Science.gov

Sample records for aip career pathways

  1. AIP Career Pathways

    NASA Astrophysics Data System (ADS)

    Palchak, Amanda

    2012-02-01

    American Institute of Physics (AIP) Career Pathways is a new project funded by the National Science Foundation. One of the goals of AIP Career Pathways is to prepare students to compete for Science, Technology, Engineering, and Mathematics (STEM) careers with a bachelor's degree in physics. In order to do so, I reviewed and compiled useful resources on finding a STEM career with a bachelor's degree in physics. These resources not only supply the job seeker with job postings in STEM careers but also provide them with information on resumes, interviewing skills, and networking. Recently at the 2011 Industrial Physics Forum, I interviewed companies in the private sector to obtain a unique perspective on what types of skills potential employers expect an applicant to posses with a bachelor's degree in physics. Ultimately, these components will be used as supplements at student career workshops held at annual Society of Physics Students Zone Meetings.

  2. AIP's Career Pathways Project

    NASA Astrophysics Data System (ADS)

    Avila, Jose

    2014-03-01

    The American Institute of Physics (AIP) Career Pathways Project, funded by the National Science Foundation, aims to increase the number of undergraduates going into STEM careers. The main purposes of this project are to show students the professional opportunities for a STEM career, understand what departments can do to better prepare physics bachelor's degree recipients to enter the workforce, understand what students can do to better prepare themselves, and develop resources based on these findings. I was chosen by the Society of Physics Students (SPS) to be the 2013 summer intern of the AIP's Career Pathways Project. In this talk I will discuss several resources I worked on with the Statistical Research Center of the American Institute of Physics and SPS. These resources include how to write a resume and cover letter, how to perform an informational interview, common job titles for physics bachelors, how to find career information in physics and STEM, how to search and use job postings, and how to network.

  3. The AIP career pathways project

    NASA Astrophysics Data System (ADS)

    Sauncy, Toni; Redmond, Kendra; Czujko, Roman

    2015-12-01

    An average 40% of all physics baccalaureate degree recipients in the United States go directly into the work-force rather than entering graduate school. Departments aiming to build robust programs must prepare all students for a broad range of career paths, but the default focus is typically on preparing students for advanced physics degrees. Under-graduate physics programs, with effective recruitment, retention, and appropriate preparation of students, have the potential to add qualified individuals to the STEM workforce. We present results from an investigation to understand, compile, and disseminate effective practices for preparing undergraduate physics students to enter the STEM workforce upon graduation.

  4. Society Membership Profile: Employment Mobility and Career Change. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn; Kellman, Dawn

    Information on the influence of employment mobility and career change on the flexibility of the physics labor force is provided, noting the past several decades have brought a dramatic roller coaster of changes to the physics community. Five sections are as follows: membership composition (demographics, professional self-identification, and…

  5. Career Technical Education Pathways Initiative

    ERIC Educational Resources Information Center

    California Community Colleges, Chancellor's Office, 2013

    2013-01-01

    California's education system--the largest in the United States--is an essential resource for ensuring strong economic growth in the state. The Career Technical Education Pathways Initiative (referred to as the Initiative in this report), which became law in 2005, brings together community colleges, K-12 school districts, employers, organized…

  6. The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.

    PubMed

    Heliövaara, Elina; Raitila, Anniina; Launonen, Virpi; Paetau, Anders; Arola, Johanna; Lehtonen, Heli; Sane, Timo; Weil, Robert J; Vierimaa, Outi; Salmela, Pasi; Tuppurainen, Karoliina; Mäkinen, Markus; Aaltonen, Lauri A; Karhu, Auli

    2009-12-01

    Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to the development of pituitary adenomas. Here, we characterized AIP mutation positive (AIPmut+) and AIP mutation negative (AIPmut-) pituitary adenomas by immunohistochemistry. The expressions of the AIP-related proteins aryl hydrocarbon receptor (AHR), AHR nuclear translocator (ARNT), cyclin-dependent kinase inhibitor 1B encoding p27(Kip1), and hypoxia-inducible factor 1-alpha were examined in 14 AIPmut+ and 53 AIPmut- pituitary adenomas to detect possible expression differences. In addition, the expression of CD34, an endothelial and hematopoietic stem cell marker, was analyzed. We found ARNT to be less frequently expressed in AIPmut+ pituitary adenomas (P = 0.001), suggesting that AIP regulates the ARNT levels. AIP small interfering RNA-treated HeLa, HEK293, or Aip-null mouse embryonic fibroblast cells did not show lowered expression of ARNT. Instead, in the pituitary adenoma cell line GH3, Aip silencing caused a partial reduction of Arnt and a clear increase in cell proliferation. We also observed a trend for increased expression of nuclear AHR in AIPmut+ samples, although the difference was not statistically significant (P = 0.06). The expressions of p27(Kip1), hypoxia-inducible factor 1-alpha, or CD34 did not differ between tumor types. The present study shows that the expression of ARNT protein is significantly reduced in AIPmut+ tumors. We suggest that the down-regulation of ARNT may be connected to an imbalance in AHR/ARNT complex formation arising from aberrant cAMP signaling.

  7. Career Technical Education Pathways Initiative Annual Report

    ERIC Educational Resources Information Center

    California Community Colleges, Chancellor's Office, 2014

    2014-01-01

    California's education system--the largest in the United States--is an essential resource for ensuring strong economic growth in the state. The Career Technical Education Pathways Initiative (the Initiative) became law in 2005 with Senate Bills 70 and 1133 and provided more than $380 million over eight years to improve career technical education…

  8. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.

    PubMed

    Panner, Amith; Crane, Courtney A; Weng, Changjiang; Feletti, Alberto; Fang, Shanna; Parsa, Andrew T; Pieper, Russell O

    2010-06-15

    The antiapoptotic protein FLIP(S) is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homologue (PTEN)-Akt-atrophin-interacting protein 4 (AIP4) pathway regulates FLIP(S) ubiquitination and stability, although the means by which PTEN and Akt were linked to AIP4 activity were unclear. Here, we report that a second regulator of ubiquitin metabolism, the ubiquitin-specific protease 8 (USP8), is a downstream target of Akt, and that USP8 links Akt to AIP4 and the regulation of FLIP(S) stability and TRAIL resistance. In human GBM xenografts, levels of USP8 correlated inversely with pAkt levels, and genetic or pharmacologic manipulation of Akt regulated USP8 levels in an inverse manner. Overexpression of wild-type USP8, but not catalytically inactive USP8, increased FLIP(S) ubiquitination, decreased FLIP(S) half-life, decreased FLIP(S) steady-state levels, and decreased TRAIL resistance, whereas short interfering RNA (siRNA)-mediated suppression of USP8 levels had the opposite effect. Because high levels of the USP8 deubiquitinase correlated with high levels of FLIP(S) ubiquitination, USP8 seemed to control FLIP(S) ubiquitination through an intermediate target. Consistent with this idea, overexpression of wild-type USP8 decreased the ubiquitination of the FLIP(S) E3 ubiquitin ligase AIP4, an event previously shown to increase AIP4-FLIP(S) interaction, whereas siRNA-mediated suppression of USP8 increased AIP4 ubiquitination. Furthermore, the suppression of FLIP(S) levels by USP8 overexpression was reversed by the introduction of siRNA targeting AIP4. These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIP(S) stability and TRAIL sensitivity.

  9. USP8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

    PubMed Central

    Panner, Amith; Crane, Courtney A.; Weng, Changjiang; Feletti, Alberto; Fang, Shanna; Parsa, Andrew T.; Pieper, Russell O.

    2010-01-01

    The anti-apoptotic protein FLIPS is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homolog (PTEN)-Akt-atrophin interacting protein 4 (AIP4) pathway regulates FLIPS ubiquitination and stability, although the means by which PTEN and Akt were linked to AIP4 activity were unclear. We here report that a second regulator of ubiquitin metabolism, the ubiquitin-specific protease (USP) 8, is a downstream target of Akt, and that USP8 links Akt to AIP4 and the regulation of FLIPS stability and TRAIL resistance. In human GBM xenografts, levels of USP8 correlated inversely with pAkt levels, and genetic or pharmacologic manipulation of Akt regulated USP8 levels in an inverse manner. Over-expression of WT USP8, but not catalytically inactive USP8, increased FLIPS ubiquitination, decreased FLIPS half-life, decreased FLIPS steady-state levels, and decreased TRAIL resistance, while siRNA-mediated suppression of USP8 levels had the opposite effects. Because high levels of the USP8 deubiquitinase correlated with high levels of FLIPS ubiquitination, USP8 appeared to control FLIPS ubiquitination through an intermediate target. Consistent with this idea, over-expression of WT USP8 decreased ubiquitination of the FLIPS E3 ubiquitin ligase AIP4, an event previously shown to increase AIP4-FLIPS interaction, while siRNA-mediated suppression of USP8 increased AIP4 ubiquitination. Furthermore, the suppression of FLIPS levels by USP8 over-expression was reversed by introduction of siRNA targeting AIP4. These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIPS stability and TRAIL sensitivity. PMID:20484045

  10. Using Career Pathways to Guide Students through Programs of Study

    ERIC Educational Resources Information Center

    Bragg, Debra D.; Krismer, Marianne

    2016-01-01

    This chapter describes career pathways that evolved through a Trade Adjustment Assistance Community College and Career Training consortium grant designed to help students complete programs of study and enter health care careers.

  11. AIP and its interacting partners.

    PubMed

    Trivellin, Giampaolo; Korbonits, Márta

    2011-08-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to young-onset pituitary tumours, most often to GH- or prolactin-secreting adenomas, and most of these patients belong to familial isolated pituitary adenoma families. The molecular pathway initiated by the loss-of-function AIP mutations leading to pituitary tumour formation is unknown. AIP, a co-chaperone of heat-shock protein 90 and various nuclear receptors, belongs to the family of tetratricopeptide repeat (TPR)-containing proteins. It has three antiparallel α-helix motifs (TPR domains) that mediate the interaction of AIP with most of its partners. In this review, we summarise the known interactions of AIP described so far. The identification of AIP partners and the understanding of how AIP interacts with these proteins might help to explain the specific phenotype of the families with heterozygous AIP mutations, to gain deeper insight into the pathological process of pituitary tumour formation and to identify novel drug targets.

  12. MDRC Research on Career Pathways. Issue Brief

    ERIC Educational Resources Information Center

    Kazis, Richard

    2016-01-01

    As postsecondary credentials have become increasingly important to accessing higher-quality employment, a growing number of education and workforce programs are implementing "career pathways" approaches to help both youth and adults prepare for further education and better jobs. In recent years, the Manpower Demonstration Research…

  13. Career Pathways: What They Are and Why We Need Them

    ERIC Educational Resources Information Center

    Whitaker, Judy

    2008-01-01

    The topic of career pathways has gained momentum across the country. It is the latest effort in the field of career development to assist young people to be able to map out their high school and postsecondary courses of study which will lead them to a meaningful and productive future. Although the philosophy of career pathways has been developing…

  14. The Success of Implementing Programs of Study in Health Careers through Career Clusters and Pathways

    ERIC Educational Resources Information Center

    McCharen, Belinda

    2008-01-01

    As career clusters and pathways are being implemented within the program of study requirement of the Perkins IV legislation, the current linkages between entry level occupations and careers requiring advanced certifications or degrees should be examined by career and technical education (CTE). This study examined the linkage in the healthcare…

  15. Enhancing the Community College Pathway to Engineering Careers

    ERIC Educational Resources Information Center

    Mattis, Mary C., Ed.; Sislin, John, Ed.

    2005-01-01

    Community colleges play an important role in starting students on the road to engineering careers, but students often face obstacles in transferring to four-year educational institutions to continue their education. "Enhancing the Community College Pathway to Engineering Careers," a new book from the National Academy of Engineering and the…

  16. Businesses Partner with Schools, Community to Create Alternative Career Pathways

    ERIC Educational Resources Information Center

    Overman, Stephenie

    2012-01-01

    Business, education and community leaders are working together to create alternative career pathways for young people who are not profiting from the four-year college track. The new Pathways to Prosperity Network brings together the Pathways to Prosperity Project at Harvard Graduate School of Education (HGSE), Jobs for the Future (JFF) and six…

  17. Advancing the educational and career pathway for clinical trials nurses.

    PubMed

    Scott, Kathleen; White, Kathryn; Roydhouse, Jessica K

    2013-04-01

    Clinical trials nurses play a pivotal role in the conduct of clinical research, but the educational and career pathway for these nurses remains unclear. This article reports findings from a survey of nurses working in cancer clinical trials research in Australia. Most participants held postgraduate qualifications (42 of 61); however, clinical trials education was primarily attained through short professional development courses. Interest in pursuing trial-specific postgraduate education was high, but barriers were identified, including cost, time, and unclear benefit for career advancement. Job titles varied substantially, which is indicative of an unclear employment pathway. These findings suggest that initiatives to improve the educational and career pathway for clinical trials nurses are needed and should include the following: formal educational preparation, greater consistency in employment status, and clearer career progression. These strategies should be underpinned by broad professional recognition of the clinical trials nurse as a specialized nursing role.

  18. The Career Pathway Model: Small Steps to Big Leaps

    ERIC Educational Resources Information Center

    Sass, Sharon A.; Pedersen, Ginger L.; Truman, Grace H.

    2007-01-01

    Palm Beach Community College realigned its curriculum to allow students to seamlessly process through career pathways. Students can start in clock-hour-based instruction and transfer that learning into credit-based associate in science degrees. Along this pathway, students can use exit points to employment with recognized certificates.

  19. Report on AIP--1971

    ERIC Educational Resources Information Center

    Physics Today, 1972

    1972-01-01

    The 1971 annual report by the American Institute of Physics (AIP) is highlighted. The report deals with AIP activities during 1971, including changes in publishing methods, new products from the physics-information division, and internal reorganization for better service. (PR)

  20. Approaches to Reflexivity: Navigating Educational and Career Pathways

    ERIC Educational Resources Information Center

    Dyke, Martin; Johnston, Brenda; Fuller, Alison

    2012-01-01

    This paper provides a critical appraisal of approaches to reflexivity in sociology. It uses data from social network research to argue that Archer's approach to reflexivity provides a valuable lens with which to understand how people navigate their education and career pathways. The paper is also critical of Archer's methodology and typology of…

  1. Career Pathways. Trends and Issues Alert No. 20.

    ERIC Educational Resources Information Center

    Wonacott, Michael E.

    New ways of work and new workers and workplaces need education and training systems and occupational classification systems based on the skills that different occupations share rather than on the industry sectors to which they belong. This new approach to providing occupational information (career majors or clusters or pathways) corresponds to…

  2. Career Pathways Partnerships. K-12 & Afterschool Policy Brief

    ERIC Educational Resources Information Center

    Children Now, 2010

    2010-01-01

    On June 30, 2010, California awarded $3 million to support teacher recruitment and training through the California Gang Reduction, Intervention and Prevention (CalGRIP) initiative, which assists young adults at risk of joining gangs in finding employment or pursuing an education. California chose to fund six Career Pathways Partnership projects as…

  3. Programmability in AIPS++

    NASA Technical Reports Server (NTRS)

    Hjellming, R. M.

    1992-01-01

    AIPS++ is an Astronomical Information Processing System being designed and implemented by an international consortium of NRAO and six other radio astronomy institutions in Australia, India, the Netherlands, the United Kingdom, Canada, and the USA. AIPS++ is intended to replace the functionality of AIPS, to be more easily programmable, and will be implemented in C++ using object-oriented techniques. Programmability in AIPS++ is planned at three levels. The first level will be that of a command-line interpreter with characteristics similar to IDL and PV-Wave, but with an intensive set of operations appropriate to telescope data handling, image formation, and image processing. The third level will be in C++ with extensive use of class libraries for both basic operations and advanced applications. The third level will allow input and output of data between external FORTRAN programs and AIPS++ telescope and image databases. In addition to summarizing the above programmability characteristics, this talk will given an overview of the classes currently being designed for telescope data calibration and editing, image formation, and the 'toolkit' of mathematical 'objects' that will perform most of the processing in AIPS++.

  4. Developing a clinical academic career pathway for nursing.

    PubMed

    Coombs, Maureen; Latter, Sue; Richardson, Alison

    Since the publication of the UK Clinical Research Collaboration's (UKRC, 2007) recommendations on careers in clinical research, interest has grown in the concept of clinical academic nursing careers, with increased debate on how such roles might be developed and sustained (Department of Health, 2012). To embed clinical academic nursing roles in the NHS and universities, a clear understanding and appreciation of the contribution that such posts might make to organisational objectives and outcomes must be developed. This paper outlines an initiative to define the potential practice and research contribution of clinical academic roles through setting out role descriptors. This exercise was based on our experience of a clinical academic career initiative at the University of Southampton run in partnership with NHS organisations. Role descriptors were developed by a group of service providers, academics and two clinical academic award-holders from the local programme. This paper outlines clinical academic roles from novice to professor and describes examples of role descriptors at the different levels of a career pathway. These descriptors are informed by clinical academic posts in place at Southampton as well as others at the planning stage. Understanding the nature of clinical academic posts and the contribution that these roles can make to healthcare will enable them to become embedded into organisational structures and career pathways.

  5. Career Pathways: Education with a Purpose

    ERIC Educational Resources Information Center

    Hull, Dan M.

    2004-01-01

    Hot off the press comes the guide to the next generation of education reform. Dan Hull and some of the nation's leading practitioners and educational leaders show how to remake high schools to improve academic outcomes, prepare students for today's high-skills workplace, and motivate them to learn because they see a pathway to their future.…

  6. Pathways to Postsecondary: Indiana Career Majors

    ERIC Educational Resources Information Center

    Schulz, Terri

    2007-01-01

    Education today for the work of tomorrow must take on an entirely new look if the United States is to remain competitive in the global economy. Today, students need to be critical thinkers and problem solvers, have excellent communication and digital literacy skills and master challenging core content. This paper presents "Pathways to…

  7. Reflection: The Early Career Surgeon-Scientist's Pathway to Independence.

    PubMed

    Smith, Stephanie Shintani

    2016-01-01

    The surgeon-scientist offers a unique perspective as one who can arguably best comprehend clinical needs, identify areas ripe for research, and translate discoveries from bench to bedside. However, the long transition from postdoc to independent investigator can prove to be quite challenging. Surgeons have long been described as having results-oriented personalities, and so the long road to independence can be fraught with frustration at times. It requires humility in seeking scientific direction and mentorship, institutional support, and ultimately extramural funding. This reflection piece examines some hallmark steps along the pathway to independence for one otolaryngology-head and neck surgeon-scientist in her early academic career.

  8. Career Pathways and Gender Equity: Providing Opportunities for All Students. Ohio Vocational Sex Equity.

    ERIC Educational Resources Information Center

    Equity Issues, 1998

    1998-01-01

    Career pathways align vocational and academic education within career clusters and provide students new options from grades 9-14. They must have the following elements: industry breadth and depth; opportunities for many populations; career options at entry, technical, and professional levels; and alternative delivery options and academic and…

  9. AIP Member Societies Entering the 1980's. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    Information is presented on the composition of the 1979 membership of the American Institute of Physics (AIP). Questionnaires were administered to members of the nine independent societies of the AIP to determine demographic and employment information. Background characteristics of the membership include the following: more than half identify…

  10. Academic Provenance: Mapping Geoscience Students' Academic Pathways to their Career Trajectories

    NASA Astrophysics Data System (ADS)

    Houlton, H. R.; Gonzales, L. M.; Keane, C. M.

    2011-12-01

    Targeted recruitment and retention efforts for the geosciences have become increasingly important with the growing concerns about program visibility on campuses, and given that geoscience degree production remains low relative to the demand for new geoscience graduates. Furthermore, understanding the career trajectories of geoscience degree recipients is essential for proper occupational placement. A theoretical framework was developed by Houlton (2010) to focus recruitment and retention efforts. This "pathway model" explicitly maps undergraduate students' geoscience career trajectories, which can be used to refine existing methods for recruiting students into particular occupations. Houlton's (2010) framework identified three main student population groups: Natives, Immigrants or Refugees. Each student followed a unique pathway, which consisted of six pathway steps. Each pathway step was comprised of critical incidents that influenced students' overall career trajectories. An aggregate analysis of students' pathways (Academic Provenance Analysis) showed that different populations' pathways exhibited a deviation in career direction: Natives indicated intentions to pursue industry or government sectors, while Immigrants intended to pursue academic or research-based careers. We expanded on Houlton's (2010) research by conducting a follow-up study to determine if the original participants followed the career trajectories they initially indicated in the 2010 study. A voluntary, 5-question, short-answer survey was administered via email. We investigated students' current pathway steps, pathway deviations, students' goals for the near future and their ultimate career ambitions. This information may help refine Houlton's (2010) "pathway model" and may aid geoscience employers in recruiting the new generation of professionals for their respective sectors.

  11. How High School Students Envision Their STEM Career Pathways

    ERIC Educational Resources Information Center

    Zhang, Lin; Barnett, Michael

    2015-01-01

    Given that many urban students exclude Science, Technology, Engineering, and Mathematics careers from their career choices, the present study focuses on urban high school students and adopts the social-cultural approach to understand the following questions: how do students envision their careers? What are the experiences that shape students'…

  12. Advanced Integrated Power Systems (AIPS)

    DTIC Science & Technology

    2012-10-08

    save fuel used for generating electricity in an austere location for a military deployment application. The contractor performed testing of four...45 Appendix B: AIPS Electrical Schematic Diagrams ...................................................................53 LIST OF SYMBOLS...16 Figure 20. Konarka Panel Electrical Grouping

  13. How high school students envision their STEM career pathways

    NASA Astrophysics Data System (ADS)

    Zhang, Lin; Barnett, Michael

    2015-09-01

    Given that many urban students exclude Science, Technology, Engineering, and Mathematics careers from their career choices, the present study focuses on urban high school students and adopts the social-cultural approach to understand the following questions: how do students envision their careers? What are the experiences that shape students' self-reflections? And how do students' self-reflections influence the way they envision their future careers? Five students were interviewed and data were coded in two ways: by topic domains and confidence levels. The research findings indicate that: first, a lack of information about future careers limits students from developing effective strategic plans; second, students' perceived ability to handle situations of potential barriers and communications with their parents might contribute to their certainty about and confidence in future careers.

  14. Effectiveness of Previous Initiatives Similar to Programs of Study: Tech Prep, Career Pathways, and Youth Apprenticeships

    ERIC Educational Resources Information Center

    Lewis, Morgan V.

    2008-01-01

    The federal career and technical legislation reauthorized in 2006 required the recipients of its funding to offer at least one Program of Study (POS). All states have developed some components of POS through earlier initiatives, primarily Tech Prep, career pathways, and youth apprenticeship, that attempted to ease the transition of students from…

  15. A Survey of Career Pathways of Engineering Deans in the United States: Strategies for Leadership Development

    ERIC Educational Resources Information Center

    Hargrove, S. Keith

    2015-01-01

    The career pathways of deans in higher education seem to follow the traditional model in academia from a senior faculty position and/or department chair. This however may be different from deans in engineering education. The goal of this survey research is to assess the career paths of current Deans of Colleges/Schools of Engineering in the United…

  16. Career Pathways of Female High School Principals in the United States

    ERIC Educational Resources Information Center

    Walker, Tiffany Harris

    2013-01-01

    The purpose of this research was to identify the career pathways of female high school principals for women pursuing a career in educational leadership and female leaders interested in obtaining executive level leadership positions. Despite increased enrollment and of women in educational leadership programs, leadership certification programs, and…

  17. Reading and Writing Are Essential Skills for All Educational and Career Pathways

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2008

    2008-01-01

    This newsletter focuses on the importance of reading and writing skills in all educational and career pathways. It includes a variety of strategies for integrating reading and writing skills across the curriculum--in academic, career/technical and fine arts courses--in ways that improve student achievement in reading and writing and in the content…

  18. An Alternative Avenue to Teacher Certification: A Cost Analysis of the Pathways to Teaching Careers Program.

    ERIC Educational Resources Information Center

    Rice, Jennifer King; Brent, Brian O.

    2002-01-01

    Analyzes cost effectiveness of the Pathways to Teaching Careers, a program that supports an alternative route to university-based teacher certification primarily for noncertified teachers, paraprofessionals, and Peace Corps volunteers. (PKP)

  19. States Seek High School Pathways Weaving Academic, Career Options

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2013-01-01

    Every student at Wheeling High School takes a full academic courseload. Many of the graduates of this 2,000-student school in Wheeling, Illinois, however, also emerge with significant experience in a career field. Those interested in health careers, for example, can work with student-athletes in the school's athletic training facility, earn a…

  20. Pathways for foreign-trained dentists to pursue careers in the United States.

    PubMed

    Allareddy, Veerasathpurush; Elangovan, Satheesh; Nalliah, Romesh P; Chickmagalur, Nithya; Allareddy, Veeratrishul

    2014-11-01

    With the U.S. population growing ever more diverse and the need for dentists in many areas of the United States, there is increasing opportunity for foreign-trained dentists to pursue dental careers in this country. This article provides a broad overview of dental education and career pathways available for foreign-trained dentists in the United States. Educational opportunities include pursuing advanced standing dental degree programs and advanced graduate education (residency programs). Career pathways include working in academic and private practice settings. This article also describes the licensure and visa requirements foreign-trained dentists must satisfy to work legally in the United States.

  1. Career and Technical Education as Pathways: Factors Influencing Postcollege Earnings of Selected Career Clusters

    ERIC Educational Resources Information Center

    Compton, Jonathan I.; Laanan, Frankie Santos; Starobin, Soko S.

    2010-01-01

    This study investigated the relationship between student characteristics such as gender, race/ethnicity, program of study, degree completion, and earnings outcomes for students enrolled in career and technical education (CTE) programs within the business, information technology (IT), and marketing career clusters in community colleges to determine…

  2. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.

    PubMed

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-08-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15-40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and beta-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6+/-11.2 years) than AIP mutation-negative patients (40.4+/-14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein-protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants.

  3. Characterization of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Mutations in Familial Isolated Pituitary Adenoma Families

    PubMed Central

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-01-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15–40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and β-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6±11.2 years) than AIP mutation-negative patients (40.4±14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein–protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants. Hum Mutat 31:1–11, 2010. © 2010 Wiley-Liss, Inc. PMID:20506337

  4. AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.

    PubMed

    Lecoq, Anne-Lise; Viengchareun, Say; Hage, Mirella; Bouligand, Jérôme; Young, Jacques; Boutron, Audrey; Zizzari, Philippe; Lombès, Marc; Chanson, Philippe; Kamenický, Peter

    2016-05-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenobiotics implicated in carcinogenesis. As 75% of AIP mutations disrupt the physical and/or functional interaction with AhR, we postulated that the tumorigenic potential of AIP mutations might result from altered AhR signaling. We evaluated the impact of AIP mutations on the AhR signaling pathway, first in fibroblasts from AIP-mutated patients with pituitary adenomas, by comparison with fibroblasts from healthy subjects, then in transfected pituitary GH3 cells. The AIP protein level in mutated fibroblasts was about half of that in cells from healthy subjects, but AhR expression was unaffected. Gene expression analyses showed significant modifications in the expression of the AhR target genes CYP1B1 and AHRR in AIP-mutated fibroblasts, both before and after stimulation with the endogenous AhR ligand kynurenine. Kynurenine increased Cyp1b1 expression to a greater extent in GH3 cells overexpressing wild type compared with cells expressing mutant AIP Knockdown of endogenous Aip in these cells attenuated Cyp1b1 induction by the AhR ligand. Both mutant AIP expression and knockdown of endogenous Aip affected the kynurenine-dependent GH secretion of GH3 cells. This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR transcriptional activity in a gene- and tissue-dependent manner.

  5. Advanced Information Processing System (AIPS)

    NASA Technical Reports Server (NTRS)

    Pitts, Felix L.

    1993-01-01

    Advanced Information Processing System (AIPS) is a computer systems philosophy, a set of validated hardware building blocks, and a set of validated services as embodied in system software. The goal of AIPS is to provide the knowledgebase which will allow achievement of validated fault-tolerant distributed computer system architectures, suitable for a broad range of applications, having failure probability requirements of 10E-9 at 10 hours. A background and description is given followed by program accomplishments, the current focus, applications, technology transfer, FY92 accomplishments, and funding.

  6. Career options.

    PubMed

    2011-06-24

    Practitioners at all levels can plan their future career options through the NHS Nursing Career Framework interactive tool. The tool builds on the pathway-based framework set out in the post-registration career framework for nurses. Career pathways are outlined under each branch and the specialties within the branches, and cover topics including clinical careers, management and moving into education or research.

  7. Employment Survey 1976. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    This document presents the summary results of the 1976 employment survey of physics and astronomy graduates of the class of 1975-76 as conducted by the American Institute of Physics (AIP). Data presented include employment status 6-18 months after graduation; background characteristics of doctoral, master's and bachelor's level physicists; time…

  8. Aligning K-12 and Postsecondary Career Pathways with Workforce Needs

    ERIC Educational Resources Information Center

    Zinth, Jennifer

    2015-01-01

    Since 2013, states have witnessed significant legislative activity related to secondary- and postsecondary-level career/technical education (CTE). One key goal of much recent policymaking activity has been to improve alignment between high school and postsecondary CTE programs, including by developing state or regional structures to design career…

  9. Creative Work Careers: Pathways and Portfolios for the Creative Economy

    ERIC Educational Resources Information Center

    Ashton, Daniel

    2015-01-01

    This article examines the career opportunities, challenges and trajectories of creative work. As part of the Creative Trident approach to creative workforce measurements, the embedded mode draws attention to creative work as it is undertaken outside of the creative industries. This article further considers and conceptualises the complex careers…

  10. New Pathways to Careers and College: Examples, Evidence, and Prospects

    ERIC Educational Resources Information Center

    Visher, Mary G.; Stern, David

    2015-01-01

    The debate about high school reform is increasingly focused on the role of career-technical education (CTE) in helping to prepare "all" students for success in "both" postsecondary education and the workforce. The stand-alone vocational courses into which high school students with lower academic achievement were often channeled…

  11. PATHWAYS TO HEALTH CAREERS, EXPLORING HEALTH OCCUPATIONS AND PROFESSIONS.

    ERIC Educational Resources Information Center

    Health Careers Council of Illinois, Chicago.

    CAREERS IN THE AREAS OF DENTISTRY, DIETETICS, MEDICAL RECORD LIBRARY SCIENCE, MEDICAL LABORATORY WORK, MEDICINE, NURSING, OCCUPATIONAL THERAPY, OPTOMETRY, PHARMACY, PHYSICAL THERAPY, PODIATRY, PUBLIC HEALTH, RADIOLOGIC TECHNOLOGY, SOCIAL WORK, VETERINARY MEDICINE, HOSPITAL ADMINISTRATION, AND OTHER HEALTH OCCUPATIONS ARE DESCRIBED IN TERMS OF THE…

  12. Aip regulates cAMP signalling and GH secretion in GH3 cells.

    PubMed

    Formosa, R; Xuereb-Anastasi, A; Vassallo, J

    2013-08-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked to predisposition to pituitary adenomas. However, the mechanism by which this occurs remains unknown. AIP interacts with a number of interesting proteins, including members of the cAMP signalling pathway that has been shown to be consistently altered in pituitary tumours. The functional role of Aip was investigated using both over-expression and knock down of Aip in GH3 cells. cAMP signalling and its downstream effectors, including GH secretion, were then investigated. cAMP signalling was analysed using cAMP assays, cAMP-response element-promoter luciferase reporter assays, real-time PCR and finally secreted GH quantification. Over-expression of wild-type (WT)-Aip reduced forskolin-induced cAMP signalling at the total cAMP level, luciferase reporter activity and target gene expression, when compared with empty vector and the non-functional R304X mutant. Additionally, GH secretion was reduced in WT-Aip over-expressing GH3 cells treated with forskolin. Knock down of endogenous Aip resulted in increased cAMP signalling but a decrease in GH secretion was also noted. Inhibition of phosphodiesterase activity using general and selective inhibitors did not completely ablate the effect of Aip on forskolin-augmented cAMP signalling. A mechanism by which Aip acts as a tumour suppressor, by maintaining a low cAMP signalling and concentration, is suggested. Mutations of Aip render the protein incapable of such activity. This effect appears not to be mediated by the AIP-PDE interaction, suggesting the involvement of other interacting partners in mediating this outcome.

  13. A Comparison of Career Technical Education--16 Career Pathway High School Participants with Non-Participants on Academic Achievement, School Engagement, and Development of Technical Skills

    ERIC Educational Resources Information Center

    Orozco, Edith Aimee

    2010-01-01

    The objective of this research was to compare Career Technical Education--16 Career Pathway high school participants with non-participants on academic achievement, development of technical skills and school engagement. Academic achievement was measured by Exit Level Math and English Language Arts Texas Assessment of Knowledge and Skills (TAKS)…

  14. A Cross-Case Analysis of Career Pathway Programs That Link Low-Skilled Adults to Family-Sustaining Wage Careers. In Brief

    ERIC Educational Resources Information Center

    Bragg, Debra D.; Bremer, Christine D.; Castellano, Marisa; Kirby, Catherine; Mavis, Ann; Schaad, Donna; Sunderman, Judith

    2007-01-01

    Little is known about educational programs referred to as "career pathway programs" that attempt to integrate adult literacy, adult basic education (ABE), General Equivalency Diploma (GED) instruction, English language literacy (ELL), and pre-collegiate developmental education with postsecondary career and technical education (CTE)…

  15. Beyond Tracking: Multiple Pathways to College, Career, and Civic Participation

    ERIC Educational Resources Information Center

    Oakes, Jeannie, Ed.; Saunders, Marisa, Ed.

    2008-01-01

    "Beyond Tracking" responds to the a sobering assessment of American high schools by delineating and promoting an innovative and well-defined notion of multiple pathways. The book's authors clearly distinguish their use of the term "multiple pathways" from any updated version of the tracking system that marked so many American high schools during…

  16. Career Pursuit Pathways among Emerging Adult Men and Women: Psychosocial Correlates and Precursors

    ERIC Educational Resources Information Center

    Shulman, Shmuel; Barr, Tamuz; Livneh, Yaara; Nurmi, Jari-Erik; Vasalampi, Kati; Pratt, Michael

    2015-01-01

    The present study examined career pursuit pathways in 100 Israeli emerging adults (54 men) who were followed from age 22 to 29. Employing a semi-structured interview at the age of 29, participants were asked about current work and educational status, work and educational goals and status changes in recent years, and to reflect on the meaning of…

  17. Building a Strong Relationship between Competency-Based Pathways and Career Technical Education

    ERIC Educational Resources Information Center

    Kreamer, Kate Blosveren; Zimmermann, Andrea

    2015-01-01

    Competency-based pathways (CBP) have the potential to open new opportunities for students to learn and demonstrate their learning in meaningful ways that are grounded in application and relevant to their career goals. This brief argues that states can and should leverage CTE when considering how to move K-12 education toward a system marked by…

  18. Career Pathways of Athletic Directors: Consideration of the Impact of Diversity

    ERIC Educational Resources Information Center

    Armstrong, Lenora E.

    2011-01-01

    This study explored career pathways for becoming an athletic director (AD) at National Collegiate Athletic Association (NCAA) Divisions I, II, and, III member institutions with consideration of gender and race/ethnicity. The study employed an exploratory, descriptive research design using a quantitative electronic survey tapping a census of all…

  19. The Pathways Framework Meets Consumer Culture: Young People, Careers, and Commitment

    ERIC Educational Resources Information Center

    Vaughan, Karen

    2005-01-01

    This article engages with current debates in New Zealand over the legitimacy of various young people's activities within a transition-to-work framework based around the metaphor of "pathways". The article argues for a more complex understanding of the imperatives young people now face in choosing careers within a deregulated, seamless…

  20. Are Green Jobs Career Pathways a Path to a 21st-Century Workforce Development System?

    ERIC Educational Resources Information Center

    Scully-Russ, Ellen

    2013-01-01

    This article examines policy reports that advocate for new green jobs career pathways to help grow the green economy and create new opportunity structures in the green labor market. The reports are based on a series of propositions about the nature of green jobs and the existence of the political will to invest in new green education programs to…

  1. Pathways for Academic Career and Employment (PACE) Program: Fiscal Year 2015 Report

    ERIC Educational Resources Information Center

    Iowa Department of Education, 2016

    2016-01-01

    The pathways for academic career and employment program (PACE) is established to provide funding to community colleges for the development of projects that will lead to gainful, quality, in-state employment for members of target populations by providing them with both effective academic and employment training to ensure gain. This is the second…

  2. Pathways for Academic Career and Employment (PACE) Program: Fiscal Year 2014 Report

    ERIC Educational Resources Information Center

    Iowa Department of Education, 2014

    2014-01-01

    Community colleges across Iowa are working with business and industry through sector boards to develop training programs for jobs that have applicant shortages. The state Pathways for Academic Career and Employment (PACE) program enables community colleges to offer in-demand training, making education affordable for low income or unemployed…

  3. The Pursuit of Pathways: Combining Rigorous Academics with Career Training

    ERIC Educational Resources Information Center

    Schwartz, Robert B.

    2014-01-01

    In February 2011 author Robert Schwartz, along with with two colleagues--economist Ronald Ferguson and journalist William Symonds--released a report, "Pathways to Prosperity: Meeting the Challenge of Preparing Young Americans for the 21st Century," which was published by Harvard University's Graduate School of Education. When they…

  4. The Integral Role of Career Development in Supporting Programs of Study and Career Pathways. Transition Highlights. Issue 1

    ERIC Educational Resources Information Center

    Kalchik, Stephanie; Oertle, Kathleen

    2010-01-01

    According to Sears (1982), career development is "the total constellation of economic, sociological, psychological, educational, physical, and chance factors that combine to shape one's career." This definition was advanced by the Illinois Career Development Task Force that engaged in more than a year of deliberation. Career development…

  5. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.

    PubMed

    Ferguson, Annabel A; Springer, Mitchell G; Fisher, Alfred L

    2010-06-01

    Maintenance of a stable, properly folded, and catalytically active proteome is a major challenge to organisms in the face of multiple internal and external stresses which damage proteins and lead to protein misfolding. Here we show that internal metabolic stress produced by reactive intermediates resulting from tyrosine degradation triggers the expression of the aip-1 gene, which is critical in responses to the environmental toxin arsenic and the clearance of unstable polyglutamine and Abeta proteins. aip-1 acts via binding to the proteosome and enhancing proteosomal function. We find that full induction of aip-1 depends on the oxidative-stress-responsive skn-1 transcription factor but significant induction still occurs without skn-1. Importantly, activation of skn-1 with wdr-23(RNAi), which dramatically induces the expression of other skn-1 target genes, produces a minimal increase in aip-1 expression. This suggests that the previously demonstrated specificity in aip-1/AIRAP induction could reflect the actions of multiple synergistic activators, such as the heat shock factor homolog hsf-1, which we also find is required for full induction. These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways.

  6. Educators' expectations of roles, employability and career pathways of registered and enrolled nurses in Australia.

    PubMed

    Jacob, Elisabeth R; McKenna, Lisa; D'Amore, Angelo

    2016-01-01

    In Australia, like other countries, two levels of nurse are registered for entry to practice. Educational changes for second level nurses in Australia have led to questions regarding roles and career options. This paper reports on interviews with nursing course coordinators to examine educator expectations of roles and career pathways of registered and enrolled nurses. Coordinators of eight degree (registered) and diploma (enrolled) nursing programs were interviewed to determine their opinions on roles and careers that students were prepared for. Transcripts were thematically analysed. Educators reported similar graduate roles, although high acuity care was primarily the role of registered nurses. Career expectations differed with enrolled nurses having limited advancement opportunity, and registered nurses greater career options. Health organisations were unprepared to accommodate increased practice scope of enrolled nurses and limited work practice through policies stipulating who could perform procedures. Organisational health policies need to accommodate increased enrolled nurse skill base. Education of practising nurses is necessary regarding increased scope of enrolled nurse practice to ensure they are used to their full potential. Increasing patient acuity requires more registered nurses, as enrolled nurses are unprepared to care for complex or deteriorating patients.

  7. AIP Member Societies Entering the 1980's.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    1981-01-01

    Summarizes results of a survey conducted by the Manpower Statistics Division of the American Institute of Physics (AIP). Questions were asked of nine member societies of the AIP concerning demographic and employment data such as professional self-identification, type of employer by highest degree, primary work activity, and annual salary. (CS)

  8. Farther, Faster: Six Promising Programs Show How Career Pathway Bridges Help Basic Skills Students Earn Credentials That Matter

    ERIC Educational Resources Information Center

    Strawn, Julie

    2011-01-01

    Students forced to complete a long sequence of remedial or English language classes before they can begin their postsecondary program rarely earn college certificates or degrees. This brief highlights six promising programs that show how career pathway bridges help lower-skilled students move farther and faster along college and career paths…

  9. Longitudinal Data Collection in Career Pathways Programs: Core Indicators and Elements. Policy Brief

    ERIC Educational Resources Information Center

    Chisman, Forrest; Murphy, Garrett; Parker, James; Spangenberg, Gail

    2010-01-01

    The goal of any career pathways programs is to provide low-skilled individuals with the education and training they need to move from their present level(s) of skills and abilities to the level(s) required to hold family-supporting jobs. While far from a definitive statement on the subject, this four-page Policy Brief offers a brief discussion and…

  10. Aligning Athletes' Career Choices and Graduate Degree Pathways: Implications for 21st-Century Career Development Professionals

    ERIC Educational Resources Information Center

    Haslerig, Siduri J.; Navarro, Kristina M.

    2016-01-01

    Higher education career development professionals are charged with more than understanding the challenges and needs of a diverse student body, and they must also prepare students for career fields in life after higher education. This empirical study explored the graduate degree choices and career aspirations of 14 college athletes who competed in…

  11. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

    PubMed

    Johnson, Jeffrey G; Wang, Boyuan; Debelouchina, Galia T; Novick, Richard P; Muir, Tom W

    2015-05-04

    The agr locus in the commensal human pathogen, Staphylococcus aureus, is a two-promoter regulon with allelic variability that produces a quorum-sensing circuit involved in regulating virulence within the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentrations by AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global changes in gene expression. The finding that staphylococcal virulence can be inhibited through antagonism of this quorum-sensing pathway has fueled tremendous interest in understanding the structure-activity relationships underlying the AIP-AgrC interaction. The defining structural feature of the AIP is a 16-membered, thiolactone-containing macrocycle. Surprisingly, the importance of ring size on agr activation or inhibition has not been explored. In this study, we address this deficiency through the synthesis and functional analysis of AIP analogues featuring enlarged and reduced macrocycles. Notably, this study is the first to interrogate AIP function by using both established cell-based reporter gene assays and newly developed in vitro AgrC-I binding and autophosphorylation activity assays. Based on our data, we present a model for robust agr activation involving a cooperative, three-points-of-contact interaction between the AIP macrocycle and AgrC.

  12. Tracking Geoscience Pathways from the Undergraduate Degree through the Years as an Early Career Geoscientist (Invited)

    NASA Astrophysics Data System (ADS)

    Wilson, C. E.; Keane, C. M.; Houlton, H. R.

    2013-12-01

    The American Geosciences Institute's Workforce Program has recently launched AGI's Geoscience Student Exit Survey and the Survey of the Geoscience Workforce in an effort to provide more detailed information about the career pathways of early career geoscientists from their undergraduate degree through their first five years in the workforce. These surveys are attempting to answer long unknown questions related to the motivations of students for majoring in the geosciences, their experiences while working towards the degree, their future plans immediately after finishing their terminal degree, and their development in the workforce as they establish themselves in a career. With these surveys, AGI will be able to provide a more in depth presentation of the supply, demand, and human dynamics of the geoscience workforce. We find this effort to be very timely with the increased national focus on the STEM workforce, as well as recent discussions within the geosciences community requesting more information about the students' transition into the workforce after graduation. For AGI to be successful in this project, we need the support of geoscience departments nationally and internationally.

  13. Pathways to economic opportunity: an overview of innovative career pathway collaborations for Latinos into frontline health care occupations.

    PubMed

    De Jesús, Anthony; Torres, Andrés; Rivera, Carmen Vivian

    2014-01-01

    Extraordinary Latino population growth has created demand for bilingual and culturally competent frontline health care providers to address the "culture gap" in health care delivery meeting the linguistic and cultural needs of Latino communities (Cohen, Gabriel, & Terrell, 2002). This article reviews career pathway programs that serve as workforce development models for Latinos seeking opportunity within frontline health care occupations, a sector with high-projected employment growth in the coming decade. The programs examined reflect innovative approaches that target Latino participants for entrance into some of these occupations including registered nurses (RNs), licensed practical nurses (LPNs), human service assistants, and bachelor's level social worker positions that offer low-wage Latinos the possibility of entering a profession where they may earn a livable wage. Implications for policy, research, and practice are discussed.

  14. Long-term Academic and Career Impacts of Undergraduate Research: Diverse Pathways to Geoscience Careers Following a Summer Atmospheric Science Research Internship

    NASA Astrophysics Data System (ADS)

    Trott, C. D.; Sample McMeeking, L. B.; Boyd, K.; Bowker, C.

    2015-12-01

    Research experiences for undergraduates (REU) have been shown to support the success of STEM undergraduates through improving their research skills, ability to synthesize knowledge, and personal and professional development, all while socializing them into the nature of science. REUs are further intended to support STEM career choice and professional advancement, and have thus played a key role in diversity efforts. Recruiting and retaining diverse students in STEM through REUs is of particular importance in the geosciences, where women and ethnic minorities continue to be significantly underrepresented. However, few studies have examined the long-term impacts of these REUs on students' academic and career trajectories. Further, those that do exist primarily study the experiences of current graduate students, scientists, and faculty members—that is, those who have already persisted—which overlooks the multiple academic and career paths REU students might follow and may preclude a thorough examination of REUs' diversity impacts. In this long-term retrospective study of the academic and career impacts of a REU program at a large Western U.S. research university, we interviewed 17 former REU participants on their expectations prior to their REU participation, their experiences during the REU, the immediate outcomes from the experience, and its long-term impacts on their academic and career choices. To address gaps in the existing literature on REU impacts, we purposively sampled students who have taken a variety of educational and career paths, including those not engaged in science research. Despite varied trajectories, the majority of the students we interviewed have persisted in the geosciences and attest to the REU's profound impact on their career-related opportunities and choices. This presentation describes students' diverse STEM pathways and discusses how students' REU expectations, experiences, and immediate outcomes continued to make an impact long-term.

  15. The AIP (aryl hydrocarbon receptor-interacting protein) gene and its relation to the pathogenesis of pituitary adenomas.

    PubMed

    Lloyd, Catrin; Grossman, Ashley

    2014-08-01

    Pituitary adenomas are monoclonal neoplasms that may secrete excessive quantities of their endogenous hormones, or may not be associated with any obvious syndrome, in which case they are known as non-functioning pituitary adenomas. Around 2 % have been said to occur in a familial setting, in the absence of any other tumor, now described as familial isolated pituitary adenomas (FIPA). Some 15-30 % of such families harbor inactivating germ-line mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene, along with 20 % of pediatric seemingly sporadic cases. AIP mutants are referred to as having pituitary adenoma predisposition, and present with early onset, aggressive macroadenomas, most of which secrete somatotropin. Evidence from transfection studies implies that AIP acts as a tumor suppressor; although whether this is mediated through an interaction with the aryl hydrocarbon receptor, phosphodiesterases, or with cell cycle regulators such as survivin or RET remains controversial. However, at present an interaction with the cyclic AMP pathway seems most plausible. Recently, evidence has shown that AIP may act at the cell surface, causing changes in integrin function. The presence of AIP mutations in a significant proportion of FIPA families as well as in apparently sporadic cases, particularly in young patients, suggests a need to screen such patients for AIP mutations to enable better clinical management. However, the absence of AIP mutations in over half of such cases highlights the need to search for further gene mutations.

  16. AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic responses

    PubMed Central

    Zhou, Huanjiao Jenny; Chen, Xiaodong; Liu, Renjing; Zhang, Haifeng; Wang, Yingdi; Jin, Yu; Liang, Xiaoling; Lu, Lin; Xu, Zhe; Min, Wang

    2014-01-01

    Objective To investigate the novel function of AIP1 in VEGFR-3 signaling, and VEGFR-3-dependent angiogenesis and lymphangiogenesis. Approach/Results AIP1, a signaling scaffold protein, is highly expressed in the vascular endothelium. We have previously reported that AIP1 functions as an endogenous inhibitor in pathological angiogenesis by blocking VEGFR-2 activity. Surprisingly, here we observe that mice with a global deletion of AIP1 (AIP1-KO) exhibit reduced retinal angiogenesis with less sprouting and fewer branches. Vascular endothelial cell (but not neuronal)-specific deletion of AIP1 causes similar defects in retinal angiogenesis. The reduced retinal angiogenesis correlates with reduced expression in VEGFR-3 despite increased VEGFR-2 levels in AIP1-KO retinas. Consistent with the reduced expression of VEGFR-3, AIP1-KO mice show delayed developmental lymphangiogenesis in neonatal skin and mesentery, and mount weaker VEGF-C-induced cornea lymphangiogenesis. In vitro, human lymphatic EC with AIP1 siRNA knockdown, retinal EC and lymphatic EC isolated from AIP1-KO all show attenuated VEGF-C-induced VEGFR-3 signaling. Mechanistically, we demonstrate that AIP1 via vegfr-3-specific miR-1236 increases VEGFR-3 protein expression, and by directly binding to VEGFR-3 enhances VEGFR-3 endocytosis and stability. Conclusion Our in vivo and in vitro results provide the first insight into the mechanism by which AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic signaling. PMID:24407031

  17. Basic Education for Adults: Pathways to College and Careers for Washington's Emerging Workforce. Washington's Community and Technical Colleges

    ERIC Educational Resources Information Center

    Washington State Board for Community and Technical Colleges, 2015

    2015-01-01

    This brief describes the Basic Education for Adults (BEdA) programs that bridge the gap between school and work, thereby creating pathways to college and careers for Washington's emerging workforce. BEdA programs teach foundational skills--reading, writing, math, technology and English language--so adults can move through college and into…

  18. Career Pathways of Teacher Leaders in the United States: Adding and Path-Finding New Professional Roles

    ERIC Educational Resources Information Center

    Eckert, Jonathan; Ulmer, Jasmine; Khachatryan, Edit; Ledesma, Patrick

    2016-01-01

    This study examines how participation in a US Department of Education policy fellowship influenced the career pathways of teacher leaders. This sample of teacher leaders is illustrative of teacher leadership development beyond the classroom and demonstrates challenges and opportunities. Notably, 64% of participants reported changing their…

  19. Career Pathways for a Productive and Self-Reliant Workforce: A To-Do List for Adult Educators

    ERIC Educational Resources Information Center

    Jurmo, Paul

    2011-01-01

    The adult basic education field in the United States is now being encouraged to shift to a "career pathways" orientation by policy research organizations, federal and state agencies, community college organizations, business groups, and private foundations. In such an approach, adult basic education programs work with workforce…

  20. Bachelor's Degree Recipients Report 1995. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Dodge, Elizabeth

    This document reports on a 1995 survey of students graduating with a bachelor's degree in physics or astronomy as part of an ongoing series of surveys that have been conducted by the American Institute of Physics (AIP) since the 1960s. The data obtained on the 1995 class build upon established trends in students' immediate postbaccalaureate plans…

  1. Contributing Factors in Students' Choice of a Physical Therapist Assistant Career: A Contrast with the Physical Therapist Career Pathway

    ERIC Educational Resources Information Center

    Mele, Robert V.

    2009-01-01

    The health care professions have gained significant notoriety as one of the fastest growing career opportunities in the country. In particular, physical therapy has gained a reputation as a vital and significant member of the health care team. The physical therapy field has struggled to provide adequate services to meet patients' needs due to the…

  2. The Relationship of Individual Career Plans to Programs of Study and Career Pathways. Transition Highlights. Issue 3

    ERIC Educational Resources Information Center

    Kalchik, Stephanie; Oertle, Kathleen Marie

    2011-01-01

    Emerging in the late 1960s and early 1970s, the concept of individual student planning developed as a component of school guidance counseling programs. The underlying significance of these plans, such as the Individual Career Plan (ICP), is that "it gives [students] a chance to tell and develop their story" (N. Gysbers, personal communication,…

  3. Career Pathways, Academic Performance, and Transition to College and Careers: The Impact of Two Select Career and Technical Education (CTE) Transition Programs on Student Outcomes. In Brief

    ERIC Educational Resources Information Center

    Bragg, Debra D.; Ruud, Collin M.

    2007-01-01

    This brief summarizes results of a recently published study that examined the effects of career and technical education (CTE) transition programs on student matriculation from secondary to postsecondary education. The study was divided into two components. One focused on secondary institutions' CTE transition programs and their effects on…

  4. Mastering Physics for Non-Academic Careers. AIP Report.

    ERIC Educational Resources Information Center

    Norton, Stephen D.; Hammer, Philip W.; Czujko, Roman

    A detailed analysis was conducted of all master's degree programs in physics in the United States, including those that offer a master's as their highest physics program and those that have a master's program in parallel with the Ph.D. program. Data were collected from colleges and universities with master's degree programs and through phone…

  5. The Early Careers of Physics Bachelors. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie

    This report focuses on graduates in physics who did not earn any degrees after their bachelor's degree and who are not primarily students. The report is based on data from a sample of physics bachelors between December 1998 and the summer of 1999. About 1,200 respondents, out of a potential 2,400, supplied the information. At 5 to 8 years after…

  6. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity

    PubMed Central

    Kiefer, Christian S.; Claes, Andrea R.; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity. PMID:25428588

  7. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    PubMed

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.

  8. Validation environment for AIPS/ALS: Implementation and results

    NASA Technical Reports Server (NTRS)

    Segall, Zary; Siewiorek, Daniel; Caplan, Eddie; Chung, Alan; Czeck, Edward; Vrsalovic, Dalibor

    1990-01-01

    The work is presented which was performed in porting the Fault Injection-based Automated Testing (FIAT) and Programming and Instrumentation Environments (PIE) validation tools, to the Advanced Information Processing System (AIPS) in the context of the Ada Language System (ALS) application, as well as an initial fault free validation of the available AIPS system. The PIE components implemented on AIPS provide the monitoring mechanisms required for validation. These mechanisms represent a substantial portion of the FIAT system. Moreover, these are required for the implementation of the FIAT environment on AIPS. Using these components, an initial fault free validation of the AIPS system was performed. The implementation is described of the FIAT/PIE system, configured for fault free validation of the AIPS fault tolerant computer system. The PIE components were modified to support the Ada language. A special purpose AIPS/Ada runtime monitoring and data collection was implemented. A number of initial Ada programs running on the PIE/AIPS system were implemented. The instrumentation of the Ada programs was accomplished automatically inside the PIE programming environment. PIE's on-line graphical views show vividly and accurately the performance characteristics of Ada programs, AIPS kernel and the application's interaction with the AIPS kernel. The data collection mechanisms were written in a high level language, Ada, and provide a high degree of flexibility for implementation under various system conditions.

  9. Skills for Life Teachers' Career Pathways in the Learning and Skills Sector, 2004-2007: Part-Time Jobs for Part-Time Workers

    ERIC Educational Resources Information Center

    Swain, Jon Michael; Cara, Olga

    2010-01-01

    This paper is based on findings from a three-year longitudinal study in England called the Teacher Study which aimed to provide an analytical description of who Skills for Life (SfL) teachers are and what they do in their working lives. The main focus of the paper is teachers' career pathways and the possibilities of making a career in…

  10. Immunogenetics of IgG4-Related AIP.

    PubMed

    Ota, Masao; Umemura, Takeji; Kawa, Shigeyuki

    2017-01-01

    Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis characterized by high serum IgG4 concentration and a variety of complicating extra-pancreatic lesions. AIP has the features of a complex disease that is caused by multifactorial genes. However, the genetic factors underlying AIP have not been elucidated conclusively. Association studies by the candidate-gene approach and genome-wide association studies (GWAS) have revealed several susceptibility genes for AIP, including HLA DRB1*04:05-DQB1*04:01, FCRL3, CTLA4, and KCNA3, albeit in small-scale analyses. Thus, GWAS of large sample sizes and multinational collaborative meta-analyses are needed to identify the precise genetic variants that are associated with AIP onset. Systems genetics approaches that integrate DNA sequencing, expression quantitative trait locus (eQTL) mapping, proteomics, and metabolomics will also be useful in clarifying the pathogenesis of AIP.

  11. Resistance to octreotide LAR in acromegalic patients with high SSTR2 expression: analysis of AIP expression.

    PubMed

    Kasuki, Leandro; Colli, Leandro M; Elias, Paula C L; Castro, Margaret de; Gadelha, Mônica R

    2012-11-01

    We present here the clinical and molecular data of two patients with acromegaly treated with octreotide LAR after non-curative surgery, and who presented different responses to therapy. Somatostatin receptor type 2 and 5 (SSTR2 and SSTR5), and aryl hydrocarbon receptor-interacting protein (AIP) expression levels were analyzed by qPCR. In both cases, high SSTR2 and low SSTR5 expression levels were detected; however, only one of the patients achieved disease control after octreotide LAR therapy. When we analyzed AIP expression levels of both cases, the patient whose disease was controlled after therapy exhibited AIP expression levels that were two times higher than the patient whose disease was still active. These two cases illustrate that, although the currently available somatostatin analogs bind preferentially to SSTR2, some patients are not responsive to therapy despite high expression of this receptor. This difference could be explained by differences in post-receptor signaling pathways, including the recently described involvement of AIP.

  12. Pathways to Career Success for Women: A Resource Guide to Colleges, Financial Aid, and Work.

    ERIC Educational Resources Information Center

    Powley, Sherry; Sabol, Laurie

    This book provides essays on career topics aimed at women and a directory of tools to help women get started or take their career to the next level. The essays topics are equal education and employment; role models, networks, and mentors for women; financial management; child care; introduction to financial aid; women's colleges and women's…

  13. Raising the Bar: An Examination of Career Pathways among Women Working in the Child Welfare System

    ERIC Educational Resources Information Center

    Williams, Vera L.

    2013-01-01

    In today's society, women who return back to school seeking an advancement within their career is a transition within the lives of women that occurs in various contexts, including the women's ages at the time of their transition, which can define both their expectations and opportunities along their life stages and career paths. In the past, women…

  14. Exploring Embedded Remediation for Community College Career Technical Education Pathways: Promising Practices

    ERIC Educational Resources Information Center

    Cooper, Donna Walters

    2014-01-01

    Public community colleges enroll nearly half of all undergraduate students in the United States and many of these students are enrolled in 1- and 2-year Career and Technical Education programs. Employers have indicated that colleges should place more emphasis on reading, writing, and critical thinking skills. Career Technical Education can address…

  15. Support from Teachers and Trainers in Vocational Education and Training: The Pathways to Career Aspirations and Further Career Development

    ERIC Educational Resources Information Center

    Hofmann, Claudia; Stalder, Barbara E.; Tschan, Franziska; Häfeli, Kurt

    2014-01-01

    Transition from school to work is a challenging period for young people with learning difficulties. In the dual vocational system of Switzerland, teachers at vocational educational and training (VET)-schools, as well as trainers at VET-companies, provide important support. We were interested in the different pathways from this support to…

  16. Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Beckers, Albert; Aaltonen, Lauri A; Daly, Adrian F; Karhu, Auli

    2013-04-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  17. Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene

    PubMed Central

    Aaltonen, Lauri A.; Daly, Adrian F.

    2013-01-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  18. AIP 50th anniversary: Physics vade mecum

    NASA Astrophysics Data System (ADS)

    Anderson, H. L.

    This compendium is intended to be of use to the wide spectrum of physicists associated with the AIP through its member societies. Twenty-two subjects broadly representative of physics as a whole are discussed. Each subeditor was charged to compile within 10 pages the most useful information, formulas, numerical data, definitions, and references most physicists would like to have at hand. The General Section is a compilation of the fundamental constants, the SI units and prefixes, conversion factors, magnitudes, basic mathematical and physics formulas, formulas useful in practical physics applications, and a list of physics data centers. The particular fields considered are: acoustics, astronomy and astrophysics, atomic collision properties, atomic spectroscopy, biological physics, cryogenics, crystallography, elementary particles, energy demand, energy supply, fluid dynamics, high polymer physics, medical physics, molecular spectroscopy and structure, nuclear physics, optics, plasma physics, rheology, solid state physics, surface physics, and thermophysics.

  19. Resources for History of Geophysics at AIP

    NASA Astrophysics Data System (ADS)

    Good, G. A.

    2012-12-01

    The history programs of the American Institute of Physics -- the Center for History of Physics and the Niels Bohr Library & Archives -- maintain a wide variety of research resources for the history of physics generally, and for the history of geophysics in particular. AIP has over 20,000 photographs online, nearly 1000 oral history interview transcripts, and much more. The International Catalog of Sources provides an online union catalog of manuscript collections held worldwide. An important collection of IUGG records is available onsite, as also is the recently accessioned collection of AGU papers. As the 2019 centenary of AGU approaches, these resources will be of interest to both AGU members and historians of science.;

  20. Molecular genetics of the aip gene in familial pituitary tumorigenesis.

    PubMed

    Tahir, Asil; Chahal, Harvinder S; Korbonits, Márta

    2010-01-01

    Pituitary adenomas usually occur as sporadic tumors, but familial cases are now increasingly identified. As opposed to multiple endocrine neoplasia type 1 and Carney complex, in familial isolated pituitary adenoma (FIPA) syndrome no other disease is associated with the familial occurrence of pituitary adenomas. It is an autosomal dominant disease with incomplete variable penetrance. Approximately 20% of patients with FIPA harbour germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene located on 11q13. Patients with AIP mutations have an overwhelming predominance of somatotroph and lactotroph adenomas, which often present in childhood or young adulthood. AIP, originally identified as a molecular co-chaperone of several nuclear receptors, is thought to act as a tumor suppressor gene; overexpression of wild-type, but not mutant AIP, reduces cell proliferation while knockdown of AIP stimulates it. AIP is shown to bind various proteins, including the aryl hydrocarbon receptor, Hsp90, phosphodiesterases, survivin, RET and the glucocorticoid receptor, but currently it is not clear which interaction has the leading role in pituitary tumorigenesis. This chapter summarizes the available clinical and molecular data regarding the role of AIP in the pituitary gland.

  1. Entrepreneurial Pathways in Higher Education: The Learning and Career-Making Experiences of Faculty Entrepreneurs

    ERIC Educational Resources Information Center

    Feldmann, Bridget D.

    2013-01-01

    While interest in and demand for academic entrepreneurship has gained prominence in recent years, there is minimal qualitative research on the learning experiences and career-making events that transform traditional faculty members into faculty entrepreneurs who are able to successfully apply their research knowledge toward endeavors that…

  2. Contextualising the Career Pathways of Women Principals in Hong Kong: A Critical Examination

    ERIC Educational Resources Information Center

    Chan, Anita Kit-wa; Ngai, George Siu-keung; Choi, Po-king

    2016-01-01

    The fields of gender and educational leadership have been enriched recently by analyses of national case studies from non-western contexts. By contextualising women's career development, these studies highlight the importance of including experiences other than those generated from Anglo-American-Australian contexts, thus broadening our knowledge…

  3. Stackable Credentials and Career/college Pathways in Culinary Arts at Kingsborough Community College, CUNY

    ERIC Educational Resources Information Center

    Audant, Anne Babette

    2016-01-01

    Discussions of workforce development emphasize stackable training, and assume linear advancement and alignment, through college and career paths. Stackable credentials have become a best practice for community colleges across the United States as they struggle to advance the college completion agenda and ensure that students graduate with the…

  4. Understanding the conditions that encourage the persistence of women in science, mathematics, and engineering career pathways

    NASA Astrophysics Data System (ADS)

    Kondrick, Linda C.

    The purpose of this study was to determine which factors encourage the persistence of women in the pursuit of Science, Math, and Engineering (SME) careers. Surveys with 36 parallel pairs of theory and history questions regarding the importance and the aptness of variables identified in the literature were completed by 205 SME career women. The variables covered three educational levels: High School, Undergraduate and Graduate. Results reveal which variables fit the experiences of these women and were also believed by them to be important to women in the pursuit of an SME career goal. False Negatives, women who according to the SME literature should not have persisted but did, were identified. Their existence, together with the false positives identified in the SME literature, is evidence, according to Confirmation/Disconfirmation Theory, that important variables in SME persistence are yet to be discovered. Follow-up telephone interviews with nineteen respondents identified important affective variables. Love of math or science was in itself a powerful motivator. Respondents made suggestions for intervention programs that may help to develop that abiding interest. Mentors, role models, and social support networks were identified as important in building the confidence and sustaining the focus needed to cope with the rigorous curriculum and negative sex-bias encountered in SME programs. The qualitative and quantitative results were synthesized in a Causal Event Flow Network, a cognitive map of the longitudinal effects of both positive and negative push/pull vectors operating on women in pursuit of an SME career goal.

  5. A Study of "Career Pathways" Policy with Implications for School Leaders

    ERIC Educational Resources Information Center

    Ormsmith, Michael I.; Mansfield, Katherine Cumings

    2014-01-01

    This explanatory mixed-methods study began with a quantitative survey to investigate counselor beliefs and implementation behaviors related to providing college and career planning services to high school students. Survey results informed the development and implementation of interview protocol designed to provide deeper insight into counselors'…

  6. Pathways to Career Success for Minorities: A Resource Guide to Colleges, Financial Aid, and Work.

    ERIC Educational Resources Information Center

    Powley, Sherry; Schaffert, Tim

    This book contains 10 essays and a directory of financial aid, organizations, and additional information that minority students and employees can use to find sources of funding for further education and career advancement. The 10 essays cover the following topics: (1) general minority work issues; (2) introduction to financial aid; (3) minorities…

  7. AIP history center seeks old books and photographs

    NASA Astrophysics Data System (ADS)

    AGU members can give essential help to an effort to gather materials that are important for education and public understanding of geophysics. Now that AGU is a Member Society of the American Institute of Physics (AIP), the AIP Center for History of Physics is striving to enlarge its collections of materials on the history of geophysics. They are appealing to AGU members to help AIP locate and acquire materials, such as classic textbooks and old snapshots, that will be invaluable to future historians and educators.

  8. University of Washington's eScience Institute Promotes New Training and Career Pathways in Data Science

    NASA Astrophysics Data System (ADS)

    Stone, S.; Parker, M. S.; Howe, B.; Lazowska, E.

    2015-12-01

    Rapid advances in technology are transforming nearly every field from "data-poor" to "data-rich." The ability to extract knowledge from this abundance of data is the cornerstone of 21st century discovery. At the University of Washington eScience Institute, our mission is to engage researchers across disciplines in developing and applying advanced computational methods and tools to real world problems in data-intensive discovery. Our research team consists of individuals with diverse backgrounds in domain sciences such as astronomy, oceanography and geology, with complementary expertise in advanced statistical and computational techniques such as data management, visualization, and machine learning. Two key elements are necessary to foster careers in data science: individuals with cross-disciplinary training in both method and domain sciences, and career paths emphasizing alternative metrics for advancement. We see persistent and deep-rooted challenges for the career paths of people whose skills, activities and work patterns don't fit neatly into the traditional roles and success metrics of academia. To address these challenges the eScience Institute has developed training programs and established new career opportunities for data-intensive research in academia. Our graduate students and post-docs have mentors in both a methodology and an application field. They also participate in coursework and tutorials to advance technical skill and foster community. Professional Data Scientist positions were created to support research independence while encouraging the development and adoption of domain-specific tools and techniques. The eScience Institute also supports the appointment of faculty who are innovators in developing and applying data science methodologies to advance their field of discovery. Our ultimate goal is to create a supportive environment for data science in academia and to establish global recognition for data-intensive discovery across all fields.

  9. Beyond One-Size-Fits-All College Dreams: Alternative Pathways to Desirable Careers

    ERIC Educational Resources Information Center

    Rosenbaum, James E.; Stephan, Jennifer L.; Rosenbaum, Janet E.

    2010-01-01

    The vast majority of high school students plan to attend college--and believe that a bachelor's degree all but guarantees them a high-paying job. What many of them don't know is that those who are not well prepared are not likely to graduate. They also don't realize that plenty of career-focused certificates and associate's degrees lead to…

  10. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.

    PubMed

    Zhang, Jiqin; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang

    2015-05-01

    AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC). While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein). Human genome-wide association study (GWAS) has identified DAB2IP gene variants conferring susceptibility to cardiovascular diseases. Consistently, a global or vascular EC-specific deletion of DAB2IP in mice strongly enhances inflammatory responses and exacerbates atherosclerosis and graft arteriosclerosis progression in mouse models. Mechanisms for AIP1 function and regulation associated with human cardiovascular diseases need further investigations.

  11. Aryl Hydrocarbon Receptor-Interacting Protein (AIP) N-Terminus Gene Mutations Identified in Pituitary Adenoma Patients Alter Protein Stability and Function.

    PubMed

    Formosa, Robert; Vassallo, Josanne

    2017-03-02

    Mutations spanning the entire aryl hydrocarbon receptor-interacting protein (AIP) gene have been found in isolated familial cases of pituitary adenomas (PA). Missense mutations located in the N-terminus of the gene have been identified in several patients. However, the functional significance of these mutations remains a matter of controversy. In most studies, the N-terminus of AIP has been shown to regulate protein stability and subcellular localization of the AIP-AHR-HSP90 complex but not to be involved in protein-protein interactions. Other studies found that the N-terminal domain interacts directly with other proteins. The aim of this study was to analyze whether specific N-terminus AIP mutations identified in PA patients would be functionally different from wild-type (WT) AIP. In vitro analyses were used to assess the role of known N-terminus variants, a locally identified mutant, R9Q, and three other commonly genotyped N-terminus mutations R16H, V49M and K103R are found in PA patients. Given the functional effect of WT AIP on cAMP signalling alterations caused by N-terminus mutants on this pathway were also analyzed in GH3 cells. Results indicate that N-terminus mutations lead to de-regulation of the effect of WT AIP on cAMP signalling and increased cAMP thresholds in GH3 cells resulting in increased growth hormone (GH) secretion. Cycloheximide chase analysis identified a variation in protein degradation patterns between WT and N-terminus variants. Therefore, both functional and structural studies reveal that N-terminus mutations in the AIP gene alter protein behaviour significantly and hence can truly be pathogenic in nature.

  12. State Strategies for Sustaining and Scaling Grades 9-14 Career Pathways: Toward a Policy Set for Pathways to Prosperity

    ERIC Educational Resources Information Center

    Cahill, Charlotte; Hoffman, Nancy; Loyd, Amy; Vargas, Joel

    2014-01-01

    This brief begins with a discussion of the composition of state leadership teams and organizing structures for supporting a Pathways to Prosperity Network initiative, and then describes effective strategies currently at play in the network states for jumpstarting work in the regions. It goes on to review state policies that support 9-14…

  13. Building a Linked Learning Pathway: A Guide for Transforming High Schools for College and Career Success

    ERIC Educational Resources Information Center

    Atterbury, Rob

    2014-01-01

    This guide provides an overview of a more robust online guide and toolkit available through ConnectEd Studios. It supplies a glimpse of the sequence of steps involved in creating a new Linked Learning pathway. This publication can help coaches, district leadership, and pathway teams gain an understanding of the overall process of designing and…

  14. Opening Pathways for Underrepresented High School Students to Biomedical Research Careers: The Emory University RISE Program

    PubMed Central

    Rohrbaugh, Margaret C.; Corces, Victor G.

    2011-01-01

    Increasing the college graduation rates of underrepresented minority students in science disciplines is essential to attain a diverse workforce for the 21st century. The Research Internship and Science Education (RISE) program attempts to motivate and prepare students from the Atlanta Public School system, where underrepresented minority (URM) students comprise a majority of the population, for biomedical science careers by offering the opportunity to participate in an original research project. Students work in a research laboratory from the summer of their sophomore year until graduation, mentored by undergraduate and graduate students and postdoctoral fellows (postdocs). In addition, they receive instruction in college-level biology, scholastic assessment test (SAT) preparation classes, and help with the college application process. During the last 4 yr, RISE students have succeeded in the identification and characterization of a series of proteins involved in the regulation of nuclear organization and transcription. All but 1 of 39 RISE students have continued on to 4-year college undergraduate studies and 61% of those students are currently enrolled in science-related majors. These results suggest that the use of research-based experiences at the high school level may contribute to the increased recruitment of underrepresented students into science-related careers. PMID:21926301

  15. Opening pathways for underrepresented high school students to biomedical research careers: the Emory University RISE program.

    PubMed

    Rohrbaugh, Margaret C; Corces, Victor G

    2011-12-01

    Increasing the college graduation rates of underrepresented minority students in science disciplines is essential to attain a diverse workforce for the 21st century. The Research Internship and Science Education (RISE) program attempts to motivate and prepare students from the Atlanta Public School system, where underrepresented minority (URM) students comprise a majority of the population, for biomedical science careers by offering the opportunity to participate in an original research project. Students work in a research laboratory from the summer of their sophomore year until graduation, mentored by undergraduate and graduate students and postdoctoral fellows (postdocs). In addition, they receive instruction in college-level biology, scholastic assessment test (SAT) preparation classes, and help with the college application process. During the last 4 yr, RISE students have succeeded in the identification and characterization of a series of proteins involved in the regulation of nuclear organization and transcription. All but 1 of 39 RISE students have continued on to 4-year college undergraduate studies and 61% of those students are currently enrolled in science-related majors. These results suggest that the use of research-based experiences at the high school level may contribute to the increased recruitment of underrepresented students into science-related careers.

  16. Career Academy Course Sequences.

    ERIC Educational Resources Information Center

    Markham, Thom; Lenz, Robert

    This career academy course sequence guide is designed to give teachers a quick overview of the course sequences of well-known career academy and career pathway programs from across the country. The guide presents a variety of sample course sequences for the following academy themes: (1) arts and communication; (2) business and finance; (3)…

  17. Cortical connections of the macaque anterior intraparietal (AIP) area.

    PubMed

    Borra, Elena; Belmalih, Abdelouahed; Calzavara, Roberta; Gerbella, Marzio; Murata, Akira; Rozzi, Stefano; Luppino, Giuseppe

    2008-05-01

    We traced the cortical connections of the anterior intraparietal (AIP) area, which is known to play a crucial role in visuomotor transformations for grasping. AIP displayed major connections with 1) areas of the inferior parietal lobule convexity, the rostral part of the lateral intraparietal area and the SII region; 2) ventral visual stream areas of the lower bank of the superior temporal sulcus and the middle temporal gyrus; and 3) the premotor area F5 and prefrontal areas 46 and 12. Additional connections were observed with the caudal intraparietal area and the ventral part of the frontal eye field. This study suggests that visuomotor transformations for object-oriented actions, processed in AIP, rely not only on dorsal visual stream information related to the object's physical properties but also on ventral visual stream information related to object identity. The identification of direct anatomical connections with the inferotemporal cortex suggests that AIP also has a unique role in linking the parietofrontal network of areas involved in sensorimotor transformations for grasping with areas involved in object recognition. Thus, AIP could represent a crucial node in a cortical circuit in which hand-related sensory and motor signals gain access to representations of object identity for tactile object recognition.

  18. Undergraduate Research as a Primary Pathway to STEM Careers: Perspectives from the Council on Undergraduate Research

    NASA Astrophysics Data System (ADS)

    Manley, P. L.; Ambos, E. L.

    2012-12-01

    Undergraduate research (UR) is one of the most authentic and effective ways to promote student learning, and is a high-impact educational practice that can lead to measurable gains in student retention and graduation rates, as well as career aspirations. In recent years, UR has expanded from intensive summer one-on-one faculty-student mentored experiences to application in a variety of educational settings, including large lower division courses. The Council on Undergraduate Research (CUR), founded in 1978, is a national organization of individual (8000) and institutional members (650) within a divisional structure that includes geosciences, as well as 10 other thematic areas. CUR's main mission is to support and promote high-quality undergraduate student-faculty collaborative research and scholarship that develops learning through research. CUR fulfills this mission through extensive publication offerings, faculty and student-directed professional development events, and outreach and advocacy activities that share successful models and strategies for establishing, institutionalizing, and sustaining undergraduate research programs. Over the last decade, CUR has worked with hundreds of academic institutions, including two-year colleges, to develop practices to build undergraduate research into campus cultures and operations. As documented in CUR publications such as Characteristics of Excellence in Undergraduate Research (COEUR), strategies institutions may adopt to enhance and sustain UR often include: (1) the establishment of a central UR campus office, (2) extensive student and faculty participation in campus-based, as well as regional UR celebration events, (3) development of a consistent practice of assessment of UR's impact on student success, and, (4) establishment of clear policies for recognizing and rewarding faculty engagement in UR, particularly with respect to mentorship and publication with student scholars. Three areas of current focus within the

  19. Pathways to Teaching: African American Male Teens Explore Teaching as a Career

    ERIC Educational Resources Information Center

    Bianco, Margarita; Leech, Nancy L.; Mitchell, Kara

    2011-01-01

    The need for African American male teachers is clear; however their pathway to teaching is in disrepair. This article shares research findings and a description of a pre-collegiate course designed to encourage high school students of color, including African American males, to explore teaching. More specifically, drawing from survey and interview…

  20. On AIPS++, a new astronomical information processing system

    NASA Technical Reports Server (NTRS)

    Croes, G. A.

    1992-01-01

    The AIPS system that has served the needs of the radio astronomical community remarkably well during the last 15 years is showing signs of age and is being replaced by a more modern system, AIPS++. As the name implies, AIPS++ will be developed in a object oriented fashion and will use C++ as its main programming language. The work is being done by a consortium of seven organizations, with coordinated activities worldwide. After a review of the history of the project to this date from management, astronomical and technical viewpoints, and the current state of the project, the paper concentrates on the tradeoffs implied by the choice of implementation style and the lessons we have learned, good and bad.

  1. Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP.

    PubMed

    Pedersen, Linda Margareth; Lien, Guro Flor; Bollerud, Ingunn; Gjerstad, Johannes

    2005-04-11

    Neuronal events leading to development of long-term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying central hyperalgesia. Here, we examine whether induction of LTP in nociceptive dorsal horn neurons at depths of 80-500 microm from the cord surface can be affected by spinal application of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitor AIP. Extracellular recordings from single neurons in intact urethane anesthetized Sprague-Dawley rats were performed, and the neuronal A-fiber and C-fiber responses after sciatic nerve test pulses were defined according to latencies. A clear LTP of the nociceptive transmission following sciatic nerve high-frequency stimulation (HFS) was observed in single neurons in laminae I-IV of the dorsal horn. The increase in the C-fiber response after HFS was blocked in the presence of 2.0 mM AIP (P < 0.05 HFS group versus AIP + HFS group 2 h after conditioning). However, the C-fiber response was not affected by 2.0 mM AIP alone or by vehicle. Thus, our data show that the neuronal process leading to the induction of LTP in the dorsal horn induced by HFS is clearly inhibited by the specific CaMKII inhibitor AIP. It is concluded that CaMKII may be important for the induction of LTP in single nociceptive dorsal horn neurons.

  2. Career pathways for temporary workers: exploring heterogeneous mobility dynamics with sequence analysis.

    PubMed

    Fuller, Sylvia; Stecy-Hildebrandt, Natasha

    2015-03-01

    Because temporary jobs are time-delimited, their implications for workers' economic security depend not only on their current characteristics, but also their place in longer-term patterns of mobility. Past research has typically asked whether temporary jobs are a bridge to better employment or trap workers in ongoing insecurity, investigating this question by analyzing single transitions. We demonstrate that this approach is ill-suited to assessing the often more complex and turbulent employment patterns characteristic of temporary workers. Our analysis instead employs sequence methods to compare a representative sample of temporary workers' month-by-month mobility patterns through 8 potential (non)employment states over five years. We derive a typology of trajectories and describe their relative precariousness in relation to employment stability and wage and earnings levels and growth. While some of the pathways correspond quite closely to frameworks used by past research, others reveal new and important distinctions. Multinomial logit models reveal job, employer, and worker characteristics associated with different pathways. Age, gender, and type of temporary work stand out as important factors shaping subsequent mobility patterns.

  3. Work, Family, and the Faculty Career. New Pathways: Faculty Career and Employment for the 21st Century Working Paper Series, Inquiry #8.

    ERIC Educational Resources Information Center

    Gappa, Judith M.; MacDermid, Shelley M.

    This paper, one in a series about the priorities of the professoriate, examines work-family issues as they affect faculty recruitment, retention, and productivity. Following a brief discussion of changing work-force demographics, the first part of the paper examines the structure of an academic career, focusing particularly on junior faculty and…

  4. Career Pathways: Does Remaining Close to the Classroom Matter for Early Career Teachers? A Study of Practice in New Zealand and the USA

    ERIC Educational Resources Information Center

    Lovett, Susan; Cameron, Marie

    2011-01-01

    Retaining early career teachers and enticing promising teachers to become teacher leaders are issues of international interest not only because large numbers of teachers will retire from the profession over the next five to 10 years but also because the strongest teachers are the teachers most likely to leave the profession during their early…

  5. 76 FR 44978 - Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ...-0786] Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds AGENCY... Program (AIP) must notify, in writing, the designated representative in the appropriate FAA Regional or... grants to the following year. In such cases, the FAA converts the current-year funds to AIP...

  6. Pathways from parental stimulation of children's curiosity to high school science course accomplishments and science career interest and skill

    NASA Astrophysics Data System (ADS)

    Eskeles Gottfried, Adele; Johnson Preston, Kathleen Suzanne; Gottfried, Allen W.; Oliver, Pamella H.; Delany, Danielle E.; Ibrahim, Sirena M.

    2016-08-01

    Curiosity is fundamental to scientific inquiry and pursuance. Parents are important in encouraging children's involvement in science. This longitudinal study examined pathways from parental stimulation of children's curiosity per se to their science acquisition (SA). A latent variable of SA was indicated by the inter-related variables of high school science course accomplishments, career interest, and skill. A conceptual model investigated parental stimulation of children's curiosity as related to SA via science intrinsic motivation and science achievement. The Fullerton Longitudinal Study provided data spanning school entry through high school (N = 118). Parental stimulation of curiosity at age 8 years comprised exposing children to new experiences, promoting curiosity, encouraging asking questions, and taking children to a museum. Intrinsic motivation was measured at ages 9, 10, and 13 years, and achievement at ages 9, 10, and 11 years. Structural equation modelling was used for analyses. Controlling for socio-economic status, parental stimulation of curiosity bore positive and significant relations to science intrinsic motivation and achievement, which in turn related to SA. Gender neither related to stimulation of curiosity nor contributed to the model. Findings highlight the importance of parental stimulation of children's curiosity in facilitating trajectories into science, and relevance to science education is discussed.

  7. Some Comments on Marketing AIP Information Products and Services.

    ERIC Educational Resources Information Center

    King, Donald W.; Brown, A. M.

    This study was addressed to marketing considerations for the American Institute of Physics (AIP) information products and services. The general system and its operation in a marketing environment, including promotion, channels of distribution and pricing are covered. Particular emphasis is placed on the cost/demand/price relationship for four…

  8. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease

    PubMed Central

    Niroumand, Shabnam; Khajedaluee, Mohammad; Khadem-Rezaiyan, Majid; Abrishami, Maryam; Juya, Mohammadreza; Khodaee, Gholamhasan; Dadgarmoghaddam, Maliheh

    2015-01-01

    Background: Cardiovascular disease (CVD) is the cause of one third of deaths worldwide and this will progress because of increasing CVD's risk factors. The most basic task of dealing with the epidemic of CVD is primary prevention of risk factors. As Atherogenic Index of Plasma (AIP) is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the correlation between AIP and other important factors. Methods: This cross-sectional study was a part of national non-communicable risk factors surveillance system data that has been established since 2004 in Iran. This was done on 1000 people between 2008 and 2010. The study was approved by Ethics Committee of Mashhad University of Medical Science. Chi square, Mann-Whitney U, correlation tests were used in this study. Statistical analysis was performed using SPSS version 11. In all calculations, p <0.05 was considered as statistically significant level. Results: The study population consisted of 500 men and 500 women with mean±SD age 41.9±14.2 years. According to the AIP category, 9.8% (98) were in low risk group, 12.7% (127) were in intermediate risk and 77.5% (775) were in increased risk of CVD. AIP was significantly correlated with waist circumference (r=0.35, p<0.001), BMI (r=0.33, p<0.001) and physical activity (r=-0.09, p<0.01). Conclusion: AIP can be used as a regular monitoring index of CVD in every day practice, especially in persons with other cardiovascular risk factors. PMID:26793631

  9. Pathways to Achievement: Career and Educational Aspirations and Expectations of Latina/o Immigrant Parents and Early Adolescents

    ERIC Educational Resources Information Center

    Chavira, Gabriela; Cooper, Catherine R.; Vasquez-Salgado, Yolanda

    2016-01-01

    Drawing on sociocultural and related theories, 4 questions examined career and educational aspirations and expectations among 24 immigrant Latina/o early adolescents and their parents as predictors of students' grades. First, adolescents' career aspirations and expectations were correlated, and both parents and adolescents held educational…

  10. Second-career teachers

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Last month we saw that the age distribution for high school physics teachers skewed older than that of all teachers. We also noted that, even though they are older, at least three-fourths of the high school physics teachers indicated that they planned to teach high school for at least six more years. The figure shows the age and years of teaching experience for high school physics teachers. We see that almost 12% of the teachers who are 50 years old or older have five years or fewer of teaching experience. Thus, these are likely second-career teachers. The typical age range for second-career teachers is 33 to 59. However, the younger second-career teachers are more difficult to isolate because the average duration of the previous career is one and one-half to three years. In the December issue, we will look at teaching activities physics teachers use in the classroom, Susan White is Research Manager in the Statistical Research Center at the American Institute of Physics; she directs the Nationwide Survey of High School Physics Teachers. If you have any questions, please contact Susan at swhite@aip.org.

  11. Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

    PubMed

    Scudder, C J; Niessen, S J; Catchpole, B; Fowkes, R C; Church, D B; Forcada, Y

    2017-04-01

    Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human acromegalic families with AIP mutations. The aim of this study was to sequence the feline AIP gene, identify sequence variants and compare the AIP gene sequence between feline acromegalic and control cats, and in acromegalic siblings. The feline AIP gene was amplified through PCR using whole blood genomic DNA from 10 acromegalic and 10 control cats, and 3 sibling pairs affected by acromegaly. PCR products were sequenced and compared with the published predicted feline AIP gene. A single nonsynonymous SNP was identified in exon 1 (AIP:c.9T > G) of two acromegalic cats and none of the control cats, as well as both members of one sibling pair. The region of this SNP is considered essential for the interaction of the AIP protein with its receptor. This sequence variant has not previously been reported in humans. Two additional synonymous sequence variants were identified (AIP:c.481C > T and AIP:c.826C > T). This is the first molecular study to investigate a potential genetic cause of feline acromegaly and identified a nonsynonymous AIP single nucleotide polymorphism in 20% of the acromegalic cat population evaluated, as well as in one of the sibling pairs evaluated.

  12. Industrial Physics Careers: A Large Company Perspective

    NASA Astrophysics Data System (ADS)

    Zollner, Stefan

    2009-03-01

    Statistical data from the American Institute of Physics and the National Science Foundation show that only about a third of physics graduates get permanent jobs in academia. A few work in government labs and hospitals. The majority of physics Ph.D.s, however, find employment in the private sector (industry). This trend has been increasing, i.e., recent Ph.D.s are even more likely to start careers in industry. Industrial physicists work in small, medium or large companies in a broad range of fields, including aerospace, semiconductors, automotive, energy, information technology, contract research, medical, chemical, optics, etc. They are also represented in fields outside of physics, such as finance. Even the ``inventor'' of the Powerball lottery game is a Ph.D. physicist. In my talk, I will describe pathways to success for an industrial physicist, from the perspective of employment in three different large corporations. Based on the NIST Baldridge criteria of Performance Excellence, I will discuss how to achieve and measure organizational success through focus on products and customers. Individual performance is linked to the goals of the organization. Performance has two components: Goals and behaviors. Both are key to success as an individual contributor or manager.[4pt] References: [0pt] http://www.aip.org/statistics/trends/emptrends.html [0pt] http://www.aps.org/about/governance/committees/commemb/index.cfm [0pt] http://www.quality.nist.gov/

  13. The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.

    PubMed

    Le Clorennec, Christophe; Lazrek, Yassamine; Dubreuil, Olivier; Larbouret, Christel; Poul, Marie-Alix; Mondon, Philippe; Melino, Gerry; Pèlegrin, André; Chardès, Thierry

    2016-06-14

    We characterized the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway, leading to cell cycle arrest and apoptosis in vitro and regression of pancreatic and breast cancer in vivo. We found that 9F7-F11 induces rapid HER3 down-regulation. Specifically, 9F7-F11-induced HER3 ubiquitination and degradation in pancreatic, breast and prostate cancer cell lines was driven mainly by the itchy E3 ubiquitin ligase (ITCH/AIP4). Overexpression of the ITCH/AIP4 inhibitor N4BP1 or small-interfering RNA-mediated knockdown of ITCH/AIP4 inhibited HER3 ubiquitination/degradation and PI3K/AKT signaling blockade induced by 9F7-F11. Moreover, 9F7-F11-mediated JNK1/2 phosphorylation led to ITCH/AIP4 activation and recruitment to HER3 for receptor ubiquitination and degradation. ITCH/AIP4 activity was activated by the deubiquitinases USP8 and USP9X, as demonstrated by RNA interference. Taken together, our results suggest that 9F7-F11-induced HER3 ubiquitination and degradation in cancer cells mainly occurs through JNK1/2-dependent ITCH/AIP4 activation.

  14. An AIPS++ Commissioning Tool for the Green Bank Telescope

    NASA Astrophysics Data System (ADS)

    Braatz, J.; McMullin, J.; Garwood, R.; Maddalena, R.; Norrod, R.

    1999-12-01

    The Green Bank Telescope (GBT) is a 100-m diameter antenna with an unblocked aperture and an active surface. It is designed to observe at frequencies from 300 MHz to 100 GHz. Construction of the telescope is now in the final phase - installation of the surface panels - and will be completed in early 2000. The electronics systems for the telescope have been under development and testing in a "Mock-up" which includes the receivers, LO systems, analog filters, and the backends. Upon completion of construction, the telescope will undergo a series of commissioning procedures to prepare for general astronomical observing. We will illustrate the software tools being developed in support of the engineering tests and commissioning requirements of the GBT. These requirements include analysis of holography data, which will be used to measure the initial surface accuracy of the dish. This software is being developed in the AIPS++ programming environment using Glish, a powerful scripting language adopted by the AIPS++ system.

  15. Familial pituitary adenomas - who should be tested for AIP mutations?

    PubMed

    Korbonits, Márta; Storr, Helen; Kumar, Ajith V

    2012-09-01

    Familial Isolated Pituitary Adenomas (FIPA), an autosomal dominant disease with low penetrance is being increasingly recognized. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. Patients with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are characterized by young-onset somatotroph or lactotroph macroadenomas, while in the other, larger group of FIPA patients with typically adult-onset disease and more varied adenoma types, no causative gene(s) has been identified. Young-onset macroadenoma patients can also be identified with germline AIP mutation without an apparent family history. Further data and longer follow-up are necessary to establish formal guidelines, but the current data suggest genetic screening of the AIP gene in patients with a pituitary adenoma and no other associated features who have (i) a family history of pituitary adenoma, (ii) childhood-onset pituitary adenoma or (iii) a pituitary somatotroph or lactotroph macroadenoma diagnosed before the age of 30 years.

  16. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

    PubMed

    Hassan, Wail M; Merin, David A; Fonte, Virginia; Link, Christopher D

    2009-08-01

    Multiple neurodegenerative diseases are causally linked to aggregation-prone proteins. Cellular mechanisms involving protein turnover may be key defense mechanisms against aggregating protein disorders. We have used a transgenic Caenorhabditis elegans Alzheimer's disease model to identify cellular responses to proteotoxicity resulting from expression of the human beta amyloid peptide (Abeta). We show up-regulation of aip-1 in Abeta-expressing animals. Mammalian homologues of AIP-1 have been shown to associate with, and regulate the function of, the 26S proteasome, leading us to hypothesize that induction of AIP-1 may be a protective cellular response directed toward modulating proteasomal function in response to toxic protein aggregation. Using our transgenic model, we show that overexpression of AIP-1 protected against, while RNAi knockdown of AIP-1 exacerbated, Abeta toxicity. AIP-1 overexpression also reduced accumulation of Abeta in this model, which is consistent with AIP-1 enhancing protein degradation. Transgenic expression of one of the two human aip-1 homologues (AIRAPL), but not the other (AIRAP), suppressed Abeta toxicity in C. elegans, which advocates the biological relevance of the data to human biology. Interestingly, AIRAPL and AIP-1 contain a predicted farnesylation site, which is absent from AIRAP. This farnesylation site was shown by others to be essential for an AIP-1 prolongevity function. Consistent with this, we show that an AIP-1 mutant lacking the predicted farnesylation site failed to protect against Abeta toxicity. Our results implicate AIP-1 in the regulation of protein turnover and protection against Abeta toxicity and point at AIRAPL as the functional mammalian homologue of AIP-1.

  17. Developing POS via a Statewide Career-Focused Reform Policy

    ERIC Educational Resources Information Center

    Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Stringfield, Sam; Stipanovic, Natalie; Sharp, Julia L.; Drew, Sam

    2012-01-01

    Career-focused education offered through programs of study (POS), career pathways, and career and technical education (CTE) can provide students with opportunities to engage in career exploration and development, to establish career goals, to increase academic knowledge and skills, to test career preferences in applied settings, and to make links…

  18. Motivational Pathways to STEM Career Choices: Using Expectancy-Value Perspective to Understand Individual and Gender Differences in STEM Fields

    PubMed Central

    Wang, Ming-Te; Degol, Jessica

    2013-01-01

    The United States has made a significant effort and investment in STEM education, yet the size and the composition of the STEM workforce continues to fail to meet demand. It is thus important to understand the barriers and factors that influence individual educational and career choices. In this article, we conduct a literature review of the current knowledge surrounding individual and gender differences in STEM educational and career choices, using expectancy-value theory as a guiding framework. The overarching goal of this paper is to provide both a well-defined theoretical framework and complementary empirical evidence for linking specific sociocultural, contextual, biological, and psychological factors to individual and gender differences in STEM interests and choices. Knowledge gained through this review will eventually guide future research and interventions designed to enhance individual motivation and capacity to pursue STEM careers, particularly for females who are interested in STEM but may be constrained by misinformation or stereotypes. PMID:24298199

  19. Recruiting Teachers to High-Need Schools: A Career Pathway that Builds on California's Afterschool Infrastructure. Afterschool Policy Brief

    ERIC Educational Resources Information Center

    Children Now, 2010

    2010-01-01

    Effective teachers are the most important component in high-quality education systems. Teachers are on the front line of education every day, carrying the responsibility for ensuring students are college- and career-ready upon graduation. As such, teachers also play a pivotal role in California's economic engine and prosperity. The state's current…

  20. An analysis of six cases of acute intermittent porphyria (AIP)

    PubMed Central

    Ghosh, Soumitra; Chaudhury, Pranit KR.; Goswami, Hiranya K.

    2006-01-01

    This analysis describes the diagnosis and psychiatric treatment modalities of 6 patients (5 women, 1 man; mean age 28.5 years) of acute intermittent porphyria (AIP), who presented to the Psychiatry OPD over a period of one year. The mean number of episodes was 2.83. Premorbid personality traits, clinical presentation, urine colour and urinary porphobilinogen titre were recorded. Among the 6 patients, 4 had abdominal pain, 5 had autonomic instability, all 6 had mental symptoms, 3 had depression, 2 came in delirium, and 3 had an episode of seizure. PMID:20844651

  1. Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

    PubMed

    Lecoq, Anne-Lise; Zizzari, Philippe; Hage, Mirella; Decourtye, Lyvianne; Adam, Clovis; Viengchareun, Say; Veldhuis, Johannes D; Geoffroy, Valérie; Lombès, Marc; Tolle, Virginie; Guillou, Anne; Karhu, Auli; Kappeler, Laurent; Chanson, Philippe; Kamenický, Peter

    2016-10-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip(+/-)) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of Aip(+/-) mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12 months of age. As the early stages of pituitary tumorigenesis are controversial, we also studied the pituitary histology and somatotroph cell proliferation in these mice. Aip(+/-) mice did not develop gigantism but exhibited a leaner phenotype than wild-type mice. Analysis of GH pulsatility by deconvolution in 12-month-old Aip(+/-) mice showed a mild increase in total GH secretion, a conserved GH pulsatility pattern, but a normal IGF1 concentration. No pituitary adenomas were detected up to 12 months of age. An increased ex vivo response to GHRH of pituitary explants from 3-month-old Aip(+/-) mice, together with areas of enlarged acini identified on reticulin staining in the pituitary of some Aip(+/-) mice, was suggestive of somatotroph hyperplasia. Global heterozygous Aip deficiency in mice is accompanied by subtle increase in GH secretion, which does not result in gigantism. The absence of pituitary adenomas in 12-month-old Aip(+/-) mice in our experimental conditions demonstrates the important phenotypic variability of this congenic mouse model.

  2. AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.

    PubMed

    Tuominen, I; Heliövaara, E; Raitila, A; Rautiainen, M-R; Mehine, M; Katainen, R; Donner, I; Aittomäki, V; Lehtonen, H J; Ahlsten, M; Kivipelto, L; Schalin-Jäntti, C; Arola, J; Hautaniemi, S; Karhu, A

    2015-02-26

    The aryl hydrocarbon receptor interacting protein (AIP) is a tumor-suppressor gene underlying the pituitary adenoma predisposition. Thus far, the exact molecular mechanisms by which inactivated AIP exerts its tumor-promoting action have been unclear. To better understand the role of AIP in pituitary tumorigenesis, we performed gene expression microarray analysis to examine changes between Aip wild-type and knockout mouse embryonic fibroblast (MEF) cell lines. Transcriptional analyses implied that Aip deficiency causes a dysfunction in cyclic adenosine monophosphate (cAMP) signaling, as well as impairments in signaling cascades associated with developmental and immune-inflammatory responses. In vitro experiments showed that AIP deficiency increases intracellular cAMP concentrations in both MEF and murine pituitary adenoma cell lines. Based on knockdown of various G protein α subunits, we concluded that AIP deficiency leads to elevated cAMP concentrations through defective Gαi-2 and Gαi-3 proteins that normally inhibit cAMP synthesis. Furthermore, immunostaining of Gαi-2 revealed that AIP deficiency is associated with a clear reduction in Gαi-2 protein expression levels in human and mouse growth hormone (GH)-secreting pituitary adenomas, thus indicating defective Gαi signaling in these tumors. By contrast, all prolactin-secreting tumors showed prominent Gαi-2 protein levels, irrespective of Aip mutation status. We additionally observed reduced expression of phosphorylated extracellular signal-regulated kinases 1/2 and cAMP response element-binding protein levels in mouse and human AIP-deficient somatotropinomas. This study implies for the first time that a failure to inhibit cAMP synthesis through dysfunctional Gαi signaling underlies the development of GH-secreting pituitary adenomas in AIP mutation carriers.

  3. Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations.

    PubMed

    Jaffrain-Rea, Marie-Lise; Rotondi, Sandra; Turchi, Annarita; Occhi, Gianluca; Barlier, Anne; Peverelli, Erika; Rostomyan, Lilya; Defilles, Céline; Angelini, Mariolina; Oliva, Maria-Antonietta; Ceccato, Filippo; Maiorani, Orlando; Daly, Adrian F; Esposito, Vincenzo; Buttarelli, Francesca; Figarella-Branger, Dominique; Giangaspero, Felice; Spada, Anna; Scaroni, Carla; Alesse, Edoardo; Beckers, Albert

    2013-10-01

    Germline aryl hydrocarbon receptor interacting protein (AIP) gene mutations confer a predisposition to pituitary adenoma (PA), predominantly GH-secreting (GH-PA). As recent data suggest a role for AIP in the pathogenesis of sporadic GH-PA and their response to somatostatin analogues (SSA), the expression of AIP and its partner, aryl hydrocarbon receptor (AHR), was determined by semiquantitative immunohistochemistry scoring in 62 sporadic GH-PA (37 treated with SSA preoperatively). The influence of Gsp status was studied in a subset of tumours (n=39, 14 Gsp(+)) and six GH-PA were available for primary cultures. AIP and AHR were detected in most cases, with a positive correlation between AIP and cytoplasmic AHR (P=0.012). Low AIP expression was significantly more frequent in untreated vs SSA-treated tumours (44.0 vs 20.5%, P=0.016). AHR expression or localisation did not differ between the two groups. Similarly, in vitro octreotide induced a median twofold increase in AIP expression (range 1.2-13.9, P=0.027) in GH-PA. In SSA-treated tumours, the AIP score was significantly higher in the presence of preoperative IGF1 decrease or tumour shrinkage (P=0.008 and P=0.014 respectively). In untreated tumours, low AIP expression was significantly associated with invasiveness (P=0.028) and suprasellar extension (P=0.019). The only effect of Gsp status was a significantly lower nuclear AHR score in Gsp(+) vs Gsp(-) tumours (P=0.025), irrespective of SSA. In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.

  4. Current Concepts and Diagnosis of IgG4-Related Pancreatitis (Type 1 AIP).

    PubMed

    Kawa, Shigeyuki

    2016-08-01

    Although now considered to be a member of the systemic entity of immunoglobulin G4- (IgG4-) related disease, IgG4-related pancreatitis is generally referred to as type 1 autoimmune pancreatitis (AIP). Type 1 AIP was established based on a pathological background of lymphoplasmacytic sclerosing pancreatitis, high serum IgG4 concentration, and abundant IgG4-bearing plasma cell infiltration. The characteristic clinical features of type 1 AIP, such as elderly male preponderance, obstructive jaundice, and mass-forming lesions in the pancreas, often mimic those of pancreatic cancer. However, because AIP responds favorably to corticosteroid treatment, careful differentiation from pancreatic cancer is required. An AIP diagnosis is currently based on the 2011 International Consensus Diagnostic Criteria for AIP, which are based on high sensitivity, selectivity, and accuracy. Over the long term, AIP can progress to a chronic condition, with pancreatic stone formation and atrophy resembling that of chronic pancreatitis. Although AIP has been linked to the complication of malignancies, it remains controversial whether an association exists between the disease and tumor formation.

  5. 75 FR 5846 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... available under Public Law No. 111-117 to accomplish Airport Improvement Program (AIP)-eligible...

  6. Career Education and Career Maturity.

    ERIC Educational Resources Information Center

    Trebilco, Geoffrey R.

    1984-01-01

    Investigated the relationships between career maturity and career curriculum in 38 Melbourne metropolitan secondary schools (N=2280 students) using an Australian adaption of the Career Development Inventory. Results confirmed that schools with career education programs achieved higher gains in student career maturity. (JAC)

  7. Career Education

    ERIC Educational Resources Information Center

    Forte, Enis; Goodfriend, Audrey

    1977-01-01

    Describes the career education program implemented into the specialized secretarial courses at Queensborough Community College (New York); discusses how the career library is organized and how career-development activities are incorporated into classes and evaluated. (TA)

  8. 75 FR 3954 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... Program (AIP)-eligible projects that the sponsor previously identified through the Airports Capital... AIP authorization and an extension of the FAA's spending authority from the Airport and Airway...

  9. 76 FR 6178 - Deadline for Notification of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement... under Public Law 111-322 to accomplish Airport Improvement Program (AIP)-eligible projects that the... without a legislative enactment that provides an additional AIP authorization and an extension of the...

  10. 77 FR 19408 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2012 AGENCY: Federal Aviation... Airport Improvement Program (AIP)-eligible projects that the sponsor previously identified through the... promulgated to expedite and prioritize the grant- making process. The AIP grant program is operating under...

  11. 78 FR 20167 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2013 AGENCY: Federal Aviation... Airport Improvement Program (AIP)-eligible projects that the sponsor previously identified through the... prioritize the grant- making process. The AIP grant program is operating under the requirements of Public...

  12. Future Careers in Geoscience

    NASA Astrophysics Data System (ADS)

    van der Vink, G. E.; van der Vink, G. E.

    2001-05-01

    A new generation of Geoscientists are abandoning the traditional pathways of oil exploration and academic research to pursue careers in public policy, international affairs, business, education and diplomacy. They are using their backgrounds in Geoscience to address challenging, multi-disciplinary problems of societal concern. To prepare for such careers, students are developing a broad understanding of science and a basic literacy in economics, international affairs, and policy-making.

  13. Identification and expression of mutations in the hydroxymethylbilane synthase gene causing acute intermittent porphyria (AIP).

    PubMed Central

    Solis, C.; Lopez-Echaniz, I.; Sefarty-Graneda, D.; Astrin, K. H.; Desnick, R. J.

    1999-01-01

    BACKGROUND: Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme hydroxymethylbilane synthase (EC 4.3.1.8; HMB-synthase). This disease is characterized by acute, life-threatening neurologic attacks that are precipitated by various drugs, hormones, and other factors. The enzymatic and/or biochemical diagnosis of AIP heterozygotes is problematic; therefore, efforts have focused on the identification of HMB-synthase mutations so that heterozygotes can be identified and educated to avoid the precipitating factors. In Spain, the occurrence of AIP has been reported, but the nature of the HMB-synthase mutations causing AIP in Spanish families has not been investigated. Molecular analysis was therefore undertaken in nine unrelated Spanish AIP patients. MATERIALS AND METHODS: Genomic DNA was isolated from affected probands and family members of nine unrelated Spanish families with AIP. The HMB-synthase gene was amplified by long-range PCR and the nucleotide sequence of each exon was determined by cycle sequencing. RESULTS: Three new mutations, a missense, M212V; a single base insertion, g4715insT; and a deletion/insertion, g7902ACT-->G, as well as five previously reported mutations (G111R, R116W, R149X R167W, and R173W) were detected in the Spanish probands. Expression of the novel missense mutation M212V in E. coli revealed that the mutation was causative, having <2% residual activity. CONCLUSIONS: These studies identified the first mutations in the HMB-synthase gene causing AIP in Spanish patients. Three of the mutations were novel, while five previously reported lesions were found in six Spanish families. These findings enable accurate identification and counseling of presymptomatic carriers in these nine unrelated Spanish AIP families and further demonstrate the genetic heterogeneity of mutations causing AIP. Images Fig. 1 PMID:10602775

  14. Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Daly, Adrian F; Beckers, Albert

    2015-03-01

    The most frequent conditions that are associated with inherited/familial pituitary adenomas are familial isolated pituitary adenoma (FIPA) and multiple endocrine neoplasia type 1 (MEN1), which together account for up to 5% of pituitary adenomas. One important genetic cause of FIPA are inactivating mutations or deletions in the aryl hydrocarbon receptor interacting protein (AIP) gene. FIPA is the most frequent clinical presentation of AIP mutations. This article traces the current state of knowledge regarding the clinical features of FIPA and the particular genetic, pathologic, and clinical characteristics of pituitary adenomas due to AIP mutations.

  15. How Workplace Experiences While at School Affect Career Pathways. A National Vocational Education and Training Research and Evaluation Program Report

    ERIC Educational Resources Information Center

    Smith, Erica; Green, Annette

    2005-01-01

    This report describes and analyses how the work activities undertaken by students while at school affect their post-school pathways into and between work and study. Increasingly, students are involved with workplaces while still at school. The three major ways in which this is happening (in order of extent of engagement) are through work…

  16. Pathways from Parental Stimulation of Children's Curiosity to High School Science Course Accomplishments and Science Career Interest and Skill

    ERIC Educational Resources Information Center

    Gottfried, Adele Eskeles; Preston, Kathleen Suzanne Johnson; Gottfried, Allen W.; Oliver, Pamella H.; Delany, Danielle E.; Ibrahim, Sirena M.

    2016-01-01

    Curiosity is fundamental to scientific inquiry and pursuance. Parents are important in encouraging children's involvement in science. This longitudinal study examined pathways from parental stimulation of children's curiosity per se to their science acquisition (SA). A latent variable of SA was indicated by the inter-related variables of high…

  17. K-12 Students, Teachers, Parents, Administrators and Higher Education Faculty: Partners Helping Rural Disadvantaged Students Stay on the Pathway to a Geoscience Career

    NASA Astrophysics Data System (ADS)

    Slattery, W.; Antonucci, C.; Myers, R. J.

    2013-12-01

    The National Science Foundation funded project K-12 Students, Teachers, Parents, Administrators and Higher Education Faculty: Partners Helping Rural Disadvantaged Students Stay on the Pathway to a Geoscience Career is a research-based proof of concept track 1 pilot project that tests the effectiveness of an innovative model for simultaneous K-12 teacher professional development, student learning and workforce development. The project builds a network of science experiences designed to keep eighth and ninth grade students from the Ripley, Union, Lewis, Huntington (RULH) Ohio school district on the path to a geoscience career. During each summer of the ongoing two-year project teams of RULH students, parents, teachers, administrators and college faculty traveled to the facilities of the New Jersey Sea Grant Consortium at Sandy Hook, New Jersey to study science from an Earth system perspective. Teachers had the opportunity to engage in professional development alongside their students. Parents participated in the science activities alongside their children. Administrators interacted with students, parents and their teachers and saw them all learning science in an engaging, collaborative setting. During the first academic year of the project professional development was provided to RULH teachers by a team of university scientists and geoscience educators from the Earth System Science Education Alliance (ESSEA), a National Science Foundation funded project. Teachers selected for professional development were from science disciplines, mathematics, language arts and civics. The teachers selected, taught and assessed ESSEA Earth system science modules to all eighth and ninth grade students, not just those that were selected to go on the summer trips to New Jersey. In addition, all ninth grade RULH students had the opportunity to take a course that includes Earth system science concepts that will earn them both high school and college science credits. Professional

  18. 77 FR 51948 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... Federal Aviation Administration 14 CFR Chapter 1 Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property; Correction AGENCY: Federal Aviation Administration (FAA... paragraph in the Proposed Policy Regarding Access to Airports From Residential Property that was...

  19. 76 FR 15028 - Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... Federal Aviation Administration Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential Property AGENCY: Federal Aviation Administration (FAA). ACTION: Interim policy; amendment to sponsor grant assurance 5. SUMMARY: This action adopts an interim policy amending...

  20. Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening.

    PubMed

    Pinho, Leandro Kasuki Jomori de; Vieira Neto, Leonardo; Wildemberg, Luiz Eduardo Armondi; Moraes, Aline Barbosa; Takiya, Christina M; Frohman, Lawrence A; Korbonits, Márta; Gadelha, Mônica R

    2010-11-01

    We present four FIPA kindred discussing clinical and molecular data and emphasizing the differences regarding AIP status, as well as the importance of genetic screening. Family 1 consists of five patients harboring somatotropinomas with germline E24X mutation in AIP. In one of the patients, acromegaly was diagnosed through active screening, being cured by surgery. Families 2 and 3 are composed of two patients with non-functioning pituitary adenomas. Family 4 comprises patients harboring a prolactinoma and a somatotropinoma. No mutations in AIP were found in these families. No patient in Family 1 was controlled with octreotide treatment, while the acromegalic patient in Family 4 was controlled with octreotide LAR. In conclusion, FIPA is a heterogeneous condition, which may be associated with AIP mutation. Genomic and clinical screening is recommended in families with two or more members harboring pituitary adenomas, allowing early diagnosis and better outcome.

  1. cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.

    PubMed

    Bolger, Graeme B; Bizzi, Mariana F; Pinheiro, Sergio V; Trivellin, Giampaolo; Smoot, Lisa; Accavitti, Mary-Ann; Korbonits, Márta; Ribeiro-Oliveira, Antonio

    2016-05-01

    PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore regulate numerous processes, including cell growth and differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations in AIP occur in approximately 20% of patients with Familial Isolated Pituitary Adenoma (FIPA) and 20% of childhood-onset simplex somatotroph adenomas. We therefore examined the protein expression of PDE4A4 and the closely related isoform PDE4A8 in normal human pituitary tissue and in pituitary adenomas. PDE4A4 had low expression in normal pituitary but was significantly overexpressed in somatotroph, lactotroph, corticotroph and clinically nonfunctioning gonadotroph adenomas (P<0.0001 for all subtypes). Likewise, PDE4A8 was expressed in normal pituitary and was also significantly overexpressed in the adenoma subtypes (P<0.0001 for all). Among the different adenoma subtypes, corticotroph and lactotroph adenomas were the highest and lowest expressed for PDE4A4, respectively, whereas the opposite was observed for PDE4A8. Naturally occurring oncogenic variants in AIP were shown by a two-hybrid assay to disrupt the ability of AIP to interact with PDE4A5. A reverse two-hybrid screen identified numerous additional variants in the tetratricopeptide repeat (TPR) region of AIP that also disrupted its ability to interact with PDE4A5. The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.

  2. AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.

    PubMed

    Fumoto, K; Lee, P-C; Saya, H; Kikuchi, A

    2008-07-24

    Glycogen synthase kinase-3 (GSK-3beta) regulates microtubule dynamics and cellular polarity through phosphorylating various microtubule associating proteins and plus-end tracking proteins. Although it was also reported that GSK-3beta is inactivated by protein kinase B at the spindle poles, functions and targets of GSK-3beta in the mitotic phase are unknown. Here, we identified Aurora-A-interacting protein (AIP), a negative regulator of Aurora-A, as a binding partner of GSK-3beta. AIP was colocalized with Aurora-A and GSK-3beta to the spindle poles in metaphase, and its depletion in cells stabilized and activated Aurora-A in early mitotic phase and caused mitotic cell arrest. Treatment of the cells with a GSK-3beta inhibitor reduced the protein level of Aurora-A and this reduction was suppressed by AIP knockdown. AIP was phosphorylated by GSK-3beta, and an AIP mutant in which the GSK-3beta phosphorylation site was mutated could bind and downregulate Aurora-A more efficiently. These results suggest that GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.

  3. Tech Prep Career Passports for Rewarding Futures.

    ERIC Educational Resources Information Center

    Rouse, Charles

    1995-01-01

    A Texas school system's Tech Prep Career Passport program equips high school students with skills consistent with their career goals and businesses with a better-prepared workforce. The Passport documents a graduate's completion of a three-course concentration within one of six tech-prep career pathways. A resume, letters of introduction and…

  4. Labor Market Information for Career Cluster Initiatives

    ERIC Educational Resources Information Center

    Miller, Jared

    2008-01-01

    In the midst of several upheavals in the American labor market, career clusters entered the scene in the late 1990s. Career clusters, sometimes called career pathways or ladders, have exploded in popularity and are now being implemented by most states. Job types can be grouped according to similar work interests and knowledge/skill requirements.…

  5. Choreographing Careers.

    ERIC Educational Resources Information Center

    Grossman, Barry B.; Blitzer, Roy J.

    1992-01-01

    Employees must take responsibility for their own career development by (1) linking career goals with organizational strategy; (2) being realistic about their supervisors' career management skills; (3) building an individual action plan; (4) using organizational resources; (5) having realistic expectations; and (6) making choices in the best…

  6. Acute interstitial pneumonia (AIP): relationship to Hamman-Rich syndrome, diffuse alveolar damage (DAD), and acute respiratory distress syndrome (ARDS).

    PubMed

    Mukhopadhyay, Sanjay; Parambil, Joseph G

    2012-10-01

    Acute interstitial pneumonia (AIP) is a term used for an idiopathic form of acute lung injury characterized clinically by acute respiratory failure with bilateral lung infiltrates and histologically by diffuse alveolar damage (DAD), a combination of findings previously known as the Hamman-Rich syndrome. This review aims to clarify the diagnostic criteria of AIP, its relationship with DAD and acute respiratory distress syndrome (ARDS), key etiologies that need to be excluded before making the diagnosis, and the salient clinical features. Cases that meet clinical and pathologic criteria for AIP overlap substantially with those that fulfill clinical criteria for ARDS. The main differences between AIP and ARDS are that AIP requires a histologic diagnosis of DAD and exclusion of known etiologies. AIP should also be distinguished from "acute exacerbation of IPF," a condition in which acute lung injury (usually DAD) supervenes on underlying usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF).

  7. Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study.

    PubMed

    Ferraù, Francesco; Romeo, P D; Puglisi, S; Ragonese, M; Torre, M L; Scaroni, C; Occhi, G; De Menis, E; Arnaldi, G; Trimarchi, F; Cannavò, S

    2016-12-01

    This multicentric study aimed to investigate the prevalence of the G protein-coupled receptor 101 (GPR101) p.E308D variant and aryl hydrocarbon receptor interacting protein (AIP) gene mutations in a representative cohort of Italian patients with acromegaly. 215 patients with GH-secreting pituitary adenomas, referred to 4 Italian referral centres for pituitary diseases, have been included. Three cases of gigantism were present. Five cases were classified as FIPA. All the patients have been screened for germline AIP gene mutations and GPR101 gene p.E308D variant. Heterozygous AIP gene variants have been found in 7 patients (3.2 %). Five patients carried an AIP mutation (2.3 %; 4 females): 3 patients harboured the p.R3O4Q mutation, one had the p.R304* mutation and the last one the IVS3+1G>A mutation. The prevalence of AIP mutations was 3.3 % and 2.8 % when considering only the patients diagnosed when they were <30 or <40-year old, respectively. Furthermore, 2.0 % of the patients with a pituitary macroadenoma and 4.2 % of patients resistant to somatostatin analogues treatment were found to harbour an AIP gene mutation. None of the patients was found to carry the GPR101 p.E308D variant. The prevalence of AIP gene mutations among our sporadic and familial acromegaly cases was similar to that one reported in previous studies, but lower when considering only the cases diagnosed before 40 years of age. The GPR101 p.E308D change is unlikely to have a role in somatotroph adenomas tumorigenesis, since none of our sporadic or familial patients tested positive for this variant.

  8. Afterschool: Supporting Career and College Pathways for Middle School Age Youth. MetLife Foundation Afterschool Alert. Issue Brief No. 46

    ERIC Educational Resources Information Center

    Afterschool Alliance, 2011

    2011-01-01

    In order to ensure that middle school youth are on a path toward higher education and careers, an early introduction to the importance of continuing education past high school is necessary. The middle school years are a vital time to teach the importance of college and career readiness and the linkages to success in life. This issue brief…

  9. [AIP mutations in familial and sporadic pituitary adenomas: local experience and review of the literature].

    PubMed

    Fajardo-Montañana, Carmen; Daly, Adrian F; Riesgo-Suárez, Pedro; Gómez-Vela, José; Tichomirowa, María A; Camara-Gómez, Rosa; Beckers, Albert

    2009-01-01

    Clinically relevant pituitary adenomas occur 3-5 times more frequently than previously thought. The majority are isolated cases, but their presentation can be familial in the setting of known syndromes such as multiple endocrine neoplasia (MEN)-1 and Carney complex. When 2 or more cases of pituitary adenomas occur in the same family in the absence of the above-mentioned syndromes, a diagnosis of FIPA (familial isolated pituitary adenomas) is made, which accounts for 1-2% of all pituitary adenomas. Mutations of the gene AIP (aryl hydrocarbon receptor-interacting protein) may account for 15% of FIPA families (50% of familial acromegaly), and as such the genetic causes continue to be studied. Also mutations in AIP can be detected in sporadic adenomas among young populations (< 30 years of age). We describe the characteristics of FIPA, detailing the study of a spanish family, in this case AIP mutation negative. Also, the reported findings in sporadic adenomas in the young population are detailed, accompanied by the description of a 19- year old patient with an intronic AIP mutation. Multicenter studies have provided understanding of aspects such as mutations in AIP; however, further studies are necessary to identify other genes involved in FIPA and sporadic pituitary adenomas occurring at a young age.

  10. Career Transitions and Career Success in the "New" Career Era

    ERIC Educational Resources Information Center

    Chudzikowski, Katharina

    2012-01-01

    The "new" career, most notably the boundaryless career, is associated with high career mobility, which is in turn associated with employability and career success of individuals. The current study examined how frequency, form (organisational, horizontal or vertical) and impact (objective career success) of career transitions have changed…

  11. Sustainable Management of Seagrass Meadows: the GEOSS AIP-6 Pilot

    NASA Astrophysics Data System (ADS)

    Santoro, Mattia; Pastres, Roberto; Zucchetta, Matteo; Venier, Chiara; Roncella, Roberto; Bigagli, Lorenzo; Mangin, Antoine; Amine Taji, Mohamed; Gonzalo Malvarez, Gonzalo; Nativi, Stefano

    2014-05-01

    Seagrass meadows (marine angiosperm plants) occupy less than 0.2% of the global ocean surface, annually store about 10-18% of the so-called "Blue Carbon", i.e. the Carbon stored in coastal vegetated areas. Recent literature estimates that the flux to the long-term carbon sink in seagrasses represents 10-20% of seagrasses global average production. Such figures can be translated into economic benefits, taking into account that a ton of carbon dioxide in Europe is paid at around 15 € in the carbon market. This means that the organic carbon retained in seagrass sediments in the Mediterranean is worth 138 - 1128 billion €, which represents 6-23 € per square meter. This is 9-35 times more than one square meter of tropical forest soil (0.66 € per square meter), or 5-17 times when considering both the above and the belowground compartments in tropical forests. According the most conservative estimations, about 10% of the Mediterranean meadows have been lost during the last century. To estimate seagrass meadows distribution, a Species Distribution Model (SDM) can be used. SDM is a tool that is used to evaluate the potential distribution of a given species (e.g. Posidonia oceanica for seagrass) on the basis of the features (bio-chemical-physical parameters) of the studied environment. In the framework of the GEOSS (Global Earth Observation System of Systems) initiative, the FP7 project MEDINA developed a showcase as part of the GEOSS Architecture Interoperability Pilot - phase 6 (AIP-6). The showcase aims at providing a tool for the sustainable management of seagrass meadows along the Mediterranean coastline by integrating the SDM with available GEOSS resources. This way, the required input data can be searched, accessed and ingested into the model leveraging the brokering framework of the GEOSS Common Infrastructure (GCI). This framework is comprised of a set of middle-ware components (Brokers) that are in charge of implementing the needed interoperability

  12. Viewing Clinical Research Career Development through the Lens of Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Bakken, Lori L.; Byars-Winston, Angela; Wang, Min-fen

    2006-01-01

    Issues such as, over commitment, insufficient time, and lack of funding, threaten physicians' entry and sustainability in a research career pathway. Social cognitive career theory is presented as a conceptual framework to critically examine the limitations of the National Institutes of Health's (NIH) efforts to promote the career development of…

  13. Design, construction and test of mercury thermometric cell in CENAMEP AIP

    NASA Astrophysics Data System (ADS)

    Ortega-Cortés, R.; Méndez-Lango, E.; Araolaza-Rodriguez, A.

    2013-09-01

    We present the results of the design, construction, filling and test of thermometric cell, to reproduce the triple point of mercury in the Temperature Laboratory of Centro Nacional de Metrología de Panamá AIP (CENAMEP AIP). This cell will be included in the group of thermometric cells of the laboratory. With this cell CENAMEP-AIP is covering the -39 °C to 660 °C range. This new cell offers the opportunity to reproduce the primary temperature defined by ITS-90 of -38.8344 ° C, and was built with 0.68 kg of mercury ultra-pure certified by the National Institute of Standards and Technology from United States (NIST-EEUU). The reproducibility obtained with thermometric cell of mercury is approximately one thousandth of kelvin (1 mK). This value satisfies according to current laboratory equipment.

  14. A longitudinal examination of adolescent career planning and exploration using a social cognitive career theory framework.

    PubMed

    Rogers, Mary E; Creed, Peter A

    2011-02-01

    This study used social cognitive career theory (Lent, Brown, & Hackett, 1994), as a framework to investigate predictors of career choice actions, operationalised as career planning and career exploration. The model was tested cross-sectionally and longitudinally with 631 high school students enrolled in Grades 10-12. Students completed measures of self-efficacy, outcome expectations, goals, supports and personality. Results of the hierarchical regression analyses indicated strong support for self-efficacy and goals predicting career planning and exploration across all grades at T1, and predicting change in career planning and exploration from T1 to T2. Whilst support for pathways among other predictor variables (personality, contextual influences and biographic variables) to choice actions was found, these pathways varied across grades at T1, and also from T1 to T2. Implications for social cognitive career theory, career counselling practice and future research are discussed.

  15. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene.

    PubMed

    Rowlands, J Craig; Urban, Jonathan D; Wikoff, Daniele Staskal; Budinsky, Robert A

    2011-01-01

    The human aryl hydrocarbon receptor (AHR) is a protein for which there is little evidence of polymorphic variability of functional consequence. It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP). There are limited data on AIP single nucleotide polymorphisms (SNPs) with potential functional consequences. We sequenced 103 human DNA samples within the open reading frames of the AIP locus using samples from six ethnic populations to further characterize AIP SNPs. Eight exonic SNPs were identified at the AIP locus, including three novel SNPs: T48T, L212L, and V302V. Combined with prior reports, there are now a total of 14 exonic SNPs that have been identified within AIP. Of these, six are non-synonymous and are therefore of potential functional importance, though only two of these (Q228K and A276V) were detected in the current study. The functional consequences of Q228K and A276V are unknown, although functional evidence from AIP SNPs associated with congenital pituitary tumors suggests that such amino acid changes are likely to have no effect or to decrease, rather than increase, sensitivity to dioxins. To date, no non-synonymous SNPs have been detected in the AHR-binding region of AIP.

  16. Should aip gene screening be recommended in family members of FIPA patients with R16H variant?

    PubMed

    Zatelli, Maria Chiara; Torre, Maria Luisa; Rossi, Rachele; Ragonese, Marta; Trimarchi, Francesco; degli Uberti, Ettore; Cannavò, Salvatore

    2013-06-01

    Germline mutations of aryl-hydrocarbon-receptor interacting protein (AIP) are associated with pituitary adenoma predisposition. They occur in 20 % of familial isolated pituitary adenoma (FIPA) and in about 3-5 % of sporadic pituitary adenomas, especially in early onset somatotropinomas and prolactinomas. Our aim was to evaluate the clinical and genetic features of a large Italian FIPA family, where an AIP variant was identified. AIP direct sequencing from genomic DNA was carried out in 16 available family members. AIP R16H carriers also underwent magnetic resonance imaging and hormonal assessments. AIP mutations were also searched in 16 patients with sporadic growth hormone-secreting pituitary adenoma and in 6 unrelated patients in whom pituitary adenoma was excluded. We found an AIP R16H variation in two family members harbouring a pituitary adenoma and in 6 unaffected family members. No AIP mutation was found neither in growth hormone-secreting pituitary adenoma patients, nor in the unrelated patients without pituitary adenoma. We report a FIPA family harbouring an AIP R16H change, supporting the hypothesis that the latter represents a variant of unknown significance.

  17. [The change of atherogenic index of plasma (AIP) level in type 2 diabetic pedigrees and the response of AIP to Acarbose or Glimepiride in therapy of type 2 diabetes mellitus].

    PubMed

    Yang, Bo; Tian, Haoming; Ren, Yan; Tong, Nanwei; Yu, Hongling; Han, Lingchuan; Ran, Xingwu

    2005-06-01

    The alterations in atherogenic index of plasma (AlP) in type 2 diabetic patients and their normoglycemic first-degree relatives (NFDR) were investigated, and the effects of Acarbose or Glimepiride on AIP in 99 type 2 diabetic patients were evaluated. Triglycerride (TG), total cholesterol, high density lipoprotein-cholesterol (HDL-C) levels were analyzed, and Log (TG/HDL-C) was calculated as AIP in 62 type 2 diabetic patients and their 67 NFDR from 29 type 2 diabetic pedigrees and in 45 healthy controls without family histories of diabetes. Also analyzed were the same parameters in 99 type 2 diabetic patients before and after therapy with Acarbose or Glimepiride. The results revealed that diabetic patients and their NFDR had significantly higher AIP than did the controls, whereas no significant differences were seen between diabetic patients and their NFDR. Positive correlation of AIP between type 2 diabetic patients and their offspring were observed (r = 0.241, P < 0.05). After 8 weeks therapy with Acarbose, the AIP of type 2 diabetic patients was decreased significantly, and no differences were observed for AIP levels in Glimepiride group although the AIP was lower when compared with the untreated level. As a significant inverse correlation of small dense low density lipoprotein (sdLDL) with AIP was confirmed, our data suggest that diabetic patients and their NFDR from type 2 diabetic pedigrees had significantly higher AIP than did controls; AIP could be decreased by therapy with Acarbose in type 2 diabetic patients; Glimepiride may bring potential benefit to type 2 diabetic patients by influencing sdLDL.

  18. Marine Careers.

    ERIC Educational Resources Information Center

    Gordon, Bernard L.

    The five papers in this publication on marine careers were selected so that science teachers, guidance councilors, and students could benefit from the experience and knowledge of individuals active in marine science. The areas considered are indicated by the titles: Professional Careers in Marine Science with the Federal Government, Marine Science…

  19. Career Path Guide for Adult Career Choices.

    ERIC Educational Resources Information Center

    Case, Clydia

    Intended for adults who are considering career choices or changes, this booklet provides opportunities for self-study and reflection in six career paths. The booklet begins with tips for long-term career survival and myths and realities of career planning. After a brief career survey, readers are introduced to six career paths: arts and…

  20. Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

    PubMed

    Vasquez, Joseph K; Tal-Gan, Yftah; Cornilescu, Gabriel; Tyler, Kimberly A; Blackwell, Helen E

    2017-02-16

    The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mimetics of AIPs for use as chemical tools to study QS in S. aureus. Herein, we report new peptidomimetic AgrC receptor inhibitors based on a tail-truncated AIP-II peptide that have almost analogous inhibitory activities to the parent peptide. Structural comparison of one of these peptidomimetics to the parent peptide and a highly potent, all-peptide-derived, S. aureus agr inhibitor (AIP-III D4A) revealed a conserved hydrophobic motif and overall amphipathic nature. Our results suggest that the AIP scaffold is amenable to structural mimicry and minimization for the development of synthetic agr inhibitors.

  1. Dichotomy, Dialectic and Dialogic: How Do Sociology Terms Assist Career Development Theory?

    ERIC Educational Resources Information Center

    Burns, Edgar A. M.

    2012-01-01

    Three concepts from sociology--dichotomy and two extensions, dialectic and dialogic--are considered here as social-psychological tools for career practitioners who analyse and investigate career patterns, career motivations and career pathways, whether at career start or at further points of transition. These terms have macro-social applications…

  2. Pathways to an Engineering Career

    ERIC Educational Resources Information Center

    Pearson, Willie, Jr.; Miller, Jon D.

    2012-01-01

    Utilizing data from the 20-year record of the Longitudinal Study of American Youth (LSAY), this analysis uses a set of variables to predict employment in engineering for a national sample of adults aged 34 to 37. The LSAY is one of the longest longitudinal studies of the impact of secondary education and postsecondary education conducted in the…

  3. Pathways Advancing Career Training Act

    THOMAS, 111th Congress

    Rep. DeLauro, Rosa L. [D-CT-3

    2009-04-23

    06/04/2009 Referred to the Subcommittee on Higher Education, Lifelong Learning, and Competitiveness. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  4. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1

    PubMed Central

    Costa, Luciana J; Chen, Nan; Lopes, Adriana; Aguiar, Renato S; Tanuri, Amilcar; Plemenitas, Ana; Peterlin, B Matija

    2006-01-01

    Background Nef is an accessory protein of primate lentiviruses, HIV-1, HIV-2 and SIV. Besides removing CD4 and MHC class I from the surface and activating cellular signaling cascades, Nef also binds GagPol during late stages of the viral replicative cycle. In this report, we investigated further the ability of Nef to facilitate the replication of HIV-1. Results To this end, first the release of new viral particles was much lower in the absence of Nef in a T cell line. Since the same results were obtained in the absence of the viral envelope using pseudo-typed viruses, this phenomenon was independent of CD4 and enhanced infectivity. Next, we found that Nef not only possesses a consensus motif for but also binds AIP1 in vitro and in vivo. AIP1 is the critical intermediate in the formation of multivesicular bodies (MVBs), which play an important role in the budding and release of viruses from infected cells. Indeed, Nef proliferated MVBs in cells, but only when its AIP1-binding site was intact. Finally, these functions of Nef were reproduced in primary macrophages, where the wild type but not mutant Nef proteins led to increased release of new viral particles from infected cells. Conclusion We conclude that by binding GagPol and AIP1, Nef not only proliferates MVBs but also contributes to the egress of viral particles from infected cells. PMID:16764724

  5. 75 FR 57829 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Federal Aviation Administration Airport Improvement Program (AIP): Policy Regarding Access to Airports... Proposed Policy Regarding Access to Airports From Residential Property that was published in the Federal... and clarify FAA policy concerning through-the-fence access to a Federally obligated airport from...

  6. 77 FR 44515 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Federal Aviation Administration 14 CFR Chapter I Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... policy, based on Federal law, concerning through-the-fence access to a federally obligated airport...

  7. School Board Improvement Plans in Relation to the AIP Model of Educational Accountability: A Content Analysis

    ERIC Educational Resources Information Center

    van Barneveld, Christina; Stienstra, Wendy; Stewart, Sandra

    2006-01-01

    For this study we analyzed the content of school board improvement plans in relation to the Achievement-Indicators-Policy (AIP) model of educational accountability (Nagy, Demeris, & van Barneveld, 2000). We identified areas of congruence and incongruence between the plans and the model. Results suggested that the content of the improvement…

  8. Careers in Medical Physics and the American Association of Physicists in Medicine

    NASA Astrophysics Data System (ADS)

    Amols, Howard

    2006-03-01

    The American Association of Physicists in Medicine (AAPM), a member society of the AIP is the largest professional society of medical physicists in the world with nearly 5700 members. Members operate in medical centers, university and community hospitals, research laboratories, industry, and private practice. Medical physics specialties include radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. The majority of AAPM members is based in hospital departments of radiation oncology or radiology and provide technical support for patient diagnosis and treatment in a clinical environment. Job functions include support of clinical care, calibration and quality assurance of medical devices such as linear accelerators for cancer therapy, CT, PET, MRI, and other diagnostic imaging devices, research, and teaching. Pathways into a career in medical physics require an advanced degree in medical physics, physics, engineering, or closely related field, plus clinical training in one or more medical physics specialties (radiation therapy physics, imaging physics, or radiation safety). Most clinically based medical physicists also obtain certification from the American Board of Radiology, and some states require licensure as well.

  9. Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP.

    PubMed

    Kamisawa, Terumi; Okazaki, Kazuichi; Kawa, Shigeyuki; Shimosegawa, Tooru; Tanaka, Masao

    2010-05-01

    Steroid therapy appeared to be a standard treatment for autoimmune pancreatitis (AIP), although some AIP patients improve spontaneously. The indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, and back pain, and the presence of symptomatic extrapancreatic lesions. Before steroid therapy, jaundice should be managed by biliary drainage in patients with obstructive jaundice, and blood glucose levels should be controlled in patients with diabetes mellitus. For the initial oral prednisolone dose for induction of remission, 0.6 mg/kg/day is recommended. The initial dose is administered for 2-4 weeks, and the dose is tapered by 5 mg every 1-2 weeks, based on changes in the clinical manifestations, biochemical blood tests (such as liver enzymes and IgG or IgG4 levels), and repeated imaging findings (US, CT, MRCP, ERCP, etc.). The dose is tapered to a maintenance dose (2.5-5 mg/day) over a period of 2-3 months. Steroid therapy should be stopped based on the disease activity in each case. Stopping of maintenance therapy should be planned within at least 3 years in cases with radiological and serological improvement. Re-administration or dose-up of steroid is effective for treating AIP relapses. The prognosis of AIP appears to be good over the short-term with steroid therapy. It is unclear whether the long-term outcome is good because there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy.

  10. Career Guidance

    ERIC Educational Resources Information Center

    Strong, J. D.

    1975-01-01

    Describes a joint effort of engineering education societies to produce up-to-date publications on engineering careers for high school students and comments on the effectiveness of cooperative and continuing effort. Identifies some of the publications now available. (GH)

  11. Critical Careers.

    ERIC Educational Resources Information Center

    Bowles, Roger A.

    2001-01-01

    Reports the critical shortage of qualified equipment technicians, especially in biomedical equipment. Cites the importance of encouraging careers in this field and describes a source of occupational information. (SK)

  12. Career Day

    NASA Video Gallery

    NASA's 2013 Career Days was a joint collaboration between NASA Langley and the Newport News Shipbuilding where 600 high school students from Virginia took on two design challenges -- designing a ca...

  13. Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort.

    PubMed

    Niyazoglu, Mutlu; Sayitoglu, Muge; Firtina, Sinem; Hatipoglu, Esra; Gazioglu, Nurperi; Kadioglu, Pinar

    2014-06-01

    Aryl hydrocarbon receptor-interacting protein (AIP) is associated with 15-20% of familial isolated pituitary adenomas and 50-80% of cases with AIP mutation exhibit a somatotropinoma. Herein we report clinical characteristics of a large family where AIP R304X variants have been identified. AIP mutation analysis was performed on a large (n = 52) Turkish family across six generations. Sella MRIs of 30 family members were obtained. Basal pituitary hormone levels were evaluated in 13 family members harboring an AIP mutation. Thirteen of 52 family members (25%) were found to have a heterozygous nonsense germline R304X mutation in the AIP gene. Seven of the 13 mutation carriers (53.8%) had current or previous history of pituitary adenoma. Of these 7 mutation carriers, all but one had somatotropinoma/somatolactotropinoma (85.7% of the pituitary adenomas). Of the 6 acromegaly patients with AIP mutation (F/M: 3/3) the mean age at diagnosis of acromegaly was 32 ± 10.3 years while the mean age of symptom onset was 24.8 ± 9.9 years. Three of the six (50%) acromegaly cases with AIP mutation within the family presented with a macroadenoma and none presented with gigantism. Biochemical disease control was achieved in 66.6% (4/6) of the mutation carriers with acromegaly after a mean follow-up period of 18.6 ± 17.6 years. Common phenotypic characteristics of familial pituitary adenoma or somatotropinoma due to AIP mutation vary between families or even between individuals within a family.

  14. A Career Roles Model of Career Development

    ERIC Educational Resources Information Center

    Hoekstra, Hans A.

    2011-01-01

    Career development is described as the interactive progression of internal career identity formation and the growth of external career significance. Argued is the need for a content model of career development where the field is dominated by process theories. A theory is put forward of career development crystallizing in the acquisition of career…

  15. Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation.

    PubMed

    van der Spuy, J; Cheetham, M E

    2004-08-01

    Mutations in the AIPL1 (aryl hydrocarbon receptor interacting protein-like 1) cause the blinding disease Leber's congenital amaurosis. AIPL1 is a homologue of the AIP. AIP functions as part of a chaperone heterocomplex to facilitate signalling by the AhR and plays an important role in regulating the nuclear translocation of the receptor. We review the evidence for the role of AIP in protein translocation and compare the potential functions of AIPL1 in the translocation of its interacting partner the NEDD8 ultimate buster protein 1.

  16. NMR assignments of the FKBP-type PPIase domain of the human aryl-hydrocarbon receptor-interacting protein (AIP).

    PubMed

    Linnert, Miriam; Haupt, Katja; Lin, Yi-Jan; Kissing, Sandra; Paschke, Anne-Katrin; Fischer, Gunter; Weiwad, Matthias; Lücke, Christian

    2012-10-01

    The aryl-hydrocarbon receptor-interacting protein (AIP) interacts with several protein binding partners and has been associated with pituitary tumor development. Here, we report nearly complete (1)H, (13)C and (15)N chemical shift assignments for the N-terminal AIP(2-166) segment, which has been predicted to represent a FKBP-type PPIase domain. Sequence alignment with the prototypic FKBP12, however, reveals disagreements between the AIP chemical shift index consensus and the corresponding FKBP12 secondary structure elements.

  17. An Explanatory Mixed-Methods Approach to Tracing "Career Pathways" Policy in Virginia: How School Counselors and Student Demographics Influence Implementation Fidelity

    ERIC Educational Resources Information Center

    Ormsmith, Michael Isaac

    2014-01-01

    This explanatory mixed-methods policy analysis describes how school counselors' thoughts and attitudes contribute to the implementation fidelity of the Academic and Career Plan (ACP) policy in a suburban Virginia school division. A quantitative survey investigated counselor thoughts about the policy, implementation behaviors, and counselor ideas…

  18. Insider Perspectives vs. Public Perceptions of ICT: Toward Policy for Enhancing Female Student Participation in Academic Pathways to Professional Careers in ICT

    ERIC Educational Resources Information Center

    Courtney, Lyn; Lankshear, Colin; Anderson, Neil; Timms, Carolyn

    2009-01-01

    This article reports findings of a national online survey of Australian women employed in Information and Communication Technology (ICT)-related careers. The Women in ICT Industry Survey was the culminating stage of a larger Australian Research Council Linkage Grant project investigating factors associated with low and declining female…

  19. AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience.

    PubMed

    Ramírez-Rentería, Claudia; Hernández-Ramírez, Laura C; Portocarrero-Ortiz, Lesly; Vargas, Guadalupe; Melgar, Virgilio; Espinosa, Etual; Espinosa-de-Los-Monteros, Ana Laura; Sosa, Ernesto; González, Baldomero; Zúñiga, Sergio; Unterländer, Martina; Burger, Joachim; Stals, Karen; Bussell, Anne-Marie; Ellard, Sian; Dang, Mary; Iacovazzo, Donato; Kapur, Sonal; Gabrovska, Plamena; Radian, Serban; Roncaroli, Federico; Korbonits, Márta; Mercado, Moisés

    2016-08-01

    Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic acromegaly, their prevalence among young patients is nonnegligible. The objectives of this study were to evaluate the frequency of AIP mutations in a cohort of Mexican patients with acromegaly with disease onset before the age of 30 and to search for molecular abnormalities in the AIP gene in teeth obtained from the "Tampico Giant". Peripheral blood DNA from 71 patients with acromegaly (51 females) with disease onset <30 years was analysed (median age of disease onset of 23 years) and correlated with clinical, biochemical and imaging characteristics. Sequencing was also carried out in DNA extracted from teeth of the Tampico Giant. Five patients (7 %) harboured heterozygous, germline mutations of the AIP gene. In two of them (a 9-year-old girl with gigantism and a young man with symptoms of GH excess since age 14) the c.910C>T (p.Arg304Ter), well-known truncating mutation was identified; in one of these two cases and her identical twin sister, the mutation proved to be a de novo event, since neither of their parents were found to be carriers. In the remaining three patients, new mutations were identified: a frameshift mutation (c.976_977insC, p.Gly326AfsTer), an in-frame deletion (c.872_877del, p.Val291_Leu292del) and a nonsense mutation (c.868A > T, p.Lys290Ter), which are predicted to be pathogenic based on in silico analysis. Patients with AIP mutations tended to have an earlier onset of acromegaly and harboured larger and more invasive tumours. A previously described genetic variant of unknown significance (c.869C > T, p.Ala299Val) was identified in DNA from the Tampico Giant. The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts. Our results support the need for genetic evaluation of patients with early onset acromegaly.

  20. Assessing Career Indecision.

    ERIC Educational Resources Information Center

    Osipow, Samuel H.

    1999-01-01

    Reviews the history of career decision-making measures such as My Vocational Situation, Career Decision Scale, Career Factors Inventory, and others. Assesses Holland's contribution to the accurate measurement of career indecision. (SK)

  1. Careers: Going Green while Doing Good

    ERIC Educational Resources Information Center

    Arnett, Sally E.; Kozlowski, Patti; Peach, Peggy

    2011-01-01

    Career and technical education (CTE) is starting to turn green. Due to a host of reports, research, workforce initiatives, and scholarly speaking engagements, it is evident that higher education and workforce consultants recognize the need for today's students to gain exposure to sustainability or green career pathways. But for secondary and…

  2. Do They Enter the Workforce? Career Choices after an Undergrad Research Experience

    NASA Astrophysics Data System (ADS)

    Greco, S.; Wissel, S.; Zwicker, A.; Ortiz, D.; Dominguez, A.

    2015-11-01

    Students in undergrad research internships go on to grad school at rates of 50-75% (Lopatto, 2007;Russell, 2005). NSF studied its undergrad program and found that 74% of physics interns (67% for engineering) go to grad school. PPPL undergrad interns were tracked for 10 years. Only 3% of physics PhD candidates are studying plasma physics, but 23% of our alumni that entered grad school did so in plasma. AIP reports that 60% of physics majors go to grad school (AIP, 2012), but 95% of PPPL interns have gone on to grad schools. Several programs track enrollment in grad school. AIP compiles statistics of undergrads who enter grad school and PhD students who work in the field. There has been no study of interns that follows the path from undergrad to grad school and then on to employment. Our tracking shows that most not only complete their advanced degrees but also stay in STEM fields following their academic careers. 88% of them become part of the STEM workforce, higher than the 82% of all physics PhDs employed in physics after obtaining their degree (AIP, 2014). PPPL puts more students in grad school in physics, and specifically plasma physics, and a higher percentage of those grad students stay in the STEM workforce.

  3. Acromegaly Is More Severe in Patients With AHR or AIP Gene Variants Living in Highly Polluted Areas.

    PubMed

    Cannavo, S; Ragonese, M; Puglisi, S; Romeo, P D; Torre, M L; Alibrandi, A; Scaroni, C; Occhi, G; Ceccato, F; Regazzo, D; De Menis, E; Sartorato, P; Arnaldi, G; Trementino, L; Trimarchi, F; Ferrau, F

    2016-04-01

    In this multicentric study, we aimed to correlate the occurrence of AHR and/or AIP. genes variants in acromegalic patients with the disease severity and/or with the response to somatostatin analogs (SSa) treatment, according to pollution exposition.

  4. AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma.

    PubMed

    Nishizawa, H; Fukuoka, H; Iguchi, G; Inoshita, N; Yamada, S; Takahashi, Y

    2013-05-01

    Pituitary adenoma with neuronal choristoma (PANCH) is a rare condition that includes ganglion cells and GH-producing tumor that is characterized by sparsely granulated somatotroph cell type. However, the pathophysiology of this condition remains to be elucidated. We report a case of 46-year-old woman with acromegaly caused by PANCH. The patient had a large and invasive macroadenoma that was resistant to preoperative therapy with somatostatin analogue (SSA) and dopamine agonist. Histological examination showed typical diffuse, chromophobe-type adenoma containing ganglion cells, and sparsely granulated somatotroph cell type, which were consistent with PANCH. Genetic analysis showed heterozygous germline missense mutation in the AIP gene that results in Y261X amino acid substitution. The clinical characteristics of acromegaly associated with AIP mutations are reportedly macroadenomas with tumor extension and invasion, lower decreases in GH and IGF-I and less tumor shrinkage with SSA treatment, and sparsely granulated somatotroph cell type, which are comparable with those observed in PANCH. Taken together, the mutation in AIP gene may explain the clinical characteristics and pathogenesis of PANCH.

  5. Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.

    PubMed

    Raitila, Anniina; Lehtonen, Heli J; Arola, Johanna; Heliövaara, Elina; Ahlsten, Manuel; Georgitsi, Marianthi; Jalanko, Anu; Paetau, Anders; Aaltonen, Lauri A; Karhu, Auli

    2010-10-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigenesis, we generated an Aip mouse model. Heterozygous mice developed normally but were prone to pituitary adenomas, in particular to those secreting GH. A complete loss of AIP was detected in these lesions, and full penetrance was reached at the age of 15 months. No excess of any other tumor type was found. Ki-67 analysis indicated that Aip-deficient tumors have higher proliferation rates compared with Aip-proficient tumors, suggesting a more aggressive disease. Similar to human AIP-deficient pituitary adenomas, immunohistochemical studies showed that expression of aryl hydrocarbon receptor nuclear translocator 1 or 2 (ARNT or ARNT2) protein was lost in the mouse tumors, suggesting that mechanisms of AIP-related tumorigenesis involve aberrant ARNT function. The Aip(+/-) mouse appears to be an excellent model for the respective human disease phenotype. This model constitutes a tool to further study AIP-associated pituitary tumorigenesis and may be potentially valuable in efforts to develop therapeutic strategies to treat pituitary adenomas.

  6. Career Education.

    ERIC Educational Resources Information Center

    Swanson, Gordon I.

    Five factors have influenced the movement in the United States now described as career education. Vocational educators might contend that this is another stage in the developmental history of vocational education, while others say that it is a natural consequence of concomitant advances in education. Another influence was work done by the National…

  7. Career Profiles.

    ERIC Educational Resources Information Center

    Dallas Independent School District, TX. Dept. of Research, Evaluation, and Information Systems.

    A guide to skilled occupations presents information on 30 occupations in narrative form. It is designed for students to use in career planning. For each occupation, the narrator describes, in conversational, first person form, the job, working conditions, necessary qualifications and personal characteristics, related school subjects, and…

  8. Career Builders

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2012-01-01

    While a main goal for corporate trainers traditionally has been to train employees to reach organizational goals, many trainers may find their roles expanding. With companies cutting back on staffing and consolidating multiple job roles into single positions, career development has taken on a much larger significance. At forward-thinking…

  9. CAREER DEVELOPMENT

    EPA Science Inventory

    The Baltimore Summit Project on Career Development/PERFORMS Enhancement/360 Evaluations for All has made some progress. We have identified the fact that we cannot change the current Pass/Fail PERFORMS system to a tiered system. The current pass/fail system does not have a mechani...

  10. IB Offering Certificate for Careers

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2012-01-01

    The International Baccalaureate (IB) organization, best known in the United States for its prestigious two-year diploma program for juniors and seniors, will enter new terrain this fall as it formally rolls out an initiative centered on a variety of career pathways that includes engineering, culinary arts, and automotive technology. The move comes…

  11. Career Key: A Career Library Management System.

    ERIC Educational Resources Information Center

    Smith, Eileen

    Career Key is a microcomputer library management system designed to access the cataloging records of the Career Development Library at Florida State University. The Career Key system, which provides access to a comprehensive and integrated multi-media collection of about 1,500 career resources, is based on a classification system involving 35…

  12. The Impact of Career Boundarylessness on Subjective Career Success: The Role of Career Competencies, Career Autonomy, and Career Insecurity

    ERIC Educational Resources Information Center

    Colakoglu, Sidika N.

    2011-01-01

    Based on the theoretical frameworks of the career enactment and the stress perspectives, this study develops and tests a model in which career boundarylessness affects subjective career success through its effect on three career competencies--knowing-why, knowing-how, and knowing-whom--and career autonomy and career insecurity. The results…

  13. Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

    PubMed Central

    Hernández-Ramírez, Laura C.; Martucci, Federico; Morgan, Rhodri M. L.; Trivellin, Giampaolo; Tilley, Daniel; Ramos-Guajardo, Nancy; Iacovazzo, Donato; D'Acquisto, Fulvio; Prodromou, Chrisostomos

    2016-01-01

    Context: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood. We have identified the primary mechanism of loss of function for missense AIPmuts. Objective: This study sought to analyze the mechanism/speed of protein turnover of wild-type and missense AIP variants, correlating protein half-life with clinical parameters. Design and Setting: Half-life and protein–protein interaction experiments and cross-sectional analysis of AIPmut positive patients' data were performed in a clinical academic research institution. Patients: Data were obtained from our cohort of pituitary adenoma patients and literature-reported cases. Interventions: Protein turnover of endogenous AIP in two cell lines and fifteen AIP variants overexpressed in HEK293 cells was analyzed via cycloheximide chase and proteasome inhibition. Glutathione-S-transferase pull-down and quantitative mass spectrometry identified proteins involved in AIP degradation; results were confirmed by coimmunoprecipitation and gene knockdown. Relevant clinical data was collected. Main Outcome Measures: Half-life of wild-type and mutant AIP proteins and its correlation with clinical parameters. Results: Endogenous AIP half-life was similar in HEK293 and lymphoblastoid cells (43.5 and 32.7 h). AIP variants were divided into stable proteins (median, 77.7 h; interquartile range [IQR], 60.7–92.9 h), and those with short (median, 27 h; IQR, 21.6–28.7 h) or very short (median, 7.7 h; IQR, 5.6–10.5 h) half-life; proteasomal inhibition rescued the rapid degradation of mutant proteins. The experimental half-life significantly correlated with age at diagnosis of acromegaly/gigantism (r = 0.411; P = .002). The FBXO3-containing SKP1–CUL1–F-box protein complex was identified as the E3 ubiquitin-ligase recognizing AIP. Conclusions: AIP is a stable protein, driven to ubiquitination by the SKP1–CUL1–F-box protein complex

  14. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.

    PubMed

    Morgan, Rhodri M L; Hernández-Ramírez, Laura C; Trivellin, Giampaolo; Zhou, Lihong; Roe, S Mark; Korbonits, Márta; Prodromou, Chrisostomos

    2012-01-01

    Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain of AIP at high resolution, which has allowed a detailed analysis of how disease-associated mutations impact on the structural integrity of the TPR domain. A subset of C-terminal α-7 helix (Cα-7h) mutations, R304* (nonsense mutation), R304Q, Q307* and R325Q, a known site for AhR and PDE4A5 client-protein interaction, occur beyond those that interact with the conserved MEEVD and EDDVE sequences of HSP90 and TOMM20. These C-terminal AIP mutations appear to only disrupt client-protein binding to the Cα-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved HSP90 motif, MEEVD, and the equivalent sequence (EDDVE) of TOMM20.

  15. Spatial Representations in Local Field Potential Activity of Primate Anterior Intraparietal Cortex (AIP).

    PubMed

    Lehmann, Sebastian J; Scherberger, Hansjörg

    2015-01-01

    The execution of reach-to-grasp movements in order to interact with our environment is an important subset of the human movement repertoire. To coordinate such goal-directed movements, information about the relative spatial position of target and effector (in this case the hand) has to be continuously integrated and processed. Recently, we reported the existence of spatial representations in spiking-activity of the cortical fronto-parietal grasp network (Lehmann & Scherberger 2013), and in particular in the anterior intraparietal cortex (AIP). To further investigate the nature of these spatial representations, we explored in two rhesus monkeys (Macaca mulatta) how different frequency bands of the local field potential (LFP) in AIP are modulated by grip type, target position, and gaze position, during the planning and execution of reach-to-grasp movements. We systematically varied grasp type, spatial target, and gaze position and found that both spatial and grasp information were encoded in a variety of frequency bands (1-13Hz, 13-30Hz, 30-60Hz, and 60-100Hz, respectively). Whereas the representation of grasp type strongly increased towards and during movement execution, spatial information was represented throughout the task. Both spatial and grasp type representations could be readily decoded from all frequency bands. The fact that grasp type and spatial (reach) information was found not only in spiking activity, but also in various LFP frequency bands of AIP, might significantly contribute to the development of LFP-based neural interfaces for the control of upper limb prostheses.

  16. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers

    PubMed Central

    Hernández-Ramírez, Laura C.; Gabrovska, Plamena; Dénes, Judit; Stals, Karen; Trivellin, Giampaolo; Tilley, Daniel; Ferraù, Francesco; Evanson, Jane; Ellard, Sian; Grossman, Ashley B.; Roncaroli, Federico; Gadelha, Mônica R.

    2015-01-01

    Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease. Objective: To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members. Design: This was an observational, longitudinal study conducted over 7 years. Setting: International collaborative study conducted at referral centers for pituitary diseases. Participants: FIPA families (n = 216) and sporadic young-onset (≤30 y) pituitary adenoma patients (n = 404) participated in the study. Interventions: We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant. Main Outcome Measure(s): We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis. Results: Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals. A total of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening. Conclusions: A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas. PMID

  17. A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred.

    PubMed

    Cansu, Güven Barış; Taşkıran, Bengür; Trivellin, Giampaolo; Faucz, Fabio R; Stratakis, Constantine A

    2016-07-01

    Familial isolated pituitary adenomas (FIPA) constitute 2-3% of pituitary tumours. AIP is the most commonly mutated gene in FIPA. We herein report a novel germline mutation of the AIP gene in a family with FIPA. We present two patients, a father and his 12-year-old daughter, diagnosed clinically and using laboratory measures with acromegaly-gigantism. Both underwent transsphenoidal hypophyseal surgery for macroadenomas. We initially detected a novel heterozygous germline AIP mutation, c.836G>A (p.W279*), in the father's DNA. We then found the same mutation in his affected daughter. Pituitary adenomas associated with AIP mutations mostly present as FIPA (68%) at an early age (78% occur at <30 years old). They are often growth hormone (GH) - or prolactin - secreting macroadenomas (88%) that have already extended beyond the sella at the time of diagnosis. Acromegalic cases are resistant to somatostatin analogues and multimodal management is frequently essential to control the disease. Our patients had normalized GH/IGF-1 values soon after surgery, although enough time may not have elapsed to reach final cure. While penetrance of the disease can be as low as 10% in FIPA, especially children and young patients with somatotropinoma and prolactinoma should be surveyed for inactivating mutations or deletions in AIP. Determining the causative mutations may be of assistance in early diagnosis, treatment success, and genetic counseling.

  18. Women's Career Development Patterns.

    ERIC Educational Resources Information Center

    Schreiber, Pamela J.

    1998-01-01

    Women's career development is characterized by balance of work and family, career interruptions, and diverse career paths. Alternative work arrangements such as flexible schedules, telecommuting, and entrepreneurial opportunities may offer women more options for work. (SK)

  19. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures (Invited)

    NASA Astrophysics Data System (ADS)

    Nativi, S.; Santoro, M.

    2009-12-01

    Currently, one of the major challenges for scientific community is the study of climate change effects on life on Earth. To achieve this, it is crucial to understand how climate change will impact on biodiversity and, in this context, several application scenarios require modeling the impact of climate change on distribution of individual species. In the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2), the Climate Change & Biodiversity thematic Working Group developed three significant user scenarios. A couple of them make use of a GEOSS-based framework to study the impact of climate change factors on regional species distribution. The presentation introduces and discusses this framework which provides an interoperability infrastructures to loosely couple standard services and components to discover and access climate and biodiversity data, and run forecast and processing models. The framework is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components publish climate, environmental and biodiversity datasets; e)Ecological Niche Model Server: this component is able to run one or more Ecological Niche Models (ENM) on selected biodiversity and climate datasets; f)Data Access

  20. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures

    NASA Astrophysics Data System (ADS)

    Nativi, Stefano; Santoro, Mattia

    2010-05-01

    In the last years, scientific community is producing great efforts in order to study the effects of climate change on life on Earth. In this general framework, a key role is played by the impact of climate change on biodiversity. To assess this, several use scenarios require the modeling of climatological change impact on the regional distribution of biodiversity species. Designing and developing interoperability infrastructures which enable scientists to search, discover, access and use multi-disciplinary resources (i.e. datasets, services, models, etc.) is currently one of the main research fields for the Earth and Space Science Informatics. This presentation introduces and discusses an interoperability infrastructure which implements the discovery, access, and chaining of loosely-coupled resources in the climatology and biodiversity domains. This allows to set up and run forecast and processing models. The presented framework was successfully developed and experimented in the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2) Climate Change & Biodiversity thematic Working Group. This interoperability infrastructure is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components

  1. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.

    PubMed

    Katayama, Hiroshi; Sasai, Kaori; Czerniak, Bogdan A; Carter, Jennifer L; Sen, Subrata

    2007-12-01

    Aurora-A is an oncogenic kinase that plays essential roles in mitosis as well as cell survival. Aurora-A interacting protein (AIP) was identified as a negative regulator of Aurora-A with its ectopic over expression inducing destabilization of Aurora-A protein. Here we present evidence that in human cells, contrary to the earlier report, AIP functions in stabilizing rather than destabilizing Aurora-A. Furthermore, AIP is phosphorylated on Serine 70 by Aurora-A but not Aurora-B and expression of phosphorylation mimic mutant of AIP results in prolonged protein stability compared to unphosphorylatable mutant. We observed that when co-expressed with AIP, protein levels of both Aurora-A and Aurora-B are markedly elevated regardless of their kinase activities and phosphorylation state of AIP. Interaction of Aurora kinases with AIP is necessary for this elevated stability. This phenomenon is commonly detected in several human cancer cell lines used in this study. Depletion of AIP by RNA interference decreased Aurora-A but not Aurora-B in two of the three cell lines analyzed, indicating that under physiological condition, AIP functions in stabilization of Aurora-A but not Aurora-B, though this regulation may be dependent on additional factors as well. Further, AIP siRNA induced cell cycle arrest at G2/M, which is consistent with anticipated loss of function of Aurora-A in these cells. Thus, our study provides the first evidence of a role for AIP in G2/M cell cycle progression by cooperatively regulating protein stabilization of its up-stream regulator, Aurora-A kinase through protein-protein interaction as well as protein phosphorylation.

  2. Planning a career as a children's nurse: the availability of career guidance during the nurse diploma course.

    PubMed

    Cox, Susanne J; Robinson, Sarah; Murrells, Trevor

    2003-12-01

    The recruitment and retention of registered children's nurses is paramount to the implementation of the national service framework for children's services. In recent years there have been increased career opportunities for children's nurses and a diversity of career pathways. Career guidance has a potential contribution to make to the effective management of nurses' careers. This article presents findings on child health diplomates' experiences of career guidance during the nurse diploma course. Findings indicate a substantial unmet demand for career guidance. The implications of the findings for child health nurses' careers are discussed and considered in relation to two key questions: should efforts be directed towards ensuring greater provision of career guidance, and if so, by whom?

  3. Web Services for Astronomical Databases: Connecting AIPS++ to the Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Douthit, M. C.

    2002-12-01

    In the year 2010, the NRAO will be operating four of the world's most powerful radio telescopes: GBT, EVLA, VLBA, and ALMA (with international partnership). Multi-Terabyte data sets will quickly accumulate with a rate of twenty-five to fifty Megabytes of data per second generated by ALMA and EVLA each. It will be imperative for scientists to possess software capable of automated data reduction, image synthesis, and archiving. With the evolution of AIPS++ and the recently developed concepts of the image pipeline, the participation of the NRAO in the virtual observatories of the future is now on the horizon giving birth to the need for fast archive access and web service development in AIPS++. When the software package began over 10 years ago, it was not designed for data transfer via the web. In response to the demands of the NVO, we have designed and implemented an application layer that will allow our system to communicate with others. Sponsored by the NRAO and California State University, San Marcos.

  4. Triangles have goals too: understanding action representation in left aIPS.

    PubMed

    Ramsey, Richard; Hamilton, Antonia F de C

    2010-07-01

    Humans freely interpret moving shapes as being "alive" and having social intentions, such as beliefs and desires. The brain systems underpinning these processes are the same as those used to detect animacy and infer mental states from human behaviour. However, it is not yet known if the brain systems that respond to human action-goals also respond to the action-goals of shapes. In the present paper, we used a repetition suppression paradigm during functional magnetic resonance imaging (fMRI) to examine brain systems that respond to the action-goals of shapes. Participants watched video clips of simple, geometrical shapes performing different 'take-object' goals. Repeated presentation of the same goal suppressed the blood oxygen level-dependent (BOLD) response in left anterior intraparietal sulcus (aIPS), a brain region known to distinguish the goals of human hand actions. This finding shows that left aIPS shows similar sensitivity to the action-goals of human and non-human agents. Our data complement previous work on animacy perception and mental state inference, which suggest components of the social brain are driven by the type of action comprehension that is engaged rather than by the form of the acting agent (i.e., human or shape). Further, the results have consequence for theories of goal understanding in situations without access to biological form or motion.

  5. A case of focal autoimmune pancreatitis (AIP) mimicking an intraductal papillary mucinous neoplasm (IPMN).

    PubMed

    Nakaji, So; Hirata, Nobuto; Fujii, Hiroyuki; Iwaki, Kosuke; Shiratori, Toshiyasu; Kobayashi, Masayoshi; Wakasugi, Satoshi; Ishii, Eiji; Takeyama, Hiroyuki; Hoshi, Kazuei

    2013-08-01

    The present case involved a 76-year-old man with a cystic mass in the head of his pancreas. The cystic lesion, which measured 17.7 × 9.8 mm, was first detected by ultrasonography (US) at the age of 72 years. Follow-up endoscopic ultrasonography (EUS) performed at 4 years after the lesion had first been detected revealed a mural nodule measuring 14.0 × 8.4 mm in the cyst. Endoscopic retrograde pancreatography (ERP) imaging revealed that the main pancreatic duct was in communication with the cyst and that there was no irregular narrowing of the main pancreatic duct. On the basis of these results, the patient was diagnosed with an intraductal papillary mucinous neoplasm (IPMN), and stomach-preserving pancreaticoduodenectomy was performed. A histopathological examination revealed that the interior of the cystic part of the lesion was lined by a pancreatic ductal epithelium. A pathological examination of the nodular lesion detected storiform fibrosis, severe lymphoplasmacytic infiltration, and hyperplasia in the pancreatic duct epithelium together with a small amount of mucus. On immunohistological staining, the infiltrating lymphoplasmacytes were found to be positive for IgG4. Accordingly, the patient was diagnosed with focal autoimmune pancreatitis (AIP). In conclusion, we reported a case of focal AIP mimicking IPMN. This case showed neither enlargement of the pancreas nor irregular narrowing of the main pancreatic duct.

  6. Advanced Information Processing System (AIPS)-based fault tolerant avionics architecture for launch vehicles

    NASA Technical Reports Server (NTRS)

    Lala, Jaynarayan H.; Harper, Richard E.; Jaskowiak, Kenneth R.; Rosch, Gene; Alger, Linda S.; Schor, Andrei L.

    1990-01-01

    An avionics architecture for the advanced launch system (ALS) that uses validated hardware and software building blocks developed under the advanced information processing system program is presented. The AIPS for ALS architecture defined is preliminary, and reliability requirements can be met by the AIPS hardware and software building blocks that are built using the state-of-the-art technology available in the 1992-93 time frame. The level of detail in the architecture definition reflects the level of detail available in the ALS requirements. As the avionics requirements are refined, the architecture can also be refined and defined in greater detail with the help of analysis and simulation tools. A useful methodology is demonstrated for investigating the impact of the avionics suite to the recurring cost of the ALS. It is shown that allowing the vehicle to launch with selected detected failures can potentially reduce the recurring launch costs. A comparative analysis shows that validated fault-tolerant avionics built out of Class B parts can result in lower life-cycle-cost in comparison to simplex avionics built out of Class S parts or other redundant architectures.

  7. Career Unit. Careers at an Airport.

    ERIC Educational Resources Information Center

    Booker, Billie

    This career exploration instructional unit on airport careers is one of several resulting from the rural southwestern Colorado CEPAC Project (Career Education Process of Attitude Change). This unit is designed to help students become aware of the different types of jobs connected with running an airport (e.g., ticket agent, pilot, skycap, traffic…

  8. Careers in Art. Career Development Project.

    ERIC Educational Resources Information Center

    Gergeceff, Lorraine; Wheeler, Geoffrey

    The 10 activities in the unit on art careers attempt to provide eighth and ninth grade students with opportunities for acquiring occupational information, to help students discover themselves in relation to art careers, and to explore various clusters of careers. The suggested occupational areas are: architecture, product design, cartooning,…

  9. Airport Careers. Aviation Careers Series. Revised.

    ERIC Educational Resources Information Center

    Zaharevitz, Walter

    This booklet, one in a series on aviation careers, outlines the variety of careers available in airports. The first part of the booklet provides general information about careers at airports, while the main part of the booklet outlines the following nine job categories: airport director, assistant airport director, engineers, support personnel,…

  10. Airline Careers. Aviation Careers Series. Revised.

    ERIC Educational Resources Information Center

    Zaharevitz, Walter

    This booklet, one in a series on aviation careers, outlines the variety of careers available in airlines. The first part of the booklet provides general information about careers in the airline industry, including salaries, working conditions, job requirements, and projected job opportunities. In the main part of the booklet, the following 22 job…

  11. The BHEF National Higher Education and Workforce Initiative: A Model for Pathways to Baccalaureate Attainment and High-Skill Careers in Emerging Fields, Part 3

    ERIC Educational Resources Information Center

    Fitzgerald, Brian K.; Barkanic, Steve; Cárdenas-Navia, Isabel; Chen, Janet; Elzey, Karen; Hughes, Debbie; Troyan, Danielle

    2016-01-01

    BHEF has achieved particular success in operationalizing its National Higher Education and Workforce Initiative (HEWI) through regional initiatives in data science and analytics (DSA). Leveraging its membership of corporate CEOs, university presidents and government agency leaders, BHEF seeded new undergraduate pathways in DSA at Case Western…

  12. EuroGEOSS/GENESIS ``e-Habitat'' AIP-3 Use Scenario

    NASA Astrophysics Data System (ADS)

    Mazzetti, P.; Dubois, G.; Santoro, M.; Peedell, S.; de Longueville, B.; Nativi, S.; Craglia, M.

    2010-12-01

    Natural ecosystems are in rapid decline. Major habitats are disappearing at a speed never observed before. The current rate of species extinction is several orders of magnitude higher than the background rate from the fossil record. Protected Areas (PAs) and Protected Area Systems are designed to conserve natural and cultural resources, to maintain biodiversity (ecosystems, species, genes) and ecosystem services. The scientific challenge of understanding how environmental and climatological factors impact on ecosystems and habitats requires the use of information from different scientific domains. Thus, multidisciplinary interoperability is a crucial requirement for a framework aiming to support scientists. The Group on Earth Observations (or GEO) is coordinating international efforts to build a Global Earth Observation System of Systems (GEOSS). This emerging public infrastructure is interconnecting a diverse and growing array of instruments and systems for monitoring and forecasting changes in the global environment. This “system of systems” supports multidisciplinary and cross-disciplinary scientific researches. The presented GEOSS-based interoperability framework facilitates the discovery and exploitation of datasets and models from heterogeneous scientific domains and Information Technology services (data sources). The GEO Architecture and Data Committee (ADC) launched the Architecture Implementation Pilot (AIP) Initiative to develop and deploy new processes and infrastructure components for the GEOSS Common Infrastructure (GCI) and the broader GEOSS architecture. The current AIP Phase 3 (AIP-3) aims to increase GEOSS capacity to support several strategic Societal Benefit Areas (SBAs) including: Disaster Management, Health/Air Quality, Biodiversity, Energy, Health/Disease and Water. As to Biodiversity, the EC-funded EuroGEOSS (http://www.eurogeoss.eu) and GENESIS (http://www.genesis-fp7.eu) projects have developed a use scenario called

  13. Career mapping: developing nurse leaders, reinvigorating careers.

    PubMed

    Shermont, Herminia; Krepcio, Deborah; Murphy, Jane M

    2009-10-01

    Nurse leaders must ensure the continued development and learning of all nurses, including those who postpone participation in existing professional development activities. In this article, the authors describe a career mapping program for nurses who have demonstrated reluctance in establishing and pursuing career advancement goals. The program incorporates a 2-tiered mentoring strategy and guides nurses in assessing their strengths and interests, developing career goals, and mapping out and implementing a career plan to meet personal and professional needs. The 18-month program resulted in career advancement for most participants and offers a model for leadership development.

  14. Vocopher: The Career Collaboratory

    ERIC Educational Resources Information Center

    Glavin, Kevin W.; Savickas, Mark L.

    2010-01-01

    Vocopher: The Career Collaboratory is an Internet-based website (http://www.vocopher.com) that contains free career instruments and educational materials intended for practitioners, researchers, and teachers of career development. The instruments include inventories and tests designed to measure the processes that shape career development and work…

  15. LGBT Career Development

    ERIC Educational Resources Information Center

    Gedro, Julie

    2007-01-01

    In this paper, I would like to open a conversation with my HRD colleagues about the issues related to Lesbian, Gay, Bisexual and Transgender (LGBT) career development. This paper provides some insights about LGBT career development, analyzing the factors that distinguish LGBT career development from heterosexual career development.

  16. Exploring Careers. Sales Occupations.

    ERIC Educational Resources Information Center

    Bureau of Labor Statistics (DOL), Washington, DC.

    "Exploring Careers" is a career education resource program, published in fifteen separate booklets, for junior high school-age students. It provides information about the world of work and offers its readers a way of learning about themselves and relating that information to career choices. The publications aim to build career awareness…

  17. Careers Working with Animals.

    ERIC Educational Resources Information Center

    Soltow, Willow

    1985-01-01

    Surveys careers in working with animals and gives suggestions for use of this topic in the classroom. Activities involve identifying reasons for choosing any career, careers involving animals (traditional and nontraditional), community personnel, and pros and cons of animal careers. Two student activity sheets are included for duplicating. (DH)

  18. Achieving Career Maturity.

    ERIC Educational Resources Information Center

    Hartung, Paul J.

    Gaining career decision-making and world-of-work knowledge, and increasing career planning and exploratory behavior represent key tasks of adolescent career development. To better understand this process, the extent to which personality type relates to career development in high school students is examined in this report. A cohort of 64 high…

  19. Exploring Career Options.

    ERIC Educational Resources Information Center

    Hellerman, Susan B., Ed.

    1994-01-01

    This newsletter theme issue offers advice to academically talented youth on exploring career options. It begins with an article titled "How To Think about Your Career When You Haven't Even Decided Where To Go to College." The article notes the hazards of early career choice and recognizes the career indecision often brought on by…

  20. Exploring Careers. Health Occupations.

    ERIC Educational Resources Information Center

    Bureau of Labor Statistics (DOL), Washington, DC.

    "Exploring Careers" is a career education resource program, published in fifteen separate booklets, for junior high school-age students. It provides information about the world of work and offers its readers a way of learning about themselves and relating that information to career choices. The publications aim to build career awareness by means…

  1. Familial isolated pituitary adenoma caused by a Aip gene mutation not described before in a family context.

    PubMed

    García-Arnés, J A; González-Molero, I; Oriola, J; Mazuecos, N; Luque, R; Castaño, J; Arraez, M A

    2013-12-01

    The cause of familial isolated pituitary adenomas (FIPA) remains unknown in a high percentage of cases, but the AIP gene plays an important role in the etiology. The aim of the study is to describe a family with FIPA syndrome and the results of genomic studies. A 16-year-old man had a giant prolactinoma resistant tomedical treatment with delayed growth and pubertal development. His mother had been previously diagnosed with a nonfunctioning pituitary macroadenoma. Transsphenoidal endoscopic resection was performed and a genetic study revealed a heterozygous mutation in exon 6: 974G>A (p.Arg325Gln). Because the AIP gene is a tumor suppressor gene, we searched for loss of heterozygosity within the AIP gene by amplifying exon 6 from tumor tissue of the patient. In the electropherogram, only the A allele was amplified (hemizygous state), indicating loss of the normal allele. We report a Spanish family with FIPA in whom a mutation in the AIP gene previously unreported in a familiar context was identified.

  2. Aggressive prolactinoma in a child related to germline mutation in the ARYL hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Naves, Luciana Ansaneli; Jaffrain-Rea, Marie-Lise; Vêncio, Sergio Alberto Cunha; Jacomini, Clausmir Zaneti; Casulari, Luiz Augusto; Daly, Adrian F; Beckers, Albert

    2010-11-01

    The objective of this study was to describe a familial screening for AIP mutations in the context of aggressive prolactinoma in childhood. A 12-year-old boy, presented headaches and bilateral hemianopsia. He had adequate height and weight for his age (50(th) percentile), Tanner stage G1 P1. His bone age was 10 years. Prolactin was 10.560 ng/mL (3-25), FSH and LH were undetectable, IGF-1, TSH, Free T4, ACTH, and cortisol were within normal ranges. MRI showed a pituitary macroadenoma, 5.3 X 4.0 X 3.5 cm with compression of the optic chiasm, bilateral cavernous sinus invasion, encasement of carotids, and extension to clivus. Surgical debulking was performed. Resistance to cabergoline was characterized and he was submitted to two surgeries and radiotherapy. Immunohistochemical evaluation included prolactin, ACTH, GH, FSH, LH,AIP, c-erb B2, Ki-67, and p53. Genomic DNA was isolated from the index case and 48 relatives, PCR and sequencing were performed.A germline A195V mutation in AIP was identified in the index case and in five asymptomatic relatives. Germline mutations in the AIP gene may be involved in the predisposition to pituitary adenoma formation, as cause or co-factor in pathogenesis of aggressive tumors in young patients.

  3. Representation of continuous hand and arm movements in macaque areas M1, F5, and AIP: a comparative decoding study

    NASA Astrophysics Data System (ADS)

    Menz, Veera Katharina; Schaffelhofer, Stefan; Scherberger, Hansjörg

    2015-10-01

    Objective. In the last decade, multiple brain areas have been investigated with respect to their decoding capability of continuous arm or hand movements. So far, these studies have mainly focused on motor or premotor areas like M1 and F5. However, there is accumulating evidence that anterior intraparietal area (AIP) in the parietal cortex also contains information about continuous movement. Approach. In this study, we decoded 27 degrees of freedom representing complete hand and arm kinematics during a delayed grasping task from simultaneously recorded activity in areas M1, F5, and AIP of two macaque monkeys (Macaca mulatta). Main results. We found that all three areas provided decoding performances that lay significantly above chance. In particular, M1 yielded highest decoding accuracy followed by F5 and AIP. Furthermore, we provide support for the notion that AIP does not only code categorical visual features of objects to be grasped, but also contains a substantial amount of temporal kinematic information. Significance. This fact could be utilized in future developments of neural interfaces restoring hand and arm movements.

  4. Toward a Framework for Multicultural STEM-Focused Career Interventions.

    PubMed

    Byars-Winston, Angela

    2014-12-14

    Numerous federal and national commissions have called for policies, funds, and initiatives aimed at expanding the nation's science, technology, engineering, and mathematics (STEM) workforce and education investments to create a significantly larger, more diverse talent pool of individuals who pursue technical careers. Career development professionals are poised to contribute to the equity discourse about broadening STEM participation. However, few are aware of STEM-related career development matters, career opportunities and pathways, or strategies for promoting STEM pursuits. The author summarizes STEM education and workforce trends and articulates an equity imperative for broadening and diversifying STEM participation. The author then offers a multicultural STEM-focused career development framework to encourage career development professionals' knowledge and awareness of STEM education and careers and delineates considerations for practice aimed at increasing the attainment and achievement of diverse groups in STEM fields.

  5. Toward a Framework for Multicultural STEM-Focused Career Interventions

    PubMed Central

    Byars-Winston, Angela

    2015-01-01

    Numerous federal and national commissions have called for policies, funds, and initiatives aimed at expanding the nation's science, technology, engineering, and mathematics (STEM) workforce and education investments to create a significantly larger, more diverse talent pool of individuals who pursue technical careers. Career development professionals are poised to contribute to the equity discourse about broadening STEM participation. However, few are aware of STEM-related career development matters, career opportunities and pathways, or strategies for promoting STEM pursuits. The author summarizes STEM education and workforce trends and articulates an equity imperative for broadening and diversifying STEM participation. The author then offers a multicultural STEM-focused career development framework to encourage career development professionals' knowledge and awareness of STEM education and careers and delineates considerations for practice aimed at increasing the attainment and achievement of diverse groups in STEM fields. PMID:25750480

  6. Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.

    PubMed

    Radian, Serban; Diekmann, Yoan; Gabrovska, Plamena; Holland, Brendan; Bradley, Lisa; Wallace, Helen; Stals, Karen; Bussell, Anna-Marie; McGurren, Karen; Cuesta, Martin; Ryan, Anthony W; Herincs, Maria; Hernández-Ramírez, Laura C; Holland, Aidan; Samuels, Jade; Aflorei, Elena Daniela; Barry, Sayka; Dénes, Judit; Pernicova, Ida; Stiles, Craig E; Trivellin, Giampaolo; McCloskey, Ronan; Ajzensztejn, Michal; Abid, Noina; Akker, Scott A; Mercado, Moises; Cohen, Mark; Thakker, Rajesh V; Baldeweg, Stephanie; Barkan, Ariel; Musat, Madalina; Levy, Miles; Orme, Stephen M; Unterländer, Martina; Burger, Joachim; Kumar, Ajith V; Ellard, Sian; McPartlin, Joseph; McManus, Ross; Linden, Gerard J; Atkinson, Brew; Balding, David J; Agha, Amar; Thompson, Chris J; Hunter, Steven J; Thomas, Mark G; Morrison, Patrick J; Korbonits, Márta

    2017-01-01

    The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) (or p.R304(*) ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304(*) carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011-0.0047) and zero in ROI (0-0.0014). R304(*) prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P < 0.05), but not in ROI (2/29, 6.8%) versus non-Irish patients (0-2.41%). Haploblock conservation supported a common ancestor for all the 18 identified Irish pedigrees (81 carriers, 30 affected). Time to most recent common ancestor (tMRCA) was 2550 (1,275-5,000) years. tMRCA-based simulations predicted 432 (90-5,175) current carriers, including 86 affected (18-1,035) for 20% penetrance. In conclusion, R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP-related disease.

  7. The Relationship between Disability Status, Career Beliefs, and Career Indecision.

    ERIC Educational Resources Information Center

    Enright, Mary Schaefer

    1996-01-01

    Tests two hypotheses: (1) career beliefs are related to career indecision, and (2) disability status influences the relationship between career beliefs and career indecision. Results yielded significant correlations between self-doubting career beliefs and career indecision, suggesting that disability may limit an individual's opportunity to…

  8. Applications of Motivational Interviewing in Career Counseling: Facilitating Career Transition

    ERIC Educational Resources Information Center

    Stoltz, Kevin B.; Young, Tabitha L.

    2013-01-01

    The Protean and Boundaryless career paradigms are calling for new ways to provide career counseling to clients. Career counselors need methods for facilitating client's career transition across all stages of career development. This facilitation requires career counselors to be armed with methods for promoting client's autonomy,…

  9. Seeding the Edge of Career and Technical Education

    ERIC Educational Resources Information Center

    Mojkowski, Charles; Washor, Elliot

    2007-01-01

    There is a resurging interest in career and technical education (CTE) from business leaders, policymakers and educators who have discovered, and in some cases rediscovered, the benefits of authentic applied learning embedded in career pathways that combine a robust mixture of relationships, relevance and rigor. Despite the growing interest, many…

  10. Goodbye Career, Hello Success.

    ERIC Educational Resources Information Center

    Komisar, Randy

    2000-01-01

    Success in today's economy means throwing out the old career rules. The "noncareer" career is driven by passion for the work and has the fluidity and flexibility needed in the contemporary workplace. (JOW)

  11. Career Key: A Career Library Management System.

    ERIC Educational Resources Information Center

    Smith, Eileen

    1983-01-01

    Describes a project undertaken at Florida State University to index the contents of its career library on a microcomputer. The Career Key provides easy access to materials and promotes information-seeking skills as a strategy for solving decision-making problems. (JAC)

  12. Comprehensive Career Development Project: Career Center Guide.

    ERIC Educational Resources Information Center

    Tennessee Univ., Knoxville. Dept. of Technological and Adult Education.

    This guide provides information for developing a career center that would serve as the major resource for information about the world of work. These steps in initiating a career center are outlined: designing and conducting a needs assessment, choosing the location, developing advisory committee and principal support, and staffing. The next…

  13. A Study of Career Patterns of the Presidents of Independent Colleges and Universities

    ERIC Educational Resources Information Center

    Hartley III, Harold V.; Godin, Eric E.

    2009-01-01

    "A Study of Career Patterns of the Presidents of Independent Colleges and Universities," examines the various career routes and other characteristics of first-time presidents. Using data from the American Council on Education American College President Study, CIC analyzed the career pathways; demographic characteristics such as gender,…

  14. The mid-career crisis in relation to Super's career and Erikson's adult development theory.

    PubMed

    Perosa, S L; Perosa, L M

    There is a need to integrate career development theory with adult development theory and a need to include females in the research. The purpose of this study was to investigate the mid-career crisis from the perspective of Erikson's and Super's theory, and to determine whether there are sex differences distinguishing mid-career changers. The sample consisted of 134 males and females who faced a mid-career crisis. They were categorized into three groups: changed, changing, and persisters representing different points on a decision-making continuum. All participants were given a structured interview, the Ego Identity Scale, the Tennessee Self Concept Scale, the Personality Research Form, and the Career Development Inventory. The results of the data analyses revealed that individuals who changed careers scored significantly higher on identity achievement and affiliation, and there was a significant positive correlation between identity achievement and self-concept. In terms of their vocational development, persisters were concerned with exploration tasks, whereas those who had changed careers described these tasks as declining in importance. In addition, five patterns of transition were identified. No sex differences emerged on the variables, indicating that career change as a pathway to identity achievement is similar for both sexes.

  15. Career Awareness: Grade 4.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    A broad educational background is necessary to meet ever changing occupational fields, and career education is an approach incorporating career information within the regular school curriculum. For the elementary level, career awareness is the main thrust in this program to integrate students and community. The introduction contains the format for…

  16. Minorities and Career Education.

    ERIC Educational Resources Information Center

    Davenport, Lawrence; Petty, Reginald

    This publication explores needed changes in the career preparation and education for minorities and examines the implications of career education emphases for minorities in the U.S. Contents include: (1) "An Overview of Minorities and Career Education" by L. Davenport and R. Petty, (2) "Public Schools, Public Policy, and Public Problems: Some…

  17. Career Awareness: Grade 5.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    A broad educational background is necessary to meet ever changing occupational fields, and career education is an approach incorporating career information within regular school curriculum. For the elementary level, career awareness is the main thrust in this program to integrate students and community. The format for grade five, performance…

  18. Career Awareness: Grade 6.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    A broad educational background is necessary to meet ever changing occupational fields, and career education is an approach incorporating career information within the regular school curriculum. For the elementary level, career awareness is the main thrust in this program to integrate students and community. The format for grade six, performance…

  19. Career Awareness: Grade 3.

    ERIC Educational Resources Information Center

    Boise City Independent School District, ID.

    A broad educational background is necessary to meet ever changing occupational fields, and Career Education is an approach incorporating career information within the regular school curriculum. For the elementary level, career awareness is the main thrust in this program to integrate students and community. The introduction contains the format for…

  20. National Park Service Careers.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    This booklet offers information on the employment needs of and career opportunities in the National Park Service. General information on the Service and employment is followed by specific information on these career opportunities: park ranger, park aide and technician, park police, administrative careers, and maintenance, trade, and craft…

  1. Career Development in Denmark.

    ERIC Educational Resources Information Center

    Plant, Peter

    Decentralization is the main feature of Danish governmental structures and the education and training system. The National Council on Educational and Vocational Guidance coordinates the career development field. Local and regional career development committees are organized under this judicial umbrella. Career education takes place as early as…

  2. Ohio Career Resource.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Career-Technical and Adult Education.

    This resource is designed to provide Ohio labor market information for use with advisory committees to stimulate and inform dialogue about the current evaluation and future planning of programs. It provides reports for 23 career fields in 6 career clusters. Each report highlights careers and occupations in the field and answers these questions:…

  3. Career streaming: a model of career development.

    PubMed

    Dyck, D; Walker, M

    1996-04-01

    1. A career is an individually perceived sequence of attitudes and behaviors associated with work related experiences and activities over the span of the person's life. 2. Every career ultimately reaches some sort of a plateau--a position from which someone is unlikely to advance to a higher level of responsibility in their career. The danger is they will become unmotivated and apathetic. 3. One method proposed for keeping employees challenged and interested is career streaming--a model of career development for employees within a defined professional field. The challenge is to provide a range of levels with defined skills for each level. The model developed for an occupational health service is provided as an example.

  4. Career Awareness, Career Planning, and Career Transition Needs among Sports Coaches

    ERIC Educational Resources Information Center

    Lavallee, David

    2006-01-01

    This study is conducted with 56 recently retired full-time sports coaches to examine the importance of career awareness, postsport career planning, and career transition needs. Results indicate that the individuals do not have a high level of career awareness, have done relatively little postsport career planning during their coaching careers, and…

  5. Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.

    PubMed Central

    Amberg, D C; Zahner, J E; Mulholland, J W; Pringle, J R; Botstein, D

    1997-01-01

    A search for Saccharomyces cerevisiae proteins that interact with actin in the two-hybrid system and a screen for mutants that affect the bipolar budding pattern identified the same gene, AIP3/BUD6. This gene is not essential for mitotic growth but is necessary for normal morphogenesis. MATa/alpha daughter cells lacking Aip3p place their first buds normally at their distal poles but choose random sites for budding in subsequent cell cycles. This suggests that actin and associated proteins are involved in placing the bipolar positional marker at the division site but not at the distal tip of the daughter cell. In addition, although aip3 mutant cells are not obviously defective in the initial polarization of the cytoskeleton at the time of bud emergence, they appear to lose cytoskeletal polarity as the bud enlarges, resulting in the formation of cells that are larger and rounder than normal. aip3 mutant cells also show inefficient nuclear migration and nuclear division, defects in the organization of the secretory system, and abnormal septation, all defects that presumably reflect the involvement of Aip3p in the organization and/or function of the actin cytoskeleton. The sequence of Aip3p is novel but contains a predicted coiled-coil domain near its C terminus that may mediate the observed homo-oligomerization of the protein. Aip3p shows a distinctive localization pattern that correlates well with its likely sites of action: it appears at the presumptive bud site prior to bud emergence, remains near the tips of small bund, and forms a ring (or pair of rings) in the mother-bud neck that is detectable early in the cell cycle but becomes more prominent prior to cytokinesis. Surprisingly, the localization of Aip3p does not appear to require either polarized actin or the septin proteins of the neck filaments. Images PMID:9247651

  6. Advanced Information Processing System (AIPS) proof-of-concept system functional design I/O network system services

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The function design of the Input/Output (I/O) services for the Advanced Information Processing System (AIPS) proof of concept system is described. The data flow diagrams, which show the functional processes in I/O services and the data that flows among them, are contained. A complete list of the data identified on the data flow diagrams and in the process descriptions are provided.

  7. Entrepreneurial Careers of Women in Zimbabwe

    ERIC Educational Resources Information Center

    Ncube, Lisa B.; Greenan, James P.

    2003-01-01

    The purpose of this study was to investigate the pathways of entrepreneurial career development and the processes involved for women to become entrepreneurs in Zimbabwe. Women entrepreneurs were studied to gain an understanding of why women chose self-employment and how local enterprise programs should be designed to benefit them. The study…

  8. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

    PubMed Central

    Silva, Daniela S.; Pereira, Liliana M. G.; Moreira, Ana R.; Ferreira-da-Silva, Frederico; Brito, Rui M.; Faria, Tiago Q.; Zornetta, Irene; Montecucco, Cesare; Oliveira, Pedro; Azevedo, Jorge E.; Pereira, Pedro J. B.; Macedo-Ribeiro, Sandra; do Vale, Ana; dos Santos, Nuno M. S.

    2013-01-01

    AIP56 (apoptosis-inducing protein of 56 kDa) is a major virulence factor of Photobacterium damselae piscicida (Phdp), a Gram-negative pathogen that causes septicemic infections, which are among the most threatening diseases in mariculture. The toxin triggers apoptosis of host macrophages and neutrophils through a process that, in vivo, culminates with secondary necrosis of the apoptotic cells contributing to the necrotic lesions observed in the diseased animals. Here, we show that AIP56 is a NF-κB p65-cleaving zinc-metalloprotease whose catalytic activity is required for the apoptogenic effect. Most of the bacterial effectors known to target NF-κB are type III secreted effectors. In contrast, we demonstrate that AIP56 is an A-B toxin capable of acting at distance, without requiring contact of the bacteria with the target cell. We also show that the N-terminal domain cleaves NF-κB at the Cys39-Glu40 peptide bond and that the C-terminal domain is involved in binding and internalization into the cytosol. PMID:23468618

  9. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    NASA Astrophysics Data System (ADS)

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-10-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  10. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.

    PubMed

    Barucker, Christian; Bittner, Heiko J; Chang, Philip K-Y; Cameron, Scott; Hancock, Mark A; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W; McKinney, R Anne; Multhaup, Gerhard

    2015-10-29

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically "trapping" low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  11. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    PubMed Central

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-01-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal. PMID:26510576

  12. Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

    PubMed

    Fisher, Robert D; Chung, Hyo-Young; Zhai, Qianting; Robinson, Howard; Sundquist, Wesley I; Hill, Christopher P

    2007-03-09

    ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form elongated arms that fold back into a "V." The structures also reveal conformational flexibility in the arms that suggests that the V domain may act as a flexible hinge in response to ligand binding. YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of the V, whereas CHMP4/ESCRT-III proteins bind a conserved hydrophobic patch on the Bro1 domain, and both interactions are required for virus budding. ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery.

  13. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.

    PubMed

    Nukaya, Manabu; Lin, Bernice C; Glover, Edward; Moran, Susan M; Kennedy, Gregory D; Bradfield, Christopher A

    2010-11-12

    The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development. In our model of AHR signaling, the receptor is found in a cytosolic complex with a number of molecular chaperones, including Hsp90, p23, and the aryl hydrocarbon receptor-interacting protein (AIP), also known as ARA9 and XAP2. To understand the role of AIP in adaptive and toxic aspects of AHR signaling, we generated a conditional mouse model where the Aip locus can be deleted in hepatocytes. Using this model, we demonstrate two important roles for the AIP protein in AHR biology. (i) The expression of AIP in hepatocytes is essential to maintain high levels of functional cytosolic AHR protein in the mammalian liver. (ii) Expression of the AIP protein is essential for dioxin-induced hepatotoxicity. Interestingly, classical AHR-driven genes show differential dependence on AIP expression. The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not. This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.

  14. Relation of Depression and Dysfunctional Career Thinking to Career Indecision.

    ERIC Educational Resources Information Center

    Saunders, Denise E.; Peterson, Gary W.; Reardon, Robert C.; Sampson, James P., Jr.

    2000-01-01

    A study of 215 students who completed career indecision, career thoughts, and depression measures showed that dysfunctional career thoughts were significant components of career indecision. Depression was significantly associated with career indecision, but it did not capture a significant independent variation in regression analyses. (SK)

  15. Fundamentos Basicos de Career Education. Monografia en Career Education. [Basic Fundamentals of Career Education. Monograph in Career Education].

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC.

    This document is the Spanish translation of ED 145 222, A Primer for Career Education. In this monograph, a view of the basic nature of the career education effort is discussed under the following topics: the basis of need for career education; the meaning and goals of career education; the difference between career education and vocational…

  16. Career Education for Marketing Majors.

    ERIC Educational Resources Information Center

    Berdine, W. R.; Hill, James R.

    1982-01-01

    This article proposes a course in career education as a method of integrating the various elements of career education for marketing students. Discusses student self-assessment, career awareness, skills development, career planning and placement, the written career plan, seminars, professional organizations, and work experience programs. (CT)

  17. Telling Stories of Career Assessment

    ERIC Educational Resources Information Center

    McMahon, Mary; Watson, Mark

    2012-01-01

    In the field of career development, there is an acknowledged relationship between career assessment and career counseling. Traditional career assessment and more recent narrative approaches to career counseling are perceived as having an uneasy relationship because of their different philosophical bases. A sustainable future story for the field…

  18. Career Pathways Skill-Building Instructional Model.

    ERIC Educational Resources Information Center

    Community Coll. of Rhode Island, Warwick.

    As part of an effort to develop a skill-based education program for students that relates academic skills with workplace skills, the Community College of Rhode Island developed a working instructional model consisting of 6 areas, or strands, and 31 skills. The model is directed at students in grades 9 through 12 and recognizes the importance of…

  19. Career pathways and ladders for photonics technicians

    NASA Astrophysics Data System (ADS)

    Guenther, Arthur H.; Hull, Daniel M.

    2005-10-01

    Since operational lasers were first demonstrated in 1960, the field of laser/electro-optics has become an indispensable, rapidly expanding component of modern industry. With the emergence of numerous medical and telecommunication applications in the 1980s, including fiber-optics, the field of laser/electro-optics evolved into photonics, a broad field encompassing optoelectronics, micro-optics, lasers, digital imaging, spectroscopy, optical instruments, and optical systems. Today photonics is not only a technology field in and of itself but is also an enabler of nearly every other technology field, including microtechnology, measurement and materials processing, remote sensing, photolithography for semiconductors, nanotechnology, electro-optics displays and imaging, and national defense.

  20. Pathways to Careers in Medicine and Health

    ERIC Educational Resources Information Center

    Fuchs, Bruce A.; Miller, Jon D.

    2012-01-01

    Physicians and other health professionals are an important part of the national scientific and technical workforce, and it is important to understand the factors that attract (or fail to attract) young adults into these fields. Using data from the 20-year record of the Longitudinal Study of American Youth (LSAY) and working within a social…

  1. A systems theory approach to career development: Exploring factors that affect science as a career choice

    NASA Astrophysics Data System (ADS)

    Liskey, Brian K.

    science (Group B) also had the lowest average values for achievement in science as assessed by science literacy score according to PISA. The United States (Group C) and the International Average (Group D) were both intermediate in each of the two categories. The analysis also showed an identical country group sequence from highest responses to lowest responses for the "systems" or variables of a) self-efficacy, b) preparation for a science career, and c) information about a career in science. The group sequence from high to low values was Group C, Group B, Group D, Group A. When comparing this country group sequence there appears to be a weak negative association between students in countries that expect a career in science and the values for self-efficacy, being prepared for, and informed about a career in science. The findings from this study indicate that the greatest factor affecting students' perception for expecting a career in science is high achievement in science. These results provide key insight on the Systems Theory of Career Development missing from the existing body of literature. Leaders in the fields of education and educational policy can use this information to guide practices and promote programs that will aid in higher achievement in science and engineering. This research can also be used by leaders in career counseling to advise students on appropriate career paths and prepare students for future careers in science and technology. Finally, leadership within state and federal institutions can utilize results from this study to guide future research and funding that encourages students on career pathways in the fields of Science Technology Engineering and Mathematics (STEM).

  2. Gender and medical careers.

    PubMed

    Riska, Elianne

    2011-03-01

    The concerns about physicians' career advancement tend to be raised in gender terms, because women presently constitute close to and will soon form a majority of the medical students in most western societies. The question is to what extent female and male medical students and residents today make similar or different career and lifestyle choices? Two major mechanisms have been referred to as the reason for gender differences in career paths for physicians. The major theoretical framework tends to be the socialization or sex-role theory and later versions of this explanatory framework. The other mechanism referred to is structural and points to the barriers or the concrete support that women and men experience in making their career decisions. Studies of medical students in the UK and US have shown that women students expected family demands to hamper career plans, while male students were less influenced by family concerns. The importance of role models and mentors in setting the career goals of medical students and residents has recently confirmed early studies of the topic. A number of studies have documented that early negative experiences or lack of encouragement in medical school deter women from choosing surgery as a career. Recent studies suggest that lifestyle choices rather than merely career advancement influence both female and male surgeons' career plans.

  3. Time course of information representation of macaque AIP neurons in hand manipulation task revealed by information analysis.

    PubMed

    Sakaguchi, Yutaka; Ishida, Fumihiko; Shimizu, Takashi; Murata, Akira

    2010-12-01

    We used mutual information analysis of neuronal activity in the macaque anterior intraparietal area (AIP) to examine information processing during a hand manipulation task. The task was to reach-to-grasp a three-dimensional (3D) object after presentation of a go signal. Mutual information was calculated between the spike counts of individual neurons in 50-ms-wide time bins and six unique shape classifications or 15 one-versus-one classifications of these shapes. The spatiotemporal distribution of mutual information was visualized as a two-dimensional image ("information map") to better observe global profiles of information representation. In addition, a nonnegative matrix factorization technique was applied for extracting its structure. Our major finding was that the time course of mutual information differed significantly according to different classes of task-related neurons. This strongly suggests that different classes of neurons were engaged in different information processing stages in executing the hand manipulation task. On the other hand, our analysis revealed the heterogeneous nature of information representation of AIP neurons. For example, "information latency" (or information onset) varied among individual neurons even in the same neuron class and the same shape classification. Further, some neurons changed "information preference" (i.e., shape classification with the largest amount of information) across different task periods. These suggest that neurons encode different information in the different task periods. Taking the present result together with previous findings, we used a Gantt chart to propose a hypothetical scheme of the dynamic interactions between different types of AIP neurons.

  4. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein.

    PubMed

    Kang, Byoung Heon; Xia, Fang; Pop, Ramona; Dohi, Takehiko; Socolovsky, Merav; Altieri, Dario C

    2011-05-13

    Survivin is a multifunctional protein with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings of its cytoprotective properties are poorly understood. Here we show that homozygous deletion of the aryl hydrocarbon receptor-interacting protein (AIP), a survivin-associated immunophilin, causes embryonic lethality in mice by embryonic day 13.5-14, increased apoptosis of Ter119(-)/CD71(-) early erythropoietic progenitors, and loss of survivin expression in its cytosolic and mitochondrial compartments in vivo. In import assays using recombinant proteins, AIP directly mediated the import of survivin to mitochondria, thus enabling its anti-apoptotic function, whereas a survivin 1-141 mutant that does not bind AIP was not imported to mitochondria and failed to inhibit apoptosis. AIP-directed mitochondrial import of survivin did not affect cell division, was independent of the organelle transmembrane potential, did not require the chaperone Heat Shock Protein 90 (Hsp90), and was inhibited by cytosolic factor(s) present in normal cells. shRNA knockdown of the mitochondrial import receptor Tom20 abolished mitochondrial import of survivin and sensitized tumor cells to apoptosis, whereas silencing of Tom70 had no effect. Therefore, an AIP-Tom20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of survivin.

  5. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.

    PubMed

    Junio, Hiyas A; Todd, Daniel A; Ettefagh, Keivan A; Ehrmann, Brandie M; Kavanaugh, Jeffrey S; Horswill, Alexander R; Cech, Nadja B

    2013-07-01

    Staphylococcus aureus infections acquired in hospitals now cause more deaths per annum in the US than does HIV/AIDS. Perhaps even more alarming is the rise in community associated methicillin-resistant S. aureus (CA-MRSA) infections, which have spread out of hospital settings and are infecting otherwise healthy individuals. The mechanism of enhanced pathogenesis in CA-MRSA remains unclear, but it has been postulated that high activity in the agr quorum-sensing system could be a contributing factor. The purpose of this study was to develop a quantitative method for analysis of autoinducing peptide I (AIP-I), the activating signal for the agr system in S. aureus. An effective method was developed using ultrahigh performance liquid chromatography (UHPLC) coupled to electrospray ionization mass spectrometry with an LTQ Orbitrap mass spectrometer. Relying on the exceptional resolving power and mass accuracy of this instrument configuration, it was possible to quantify AIP-I directly from the complex growth media of S. aureus cultures with a limit of detection (LOD) of 0.25μM and a linear dynamic range of 2.6 to 63μM. The method was then employed to monitor time-dependent production of AIP-I by S. aureus cultures, and it was observed that AIP-I production reached a maximum and leveled off after approximately 16h. Finally, it was determined that virulence of S. aureus was correlated with AIP-I production in some (but not all) strains analyzed.

  6. Health Inequality and Careers

    ERIC Educational Resources Information Center

    Robertson, Peter J.

    2014-01-01

    Structural explanations of career choice and development are well established. Socioeconomic inequality represents a powerful factor shaping career trajectories and economic outcomes achieved by individuals. However, a robust and growing body of evidence demonstrates a strong link between socioeconomic inequality and health outcomes. Work is a key…

  7. PHOENIX. Higher Wage Careers.

    ERIC Educational Resources Information Center

    Bismarck State Coll., ND.

    This document outlines the curriculum plan for the one-semester vocational-technical training component of PHOENIX: A Model Program for Higher-Wage Potential Careers offered by Bismarck State College (North Dakota) which prepares and/or retrains individuals for higher-wage technical careers. The comprehensive model for the program is organized…

  8. Careers in Health

    ERIC Educational Resources Information Center

    Roman-Vargas, Madeline; Estrada, Ricardo A.

    2008-01-01

    Carreras en Salud (Careers in Health) provides bilingual/bicultural individuals with a fully-supported customized career path for nursing and other allied health occupations bridging individuals from unemployment/underemployment to high-demand healthcare positions. Healthcare providers, elected officials, and community leaders have partnered with…

  9. Developing Careers (All Access)

    ERIC Educational Resources Information Center

    Emeagwali, N. Susan

    2005-01-01

    The DECA International Career Development Conference is the highlight of the year for the career and technical student organization, as marketing students demonstrate their skills, achievements and leadership abilities. DECA, which began in 1946 as the Distributive Education Clubs of America, is a national association of marketing students and the…

  10. One Stop Career Center.

    ERIC Educational Resources Information Center

    Wilson, Patricia

    With the aid of a U.S. Department of Labor grant, a number of one-stop career centers are being developed or have been implemented in California. A one-stop career center is a physical and electronic site where comprehensive services to job seekers and employers are available. These services include the following: assessment and eligibility…

  11. Foreign Languages and Careers.

    ERIC Educational Resources Information Center

    Honig, Lucille J.; Brod, Richard I.

    The purpose of the report is to explain why so many different types of people in so many different parts of the country need languages in their work, and why students planning their education in preparation for certain kinds of careers should be aware of these needs. The focus is mainly on language as an auxiliary skill, on the careers in which…

  12. Resources for Career Development.

    ERIC Educational Resources Information Center

    Indiana Univ., South Bend. Indiana Career Resource Center.

    The purpose of this volume is to provide educators, research workers, and others interested in career education with a catalog of ideas useful in promoting career development. This second edition of the bibliography identifies about 500 publications, reports, audio, video and manipulative materials available for purchase from commercial suppliers…

  13. The Lifetime Career Manager.

    ERIC Educational Resources Information Center

    Cabrera, James C.; Albrecht, Charles F., Jr.

    This book provides a road map for readers to plan and develop their careers. It suggests self-assessment, setting short- and long-term goals, and working toward identified goals in short increments. Beyond careers, attention is paid to lifestyles and personal values. The book is organized in 17 chapters that cover the following topics: (1) the…

  14. Foundations of Career Guidance.

    ERIC Educational Resources Information Center

    Ruff, Eldon E.

    The paper traces the evolution of career guidance from 1909 to the present. The predominant views before 1950 were almost entirely nondevelopmental, but in response to questions raised at a series of major national conferences in the 1960's and the national impact of the career education concept, the 1970's have seen a flurry of writings and…

  15. Career Education K-6.

    ERIC Educational Resources Information Center

    Lawrence Unified School District 497, KS.

    The elementary level career education instructional materials are arranged by grade level. Separate sections are devoted to each level and include an overview of the curriculum with objectives, activities, and resources (speakers, on-site visits, audio visuals, books, and kits) for each subject area covered. Emphasizing career awareness, each…

  16. Career Development in Spain.

    ERIC Educational Resources Information Center

    Talavera, Elvira Repetto; Moreno, Luisa Rodriguez; Romeo, Javier; Malik, Beatriz

    In Spain, the term "career development" refers to vocational or career guidance services. The 1983 Law on University Reform conferred on universities the freedom of teaching, endowing them with legal status and administrative powers. Thus, there are no regulations regarding guidance at this educational level. Guidance departments in…

  17. Career Development by Design.

    ERIC Educational Resources Information Center

    Hanna, Sharon L.

    This book is intended to guide the reader in the process of designing his or her career and achieving it. Chapter 1 begins with a look at self: developing areas of self, personality type, self-concept, and self-efficacy, making positive personality changes, sharpening basic skills, and evaluating career potential. Chapter 2 explores developing…

  18. Supporting Science Careers

    NASA Astrophysics Data System (ADS)

    Howard, Claire

    2014-08-01

    AGU is a diverse community of scientists from numerous countries. Our members focus on various research areas and are at different career stages. Supporting career scientists—those actively in the field, shaping policy, teaching, researching, and managing—is critical to ensuring future excellence in geoscience. This excellence, in turn, serves to better humanity.

  19. Foreign Languages in Careers.

    ERIC Educational Resources Information Center

    Dill, Wolfgang

    Foreign language study must be justified in relation to everyday situations, problems and needs. Second language education must therefore be integrated with career education. The Oregon State Department of Education sponsored a study for a group of educators to produce a transportable display and a video tape for career awareness purposes and to…

  20. Career Ladder: Vocational Assessment.

    ERIC Educational Resources Information Center

    Middletown Public Schools, CT.

    This packet on vocational assessment is one in a series of materials for use with career ladder students in the Middletown, Connecticut, Public Schools. Career ladder students are those ranging from the mentally retarded to the high-risk dropout in the regular education program. The document first explains the nature and purpose of vocational…

  1. What Is "Career Ready"?

    ERIC Educational Resources Information Center

    Association for Career and Technical Education, 2010

    2010-01-01

    All too often, the terms "career ready" and "college ready" are used interchangeably, and discussions around career readiness are limited to traditional academic skills that allow students to successfully enroll in postsecondary education. While there is no debate that a rigorous level of academic proficiency, especially in math and literacy, is…

  2. Career Interest Survey.

    ERIC Educational Resources Information Center

    Iowa State Dept. of Public Instruction, Des Moines. Guidance Services Section.

    The career interest survey consists of an expanded list of occupations and was developed to provide information to assist secondary school counselors and the exploring division of the Boy Scouts of America in developing career awareness and exploration programs and activities in the Polk County schools. The United States Office of Education's 15…

  3. Health Careers Film Guide.

    ERIC Educational Resources Information Center

    National Institutes of Health (DHEW), Bethesda, MD. Bureau of Health Manpower Education.

    This document, which represents a survey of the entire health career film field, was designed to provide information for people interested in a health career. The guide indicates that a major criteria for film selection was recency; however, some older films that give a fairly accurate image of a profession were included, with some emphasis given…

  4. Making Career Readiness Count

    ERIC Educational Resources Information Center

    Kreamer, Kate Blosveren; O'Hara, Marie; Curl, Cory

    2014-01-01

    There is growing consensus in states across the nation that the goal of the K-12 education system is to "prepare all students to graduate from high school ready for college and careers". Yet, in all but a handful of states, the priority goals set to drive student performance toward and beyond college and career readiness sputter out…

  5. Guidelines for Career Awareness.

    ERIC Educational Resources Information Center

    Mead, Rosemary; And Others

    These extensive guidelines for integrated career education programs at the elementary level were developed by a regional coordinator, an elementary teacher, and an intermediate teacher at a 2-week regional workshop in western Kentucky. The ten chapters include: (1) a rationale for developing career awareness, (2) self-evaluation guidelines for the…

  6. Career Education: [Junior High.

    ERIC Educational Resources Information Center

    Cortland-Madison Board of Cooperative Educational Services, Cortland, NY.

    The eighth in a series of nine career education guides contains six unit plans for grades 7-9. In general each unit presents goals, objectives, measuring devices, activities, instructional materials or resources, careers appropriate to the unit, a multimedia bibliography, and a unit evaluation form for teachers. Part one is a science unit which…

  7. Real Estate Career Opportunities.

    ERIC Educational Resources Information Center

    Lyon, Robert; Gardner, Gene

    Designed to provide basic information on the major entry-level career fields in real estate, this document can be used as a reference manual for counselors and instructors. The manual contains general information about the following real estate careers: salesperson, sales manager, broker, land developer, property manager, appraiser, mortgage loan…

  8. Procurement Career Management Handbook.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    This handbook is the result of the Treasury Department's efforts to increase professionalism among its procurement employees nationwide through its Procurement Career Management Program. First, the scope and objectives of the Procurement Career Management Program are discussed. The remaining sections of the handbook deal with the following program…

  9. A Career in Information.

    ERIC Educational Resources Information Center

    Debons, Anthony; And Others

    The best sources of information about educational requirements for careers in information sciences are the institutions that offer training programs in such careers. The American Society for Information Science maintains a file of information on institutions offering training programs in information science. This pamphlet is intended for general…

  10. Career Education Resource Materials.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Div. of Occupational Education Instruction.

    The learning materials identified in this resource guide are intended for teachers who are concerned with career education. A listing of the principal careers in each of the 15 occupational clusters is provided in the initial pages of the guide, based upon "An Analysis of Fifteen Occupational Clusters Identified by the U. S. Office of Education."…

  11. Career Information Handbook.

    ERIC Educational Resources Information Center

    Texas State Technical Inst., Waco.

    The handbook is a companion volume to "High School Career Interest and Information Survey" but its use extends to high school counselors, teachers, administrators and their students as an independent reference tool for occupational information. The manual is divided into sections corresponding to the fifteen career clusters identified by the U.S.…

  12. Contemporary Career Development Issues.

    ERIC Educational Resources Information Center

    Morrison, Robert F., Ed.; Adams, Jerome, Ed.

    This book provides practical guidance and examples for human resource development (HRD) specialists to use in the evaluation of their current career development programs and the design of new ones. "Issues in the Management of Careers" (Jerome Adams) provides a summary of each chapter and points out specific questions the chapter can answer.…

  13. Career Guidance Training.

    ERIC Educational Resources Information Center

    Young, John E.

    The 1972 Jet Propulsion Laboratory (JPL) Career Training Program was aimed at placing counselors in actual work situations (as new employees) to enable them to experience that which they must describe to students if they are to do an effective job in career counseling. The overall purpose was to give counselors or teachers and administrators an…

  14. Fashioning a Successful Career.

    ERIC Educational Resources Information Center

    Reese, Susan

    2003-01-01

    Describes the fashion design programs at the Center for Career and Technology Education in El Paso, Texas, the Fashion Institute of Design and Merchandising in California, and the Fashion Institute of Technology in New York. Provides sources of information about fashion careers. (JOW)

  15. Career Development of Women.

    ERIC Educational Resources Information Center

    Gorman, Anna M., Ed.; Vetter, Louise, Ed.

    The five major papers whose full texts are included address themselves to various topics that can influence the lives of women in their career choices and advancement. Federal Legislation: Impact on Women's Careers, Mary Allen Jolley, discusses sex discrimination, legal gains made over the past 10 years, sex role stereotyping, and vocational…

  16. Exploration of Retailing Careers.

    ERIC Educational Resources Information Center

    Wilkie, Barbara J.

    Designed as a semester unit of instruction at the middle or junior high school level in the exploration of retailing careers, this distributive education curriculum guide is divided into two sections: The Teacher's Guide and Student Materials. One of the elective courses intended as a followup to "Orientation to Marketing Careers," it provides the…

  17. Careers Booklet. Project SEARCH.

    ERIC Educational Resources Information Center

    Heart of the Earth Survival School, Minneapolis, MN.

    Developed by the staff of Project SEARCH, this booklet is designed to assist American Indian adults of the Minneapolis-St. Paul area in an exploration of careers. As noted by the introduction, it may also be of interest to Indian high school students, college students, and others who are looking for ideas about the kinds of careers available. The…

  18. Careers for Youth. AACE Distinguished Member Series on Career Education.

    ERIC Educational Resources Information Center

    Gnaedinger, John P.

    Four papers by John Gnaedinger focus on the Careers for Youth (CFY) program. "CFY: The Model Program" describes the three phases of development incorporated in CFY: career awareness in grades 6 and 7; career exploration that begins at the end of grade 7; and career preparation that continues through the high school years. The sweat-equity program…

  19. Careers and Career Lines: Concepts, Measures and Explanations.

    ERIC Educational Resources Information Center

    Otto, Luther B.; And Others

    This document reports on research in progress on the nature and dimensions of careers. Following a brief introduction, the second section develops and illustrates new concepts and measures for analyzing career lines. The following concepts are defined in terms of the chosen conceptualization: job, career, career lines (regularities in job…

  20. Career Counseling and Career Courses: Process, Impact and Outcomes

    ERIC Educational Resources Information Center

    McClair, Vetisha L.

    2010-01-01

    The current study seeks to build on to the existing literature on career interventions by empirically examining possible outcomes of two of the most widely utilized career interventions, career counseling and career courses. This investigation used Critical Ingredients (Brown & Ryan Krane, 2000; Brown, et al., 2003; Ryan, 1999) to assess the…

  1. Elementary Career Education Guide, Volume 2: Career Awareness--Primary.

    ERIC Educational Resources Information Center

    Watertown Independent School District 1, SD.

    Volume 2 of the six-volume articulated elementary education career guide deals with the career awareness level of career education and aims at developing student career identity. The lessons in the volume are divided and color-coded by grade level (early childhood, primary levels one, two, and three corresponding respectively with grades K-three,…

  2. The Evaluation of Career Indecision in Career Development.

    ERIC Educational Resources Information Center

    Lewko, John H.

    1994-01-01

    Examines research on career indecision through review of literature on variables consistently investigated as predictors of career indecision and tools incorporated to measure career indecision. Raises eight issues that would impact on evaluation efforts in area of career indecision. Encourages practitioners to test validity of mental models that…

  3. Developmental Issues in Career Maturity and Career Decision Status.

    ERIC Educational Resources Information Center

    Patton, Wendy; Creed, Peter A.

    2001-01-01

    Reports cross-sectional data from 1,971 Australian adolescents who completed the Career Decision Scale and the Career Development Inventory. Results illustrate a developmental progression in career maturity, although a less uniform pattern emerged with gender differences. Findings regarding career indecision also presented a complex picture and…

  4. Social Cognitive Career Theory and Middle School Student Career Exploration

    ERIC Educational Resources Information Center

    Sickinger, Pamela H.

    2013-01-01

    Within the framework of social cognitive career theory, social cognitive career variables, demographic variables, and the contextual variable, parent support, were examined to determine their predictive value for eighth-grade students' career exploration behavior. Results suggest that the social cognitive career variable, intentions/goals,…

  5. Career Opportunities Instructional Guide. Career Investigation. Revised.

    ERIC Educational Resources Information Center

    Hendrix, Mary; Cegiel, Linda

    This instructional guide on career opportunities contains 17 units on the following topics: locating information about occupations; introduction to the occupational clusters; agribusiness and natural resources; business and office; communications and media; construction; consumer and homemaking; environment; fine arts and humanities; health;…

  6. Career Education and Basic Education.

    ERIC Educational Resources Information Center

    Collins, Owen, Ed.

    To provide a reliable correlation of how the "basics" are strengthened by implementing career education units, concepts, and/or skills into existing curricula, the Career Education Project of the Kentucky Valley Educational Cooperative studied the achievement of career education and non-career education students in reading, mathematics,…

  7. Exploring Careers. Mechanics and Repairers.

    ERIC Educational Resources Information Center

    Bureau of Labor Statistics (DOL), Washington, DC.

    "Exploring Careers" is a career education resource program, published in fifteen separate booklets, for junior high school-age students. It provides information about the world of work and offers its readers a way of learning about themselves and relating that information to career choices. The publications aim to build career awareness…

  8. Career Education: Leadership in Learning.

    ERIC Educational Resources Information Center

    Arizona State Dept. of Education, Phoenix.

    An overview is offered of the Plan for Arizona's Career Education, a 10-year career education program developed by the Arizona State Board of Education. The handbook includes a definition of career education, the elements of career education, program organization, teacher support, impact on counseling, a description of the Arizona Clearinghouse in…

  9. Exploring Careers in Ornamental Horticulture.

    ERIC Educational Resources Information Center

    Cincinnati Public Schools, OH.

    The career exploration program for grades 9 through 10, as part of a comprehensive K through 10 career development program, attempts to develop an awareness of and appreciation for work, extend knowledge of the variety of career opportunities, and provide experiences in career areas of individual interest. The document, a collection of materials…

  10. Holland's Theory and Career Assessment.

    ERIC Educational Resources Information Center

    Reardon, Robert C.; Lenz, Janet G.

    1999-01-01

    Career assessment activities in the Self-Directed Search and constructs in Holland's theory increase understanding of an individual's personal career theory (PCT). The PCT provides information about a person's readiness for career decision making and the types of career interventions that might be effective. (Author/SK)

  11. Exploring Careers in Law Enforcement.

    ERIC Educational Resources Information Center

    Cincinnati Public Schools, OH.

    The career exploration program for grades 9 through 10, as part of a comprehensive K through 10 career development program, attempts to develop an awareness of and appreciation for work, extend knowledge of the variety of career opportunities, and provide experiences in career areas of individual interest. The document, a collection of materials…

  12. Career Exploration among College Students

    ERIC Educational Resources Information Center

    Fouad, Nadya A.; Ghosh, Arpita; Chang, Wen-hsin; Figueiredo, Catia; Bachhuber, Thomas

    2016-01-01

    College is a significant time for undergraduates to declare majors and choose career paths. For many undergraduates, choosing both a major and a career path is challenging. Research shows that many universities deliver career interventions through dedicated career decision-making courses (Mead & Korschgen, 1994). However, there has been…

  13. Exploring Careers in Environmental Protection.

    ERIC Educational Resources Information Center

    Cincinnati Public Schools, OH.

    The career exploration program for grades 9 through 10, as part of a comprehensive K-10 career development program, attempts to develop an awareness of and appreciation for work, extend knowledge of the variety of career opportunities, and provide experiences in career areas of individual interest. The document, a collection of materials…

  14. The Status of Career Education.

    ERIC Educational Resources Information Center

    Eicke, F. J.; Pappas, Anthony V., Jr.

    1974-01-01

    Drawing upon career education leaders and specialists as sources, the authors explore the status of career education by discussing definitions, program dimensions, roles of career education, program evaluation, and recommendations for the State of Mississippi. The most common definitions of career education focus on five aspects: (1) career…

  15. Enhancing Students' Transitions to College and Careers: A Case Study of Distributed Leadership Practice in Supporting a High School Career Academy Model

    ERIC Educational Resources Information Center

    Malin, Joel R.; Hackmann, Donald G.

    2017-01-01

    Creating effective pathways for students to transition from high school to college or career is immensely important and, although challenging, some have developed promising approaches. This case study examined how formal and informal leaders in an urban high school and district collaborated to implement a college and career academy model,…

  16. Tube Maps for Effective Geoscience Career Planning and Development

    NASA Astrophysics Data System (ADS)

    Keane, C. M.; Wilson, C. E.; Houlton, H. R.

    2013-12-01

    One of the greatest challenges faced by students and new graduates is the advice that they must take charge of their own career planning. This is ironic as new graduates are least prepared to understand the full spectrum of options and the potential pathways to meeting their personal goals. We will examine the rationale, tools, and utility of an approach aimed at assisting individuals in career planning nicknamed a "tube map." In particular, this approach has been used in support of geoscientist recruitment and career planning in major European energy companies. By utilizing information on the occupational sequences of geoscience professionals within an organization or a community, a student or new hire can quickly understand the proven pathways towards their eventual career goals. The tube map visualizes the career pathways of individuals in the form of a subway map, with specific occupations represented as "stations" and pathway interconnections represented as "transfers." The major application of this approach in the energy sector was to demonstrate both the logical career pathways to either senior management or senior technical positions, as well as present the reality that time must be invested in "lower level" jobs, thereby nullifying a persistent overinflated sense of the speed of upward mobility. To this end, we have run a similar occupational analysis on several geoscience employers, including one with somewhat non-traditional geoscience positions and another that would be considered a very traditional employer. We will examine the similarities and differences between the resulting 'tube maps,' critique the tools used to create the maps, and assess the utility of the product in career development planning for geoscience students and new hires.

  17. Balancing Family and Career

    NASA Astrophysics Data System (ADS)

    Andam, Aba Bentil; Dawson, Silvina Ponce; Horton, K. Renee; Sandow, Barbara

    2005-10-01

    In essentially all countries, responsibilities for child care, cooking, cleaning, and other homemaking tasks fall predominantly on the wife and mother. In addition, the childbearing years come during the period when a physicist must study hard, work long hours on research, and take temporary positions, often abroad. Thus, balancing family and career has long been one of the major barriers to women's participation in science and engineering fields, including physics. While many young women believe that they must choose between having children and having a science career, the fact is that the majority of women physicists in both developing and developed countries have successfully done both. This paper summarizes some ideas and recommendations raised in discussions, especially focused on easing the challenges of having children while in temporary jobs, returning to physics after a career break, the need for "family-friendly" working conditions, and the dual-career problem facing couples where both are scientists.

  18. Videotaping for Career Awareness.

    ERIC Educational Resources Information Center

    Fitzgerald, Clifford

    1980-01-01

    Discusses the value of videotaping student interviews of workers as a way of teaching career awareness. Includes details of preparation--selecting occupations, planning the interview, becoming familiar with the equipment-- and taping tips. (JOW)

  19. The Career Development Workshop

    ERIC Educational Resources Information Center

    Marsh, P. J.

    1973-01-01

    This article describes a career planning workshop for managers and its purpose is to support and accelerate the process of individual development without organizational coercion or manipulation. (Author/RK)

  20. Career Day 2012

    NASA Video Gallery

    More than 200 high school juniors and seniors with interests in science, technology, engineering and math met one-on-one with professionals at NASA's Langley Research Center during Career Day 2012,...

  1. Agribusiness Career Exploration Winner

    ERIC Educational Resources Information Center

    Gutshall, Bill

    1976-01-01

    Describes the planning, development, status, and instructional materials used in a career awaremess program in agribusiness in Chillicothe, Missouri. The four classes in the program and the results of an appraisal are also described. (HD)

  2. Insights on STEM Careers

    SciTech Connect

    Wendelberger, Joanne Roth

    2014-11-05

    This presentation will provide career advice for individuals seeking to go beyond just having a job to building a successful career in the areas of Science, Technology, Engineering, and Mathematics. Careful planning can be used to turn a job into a springboard for professional advancement and personal satisfaction. Topics to be addressed include setting priorities, understanding career ladders, making tough choices, overcoming stereotypes and assumptions by others, networking, developing a professional identify, and balancing a career with family and other personal responsibilities. Insights on the transition from individual technical work to leadership will also be provided. The author will draw upon experiences gained in academic, industrial, and government laboratory settings, as well as extensive professional service and community involvement.

  3. Aviation Career Awareness

    ERIC Educational Resources Information Center

    Journal of Aerospace Education, 1976

    1976-01-01

    Describes a kit containing seven units, each designed to increase the elementary school student's awareness of aviation and career possibilities in aviation. Includes a sample section from one unit. (MLH)

  4. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin.

    PubMed

    Ji, Hee Jung; Yeo, Hee Kyoung; Lee, Nam Hee; Hwang, Jung Suk; Koo, Kyung Ah; Cheong, Seon Woo; Park, Joo Hung; Oh, Gap Soo; Yoon, Chun Sik; Youn, Hyun Joo

    2005-02-01

    Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.

  5. Clinical careers film.

    PubMed

    2015-09-01

    Those interested in developing clinical academic careers might be interested in a short animated film by Health Education England (HEE) and the National Institute for Health Research. The three-minute film, a frame from which is shown below, describes the sort of opportunities that are on offer to all professionals as part of the HEE's clinical academic careers framework. You can view the film on YouTube at tinyurl.com/pelb95c.

  6. Initial Employment Report: Physics and Astronomy Degree Recipients of 2002 & 2003. AIP Report, Number R-282.25

    ERIC Educational Resources Information Center

    Langer, Casey; Mulvey, Patrick J.

    2005-01-01

    Physics and Astronomy Degree Recipients face a variety of career and educational choices once they receive their degree. The decisions that they make are affected by a wide range of influences, such as student experiences, evolving interests, family issues, personal finances, long-term career goals, and the economic conditions they encounter. This…

  7. SPIN-UP and Preparing Undergraduate Physics Majors for Careers in Industry

    NASA Astrophysics Data System (ADS)

    Howes, Ruth

    2011-03-01

    Seven years ago, the Strategic Programs for Innovations in Undergraduate Physics (SPIN-UP) Report produced by the National Task Force on Undergraduate Physics identified several key characteristics of thriving undergraduate physics departments including steps these departments had taken to prepare students better for careers in industry. Today statistical data from AIP shows that almost 40% of students graduating with a degree in physics seek employment as soon as they graduate. Successful undergraduate physics programs have taken steps to adapt their rigorous physics programs to ensure that graduating seniors have the skills they need to enter the industrial workplace as well as to go on to graduate school in physics. Typical strategies noted during a series of SPIN-UP workshops funded by a grant from NSF to APS, AAPT, and AIP include flexible curricula, early introduction of undergraduates to research techniques, revised laboratory experiences that provide students with skills they need to move directly into jobs, and increased emphasis on ``soft'' skills such as communication and team work. Despite significant success, undergraduate programs face continuing challenges in preparing students to work in industry, most significantly the fact that there is no job called ``physicist'' at the undergraduate level. supported by grant NSF DUE-0741560.

  8. Carolinas Energy Career Center

    SciTech Connect

    Classens, Anver; Hooper, Dick; Johnson, Bruce

    2013-03-31

    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  9. Australian academic primary health-care careers: a scoping survey.

    PubMed

    Barton, Christopher; Reeve, Joanne; Adams, Ann; McIntyre, Ellen

    2016-01-01

    This study was undertaken to provide a snapshot of the academic primary health-care workforce in Australia and to provide some insight into research capacity in academic primary health care following changes to funding for this sector. A convenience sample of individuals self-identifying as working within academic primary health care (n=405) completed an anonymous online survey. Respondents were identified from several academic primary health-care mailing lists. The survey explored workforce demographics, clarity of career pathways, career trajectories and enablers/barriers to 'getting in' and 'getting on'. A mix of early career (41%), mid-career (25%) and senior academics (35%) responded. Early career academics tended to be female and younger than mid-career and senior academics, who tended to be male and working in 'balanced' (teaching and research) roles and listing medicine as their disciplinary background. Almost three-quarters (74%) indicated career pathways were either 'completely' or 'somewhat unclear', irrespective of gender and disciplinary backgrounds. Just over half (51%) had a permanent position. Males were more likely to have permanent positions, as were those with a medical background. Less than half (43%) reported having a mentor, and of the 57% without a mentor, more than two-thirds (69%) would like one. These results suggest a lack of clarity in career paths, uncertainty in employment and a large number of temporary (contract) or casual positions represent barriers to sustainable careers in academic primary health care, especially for women who are from non-medicine backgrounds. Professional development or a mentoring program for primary health-care academics was desired and may address some of the issues identified by survey respondents.

  10. Career Assessment and the Adult Career Concerns Inventory.

    ERIC Educational Resources Information Center

    Cairo, Peter C.; And Others

    1996-01-01

    Describes the evolution of the Adult Career Concerns Inventory into an instrument that assesses adults' awareness of tasks associated with career adaptability. Practical applications and future research directions are discussed. (SK)

  11. Career Flow: A Hope-Centered Model of Career Development

    ERIC Educational Resources Information Center

    Niles, Spencer G.

    2011-01-01

    In this article, the author describes an innovative approach for conceptualizing and managing career development tasks in the 21st century. Theoretical foundations and key concepts related to career flow theory are discussed.

  12. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line

    PubMed Central

    Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip. PMID:27706259

  13. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.

    PubMed

    Fukuda, Takashi; Tanaka, Tomoko; Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip.

  14. Editor's Perspective Article: Alternative Certification Teachers--Strategies for the Transition to a New Career

    ERIC Educational Resources Information Center

    Evans, Brian R.

    2015-01-01

    New teachers who are prepared to teach through alternative certification pathways may find the transition to a new career stressful and tumultuous. There are techniques that can be used to help make the transition easier on new teachers as they begin their new careers. This article explores several strategies for new teachers, which include…

  15. The Unacknowledged Value of Female Academic Labour Power for Male Research Careers

    ERIC Educational Resources Information Center

    Angervall, Petra; Beach, Dennis; Gustafsson, Jan

    2015-01-01

    Academic work in Sweden's higher education system is changing character. Distinctly different career pathways are emerging, as facilities for developing research careers and capital have become both more restricted and more dependent on external funding. These developments are in focus in the present article. Based on ethnographic research and a…

  16. Career Adaptability: A Qualitative Understanding from the Stories of Older Women

    ERIC Educational Resources Information Center

    McMahon, Mary; Watson, Mark; Bimrose, Jenny

    2012-01-01

    This article reports on an international qualitative study investigating career pathways through the stories of transition and adaptability of older women. Informed by grounded theory, the study explored how this group of women coped with and adapted to changes and transitions related to career. Data were gathered by means of interviews with 36…

  17. Integrative Life Planning. Critical Tasks for Career Development and Changing Life Patterns.

    ERIC Educational Resources Information Center

    Hansen, L. Sunny

    This book presents an integrative life planning (ILP) model for career professionals/counselors to use in helping their clients develop career and life pathways responsive to their own economic, family, spiritual, and cultural needs and also to community needs. Discussed in chapters 1-2, which introduce the ILP model as a new way of thinking about…

  18. Envisioning a Career in Science, Technology, Engineering and Mathematics: Some Challenges and Possibilities

    ERIC Educational Resources Information Center

    Sharkawy, Azza

    2015-01-01

    In "How High School Students Envision Their STEM Career Pathways", Lin Zhang and Michael Barnett attempt to shed light on the problem of underrepresented students (e.g., Aboriginals, Hispanics, African Americans, urban, females) in STEM higher education and related careers by exploring, in general terms, five high school students' career…

  19. Female Elementary Principals' Perceptions about Access to Potential Career Routes to the Superintendency in Pennsylvania

    ERIC Educational Resources Information Center

    Polinchock, Jennifer Anne

    2014-01-01

    A variety of factors contribute to women's underrepresentation in educational administration, particularly in positions that traditionally lead to the superintendency. This study examines the career pathways of female superintendent aspirants from the elementary principalship. A conceptual framework based on career development and motivation…

  20. Racial/Ethnic and Gender Equity Patterns in Illinois High School Career and Technical Education Coursework

    ERIC Educational Resources Information Center

    Hamilton, Asia Fuller; Malin, Joel; Hackmann, Donald

    2015-01-01

    This study analyzed high school Career and Technical Education (CTE) enrollments in Illinois, with comparisons to national data when possible, by career cluster and pathway and with respect to gender and racial/ethnic makeup of students. Enrollment patterns in Science, Technology, Engineering, and Math (STEM) CTE programming were emphasized.…

  1. Transitioning to the Classroom: Reflections of Second-Career Teachers during the Induction Year

    ERIC Educational Resources Information Center

    Brindley, Roger; Parker, Audra

    2010-01-01

    In recent years teacher educators have witnessed an increase in the number of alternative pathways to university-based teacher education for prospective teachers. One option is for second-career teachers to enter post-baccalaureate programs in education; however, the experiences of second-career teachers are largely unexplored in the international…

  2. Career Education and Organized Labor. Monographs on Career Education.

    ERIC Educational Resources Information Center

    Hoyt, Kenneth B.; And Others

    The three papers compiled here provide educators and others involved in career education with some information regarding the relationship of career education and organized labor. The first paper, a conference speech by Peter A. Bommarito, President of the United Rubber Workers, presents an official policy statement on career education from the…

  3. Ohio's Career Development Blueprint. Individual Career Plan, Middle School.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational and Career Education.

    This publication provides materials to assist in the individual career plan (ICP) process in grades 6-8. Suggestions are made related to career planning teams. Focus is on 12 key topics, all necessary for a middle-grade student to consider before developing an ICP. The topics are self awareness; self assessment; career information; exploration;…

  4. Ohio's Career Development Blueprint. Individual Career Plan, K thru 5.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational and Career Education.

    This publication provides materials to assist in Ohio's individual career plan (ICP) process in grades K-5. Suggestions are made related to delivery and role of a career development liaison. Focus is on 12 key topics: self awareness; self assessment; career information; exploration; academic planning; reduction of bias; future trends;…

  5. Ohio's Career Development Blueprint. Individual Career Plan, High School.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational and Career Education.

    This publication offers guidance on how to provide high school students who have developed an individual career plan (ICP) in Grade 8 with additional opportunities to explore and verify their educational and career goals and to formally review, revise, and add to their ICP document annually. Suggestions are made related to career planning teams.…

  6. Super's Career Stages and the Decision to Change Careers.

    ERIC Educational Resources Information Center

    Smart, Roslyn; Peterson, Candida

    1997-01-01

    Australians (n=226) in one of four stages of a second career (contemplating, choosing a field, implementing, change completed) were compared with 81 nonchangers. Job satisfaction varied as a function of stage. Results supported Super's theory that career changers cycle through the full set of career stages a second time. (SK)

  7. Career Development in the Schools. Issues in Career Development

    ERIC Educational Resources Information Center

    Eliason, Grafton T., Ed.; Patrick, John, Ed.

    2008-01-01

    "Career Development in the Schools" describes a dynamic process that continues to evolve in its rationale and practice. In many schools and in a variety of scholarly writings, the status of career development is controversial. Some observers assert that career development should be seen as a by-product of all of the knowledge and activities that…

  8. Career Practitioners' Conceptions of Social Media in Career Services

    ERIC Educational Resources Information Center

    Kettunen, Jaana; Vuorinen, Raimo; Sampson, James P., Jr.

    2013-01-01

    This article reports the outcomes of a study, undertaken from a phenomenographic perspective, of career practitioners' conceptions of social media usage in career services. Fifteen Finnish career practitioners--representing comprehensive, secondary and higher education as well as public employment services--were interviewed in focus groups. The…

  9. Coping with Career Indecision: Differences between Four Career Choice Types

    ERIC Educational Resources Information Center

    Lee, Ki-Hak

    2005-01-01

    This study examined the applicability of Gianakos' [1999. Journal of Vocational Behavior, 54, 244-258] typology of career choice--stable, conventional, multiple-trial and unstable--to emotional coping with career indecision. Three hundred-twenty (Men = 203, Women = 117) Korean undergraduates were classified into Gianakos' four career choice types.…

  10. Reducing Adolescent Career Indecision: The ASVAB Career Exploration Program.

    ERIC Educational Resources Information Center

    Baker, Harley E.

    2002-01-01

    Presents a study that evaluated the Armed Services Vocational Aptitude Battery (ASVAB) Career Exploration Program using nationally representative samples of high school students. Results showed that participation in the ASVAB Program increased career exploration knowledge and reduced forms of career indecision. (Contains 25 references and 1…

  11. Effects of Career Choice Intervention on Components of Career Preparation

    ERIC Educational Resources Information Center

    Koivisto, Petri; Vinokur, Amiram D.; Vuori, Jukka

    2011-01-01

    This randomized experimental study (N = 1,034) examines both the direct and the indirect effects of the Towards Working Life intervention on 2 components of adolescents' career preparation: preparedness for career choice and attitude toward career planning. The intervention comprised a 1-week workshop program, the proximal goals of which were to…

  12. Career Transitions in Turbulent Times: Exploring Work, Learning and Careers.

    ERIC Educational Resources Information Center

    Feller, Rich, Ed.; Walz, Garry R., Ed.

    A collection of 47 articles, this monograph addresses critical needs and promising practices in career development. The articles, written both by leaders and new comers in career development, offer extensive scholarship and new perspectives. The volume is divided into six sections: (1) Foundations Revisited; (2) Turbulence in Career Development:…

  13. Career Goals and Career Management Strategy among Information Technology Professionals.

    ERIC Educational Resources Information Center

    Lee, Patrick Chang Boon

    2002-01-01

    Responses from 309 of 2,000 information technology professionals showed the aspirations of the majority were in traditional managerial or technical career paths. A growing number aspire to technoentrepreneurship. The ability to plan and strategize their own careers was an important factor in career satisfaction. (29 references) (SK)

  14. A Career in Inquiry

    PubMed Central

    2015-01-01

    This article, based on the 52nd Eleanor Clarke Slagle lecture given at the 95th American Occupational Therapy Association Annual Conference & Expo, explores the concept of inquiry as the basis for a career and as an activity of daily living. Using the heliocentric theory and the space program at NASA as examples, the broad concept of inquiry is discussed, because it has led to important changes in society over the course of history. The article describes how a career as a clinician–scientist can be grounded in the concept of inquiry and explains how all occupational therapists and occupational therapy assistants can base their own careers in inquiry, using examples from the early history of the profession of occupational therapy and from work by current investigators. Practical suggestions applicable to every clinician are provided. PMID:26565091

  15. A Career in Nuclear Energy

    ScienceCinema

    Lambregts, Marsha

    2016-07-12

    Nuclear chemist Dr. Marsha Lambregts talks about the Center for Advanced Energy Studies and the benefits of a nuclear energy career. For more information about careers at INL, visit http://www.facebook.com/idahonationallaboratory.

  16. Career Education: A Brief Overview.

    ERIC Educational Resources Information Center

    Kokaska, Charles J.

    1983-01-01

    Career education, which is designed to promote cognitive, affective, and psychomotor skills at all educational levels, is especially important for exceptional children. A comprehensive approach to career development is needed by school districts, along with feedback from former students. (SEW)

  17. A Career in Nuclear Energy

    SciTech Connect

    Lambregts, Marsha

    2009-01-01

    Nuclear chemist Dr. Marsha Lambregts talks about the Center for Advanced Energy Studies and the benefits of a nuclear energy career. For more information about careers at INL, visit http://www.facebook.com/idahonationallaboratory.

  18. Career Management: Whose Responsibility? Second Edition.

    ERIC Educational Resources Information Center

    Stevens, Paul

    All employees are influenced by career management actions at each step of their career. The responsibility for career planning rests with the individual, whereas the responsibility for career development support should be the employer's: career management is a shared decision. Career planning training helps employees to analyze their interests and…

  19. Career planning resources

    NASA Astrophysics Data System (ADS)

    To Boldly Go: A Practical Career Guide for Scientists, written by Peter S. Fiske and published by AGU, is aimed at professionals and students considering nonacademic careers. Beginning with an assessment of the current job situation in academia, this book examines other opportunities in science, shows how to explore possibilities, and diagrams job search strategies. Outlines and samples illustrate clear and effective curriculum vitae, resumes, and cover letters. For more information, see http://www.agu.org/careerguide; call 1-800-966-2481 in North America to order; elsewhere, call 202-462-6900. The price for AGU members is 13.30 per copy, 19.00 for nonmembers.

  20. Overconfidence and Career Choice

    PubMed Central

    Schulz, Jonathan F.; Thöni, Christian

    2016-01-01

    People self-assess their relative ability when making career choices. Thus, confidence in their own abilities is likely an important factor for selection into various career paths. In a sample of 711 first-year students we examine whether there are systematic differences in confidence levels across fields of study. We find that our experimental confidence measures significantly vary between fields of study: While students in business related academic disciplines (Political Science, Law, Economics, and Business Administration) exhibit the highest confidence levels, students of Humanities range at the other end of the scale. This may have important implications for subsequent earnings and professions students select themselves in. PMID:26808273

  1. Overconfidence and Career Choice.

    PubMed

    Schulz, Jonathan F; Thöni, Christian

    2016-01-01

    People self-assess their relative ability when making career choices. Thus, confidence in their own abilities is likely an important factor for selection into various career paths. In a sample of 711 first-year students we examine whether there are systematic differences in confidence levels across fields of study. We find that our experimental confidence measures significantly vary between fields of study: While students in business related academic disciplines (Political Science, Law, Economics, and Business Administration) exhibit the highest confidence levels, students of Humanities range at the other end of the scale. This may have important implications for subsequent earnings and professions students select themselves in.

  2. Wind Power Career Chat

    SciTech Connect

    Not Available

    2011-01-01

    This document will teach students about careers in the wind energy industry. Wind energy, both land-based and offshore, is expected to provide thousands of new jobs in the next several decades. Wind energy companies are growing rapidly to meet America's demand for clean, renewable, and domestic energy. These companies need skilled professionals. Wind power careers will require educated people from a variety of areas. Trained and qualified workers manufacture, construct, operate, and manage wind energy facilities. The nation will also need skilled researchers, scientists, and engineers to plan and develop the next generation of wind energy technologies.

  3. Key Decision Points in the Careers of Geoscientists: The Role of the YES Network in Facilitating Successful Career Transitions for Early Career Geoscientists (Invited)

    NASA Astrophysics Data System (ADS)

    Venus, J. H.; Gonzales, L. M.; Yes Network

    2010-12-01

    The external influences on the decisions that geoscientists make pertaining to their careers are often assumed but not quantified. The YES Network is conducting an international study to determine the Key Decision points in the career pathways of early career geoscientists. The study aims to identify factors contributing to individual career decisions and to monitor these over a ten year period. The Initial phase of the study is now underway enabling preliminary conclusions to be drawn and will identify a group of individuals that will be tracked over the 10 year programme. The Survey will highlight reoccurring areas where Early Career Geoscientists are experiencing progression difficulties and, importantly, provide respondents with an opportunity to suggest solutions whilst also allowing general resource needs to be identified from the results as a whole. Early results show an overwhelming majority expressing job satisfaction most or all of the time (only 2 candidates reporting none). Respondents rate job satisfaction and respect highly, returning more responses than good salaries. A general frustration with administration, paper work and bureaucracy is particularly evident in those employed by government organisations. Early Career geoscientists express a frustration concerning a lack of involvement in decision making processes; interestingly several later career respondents also acknowledge a need to properly train, nurture and encourage new recruits to retain good graduates who may otherwise become disillusioned and leave the profession. The role of family in career choices has been highlighted both in survey and general feedback responses particularly by female geoscientists and those working in jobs with high levels of fieldwork; we aim to determine, to some extent, to what point these decisions are controlled by family as opposed to normal career progression. Flexible working conditions and agreed time away from field duty have been independently suggested

  4. Career Education for Elementary Grades.

    ERIC Educational Resources Information Center

    Dianna, Michael A.

    Information and activities are provided to help elementary school teachers develop a career education "environment" for children. Ten basic premises of career education are outlined, and the key ideas and terms that emerge from the premises are defined. The eight goals of career education are set forth to provide the teacher with a base from which…

  5. Southeast Asian Career Exploration Program.

    ERIC Educational Resources Information Center

    Podolske, Mel

    This set of competency-based learning modules consists of four career exploration modules and three science modules for use with adults with limited English proficiency. The four career exploration models contain activities designed to introduce students to career opportunities and basic job skills and safety procedures in the following fields:…

  6. Career Transitions: The Australian Experience.

    ERIC Educational Resources Information Center

    Stevens, Paul

    This book is designed to aid career counselors in Australia help their clients search for enhanced well-being in their occupations and to help organizations and human resource staff members dealing with employees' career development. The book is organized in four parts. Parts 1 and 2 explore the career transition journey that a typical person…

  7. Career Development in Rural Education.

    ERIC Educational Resources Information Center

    Baskerville, Roger A.

    The Lohrville Career Education Model (LCEM) was instituted as a systematic attempt at exploring careers in Iowa and inducing Iowa youth to seek careers closer to home following high school graduation or post-secondary education training; a major purpose of the Toward Community Growth project was to teach positive attitudes about living and working…

  8. The Individual Career Plan Handbook.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Vocational Instructional Materials Lab.

    This guide explains the purpose and use of the Individual Career Plan (ICP) document as a tool that students can use from the middle grades onward to help them through the career planning process. Section 1, which provides a rationale for ICPs, examines their role in the career development process and use in the middle grades and high school.…

  9. Internship Handbook for Career Academies.

    ERIC Educational Resources Information Center

    Winthrop, Jerauld

    Career academies are high school programs that frame academic learning around a career focus in order to increase student motivation and achievement. They generally have three defining features: a school-within-a-school structure, a college preparation curriculum with a career theme, and partnerships with employers, the community, and higher…

  10. Effective Career Exploration Programs Revisited.

    ERIC Educational Resources Information Center

    Wiggins, James D.

    1987-01-01

    Replicated findings of Wiggins and Moody (1981). Evaluated four types of high school career exploration programs: cluster (N=53), Career Maturity Inventory (N=52), Career Survey (N=57), and Self-Directed Search/Vocational Preference Inventory (N=55). Results favored latter three programs which allowed students to pursue their own interests instead…

  11. Predictability of Expressed Career Intent.

    ERIC Educational Resources Information Center

    Shenk, Faye

    An historical study of officer input from the various Air Force commissioning programs was initiated in 1963. The study was designed to determine the predictability of an Air Force officer's career decision and to evaluate relationships between career intent and demographic, environmental, and attitudinal factors. Career-intention information for…

  12. Classifying Korean Adolescents' Career Preparedness

    ERIC Educational Resources Information Center

    Lee, In Heok; Rojewski, Jay W.; Hill, Roger B.

    2013-01-01

    Latent class analysis was used to examine the career preparation of 5,227 11th-grade Korean adolescents taken from the Korean Education Longitudinal Study of 2005 (KELS:2005). Three career preparedness groups were identified, to reflecting Skorikov's ("J Vocat Behav" 70:8-24, 2007) conceptualization of career preparedness: prepared,…

  13. Expanding Career Awareness with CIPS.

    ERIC Educational Resources Information Center

    Patterson, John

    Career Information Packets is an individually oriented career exploration program developed for high school students. The program goals are to: (1) assist students in becoming aware of their patterns, of values, interests and aptitudes in relation to the world of work; (2) to assist students in making tentative career choices; and (3) assist them…

  14. Career-Tech Time Machine

    ERIC Educational Resources Information Center

    Monberg, Greg; Bannourah, Riyad

    2011-01-01

    In the 1940s, 50s, and 60s, the skills needed to have a successful career were very different than they are today. This case study of the Hammond Area Career Center's Multimedia Broadcast Academy shows how one Rust Belt community has revamped its approach to career and technical education and is preparing students for jobs in the new economy. This…

  15. Mid-Life Career Change.

    ERIC Educational Resources Information Center

    Bramson, Leon; Kohn, Lisa

    This report deals primarily with the literature involving mid-career changes within the paid labor force. Changes from unpaid to paid employment and the career shift of the housewife who joins or rejoins the labor force are considered, but shifts to unpaid work, volunteer jobs, and early retirement without a second career are not included. The…

  16. Black Agenda for Career Education.

    ERIC Educational Resources Information Center

    Johnson, Roosevelt

    This 12-chapter book contains contributions from selected authors concentrating on a comprehensive analysis of career education for the black American. The treatise takes career education to task for its "white foundations of educational data." Chapter titles and authors are: Black Agenda for Career Education, by Roosevelt Johnson; Career…

  17. Career as a Developmental Concept.

    ERIC Educational Resources Information Center

    Paulig, Kristin

    Sociological literature on careers reveals that there are four major approaches framing career study, i.e., developmental, objective-empirical, normative, and interactive perspectives. Analysis of these approaches points to an orienting conceptualization of career based on the core characteristics of centrality, duration, and public…

  18. Careers in Law Enforcement.

    ERIC Educational Resources Information Center

    Herbert, Solomon J.

    1991-01-01

    Opportunities for blacks in law enforcement careers are detailed. Local and federal law enforcement agencies are hiring members of minority groups. In a climate in which so many young African Americans are involved in negative behaviors, others should take the opportunity to try to provide positive role models. (SLD)

  19. College and Career Readiness

    ERIC Educational Resources Information Center

    ICF International (NJ1), 2012

    2012-01-01

    Graduating high school students must be adequately prepared to enter post-secondary training or employment, without the need for remediation, in order to take their places as independent adults and informed citizens. College and career readiness has taken the forefront of national and state education policy. ICF's information brief on college and…

  20. A Career that Fits

    ERIC Educational Resources Information Center

    Griffin, Shari Chaney; Newsome, Brian

    2007-01-01

    With a firm belief that "no student deserves to be a number," Jill Martin, the 2007 National Association of Secondary School Principals (NASSP) MetLife High School Principal of the Year, has built her career on a commitment to giving every student a high quality education and a good start in life. With a degree in English and a craving…

  1. Metrics in Career Education.

    ERIC Educational Resources Information Center

    Lindbeck, John R.

    The United States is rapidly becoming a metric nation. Industry, education, business, and government are all studying the issue of metrication to learn how they can prepare for it. The book is designed to help teachers and students in career education programs learn something about metrics. Presented in an easily understood manner, the textbook's…

  2. Careers in biomedical engineering.

    PubMed

    Madrid, R E; Rotger, V I; Herrera, M C

    2010-01-01

    Although biomedical engineering was started in Argentina about 35 years ago, it has had a sustained growth for the last 25 years in human resources, with the emergence of new undergraduate and postgraduate careers, as well as in research, knowledge, technological development, and health care.

  3. Career Update: Moving Up.

    ERIC Educational Resources Information Center

    Thomas, Irene Middleman

    1992-01-01

    Discusses corporate hiring and promotion of Hispanic Americans. Interview respondents discuss their Hispanic backgrounds, education, and corporate practices that helped advance their careers. Subjects include executives at SmithKline Beecham (Philadelphia), IBM, John F. Kennedy School of Government (Harvard), Aetna Life and Casualty, and Chase…

  4. Career Education, Grade 6.

    ERIC Educational Resources Information Center

    Syracuse City School District, NY.

    Part of the Syracuse (New York) city school district's guided occupational orientation program, the student workbook consists of information and question sheets suitable for grade 6 career education studies on topics in the labor field, including labor laws, wages, and unions; job applications and interviews; on-the-job training; and social…

  5. Career Counseling Resources.

    ERIC Educational Resources Information Center

    Roy, Loriene, Ed.

    Part of a larger report on the Four Directions Project, an American Indian technology innovation project, this section includes six "pathfinders" to locating information on college preparation and career planning. The pathfinders were designed by students in the Graduate School of Library and Information Science at the University of Texas at…

  6. The Retirement Career.

    ERIC Educational Resources Information Center

    Kreitlow, Burton; Kreitlow, Doris

    A study examined 140 persons from nine very diverse settings in the United States and England who had retired in a positive way. Interviews with the retirees revealed that despite their diverse geographical, socioeconomic, and racial/ethnic backgrounds, they all had one thing in common--in retirement, all of them had a new and exciting career.…

  7. Careers in Dance.

    ERIC Educational Resources Information Center

    Weeks, Sandra

    Trends in the current job market in the field of dance are identified, and aspects, such as personal qualifications, training requirements, income potential, and employment possibilities, are discussed. Employment opportunities in the professional world, the field of education, and the corporate environment are explored. Career opportunities for…

  8. Career Development in Germany.

    ERIC Educational Resources Information Center

    Hass, Hubert

    In Germany, after elementary school, the school system splits into three branches, with students either preparing for an apprenticeship or continuing in school. A second system exists, parallel to this education system, which combines general education with basic professional training. The first key career decision point is in Grade 4, when…

  9. Careers in Airway Science.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    The Federal Aviation Administration (FAA) has initiated the Airway Science curriculum as a method of preparing the next generation of aviation technicians and managers. This document: (1) discusses the FAA's role in the Airway Science program; (2) describes some of the career fields that FAA offers to Airway Science graduates (air traffic control…

  10. Assessing Children's Career Aspirations

    ERIC Educational Resources Information Center

    Plummer, Donna M.

    2008-01-01

    In the past several years, "Science and Children" has invited preservice and inservice teachers to participate in national studies of students' ideas about scientists (Barman 1997), animals (Barman et al. 2000), and plants (Barman et al. 2003). You are invited to participate in an additional study that will examine children's career aspirations.…

  11. Midwifery. An international career.

    PubMed

    Vansintejan, G A

    1989-01-01

    International work is an unforgettable experience that promotes personal growth and fosters adaptability to any professional environment thereafter. The author describes highlights of her own professional career with the hope of encouraging others to undertake midwifery service in less developed countries.

  12. My Career: Composer

    ERIC Educational Resources Information Center

    Morganelli, Patrick

    2013-01-01

    In this article, the author talks about his career as a composer and offers some advice for aspiring composers. The author works as a composer in the movie industry, creating music that supports a film's story. Other composers work on television shows, and some do both television and film. The composer uses music to tell the audience what kind of…

  13. Career Development in Australia.

    ERIC Educational Resources Information Center

    McCowan, Colin; Mountain, Elizabeth

    Australia has a federal system, comprising the national Commonwealth government and eight state and territory governments. At the Commonwealth level, the ministries of Education, Training and Youth Affairs, and Employment, Workplace Relations and Small Business have primary roles in the career information and services field. Education and training…

  14. A Certified Health Career

    ERIC Educational Resources Information Center

    Adamson, Pamela

    2006-01-01

    This article features a certification program for health care workers in Southeastern Oklahoma. Kiamichi Technology Center is certifying success for its students while helping to meet the demand for trained health care workers in Southeastern Oklahoma. Through the health careers certification program at Kiamichi Technology Center in Hugo, Oklahoma…

  15. Quality in Careers Guidance.

    ERIC Educational Resources Information Center

    Plant, Peter

    This paper examines quality issues in career guidance, counseling, and information services in Europe and elsewhere from a range of different perspectives related to economic, ethical, and/or effectiveness criteria. Selected examples from the European Union member states, Canada, and the United States are used to illustrate how quality is…

  16. Learning About Space Careers.

    ERIC Educational Resources Information Center

    Peters, Herman J.; And Others

    This book which is intended for children in grades 4 through 6 includes information concerning the space industry and career opportunities. Included are five separate chapters, a summary, and a bibliography of children's books. The book describes a sequence of events taking place in a hypothetical elementary school classroom in which a space…

  17. Career Adaptability in Childhood

    ERIC Educational Resources Information Center

    Hartung, Paul J.; Porfeli, Erik J.; Vondracek, Fred W.

    2008-01-01

    Childhood marks the dawn of vocational development, involving developmental tasks, transitions, and change. Children must acquire the rudiments of career adaptability to envision a future, make educational and vocational decisions, explore self and occupations, and problem solve. The authors situate child vocational development within human life…

  18. Exploring Careers through Volunteerism.

    ERIC Educational Resources Information Center

    Beale, Andrew V.

    1984-01-01

    Discusses a four-session workshop which helps middle school students realize the value of volunteerism for career exploration and skill development. Describes how to find a volunteer job, how to apply, guidelines for successful volunteering, and documenting volunteer experiences. (JAC)

  19. Careers in Environmental Protection.

    ERIC Educational Resources Information Center

    Millard, Reed

    The book presents concerns of our society in protecting our environment and the challenges involved in meaningful careers in environmental protection and management. "Estimates by the Environmental Protection Agency indicate that, compared with their numbers in the mid-'70's, the need for environmental professionals will triple by…

  20. Career Awareness through Textiles.

    ERIC Educational Resources Information Center

    Domalski, Beverly

    This collection of art units is intended to be incorporated into the curriculum throughout the career motivation program, kindergarten through grade six. The units use simulated classroom art projects to provide students with exposure to the work done in textile decoration. General information about the textile industry and textile decoration, a…

  1. Careers in Music.

    ERIC Educational Resources Information Center

    Music Educators National Conference, Reston, VA.

    A report on music-related careers is divided into two sections. Section 1 provides summaries of occupations, including studio teaching, elementary-secondary education, postsecondary teaching, performance, composing and directing, the music industry (including the fields of instrument manufacturing, tuning, radio broadcasting, and recording), music…

  2. Developing a Career Center.

    ERIC Educational Resources Information Center

    Feller, Rich, Ed.

    This 12-section handbook, based on information for Colorado but applicable to other states as well, contains resources and lists and explains procedures to establish or expand a career guidance center in a school, government office, or organization. The 12 sections cover the following topics: (1) purpose and philosophy; (2) assessment, advisory…

  3. Science Career Magazine.

    ERIC Educational Resources Information Center

    Halsey, Linda B., Ed.; Sweeley, Charles C., Ed.

    This magazine is designed for teachers and students in junior and senior high schools. It is intended to help students become more aware about what scientists and engineers do, what's new and exciting in the fields of science and engineering, and what satisfactions might be expected from a career in one of the many different areas of science and…

  4. Career Paths and Career Success in the Early Career Stages of Male and Female MBAs.

    ERIC Educational Resources Information Center

    Cox, Taylor H.; Harquail, Celia V.

    1991-01-01

    Data from 125 females and 377 males (40 percent response) in managerial careers indicated that women had similar total promotions and career satisfaction but lower salary increases, fewer management promotions, and lower hierarchical levels. Starting salaries and job levels, job mobility, line experience, and seniority affected career success. (SK)

  5. Career Orientations and Career Cultures: Individual and Organisational Approaches to Beginning Teachers' Careers

    ERIC Educational Resources Information Center

    Coldwell, Mike

    2016-01-01

    Despite the very large literature on teacher careers from an individual perspective, there is relatively little that links the perspectives of teachers themselves to how schools as organisations approach careers. The aim of this paper is, first, to outline how teachers' orientations towards careers change across three dimensions, and, second, to…

  6. Capturing Career Reflections: Construction of an Instrument to Explore Careers and Career Development

    ERIC Educational Resources Information Center

    McDonald, Kimberly S.; Hite, Linda M.; Mansour-Cole, Dina

    2006-01-01

    This study describes the development and validation of an instrument to tap employee reflections on career interests, needs and career development opportunities. Item construction was based on issues identified in previous qualitative research and themes prevalent in recent HRD career development literature. Pilot data for an exploratory factor…

  7. Internship Prepares Students for Careers in Early Childhood Education

    ERIC Educational Resources Information Center

    Cifelli, Sylvia R.

    2007-01-01

    "Pathways to Success" is the internship component of the school-to-career Child Care program at Joseph Case High School in Swansea, Massachusetts. Its primary purpose is to prepare high school seniors for future education and employment. Through involvement in this 24-week internship, family and consumer sciences (FCS) students gain a…

  8. Learning Workers: Young New Zealanders and Early Career Development

    ERIC Educational Resources Information Center

    Vaughan, Karen

    2010-01-01

    Young adults' early career development is an increasingly important field of inquiry. With the complexity of modern transitions from school and the lifelong learning demands of emerging knowledge societies, governments are concerned to improve learning pathways into, and through, tertiary education and work. Young adults are exploring new learning…

  9. Envisioning a career in science, technology, engineering and mathematics: some challenges and possibilities

    NASA Astrophysics Data System (ADS)

    Sharkawy, Azza

    2015-09-01

    In How High School Students Envision Their STEM Career Pathways, Lin Zhang and Michael Barnett attempt to shed light on the problem of underrepresented students (e.g., Aboriginals, Hispanics, African Americans, urban, females) in STEM higher education and related careers by exploring, in general terms, five high school students' career visions and the experiences that influenced their career visions. In this paper, I attempt to extend the authors' discussions on the underrepresentation of minority students in STEM higher education by highlighting some of the factors that begin to influence youths' career decisions long before they reach the high school level and are required to make specific career choices. I also draw on Glen Aikenhead's Sci Edu, 27, 1-52 (1996) notion of border crossing and research by Victoria Costa Sci Edu, 79, 313-333 (on the significance of the relationship between students' cultural worlds and the cultural world of school science.

  10. The Effects of Mandated Career and Technical Education (CTE) on the College and Career Preparation of High School Students

    ERIC Educational Resources Information Center

    Hagen, Stephen N.

    2010-01-01

    College and career readiness offers a distinct purpose to the high school experience. This experience must provide a variety of options with a clear focus on fruitful opportunities for success. Meaningful citizenship in any learning community demands that all students participate in a pathway of sequenced, practical, related classes and achieve…

  11. Multiple Pathways for All Students

    ERIC Educational Resources Information Center

    Stirling, Lee Anna

    2012-01-01

    Maine has been focusing on the importance of postsecondary training. Maine's Skowhegan Area High School (SAHS) and Somerset Career and Technical Center (SCTC) have partnered in a Multiple Pathways initiative (funded by the Nellie Mae Education Foundation) to increase students' high school completion rate and to increase enrollment in postsecondary…

  12. The Roles of Negative Career Thinking and Career Problem-Solving Self-Efficacy in Career Exploratory Behavior

    ERIC Educational Resources Information Center

    Bullock-Yowell, Emily; Katz, Sheba P.; Reardon, Robert C.; Peterson, Gary W.

    2012-01-01

    The respective roles of social cognitive career theory and cognitive information processing in career exploratory behavior were analyzed. A verified path model shows cognitive information processing theory's negative career thoughts inversely predict social cognitive career theory's career problem-solving self-efficacy, which predicts career…

  13. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.

    PubMed

    Bian, Hui; Yu, Long-Chuan

    2015-07-10

    Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine- dependent protein kinase, which has been implicated in pain modulation at different levels of the central nervous system. The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 3 μg, 6 μg and 12 μg of myristoylated autocamtide-2-inhibitory peptide (AIP), the CaMKII inhibitor, dose-dependently increased the HWL to noxious thermal and mechanical stimulation in rats with mononeuropathy. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and AIP group. Taken together, the results showed that intra-NAc injection of AIP induced significant antinociceptive effects in rats with mononeuropathy, indicating that CaMKII may play an important role in the transmission and/or modulation of nociceptive information in the NAc in rats with mononeuropathy.

  14. Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

    PubMed

    Nord, Karolin H; Magnusson, Linda; Isaksson, Margareth; Nilsson, Jenny; Lilljebjörn, Henrik; Domanski, Henryk A; Kindblom, Lars-Gunnar; Mandahl, Nils; Mertens, Fredrik

    2010-12-07

    Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary adenoma predisposition and multiple endocrine neoplasia type I. MEN1 and AIP displayed a low expression in hibernomas whereas the expression of genes up-regulated in brown fat--PPARA, PPARG, PPARGC1A, and UCP1--was high. Thus, loss of MEN1 and AIP is likely to be pathogenetically essential for hibernoma development. Simultaneous loss of two tumor suppressor genes has not previously been shown to result from a neoplasia-associated translocation. Furthermore, in contrast to the prevailing assumption that benign tumors harbor relatively few genetic aberrations, the present analyses demonstrate that a considerable number of chromosome breaks are involved in the pathogenesis of hibernoma.

  15. Careers and people

    NASA Astrophysics Data System (ADS)

    2009-02-01

    Early-career scientists honoured Nine physicists were among 67 US-based researchers to be awarded a Presidential Early Career Award for Scientists and Engineers at a White House ceremony in late December 2008. The award comes with up to five years' funding for research deemed critical to government missions. This year's winners include nuclear physicist Mickey Chiu and particle physicist Hooman Davoudiasl, both of the Brookhaven National Laboratory; biophysicist Michael Elowitz of the California Institute of Technology; Chad Fertig, an atomic physicist at the University of Georgia; astronomer Charles Kankelborg of Montana State University; astrophysicist Merav Opher of George Mason University; theorist Robin Santra of the Argonne National Laboratory; quantum-computing researcher Raymond Simmons of the National Institute of Standards and Technologies in Boulder, Colorado; and string theorist Anastasia Volovich of Brown University.

  16. Recommendations from the Italian Interdisciplinary Working Group (AIMN, AIP, SINDEM) for the utilization of amyloid imaging in clinical practice.

    PubMed

    Guerra, Ugo Paolo; Nobili, Flavio Mariano; Padovani, Alessandro; Perani, Daniela; Pupi, Alberto; Sorbi, Sandro; Trabucchi, Marco

    2015-06-01

    Positron emission tomography (PET) of brain amyloid is a technology that has been approved by Food and Drug Administration and European Medical Agency, but its clinical utility in medical practice requires careful definition. To provide guidance to italian dementia care practitioners, patients, and caregivers, a group of experts from "Associazione Italiana di Medicina Nucleare" (AIMN), "Associazione Italiana di Psicogeriatria" (AIP) and "Società Italiana per lo Studio delle Demenze" (SINDEM) convened the Italian Interdisciplinary Working Group on Amyloid Imaging. The Working Group considered a range of clinical scenarios in which amyloid PET should be recommended. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these recommendations. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific recommended use criteria were agreed to define the types of patients and clinical circumstances in which amyloid PET could be used. Both correct and incorrect uses were considered and formulated. Because both dementia care and amyloid-PET technology are in active development, these recommendations will require periodic reassessment.

  17. WE-H-204-02: Part 1: History and Archives Resources at AIP for AAPM and Its Members.

    PubMed

    Good, G

    2016-06-01

    basic X-ray tube used today in medicine, research and industry. In 1932 Coolidge became Director of the GE Laboratory, then in 1940 Vice-President and Director of Research. In 1941 he was a member of a small committee, appointed by President Franklin D. Roosevelt, to evaluate the military importance of research on uranium. This committee's report led to the establishment of the Manhattan Engineering District for nuclear weapons development during WWII. Coolidge lived to be over 100 years old, he had 83 patents to his credit, numerous awards and honorary degrees, and in 1975 was elected to the National Inventor's Hall of Fame. At the time he was the only inventor to receive this honor in his lifetime. Dr. Coolidge was also the first recipient of the AAPM's highest science award - named in his honor. From notes of a day-long interview with Coolidge's son Lawrence in the mid-1990s, previous biographies, publications, books, GE literature, historic photographs, e.g., a wonderful 1874 photo stereoview card with 1 year old baby "Willie Coolidge", and other artifacts in the author's collection, this presentation will review Dr. Coolidge's amazing life, work, accomplishments and awards. "History and Archives Resources at AIP for AAPM and its Members" Gregory A. Good, Ph.D. - Director, AIP Center for History of Physics Melanie J. Mueller, MLIS - Acting Director, AIP Niels Bohr Library & Archives The American Institute of Physics established the Center for History of Physics and the Niels Bohr Library & Archives in the 1960s. Our shared mission is: To preserve and make known the history of the physical sciences. This talk will explore the many ways that AIP's two history programs support the historical and archival activities of AAPM. Topics will include our ongoing oral history program, web outreach through exhibits and teaching guides, and archiving for AAPM and other Member Societies. We will focus in particular on materials in our collections related to the history of medical

  18. WE-H-204-03: Part 2: History and Archives Resources at AIP for AAPM and Its Members.

    PubMed

    Mueller, M

    2016-06-01

    basic X-ray tube used today in medicine, research and industry. In 1932 Coolidge became Director of the GE Laboratory, then in 1940 Vice-President and Director of Research. In 1941 he was a member of a small committee, appointed by President Franklin D. Roosevelt, to evaluate the military importance of research on uranium. This committee's report led to the establishment of the Manhattan Engineering District for nuclear weapons development during WWII. Coolidge lived to be over 100 years old, he had 83 patents to his credit, numerous awards and honorary degrees, and in 1975 was elected to the National Inventor's Hall of Fame. At the time he was the only inventor to receive this honor in his lifetime. Dr. Coolidge was also the first recipient of the AAPM's highest science award - named in his honor. From notes of a day-long interview with Coolidge's son Lawrence in the mid-1990s, previous biographies, publications, books, GE literature, historic photographs, e.g., a wonderful 1874 photo stereoview card with 1 year old baby "Willie Coolidge", and other artifacts in the author's collection, this presentation will review Dr. Coolidge's amazing life, work, accomplishments and awards. "History and Archives Resources at AIP for AAPM and its Members" Gregory A. Good, Ph.D. - Director, AIP Center for History of Physics Melanie J. Mueller, MLIS - Acting Director, AIP Niels Bohr Library & Archives The American Institute of Physics established the Center for History of Physics and the Niels Bohr Library & Archives in the 1960s. Our shared mission is: To preserve and make known the history of the physical sciences. This talk will explore the many ways that AIP's two history programs support the historical and archival activities of AAPM. Topics will include our ongoing oral history program, web outreach through exhibits and teaching guides, and archiving for AAPM and other Member Societies. We will focus in particular on materials in our collections related to the history of medical

  19. Careers and people

    NASA Astrophysics Data System (ADS)

    2008-11-01

    Young scientists fly high Teenagers from Poland, Slovakia and the UK won first prizes at the annual European Union (EU) Contest for Young Scientists. Magdalena Bojarska's study of Hamiltonian cycles in generalized Halin graphs, Martin Tkác's insights on tilting bulk materials in railway cargo and Elisabeth Muller's project on lunar meteorites each garnered awards worth €7000 from the EU's Science in Society programme, which aims to encourage young people to pursue scientific careers.

  20. CAREERS IN INFORMATION SCIENCE,

    DTIC Science & Technology

    Information Science . Sets forth that Information Science is concerned with the properties, behavior, and flow of information...Describes how it is used, both by individuals and in large systems. Discusses the opportunities in Information Science and outlines three relatively...6or participation in these career areas. Concludes that Information Science is a new but rapidly growing field pushing the frontiers of human knowledge and, thus, 3ontributing to human wellbeing and progress.

  1. Foundation doctors career choice and factors influencing career choice.

    PubMed

    Wiener-Ogilvie, Sharon; Begg, Drummond; Dixon, Guy

    2015-11-01

    This study is seeking to establish the factors influencing foundation doctors' decision-making when applying for speciality training. A questionnaire was sent to all foundation doctors in Scotland (n = 1602, response rate 34%) asking them about their career intention in relation to General Practice, whether they received career advice and the extent to which certain factors influenced their career choice. For the majority of trainees, General Practice was not their first choice but just under half were considering it as a career. There were significant differences in career choices between the four Scottish regions and between the medical schools, with a greater proportion of those who studied in Aberdeen and Dundee Medical Schools opting for a career in General Practice. Undergraduate GP placement was reported as the strongest influence in favour of a career in General Practice followed by discussion with family and friends and discussion with speciality trainees. There were differences between medical schools in the way hospital placements, General Practice placements and role models influenced career choices. Career advice on General Practice was reported to be less available and more difficult to find.

  2. Factors Influencing High School Students' Career Aspirations

    ERIC Educational Resources Information Center

    Tang, Mei; Pan, Wei; Newmeyer, Mark D.

    2008-01-01

    This article explores the factors influencing high school students' career aspirations with a study analyzing 141 high school students. The Social Cognitive Career Development Model was utilized to examine the interactive relationships among learning experiences, career self-efficacy, outcome expectations, career interests, and career choices. The…

  3. The Career Development of 10 Year Olds.

    ERIC Educational Resources Information Center

    Seligman, Linda; And Others

    1991-01-01

    Examined career development of 24 preadolescents and assessed how career development was related to their perceptions of their family, self-image, career awareness, interests, and work/family aspirations. Findings suggest that, by age 10, children have thought about their future and can articulate their career and family aspirations. Career goals…

  4. Career Maturity in High School Age Females.

    ERIC Educational Resources Information Center

    Pedro, Joan Daniels

    1982-01-01

    Examined career maturity in high school females by using a set of general career-maturity and gender-specific, career-related measures, and an alternate career-maturity criterion measure, career-planning involvement. Results indicated significant relationships between achievement orientation and occupational information and knowledge of women's…

  5. Expanding the Focus of Career Assessment.

    ERIC Educational Resources Information Center

    Lock, Jared D.; Hogan, Robert

    2000-01-01

    Issues affecting career assessment include change in the focus and definition of career, emphasis on quality of work life, expansion of career paths, increased amount of career information available on the Internet, and questionable quality of online assessment. An expanded model of career assessment now includes technical fit, personal fit,…

  6. The Influence of Teachers' Career Guidance Profiles on Students' Career Competencies

    ERIC Educational Resources Information Center

    Mittendorff, Kariene; Beijaard, Douwe; den Brok, Perry; Koopman, Maaike

    2012-01-01

    In this article, we examine the relationship between different career guidance styles of vocational education teachers and vocational education students' career competencies (i.e. career reflection, career exploration and networking). Questionnaires on students' perceptions of the career guidance of their teachers during career conversations, and…

  7. Career Counselling Development: A Case Study of an Innovative Career Counselling Tool

    ERIC Educational Resources Information Center

    Papakota, Aikaterini

    2016-01-01

    Promoting the use of new technologies in the career counselling process, the Career Services Office of the Aristotle University of Thessaloniki has developed an easy-to-use career counselling guide containing multimedia applications. The purpose of this career guide, called "Career Counseling@Career Office of Aristotle University of…

  8. 5 CFR 317.304 - Conversion of career and career-type appointees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Conversion of career and career-type... Conversion of career and career-type appointees. (a) Coverage. This section covers employees serving under: (1) A career or career-conditional appointment; or (2) A similar type of appointment...

  9. 5 CFR 317.304 - Conversion of career and career-type appointees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Conversion of career and career-type... Conversion of career and career-type appointees. (a) Coverage. This section covers employees serving under: (1) A career or career-conditional appointment; or (2) A similar type of appointment...

  10. 5 CFR 317.304 - Conversion of career and career-type appointees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Conversion of career and career-type... Conversion of career and career-type appointees. (a) Coverage. This section covers employees serving under: (1) A career or career-conditional appointment; or (2) A similar type of appointment...

  11. 5 CFR 317.304 - Conversion of career and career-type appointees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Conversion of career and career-type... Conversion of career and career-type appointees. (a) Coverage. This section covers employees serving under: (1) A career or career-conditional appointment; or (2) A similar type of appointment...

  12. 5 CFR 317.304 - Conversion of career and career-type appointees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Conversion of career and career-type... Conversion of career and career-type appointees. (a) Coverage. This section covers employees serving under: (1) A career or career-conditional appointment; or (2) A similar type of appointment...

  13. Summer 2014 Pathways Report

    NASA Technical Reports Server (NTRS)

    Hand, Zachary

    2014-01-01

    Over the summer I had the exciting opportunity to work for NASA at the Kennedy Space Center as a Mission Assurance Engineering intern. When I was offered a position in mission assurance for the Safety and Mission Assurance directorate's Launch Services Division, I didn't really know what I would be doing, but I knew it would be an excellent opportunity to learn and grow professionally. In this report I will provide some background information on the Launch Services Division, as well as detail my duties and accomplishments during my time as an intern. Additionally, I will relate the significance of my work experience to my current academic work and future career goals. This report contains background information on Mission Assurance Engineering, a description of my duties and accomplishments over the summer of 2014, and relates the significance of my work experience to my school work and future career goals. It is a required document for the Pathways program.

  14. A Missing Link for California's Pathways Movement: CTE Instructional Staff

    ERIC Educational Resources Information Center

    Lundy-Wagner, Valerie

    2016-01-01

    Recently, the State of California committed nearly one billion dollars to the development of career and technical education (CTE) pathways that lead to locally relevant, high-growth, high-demand careers. This investment represents a pivot from relatively disjointed approaches to CTE in high schools and community colleges, and reflects an…

  15. Parental Influence on Young People's Career Development.

    ERIC Educational Resources Information Center

    Otto, Luther B.; Call, Vaughn R. A.

    1985-01-01

    Describes theory and research on parental influence on young people's career development and highlights an important implication of this relationship for career counseling. The authors discuss a seminar that helps parents help their children choose careers. (CT)

  16. National Resource Directory for Marine Careers.

    ERIC Educational Resources Information Center

    Current: The Journal of Marine Education, 1982

    1982-01-01

    Provides a resource directory for marine careers, including name, address, and telephone number of contact persons. Also provides listings of minority professional organizations, organizations supplying information on marine careers, and general reference materials on marine careers. (JN)

  17. Gendering Career Capital: An Investigation of Scientific Careers

    ERIC Educational Resources Information Center

    Duberley, Joanne; Cohen, Laurie

    2010-01-01

    In this article we reflect on the increasingly popular concept of career capital, and apply the concept to data generated with a sample of women scientists. We propose that by examining career capital through a "gendered lens" we can provide insight into structural constraint, often missing in discussions of this concept. Based on the findings…

  18. The Living Career: Complexity, Chaos, Connections and Career.

    ERIC Educational Resources Information Center

    Bloch, Deborah P.

    The purpose of this paper is to present a theory of career development drawn from current work in the physical and biological sciences, specifically work that is associated with chaos and complexity theories. The paper includes specific suggestions for practice based upon the theory and reflections of career professionals on its use. The theory…

  19. Comprehensive Career Guidance. Career Guidance Curriculum. Staff Development K-6.

    ERIC Educational Resources Information Center

    Straub, Vicki W.; Moore, Earl J.

    One of six staff development training manuals for career guidance infusion in the elementary school curriculum (K-6), this manual focuses on the curriculum design of a comprehensive career guidance program. It is divided into the following five major sections: (1) a list of the major goals and activities covered in the manual; (2) an overview…

  20. Executive Career Management: Switching Organizations and the Boundaryless Career

    ERIC Educational Resources Information Center

    Cheramie, Robin A.; Sturman, Michael C.; Walsh, Kate

    2007-01-01

    There has been little research examining executives who change jobs by specifically following these individuals both before and after their employer changes. By incorporating research on the boundaryless career [Arthur, M. B., & Rousseau, D. M. (Eds.). (1996). "The boundaryless career: A new employment principle for a new organizational era." New…

  1. The Role of Career Adaptabilities for Mid-Career Changers

    ERIC Educational Resources Information Center

    Brown, Alan; Bimrose, Jenny; Barnes, Sally-Anne; Hughes, Deirdre

    2012-01-01

    Career adaptability is mediated by personality factors and socio-psychological processes, with learning playing an important role. Using a five-fold career adapt-abilities competency framework (defined here as control, curiosity, commitment, confidence and concern), which was developed from the international quantitative study that is the focus of…

  2. Career Development in Higher Education. Issues in Career Development

    ERIC Educational Resources Information Center

    Samide, Jeff L., Ed.; Eliason, Grafton T., Ed.; Patrick, John

    2011-01-01

    The purpose of Career Development in Higher Education is to provide a broad and in-depth look at the field of career development as it applies to individuals involved in higher education activities, in a variety of educational and vocational training settings. The book will examine some of the field's major themes, approaches and assumptions using…

  3. Career Learning Centers. Career Education Dissemination Project. Implementation Booklet #5.

    ERIC Educational Resources Information Center

    Bonkrude, Marilyn F.; And Others

    Materials contained in this career education implementation guide (one in a series of seven) describe the function and structure of career learning centers (CLC). Major topics discussed include services and strategies, resources, staffing, facilities, evaluation, and budget considerations. Appendixes contain a list of resources and a sample…

  4. Cerulein-induced acute pancreatitis in rats--does bacterial translocation occur via a transperitoneal pathway?

    PubMed

    Arendt, T; Wendt, M; Olszewski, M; Falkenhagen, U; Stoffregen, C; Fölsch, U R

    1997-10-01

    Bacterial infectious complications are the most common cause of morbidity and mortality associated with acute pancreatitis. Most pathogens are common gastrointestinal flora, indicating that the gut is the source of pancreatitis-related infections. However, the route whereby the microorganisms reach distant organs remains speculative. We tested the hypothesis that spread of bacteria occurs via a transperitoneal pathway. Acute interstitial pancreatitis (AIP) was induced in antibiotic (gentamicin, bacithracin, neomycin)-decontaminated rats by intravenous infusion of cerulein. Effects of pancreatic necrosis (PN) were studied in rats that received additional injections into the peritoneal cavity of pancreatic tissue obtained from donor rats. The rats were inoculated with Escherichia coli (O2:KN:H18) resistant to the antibiotics used for decontamination either orally (10(12) microorganisms; experiment I) or intraperitoneally (10(8) microorganisms; experiment II). Moreover, the rat peritoneal cavity wash was inoculated with 10(8) E. coli in vitro (experiment III). In rats with AIP and PN, recovery of the bacteria from liver, spleen, pancreas, lung, and blood following oral inoculation demonstrated that acute pancreatitis promotes bacterial translocation from the gut. The absence of E. coli in these organs following intraperitoneal inoculation showed that the bacteria do not spread from the peritoneal cavity. Rats with PN cleared E. coli from the peritoneal cavity in a shorter period than rats with AIP and controls (5 vs. 7 and 8 days; p < 0.05). The multiplication rate of E. coli in peritoneal cavity wash was lower in rats with PN than in rats with AIP and controls (p < 0.01). We conclude that (1) translocation of E. coli from the gut during cerulein-induced acute pancreatitis occurs via nonperitoneal pathways, (2) the peritoneal cavity acts as a trap for the bacteria rather than a source of bacterial seeding, and (3) PN impairs survival of E. coli in the peritoneal

  5. An Engineering Degree Does Not (Necessarily) an Engineer Make: Career Decision Making among Undergraduate Engineering Majors. Research Brief

    ERIC Educational Resources Information Center

    Lichtenstein, Gary; Loshbaugh, Heidi G.; Claar, Brittany; Chen, Helen L.; Jackson, Kristyn; Sheppard, Sheri

    2009-01-01

    This paper explores the career-related decision making of seniors enrolled in undergraduate engineering programs at two nationally recognized institutions. This strand of the Academic Pathways Study (APS) research revealed that many engineering students were undecided about their career plans, even late into their senior years and that many were…

  6. Promising Practices: School to Career and Postsecondary Education for Foster Care Youth. A Guide for Policymakers and Practitioners.

    ERIC Educational Resources Information Center

    Workforce Strategy Center, Brooklyn, NY.

    Focus of this guide is a project to identify best practices and programs in preparing foster care youth for career opportunities and economic self-sufficiency. Foster care program context is described as an economy characterized by jobs clustering into two categories (high wage positions with a continuing career pathway and low wage entry-level…

  7. Two executives, one career.

    PubMed

    Cunningham, Cynthia R; Murray, Shelley S

    2005-02-01

    For six years, Cynthia Cunningham and Shelley Murray shared an executive job at Fleet Bank. One desk, one chair, one computer, one telephone, and one voice-mail account. To their clients and colleagues, they were effectively one person, though one person with the strengths and ideas of two, seamlessly handing projects back and forth. Although their department was dissolved after the bank merged with Bank of America, the two continue to consider themselves a package-they have one resume, and they are seeking their next opportunity together. Their choice to share a job was not only a quality-of-life decision but one intended to keep their careers on course: "Taking two separate part-time jobs would have thrown us completely off track" they write in this first-person account."We're both ambitious people, and neither of us wanted just a job. We wanted careers" In this article, the two highly motivated women reveal their determination to manage the demands of both family and career. Flextime,telecommuting, and compressed workweeks are just some of the options open to executives seeking greater work/ life balance, and the job share, as described by Cunningham and Murray, could well be the next solution for those wishing to avoid major trade-offs between their personal and professional lives. Cunningham and Murray describe in vivid detail how they structured their unusual arrangement, how they sold themselves to management, and the hurdles they faced along the way. Theirs is a win-win story, for the company and for them.

  8. Career perspective: Paolo Cerretelli

    PubMed Central

    2013-01-01

    This article is an autobiographical account of my career as a human physiologist. I have spent 55 years traversing mountains, continents, seas, and skies, carrying out research in the laboratories of several international institutions as well as in the field. My scientific roots, approach to the mountains and altitude populations, both in Europe and in Asia, together with an account of my experimental studies at altitude, including extreme conditions, shall be presented together with pertinent occasional reflections of a personal nature. PMID:24438551

  9. Careers and people

    NASA Astrophysics Data System (ADS)

    2009-03-01

    'Lifetime award' for stellar research George Preston of the Carnegie Observatories in Pasadena, California, has been awarded the 2009 Henry Norris Russell Lecturership, the highest distinction given by the American Astronomical Society (AAS). Preston has spent his career studying how old, metalpoor stars in the Milky Way evolve, and his findings have led to a new understanding of stellar magnetic fields and a group of pulsating stars known as R R Lyrae variables. He will receive the "lifetime achievement" prize when he delivers a lecture at the annual meeting of the AAS in January 2010. Other awards are listed on the society's website.

  10. AAS Career Services

    NASA Astrophysics Data System (ADS)

    Marvel, Kevin B.

    2012-08-01

    The American Astronomical Society provides substantial programs in the area of Career Services.Motivated by the Society's mission to enhance and share humanity's understanding of the Universe, the AAS provides a central resource for advertising positions, interviewing opportunities at its annual winter meeting and information, workshops and networks to enable astronomers to find employment.The programs of the Society in this area are overseen by an active committee on employment and the AAS Council itself.Additional resources that help characterize the field, its growth and facts about employment such as salaries and type of jobs available are regularly summarized and reported on by the American Institute of Physics.

  11. Career Directions for Drafting CAD Technicians.

    ERIC Educational Resources Information Center

    Moore, Pam

    2002-01-01

    Provides information careers for drafting/computer-assisted drafting technicians, including salaries, responsibilities, employment outlook, working conditions, skills needed, and career advancement opportunities. Lists professional drafting organizations. (JOW)

  12. Community Colleges Need Comprehensive Career Assistance Centers.

    ERIC Educational Resources Information Center

    Davies, Timothy Gray; Feller, Rich

    1999-01-01

    Community colleges currently offer fragmented services that marginalize disadvantaged students. A comprehensive career-assistance center could provide integrated academic, career, and personal services. (SK)

  13. Career Services and Enrollment Management.

    ERIC Educational Resources Information Center

    Case, Jim

    1989-01-01

    Describes experiences in University of Rochester's marketing-oriented career services division which demonstrates that marketing alliance of admissions, academics, alumni, and career planning and placement can work. Includes missions and goals statement of that university's enrollment, placement, and alumni affairs division. (NB)

  14. [Secondary Career Education Activities: Science.

    ERIC Educational Resources Information Center

    Radford City Schools, VA.

    The guide is one of a series developed in a pilot project to integrate career education concepts with subject matter in secondary grades. The units are designed to reveal career orientation aspects of traditional topics within five major subject areas: English, social studies, mathematics, science, and health and physical education. The lesson…

  15. Career and Occupational Development Items.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. National Assessment of Educational Progress.

    The career and occupational development items contained in this document are part of a kit consisting of four documents which bring together different types of items that measure a number of career and occupational development (COD) objectives developed by the National Assessment of Educational Progress (NAEP). (NAEP--which completed a national…

  16. Foreign Languages and Your Career.

    ERIC Educational Resources Information Center

    Bourgoin, Edward

    Divided into two major parts, this book is intended to indicate careers in which people need foreign languages in their work and to provide suggestions and sources of further information for those who already have foreign language skills and those who are planning to acquire them. Part 1 discusses careers in which a foreign language is needed as a…

  17. Career Education: Implications for Minorities.

    ERIC Educational Resources Information Center

    Sheppard, N. Alan; Witherspoon, Everette L.

    In general, minorities, especially blacks, approach career education warily, fearing it might turn out to be a new name for an old game. Statistics indicate the minority dilemma; for example, unemployment among minorities 16 and older is nearly twice the white unemployment rate. A number of critical questions about career education as related to…

  18. Minorities Access to Research Careers.

    ERIC Educational Resources Information Center

    American Association of State Colleges and Universities, Washington, DC.

    The Minorities Access to Research Careers (MARC) program at Hunter College, New York is designed to provide an in-depth 2-year research training experience for minority students in order to prepare them for graduate school and eventual research careers in alcohol, drug abuse, and mental health fields. The target groups include Blacks, Hispanics,…

  19. Career Education Guide, K-14.

    ERIC Educational Resources Information Center

    Lakeshore Technical Inst., Sheboygan, WI.

    This expanded career education teaching guide for Kindergarten through Grade 14 presents a career development model, rationales for various grade levels, and general goals and concepts for an integrated curriculum. Developed at a federally funded summer workshop by 11 counselors, 76 teachers, resource consultants, and leaders in business and…

  20. Career Satisfaction Following Technical Education

    ERIC Educational Resources Information Center

    McDonald, Betty Manager

    2011-01-01

    The effect of career and technical education in the Caribbean is an area of intervention research that needs more attention. This present research is the first of its kind within the region. The study benefits from a large sample size (N = 500) conducted among a non-traditional population in the field of career development. This paper reports on…

  1. Adult Career Assessment: Personality Measures.

    ERIC Educational Resources Information Center

    Vansickle, Timothy R.; Russell, Mary T.

    1996-01-01

    Provides an overview of five assessment instruments and discusses their contribution to adult career development: (1) California Personality Inventory; (2) Myers-Briggs Type Indicator; (3) Personality Research Form; (4) Occupational Stress Inventory; and (5) Personal Career Development Profile. Includes information about publishers, intended…

  2. Developmental Career Education: Primary Years.

    ERIC Educational Resources Information Center

    New Hampshire State Dept. of Education, Concord.

    The series of activities are designed to provide experiences for primary grade students to: formulate goals, develop positive self-concepts, develop positive attitudes, evaluate career decisions, and adjust toward their career aspirations. The 36 activities focus on: self-awareness, values, personal growth and interests, work, occupational…

  3. Retirement Patterns from Career Employment

    ERIC Educational Resources Information Center

    Cahill, Kevin E.; Giandrea, Michael D.; Quinn, Joseph F.

    2006-01-01

    Purpose: This article investigates how older Americans leave their career jobs and estimates the extent of intermediate labor force activity (bridge jobs) between full-time work on a career job and complete labor-force withdrawal. Design and Methods: Using data from the Health and Retirement Study, we explored the work histories and retirement…

  4. Changing Careers: Steps to Success.

    ERIC Educational Resources Information Center

    Sikula, Lola

    This book is intended to assist adults who are contemplating changing careers or actually doing so. The information, exercises, questionnaires, guides, and bibliographies included in it are designed to give adults the coping skills to adapt to and work through the personal, financial, and other changes that accompany the career change process. The…

  5. Career Maturity of Welfare Recipients.

    ERIC Educational Resources Information Center

    Beckman, Carol M.

    To investigate the career maturity of welfare recipients, this thesis examines six independent variables: (1) race; (2) sex; (3) age; (4) level of formal education; (5) general intelligence; and (6) locus of control. Scales taken from the Career Maturity Inventory served as the dependent variables. The sample consisted of 83 welfare recipients who…

  6. Limitless Horizons. Careers in Aerospace

    NASA Technical Reports Server (NTRS)

    Lewis, M. H.

    1980-01-01

    A manual is presented for use by counselors in career guidance programs. Pertinent information is provided on choices open in aerospace sciences, engineering, and technology. Accredited institutions awarding degrees in pertinent areas are listed as well as additional sources of aerospace career information. NASA's role and fields of interest are emphasized.

  7. Organizational Downsizing and Career Development.

    ERIC Educational Resources Information Center

    Bozionelos, Nikos

    2001-01-01

    A study of 123 "survivors" of corporate downsizing and 13 senior managers indicated that the organization lacked a coherent career development plan and the performance management/appraisal process was inadequate. Managers perceived lateral transfers as effective; some employees felt they undermined career progression. Employees thought…

  8. Business Alliances Improve Career Awareness

    ERIC Educational Resources Information Center

    Kirkpatrick, Megan E.; Droessler, Christopher L.

    2007-01-01

    Preparing every student to make knowledgeable career choices through academic rigor and work-based learning experiences requires a systematic, comprehensive and community-wide effort. Schools cannot truly prepare their students for productive and rewarding careers in an academic vacuum. Engaging business and community leaders, who may someday hire…

  9. Your 50-Year Career Plan

    ERIC Educational Resources Information Center

    Perlmutter, David D.

    2007-01-01

    In this article, the author discusses the meaning and importance of the long-term view in the academic profession. Taking the half-century view of a career allows everyone to conceptualize his/her work as both a solitary venture and a group effort. As your career develops and you build alliances and partnerships with colleagues--and then with…

  10. Success and Women's Career Adjustment.

    ERIC Educational Resources Information Center

    Russell, Joyce E. A.; Burgess, Jennifer R. D.

    1998-01-01

    Women still face barriers to career success and satisfaction: stereotypes, assumptions, organizational culture, human resource practices, and lack of opportunities. Despite individual and organizational strategies, many women leave to become entrepreneurs. There is a need to investigate how women define career success. (SK)

  11. Career Indications Among Junior Officers.

    ERIC Educational Resources Information Center

    Shenk, Faye

    A study of officer input from the principal Air Force commissioning programs was undertaken to determine the predictability of an Air Force officer's career decision and to evaluate relationships between career intent and various demographic, environmental, and attitudinal factors. This report describes the study and provides a preliminary…

  12. PATERNAL INFLUENCE ON CAREER CHOICE.

    ERIC Educational Resources Information Center

    WERTS, CHARLES E.

    FATHER'S OCCUPATION WAS COMPARED WITH SON'S CAREER CHOICE FOR A SAMPLE OF 76,015 MALE, COLLEGE FRESHMEN. RESULTS INDICATED THAT CERTAIN TYPES OF FATHERS' OCCUPATIONS WERE ASSOCIATED WITH SIMILAR TYPES OF CAREER CHOICES BY SONS. BOYS WHOSE FATHERS WERE IN SCIENTIFIC OCCUPATIONS (ENGINEERS, MILITARY OFFICERS, ARCHITECTS, BIOLOGISTS, CHEMISTS, AND…

  13. Planning Guide for Career Academies

    ERIC Educational Resources Information Center

    Dayton, Charles

    2010-01-01

    A career academy is a small learning community within a high school, which selects a subset of students and teachers for a two-, three-, or four-year period. Students enter through a voluntary process; they must apply and be accepted, with parental knowledge and support. A career academy involves teachers from different subjects working together…

  14. Women and Career Development. Symposium.

    ERIC Educational Resources Information Center

    2002

    Three papers comprise this symposium on women and career development. "Enhancing the Career Success of Women Faculty: Mentoring as a Human Resource Development (HRD) Initiative in Higher Education" (Sharon K. Gibson) explores mentoring of women faculty, focusing on the key dimensions of roles and functions, outcomes, gender, and formal…

  15. Portfolio Careerism: Are You Ready?

    ERIC Educational Resources Information Center

    Stevens, Paul

    A career is a discontinuous a series of work roles using different personal attributes, skills, knowledge, interests, and wants. Individuals must examine their portfolio, select and rearrange it, and then sell themselves to the manager where they work or prospective clients/employers in the marketplace. Individuals should view career capabilities…

  16. Education Careers: Teacher Resource Guide.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Curriculum Center for Family and Consumer Sciences.

    This teacher resource guide is an instructional resource for these three separate courses: exploring education careers, elementary school teacher assistant, and elementary school teaching internship. (Exploring education careers is designed as a field-based internship that provides students a background knowledge of child and adolescent…

  17. Career Education Community Resource Guide.

    ERIC Educational Resources Information Center

    D'Lugin, Victor; And Others

    This guide, developed by the State Project to Implement Career Education (SPICE) in New York, is intended to serve as a model to assist teachers, guidance counselors, administrators, and project staff in using business and community resources in career education programs. The first section of the guide contains information on ways of updating and…

  18. Portraying Careers Awareness in Aviation.

    ERIC Educational Resources Information Center

    Buckingham, Roy A.; Amato, Vincent

    1980-01-01

    Discusses the purpose of the half-day program at Indiana State University which provides some notion of careers available in the aviation industry focusing on the professional pilot career. It utilizes the simulators and aviation teaching materials within the Aerospace Department's inventory to help orient college-bound high school students to…

  19. Career Development and Public Policy.

    ERIC Educational Resources Information Center

    Borges, Nicole J.; Savickas, Mark L.

    Career development specialists need to find ways to adapt their knowledge and skills to become agents of social action. Public policy is one area where career development specialists can involve themselves to help bring about social change. This paper attempts to raise the consciousness of Society of Vocational Psychology (SVP) members and to…

  20. Colorado Career Development Video Reviews.

    ERIC Educational Resources Information Center

    Feller, Rich; Jacobsen, Brent

    The average number of points assigned by 15-25 reviewers to each of 13 guidance and career development videotapes is recorded in a video quality assessment matrix. Reviewers were participants in Colorado State University's 1989-90 Colorado Career Guidance Video Review Project training sessions and videotapes were rated on: (1) instructional…