ADS)

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-10-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  20. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.

    PubMed

    Barucker, Christian; Bittner, Heiko J; Chang, Philip K-Y; Cameron, Scott; Hancock, Mark A; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W; McKinney, R Anne; Multhaup, Gerhard

    2015-10-29

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically "trapping" low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  1. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    PubMed Central

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-01-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal. PMID:26510576

  2. Presidential Green Chemistry Challenge: 2015 Specific Environmental Benefit: Climate Change Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2015 award winner, Algenol, blue-green algae to produce ethanol and other fuels, uses CO2 from air or industrial emitters, reduces the carbon footprint, costs and water usage, no reliance on food crops

  3. NASA Invention of the year Award - 2004. The revolutionary unique braided carbon-fiber thermal barr

    NASA Technical Reports Server (NTRS)

    2005-01-01

    NASA Invention of the year Award - 2004. The revolutionary unique braided carbon-fiber thermal barrier is designed to with stand the extreme temperature environments in current and future solid rocket motors with application to industrial equipment

  4. Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

    PubMed

    Fisher, Robert D; Chung, Hyo-Young; Zhai, Qianting; Robinson, Howard; Sundquist, Wesley I; Hill, Christopher P

    2007-03-09

    ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form elongated arms that fold back into a "V." The structures also reveal conformational flexibility in the arms that suggests that the V domain may act as a flexible hinge in response to ligand binding. YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of the V, whereas CHMP4/ESCRT-III proteins bind a conserved hydrophobic patch on the Bro1 domain, and both interactions are required for virus budding. ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery.

  5. John P. Campbell: award for distinguished scientific applications of psychology.

    PubMed

    2006-11-01

    Presents the citation for John P. Campbell who received Award for Distinguished Scientific Applications of Psychology "for his many different contributions to the field of industrial and organizational (I/O) psychology." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved).

  6. 48 CFR 19.1306 - HUBZone sole source awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false HUBZone sole source awards. 19.1306 Section 19.1306 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION..., will not exceed— (i) $6.5 million for a requirement within the North American Industry Classification...

  7. 40 CFR 35.418 - Award limitations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (section 205(j)(2)) § 35.418 Award limitations. The following limitations apply to funds awarded under section 205(j)(2) of the Clean Water Act. The Regional Administrator will not award these grants to...

  8. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.

    PubMed

    Nukaya, Manabu; Lin, Bernice C; Glover, Edward; Moran, Susan M; Kennedy, Gregory D; Bradfield, Christopher A

    2010-11-12

    The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development. In our model of AHR signaling, the receptor is found in a cytosolic complex with a number of molecular chaperones, including Hsp90, p23, and the aryl hydrocarbon receptor-interacting protein (AIP), also known as ARA9 and XAP2. To understand the role of AIP in adaptive and toxic aspects of AHR signaling, we generated a conditional mouse model where the Aip locus can be deleted in hepatocytes. Using this model, we demonstrate two important roles for the AIP protein in AHR biology. (i) The expression of AIP in hepatocytes is essential to maintain high levels of functional cytosolic AHR protein in the mammalian liver. (ii) Expression of the AIP protein is essential for dioxin-induced hepatotoxicity. Interestingly, classical AHR-driven genes show differential dependence on AIP expression. The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not. This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.

  9. ASLO Presents Hutchinson Award

    NASA Astrophysics Data System (ADS)

    Lawrence Richards Pomeroy, Alumni Foundation Distinguished Professor at the University o f Georgia, Athens, is the 1987 recipient of the Hutchinson Award, given annually by the American Society of Limnology and Oceanography (ASLO). The award is given in recognition o f outstanding past and current research in limnology and oceanography.Larry Pomeroy was trained in zoology at the University of Michigan, where he received his B.S. and M.S., and at Rutgers University, where he received his Ph.D. in 1959. In his very first published research, on phosphorus uptake by the American oyster, he began the interest in phosphorus and mineral cycling in natural waters that was to be a major research theme o f his for the next 20 years. His studies at the University of Georgia included measurements of estuaries, coral reefs, zooplankton excretion, salt marshes, and sediment-water exchange. The techniques and understanding that he developed and the publications he produced with a variety of coauthors made him a world leader in the biogeochemistry of phosphorus cycling.

  10. Outstanding student paper awards

    NASA Astrophysics Data System (ADS)

    The Atmospheric Sciences Section presented the following outstanding student paper awards at the AGU 1997 Fall Meeting in San Francisco, California, last December. James Corbett presented a poster on “Nitrogen and Sulfur Emissions From Oceangoing Ships.” James is a Ph.D. candidate in the Department of Engineering and Public Policy (EPP) at Carnegie Mellon University, Pittsburgh, Pa. He has been awarded a M.S. degree in EPP and recently completed the M.S. requirements in the Department of Mechanical Engineering. He graduated in 1985 with a degree in marine engineering technology from the California Maritime Academy and holds a California Professional Engineering License (Mechanical). He joined the doctoral program in engineering and public policy at Carnegie Mellon University in August 1995. In 1997, he was selected for a U.S. EPA STAR Fellowship. His research focuses on international maritime transportation and pollution issues, particularly air emissions from ship propulsion. James has developed the first global geographic characterization of air emissions from international maritime transport. As recently published in Science (Corbett and Fischbeck, 1997), his work estimates the global annual nitrogen and sulfur emissions from ships to be 3.08 terragrams (Tg) N and 4.24 Tg S, respectively.

  11. Molecules Best Paper Award 2013.

    PubMed

    McPhee, Derek J

    2013-02-05

    Molecules has started to institute a "Best Paper" award to recognize the most outstanding papers in the area of natural products, medicinal chemistry and molecular diversity published in Molecules. We are pleased to announce the second "Molecules Best Paper Award" for 2013.

  12. Step 5: Award Negotiation & Issuance

    Cancer.gov

    Before a grant can be awarded and accepted, several pre-award activities must happen to formalize the partnership. Ensuring compliance with federal laws, a review of costs and a negotiation of the appropriate funding level must all happen in order to rece

  13. Step 4: Award Negotiation & Issuance

    Cancer.gov

    Before a grant can be awarded and accepted, several pre-award activities must happen to formalize the partnership. Ensuring compliance with federal laws, a review of costs and a negotiation of the appropriate funding level must all happen in order to rece

  14. Four New SPORE Grants Awarded.

    PubMed

    2015-12-01

    Despite an economic climate shaped by tight budgets, the NCI recently announced four new Specialized Program of Research Excellence awards that emphasize translation research. In total, the NCI doled out $106 million to fund these new awards and 48 renewed or continuing grants.

  15. Clark Receives Ocean Sciences Award

    NASA Astrophysics Data System (ADS)

    Roman, Michael R.; Clark, H. Lawrence

    2008-09-01

    H. Lawrence Clark received the 2008 Ocean Sciences Award at the 2008 Ocean Sciences Meeting, held 2-7 March 2008 in Orlando, Fla. The award is given in recognition of outstanding and long-standing service to the ocean sciences.

  16. Campus Technology Innovators Awards 2010

    ERIC Educational Resources Information Center

    Lloyd, Meg; Raths, David

    2010-01-01

    Each year in judging the Campus Technology Innovators awards, the authors have the privilege of reading through hundreds of fascinating examples of technology innovation on campus. Nominated projects cover the gamut of technology areas, from assessment and advising to wireless and web 2.0. This article presents 11 innovator award winners of this…

  17. The Colorado Children's Book Award.

    ERIC Educational Resources Information Center

    Livo, Norma J.

    This paper discusses the Colorado Children's Book Award (CCBA), established in 1975 to allow children, rather than adults, to vote on their favorite books. The rules for book nomination and voting are explained in this paper and a short history of the award is given. The remaining portion of the paper reviews briefly each of the 12 children's…

  18. Campus Technology Innovators Awards 2010

    ERIC Educational Resources Information Center

    Lloyd, Meg; Raths, David

    2010-01-01

    Each year in judging the Campus Technology Innovators awards, the authors have the privilege of reading through hundreds of fascinating examples of technology innovation on campus. Nominated projects cover the gamut of technology areas, from assessment and advising to wireless and web 2.0. This article presents 11 innovator award winners of this…

  19. Directory of Awards. FY 1986.

    ERIC Educational Resources Information Center

    National Science Foundation, Washington, DC. Directorate for Science and Engineering Education.

    The National Science Foundation (NSF) provides awards for education and research in the sciences, mathematics, and engineering. This publication contains information on fiscal year 1986 awards. An introductory section reviews the goals of NSF's education program and the long-range goals of the Directorate for Science and Engineering Education.…

  20. Environmental Protection Agency Award Recipient Responsibilities

    EPA Pesticide Factsheets

    Itemized Award Phase information. Information about the Recipient's Responsibilities Upon Notification of the Award, The EPA Project Officer Responsibilities, and EPA Grant Specialists Responsibilities.

  1. Award-Winning Books: A Selected List for Teens.

    ERIC Educational Resources Information Center

    Dayton, Sandra

    1984-01-01

    Lists adolescent fiction and nonfiction titles that received Boston Globe/Horn Book Award, Carnegie Medal, Child Study Children's Book Committee at Bank Street College Award, Christopher Award, Edgar Allen Poe Award, Golden Kite Award, Nebula Award, and National Book Award/American Book Award. Each entry includes bibliographic information and…

  2. Award-Winning Books: A Selected List for Teens.

    ERIC Educational Resources Information Center

    Dayton, Sandra

    1984-01-01

    Lists adolescent fiction and nonfiction titles that received Boston Globe/Horn Book Award, Carnegie Medal, Child Study Children's Book Committee at Bank Street College Award, Christopher Award, Edgar Allen Poe Award, Golden Kite Award, Nebula Award, and National Book Award/American Book Award. Each entry includes bibliographic information and…

  3. Focus awards 2002.

    PubMed

    Davis, Naomi

    2003-03-22

    The dental team at Zetland House Clinic are a particularly innovative group. As a result of their parent hospital being the first to complete a whole organization clinical governance programme run by the NHS Modernization Agency, they were consequently the first dental team to do so. Now the clinic is a better place to work where the staff are proud of their clinic and the work that they do. The changes that resulted through their experiences of the program have benefited the patients and staff alike, and was such a success story that they have been taken as an example for the Modernisation Agency website to illustrate good practice in clinical governance. These changes and the way they approached their involvement in the program also earned the Zetland House team a place on the finalist list of the 2002 Focus Awards.

  4. Prestigious award for SOHO

    NASA Astrophysics Data System (ADS)

    2003-09-01

    SOHO spacecraft artist's impression hi-res Size hi-res: 451 Kb Credits: ESA SOHO spacecraft SOHO is a project of international cooperation between ESA and NASA. SOHO's science ranges from the Sun's hot interior, through its visible surface and stormy atmosphere, and out to distant regions where the wind from the Sun battles with a breeze of atoms coming from among the stars. The award recognises both the outstanding achievements in designing, building and operating the mission, as well as the science it has performed. It is a tribute to a team that has contributed to one of the most successful space missions in history. The International Academy of Astronautics presents this award in recognition of extraordinary performance and achievement by teams of scientists, engineers and managers in the field of astronautics. This honour has been awarded only twice before - to the Russian Mir Space Station Team and the US Space Shuttle Team. Now the SOHO team joins this select group. The citation of the award for the SOHO team reads: "To the team of scientists, engineers and managers for the development and operation of a world-class mission leading to substantial advancements in understanding the Sun and the solar-terrestrial relationship." SOHO has an impressive and unique list of achievements. For instance, it produced the first ever images of the turbulent outer shell of the Sun and of the structure below sunspots. It gave the most precise measurements of the solar temperature structure, the interior rotation and the gas flows inside the Sun. It measured the acceleration of the fast and slow solar winds and discovered new solar phenomena, such as solar tornadoes. It revolutionised our ability to forecast space weather, and helped our understanding of the impact of solar variability on Earth's climate. During eight years of operation, the team has had to face several heart-stopping moments, but with extraordinary team spirit, skill and competence, they turned these

  5. A fatal case of acute interstitial pneumonia (AIP) in a woman affected by glioblastoma.

    PubMed

    Balzarini, Laura; Mancini, Chiara; Marvisi, Maurizio

    2014-03-01

    This report presents the case of a 67-year-old woman affected by glioblastoma. After a few days of adjuvant therapy with temozolomide and prophylaxis with trimetrophin-sulfamethoxazolo to prevent Pneumocystis Jiroveci, she had progressive and rapid worsening of symptoms with weakness, dyspnea and orthopnea. She had peripheral edema and proximal hyposthenia of the lower limbs. Chest CT showed bilateral ground-glass opacities and laboratory exams revealed hypoxemia and hypocapnia, an initial reduction in platelet and white blood cells, and an elevation of LDH, AST, ALT, and active urinary sediment. Blood cultures, bronchoalveolar lavage (BAL) data and transbronchial biopsy showed no infections, and in particular no evidence of Pneumocystis Jiroveci pneumonia. Histological examination revealed a typical pattern of AIP. She was treated with broad-spectrum antibiotics and high-dose steroids. The symptoms worsened and respiratory failure required mechanical ventilation. The pneumonia was not responsive to medical or invasive care. She died after ten days of hospitalization. At present very little can be found in the literature about lung toxicity caused by temozolomide. This case can be added as a new report describing this risk. The combination therapy with temozolamide and trimetophin-sulfamethoxazolo could have a synergistic action inducing various forms of pulmonary toxicity. ESTABLISHED FACTS: Acute interstitial pneumonia is a common manifestation of lung toxicity caused by drugs. The clinical course is favorable with a good response to corticosteroids. NOVEL INSIGHT: This is the first fatal case of lung toxicity caused by Temozolomide. Clinicians must be aware that a combination therapy including trimetophin-sulfamethoxazolo could have a synergistic action in inducing pulmonary toxicity.

  6. George M. Low Trophy: NASA's quality and excellence award

    NASA Technical Reports Server (NTRS)

    1991-01-01

    NASA's major goal is the preservation of America's position as a leader in the aerospace industry. To maintain that status, it is crucial that the products and services we depend upon from NASA contractors, subcontractors, and suppliers meet the highest quality standards to ensure the space program's success. The George M. Low Trophy: NASA's Quality and Excellence Award is the result of NASA's desire to encourage continuous improvement and Total Quality Management (TQM) in the aerospace industry and is awarded to members of NASA's contractor community that have demonstrated sustained excellence, customer orientation, and outstanding achievements in a Total Quality Management (TQM) environment. The purpose in presenting this award is to increase public awareness of the importance of quality and productivity to the nation's aerospace industry and the nation's leadership position overall; encourage domestic business to continuously pursue efforts that enhance quality and increase productivity which will strengthen the nation's competitiveness in the international arena; and provide a forum for sharing the successful techniques and strategies used by applicants with other American organizations. Awards to Rockwell International and Marotta Scientific Controls, Inc. are announced and discussed.

  7. The Pepper RING-Type E3 Ligase, CaAIP1, Functions as a Positive Regulator of Drought and High Salinity Stress Responses.

    PubMed

    Park, Chanmi; Lim, Chae Woo; Lee, Sung Chul

    2016-10-01

    Plant adaptive responses to osmotic stress are co-ordinated by restriction of growth and developmental processes and by molecular and physiological activities. The phytohormone ABA is the primary regulator that induces and responds to osmotic stress, and its sensitivity markedly influences osmotic stress tolerance levels. Several E3 ubiquitin ligases act as positive or negative regulators of ABA, thereby mediating sensitivity to osmotic stress in higher plants. Here, we report that the C3H2C3-type RING finger E3 ligase, CaAIP1, regulates osmotic stress responses via ABA-mediated signaling. CaAIP1 contains a RING finger motif, which functions during attachment of ubiquitins to the target proteins. Expression of CaAIP1 was induced by ABA, drought and NaCl treatments, suggesting its role in the osmotic stress response. CaAIP1-silenced pepper plants displayed a drought-sensitive phenotype characterized by a high level of transpirational water loss in the drought-treated leaves. CaAIP1-overexpressing (OX) plants exhibited increased sensitivity to ABA, but an NaCl- and mannitol-tolerant phenotype during seed germination and seedling growth. CaAIP1-OX plants further displayed enhanced tolerance to drought stress, characterized by low levels of transpirational water loss via increased stomatal closure and leaf temperature. Our data indicate that CaAIP1 is a positive regulator of the osmotic stress tolerance mechanism. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  8. John Hanson is awarded the 2016 De Florez Award

    NASA Image and Video Library

    2015-12-02

    John Hanson, Alternate Lead Systems Engineer in the Spacecraft and Vehicle Systems department of the Engineering Directorate at MSFC has been honored by the American Institute of Aeronautics and Astronautics (AIAA) with the 2016 De Florez Award for flight simulation

  9. 24 CFR 21.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Award. 21.605 Section 21.605 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.605 Award. Award means an award...

  10. 40 CFR 791.37 - The award.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false The award. 791.37 Section 791.37...) DATA REIMBURSEMENT Hearing Procedures § 791.37 The award. (a) Time of award. The award shall be made promptly by the hearing officer and, unless otherwise agreed by the parties, no later than 30 days from the...

  11. 40 CFR 791.37 - The award.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false The award. 791.37 Section 791.37...) DATA REIMBURSEMENT Hearing Procedures § 791.37 The award. (a) Time of award. The award shall be made promptly by the hearing officer and, unless otherwise agreed by the parties, no later than 30 days from the...

  12. 40 CFR 791.37 - The award.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false The award. 791.37 Section 791.37...) DATA REIMBURSEMENT Hearing Procedures § 791.37 The award. (a) Time of award. The award shall be made promptly by the hearing officer and, unless otherwise agreed by the parties, no later than 30 days from the...

  13. 40 CFR 791.37 - The award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false The award. 791.37 Section 791.37...) DATA REIMBURSEMENT Hearing Procedures § 791.37 The award. (a) Time of award. The award shall be made promptly by the hearing officer and, unless otherwise agreed by the parties, no later than 30 days from the...

  14. 42 CFR 66.206 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Grant awards. 66.206 Section 66.206 Public Health... NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.206 Grant awards. (a) Within the limits of funds available, the Secretary shall award grants to those applicants: (1) Whose applications have been reviewed...

  15. 29 CFR 1472.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1472.605 Award. Award means an award of financial.... (a) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  16. 29 CFR 1472.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1472.605 Award. Award means an award of financial.... (a) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  17. 45 CFR 630.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.605 Award. Award means an award of...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  18. 38 CFR 48.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 48.605 Award. Award means an award of.... (a) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  19. 45 CFR 630.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.605 Award. Award means an award of...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  20. 32 CFR 26.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 26.605 Award. Award means an award of... award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the grant...

  1. 45 CFR 630.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.605 Award. Award means an award of...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  2. 38 CFR 48.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 48.605 Award. Award means an award of.... (a) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  3. 24 CFR 21.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Award. 21.605 Section 21.605 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.605 Award. Award means an award...

  4. 29 CFR 1472.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Award. 1472.605 Section 1472.605 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1472.605 Award. Award means an award of financial...

  5. 28 CFR 83.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Award. 83.605 Section 83.605 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 83.605 Award. Award means an award of financial assistance by the Department of Justice or...

  6. 5 CFR 534.405 - Performance awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Performance awards. 534.405 Section 534... SYSTEMS Pay and Performance Awards Under the Senior Executive Service § 534.405 Performance awards. (a) This section covers the payment of performance awards to career appointees in the Senior...

  7. 10 CFR 607.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Award. 607.605 Section 607.605 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.605 Award. Award means an award of financial assistance by the Department of Energy or...

  8. 42 CFR 66.106 - Awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Awards. 66.106 Section 66.106 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.106 Awards. (a) Within the limits of funds available,...

  9. 42 CFR 66.106 - Awards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Awards. 66.106 Section 66.106 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.106 Awards. (a) Within the limits of funds available,...

  10. 42 CFR 66.106 - Awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Awards. 66.106 Section 66.106 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.106 Awards. (a) Within the limits of funds available,...

  11. 42 CFR 66.106 - Awards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Awards. 66.106 Section 66.106 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.106 Awards. (a) Within the limits of funds available,...

  12. 42 CFR 66.106 - Awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Awards. 66.106 Section 66.106 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.106 Awards. (a) Within the limits of funds available,...

  13. Time course of information representation of macaque AIP neurons in hand manipulation task revealed by information analysis.

    PubMed

    Sakaguchi, Yutaka; Ishida, Fumihiko; Shimizu, Takashi; Murata, Akira

    2010-12-01

    We used mutual information analysis of neuronal activity in the macaque anterior intraparietal area (AIP) to examine information processing during a hand manipulation task. The task was to reach-to-grasp a three-dimensional (3D) object after presentation of a go signal. Mutual information was calculated between the spike counts of individual neurons in 50-ms-wide time bins and six unique shape classifications or 15 one-versus-one classifications of these shapes. The spatiotemporal distribution of mutual information was visualized as a two-dimensional image ("information map") to better observe global profiles of information representation. In addition, a nonnegative matrix factorization technique was applied for extracting its structure. Our major finding was that the time course of mutual information differed significantly according to different classes of task-related neurons. This strongly suggests that different classes of neurons were engaged in different information processing stages in executing the hand manipulation task. On the other hand, our analysis revealed the heterogeneous nature of information representation of AIP neurons. For example, "information latency" (or information onset) varied among individual neurons even in the same neuron class and the same shape classification. Further, some neurons changed "information preference" (i.e., shape classification with the largest amount of information) across different task periods. These suggest that neurons encode different information in the different task periods. Taking the present result together with previous findings, we used a Gantt chart to propose a hypothetical scheme of the dynamic interactions between different types of AIP neurons.

  14. 2015 Gulf Guardian Award Winners

    EPA Pesticide Factsheets

    The Gulf of Mexico Program Partnership developed the Gulf Guardian awards as a way to recognize and honor the businesses, community groups, individuals, and agencies that are taking positive steps to keep the Gulf healthy, beautiful and productive.

  15. Clean Air Excellence Award Recipients

    EPA Pesticide Factsheets

    Recipients are organized by award category within each year: Clean Air Technology, Community Action, Education/Outreach, Regulatory/Policy Innovations, Transportation Efficiency Innovations, Thomas W. Zosel individual, and Gregg Cooke Visionary Program.

  16. Climate Leadership Awards and Conference

    EPA Pesticide Factsheets

    The seventh annual Climate Leadership Awards Dinner will be held during the 2018 Climate Leadership Conference; the event publicly recognize individuals and organizations for their outstanding leadership in reducing greenhouse gas emissions.

  17. Climate Leadership Awards Frequent Questions

    EPA Pesticide Factsheets

    Provides answers to frequently asked questions regarding the Climate Leadership Awards, sponsored by EPA's Center for Corporate Climate Leadership with co-sponsorship from the Center for Climate and Energy Solutions and The Climate Registry.

  18. Nonpoint Source Tribal: Award Projects

    EPA Pesticide Factsheets

    Tribal CWA section 319 funding is awarded via base grants and competitive grants. To learn about current nonpoint source funded work in Indian Country, see the project summary descriptions of recent competitive grant awardees.

  19. Robotic Mining Competition Awards Ceremony

    NASA Image and Video Library

    2017-05-26

    Team Astrobotics from The University of Alabama won the top award, the Joe Kosmo Award for Excellence, and several other awards, during NASA's 8th Annual Robotic Competition award ceremony inside the Apollo-Saturn V Center at the Kennedy Space Center Visitor Complex in Florida. More than 40 student teams from colleges and universities around the U.S. used their uniquely-designed mining robots to dig in a supersized sandbox filled with BP-1, or simulated Martian soil, and participated in other competition requirements, May 22-26, at the visitor complex. The Robotic Mining Competition is a NASA Human Exploration and Operations Mission Directorate project designed to encourage students in science, technology, engineering and math, or STEM fields. The project provides a competitive environment to foster innovative ideas and solutions that could be used on NASA's Journey to Mars.

  20. Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP.

    PubMed

    Pedersen, Linda Margareth; Lien, Guro Flor; Bollerud, Ingunn; Gjerstad, Johannes

    2005-04-11

    Neuronal events leading to development of long-term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying central hyperalgesia. Here, we examine whether induction of LTP in nociceptive dorsal horn neurons at depths of 80-500 microm from the cord surface can be affected by spinal application of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitor AIP. Extracellular recordings from single neurons in intact urethane anesthetized Sprague-Dawley rats were performed, and the neuronal A-fiber and C-fiber responses after sciatic nerve test pulses were defined according to latencies. A clear LTP of the nociceptive transmission following sciatic nerve high-frequency stimulation (HFS) was observed in single neurons in laminae I-IV of the dorsal horn. The increase in the C-fiber response after HFS was blocked in the presence of 2.0 mM AIP (P < 0.05 HFS group versus AIP + HFS group 2 h after conditioning). However, the C-fiber response was not affected by 2.0 mM AIP alone or by vehicle. Thus, our data show that the neuronal process leading to the induction of LTP in the dorsal horn induced by HFS is clearly inhibited by the specific CaMKII inhibitor AIP. It is concluded that CaMKII may be important for the induction of LTP in single nociceptive dorsal horn neurons.

  1. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein.

    PubMed

    Kang, Byoung Heon; Xia, Fang; Pop, Ramona; Dohi, Takehiko; Socolovsky, Merav; Altieri, Dario C

    2011-05-13

    Survivin is a multifunctional protein with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings of its cytoprotective properties are poorly understood. Here we show that homozygous deletion of the aryl hydrocarbon receptor-interacting protein (AIP), a survivin-associated immunophilin, causes embryonic lethality in mice by embryonic day 13.5-14, increased apoptosis of Ter119(-)/CD71(-) early erythropoietic progenitors, and loss of survivin expression in its cytosolic and mitochondrial compartments in vivo. In import assays using recombinant proteins, AIP directly mediated the import of survivin to mitochondria, thus enabling its anti-apoptotic function, whereas a survivin 1-141 mutant that does not bind AIP was not imported to mitochondria and failed to inhibit apoptosis. AIP-directed mitochondrial import of survivin did not affect cell division, was independent of the organelle transmembrane potential, did not require the chaperone Heat Shock Protein 90 (Hsp90), and was inhibited by cytosolic factor(s) present in normal cells. shRNA knockdown of the mitochondrial import receptor Tom20 abolished mitochondrial import of survivin and sensitized tumor cells to apoptosis, whereas silencing of Tom70 had no effect. Therefore, an AIP-Tom20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of survivin.

  2. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.

    PubMed

    Junio, Hiyas A; Todd, Daniel A; Ettefagh, Keivan A; Ehrmann, Brandie M; Kavanaugh, Jeffrey S; Horswill, Alexander R; Cech, Nadja B

    2013-07-01

    Staphylococcus aureus infections acquired in hospitals now cause more deaths per annum in the US than does HIV/AIDS. Perhaps even more alarming is the rise in community associated methicillin-resistant S. aureus (CA-MRSA) infections, which have spread out of hospital settings and are infecting otherwise healthy individuals. The mechanism of enhanced pathogenesis in CA-MRSA remains unclear, but it has been postulated that high activity in the agr quorum-sensing system could be a contributing factor. The purpose of this study was to develop a quantitative method for analysis of autoinducing peptide I (AIP-I), the activating signal for the agr system in S. aureus. An effective method was developed using ultrahigh performance liquid chromatography (UHPLC) coupled to electrospray ionization mass spectrometry with an LTQ Orbitrap mass spectrometer. Relying on the exceptional resolving power and mass accuracy of this instrument configuration, it was possible to quantify AIP-I directly from the complex growth media of S. aureus cultures with a limit of detection (LOD) of 0.25μM and a linear dynamic range of 2.6 to 63μM. The method was then employed to monitor time-dependent production of AIP-I by S. aureus cultures, and it was observed that AIP-I production reached a maximum and leveled off after approximately 16h. Finally, it was determined that virulence of S. aureus was correlated with AIP-I production in some (but not all) strains analyzed.

  3. Does gender bias influence awards given by societies?

    NASA Astrophysics Data System (ADS)

    Holmes, Mary Anne; Asher, Pranoti; Farrington, John; Fine, Rana; Leinen, Margaret S.; LeBoy, Phoebe

    2011-11-01

    AGU is a participant in a U.S. National Science Foundation (NSF)-funded project called Advancing Ways of Awarding Recognition in Disciplinary Societies (AWARDS), which seeks to examine whether gender bias affects selection of recipients of society awards. AGU is interested in learning why there is a higher proportion of female recipients of service and education awards over the past 2 decades. Combined with a lower rate of receipt of research awards, these results suggest that implicit (subconscious) bias in favor of male candidates still influences awardee selection. Six other professional societies (American Chemical Society, American Mathematical Society, American Society of Anesthesiologists, Mathematical Association of America, Society for Neuroscience, and Society for Industrial and Applied Mathematics) are participating in the project. Volunteers from each participant society attended an Association for Women in Science (AWIS)-sponsored workshop in May 2010 to examine data and review literature on best practices for fair selection of society awardees. A draft proposal for implementing these practices will be brought before the AGU Council and the Honors and Recognition Committee at their upcoming meetings.

  4. Thompson receives 1994 Bowen award

    NASA Astrophysics Data System (ADS)

    Green, David H.; Thompson, Alan Bruce

    At the Spring Meeting in Baltimore, May 23, 1994, Alan Bruce Thompson of the Eidgenossiche Technische Hochschule, Zurich, received the 1994 N. L. Bowen Award of the Volcanology, Geochemsitry, and Petrology section, which is given for a single outstanding contribution to volcanology, geochemistry, or petrology made during the preceding 5 years. The award was presented by David H. Green of the Research School of Earth Sciences. The citation and response are given here.

  5. 2 CFR 175.15 - Award term.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Award term. 175.15 Section 175.15 Grants and... GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS AWARD TERM FOR TRAFFICKING IN PERSONS § 175.15 Award term. (a... Federal awarding agency must include the award term in paragraph (b) of this section in— (1) A grant or...

  6. Outstanding student paper award

    NASA Astrophysics Data System (ADS)

    The Planetology Section presented an outstanding student paper award to Julie Ann Rathbun at the AGU 1998 Spring Meeting in Boston, Mass., last May. Julie Ann Rathbun presented a paper titled “Ice Diapirs on Europa and Their Implications."” Julie received her B.S. degree in physics from the State University of New York at Buffalo in May 1994. She has an M.S. in astronomy from Cornell University that she received in July 1997. At present, she is working towards a Ph.D. in astronomy from Cornell under the direction of Steven Squyres. Julie's thesis topic is studying thermal upwellings on Venus and Europa using techniques developed for Coronae formation. She is doing this study in order to understand the subsurface structure of the bodies and how similar processes can differ in icy and rocky bodies. Work already accomplished toward this thesis are Magellan data used to model the formation of Beta Regio and Theia Mons, and Galileo data used to model the formation of small topographic domes to show that a liquid water ocean must have been present at the time of their formation.

  7. Outstanding student paper awards

    NASA Astrophysics Data System (ADS)

    The Hydrology Section presented five outstanding student paper awards at the 1999 Spring Meeting in Boston, Massachusetts, last June.Maneesha Joshi presented a poster titled “Estimation of the Extent and Duration of Melt on the Greenland Ice Sheet using an Edge Detection Technique on Passive Microwave Data.” She received her B.Tech. in civil engineering from the Indian Institute of Technology, Bombay in 1991, and a M.S. in environmental engineering from State University of New York, Buffalo in 1994. Maneesha expects to complete her Ph.D. in civil engineering (remote sensing) in September 1999, under the supervision of Carolyn Merry (Department of Civil and Environmental Engineering & Geodetic Science), Ken Jezek, and John Bolzan (Byrd Polar Research Center) at the Ohio State University, Columbus, Ohio. Her thesis focuses on estimating the extent of melt, melt season, and duration, and absorbed radiation on the Greenland ice sheet from passive microwave and SAR data. Maneesha's other interests include image processing, issues related to global climate change, and photogrammetry.

  8. Degrees in Engineering and Industrial Technology, 1967-68.

    ERIC Educational Resources Information Center

    Engineers Joint Council, New York, NY. Engineering Manpower Commission.

    The number of associate and baccalaureate degrees in engineering and industrial technology awarded by 415 institutions is reported by institution and curriculum. In the academic year 1967-68, 16,920 2-year degrees in engineering technology and 1,560 in industrial technology were awarded. Also 842 bachelor's degrees in engineering technology, and…

  9. Portland, Maine Industrial Pretreatment Program Recognized for Excellence

    EPA Pesticide Factsheets

    The City of Portland Maine's Industrial Pretreatment Program was recently honored with a 2015 Regional Industrial Pretreatment Program Excellence Award by the US Environmental Protection Agency's New England regional office.

  10. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin.

    PubMed

    Ji, Hee Jung; Yeo, Hee Kyoung; Lee, Nam Hee; Hwang, Jung Suk; Koo, Kyung Ah; Cheong, Seon Woo; Park, Joo Hung; Oh, Gap Soo; Yoon, Chun Sik; Youn, Hyun Joo

    2005-02-01

    Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.

  11. 2011 Green Flight Challenge Highlights Video for Awards Ceremony

    NASA Image and Video Library

    2011-10-03

    On Monday, October 3, 2011, NASA's Centennial Challenges program awarded the largest prize in aviation history, created to inspire the development of more fuel-efficient aircraft and spark the start of a new electric airplane industry. Three teams successfully met all requirements and competed for the $1.65 million purse in the CAFE Green Flight Challenge, sponsored by Google, over the skies of Santa Rosa, California.

  12. Best Student Seismology Paper Award

    NASA Astrophysics Data System (ADS)

    Smith, Stewart W.

    Lind S. Gee, a graduate student at the Massachusetts Institute of Technology (MIT), Cambridge, is the first recipient of the AGU Seismology Section's newly established Best Student Paper Award. The award was for her paper on the recovery of upper mantle structure by higher-mode waveform analysis, which was coauthored with A.L. Lerner-Lamand and T.H. Jordan. The calculations that she presented demonstrated that there is a rich potential for earth structure experiments utilizing these techniques. The award is given on the basis of paper content and presentation, and it was clear that her contribution was outstanding on both counts. Lind received her B.A. in Geology from Harvard in 1982 and expects to complete her Ph.D. work at MIT by 1988.

  13. Stennis group receives NESC award

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

  14. Stennis group receives NESC award

    NASA Image and Video Library

    2009-04-14

    The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

  15. 7 CFR 2502.8 - Pre-award, award, and post-award procedures and administration of grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Pre-award, award, and post-award procedures and administration of grants. 2502.8 Section 2502.8 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE AGRICULTURAL CAREER AND EMPLOYMENT...

  16. Stanley receives 2010 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Weiss, Benjamin P.

    2011-06-01

    Sabine Stanley received the William Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  17. Kirschvink receives 2011 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Weiss, Benjamin P.

    2012-04-01

    Joseph Kirschvink received the William Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  18. Kirschvink receives 2011 William Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Kirschvink, Joseph L.

    2012-04-01

    Joseph Kirschvink received the William Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  19. Lagroix Receives 2008 William Gilbert Award

    NASA Astrophysics Data System (ADS)

    Moskowitz, Bruce M.; Banerjee, Subir K.; Lagroix, France

    2009-04-01

    France Lagroix received the William Gilbert Award at the 2008 AGU Fall Meeting Honors Ceremony, held 17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  20. Dennis Kent Receives 2009 William Gilbert Award

    NASA Astrophysics Data System (ADS)

    Tauxe, Lisa; Kent, Dennis

    2010-06-01

    Dennis Kent received the William Gilbert Award at the 2009 AGU Fall Meeting, held 14-18 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  1. Stanley receives 2010 William Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Stanley, Sabine

    2011-06-01

    Sabine Stanley received the William Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  2. The Outstanding Investigator Award (R35)

    Cancer.gov

    NCI established the Outstanding Investigator Award (R35) in 2014, for principal investigators who have achieved significant research accomplishments. This video features one of the first group of 62 researchers to receive the award.

  3. Sylvanus Albert Reed Award: Eastman N. Jacobs

    NASA Technical Reports Server (NTRS)

    1937-01-01

    Sylvanus Albert Reed Award - Eastman N. Jacobs: In 1937, Eastman N. Jacobs, one of Langley's most adventurous researchers, received the Sylvanus Albert Reed Award for his contributions to the aerodynamic improvement of airfoils.

  4. Clean Cities Coalition and Coordinator Awards 2003

    SciTech Connect

    Not Available

    2003-06-01

    This fact sheet recognizes the 2003 Clean Cities Coalition and Coordinator awards winners and their outstanding efforts to promote alternative fuels and alternative fuel vehicles. The recipients will receive their awards at the Clean Cities Conference in Palm Springs, CA.

  5. The Outstanding Investigator Award (R35)

    Cancer.gov

    NCI established the Outstanding Investigator Award (R35) in 2015, for principal investigators who have achieved significant research accomplishments. This video features one of the first group of 62 researchers to receive the award.

  6. Professionalism and Awards in Television News Photography.

    ERIC Educational Resources Information Center

    Smith, Conrad; Hubbard, Tom

    1987-01-01

    Tests the hypothesis that photojournalists with high professionalism scores are more likely to win news photography awards. Suggests that television news photography awards recognize skills gained through experience rather than specific professional values. (MM)

  7. 7 CFR 900.116 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... award, may use his own technical knowledge in addition to the evidence submitted by the parties. (3) The award shall state the period during which it shall be in effect, said period to be not less than...

  8. 46 CFR Sec. 6 - Awarding of work.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 6 Awarding... Repair Summary. (c) When an award is made, a job order in the form attached to the NSA-LUMPSUMREP...

  9. 46 CFR Sec. 6 - Awarding of work.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 6 Awarding... Repair Summary. (c) When an award is made, a job order in the form attached to the NSA-LUMPSUMREP...

  10. 46 CFR Sec. 6 - Awarding of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 6 Awarding... Repair Summary. (c) When an award is made, a job order in the form attached to the NSA-LUMPSUMREP...

  11. 24 CFR 585.302 - Award limits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Award limits. 585.302 Section 585... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Implementation Grants § 585.302 Award limits... than the specified limit. ...

  12. 24 CFR 585.302 - Award limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Award limits. 585.302 Section 585... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Implementation Grants § 585.302 Award limits... than the specified limit. ...

  13. Vermont Official Receives Prestigious EPA Environmental Award

    EPA Pesticide Factsheets

    At a ceremony today in Boston, Justin Johnson, the newly appointed secretary of the Vermont Agency of Administration, was today awarded the Ira Leighton Award, recognizing his 10 years of service and leadership on environmental issues in Vermont.

  14. 2 CFR 175.15 - Award term.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Award term. 175.15 Section 175.15 Grants and... section in— (1) A grant or cooperative agreement to a private entity, as defined in § 175.25(d); and (2) A... performance of the award or subawards under the award. 2. We as the Federal awarding agency may unilaterally...

  15. 2 CFR 175.15 - Award term.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Award term. 175.15 Section 175.15 Grants and... section in— (1) A grant or cooperative agreement to a private entity, as defined in § 175.25(d); and (2) A... performance of the award or subawards under the award. 2. We as the Federal awarding agency may unilaterally...

  16. 2 CFR 170.220 - Award term.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Award term. 170.220 Section 170.220 Grants... COMPENSATION INFORMATION Policy § 170.220 Award term. (a) To accomplish the purposes described in § 170.100, an agency must include the award term in appendix A to this part in each award to a non-Federal entity under...

  17. 2 CFR 170.220 - Award term.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term. 170.220 Section 170.220 Grants... COMPENSATION INFORMATION Policy § 170.220 Award term. (a) To accomplish the purposes described in § 170.100, an agency must include the award term in Appendix A to this part in each award to a non-Federal entity under...

  18. Cost Reduction Incentive Awards. 1981 Winners.

    ERIC Educational Resources Information Center

    National Association of College and University Business Officers, Washington, DC.

    Brief descriptions of 47 college programs recognized for awards in the National Association of College and University Officers/U. S. Steel Foundation Cost Reduction Incentive Awards Program are given. They include awards for: shower stall repair; chemical waste exchange; vibrating alarms for hearing-imparied; self-funding insurance consortium;…

  19. 45 CFR 148.320 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Grant awards. 148.320 Section 148.320 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.320 Grant awards. (a) Notification and award letter. (1) Each State applicant will be notified in...

  20. 7 CFR 1709.217 - Grant award.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Grant award. 1709.217 Section 1709.217 Agriculture... ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.217 Grant award. (a... selected for a grant award. (b) Letter of conditions. The Agency will notify a selected applicant in...

  1. 7 CFR 3400.6 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3400.6 Section 3400.6 Agriculture... RESEARCH GRANTS PROGRAM General § 3400.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible...

  2. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3401.8 Section 3401.8 Agriculture... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible...

  3. 7 CFR 3400.6 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3400.6 Section 3400.6 Agriculture... RESEARCH GRANTS PROGRAM General § 3400.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible...

  4. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3401.8 Section 3401.8 Agriculture... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible...

  5. 45 CFR 148.320 - Grant awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Grant awards. 148.320 Section 148.320 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.320 Grant awards. (a) Notification and award letter. (1) Each State applicant will be notified in...

  6. Standout Performances: The NACE Annual Awards.

    ERIC Educational Resources Information Center

    Journal of Career Planning & Employment, 1999

    1999-01-01

    Profiles NACE's 1999 Employer of the Year, Academy of Fellows inductees, Kauffman Award honoree, and Awards of Excellence recipients. Also profiles Awards of Excellence recipients for the following categories: Publications for Students, Adiovisual Programs, Educational Programming, and Technical Innovations. (Author/JDM)

  7. 36 CFR 1212.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1212.605 Award. Award...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  8. 40 CFR 36.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 36.605 Award. Award means an award of...: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2... include: (1) Technical assistance that provides services instead of money. (2) Loans. (3) Loan...

  9. 36 CFR 1212.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1212.605 Award. Award...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  10. 36 CFR 1212.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1212.605 Award. Award...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  11. 36 CFR 1212.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1212.605 Award. Award...) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  12. 45 CFR 148.320 - Grant awards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Grant awards. 148.320 Section 148.320 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.320 Grant awards. (a) Notification and award letter. (1) Each State applicant will be notified...

  13. 7 CFR 1709.217 - Grant award.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Grant award. 1709.217 Section 1709.217 Agriculture... ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.217 Grant award. (a... selected for a grant award. (b) Letter of conditions. The Agency will notify a selected applicant...

  14. 42 CFR 57.2206 - Grant award.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Grant award. 57.2206 Section 57.2206 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING... Grants § 57.2206 Grant award. The Secretary may award scholarship grants to individuals who have...

  15. 5 CFR 534.405 - Performance awards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Performance awards. 534.405 Section 534.405 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER OTHER SYSTEMS Pay and Performance Awards Under the Senior Executive Service § 534.405 Performance awards. (a...

  16. 41 CFR 105-74.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Award. 105-74.605 Section 105-74.605 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.605 Award. Award...

  17. Sington receives the 1999 Walter Sullivan award

    NASA Astrophysics Data System (ADS)

    McKenzie, Dan P.; Sington, David

    David Sington was awarded the 1999 Walter Sullivan Award for Excellence in Science Journalism at the AGU Spring Meeting Honors Ceremony, which was held on June 2, 1999, in Boston, Massachusetts. The award recognizes a single article or a radio/television report that makes geophysical material accessible and interesting to the general public.

  18. 22 CFR 312.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.605 Award. Award means an award of financial assistance by the Peace Corps or other Federal agency...)(2) of this section, this paragraph is not applicable for the Peace Corps. ...

  19. 22 CFR 312.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.605 Award. Award means an award of financial assistance by the Peace Corps or other Federal agency...) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct appropriations....

  20. 22 CFR 312.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.605 Award. Award means an award of financial assistance by the Peace Corps or other Federal agency...) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct appropriations....

  1. 22 CFR 312.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.605 Award. Award means an award of financial assistance by the Peace Corps or other Federal agency...) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct appropriations....

  2. 22 CFR 312.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.605 Award. Award means an award of financial assistance by the Peace Corps or other Federal agency...) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct appropriations....

  3. Rebecca Knuth: LJ Teaching Award 2009

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    This article profiles Rebecca Knuth, winner of the LJ Teaching Award for 2009. The way she plans a class she's teaching illustrates why she was nominated by her students and won the award. The award, which comes with a $5000 honorarium and a celebration at the American Library Association (ALA) Midwinter Meeting, is sponsored by ProQuest. For…

  4. 42 CFR 52.6 - Grant awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Grant awards. 52.6 Section 52.6 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR RESEARCH PROJECTS § 52.6 Grant awards. (a) Within the limits of funds available for that purpose, the Secretary will award...

  5. 42 CFR 57.2206 - Grant award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Grant award. 57.2206 Section 57.2206 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING... Grants § 57.2206 Grant award. The Secretary may award scholarship grants to individuals who have...

  6. 13 CFR 308.2 - Performance awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Performance awards. 308.2 Section... PERFORMANCE INCENTIVES § 308.2 Performance awards. (a) A Recipient of Investment Assistance under parts 305 or 307 of this chapter may receive a performance award in connection with an Investment made on or...

  7. 43 CFR 4.1295 - Awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Applicable to Surface Coal Mining Hearings and Appeals Petitions for Award of Costs and Expenses Under Section 525(e) of the Act § 4.1295 Awards. An award under these sections may include— (a) All costs and... and/or participation in a proceeding under the Act; and (b) All costs and expenses,...

  8. 43 CFR 4.1295 - Awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Applicable to Surface Coal Mining Hearings and Appeals Petitions for Award of Costs and Expenses Under Section 525(e) of the Act § 4.1295 Awards. An award under these sections may include— (a) All costs and... and/or participation in a proceeding under the Act; and (b) All costs and expenses,...

  9. 45 CFR 630.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.605 Award. Award means an award of financial assistance by the National Science Foundation or other Federal agency directly to a recipient. (a...

  10. 45 CFR 630.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.605 Award. Award means an award of financial assistance by the National Science Foundation or other Federal agency directly to a recipient. (a...

  11. Rebecca Knuth: LJ Teaching Award 2009

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    This article profiles Rebecca Knuth, winner of the LJ Teaching Award for 2009. The way she plans a class she's teaching illustrates why she was nominated by her students and won the award. The award, which comes with a $5000 honorarium and a celebration at the American Library Association (ALA) Midwinter Meeting, is sponsored by ProQuest. For…

  12. Cost Reduction Incentive Awards. 1981 Winners.

    ERIC Educational Resources Information Center

    National Association of College and University Business Officers, Washington, DC.

    Brief descriptions of 47 college programs recognized for awards in the National Association of College and University Officers/U. S. Steel Foundation Cost Reduction Incentive Awards Program are given. They include awards for: shower stall repair; chemical waste exchange; vibrating alarms for hearing-imparied; self-funding insurance consortium;…

  13. Degrees and Certificates Awarded, 2001-2002.

    ERIC Educational Resources Information Center

    Coperthwaite, Corby A.; Jones, Dennis

    This document reports on degrees and certificates awarded by the Connecticut community colleges during the 2001-02 academic year, using a set of eight categories. The colleges awarded 3,977 degrees and certificates in 2001-02. This represents a 1.3% increase over the previous year, and a 7.2% decrease since 1998. The colleges awarded 735…

  14. 2 CFR 175.15 - Award term.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term. 175.15 Section 175.15 Grants and... GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERM FOR TRAFFICKING IN PERSONS § 175.15 Award term. (a) To implement the trafficking in persons requirement in section 106(g) of the TVPA, as amended...

  15. IRA Award-Winning Research.

    ERIC Educational Resources Information Center

    Seifert, Mary

    1984-01-01

    Summarizes award-winning research produced by Andrew M.Hess, Sirkka-Liisa Rauramo, Richard L. Allington, Donna E. Alvermann and David A. Hayes, Lesley M. Morrow and Carol S. Weinstein, Taffy E. Raphael and Bonnie B. Armbruster, Nancy Nelson Spivey, and Courtney B. Cazden. (FL)

  16. 1997 Australian Rural Education Award.

    ERIC Educational Resources Information Center

    Education in Rural Australia, 1997

    1997-01-01

    Nominees for the 1997 Australia Rural Education Award included a program that allowed rural students to follow a young man sailing around the world; a music, dance, and drama competition for rural students; a music camp; a bandicoot conservation project; an agricultural education program; and student documentation of the history of a local rural…

  17. Vergano Receives David Perlman Award

    NASA Astrophysics Data System (ADS)

    Kelly, Sue

    2006-08-01

    Dan Vergano received the Perlman Award at the Joint Assembly Honors Ceremony, whichwas held on 25 May 2006 in Baltimore, Md. Vergano was honored for `The Debate's over:Globe is warming,' which describes the linkages between the science of climate change andthe complexity of technical and economic decisions facing its mitigation.

  18. Carter G. Woodson Book Awards.

    ERIC Educational Resources Information Center

    Social Education, 2000

    2000-01-01

    Presents the recipients of the 1999 Carter G. Woodson book awards that honor books focusing on ethnic minorities and race relations that are appropriate for elementary and secondary levels. Includes books that cover topics such as life for Japanese Americans in internment camps and lives of 12 black women. (CMK)

  19. Campus Technology Innovators Awards 2009

    ERIC Educational Resources Information Center

    Grush, Mary; Villano, Matt

    2009-01-01

    The annual Campus Technology Innovators awards recognize higher education institutions that take true initiative--even out-and-out risk--to better serve the campus community via technology. These top-notch university administrators, faculty, and staff demonstrate something more than a "job well done"; their vision and leadership have…

  20. Student Merit Awards: High School.

    ERIC Educational Resources Information Center

    Sachs, Leroy, Ed.

    The Student Merit Award Program was designed to motivate, stimulate and reward students for their study and achievement outside the mathematics classroom by providing enrichment material on a variety of mathematical topics. In general, these topics are either not found in the standard curriculum or represent a more in-depth study of standard…

  1. Five Libraries Capture Architectural Awards.

    ERIC Educational Resources Information Center

    American Libraries, 1985

    1985-01-01

    Presents detailed look at University of Michigan Law, Folger Shakespeare, Vail Public, San Francisco University High School, and New York University Graduate School of Business Libraries, winners of 11th Library Buildings Award Program which included two renovations, two additions, and one new facility. Other notable library design projects are…

  2. Impact on Learning Award Winners.

    ERIC Educational Resources Information Center

    School Planning & Management, 2000

    2000-01-01

    Presents awardees of the School Planning & Management magazine's third annual "Impact on Learning Award" given to architectural firms whose K-12 school facilities have solved real-world problems through design, engineering, and technology solutions. Each selection presents the design challenge faced and its solution along with project details. (GR)

  3. NASEN Academic Book Award 1999.

    ERIC Educational Resources Information Center

    Galloway, David; Fowlie, Anne; Pearson, Sue; Williams, Anna

    2000-01-01

    This article discusses the winners of the British National Association for Special Education Needs book award for 1999: "Literature for All" by Nicola Grove and "Promoting Inclusive Practice" edited by Christina Tilstone and others. The winners are chosen for their ability to inform and inspire special education professionals.…

  4. Campus Technology Innovators Awards 2009

    ERIC Educational Resources Information Center

    Grush, Mary; Villano, Matt

    2009-01-01

    The annual Campus Technology Innovators awards recognize higher education institutions that take true initiative--even out-and-out risk--to better serve the campus community via technology. These top-notch university administrators, faculty, and staff demonstrate something more than a "job well done"; their vision and leadership have…

  5. IRA Award-Winning Research.

    ERIC Educational Resources Information Center

    Seifert, Mary

    1984-01-01

    Summarizes award-winning research produced by Andrew M.Hess, Sirkka-Liisa Rauramo, Richard L. Allington, Donna E. Alvermann and David A. Hayes, Lesley M. Morrow and Carol S. Weinstein, Taffy E. Raphael and Bonnie B. Armbruster, Nancy Nelson Spivey, and Courtney B. Cazden. (FL)

  6. Student Merit Awards: Middle School.

    ERIC Educational Resources Information Center

    Sachs, Leroy, Ed.

    The Student Merit Award Program was designed to motivate, stimulate and reward students for their study and achievement outside the mathematics classroom by providing enrichment material on a variety of mathematical topics. In general, these topics are either not found in the standard middle school curriculum or represent a more in-depth study of…

  7. Impact on Learning Award, 2002.

    ERIC Educational Resources Information Center

    School Planning & Management, 2002

    2002-01-01

    Describes winners of the title award, K-12 school facilities that have solved real-world problems through design, engineering, and technology solutions. Winners were named in the following categories: accessibility, accommodating technology, energy efficient/hi-performance buildings, furniture and equipment for learning, historic preservation,…

  8. Student Merit Awards: High School.

    ERIC Educational Resources Information Center

    Sachs, Leroy, Ed.

    The Student Merit Award Program was designed to motivate, stimulate and reward students for their study and achievement outside the mathematics classroom by providing enrichment material on a variety of mathematical topics. In general, these topics are either not found in the standard curriculum or represent a more in-depth study of standard…

  9. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.

    PubMed

    Salvatori, Roberto; Radian, Serban; Diekmann, Yoan; Iacovazzo, Donato; David, Alessia; Gabrovska, Plamena; Grassi, Giorgia; Bussell, Anna-Marie; Stals, Karen; Weber, Astrid; Quinton, Richard; Crowne, Elizabeth C; Corazzini, Valentina; Metherell, Lou; Kearney, Tara; Du Plessis, Daniel; Sinha, Ajay Kumar; Baborie, Atik; Lecoq, Anne-Lise; Chanson, Philippe; Ansorge, Olaf; Ellard, Sian; Trainer, Peter J; Balding, David; Thomas, Mark G; Korbonits, Márta

    2017-09-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events. Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8.3 Mbp) haplotypes; coalescent-based approximate Bayesian estimation of the time to most recent common ancestor (tMRCA) of the derived allele; forward population simulations to estimate current number of allele carriers; proposal of mutation mechanism; protein structure predictions; co-immunoprecipitation and cycloheximide chase experiments. Nine European-origin, unrelated c.805_825dup-positive pedigrees (four familial, five sporadic from the UK, USA and France) included 16 affected (nine gigantism/four acromegaly/two non-functioning pituitary adenoma patients and one prospectively diagnosed acromegaly patient) and nine unaffected carriers. All pedigrees shared a 2.79 Mbp haploblock around AIP with additional haploblocks privately shared between subsets of the pedigrees, indicating the existence of an evolutionarily recent common ancestor, the 'English founder', with an estimated median tMRCA of 47 generations (corresponding to 1175 years) with a confidence interval (9-113 generations, equivalent to 225-2825 years). The mutation occurred in a small tandem repeat region predisposed to slipped strand mispairing. The resulting seven amino-acid duplication disrupts interaction with HSP90 and leads to a marked reduction in protein stability. The c.805_825dup allele, originating from a common ancestor, associates with a severe clinical phenotype and a high frequency of gigantism. The mutation is likely to be the result of slipped strand mispairing and affects protein-protein interactions and AIP protein stability. © 2017 The authors.

  10. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line

    PubMed Central

    Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip. PMID:27706259

  11. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.

    PubMed

    Fukuda, Takashi; Tanaka, Tomoko; Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip.

  12. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism

    PubMed Central

    Salvatori, Roberto; Radian, Serban; Diekmann, Yoan; Iacovazzo, Donato; David, Alessia; Gabrovska, Plamena; Grassi, Giorgia; Bussell, Anna-Marie; Stals, Karen; Weber, Astrid; Quinton, Richard; Crowne, Elizabeth C; Corazzini, Valentina; Metherell, Lou; Kearney, Tara; Du Plessis, Daniel; Sinha, Ajay Kumar; Baborie, Atik; Lecoq, Anne-Lise; Chanson, Philippe; Ansorge, Olaf; Ellard, Sian; Trainer, Peter J; Balding, David; Thomas, Mark G

    2017-01-01

    Objective Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events. Design and methods Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8.3 Mbp) haplotypes; coalescent-based approximate Bayesian estimation of the time to most recent common ancestor (tMRCA) of the derived allele; forward population simulations to estimate current number of allele carriers; proposal of mutation mechanism; protein structure predictions; co-immunoprecipitation and cycloheximide chase experiments. Results Nine European-origin, unrelated c.805_825dup-positive pedigrees (four familial, five sporadic from the UK, USA and France) included 16 affected (nine gigantism/four acromegaly/two non-functioning pituitary adenoma patients and one prospectively diagnosed acromegaly patient) and nine unaffected carriers. All pedigrees shared a 2.79 Mbp haploblock around AIP with additional haploblocks privately shared between subsets of the pedigrees, indicating the existence of an evolutionarily recent common ancestor, the ‘English founder’, with an estimated median tMRCA of 47 generations (corresponding to 1175 years) with a confidence interval (9–113 generations, equivalent to 225–2825 years). The mutation occurred in a small tandem repeat region predisposed to slipped strand mispairing. The resulting seven amino-acid duplication disrupts interaction with HSP90 and leads to a marked reduction in protein stability. Conclusions The c.805_825dup allele, originating from a common ancestor, associates with a severe clinical phenotype and a high frequency of gigantism. The mutation is likely to be the result of slipped strand mispairing and affects protein–protein interactions and AIP protein stability. PMID:28634279

  13. Award for Distinguished Scientific Contributions: Dedre Gentner.

    PubMed

    2016-11-01

    The American Psychological Association (APA) Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. One of the 2016 award winners is Dedre Gentner, who received this award for her "achievements in research and theory in cognitive psychology and cognitive development, especially for developing the structure-mapping theory of analogy and similarity." Her award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  14. Dr. Solco Tromp and the Tromp Award

    NASA Astrophysics Data System (ADS)

    Greene, J. Scott; Rietveld, Wop J.

    2017-09-01

    The Tromp Award is the highest honor awarded by the International Society of Biometeorology (ISB). The award acknowledges outstanding research in biometeorology by a scientist under the age of 35 and was established in conjunction with the Tromp Foundation and the ISB. In honor of the 60th anniversary of the ISB, this article will provide a brief summary of the life of Dr. Solco Tromp and of the six awardees of the Tromp Award since the inaugural issuance of the award in 1999. The Tromp Award was established in part to recognize and support the efforts of young biometeorological professionals. As the brief summary of the awardees and a few of their selected subsequent publications have shown, the ISB and the Tromp Award has proven effective at identifying and supporting promising young scientists.

  15. Dr. Solco Tromp and the Tromp Award

    NASA Astrophysics Data System (ADS)

    Greene, J. Scott; Rietveld, Wop J.

    2017-06-01

    The Tromp Award is the highest honor awarded by the International Society of Biometeorology (ISB). The award acknowledges outstanding research in biometeorology by a scientist under the age of 35 and was established in conjunction with the Tromp Foundation and the ISB. In honor of the 60th anniversary of the ISB, this article will provide a brief summary of the life of Dr. Solco Tromp and of the six awardees of the Tromp Award since the inaugural issuance of the award in 1999. The Tromp Award was established in part to recognize and support the efforts of young biometeorological professionals. As the brief summary of the awardees and a few of their selected subsequent publications have shown, the ISB and the Tromp Award has proven effective at identifying and supporting promising young scientists.

  16. Nuclear Fusion Award 2009 speech Nuclear Fusion Award 2009 speech

    NASA Astrophysics Data System (ADS)

    Sabbagh, Steven Anthony

    2011-01-01

    This is an exceptional moment in my career, and so I want to thank all of my teachers, colleagues and mentors who have made this possible. From my co-authors and myself, many thanks to the International Atomic Energy Agency, IOP Publishing, the Nuclear Fusion journal team, and the selection committee for the great honor of receiving this award. Also gratitude to Kikuchi-sensei, not only for the inventive and visionary creation of this award, but also for being a key mentor dating back to his efforts in producing high neutron output in JT-60U. It was also a great honor to receive the award directly from IAEA Deputy Director General Burkart during the 23rd IAEA Fusion Energy Conference in Daejeon. Receiving the award at this venue is particularly exciting as Daejeon is home to the new, next-generation KSTAR tokamak device that will lead key magnetic fusion research areas going forward. I would also like to thank the mayor of Daejeon, Dr Yum Hong-Chul, and all of the meeting organizers for giving us all a truly spectacular and singular welcoming event during which the award was presented. The research leading to the award would not have been possible without the support of the US Department of Energy, and I thank the Department for the continued funding of this research. Special mention must be made to a valuable co-author who is no longer with us, Professor A. Bondeson, who was a significant pioneer in resistive wall mode (RWM) research. I would like to thank my wife, Mary, for her infinite patience and encouragement. Finally, I would like to personally thank all of you that have approached and congratulated me directly. There are no units to measure how important your words have been in this regard. When notified that our paper had been shortlisted for the 2009 Nuclear Fusion Award, my co-authors responded echoing how I felt—honored to be included in such a fine collection of research by colleagues. It was unfathomable—would this paper follow the brilliant work

  17. Small Business Innovation Research: Abstracts of Phase 1 awards, 1994

    SciTech Connect

    Not Available

    1994-12-31

    The Small Business Innovation Research (SBIR) program enables DOE to obtain effective, innovative solutions to important problems through the private sector, which has a commercial incentive to pursue the resulting technology and bring it to the marketplace. The growing number of awardees, many of them started in business in response to SBIR solicitations, is becoming a significant resource for the solution of high risk, high technology problems for the Department. As detailed here, this publication describes the technical efforts for SBIR Phase 1 awards in 1994. It is intended for the educated layman, and may be of particular interest to potential investors who wish to get in on the ground floor of exciting opportunities. Contained in this booklet are abstracts of the Phase 1 awards made in FY 1994 under the DOE SBIR program. The 212 Phase 1 projects described here were selected in a highly competitive process from a total of 2,276 grant applications received in response to the 1994 DOE annual SBIR Solicitation. The selections for awards were made on scientific and technical merit, as judged against the specific criteria listed in the Solicitation. Conclusions were reached on the basis of detailed reports returned by reviewers drawn from DOE laboratories, universities, private industry, and government. (Any discrepancies noted in prior DOE releases naming the firms selected for awards are due either to the firm changing its name after the award selection or to the firm not proceeding to a signed grant.) It is expected that between one-third and one-half of the Phase 1 projects will be continued into Phase 2. The work described in the abstracts is novel, high-risk research, but the benefits will also be potentially high if the objectives are met. Brief comments on the potential applications are given after each abstract. Individuals and organizations with an interest in the research described are encouraged to contact the appropriate small business directly.

  18. Robotic Mining Competition Awards Ceremony

    NASA Image and Video Library

    2017-05-26

    Inside the Apollo-Saturn V Center at the Kennedy Space Center Visitor Complex in Florida, team members from the University of North Carolina at Charlotte receive third-place in the Caterpillar Autonomy Award during the award ceremony for NASA's 8th Annual Robotic Mining Competition. More than 40 student teams from colleges and universities around the U.S. used their uniquely-designed mining robots to dig in a supersized sandbox filled with BP-1, or simulated Martian soil, and participated in other competition requirements, May 22-26, at the visitor complex. The Robotic Mining Competition is a NASA Human Exploration and Operations Mission Directorate project designed to encourage students in science, technology, engineering and math, or STEM fields. The project provides a competitive environment to foster innovative ideas and solutions that could be used on NASA's Journey to Mars.

  19. Robotic Mining Competition Awards Ceremony

    NASA Image and Video Library

    2017-05-26

    Inside the Apollo-Saturn V Center at the Kennedy Space Center Visitor Complex in Florida, Lisa May, with Murphian Systems, presents the Judges Innovation Award during the award ceremony for NASA's 8th Annual Robotic Mining Competition. More than 40 student teams from colleges and universities around the U.S. used their uniquely-designed mining robots to dig in a supersized sandbox filled with BP-1, or simulated Martian soil, and participated in other competition requirements, May 22-26, at the visitor complex. The Robotic Mining Competition is a NASA Human Exploration and Operations Mission Directorate project designed to encourage students in science, technology, engineering and math, or STEM fields. The project provides a competitive environment to foster innovative ideas and solutions that could be used on NASA's Journey to Mars.

  20. Contract Award on Initial Proposals

    DTIC Science & Technology

    1988-09-30

    technical deficiencies in a proposal, it is proper to hold only cost discussions. This was recently illustrated in Control Data Corp.191 In that case ...illustrated by Technical Micronics Control , Inc.,205 a case where the agency went too far. The solicitation for operation and maintenance of a government... controlled by statute. This chapter will explore those statutes and their antecedents. The basic rules for awarding contracts without discussions

  1. 28 CFR 523.14 - Industrial good time.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Industrial good time. 523.14 Section 523..., AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.14 Industrial good time. Extra good time... Industries is not awarded industrial good time until actually employed....

  2. 28 CFR 523.14 - Industrial good time.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Industrial good time. 523.14 Section 523..., AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.14 Industrial good time. Extra good time... Industries is not awarded industrial good time until actually employed....

  3. 28 CFR 523.14 - Industrial good time.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Industrial good time. 523.14 Section 523..., AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.14 Industrial good time. Extra good time... Industries is not awarded industrial good time until actually employed....

  4. 28 CFR 523.14 - Industrial good time.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Industrial good time. 523.14 Section 523..., AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.14 Industrial good time. Extra good time... Industries is not awarded industrial good time until actually employed....

  5. 28 CFR 523.14 - Industrial good time.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Industrial good time. 523.14 Section 523..., AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.14 Industrial good time. Extra good time... Industries is not awarded industrial good time until actually employed....

  6. EDITORIAL: The Nuclear Fusion Award The Nuclear Fusion Award

    NASA Astrophysics Data System (ADS)

    Kikuchi, M.

    2011-01-01

    The Nuclear Fusion Award ceremony for 2009 and 2010 award winners was held during the 23rd IAEA Fusion Energy Conference in Daejeon. This time, both 2009 and 2010 award winners were celebrated by the IAEA and the participants of the 23rd IAEA Fusion Energy Conference. The Nuclear Fusion Award is a paper prize to acknowledge the best distinguished paper among the published papers in a particular volume of the Nuclear Fusion journal. Among the top-cited and highly-recommended papers chosen by the Editorial Board, excluding overview and review papers, and by analyzing self-citation and non-self-citation with an emphasis on non-self-citation, the Editorial Board confidentially selects ten distinguished papers as nominees for the Nuclear Fusion Award. Certificates are given to the leading authors of the Nuclear Fusion Award nominees. The final winner is selected among the ten nominees by the Nuclear Fusion Editorial Board voting confidentially. 2009 Nuclear Fusion Award nominees For the 2009 award, the papers published in the 2006 volume were assessed and the following papers were nominated, most of which are magnetic confinement experiments, theory and modeling, while one addresses inertial confinement. Sabbagh S.A. et al 2006 Resistive wall stabilized operation in rotating high beta NSTX plasmas Nucl. Fusion 46 635-44 La Haye R.J. et al 2006 Cross-machine benchmarking for ITER of neoclassical tearing mode stabilization by electron cyclotron current drive Nucl. Fusion 46 451-61 Honrubia J.J. et al 2006 Three-dimensional fast electron transport for ignition-scale inertial fusion capsules Nucl. Fusion 46 L25-8 Ido T. et al 2006 Observation of the interaction between the geodesic acoustic mode and ambient fluctuation in the JFT-2M tokamak Nucl. Fusion 46 512-20 Plyusnin V.V. et al 2006 Study of runaway electron generation during major disruptions in JET Nucl. Fusion 46 277-84 Pitts R.A. et al 2006 Far SOL ELM ion energies in JET Nucl. Fusion 46 82-98 Berk H.L. et al 2006

  7. 10 years of Elsevier/JQSRT awards

    NASA Astrophysics Data System (ADS)

    Stoop, José; Bernath, Peter F.; Mengüç, M. Pinar; Mishchenko, Michael I.; Rothman, Laurence S.

    2017-10-01

    The Elsevier award program administered by the Editorial Board of the Journal of Quantitative Spectroscopy and Radiative Transfer (JQSRT) was conceived in June of 2006 at the 9th Electromagnetic and Light Scattering Conference in St. Petersburg, Russia. Initially the program included three annual Elsevier/JQSRT awards for exceptional early-career scientists working in the main research fields covered by JQSRT: quantitative spectroscopy, radiative transfer, and electromagnetic scattering. In June of 2010 at the 12th Electromagnetic and Light Scattering Conference in Helsinki, Finland, it was decided to expand the award program to include three biennial Elsevier awards intended to celebrate fundamental life-time achievements of internationally recognized leaders in the same research fields. Finally, in 2013 the Elsevier award program was augmented to include a fourth annual early-career award in the category of atmospheric radiation and remote sensing.

  8. Size of Undergraduate Physics and Astronomy Programs: Data from the AIP Enrollments and Degrees and Academic Workforce Surveys. Focus On

    ERIC Educational Resources Information Center

    Mulvey, Patrick; Tyler, John; Nicholson, Starr; Ivie, Rachel

    2017-01-01

    This report provides data on the size of degree-granting physics and astronomy departments by examining the number of bachelor's degrees awarded and the number of full-time equivalent (FTE) faculty members employed. The benchmarking data in this report is intended to allow physics and astronomy departments to see how they fit in the national…

  9. U.S. EPA SBIR Award Recipient Receives 2015 Tibbetts Award

    EPA Pesticide Factsheets

    Precision Combustion Inc. (PCI), an EPA SBIR award recipient , received the 2015 Tibbetts Award for developing and manufacturing advanced performance catalytic reactors and systems for energy, defense and environmental applications.

  10. EPA awards Loudoun Valley High School teacher with Presidential Innovation Award

    EPA Pesticide Factsheets

    PHILADELPHIA (August 17, 2015) --The U.S. Environmental Protection Agency has awarded Liam McGranaghan of Loudoun Valley High School in Purcellville, Va. with the Presidential Innovation Award for Environmental Educators (PIAEE).

  11. Climate Leadership Award for Excellence in GHG Management (Goal Achievement Award)

    EPA Pesticide Factsheets

    Apply to the Climate Leadership Award for Excellence in GHG Management (Goal Achievement Award), which publicly recognizes organizations that achieve publicly-set aggressive greenhouse gas emissions reduction goals.

  12. Eastern Band of Cherokee Indians Awarded 2015 EPA Region 4 Rain Catcher Award

    EPA Pesticide Factsheets

    ATLANTA - The Environmental Protection Agency (EPA) recognized the Eastern Band of Cherokee Indians with the regional 2015 EPA Rain Catcher Award in the Tribal Category for the Native Plant Facility project in western North Carolina. The award was g

  13. NICBR Announces First Collaboration Project Awards | Poster

    Cancer.gov

    Courtesy of the NICBR Public Affairs/Community Relations Subcommittee The National Interagency Confederation for Biological Research (NICBR) announced the 2012 NICBR Collaboration Project Award (CPA) Program winners in December. The award, the first of its kind for NICBR, was adapted from the National Cancer Institute’s (NCI’s) Young Investigator Award Program. This year, the CPA was bestowed to three research projects pertaining to collaborations between NICBR agencies.

  14. 45 CFR 12.5 - Awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Awards. 12.5 Section 12.5 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.5 Awards. Where there is more than one applicant for the same property, it will be awarded to the applicant...

  15. NICBR Announces First Collaboration Project Awards | Poster

    Cancer.gov

    Courtesy of the NICBR Public Affairs/Community Relations Subcommittee The National Interagency Confederation for Biological Research (NICBR) announced the 2012 NICBR Collaboration Project Award (CPA) Program winners in December. The award, the first of its kind for NICBR, was adapted from the National Cancer Institute’s (NCI’s) Young Investigator Award Program. This year, the CPA was bestowed to three research projects pertaining to collaborations between NICBR agencies.

  16. Enterococcus faecalis strains differentially regulate Alix/AIP1 protein expression and ERK 1/2 activation in intestinal epithelial cells in the context of chronic experimental colitis.

    PubMed

    Hoffmann, Micha; Kim, Sandra C; Sartor, R Balfour; Haller, Dirk

    2009-03-01

    Monoassociation of germfree Interleukin 10 gene deficient (IL-10-/-) 129SvEv but not wild-type mice with Enterococcus faecalis induces severe chronic colitis. Bacterial strain-specific effects on the development of chronic intestinal inflammation are not understood. We investigated the molecular mechanisms of E. faecalis OG1RF (human clinical isolate, colitogenic) and E. faecalis ms2 (endogenous isolate from an IL-10-/- mouse) in initiating chronic experimental colitis using IL-10-/- mice. Monoassociation of IL-10-/- mice for 14 weeks revealed significant differences in colonic inflammation (3.6 +/- 0.2 and 2.4 +/- 0.6 for OG1RF and ms2, respectively) (n = 5 mice in each group) (histological scoring (0-4)). Consistent with the tissue pathology, gene expression of the pro-inflammatory chemokine interferon-gamma inducible protein-10 (IP-10) was significantly higher in intestinal epithelial cells (IEC) derived from E. faecalis OG1RF monoassociated IL-10-/- mice. We further compared the differentially E. faecalis induced colitis on the epithelial level by 2D-SDS PAGE coupled with MALDI-TOF MS. Proteome analysis identified 13 proteins which were differentially regulated during disease progression in the epithelium of E. faecalis-monoassociated IL-10-/- mice. Regulation of Alix/AIP1 protein expression and ERK1/2 phosphorylation was validated in primary IEC and epithelial cell lines, suggesting a protective role for Alix/AIP1 in the process of disease progression. Alix/AIP1 protein expression was further characterized in epithelial cell lines using siRNA-mediated knock-down. Our study demonstrates E. faecalis strain-specific induction of colitis in IL-10-/- mice after 14 weeks of monoassociation. Our study suggests that Alix/AIP1 protein expression and ERK1/2 activation are decreased in severe colitis.

  17. Climate Leadership Award for Organizational Leadership

    EPA Pesticide Factsheets

    Apply to the Climate Leadership Award for Organizational Leadership, which publicly recognizes organizations for their comprehensive greenhouse gas inventories and aggressive emissions reduction goals.

  18. Presidential Green Chemistry Challenge: 2009 Academic Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2009 award winner, Professor Krzysztof Matyjaszewski, developed Atom Transfer Radical Polymerization to make polymers with copper catalysts and environmentally friendly reducing agents.

  19. Plant Profiles - Industrial Energy Management in Action

    SciTech Connect

    2001-02-01

    This 24-page brochure profiles industrial manufacturing firms who are achieving significant energy savings in their plants. The DOE Office of Industrial Technologies six plant-of-the-year nominees are featured, and an additional 10 projects from other companies are also highlighted. Information on OIT's awards and recognition process, and information on OIT and BestPractices is also included.

  20. A Comparison of the Astronomy and Astrophysics Abstracts (A&AA) and the American Institute of Physics (AIP) Physics and Astronomy Classification Schemes (PACS)

    NASA Astrophysics Data System (ADS)

    Warren, W. H., Jr.; Lubowic, D. A.

    The astronomy and astrophysics sections of the PACS are used by AIP to classify articles published in AIP, AIP member-society, and Russian translation journals for inclusion in abstract journals or computerized databases, and to prepare subject indexes. PACS has been extensively revised and enhanced over the last several years to become a detailed and flexible scheme designed for simplified and efficient retrieval of published papers from computerized bibliographical databases. We demonstrate the increased resolution and flexibility of the cur- rent PACS by mapping it to the presently-employed A&A classification scheme. We have prepared a concordance table between PACS (and the variant of PACS used for Physics Abstracts) and the A&AA classification scheme. The present PACS is well-suited for database retrieval and will be revised frequently to keep it current with the continuously changing fields of astronomy and astrophysics. We also compare and contrast the 250 PACS categories in astronomy and astrophysics with the alphabetical keyword lists used by A&AA or ApJ (ApJ, MNRAS, and A&A use a unified keyword list) to prepare their subject indexes. An electronic version of our concordance tables will be made available to the astronomical community.

  1. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.

    PubMed

    Bian, Hui; Yu, Long-Chuan

    2015-07-10

    Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine- dependent protein kinase, which has been implicated in pain modulation at different levels of the central nervous system. The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 3 μg, 6 μg and 12 μg of myristoylated autocamtide-2-inhibitory peptide (AIP), the CaMKII inhibitor, dose-dependently increased the HWL to noxious thermal and mechanical stimulation in rats with mononeuropathy. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and AIP group. Taken together, the results showed that intra-NAc injection of AIP induced significant antinociceptive effects in rats with mononeuropathy, indicating that CaMKII may play an important role in the transmission and/or modulation of nociceptive information in the NAc in rats with mononeuropathy.

  2. Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

    PubMed

    Nord, Karolin H; Magnusson, Linda; Isaksson, Margareth; Nilsson, Jenny; Lilljebjörn, Henrik; Domanski, Henryk A; Kindblom, Lars-Gunnar; Mandahl, Nils; Mertens, Fredrik

    2010-12-07

    Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary adenoma predisposition and multiple endocrine neoplasia type I. MEN1 and AIP displayed a low expression in hibernomas whereas the expression of genes up-regulated in brown fat--PPARA, PPARG, PPARGC1A, and UCP1--was high. Thus, loss of MEN1 and AIP is likely to be pathogenetically essential for hibernoma development. Simultaneous loss of two tumor suppressor genes has not previously been shown to result from a neoplasia-associated translocation. Furthermore, in contrast to the prevailing assumption that benign tumors harbor relatively few genetic aberrations, the present analyses demonstrate that a considerable number of chromosome breaks are involved in the pathogenesis of hibernoma.

  3. 7 CFR 2903.17 - Award document and notice of award.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Award document and notice of award. 2903.17 Section 2903.17 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration §...

  4. 7 CFR 2903.17 - Award document and notice of award.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Award document and notice of award. 2903.17 Section 2903.17 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration § 2903...

  5. 7 CFR 2903.17 - Award document and notice of award.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Award document and notice of award. 2903.17 Section 2903.17 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration §...

  6. 7 CFR 2903.17 - Award document and notice of award.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Award document and notice of award. 2903.17 Section 2903.17 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration §...

  7. 7 CFR 2903.17 - Award document and notice of award.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Award document and notice of award. 2903.17 Section 2903.17 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration §...

  8. The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation

    PubMed Central

    Le Clorennec, Christophe; Lazrek, Yassamine; Dubreuil, Olivier; Larbouret, Christel; Poul, Marie-Alix; Mondon, Philippe; Melino, Gerry; Pèlegrin, André; Chardès, Thierry

    2016-01-01

    We characterized the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway, leading to cell cycle arrest and apoptosis in vitro and regression of pancreatic and breast cancer in vivo. We found that 9F7-F11 induces rapid HER3 down-regulation. Specifically, 9F7-F11-induced HER3 ubiquitination and degradation in pancreatic, breast and prostate cancer cell lines was driven mainly by the itchy E3 ubiquitin ligase (ITCH/AIP4). Overexpression of the ITCH/AIP4 inhibitor N4BP1 or small-interfering RNA-mediated knockdown of ITCH/AIP4 inhibited HER3 ubiquitination/degradation and PI3K/AKT signaling blockade induced by 9F7-F11. Moreover, 9F7-F11-mediated JNK1/2 phosphorylation led to ITCH/AIP4 activation and recruitment to HER3 for receptor ubiquitination and degradation. ITCH/AIP4 activity was activated by the deubiquitinases USP8 and USP9X, as demonstrated by RNA interference. Taken together, our results suggest that 9F7-F11-induced HER3 ubiquitination and degradation in cancer cells mainly occurs through JNK1/2-dependent ITCH/AIP4 activation. PMID:27203743

  9. Recommendations from the Italian Interdisciplinary Working Group (AIMN, AIP, SINDEM) for the utilization of amyloid imaging in clinical practice.

    PubMed

    Guerra, Ugo Paolo; Nobili, Flavio Mariano; Padovani, Alessandro; Perani, Daniela; Pupi, Alberto; Sorbi, Sandro; Trabucchi, Marco

    2015-06-01

    Positron emission tomography (PET) of brain amyloid is a technology that has been approved by Food and Drug Administration and European Medical Agency, but its clinical utility in medical practice requires careful definition. To provide guidance to italian dementia care practitioners, patients, and caregivers, a group of experts from "Associazione Italiana di Medicina Nucleare" (AIMN), "Associazione Italiana di Psicogeriatria" (AIP) and "Società Italiana per lo Studio delle Demenze" (SINDEM) convened the Italian Interdisciplinary Working Group on Amyloid Imaging. The Working Group considered a range of clinical scenarios in which amyloid PET should be recommended. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these recommendations. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific recommended use criteria were agreed to define the types of patients and clinical circumstances in which amyloid PET could be used. Both correct and incorrect uses were considered and formulated. Because both dementia care and amyloid-PET technology are in active development, these recommendations will require periodic reassessment.

  10. Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix.

    PubMed

    Urata, Shuzo; Yokosawa, Hideyoshi; Yasuda, Jiro

    2007-07-02

    HTLV-1 Gag protein is a matrix protein that contains the PTAP and PPPY sequences as L-domain motifs and which can be released from mammalian cells in the form of virus-like particles (VLPs). The cellular factors Tsg101 and Nedd4.1 interact with PTAP and PPPY, respectively, within the HTLV-1 Gag polyprotein. Tsg101 forms a complex with Vps28 and Vps37 (ESCRT-I complex) and plays an important role in the class E Vps pathway, which mediates protein sorting and invagination of vesicles into multivesicular bodies. Nedd4.1 is an E3 ubiquitin ligase that binds to the PPPY motif through its WW motif, but its function is still unknown. In the present study, to investigate the mechanism of HTLV-1 budding in detail, we analyzed HTLV-1 budding using dominant negative (DN) forms of the class E proteins. Here, we report that DN forms of Vps4A, Vps4B, and AIP1 inhibit HTLV-1 budding. These findings suggest that HTLV-1 budding utilizes the MVB pathway and that these class E proteins may be targets for prevention of mother-to-infant vertical transmission of the virus.

  11. Abstracts of Phase 1 awards, (fiscal year) 1987

    SciTech Connect

    Not Available

    1987-01-01

    Contained in this booklet are abstracts of the Phase I awards made in Fiscal Year 1987 under the Small Business Innovation Research (SBIR) program in the Department of Energy (DOE). The program is designed for implementation in a three-phase process, with Phase I determining the scientific or technical merit and feasibility of ideas proposed for investigation. The period of performance in this initial phase is relatively brief, typically about 6 months, and the awards are limited to $50,000. Phase II is the principal research or research and development effort, and the awards are as high as $500,000 for work to be performed in periods of up to 2 years. Phase III is the commercial application. The 111 Phase I projects described were selected in a highly competitive process from a total of 942 proposals received in response to the 1987 Solicitation. They cover the fields of chemistry, materials, control systems, plant natural products, instrumentation, nuclear medicine, health and environmental effects, high energy physics, particle accelerators, nuclear physics, plasma diagnostics and confinement, fusion energy systems, robotics and remote systems, nuclear reactors, space nuclear power, fuel cycle, decontamination/decommissioning, commputers in nuclear plants, coal, enhanced oil recovery/tar sands, fossil energy, photovoltaics, solar thermal, ceramics for heat engines, and industrial separation, conversion and recovery processes. (DLC)

  12. NASA Excellence Award for Quality and Productivity 1989 highlights. The 1989 recipient: Lockheed Engineering and Sciences Company

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The NASA Excellence Award for Productivity and Quality is the result of NASA's desire to encourage superior quality and the continuous improvement philosophy in the aerospace industry. It is awarded to NASA contractors, subcontractors, and suppliers who have demonstrated sustained excellence, customer orientation, and outstanding achievements in a total quality management (TQM) environment. The 'highlights' booklet is intended to transfer successful techniques demonstrated by the performance and quality of major NASA contractors.

  13. City of Newport, R.I. Industrial Pretreatment Program Recognized for Excellence

    EPA Pesticide Factsheets

    The Newport, R.I. Water Pollution Control Plant was recently selected by EPA for a 2014 Regional Industrial Pretreatment Program Excellence Award. The pretreatment program staff at the Newport facility, led by Industrial Pretreatment

  14. 28 CFR 345.73 - Procedures for granting awards for suggestions or inventions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... suggestions or inventions. 345.73 Section 345.73 Judicial Administration FEDERAL PRISON INDUSTRIES, INC... for granting awards for suggestions or inventions. Inmate suggestions for improvements in operations... the SOI. (b) The SOI shall ensure that all inmate suggestions and/or inventions formally submitted are...

  15. 34 CFR 379.2 - Who is eligible for a grant award under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Who is eligible for a grant award under this program? 379.2 Section 379.2 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION PROJECTS WITH INDUSTRY...

  16. 40 CFR 35.918-1 - Additional limitations on awards for individual systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... as a minimum, periodic testing of water from existing potable water wells in the area. Where a...-Clean Water Act § 35.918-1 Additional limitations on awards for individual systems. In addition to those... underground potable water sources; (g) Establish a system of user charges and industrial cost recovery in...

  17. 28 CFR 345.73 - Procedures for granting awards for suggestions or inventions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... suggestions or inventions. 345.73 Section 345.73 Judicial Administration FEDERAL PRISON INDUSTRIES, INC... for granting awards for suggestions or inventions. Inmate suggestions for improvements in operations or safety, or for conservation of energy or material, must be submitted in writing. (a) The...

  18. Smith Receives 2008 Walter Sullivan Award for Excellence in Science Journalism-Features

    NASA Astrophysics Data System (ADS)

    Williams, Robyn; Smith, Richard

    2008-07-01

    Richard Smith received the Walter Sullivan Award at the 2008 Joint Assembly Honors Ceremony, which was held on 29 May 2008 in Fort Lauderdale, Fla. Smith was honored for the documentary film ``Crude,'' which examines oil's ancient origins and the geology of its formation and explores the potential, unwelcome consequences of oil's prodigious use by industrial society as a fuel and raw material.

  19. EPA is Accepting Nominations for 2017 Environmental Merit Awards

    EPA Pesticide Factsheets

    The U.S. EPA is now accepting nominations for the 2017 Environmental Merit Awards. Award categories are available for individuals, businesses, governmental entities, and other organizations. Awards are also given under a lifetime achievement category.

  20. Advanced information processing system: Hosting of advanced guidance, navigation and control algorithms on AIPS using ASTER

    NASA Technical Reports Server (NTRS)

    Brenner, Richard; Lala, Jaynarayan H.; Nagle, Gail A.; Schor, Andrei; Turkovich, John

    1994-01-01

    This program demonstrated the integration of a number of technologies that can increase the availability and reliability of launch vehicles while lowering costs. Availability is increased with an advanced guidance algorithm that adapts trajectories in real-time. Reliability is increased with fault-tolerant computers and communication protocols. Costs are reduced by automatically generating code and documentation. This program was realized through the cooperative efforts of academia, industry, and government. The NASA-LaRC coordinated the effort, while Draper performed the integration. Georgia Institute of Technology supplied a weak Hamiltonian finite element method for optimal control problems. Martin Marietta used MATLAB to apply this method to a launch vehicle (FENOC). Draper supplied the fault-tolerant computing and software automation technology. The fault-tolerant technology includes sequential and parallel fault-tolerant processors (FTP & FTPP) and authentication protocols (AP) for communication. Fault-tolerant technology was incrementally incorporated. Development culminated with a heterogeneous network of workstations and fault-tolerant computers using AP. Draper's software automation system, ASTER, was used to specify a static guidance system based on FENOC, navigation, flight control (GN&C), models, and the interface to a user interface for mission control. ASTER generated Ada code for GN&C and C code for models. An algebraic transform engine (ATE) was developed to automatically translate MATLAB scripts into ASTER.

  1. Arvidson Receives 2007 Whipple Award

    NASA Astrophysics Data System (ADS)

    Spohn, Tilman; Arvidson, Raymond E.

    2008-03-01

    The Planetary Sciences section presents with great pleasure the 2007 AGU Whipple Award to Ray Arvidson. Ray has participated in all Mars missions since Viking, and in Magellan. His vigorous and productive career has resulted in nearly 200 peer-reviewed publications on Earth, Mars, Venus, and the Moon, many of which are considered pivotal to our understanding of planetary processes. His topics include remote sensing of planetary surfaces and surface processes; he provided the first quantitative study of aeolian processes on Mars. Ray's contributions are numerous and broadly applied. He played a major role in developing robotic techniques for the in situ exploration of Mars, in particular for the hugely successful MER mission. An AGU Fellow, Ray's work has been recognized by numerous awards in the past. In addition to his scientific work, Ray has provided essential services to the community. His work in pioneering and standardizing planetary data archiving has been particularly recognized as outstanding. He has served on more than 30 NASA committees and was the secretary and the president of the AGU Planetary Sciences section. In addition, he has been an associate editor of JGR and an editor of Geology. He served on the Space Science Board of the National Academy of Sciences and has been chair of its Committee on Data Management and Computation. Enthusiastic support for his nomination came from all over the world.

  2. 40 CFR 35.218 - Award limitation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ASSISTANCE Environmental Program Grants Hazardous Waste Management (section 3011(a)) § 35.218 Award limitation. The Regional Administrator will not award Hazardous Waste Management Grants to a State with interim or final hazardous waste authorization unless the applicant is the lead agency designated in the...

  3. 22 CFR 1509.605 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Award. 1509.605 Section 1509.605 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... Development Foundation or other Federal agency directly to a recipient. (a) The term award includes: (1)...

  4. 46 CFR Sec. 6 - Awarding of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Awarding of work. Sec. 6 Section 6 Shipping MARITIME... of work. (a) Those portions of all bids reflecting the total aggregate cost of the work involved shall be opened publicly. The work shall be awarded to the contractor submitting the lowest qualified...

  5. 2 CFR 175.15 - Award term.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TERM FOR TRAFFICKING IN PERSONS § 175.15 Award term. (a) To implement the trafficking in persons...: I. Trafficking in persons. a. Provisions applicable to a recipient that is a private entity. 1. You... not— i. Engage in severe forms of trafficking in persons during the period of time that the award...

  6. The 1995 Carter G. Woodson Book Awards.

    ERIC Educational Resources Information Center

    Social Education, 1996

    1996-01-01

    Provides concise and interesting reviews of the recipients of the 1995 Carter G. Woodson Book awards. The awards celebrate books for young readers that "treat topics related to ethnic minorities and race relations sensitively and accurately." Reviewed works include biographies of Benjamin Banneker, Marian Anderson, and Harriet Beecher…

  7. 7 CFR 3405.17 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3405.17 Section 3405.17 Agriculture... EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.17 Grant awards. (a) General. Within the limit of funds available for such purpose, the authorized departmental officer shall make project grants...

  8. 7 CFR 3406.24 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3406.24 Section 3406.24 Agriculture... INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Supplementary Information § 3406.24 Grant awards. (a) General... project grants to those responsible, eligible applicants whose proposals are judged most meritorious in...

  9. 7 CFR 3405.17 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3405.17 Section 3405.17 Agriculture... EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.17 Grant awards. (a) General. Within the limit of funds available for such purpose, the authorized departmental officer shall make project grants...

  10. 7 CFR 3406.24 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3406.24 Section 3406.24 Agriculture... INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Supplementary Information § 3406.24 Grant awards. (a) General... project grants to those responsible, eligible applicants whose proposals are judged most meritorious in...

  11. 41 CFR 105-74.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.605 Award. Award... form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program... money. (2) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct...

  12. 41 CFR 105-74.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.605 Award. Award... form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program... money. (2) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct...

  13. 41 CFR 105-74.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.605 Award. Award... form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program... money. (2) Loans. (3) Loan guarantees. (4) Interest subsidies. (5) Insurance. (6) Direct...

  14. Carter G. Woodson Book Awards, 2009

    ERIC Educational Resources Information Center

    Social Education, 2010

    2010-01-01

    In an effort to promote cultural literacy in children and young adults, the Racism and Social Justice Committee of the National Council for the Social Studies created the Carter G. Woodson Book Award. The purpose of the Woodson Award, given annually since 1974, is to promote the writing, publishing, and dissemination of sensitive and accurate…

  15. The First Printz Award Designations: Winners All.

    ERIC Educational Resources Information Center

    Dimmitt, Jean Pollard

    2001-01-01

    Explains a major new book award, the Michael L. Printz Award honoring the best young adult book. Discusses the first prize-winning book: "Monster" by Walter Dean Myers, and three honor books. Discusses how these books are unusual and outstanding examples of young adult literature--structurally sophisticated with memorable characters who deal with…

  16. Kopp Receives 2012 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Kirschvink, Joseph L.

    2013-10-01

    Robert E. Kopp received the 2012 William Gilbert Award at the 2012 AGU Fall Meeting, held 3-7 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  17. 48 CFR 570.308 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... best value after evaluation in accordance with the factors and subfactors in the SFO. (b) Make award in writing and in the timeframe specified in the SFO. (1) If you cannot make an award in that time, request... received in response to an SFO, if doing so is in the best interest of the Government. ...

  18. 32 CFR 644.118 - Awards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Awards. 644.118 Section 644.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Acquisition by Condemnation Proceedings § 644.118 Awards. (a) Approval by Division or District...

  19. 13 CFR 308.2 - Performance awards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Performance awards. 308.2 Section 308.2 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PERFORMANCE INCENTIVES § 308.2 Performance awards. (a) A Recipient of Investment Assistance under parts 305...

  20. 22 CFR 1509.605 - Award.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Award. 1509.605 Section 1509.605 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... Development Foundation or other Federal agency directly to a recipient. (a) The term award includes: (1)...

  1. 22 CFR 1509.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Award. 1509.605 Section 1509.605 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... Development Foundation or other Federal agency directly to a recipient. (a) The term award includes: (1)...

  2. 22 CFR 1509.605 - Award.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Award. 1509.605 Section 1509.605 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... Development Foundation or other Federal agency directly to a recipient. (a) The term award includes: (1)...

  3. 22 CFR 1509.605 - Award.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Award. 1509.605 Section 1509.605 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL... Development Foundation or other Federal agency directly to a recipient. (a) The term award includes: (1)...

  4. 45 CFR 2400.59 - Other awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Other awards. 2400.59 Section 2400.59 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Special Conditions § 2400.59 Other awards. Fellows may accept grants from...

  5. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  6. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  7. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  8. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...

  9. Science and Engineering Doctorate Awards: 1999.

    ERIC Educational Resources Information Center

    Hill, Susan T.

    The data in this report show trends in doctorate awards by science and engineering (S&E) field and recipient characteristics, institutions awarding doctorates, and postgraduation plans of recipients. The source of the data is the Survey of Earned Doctorates (SED). The SED is conducted annually for the National Science Foundation (NSF) and four…

  10. 1966 Architectural Awards. Buildings With Fallout Shelter.

    ERIC Educational Resources Information Center

    Office of Civil Defense (DOD), Washington, DC.

    Award winning designs are presented demonstrating that economical dual-use shelter space can be incorporated in the designs of new buildings without sacrifice of either function or aesthetic values. The eight award winning designs are discussed, and graphic illustration is provided of the nature of dual-use shelter, which contributes to…

  11. 1987 NRSSC Exemplary Program Awards Recipients.

    ERIC Educational Resources Information Center

    Journal of Rural and Small Schools, 1987

    1987-01-01

    Identifies ten recipients of exemplary program awards and describes each program. Award categories include educational technology, cross-cultural services, preserve/inservice training, special education, family/school/community partnerships, innovative and creative programs, secondary curriculum and instruction, at-risk services, elementary…

  12. 42 CFR 67.17 - Grant award.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Grant award. 67.17 Section 67.17 Public Health... FOR HEALTH CARE POLICY AND RESEARCH GRANTS AND CONTRACTS Research Grants for Health Services Research, Evaluation, Demonstration, and Dissemination Projects § 67.17 Grant award. (a) Within the limits of...

  13. 40 CFR 35.548 - Award limitations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Award limitations. 35.548 Section 35.548 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... exceed four years. (d) No award under this program shall result in reduction of total EPA grants...

  14. 48 CFR 922.608-5 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Award. 922.608-5 Section 922.608-5 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Walsh-Healey Public Contracts Act 922.608-5 Award. The...

  15. 46 CFR Sec. 20 - Reports of awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... individually the complete contract number, contractor, vessel, type of award, e.g., negotiated or bid, costs... Contract No. Vessel Award Amount Start Completed Steamboat Repairs, Inc. MA-600 J.O.1 John Doe Bid $15,000 Jan. 1, 1953 Jan. 10, 1953 Steamboat Repairs, Inc MA-600 J.O.1A John Doe Negotiated 1,000 Jan....

  16. TEN MASTER TEACHER AND PROGRAM AWARD PROGRAMS.

    ERIC Educational Resources Information Center

    KOVACH, EDITH M.A.

    IN 1966 THE AMERICAN CLASSICAL LEAGUE HONORED THREE TEACHERS WITH ITS MASTER SECONDARY SCHOOL LATIN TEACHER AND PROGRAM AWARD. AMONG THE 32 PROGRAMS CITED FOR RECOGNITION, TEN (INCLUDING THOSE OF THE AWARD WINNERS) POSSESS CLEARLY INNOVATIVE FEATURES. IN BRIEF THEY FEATURE (1) A FIFTH YEAR ADVANCED PLACEMENT PROGRAM, LATIN AS INTRODUCTORY TO…

  17. 29 CFR 1472.605 - Award.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Award. 1472.605 Section 1472.605 Labor Regulations Relating.... (a) The term award includes: (1) A Federal grant or cooperative agreement, in the form of money or property in lieu of money. (2) A block grant or a grant in an entitlement program, whether or not the...

  18. 23 CFR 1313.8 - Award procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Award procedures. 1313.8 Section 1313.8 Highways NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INCENTIVE GRANT CRITERIA FOR ALCOHOL-IMPAIRED DRIVING PREVENTION PROGRAMS § 1313.8 Award procedures. In each Federal fiscal...

  19. 23 CFR 1313.8 - Award procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Award procedures. 1313.8 Section 1313.8 Highways NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INCENTIVE GRANT CRITERIA FOR ALCOHOL-IMPAIRED DRIVING PREVENTION PROGRAMS § 1313.8 Award procedures. In each Federal fiscal...

  20. Phoenix Award Winners: Books Worth Remembering.

    ERIC Educational Resources Information Center

    Piehl, Kathy

    1998-01-01

    Describes the Phoenix Award, which honors children's books which did not receive an award at publication (20 years in the past), but have withstood the test of time. Presents an annotated bibliography of winning titles under the categories of: Fantasy/Science Fiction; Historical Fiction (British, Depression Era, World War II, Other Wars, Other…

  1. 14 CFR 1274.211 - Award procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for award of a cooperative agreement (regardless of dollar value), if it is thought the agreement may... proposal for an award exceeding $100,000 shall include a certification, and a disclosure form (SF LLL) if... at the NASA center, recipients must furnish an assurance on NASA Form (NF) 1206 on compliance with...

  2. 14 CFR 1274.211 - Award procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for award of a cooperative agreement (regardless of dollar value), if it is thought the agreement may... proposal for an award exceeding $100,000 shall include a certification, and a disclosure form (SF LLL) if... at the NASA center, recipients must furnish an assurance on NASA Form (NF) 1206 on compliance with...

  3. 2004 National Awards for Museum & Library Service

    ERIC Educational Resources Information Center

    Institute of Museum and Library Services, 2004

    2004-01-01

    The National Awards for Museum and Library Service give national recognition to institutions that play an integral and essential part in our learning society. The awards celebrate the efforts of libraries and museums of all sizes to connect with their increasingly diverse communities and to serve as centers of lifelong learning. As the pace of…

  4. 4 CFR 4.4 - Incentive awards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Incentive awards. 4.4 Section 4.4 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM EMPLOYEE PERFORMANCE AND UTILIZATION § 4.4 Incentive awards. The provisions of chapter 45 of title 5, United States Code and Office of Personnel Management implementing...

  5. Science and Engineering Doctorate Awards: 1998.

    ERIC Educational Resources Information Center

    Hill, Susan T.

    The data presented in this report shows trends in doctorate awards by science and engineering (S&E) field and recipient characteristics, institutions awarding doctorates, and postgraduation plans of recipients. The source of the data is the Survey of Earned Doctorates (SED). The SED has been conducted annually for the National Science Foundation…

  6. The 1995 Carter G. Woodson Book Awards.

    ERIC Educational Resources Information Center

    Social Education, 1996

    1996-01-01

    Provides concise and interesting reviews of the recipients of the 1995 Carter G. Woodson Book awards. The awards celebrate books for young readers that "treat topics related to ethnic minorities and race relations sensitively and accurately." Reviewed works include biographies of Benjamin Banneker, Marian Anderson, and Harriet Beecher…

  7. Carter G. Woodson Book Awards, 2009

    ERIC Educational Resources Information Center

    Social Education, 2010

    2010-01-01

    In an effort to promote cultural literacy in children and young adults, the Racism and Social Justice Committee of the National Council for the Social Studies created the Carter G. Woodson Book Award. The purpose of the Woodson Award, given annually since 1974, is to promote the writing, publishing, and dissemination of sensitive and accurate…

  8. 45 CFR 2400.59 - Other awards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Other awards. 2400.59 Section 2400.59 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Special Conditions § 2400.59 Other awards. Fellows may accept grants from...

  9. 45 CFR 2400.59 - Other awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Other awards. 2400.59 Section 2400.59 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Special Conditions § 2400.59 Other awards. Fellows may accept grants from...

  10. Woodhouse receives 2001 Inge Lehmann Award

    NASA Astrophysics Data System (ADS)

    Dziewonski, Adam M.; Woodhouse, John

    John Woodhouse received the Inge Lehmann Award at the 2001 Fall Meeting Honors Ceremony on 12 December, in San Francisco, California. The award is given for outstanding contributions to the understanding of the structure, composition, and dynamics of the Earth's mantle and core.

  11. The European Young Chemist Award 2014.

    PubMed

    Pignataro, Bruno

    2014-12-08

    The future's bright! The European Young Chemist Award for 2014 was awarded at the 5th EuCheMS Chemistry Congress in Instanbul. Impressions and reflections from the Convener of the event, Professor Bruno Pignataro, are given in the Guest Editorial.

  12. 24 CFR 585.202 - Award limits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Award limits. 585.202 Section 585.202 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.202 Award limits. Maximum...

  13. 24 CFR 585.202 - Award limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Award limits. 585.202 Section 585.202 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.202 Award limits. Maximum...

  14. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible... rangeland research project grant under the terms of this part; (ii) Title of project; (iii) Name(s)...

  15. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible, eligible... rangeland research project grant under the terms of this part; (ii) Title of project; (iii) Name(s)...

  16. 42 CFR 64.6 - Awards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Awards. 64.6 Section 64.6 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.6 Awards. (a) Criteria. Within the limits of available funds,...

  17. 42 CFR 64.6 - Awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Awards. 64.6 Section 64.6 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.6 Awards. (a) Criteria. Within the limits of available funds,...

  18. 42 CFR 64.6 - Awards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Awards. 64.6 Section 64.6 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.6 Awards. (a) Criteria. Within the limits of available funds,...

  19. 42 CFR 63a.7 - Awards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Awards. 63a.7 Section 63a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.7 Awards. Criteria. Within the limits of available funds,...

  20. 42 CFR 63a.7 - Awards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Awards. 63a.7 Section 63a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH TRAINING GRANTS § 63a.7 Awards. Criteria. Within the limits of available funds,...