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Sample records for aip conf proc

  1. Report on AIP--1971

    ERIC Educational Resources Information Center

    Physics Today, 1972

    1972-01-01

    The 1971 annual report by the American Institute of Physics (AIP) is highlighted. The report deals with AIP activities during 1971, including changes in publishing methods, new products from the physics-information division, and internal reorganization for better service. (PR)

  2. Programmability in AIPS++

    NASA Technical Reports Server (NTRS)

    Hjellming, R. M.

    1992-01-01

    AIPS++ is an Astronomical Information Processing System being designed and implemented by an international consortium of NRAO and six other radio astronomy institutions in Australia, India, the Netherlands, the United Kingdom, Canada, and the USA. AIPS++ is intended to replace the functionality of AIPS, to be more easily programmable, and will be implemented in C++ using object-oriented techniques. Programmability in AIPS++ is planned at three levels. The first level will be that of a command-line interpreter with characteristics similar to IDL and PV-Wave, but with an intensive set of operations appropriate to telescope data handling, image formation, and image processing. The third level will be in C++ with extensive use of class libraries for both basic operations and advanced applications. The third level will allow input and output of data between external FORTRAN programs and AIPS++ telescope and image databases. In addition to summarizing the above programmability characteristics, this talk will given an overview of the classes currently being designed for telescope data calibration and editing, image formation, and the 'toolkit' of mathematical 'objects' that will perform most of the processing in AIPS++.

  3. AIP Career Pathways

    NASA Astrophysics Data System (ADS)

    Palchak, Amanda

    2012-02-01

    American Institute of Physics (AIP) Career Pathways is a new project funded by the National Science Foundation. One of the goals of AIP Career Pathways is to prepare students to compete for Science, Technology, Engineering, and Mathematics (STEM) careers with a bachelor's degree in physics. In order to do so, I reviewed and compiled useful resources on finding a STEM career with a bachelor's degree in physics. These resources not only supply the job seeker with job postings in STEM careers but also provide them with information on resumes, interviewing skills, and networking. Recently at the 2011 Industrial Physics Forum, I interviewed companies in the private sector to obtain a unique perspective on what types of skills potential employers expect an applicant to posses with a bachelor's degree in physics. Ultimately, these components will be used as supplements at student career workshops held at annual Society of Physics Students Zone Meetings.

  4. Proc. Agent 2004 Conf. on Social Dynamics : Interaction, Reflexivity and Emergence

    SciTech Connect

    C. M. Macal, D. Sallach, M. J. North, eds.

    2004-01-01

    I'd like to welcome you to the Agent 2004 conference. As most of you are aware, this conference is the fifth in a series of meetings that began in 1999. A conference followed the next year in 2000. The 2001 conference was skipped because of some conflicts with other conferences, and the conferences have proceeded annually since then. We have the proceedings of the previous conferences available here on CDs. One CD has the proceedings from 1999, 2000, and 2002; the other contains last year's proceedings. The purpose of these conferences is to advance the state of the computational social sciences and to integrate the social sciences with the decision sciences and something that is traditionally known as the management sciences. Those of you in the operations/research area are familiar with the traditional school of modeling simulation that emerged from that scientific area. This conference will bring together a different group of people to talk about the topic of agent-based theories and simulations. This fifth agent conference is one of a group of conferences held annually around the country. Most of you are probably aware of the CASOS Conference held at Carnegie Mellon University, usually in July. UCLA holds the Arrowhead Conference, generally around May. The University of Michigan is now holding a conference as well. Of course everyone is aware of SwarmFest, which has been held annually for about a decade. The Swarm seems to 'swarm' in different locations each year. As you're well aware, this conference is organized into a three-day program. This is the first time we've used three days for the full conference setting. Last year, we held simultaneous sessions, and that didn't work well for most of those who attended. We had complaints from people who missed sessions and papers because of scheduling, so we decided to extend this year's conference by one day. As a result, we now have a program designed to present the papers in a serial sequence rather than in a parallel manner. Today, we'll focus on toolkits. Tomorrow we'll look at computational social theory, and Saturday is application day. We'll talk about how we're taking some of the theories and toolkits to look at real-world problems in order to understand how our very complex world works and maybe even to predict how it might work in the future. In addition to the content of the papers themselves, one of the more important things about this conference is the discussion that is inspired by these papers. I invite you to ask penetrating questions, offer insightful comments, share your experiences with toolkits or your ideas on theories, and help to create an atmosphere that will help this field move along and grow. It's a fairly new science--it is just emerging--but it seems to have been gaining momentum in the last couple of years. This is a conference to get your energy going and perhaps foster your creativity. With that, I welcome you to Agent 2004; have a great time at the conference.

  5. AIP Member Societies Entering the 1980's. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    Information is presented on the composition of the 1979 membership of the American Institute of Physics (AIP). Questionnaires were administered to members of the nine independent societies of the AIP to determine demographic and employment information. Background characteristics of the membership include the following: more than half identify…

  6. AIP's Career Pathways Project

    NASA Astrophysics Data System (ADS)

    Avila, Jose

    2014-03-01

    The American Institute of Physics (AIP) Career Pathways Project, funded by the National Science Foundation, aims to increase the number of undergraduates going into STEM careers. The main purposes of this project are to show students the professional opportunities for a STEM career, understand what departments can do to better prepare physics bachelor's degree recipients to enter the workforce, understand what students can do to better prepare themselves, and develop resources based on these findings. I was chosen by the Society of Physics Students (SPS) to be the 2013 summer intern of the AIP's Career Pathways Project. In this talk I will discuss several resources I worked on with the Statistical Research Center of the American Institute of Physics and SPS. These resources include how to write a resume and cover letter, how to perform an informational interview, common job titles for physics bachelors, how to find career information in physics and STEM, how to search and use job postings, and how to network.

  7. AIP and its interacting partners.

    PubMed

    Trivellin, Giampaolo; Korbonits, Márta

    2011-08-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to young-onset pituitary tumours, most often to GH- or prolactin-secreting adenomas, and most of these patients belong to familial isolated pituitary adenoma families. The molecular pathway initiated by the loss-of-function AIP mutations leading to pituitary tumour formation is unknown. AIP, a co-chaperone of heat-shock protein 90 and various nuclear receptors, belongs to the family of tetratricopeptide repeat (TPR)-containing proteins. It has three antiparallel α-helix motifs (TPR domains) that mediate the interaction of AIP with most of its partners. In this review, we summarise the known interactions of AIP described so far. The identification of AIP partners and the understanding of how AIP interacts with these proteins might help to explain the specific phenotype of the families with heterozygous AIP mutations, to gain deeper insight into the pathological process of pituitary tumour formation and to identify novel drug targets.

  8. Advanced Integrated Power Systems (AIPS)

    DTIC Science & Technology

    2012-10-08

    save fuel used for generating electricity in an austere location for a military deployment application. The contractor performed testing of four...45 Appendix B: AIPS Electrical Schematic Diagrams ...................................................................53 LIST OF SYMBOLS...16 Figure 20. Konarka Panel Electrical Grouping

  9. Advanced Information Processing System (AIPS)

    NASA Technical Reports Server (NTRS)

    Pitts, Felix L.

    1993-01-01

    Advanced Information Processing System (AIPS) is a computer systems philosophy, a set of validated hardware building blocks, and a set of validated services as embodied in system software. The goal of AIPS is to provide the knowledgebase which will allow achievement of validated fault-tolerant distributed computer system architectures, suitable for a broad range of applications, having failure probability requirements of 10E-9 at 10 hours. A background and description is given followed by program accomplishments, the current focus, applications, technology transfer, FY92 accomplishments, and funding.

  10. Employment Survey 1976. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    This document presents the summary results of the 1976 employment survey of physics and astronomy graduates of the class of 1975-76 as conducted by the American Institute of Physics (AIP). Data presented include employment status 6-18 months after graduation; background characteristics of doctoral, master's and bachelor's level physicists; time…

  11. Planetary Radars Operating Centre PROC

    NASA Astrophysics Data System (ADS)

    Catallo, C.; Flamini, E.; Seu, R.; Alberti, G.

    2007-12-01

    Planetary exploration by means of radar systems, mainly using Ground Penetrating Radars (GPR) plays an important role in Italy. Numerous scientific international space programs are currently carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three important experiments under Italian leadership ( designed and manufactured by the Italian industry), provided by ASI either as contribution to ESA programs either within a NASA/ASI joint venture framework, are now operating: MARSIS on-board Mars Express, SHARAD on-board Mars Reconnaissance Orbiter and CASSINI Radar on-board Cassini spacecraft. In order to support all the scientific communities, institutional customers and experiment teams operation three Italian dedicated operational centers have been realized, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD ( Processing Altimetry Data). Each center is dedicated to a single instrument management and control, data processing and distribution. Although they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). PROC is conceived in order to include the three operational centers, namely SHOC, MOC and CASSINI PAD, either from logistics point of view and from HW/SW capabilities point of view. The Planetary Radar Processing Center shall be conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs. Therefore, scalability, easy use and management shall be the design drivers. The paper describes how PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. Furthermore, in the frame of

  12. ConfChem Conference on Flipped Classroom: Spring 2014 ConfChem Virtual Poster Session

    ERIC Educational Resources Information Center

    Belford, Robert E.; Stoltzfus, Matthew; Houseknecht, Justin B.

    2015-01-01

    This communication describes the virtual poster session of the Flipped Classroom online ConfChem conference that was hosted by the ACS CHED Committee on Computers in Chemical Education (CCCE) from May 9 to June 12, 2014. During the conference's online discussions, it became evident that multiple participants who were not presenting papers had been…

  13. AIP Member Societies Entering the 1980's.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn

    1981-01-01

    Summarizes results of a survey conducted by the Manpower Statistics Division of the American Institute of Physics (AIP). Questions were asked of nine member societies of the AIP concerning demographic and employment data such as professional self-identification, type of employer by highest degree, primary work activity, and annual salary. (CS)

  14. Differences in ODS formatting for HTML with Proc Print and Proc Report

    Technology Transfer Automated Retrieval System (TEKTRAN)

    While proc print is a terrific tool for data checking and data summary, proc report is similar to, but more powerful because it can do some basic calculations or statistics and data can be broken more effectively into manageable fields. The ODS procedure can produce HTML files from either procedure...

  15. AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic responses

    PubMed Central

    Zhou, Huanjiao Jenny; Chen, Xiaodong; Liu, Renjing; Zhang, Haifeng; Wang, Yingdi; Jin, Yu; Liang, Xiaoling; Lu, Lin; Xu, Zhe; Min, Wang

    2014-01-01

    Objective To investigate the novel function of AIP1 in VEGFR-3 signaling, and VEGFR-3-dependent angiogenesis and lymphangiogenesis. Approach/Results AIP1, a signaling scaffold protein, is highly expressed in the vascular endothelium. We have previously reported that AIP1 functions as an endogenous inhibitor in pathological angiogenesis by blocking VEGFR-2 activity. Surprisingly, here we observe that mice with a global deletion of AIP1 (AIP1-KO) exhibit reduced retinal angiogenesis with less sprouting and fewer branches. Vascular endothelial cell (but not neuronal)-specific deletion of AIP1 causes similar defects in retinal angiogenesis. The reduced retinal angiogenesis correlates with reduced expression in VEGFR-3 despite increased VEGFR-2 levels in AIP1-KO retinas. Consistent with the reduced expression of VEGFR-3, AIP1-KO mice show delayed developmental lymphangiogenesis in neonatal skin and mesentery, and mount weaker VEGF-C-induced cornea lymphangiogenesis. In vitro, human lymphatic EC with AIP1 siRNA knockdown, retinal EC and lymphatic EC isolated from AIP1-KO all show attenuated VEGF-C-induced VEGFR-3 signaling. Mechanistically, we demonstrate that AIP1 via vegfr-3-specific miR-1236 increases VEGFR-3 protein expression, and by directly binding to VEGFR-3 enhances VEGFR-3 endocytosis and stability. Conclusion Our in vivo and in vitro results provide the first insight into the mechanism by which AIP1 mediates VEGFR-3-dependent angiogenic and lymphangiogenic signaling. PMID:24407031

  16. Bachelor's Degree Recipients Report 1995. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Dodge, Elizabeth

    This document reports on a 1995 survey of students graduating with a bachelor's degree in physics or astronomy as part of an ongoing series of surveys that have been conducted by the American Institute of Physics (AIP) since the 1960s. The data obtained on the 1995 class build upon established trends in students' immediate postbaccalaureate plans…

  17. An enhanced Planetary Radar Operating Centre (PROC)

    NASA Astrophysics Data System (ADS)

    Catallo, C.

    2010-12-01

    Planetary exploration by means of radar systems, mainly using GPRs is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are successfully operating: MARSIS on-board MEX, SHARAD on-board MRO and CASSINI Radar on-board Cassini spacecraft: the missions have been further extended . Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the missions beginning to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how the new PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation aiding scientists to increase their knowledge in the field of surface

  18. PROC: a new Planetary Radars Operating Centre

    NASA Astrophysics Data System (ADS)

    Catallo, C.; Alberti, G.; Flamini, E.; Olivieri, A.; Orosei, R.

    2009-12-01

    Planetary exploration by means of radar systems, mainly using Ground Penetrating Radars (GPR) is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Actually three important experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are operating in the frame of an extended missions : MARSIS on-board Mars Express, SHARAD on-board Mars Reconnaissance Orbiter and CASSINI Radar on-board Cassini spacecraft. Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the starting of the missions in order In order to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and

  19. Validation environment for AIPS/ALS: Implementation and results

    NASA Technical Reports Server (NTRS)

    Segall, Zary; Siewiorek, Daniel; Caplan, Eddie; Chung, Alan; Czeck, Edward; Vrsalovic, Dalibor

    1990-01-01

    The work is presented which was performed in porting the Fault Injection-based Automated Testing (FIAT) and Programming and Instrumentation Environments (PIE) validation tools, to the Advanced Information Processing System (AIPS) in the context of the Ada Language System (ALS) application, as well as an initial fault free validation of the available AIPS system. The PIE components implemented on AIPS provide the monitoring mechanisms required for validation. These mechanisms represent a substantial portion of the FIAT system. Moreover, these are required for the implementation of the FIAT environment on AIPS. Using these components, an initial fault free validation of the AIPS system was performed. The implementation is described of the FIAT/PIE system, configured for fault free validation of the AIPS fault tolerant computer system. The PIE components were modified to support the Ada language. A special purpose AIPS/Ada runtime monitoring and data collection was implemented. A number of initial Ada programs running on the PIE/AIPS system were implemented. The instrumentation of the Ada programs was accomplished automatically inside the PIE programming environment. PIE's on-line graphical views show vividly and accurately the performance characteristics of Ada programs, AIPS kernel and the application's interaction with the AIPS kernel. The data collection mechanisms were written in a high level language, Ada, and provide a high degree of flexibility for implementation under various system conditions.

  20. Immunogenetics of IgG4-Related AIP.

    PubMed

    Ota, Masao; Umemura, Takeji; Kawa, Shigeyuki

    2017-01-01

    Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis characterized by high serum IgG4 concentration and a variety of complicating extra-pancreatic lesions. AIP has the features of a complex disease that is caused by multifactorial genes. However, the genetic factors underlying AIP have not been elucidated conclusively. Association studies by the candidate-gene approach and genome-wide association studies (GWAS) have revealed several susceptibility genes for AIP, including HLA DRB1*04:05-DQB1*04:01, FCRL3, CTLA4, and KCNA3, albeit in small-scale analyses. Thus, GWAS of large sample sizes and multinational collaborative meta-analyses are needed to identify the precise genetic variants that are associated with AIP onset. Systems genetics approaches that integrate DNA sequencing, expression quantitative trait locus (eQTL) mapping, proteomics, and metabolomics will also be useful in clarifying the pathogenesis of AIP.

  1. AIP 50th anniversary: Physics vade mecum

    NASA Astrophysics Data System (ADS)

    Anderson, H. L.

    This compendium is intended to be of use to the wide spectrum of physicists associated with the AIP through its member societies. Twenty-two subjects broadly representative of physics as a whole are discussed. Each subeditor was charged to compile within 10 pages the most useful information, formulas, numerical data, definitions, and references most physicists would like to have at hand. The General Section is a compilation of the fundamental constants, the SI units and prefixes, conversion factors, magnitudes, basic mathematical and physics formulas, formulas useful in practical physics applications, and a list of physics data centers. The particular fields considered are: acoustics, astronomy and astrophysics, atomic collision properties, atomic spectroscopy, biological physics, cryogenics, crystallography, elementary particles, energy demand, energy supply, fluid dynamics, high polymer physics, medical physics, molecular spectroscopy and structure, nuclear physics, optics, plasma physics, rheology, solid state physics, surface physics, and thermophysics.

  2. Resources for History of Geophysics at AIP

    NASA Astrophysics Data System (ADS)

    Good, G. A.

    2012-12-01

    The history programs of the American Institute of Physics -- the Center for History of Physics and the Niels Bohr Library & Archives -- maintain a wide variety of research resources for the history of physics generally, and for the history of geophysics in particular. AIP has over 20,000 photographs online, nearly 1000 oral history interview transcripts, and much more. The International Catalog of Sources provides an online union catalog of manuscript collections held worldwide. An important collection of IUGG records is available onsite, as also is the recently accessioned collection of AGU papers. As the 2019 centenary of AGU approaches, these resources will be of interest to both AGU members and historians of science.;

  3. Molecular genetics of the aip gene in familial pituitary tumorigenesis.

    PubMed

    Tahir, Asil; Chahal, Harvinder S; Korbonits, Márta

    2010-01-01

    Pituitary adenomas usually occur as sporadic tumors, but familial cases are now increasingly identified. As opposed to multiple endocrine neoplasia type 1 and Carney complex, in familial isolated pituitary adenoma (FIPA) syndrome no other disease is associated with the familial occurrence of pituitary adenomas. It is an autosomal dominant disease with incomplete variable penetrance. Approximately 20% of patients with FIPA harbour germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene located on 11q13. Patients with AIP mutations have an overwhelming predominance of somatotroph and lactotroph adenomas, which often present in childhood or young adulthood. AIP, originally identified as a molecular co-chaperone of several nuclear receptors, is thought to act as a tumor suppressor gene; overexpression of wild-type, but not mutant AIP, reduces cell proliferation while knockdown of AIP stimulates it. AIP is shown to bind various proteins, including the aryl hydrocarbon receptor, Hsp90, phosphodiesterases, survivin, RET and the glucocorticoid receptor, but currently it is not clear which interaction has the leading role in pituitary tumorigenesis. This chapter summarizes the available clinical and molecular data regarding the role of AIP in the pituitary gland.

  4. AIP history center seeks old books and photographs

    NASA Astrophysics Data System (ADS)

    AGU members can give essential help to an effort to gather materials that are important for education and public understanding of geophysics. Now that AGU is a Member Society of the American Institute of Physics (AIP), the AIP Center for History of Physics is striving to enlarge its collections of materials on the history of geophysics. They are appealing to AGU members to help AIP locate and acquire materials, such as classic textbooks and old snapshots, that will be invaluable to future historians and educators.

  5. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.

    PubMed

    Zhang, Jiqin; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang

    2015-05-01

    AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC). While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein). Human genome-wide association study (GWAS) has identified DAB2IP gene variants conferring susceptibility to cardiovascular diseases. Consistently, a global or vascular EC-specific deletion of DAB2IP in mice strongly enhances inflammatory responses and exacerbates atherosclerosis and graft arteriosclerosis progression in mouse models. Mechanisms for AIP1 function and regulation associated with human cardiovascular diseases need further investigations.

  6. Cortical connections of the macaque anterior intraparietal (AIP) area.

    PubMed

    Borra, Elena; Belmalih, Abdelouahed; Calzavara, Roberta; Gerbella, Marzio; Murata, Akira; Rozzi, Stefano; Luppino, Giuseppe

    2008-05-01

    We traced the cortical connections of the anterior intraparietal (AIP) area, which is known to play a crucial role in visuomotor transformations for grasping. AIP displayed major connections with 1) areas of the inferior parietal lobule convexity, the rostral part of the lateral intraparietal area and the SII region; 2) ventral visual stream areas of the lower bank of the superior temporal sulcus and the middle temporal gyrus; and 3) the premotor area F5 and prefrontal areas 46 and 12. Additional connections were observed with the caudal intraparietal area and the ventral part of the frontal eye field. This study suggests that visuomotor transformations for object-oriented actions, processed in AIP, rely not only on dorsal visual stream information related to the object's physical properties but also on ventral visual stream information related to object identity. The identification of direct anatomical connections with the inferotemporal cortex suggests that AIP also has a unique role in linking the parietofrontal network of areas involved in sensorimotor transformations for grasping with areas involved in object recognition. Thus, AIP could represent a crucial node in a cortical circuit in which hand-related sensory and motor signals gain access to representations of object identity for tactile object recognition.

  7. ConfMatch: automating electron-density map interpretation by matching conformations.

    PubMed

    Wang, C E

    2000-12-01

    Building a protein model from the initial three-dimensional electron-density distribution (density map) is an important task in X-ray crystallography. This problem is computationally challenging because proteins are extremely flexible. The algorithm ConfMatch is a global real-space fitting procedure in torsion-angle space. It solves this 'map-interpretation' problem by matching a detailed conformation of the molecule to the density map (conformational matching). This 'best-match' structure is defined as one which maximizes the sum of the density at atom positions. ConfMatch is a practical systematic algorithm based on a branch-and-bound search. The most important idea of ConfMatch is an efficient method for computing accurate bounds. ConfMatch relaxes the conformational matching problem, a problem which can only be solved in exponential time, into one which can be solved in polynomial time. The solution to the relaxed problem is a guaranteed upper bound for the conformational matching problem. In most empirical cases, these bounds are accurate enough to prune the search space dramatically, enabling ConfMatch to solve structures with more than 100 free dihedral angles. Experiments have shown that ConfMatch may be able to automate the interpretation of density maps of small proteins.

  8. On AIPS++, a new astronomical information processing system

    NASA Technical Reports Server (NTRS)

    Croes, G. A.

    1992-01-01

    The AIPS system that has served the needs of the radio astronomical community remarkably well during the last 15 years is showing signs of age and is being replaced by a more modern system, AIPS++. As the name implies, AIPS++ will be developed in a object oriented fashion and will use C++ as its main programming language. The work is being done by a consortium of seven organizations, with coordinated activities worldwide. After a review of the history of the project to this date from management, astronomical and technical viewpoints, and the current state of the project, the paper concentrates on the tradeoffs implied by the choice of implementation style and the lessons we have learned, good and bad.

  9. 76 FR 44978 - Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ...-0786] Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds AGENCY... Program (AIP) must notify, in writing, the designated representative in the appropriate FAA Regional or... grants to the following year. In such cases, the FAA converts the current-year funds to AIP...

  10. Some Comments on Marketing AIP Information Products and Services.

    ERIC Educational Resources Information Center

    King, Donald W.; Brown, A. M.

    This study was addressed to marketing considerations for the American Institute of Physics (AIP) information products and services. The general system and its operation in a marketing environment, including promotion, channels of distribution and pricing are covered. Particular emphasis is placed on the cost/demand/price relationship for four…

  11. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease

    PubMed Central

    Niroumand, Shabnam; Khajedaluee, Mohammad; Khadem-Rezaiyan, Majid; Abrishami, Maryam; Juya, Mohammadreza; Khodaee, Gholamhasan; Dadgarmoghaddam, Maliheh

    2015-01-01

    Background: Cardiovascular disease (CVD) is the cause of one third of deaths worldwide and this will progress because of increasing CVD's risk factors. The most basic task of dealing with the epidemic of CVD is primary prevention of risk factors. As Atherogenic Index of Plasma (AIP) is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the correlation between AIP and other important factors. Methods: This cross-sectional study was a part of national non-communicable risk factors surveillance system data that has been established since 2004 in Iran. This was done on 1000 people between 2008 and 2010. The study was approved by Ethics Committee of Mashhad University of Medical Science. Chi square, Mann-Whitney U, correlation tests were used in this study. Statistical analysis was performed using SPSS version 11. In all calculations, p <0.05 was considered as statistically significant level. Results: The study population consisted of 500 men and 500 women with mean±SD age 41.9±14.2 years. According to the AIP category, 9.8% (98) were in low risk group, 12.7% (127) were in intermediate risk and 77.5% (775) were in increased risk of CVD. AIP was significantly correlated with waist circumference (r=0.35, p<0.001), BMI (r=0.33, p<0.001) and physical activity (r=-0.09, p<0.01). Conclusion: AIP can be used as a regular monitoring index of CVD in every day practice, especially in persons with other cardiovascular risk factors. PMID:26793631

  12. Using SAS PROC MCMC for Item Response Theory Models

    ERIC Educational Resources Information Center

    Ames, Allison J.; Samonte, Kelli

    2015-01-01

    Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian…

  13. A Note on Multigroup Comparisons Using SAS PROC CALIS

    ERIC Educational Resources Information Center

    Jones-Farmer, L. Allison; Pitts, Jennifer P.; Rainer, R. Kelly

    2008-01-01

    Although SAS PROC CALIS is not designed to perform multigroup comparisons, it is believed that SAS can be "tricked" into doing so for groups of equal size. At present, there are no comprehensive examples of the steps involved in performing a multigroup comparison in SAS. The purpose of this article is to illustrate these steps. We demonstrate…

  14. Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

    PubMed

    Scudder, C J; Niessen, S J; Catchpole, B; Fowkes, R C; Church, D B; Forcada, Y

    2017-04-01

    Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human acromegalic families with AIP mutations. The aim of this study was to sequence the feline AIP gene, identify sequence variants and compare the AIP gene sequence between feline acromegalic and control cats, and in acromegalic siblings. The feline AIP gene was amplified through PCR using whole blood genomic DNA from 10 acromegalic and 10 control cats, and 3 sibling pairs affected by acromegaly. PCR products were sequenced and compared with the published predicted feline AIP gene. A single nonsynonymous SNP was identified in exon 1 (AIP:c.9T > G) of two acromegalic cats and none of the control cats, as well as both members of one sibling pair. The region of this SNP is considered essential for the interaction of the AIP protein with its receptor. This sequence variant has not previously been reported in humans. Two additional synonymous sequence variants were identified (AIP:c.481C > T and AIP:c.826C > T). This is the first molecular study to investigate a potential genetic cause of feline acromegaly and identified a nonsynonymous AIP single nucleotide polymorphism in 20% of the acromegalic cat population evaluated, as well as in one of the sibling pairs evaluated.

  15. ConfChem Conference on Flipped Classroom: Using a Blog to Flip a Classroom

    ERIC Educational Resources Information Center

    Haile, January D.

    2015-01-01

    This communication summarizes one of the invited papers to the Flipped Classroom ACS Division of Chemical Education Committee on Computers in Chemical Education online ConfChem held from May 18 to June 24, 2014. Just in Time Teaching is a technique in which students read the material before class and respond to a few questions. In a first-year…

  16. An AIPS++ Commissioning Tool for the Green Bank Telescope

    NASA Astrophysics Data System (ADS)

    Braatz, J.; McMullin, J.; Garwood, R.; Maddalena, R.; Norrod, R.

    1999-12-01

    The Green Bank Telescope (GBT) is a 100-m diameter antenna with an unblocked aperture and an active surface. It is designed to observe at frequencies from 300 MHz to 100 GHz. Construction of the telescope is now in the final phase - installation of the surface panels - and will be completed in early 2000. The electronics systems for the telescope have been under development and testing in a "Mock-up" which includes the receivers, LO systems, analog filters, and the backends. Upon completion of construction, the telescope will undergo a series of commissioning procedures to prepare for general astronomical observing. We will illustrate the software tools being developed in support of the engineering tests and commissioning requirements of the GBT. These requirements include analysis of holography data, which will be used to measure the initial surface accuracy of the dish. This software is being developed in the AIPS++ programming environment using Glish, a powerful scripting language adopted by the AIPS++ system.

  17. Familial pituitary adenomas - who should be tested for AIP mutations?

    PubMed

    Korbonits, Márta; Storr, Helen; Kumar, Ajith V

    2012-09-01

    Familial Isolated Pituitary Adenomas (FIPA), an autosomal dominant disease with low penetrance is being increasingly recognized. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. Patients with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are characterized by young-onset somatotroph or lactotroph macroadenomas, while in the other, larger group of FIPA patients with typically adult-onset disease and more varied adenoma types, no causative gene(s) has been identified. Young-onset macroadenoma patients can also be identified with germline AIP mutation without an apparent family history. Further data and longer follow-up are necessary to establish formal guidelines, but the current data suggest genetic screening of the AIP gene in patients with a pituitary adenoma and no other associated features who have (i) a family history of pituitary adenoma, (ii) childhood-onset pituitary adenoma or (iii) a pituitary somatotroph or lactotroph macroadenoma diagnosed before the age of 30 years.

  18. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

    PubMed

    Hassan, Wail M; Merin, David A; Fonte, Virginia; Link, Christopher D

    2009-08-01

    Multiple neurodegenerative diseases are causally linked to aggregation-prone proteins. Cellular mechanisms involving protein turnover may be key defense mechanisms against aggregating protein disorders. We have used a transgenic Caenorhabditis elegans Alzheimer's disease model to identify cellular responses to proteotoxicity resulting from expression of the human beta amyloid peptide (Abeta). We show up-regulation of aip-1 in Abeta-expressing animals. Mammalian homologues of AIP-1 have been shown to associate with, and regulate the function of, the 26S proteasome, leading us to hypothesize that induction of AIP-1 may be a protective cellular response directed toward modulating proteasomal function in response to toxic protein aggregation. Using our transgenic model, we show that overexpression of AIP-1 protected against, while RNAi knockdown of AIP-1 exacerbated, Abeta toxicity. AIP-1 overexpression also reduced accumulation of Abeta in this model, which is consistent with AIP-1 enhancing protein degradation. Transgenic expression of one of the two human aip-1 homologues (AIRAPL), but not the other (AIRAP), suppressed Abeta toxicity in C. elegans, which advocates the biological relevance of the data to human biology. Interestingly, AIRAPL and AIP-1 contain a predicted farnesylation site, which is absent from AIRAP. This farnesylation site was shown by others to be essential for an AIP-1 prolongevity function. Consistent with this, we show that an AIP-1 mutant lacking the predicted farnesylation site failed to protect against Abeta toxicity. Our results implicate AIP-1 in the regulation of protein turnover and protection against Abeta toxicity and point at AIRAPL as the functional mammalian homologue of AIP-1.

  19. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.

    PubMed

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-08-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15-40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and beta-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6+/-11.2 years) than AIP mutation-negative patients (40.4+/-14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein-protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants.

  20. Characterization of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Mutations in Familial Isolated Pituitary Adenoma Families

    PubMed Central

    Igreja, Susana; Chahal, Harvinder S; King, Peter; Bolger, Graeme B; Srirangalingam, Umasuthan; Guasti, Leonardo; Chapple, J Paul; Trivellin, Giampaolo; Gueorguiev, Maria; Guegan, Katie; Stals, Karen; Khoo, Bernard; Kumar, Ajith V; Ellard, Sian; Grossman, Ashley B; Korbonits, Márta

    2010-01-01

    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15–40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and β-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6±11.2 years) than AIP mutation-negative patients (40.4±14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein–protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants. Hum Mutat 31:1–11, 2010. © 2010 Wiley-Liss, Inc. PMID:20506337

  1. PROC LCA: A SAS Procedure for Latent Class Analysis.

    PubMed

    Lanza, Stephanie T; Collins, Linda M; Lemmon, David R; Schafer, Joseph L

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across groups can be empirically tested. LCA with covariates extends the model to include predictors of class membership. In this article, we introduce PROC LCA, a new SAS procedure for conducting LCA, multiple-group LCA, and LCA with covariates. The procedure is demonstrated using data on alcohol use behavior in a national sample of high school seniors.

  2. An analysis of six cases of acute intermittent porphyria (AIP)

    PubMed Central

    Ghosh, Soumitra; Chaudhury, Pranit KR.; Goswami, Hiranya K.

    2006-01-01

    This analysis describes the diagnosis and psychiatric treatment modalities of 6 patients (5 women, 1 man; mean age 28.5 years) of acute intermittent porphyria (AIP), who presented to the Psychiatry OPD over a period of one year. The mean number of episodes was 2.83. Premorbid personality traits, clinical presentation, urine colour and urinary porphobilinogen titre were recorded. Among the 6 patients, 4 had abdominal pain, 5 had autonomic instability, all 6 had mental symptoms, 3 had depression, 2 came in delirium, and 3 had an episode of seizure. PMID:20844651

  3. Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

    PubMed

    Lecoq, Anne-Lise; Zizzari, Philippe; Hage, Mirella; Decourtye, Lyvianne; Adam, Clovis; Viengchareun, Say; Veldhuis, Johannes D; Geoffroy, Valérie; Lombès, Marc; Tolle, Virginie; Guillou, Anne; Karhu, Auli; Kappeler, Laurent; Chanson, Philippe; Kamenický, Peter

    2016-10-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip(+/-)) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of Aip(+/-) mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12 months of age. As the early stages of pituitary tumorigenesis are controversial, we also studied the pituitary histology and somatotroph cell proliferation in these mice. Aip(+/-) mice did not develop gigantism but exhibited a leaner phenotype than wild-type mice. Analysis of GH pulsatility by deconvolution in 12-month-old Aip(+/-) mice showed a mild increase in total GH secretion, a conserved GH pulsatility pattern, but a normal IGF1 concentration. No pituitary adenomas were detected up to 12 months of age. An increased ex vivo response to GHRH of pituitary explants from 3-month-old Aip(+/-) mice, together with areas of enlarged acini identified on reticulin staining in the pituitary of some Aip(+/-) mice, was suggestive of somatotroph hyperplasia. Global heterozygous Aip deficiency in mice is accompanied by subtle increase in GH secretion, which does not result in gigantism. The absence of pituitary adenomas in 12-month-old Aip(+/-) mice in our experimental conditions demonstrates the important phenotypic variability of this congenic mouse model.

  4. Aip regulates cAMP signalling and GH secretion in GH3 cells.

    PubMed

    Formosa, R; Xuereb-Anastasi, A; Vassallo, J

    2013-08-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked to predisposition to pituitary adenomas. However, the mechanism by which this occurs remains unknown. AIP interacts with a number of interesting proteins, including members of the cAMP signalling pathway that has been shown to be consistently altered in pituitary tumours. The functional role of Aip was investigated using both over-expression and knock down of Aip in GH3 cells. cAMP signalling and its downstream effectors, including GH secretion, were then investigated. cAMP signalling was analysed using cAMP assays, cAMP-response element-promoter luciferase reporter assays, real-time PCR and finally secreted GH quantification. Over-expression of wild-type (WT)-Aip reduced forskolin-induced cAMP signalling at the total cAMP level, luciferase reporter activity and target gene expression, when compared with empty vector and the non-functional R304X mutant. Additionally, GH secretion was reduced in WT-Aip over-expressing GH3 cells treated with forskolin. Knock down of endogenous Aip resulted in increased cAMP signalling but a decrease in GH secretion was also noted. Inhibition of phosphodiesterase activity using general and selective inhibitors did not completely ablate the effect of Aip on forskolin-augmented cAMP signalling. A mechanism by which Aip acts as a tumour suppressor, by maintaining a low cAMP signalling and concentration, is suggested. Mutations of Aip render the protein incapable of such activity. This effect appears not to be mediated by the AIP-PDE interaction, suggesting the involvement of other interacting partners in mediating this outcome.

  5. AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.

    PubMed

    Tuominen, I; Heliövaara, E; Raitila, A; Rautiainen, M-R; Mehine, M; Katainen, R; Donner, I; Aittomäki, V; Lehtonen, H J; Ahlsten, M; Kivipelto, L; Schalin-Jäntti, C; Arola, J; Hautaniemi, S; Karhu, A

    2015-02-26

    The aryl hydrocarbon receptor interacting protein (AIP) is a tumor-suppressor gene underlying the pituitary adenoma predisposition. Thus far, the exact molecular mechanisms by which inactivated AIP exerts its tumor-promoting action have been unclear. To better understand the role of AIP in pituitary tumorigenesis, we performed gene expression microarray analysis to examine changes between Aip wild-type and knockout mouse embryonic fibroblast (MEF) cell lines. Transcriptional analyses implied that Aip deficiency causes a dysfunction in cyclic adenosine monophosphate (cAMP) signaling, as well as impairments in signaling cascades associated with developmental and immune-inflammatory responses. In vitro experiments showed that AIP deficiency increases intracellular cAMP concentrations in both MEF and murine pituitary adenoma cell lines. Based on knockdown of various G protein α subunits, we concluded that AIP deficiency leads to elevated cAMP concentrations through defective Gαi-2 and Gαi-3 proteins that normally inhibit cAMP synthesis. Furthermore, immunostaining of Gαi-2 revealed that AIP deficiency is associated with a clear reduction in Gαi-2 protein expression levels in human and mouse growth hormone (GH)-secreting pituitary adenomas, thus indicating defective Gαi signaling in these tumors. By contrast, all prolactin-secreting tumors showed prominent Gαi-2 protein levels, irrespective of Aip mutation status. We additionally observed reduced expression of phosphorylated extracellular signal-regulated kinases 1/2 and cAMP response element-binding protein levels in mouse and human AIP-deficient somatotropinomas. This study implies for the first time that a failure to inhibit cAMP synthesis through dysfunctional Gαi signaling underlies the development of GH-secreting pituitary adenomas in AIP mutation carriers.

  6. Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations.

    PubMed

    Jaffrain-Rea, Marie-Lise; Rotondi, Sandra; Turchi, Annarita; Occhi, Gianluca; Barlier, Anne; Peverelli, Erika; Rostomyan, Lilya; Defilles, Céline; Angelini, Mariolina; Oliva, Maria-Antonietta; Ceccato, Filippo; Maiorani, Orlando; Daly, Adrian F; Esposito, Vincenzo; Buttarelli, Francesca; Figarella-Branger, Dominique; Giangaspero, Felice; Spada, Anna; Scaroni, Carla; Alesse, Edoardo; Beckers, Albert

    2013-10-01

    Germline aryl hydrocarbon receptor interacting protein (AIP) gene mutations confer a predisposition to pituitary adenoma (PA), predominantly GH-secreting (GH-PA). As recent data suggest a role for AIP in the pathogenesis of sporadic GH-PA and their response to somatostatin analogues (SSA), the expression of AIP and its partner, aryl hydrocarbon receptor (AHR), was determined by semiquantitative immunohistochemistry scoring in 62 sporadic GH-PA (37 treated with SSA preoperatively). The influence of Gsp status was studied in a subset of tumours (n=39, 14 Gsp(+)) and six GH-PA were available for primary cultures. AIP and AHR were detected in most cases, with a positive correlation between AIP and cytoplasmic AHR (P=0.012). Low AIP expression was significantly more frequent in untreated vs SSA-treated tumours (44.0 vs 20.5%, P=0.016). AHR expression or localisation did not differ between the two groups. Similarly, in vitro octreotide induced a median twofold increase in AIP expression (range 1.2-13.9, P=0.027) in GH-PA. In SSA-treated tumours, the AIP score was significantly higher in the presence of preoperative IGF1 decrease or tumour shrinkage (P=0.008 and P=0.014 respectively). In untreated tumours, low AIP expression was significantly associated with invasiveness (P=0.028) and suprasellar extension (P=0.019). The only effect of Gsp status was a significantly lower nuclear AHR score in Gsp(+) vs Gsp(-) tumours (P=0.025), irrespective of SSA. In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.

  7. Current Concepts and Diagnosis of IgG4-Related Pancreatitis (Type 1 AIP).

    PubMed

    Kawa, Shigeyuki

    2016-08-01

    Although now considered to be a member of the systemic entity of immunoglobulin G4- (IgG4-) related disease, IgG4-related pancreatitis is generally referred to as type 1 autoimmune pancreatitis (AIP). Type 1 AIP was established based on a pathological background of lymphoplasmacytic sclerosing pancreatitis, high serum IgG4 concentration, and abundant IgG4-bearing plasma cell infiltration. The characteristic clinical features of type 1 AIP, such as elderly male preponderance, obstructive jaundice, and mass-forming lesions in the pancreas, often mimic those of pancreatic cancer. However, because AIP responds favorably to corticosteroid treatment, careful differentiation from pancreatic cancer is required. An AIP diagnosis is currently based on the 2011 International Consensus Diagnostic Criteria for AIP, which are based on high sensitivity, selectivity, and accuracy. Over the long term, AIP can progress to a chronic condition, with pancreatic stone formation and atrophy resembling that of chronic pancreatitis. Although AIP has been linked to the complication of malignancies, it remains controversial whether an association exists between the disease and tumor formation.

  8. 75 FR 5846 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... available under Public Law No. 111-117 to accomplish Airport Improvement Program (AIP)-eligible...

  9. 75 FR 3954 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal Aviation... Program (AIP)-eligible projects that the sponsor previously identified through the Airports Capital... AIP authorization and an extension of the FAA's spending authority from the Airport and Airway...

  10. 76 FR 6178 - Deadline for Notification of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement... under Public Law 111-322 to accomplish Airport Improvement Program (AIP)-eligible projects that the... without a legislative enactment that provides an additional AIP authorization and an extension of the...

  11. 77 FR 19408 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2012 AGENCY: Federal Aviation... Airport Improvement Program (AIP)-eligible projects that the sponsor previously identified through the... promulgated to expedite and prioritize the grant- making process. The AIP grant program is operating under...

  12. 78 FR 20167 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2013 AGENCY: Federal Aviation... Airport Improvement Program (AIP)-eligible projects that the sponsor previously identified through the... prioritize the grant- making process. The AIP grant program is operating under the requirements of Public...

  13. BCL::Conf: small molecule conformational sampling using a knowledge based rotamer library.

    PubMed

    Kothiwale, Sandeepkumar; Mendenhall, Jeffrey L; Meiler, Jens

    2015-01-01

    The interaction of a small molecule with a protein target depends on its ability to adopt a three-dimensional structure that is complementary. Therefore, complete and rapid prediction of the conformational space a small molecule can sample is critical for both structure- and ligand-based drug discovery algorithms such as small molecule docking or three-dimensional quantitative structure-activity relationships. Here we have derived a database of small molecule fragments frequently sampled in experimental structures within the Cambridge Structure Database and the Protein Data Bank. Likely conformations of these fragments are stored as 'rotamers' in analogy to amino acid side chain rotamer libraries used for rapid sampling of protein conformational space. Explicit fragments take into account correlations between multiple torsion bonds and effect of substituents on torsional profiles. A conformational ensemble for small molecules can then be generated by recombining fragment rotamers with a Monte Carlo search strategy. BCL::Conf was benchmarked against other conformer generator methods including Confgen, Moe, Omega and RDKit in its ability to recover experimentally determined protein bound conformations of small molecules, diversity of conformational ensembles, and sampling rate. BCL::Conf recovers at least one conformation with a root mean square deviation of 2 Å or better to the experimental structure for 99 % of the small molecules in the Vernalis benchmark dataset. The 'rotamer' approach will allow integration of BCL::Conf into respective computational biology programs such as Rosetta.Graphical abstract:Conformation sampling is carried out using explicit fragment conformations derived from crystallographic structure databases. Molecules from the database are decomposed into fragments and most likely conformations/rotamers are used to sample correspondng sub-structure of a molecule of interest.

  14. AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.

    PubMed

    Lecoq, Anne-Lise; Viengchareun, Say; Hage, Mirella; Bouligand, Jérôme; Young, Jacques; Boutron, Audrey; Zizzari, Philippe; Lombès, Marc; Chanson, Philippe; Kamenický, Peter

    2016-05-01

    Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenobiotics implicated in carcinogenesis. As 75% of AIP mutations disrupt the physical and/or functional interaction with AhR, we postulated that the tumorigenic potential of AIP mutations might result from altered AhR signaling. We evaluated the impact of AIP mutations on the AhR signaling pathway, first in fibroblasts from AIP-mutated patients with pituitary adenomas, by comparison with fibroblasts from healthy subjects, then in transfected pituitary GH3 cells. The AIP protein level in mutated fibroblasts was about half of that in cells from healthy subjects, but AhR expression was unaffected. Gene expression analyses showed significant modifications in the expression of the AhR target genes CYP1B1 and AHRR in AIP-mutated fibroblasts, both before and after stimulation with the endogenous AhR ligand kynurenine. Kynurenine increased Cyp1b1 expression to a greater extent in GH3 cells overexpressing wild type compared with cells expressing mutant AIP Knockdown of endogenous Aip in these cells attenuated Cyp1b1 induction by the AhR ligand. Both mutant AIP expression and knockdown of endogenous Aip affected the kynurenine-dependent GH secretion of GH3 cells. This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR transcriptional activity in a gene- and tissue-dependent manner.

  15. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.

    PubMed

    Ferguson, Annabel A; Springer, Mitchell G; Fisher, Alfred L

    2010-06-01

    Maintenance of a stable, properly folded, and catalytically active proteome is a major challenge to organisms in the face of multiple internal and external stresses which damage proteins and lead to protein misfolding. Here we show that internal metabolic stress produced by reactive intermediates resulting from tyrosine degradation triggers the expression of the aip-1 gene, which is critical in responses to the environmental toxin arsenic and the clearance of unstable polyglutamine and Abeta proteins. aip-1 acts via binding to the proteosome and enhancing proteosomal function. We find that full induction of aip-1 depends on the oxidative-stress-responsive skn-1 transcription factor but significant induction still occurs without skn-1. Importantly, activation of skn-1 with wdr-23(RNAi), which dramatically induces the expression of other skn-1 target genes, produces a minimal increase in aip-1 expression. This suggests that the previously demonstrated specificity in aip-1/AIRAP induction could reflect the actions of multiple synergistic activators, such as the heat shock factor homolog hsf-1, which we also find is required for full induction. These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways.

  16. Identification and expression of mutations in the hydroxymethylbilane synthase gene causing acute intermittent porphyria (AIP).

    PubMed Central

    Solis, C.; Lopez-Echaniz, I.; Sefarty-Graneda, D.; Astrin, K. H.; Desnick, R. J.

    1999-01-01

    BACKGROUND: Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme hydroxymethylbilane synthase (EC 4.3.1.8; HMB-synthase). This disease is characterized by acute, life-threatening neurologic attacks that are precipitated by various drugs, hormones, and other factors. The enzymatic and/or biochemical diagnosis of AIP heterozygotes is problematic; therefore, efforts have focused on the identification of HMB-synthase mutations so that heterozygotes can be identified and educated to avoid the precipitating factors. In Spain, the occurrence of AIP has been reported, but the nature of the HMB-synthase mutations causing AIP in Spanish families has not been investigated. Molecular analysis was therefore undertaken in nine unrelated Spanish AIP patients. MATERIALS AND METHODS: Genomic DNA was isolated from affected probands and family members of nine unrelated Spanish families with AIP. The HMB-synthase gene was amplified by long-range PCR and the nucleotide sequence of each exon was determined by cycle sequencing. RESULTS: Three new mutations, a missense, M212V; a single base insertion, g4715insT; and a deletion/insertion, g7902ACT-->G, as well as five previously reported mutations (G111R, R116W, R149X R167W, and R173W) were detected in the Spanish probands. Expression of the novel missense mutation M212V in E. coli revealed that the mutation was causative, having <2% residual activity. CONCLUSIONS: These studies identified the first mutations in the HMB-synthase gene causing AIP in Spanish patients. Three of the mutations were novel, while five previously reported lesions were found in six Spanish families. These findings enable accurate identification and counseling of presymptomatic carriers in these nine unrelated Spanish AIP families and further demonstrate the genetic heterogeneity of mutations causing AIP. Images Fig. 1 PMID:10602775

  17. Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Daly, Adrian F; Beckers, Albert

    2015-03-01

    The most frequent conditions that are associated with inherited/familial pituitary adenomas are familial isolated pituitary adenoma (FIPA) and multiple endocrine neoplasia type 1 (MEN1), which together account for up to 5% of pituitary adenomas. One important genetic cause of FIPA are inactivating mutations or deletions in the aryl hydrocarbon receptor interacting protein (AIP) gene. FIPA is the most frequent clinical presentation of AIP mutations. This article traces the current state of knowledge regarding the clinical features of FIPA and the particular genetic, pathologic, and clinical characteristics of pituitary adenomas due to AIP mutations.

  18. A Bayesian Analysis of Scale-Invariant Processes

    DTIC Science & Technology

    2012-01-01

    Analysis of Scale-Invariant Processes Jingfeng Wang, Rafael L. Bras, Veronica Nieves Georgia Tech Research Corporation Office of Sponsored Programs...processes Veronica Nieves , Jingfeng Wang, and Rafael L. Bras Citation: AIP Conf. Proc. 1443, 56 (2012); doi: 10.1063/1.3703620 View online: http...http://proceedings.aip.org/about/rights_permissions A Bayesian Analysis of Scale-Invariant Processes Veronica Nieves ∗, Jingfeng Wang† and Rafael L. Bras

  19. 77 FR 51948 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... Federal Aviation Administration 14 CFR Chapter 1 Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property; Correction AGENCY: Federal Aviation Administration (FAA... paragraph in the Proposed Policy Regarding Access to Airports From Residential Property that was...

  20. 76 FR 15028 - Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... Federal Aviation Administration Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential Property AGENCY: Federal Aviation Administration (FAA). ACTION: Interim policy; amendment to sponsor grant assurance 5. SUMMARY: This action adopts an interim policy amending...

  1. Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening.

    PubMed

    Pinho, Leandro Kasuki Jomori de; Vieira Neto, Leonardo; Wildemberg, Luiz Eduardo Armondi; Moraes, Aline Barbosa; Takiya, Christina M; Frohman, Lawrence A; Korbonits, Márta; Gadelha, Mônica R

    2010-11-01

    We present four FIPA kindred discussing clinical and molecular data and emphasizing the differences regarding AIP status, as well as the importance of genetic screening. Family 1 consists of five patients harboring somatotropinomas with germline E24X mutation in AIP. In one of the patients, acromegaly was diagnosed through active screening, being cured by surgery. Families 2 and 3 are composed of two patients with non-functioning pituitary adenomas. Family 4 comprises patients harboring a prolactinoma and a somatotropinoma. No mutations in AIP were found in these families. No patient in Family 1 was controlled with octreotide treatment, while the acromegalic patient in Family 4 was controlled with octreotide LAR. In conclusion, FIPA is a heterogeneous condition, which may be associated with AIP mutation. Genomic and clinical screening is recommended in families with two or more members harboring pituitary adenomas, allowing early diagnosis and better outcome.

  2. The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.

    PubMed

    Heliövaara, Elina; Raitila, Anniina; Launonen, Virpi; Paetau, Anders; Arola, Johanna; Lehtonen, Heli; Sane, Timo; Weil, Robert J; Vierimaa, Outi; Salmela, Pasi; Tuppurainen, Karoliina; Mäkinen, Markus; Aaltonen, Lauri A; Karhu, Auli

    2009-12-01

    Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to the development of pituitary adenomas. Here, we characterized AIP mutation positive (AIPmut+) and AIP mutation negative (AIPmut-) pituitary adenomas by immunohistochemistry. The expressions of the AIP-related proteins aryl hydrocarbon receptor (AHR), AHR nuclear translocator (ARNT), cyclin-dependent kinase inhibitor 1B encoding p27(Kip1), and hypoxia-inducible factor 1-alpha were examined in 14 AIPmut+ and 53 AIPmut- pituitary adenomas to detect possible expression differences. In addition, the expression of CD34, an endothelial and hematopoietic stem cell marker, was analyzed. We found ARNT to be less frequently expressed in AIPmut+ pituitary adenomas (P = 0.001), suggesting that AIP regulates the ARNT levels. AIP small interfering RNA-treated HeLa, HEK293, or Aip-null mouse embryonic fibroblast cells did not show lowered expression of ARNT. Instead, in the pituitary adenoma cell line GH3, Aip silencing caused a partial reduction of Arnt and a clear increase in cell proliferation. We also observed a trend for increased expression of nuclear AHR in AIPmut+ samples, although the difference was not statistically significant (P = 0.06). The expressions of p27(Kip1), hypoxia-inducible factor 1-alpha, or CD34 did not differ between tumor types. The present study shows that the expression of ARNT protein is significantly reduced in AIPmut+ tumors. We suggest that the down-regulation of ARNT may be connected to an imbalance in AHR/ARNT complex formation arising from aberrant cAMP signaling.

  3. cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.

    PubMed

    Bolger, Graeme B; Bizzi, Mariana F; Pinheiro, Sergio V; Trivellin, Giampaolo; Smoot, Lisa; Accavitti, Mary-Ann; Korbonits, Márta; Ribeiro-Oliveira, Antonio

    2016-05-01

    PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore regulate numerous processes, including cell growth and differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations in AIP occur in approximately 20% of patients with Familial Isolated Pituitary Adenoma (FIPA) and 20% of childhood-onset simplex somatotroph adenomas. We therefore examined the protein expression of PDE4A4 and the closely related isoform PDE4A8 in normal human pituitary tissue and in pituitary adenomas. PDE4A4 had low expression in normal pituitary but was significantly overexpressed in somatotroph, lactotroph, corticotroph and clinically nonfunctioning gonadotroph adenomas (P<0.0001 for all subtypes). Likewise, PDE4A8 was expressed in normal pituitary and was also significantly overexpressed in the adenoma subtypes (P<0.0001 for all). Among the different adenoma subtypes, corticotroph and lactotroph adenomas were the highest and lowest expressed for PDE4A4, respectively, whereas the opposite was observed for PDE4A8. Naturally occurring oncogenic variants in AIP were shown by a two-hybrid assay to disrupt the ability of AIP to interact with PDE4A5. A reverse two-hybrid screen identified numerous additional variants in the tetratricopeptide repeat (TPR) region of AIP that also disrupted its ability to interact with PDE4A5. The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.

  4. AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.

    PubMed

    Fumoto, K; Lee, P-C; Saya, H; Kikuchi, A

    2008-07-24

    Glycogen synthase kinase-3 (GSK-3beta) regulates microtubule dynamics and cellular polarity through phosphorylating various microtubule associating proteins and plus-end tracking proteins. Although it was also reported that GSK-3beta is inactivated by protein kinase B at the spindle poles, functions and targets of GSK-3beta in the mitotic phase are unknown. Here, we identified Aurora-A-interacting protein (AIP), a negative regulator of Aurora-A, as a binding partner of GSK-3beta. AIP was colocalized with Aurora-A and GSK-3beta to the spindle poles in metaphase, and its depletion in cells stabilized and activated Aurora-A in early mitotic phase and caused mitotic cell arrest. Treatment of the cells with a GSK-3beta inhibitor reduced the protein level of Aurora-A and this reduction was suppressed by AIP knockdown. AIP was phosphorylated by GSK-3beta, and an AIP mutant in which the GSK-3beta phosphorylation site was mutated could bind and downregulate Aurora-A more efficiently. These results suggest that GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.

  5. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

    PubMed

    Johnson, Jeffrey G; Wang, Boyuan; Debelouchina, Galia T; Novick, Richard P; Muir, Tom W

    2015-05-04

    The agr locus in the commensal human pathogen, Staphylococcus aureus, is a two-promoter regulon with allelic variability that produces a quorum-sensing circuit involved in regulating virulence within the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentrations by AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global changes in gene expression. The finding that staphylococcal virulence can be inhibited through antagonism of this quorum-sensing pathway has fueled tremendous interest in understanding the structure-activity relationships underlying the AIP-AgrC interaction. The defining structural feature of the AIP is a 16-membered, thiolactone-containing macrocycle. Surprisingly, the importance of ring size on agr activation or inhibition has not been explored. In this study, we address this deficiency through the synthesis and functional analysis of AIP analogues featuring enlarged and reduced macrocycles. Notably, this study is the first to interrogate AIP function by using both established cell-based reporter gene assays and newly developed in vitro AgrC-I binding and autophosphorylation activity assays. Based on our data, we present a model for robust agr activation involving a cooperative, three-points-of-contact interaction between the AIP macrocycle and AgrC.

  6. Acute interstitial pneumonia (AIP): relationship to Hamman-Rich syndrome, diffuse alveolar damage (DAD), and acute respiratory distress syndrome (ARDS).

    PubMed

    Mukhopadhyay, Sanjay; Parambil, Joseph G

    2012-10-01

    Acute interstitial pneumonia (AIP) is a term used for an idiopathic form of acute lung injury characterized clinically by acute respiratory failure with bilateral lung infiltrates and histologically by diffuse alveolar damage (DAD), a combination of findings previously known as the Hamman-Rich syndrome. This review aims to clarify the diagnostic criteria of AIP, its relationship with DAD and acute respiratory distress syndrome (ARDS), key etiologies that need to be excluded before making the diagnosis, and the salient clinical features. Cases that meet clinical and pathologic criteria for AIP overlap substantially with those that fulfill clinical criteria for ARDS. The main differences between AIP and ARDS are that AIP requires a histologic diagnosis of DAD and exclusion of known etiologies. AIP should also be distinguished from "acute exacerbation of IPF," a condition in which acute lung injury (usually DAD) supervenes on underlying usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF).

  7. Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study.

    PubMed

    Ferraù, Francesco; Romeo, P D; Puglisi, S; Ragonese, M; Torre, M L; Scaroni, C; Occhi, G; De Menis, E; Arnaldi, G; Trimarchi, F; Cannavò, S

    2016-12-01

    This multicentric study aimed to investigate the prevalence of the G protein-coupled receptor 101 (GPR101) p.E308D variant and aryl hydrocarbon receptor interacting protein (AIP) gene mutations in a representative cohort of Italian patients with acromegaly. 215 patients with GH-secreting pituitary adenomas, referred to 4 Italian referral centres for pituitary diseases, have been included. Three cases of gigantism were present. Five cases were classified as FIPA. All the patients have been screened for germline AIP gene mutations and GPR101 gene p.E308D variant. Heterozygous AIP gene variants have been found in 7 patients (3.2 %). Five patients carried an AIP mutation (2.3 %; 4 females): 3 patients harboured the p.R3O4Q mutation, one had the p.R304* mutation and the last one the IVS3+1G>A mutation. The prevalence of AIP mutations was 3.3 % and 2.8 % when considering only the patients diagnosed when they were <30 or <40-year old, respectively. Furthermore, 2.0 % of the patients with a pituitary macroadenoma and 4.2 % of patients resistant to somatostatin analogues treatment were found to harbour an AIP gene mutation. None of the patients was found to carry the GPR101 p.E308D variant. The prevalence of AIP gene mutations among our sporadic and familial acromegaly cases was similar to that one reported in previous studies, but lower when considering only the cases diagnosed before 40 years of age. The GPR101 p.E308D change is unlikely to have a role in somatotroph adenomas tumorigenesis, since none of our sporadic or familial patients tested positive for this variant.

  8. [AIP mutations in familial and sporadic pituitary adenomas: local experience and review of the literature].

    PubMed

    Fajardo-Montañana, Carmen; Daly, Adrian F; Riesgo-Suárez, Pedro; Gómez-Vela, José; Tichomirowa, María A; Camara-Gómez, Rosa; Beckers, Albert

    2009-01-01

    Clinically relevant pituitary adenomas occur 3-5 times more frequently than previously thought. The majority are isolated cases, but their presentation can be familial in the setting of known syndromes such as multiple endocrine neoplasia (MEN)-1 and Carney complex. When 2 or more cases of pituitary adenomas occur in the same family in the absence of the above-mentioned syndromes, a diagnosis of FIPA (familial isolated pituitary adenomas) is made, which accounts for 1-2% of all pituitary adenomas. Mutations of the gene AIP (aryl hydrocarbon receptor-interacting protein) may account for 15% of FIPA families (50% of familial acromegaly), and as such the genetic causes continue to be studied. Also mutations in AIP can be detected in sporadic adenomas among young populations (< 30 years of age). We describe the characteristics of FIPA, detailing the study of a spanish family, in this case AIP mutation negative. Also, the reported findings in sporadic adenomas in the young population are detailed, accompanied by the description of a 19- year old patient with an intronic AIP mutation. Multicenter studies have provided understanding of aspects such as mutations in AIP; however, further studies are necessary to identify other genes involved in FIPA and sporadic pituitary adenomas occurring at a young age.

  9. Probabilistic Reverse dOsimetry Estimating Exposure Distribution (PROcEED)

    EPA Pesticide Factsheets

    PROcEED is a web-based application used to conduct probabilistic reverse dosimetry calculations.The tool is used for estimating a distribution of exposure concentrations likely to have produced biomarker concentrations measured in a population.

  10. Sustainable Management of Seagrass Meadows: the GEOSS AIP-6 Pilot

    NASA Astrophysics Data System (ADS)

    Santoro, Mattia; Pastres, Roberto; Zucchetta, Matteo; Venier, Chiara; Roncella, Roberto; Bigagli, Lorenzo; Mangin, Antoine; Amine Taji, Mohamed; Gonzalo Malvarez, Gonzalo; Nativi, Stefano

    2014-05-01

    Seagrass meadows (marine angiosperm plants) occupy less than 0.2% of the global ocean surface, annually store about 10-18% of the so-called "Blue Carbon", i.e. the Carbon stored in coastal vegetated areas. Recent literature estimates that the flux to the long-term carbon sink in seagrasses represents 10-20% of seagrasses global average production. Such figures can be translated into economic benefits, taking into account that a ton of carbon dioxide in Europe is paid at around 15 € in the carbon market. This means that the organic carbon retained in seagrass sediments in the Mediterranean is worth 138 - 1128 billion €, which represents 6-23 € per square meter. This is 9-35 times more than one square meter of tropical forest soil (0.66 € per square meter), or 5-17 times when considering both the above and the belowground compartments in tropical forests. According the most conservative estimations, about 10% of the Mediterranean meadows have been lost during the last century. To estimate seagrass meadows distribution, a Species Distribution Model (SDM) can be used. SDM is a tool that is used to evaluate the potential distribution of a given species (e.g. Posidonia oceanica for seagrass) on the basis of the features (bio-chemical-physical parameters) of the studied environment. In the framework of the GEOSS (Global Earth Observation System of Systems) initiative, the FP7 project MEDINA developed a showcase as part of the GEOSS Architecture Interoperability Pilot - phase 6 (AIP-6). The showcase aims at providing a tool for the sustainable management of seagrass meadows along the Mediterranean coastline by integrating the SDM with available GEOSS resources. This way, the required input data can be searched, accessed and ingested into the model leveraging the brokering framework of the GEOSS Common Infrastructure (GCI). This framework is comprised of a set of middle-ware components (Brokers) that are in charge of implementing the needed interoperability

  11. Design, construction and test of mercury thermometric cell in CENAMEP AIP

    NASA Astrophysics Data System (ADS)

    Ortega-Cortés, R.; Méndez-Lango, E.; Araolaza-Rodriguez, A.

    2013-09-01

    We present the results of the design, construction, filling and test of thermometric cell, to reproduce the triple point of mercury in the Temperature Laboratory of Centro Nacional de Metrología de Panamá AIP (CENAMEP AIP). This cell will be included in the group of thermometric cells of the laboratory. With this cell CENAMEP-AIP is covering the -39 °C to 660 °C range. This new cell offers the opportunity to reproduce the primary temperature defined by ITS-90 of -38.8344 ° C, and was built with 0.68 kg of mercury ultra-pure certified by the National Institute of Standards and Technology from United States (NIST-EEUU). The reproducibility obtained with thermometric cell of mercury is approximately one thousandth of kelvin (1 mK). This value satisfies according to current laboratory equipment.

  12. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene.

    PubMed

    Rowlands, J Craig; Urban, Jonathan D; Wikoff, Daniele Staskal; Budinsky, Robert A

    2011-01-01

    The human aryl hydrocarbon receptor (AHR) is a protein for which there is little evidence of polymorphic variability of functional consequence. It has been hypothesized that potential variability in dioxin sensitivity may be due to polymorphisms in AHR-associated proteins, such as the human AHR-interacting protein (AIP). There are limited data on AIP single nucleotide polymorphisms (SNPs) with potential functional consequences. We sequenced 103 human DNA samples within the open reading frames of the AIP locus using samples from six ethnic populations to further characterize AIP SNPs. Eight exonic SNPs were identified at the AIP locus, including three novel SNPs: T48T, L212L, and V302V. Combined with prior reports, there are now a total of 14 exonic SNPs that have been identified within AIP. Of these, six are non-synonymous and are therefore of potential functional importance, though only two of these (Q228K and A276V) were detected in the current study. The functional consequences of Q228K and A276V are unknown, although functional evidence from AIP SNPs associated with congenital pituitary tumors suggests that such amino acid changes are likely to have no effect or to decrease, rather than increase, sensitivity to dioxins. To date, no non-synonymous SNPs have been detected in the AHR-binding region of AIP.

  13. Should aip gene screening be recommended in family members of FIPA patients with R16H variant?

    PubMed

    Zatelli, Maria Chiara; Torre, Maria Luisa; Rossi, Rachele; Ragonese, Marta; Trimarchi, Francesco; degli Uberti, Ettore; Cannavò, Salvatore

    2013-06-01

    Germline mutations of aryl-hydrocarbon-receptor interacting protein (AIP) are associated with pituitary adenoma predisposition. They occur in 20 % of familial isolated pituitary adenoma (FIPA) and in about 3-5 % of sporadic pituitary adenomas, especially in early onset somatotropinomas and prolactinomas. Our aim was to evaluate the clinical and genetic features of a large Italian FIPA family, where an AIP variant was identified. AIP direct sequencing from genomic DNA was carried out in 16 available family members. AIP R16H carriers also underwent magnetic resonance imaging and hormonal assessments. AIP mutations were also searched in 16 patients with sporadic growth hormone-secreting pituitary adenoma and in 6 unrelated patients in whom pituitary adenoma was excluded. We found an AIP R16H variation in two family members harbouring a pituitary adenoma and in 6 unaffected family members. No AIP mutation was found neither in growth hormone-secreting pituitary adenoma patients, nor in the unrelated patients without pituitary adenoma. We report a FIPA family harbouring an AIP R16H change, supporting the hypothesis that the latter represents a variant of unknown significance.

  14. [The change of atherogenic index of plasma (AIP) level in type 2 diabetic pedigrees and the response of AIP to Acarbose or Glimepiride in therapy of type 2 diabetes mellitus].

    PubMed

    Yang, Bo; Tian, Haoming; Ren, Yan; Tong, Nanwei; Yu, Hongling; Han, Lingchuan; Ran, Xingwu

    2005-06-01

    The alterations in atherogenic index of plasma (AlP) in type 2 diabetic patients and their normoglycemic first-degree relatives (NFDR) were investigated, and the effects of Acarbose or Glimepiride on AIP in 99 type 2 diabetic patients were evaluated. Triglycerride (TG), total cholesterol, high density lipoprotein-cholesterol (HDL-C) levels were analyzed, and Log (TG/HDL-C) was calculated as AIP in 62 type 2 diabetic patients and their 67 NFDR from 29 type 2 diabetic pedigrees and in 45 healthy controls without family histories of diabetes. Also analyzed were the same parameters in 99 type 2 diabetic patients before and after therapy with Acarbose or Glimepiride. The results revealed that diabetic patients and their NFDR had significantly higher AIP than did the controls, whereas no significant differences were seen between diabetic patients and their NFDR. Positive correlation of AIP between type 2 diabetic patients and their offspring were observed (r = 0.241, P < 0.05). After 8 weeks therapy with Acarbose, the AIP of type 2 diabetic patients was decreased significantly, and no differences were observed for AIP levels in Glimepiride group although the AIP was lower when compared with the untreated level. As a significant inverse correlation of small dense low density lipoprotein (sdLDL) with AIP was confirmed, our data suggest that diabetic patients and their NFDR from type 2 diabetic pedigrees had significantly higher AIP than did controls; AIP could be decreased by therapy with Acarbose in type 2 diabetic patients; Glimepiride may bring potential benefit to type 2 diabetic patients by influencing sdLDL.

  15. Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

    PubMed

    Vasquez, Joseph K; Tal-Gan, Yftah; Cornilescu, Gabriel; Tyler, Kimberly A; Blackwell, Helen E

    2017-02-16

    The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mimetics of AIPs for use as chemical tools to study QS in S. aureus. Herein, we report new peptidomimetic AgrC receptor inhibitors based on a tail-truncated AIP-II peptide that have almost analogous inhibitory activities to the parent peptide. Structural comparison of one of these peptidomimetics to the parent peptide and a highly potent, all-peptide-derived, S. aureus agr inhibitor (AIP-III D4A) revealed a conserved hydrophobic motif and overall amphipathic nature. Our results suggest that the AIP scaffold is amenable to structural mimicry and minimization for the development of synthetic agr inhibitors.

  16. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1

    PubMed Central

    Costa, Luciana J; Chen, Nan; Lopes, Adriana; Aguiar, Renato S; Tanuri, Amilcar; Plemenitas, Ana; Peterlin, B Matija

    2006-01-01

    Background Nef is an accessory protein of primate lentiviruses, HIV-1, HIV-2 and SIV. Besides removing CD4 and MHC class I from the surface and activating cellular signaling cascades, Nef also binds GagPol during late stages of the viral replicative cycle. In this report, we investigated further the ability of Nef to facilitate the replication of HIV-1. Results To this end, first the release of new viral particles was much lower in the absence of Nef in a T cell line. Since the same results were obtained in the absence of the viral envelope using pseudo-typed viruses, this phenomenon was independent of CD4 and enhanced infectivity. Next, we found that Nef not only possesses a consensus motif for but also binds AIP1 in vitro and in vivo. AIP1 is the critical intermediate in the formation of multivesicular bodies (MVBs), which play an important role in the budding and release of viruses from infected cells. Indeed, Nef proliferated MVBs in cells, but only when its AIP1-binding site was intact. Finally, these functions of Nef were reproduced in primary macrophages, where the wild type but not mutant Nef proteins led to increased release of new viral particles from infected cells. Conclusion We conclude that by binding GagPol and AIP1, Nef not only proliferates MVBs but also contributes to the egress of viral particles from infected cells. PMID:16764724

  17. 75 FR 57829 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Federal Aviation Administration Airport Improvement Program (AIP): Policy Regarding Access to Airports... Proposed Policy Regarding Access to Airports From Residential Property that was published in the Federal... and clarify FAA policy concerning through-the-fence access to a Federally obligated airport from...

  18. 77 FR 44515 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Federal Aviation Administration 14 CFR Chapter I Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... policy, based on Federal law, concerning through-the-fence access to a federally obligated airport...

  19. School Board Improvement Plans in Relation to the AIP Model of Educational Accountability: A Content Analysis

    ERIC Educational Resources Information Center

    van Barneveld, Christina; Stienstra, Wendy; Stewart, Sandra

    2006-01-01

    For this study we analyzed the content of school board improvement plans in relation to the Achievement-Indicators-Policy (AIP) model of educational accountability (Nagy, Demeris, & van Barneveld, 2000). We identified areas of congruence and incongruence between the plans and the model. Results suggested that the content of the improvement…

  20. Resistance to octreotide LAR in acromegalic patients with high SSTR2 expression: analysis of AIP expression.

    PubMed

    Kasuki, Leandro; Colli, Leandro M; Elias, Paula C L; Castro, Margaret de; Gadelha, Mônica R

    2012-11-01

    We present here the clinical and molecular data of two patients with acromegaly treated with octreotide LAR after non-curative surgery, and who presented different responses to therapy. Somatostatin receptor type 2 and 5 (SSTR2 and SSTR5), and aryl hydrocarbon receptor-interacting protein (AIP) expression levels were analyzed by qPCR. In both cases, high SSTR2 and low SSTR5 expression levels were detected; however, only one of the patients achieved disease control after octreotide LAR therapy. When we analyzed AIP expression levels of both cases, the patient whose disease was controlled after therapy exhibited AIP expression levels that were two times higher than the patient whose disease was still active. These two cases illustrate that, although the currently available somatostatin analogs bind preferentially to SSTR2, some patients are not responsive to therapy despite high expression of this receptor. This difference could be explained by differences in post-receptor signaling pathways, including the recently described involvement of AIP.

  1. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity

    PubMed Central

    Kiefer, Christian S.; Claes, Andrea R.; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity. PMID:25428588

  2. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    PubMed

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.

  3. Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP.

    PubMed

    Kamisawa, Terumi; Okazaki, Kazuichi; Kawa, Shigeyuki; Shimosegawa, Tooru; Tanaka, Masao

    2010-05-01

    Steroid therapy appeared to be a standard treatment for autoimmune pancreatitis (AIP), although some AIP patients improve spontaneously. The indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, and back pain, and the presence of symptomatic extrapancreatic lesions. Before steroid therapy, jaundice should be managed by biliary drainage in patients with obstructive jaundice, and blood glucose levels should be controlled in patients with diabetes mellitus. For the initial oral prednisolone dose for induction of remission, 0.6 mg/kg/day is recommended. The initial dose is administered for 2-4 weeks, and the dose is tapered by 5 mg every 1-2 weeks, based on changes in the clinical manifestations, biochemical blood tests (such as liver enzymes and IgG or IgG4 levels), and repeated imaging findings (US, CT, MRCP, ERCP, etc.). The dose is tapered to a maintenance dose (2.5-5 mg/day) over a period of 2-3 months. Steroid therapy should be stopped based on the disease activity in each case. Stopping of maintenance therapy should be planned within at least 3 years in cases with radiological and serological improvement. Re-administration or dose-up of steroid is effective for treating AIP relapses. The prognosis of AIP appears to be good over the short-term with steroid therapy. It is unclear whether the long-term outcome is good because there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy.

  4. The AIP (aryl hydrocarbon receptor-interacting protein) gene and its relation to the pathogenesis of pituitary adenomas.

    PubMed

    Lloyd, Catrin; Grossman, Ashley

    2014-08-01

    Pituitary adenomas are monoclonal neoplasms that may secrete excessive quantities of their endogenous hormones, or may not be associated with any obvious syndrome, in which case they are known as non-functioning pituitary adenomas. Around 2 % have been said to occur in a familial setting, in the absence of any other tumor, now described as familial isolated pituitary adenomas (FIPA). Some 15-30 % of such families harbor inactivating germ-line mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene, along with 20 % of pediatric seemingly sporadic cases. AIP mutants are referred to as having pituitary adenoma predisposition, and present with early onset, aggressive macroadenomas, most of which secrete somatotropin. Evidence from transfection studies implies that AIP acts as a tumor suppressor; although whether this is mediated through an interaction with the aryl hydrocarbon receptor, phosphodiesterases, or with cell cycle regulators such as survivin or RET remains controversial. However, at present an interaction with the cyclic AMP pathway seems most plausible. Recently, evidence has shown that AIP may act at the cell surface, causing changes in integrin function. The presence of AIP mutations in a significant proportion of FIPA families as well as in apparently sporadic cases, particularly in young patients, suggests a need to screen such patients for AIP mutations to enable better clinical management. However, the absence of AIP mutations in over half of such cases highlights the need to search for further gene mutations.

  5. Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort.

    PubMed

    Niyazoglu, Mutlu; Sayitoglu, Muge; Firtina, Sinem; Hatipoglu, Esra; Gazioglu, Nurperi; Kadioglu, Pinar

    2014-06-01

    Aryl hydrocarbon receptor-interacting protein (AIP) is associated with 15-20% of familial isolated pituitary adenomas and 50-80% of cases with AIP mutation exhibit a somatotropinoma. Herein we report clinical characteristics of a large family where AIP R304X variants have been identified. AIP mutation analysis was performed on a large (n = 52) Turkish family across six generations. Sella MRIs of 30 family members were obtained. Basal pituitary hormone levels were evaluated in 13 family members harboring an AIP mutation. Thirteen of 52 family members (25%) were found to have a heterozygous nonsense germline R304X mutation in the AIP gene. Seven of the 13 mutation carriers (53.8%) had current or previous history of pituitary adenoma. Of these 7 mutation carriers, all but one had somatotropinoma/somatolactotropinoma (85.7% of the pituitary adenomas). Of the 6 acromegaly patients with AIP mutation (F/M: 3/3) the mean age at diagnosis of acromegaly was 32 ± 10.3 years while the mean age of symptom onset was 24.8 ± 9.9 years. Three of the six (50%) acromegaly cases with AIP mutation within the family presented with a macroadenoma and none presented with gigantism. Biochemical disease control was achieved in 66.6% (4/6) of the mutation carriers with acromegaly after a mean follow-up period of 18.6 ± 17.6 years. Common phenotypic characteristics of familial pituitary adenoma or somatotropinoma due to AIP mutation vary between families or even between individuals within a family.

  6. Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation.

    PubMed

    van der Spuy, J; Cheetham, M E

    2004-08-01

    Mutations in the AIPL1 (aryl hydrocarbon receptor interacting protein-like 1) cause the blinding disease Leber's congenital amaurosis. AIPL1 is a homologue of the AIP. AIP functions as part of a chaperone heterocomplex to facilitate signalling by the AhR and plays an important role in regulating the nuclear translocation of the receptor. We review the evidence for the role of AIP in protein translocation and compare the potential functions of AIPL1 in the translocation of its interacting partner the NEDD8 ultimate buster protein 1.

  7. NMR assignments of the FKBP-type PPIase domain of the human aryl-hydrocarbon receptor-interacting protein (AIP).

    PubMed

    Linnert, Miriam; Haupt, Katja; Lin, Yi-Jan; Kissing, Sandra; Paschke, Anne-Katrin; Fischer, Gunter; Weiwad, Matthias; Lücke, Christian

    2012-10-01

    The aryl-hydrocarbon receptor-interacting protein (AIP) interacts with several protein binding partners and has been associated with pituitary tumor development. Here, we report nearly complete (1)H, (13)C and (15)N chemical shift assignments for the N-terminal AIP(2-166) segment, which has been predicted to represent a FKBP-type PPIase domain. Sequence alignment with the prototypic FKBP12, however, reveals disagreements between the AIP chemical shift index consensus and the corresponding FKBP12 secondary structure elements.

  8. AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience.

    PubMed

    Ramírez-Rentería, Claudia; Hernández-Ramírez, Laura C; Portocarrero-Ortiz, Lesly; Vargas, Guadalupe; Melgar, Virgilio; Espinosa, Etual; Espinosa-de-Los-Monteros, Ana Laura; Sosa, Ernesto; González, Baldomero; Zúñiga, Sergio; Unterländer, Martina; Burger, Joachim; Stals, Karen; Bussell, Anne-Marie; Ellard, Sian; Dang, Mary; Iacovazzo, Donato; Kapur, Sonal; Gabrovska, Plamena; Radian, Serban; Roncaroli, Federico; Korbonits, Márta; Mercado, Moisés

    2016-08-01

    Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic acromegaly, their prevalence among young patients is nonnegligible. The objectives of this study were to evaluate the frequency of AIP mutations in a cohort of Mexican patients with acromegaly with disease onset before the age of 30 and to search for molecular abnormalities in the AIP gene in teeth obtained from the "Tampico Giant". Peripheral blood DNA from 71 patients with acromegaly (51 females) with disease onset <30 years was analysed (median age of disease onset of 23 years) and correlated with clinical, biochemical and imaging characteristics. Sequencing was also carried out in DNA extracted from teeth of the Tampico Giant. Five patients (7 %) harboured heterozygous, germline mutations of the AIP gene. In two of them (a 9-year-old girl with gigantism and a young man with symptoms of GH excess since age 14) the c.910C>T (p.Arg304Ter), well-known truncating mutation was identified; in one of these two cases and her identical twin sister, the mutation proved to be a de novo event, since neither of their parents were found to be carriers. In the remaining three patients, new mutations were identified: a frameshift mutation (c.976_977insC, p.Gly326AfsTer), an in-frame deletion (c.872_877del, p.Val291_Leu292del) and a nonsense mutation (c.868A > T, p.Lys290Ter), which are predicted to be pathogenic based on in silico analysis. Patients with AIP mutations tended to have an earlier onset of acromegaly and harboured larger and more invasive tumours. A previously described genetic variant of unknown significance (c.869C > T, p.Ala299Val) was identified in DNA from the Tampico Giant. The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts. Our results support the need for genetic evaluation of patients with early onset acromegaly.

  9. Acromegaly Is More Severe in Patients With AHR or AIP Gene Variants Living in Highly Polluted Areas.

    PubMed

    Cannavo, S; Ragonese, M; Puglisi, S; Romeo, P D; Torre, M L; Alibrandi, A; Scaroni, C; Occhi, G; Ceccato, F; Regazzo, D; De Menis, E; Sartorato, P; Arnaldi, G; Trementino, L; Trimarchi, F; Ferrau, F

    2016-04-01

    In this multicentric study, we aimed to correlate the occurrence of AHR and/or AIP. genes variants in acromegalic patients with the disease severity and/or with the response to somatostatin analogs (SSa) treatment, according to pollution exposition.

  10. AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma.

    PubMed

    Nishizawa, H; Fukuoka, H; Iguchi, G; Inoshita, N; Yamada, S; Takahashi, Y

    2013-05-01

    Pituitary adenoma with neuronal choristoma (PANCH) is a rare condition that includes ganglion cells and GH-producing tumor that is characterized by sparsely granulated somatotroph cell type. However, the pathophysiology of this condition remains to be elucidated. We report a case of 46-year-old woman with acromegaly caused by PANCH. The patient had a large and invasive macroadenoma that was resistant to preoperative therapy with somatostatin analogue (SSA) and dopamine agonist. Histological examination showed typical diffuse, chromophobe-type adenoma containing ganglion cells, and sparsely granulated somatotroph cell type, which were consistent with PANCH. Genetic analysis showed heterozygous germline missense mutation in the AIP gene that results in Y261X amino acid substitution. The clinical characteristics of acromegaly associated with AIP mutations are reportedly macroadenomas with tumor extension and invasion, lower decreases in GH and IGF-I and less tumor shrinkage with SSA treatment, and sparsely granulated somatotroph cell type, which are comparable with those observed in PANCH. Taken together, the mutation in AIP gene may explain the clinical characteristics and pathogenesis of PANCH.

  11. Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.

    PubMed

    Raitila, Anniina; Lehtonen, Heli J; Arola, Johanna; Heliövaara, Elina; Ahlsten, Manuel; Georgitsi, Marianthi; Jalanko, Anu; Paetau, Anders; Aaltonen, Lauri A; Karhu, Auli

    2010-10-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigenesis, we generated an Aip mouse model. Heterozygous mice developed normally but were prone to pituitary adenomas, in particular to those secreting GH. A complete loss of AIP was detected in these lesions, and full penetrance was reached at the age of 15 months. No excess of any other tumor type was found. Ki-67 analysis indicated that Aip-deficient tumors have higher proliferation rates compared with Aip-proficient tumors, suggesting a more aggressive disease. Similar to human AIP-deficient pituitary adenomas, immunohistochemical studies showed that expression of aryl hydrocarbon receptor nuclear translocator 1 or 2 (ARNT or ARNT2) protein was lost in the mouse tumors, suggesting that mechanisms of AIP-related tumorigenesis involve aberrant ARNT function. The Aip(+/-) mouse appears to be an excellent model for the respective human disease phenotype. This model constitutes a tool to further study AIP-associated pituitary tumorigenesis and may be potentially valuable in efforts to develop therapeutic strategies to treat pituitary adenomas.

  12. Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

    PubMed Central

    Hernández-Ramírez, Laura C.; Martucci, Federico; Morgan, Rhodri M. L.; Trivellin, Giampaolo; Tilley, Daniel; Ramos-Guajardo, Nancy; Iacovazzo, Donato; D'Acquisto, Fulvio; Prodromou, Chrisostomos

    2016-01-01

    Context: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood. We have identified the primary mechanism of loss of function for missense AIPmuts. Objective: This study sought to analyze the mechanism/speed of protein turnover of wild-type and missense AIP variants, correlating protein half-life with clinical parameters. Design and Setting: Half-life and protein–protein interaction experiments and cross-sectional analysis of AIPmut positive patients' data were performed in a clinical academic research institution. Patients: Data were obtained from our cohort of pituitary adenoma patients and literature-reported cases. Interventions: Protein turnover of endogenous AIP in two cell lines and fifteen AIP variants overexpressed in HEK293 cells was analyzed via cycloheximide chase and proteasome inhibition. Glutathione-S-transferase pull-down and quantitative mass spectrometry identified proteins involved in AIP degradation; results were confirmed by coimmunoprecipitation and gene knockdown. Relevant clinical data was collected. Main Outcome Measures: Half-life of wild-type and mutant AIP proteins and its correlation with clinical parameters. Results: Endogenous AIP half-life was similar in HEK293 and lymphoblastoid cells (43.5 and 32.7 h). AIP variants were divided into stable proteins (median, 77.7 h; interquartile range [IQR], 60.7–92.9 h), and those with short (median, 27 h; IQR, 21.6–28.7 h) or very short (median, 7.7 h; IQR, 5.6–10.5 h) half-life; proteasomal inhibition rescued the rapid degradation of mutant proteins. The experimental half-life significantly correlated with age at diagnosis of acromegaly/gigantism (r = 0.411; P = .002). The FBXO3-containing SKP1–CUL1–F-box protein complex was identified as the E3 ubiquitin-ligase recognizing AIP. Conclusions: AIP is a stable protein, driven to ubiquitination by the SKP1–CUL1–F-box protein complex

  13. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.

    PubMed

    Morgan, Rhodri M L; Hernández-Ramírez, Laura C; Trivellin, Giampaolo; Zhou, Lihong; Roe, S Mark; Korbonits, Márta; Prodromou, Chrisostomos

    2012-01-01

    Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain of AIP at high resolution, which has allowed a detailed analysis of how disease-associated mutations impact on the structural integrity of the TPR domain. A subset of C-terminal α-7 helix (Cα-7h) mutations, R304* (nonsense mutation), R304Q, Q307* and R325Q, a known site for AhR and PDE4A5 client-protein interaction, occur beyond those that interact with the conserved MEEVD and EDDVE sequences of HSP90 and TOMM20. These C-terminal AIP mutations appear to only disrupt client-protein binding to the Cα-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved HSP90 motif, MEEVD, and the equivalent sequence (EDDVE) of TOMM20.

  14. Spatial Representations in Local Field Potential Activity of Primate Anterior Intraparietal Cortex (AIP).

    PubMed

    Lehmann, Sebastian J; Scherberger, Hansjörg

    2015-01-01

    The execution of reach-to-grasp movements in order to interact with our environment is an important subset of the human movement repertoire. To coordinate such goal-directed movements, information about the relative spatial position of target and effector (in this case the hand) has to be continuously integrated and processed. Recently, we reported the existence of spatial representations in spiking-activity of the cortical fronto-parietal grasp network (Lehmann & Scherberger 2013), and in particular in the anterior intraparietal cortex (AIP). To further investigate the nature of these spatial representations, we explored in two rhesus monkeys (Macaca mulatta) how different frequency bands of the local field potential (LFP) in AIP are modulated by grip type, target position, and gaze position, during the planning and execution of reach-to-grasp movements. We systematically varied grasp type, spatial target, and gaze position and found that both spatial and grasp information were encoded in a variety of frequency bands (1-13Hz, 13-30Hz, 30-60Hz, and 60-100Hz, respectively). Whereas the representation of grasp type strongly increased towards and during movement execution, spatial information was represented throughout the task. Both spatial and grasp type representations could be readily decoded from all frequency bands. The fact that grasp type and spatial (reach) information was found not only in spiking activity, but also in various LFP frequency bands of AIP, might significantly contribute to the development of LFP-based neural interfaces for the control of upper limb prostheses.

  15. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers

    PubMed Central

    Hernández-Ramírez, Laura C.; Gabrovska, Plamena; Dénes, Judit; Stals, Karen; Trivellin, Giampaolo; Tilley, Daniel; Ferraù, Francesco; Evanson, Jane; Ellard, Sian; Grossman, Ashley B.; Roncaroli, Federico; Gadelha, Mônica R.

    2015-01-01

    Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease. Objective: To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members. Design: This was an observational, longitudinal study conducted over 7 years. Setting: International collaborative study conducted at referral centers for pituitary diseases. Participants: FIPA families (n = 216) and sporadic young-onset (≤30 y) pituitary adenoma patients (n = 404) participated in the study. Interventions: We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant. Main Outcome Measure(s): We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis. Results: Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals. A total of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening. Conclusions: A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas. PMID

  16. A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred.

    PubMed

    Cansu, Güven Barış; Taşkıran, Bengür; Trivellin, Giampaolo; Faucz, Fabio R; Stratakis, Constantine A

    2016-07-01

    Familial isolated pituitary adenomas (FIPA) constitute 2-3% of pituitary tumours. AIP is the most commonly mutated gene in FIPA. We herein report a novel germline mutation of the AIP gene in a family with FIPA. We present two patients, a father and his 12-year-old daughter, diagnosed clinically and using laboratory measures with acromegaly-gigantism. Both underwent transsphenoidal hypophyseal surgery for macroadenomas. We initially detected a novel heterozygous germline AIP mutation, c.836G>A (p.W279*), in the father's DNA. We then found the same mutation in his affected daughter. Pituitary adenomas associated with AIP mutations mostly present as FIPA (68%) at an early age (78% occur at <30 years old). They are often growth hormone (GH) - or prolactin - secreting macroadenomas (88%) that have already extended beyond the sella at the time of diagnosis. Acromegalic cases are resistant to somatostatin analogues and multimodal management is frequently essential to control the disease. Our patients had normalized GH/IGF-1 values soon after surgery, although enough time may not have elapsed to reach final cure. While penetrance of the disease can be as low as 10% in FIPA, especially children and young patients with somatotropinoma and prolactinoma should be surveyed for inactivating mutations or deletions in AIP. Determining the causative mutations may be of assistance in early diagnosis, treatment success, and genetic counseling.

  17. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures (Invited)

    NASA Astrophysics Data System (ADS)

    Nativi, S.; Santoro, M.

    2009-12-01

    Currently, one of the major challenges for scientific community is the study of climate change effects on life on Earth. To achieve this, it is crucial to understand how climate change will impact on biodiversity and, in this context, several application scenarios require modeling the impact of climate change on distribution of individual species. In the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2), the Climate Change & Biodiversity thematic Working Group developed three significant user scenarios. A couple of them make use of a GEOSS-based framework to study the impact of climate change factors on regional species distribution. The presentation introduces and discusses this framework which provides an interoperability infrastructures to loosely couple standard services and components to discover and access climate and biodiversity data, and run forecast and processing models. The framework is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components publish climate, environmental and biodiversity datasets; e)Ecological Niche Model Server: this component is able to run one or more Ecological Niche Models (ENM) on selected biodiversity and climate datasets; f)Data Access

  18. GEOSS AIP-2 Climate Change and Biodiversity Use Scenarios: Interoperability Infrastructures

    NASA Astrophysics Data System (ADS)

    Nativi, Stefano; Santoro, Mattia

    2010-05-01

    In the last years, scientific community is producing great efforts in order to study the effects of climate change on life on Earth. In this general framework, a key role is played by the impact of climate change on biodiversity. To assess this, several use scenarios require the modeling of climatological change impact on the regional distribution of biodiversity species. Designing and developing interoperability infrastructures which enable scientists to search, discover, access and use multi-disciplinary resources (i.e. datasets, services, models, etc.) is currently one of the main research fields for the Earth and Space Science Informatics. This presentation introduces and discusses an interoperability infrastructure which implements the discovery, access, and chaining of loosely-coupled resources in the climatology and biodiversity domains. This allows to set up and run forecast and processing models. The presented framework was successfully developed and experimented in the context of GEOSS AIP-2 (Global Earth Observation System of Systems, Architecture Implementation Pilot- Phase 2) Climate Change & Biodiversity thematic Working Group. This interoperability infrastructure is comprised of the following main components and services: a)GEO Portal: through this component end user is able to search, find and access the needed services for the scenario execution; b)Graphical User Interface (GUI): this component provides user interaction functionalities. It controls the workflow manager to perform the required operations for the scenario implementation; c)Use Scenario controller: this component acts as a workflow controller implementing the scenario business process -i.e. a typical climate change & biodiversity projection scenario; d)Service Broker implementing Mediation Services: this component realizes a distributed catalogue which federates several discovery and access components (exposing them through a unique CSW standard interface). Federated components

  19. ConfChem Conference on Flipped Classroom: Reclaiming Face Time--How an Organic Chemistry Flipped Classroom Provided Access to Increased Guided Engagement

    ERIC Educational Resources Information Center

    Trogden, Bridget G.

    2015-01-01

    Students' active engagement is one of the most critical challenges to any successful learning environment. The blending of active engagement along with rich, meaningful content is necessary for chemical educators to re-examine the purpose of the chemistry classroom. The Spring 2014 ConfChem conference, Flipped Classroom, was held from May 9 to…

  20. Internal Energy Transfer and Dissociation Model Development using Accelerated First-Principles Simulations of Hypersonic Flow Features

    DTIC Science & Technology

    2013-07-11

    for nitrogen using molecular dynamics simulation”, 28th International Symposium on Rarefied Gas Dynamics, AIP Conf. Proc. 1501, 519-526 (2012); doi...accurate for highly nonequilibrium flows relevant to rarefied flows and sharp flow features with small length scales. Currently, both CFD and DSMC use...While such simulations are not expected to overlap with the 3D near-continuum flows in the near future, they certainly overlap with rarefied DSMC

  1. Internal Energy Transfer and Dissociation Model Development using Accelerated First-Principles Simulations of Hypersonic Flow Features

    DTIC Science & Technology

    2013-07-09

    rarefied   gas   flow   simulations  by  the  DSMC  method,”  Phys.  Fluids...Symposium on Rarefied Gas Dynamics, AIP Conf. Proc. 1501, 519-526 (2012); doi: 10.1063/1.4769583 Valentini, P., Zhang, C., and Schwartzentruber, T.E...method [1], which simulates the Boltzmann equation [2] and is therefore accurate for highly nonequilibrium flows relevant to rarefied flows and

  2. Thermal Mechanical Fatigue Cracks Growth from Laser Drilled Holes in Single Crystal Material (Preprint)

    DTIC Science & Technology

    2012-03-01

    analysis of that data.; (iii) fast cycle thermomechanical fatigue testing using active cooling allowing 30 second heat up and 30 second cooling under...Genest M., Dudzinski D. C., Bulmer S., and Kersey R., Crack Detection Using Induction Thermography for Thermomechanical Fatigue Test AIP Conf. Proc. June...results undergoing thermomechanical fatigue showed that the life of TMF specimens with notched laser drilled holes exhibit a debit by as much as 4

  3. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.

    PubMed

    Katayama, Hiroshi; Sasai, Kaori; Czerniak, Bogdan A; Carter, Jennifer L; Sen, Subrata

    2007-12-01

    Aurora-A is an oncogenic kinase that plays essential roles in mitosis as well as cell survival. Aurora-A interacting protein (AIP) was identified as a negative regulator of Aurora-A with its ectopic over expression inducing destabilization of Aurora-A protein. Here we present evidence that in human cells, contrary to the earlier report, AIP functions in stabilizing rather than destabilizing Aurora-A. Furthermore, AIP is phosphorylated on Serine 70 by Aurora-A but not Aurora-B and expression of phosphorylation mimic mutant of AIP results in prolonged protein stability compared to unphosphorylatable mutant. We observed that when co-expressed with AIP, protein levels of both Aurora-A and Aurora-B are markedly elevated regardless of their kinase activities and phosphorylation state of AIP. Interaction of Aurora kinases with AIP is necessary for this elevated stability. This phenomenon is commonly detected in several human cancer cell lines used in this study. Depletion of AIP by RNA interference decreased Aurora-A but not Aurora-B in two of the three cell lines analyzed, indicating that under physiological condition, AIP functions in stabilization of Aurora-A but not Aurora-B, though this regulation may be dependent on additional factors as well. Further, AIP siRNA induced cell cycle arrest at G2/M, which is consistent with anticipated loss of function of Aurora-A in these cells. Thus, our study provides the first evidence of a role for AIP in G2/M cell cycle progression by cooperatively regulating protein stabilization of its up-stream regulator, Aurora-A kinase through protein-protein interaction as well as protein phosphorylation.

  4. Web Services for Astronomical Databases: Connecting AIPS++ to the Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Douthit, M. C.

    2002-12-01

    In the year 2010, the NRAO will be operating four of the world's most powerful radio telescopes: GBT, EVLA, VLBA, and ALMA (with international partnership). Multi-Terabyte data sets will quickly accumulate with a rate of twenty-five to fifty Megabytes of data per second generated by ALMA and EVLA each. It will be imperative for scientists to possess software capable of automated data reduction, image synthesis, and archiving. With the evolution of AIPS++ and the recently developed concepts of the image pipeline, the participation of the NRAO in the virtual observatories of the future is now on the horizon giving birth to the need for fast archive access and web service development in AIPS++. When the software package began over 10 years ago, it was not designed for data transfer via the web. In response to the demands of the NVO, we have designed and implemented an application layer that will allow our system to communicate with others. Sponsored by the NRAO and California State University, San Marcos.

  5. Triangles have goals too: understanding action representation in left aIPS.

    PubMed

    Ramsey, Richard; Hamilton, Antonia F de C

    2010-07-01

    Humans freely interpret moving shapes as being "alive" and having social intentions, such as beliefs and desires. The brain systems underpinning these processes are the same as those used to detect animacy and infer mental states from human behaviour. However, it is not yet known if the brain systems that respond to human action-goals also respond to the action-goals of shapes. In the present paper, we used a repetition suppression paradigm during functional magnetic resonance imaging (fMRI) to examine brain systems that respond to the action-goals of shapes. Participants watched video clips of simple, geometrical shapes performing different 'take-object' goals. Repeated presentation of the same goal suppressed the blood oxygen level-dependent (BOLD) response in left anterior intraparietal sulcus (aIPS), a brain region known to distinguish the goals of human hand actions. This finding shows that left aIPS shows similar sensitivity to the action-goals of human and non-human agents. Our data complement previous work on animacy perception and mental state inference, which suggest components of the social brain are driven by the type of action comprehension that is engaged rather than by the form of the acting agent (i.e., human or shape). Further, the results have consequence for theories of goal understanding in situations without access to biological form or motion.

  6. A case of focal autoimmune pancreatitis (AIP) mimicking an intraductal papillary mucinous neoplasm (IPMN).

    PubMed

    Nakaji, So; Hirata, Nobuto; Fujii, Hiroyuki; Iwaki, Kosuke; Shiratori, Toshiyasu; Kobayashi, Masayoshi; Wakasugi, Satoshi; Ishii, Eiji; Takeyama, Hiroyuki; Hoshi, Kazuei

    2013-08-01

    The present case involved a 76-year-old man with a cystic mass in the head of his pancreas. The cystic lesion, which measured 17.7 × 9.8 mm, was first detected by ultrasonography (US) at the age of 72 years. Follow-up endoscopic ultrasonography (EUS) performed at 4 years after the lesion had first been detected revealed a mural nodule measuring 14.0 × 8.4 mm in the cyst. Endoscopic retrograde pancreatography (ERP) imaging revealed that the main pancreatic duct was in communication with the cyst and that there was no irregular narrowing of the main pancreatic duct. On the basis of these results, the patient was diagnosed with an intraductal papillary mucinous neoplasm (IPMN), and stomach-preserving pancreaticoduodenectomy was performed. A histopathological examination revealed that the interior of the cystic part of the lesion was lined by a pancreatic ductal epithelium. A pathological examination of the nodular lesion detected storiform fibrosis, severe lymphoplasmacytic infiltration, and hyperplasia in the pancreatic duct epithelium together with a small amount of mucus. On immunohistological staining, the infiltrating lymphoplasmacytes were found to be positive for IgG4. Accordingly, the patient was diagnosed with focal autoimmune pancreatitis (AIP). In conclusion, we reported a case of focal AIP mimicking IPMN. This case showed neither enlargement of the pancreas nor irregular narrowing of the main pancreatic duct.

  7. Advanced Information Processing System (AIPS)-based fault tolerant avionics architecture for launch vehicles

    NASA Technical Reports Server (NTRS)

    Lala, Jaynarayan H.; Harper, Richard E.; Jaskowiak, Kenneth R.; Rosch, Gene; Alger, Linda S.; Schor, Andrei L.

    1990-01-01

    An avionics architecture for the advanced launch system (ALS) that uses validated hardware and software building blocks developed under the advanced information processing system program is presented. The AIPS for ALS architecture defined is preliminary, and reliability requirements can be met by the AIPS hardware and software building blocks that are built using the state-of-the-art technology available in the 1992-93 time frame. The level of detail in the architecture definition reflects the level of detail available in the ALS requirements. As the avionics requirements are refined, the architecture can also be refined and defined in greater detail with the help of analysis and simulation tools. A useful methodology is demonstrated for investigating the impact of the avionics suite to the recurring cost of the ALS. It is shown that allowing the vehicle to launch with selected detected failures can potentially reduce the recurring launch costs. A comparative analysis shows that validated fault-tolerant avionics built out of Class B parts can result in lower life-cycle-cost in comparison to simplex avionics built out of Class S parts or other redundant architectures.

  8. EuroGEOSS/GENESIS ``e-Habitat'' AIP-3 Use Scenario

    NASA Astrophysics Data System (ADS)

    Mazzetti, P.; Dubois, G.; Santoro, M.; Peedell, S.; de Longueville, B.; Nativi, S.; Craglia, M.

    2010-12-01

    Natural ecosystems are in rapid decline. Major habitats are disappearing at a speed never observed before. The current rate of species extinction is several orders of magnitude higher than the background rate from the fossil record. Protected Areas (PAs) and Protected Area Systems are designed to conserve natural and cultural resources, to maintain biodiversity (ecosystems, species, genes) and ecosystem services. The scientific challenge of understanding how environmental and climatological factors impact on ecosystems and habitats requires the use of information from different scientific domains. Thus, multidisciplinary interoperability is a crucial requirement for a framework aiming to support scientists. The Group on Earth Observations (or GEO) is coordinating international efforts to build a Global Earth Observation System of Systems (GEOSS). This emerging public infrastructure is interconnecting a diverse and growing array of instruments and systems for monitoring and forecasting changes in the global environment. This “system of systems” supports multidisciplinary and cross-disciplinary scientific researches. The presented GEOSS-based interoperability framework facilitates the discovery and exploitation of datasets and models from heterogeneous scientific domains and Information Technology services (data sources). The GEO Architecture and Data Committee (ADC) launched the Architecture Implementation Pilot (AIP) Initiative to develop and deploy new processes and infrastructure components for the GEOSS Common Infrastructure (GCI) and the broader GEOSS architecture. The current AIP Phase 3 (AIP-3) aims to increase GEOSS capacity to support several strategic Societal Benefit Areas (SBAs) including: Disaster Management, Health/Air Quality, Biodiversity, Energy, Health/Disease and Water. As to Biodiversity, the EC-funded EuroGEOSS (http://www.eurogeoss.eu) and GENESIS (http://www.genesis-fp7.eu) projects have developed a use scenario called

  9. Familial isolated pituitary adenoma caused by a Aip gene mutation not described before in a family context.

    PubMed

    García-Arnés, J A; González-Molero, I; Oriola, J; Mazuecos, N; Luque, R; Castaño, J; Arraez, M A

    2013-12-01

    The cause of familial isolated pituitary adenomas (FIPA) remains unknown in a high percentage of cases, but the AIP gene plays an important role in the etiology. The aim of the study is to describe a family with FIPA syndrome and the results of genomic studies. A 16-year-old man had a giant prolactinoma resistant tomedical treatment with delayed growth and pubertal development. His mother had been previously diagnosed with a nonfunctioning pituitary macroadenoma. Transsphenoidal endoscopic resection was performed and a genetic study revealed a heterozygous mutation in exon 6: 974G>A (p.Arg325Gln). Because the AIP gene is a tumor suppressor gene, we searched for loss of heterozygosity within the AIP gene by amplifying exon 6 from tumor tissue of the patient. In the electropherogram, only the A allele was amplified (hemizygous state), indicating loss of the normal allele. We report a Spanish family with FIPA in whom a mutation in the AIP gene previously unreported in a familiar context was identified.

  10. Aggressive prolactinoma in a child related to germline mutation in the ARYL hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Naves, Luciana Ansaneli; Jaffrain-Rea, Marie-Lise; Vêncio, Sergio Alberto Cunha; Jacomini, Clausmir Zaneti; Casulari, Luiz Augusto; Daly, Adrian F; Beckers, Albert

    2010-11-01

    The objective of this study was to describe a familial screening for AIP mutations in the context of aggressive prolactinoma in childhood. A 12-year-old boy, presented headaches and bilateral hemianopsia. He had adequate height and weight for his age (50(th) percentile), Tanner stage G1 P1. His bone age was 10 years. Prolactin was 10.560 ng/mL (3-25), FSH and LH were undetectable, IGF-1, TSH, Free T4, ACTH, and cortisol were within normal ranges. MRI showed a pituitary macroadenoma, 5.3 X 4.0 X 3.5 cm with compression of the optic chiasm, bilateral cavernous sinus invasion, encasement of carotids, and extension to clivus. Surgical debulking was performed. Resistance to cabergoline was characterized and he was submitted to two surgeries and radiotherapy. Immunohistochemical evaluation included prolactin, ACTH, GH, FSH, LH,AIP, c-erb B2, Ki-67, and p53. Genomic DNA was isolated from the index case and 48 relatives, PCR and sequencing were performed.A germline A195V mutation in AIP was identified in the index case and in five asymptomatic relatives. Germline mutations in the AIP gene may be involved in the predisposition to pituitary adenoma formation, as cause or co-factor in pathogenesis of aggressive tumors in young patients.

  11. Representation of continuous hand and arm movements in macaque areas M1, F5, and AIP: a comparative decoding study

    NASA Astrophysics Data System (ADS)

    Menz, Veera Katharina; Schaffelhofer, Stefan; Scherberger, Hansjörg

    2015-10-01

    Objective. In the last decade, multiple brain areas have been investigated with respect to their decoding capability of continuous arm or hand movements. So far, these studies have mainly focused on motor or premotor areas like M1 and F5. However, there is accumulating evidence that anterior intraparietal area (AIP) in the parietal cortex also contains information about continuous movement. Approach. In this study, we decoded 27 degrees of freedom representing complete hand and arm kinematics during a delayed grasping task from simultaneously recorded activity in areas M1, F5, and AIP of two macaque monkeys (Macaca mulatta). Main results. We found that all three areas provided decoding performances that lay significantly above chance. In particular, M1 yielded highest decoding accuracy followed by F5 and AIP. Furthermore, we provide support for the notion that AIP does not only code categorical visual features of objects to be grasped, but also contains a substantial amount of temporal kinematic information. Significance. This fact could be utilized in future developments of neural interfaces restoring hand and arm movements.

  12. Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.

    PubMed

    Radian, Serban; Diekmann, Yoan; Gabrovska, Plamena; Holland, Brendan; Bradley, Lisa; Wallace, Helen; Stals, Karen; Bussell, Anna-Marie; McGurren, Karen; Cuesta, Martin; Ryan, Anthony W; Herincs, Maria; Hernández-Ramírez, Laura C; Holland, Aidan; Samuels, Jade; Aflorei, Elena Daniela; Barry, Sayka; Dénes, Judit; Pernicova, Ida; Stiles, Craig E; Trivellin, Giampaolo; McCloskey, Ronan; Ajzensztejn, Michal; Abid, Noina; Akker, Scott A; Mercado, Moises; Cohen, Mark; Thakker, Rajesh V; Baldeweg, Stephanie; Barkan, Ariel; Musat, Madalina; Levy, Miles; Orme, Stephen M; Unterländer, Martina; Burger, Joachim; Kumar, Ajith V; Ellard, Sian; McPartlin, Joseph; McManus, Ross; Linden, Gerard J; Atkinson, Brew; Balding, David J; Agha, Amar; Thompson, Chris J; Hunter, Steven J; Thomas, Mark G; Morrison, Patrick J; Korbonits, Márta

    2017-01-01

    The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) (or p.R304(*) ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304(*) carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011-0.0047) and zero in ROI (0-0.0014). R304(*) prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P < 0.05), but not in ROI (2/29, 6.8%) versus non-Irish patients (0-2.41%). Haploblock conservation supported a common ancestor for all the 18 identified Irish pedigrees (81 carriers, 30 affected). Time to most recent common ancestor (tMRCA) was 2550 (1,275-5,000) years. tMRCA-based simulations predicted 432 (90-5,175) current carriers, including 86 affected (18-1,035) for 20% penetrance. In conclusion, R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP-related disease.

  13. Erwinia amylovora affects the phenylpropanoid-flavonoid pathway in mature leaves of Pyrus communis cv. Conférence.

    PubMed

    Vrancken, K; Holtappels, M; Schoofs, H; Deckers, T; Treutter, D; Valcke, R

    2013-11-01

    Flavonoids, which are synthesized by the phenylpropanoid-flavonoid pathway, not only contribute to fruit colour and photoprotection, they also may provide antimicrobial and structural components during interaction with micro-organisms. A possible response of this pathway was assessed in both mature and immature leaves of shoots of 2-year-old pear trees cv. Conférence, which were inoculated with the gram-negative bacterium Erwinia amylovora strain SGB 225/12, were mock-inoculated or were left untreated. The phenylpropanoid-flavonoid pathway was analysed by histological studies, by gene expression using RT-qPCR and by HPLC analyses of the metabolites at different time intervals after infection. Transcription patterns of two key genes anthocyanidin reductase (ANR) and chalcone synthase (CHS) related to the phenylpropanoid-flavonoid pathway showed differences between control, mock-inoculated and E. amylovora-inoculated mature leaves, with the strongest reaction 48 h after inoculation. The impact of E. amylovora was also visualised in histological sections, and confirmed by HPLC, as epicatechin -which is produced via ANR- augmented 72 h after inoculation in infected leaf tissue. Besides the effect of treatments, ontogenesis-related differences were found as well. The increase of certain key genes, the rise in epicatechin and the visualisation in several histological sections in this study suggest a non-negligible impact on the phenylpropanoid-flavonoid pathway in Pyrus communis due to inoculation with E. amylovora. In this study, we propose a potential role of this pathway in defence mechanisms, providing a detailed analysis of the response of this system attributable to inoculation with E. amylovora.

  14. Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

    PubMed

    Beckers, Albert; Aaltonen, Lauri A; Daly, Adrian F; Karhu, Auli

    2013-04-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  15. Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene

    PubMed Central

    Aaltonen, Lauri A.; Daly, Adrian F.

    2013-01-01

    Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple endocrine neoplasia type 1 and Carney complex. FIPA families comprise approximately 2% of pituitary adenomas and represent a clinical entity with homogeneous or heterogeneous pituitary adenoma types occurring within the same kindred. The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families. Germline AIP mutations have been shown to associate with the occurrence of large pituitary adenomas that occur at a young age, predominantly in children/adolescents and young adults. AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. Gigantism is a particular feature of AIP mutations and occurs in more than one third of affected somatotropinoma patients. Study of pituitary adenoma patients with AIP mutations has demonstrated that these cases raise clinical challenges to successful treatment. Extensive research on the biology of AIP and new advances in mouse Aip knockout models demonstrate multiple pathways by which AIP may contribute to tumorigenesis. This review assesses

  16. Aryl Hydrocarbon Receptor-Interacting Protein (AIP) N-Terminus Gene Mutations Identified in Pituitary Adenoma Patients Alter Protein Stability and Function.

    PubMed

    Formosa, Robert; Vassallo, Josanne

    2017-03-02

    Mutations spanning the entire aryl hydrocarbon receptor-interacting protein (AIP) gene have been found in isolated familial cases of pituitary adenomas (PA). Missense mutations located in the N-terminus of the gene have been identified in several patients. However, the functional significance of these mutations remains a matter of controversy. In most studies, the N-terminus of AIP has been shown to regulate protein stability and subcellular localization of the AIP-AHR-HSP90 complex but not to be involved in protein-protein interactions. Other studies found that the N-terminal domain interacts directly with other proteins. The aim of this study was to analyze whether specific N-terminus AIP mutations identified in PA patients would be functionally different from wild-type (WT) AIP. In vitro analyses were used to assess the role of known N-terminus variants, a locally identified mutant, R9Q, and three other commonly genotyped N-terminus mutations R16H, V49M and K103R are found in PA patients. Given the functional effect of WT AIP on cAMP signalling alterations caused by N-terminus mutants on this pathway were also analyzed in GH3 cells. Results indicate that N-terminus mutations lead to de-regulation of the effect of WT AIP on cAMP signalling and increased cAMP thresholds in GH3 cells resulting in increased growth hormone (GH) secretion. Cycloheximide chase analysis identified a variation in protein degradation patterns between WT and N-terminus variants. Therefore, both functional and structural studies reveal that N-terminus mutations in the AIP gene alter protein behaviour significantly and hence can truly be pathogenic in nature.

  17. Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.

    PubMed Central

    Amberg, D C; Zahner, J E; Mulholland, J W; Pringle, J R; Botstein, D

    1997-01-01

    A search for Saccharomyces cerevisiae proteins that interact with actin in the two-hybrid system and a screen for mutants that affect the bipolar budding pattern identified the same gene, AIP3/BUD6. This gene is not essential for mitotic growth but is necessary for normal morphogenesis. MATa/alpha daughter cells lacking Aip3p place their first buds normally at their distal poles but choose random sites for budding in subsequent cell cycles. This suggests that actin and associated proteins are involved in placing the bipolar positional marker at the division site but not at the distal tip of the daughter cell. In addition, although aip3 mutant cells are not obviously defective in the initial polarization of the cytoskeleton at the time of bud emergence, they appear to lose cytoskeletal polarity as the bud enlarges, resulting in the formation of cells that are larger and rounder than normal. aip3 mutant cells also show inefficient nuclear migration and nuclear division, defects in the organization of the secretory system, and abnormal septation, all defects that presumably reflect the involvement of Aip3p in the organization and/or function of the actin cytoskeleton. The sequence of Aip3p is novel but contains a predicted coiled-coil domain near its C terminus that may mediate the observed homo-oligomerization of the protein. Aip3p shows a distinctive localization pattern that correlates well with its likely sites of action: it appears at the presumptive bud site prior to bud emergence, remains near the tips of small bund, and forms a ring (or pair of rings) in the mother-bud neck that is detectable early in the cell cycle but becomes more prominent prior to cytokinesis. Surprisingly, the localization of Aip3p does not appear to require either polarized actin or the septin proteins of the neck filaments. Images PMID:9247651

  18. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.

    PubMed

    Panner, Amith; Crane, Courtney A; Weng, Changjiang; Feletti, Alberto; Fang, Shanna; Parsa, Andrew T; Pieper, Russell O

    2010-06-15

    The antiapoptotic protein FLIP(S) is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homologue (PTEN)-Akt-atrophin-interacting protein 4 (AIP4) pathway regulates FLIP(S) ubiquitination and stability, although the means by which PTEN and Akt were linked to AIP4 activity were unclear. Here, we report that a second regulator of ubiquitin metabolism, the ubiquitin-specific protease 8 (USP8), is a downstream target of Akt, and that USP8 links Akt to AIP4 and the regulation of FLIP(S) stability and TRAIL resistance. In human GBM xenografts, levels of USP8 correlated inversely with pAkt levels, and genetic or pharmacologic manipulation of Akt regulated USP8 levels in an inverse manner. Overexpression of wild-type USP8, but not catalytically inactive USP8, increased FLIP(S) ubiquitination, decreased FLIP(S) half-life, decreased FLIP(S) steady-state levels, and decreased TRAIL resistance, whereas short interfering RNA (siRNA)-mediated suppression of USP8 levels had the opposite effect. Because high levels of the USP8 deubiquitinase correlated with high levels of FLIP(S) ubiquitination, USP8 seemed to control FLIP(S) ubiquitination through an intermediate target. Consistent with this idea, overexpression of wild-type USP8 decreased the ubiquitination of the FLIP(S) E3 ubiquitin ligase AIP4, an event previously shown to increase AIP4-FLIP(S) interaction, whereas siRNA-mediated suppression of USP8 increased AIP4 ubiquitination. Furthermore, the suppression of FLIP(S) levels by USP8 overexpression was reversed by the introduction of siRNA targeting AIP4. These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIP(S) stability and TRAIL sensitivity.

  19. USP8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

    PubMed Central

    Panner, Amith; Crane, Courtney A.; Weng, Changjiang; Feletti, Alberto; Fang, Shanna; Parsa, Andrew T.; Pieper, Russell O.

    2010-01-01

    The anti-apoptotic protein FLIPS is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homolog (PTEN)-Akt-atrophin interacting protein 4 (AIP4) pathway regulates FLIPS ubiquitination and stability, although the means by which PTEN and Akt were linked to AIP4 activity were unclear. We here report that a second regulator of ubiquitin metabolism, the ubiquitin-specific protease (USP) 8, is a downstream target of Akt, and that USP8 links Akt to AIP4 and the regulation of FLIPS stability and TRAIL resistance. In human GBM xenografts, levels of USP8 correlated inversely with pAkt levels, and genetic or pharmacologic manipulation of Akt regulated USP8 levels in an inverse manner. Over-expression of WT USP8, but not catalytically inactive USP8, increased FLIPS ubiquitination, decreased FLIPS half-life, decreased FLIPS steady-state levels, and decreased TRAIL resistance, while siRNA-mediated suppression of USP8 levels had the opposite effects. Because high levels of the USP8 deubiquitinase correlated with high levels of FLIPS ubiquitination, USP8 appeared to control FLIPS ubiquitination through an intermediate target. Consistent with this idea, over-expression of WT USP8 decreased ubiquitination of the FLIPS E3 ubiquitin ligase AIP4, an event previously shown to increase AIP4-FLIPS interaction, while siRNA-mediated suppression of USP8 increased AIP4 ubiquitination. Furthermore, the suppression of FLIPS levels by USP8 over-expression was reversed by introduction of siRNA targeting AIP4. These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIPS stability and TRAIL sensitivity. PMID:20484045

  20. Advanced Information Processing System (AIPS) proof-of-concept system functional design I/O network system services

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The function design of the Input/Output (I/O) services for the Advanced Information Processing System (AIPS) proof of concept system is described. The data flow diagrams, which show the functional processes in I/O services and the data that flows among them, are contained. A complete list of the data identified on the data flow diagrams and in the process descriptions are provided.

  1. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

    PubMed Central

    Silva, Daniela S.; Pereira, Liliana M. G.; Moreira, Ana R.; Ferreira-da-Silva, Frederico; Brito, Rui M.; Faria, Tiago Q.; Zornetta, Irene; Montecucco, Cesare; Oliveira, Pedro; Azevedo, Jorge E.; Pereira, Pedro J. B.; Macedo-Ribeiro, Sandra; do Vale, Ana; dos Santos, Nuno M. S.

    2013-01-01

    AIP56 (apoptosis-inducing protein of 56 kDa) is a major virulence factor of Photobacterium damselae piscicida (Phdp), a Gram-negative pathogen that causes septicemic infections, which are among the most threatening diseases in mariculture. The toxin triggers apoptosis of host macrophages and neutrophils through a process that, in vivo, culminates with secondary necrosis of the apoptotic cells contributing to the necrotic lesions observed in the diseased animals. Here, we show that AIP56 is a NF-κB p65-cleaving zinc-metalloprotease whose catalytic activity is required for the apoptogenic effect. Most of the bacterial effectors known to target NF-κB are type III secreted effectors. In contrast, we demonstrate that AIP56 is an A-B toxin capable of acting at distance, without requiring contact of the bacteria with the target cell. We also show that the N-terminal domain cleaves NF-κB at the Cys39-Glu40 peptide bond and that the C-terminal domain is involved in binding and internalization into the cytosol. PMID:23468618

  2. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    NASA Astrophysics Data System (ADS)

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-10-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  3. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.

    PubMed

    Barucker, Christian; Bittner, Heiko J; Chang, Philip K-Y; Cameron, Scott; Hancock, Mark A; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W; McKinney, R Anne; Multhaup, Gerhard

    2015-10-29

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically "trapping" low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal.

  4. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

    PubMed Central

    Barucker, Christian; Bittner, Heiko J.; Chang, Philip K.-Y.; Cameron, Scott; Hancock, Mark A.; Liebsch, Filip; Hossain, Shireen; Harmeier, Anja; Shaw, Hunter; Charron, François M.; Gensler, Manuel; Dembny, Paul; Zhuang, Wei; Schmitz, Dietmar; Rabe, Jürgen P.; Rao, Yong; Lurz, Rudi; Hildebrand, Peter W.; McKinney, R. Anne; Multhaup, Gerhard

    2015-01-01

    The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density, and affect long-term potentiation (LTP). We have characterized a short, L-amino acid Aβ-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Aβ42 oligomers, rather than simply inhibiting the aggregation of Aβ monomers into oligomers. Our data show that AIP diminishes the loss of Aβ42-induced synaptic spine density and rescues LTP in organotypic hippocampal slice cultures. Notably, the AIP enantiomer (comprised of D-amino acids) attenuated the rough-eye phenotype in a transgenic Aβ42 fly model and significantly improved the function of photoreceptors of these flies in electroretinography tests. Overall, our results indicate that specifically “trapping” low-n oligomers provides a novel strategy for toxic Aβ42-oligomer recognition and removal. PMID:26510576

  5. Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

    PubMed

    Fisher, Robert D; Chung, Hyo-Young; Zhai, Qianting; Robinson, Howard; Sundquist, Wesley I; Hill, Christopher P

    2007-03-09

    ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form elongated arms that fold back into a "V." The structures also reveal conformational flexibility in the arms that suggests that the V domain may act as a flexible hinge in response to ligand binding. YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of the V, whereas CHMP4/ESCRT-III proteins bind a conserved hydrophobic patch on the Bro1 domain, and both interactions are required for virus budding. ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery.

  6. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.

    PubMed

    Nukaya, Manabu; Lin, Bernice C; Glover, Edward; Moran, Susan M; Kennedy, Gregory D; Bradfield, Christopher A

    2010-11-12

    The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development. In our model of AHR signaling, the receptor is found in a cytosolic complex with a number of molecular chaperones, including Hsp90, p23, and the aryl hydrocarbon receptor-interacting protein (AIP), also known as ARA9 and XAP2. To understand the role of AIP in adaptive and toxic aspects of AHR signaling, we generated a conditional mouse model where the Aip locus can be deleted in hepatocytes. Using this model, we demonstrate two important roles for the AIP protein in AHR biology. (i) The expression of AIP in hepatocytes is essential to maintain high levels of functional cytosolic AHR protein in the mammalian liver. (ii) Expression of the AIP protein is essential for dioxin-induced hepatotoxicity. Interestingly, classical AHR-driven genes show differential dependence on AIP expression. The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not. This differential dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-responsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the targets of the dioxin-induced hepatotoxicity.

  7. ProCS15: a DFT-based chemical shift predictor for backbone and Cβ atoms in proteins

    PubMed Central

    Larsen, Anders S.; Bratholm, Lars A.; Christensen, Anders S.; Channir, Maher

    2015-01-01

    We present ProCS15: a program that computes the isotropic chemical shielding values of backbone and Cβ atoms given a protein structure in less than a second. ProCS15 is based on around 2.35 million OPBE/6-31G(d,p)//PM6 calculations on tripeptides and small structural models of hydrogen-bonding. The ProCS15-predicted chemical shielding values are compared to experimentally measured chemical shifts for Ubiquitin and the third IgG-binding domain of Protein G through linear regression and yield RMSD values of up to 2.2, 0.7, and 4.8 ppm for carbon, hydrogen, and nitrogen atoms. These RMSD values are very similar to corresponding RMSD values computed using OPBE/6-31G(d,p) for the entire structure for each proteins. These maximum RMSD values can be reduced by using NMR-derived structural ensembles of Ubiquitin. For example, for the largest ensemble the largest RMSD values are 1.7, 0.5, and 3.5 ppm for carbon, hydrogen, and nitrogen. The corresponding RMSD values predicted by several empirical chemical shift predictors range between 0.7–1.1, 0.2–0.4, and 1.8–2.8 ppm for carbon, hydrogen, and nitrogen atoms, respectively. PMID:26623185

  8. Time course of information representation of macaque AIP neurons in hand manipulation task revealed by information analysis.

    PubMed

    Sakaguchi, Yutaka; Ishida, Fumihiko; Shimizu, Takashi; Murata, Akira

    2010-12-01

    We used mutual information analysis of neuronal activity in the macaque anterior intraparietal area (AIP) to examine information processing during a hand manipulation task. The task was to reach-to-grasp a three-dimensional (3D) object after presentation of a go signal. Mutual information was calculated between the spike counts of individual neurons in 50-ms-wide time bins and six unique shape classifications or 15 one-versus-one classifications of these shapes. The spatiotemporal distribution of mutual information was visualized as a two-dimensional image ("information map") to better observe global profiles of information representation. In addition, a nonnegative matrix factorization technique was applied for extracting its structure. Our major finding was that the time course of mutual information differed significantly according to different classes of task-related neurons. This strongly suggests that different classes of neurons were engaged in different information processing stages in executing the hand manipulation task. On the other hand, our analysis revealed the heterogeneous nature of information representation of AIP neurons. For example, "information latency" (or information onset) varied among individual neurons even in the same neuron class and the same shape classification. Further, some neurons changed "information preference" (i.e., shape classification with the largest amount of information) across different task periods. These suggest that neurons encode different information in the different task periods. Taking the present result together with previous findings, we used a Gantt chart to propose a hypothetical scheme of the dynamic interactions between different types of AIP neurons.

  9. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein.

    PubMed

    Kang, Byoung Heon; Xia, Fang; Pop, Ramona; Dohi, Takehiko; Socolovsky, Merav; Altieri, Dario C

    2011-05-13

    Survivin is a multifunctional protein with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings of its cytoprotective properties are poorly understood. Here we show that homozygous deletion of the aryl hydrocarbon receptor-interacting protein (AIP), a survivin-associated immunophilin, causes embryonic lethality in mice by embryonic day 13.5-14, increased apoptosis of Ter119(-)/CD71(-) early erythropoietic progenitors, and loss of survivin expression in its cytosolic and mitochondrial compartments in vivo. In import assays using recombinant proteins, AIP directly mediated the import of survivin to mitochondria, thus enabling its anti-apoptotic function, whereas a survivin 1-141 mutant that does not bind AIP was not imported to mitochondria and failed to inhibit apoptosis. AIP-directed mitochondrial import of survivin did not affect cell division, was independent of the organelle transmembrane potential, did not require the chaperone Heat Shock Protein 90 (Hsp90), and was inhibited by cytosolic factor(s) present in normal cells. shRNA knockdown of the mitochondrial import receptor Tom20 abolished mitochondrial import of survivin and sensitized tumor cells to apoptosis, whereas silencing of Tom70 had no effect. Therefore, an AIP-Tom20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of survivin.

  10. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.

    PubMed

    Junio, Hiyas A; Todd, Daniel A; Ettefagh, Keivan A; Ehrmann, Brandie M; Kavanaugh, Jeffrey S; Horswill, Alexander R; Cech, Nadja B

    2013-07-01

    Staphylococcus aureus infections acquired in hospitals now cause more deaths per annum in the US than does HIV/AIDS. Perhaps even more alarming is the rise in community associated methicillin-resistant S. aureus (CA-MRSA) infections, which have spread out of hospital settings and are infecting otherwise healthy individuals. The mechanism of enhanced pathogenesis in CA-MRSA remains unclear, but it has been postulated that high activity in the agr quorum-sensing system could be a contributing factor. The purpose of this study was to develop a quantitative method for analysis of autoinducing peptide I (AIP-I), the activating signal for the agr system in S. aureus. An effective method was developed using ultrahigh performance liquid chromatography (UHPLC) coupled to electrospray ionization mass spectrometry with an LTQ Orbitrap mass spectrometer. Relying on the exceptional resolving power and mass accuracy of this instrument configuration, it was possible to quantify AIP-I directly from the complex growth media of S. aureus cultures with a limit of detection (LOD) of 0.25μM and a linear dynamic range of 2.6 to 63μM. The method was then employed to monitor time-dependent production of AIP-I by S. aureus cultures, and it was observed that AIP-I production reached a maximum and leveled off after approximately 16h. Finally, it was determined that virulence of S. aureus was correlated with AIP-I production in some (but not all) strains analyzed.

  11. Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP.

    PubMed

    Pedersen, Linda Margareth; Lien, Guro Flor; Bollerud, Ingunn; Gjerstad, Johannes

    2005-04-11

    Neuronal events leading to development of long-term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying central hyperalgesia. Here, we examine whether induction of LTP in nociceptive dorsal horn neurons at depths of 80-500 microm from the cord surface can be affected by spinal application of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitor AIP. Extracellular recordings from single neurons in intact urethane anesthetized Sprague-Dawley rats were performed, and the neuronal A-fiber and C-fiber responses after sciatic nerve test pulses were defined according to latencies. A clear LTP of the nociceptive transmission following sciatic nerve high-frequency stimulation (HFS) was observed in single neurons in laminae I-IV of the dorsal horn. The increase in the C-fiber response after HFS was blocked in the presence of 2.0 mM AIP (P < 0.05 HFS group versus AIP + HFS group 2 h after conditioning). However, the C-fiber response was not affected by 2.0 mM AIP alone or by vehicle. Thus, our data show that the neuronal process leading to the induction of LTP in the dorsal horn induced by HFS is clearly inhibited by the specific CaMKII inhibitor AIP. It is concluded that CaMKII may be important for the induction of LTP in single nociceptive dorsal horn neurons.

  12. UAS-NAS Live Virtual Constructive Distributed Environment (LVC): LVC Gateway, Gateway Toolbox, Gateway Data Logger (GDL), SaaProc Software Design Description

    NASA Technical Reports Server (NTRS)

    Jovic, Srboljub

    2015-01-01

    This document provides the software design description for the two core software components, the LVC Gateway, the LVC Gateway Toolbox, and two participants, the LVC Gateway Data Logger and the SAA Processor (SaaProc).

  13. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin.

    PubMed

    Ji, Hee Jung; Yeo, Hee Kyoung; Lee, Nam Hee; Hwang, Jung Suk; Koo, Kyung Ah; Cheong, Seon Woo; Park, Joo Hung; Oh, Gap Soo; Yoon, Chun Sik; Youn, Hyun Joo

    2005-02-01

    Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.

  14. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line

    PubMed Central

    Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip. PMID:27706259

  15. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.

    PubMed

    Fukuda, Takashi; Tanaka, Tomoko; Hamaguchi, Yuriko; Kawanami, Takako; Nomiyama, Takashi; Yanase, Toshihiko

    2016-01-01

    Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a GH3 cell clone (termed GH3-FTY) in which Aip was genetically disrupted, and subsequently investigated its character with respect to growth hormone (Gh) synthesis and proliferation. Compared with GH3, GH3-FTY cells showed remarkably increased Gh production and a slight increase in cell proliferation. Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3. Interestingly, phosphorylated-Stat3 expression in GH3-FTY cells was increased more compared with GH3 cells, suggesting a stronger drive for this mechanism in GH3-FTY. The phenotypes of GH3-FTY concerning Gh overproduction, cell proliferation, and increased Stat3 phosphorylation were significantly reversed by the exogenous expression of Aip. GH3-FTY cells were less sensitive to somatostatin than GH3 cells in the suppression of cell proliferation, which might be associated with the reduced expression of somatostatin receptor type 2. GH3-FTY xenografts in BALB/c nude mice (GH3-FTY mice) formed more mitotic somatotroph tumors than GH3 xenografts (GH3 mice), as also evidenced by increased Ki67 scores. GH3-FTY mice were also much larger and had significantly higher plasma Gh levels than GH3 mice. Furthermore, GH3-FTY mice showed relative insulin resistance compared with GH3 mice. In conclusion, we established a somatotroph cell line, GH3-FTY, which possessed prominent Gh secretion and mitotic features associated with the disruption of Aip.

  16. A Finite-Rate Gas-Surface Interaction Model Informed by Fundamental Computational Chemistry Simulations

    DTIC Science & Technology

    2013-03-31

    jet tests, are inferred from heat flux measurements . This requires an accurate model of the arc-jet flow field and predicted convective heat flux...published an AIAA conference paper in 2007 entitled, “Molecular mechanisms of gas surface interactions in hypersonic flow ” [24]. In this paper, Cozmuta...cristobalite(100)  surface’,  Proceedings  of  the   Rarefied   Gas  Dynamics:  26th  International  Symposium,   AIP  Conf.  Proc

  17. Chemistry at Clusters, Microstructures and Surfaces

    DTIC Science & Technology

    1989-12-01

    Advances in Laser Sciences - II, ed. by M. Lapp. W. C. Stwallev and G. A. Kenney-Wallace, AIP Conf. Proc. 160, 49 3 -D (1987). 17. A. Peremans, J. Darville ...Vol. 1 (Fonds National de la Recherche Scientifique, Brussels, Belgium, 1986), pp. 67-9. 4. A. Peremans, J. Darville , J.-M. Gilles and T. F. George...Limit," Bull. Am. Phys. Soc. 32, 910 (1987). 10. A. Peremans, J. Darville , J.-M. Gilles and T. F. George, "Infrared Laser- Stimulated Catalysis. Theory

  18. Optimisation de fonctionnements de pompe à chaleur chimique : synchronisation et commande du procédé

    NASA Astrophysics Data System (ADS)

    Cassou, T.; Amouroux, M.; Labat, P.

    1995-04-01

    We present the mathematical modelling of a chemical heat pump and the associated simulator. This simulator is able to determine the influence of different parameters (which would be associated to the heat exchanges or to the chemical kinetics), but also to simulate the main operating modes. An optimal management of process represents the objective to reach; we materialize it by a continuous and steady production of the power delivered by the machine. Nous présentons le modèle mathématique d'un pilote de pompe à chaleur chimique et le simulateur numérique correspondant. Ce simulateur est capable de déterminer l'influence de divers paramètres (qu'ils soient liés aux échanges de chaleur ou à la cinétique chimique), mais aussi de simuler les principaux modes de fonctionnement. Une gestion optimale du procédé représente le but à atteindre: une conduite optimisée du système permet, par une gestion des différentes phases, une production continue et stable de la puissance délivrée par la machine.

  19. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.

    PubMed

    Bian, Hui; Yu, Long-Chuan

    2015-07-10

    Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine- dependent protein kinase, which has been implicated in pain modulation at different levels of the central nervous system. The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 3 μg, 6 μg and 12 μg of myristoylated autocamtide-2-inhibitory peptide (AIP), the CaMKII inhibitor, dose-dependently increased the HWL to noxious thermal and mechanical stimulation in rats with mononeuropathy. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and AIP group. Taken together, the results showed that intra-NAc injection of AIP induced significant antinociceptive effects in rats with mononeuropathy, indicating that CaMKII may play an important role in the transmission and/or modulation of nociceptive information in the NAc in rats with mononeuropathy.

  20. Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

    PubMed

    Nord, Karolin H; Magnusson, Linda; Isaksson, Margareth; Nilsson, Jenny; Lilljebjörn, Henrik; Domanski, Henryk A; Kindblom, Lars-Gunnar; Mandahl, Nils; Mertens, Fredrik

    2010-12-07

    Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary adenoma predisposition and multiple endocrine neoplasia type I. MEN1 and AIP displayed a low expression in hibernomas whereas the expression of genes up-regulated in brown fat--PPARA, PPARG, PPARGC1A, and UCP1--was high. Thus, loss of MEN1 and AIP is likely to be pathogenetically essential for hibernoma development. Simultaneous loss of two tumor suppressor genes has not previously been shown to result from a neoplasia-associated translocation. Furthermore, in contrast to the prevailing assumption that benign tumors harbor relatively few genetic aberrations, the present analyses demonstrate that a considerable number of chromosome breaks are involved in the pathogenesis of hibernoma.

  1. The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.

    PubMed

    Le Clorennec, Christophe; Lazrek, Yassamine; Dubreuil, Olivier; Larbouret, Christel; Poul, Marie-Alix; Mondon, Philippe; Melino, Gerry; Pèlegrin, André; Chardès, Thierry

    2016-06-14

    We characterized the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway, leading to cell cycle arrest and apoptosis in vitro and regression of pancreatic and breast cancer in vivo. We found that 9F7-F11 induces rapid HER3 down-regulation. Specifically, 9F7-F11-induced HER3 ubiquitination and degradation in pancreatic, breast and prostate cancer cell lines was driven mainly by the itchy E3 ubiquitin ligase (ITCH/AIP4). Overexpression of the ITCH/AIP4 inhibitor N4BP1 or small-interfering RNA-mediated knockdown of ITCH/AIP4 inhibited HER3 ubiquitination/degradation and PI3K/AKT signaling blockade induced by 9F7-F11. Moreover, 9F7-F11-mediated JNK1/2 phosphorylation led to ITCH/AIP4 activation and recruitment to HER3 for receptor ubiquitination and degradation. ITCH/AIP4 activity was activated by the deubiquitinases USP8 and USP9X, as demonstrated by RNA interference. Taken together, our results suggest that 9F7-F11-induced HER3 ubiquitination and degradation in cancer cells mainly occurs through JNK1/2-dependent ITCH/AIP4 activation.

  2. Recommendations from the Italian Interdisciplinary Working Group (AIMN, AIP, SINDEM) for the utilization of amyloid imaging in clinical practice.

    PubMed

    Guerra, Ugo Paolo; Nobili, Flavio Mariano; Padovani, Alessandro; Perani, Daniela; Pupi, Alberto; Sorbi, Sandro; Trabucchi, Marco

    2015-06-01

    Positron emission tomography (PET) of brain amyloid is a technology that has been approved by Food and Drug Administration and European Medical Agency, but its clinical utility in medical practice requires careful definition. To provide guidance to italian dementia care practitioners, patients, and caregivers, a group of experts from "Associazione Italiana di Medicina Nucleare" (AIMN), "Associazione Italiana di Psicogeriatria" (AIP) and "Società Italiana per lo Studio delle Demenze" (SINDEM) convened the Italian Interdisciplinary Working Group on Amyloid Imaging. The Working Group considered a range of clinical scenarios in which amyloid PET should be recommended. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these recommendations. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific recommended use criteria were agreed to define the types of patients and clinical circumstances in which amyloid PET could be used. Both correct and incorrect uses were considered and formulated. Because both dementia care and amyloid-PET technology are in active development, these recommendations will require periodic reassessment.

  3. WE-H-204-02: Part 1: History and Archives Resources at AIP for AAPM and Its Members.

    PubMed

    Good, G

    2016-06-01

    basic X-ray tube used today in medicine, research and industry. In 1932 Coolidge became Director of the GE Laboratory, then in 1940 Vice-President and Director of Research. In 1941 he was a member of a small committee, appointed by President Franklin D. Roosevelt, to evaluate the military importance of research on uranium. This committee's report led to the establishment of the Manhattan Engineering District for nuclear weapons development during WWII. Coolidge lived to be over 100 years old, he had 83 patents to his credit, numerous awards and honorary degrees, and in 1975 was elected to the National Inventor's Hall of Fame. At the time he was the only inventor to receive this honor in his lifetime. Dr. Coolidge was also the first recipient of the AAPM's highest science award - named in his honor. From notes of a day-long interview with Coolidge's son Lawrence in the mid-1990s, previous biographies, publications, books, GE literature, historic photographs, e.g., a wonderful 1874 photo stereoview card with 1 year old baby "Willie Coolidge", and other artifacts in the author's collection, this presentation will review Dr. Coolidge's amazing life, work, accomplishments and awards. "History and Archives Resources at AIP for AAPM and its Members" Gregory A. Good, Ph.D. - Director, AIP Center for History of Physics Melanie J. Mueller, MLIS - Acting Director, AIP Niels Bohr Library & Archives The American Institute of Physics established the Center for History of Physics and the Niels Bohr Library & Archives in the 1960s. Our shared mission is: To preserve and make known the history of the physical sciences. This talk will explore the many ways that AIP's two history programs support the historical and archival activities of AAPM. Topics will include our ongoing oral history program, web outreach through exhibits and teaching guides, and archiving for AAPM and other Member Societies. We will focus in particular on materials in our collections related to the history of medical

  4. WE-H-204-03: Part 2: History and Archives Resources at AIP for AAPM and Its Members.

    PubMed

    Mueller, M

    2016-06-01

    basic X-ray tube used today in medicine, research and industry. In 1932 Coolidge became Director of the GE Laboratory, then in 1940 Vice-President and Director of Research. In 1941 he was a member of a small committee, appointed by President Franklin D. Roosevelt, to evaluate the military importance of research on uranium. This committee's report led to the establishment of the Manhattan Engineering District for nuclear weapons development during WWII. Coolidge lived to be over 100 years old, he had 83 patents to his credit, numerous awards and honorary degrees, and in 1975 was elected to the National Inventor's Hall of Fame. At the time he was the only inventor to receive this honor in his lifetime. Dr. Coolidge was also the first recipient of the AAPM's highest science award - named in his honor. From notes of a day-long interview with Coolidge's son Lawrence in the mid-1990s, previous biographies, publications, books, GE literature, historic photographs, e.g., a wonderful 1874 photo stereoview card with 1 year old baby "Willie Coolidge", and other artifacts in the author's collection, this presentation will review Dr. Coolidge's amazing life, work, accomplishments and awards. "History and Archives Resources at AIP for AAPM and its Members" Gregory A. Good, Ph.D. - Director, AIP Center for History of Physics Melanie J. Mueller, MLIS - Acting Director, AIP Niels Bohr Library & Archives The American Institute of Physics established the Center for History of Physics and the Niels Bohr Library & Archives in the 1960s. Our shared mission is: To preserve and make known the history of the physical sciences. This talk will explore the many ways that AIP's two history programs support the historical and archival activities of AAPM. Topics will include our ongoing oral history program, web outreach through exhibits and teaching guides, and archiving for AAPM and other Member Societies. We will focus in particular on materials in our collections related to the history of medical

  5. Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence

    PubMed Central

    Moore, Ainsley; Patterson, Christopher; Lee, Linda; Vedel, Isabelle; Bergman, Howard

    2014-01-01

    démence sont aussi présentées. Conclusion Plusieurs recommandations de la Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence intéresseront les médecins de famille. Pour assurer l’utilité des lignes directrices, les médecins de famille devraient participer à toutes les étapes du processus de formulation continu, y compris à la sélection des sujets.

  6. The Lunar dusty plasmas -levitation and transport.

    NASA Astrophysics Data System (ADS)

    Atamaniuk, Barbara; Rothkaehl, Hanna

    Lunar dust can exhibit unusual behavior -due to electron photoemission via solar-UV radiation the lunar surface represents a complex plasma -"dusty plasma". The dust grains and lunar surface are electrostatically charged by the Moon's interaction with the local plasma environ-ment and the photoemission of electrons due to solar UV and X-rays. This effect causes the like-charged surface and dust particles to repel each other, and creates a near-surface electric field. Lunar dust must be treated as a dusty plasma. Using analytic (kinetic (Vlasov) and magnetohydrodynamic theory ) and numerical modeling we show physical processes related to levitation and transport dusty plasma on the Moon. These dust grains could affect the lunar environment for radio wave and plasma diagnostics and interfere with exploration activities. References: 1. Wilson T.L. (1992), in Analysis of Interplanetary Dust, M. Zolensky et al. AIP Conf.Proc. 310, 33-44 (AIP, NY), 2.Wilson T.L."LUNAR DUST AND DUSTY PLASMA PHYSICS".40th Lunar and Planetary Science Conference (2009), 3. Grün E., et al.(1993),Nature 363, 144. 4. Morfill G. and Grün E.(1979), Planet. Space Sci.. 27, 1269, 1283, 5. Manka R. and Michel F. (1971), Proc. 2nd Lun. Sci. Conf. 2, 1717 (MIT Press, Cambridge). 6. Manka R. et al.(1973), Lun. Sci.-III, 504. 7. Barbara Atamaniuk "Kinetic Description of Localized Plasma Structure in Dusty Plasmas". Czechoslovak Journal of Physics Vol.54 C 2004

  7. Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds.

    PubMed

    Tichomirowa, Maria A; Lee, Misu; Barlier, Anne; Daly, Adrian F; Marinoni, Ilaria; Jaffrain-Rea, Marie-Lise; Naves, Luciana A; Rodien, Patrice; Rohmer, Vincent; Faucz, Fabio Rueda; Caron, Philippe; Estour, Bruno; Lecomte, Pierre; Borson-Chazot, Françoise; Penfornis, Alfred; Yaneva, Maria; Guitelman, Mirtha; Castermans, Emily; Verhaege, Catherine; Wémeau, Jean-Louis; Tabarin, Antoine; Fajardo Montañana, Carmen; Delemer, Brigitte; Kerlan, Veronique; Sadoul, Jean-Louis; Cortet Rudelli, Christine; Archambeaud, Françoise; Zacharieva, Sabine; Theodoropoulou, Marily; Brue, Thierry; Enjalbert, Alain; Bours, Vincent; Pellegata, Natalia S; Beckers, Albert

    2012-06-01

    Familial isolated pituitary adenoma (FIPA) occurs in families and is unrelated to multiple endocrine neoplasia type 1 and Carney complex. Mutations in AIP account only for 15-25% of FIPA families. CDKN1B mutations cause MEN4 in which affected patients can suffer from pituitary adenomas. With this study, we wanted to assess whether mutations in CDKN1B occur among a large cohort of AIP mutation-negative FIPA kindreds. Eighty-eight AIP mutation-negative FIPA families were studied and 124 affected subjects underwent sequencing of CDKN1B. Functional analysis of putative CDKN1B mutations was performed using in silico and in vitro approaches. Germline CDKN1B analysis revealed two nucleotide changes: c.286A>C (p.K96Q) and c.356T>C (p.I119T). In vitro, the K96Q change decreased p27 affinity for Grb2 but did not segregate with pituitary adenoma in the FIPA kindred. The I119T substitution occurred in a female patient with acromegaly. p27(I119T) shows an abnormal migration pattern by SDS-PAGE. Three variants (p.S56T, p.T142T, and c.605+36C>T) are likely nonpathogenic because In vitro effects were not seen. In conclusion, two patients had germline sequence changes in CDKN1B, which led to functional alterations in the encoded p27 proteins in vitro. Such rare CDKN1B variants may contribute to the development of pituitary adenomas, but their low incidence and lack of clear segregation with affected patients make CDKN1B sequencing unlikely to be of use in routine genetic investigation of FIPA kindreds. However, further characterization of the role of CDKN1B in pituitary tumorigenesis in these and other cases could help clarify the clinicopathological profile of MEN4.

  8. Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor.

    PubMed

    Guaraldi, Federica; Corazzini, Valentina; Gallia, Gary L; Grottoli, Silvia; Stals, Karen; Dalantaeva, Nadezhda; Frohman, Lawrence A; Korbonits, Márta; Salvatori, Roberto

    2012-12-01

    Familial isolated pituitary adenoma (FIPA), defined as the occurrence of at least two cases of pituitary adenoma in a family that does not exhibit features of syndromic diseases, such as Carney complex or Multiple Endocrine Neoplasia type 1 or 4, is a rare autosomal dominant disease with low penetrance. About 20 % of the families with FIPA harbor inactivating mutation in aryl hydrocarbon receptor-interacting protein gene (AIP) associated with loss of heterozygosity of the same genetic locus (11q13) in the tumor. Rarely different types of extra-pituitary tumors have been described in the setting of AIP mutation-positive FIPA. We present the case of a patient who was diagnosed with acromegaly due to the AIP mutation c.241C>T (p.R81X) at the age of 34 years, and treated by transsphenoidal surgery. At the age of 43 years she was diagnosed with a meningioma, and at age 46 had recurrence of the somatotropinoma. Genetic studies demonstrated loss of the normal allele (by sequencing and microsatellite analysis) in DNA from the pituitary adenoma but not from the meningioma, suggesting a selective involvement of AIP mutation in the pathogenesis of the pituitary adenoma, and a casual association with the meningioma. Further investigations are required to define the exact role of AIP in non-pituitary tumorigenesis.

  9. Acute Intermittent Porphyria (AIP)

    MedlinePlus

    ... Panhematin ® is irritation of the vein used for infusion (phlebitis). This is avoided by slow infusion through a large caliber vein or central line. ... ensuring proper caloric intake, which can include intravenous infusion of sufficient nutrients (glucose and salt). Carbohydrate loading ...

  10. The AIP in 1975

    ERIC Educational Resources Information Center

    Physics Today, 1976

    1976-01-01

    This Annual Report details the activities of the American Institute of Physics in 1975. The Institute placed major emphasis on the expansion of the institute's public-relations and manpower roles. Developments affecting journals and the activities of the Fiscal Branch and Marketing Division are also discussed. (BT)

  11. Progress in Modeling Electron Cloud Effects in HIF Accelerators

    NASA Astrophysics Data System (ADS)

    Cohen, R. H.; Friedman, A.; Molvik, A. W.; Azevedo, A.; Vay, J.-L.; Furman, M. A.; Stoltz, P. H.

    2003-10-01

    Stray electrons can arise in positive-charge accelerators for heavy ion fusion (or other applications) from ionization of gas (ambient or released from walls), or via secondary emission. Their accumulation is affected by the beam potential and duration, and the accelerating and confining fields. We present electron orbit simulations which show the resultant e-cloud distribution; ion simulations with prescribed e-clouds which show the effect on ion beam quality; a gyro-averaged model for including electron dynamics in ion simulations, and its implementation status; and progress in merging the capabilities of WARP (3-D PIC code for HIF) (D.P. Grote, A. Friedman, I. Haber, Proc. 1996 Comp. Accel. Physics Conf., AIP Proc. 391), 51 (1996), with those of POSINST (e-clouds in high-energy accelerators) (M.A. Furman, LBNL-41482/CBP Note 247/LHC Project Report 180, May 20, 1998).

  12. A cationic iridium(III) complex showing aggregation-induced phosphorescent emission (AIPE) in the solid state: synthesis, characterization and properties.

    PubMed

    Shan, Guo-Gang; Zhang, Ling-Yu; Li, Hai-Bin; Wang, Shuang; Zhu, Dong-Xia; Li, Peng; Wang, Chun-Gang; Su, Zhong-Min; Liao, Yi

    2012-01-14

    We report the synthesis and characterization of two cationic iridium(III) complexes with dendritic carbazole ligands as ancillary ligands, namely, [Ir(ppy)(2)L3]PF(6) (1) and [Ir(ppy)(2)L4]PF(6) (2), where L3 and L4 represent 3,8-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)-1,10-phenanthroline and 3,8-bis(3',6'-di-tert-butyl-6-(3,6-di-tert-butyl-9H-carbazol-9-yl)-3,9'-bi(9H-carbazol)-9-yl)-1,10-phenanthroline, respectively. Their photophysical properties have been investigated and compared. The results have shown that complex 2 is aggregation-induced phosphorescent emission (AIPE) active and exhibits the highest photoluminescent quantum yield (PLQY) of 16.2% in neat film among the reported cationic Ir(III) complexes with AIPE activity. In addition, it also enjoys redox reversibility, good film-forming ability, excellent thermal stability as well as off/on luminescence switching properties, revealing its potential application as a candidate for light-emitting electrochemical cells and organic vapor sensing. To explore applications in biology, 2 was used to image cells.

  13. The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes.

    PubMed

    Stratakis, C A; Tichomirowa, M A; Boikos, S; Azevedo, M F; Lodish, M; Martari, M; Verma, S; Daly, A F; Raygada, M; Keil, M F; Papademetriou, J; Drori-Herishanu, L; Horvath, A; Tsang, K M; Nesterova, M; Franklin, S; Vanbellinghen, J-F; Bours, V; Salvatori, R; Beckers, A

    2010-11-01

    The prevalence of germline mutations in MEN1, AIP, PRKAR1A, CDKN1B and CDKN2CI is unknown among pediatric patients with pituitary adenomas (PA). In this study, we screened children with PA for mutations in these genes; somatic GNAS mutations were also studied in a limited number of growth hormone (GH) or prolactin (PRL)-secreting PA. We studied 74 and 6 patients with either isolated Cushing disease (CD) or GH- or PRL-secreting PA, respectively. We also screened four pediatric patients with CD, and four with GH/PRL-secreting tumors who had some syndromic features. There was one AIP mutation (p.Lys103Arg) among 74 CD patients. Two MEN1 mutations that occurred in patients with recurrent or difficult-to-treat disease were found among patients with CD. There was one MEN1 and three AIP mutations (p.Gln307ProfsX104, p.Pro114fsX, p.Lys241X) among pediatric patients with isolated GH- or PRL-secreting PA and one additional MEN1 mutation in a patient with positive family history. There were no mutations in the PRKAR1A, CDKN1B, CDKN2C or GNAS genes. Thus, germline AIP or MEN1 gene mutations are frequent among pediatric patients with GH- or PRL-secreting PA but are significantly rarer in pediatric CD; PRKAR1A mutations are not present in PA outside of Carney complex.

  14. A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans.

    PubMed

    Jain, Rakhi; T, Leenath; Chandran, Jolly; Jayandharan, Giridhara R; Palle, Arpana; Moses, Prabhakar D

    2013-12-01

    Purpura fulminans in the neonatal period due to severe congenital protein C deficiency (protein C activity <1 IU/dl) is a rare autosomal recessive disorder. If untreated, it is fatal. Early identification of such patients may be lifesaving. Acquired deficiency of protein C caused by increased consumption as overt disseminated intravascular coagulation (DIC) and severe infection creates a diagnostic dilemma. Mutation analysis plays a critical role in confirming the diagnosis of the disease and offering prenatal diagnosis. In this report, we describe a newborn who presented with purpura fulminans and DIC, molecular analysis showed a novel c.1048A>T transversion in a homozygous state at codon 350 (Lys>Stop) of protein C (PROC) gene. Prenatal diagnosis in subsequent pregnancy was done which revealed the affected fetus had the same mutation in homozygous form.

  15. Growing Growth curves using PROC MIXED and PROC NLMIXED

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Being able to describe growth appropriately and succinctly is important in many contexts, including biology, epidemiology, and statistics. Various approaches are used varying from differential equations, deterministic modeling, and statistical approaches like regression. Often, with epidemiologic da...

  16. Time-of-flight mass spectrometry of laser exploding foil initiated PETN samples

    NASA Astrophysics Data System (ADS)

    Fajardo, Mario E.; Molek, Christopher D.; Fossum, Emily C.

    2017-01-01

    We report the results of time-of-flight mass spectrometry (TOFMS) measurements of the gaseous products of thin-film pentaerythritol tetranitrate [PETN, C(CH2NO3)4] samples reacting in vacuo. The PETN sample spots are produced by masked physical vapor deposition [A.S. Tappan, et al., AIP Conf. Proc. 1426, 677 (2012)] onto a first-surface aluminum mirror. A pulsed laser beam imaged through the soda lime glass mirror substrate converts the aluminum layer into a high-temperature high-pressure plasma which initiates chemical reactions in the overlying PETN sample. We had previously proposed [E.C. Fossum, et al., AIP Conf. Proc. 1426, 235 (2012)] to exploit differences in gaseous product chemical identities and molecular velocities to provide a chemically-based diagnostic for distinguishing between "detonation-like" and deflagration responses. Briefly: we expect in-vacuum detonations to produce hyperthermal (v˜10 km/s) thermodynamically-stable products such as N2, CO2, and H2O, and for deflagrations to produce mostly reaction intermediates, such as NO and NO2, with much slower molecular velocities - consistent with the expansion-quenched thermal decomposition of PETN. We observe primarily slow reaction intermediates (NO2, CH2NO3) at low laser pulse energies, the appearance of NO at intermediate laser pulse energies, and the appearance of hyperthemal CO/N2 at mass 28 amu at the highest laser pulse energies. However, these results are somewhat ambiguous, as the NO, NO2, and CH2NO3 intermediates persist and all species become hyperthermal at the higher laser pulse energies. Also, the purported CO/N2 signal at 28 amu may be contaminated by silicon ablated from the glass mirror substrate. We plan to mitigate these problems in future experiments by adopting the "Buelow" sample configuration which employs an intermediate foil barrier to shield the energetic material from the laser and the laser driven plasma [S.J. Buelow, et al., AIP Conf. Proc. 706, 1377 (2003)].

  17. Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: a novel gene related to nuclear envelopathies.

    PubMed

    Kayman-Kurekci, Gulsum; Talim, Beril; Korkusuz, Petek; Sayar, Nilufer; Sarioglu, Turkan; Oncel, Ibrahim; Sharafi, Parisa; Gundesli, Hulya; Balci-Hayta, Burcu; Purali, Nuhan; Serdaroglu-Oflazer, Piraye; Topaloglu, Haluk; Dincer, Pervin

    2014-07-01

    We performed genome-wide homozygosity mapping and mapped a novel myopathic phenotype to chromosomal region 1q25 in a consanguineous family with three affected individuals manifesting proximal and distal weakness and atrophy, rigid spine and contractures of the proximal and distal interphalangeal hand joints. Additionally, cardiomyopathy and respiratory involvement were noted. DNA sequencing of torsinA-interacting protein 1 (TOR1AIP1) gene encoding lamina-associated polypeptide 1B (LAP1B), showed a homozygous c.186delG mutation that causes a frameshift resulting in a premature stop codon (p.E62fsTer25). We observed that expression of LAP1B was absent in the patient skeletal muscle fibres. Ultrastructural examination showed intact sarcomeric organization but alterations of the nuclear envelope including nuclear fragmentation, chromatin bleb formation and naked chromatin. LAP1B is a type-2 integral membrane protein localized in the inner nuclear membrane that binds to both A- and B-type lamins, and is involved in the regulation of torsinA ATPase. Interestingly, luminal domain-like LAP1 (LULL1)-an endoplasmic reticulum-localized partner of torsinA-was overexpressed in the patient's muscle in the absence of LAP1B. Therefore, the findings suggest that LAP1 and LULL1 might have a compensatory effect on each other. This study expands the spectrum of genes associated with nuclear envelopathies and highlights the critical function for LAP1B in striated muscle.

  18. Auxotrophic markers pyrF and proC can replace antibiotic markers on protein production plasmids in high-cell-density Pseudomonas fluorescens fermentation.

    PubMed

    Schneider, Jane C; Jenings, Annika F; Mun, Deborah M; McGovern, Patricia M; Chew, Lawrence C

    2005-01-01

    The use of antibiotic-resistance genes as selectable markers in transgenic organisms is coming under increased scrutiny, for fear that they may spread to human pathogens, thereby reducing the effectiveness of antibiotic therapy. A current Pseudomonas fluorescens protein expression system uses a tetracycline resistance gene (tetR/tetA) to maintain an expression plasmid under control of a repressible promoter and a kanamycin resistance gene (kanR) to maintain a plasmid carrying a repressor gene. We investigated using auxotrophic markers to replace these two antibiotic resistance genes: pyrF (encoding orotidine-5'-phosphate decarboxylase) in place of tetR/tetA and proC (encoding pyrroline-5-carboxylate reductase) in place of kanR, complementing their respective precise chromosomal deletions created by allele exchange using a suicide vector carrying pyrF as a counterselectable marker. The resulting strains, devoid of antibiotic-resistance genes, were shown to achieve high productivity of nitrilase and thermostable alpha-amylase equal to that of the former antibiotic-resistant production host. The production plasmids were stable. The pyrF (uracil-dependent) background of the production host strain also allows us to sequentially alter the genome to incorporate other desired genomic changes, deletions, or insertions using 5'-fluoroorotic acid counterselection, restoring the selectable marker after each step.

  19. Développement d'outils de mesure pour l'amélioration du procédé d'impression offset

    NASA Astrophysics Data System (ADS)

    Boumaïza, K.; Baudin, G.; Catusse, R.; Viallet, A.

    1999-03-01

    The offset printing process rests primarily on the balance between ink and damping solution. However, this balance remains difficult to realize. The corresponding wastes of time and into consumable (ink, paper and damping solution) are harmful for the industrialist, the consumer and the environment. The main feature of this work is to control and thus to optimize these flux. With this intention, two optical sensors functioning in reflection were developed. A laser with receiving photodiode for the control of damping solution film thickness, and an optical fiber related to a photoelectric sensor for control of ink film thickness. The current study aims at the calibration of these two sensors for respectively the control of water and ink flux in the offset press. Le procédé d'impression offset repose essentiellement sur l'équilibre entre la solution de mouillage et l'encre. Toutefois, cet équilibre reste une tâche difficile à réaliser. Les pertes en temps et en consommables (encre, papier, solution de mouillage) correspondantes sont nuisibles à la fois pour l'industriel, le consommateur et l'environnement. L'objectif de ce travail est de contrôler et donc d'optimiser ces flux pour un tirage donné. Pour ce faire, deux capteurs de type optique fonctionnant en réflexion ont été développés. Un laser avec photodiode réceptrice pour le contrôle du film de solution de mouillage, et une fibre optique liée à un capteur photoélectrique pour le contrôle du film d'encre. L'étude actuelle vise la mise en ouvre et l'étalonnage de ces deux capteurs pour la mesure et le contrôle des films respectifs d'eau et d'encre dans la presse offset.

  20. Semiclassical Planetology: a progress report

    NASA Astrophysics Data System (ADS)

    Celebonovic, V.

    1999-12-01

    Work on planetary internal structure has started in Yugoslavia in the early sixties.It was initiated by P.Savic and R.Kasanin,who have jointly developed a theory of the behaviour of materials under high pressure.By its physical basis,this theory is semiclassical,because it is based on classical physics combined with some quantum mechanical results.The calculations in the theory ( both laboratory and planetological) are baed on ths idea that high pressure leads to excitation and ionisation of atoms and/or molecules which make up the specimen. In this paper we shall briefly present the main ideas of this theory,and then discuss its planetological applications. References P.Savic and V.Celebonovic: 1994,AIP Conf.Proc.,vol.309,p.53. V.Celebonovic: 1999,preprint cond-mat/9906027

  1. Feasibility study for reduction of the screening current induced field in a 2G high temperature superconducting coil

    NASA Astrophysics Data System (ADS)

    Hwang, Y. J.; Jang, J. Y.; Ahn, M. C.; Park, Y. G.; Lee, S. G.

    2016-10-01

    This paper reports the effects of thermal energy on reducing the overshoot of the current sweep cycle method to reduce the screening current-induced field (SCF) in a 2G high temperature superconducting (HTS) coil. A disadvantage of the current sweep cycle method is the necessity for large overshoot in the coil current. For a 2G HTS coil, excessive overshooting of the coil current is undesirable (Yanagisawa et al 2012 AIP Conf. Proc. 1434 1373-8). In an effort to circumvent this overshooting problem, the thermal energy effect was investigated in combination with the current sweep cycle method based on experiments in this study. The experimental results show that greater SCF reduction in the HTS coil was obtained upon increasing thermal energy by heater current.

  2. The AIP career pathways project

    NASA Astrophysics Data System (ADS)

    Sauncy, Toni; Redmond, Kendra; Czujko, Roman

    2015-12-01

    An average 40% of all physics baccalaureate degree recipients in the United States go directly into the work-force rather than entering graduate school. Departments aiming to build robust programs must prepare all students for a broad range of career paths, but the default focus is typically on preparing students for advanced physics degrees. Under-graduate physics programs, with effective recruitment, retention, and appropriate preparation of students, have the potential to add qualified individuals to the STEM workforce. We present results from an investigation to understand, compile, and disseminate effective practices for preparing undergraduate physics students to enter the STEM workforce upon graduation.

  3. Employment Survey 1980. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    The employment status of 1980 degree recipients in physics and astronomy was surveyed. For physics degree recipients, the majority of bachelors and masters required two months or less to accept suitable employment, while the majority of doctoral graduates required three months or longer. Information is presented on changes in occupational status…

  4. Employment Survey 1984. AIP Report.

    ERIC Educational Resources Information Center

    Ellis, Susanne D.

    The employment status of 1984-1985 degree recipients in physics and astronomy was surveyed. Information is presented on changes in occupational status of physics and astronomy degree recipients between summer of 1984 and the following winter. The characteristics of graduates of both fields who were employed full-time or undertaking postdoctoral…

  5. On Improved Least Squares Regression and Artificial Neural Network Meta-Models for Simulation via Control Variates

    DTIC Science & Technology

    2016-09-15

    optimization techniques. In 1998 Winter Simul. Conf. Proc. ( Cat . No.98CH36274), volume 1, pages 151–158. IEEE, 2013. [7] Adedeji B. Badiru and David B. Sieger...Conf. Proc. ( Cat . No.98CH36274), volume 1, pages 167–174. IEEE, 1998. [10] Russell R. Barton. Metamodels for simulation input-output relations. Proc...Control variates techniques for Monte Carlo simulation. In Proc. 2003 Int. Conf. Mach. Learn. Cybern. (IEEE Cat . No.03EX693), vol- ume 1, pages 144

  6. Observation-Based Dissipation and Input Terms for Spectral Wave Models, with End-User Testing

    DTIC Science & Technology

    2011-09-01

    Testing Alexander V. Babanin Swinburne University of Technology, PO Box 218, Hawthorn, Victoria 3140 Australia phone: +61-3-9214-8033 fax: +61...and Ocean Eng. Conf. and 10th Australasian Port and Harbour Conf., 20-23 September 2005, Adelaide, South Australia, Eds. M.Townsend and D.Walker...weather conditions. Proc. 20th Australasian Coastal and Ocean Eng. Conf. and 13th Australasian Port and Harbour Eng. Conf., 28-30 September 2009

  7. Electromagnetically driven, fast opening and closing gas jet valve

    NASA Astrophysics Data System (ADS)

    Krishnan, Mahadevan; Elliott, Kristi Wilson; Geddes, C. G. R.; van Mourik, R. A.; Leemans, W. P.; Murphy, H.; Clover, M.

    2011-03-01

    The design and performance are presented of an electromagnetically driven gas valve [M. Krishnan, J. Wright, and T. Ma, Proceedings of the 13th Advanced Accelerator Concepts Workshop, Santa Cruz, CA, AIP Conf. Proc. No. 1086 (AIP, New York, 2008)] that opens in <100μs, closes in <500μs, and can operate at pressures of ˜1000psia to drive supersonic nozzles. Such a valve has applications to laser-plasma accelerators, where the fast opening and closing would allow sharper edges to the flow and also allow higher rep-rate operation without loading the vacuum chamber. The valve action is effected by a flyer plate accelerated by the electromagnetic impulse of a low inductance, spiral wound, strip-line coil driven by a capacitor. Gas flows out of the valve when the seal between this flyer plate and the valve seat is broken. The electromagnetic force greatly exceeds the restoring forces provided by a spring and the gas pressure against the valve seat. Piezoresistive sensor and laser interferometer measurements of flow show that the valve opens in ˜100μs for all pressures up to 800 psia. The closing time is 500μs, set by the spring constant and mass. The prototype valve has been operated with helium at 0.5 Hz and at 500 psia for ˜1 hour at a time with no cooling.

  8. Noninvasive Online Measurement of Genome Lengths of Mammalian Tissues in Bulk by 14 MeV Neutron Atometry

    NASA Astrophysics Data System (ADS)

    Maglich, Bogdan; Radovic, Anna; Druey, Christian

    2012-10-01

    Genome length, L=, no. of DNA nucleotide base pairs in cell of bovine (b) and porcine (p) tissues, closest to human genome, were hitherto measured by genomic sequencing Lb=3, Lp=2.7 Giga base pairs [1,2] (Gbp) errors not given. - We report measurements of Lb/Lp and Lb, Lp without sequencing by atometry [3,4]. No. of O and C atoms, N, in nucleotide molecules, was obtained from prompt γ rate, G, emitted in inel. scatt. 14 MeV neutrons, with nuclei of C, O, in nucleotide molecule. Since G prop. N, Lb/Lp=Gb/Gp. p and b meat was irradiated for 30'. From msd G we obtained Lb /Lp=1.28±0.02 16% greater than [1,2]. We got absolute Lb=1.65/f, Lp=1.28/f Gbp, 0.3AIP Conf. Proc. 796,431(2005); http://link.aip.org/link/?APCPCS/796/431/1

  9. L’explosion intravésicale au cours des procédures de résection endoscopique: Un incident dangereux qui peut être évité

    PubMed Central

    Anzaoui, Jihad El; Abakka, Najib; El harrech, Younes; Ghoundale, Omar; Touiti, Driss; Lahkim, Mohammed; Fihri, Jawad Fassi; Bakzaza, Walid; Mejdane, Abdelhadi

    2013-01-01

    Résumé Les explosions survenant au cours des manœuvres endoscopiques urologiques sont rares et dangereuses. Elles sont dues à une production d’hydrogène par hydrolyse de l’eau lors des procédés de coagulation et de section. L’hydrogène devient très combustible une fois mélangé avec l’oxygène ambiant. Nous rapportons un cas d’explosion intravésicale au cours d’une résection transurethrale d’une tumeur de la vessie et nous exposons, par une revue de littérature, les différentes théories physiopathologiques et les moyens de prévention. PMID:23914274

  10. Distribution of Nanoflares as Spatially Resolved Current Sheets in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Ng, C. S.; Lin, L.

    2014-05-01

    In a recent numerical study [Ng et al., Astrophys. J. 747, 109, 2012], based on a three-dimensional model of coronal heating using reduced magnetohydrodynamics, we have obtained scaling results of heating rate versus Lundquist number S based on a series of runs in which random photospheric motions are imposed for hundreds to thousands of Alfvén time in order to obtain converged statistical values. The heating rate found in these simulations saturates to a level that is independent of S in the high S limit and is consistent with the required level for coronal heating. In a previous study based on the total heating rate time series [Ng and Lin, AIP Conf. Proc. 1500, 38, 2012] in these simulations, we have also calculated heating events distributions, which are consistent with observations but do not support the nanoflares scenario [Parker, Astrophys. J. 330, 474, 1988]. This method has a limitation of not distinguishing individual heating events. We now extend this analysis to investigate the distribution of energy release events defined as spatially resolved current sheets [Lin et el., ASP Conf. Ser. 474, 159, 2013]. We report preliminary results and compare to results obtained using only time-series analysis.

  11. Study of Surface Enhanced Raman Scattering of Alizarin and Crystal Violet Dyes

    NASA Astrophysics Data System (ADS)

    Gopal, Ram; Swarnkar, Raj Kumar

    2010-06-01

    Surface enhanced Raman scattering (SERS) plays a vital role in analytical chemistry to characterize ultra trace quantity of organic compounds and biological samples. Two mechanisms have been considered to explain the SERS effect. The main contribution arises from a huge enhancement of the local electromagnetic field close to surface roughness of the metal structures, due to the excitation of a localized surface plasmon, while a further enhancement can be observed for molecules adsorbed onto specific sites when resonant charge transfer occurs. SERS signals have been observed from adsorbates on many metallic surfaces like Ag, Au, Ni, Cu etc. Additionally, metal oxide nanoparticles also show SERS signals It has now been established that SERS of analyte material is highly dependent on the type of substrate involved. Many types of nanostructures like nanofilms, nanorods, nanospheres etc. show highly efficient SERS signals. In particular, there are two routes available for the synthesis of these nanomaterials: the chemical route and the physical route. Chemical route involves many types of reducing agents and capping agents which can interfere in origin and measurement of these signals. The physical route avoids these anomalies and therefore it is suitable for the study of SERS phenomenon. Pulsed laser ablation in liquid medium is an excellent top down technique to produce colloidal solution of nanoparticles with desired shape and size having surface free from chemical contamination, which is essential requirement for surface application of nanoparticles. The present work deals with the study of SERS of Crystal violet dye and Alizarin group dye on Cu@ Cu_2O and Ag colloidal nanoparticles synthesized by pulsed laser ablation. M. Fleishchmann, P. J. Hendra, and A. J. McQuillian Chem. Phys. Lett., 26, 163, 1974. U. Wenning, B. Pettinger, and H. Wetzel Chem. Phys. Lett., 70, 49, 1980. S. C. Singh, R. K. Swarnkar, P. Ankit, M. C. Chattopadhyaya, and R. Gopal AIP Conf. Proc

  12. Propriétés électriques et optiques de couches minces de ZnO et ZnO dopé à l'indium, obtenues par le procédé Pyrosol

    NASA Astrophysics Data System (ADS)

    Tiburcio-Silver, A.; Joubert, J. C.; Labeau, M.

    1992-07-01

    Undoped and indium-doped ZnO thin films deposited by the Pyrosol process onto soda-lime glass substrates were electrically and optically characterized. Resistivities as low as 2× 10^{-3} Ω.cm. Hall mobilities as high as 21 cm^2 V^{-1} s^{-1} and effective carrier concentrations as high as 1 × 10^{20} cm^{-3} have been obtained. Electron concentrations are always lower than indium contents on the films. Average optical transmissions on the whole visible range as high as 85% for the best conductive films have been obtained. Refractive index of layers is modified by the growth temperature and indium doping, been less dependent on doping for high deposition temperatures (better crystallinity). Haacke's figure of merit up to 5× 10^{-3} Ω^{-1} in a 500 nm thick films were obtained. Indium doping improves the time-dependent stability of the electrical properties of ZnO conducting films. Des couches minces de ZnO conducteur non dopé et dopé à l'indium, élaborées par le procédé Pyrosol sur des substrats en verre sodocalcique, ont été caractérisées du point de vue électrique et optique. Résistivités de 2× 10^{-3} Ω.cm, mobilités Hall de 21 cm^2 V^{-1} s^{-1}, et concentrations effectives des porteurs de l'ordre de 1 × 10^{20} cm^{-3} ont été obtenues. La concentration des porteurs mesurée par effet Hall est toujours inférieure à la concentration d'indium dans la couche. La transmission optique moyenne dans le visible atteint 85 % pour les films possédant la meilleure conductivité. La température de dépôt et le dopage à l'indium modifient l'indice de réfraction ; celui-ci dépend moins du dopage à des températures de dépôt élevées (meilleure cristallinité). Les meilleurs facteurs de mérite, \\varnothing_TC, sont de l'ordre de 5× 10^{-3} Ω^{-1} (épaisseur du film 5 000 Å environ). Le dopage à l'indium améliore la stabilité dans le temps des propriétés électriques des couches de ZnO.

  13. Skin Color-Based Video Segmentation under Time-Varying Illumination

    DTIC Science & Technology

    2003-03-25

    Face and Gesture Recognition , pp. 379–384, 1996. [15] R. Kjeldsen and J. Kender. Finding skin in color images. Proc. International Conf. on Automatic...Face and Gesture Recognition , pp. 312–317, 1996. [16] M. Storring, H.J. Andersen, and E. Granum. Skin colour detection under changing lighting...Object oriented face detection using range and color information. Proc. International Conf. on Automatic Face and Gesture Recognition , pp. 76–81, 1998

  14. Building and Verifying a Predictive Model of Interruption Resumption

    DTIC Science & Technology

    2012-03-01

    willingly anthropomorphize robots with very little evi- dence that the robot can think or act for itself [31]–[33]. We hoped that the combination of following...equal: The design and perception of humanoid robot heads,[ in Proc. 4th Int. Conf. Designing Trafton et al. : Building and Verifying a Predictive Model of...models of humanoid robots ,[ Proc. IEEE Int. Conf. Robot . Autom., 2005, pp. 2767–2772. [34] T. Fawcett, BAn introduction to ROC analysis,[ Pattern

  15. Research in Stochastic Processes.

    DTIC Science & Technology

    1985-09-01

    appear. G. Kallianpur, Finitely additive approach to nonlinear filtering, Proc. Bernoulli Soc. Conf. on Stochastic Processes, T. Hida , ed., Springer, to...Nov. 85, in Proc. Bernoulli Soc. Conf. on Stochastic Processes, T. Hida , ed., Springer, to appear. i. Preparation T. Hsing, Extreme value theory for...1507 Carroll, R.J., Spiegelman, C.H., Lan, K.K.G., Bailey , K.T. and Abbott, R.D., Errors in-variables for binary regression models, Aug.82. 1508

  16. Signal Processing Algorithms.

    DTIC Science & Technology

    1983-10-13

    determining the solu- tion using the Moore - Penrose inverse . An expression for the mean square error is derived [8,9]. The expression indicates that...Proc. 10. "An Iterative Algorithm for Finding the Minimum Eigenvalue of a Class of Symmetric Matrices," D. Fuhrmann and B. Liu, submitted to 1984 IEEE...Int. Conf. Acous. Sp. 5V. Proc. 11. "Approximating the Eigenvectors of a Symmetric Toeplitz Matrix," by D. Fuhrmann and B. Liu, 1983 Allerton Conf. an

  17. Optical Data Processing for Missile Guidance.

    DTIC Science & Technology

    1984-11-21

    so 0 ~16. D. Casasent, ’Unified Synthetic Discrimninant Function Computational Formulation’, Applli 02Ltics, Vol. 23, pp. 1020-1827 (May 1084). 17...34Wavefront array Conf II, NASA Langley Research Center, Hampto,, VA, Aug processors Architecture, language , and applications," in Proc 1983 Conf on Advanced

  18. Enrollments and Degrees Report. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    In fall 1999, the 762 degree-granting physics departments in the United States were asked to provide information on their current enrollments and recent degrees, and data were received from 93% of the departments. The number of individuals receiving physics bachelor's degrees was at a 40-year low, with 3,646 degrees conferred in the class of 1999.…

  19. Graduate Student Report, 1997. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.

    The 1990s have seen change in the populations of graduate students in physics departments across the country. The Graduate Student Survey captures demographic characteristics of approximately 10,600 physics and astronomy students who were enrolled in the 1996-97 academic year. It describes the students' sources of support, areas of specialization,…

  20. Physics Bachelors with Master's Degrees. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie

    This report provides information about holders of bachelor's degrees in physics who went on to earn master's degrees and were employed at the time of the survey (completed by spring 1999). This is the second report based on data collected from people who earned bachelor's degrees between 1990 and 1993, but it is the first time the American…

  1. Physics Academic Workforce Report, 2000. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie; Czujko, Roman

    This report discusses trends in the physics academic workforce and the implications of these trends for the future academic job market. In March 2000, a survey was sent to 766 U.S. physics departments that grant at least a bachelor's degree in physics, and 725 responses were received, a response rate of 95%. Degree-granting physics departments in…

  2. Physics Academic Workforce Report, 2002. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie; Nies, Kimberley

    This report discusses trends in the physics academic workforce and the implications of these trends for the future academic job market. Data are from a survey of physics departments that was completed by 722 departments, a response rate of 94%. The number of physics faculty increased almost 5% since 2000, and much of this growth resulted from…

  3. Enrollments and Degrees Report. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    This report presents the results of a fall 1999 survey of U.S. colleges and universities that offer doctoral, master's, and bachelor's degrees in physics and astronomy, focusing on degree production and current student enrollment. Highlighted are the following: (1) after four years of significant declines, physics bachelor's degrees conferred in…

  4. Women in Physics, 2000. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie

    This report describes how the representation of women in physics has changed, presenting data comparing the representation of women in physics to the representation of women in other fields and in academics overall. Highlights include: an increasingly large number of girls have some exposure to physics by taking it in high school; women's…

  5. Enrollments and Degrees Report. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    In fall 2002, the American Institute of Physics asked the 735 physics departments, the 34 combined physics and astronomy departments, and the 37 separate astronomy departments in the United States to provide information on both their current student enrollments and the degrees they conferred in the previous academic year. Data were received from…

  6. Enrollments and Degrees Report. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    In fall 2000, the 770 degree-granting physics departments in the United States were asked to provide information on their current enrollments and recent degrees granted, and responses were received from 98% of the departments. Findings show that the number of individuals receiving physics bachelors degrees increased substantially after a decade of…

  7. Sound speed and oscillation frequencies for a solar model evolved with Los Alamos ATOMIC opacities

    NASA Astrophysics Data System (ADS)

    Guzik, Joyce Ann; Fontes, Christopher; Walczak, Przemyslaw; Wood, Suzannah R.; Mussack, Katie

    2015-08-01

    Los Alamos has calculated a new generation of radiative opacities for elements with atomic number Z=1-30 with improved physics input, updated atomic data, and finer temperature grid to replace the Los Alamos LEDCOP opacities released in the year 2000. We calculate the evolution of a standard solar model including these new opacities, and compare with a model evolved using the Lawrence Livermore National Laboratory OPAL opacities released about 1996. We use the solar abundance mixture of Asplund, Grevesse, Sauval, and Scott (2009), including 2015 updates. The Los Alamos ATOMIC opacities (Colgan et al. 2013a,b) are somewhat higher than those of OPAL for temperatures and densities near the base of the solar convection zone. We compare the calculated nonadiabatic solar oscillation frequencies and solar interior sound speed to observed frequencies and helioseismic inferences. We discuss the potential for increased opacities to partially mitigate the ‘solar abundance problem’.References:J. Colgan, D.P. Kilcrease, N.H. Magee, Jr., G.S.J. Armstrong, J. Abdallah, Jr., M.E. Sherrill, C.J. Fontes, H.L. Zhang and P. Hakel, Eighth International Conference on Atomic and Molecular Data and their Applications: ICAMDATA, Gaithersburg, MD 2012, AIP Conf. Proc. No. 1545, (AIP, New York, 2013a), pp. 17-26.J. Colgan, D.P. Kilcrease, N.H. Magee, Jr, G.S.J. Armstrong, J. Abdallah, Jr., M.E. Sherrill, C.J. Fontes, H.L. Zhang and P. Hakel, High Energy Density Physics 9, 369 (2013b).

  8. Magnetism in EuBCO and YBCO vortex states near and below Tc

    NASA Astrophysics Data System (ADS)

    Schwartz, R.; Browne, M. C.; Boekema, C.

    2012-02-01

    By means of MaxEnt-μSR [1] analysis, we investigate transverse field μSR data [2] of EuBa2Cu3O7-δgEuBCO; Tc = 93 K). Our focus is on a temperature interval near Tc to search for precursor effects, [3] and for predicted [4a] pseudogap loop currents above and below Tc, already observed [4b] above Tc for GdBCO. Further, we continue to study the field-direction dependence of the predicted [5a] and observed [5b] antiferromagnetism (AF) below 0.5Tc for the vortex states in c-axis-oriented YBCO. This AF in and near the vortex cores is likely three-dimensional. In sum, magnetic roots of cuprate superconductivity are well plausible. Research is supported by LANL-DOE, REU-NSF and AFC. [4pt] [1] C Boekema and MC Browne, AIP Conf Proc #1073 (2008) 260.[0pt] [2] DW Cooke et al, Phys Rev B 39 (1989) 2748.[0pt] [3] B Aguilar, C Boekema et al, Bull Am Phys Soc 37 (1992).[0pt] [4a] CM Varma, Phys Rev Lett 83 (1999) 3538.[0pt] [4b] T Songatikamas et al, J Supercond & Novel Magn 23 (2010) 793.[0pt] [5a] S-C Zhang, Science 275 (1997) 1089; H-D Chen et al, Phys Rev B70 (2004) 024516.[0pt] [5b] C. Boekema et al, J Phys Conf Series, 150 (2009) 052022. http://jpcs.iop.org/LT25

  9. Head Pose Estimation Without Manual Initialization

    DTIC Science & Technology

    2000-01-01

    time face tracking and gesture recognition . In Proc. International Joint Conference on Artificial Intelligence, volume 2, pages 1525-1530, August 1997...illumination-insensitive head orientation estimation. In Proc. of Int’l Conf on Face and Gesture Recognition , Grenoble, France, March 2000.

  10. A Model for Fast Ion Emission from Metal Deuterides

    NASA Astrophysics Data System (ADS)

    Hagelstein, Peter

    2000-03-01

    There have been numerous claims during the past ten years of the observation of a variety of anomalies in metal deuterides. One such anomaly involves the emission of fast (MeV) alpha from PdD as reported by G. Chambers and colleagues at NRL in the early 1990s. A related effect is the emission of a variety of low mass fast ions from TiD reported by groups led by G. Chambers and by F. E. Cecil (Colorado School of Mines) et al(F. E. Cecil, H. Liu, D. Beddingfield and C. S. Galovich, in Anomalous Nuclear Effects in Deuterium/Solid Systems, AIP Conf. Proc.) 228, p. 383 (1990).. We have recently examined a theoretical model for this effect. We propose a second order off-resonant reaction in which fusion reactions are coupled to optical phonons, and then the optical phonon excitation is dipole-coupled to nuclear ionization. Such a model gives reaction products and energies which appear to be in agreement with experiment.

  11. Modification of the D2 radial wavefunction by near resonant compact states

    NASA Astrophysics Data System (ADS)

    Hagelstein, Peter L.

    2003-03-01

    We have proposed that phonon exchange can occur in the presence of a highly excited optical phonon mode during a dd-fusion reaction. We have also suggested (P. L. Hagelstein, Bull. APS 45, 235 (2000)) at new second-order site-other-site reactions can occur when the energy of a fusion reaction is transferred elsewhere. Fast particle ejecta from the experiments of Chambers( G. P. Chambers, et al, J. Fusion Energy, Vol. 9, p. 281 (1990).) and of Cecil (F. E. Cecil, et al, AIP Conf. Proc. Vol. 228, p. 383 (1990).) appear to be consistent with such a mechanism, in which a dd-fusion reaction at one site is coupled to a disintegration at another site. The dominant process of this type is the null reaction in which dd-fusion is coupled to He-4 dissociation. This process can lead to compact dd-states(P. L. Hagelstein, Bull. APS 2001), and is consistent with the Kasagi experiment(J. Kasagi et al, J. Phys. Soc. Japan 64, 777 (1995). ). We find that compact states near resonance with the molecular D2 states changes the radial wavefunction at small r.

  12. Gas Phase Rovibrational Spectroscopy of Dmso, Part II: Towards the Terahertz Observation of 4-FOLD Clusters

    NASA Astrophysics Data System (ADS)

    Cuisset, Arnaud; Martin-Drumel, Marie-Aline; Hindle, Francis; Mouret, Gael; Sadovskii, Dmitrii A.

    2013-06-01

    Benefiting of the exceptional properties of the AILES synchrotron beamline, the gas phase Far-IR spectrum of DMSO has been recorded and resolved. The rovibrational analysis allowed to discover a new rotational behaviour for a polyatomic molecule: the gyroscopic destabilization. In order to explain this phenomenon, we looked for four-fold energy clusters in the high resolution ground state THz spectrum of DMSO recorded with a sub-THz spectrometer based on a frequency multiplication chain. Pure rotational lines in the 5 lowest vibrationnally excited levels have been recorded below 700 GHz. With near 1000 rotational transitions assigned, high quantum numbers have been reached allowing to discover sequence of four-fold clusters in the out of plane bending mode of DMSO and to study the vibrational dependence of an unusual rotational dynamics. J. B. Brubach et al., AIP Conf. Proc., 1214, (81), 2010. A. Cuisset, L. Nanobashvili, I. Smirnova, R. Bocquet, F. Hindle, G. Mouret, O. Pirali, P. Roy, D. Sadovskii,Chem. Phys. Lett., 492,(30),2010 A. Cuisset, O. Pirali, D. Sadovskii,Phys. Rev. Lett., 109,(094101), 2012. G. Mouret, M. Guinet, A. Cuisset, L. Croizet, S. Eliet, R. Bocquet, F. Hindle, IEEE Sensors Journal, 13, 1, 2013.

  13. Optimal computation of guided wave propagation and scattering in pipeworks comprising elbows: Numerical and experimental validations and parametric studies

    NASA Astrophysics Data System (ADS)

    El Bakkali, M.; Lhémery, A.; Chapuis, B.; Berthelot, F.; Grondel, S.

    2015-03-01

    Simulation tools of guided wave (GW) examination are developed at CEA to help inspection design and results interpretation. In a previous paper [M. El Bakkali, A. Lhémery, V. Baronian and F. Berthelot, (AIP Conf. Proc. 1581), pp. 332-9 (2014)], a model was developed to deal with GW propagation in elbows, GW scattering at the junction of a straight and a curved guides and GW multiple-scattering by an elbow joined to two straight pipes. The method is computationally optimal: many results are obtained by fast post-processing. Modes in the straight and curved guides are computed once by the semi-analytic finite element method; this implies solving two systems of equations over their shared cross-section meshed by FE. Scattering at a junction of straight and curved pipes requires computing surface integrals over the same section for applying the mode-matching method. For varying elbow angle, computing scattering coefficients of the straight-curved-straight double junction requires multiplying scattering matrices local to one junction with analytic propagation matrices in the curved guide that are angle-dependent. The aim here is twofold. First, the model is validated by comparison of its predictions with results computed by the finite element method and with measurements. Second, the model is used for parametric studies made easy by its computing efficiency.

  14. Compound-nuclear reaction cross sections via the Surrogate method: considering the underlying assumptions

    NASA Astrophysics Data System (ADS)

    Escher, Jutta; Dietrich, Frank

    2006-10-01

    The Surrogate Nuclear Reactions approach makes it possible to determine compound-nuclear reaction cross sections indirectly. The method has been employed to determine (n,f) cross sections for various actinides, including unstable species [1-4]; other, primarily neutron- induced, reactions are being considered also [5,6]. The extraction of the sought-after cross sections typically relies on approximations to the full Surrogate formalism [7]. This presentation will identify and critically examine the most significant assumptions underlying the experimental work carried out so far. Calculations that test the validity of the approximations employed will be presented. [1] J.D. Cramer and H.C. Britt, Nucl. Sci. and Eng. 41, 177(1970); H.C. Britt and J.B. Wilhelmy, ibid. 72, 222(1979) [2] M. Petit et al, Nucl. Phys. A735, 345(2004) [3] C. Plettner et al, Phys. Rev. C 71, 051602(2005); J. Burke et al, Phys. Rev. C. 73, 054604(2006) [4] W. Younes and H.C. Britt, Phys. Rev. C 67, 024610(2003); 68, 034610(2003) [5] L.A. Bernstein et al, AIP Conf. Proc. 769, 890(2005) [6] J. Escher et al, Nucl. Phys. A758, 43c(2005) [7] J. Escher and F.S. Dietrich, submitted (2006)

  15. Radiation-Hydromagnetic Models of a Z-Pinch Implosion with an Axial Magnetic Field

    NASA Astrophysics Data System (ADS)

    Clark, R. W.; Giuliani, J. L.; Terry, R.; Davis, J.; Velikovich, A. L.

    1997-11-01

    Experimental results on a 1MA pulser suggest that axial magnetic fields can stabilize z-pinch implosions and enhance the compression ratio(S. Sorokin and S. Chaikovsky, Dense Z-Pinches, AIP Conf. Proc. 299, p.83 (1993).). The present theoretical work calculates the effects of an axial magnetic field on the plasma and field profiles in an imploding z-pinch. The initial mass configuration is an annular shell of krypton. The 1-D simulation model includes: resistive diffusion (skin effect) for both the azimuthal and axial fields, ionization dynamics, and non-LTE radiation transport. Unlike the constant pulser current of self-similar models for the screw-pinch, a transmission line is used to model the circuit of a realistic ~10MA pulser. The implosion dynamics resulting from an axial field generated by a twisted return current cage will be compared with results due to an initial field from external Helmholtz coils. The dependence of the radiative performance on compression ratio, which in turn is a function of inital field strength or cage twist, will be discussed.

  16. Orientation dependent cantilever torque magnetometry in high magnetic fields and low lemperatures

    NASA Astrophysics Data System (ADS)

    Chaparala, M. V.

    1996-03-01

    The measurement of the magnetic torque τ, as a function of the orientation of the field with respect to the sample axes θ, is a very sensitive and direct method for measuring the anisotropy of magnetic thin films, high Tc superconductors, and other anisotropic systems. With traditional torque magnetometers the limitations of the available sample volume at cryogenic temperature has necessitated the use of a horizontal field, split coil magnets. While solenoid coil vertical field magnets provide much higher fields, the sample space limitations have excluded their use in these measurements. We have designed and built a rotator for the high field magnets at NHMFL that will accomodate the single crystal silicon cantilever magnetometer(M. Chaparala, O.H. Chung and M.J. Naughton, A.I.P. Conf. Proc. 273, 407 (1992).). With this setup we have extended the range of torque magnetometry to high magnetic fields (20T) and low temperatures (0.5K). The setup has an ultimate angular resolution of about a millidegree. I will summarize on the design and performance of this rotator/cantilever torque magnetometer combination and present the results of the the torque measurements on a Tl_2212 single crystal.

  17. Gas Phase Rovibrational Spectroscopy of Dmso, PART.I: when a Synchrotron Source Reveals AN Unusual Rotational Behaviour

    NASA Astrophysics Data System (ADS)

    Cuisset, Arnaud; Sadovskii, Dmitrii A.; Pirali, Olivier

    2013-06-01

    Many of us have enjoyed the spectacle of a spinning top influenced by friction: rotating rapidly about a stable stationary axis, the top loses slowly its angular momentum j (and energy), slows down gradually, and then, suddenly, its axis becomes unstable, the top wobbles, and an abrupt change of the top's position follows. In other words, the system undergoes a bifurcation. In the case of the tippe top, rotation about its lower point is stable at low values of angular momentum J and becomes unstable at large J. Something quite similar occurs in a freely rotating dimethylsulfoxyde (DMSO, (CH_3)_2SO) molecule. For the first time in such large polyatomic molecule a quantum bifurcation induced by a gyroscopic destabilization was observed. This unusual phenomenon in rotational dynamics was discovered in the rovibrational states of the bending fundamental ν_{23} band of DMSO whose high-resolution gas phase absorption spectrum was observed along with that of ν_{11} by Cuisset et al. using the exceptional properties of the AILES beamline in the Far-Infrared domain. A. Cuisset, O. Pirali, D. Sadovskii,Phys. Rev. Lett., 109,(094101), 2012. A. Cuisset, L. Nanobashvili, I. Smirnova, R. Bocquet, F. Hindle, G. Mouret, O. Pirali, P. Roy, D. Sadovskii,Chem. Phys. Lett., 492,(30),2010 J. B. Brubach et al., AIP Conf. Proc., 1214, (81), 2010.

  18. Extracting the Injection History of Solar Energetic Particles on Solar Probe Plus

    NASA Astrophysics Data System (ADS)

    Roelof, E. C.; Hill, M. E.

    2013-05-01

    Studies over the last Solar Cycle of nearly scatter-free solar energetic particle propagation during magnetically well-connected impulsive events established that the particle injection history could be extracted directly from the anisotropy histories of beam-like events (without requiring the solution of a full propagation equation). However, the limitation of observations at 1AU was that the particles back-scattered from beyond 1AU began to arrive before the maximum intensity of out-going particles, thus partially obscuring the remainder of the injection history (which usually extended well beyond the event maximum). Fortunately, as Solar Probe Plus moves inward towards its perihelion, the arrival of the back-scattered component (which still must travel inward from beyond 1 AU) will likely be delayed until well after the injection maximum, giving the ISIS/EPI-Lo & EPI-Hi instruments a much clearer diagnostic of the entire injection process. Examples of intensity histories for such events well inside 1 AU will be constructed (based on beam-like events observed at 1 AU by ACE/EPAM and SOHO/ERNE), using the functional equation directly relating the scatter-free and the back-scatter propagation (Roelof, AIP Conf. Proc., 1039, pp. 174-183, 2008).

  19. A simple model for the generation and detection of a poloidal magnetic field in laser-target interactions

    NASA Astrophysics Data System (ADS)

    Ryutov, Dmitri; Remington, Bruce

    2006-10-01

    When a linearly-polarized ultra-intense laser beam interacts with a target, it may generate not only toroidal but also poloidal non-oscillating magnetic field (D.D. Ryutov, B.A. Remington. AIP Conf. Proc., v. 827, p. 341, 2006; Astrophys. Space Sci., submitted, 2006). The poloidal field has a structure resembling the field of a group of four sunspots of alternating polarity. Its magnitude may reach the magnitude of an oscillating magnetic field in the incident wave. Effects of a pulse duration and ion expansion are discussed. Scaling laws determining this field are established. Detection of this field is feasible with side-on ion deflectometry. An optimum orientation of the probe beam is shown to form a 45-degree angle with the polarization plane. Examples of the distortion of an image of a rectangular grid are presented. It is concluded that the poloidal field can be identified even in the presence of the toroidal field of a comparable magnitude. Work performed for US DoE by UC LLNL under contract #W-7405-Eng-48.

  20. Proof-of-principle demonstration of a virtual flow meter-based transducer for gaseous helium monitoring in particle accelerator cryogenics

    SciTech Connect

    Arpaia, P.; Blanco, E.; Inglese, V.; Pezzetti, M.; Serio, L.; Girone, M.; Piccinelli, F.

    2015-07-15

    A transducer based on a virtual flow meter is proposed for monitoring helium distribution and consumption in cryogenic systems for particle accelerators. The virtual flow meter allows technical and economical constraints, preventing installation of physical instruments in all the needed measurement points, to be overcome. Virtual flow meter performance for the alternative models of Samson [ http://www.samson.de (2015)] and Sereg-Schlumberger [ http://www.slb.com/ (2015)] is compared with the standard IEC 60534-2-1 [Industrial-process control valves—Part 2-1: Flow capacity—sizing equations for fluid flow under installed conditions (2011), https://webstore.iec.ch/publication/2461], for a large temperature range, for both gaseous and liquid helium phases, and for different pressure drops. Then, the calibration function of the transducer is derived. Finally, the experimental validation for the helium gaseous state on the test station for superconducting magnets in the laboratory SM18 [Pirotte et al., AIP Conf. Proc. 1573, 187 (2014)] at CERN is reported.

  1. Particle acceleration and transport in a chaotic magnetic field

    NASA Astrophysics Data System (ADS)

    Li, X.; Li, G.; Dasgupta, B.

    2012-12-01

    Time-dependent chaotic magnetic field can arise from a simple asymmetric current wire-loop system (CWLS). Such simple CWLSs exist, for example, in solar flares. Indeed one can use an ensemble of such systems to model solar active region magnetic field [1,2]. Here we use test particle simulation to investigate particle transport and energization in such a time-dependent chaotic magnetic field, and through induction, a chaotic electric field. We first construct an ensemble of simple systems based on the estimated size and field strength of solar active region. By following the trajectories of single charged particles, we will examine how particle energy is changed. Diffusion coefficients in both real space and momentum space can be calculated as well as the average trapped time of the particles within chaotic field region. Particle energy spectrum as a function of time will be examined. [1] Dasgupta, B. and Abhay K. Ram, (2007) Chaotic magnetic fields due to asymmetric current configurations -application to cross field diffusion of particles in cosmic rays, (Presented at the 49th Annual Meeting of the DPP, APS, Abstract # BP8.00102) [2] G. Li, B. Dasgupta, G. Webb, and A. K. Ram, (2009) Particle Motion and Energization in a Chaotic Magnetic Field, AIP Conf. Proc. 1183, pp. 201-211; doi: http://dx.doi.org/10.1063/1.3266777

  2. Application of rank-ordered multifractal analysis (ROMA) to intermittent fluctuations in 3D turbulent flows, 2D MHD simulation and solar wind data

    NASA Astrophysics Data System (ADS)

    Wu, C.; Chang, T.

    2010-12-01

    A new method in describing the multifractal characteristics of intermittent events was introduced by Cheng and Wu [Chang T. and Wu C.C., Physical Rev, E77, 045401(R), 2008]. The procedure provides a natural connection between the rank-ordered spectrum and the idea of one-parameter scaling for monofractals. This technique has been demonstrated using results obtained from a 2D MHD simulation. It has also been successfully applied to in-situ solar wind observations [Chang T., Wu, C.C. and Podesta, J., AIP Conf Proc. 1039, 75, 2008], and the broadband electric field oscillations from the auroral zone [Tam, S.W.Y. et al., Physical Rev, E81, 036414, 2010]. We take the next step in this procedure. By using the ROMA spectra and the scaled probability distribution functions (PDFs), raw PDFs can be calculated, which can be compared directly with PDFs from observations or simulation results. In addition to 2D MHD simulation results and in-situ solar wind observation, we show clearly using the ROMA analysis the multifractal character of the 3D fluid simulation data obtained from the JHU turbulence database cluster at http://turbulence.pha.jhu.edu. In particular, we show the scaling of the non-symmetrical PDF for the parallel-velocity fluctuations of this 3D fluid data.

  3. Electro-optic modulation of a laser at microwave frequencies for interferometric purposes

    NASA Astrophysics Data System (ADS)

    Specht, Paul E.; Jilek, Brook A.

    2017-02-01

    A multi-point microwave interferometer (MPMI) concept was previously proposed by the authors for spatially-resolved, non-invasive tracking of a shock, reaction, or detonation front in energetic media [P. Specht et al., AIP Conf. Proc. 1793, 160010 (2017).]. The advantage of the MPMI concept over current microwave interferometry techniques is its detection of Doppler shifted microwave signals through electro-optic (EO) modulation of a laser. Since EO modulation preserves spatial variations in the Doppler shift, collecting the EO modulated laser light into a fiber array for recording with an optical heterodyne interferometer yields spatially-resolved velocity information. This work demonstrates the underlying physical principle of the MPMI diagnostic: the monitoring of a microwave signal with nanosecond temporal resolution using an optical heterodyne interferometer. For this purpose, the MPMI concept was simplified to a single-point construction using two tunable 1550 nm lasers and a 35.2 GHz microwave source. A (110) ZnTe crystal imparted the microwave frequency onto a laser, which was combined with a reference laser for determination of the microwave frequency in an optical heterodyne interferometer. A single, characteristic frequency associated with the microwave source was identified in all experiments, providing a means to monitor a microwave signal on nanosecond time scales. Lastly, areas for improving the frequency resolution of this technique are discussed, focusing on increasing the phase-modulated signal strength.

  4. Origin of the enthalpy features of water in 1.8 nm pores of MCM-41 and the large Cp increase at 210 K

    NASA Astrophysics Data System (ADS)

    Johari, G. P.

    2009-03-01

    It is shown that exothermic and endothermic features of dHm/dt observed on heating rapidly precooled and slowly precooled states of water in 1.8 nm pores of MCM-41 and the unusually large increase in the specific heat in the 210-230 K range [M. Oguni, Y. Kanke, S. Namba, and AIP Conf, Proc. 982, 34 (2008)] are inconsistent with kinetic unfreezing of a disordered solid, or glass softening. The exotherm is attributable to the melt's gradual conversion to distorted icelike structures and the endotherm to the reverse process until their fractional amounts reach a reversible equilibrium on heating. The large increase in Cp,m with T is attributed to the latent heat, similar to that seen on premelting of fine grain crystals. The available calorimetric data on freezing and melting and the pore-size dependence of the features support this interpretation. The findings also put into question a conclusion from neutron scattering studies that in 1.8 nm pores water undergoes a structural and kinetic transition at ˜225 K while remaining a liquid.

  5. Proof-of-principle demonstration of a virtual flow meter-based transducer for gaseous helium monitoring in particle accelerator cryogenics

    NASA Astrophysics Data System (ADS)

    Arpaia, P.; Blanco, E.; Girone, M.; Inglese, V.; Pezzetti, M.; Piccinelli, F.; Serio, L.

    2015-07-01

    A transducer based on a virtual flow meter is proposed for monitoring helium distribution and consumption in cryogenic systems for particle accelerators. The virtual flow meter allows technical and economical constraints, preventing installation of physical instruments in all the needed measurement points, to be overcome. Virtual flow meter performance for the alternative models of Samson [http://www.samson.de (2015)] and Sereg-Schlumberger [http://www.slb.com/ (2015)] is compared with the standard IEC 60534-2-1 [Industrial-process control valves—Part 2-1: Flow capacity—sizing equations for fluid flow under installed conditions (2011), https://webstore.iec.ch/publication/2461], for a large temperature range, for both gaseous and liquid helium phases, and for different pressure drops. Then, the calibration function of the transducer is derived. Finally, the experimental validation for the helium gaseous state on the test station for superconducting magnets in the laboratory SM18 [Pirotte et al., AIP Conf. Proc. 1573, 187 (2014)] at CERN is reported.

  6. Proof-of-principle demonstration of a virtual flow meter-based transducer for gaseous helium monitoring in particle accelerator cryogenics.

    PubMed

    Arpaia, P; Blanco, E; Girone, M; Inglese, V; Pezzetti, M; Piccinelli, F; Serio, L

    2015-07-01

    A transducer based on a virtual flow meter is proposed for monitoring helium distribution and consumption in cryogenic systems for particle accelerators. The virtual flow meter allows technical and economical constraints, preventing installation of physical instruments in all the needed measurement points, to be overcome. Virtual flow meter performance for the alternative models of Samson [ http://www.samson.de (2015)] and Sereg-Schlumberger [ http://www.slb.com/ (2015)] is compared with the standard IEC 60534-2-1 [Industrial-process control valves-Part 2-1: Flow capacity-sizing equations for fluid flow under installed conditions (2011), https://webstore.iec.ch/publication/2461], for a large temperature range, for both gaseous and liquid helium phases, and for different pressure drops. Then, the calibration function of the transducer is derived. Finally, the experimental validation for the helium gaseous state on the test station for superconducting magnets in the laboratory SM18 [Pirotte et al., AIP Conf. Proc. 1573, 187 (2014)] at CERN is reported.

  7. Beam On Target (BOT) Produces Gamma Ray Burst (GRB) Fireballs and Afterglows

    NASA Astrophysics Data System (ADS)

    Greyber, H. D.

    1997-12-01

    Unlike the myriads of ad hoc models that have been offered to explain GRB, the BOT process is simply the very common process used worldwide in accelerator laboratories to produce gamma rays. The Strong Magnetic Field (SMF) model postulates an extremely intense, highly relativistic current ring formed during the original gravitational collapse of a distant galaxy when the plasma cloud was permeated by a primordial magnetic field. GRB occur when solid matter (asteroid, white dwarf, neutron star, planet) falls rapidly through the Storage Ring beam producing a very strongly collimated electromagnetic shower, and a huge amount of matter from the target, in the form of a giant, hot, expanding plasma cloud, or ``Fireball,'' is blown off. BOT satisfies all the ``severe constraints imposed on the source of this burst --'' concluded by the CGRO team (Sommer et al, Astrophys. J. 422 L63 (1994)) for the huge intense burst GRB930131, whereas neutron star merger models are ``difficult to reconcile.'' BOT expects the lowest energy gamma photons to arrive very slightly later than higher energy photons due to the time for the shower to penetrate the target. The millisecond spikes in bursts are due to the slender filaments of current that make up the Storage Ring beam. Delayed photons can be explained by a broken target ``rock.'' See H. Greyber in the book ``Compton Gamma Ray Observatory,'' AIP Conf. Proc. 280, 569 (1993).

  8. 78 FR 16540 - AIP Series Trust and Morgan Stanley AIP GP LP; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... of the acquiring company. Section 12(d)(1)(B) of the Act prohibits a registered open-end investment... Underlying Fund to a Fund of Funds in excess of the limits in section 12(d)(1)(B) of the Act. 3. Applicants... concerns underlying sections 12(d)(1)(A) and (B), which include concerns about undue influence by a fund...

  9. The role of the interplanetary shock surface fluctuations in shaping energetic storm particle events

    NASA Astrophysics Data System (ADS)

    Lario, D.; Decker, R. B.

    2006-12-01

    Solar cycle 23 has provided us with a large variety of shocks and associated energetic particle storm (ESP) events. Statistical analysis of shocks and ESP events detected by ACE has shown a tendency for observing more quasi-perpendicular shocks; whereas the most common types of event are those that do not display any >47 keV ion intensity increase [Lario et al., 2005a; Proc. SW11, ESA SP-592, pp. 81-86]. Faster and stronger shocks have greater effects on the particle intensities at their passage by 1 AU, but the shock parameters do not determine unequivocally the characteristics of the ESP events. A few of these events show characteristics similar to those predicted by the theory of diffusive shock acceleration, although detailed analysis reveals significant inconsistencies between observations and theory [Lario et al., 2005b; Proc. 4th IGPP Conf., AIP-781, pp. 180-184]. A common type of event has irregular structure, showing multiple intensity bursts before and/or after the shock passage. We present both the observations of one of these events and the results of a test-particle, full-orbit-integration simulation of ion shock-acceleration in a corrugated shock surface [Decker, 1990; JGR 95, pp. 11993-12003]. Although meso-scale fluctuations of the shock surface or in magnetic field direction, or both, can produce similar features in shock-accelerated particle distributions, we invoke the rippled shock model in this case because the measured pre-shock field is relatively steady. These simulations allow us to reproduce not only the evolution of the ion intensities but also the observed ion anisotropies and energy spectra. Fluctuations of both the solar wind plasma where the shock travels and of the shock surface may determine the main features of those ESP events with irregular variations of intensities and angular distributions. This presentation constitutes a progress report on NASA LWS TR{&}T grant NAG5-13487.

  10. PROC LCA: A SAS Procedure for Latent Class Analysis

    ERIC Educational Resources Information Center

    Lanza, Stephanie T.; Collins, Linda M.; Lemmon, David R.; Schafer, Joseph L.

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across…

  11. Generating Matrices of C-nomial Coefficients and Their Spectra

    DTIC Science & Technology

    2010-04-20

    International Conf. Fibonacci Numbers & Applic . 2010. 14. ABSTRACT In this paper, we consider a generalization of binomial coe cients, called C{ nomial coe...combinatorial matrices, Congressus Numerantium Vol. 201 (2010), Proc. Internat. Conf. Fibonacci Numbers & Applic . – ’08, 223–236. [18] E. Kilic and P...coefficients via generating func- tion, Discrete Appl. Math. 155 (2007), 2017–2024. [24] S. Vajda, Fibonacci & Lucas numbers , and the golden section, John

  12. New Nanocrystalline Core Performance Versus Finemet(Registered) for High-power Inductors

    DTIC Science & Technology

    2008-12-01

    electric ground vehicle systems. The design and development of compact, high-power, and high- temperature inductors for a 150 kW...002 nanocrystalline core material is compared. 1. INTRODUCTION Hybrid- electric vehicles (HEV) and their supporting technological advancements have... Electr . Conf., 1258-1263. Urciuoli, D. and C. W. Tipton, 2006: Development of a 90 kW Bi-Directional DC-DC Converter for Power Dense Applications, Proc. of 21st IEEE Appl. Power Electr . Conf., 1375-1378.

  13. High Repetition Rate Electron Beam RF-Acceleration and Sub-Millimeter Wave Generation Via a Free Electron Laser.

    DTIC Science & Technology

    1987-08-14

    D.S. Furuno, N.C. Luhmann, Jr., W.J. Nunan , Haibo Cao, "Compact, High Power Millimeter Wave Sources," Proc. of Sixth Int. Conf. High Power Particle...Beams, Osaka, Japan (1986). (b) D.B. McDermott, W.J. Nunan and N.C. Luhmann, Jr., "A Prebunched 94 GHz Free Electron Laser," Proc. of the Eleventh IEEE...Int. Conf. IR and mm-Waves, Pisa, Italy (1986). (c) W.J. Nunan , D.B. McDermott and N.C. Luhmann, Jr., "A High Duty Cycle, Compact 94 GHz FEL," Bull

  14. Science on the Moon: The Wailing Wall of Space Exploration

    NASA Astrophysics Data System (ADS)

    Wilson, Thomas

    conference. However, whatever the list the issue of cooperation and binding collaboration remains. As observers of Moon and other space enterprises, we all know that a room full of 60 scientists will not agree on much of anything and there will probably be 60! pleas for more funding. People have special interests and little common sense (e.g., conflict between NSF- and NASA-funding roadmaps). Scientists are no exception. Nevertheless, CERN has done it on Earth! Can we do the same on the Moon? Some of the present generation of proposals for science from and on the Moon, plus new ones, will witness a place in space exploration's future. It is clear, however, that the world has not thought this through adequately, except for talk about an international space federation - whatever that is. An outpost on the Moon with humans permanently living there much like Antarctica on Earth may be in our future. However, such planning is our collective international responsibility and not that of special-interest investigators from individual nations - unless they intend to pay for it. [1] Mendell W. W. (1985) Lunar Bases and Space Activities of the 21st Century, Lunar and Planetary Institute, Houston. [2] Potter A. E. and Wilson T. L. (1990) Physics and Astrophysics from a Lunar Base, AIP Conf. Proc. 202, American Institute of Physics, New York. [3] Mumma M. J. and Smith H. J. (1990) Astrophysics from the Moon, AIP Conf. Proc. 207, American Institute of Physics, New York.

  15. Nano-Engineering of Active Metamaterials

    DTIC Science & Technology

    2014-10-29

    follows for silicon-organic hybrid (SOH) and plasmonic silicon-organic hybrid (PSOH) devices: For SOH devices, the following performance has been...H. Steier, Harold R. Fetterman, Pierre Berini, and Larry R. Dalton, “Active Plasmonic and Metamaterials and Devices,” Proc SPIE, 7754, 775403 1-10...Embedded Plasmonic Metal-Slotted Polymer Electro-Optic Waveguide Modulator,” Proc. 2011 Conf. on Laser and Electro-Optics, pp. 1-3 (2011). 24. H. Figi

  16. Smart Register Files for High-Performance Microprocessors

    DTIC Science & Technology

    1999-06-28

    an Intel Technology for Education 2000 grant.46 Bibliography [1] David R. Ditzel and H. R. McLellan . Register Allocation for Free: The C Machine Stack...and Matthew O’Keefe. Reducing Memory Traffic with CRegs. Proc. 27th Intl. Symp. Microarchitecture, pp. 100-104, Nov, 1994. [8] Keith D. Cooper and...Language Design and Implementation (PLDI), pp. 297-307, , 1998. [24] Keith Cooper and John Lu. Register Promotion in C Programs. Proc. ACM SIG- PLAN Conf

  17. Cross-Boundary Security Analysis

    DTIC Science & Technology

    2013-04-01

    Reps is the co-founder, along with Prof. Emeritus Tim Teitelbaum of Cornell, of a company called GrammaTech, Inc. GrammaTech, which now has about 53...2011. 6. Driscoll, E., Burton , A., and Reps, T., Checking compatibility of a producer and a consumer. In Proc. Found. of Software Engineering (FSE...by automatic instrumentation. In Proc. ACM Conf. on Computer and Communications Security (CCS), 2010. 9. Thakur, A.V., Lim, J., Lal, A., Burton , A

  18. Adaptive Estimation and Parameter Identification Using Multiple Model Estimation Algorithm

    DTIC Science & Technology

    1976-06-23

    Point Continuous Linear Smoothing ," Proc. Joint Automatic Control Conf., June 1967, pp. 249-257. [26] J. S. Meditch , "On Optimal Linear Smoothing ...Theory," Infor- mation and Control, 10, 598-615 (1967). [27] J. S. Meditch , "A Successive Approximation Procedure for Nonlinear Data Smoothing ," Proc...algorithm Kalman filter algorithms multiple model smoothing algorithm 70. ABSTRACT (Coensnia• en rever.e side if eceossuy Adidonilty by block nu.wbe

  19. Waveform-Agile Sensing: Opportunities and Challenges

    DTIC Science & Technology

    2005-03-01

    beamforming and orthogonal space - time block coding,” Proc. IEEE ICASSP, Philadelphia, April 2005. [2] S.D. Howard, A.R. Calderbank, W. Moran, H.A...and O. Solgaard, “Femtosecond direct space -to- time pulse with MEMS micromirror arrays,” Proc. IEEE/LEOS Int. Conf. Optical MEMS, pp. 18-21, Aug. 2003...0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing

  20. Bondability of Ti Adherends. III. Oxide Stability and Substrate Corrosion.

    DTIC Science & Technology

    1982-09-01

    LeGoff , in Proc. 7th Int. Vac. Congr . and 3rd Int. Conf. Solid Surf. (Vienna, 1977), p. 1789. 9 LW. Allen, H.S. Alsalim, and W.C. Wake, J. Adhes. 6...and J. Gandon, Surf. Technol. 8, 203 (1979). 8. G. Blondeau, M. Froelicher, M. Forment, and A. Hugot- LeGoff , in Proc. 7th Int. Vac. Congr. and 3rd

  1. Advanced Numerical Techniques of Performance Evaluation. Volume 1

    DTIC Science & Technology

    1990-06-01

    results blocks and stacks in free lists [Bershad et al. 19884 . If these data in an analytical model Section 6 summaiis our experiences. siicme were...diue ap s te bi a seends forance cmaagemnt astowsa sors can queue created threds locally, since balancing is achieved the elpe tmt ind foah rea n "null...Thakkar 1988] The Symmetry Multiprocessor System, Proc. 1988 Ind . Conf. on Par. Proc. (Aug. 1988). 3 [Ousterhout 1982] John K. Ousterhout. Scheduling

  2. Low altitude cloud height and methane humidity retrievals on Titan in the near-IR

    NASA Astrophysics Data System (ADS)

    Adamkovics, M.; Hayes, A.; Mitchell, J.; De Pater, I.; Young, E.

    2013-12-01

    The formation of low altitude clouds on Titan, with cloud-top altitudes below ~10km, likely occurs by a fundamentally different mechanism than for the clouds commonly observed to have cloud-tops in the upper troposphere, above ~15km [1]. Near-infrared spectroscopy of clouds has been the method of choice for determining cloud altitudes [2], however, uncertainties in aerosols scattering properties and opacities, together with limitations in laboratory measurements of gas opacities (in particular for methane), lead to uncertainties in how accurately the altitude of low clouds can be retrieved [3]. Here we revisit near-IR spectra obtained with Keck and Cassini using new laboratory methane line data in the HITRAN 2012 database [4] to address the problem of measuring the altitudes of low clouds. We discuss the role of topography in relation to the formation of low clouds and other diagnostics of conditions near the surface, such as the tropospheric methane humidity. We reanalyze measurements the tropospheric humidity variation [5] and describe observational strategies for improved diagnostics of the tropospheric humidity on Titan . Acknowledgements: Funding for this work is provided by the NSF grant AST-1008788 and NASA OPR grant NNX12AM81G. References: [1] Brown, et al. (2009) ApJ, 706, L110-L113. [2] Ádámkovics et al. (2010) Icarus, 208, 868-877. [3] Griffith et al. (2012) Icarus, 218, 975-988. [4] Rothman et al. (2013) AIP Conf. Proc., 1545, 223-231. [5] Penteado & Griffith (2010) Icarus, 206, 345-351.

  3. μSR search for loop currents in GdBCO

    NASA Astrophysics Data System (ADS)

    Songatikamas, T.; Sio, H.; Norris, R.; Browne, M. C.; Boekema, C.

    2010-03-01

    In the cuprate pseudogap phase, Varma [1] predicts loop currents above Tc. We search for magnetic fields created by such currents in GdBa2Cu3O(7-δ) (GdBCO). Using Maximum Entropy (ME) [2] we analyze zero-field (ZF) muon-spin-resonance (μSR) data [3] of GdBCO. ME-μSR applied to ZF-GdBCO data yields a frequency distribution with T-dependent signals at 0-MHz [3] and 0.3-MHz (f1) and hints of 1.4-MHz (f*) signals. To cancel systematic f1 effects, we analyze DS(t,T) ≡ S(t,T>Tc) - S(t,T'<AIP Conf Proc #1073 p260; JC Lee et al, J Appl Phys 95 (2004) 6906. [3] DW Cooke et al, PRB37 (1988) 9401. [4] J Xia et al, PRL 100 (2008) 127002

  4. Hydrodynamic instability growth of three-dimensional, “native-roughness” modulations in x-ray driven, spherical implosions at the National Ignition Facility

    SciTech Connect

    Smalyuk, V. A.; Weber, S. V.; Casey, D. T.; Clark, D. S.; Field, J. E.; Haan, S. W.; Hammel, B. A.; Hamza, A. V.; Landen, O. L.; Robey, H. F.; Weber, C. R.; Hoover, D. E.; Nikroo, A.

    2015-07-15

    Hydrodynamic instability growth experiments with three-dimensional (3-D) surface-roughness modulations were performed on plastic (CH) shell spherical implosions at the National Ignition Facility (NIF) [E. M. Campbell, R. Cauble, and B. A. Remington, AIP Conf. Proc. 429, 3 (1998)]. The initial capsule outer-surface roughness was similar to the standard specifications (“native roughness”) used in a majority of implosions on NIF. The experiments included instability growth measurements of the perturbations seeded by the thin membranes (or tents) used to hold the capsules inside the hohlraums. In addition, initial modulations included two divots used as spatial fiducials to determine the convergence in the experiments and to check the accuracy of 3D simulations in calculating growth of known initial perturbations. The instability growth measurements were performed using x-ray, through-foil radiography of one side of the imploding shell, based on time-resolved pinhole imaging. Averaging over 30 similar images significantly increases the signal-to-noise ratio, making possible a comparison with 3-D simulations. At a convergence ratio of ∼3, the measured tent and divot modulations were close to those predicted by 3-D simulations (within ∼15%–20%), while measured 3-D, broadband modulations were ∼3–4 times larger than those simulated based on the growth of the known imposed initial surface modulations. In addition, some of the measured 3-D features in x-ray radiographs did not resemble those characterized on the outer capsule surface before the experiments. One of the hypotheses to explain the results is based on the increased instability amplitudes due to modulations of the oxygen content in the bulk of the capsule. As the target assembly and handling procedures involve exposure to UV light, this can increase the uptake of the oxygen into the capsule, with irregularities in the oxygen seeding hydrodynamic instabilities. These new experimental results have

  5. Anomalous dimensionality dependence of diffusion in a rugged energy landscape: How pathological is one dimension?

    NASA Astrophysics Data System (ADS)

    Seki, Kazuhiko; Bagchi, Kaushik; Bagchi, Biman

    2016-05-01

    Diffusion in one dimensional rugged energy landscape (REL) is predicted to be pathologically different (from any higher dimension) with a much larger chance of encountering broken ergodicity [D. L. Stein and C. M. Newman, AIP Conf. Proc. 1479, 620 (2012)]. However, no quantitative study of this difference has been reported, despite the prevalence of multidimensional physical models in the literature (like a high dimensional funnel guiding protein folding/unfolding). Paradoxically, some theoretical studies of these phenomena still employ a one dimensional diffusion description for analytical tractability. We explore the dimensionality dependent diffusion on REL by carrying out an effective medium approximation based analytical calculations and compare them with the available computer simulation results. We find that at an intermediate level of ruggedness (assumed to have a Gaussian distribution), where diffusion is well-defined, the value of the effective diffusion coefficient depends on dimensionality and changes (increases) by several factors (˜5-10) in going from 1d to 2d. In contrast, the changes in subsequent transitions (like 2d to 3d and 3d to 4d and so on) are far more modest, of the order of 10-20% only. When ruggedness is given by random traps with an exponential distribution of barrier heights, the mean square displacement (MSD) is sub-diffusive (a well-known result), but the growth of MSD is described by different exponents in one and higher dimensions. The reason for such strong ruggedness induced retardation in the case of one dimensional REL is discussed. We also discuss the special limiting case of infinite dimension (d = ∞) where the effective medium approximation becomes exact and where theoretical results become simple. We discuss, for the first time, the role of spatial correlation in the landscape on diffusion of a random walker.

  6. Substellar Companions to Seven Evolved Intermediate-Mass Stars

    NASA Astrophysics Data System (ADS)

    Sato, Bun'ei; Omiya, Masashi; Harakawa, Hiroki; Izumiura, Hideyuki; Kambe, Eiji; Takeda, Yoichi; Yoshida, Michitoshi; Itoh, Yoichi; Ando, Hiroyasu; Kokubo, Eiichiro; Ida, Shigeru

    2012-12-01

    We report on the detections of substellar companions orbiting around seven evolved intermediate-mass stars from precise Doppler measurements at Okayama Astrophysical Observatory. o UMa (G4 II-III) is a giant with a mass of 3.1M', and hosts a planet with a minimum mass of m2 sini = 4.1MJ in an orbit with a period P = 1630 d and an eccentricity e = 0.13. The star also exhibits a linear velocity trend, suggesting the existence of an outer, more massive companion. 75 Cet (G3 III:) is a 2.5M⊙ giant hosting a planet of m2 sini = 3.0MJ in a 692 d orbit with e = 0.12. The star also shows a possible additional periodicity of about 200 d and 1880 d with a velocity amplitude of ˜7-10 m s-1, although these are not significant at this stage. ν Oph (K0 III) is a 3.0M⊙ giant, and has two brown-dwarf companions of m2 sini = 24MJ and 27MJ, in orbits with P = 530.3 d and 3190 d, and e = 0.126 and 0.17, respectively, which were independently announced by Quirrenbach, Reffert, and Bergmann (2011, AIP Conf. Proc. 1331, 102). The ratio of the periods is close to 1:6, suggesting that the companions are in mean motion resonance. We also independently confirmed planets around κ CrB (K0 III-IV) and HD 210702 (K1 IV), which were announced by Johnson et al. (2008, ApJ, 675, 784) and Johnson et al. (2007a, ApJ, 665, 785), respectively. All of the orbital parameters we obtained are consistent with the previous results.

  7. Anomalous dimensionality dependence of diffusion in a rugged energy landscape: How pathological is one dimension?

    PubMed

    Seki, Kazuhiko; Bagchi, Kaushik; Bagchi, Biman

    2016-05-21

    Diffusion in one dimensional rugged energy landscape (REL) is predicted to be pathologically different (from any higher dimension) with a much larger chance of encountering broken ergodicity [D. L. Stein and C. M. Newman, AIP Conf. Proc. 1479, 620 (2012)]. However, no quantitative study of this difference has been reported, despite the prevalence of multidimensional physical models in the literature (like a high dimensional funnel guiding protein folding/unfolding). Paradoxically, some theoretical studies of these phenomena still employ a one dimensional diffusion description for analytical tractability. We explore the dimensionality dependent diffusion on REL by carrying out an effective medium approximation based analytical calculations and compare them with the available computer simulation results. We find that at an intermediate level of ruggedness (assumed to have a Gaussian distribution), where diffusion is well-defined, the value of the effective diffusion coefficient depends on dimensionality and changes (increases) by several factors (∼5-10) in going from 1d to 2d. In contrast, the changes in subsequent transitions (like 2d to 3d and 3d to 4d and so on) are far more modest, of the order of 10-20% only. When ruggedness is given by random traps with an exponential distribution of barrier heights, the mean square displacement (MSD) is sub-diffusive (a well-known result), but the growth of MSD is described by different exponents in one and higher dimensions. The reason for such strong ruggedness induced retardation in the case of one dimensional REL is discussed. We also discuss the special limiting case of infinite dimension (d = ∞) where the effective medium approximation becomes exact and where theoretical results become simple. We discuss, for the first time, the role of spatial correlation in the landscape on diffusion of a random walker.

  8. Hydrodynamic instability growth of three-dimensional, "native-roughness" modulations in x-ray driven, spherical implosions at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Smalyuk, V. A.; Weber, S. V.; Casey, D. T.; Clark, D. S.; Field, J. E.; Haan, S. W.; Hammel, B. A.; Hamza, A. V.; Hoover, D. E.; Landen, O. L.; Nikroo, A.; Robey, H. F.; Weber, C. R.

    2015-07-01

    Hydrodynamic instability growth experiments with three-dimensional (3-D) surface-roughness modulations were performed on plastic (CH) shell spherical implosions at the National Ignition Facility (NIF) [E. M. Campbell, R. Cauble, and B. A. Remington, AIP Conf. Proc. 429, 3 (1998)]. The initial capsule outer-surface roughness was similar to the standard specifications ("native roughness") used in a majority of implosions on NIF. The experiments included instability growth measurements of the perturbations seeded by the thin membranes (or tents) used to hold the capsules inside the hohlraums. In addition, initial modulations included two divots used as spatial fiducials to determine the convergence in the experiments and to check the accuracy of 3D simulations in calculating growth of known initial perturbations. The instability growth measurements were performed using x-ray, through-foil radiography of one side of the imploding shell, based on time-resolved pinhole imaging. Averaging over 30 similar images significantly increases the signal-to-noise ratio, making possible a comparison with 3-D simulations. At a convergence ratio of ˜3, the measured tent and divot modulations were close to those predicted by 3-D simulations (within ˜15%-20%), while measured 3-D, broadband modulations were ˜3-4 times larger than those simulated based on the growth of the known imposed initial surface modulations. In addition, some of the measured 3-D features in x-ray radiographs did not resemble those characterized on the outer capsule surface before the experiments. One of the hypotheses to explain the results is based on the increased instability amplitudes due to modulations of the oxygen content in the bulk of the capsule. As the target assembly and handling procedures involve exposure to UV light, this can increase the uptake of the oxygen into the capsule, with irregularities in the oxygen seeding hydrodynamic instabilities. These new experimental results have prompted

  9. Plasmas as the Drivers for Science with Antimatter

    NASA Astrophysics Data System (ADS)

    Surko, Clifford M.

    2010-11-01

    Progress and future challenges in physics and technology with antimatter (positrons and antiprotons) will be described illustrating the important role played by plasma science [1]. Topics include the creation and study of antihydrogen (stable, neutral antimatter) [2,3] and the positronium molecule (e^+e^-e^+e^-) [4]; plans to study electron-positron plasmas [5]; the quest for a BEC gas of positronium atoms; positron binding to atoms and molecules [6]; the development of new types of positron beams for materials studies; and prospects for commercial positron traps and beams. Much of this progress has been driven by the development of new plasma techniques. Efficient positron accumulation is obtained using specially designed Penning-Malmberg traps with trapping and cooling provided by molecular gases. Plasmas are compressed radially using rotating electric fields. Long-term storage and cooling to cryogenic temperatures are obtained using traps in UHV environments in several-tesla magnetic fields [2,3]. A method to increase trap capacity by orders of magnitude will be described [7]. Prospects for portable antimatter traps and other exceedingly challenging projects such as a Ps-atom interferometer and an annihilation gamma ray laser will be discussed. Efforts to understand the behavior of antimatter in astrophysical settings will also be discussed. A sampling of references (by 1st author): [1] C. M. Surko, Phys. Pl. 11, 2333 ('04); [2] G. Gabrielse, Physics Today, Mar. ('10), 68; [3] G. B. Andresen, Phys. Rev. Lett. 105, 013003 ('10); [4] D. B. Cassidy, Nature 449, 195 ('07); [5] T. S. Pedersen, Fus. Sci. Tech., 50, 372 ('06); [6] G. F. Gribakin, Rev. Mod. Phys., in press ('10); [7] J. R. Danielson, AIP Conf. Proc. 1114 ('09), 199.

  10. Non-gyrotropic pressure anisotropy induced by velocity shear.

    NASA Astrophysics Data System (ADS)

    Tenerani, A.; Del Sarto, D.; Pegoraro, F.; Califano, F.

    2015-12-01

    We discuss how, in a collisionless magnetized plasma, a sheared velocity field may lead to the anisotropization of an initial Maxwellian state. By including the full pressure tensor dynamics in a fluid plasma model, we show, analytically and numerically, that a sheared velocity field makes an initial isotropic state anisotropic and non-gyrotropic [1], i.e., makes the plasma pressure tensor anisotropic also in the plane perpendicular to the magnetic field. The propagation of transverse magneto-elastic waves in the anisotropic plasma affects the process of formation of a non-gyrotropic pressure and can lead to its spatial filamentation. This plasma dynamics implies in particular that isotropic MHD equilibria cease to be equilibria in presence of a stationary sheared flow. Similarly, in the case of turbulence, where small-scale spatial inhomogeneities are naturally developed during the direct cascade, we may expect that isotropic turbulent states are not likely to exist whenever a full pressure tensor evolution is accounted for. These results may be relevant to understanding the agyrotropic pressure configurations which are well documented in solar wind measurements and possibly correlated to plasma flows (see e.g. Refs.[2,3]), and which have also been measured in Vlasov simulations of Alfvenic turbulence [4]. [1] D. Del Sarto, F. Pegoraro, F. Califano, "Pressure anisotropy and small spatial scales induced by a velocity shear", http://arxiv.org/abs/1507.04895 [2] H.F. Astudillo, E. Marsch, S. Livi, H. Rosenbauer, "TAUS measurements of non-gyrotropic distribution functions of solar wind alpha particles", AIP Conf. Proc. 328, 289 (1996). [3] A. Posner, M.W. Liemhon, T.H. Zurbuchen, "Upstream magnetospheric ion flux tube within a magnetic cloud: Wind/STICS", Geophys. Res. Lett. 30, (2003). [4] S. Servidio, F. Valentini, F. Califano, P. Veltri, "Local kinetic effects in Two-Dimensional Plasma Turbulence", Phys. Rev. Lett. 108, 045001 (2012).

  11. The PhysTec Project of APS, AIP, and AAPT

    NASA Astrophysics Data System (ADS)

    Jansen, Henri

    2002-04-01

    We will describe the development of the PhysTEC program at Oregon State University. The goal of this program is to enhance the number of secondary physics teachers and to improve the physics training of primary teachers and secondary teachers in related fields. Key elements of the plan include: (1) a seamless five-year program leading to a M.S. in science education and a B.S. in physics with a specialty in physics education, which takes advantage of our unique undergraduate physics curriculum (the Paradigms project); (2) a teacher-in-residence with joint duties in the Department of Physics and the Department of Science and Math Education; (3) inquiry-based and pedagogically-oriented lab and recitation sections in calculus-based introductory physics; (4) an inquiry-based physical science course for preservice elementary teachers; (5) outreach projects that enhance the preservice experience and support the methods and pedagogy training offered elsewhere in the curriculum.

  12. Society Membership Profile: Employment Mobility and Career Change. AIP Report.

    ERIC Educational Resources Information Center

    Porter, Beverly Fearn; Kellman, Dawn

    Information on the influence of employment mobility and career change on the flexibility of the physics labor force is provided, noting the past several decades have brought a dramatic roller coaster of changes to the physics community. Five sections are as follows: membership composition (demographics, professional self-identification, and…

  13. Technology Evaluation for an Advanced Individual Protection System (AIPS)

    DTIC Science & Technology

    1992-12-01

    from CO2 Using Electrolysis........................ 21 3.1.4.3 OG from Water Vapor Electrolysis (WVE).................. 22 3.1.4.4 OG from Plant/ Algae ...Dioxide Water (vapor) Electrolysis Plant/ Algae Bioregenerative Support System Respirat$ Hyperthermal Atomic Oxygen Generation Oxygen$ Surrogate Lungs...bioregernerative support -’ from Plant/ Algae system to generate oxygen, supply fresh food, Growth and remove CO2. - Impractical Artificial Gills Water flowing

  14. Initial Employment Report: 1992 Physics Degree Recipients. AIP Report.

    ERIC Educational Resources Information Center

    Neuschatz, Michael; Mulvey, Patrick

    Results of the 1991-92 annual survey for 1991-92 on initial employment rates for recipients of doctoral, masters, and bachelors degrees in physics and astronomy are reported. Overall, responses indicated that the job market for recent physics degree recipients remains tight. Other findings include the following: (1) among new bachelors degree…

  15. NASA EEE Parts and Advanced Interconnect Program (AIP)

    NASA Technical Reports Server (NTRS)

    Gindorf, T.; Garrison, A.

    1996-01-01

    none given From Program Objectives: I. Accelerate the readiness of new technologies through development of validation, assessment and test method/tools II. Provide NASA Projects infusion paths for emerging technologies III. Provide NASA Projects technology selection, application and validation guidelines for harware and processes IV. Disseminate quality assurance, reliability, validation, tools and availability information to the NASA community.

  16. Mastering Physics for Non-Academic Careers. AIP Report.

    ERIC Educational Resources Information Center

    Norton, Stephen D.; Hammer, Philip W.; Czujko, Roman

    A detailed analysis was conducted of all master's degree programs in physics in the United States, including those that offer a master's as their highest physics program and those that have a master's program in parallel with the Ph.D. program. Data were collected from colleges and universities with master's degree programs and through phone…

  17. The Early Careers of Physics Bachelors. AIP Report.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Stowe, Katie

    This report focuses on graduates in physics who did not earn any degrees after their bachelor's degree and who are not primarily students. The report is based on data from a sample of physics bachelors between December 1998 and the summer of 1999. About 1,200 respondents, out of a potential 2,400, supplied the information. At 5 to 8 years after…

  18. Women Physicists Speak Again. AIP Report, Number R-441

    ERIC Educational Resources Information Center

    Ivie, Rachel; Guo, Stacy

    2006-01-01

    Across the world, women in physics have much in common. In almost all countries, women are largely under represented in physics. In the majority of countries for which data was obtainable for this report from reliable statistical agencies, women earned no more than one-fifth of the PhDs in physics. Many women physicists across the world also…

  19. Graduate Student Report, 1998: First-Year Students. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Langer, Casey

    This report describes the population of newly enrolled graduate students in physics and astronomy who were at their current institutions for a year or less in fall 1997. The report contains information on student characteristics and explores the decision making process and critical transition points for entering graduate students. The report also…

  20. 77 FR 22376 - Airport Improvement Program (AIP) Grant Assurances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ...), preference shall be given to Vietnam era veterans, Persian Gulf veterans, Afghanistan-Iraq war veterans..., Afghanistan-Iraq war veterans, and small business concerns owned and controlled by disabled veterans. FAA...

  1. Bayesian Ambient Noise Inversion for Geoacoustic Uncertainty Estimation

    DTIC Science & Technology

    2012-09-30

    input to OASES to generate simulated data. (b) Mean sediment sound speed, density, and attenuation from the estimated PPD via inversion. IMPACT...AIP Conference Proc. 728, 22-31 (2004). [7] H. Schmidt, OASES version 3.1 User guide and reference manual. [8] M. Siderius, H. Song, P. Gerstoft

  2. Bayesian Ambient Noise Inversion for Geoacoustic Uncertainty Estimation

    DTIC Science & Technology

    2013-09-30

    sequential data: (a) True seabed sound speed profile input to OASES to generate simulated data vs mean model obtained via inversion. (b) Power...Harrison, “High-frequency geoacoustic inversion of ambient noise data using short arrays”, AIP Conference Proc. 728, 22-31 (2004). [7] H. Schmidt, OASES

  3. Advances in Data Acquisition System Technology for PBFA II

    DTIC Science & Technology

    1985-06-01

    on a LeCroy 6880 recorder. Bottan: residuals between least squares fit and 9igitized data. Performance Monitoring and Evaluation System (PMES) The...and W. B. Boyer, "PBFA-I Performance Monitoring and Evaluation System," in Proc. 3rd IEEE Int. Pulsed Power Conf., 1981, pp. 186-188; 6. w. B. Boyer

  4. Transactions of the Army Conference on Applied Mathematics and Computing (1st) Held at Washington, DC on 9-11 May 1983

    DTIC Science & Technology

    1984-02-01

    Information Control -m 3_- Problems in Mdnufacturing Techonology , Gaitherxurg, Maryland, USA, October 1982, pp. 41-49. W.H. Fleming and R.W. Rishal...E., Buturla E-M., "Two-Dimensional Static and Transient Simulation of Mobile Carrier Transport in a Semiconduotor", :proc. NASECODE I Conf., ~~-31

  5. Nano-Resonators for RF-Enabled Networked-Control

    DTIC Science & Technology

    2006-01-01

    Networked Control System As a further embodiment of the NCS environment we consider the application to a velocity estimation problem often... Networked Control System Co-simulation for Co-design,” Proc. American Control Conf. Denver, CO, USA, June, 2003. [12] R.H. Brown and S.C. Schneider

  6. A Displacement Pattern Matching Application in Elastic-Plastic Hybrid Stress Analysis

    DTIC Science & Technology

    1988-08-01

    the iterative solution scheme for the elastic- plastic problem is detailed. In order to simplify the following discussion, body forces are neglected...to Elasto- Plastic Problems ," in PROC. ASME CONF. ON BIEM, AMD-Vol. 11 (T. A. Cruse and F. J. Rizzo Eds.), ASME, Troy, New York, pp.47-84, 1975. 36

  7. Net-centric Controlled Distributed Stand-in-Jamming using UAVs-Transmission Losses and Range Limitations Due to Geo-localization Problem Over Turkish Geography

    DTIC Science & Technology

    2012-09-01

    networking in a general battlespace topology ,” Proc. of the IEEE International Conf. on System of Systems Engineering, 2008. [26] M. Magalhaes, T. E...57  Figure 28.  NEADS Operational Network without Jammer ..............................................58  Figure 29.  NEADS Topology ...without Jammer .................................................................59  Figure 30.  NEADS Topology without Jammer Simulation Results

  8. Power and Thermal Technologies for Air and Space-Scientific Research Program. Delivery Order 0017: Study of Microchip Power Module Materials Using Mini-Channel Heat Exchanger

    DTIC Science & Technology

    2009-12-01

    from the requirements of the contacts to be Ohmic (they contain internal resistance) and the method of gate attachment ( Carrion , 2007). At...Proc. of the Conf. for Power Electronics, Intelligent Motion and Power Quality (PCIM’07), Nuremberg (Germany), 2007. Carrion , E., Suehle, Dr. J

  9. Analytical Model of Incipient Breaching of Coastal Barriers

    DTIC Science & Technology

    2003-09-29

    Moriches Inlet has a well-documented history of opening and closing in the past century ( Czerniak , 1977; Schmeltz et al., 1982). The modern inlet was...area relations for small tidal inlets, Proc. 17th Coastal Eng. Conf., ASCE, pp. 2,517–2,533. Czerniak , M. T. (1977). Inlet interaction and stability

  10. Tracking Human Faces in Infrared Video

    DTIC Science & Technology

    2006-01-01

    June 1998. [5] M. Isard and J. MacCormick , “Bramble: A bayesian multiple-blob tracker,” in Proc. 8th Int. Conf. Com- puter Vision, 2001. [6] L. Wolff, D...Intelligence, vol. 78, pp. 101–134, 1995. [13] J. MacCormick , Probabilistic models and stochastic algorithms for visual tracking, Ph.D. thesis, Oxford

  11. Proceedings of the Annual Conference on Manual Control (15th) held March 20 - 22, 1979, Wright State University, Dayton, Ohio

    DTIC Science & Technology

    1979-11-01

    Performance in a Precognitive Tracking Task," Proc. 13th Annual Conf. on Manual Control, pp. 152-165, June 1977. (32] Repa Brian S. and Robert S. Zucker...operators that have received attention in manual control. Precognitive manual control displays differ from the pursuit and compensatory displays of the

  12. Effective Holographic Record on Thin Films of Chalcogenide Semiconductors

    DTIC Science & Technology

    2001-06-01

    Matsuda, Proc. 6 th Int. Conf. Amorphous and Liquid Semicond., Leningrad, USSR, p. 35, 1976. [16] V. Vlasov, A. Kikineshi, D. Semak , D. Chepur, Ukranian J...Phys., 22, 1199 (1977). [17] V. Vlasov, D. Semak , D. Chepur, Izvestiya Vuzov, Ser. Phys., 12, 48 (1978). [18] V. Vlasov, V. Krishenik, K. Lesik, G

  13. Robust Fixed-Structure Control

    DTIC Science & Technology

    1994-10-30

    Deterministic Foundation for Statistical Energy Analysis ," J. Sound Vibr., to appear. 1.96 D. S. Bernstein and S. P. Bhat, "Lyapunov Stability, Semistability...S. Bernstein, "Power Flow, Energy Balance, and Statistical Energy Analysis for Large Scale, Interconnected Systems," Proc. Amer. Contr. Conf., pp

  14. Numerical Studies in Computer-Aided Design

    DTIC Science & Technology

    1979-04-01

    Processors, Los Alamos, September, 1978. [2] Calahan, D. A., "Performance -)f Linear Algebra Codes on the CRAY-i," Proc. 5th SPE Conf. o, Reservoir ... Simulation , Denver, January, 1979, pp. 120-127. B. Conference Presentations [31 Buning, Pieter, "Preliminary Report on ’he Evaluation of the CRAY-I as a

  15. Low-Frequency Scattering from Heterogeneous Elastic Sea Beds

    DTIC Science & Technology

    2011-09-01

    in, Proc. 4th Internat. Conf. Underwater Acoustic Measurements: Technology and Results (UAM2011), J.S. Papadakis and L. Bjorno (Eds), pp. 1615-1622...Measurements: Technology and Results (UAM2011), J.S. Papadakis and L. Bjorno (Eds), pp. 1615-1622. 14. A.N. Ivakin (2011), “Geoacoustic modeling based on

  16. Advanced Filters and Components for Power Applications

    DTIC Science & Technology

    2006-08-31

    Passive Input Filter Design". In Proc. of the 6th National Solid-State Power Conversion Conf., pages G1-1 - G1-10, May 1979. [3] M.J. Nave. Power Line Filter Design for Switched - Mode Power Supplies . Van

  17. Understanding Thermal Equilibrium through Activities

    ERIC Educational Resources Information Center

    Pathare, Shirish; Huli, Saurabhee; Nachane, Madhura; Ladage, Savita; Pradhan, Hemachandra

    2015-01-01

    Thermal equilibrium is a basic concept in thermodynamics. In India, this concept is generally introduced at the first year of undergraduate education in physics and chemistry. In our earlier studies (Pathare and Pradhan 2011 "Proc. episteme-4 Int. Conf. to Review Research on Science Technology and Mathematics Education" pp 169-72) we…

  18. Modeling and Analysis of Intrusion Detection Integrated with Batch Rekeying for Dynamic Group Communication Systems in Mobile Ad Hoc Networks

    DTIC Science & Technology

    2010-05-01

    Diffie - Hellman Key Distribution Extended to Group Communication,” Proc. of 3rd ACM Conf. on Computer and Communications Security, New Delhi, India, Jan... Diffie -Hallman (GDH) algorithm [23] as the CKA protocol for group members to generate and distribute a new group key upon a group membership change event

  19. An Error Detection and Smoothing Algorithm for Infrared Data.

    DTIC Science & Technology

    1986-04-01

    34A Dynamic Programming Technique for Nonlinear ’R. L. Lucke, A. P. Schaum , J. C. Kershenstein, J. Michalo- Smoothing", Proc. IEEE International Conf...UNIVERSITY APPLIED PHYSICS LABORATORY LAUREL. MARYLAND REFERENCES 1R. L. Lucke, A. P. Schaum , J. C. Kershenstein, J. 7 H. Ney, "A Dynamic Programming

  20. The Effect of Microstructure on the Creep behavior of Ti-6Al-2Nb-1Ta-0.8Mo.

    DTIC Science & Technology

    1985-09-01

    8217 -. - , , .. . . .. . . .,.,, - , . . . - . . . .- . . . .. ,.. . ., . -. ,,. ,: * * ~ - -, .. . - - Page 11 ments. Borradaile and Jeal (1 9 ) state that for a comparable duplex microstructure, smaller...19. J. B. Borradaile and R. H. Jeal, "Mechanical Properties of Titanium Alloys", Titanium 󈨔, Proc. Fourth Int. Conf. on Titanium, AIME, Warrendale

  1. Integration of Advanced Statistical Analysis Tools and Geophysical Modeling

    DTIC Science & Technology

    2012-08-01

    this problem with a fingerprinting algorithm that inverts for target location and orientation while holding polarizations fixed at their library values...Cross-Domain Multitask Learning with Latent Probit Mod- els,” Proc. Int. Conf. Machine Learning (ICML), 2012 L. Beran, S.D. Billings and D. Oldenburg

  2. On a question of Brown, Douglas, and Fillmore

    NASA Astrophysics Data System (ADS)

    Kim, Jaewoong; Lee, Woo Young

    2007-12-01

    In this note we answer an old question of Brown, Douglas, and Fillmore [L. Brown, R.G. Douglas, P. Fillmore, Unitary equivalence modulo the compact operators and extensions of C*-algebras, in: Proc. Conf. Operator Theory, in: Lecture Notes in Math., vol. 345, Springer, Berlin, 1973, pp. 58-128].

  3. DYMAFLEX: DYnamic Manipulation FLight EXperiment

    DTIC Science & Technology

    2013-09-03

    Moosavian. Learning- based Modified Transpose Jacobian control of robotic manipulators. In Proc. IEEE Conf. on Advanced Intelligent Mechatronics , pages...34Path planning for minimizing base reaction of space robot and its ground experimental study," in IEEE International Conference on Mechatronics

  4. Characterization of Non-Rayleigh Acoustic Scattering by Elongated Scatterers in the Water Column and on Boundaries

    DTIC Science & Technology

    2013-01-30

    key results in the literature (#1) and advancing the field (#2 and #3): aoV^oWHI 1. Key results of Ehrenberg (1972) involving the echo statistics of... Ehrenberg (1972) "A method for extracting the fish target strength distribution from acoustic echoes," in Proc. Conf. Eng. Ocean Environ., Vol. 1

  5. Comparative Experiments on Large Vocabulary Speech Recognition

    DTIC Science & Technology

    1993-01-01

    training. But in this experiment, we also com- puted separate speaker-dependent models for the speakers with 50 -100 utterances, and each speaker...of Speech (R.ASTA-PLP), Proc. of the Second European Conf. on Speech Comm. and Tech. September, 1991. [12] Liu, F-H., Stern, R., Huang, X., Acero , A

  6. Bearing-only Cooperative Localization: Simulation and Experimental Results

    DTIC Science & Technology

    2013-01-01

    cooperative localization a group of robots exchange relative position measurements from their exteroceptive sensors (e.g., camera, laser , etc.) and their...Melkumyan, and E. Nettleton , “On the linear and nonlinear observability analysis of the SLAM problem,” in Proc. IEEE Int. Conf. Mechatronics ICM

  7. Quantifying Seagrass Light Requirements Using an Algorithm to Spatially Resolve Depth of Colonization-Conf Abstract

    EPA Science Inventory

    Depth of colonization (Zc) is a useful seagrass growth metric that describes seagrass response to light attenuation. Similarly, percent surface irradiance (% SI) at Zc is a measure of seagrass light requirements with applications in seagrass ecology and management. Methods for ...

  8. Monitoring contamination due to materials outgassing by QCM-based sensors

    NASA Astrophysics Data System (ADS)

    Dirri, Fabrizio

    2016-07-01

    ), large operative temperature range (from -80°C to 130°C), temperature stability within 0.5°C and good frequency resolution of 0.1 Hz. The instruments concept and the performance evaluation, based on tests performed on the QCM based sensors (i.e. simulating an outgassing source in space conditions), are presented in this work. References : [1] Soares et al. 2003, Proc. SPIE, 09/2000; [2] Miller 1982, Report NASA TM- 82457; [3] Tighe et al. 2009, AIP Conf. Proc. 1087, 195; [4] Wood et al. 1997, AIAA 97-0841

  9. Erratum: ``Semiempirical Two-dimensional Magnetohydrodynamic Model of the Solar Corona and Interplanetary Medium'' (ApJ, 523, 812 [1999])

    NASA Astrophysics Data System (ADS)

    Sittler, Edward C., Jr.; Guhathakurta, Madhulika

    2002-01-01

    following expressions for Teff and qeff, respectively: δTeff=(2(Told-Tnew))/ (Told+Tnew), δqeff= (2(qnew-qold))/(qnew+qold). If one compares Figure 1 in this paper with Figure 9a in our original paper, one can see that the enhanced temperatures reported in our original paper at the boundary of the polar coronal hole and equatorial regions can be largely explained by the errors displayed in Figure 1. A similar comparison can be made between Figure 2 in this paper and Figure 10a in our original paper, except here the error caused an underestimate of qeff. In Figures 3 and 4 we show revised two-dimensional maps of Teff and qeff, respectively; they should be viewed as the replacement for the corresponding figures, Figure 9a and Figure 10a, respectively, in our original paper. As can be seen from these figures, there is a lack of enhanced temperatures at the boundary of the polar coronal hole and equatorial regions and a lack of suppressed values of the heat flux at corresponding regions. The contours now vary smoothly across the boundary of the polar coronal hole, and none of the anomalies mentioned in our original paper exist now. The absence of the anomalies in the revised calculations reinforces the correctness of the model calculations and the magnetic field model used. The integrations are performed along the magnetic field, which is highly divergent at the polar coronal hole boundary (i.e., octupole term dominates near the Sun), and by properly taking into account latitudinal gradients, we obtain solutions which are free of anomalies. For completeness, we show in Figure 5 the revised two-dimensional map of the plasma beta reported in our original paper (Fig. 11a). In the original paper the plasma beta was overestimated by more than a factor of 2 in the equatorial regions near the Sun. Finally, the error reported here is also present in the papers by E. C. Sittler, Jr., & M. Guhathakurta (in AIP Conf. Proc. 471, Solar Wind 9, ed. S. Habbal [New York: AIP, 1999], 401

  10. Recent Naval Postgraduate School Publications.

    DTIC Science & Technology

    1986-09-30

    Bayesian architecture for monitoring learning process in ICAI systems IEEE Int. Conf. on Systems Man and Cybernetics, Atlanta, GA, Oct. 14-17, 1§86...architecture for monitoring learning process in ICAI systems IEEE Int. Conf. on Systems Man and Cybernetics, Atlanta, GA, Oct. 14- 17, 186. IN Proc. IEEE, p. 932...temperature fatigue of 2.25Cr-iMo steel Int. Congress on Fracture, New Delhi, India , Dec., 1984. Challenger, K D; Brucker R B; Elger, W.M’ Sorek, M J

  11. Proceedings of the Antiproton Science and Technology Workshop Held in Santa Monica, California on 6-9 October 1987

    DTIC Science & Technology

    1988-07-01

    Beams, BNL 52082 (1987). - -24-- Proceedings of the Rand Second Antiproton Conf . October 6-9, 1987, Santa Monica, CA LOW ENERGY ANTIPROTON...Energy Sources of Strangeness, (UC-Santa Cruz, 1983) AlP Conf . Proc. No. 102, Particles and Fields Subseries No. 31 (ALP, N.Y., 1983), ed. by T...0.5 10.0 00 p production . 013 .25 .015 1/oe/d~dp Acceptance (irmm-mrad) 100-200 20 Collection device pulsed target lithium lens ? fithium/plosma lem

  12. High Repetition Rate Electron Beam RF-Acceleration and Sub-Millimeter Wave Generation via a Free Electron Laser.

    DTIC Science & Technology

    1985-08-14

    the American Physical Society 29. 1180 (1984). (b) D.B. McDermott, W.J. Nunan and N.C. Luhmann. Jr.. "A High Repetition Rate. Compact Free Electron...Laser." to be published in Proc. of 1985 IEEE IEDM Meeting. (c) D.B. McDermott. W.J. Nunan and N.C. Luhmann. Jr.. "A High Repetition Rate. Compact Free...Electron Laser". to be published in Proc. of Tenth S Int. Conf. on IR and mm-Waves. tApI (d) W.3. Nunan . D.B. McDermott and N.C. Luhmann. Jr.. "A

  13. Selected Bibliography II-Diamond Surface Chemistry

    DTIC Science & Technology

    1993-09-30

    34 JNL: Surface Science REF: 1 (1964) 3-21 AUTHOR: Evans T. and James P.F. TITLE: "A Study of the Transformation of Diamond to Graphite" JNL: Proc. R... Less -ordered Carbons by X-Ray Photo-electron Spectroscopy" JNL: Trans. Faraday Soc. REF: 67 (1971) 1875 3 AUTHOR: Runciman W.A. and Carter T. TITLE...on the Diamond (111) Surface" JNL: New Diamond Sci. Technol., Proc. Int. Conf., 2nd REF: (1991) 51 69 AUTHOR: Blatter A., Boegli U., Builov L.L

  14. Blind Extraction and Security Analysis of Spread Spectrum Hidden Watermarks

    DTIC Science & Technology

    2012-04-01

    1725-1731, Oct. 2000. [6] Gkizeli, M., and Pados, D. A., "Image-adaptive spread-spectrum steganography ,’’ Proc. 38th Conf. on Information Sciences and...Signature Design for Spread-Spectrum Steganography ," IEEE Transactions on Image Processing, vol. 16, no.2, pp.391-405, Feb. 2007. [9] Wei, L., Pados, D...A., Batalama, S. N., and Medley, M. J., ‘‘Sum-SINR/sum-capacity optimal multisignature spread-spectrum steganography ,’’ in Proc. SPIE Mobile

  15. Radio Implementation of a Testbed For Cognitive Radio Source Localization Using USRPS and GNU Radio

    DTIC Science & Technology

    2014-09-01

    pp. 116–130, 2009. [4] R.A. Rashid , M.A. Sarijari, N. Fisal, S.K.S. Yusof and N.H. Mahalin, “Spectrum sensing measurement using GNU Radio and...USRP software radio platform,” in Proc. 7th Int. Conf. Wireless and Mobile Commun., Luxembourg, 2011. [5] R.A. Rashid , M.A. Sarijari, N. Fisal...Sarijari, A. Marwanto, N. Fisal, S.K.S. Yusof and R.A Rashid , “Energy detection sensing based on GNU Radio and USRP: An analysis study,” in Proc

  16. Challenges in proton radioactivity studies - new emitters in the rare earth region.

    NASA Astrophysics Data System (ADS)

    Grzywacz, Robert

    2004-10-01

    Proton emitter studies offer a sensitive probe of the wave function composition for nuclei beyond the proton drip-line. In particular, the experiments on proton radioactivities in the rare earth region are allowing us to study the evolution of proton-emitting states as a function of changing deformation, from nearly spherical (e.g.^150Lu [1] or ^145Tm [2]) to strongly deformed (e.g. ^131Eu [3], ^135Tb [4] or ^141Ho [5]) shapes. The link between the measured observables (decay lifetimes and energies) and structure of the nuclei is provided by recently developed theories, which are able to model the proton tunneling process through the three dimensional potential barrier, see refs [6-8]. Very high detection efficiency and high sensitivity enable experiments at extremely low production cross sections, e.g. at the nanobarn level for the observation of ^135Tb in a (p6n) fusion-evaporation reaction channel [4]. Recent discoveries of proton radioactive nuclei will be reported. The experimental challenges will be illustrated with the example of the identification of new odd-odd emitter ^144Tm at the Recoil Mass Spectrometer [9] of Oak Ridge National Laboratory. The ^144Tm events were found in a weak ( 10 nb) p5n channel of the fusion reaction of ^58Ni beam at 340 MeV on a ^92Mo target. The observed decay energy of about 1.8 MeV and the half-life of the order of 1 μs suggest proton emission from the πh_11/2 orbital dominating the π-ν wave function. The detection of this very short proton emitter was made possible by use of a double-sided silicon strip detector connected to a fast data acquisition system [10] based on Digital Signal Processing. [1] P.G. Sellin et al., Phys. Rev. C47, 1933 (1993). [2] M. Karny et al., Phys. Rev. Lett. 90 , 012502 (2003). [3] A.A. Sonzogni et al., Phys. Rev. Lett. 83 , 1116 (1999). [4] P.J. Woods et al., Phys. Rev. C69 , 051302(R) (2004). [5] K. Rykaczewski, K. P. et al., in Proc. of Int. Conf. on Nuclear Structure ``Mapping the Triangle

  17. Experimental results of radiation-driven, layered deuterium-tritium implosions with adiabat-shaped drives at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Smalyuk, V. A.; Robey, H. F.; Döppner, T.; Casey, D. T.; Clark, D. S.; Jones, O. S.; Milovich, J. L.; Peterson, J. L.; Bachmann, B.; Baker, K. L.; Benedetti, L. R.; Berzak Hopkins, L. F.; Bionta, R.; Bond, E.; Bradley, D. K.; Callahan, D. A.; Celliers, P. M.; Cerjan, C.; Chen, K.-C.; Goyon, C.; Grim, G.; Dixit, S. N.; Eckart, M. J.; Edwards, M. J.; Farrell, M.; Fittinghoff, D. N.; Frenje, J. A.; Gatu-Johnson, M.; Gharibyan, N.; Haan, S. W.; Hamza, A. V.; Hartouni, E.; Hatarik, R.; Havre, M.; Hohenberger, M.; Hoover, D.; Hurricane, O. A.; Izumi, N.; Jancaitis, K. S.; Khan, S. F.; Knauer, J. P.; Kroll, J. J.; Kyrala, G.; Lafortune, K. N.; Landen, O. L.; Ma, T.; MacGowan, B. J.; MacPhee, A. G.; Mauldin, M.; Merrill, F. E.; Moore, A. S.; Nagel, S.; Nikroo, A.; Pak, A.; Patel, P. K.; Ralph, J. E.; Sayre, D. B.; Shaughnessy, D.; Spears, B. K.; Tommasini, R.; Turnbull, D. P.; Velikovich, A. L.; Volegov, P. L.; Weber, C. R.; Widmayer, C. C.; Yeamans, C.

    2016-10-01

    Radiation-driven, layered deuterium-tritium (DT) implosions were carried out using 3-shock and 4-shock "adiabat-shaped" drives and plastic ablators on the National Ignition Facility (NIF) [E. M. Campbell et al., AIP Conf. Proc. 429, 3 (1998)]. The purpose of these shots was to gain further understanding on the relative performance of the low-foot implosions of the National Ignition Campaign [M. J. Edwards et al., Phys. Plasmas 20, 070501 (2013)] versus the subsequent high-foot implosions [T. Döppner et al., Phys. Rev. Lett. 115, 055001 (2015)]. The neutron yield performance in the experiment with the 4-shock adiabat-shaped drive was improved by factors ˜3 to ˜10, compared to five companion low-foot shots despite large low-mode asymmetries of DT fuel, while measured compression was similar to its low-foot companions. This indicated that the dominant degradation source for low-foot implosions was ablation-front instability growth, since adiabat shaping significantly stabilized this growth. For the experiment with the low-power 3-shock adiabat-shaped drive, the DT fuel compression was significantly increased, by ˜25% to ˜36%, compared to its companion high-foot implosions. The neutron yield increased by ˜20%, lower than the increase of ˜50% estimated from one-dimensional scaling, suggesting the importance of residual instabilities and asymmetries. For the experiment with the high-power, 3-shock adiabat-shaped drive, the DT fuel compression was slightly increased by ˜14% compared to its companion high-foot experiments. However, the compression was reduced compared to the lower-power 3-shock adiabat-shaped drive, correlated with the increase of hot electrons that hypothetically can be responsible for reduced compression in high-power adiabat-shaped experiments as well as in high-foot experiments. The total neutron yield in the high-power 3-shock adiabat-shaped shot N150416 was 8.5 × 1015 ± 0.2 × 1015, with the fuel areal density of 0.90 ± 0.07 g/cm2

  18. Wave theories of non-laminar charged particle beams: from quantum to thermal regime

    NASA Astrophysics Data System (ADS)

    Fedele, Renato; Tanjia, Fatema; Jovanović, Dusan; de Nicola, Sergio; Ronsivalle, Concetta; Ronsivalle

    2014-04-01

    The standard classical description of non-laminar charged particle beams in paraxial approximation is extended to the context of two wave theories. The first theory that we discuss (Fedele R. and Shukla, P. K. 1992 Phys. Rev. A 45, 4045. Tanjia, F. et al. 2011 Proceedings of the 38th EPS Conference on Plasma Physics, Vol. 35G. Strasbourg, France: European Physical Society) is based on the Thermal Wave Model (TWM) (Fedele, R. and Miele, G. 1991 Nuovo Cim. D 13, 1527.) that interprets the paraxial thermal spreading of beam particles as the analog of quantum diffraction. The other theory is based on a recently developed model (Fedele, R. et al. 2012a Phys. Plasmas 19, 102106; Fedele, R. et al. 2012b AIP Conf. Proc. 1421, 212), hereafter called Quantum Wave Model (QWM), that takes into account the individual quantum nature of single beam particle (uncertainty principle and spin) and provides collective description of beam transport in the presence of quantum paraxial diffraction. Both in quantum and quantum-like regimes, the beam transport is governed by a 2D non-local Schrödinger equation, with self-interaction coming from the nonlinear charge- and current-densities. An envelope equation of the Ermakov-Pinney type, which includes collective effects, is derived for both TWM and QWM regimes. In TWM, such description recovers the well-known Sacherer's equation (Sacherer, F. J. 1971 IEEE Trans. Nucl. Sci. NS-18, 1105). Conversely, in the quantum regime and in Hartree's mean field approximation, one recovers the evolution equation for a single-particle spot size, i.e. for a single quantum ray spot in the transverse plane (Compton regime). We demonstrate that such quantum evolution equation contains the same information as the evolution equation for the beam spot size that describes the beam as a whole. This is done heuristically by defining the lowest QWM state accessible by a system of non-overlapping fermions. The latter are associated with temperature values that are

  19. Energetic Atomic Oxygen in the Region of the Terrestrial Exobase

    NASA Astrophysics Data System (ADS)

    Shizgal, B.; Sospedra-Alfonso, R.

    2012-12-01

    nonthermal and thermal oxygen with distribution functions, f, and F, respectively. The Boltzmann equation for f includes the source term from dissociative recombination as well as self-collisions requiring the nonlinear Boltzmann collision operator [3]. We also include cross collisions between the two species and thus anticipate a departure from Maxwellian for F, quantified with a Boltzmann equation. With this model, we are able to investigate the influence that the nonthermal oxygen may have on the thermal population of atomic oxygen. This research is supported by the Canadian Space Agency. REFERENCES [1] V. I. Shematovich, V. V. Bisikalo and J. C. Gerard, textit{J. Geophys. Res.} textbf{99}, 217-228 (1994) [2] B. Shizgal, R. Sospedra-Alfonso and A. Yau, Geophys. Res. Abstracts 14 EGU2012-6128-2, (2012). [3] R. Sospedra-Alfonso and B. Shizgal, AIP Conf. Proc. (in press).

  20. THz and Ft-Ir Study of 18-O Isotopologues of Sulfur Dioxide: 32S16O18O and 32S18O_2

    NASA Astrophysics Data System (ADS)

    Margulès, L.; Motiyenko, R. A.; Demaison, J.; Perrin, Agnes; Kwabia Tchana, F.; Manceron, Laurent

    2016-06-01

    Sulfur dioxide is a molecule that have a great interest in different domains: for atmospheric and planetology chemistry, it is also ubiquitous and abundant in interstellar medium. If the 16O species were extensively studied, this is not the case of the 18O isotopologues. The aim of this study is first to complete the rotational spectra of the ground state with these new measurements up to 1.5 THz, previous measurements are up to 1050 GHz for the 32S16O18O species, and 145 GHz concerning the 32S18O_2 species. The second part is making a global fit of the rotational and vibrational transitions for the excited vibrational states. For the v_2 band, we will complete the recent I.R. analysis. About the triad (v_1, 2v_2, v_3): 32S18O_2 species was studied, but not the 32S16O18O one. and 145 GHz concerning the 32S18O_2 species. The second part is making a global fit of the rotational and vibrational transitions for the excited vibrational states. For the v_2 band, we will complete the recent I.R. analysis. About the triad (v_1, 2v_2, v_3): 32S18O_2 species was studied, but not the 32S16O18O one. The FT-IR spectra were recorded on the AILES Beamline at Synchrotron SOLEIL using the Synchrotron light source, coupled to the Bruker IFS125HR Fourier transform spectrometer. The THz spectra were obtained from 150 to 1500 GHz using the Lille's solid state spectrometer. The analysis is in progress, the latest results will be presented. Support from the French Laboratoire d'Excellence CaPPA (Chemical and Physical Properties of the Atmosphere) through contract ANR-10-LABX-0005 of the Programme d'Investissements d'Avenir is acknowledged Belov, S. P.; et al., 1998, J. Mol. Spectrosc. 191, 17 Lindermayer, J.; et al., 1985, J. Mol. Spectrosc. 110, 357 Gueye, F.; et al. Mol. Phys. in press Ulenikov, O. N.; et al., 2015, JQSRT 166, 13 Brubach, J.; et al., 2010, AIP Conf. Proc. 1214, 81 Zakharenko, O.; et al., 2015, J. Mol. Spectrosc. 317, 41

  1. In Situ Chemical Composition Measurements of Planetary Surfaces with a Laser Ablation Mass Spectrometer

    NASA Astrophysics Data System (ADS)

    Brigitte Neuland, Maike; Riedo, Andreas; Meyer, Stefan; Mezger, Klaus; Tulej, Marek; Wurz, Peter

    2013-04-01

    The knowledge of the chemical composition of moons, comets, asteroids or other planetary bodies is of particular importance for the investigation of the origin and evolution of the Solar System. For cosmochemistry, the elemental and isotopic composition of the surface material is essential information to investigate origin, differentiation and evolution processes of the body and therefore the history of our Solar System [1]. We show that the use of laser-based mass spectrometers is essential in such research because of their high sensitivity in the ppm range and their capability for quantitative elemental and isotopic analysis. A miniaturised Laser Ablation Time-of-Flight Mass Spectrometer (LMS) was developed in our group to study the elemental composition of solid samples [2]. The instrument's small size and light weight make it suitable for an application on a space mission to determine the elemental composition of a planetary surface for example [3]. Meteorites offer the excellent possibility to study extraterrestrial material in the laboratory. To demonstrate the sensitivity and functionality of the LMS instrument, a sample of the Allende meteorite has been investigated with a high spatial resolution. The LMS measurements allowed investigations of the elemental abundances in the Allende meteorite and detailed studies of the mineralogy and volatility [4]. These approaches can be of considerable interest for in situ investigation of grains and inhomogeneous materials with high sensitivity on a planetary surface. [1] Wurz, P., Whitby, J., Managadze, G., 2009, Laser Mass Spectrometry in Planetary Science, AIP Conf. Proc. CP1144, 70-75. [2] Tulej, M., Riedo, A., Iakovleva, M., Wurz, P., 2012, Int. J. Spec., On Applicability of a Miniaturized Laser Ablation Time of Flight Mass Spectrometer for Trace Element Measurements, article ID 234949. [3] Riedo, A., Bieler, A., Neuland, M., Tulej, M., Wurz, P., 2012, Performance evaluation of a miniature laser ablation time

  2. Noncommutative complex Grosse-Wulkenhaar model

    SciTech Connect

    Hounkonnou, Mahouton Norbert; Samary, Dine Ousmane

    2008-11-18

    This paper stands for an application of the noncommutative (NC) Noether theorem, given in our previous work [AIP Proc 956(2007) 55-60], for the NC complex Grosse-Wulkenhaar model. It provides with an extension of a recent work [Physics Letters B 653(2007) 343-345]. The local conservation of energy-momentum tensors (EMTs) is recovered using improvement procedures based on Moyal algebraic techniques. Broken dilatation symmetry is discussed. NC gauge currents are also explicitly computed.

  3. Recent Naval Postgraduate School Publications.

    DTIC Science & Technology

    1980-04-01

    lr e l;near pr~grams Large Scale Opt sization Session, Oper. Res. Soc. of America/Inst. Manage. Sci., Atlanta, Ga ., Nov., 1977. IN Proc. Bradley, G H...solvers with Gear’s method SIAM Mtg., Atlanta, Ga ., Oct. 20, 1976. Franke, R H Comparison of some local methods for interpolation of scattered data...Louis I R Organizational inquiry from the outside or inside: Two epistemological perspectives Academy of Manage. Conf., Atlanta, Ga ., Aug., 1979

  4. Scalable Heterogeneous Multiagent Teams Through Learning Policy Geometry

    DTIC Science & Technology

    2011-10-01

    networks based on each network’s position on a virtual field. For example, the positions are like the positions of soccer players on a soccer team, with...Theory and Practice IX (GPTP-2011). Springer . Littman, M. L. (1994). Markov games as a framework for multi-agent reinforcement learning. In Machine...2001). Scaling reinforcement learning toward RoboCup soccer . In Proc. 18th International Conf. on Machine Learning, 537–544. Morgan Kaufmann, San Francisco, CA. 6

  5. PROUST: Knowledge-Based Program Understanding.

    DTIC Science & Technology

    1983-08-01

    undeniably yes. If anything, PROUST is the minimum that is required! The basis for this conclusion is twofold: 1. In Artificial Intelligence research...Role of Plans in Intellegent Teaching Systems. In Brown, J. S. and Sleeman, D. (editors), Intellegent Tutoring Systems. New York. 1981. [8] Goldstein, I...95, 1978. (12] Rich, C. A Formal Representation for Plans in the Programmer’s Apprentice. In Proc. of the Seventh Int. Joint Conf. on Artificial

  6. Algebraic Information Theory and Stochastic Resonance for Binary-Input Binary-Output Channels

    DTIC Science & Technology

    2012-03-01

    invertible channel matrices. In Proc. 44th Annual Conf. on Information Sciences and Systems, CISS 2010, Princeton, NJ, USA, March 2010. [4] J. Hopfield ...Neural networks and physical systems with emergent collective computational abilities. Proceedings of the National Academy of Sciences of the USA, 79...2554–2558, April 1982. [5] Bart Kosko and Sanya Mitiam. Stochastic resonance in noisy threshold neurons. Neural Networks , 16:755–761, 2003. [6] Bart

  7. A Formal Method for Developing Provably Correct Fault-Tolerant Systems Using Partial Refinement and Composition

    DTIC Science & Technology

    2009-01-01

    which is defined in Table 5. Verify the ASW Properties. The property checker Salsa [8] easily verifies that the specification of the ASW’s normal behavior... Salsa to check the fault-tolerant specification FT for all properties listed in Table 4. All but P2 were shown to be invariants. Thus the required...Conf., 2000. 8. R. Bharadwaj and S. Sims. Salsa : Combining constraint solvers with BDDs for automatic invariant checking. In Proc. Tools and Algorithms

  8. A Formal Method for Developing Provably Correct Fault-Tolerant Systems Using Partial Refinement and Composition

    DTIC Science & Technology

    2009-01-01

    constructs the state invariant H1, which is defined in Table 5. Verify the ASW Properties. The property checker Salsa [8] easily verifies that the...as auxiliary invariants, we used Salsa to check the fault-tolerant specification FT for all properties listed in Table 4. All but P2 were shown to be...Proc. 19th Digital Avionics Sys. Conf., 2000. 8. R. Bharadwaj and S. Sims. Salsa : Combining constraint solvers with BDDs for automatic invariant

  9. A Novel Technique for Broadband Singular Value Decomposition

    DTIC Science & Technology

    2007-11-02

    SVD) is a very (MIMO) communication channels and the design of filter important tool for narrowband adaptive sensor array banks for optimal data...subspaces was quantified [3] P P Vaidyanathan, " Multirate Systems and Filterbanks", using a measure of the form a = a, /o•a where Prentice Hall (1993... multirate adaptive lossless FIR filters ", Proc IEEE Conf. The value of a as a function of SNR is plotted in figure 2. ICASSP (1995) pp. 14 60 -63 . Each

  10. Toward a Computational Theory of Early Visual Processing in Reading.

    DTIC Science & Technology

    1980-09-01

    nia) be supposed to be de efficient extraction of nicaning from iniaged text. Gi~cn the nature of written language, particularly English , a presunably...ricrslanding: Siwdies in cogniive sciencecds. iBobrow I). and Collins A.. Academic Press, 1975. Nelson The Nelson l)enn) Ieading tesi , I oughton...Inference on English ," Proc. lw. J. Conf Arlificial Intelligence 3 (1973), 255-261. Smilh F. "Familiarity or configuration vs. discriminability of

  11. Screen Fingerprints as a Novel Modality for Active Authentication

    DTIC Science & Technology

    2014-03-01

    have been the target of research for much longer time (33 years for keystroke dynamics [6] and 9 years for mouse dynamics [9]) and the performance of...Rajkumar Janakiraman. Are digraphs good for free- text keystroke dynamics ? In Proc. IEEE Conf. on Comput. Vision and Pattern Recognition (CVPR), pages...such as voice, expression, keystroke , etc., are unique to an individual, biometric analysis offers a reliable and natural solution to the problem

  12. Cooperative Control of Multiple Unmanned Autonomous Vehicles

    DTIC Science & Technology

    2005-06-03

    Intelligent Munitions", Proceedings of the WSEAS conference, Skiathos, Greece, September, 2002 [Guo 2002] Guo, W., K. Nygard, H. Qiao and A. Kamel (2002...the WSEAS conference, Skiathos, Greece, September, 2002 [Guo 2002] Guo, W., K. Nygard, H. Qiao and A. Kamel (2002). Multiple Task Allocation Problems...fuzzy reasoning trees. The main broc. oflth on for MtelCont onition,Proc. of the Second WSEAS Int. Conf. on Simulation, intent of this exercise was to

  13. Stability of Low Embankments on Soft Clay. Part 3. Centrifuge Tests and Numerical Analysis.

    DTIC Science & Technology

    1984-11-01

    findings of these two workers and others (notably Naylor, 1975), Zytynski(1976) developed CRISTINA (Critical State Numerical Algorithm). Basset et al (1981...Preliminary tests, October 1981 - March 1982 - Report to the Department of Environment, University of Cambridge. Magnan, J.P., Humbert , P., Belkeziz, A. and...strain Models, Proc. IV Int. Conf. on Num. Met. in Geomechanics, Edmonton, Canada, June 1982, pp.327-336. Magnan, J.P., Humbert , P. and Mouratidis, A

  14. Quantum State Tomography of a Fiber-Based Source of Polarization-Entangled Photon Pairs

    DTIC Science & Technology

    2007-12-20

    Quantenmechanik,” Naturwissenschaften 23, 807−812; 823−828; 844−849 (1935). 2. R. P. Feynman , R. B. Leighton, R. B. and M. L. Sands, The Feynman Lectures on... Physics , Vol. 3 (Addison-Wesley, Massachusetts, 1965). 3. C. H. Bennett and G. Brassard, in Proc. IEEE Intl. Conf. on Computers, Systems and Signal...to the advantages already discussed, the gain and dispersion of microstructure fiber can be controlled through design of the fiber’s physical

  15. Acoustic Fluidization of Crushed Rock Behind the Shock Front by Damage-Induced Secondary Seismic Radiation

    DTIC Science & Technology

    2000-09-01

    Melosh [1979] to explain long-run-out landslides, the fluid morphology of extraterrestrial impact craters , and the low coefficient of effective friction...and the fluid-like morphology of large extraterrestrial impact craters . Melosh [1996] has recently proposed acoustic fluidization as the mechanism...fluidization and the scale dependence of impact crater morphology, Proc. 13th Lunar and Planet. Sci. Conf, J. Geophys. Res., 88, supplement, A830- A834, 1983

  16. Coastal Storm Surge Analysis: Computational System, Report 2: Intermediate Submission No. 1.2

    DTIC Science & Technology

    2011-03-01

    Stillwell Renaissance Computing Institute 100 Europa Drive, Suite 540 Chapel Hill, NC 27517 Hugh Roberts, John Atkinson, Shan Zou ARCADIS 4999...finite element model. Proc., XIII Conf. on Computational Methods in Water Resources, Vol. II, L. Bentley, J. Sykes, C. Brebbia, W. Gray, and G. Pinder...PERFORMING ORGANIZATION REPORT NUMBER Renaissance Computing Institute 100 Europa Drive, Suite 540, Chapel Hill, NC 27517; ARCADIS 4999 Pearl East

  17. Real-Time Head Pose Estimation Using a WEBCAM: Monocular Adaptive View-Based Appearance Model

    DTIC Science & Technology

    2008-12-01

    Huang (2006). Graph embedded analysis for head pose estimation. In Proc. IEEE Intl. Conf. Automatic Face and Gesture Recognition , pp. 3–8. Fu, Y. and T...of human- computer and human-robot interaction. Possible appli- cations include novel computer input devices (Fu and Huang, 2007), head gesture ... recognition , driver fatigue recognition systems (Baker et al., 2004), attention aware- ness for intelligent tutoring systems, and social interac- tion

  18. Theory and Algorithms for Global/Local Design Optimization

    DTIC Science & Technology

    2005-09-29

    Sioson, C. Vasquez -Robinet, M. Shukla, D. Kumar, M. Ellis, L. S. Heath, N. Ramakrishnan, B. Chevone, L. T. Watson, L. vanZyl, U. Egertsdotter, R. R...process for eukaryotic cell cycle models with a modeling support environment", in Proc. 2003 Winter Simulation Conf., S. Chick, P. J. Sanchez , D. Ferrin...Watkinson, C. Vasquez -Robinet, M. Ellis, M. Shukla, D. Kumar, N. Ramakrishnan, L. S. Heath, R. Grene, B. I. Chevone, K. Kafadar, and L. T. Watson

  19. Electron Emission and Ion Desorption Spectroscopy of Clean and Oxidized Ti(0001).

    DTIC Science & Technology

    1984-03-30

    recombination; oxidation; photoemisslon; resonant recombination; transition metals; titanium; titanium dioxide . 20. ASSTIR ACT (Ceetfimao -OSI0 0..a it...Phys. Rev. Lett. 51, 211 (T983). 46. F. Combet-Farnoux and M. Lamoureux, in: VUV Radiation Physics, Proc. 4th Int. Conf., Eds., E.E. Koch et al...nooeeery WMd ldea, 4W block hmber) Oxidation; photoemission; direct recombination; titanium; titanium dioxide . 20. APTAT(Continuae o reverse siei nI ecessar

  20. Evaluation of Commercial and Field-Expedient Baited Traps for House Flies, Musca domestica L. (Diptera: Muscidae)

    DTIC Science & Technology

    2009-01-09

    Vector Ecology 34 (1): 99-103. 2009. Keyword Index : House fly, Musca domestica, trapping. INTRODUCTION Traps have been a mainstay of house fly (Musca...attract synanthropic flies. Proc. Pap. 46th Ann. Conf. Calif. Mosq. Vector Contr. Assoc. pp. 70-73. Pickens, L. G. and R. W. Miller. 1987. Techniques...1139: 279- 284. SAS Institute. 1992. SAS users guide: statistics. SAS Institute, Cary, NC. Warner, W. B. 1991. Attractant composition for synanthropic

  1. Species Profiles. Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (Gulf of Mexico). WHITE SHRIMP.

    DTIC Science & Technology

    1984-09-01

    74 still made up and Fischer 1167). Although spawn- 27; of the total U.S. gulf shrimp pro- ing usually peaks in June or July, duction. length...by Gunter (1956). ’iddle- principal gears until the otter trawl " ditch et al. (1980) reported that a was introduced in 1917 (Gunter and Vibrio ...Temple, R.F., and C.C. Fischer . 1967. in San Antonio 3ay, Texas. Proc. Seasonal distribution and relative Annu. Conf. Southeast. Assoc. Fish

  2. Using Invariants to Optimize Formal Specifications Before Code Synthesis

    DTIC Science & Technology

    2004-01-01

    Quine - McCluskey method [33, 25]. Later developments extended simplification over first-order theories with interpreted sym- bols: Loveland and Shostak...editors, Proc. 5th Conf. on Automated Deduction (CADE), volume 87 of LNCS, pages 97–109, Les Arcs, France, 1980. Springer- Verlag. [25] E. J. McCluskey ...states in incompletely specified sequential switching func- tions. IRE Trans. on Electronic Computers, EC-8:356–367, Sept. 1959. [33] W. V. Quine . The

  3. State-of-the-Art for Assessing Earthquake Hazards in the United States. Report 25. Parameters for Specifying Intensity-Related Earthquake Ground Motions.

    DTIC Science & Technology

    1987-09-01

    adjacent to causative faults. 16 0) (I) go gal w) LLcc10 Wc, LL. off l UFO tb~~ mm c IL I.-. ujco~ C1 t 7- LWLL wi0 0 0 WU.4 zz zw4 WuE S< amAl Ito 1 NEAR...and Sponheuer, W. 1969. Scale of Seismic Intensity: Proc. Fourth World Conf. on Earthquake Engineering, Santiago, Chile . Murphy, J. R., and O’Brien, L

  4. Non-Destructive Measurement Methods (Neutron-, X-ray Radiography, Vibration Diagnostics and Ultrasound) in the Inspection of Helicopter Rotor Blades

    DTIC Science & Technology

    2005-04-01

    the radiography gauging. In addition to the Statistical Energy Analysis (SEA) measurement a small exciter table (BK4810) and impedance head (BK 8000... Statistical Energy Analysis ; 7th Conf. on Vehicle System Dynamics, Identification and Anomalies (VSDIA2000), 6-8 Nov. 2000 Budapest, Proc. pp. 491-493... Energy Analysis (SEA) and Ultrasound Test. (UT) were concurrently applied. These methods collect accessory information on the objects under inspection

  5. Development of Methods for Computer-Assisted Interpretations of Digital Mammograms for Early Breast Cancer Detection.

    DTIC Science & Technology

    1996-03-01

    A computer analysis of mammographic microcalcifications: Global approach. Proc. IEEE 5th International Conf. on Pattern Recognition : 624-631, 1980...on the statistical measures of textural features. They tested their algorithm on 7 patient cases. A similar approach using texture analysis and...obtaining a radiograph in digital format. Recent work, though, shows a promising future. Magnin et al. (38) and Caldwell (39) used texture analysis to

  6. A Network Thermodynamic Framework for the Analysis and Control Design of Large-Scale Dynamical Systems

    DTIC Science & Technology

    2006-03-31

    control for operating room hypnosis and intefisive care unit sedation. 1.3. Goals of this Report The main goal of this report is to summarize the...significant hysteresis in the actuator response. Specifically, smart distributed actuators such as shape memory alloys, magnetostrictives, electrorheolog- ical...and J. M. Bailey, "Nonlinear adaptive control for inten- sive. care unit sedation and operating room hypnosis ," in Proc. Amer. Contr. Conf., pp. 1808

  7. Recent Naval Postgraduate School Publications

    DTIC Science & Technology

    1988-09-30

    National Computer Conference, Chicago, Ill., July 18, 1985. Sivasankaran; Bui, T A rule-based Bayesian architecture for monitoring learning process in ICAI ...Bayesian architecture for monitoring learning process in ICAI systems IEEE Int. Conf. on Systems Man and Cybernetics, Atlanta, GA, Oct. 14-17 186. IN Proc...Bangalore, India , pp. 471-484, 1988. Platzer, M F; Boelcs, Ai Fransson T H Numerical investigation of unsteady compressible flow through nozzles and

  8. Development of Analysis Tools for Certification of Flight Control Laws

    DTIC Science & Technology

    2009-03-31

    In Proc. Conf. on Decision and Control, pages 881-886, Bahamas, 2004. [7] G. Chesi, A. Garulli, A. Tesi , and A. Vicino. LMI-based computation of...Minneapolis, MN, 2006, pp. 117-122. [10] G. Chesi, A. Garulli, A. Tesi . and A. Vicino, "LMI-based computation of optimal quadratic Lyapunov functions...Convex Optimization. Cambridge Univ. Press. Chesi, G., A. Garulli, A. Tesi and A. Vicino (2005). LMI-based computation of optimal quadratic Lyapunov

  9. Linear Stimulus-Invariant Processing and Spectrotemporal Reverse Correlation in Primary Auditory Cortex

    DTIC Science & Technology

    2003-01-01

    mechanics of STRF measurement with any given stimulus, thus providing a language with which apparently disparate methods can be discussed. We focus in...Cybernetics, 38:235–248. Atlas, L. and Shamma, S. (2003). Joint acoustic and modulation frequency. EURASIP Journal of Appllied Signal Processing, 2003(7):668...88:416–422. Kleinschmidt, M. and Gelbart, D. (2002). Improving word accuracy with Gabor feature extraction. In Proc. Int. Conf. on Spoken Language

  10. Modeling and Performance Evaluation of Backoff Misbehaving Nodes in CSMA/CA Networks

    DTIC Science & Technology

    2012-08-01

    range of backoff misbehaviors on network performance in CSMA/CA-based wireless networks. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17...Layer Misbeha- vior in Wireless Networks,” ACM Trans. Information and Systems Security , vol. 11, no. 4, pp. 19:1-19:28, July 2008. [10] S. Choi, K...Park, and C. kwon Kim, “On the Performance Characteristics of WLANs : Revisited,” Proc. ACM SIGMETRICS Int’l Conf. Measurement and Modeling of Computer

  11. Contrast Analysis for Side-Looking Sonar

    DTIC Science & Technology

    2013-09-30

    Multipath ray tracing model for shallow water acoustics. In Proc. 11th Eur. Conf. Underwater Acoust., ECUA2012, Jul. 2012. • D. Cook, D. Brown, and Z. Lowe...Davis, Brian Mulvaney, and Kristin Bing. Mike Davis is a recognized expert in the field of synthetic aperture radar performance prediction, and Brian...Mulvaney is assisting with the data processing and software development. Kristin Bing is a co-author of a recent book chapter on radar ATR, and she is

  12. Computation of Laminar and Turbulent Flow in 90-Degree Square-Duct and Pipe Bends Using the Navier-Stokes Equations

    DTIC Science & Technology

    1982-04-01

    Equations of Engineering Sciace. Schaum Publishing Co. 22 1j. Roberts, G.O.: Computational Meshes for Boundary Layer Problems. Proc. 2nd Int. Conf. Num...Division of Chemistry and Chemical Engineering Code 2591 Pasadena, CA 91125 San Diego, CA 92152 Professor H.W. Liepmann Professor Richard L. Pfeffer...York University of California, San Diego Graduate Center: 33 West 42 Street Department of Chemistry New York, NY 10036 La Jolla, CA 92093 Mr. Norman M

  13. Computation of Laminar and Turbulent Flow in Curved Ducts, Channels and Pipes Using the Navier-Stokes Equations.

    DTIC Science & Technology

    1980-12-01

    34. Schaum Publishing Co. 18. Roberts, G. 0.: "Computational Meshes for Boundary Layer Problems", Proc. 2nd It. Conf. Num. Meth. Fluid Dynamics...Department of Ocean Engineering Department of Chemistry Cambridge, MA 02139 La Jolla, CA 92093 Professor Ronald W. Yeung Dr. E. W. Montroll Massachusetts...Program ’Department of Chemistry Office of Naval Research La Jolla, CA 92093 800 N. Quincy Street Arlington, VA 22217 Dr. E. W. Montroll Physical Dynartics

  14. Short-Sighted Probabilistic Planning

    DTIC Science & Technology

    2013-08-01

    approaches mentioned so far is applied by t-look- ahead [Pearl, 1985, Russel and Norvig , 2003] and Upper Confidence bound for Trees (UCT) [Kocsis and...Symbiotic Human-Robot Interaction. In Proc. of the 9th Int. Joint Conf. on Autonomous Agents and Multiagent Systems (AAMAS). [Russel and Norvig , 2003...Russel, S. J. and Norvig , P. (2003). Artificial Intelligence - A Modern Approach. Prentice Hall, 2nd edition. [Samadi et al., 2012] Samadi, M., Kollar, T

  15. Security Protocol Verification and Optimization by Epistemic Model Checking

    DTIC Science & Technology

    2010-11-05

    performance by orders of magnitude and enables problems of larger scale to be attacked. 15. SUBJECT TERMS Information security, computer science , distributed...Ron van der Meyden School of Computer Science and Engineering, University of New South Wales Abstract. The paper describes an abstraction for...agent systems. In Proc. Int. Conf. on Computer Aided Verifica- tion (CAV), volume 5643 of Lecture Notes in Computer Science , pages 682–688. Springer, 2009

  16. Fault Tolerance of Neural Networks

    DTIC Science & Technology

    1994-07-01

    Systematic Ap - proach, Proc. Government Microcircuit Application Conf. (GOMAC), San Diego, Nov. 1986. [10] D.E.Goldberg, Genetic Algorithms in Search...s l m n ttempt to develop fault tolerant neural networks. The lows. Given a well-trained network, we first eliminate temp todevlopfaut tlernt eurl ...both ap - proaches, and this resulted in very slight improve- ments over the addition/deletion procedure. 103 Fisher’s Iris data in average case Fisher’s

  17. Animal Investigation Program (AIP), A.I.P. summary report on and around the Nevada Test Site from 1982--1995

    SciTech Connect

    Giles, K.R.

    1997-04-01

    This report describes the Animal Investigation Program conducted from 1982--1995 by the Environmental Protection Agency`s (EPA`s), Radiation and Indoor Environments National Laboratory (R and IE), formerly Radiation Sciences Laboratory-Las Vegas. This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site. The surveillance program was designed to measure levels and trends of radionuclides in animals on and around the Nevada Test Site to ascertain whether world-wide fallout, current radiation levels, and associated doses, to the general public were in compliance with existing radiation protection standards. The surveillance program additionally had the responsibility to take action to protect the health and well-being of the public in the event of any accidental release of radioactive contaminants. Comparison of the measurements and sample analysis results indicated that no significant amounts of biological radionuclides had been detected in the near offsite areas or on the NTS, except in animals drinking water that drains from tunnels in Area 12.

  18. ConfChem Conference on Flipped Classroom: Time-Saving Resources Aligned with Cognitive Science to Help Instructors

    ERIC Educational Resources Information Center

    Hartman, JudithAnn R.; Dahm, Donald J.; Nelson, Eric A.

    2015-01-01

    Studies in cognitive science have verified that working memory (where the brain solves problems) can manipulate nearly all elements of knowledge that can be recalled automatically from long-term memory, but only a few elements that have not previously been well memorized. Research in reading comprehension has found that "lecture notes with…

  19. ConfChem Conference on Flipped Classroom: Just-in-Time Teaching in Chemistry Courses with Moodle

    ERIC Educational Resources Information Center

    Muzyka, Jennifer L.

    2015-01-01

    In the Just-in-Time Teaching approach, a faculty member assigns readings to students before every class. After the students have done the daily reading, they access a short reading quiz using a course management system (e.g., Moodle). The faculty member uses student responses to the quiz in the preparation of the day's class material and is able…

  20. ConfChem Conference on Flipped Classroom: Improving Student Engagement in Organic Chemistry Using the Inverted Classroom Model

    ERIC Educational Resources Information Center

    Rossi, Robert D.

    2015-01-01

    Improving student engagement in STEM (science, technology, engineering, and mathematics) courses generally, and organic chemistry specifically, has long been a goal for educators. Recently educators at all academic levels have been exploring the "inverted classroom" or "flipped classroom" pedagogical model for improving student…

  1. PROcEED: Probabilistic reverse dosimetry approaches for estimating exposure distributions

    EPA Science Inventory

    As increasing amounts of biomonitoring survey data become available, a new discipline focused on converting such data into estimates of chemical exposures has developed. Reverse dosimetry uses a pharmacokinetic model along with measured biomarker concentrations to determine the p...

  2. Proc. of the workshop on pushing the limits of RF superconductivity.

    SciTech Connect

    Kim, K-J., Eyberger, C., editors

    2005-04-13

    For three days in late September last year, some sixty experts in RF superconductivity from around the world came together at Argonne to discuss how to push the limits of RF superconductivity for particle accelerators. It was an intense workshop with in-depth presentations and ample discussions. There was added excitement due to the fact that, a few days before the workshop, the International Technology Recommendation Panel had decided in favor of superconducting technology for the International Linear Collider (ILC), the next major high-energy physics accelerator project. Superconducting RF technology is also important for other large accelerator projects that are either imminent or under active discussion at this time, such as the Rare Isotope Accelerator (RIA) for nuclear physics, energy recovery linacs (ERLs), and x-ray free-electron lasers. For these accelerators, the capability in maximum accelerating gradient and/or the Q value is essential to limit the length and/or operating cost of the accelerators. The technological progress of superconducting accelerators during the past two decades has been truly remarkable, both in low-frequency structures for acceleration of protons and ions as well as in high-frequency structures for electrons. The requirements of future accelerators demand an even higher level of performance. The topics of this workshop are therefore highly relevant and timely. The presentations given at the workshop contained authoritative reviews of the current state of the art as well as some original materials that previously had not been widely circulated. We therefore felt strongly that these materials should be put together in the form of a workshop proceeding. The outcome is this report, which consists of two parts: first, a collection of the scholarly papers prepared by some of the participants and second, copies of the viewgraphs of all presentations. The presentation viewgraphs, in full color, are also available from the Workshop Presentations link on the workshop's web page at http://www.aps.anl.gov/conferences/RFSCLimits/. I would like to thank all of the participants for their lively contributions to the workshop and to these proceedings, and Helen Edwards and Hasan Padamsee for their help in developing the workshop program. I also thank Cathy Eyberger, Kelly Jaje, and Renee Lanham for working very hard to take care of the administrative details, in particular Cathy for editing this report.

  3. 78 FR 63568 - Proposed Collection; Comment Request for Rev. Proc. 2007-35

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ..., Statistical Sampling for purposes of Section 199. DATES: Written comments should be received on or before...: Statistical Sampling for purposes of Section 199. OMB Number: 1545-2072. Revenue Procedure Number: RP-2007-35. Abstract: This revenue procedure provides for determining when statistical sampling may be used in...

  4. Proc. of the sixteenth symposium on energy engineering sciences, May 13-15, 1998, Argonne, IL.

    SciTech Connect

    1998-05-13

    This Proceedings Volume includes the technical papers that were presented during the Sixteenth Symposium on Energy Engineering Sciences on May 13--15, 1998, at Argonne National Laboratory, Argonne, Illinois. The Symposium was structured into eight technical sessions, which included 30 individual presentations followed by discussion and interaction with the audience. A list of participants is appended to this volume. The DOE Office of Basic Energy Sciences (BES), of which Engineering Research is a component program, is responsible for the long-term, mission-oriented research in the Department. The Office has prime responsibility for establishing the basic scientific foundation upon which the Nation's future energy options will be identified, developed, and built. BES is committed to the generation of new knowledge necessary to solve present and future problems regarding energy exploration, production, conversion, and utilization, while maintaining respect for the environment. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, prolonging the useful life of energy-related structures and equipment, and developing advanced manufacturing technologies and materials processing. The program emphasis is on reducing costs through improved industrial production and performance and expanding the nation's store of fundamental knowledge for solving anticipated and unforeseen engineering problems in energy technologies. To achieve these goals, the Engineering Research Program supports approximately 130 research projects covering a broad spectrum of topics that cut across traditional engineering disciplines. The program focuses on three areas: (1) mechanical sciences, (2) control systems and instrumentation, and (3) engineering data and analysis. The Sixteenth Symposium involved approximately one-fourth of the research projects currently sponsored by the DOE/BES Engineering Research Program.

  5. Building Galaxies: From the Primordial Universe to the Present, Procs of the XIXth Rencontres de Moriond

    NASA Astrophysics Data System (ADS)

    Hammer, F.; Thuan, T. X.; Cayatte, V.; Guiderdoni, B.; Thanh Van, J. T.

    The Table of Contents for the book is as follows: * Foreword * Avant-propos * I. Spectral Energy Distributions and Emission Mechanisms of Nearby Galaxies * Energy distributions and the formation times of spheroidal populations * The spectral energy distribution of spiral galaxies * The Spectral Energy distribution of an isolated spiral: the far infrared and millimeter spectrum * Dust emission in spiral disks and in central regions of barred galaxies * Pattern speeds of bars * The Nearby Field Galaxy Survey: a spectrophotometric and photometric study of 196 galaxies in the local field * Global properties of blue compact dwarf galaxies * The stellar content of blue compact dwarf galaxies * Multi-wavelength observations of the blue dwarf galaxies Haro-4 * Cometary blue compact dwarf galaxies * Stellar population gradients in the Local Group dwarf galaxy Phoenix * Photon and metal production in starburst galaxies * Spatial resolution bias in the mid-infrared starburst / AGN classification * II. Dynamics of Nearby Galaxies * Elliptical galaxies dynamics: the issues pertaining to galaxy formation * Imprints of gravo-thermal properties on the building of elliptical galaxies * Spiral galaxies and tracers of mass accretion * Properties of "superthin" galaxies * Gas content and kinematics of dwarf galaxies * Dark Matter in late-type dwarf galaxies * Accurate rotation curves and distributions of dark matter in galaxies * NGC 4548: Where is it going? * Luminosity and clustering of galaxies selected by EW (Hα) * Straburst and active galaxies as seen by ISOCAM * Inflows and outflows in the NGC 2992/3 * Kinematical view of NGC 2992 * III. Statistical Properties of Distant galaxies * Radio-continuum from distant galaxies * The Phoenix Deep Survey: a deep microjansky radio survey * The nature of the sub-mJy radio population from deep photometric and spectroscopic observations * Cosmic evolution and unified models for radio AGN * Ultra-luminous infrared galaxies at high redshifts * The future of millimetre and submillimetre cosmology * Mid and far-infrared surveys with ISO * 7 and 15 μm ISO observations the cosmic star formation rate as derived from a multi-wavelength analyses * Statistical properties of local and intermediate z galaxies * A model for the evolution of spiral galaxies "calibrated" on the Milky Way * Spectral optical properties of a UV (2000 angström) - selected galaxy sample * The chemical evolution of galaxies by successive starbursts * Properties of high redshift galaxies * The stellar population of galaxies at high redshift * Lyman break galaxies as collisional starbursts * The redshift evolution of galaxy clustering * Galaxy evolution at 0 < z < 2 from the Nicmos HDF - North * Kinematics of extreme star-forming dwarf galaxies at intermediate redshifts * Dynamics of distant normal galaxies * Cold gas, the HI 21 cm line and evolving galactic potentials * Metal abundances at high redshift * Metal abundances in the Lyman-alpha forest * A molecular monster at high redshift * Chemically consistent evolution of galaxies on cosmological timescales and the DLA galaxy population * AGN, a natural stage in galaxy evolution? * AGNs and their host galaxies * The X-ray background and the starforming history in the Universe * Gamma-ray bursts: facts and mysteries * Galaxy evolution and faint counts in the optical and IR / submn * IV. Current and Future instrumentation * SIRTF, studies of galaxy formation and evolution * The new golden age of X-ray astronomy * The Atacama Large Millimeter Array: ALMA. Application to the far-infrared background * V. Models and Theory * Determining star formation rates: methods and uncertainties * A numerical study of galaxy properties from cosmological simulations with star formation * The interplay between reionization and galaxy formation in the early universe * Cosmological evolution and halo formation * Bulge formation * Density profiles of galactic dark halos * Non-Gravitational heating and the gas halos of galaxies and X-ray clusters * On the measurement of kinetic temperature measurements in high redshift galactic halos * Galaxy clustering determined from numerical cosmological simulations * Fundamental issues in galaxy formation * Making disk galaxies in hierarchical hydrodynamical simulations * Galaxies cooked the N-body plus semi-analytic model way * Measuring the temperature of the intergalactic medium * Conference summary * List of participants * List of authors

  6. Proc, Dr. Sam, Uncle Henry, and the "Little Green Book". Interview by Charles F. Wooley.

    PubMed

    Harvey, W Proctor

    2005-01-01

    During his house staff training before World War II, Dr. W. Proctor Harvey encountered Dr. Samuel A. Levine at the Peter Bent Brigham Hospital in Boston. Following military service, Harvey returned to Boston and became Levine's first cardiology fellow. The book Clinical Auscultation of the Heart--the Little Green Book by Levine and Harvey in 1949 combined Levine's clinical wisdom with Harvey's objective phonocardiographic methods and brought an important objective dimension to the art of cardiac auscultation. Both Levine and Harvey shared experiences and friendship with Henry Christian, the first Physician-in-Chief when the new Brigham Hospital Opened in 1913. Christian, appointed Dean of the Harvard Medical School in 1908 at the age of 32, was referred to as the "Boy Dean." He held the Hersey Chair of Theory and Practice of Physic from 1908 until 1939, was one of the founding group of the American Society for Clinical Investigation, and a major force in academic medicine. Levine served as intern to Christian and then joined the Brigham medical staff in 1915. Proctor Harvey followed Henry Christian's path from their mutual hometown of Lyunchburg, VA to the Peter Bent Brigham Hospital. A series of illuminating and respectful professional interactions--initially between Christian and Levine, between Levine and Harvey in the early 1940s, and between Harvey and Christian in the 1950s--provide the background for the genesis of the Little Green Book and a remarkable example of academic heritage.

  7. VizieR Online Data Catalog: Intranight optical variability of AGN (Goyal+, 2013)

    NASA Astrophysics Data System (ADS)

    Goyal, A.; Gopal-Krishna; Wiita, P. J.; Stalin, C. S.; Sagar, R.

    2014-09-01

    Our sample of TeV blazars consists of two sets. Set 1 is derived from the list of TeV-detected extragalactic AGNs, published by Weekes (2008, AIP Conf. Ser. Vol. 1085, p. 3, table 2 of his paper). Our set 2 of TeV blazars was derived from table 1 of Abdo et al. (2010ApJ...715..429A, Cat. J/ApJ/715/429), consisting of 709 TeV-detected AGNs, which is based on 11 months of monitoring with Fermi LAT. (2 data files).

  8. 77 FR 30350 - Airport Improvement Program (AIP) Use of Mineral Revenue at Certain Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... electronically. Mail: Docket Operations, U.S. Department of Transportation, West Building, Ground Floor, Room W12... Delivery: To Docket Operations, Room W12-140 on the ground floor of the West Building, 1200 ] New Jersey... statutory requirements. This notice commences FAA's 90-day clock to provide a determination on...

  9. Multiphoton Processes: ICOMP VIII: 8th International Conference, AIP Conference Proceedings, No. 525 [APCPCS

    SciTech Connect

    DiMauro, L.F.; Freeman, R.R.; Kulander, K.C.

    2000-12-31

    Topics include: atoms in strong fields; stabilization; double ionization and multi-electron calculations; high-order harmonics; molecules in strong fields; multiphoton processes in clusters; coherent control; light sources; and relativistic effects.

  10. 75 FR 54946 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ..., such as the proximity of children and pets, to normal airport operations. In addition, not all..., and resistance to the sponsor's accommodation of those changes. At airports where the nearby residents... accommodation of new aircraft types. While the FAA supports these mitigation measures where available,...

  11. Advanced information processing system: Hosting of advanced guidance, navigation and control algorithms on AIPS using ASTER

    NASA Technical Reports Server (NTRS)

    Brenner, Richard; Lala, Jaynarayan H.; Nagle, Gail A.; Schor, Andrei; Turkovich, John

    1994-01-01

    This program demonstrated the integration of a number of technologies that can increase the availability and reliability of launch vehicles while lowering costs. Availability is increased with an advanced guidance algorithm that adapts trajectories in real-time. Reliability is increased with fault-tolerant computers and communication protocols. Costs are reduced by automatically generating code and documentation. This program was realized through the cooperative efforts of academia, industry, and government. The NASA-LaRC coordinated the effort, while Draper performed the integration. Georgia Institute of Technology supplied a weak Hamiltonian finite element method for optimal control problems. Martin Marietta used MATLAB to apply this method to a launch vehicle (FENOC). Draper supplied the fault-tolerant computing and software automation technology. The fault-tolerant technology includes sequential and parallel fault-tolerant processors (FTP & FTPP) and authentication protocols (AP) for communication. Fault-tolerant technology was incrementally incorporated. Development culminated with a heterogeneous network of workstations and fault-tolerant computers using AP. Draper's software automation system, ASTER, was used to specify a static guidance system based on FENOC, navigation, flight control (GN&C), models, and the interface to a user interface for mission control. ASTER generated Ada code for GN&C and C code for models. An algebraic transform engine (ATE) was developed to automatically translate MATLAB scripts into ASTER.

  12. Physics and Astronomy Senior Report: Classes of 1999 and 2000. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    This report provides data on students earning physics and astronomy Bachelors degrees for the academic years ending in 1999 and 2000. A survey was sent to each of the 763 degree-granting departments that confer physics degrees, and responses were received from 2,721 physics major seniors from both classes. Findings show that physics Bachelors…

  13. Graduate Student Report: First-Year Students in 1999 and 2000. AIP Report.

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Langer, Casey

    This report provides information on the size and citizenship of the incoming graduate physics and astronomy class and describes student characteristics such as gender and educational background. Data are from the American Institute of Physics Enrollments and Degrees surveys for the 1998-1999 and 1999-2000 academic years. In 1998-1999 there were…

  14. Physics and Astronomy Senior Report: Class of 2003. AIP Report, Number R-211.33

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    2006-01-01

    This report looks at the characteristics, educational experiences and the short- and long-term goals of senior-level physics and astronomy majors at a point just before their graduation. It examines the factors that influenced them to study physics or astronomy as well as what they considered important when choosing which institution to attend.…

  15. Roster of Astronomy Departments with Enrollment and Degree Data, 2002. AIP Report.

    ERIC Educational Resources Information Center

    Nicholson, Starr; Mulvey, Patrick J.

    This roster contains detailed data from the annual survey of enrollments and degrees. The survey, conducted during the 2002-2003 academic year, contains data about all degree-granting astronomy departments in the United States. Presented in this roster are the data reported by those departments for their 2001-2002 introductory astronomy course…

  16. Enrollments and Degrees Report, 2006. AIP Report Number R-151.43

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    2008-01-01

    This document reports on academic enrollments (including Fall 2006) and degrees conferred at the bachelor's, master's, and doctorate levels (including academic year 2005-2006) at colleges and universities with physics or astronomy degree-granting programs. The findings presented in this report are based on an annual survey of all the physics and…

  17. Roster of Physics Departments with Enrollment and Degree Data, 2001. AIP Report.

    ERIC Educational Resources Information Center

    Nicholson, Starr; Mulvey, Patrick J.

    This roster contains detailed data from the annual Survey of Enrollments and Degrees conducted in the 2001-2002 academic year. The roster contains data reported by physics departments in the United States for their 2000-2001 introductory course enrollments, 2000-2001 degrees, and fall 2001 undergraduate major and graduate student enrollments. Of…

  18. Physics Students from Abroad in the Post-9/11 Era. AIP Report.

    ERIC Educational Resources Information Center

    Neuschatz, Michael; Mulvey, Patrick J.

    Concerned about the impact on physics programs, the American Institute of Physics conducted a small targeted survey in 2003 covering all physics graduate programs across the United States. Responses were received from 72% of all such departments, including 75% of the 185 programs that granted doctorates in physics and 64% of the programs' that…

  19. Physics in the Two-Year Colleges: 2001-02. AIP Report.

    ERIC Educational Resources Information Center

    McFarling, Mark; Neuschatz, Michael

    This document addresses physics programs in community college in 2001-2002. The data was gathered from a list of 1,785 community colleges. A survey was mailed to the various campuses as well as sent via email yielding to a 78% response rate. Physics programs in community colleges were often so small that 43% of departments that offered physics had…

  20. Physics Students from Abroad: Monitoring the Continuing Impact of Visa Problems. AIP Report, Number R-440

    ERIC Educational Resources Information Center

    Neuschatz, Michael; Mulvey, Patrick J.

    2005-01-01

    Following the attacks of September 11, 2001, the US government set in motion a broad set of measures whose aim was to screen foreign applicants for entrance into the US, to try to identify those who it was felt might attempt to carry out further attacks. Since the 2001-02 academic year had already begun in most schools, and since it took time for…

  1. Women in Physics and Astronomy, 2005. AIP Report, Number R-430.02

    ERIC Educational Resources Information Center

    Ivie, Rachel; Ray, Kim Nies

    2005-01-01

    Despite years of continued growth, women's participation in physics remains among the lowest of any scientific field. The issue is of great concern to many in the scientific community, spawning talks at conferences, data collection efforts, and speculation about the causes of women's low participation in physics. Although women's participation in…

  2. Physics and Astronomy Senior Report: Class of 2001. AIP Report, Number R-211.32

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    2004-01-01

    About one-third of the physics majors in the class of 2001 took more than 4 years to complete their undergraduate studies. The most common reasons were receiving a double major and changing majors. There are 761 departments in the US that confer at least a bachelor's degree in physics. These programs produced 4091 bachelor's degrees in the class…

  3. Roster of Physics Departments with Enrollment and Degree Data, 2002. AIP Report.

    ERIC Educational Resources Information Center

    Nicholson, Starr; Mulvey, Patrick J.

    This roster contains detailed data from the annual Survey of Enrollments and Degrees. The survey was conducted in the 2002-2003 academic year. It includes all degree-granting physics departments in the United states. Presented in this roster are the data reported by those departments for their 2001-2002 introductory course enrollments, 2002-200…

  4. 2004 Physics & Astronomy Academic Workforce. AIP Report, Number R-392.6

    ERIC Educational Resources Information Center

    Ivie, Rachel; Guo, Stacy; Carr, Arnell

    2005-01-01

    During the spring of 2004, the Statistical Research Center (SRC) of the American Institute of Physics sent a questionnaire to all 797 degree-granting physics and astronomy departments in the US. The purpose of this questionnaire, "The Academic Workforce Survey," was to determine the number of faculty positions in physics and astronomy, the number…

  5. Untapped Talent: The African American Presence in Physics and the Geosciences. AIP Report. Number R-444

    ERIC Educational Resources Information Center

    Czujko, Roman; Ivie, Rachel; Stith, James H.

    2008-01-01

    This paper presents data covering the representation of African Americans among physics and geoscience degree recipients at each stage of the educational system. The data were collected by several statistical agencies and are here provided in far more detail than has ever been available before. By placing all the data in one place, this paper…

  6. Roster of Astronomy Departments with Enrollment Degree Data, 2001. AIP Report.

    ERIC Educational Resources Information Center

    Nicholson, Starr; Mulvey, Patrick J.

    This roster contains detailed data from the annual Survey of Enrollments and Degrees in the 2001-2002 academic year. The report contains data reported by degree-granting astronomy departments for their 2000-2001 introductory astronomy course enrollments, 2000-2001 degrees, and fall 2001 undergraduate majors and graduate student enrollments. At the…

  7. Enrollments and Degrees Report, 2003. AIP Report, Number R-151.40

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    2005-01-01

    This report is a direct result of physics and astronomy department chairpersons, faculty, and staff providing us with information on their individual programs. For the data on the class of 2003, the authors received responses from 96% of the departments. Data for the non-responding departments were estimated using responses to our survey in…

  8. Analysis of Vertiport Studies Funded by the Airport Improvement Program (AIP)

    DTIC Science & Technology

    1994-05-01

    Systems Plan Caribbean Hotel Association Caribbean Tourism Statistical Report 1986, 1987 CASP (California Aviation System Plan) 1988 (3) Center for...and tourism , particularly through the hub at San Juan’s airport (SJU), is clearly increasing. By 1991, more than 90 twin-plant industries had also been...In areas with poor infrastructure, the CTR could also transfer people directly from hub airports to hotels and resorts to avoid ground transportation

  9. 78 FR 42419 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... interpretations regarding self-fueling and aeronautical commercial activities, but offered a series of... FAA believes this is appropriate. The FAA's acceptance of a new residential through-the-fence access... (NATA) offered comments which generally concurred with FAA's interpretation of section 136 of Public...

  10. Enrollments and Degrees Report, 2005. AIP Report, Number R-151.42

    ERIC Educational Resources Information Center

    Mulvey, Patrick J.; Nicholson, Starr

    2007-01-01

    The Statistical Research Center of the American Institute of Physics has been collecting Enrollment and Degree data for over four decades. This departmental census goes out in the fall of each year to all physics and astronomy departments in the US and Puerto Rico. This report is based on data collected in the fall of 2005 from the 764 departments…

  11. State of Georgia quarterly AIP Implementation Report: October--December 1995

    SciTech Connect

    1996-01-19

    The objective of this report is to ensure the citizens of Georgia that health, safety and the environment are being protected through existing DOE programs at the Savannah River Site (SRS), through a vigorous program of independent monitoring and oversight by Georgia officials. SRS emergency plans will be annually reviewed and updated. Environmental monitoring will be conducted of surface water and related media, ground water, air, crops, milk, drinking water, soils and vegetation.

  12. Nondestructive Characterization of Materials IX, AIP Conference Proceedings, No. 497 [APCPCS

    SciTech Connect

    Green, R.E., Jr.

    1999-12-01

    The papers published in these proceedings represent the latest developments in nondestructive characterization of materials. Topics covered include: acoustic emission testing; electrical techniques; laser ultrasound; magnetic techniques; multiple techniques; optical techniques; thermal techniques; ultrasonics; vibrational techniques; x-ray, neutrons, positrons, and protons.

  13. AIP Conference Proceedings for the 19th Topical Conference on Radio Frequency Power in Plasmas

    SciTech Connect

    J. W. Burby, G. J. Kramer, C. K. Phillips and E. J. Valeo

    2012-08-15

    An analytic model for single particle motion in the presence of a wave field and multiple cyclotron harmonics is developed and investigated. The model suggests that even in the absence of Doppler broadening, cyclotron harmonic layers have finite spatial extent. This allows for particles to interact with more than one harmonic layer simultaneously, provided the layers are tightly packed. The latter phenomenon is investigated in the context of the model using symplectic mapping techniques. Then the model behavior is compared with numerical simulations of neutral beam particle trajectories in NSTX using the full-orbit code SPIRAL

  14. Plutonium Futures -- The Science. Topical Conference on Plutonium and Actinides. AIP Conference Proceedings, No. 532 [APCPCS

    SciTech Connect

    Pillay, K.K.S.; Kim, K.C.

    2000-12-31

    Presentations at this conference covered the topics of materials science/nuclear fuels, condensed matter physics, actinides in the environment/separation and analysis, actinides/processing, actinides/TRU wastes, materials science, TRU waste forms, nuclear fuels/isotopes, separations and process chemistry, actinides in the environment, detection and analysis, Pu and Pu compounds, actinide compounds and complexes.

  15. Review of Progress in Quantitative Nondestructive Evaluation, Volume 19A, AIP Conference Proceedings, No. 509, [APCPCS

    SciTech Connect

    Thompson, D.O.; Chimenti, D.E.

    2000-12-31

    This volume contains a minisymposium on innovation and nondestructive evaluation (NDE) in a global economy, then proceeds to elastic waves and ultrasonic techniques; electromagnetic, thermal, and x-ray techniques; signal processing, imaging, and inversion techniques; and ultrasonic transducers, fields, and arrays.

  16. Influence of various land uses on windbreak selection by nesting Mississippi kites

    USGS Publications Warehouse

    Love, Diane; Grzybowski, Joseph A.; Knopf, Fritz L.

    1985-01-01

    Contemporary land-use practices have dramatically altered breeding habitats of birds of prey (Cramp, pp. 9-11 in World Conf. Birds of Prey, R. D. Chancellor, ed., ICPB, London, England, 1977). Some land uses appear to influence strongly both the nesting activity (White, Trans. North Am. Wild. Nat. Resour. Conf. 39:301-312, 1974) and abundance (Olendorff and Stoddart, pp. 44-48 in Management of Raptors, F. N. Jamerstrom, B. E. Harrel, and R. R. Olendorff, eds., Proc. Conf. Raptor Conserv. Tech., Raptor Rep. 2, Fort Collins, Colorado, 1974) of raptors. The Mississippi Kite (Ictinia mississippiensis) is a locally common raptor of the south-central plains of North America. In the prairie grasslands of western Oklahoma and south-western Kansas, kites commonly nest in tree plantings designed as windbreaks, irrespective of windbreak width, age, or tree species compositions (Parker, Ph.D. Diss., Univ. Kansas, Lawrence, Kansas, 1974; Love and Knopf, Proc. Ann. Meet. For. Comm. Great Plains Agric. Counc. 30:69-77, 1978). Much of the potential nesting habitat within this region, however, is not used by kits (Parker and Ogden, Am. Birds 33:119-129, 1979). In this paper, we assess the potential influence of various land-use practices on windbreak selection by nesting Mississippi Kites.

  17. Using PROC GLIMMIX to Analyze the Animal Watch, a Web-Based Tutoring System for Algebra Readiness

    ERIC Educational Resources Information Center

    Barbu, Otilia C.

    2012-01-01

    In this study, I investigated how proficiently seventh-grade students enrolled in two Southwestern schools solve algebra word problems. I analyzed various factors that could affect this proficiency and explored the differences between English Learners (ELs) and native English Primary students (EPs). I collected the data as part of the Animal Watch…

  18. Angioplastie coronaire percutanée chez la femme: particularités cliniques, procédurales et pronostiques

    PubMed Central

    Abid, Leila; Hadrich, Morched; Sahnoun, Mohamed; Kammoun, Samir

    2011-01-01

    AbstractX Les résultats de l′angioplastie transluminale (ATL) des coronaires chez la femme ont été pendant de nombreuses années controversés et longtemps considérés comme moins favorable que chez l′homme. Le but de notre travail était d’évaluer les caractéristiques de l'angioplastie coronaire chez la femme, ainsi que les résultats immédiats et à moyen terme et de les comparer à ceux chez l'homme. Nous avons comparé 200 patients dont 100 femmes, ayant bénéficié d'une angioplastie coronaire, colligés au service de cardiologie de l'hôpital Hédi Chaker de Sfax entre 2002 et 2007. Les femmes étaient significativement plus âgées que les hommes. La comparaison de la fréquence des facteurs de risque d'athérosclérose chez les deux sexes, a permis de noter une co-morbidité franchement plus importante chez la femme, avec une différence statiquement significative. L'ATL a été plus motivée chez la femme devant un angor stable sévère (p<0,05) et un SCA ST- (p=NS). Les femmes avaient plus d'atteinte polytronculaire (p<0,05), d'atteintes des segments moyens et distaux (p<0,05) et plus des lésions serrées (p=NS), longues et calcifiées (p<0,05). 259 stents ont été déployés, un stenting direct était plus fréquent dans la population féminine (p<0,05). Le diamètre des artères féminines, assimilé à celui du stent et/ou ballon utilisé, a été significativement moins important que celui des hommes. La longueur des stents et/ou ballon utilisés, ainsi que les pressions de larguage des stents ont été plus importantes chez la population féminine (p<0,05). Le succès angiographique global a été obtenu chez 94% de la population générale, sans différence significative entre les deux sexes. Les évènements cardiaques majeurs (MACE) hospitaliers ont été plus fréquents chez la femme (p=0,05). Après un suivi moyen de 31 mois, le taux de MACE global a été significativement plus important chez la femme (39% vs. 28%, p<0,05), portant surtout sur la mortalité globale (13% vs. 3%, p<0,05). Le taux de resténose a été comparable chez les deux sexes. L'angioplastie coronaire constitue actuellement un moyen thérapeutique efficace et sur chez la femme, au prix de complications plus fréquentes. PMID:22145070

  19. The Role of Traps in the Microstructural Control of Hydrogen Embrittlement of Steels.

    DTIC Science & Technology

    1984-04-01

    Richards, Met. .4, Trans., 7A (1976), p. 821. 14. C. Hwang and l.M. Bernstein, Scriota Met., 17 (1983). Ij%15. P. Bastien and P. Azou , C.R. Acad. Sci. Paris...Conaress on Hvdroaen and Materials, Proc. 3rd Int’l Congress (P. Azou , eoa (1982) p. 491 28. A.R. Troiano, Trans. ASM, 52 (1960), p. 54. 29. R.A. Oriani, Ber...53 n. 7 (1982), p. 259. 44. K.W. Lange and H.J. Koning, 2nd Int. Conf. on Hydroaen in Metals, 1973, Paris (P. Azou , ed.) paper 1A5. 45. V.I. Saliv

  20. Louisiana Coastal Area, Louisiana. Freshwater Diversion to Barataria and Breton Sound Basins. Feasibility Study. Volume 1. Draft Main Report. Draft Environmental Impact Statement.

    DTIC Science & Technology

    1984-09-01

    bank at Big Mar are: o a 100-foot-long multi- cell box culvert control structure with nine 5- by 20-foot cells in the Mississippi River levee, o an...Davis Pond are: o a 240-foot-long multi- cell box culvert control structure with six 15- by 15-foot cells In the Mississippi River levee, o an inlet...salinity in Mobile Bay. Proc. 23rd Annual Conf. Southeastern Assoc. of Game and Fish Comm. 519-521pp. Montz, G.N. 1975a. Master List of Herbs , Ferns

  1. Metastable Transition Metal Alloys Produced by Rapid Quenching: Structure and Properties.

    DTIC Science & Technology

    1984-01-01

    of element M, or in teis of the average valtece ,lc’ron concvncr, i.n k’:iC) Llt.F-are 2). rhe VEC 414a plays an important role in the Nagel- Tauc ti...ponents, 1d respectively]; a favorable valence electron concentrntion (VEC % 2 electron.;/atom, do 11agel- Tauc model); 11 strong chemical interactions...8217 ’ 11. S.R. Nagel and J. Tauc , in Proc. Second Internat. Conf. on Raiidl qenched Metals, Section ot 1, N.J. Grant and B.C. Giessen, eds., M.I.T. Press

  2. Optoelectronic Workshops. 11. Superlattice Disordering

    DTIC Science & Technology

    1988-12-07

    34tbL LA OVE- C EL6U-Q 1" &&F EC~Corr Loi - %. 4 W7 IJJ E- L-’T SL..ytQb L6C 004i c6 > P1.16 ~ ~ w LEC - E US: 0kLkok-TP ~ Or V44A LA 0.2- 0.1- L&J. - 0.1...13 M.Wihl, P.J. Stiles and J1. Tauc , Proc. 1 Ith Intern. Conf. on the Physics of Semiconductors, Warsaw 1972, p.4 84. 14 M.A. Nizarnetdinova, Phys

  3. Relationships between Electronic Structure and Stability of Metallic Glasses.

    DTIC Science & Technology

    1984-06-01

    the experimental reflectance and transmittance values) for three consecutive values of the frequency LJi-l, o~i, LOi +I . If we assui.e that the A and...12. T. MATSUDA and U. MIZUTANI, in Proc. 4th Int. Conf. Rapidly Quenched Metals (Sendai, 1981) p. 1315. 13. J.J. HAUSER and J. TAUC , Phys. Rev. B...N.SAKAI, H. SEKIZAWA and T. MIZOGUCHI, J. Phys. ’ Soc. Japan 50, 828 (1981). 27. E. HAUSER, R.J. ZIRCKE, J. TAUC , J.J. HAUSER and S.R. NAGEL, Phys. Rev

  4. A Protocol for Topology-Dependent Transmission Scheduling in Wireless Networks

    DTIC Science & Technology

    1999-01-01

    problems of CSMA, many collision-avoidance MAC protocols have been proposed, which include MACA [4], MACAW [5], IEEE802.11 [6] and FAMA [7]. These protocols...traffic makes it much more attractive than such collision-avoidance MAC protocols as IEEE802.11, MACA, MACAW , and FAMA. REFERENCES [1] B. M. Leiner, D. L...Amateur Radio 9th Comput. Networking Conf., 1990. [5] V. Bharghavan et al., “ MACAW : A media access protocol for wireless LAN’s,” in Proc. ACM SIGCOMM

  5. Experimental Investigation of Adiabatic Shear Banding at Different Impact Velocities

    DTIC Science & Technology

    1993-01-01

    obtained for XC18 steel are compared with results for a mild steel reported by Campbell and Ferguson [48] ; composition of En3B (British Standards...chemical composition of the supplied VAR4340 steel was as follows : C 0.42 ; Ni 1.74 ; Cr 0.89 ; Mn 0.46: Si 0.28 ; S 0.001 ; P 0.009 (% wt.). About...7] C. Fressengeas, Analyse dynamique 61asto-viscoplastique de l’h6tdrogdndit6 de la ddforma- tion plastique de cisalllement, Proc. Int. Conf. on

  6. Singular Perturbations and Time-Scale Methods in Control Theory: Survey 1976-1982.

    DTIC Science & Technology

    1982-12-01

    transitions of bifurcation. SIAM J. Aocl. Math. Vol. 38, p. 249-260. [B281 Sastry, S.S. and C.A. Desoer (1981). Jump behaviour of circuits and systems. 1IEEE...Sastry, S.S. and C.A. Desoer (1983). Asymptotic unbounded root-loci formulae and computation. Proc. IEEE Conf. on Decision and Control, Vol. 1, p. 120...elec::ical network equations. Rocky Mountain 1. Math, Vol. 6, p. 709-710. (K3] Desoer , C.A. (1977). Distributed networks with small parasitic elements

  7. Generalizing the Nonlocal-Means to Super-Resolution Reconstruction

    DTIC Science & Technology

    2008-12-12

    Image Process., vol. 5, no. 6, pp. 996–1011, Jun. 1996. [7] A. J. Patti, M. I. Sezan, and M. A. Tekalp, “ Superresolution video reconstruction with...computationally efficient image superresolution algorithm,” IEEE Trans. Image Process., vol. 10, no. 4, pp. 573–583, Apr. 2001. [13] M. Elad and Y...pp. 21–36, May 2003. [18] S. Farsiu, D. Robinson, M. Elad, and P. Milanfar, “Robust shift and add approach to superresolution ,” in Proc. SPIE Conf

  8. Packing Fraction and Relation to Glass Transition in Ternary Blends of Cyanate Ester Resins (PREPRINT)

    DTIC Science & Technology

    2010-10-21

    Blends of Cyanate Ester Resins 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Andrew J. Guenthner , Joseph M. Mabry (AFRL/RZSM...Resins Kevin R. Lamison’, Andrew J. Guenthner , Vandana Vij’, and Joseph M. Mabrl. ’ERG Incorporated, Edwards AFB, CA 93524 2Propu/sion Directorate...in Proc. SPE Conf. High Temp. Po/ym. Society of Plastics Engineers: Cleveland, OH, 1989; pp. 127-140. 6. Guenthner . A. J ,; Yandek, G. R.; Wright, M

  9. Vulnerability Assessment Tools for Complex Information Networks

    DTIC Science & Technology

    2007-11-02

    Takehiro Takahashi No Cliff Zou No Yong Huang No Jie Sun No Sheng Xiao No Yan Cai No Songlin Cai No Hanping Feng No Jonathan Lee No X.C. Lin No Jinghua Hu...Transactions on Modeling and Simulation, 2004. 31. Yongguang Zhang, Wenke Lee, and Yi-an Huang , “Intrusion Detection Techniques for Mobile Wireless Networks...Energy-Efficient Wireless Networks with Real-Time Constraints", Proc. of 45th IEEE Conf. Decision and Control, pp. 2997-3002, Dec. 2006. 29. Y. Huang , W

  10. Bibliography of Short Wavelength Chemical Laser Research

    DTIC Science & Technology

    1993-05-01

    shock tube dissociation of fluorine azide, (2) identify and characterize alternatives to BiF as the lasant in an excited NF driven laser , (3) develop...L.F. Phillips KINETICS OF 12 FOLLOWING ArF LASER EXCITATION: THERMAL DISSOCIATION OF THE A’(2u) STATE J. Phys. Chem., 88, 6084 (1984) 267. Tellinghuisen...VISIBLE WAVELENGTH CHEMICAL LASER SCHEMES BASED ON THERMAL DISSOCIATION OF CHLORINE AZIDE Proc. Int. Conf on.LASERS 󈨟, Eds. F.J. Duarte and D.G. Harris

  11. Integrating Vision and Audition within a Cognitive Architecture to Track Conversations

    DTIC Science & Technology

    2008-03-01

    interaction focuses on the hypothesis that a robot that is able to think like a person is better able to interact with a person than a robot that does not [41... humanoid robot robovie. Proc. Intl Conf Robotics and Automation, 2002. [14] M. Katzenmaier, R. Stiefelhagen, and T. Schultz. Identifying the addressee in...conversation. Language, 50(4):696–735, 1974. [35] B. Scassellati. Theory of Mind for a Humanoid Robot . Autonomous Robots , 12(1):13–24, 2002. [36] A

  12. A Random Finite Set Approach to Space Junk Tracking and Identification

    DTIC Science & Technology

    2014-09-03

    Jah, “An AEGIS-FISST integrated detection and tracking approach to Space Situational Awareness,” Proc. Int. Conf. Information Fusion, pp. 2065-2072...Final 3. DATES COVERED (From - To) 31 Jan 13 – 29 Apr 14 4. TITLE AND SUBTITLE A Random Finite Set Approach to Space Junk Tracking and...Identification 5a. CONTRACT NUMBER FA2386-13-1-4010 5b. GRANT NUMBER Grant AOARD-134010 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S

  13. Formation of the YBa2Cu2NbOy Phase in Thin Films (POSTPRINT)

    DTIC Science & Technology

    2010-03-01

    addition of V2O5 and Nb2O5 into YBCO thin films . Additionally, recent initial results have demonstrated the potential use of YBa2Cu3–xNbxOy (YBCNxO) as a...S.C. Purandare: Effect of Nb2O5 and V2O5 addition on the superconducting properties of YBa2Cu3O(y) thin films . NASA Conf. Proc. 3290, 241 (1994). 9. S...AFRL-RZ-WP-TP-2010-2086 FORMATION OF THE YBa2Cu2NbOy PHASE IN THIN FILMS (POSTPRINT) Robert A. Wheeler UES, Inc. Srinivas Sathiraju

  14. Fiber-Optic Propagation Effects in Long-Haul HF/VHF/UHF Analog Photonic Links

    DTIC Science & Technology

    2014-04-17

    S., “Nonlinear index measurements of various fibre types over C+L bands using four-wave mixing,” in Proc. 27th European Conf. on Optical ...Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/5650--14-9537 Fiber- Optic Propagation Effects in Long-Haul HF/VHF/UHF Analog Photonic... Optical Sciences Division i REPORT DOCUMENTATION PAGE Form ApprovedOMB No. 0704-0188 3. DATES COVERED (From - To) Standard Form 298 (Rev. 8-98) Prescribed

  15. A Study of the 5S Ribosomal RNAs of the Vibrionaceae

    DTIC Science & Technology

    1984-01-01

    osmolarity on Vibrio cholerae. Proc. 7", Annu. Trap. Subtrop. Seafood Technol. Conf. of the Americas, pp. 224-238. MacDonell, M.T., F.L. Singleton...association and osmolarity on seawater microcosm populations of an environmental isolate of Vibrio cholerae. In R.R. Colwell (ed.), Vibrios in the...characterization and incidence. In R.R. Colwell (ed.), Vibrios in the Environment, Wiley Interscience, New York. pp. 551-562. MacDonell, M.T., E. Russek

  16. A Parameterized Pattern-Error Objective for Large-Scale Phase-Only Array Pattern Design

    DTIC Science & Technology

    2016-03-21

    only arrays,” in Proc. Int’l Conf. on Neural Networks and Signal Processing, vol. 2, 2003, pp. 1290–1293. 24. I. D. Olin, “Flat-top sector beams...failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE...transmitters will continue to offer only phase control . This considerably complicates the design of custom array patterns for transmit arrays, as all but

  17. A dc Penning Surface-Plasma Source

    DTIC Science & Technology

    2007-11-02

    LA-UR-93-2990 Title: A dc Penning Surface-Plasma Source Author(s): Submitted to: H. Vernon Smith, Jr., Paul Allison, Carl Geisik, David R...Type: HC Number of Copies In Library: 000001 Record ID: 28620 A de Penning Surface-Plasma Source* H. Vernon Smith, Jr., Paul Allison, Carl Geisik...Schechter, J. H. Whealton, and J. J. Donaghy, ATP Conf. Proc. No. 158, 366 (1987). 8) H. V. Smith, Jr., N. M. Schnurr, D. H. Whitaker , and K. E. Kalash

  18. Studies of Ionospheric Irregularities: Origins and Effects

    DTIC Science & Technology

    2009-09-30

    Humphreys, B.M. Ledvina , M.L. Psiaki, B.W. O’Hanlon, and P.M. Kintner, Jr., Proc. 2008 ION GNSS Conf., Institute of Navigation, Savanna, GA, 2008...the spoofing threat, T.E. Humphreys, B.M. Ledvina , M.L. Psiaki, B.W. O’Hanlon, and P.M. Kintner, Jr., cover story, GPS World, Jan. 1, 2009. [published...M.L. Psiaki, B.M. Ledvina , A.P. Cerruti, and P.M. Kintner, Jr., IEEE Transactions on Aerospace and Electronic Systems, 2009. [accepted, refereed

  19. Voltage Breakdown Limits at a High Material Temperature for Rapid Pulse Heating in a Vacuum

    DTIC Science & Technology

    1999-06-01

    expanding plasma from a previous pulse. One method produces a blow-off plasma through the application of laser power to the surface . This...velocity at the end of the heating pulse is 0.3 ern/us. There may well be some much hotter plasma on the surface produced by the high electric...Kristiansen, "Increasing surface flashover potential using magnetic insulation", Proc. 7th IEEE Pulse Power Conf., p812, (1989) [3] R.E. Tipton, "A 2D

  20. Advanced Radiation Theory Support Annual Report 2004

    DTIC Science & Technology

    2007-11-02

    COS 0’)f /r0 (12) j- ----dO" r-RoSO" 011), 0 r2 +R4-2rRocosO" 27 rr where E(x) is the Heaviside step function: E(x) = 1 for x > 0 and E(x) =0 for x < 0...Welch, B. V. Oliver , and D. V. Rose, "Plasma evolution from rod-pinch diodes," in Proc. 29th IEEEInt. Conf. Plasma Science, Banif, AB, Canada, May 26

  1. Finite-element modeling of soft tissue rolling indentation.

    PubMed

    Sangpradit, Kiattisak; Liu, Hongbin; Dasgupta, Prokar; Althoefer, Kaspar; Seneviratne, Lakmal D

    2011-12-01

    We describe a finite-element (FE) model for simulating wheel-rolling tissue deformations using a rolling FE model (RFEM). A wheeled probe performing rolling tissue indentation has proven to be a promising approach for compensating for the loss of haptic and tactile feedback experienced during robotic-assisted minimally invasive surgery (H. Liu, D. P. Noonan, B. J. Challacombe, P. Dasgupta, L. D. Seneviratne, and K. Althoefer, "Rolling mechanical imaging for tissue abnormality localization during minimally invasive surgery, " IEEE Trans. Biomed. Eng., vol. 57, no. 2, pp. 404-414, Feb. 2010; K. Sangpradit, H. Liu, L. Seneviratne, and K. Althoefer, "Tissue identification using inverse finite element analysis of rolling indentation," in Proc. IEEE Int. Conf. Robot. Autom. , Kobe, Japan, 2009, pp. 1250-1255; H. Liu, D. Noonan, K. Althoefer, and L. Seneviratne, "The rolling approach for soft tissue modeling and mechanical imaging during robot-assisted minimally invasive surgery," in Proc. IEEE Int. Conf. Robot. Autom., May 2008, pp. 845-850; H. Liu, P. Puangmali, D. Zbyszewski, O. Elhage, P. Dasgupta, J. S. Dai, L. Seneviratne, and K. Althoefer, "An indentation depth-force sensing wheeled probe for abnormality identification during minimally invasive surgery," Proc. Inst. Mech. Eng., H, vol. 224, no. 6, pp. 751-63, 2010; D. Noonan, H. Liu, Y. Zweiri, K. Althoefer, and L. Seneviratne, "A dual-function wheeled probe for tissue viscoelastic property identification during minimally invasive surgery," in Proc. IEEE Int. Conf. Robot. Autom. , 2008, pp. 2629-2634; H. Liu, J. Li, Q. I. Poon, L. D. Seneviratne, and K. Althoefer, "Miniaturized force indentation-depth sensor for tissue abnormality identification," IEEE Int. Conf. Robot. Autom., May 2010, pp. 3654-3659). A sound understanding of wheel-tissue rolling interaction dynamics will facilitate the evaluation of signals from rolling indentation. In this paper, we model the dynamic interactions between a wheeled probe and a

  2. Microwave Semiconductor Research-Materials, Devices and Circuits.

    DTIC Science & Technology

    1987-10-01

    PUBUCATIOt4S 1. "Graded Band-Gao AIGaAs Solar Cells Grown by Organometaltic Vapor Phase Epitay ’, D.K. W.agner and J.R. Shealy, Proc. Photovoltaics...Specialists Conf., Orlando, FL (Ma 1-4, 1984). 2. "Graded Bana-Gao p/n AIGaAs Solar Cells Grown by Orga nometaltic Vapor Phase Epitaxy" < Aaerand J.R...speed optical waveguide modulators because coplanar stripline electrodes can be utilized to apply the necessary high frequency bias signals. After

  3. Metal Contacts to Cadmium Telluride (CdTe).

    DTIC Science & Technology

    1987-10-01

    WILLIAMS, I.M. DHARMADASA, M.H. PATTERSON’, C. MAANI** and N.M. FORSYTH Physics Deparment, University College, PO Box 78, Cardiff, UK Received 10 June 1985...North-Holland Physics Publishing Division) -43- 324 R. H. Williams et al. / Metal contacts to InP and CdTe considerations of local charge neutrality near...support. References Ill L.J. Brillson. Surface Sci. Rept. 2 (1982) 123. 121 R.H. Williams. Proc. 17th Intern. Conf. on the Physics of Semiconductors

  4. Proceedings of the 34th International Conference in High Energy Physics (ICHEP08), Philadelphia, PA, 2008, eConf C080730, [hep-ph/0809.xxx

    SciTech Connect

    Lockyer, Nigel S.; Smith, AJ Stewart,; et. al.

    2008-09-01

    In 2004 a team from the University of Pennsylvania, Princeton University, and the Institute for Advanced Study proposed to host the 2008 International Conference on High Energy Physics (ICHEP) on the campus of the University of Pennsylvania in Philadelphia. The proposal was approved later that year by the C-11 committee of the International Union of Pure and Applied Physics. The Co-Chairs were Nigel S. Lockyer (U. Penn/TRIUMF) and A.J. Stewart Smith (Princeton); Joe Kroll of U. Penn served as Deputy Chair from 2007 on. Highlights of the proposal included 1. greatly increased participation of young scientists, women scientists, and graduate students 2. new emphasis on formal theory 3. increased focus on astrophysics and cosmology 4. large informal poster session (170 posters) in prime time 5. convenient, contiguous venues for all sessions and lodging 6. landmark locations for the reception and banquet. The conference program consisted of three days of parallel sessions and three days of plenary talks.

  5. Low energy weak interactions and decays. [Partial summary of presentations at XXth International Conf. on High Energy Physics, Madison, Wisc. , July 17-23, 1980

    SciTech Connect

    Trilling, G.H.

    1980-09-01

    Results presented during sessions B5 to 7 at the XXth International Conference on High Energy Physics (University of Wisconsin, Madison, July 17 to 23, 1980) are discussed. Essentially all the material presented is summarized. The sessions covered various aspects of low-energy weak interactions. The following topics are addressed: CP-invariance violation, high-statistics study of ..lambda.. beta decay, parity violation in proton-nucleus scattering at 6 GeV/c, new results on the tau, charm particle decays (direct lifetime determinations, semileptonic branching ratios, comparison of semileptonic rate with theoretical expectations, further study of charm meson decays, F decays), and neutrino oscillations. 6 figures, 9 tables. (RWR)

  6. Analysis of Chemical Bioactivity through In Vitro Profiling using ToxCast and Tox21 High-Throughput Screening (China tox. conf. TATT)

    EPA Science Inventory

    Safety assessment of drugs and environmental chemicals relies extensively on animal testing. However, the quantity of chemicals needing assessment and challenges of species extrapolation drive the development of alternative approaches. The EPA’s ToxCast and the multiagency Tox21 ...

  7. Conférence International des Sciences des Matériaux (CSM 8) Beyrouth (Liban) Possibility of Adsorption of Phenols on One Natural Bentonite

    NASA Astrophysics Data System (ADS)

    Bachir, Meghzili; Salah, Medjram Mohamed; El-fala, Boussaa Zehou; Soulard, Michel

    The capacity of adsorption of some natural changed or synthesized loam make the object in several applications to keep specific pollutants or in other techniques as in the manufacture of beauty products or medical. Tries are performed on water contaminated by known concentration of phenol. To characterize samples we undertook the techniques of diffraction in the ray X (DRX) to have information on the interleaf areas before and after adsorption and the thermograph (TG) to follow the loss of mass. The sample of bentonite pure is then analyzed by the microscopy with electronic scanning MEB-EDX to go taking up the specters of the various mineral elements and by the elementary chemical method using the fluorescence of X-rays. Analyses DRX and TG go up that there is a variation of interleaf distances and losses of masses, what confirms the presence of adsorbed phenol. Tries d 'adsorption are accomplished with an initial concentration of phenol fixed to 5 mg by varying the mass of bentonite, phenol staying in resolution is determined to spectrophotometer UV in 270 nm. Adsorption Isotherms follow well the model of Langmuir and show a quantity q max = 75 mg of phenol substances kept by gram of bentonite. What confirms that purification by the adsorption can be accomplished or not according to the initial rate in phenol in water as well as an estimate of the mass of adsorbent who can reduce concentration of pollutants of an important manner.

  8. On a question of Gross

    NASA Astrophysics Data System (ADS)

    Banerjee, Abhijit

    2007-03-01

    Using the notion of weighted sharing of sets we prove two uniqueness theorems which improve the results proved by Fang and Qiu [H. Qiu, M. Fang, A unicity theorem for meromorphic functions, Bull. Malaysian Math. Sci. Soc. 25 (2002) 31-38], Lahiri and Banerjee [I. Lahiri, A. Banerjee, Uniqueness of meromorphic functions with deficient poles, Kyungpook Math. J. 44 (2004) 575-584] and Yi and Lin [H.X. Yi, W.C. Lin, Uniqueness theorems concerning a question of Gross, Proc. Japan Acad. Ser. A 80 (2004) 136-140] and thus provide an answer to the question of Gross [F. Gross, Factorization of meromorphic functions and some open problems, in: Proc. Conf. Univ. Kentucky, Lexington, KY, 1976, in: Lecture Notes in Math., vol. 599, Springer, Berlin, 1977, pp. 51-69], under a weaker hypothesis.

  9. Characterization and evaluation of boron carbide for plate-impact conditions

    SciTech Connect

    Holmquist, T. J.; Johnson, G. R.

    2006-11-01

    This article addresses the response of boron carbide (B{sub 4}C) to high-velocity impact. The authors previously characterized this material in 1999, using the Johnson-Holmquist [AIP Conf. Proc. 309, 981 (1994)] (JH-2) model. Since then, there have been additional experimental data presented in the literature that better describe the hydrostatic pressure (including a phase change). In addition, a series of plate-impact experiments (one-dimensional, uniaxial strain) that used configurations that produced either a shock, a shock release, or a shock reshock was performed. These experiments provide material behavior regarding the damage, failed strength, and hydrostat for which previously there has been little or no data. Constitutive model constants were obtained for the Johnson-Holmquist-Beissel [J. Appl. Phys. 94, 1639 (2003)] model using some of these plate-impact experiments. Computations of all the experiments were performed and analyzed to better understand the material response. The analysis provided the following findings: (1) The material fails and loses strength when the Hugoniot elastic limit (HEL) is exceeded. (2) The material has significant strength after failure and gradually increases as the pressure increases. (3) The shear modulus does not degrade when the material fails (as has been postulated), but rather increases. (4) When the material is reloaded from an initial shocked (failed) state, the loading appears to be elastic, indicating the material is not on the yield surface after failure. To provide more insight into the behavior of B{sub 4}C, the strength versus pressure response was compared to that of silicon carbide (SiC). The strength of SiC increases as the pressure increases beyond the HEL, probably due to pressure hardening or strain hardening. It appears that B{sub 4}C does not experience any hardening effects and fails at the HEL. Although the HEL for B{sub 4}C is higher than that of SiC, the hardening ability of SiC produces a similar

  10. A miniature laser ablation mass spectrometer for quantitative in situ chemical composition investigation of lunar surface

    NASA Astrophysics Data System (ADS)

    Brigitte Neuland, Maike; Grimaudo, Valentine; Mezger, Klaus; Moreno-García, Pavel; Riedo, Andreas; Tulej, Marek; Wurz, Peter

    2016-04-01

    surface processes on a planetary surface. Analyses of Pb isotopes show that the statistical uncertainty for the age determination by LMS is about ±100 Myrs, if abundance of 206Pb and 207Pb is 20ppm and 2ppm respectively [Riedo,2013]. These Pb isotopes have abundances of tens to hundreds of ppm in lunar KREEP [Nemchin,2008]. We demonstrate the measurement capabilities of LMS for petrographic and mineralogical analyses, for isotopic studies and dating analyses, which are key topics for future missions to the Moon. Having the LMS instrument installed on a lunar rover would allow measuring the chemical composition of many rock and soil samples, distributed over a certain area, inside the South Pole Aitken Basin for example. LMS measurements would yield valuable conclusions about age and mineralogy. References: [Wurz,2009]Wurz,P. et al. 2009, AIP Conf.Proc., CP1144:70-75. [Grimaudo,2015]Grimaudo, V. et al. 2015, Anal.Chem. 87: 2037-2041. [Neuland,2014]Neuland, M.B. et al. 2014, Planet.Space Sci.101:196-209. [Neuland,2016]Neuland M.B. et al. 2016, Meas. Sci. Technol.,submitted. [Riedo,2013]Riedo A. et al., 2013 Planet. Space Sci. 87: 1-13. [Nemchin,2008]Nemchin et al., 2008 Geochim. Cosmochim.Acta 72:668-689.

  11. Chemical and mineralogical analyses of planetary rocks using a laser ablation mass spectrometer for in situ space research

    NASA Astrophysics Data System (ADS)

    Brigitte Neuland, Maike; Mezger, Klaus; Riedo, Andreas; Tulej, Marek; Wurz, Peter

    2015-04-01

    . With the current spatial resolution, grain-sized inclusions embedded in the surface (e.g. CAIs, dark inclusions, metal grains) could be identified. Detailed investigations, e.g. differentiation of chondrule components from rims of chondrules can be derived from LMS data. LMS has capabilities for highly sensitive chemical composition measurements of grain sized inclusions and sub-micrometre sized surface layers. The latter information is of considerable interest in the context of space weathering. References [1] P. Wurz, et al., 2009, AIP Conf.Proc. , CP1144:70-75. [2] P. Wurz et al.,2012, Sol. Sys. Res. 46 408-422. [3] U. Rohner, J. Whitby, and P. Wurz, 2003, Meas. Sci. Technol., 14 2159-2164. [4] A. Riedo et al.,2013, J.Anal.Atom.Spectrom. 28(8):1133-1356. [5] A. Riedo, et al., 2013, J. Mass Spectrom.48, 1-15. [6] M.B. Neuland et al.,2014, Planet. Space. Sci. 101, 196-209. [7] V. Grimaudoet al.,2014, Anal. Chem., submitted.

  12. Exploring Jupiter's icy moons with old techniques and big facilities - new insights on sulfuric acid hydrates

    NASA Astrophysics Data System (ADS)

    Maynard-Casely, H. E.; Avdeev, M.; Brand, H.; Wallwork, K.

    2013-12-01

    ., AIP Conf Proc, 2007. 879: p. 879-882. [5] Liss, K.D., et al., Phys B-Cond Mat, 2006. 385-86: p. 1010-1012. [6] Maynard-Casely, H.E., K.S. Wallwork, and M. Avdeev, (In review). [7] Maynard-Casely, H.E., H.E.A. Brand, and K.S. Wallwork, J.of App.Cryst, 2012. 45: p.1198-1207. [8] Maynard-Casely, H.E., K.S. Wallwork, and H.E.A. Brand, (In Preparation). Stages of the crystal structure determination of sulfruic acid octahydrate a) the oxygen and sulfur postions were determined from the synchrotron x-ray data b) Once neutron diffraction data was collected Fourier difference methods were used to locate hydrogen positions to determine c) the full structure of sulfuric acid octahydrate.

  13. Double-negative metamaterial research for accelerator applications

    NASA Astrophysics Data System (ADS)

    Antipov, S.; Spentzouris, L.; Gai, W.; Liu, W.; Power, J. G.

    2007-09-01

    Material properties are central to the design of particle accelerators. One area of advanced accelerator research is to investigate novel materials and structures and their potential use in extending capabilities of accelerator components. Within the past decade a new type of artificially constructed material having the unique property of simultaneously negative permittivity and permeability has been realized, and is under intense investigation, primarily by the optical physics and microwave engineering communities [C.M. Soukoulis, Science 315 (2007) 47; D.R. Smith, J.B. Pendry, M.C.K. Wiltshire, Science 305 (2004) 788; J.B. Pendry, A.J. Holden, W.J. Stewart, I. Youngs, Phys. Rev. Lett. 76 (1996) 4773]. Although they are typically constructed of arrays of discrete cells, as long as the condition that the wavelength of applied radiation is significantly greater than the cell dimensions is met, the material mimics a continuous medium and can be described with the bulk properties of permittivity, ɛ, and permeability, μ. When the permittivity and permeability are simultaneously negative in some frequency range, the metamaterial is called double negative (DNM) or left-handed (LHM) and has unusual properties, such as a negative index of refraction. An investigation of these materials in the context of accelerators is being carried out by IIT and the Argonne Wakefield Accelerator Facility [S. Antipov, W. Liu, W. Gai, J. Power, L. Spentzouris, AIP Conf. Proc. 877 (2006); S. Antipov, W. Liu, J. Power, L. Spentzouris, Design, Fabrication, and Testing of Left-Handed Metamaterial, Wakefield Notes at Argonne Wakefield Accelerator, ]. Waveguides loaded with metamaterials are of interest because the DNM can change the dispersion relation of the waveguide significantly. For example, slow backward waves can be produced in a DNM-loaded waveguide without having corrugations. This article begins with a brief introduction of known design

  14. Initial Employment Report: Physics and Astronomy Degree Recipients of 2003 & 2004. AIP Report. Number R-282.26

    ERIC Educational Resources Information Center

    Tesfaye, Casey Langer; Mulvey, Patrick J.

    2007-01-01

    This report describes the initial employment and educational paths pursued by physics and astronomy degree recipients at the bachelor's, master's, and PhD levels for the classes of 2002-03 and 2003-04. The report includes starting salaries, primary work activities, ratings of professional challenge and other aspects of initial employment. The…

  15. Sample MMM manuscript for submission to AIP advances transient line starting analysis of the ultra-high speed PMSM.

    PubMed

    Cheng, Wenjie; Li, Wei; Xiao, Ling; Li, Ming; Tian, Yongsheng; Sun, Yanhua; Yu, Lie

    2017-05-01

    Aiming at the ultra high speed permanent magnet synchronous motor (PMSM) supported by gas foil bearings (GFBs), this paper calculates the transient line starting of the motor. Firstly, the start effect of the rotor composed of cylindrical PM and stainless steel sleeve is studied. Then, in order to enhance the start torque, copper ring, nickel ring and copper squirrel-cage are introduced in the rotor and their start effect are analysed, respectively. It can be found that the rotor including nickel ring can be accelerated to set speed, but all the other rotors are failed due to the higher PM and braking torques. It can be concluded that some material owning slight large relative permeability can be applied in the rotor to reduce the PM field and contribute to start by using the line-start method.

  16. Sample MMM manuscript for submission to AIP advances transient line starting analysis of the ultra-high speed PMSM

    PubMed Central

    Cheng, Wenjie; Li, Wei; Xiao, ling; Li, Ming; Tian, Yongsheng; Sun, Yanhua; Yu, Lie

    2017-01-01

    Aiming at the ultra high speed permanent magnet synchronous motor (PMSM) supported by gas foil bearings (GFBs), this paper calculates the transient line starting of the motor. Firstly, the start effect of the rotor composed of cylindrical PM and stainless steel sleeve is studied. Then, in order to enhance the start torque, copper ring, nickel ring and copper squirrel-cage are introduced in the rotor and their start effect are analysed, respectively. It can be found that the rotor including nickel ring can be accelerated to set speed, but all the other rotors are failed due to the higher PM and braking torques. It can be concluded that some material owning slight large relative permeability can be applied in the rotor to reduce the PM field and contribute to start by using the line-start method. PMID:28105384

  17. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

    PubMed Central

    Kueh, Hao Yuan; Charras, Guillaume T.; Mitchison, Timothy J.; Brieher, William M.

    2008-01-01

    Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We here image the disassembly of single actin filaments by cofilin, coronin, and actin-interacting protein 1, a purified protein system that reconstitutes rapid, monomer-insensitive disassembly (Brieher, W.M., H.Y. Kueh, B.A. Ballif, and T.J. Mitchison. 2006. J. Cell Biol. 175:315–324). In this three-component system, filaments disassemble in abrupt bursts that initiate preferentially, but not exclusively, from both filament ends. Bursting disassembly generates unstable reaction intermediates with lowered affinity for CapZ at barbed ends. CapZ and cytochalasin D (CytoD), a barbed-end capping drug, strongly inhibit bursting disassembly. CytoD also inhibits actin disassembly in mammalian cells, whereas latrunculin B, a monomer sequestering drug, does not. We propose that bursts of disassembly arise from cooperative separation of the two filament strands near an end. The differential effects of drugs in cells argue for physiological relevance of this new disassembly pathway and potentially explain discordant results previously found with these drugs. PMID:18663144

  18. MATHEMATICAL MODEL FOR METHANE PRODUCTION FROM LANDFILL BIOREACTOR - A DISCUSSION PAPER HTTP://OIPS.AIP.ORG/EEO/

    EPA Science Inventory

    This discussion explains the experimental results of a landfill bioreactor (LFBR) from a microbiological perspective and provides a feasible strategy to evaluate methane production performance, since suitable models are complicated and not sufficiently reliable for anaerobic-syst...

  19. Initial Employment Report: Physics and Astronomy Degree Recipients of 2002 & 2003. AIP Report, Number R-282.25

    ERIC Educational Resources Information Center

    Langer, Casey; Mulvey, Patrick J.

    2005-01-01

    Physics and Astronomy Degree Recipients face a variety of career and educational choices once they receive their degree. The decisions that they make are affected by a wide range of influences, such as student experiences, evolving interests, family issues, personal finances, long-term career goals, and the economic conditions they encounter. This…

  20. Physics and Society: A sub-discipline of Physics

    NASA Astrophysics Data System (ADS)

    Hafemeister, David

    2012-03-01

    The Forum on Physics and Society was born in the tumultuous 1960's and 70's and has a long record of accomplishments over the past 40 years. *303 APS session in 40 years, an average of 7.7/year. *10 Books (3 Forum Studies, 7 AIP Conf. Proceedings, 4 booklets). *Physics and Society has published results that have been widely referenced. *2 Forum Board Members became U.S. Congressmen [V. Ehlers (R-MI), R. Holt (D-NJ)], others have had notable public service careers. *Szilard and Burton-Forum Awards recognize positive contributions of physicists in society. *The Forum helped establish the Congressional Science Fellowships. This talk will update the 1999 Forum History (http://www.aps.org/units/fps/history.cfm) and provide anecdotal humor. Lastly, back-of-the-envelope calculations from my text, Physics of Society Issues: Calculations on National Security, Environment and Energy (Springer, 2007), will be provided.

  1. Enhanced life ion source for germanium and carbon ion implantation

    SciTech Connect

    Hsieh, Tseh-Jen; Colvin, Neil; Kondratenko, Serguei

    2012-11-06

    Germanium and carbon ions represent a significant portion of total ion implantation steps in the process flow. Very often ion source materials that used to produce ions are chemically aggressive, especially at higher temperatures, and result in fast ion source performance degradation and a very limited lifetime [B.S. Freer, et. al., 2002 14th Intl. Conf. on Ion Implantation Technology Proc, IEEE Conf. Proc., p. 420 (2003)]. GeF{sub 4} and CO{sub 2} are commonly used to generate germanium and carbon beams. In the case of GeF{sub 4} controlling the tungsten deposition due to the de-composition of WF{sub 6} (halogen cycle) is critical to ion source life. With CO{sub 2}, the materials oxidation and carbon deposition must be controlled as both will affect cathode thermionic emission and anti-cathode (repeller) efficiencies due to the formation of volatile metal oxides. The improved ion source design Extended Life Source 3 (Eterna ELS3) together with its proprietary co-gas material implementation has demonstrated >300 hours of stable continuous operation when using carbon and germanium ion beams. Optimizing cogas chemistries retard the cathode erosion rate for germanium and carbon minimizes the adverse effects of oxygen when reducing gas is introduced for carbon. The proprietary combination of hardware and co-gas has improved source stability and the results of the hardware and co-gas development are discussed.

  2. The Spherical Tokamak MEDUSA for Costa Rica

    NASA Astrophysics Data System (ADS)

    Ribeiro, Celso; Vargas, Ivan; Guadamuz, Saul; Mora, Jaime; Ansejo, Jose; Zamora, Esteban; Herrera, Julio; Chaves, Esteban; Romero, Carlos

    2012-10-01

    The former spherical tokamak (ST) MEDUSA (Madison EDUcation Small Aspect.ratio tokamak, R<0.14m, a<0.10m, BT<0.5T, Ip<40kA, 3ms pulse)[1] is in a process of donation to Costa Rica Institute of Technology. The main objective of MEDUSA is to train students in plasma physics /technical related issues which will help all tasks of the very low aspect ratio stellarator SCR-1(A≡R/>=3.6, under design[2]) and also the ongoing activities in low temperature plasmas. Courses in plasma physics at undergraduate and post-graduate joint programme levels are regularly conducted. The scientific programme is intend to clarify several issues in relevant physics for conventional and mainly STs, including transport, heating and current drive via Alfv'en wave, and natural divertor STs with ergodic magnetic limiter[3,4]. [1] G.D.Garstka, PhD thesis, University of Wisconsin at Madison, 1997 [2] L.Barillas et al., Proc. 19^th Int. Conf. Nucl. Eng., Japan, 2011 [3] C.Ribeiro et al., IEEJ Trans. Electrical and Electronic Eng., 2012(accepted) [4] C.Ribeiro et al., Proc. 39^th EPS Conf. Contr. Fusion and Plasma Phys., Sweden, 2012

  3. Electron temperature response to ECRH on FTU tokamak in transient conditions.

    NASA Astrophysics Data System (ADS)

    Jacchia, A.; Bruschi, A.; Cirant, S.; Granucci, G.; Sozzi, C.; de Luca, F.; Amadeo, P.; Bracco, G.; Tudisco, O.

    2001-10-01

    Steady-state electron heat transport analysis of FTU high density plasmas under Electron Cyclotron Heating (ECRH) shows "stiff" electron temperature profiles [1,2,3]. Plasma response to off-axis EC heating, in fact, exibits a lower limit to electron temperature gradient length, Lc , below which electron thermal conductivity switches to higher values. Stiffness, however, is attenuated in the plasma core of saw-tooth free discharges with flat-hollow temperature profile and during current ramp-up [3,4,5], in which cases the temperature gradient length can be brought to very low values by means of on-axis ECH. Steady and current ramp-up discharges probed by steady and modulated ECH are analyzed in terms of stiffnes. Critical gradient length dependence on local features of computed current density profile is discussed. [1] Sozzi, C. et al., Paper EXP5/13, Plasma Phys. Contr. Fus. Res., Proc.18th IAEA Conf., Sorrento, 2000. [2] Jacchia, A. et al. Topical Conference on Radio Frequency Power in Plasmas, Oxnard, USA, (2001). [3] Cirant, S. et al. Topical Conference on Radio Frequency Power in Plasmas, Oxnard, USA, (2001). [4] Sozzi, C. et al., EPS, Madeira 2001. [5] Bracco, G. et al.,Plasma Phys. Contr. Fus. Res., Proc.18th IAEA Conf., Sorrento, 2000.

  4. Resonance Ionization of Heavy Noble Gases: The Potential of KR and Xe Measurements from Single Pre-Solar Grains

    NASA Astrophysics Data System (ADS)

    Thonnard, N.

    1995-09-01

    routine noble gas measurements from terrestrial and extraterrestrial samples. The present system, data illustrating current capabilities, and improvements that should reduce the detection limit significantly below 100 atoms for both Kr and Xe will be described. An early application will be simultaneous Kr and Xe isotopic measurements from single microscopic interstellar SiC grains. References: [1]Reynolds J. H. (1960) Phys. Rev. Lett., 4, 351-354. [2] Reynolds J. H. and Turner G. (1964) J. Geo. Phys. Res., 69, 3263-3281. [3] Lee T. (1988) (J. F. Kerridge and M. S. Matthews, eds.), 1063-1089, Univ. of Arizona, Tucson. [4] Anders A. and Zinner E. (1993) Meteoritics, 28, 490-514. [5] Burbidge E. M. et al. (1957) Rev. Mod. Phys., 29, 547-650. [6] Lewis R. S. et al. (1994) GCA, 58, 471-494. [7] Zinner E. et al. (1989) GCA, 53, 730-732. [8] Amari S. et al. (1992) Astrophys. J. Lett., 394, L43-L46. [9] Hohenberg C. M. et al. (1990) GCA, 54, 2133-2140. [10] Nichols R. H. Jr. et al. (1991) Meteoritics, 26. [11] Nichols R. H. Jr. et al. (1993) Meteoritics, 28, 410-411. [12] Nittler L. et al. (1995) LPS XXVI, 1057-1058. [13]Hohenberg C. M. (1994) personal communication. [14]Payne M. G. et al. (1994) Rev. Sci. Instrum., 65, 2433-2459. [15] Thonnard N. et al. (1992) Inst. Phys. Conf. Ser. 128, 27-30. [16] Gilmour J. D. et al. (1994) Rev. Sci. Instrum., 65, 617-625. [17] Thonnard N. and Lehmann B. L. (1995) AIP Conf. Proc., 329, 335-338.

  5. Endangered and Extinct Radioactivity

    NASA Astrophysics Data System (ADS)

    Leising, M. D.

    1993-07-01

    difficult to understand for any standard supernova models. This situation is puzzling. Searches for 60Fe gamma rays have also produced only upper limits, corresponding to a limit of 1.7 M(sub)solar mass in the present interstellar medium. Given the usual assumption of steady state between production and decay, the current rate of synthesis of 60Fe is less than 1.7 M(sub)solar mass/2.2 m.y. It has been suggested that a neutron-rich NSE occurs in small regions in both Type Ia supernovae supernovae and in core-collapse supernovae [7]. Either type might eject significant quantities of 60Fe. If we know the frequency of a particular type of 60Fe-producing event in the past few million years, then we can limit the mean 60Fe mass ejected per event. We have M(sub)ej (60Fe) <= 8 x 10^-5/R(SN) M(sub)solar mass where R(sub)SN is the frequency of the supernovae that eject 60Fe, in number per century. Type Ia supernovae might eject roughly 10^-4 M(sub)solar mass of 60Fe [8], which is very close to this limit. References: [1] Leising M. D. and Share G. H. (1990) Astrophys. J., 357, 638. [2] Kurfess J. D. et al. (1992) Astrophys. J. Lett., 399, L137. [3] Clayton D. D. et al. (1993) Astrophys. J. Lett., submitted. [4] Nomoto K. et al. (1984) Astrophys. J., 286, 644. [5] Woosley S. E. (1988) Proc. Astron. Soc. Aust., 7, 355. [6] Leising M. D. and Share G. H. (1993) Astrophys. J., submitted. [7] Hartmann D. H. et al. (1985) Astrophys. J., 297, 837. [8] Woosley S. E. (1991) In Gamma-Ray Line Astrophysics (P. Durouchoux and N. Prantzos, eds.), 270-290, AIP Conf. Proc. No. 232, New York.

  6. Molecular Cloning and Evidence for Osmoregulation of the Δ1-Pyrroline-5-Carboxylate Reductase (proC) Gene in Pea (Pisum sativum L.) 12

    PubMed Central

    Williamson, Cynthia L.; Slocum, Robert D.

    1992-01-01

    Several cDNA clones encoding Δ1-pyrroline-5-carboxylate reductase (P5CR, l-proline:NAD[P]+ 5-oxidoreductase, EC 1.5.1.2), which catalyzes the terminal step in proline biosynthesis, were isolated from a pea leaf library screened with a 32P-labeled Aval fragment of a soybean nodule P5CR cDNA (A.J. Delauney, D.P.S. Verma [1990] Mol Gen Genet 221: 299-305). DNA sequence analysis of one full-length 1.3-kb clone (pPPS3) indicated that the pea P5CR gene contains a single major open reading frame encoding a polypeptide of 28,242 Da. Genomic analysis suggested that two to three copies of the P5CR gene are present per haploid genome in pea. The primary structure of pea P5CR is 85% identical with that of soybean and exhibits significant homology to human, yeast, and Escherichia coli P5CR. The sequence of one of four highly conserved domains found in all prokaryotic and eukaryotic P5CRs is similar to the consensus sequence for the NAD(P)H-binding site of other enzymes. The pea P5CR cDNA hybridized to two transcripts, 1.3 and 1.1 kb in size, in polyadenylated RNA purified from leaf tissues of mature, light-grown plants (4 weeks old). Only the 1.3-kb transcript was detected in younger (1 week old) greened seedlings or in etiolated seedlings. In greened seedlings, steady-state levels of this 1.3-kb mRNA increased approximately 5-fold in root tissues within 6 h after plants were irrigated with 0.4 m NaCl, suggesting that expression of the P5CR gene is osmoregulated. Images Figure 3 Figure 4 Figure 5 PMID:11537868

  7. Experimental Assessment Parameters and Procedures for Characterisation of Advanced Thermal Imagers (Parametres et proc’edures d’evaluation experimentale pour la caracterisation d’imageurs thermiques avances)

    DTIC Science & Technology

    2007-11-02

    norm and not the exception. Staring array sensors are quickly making their way into target acquisition and surveillance/reconnaissance applications ...program. It should not be the part-time goal of a Technical Group. 2. Note that for the immediate future, there will be mis- applications of the current...sont maintenant la norme et non plus l’exception. Aujourd’hui, les capteurs fixes trouvent de plus en plus d’applications dans les domaines de

  8. Nonlinear {omega}*-stabilization of the m = 1 mode in tokamaks

    SciTech Connect

    Rogers, B.; Zakharov, L.

    1995-08-01

    Earlier studies of sawtooth oscillations in Tokamak Fusion Test Reactor supershots (Levinton et al, Phys. Rev. Lett. 72, 2895 (1994); Zakharov, et al, Plasma Phys. and Contr. Nucl. Fus. Res., Proc. 15th Int. Conf., Seville 1994, Vienna) have found an apparent contradiction between conventional linear theory and experiment: even in sawtooth-free discharges, the theory typically predicts instability due to a nearly ideal m = 1 mode. Here, the nonlinear evolution of such mode is analyzed using numerical simulations of a two-fluid magnetohydrodynamic (MHD) model. We find the mode saturates nonlinearly at a small amplitude provided the ion and electron drift-frequencies {omega}*{sub i,e} are somewhat above the linear stability threshold of the collisionless m = 1 reconnecting mode. The comparison of the simulation results to m = 1 mode activity in TFTR suggests additional, stabilizing effects outside the present model are also important.

  9. Some case studies of geophysical exploration of archaeological sites in Yugoslavia

    NASA Astrophysics Data System (ADS)

    Komatina, Snezana; Timotijevic, Zoran

    1999-03-01

    One of the youngest branches of environmental geophysics application is the preservation of national heritage. Numerous digital techniques developed for exploration directed to urban planning can also be applied to investigations of historic buildings. In identifying near-surface layers containing objects of previous civilizations, various sophisticated geophysical methods are used. In the paper, application of geophysics in quantification of possible problems necessary to be carried out in order to get an archaeological map of some locality is discussed [Komatina, S., 1996]. Sophisticated geophysical methods in the preservation of national heritage. Proc. of Int. Conf. Architecture and Urbanism at the turn of the Millenium, Beograd, pp. 39-44. Finally, several examples of archaeogeophysical exploration at Divostin, Bedem and Kalenic monastery localities (Serbia, Yugoslavia) are presented.

  10. A Fixed-point Scheme for the Numerical Construction of Magnetohydrostatic Atmospheres in Three Dimensions

    NASA Astrophysics Data System (ADS)

    Gilchrist, S. A.; Braun, D. C.; Barnes, G.

    2016-12-01

    Magnetohydrostatic models of the solar atmosphere are often based on idealized analytic solutions because the underlying equations are too difficult to solve in full generality. Numerical approaches, too, are often limited in scope and have tended to focus on the two-dimensional problem. In this article we develop a numerical method for solving the nonlinear magnetohydrostatic equations in three dimensions. Our method is a fixed-point iteration scheme that extends the method of Grad and Rubin ( Proc. 2nd Int. Conf. on Peaceful Uses of Atomic Energy 31, 190, 1958) to include a finite gravity force. We apply the method to a test case to demonstrate the method in general and our implementation in code in particular.

  11. Detection and localization of change points in temporal networks with the aid of stochastic block models

    NASA Astrophysics Data System (ADS)

    De Ridder, Simon; Vandermarliere, Benjamin; Ryckebusch, Jan

    2016-11-01

    A framework based on generalized hierarchical random graphs (GHRGs) for the detection of change points in the structure of temporal networks has recently been developed by Peel and Clauset (2015 Proc. 29th AAAI Conf. on Artificial Intelligence). We build on this methodology and extend it to also include the versatile stochastic block models (SBMs) as a parametric family for reconstructing the empirical networks. We use five different techniques for change point detection on prototypical temporal networks, including empirical and synthetic ones. We find that none of the considered methods can consistently outperform the others when it comes to detecting and locating the expected change points in empirical temporal networks. With respect to the precision and the recall of the results of the change points, we find that the method based on a degree-corrected SBM has better recall properties than other dedicated methods, especially for sparse networks and smaller sliding time window widths.

  12. Comparison of Moderate to High Ion Cyclotron Absorption on Energetic Ions in NSTX and DIII-D

    NASA Astrophysics Data System (ADS)

    Burby, J.; Pinsker, R. I.; Choi, M.

    2009-11-01

    Strong absorption of fast waves (FWs) on injected deuterons at ion cyclotron harmonic numbers in the 4-10 range is observed on both DIII-D and NSTX. The results from fast ion Dα spectroscopic measurements from the two devices differ significantly: deposition on fast ions peaks near the cyclotron harmonic layer closest to the magnetic axis in the conventional-aspect-ratio DIII-D, while results from the low-aspect-ratio NSTX show a broader deposition profile [1]. One root of the difference stems from the absorbing fast ions sampling more harmonic layers in NSTX than in DIII-D. We investigate cyclotron absorption in cases with multiple harmonic layers within a single ion gyroradius and related phenomena numerically and analytically by examining the response of individual charged particles to rf fields in various field configurations. 8pt [1] M. Podesta et al., RF Power in Plasmas (Proc.18th Top. Conf., Gent, Belgium, 2009), to be published.

  13. An exploration of advanced X-divertor scenarios on ITER

    NASA Astrophysics Data System (ADS)

    Covele, B.; Valanju, P.; Kotschenreuther, M.; Mahajan, S.

    2014-07-01

    It is found that the X-divertor (XD) configuration (Kotschenreuther et al 2004 Proc. 20th Int. Conf. on Fusion Energy (Vilamoura, Portugal, 2004) (Vienna: IAEA) CD-ROM file [IC/P6-43] www-naweb.iaea.org/napc/physics/fec/fec2004/datasets/index.html, Kotschenreuther et al 2006 Proc. 21st Int. Conf. on Fusion Energy 2006 (Chengdu, China, 2006) (Vienna: IAEA), CD-ROM file [IC/P7-12] www-naweb.iaea.org/napc/physics/FEC/FEC2006/html/index.htm, Kotschenreuther et al 2007 Phys. Plasmas 14 072502) can be made with the conventional poloidal field (PF) coil set on ITER (Tomabechi et al and Team 1991 Nucl. Fusion 31 1135), where all PF coils are outside the TF coils. Starting from the standard divertor, a sequence of desirable XD configurations are possible where the PF currents are below the present maximum design limits on ITER, and where the baseline divertor cassette is used. This opens the possibility that the XD could be tested and used to assist in high-power operation on ITER, but some further issues need examination. Note that the increased major radius of the super-X-divertor (Kotschenreuther et al 2007 Bull. Am. Phys. Soc. 53 11, Valanju et al 2009 Phys. Plasmas 16 5, Kotschenreuther et al 2010 Nucl. Fusion 50 035003, Valanju et al 2010 Fusion Eng. Des. 85 46) is not a feature of the XD geometry. In addition, we present an XD configuration for K-DEMO (Kim et al 2013 Fusion Eng. Des. 88 123) to demonstrate that it is also possible to attain the XD configuration in advanced tokamak reactors with all PF coils outside the TF coils. The results given here for the XD are far more encouraging than recent calculations by Lackner and Zohm (2012 Fusion Sci. Technol. 63 43) for the Snowflake (Ryutov 2007 Phys. Plasmas 14 064502, Ryutov et al 2008 Phys. Plasmas 15 092501), where the required high PF currents represent a major technological challenge. The magnetic field structure in the outboard divertor SOL (Kotschenreuther 2013 Phys. Plasmas 20 102507) in the recently created

  14. CORRIGENDUM: Normalization of natural gas composition data measured by gas chromatography Normalization of natural gas composition data measured by gas chromatography

    NASA Astrophysics Data System (ADS)

    Milton, Martin J. T.; Harris, Peter M.; Brown, Andrew S.; Cowper, Chris J.

    2009-11-01

    The authors unintentionally omitted to mention work [1] that pre-dated the cited work by Haesselbarth and Bremser [2]. This work formulated the problem within a mathematical framework and had been cited by the authors in a previous publication [3]. The major conclusion of the authors' work goes beyond the mathematics presented in [1] and [2] because it is applied to several real data sets and the results are interpreted in practical terms. References [1] Haesselbarth W and Bremser W 2001 Correlation in natural gas composition data Proc. Int. Gas Research Conf. (Amsterdam) [2] Haesselbarth W and Bremser W 2007 Metrologia 44 128-45 [3] Brown A S, Milton M J T, Cowper C J, Squire G D, Bremser W and Branch R W 2004 J. Chromatogr. A 1040 215-25

  15. High energy neutrinos from astrophysical accelerators of cosmic ray nuclei

    NASA Astrophysics Data System (ADS)

    Anchordoqui, Luis A.; Hooper, Dan; Sarkar, Subir; Taylor, Andrew M.

    2008-02-01

    Ongoing experimental efforts to detect cosmic sources of high energy neutrinos are guided by the expectation that astrophysical accelerators of cosmic ray protons would also generate neutrinos through interactions with ambient matter and/or photons. However, there will be a reduction in the predicted neutrino flux if cosmic ray sources accelerate not only protons but also significant numbers of heavier nuclei, as is indicated by recent air shower data. We consider plausible extragalactic sources such as active galactic nuclei, gamma ray bursts and starburst galaxies and demand consistency with the observed cosmic ray composition and energy spectrum at Earth after allowing for propagation through intergalactic radiation fields. This allows us to calculate the expected neutrino fluxes from the sources, normalized to the observed cosmic ray spectrum. We find that the likely signals are still within reach of next generation neutrino telescopes such as IceCube.PACS95.85.Ry98.70.Rz98.54.Cm98.54.EpReferencesFor a review, see:F.HalzenD.HooperRep. Prog. Phys.6520021025A.AchterbergIceCube CollaborationPhys. Rev. Lett.972006221101A.AchterbergIceCube CollaborationAstropart. Phys.262006282arXiv:astro-ph/0611063arXiv:astro-ph/0702265V.NiessANTARES CollaborationAIP Conf. Proc.8672006217I.KravchenkoPhys. Rev. D732006082002S.W.BarwickANITA CollaborationPhys. Rev. Lett.962006171101V.Van ElewyckPierre Auger CollaborationAIP Conf. Proc.8092006187For a survey of possible sources and event rates in km3 detectors see e.g.,W.BednarekG.F.BurgioT.MontaruliNew Astron. Rev.4920051M.D.KistlerJ.F.BeacomPhys. Rev. D742006063007A. Kappes, J. Hinton, C. Stegmann, F.A. Aharonian, arXiv:astro-ph/0607286.A.LevinsonE.WaxmanPhys. Rev. Lett.872001171101C.DistefanoD.GuettaE.WaxmanA.LevinsonAstrophys. J.5752002378F.A.AharonianL.A.AnchordoquiD.KhangulyanT.MontaruliJ. Phys. Conf. Ser.392006408J.Alvarez-MunizF.HalzenAstrophys. J.5762002L33F.VissaniAstropart. Phys.262006310F.W

  16. Production of highly charged ions with an ECRIS using high temperature super-conducting coils

    NASA Astrophysics Data System (ADS)

    Bieth, C.; Kantas, S.; Sortais, P.; Kanjilal, D.; Rodrigues, G.; Milward, S.; Harrison, S.; Mc Mahon, R.

    2005-07-01

    Highly charged ions are widely used in atomic physics, nuclear physics and material science. One requirement to produce highly charged ions for an ECRIS [P. Sortais et al., ECRIS development at GANIL, in: Proceedings of the 12th Int. Conf. on Cyclotrons, Berlin, 1989; P. Sortais et al., in: Proceedings of the Int. Conf. on Ion sources, Berkley 1989, p. 288] is a high resonance frequency, hence a high resonance magnetic field. With electromagnets, we can produce limited magnetic fields, generally, in the range of 2 T. Also, electromagnets require a significant amount of electrical power, powerful DC power supplies and large cooling systems. As a consequence, producing highly charged ions with a source setup, at ground, is rather difficult and becomes a serious technical and financial challenge if the source is on a high voltage terminal. The use of low temperature superconducting coils 'LTC' has a real advantage when it comes to electrical power. A reduction factor of 10-20 in the total AC power is obtained. However, the handling of cryogenic liquids generates difficulties and extra costs. An elegant solution consists in using high temperature superconducting wire 'HTS' [Y.L. Tang et al., Super Cond. Sci. Technol. 15 (2002); L. Masure et al., 2002, in: ISS2002 Conf. Proc. (Yokohama, Japan, November 2002) in press]. Indeed, the superconductivity of the HTS wire starts at 77 K. Cryogenic generators with sufficient cooling power at 20 K are commercially available and need only few kW of AC power. In addition to that, the coils are very compact and easy to handle. The following paper presents PKDELIS [ECR HTS source using superconducting coils, French Patent No. FR98 06579]. The first ECRIS in the world using HTS wires, jointly designed and constructed by PANTECHNIK and NSC New Delhi, India.

  17. Negative Ion Crystal Formation in Nonequilibrium Dusty Plasma at a Gas Evacuation from Technological Devices for Vacuum Support

    NASA Astrophysics Data System (ADS)

    Azarenkov, Nikolai A.; Egorov, Alexei M.; Maslov, Vasyl I.; Onishchenko, Ivan N.; Frolova, Darya Yu.

    2002-11-01

    Plasma crystal formation (or so called ion crystal formation) are investigated now intensively (see, for example, [1-5]). In particular, the formation of the plasma crystals has been observed in experiments at providing of nonequilibrium state. If in equilibrium dusty plasma there was no plasma crystal but at providing of nonequilibrium state at a gas evacuation from devices for vacuum support in a dusty plasma in experiment an ion crystal has been formed. In this case at gas evacuation the plasma flow has been appeared due to gradient of the pressure. The flow excites the perturbations of large amplitudes. The generalised equation is derived for the spatial distribution of field of any amplitude. It is shown that these perturbations of large amplitude lead to spatial ordering of heavy negative ions. It is shown that the crystal is almost motionless, because heavy negative ions are trapped by chain of perturbations formed due to instability development on generalised dusty-ion-acoustic mode with velocity equal almost zero. 1.H.M.Thomas, G.E. Morfill. Nature. 379 (1996) 806. 2.R.K.Varma, P.K.Shukla. Physica Scripta. 51 (1995) 522. 3.M.Nambu, S.V.Vladimirov, P.K.Shukla. Phys. Lett. A. 203 (1995) 40. 4.A.Melzer, A.Piel et al. Proc. Int. Top. Conf. on Plasma Physics. Trieste. Italy. 2000. 5.V.E.Fortov, A.P.Nefedov et al. Proc. Int. Conf. on Plasma Physics. Trieste. Italy. 2000. 6.D.A.Law, B.M.Annaratone, J.E.Allen et al. Dust Particle Interaction in RF Plasma Sheaths.

  18. Rebuttal to the comment by Malhotra and Strom on "Constraints on the source of lunar cataclysm impactors"

    NASA Astrophysics Data System (ADS)

    Ćuk, Matija; Gladman, Brett J.; Stewart, Sarah T.

    2011-11-01

    Ćuk et al. (Ćuk, M. Gladman, B.J., Stewart, S.T. [2010]. Icarus 207 590-594) concluded that the the lunar cataclysm (late heavy bombardment) was recorded in lunar Imbrian era craters, and that their size distribution is different from that of main belt asteroids (which may have been the dominant pre-Imbrian impactors). This result would likely preclude the asteroid belt as the direct source of lunar cataclysm impactors. Malhotra and Strom (Malhotra, R., Strom, R.G. [2011]. Icarus) maintain that the lunar impactor population in the Imbrian era was the same as in Nectarian and pre-Nectarian periods, and this population had a size distribution identical to that of main belt asteroids. In support of this claim, they present an Imbrian size distribution made from two data sets published by Wilhelms et al. (Wilhelms, D.E., Oberbeck, V.R., Aggarwal, H.R. [1978]. Proc. Lunar Sci. Conf. 9, 3735-3762). However, these two data sets cannot be simply combined as they represent areas of different ages and therefore crater densities. Malhotra and Strom (Malhotra, R., Strom, R.G. [2011]. Icarus) differ with the main conclusion of Wilhelms et al. (Wilhelms, D.E., Oberbeck, V.R., Aggarwal, H.R. [1978]. Proc. Lunar Sci. Conf. 9, 3735-3762) that the Nectarian and Imbrian crater size distributions were different. We conclude that the available data indicate that the lunar Imbrian-era impactors had a different size distribution from the older ones, with the Imbrian impactor distribution being significantly richer in small impactors than that of older lunar impactors or current main-belt asteroids.

  19. The development and application of a simplified ozone modeling system (SOMS)

    NASA Astrophysics Data System (ADS)

    Venkatram, Akula; Karamchandani, Prakash; Pai, Prasad; Goldstein, Robert

    This paper describes the development and evaluation of a computationally efficient semi-empirical photochemical model that can be used as a screening tool to obtain quick estimates of the effect of a large number of VOC and NO x emission control strategies on ozone concentrations. Selected control strategies can subsequently be examined with a more complex model. The model is one component of an ozone management system, the regional ozone decision model (RODM), designed to examine the costs and environmental consequences of alternate ozone abatement strategies. The model was developed by systematic simplification of a detailed photochemical model. At each step of the simplification, the simplified model was tested against observations and against results from the detailed model. The first major simplification was the introduction of a highly parameterized chemistry mechanism, originally developed by Azzi et al. (1992 Proc. 11th Int. Clean Air Conf., 4th Regional IUAPPA Conf.). This modification resulted in a factor of 5 improvement in the computational efficiency of the model. The model with the simplified chemistry was then tested by applying it to a photochemical oxidant episode in the San Joaquin Valley of California. Further improvements in computational speed and efficiency were obtained by uncoupling the chemistry from the transport of VOC and NO x.

  20. 77 FR 18283 - Self-Regulatory Organizations; The National Securities Clearing Corporation; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... Alternative Investment Product Services To Standardize and Automate the Method by Which Registered AIP Broker... its Alternative Investment Product Services (``AIP''). The proposed rule change is intended to... investment product (collectively ``AIP Manufacturers'') as a ``good control location,'' as more...

  1. Graduate Student Report: First-Year Physics and Astronomy Students in 2002 and 2003. AIP Report, Number R-207.34

    ERIC Educational Resources Information Center

    McFarling, Mark; Neuschatz, Michael; Mulvey, Patrick J.

    2004-01-01

    The American Institute of Physics has regularly reported information about physics and astronomy graduate students since 1968. In more recent years the survey has shifted to focus on first-year graduate students, with a survey of the full population of graduate students every few years. This report covers surveys of first-year students for the…

  2. Does It Matter Where I Go to College? Effects of Physics Departments on Student Outcomes. AIP Report, Number R-433.03

    ERIC Educational Resources Information Center

    Ivie, Rachel; Nies, Kim

    2004-01-01

    The decision about which college to attend can be daunting. College bound high school students may pore over catalogs, make visits to multiple campuses, and negotiate the intricacies of financial aid. There are a variety of choices, and the most basic of choices involves what type of school to attend. Should it be a well-funded research university…

  3. Reaching the Critical Mass: The Twenty Year Surge in High School Physics. Findings from the 2005 Nationwide Survey of High School Physics Teachers. AIP Report. Number R-442

    ERIC Educational Resources Information Center

    Neuschatz, Michael; McFarling, Mark; White, Susan

    2008-01-01

    This report traces the growth of high school physics in American school over the past twenty years. Highlights of the report include: (1) Enrollments in high school physics continue to grow; (2) Increase in number and proportion of physics teachers; (3) Number of students taking honors, advance placement or second-year physics course has nearly…

  4. Enhanced affordable methods for assessing material characteristics and consolidation effects on stone and mortar

    NASA Astrophysics Data System (ADS)

    Drdácký, Miloš; Slížková, Zuzana

    2013-12-01

    It is rather difficult to set up non-destructive or considerate in situ tests for assessing material characteristics and consolidation effects on historic stone and mortar. However, some simple methods have proved to be helpful when applied appropriately and this paper provides brief information about two such methods: peeling tests, also known as the ‘Scotch tape’ method, and surface water uptake measurements using a digitized microtube. Both methods have some history of development and use Mora and Torraca (1965 Bollettino Istituto Centrale del Restauro (Rome) pp 109-32), Giorgi et al (2000 Stud. Conserv. 45 154-61), Tiano et al (2006 J. Cult. Heritage 7 49-55), Lehmann (2004 Thesis, Hochschule für Bildende Künste, Dresden pp 33-34), Drdácký et al (2011 Proc. European Workshop on Cultural Heritage Preservation pp 126-30) and Zíma (2011 Proc. 49th Int. Scientific Conf. on Experimental Stress Analysis pp 441-8) without any standardized support. This lack of a validated procedure can lead to some deficiencies and misinterpretations for applying the peeling test. Also, in the case of the digitized micro-tube, there can be some difficulties when the device is applied, which could prevent its wider adoption or even lead to rejection of the micro-tube technique. The paper summarizes basic principles for the application of both methods and reports illustrative results for laboratory and historic building investigations.

  5. Fuzzy Subspace Clustering

    NASA Astrophysics Data System (ADS)

    Borgelt, Christian

    In clustering we often face the situation that only a subset of the available attributes is relevant for forming clusters, even though this may not be known beforehand. In such cases it is desirable to have a clustering algorithm that automatically weights attributes or even selects a proper subset. In this paper I study such an approach for fuzzy clustering, which is based on the idea to transfer an alternative to the fuzzifier (Klawonn and Höppner, What is fuzzy about fuzzy clustering? Understanding and improving the concept of the fuzzifier, In: Proc. 5th Int. Symp. on Intelligent Data Analysis, 254-264, Springer, Berlin, 2003) to attribute weighting fuzzy clustering (Keller and Klawonn, Int J Uncertain Fuzziness Knowl Based Syst 8:735-746, 2000). In addition, by reformulating Gustafson-Kessel fuzzy clustering, a scheme for weighting and selecting principal axes can be obtained. While in Borgelt (Feature weighting and feature selection in fuzzy clustering, In: Proc. 17th IEEE Int. Conf. on Fuzzy Systems, IEEE Press, Piscataway, NJ, 2008) I already presented such an approach for a global selection of attributes and principal axes, this paper extends it to a cluster-specific selection, thus arriving at a fuzzy subspace clustering algorithm (Parsons, Haque, and Liu, 2004).

  6. 78 FR 79036 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... investment products eligible for processing through the Alternative Investment Product Services (``AIP'') of NSCC, as well as to eliminate the fee cap currently applicable to AIP Distributors \\5\\ processing Registered Hedge Fund transactions through AIP. In general, AIP fees are grouped by volume-- higher...

  7. Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience

    PubMed Central

    Buechter, Matthias; Manka, Paul; Heinemann, Falko Markus; Lindemann, Monika; Juntermanns, Benjamin; Canbay, Ali; Gerken, Guido

    2017-01-01

    Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of patients suffered from AIP1 (55.6%). AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years). Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC). However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4). When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance. Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients. Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC). Conclusion. In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort. AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis. PMID:28348580

  8. Fast wave power flow along SOL field lines in NSTX

    NASA Astrophysics Data System (ADS)

    Perkins, R. J.; Bell, R. E.; Diallo, A.; Gerhardt, S.; Hosea, J. C.; Jaworski, M. A.; Leblanc, B. P.; Kramer, G. J.; Phillips, C. K.; Roquemore, L.; Taylor, G.; Wilson, J. R.; Ahn, J.-W.; Gray, T. K.; Green, D. L.; McLean, A.; Maingi, R.; Ryan, P. M.; Jaeger, E. F.; Sabbagh, S.

    2012-10-01

    On NSTX, a major loss of high-harmonic fast wave (HHFW) power can occur along open field lines passing in front of the antenna over the width of the scrape-off layer (SOL). Up to 60% of the RF power can be lost and at least partially deposited in bright spirals on the divertor floor and ceiling [1,2]. The flow of HHFW power from the antenna region to the divertor is mostly aligned along the SOL magnetic field [3], which explains the pattern of heat deposition as measured with infrared (IR) cameras. By tracing field lines from the divertor back to the midplane, the IR data can be used to estimate the profile of HHFW power coupled to SOL field lines. We hypothesize that surface waves are being excited in the SOL, and these results should benchmark advanced simulations of the RF power deposition in the SOL (e.g., [4]). Minimizing this loss is critical optimal high-power long-pulse ICRF heating on ITER while guarding against excessive divertor erosion.[4pt] [1] J.C. Hosea et al., AIP Conf Proceedings 1187 (2009) 105. [0pt] [2] G. Taylor et al., Phys. Plasmas 17 (2010) 056114. [0pt] [3] R.J. Perkins et al., to appear in Phys. Rev. Lett. [0pt] [4] D.L. Green et al., Phys. Rev. Lett. 107 (2011) 145001.

  9. MONTE-CARLO Simulations ``QUANTUM''-``NOISE'' POWER-SPECTRUM 0 =(F =ma) =0 Uniform-Velocity Pareto/Red/Beethoven-Law VS 0 ≠(F =ma) ≠0 Uniform-Acceleration/Deceleration/Bremsstrahlung Archimedes-(Euclid-Descartes)-Zipf/Pink/Flicker/Bach-Law UNIVERSALITY INEVITABILITY!!!

    NASA Astrophysics Data System (ADS)

    Louis, T. T. L.; Siegel, Edward Carl-Ludwig; Young, Frederic; Smith, Adolph

    2013-03-01

    Dynamics vs usual by-rote kinematics treatment/lack of understanding, via Siegel[AIP Shock-Physics Confs. Chicago(2011); Seattle(2013)] simple classical-mechanics/dynamics simple-insights]-Panofsky-Phillips[E&M (1960s)],of Monte Carlo[Kaplan et.al.[PRL 107, 201601 (11)]:'''Noise', Sign-Problems & Statistics'']-simulations' {Hamersley-Handscombe, Monte Carlo Methods, Methuen(64-75)}``noises'' power-spectra{SEMINAL Montroll [(60s-80s)}-Boccara[ ``Modeling'' ``Complex''-Sys.(02)-ch.-8/p.-311]-West et.al.[Physics of Fractal-Operators, Springer(00)]-Shlesinger-Lindenberg-Handel-van Vliet-Jonscher-Ngai-...-Siegel[Schrodinger Symp., Imperial-College (1987);Copenhagen-Onterp. 50-Yrs. After Como-Lect.,Symp.Fdns.Mod.Phys., Joensu(87)]}, in the light of Siegel[MRS Fall-Mtgs. Boston: Symp. Fractals(89)-5-papers!!!; Symp. Scaling(90); Symp.Transport in Geometric-Constraints(90)] power-law decay algebraicity vs. white/flat/functionless [analogous to Fokker-Planck-eqn. two-terms Dichotomy, relatively: static/non-diffusive vs diffusive!!!] but dimensionality-dependence: first-odd-integer Z vs. first-even-integer Z: 2-D bulk-region -area - dominated constant

  10. Analyses par diffraction de rayons X sur des revêtements barrières thermiques réalisés par un procédé hybride plasma-laser

    NASA Astrophysics Data System (ADS)

    Antou, G.; Hlawka, F.; Montavon, G.; Bach, M.; Cornet, A.; Coddet, C.

    2004-11-01

    Les revêtements barrières thermiques (BTs) constitués de zircone yttriée partiellement stabilisée (ZrO{2} + 7% en masse d'Y{2}O{3}) et d'une sous-couche métallique (MCrAlY où M représente une combinaison de nickel et de cobalt) sont extrêmement utilisés afin d'améliorer les performances des composants des parties chaudes des turbines à gaz. La projection plasma sous atmosphère ambiante et l'irradiation laser in situ (au moyen d'un laser à diodes) sont associés ici afin de modifier les caractéristiques structurales des BTs. Les phases présentes au sein de la BT ont un rôle important. Des analyses par diffraction de rayons X ont été menées pour étudier les changements de phase possibles après traitement laser. Aucun changement de phase n'a été remarqué : la phase tétragonale métastable (t') demeure la phase prépondérante aussi bien pour les dépôts projetés que les dépôts post-traités au laser et refondus in situ. La formation de cette phase semble être liée à la solidification et au refroidissement rapide découlant de la projection plasma ainsi que de la refusion laser. Ce résultat est prometteur, car :

  11. Amélioration des performances du procédé de soudage TIG sur un acier au carbone et un alliage d'aluminium par dépôt de silice

    NASA Astrophysics Data System (ADS)

    Sire, Stéphane; Marya, Surendar

    This Note presents ways to improve the weld penetration potential of TIG process by optimising silica application around the joints in a plain carbon steel and an aluminium alloy 5086. Whereas for plain carbon steels, full coverage of joint improves penetration, the presence of a blank zone around the joint in the flux coating on aluminium 5086 using AC-TIG seems to be the best solution for cosmetic and deep welds. To cite this article: S. Sire, S. Marya, C. R. Mecanique 330 (2002) 83-89.

  12. Inroads into base excision repair II. The discovery of DNA glycosylases. "An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues," Proc. Nat. Acad. Sci. USA, 1974.

    PubMed

    Friedberg, Errol C; Lindahl, Tomas

    2004-11-02

    The discovery of a DNA glycosylase that specifically removes uracil from DNA, opened the door for uncovering a large class of such enzymes that are fundamental to the process of base excision repair of DNA.

  13. Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules. Proc. Natl. Acad. Sci. USA. 1991. 88: 3150-3154.

    PubMed

    Roche, Paul A; Cresswell, Peter

    2011-08-01

    HLA-DR molecules are heterodimeric transmembrane glycoproteins that associate intracellularly with a polypeptide known as the invariant (I) chain. Shortly before expression of the HLA-DR αβ dimer on the cell surface, however the I chain is removed from the intracellular αβI complex by a mechanism thought to involve proteolysis . In this report, we show that treatment of purified αβI with the cysteine proteinase cathepsin B results in the specific proteolysis of the HLA-DR-associated I chain in vitro. As a consequence of this, the I chain is removed and free αβ dimers are released from αβI. Although αβI fails to bind an immunogenic peptide, the released αβ dimers acquire the ability to bind the peptide after proteolysis of the I chain. These results suggest that the I chain inhibits immunogenic peptide binding to αβI early during intracellular transport and demonstrate that proteolysis is likely to be the in vivo mechanism of I chain removal.

  14. LRO Diviner Radiometer and the Apollo 15 Heat Flow Experiment

    NASA Astrophysics Data System (ADS)

    Siegler, M. A.; Keihm, S. J.; Paige, D. A.; Vasavada, A. R.; Ghent, R. R.; Bandfield, J. L.; Snook, K.

    2009-12-01

    (Saito et al 2007, 2008). Shallow Apollo data show clear signs of shunting of heat down the borestem of the thermal probe at the onset of the lunation cycle, requiring 2 or 3D models. The thermal probe also showed a long term drift postulated to be caused by either alteration of surface conditions by the Apollo astronauts (Langseth et al 1976) or the 18.6 year component of the lunar orbit (Saito 2008). An overarching explanation of these inconsistencies should bolster confidence in an Apollo based thermal model and heat flow results as well as provide a base for modeling diffusive movement of volatiles through the near surface regolith in polar environments. [1] Keihm S. and Langseth (1975) Icarus 24, 211. [2] Keihm (1984) Icarus 60, 568. [3] Langseth, M. G. et al. (1976) Proc. Lunar Sci. Conf., 7th, 3143. [4] Courtesy Rosiek M., USGS Astrogeology Science Center, http://astrogeology.usgs.gov [5] Saito, Y. (2007) Proc. 38th Lunar Planet. Sci. Conf., 2197. [6] Saito, Y. (2008) Proc. 39th Lunar Planet. Sci. Conf., 1663. [7] Vasavada A. et al (1999) Icarus 141, 179.

  15. Volume Recombination in Alcator C-Mod Divertor Plasmas

    NASA Astrophysics Data System (ADS)

    Terry, J. L.

    1997-11-01

    Volume recombination has been predicted(See, for example, A. Loarte, Proc. 12th PSI Conf, J. Nucl. Mater (1996) I9, in press.) to be a significant sink for plasma ions under the detached divertor conditions achieved on many tokamaks. This volume recombination sink was observed initially in Alcator C-Mod and shown to be a major fraction of the ion loss. Signatures of recombination have now been observed on DIII-D(R.C. Isler, et al., paper submitted for publication), Asdex-UG (B. Napiontek, et al. 24th EPS Conf., Berchtesgaden, Germany, 1997, P4.007, in press.), and JET(R.D. Monk, et al. 24th EPS Conf., Berchtesgaden, Germany, 1997, P1.030, in press.). It is important primarily because the recombined atoms are not accelerated through the sheath - thus reducing divertor plate sputtering, and because most of the potential energy of recombination (13.6 eV) is released as radiation before the ion strikes the plate. The Alcator C-Mod measurements show that the recombination occurs in low Te ( ~1 eV), high ne ( ~1× 10^21 m-3) regions, and is significantly larger in detached regions. At the inboard, detached divertor plate the measured volume recombination rate is typically greater than the rate of ion collection at that plate and is about an order of magnitude higher than on the attached, outer plate. These spatially resolved measurements also show that the recombination rate is peaked near the strike point and imply that the recombination is occurring close to the plate surface. The C-Mod observations about the magnitude and spatial distribution of the recombination are consistent with the modelling of similar discharges(F. Wising et al., Contrib. Plasma Phys. 36, p 136 (1996).). The experimental evidence for recombination is found in the deuterium emission spectra from the divertor, in particular in the Balmer- and/or Lyman-series. The spectra show that the dominant recombination mechanism is 3-body recombination into excited states of deuterium and that the populations

  16. Physics of Spherical Torus Plasmas

    SciTech Connect

    Peng, Yueng Kay Martin

    2000-01-01

    Broad and important progress in plasma tests, theory, new experiments, and future visions of the spherical torus (ST, or very low aspect ratio tokamaks) have recently emerged. These have substantially improved our understanding of the potential properties of the ST plasmas, since the preliminary calculation of the ST magnetohydrodynamic equilibria more than a decade ago. Exciting data have been obtained from concept exploration level ST experiments of modest capabilities (with major radii up to 35 cm), making important scientific contributions to toroidal confinement in general. The results have helped approval and construction of new and/or more powerful ST experiments, and stimulated an increasing number of theoretical calculations of interest to magnetic fusion energy. Utilizing the broad knowledge base from the successful tokamak and advanced tokamak research, a wide range of new ST physics features has been suggested. These properties of the ST plasma will be tested at the 1 MA level with major radius up to similar to 80 cm in the new proof of principle devices National Spherical Torus Experiment (NSTX, U.S.) [M. Peng , European Conf. Abst. 22C, 451 (1998); S. M. Kaye , Fusion Technol. 36, 16 (1999); M. Ono , "Exploration of Spherical Torus Physics in the NSTX Device," 17th IAEA Fusion Energy Conf., paper IAEA-CN-69/ICP/01 (R), Yokohama, Japan (1998)], Mega Ampere Spherical Tokamak (MAST, U.K.) [A. C. Darke , Fusion Technol. 1, 799 (1995); Q. W. Morris , Proc. Int. Workshop on ST (Ioffe Inst., St. Petersburg, 1997), Vol. 1, p. 290], and Globus-M (R.F.) [V. K. Gusev , European Conf. Abst. 22C, 576 (1998)], which have just started full experimental operation. New concept exploration experiments, such as Pegasus (University of Wisconsin) [R. Fonck and the PEGASUS Team, Bull. Am. Phys. Soc. 44, 267 (1999)], Helicity Injected Tokamak-II (HIT-II, University of Washington) [T. R. Jarboe , Phys. Plasmas 5, 1807 (1998)], and Current Drive Experiment-Upgrade (CDX

  17. Searching for Indigenous Noble Gases in the Moon: Vacuum Crushing of Vesicular Basalt 15016 and Stepwise Heating of Anorthosites 60025, 60215 and 65315 Aliquots

    NASA Astrophysics Data System (ADS)

    Bekaert, D. V.; Avice, G.; Marty, B.; Gudipati, M. S.; Henderson, B. L.

    2015-12-01

    theses samples and primordial U-Xe [4], inferred on theoretical ground to be the precursor of atmospheric Xe but never clearly identified. [1] Lightner and Marti (1974) Proc. Lunar Sci. Conf. 5th, [2] Niemeyer and Leich (1976) Proc. Lunar Sci. Conf. 7th, [3] Niedermann and Eugster (1992) Geochim. Cosmochim. Acta, [4] Pepin (2000) Space Sci. Rev.

  18. Advanced information processing system for advanced launch system: Hardware technology survey and projections

    NASA Technical Reports Server (NTRS)

    Cole, Richard

    1991-01-01

    The major goals of this effort are as follows: (1) to examine technology insertion options to optimize Advanced Information Processing System (AIPS) performance in the Advanced Launch System (ALS) environment; (2) to examine the AIPS concepts to ensure that valuable new technologies are not excluded from the AIPS/ALS implementations; (3) to examine advanced microprocessors applicable to AIPS/ALS, (4) to examine radiation hardening technologies applicable to AIPS/ALS; (5) to reach conclusions on AIPS hardware building blocks implementation technologies; and (6) reach conclusions on appropriate architectural improvements. The hardware building blocks are the Fault-Tolerant Processor, the Input/Output Sequencers (IOS), and the Intercomputer Interface Sequencers (ICIS).

  19. A large format membrane-based x-ray mask for microfluidic chip fabrication

    NASA Astrophysics Data System (ADS)

    Wang, Lin; Zhang, Min; Desta, Yohannes; Melzak, J.; Wu, C. H.; Peng, Zhengchun

    2006-02-01

    X-ray lithography is a very good option for the fabrication of micro-devices especially when high aspect ratio patterns are required. Membrane-based x-ray masks are commonly used for high-resolution x-ray lithography. A thin layer of silicon nitride (Si3N4) or silicon carbide (SiC) film (1-2 µm) is normally used as the membrane material for x-ray mask fabrication (Wells G M, Reilly M, Nachman R, Cerrina F, El-Khakani M A and Chaker M 1993 Mater. Res. Soc. Conf. Proc. 306 81-9 Shoki T, Nagasawa H, Kosuga H, Yamaguchi Y, Annaka N, Amemiya I and Nagarekawa O 1993 SPIE Proc. 1924 450-6). The freestanding membrane window of an x-ray mask, which defines the exposing area of the x-ray mask, can be obtained by etching a pre-defined area on a silicon wafer from the backside (Wang L, Desta Y, Fettig R K, Goettert J, Hein H, Jakobs P and Chulz J 2004 J. Micromech. Microeng. 14 722-6). Usually, the window size of an x-ray mask is around 20 × 20 mm because of the low tensile stress of the membrane (10-100 MPa), and the larger window dimension of an x-ray mask may cause the deformation of membranes and lower the mask quality. However, x-ray masks with larger windows are preferred for micro-device fabrication in order to increase the productivity. We analyzed the factors which influence the flatness of large format x-ray masks and fabricated x-ray masks with a window size of 55 × 55 mm and 46 × 65 mm on 1 µm thick membranes by increasing the tensile stress of the membranes (>300 MPa) and optimizing the stress of the absorber layer. The large format x-ray mask was successfully applied for the fabrication of microfluidic chips.

  20. Erratum: “Effect of hydrothermal condition on the formation of multi-component oxides of Ni-based metallic glass under high temperature water near the critical point” [AIP Advances 5, 077132 (2015)

    DOE PAGES

    Kim, J. S.; Kim, S. Y.; Kim, D. H.; ...

    2015-12-30

    In the original manuscript, M. H. Lee’s affiliation number was incorrectly listed as 1. M. H. Lee’s correct affiliation number is 2 (Rare Metals R&D Group, Korea Institute of Industrial Technology, Incheon 406-840, South Korea). Furthermore, this change affects no other part of the paper.

  1. Calculating video meteor positions in a narrow-angle field with AIP4Win software - Comparison with the positions obtained by SPOSH cameras in a wide-angle field

    NASA Astrophysics Data System (ADS)

    Tsamis, Vagelis; Margonis, Anastasios; Christou, Apostolos

    2013-01-01

    We present an alternative way to calculate the positions of meteors captured in a narrow video field with a Watec camera and a 28 mm aspherical lens (FOV 11 degrees) by using Astronomical Image Processing for Windows, V2, a classic astrometry and photometry software. We have calculated positions for two Perseid meteors in Lyra which were recorded in August 2010, at Mt. Parnon, Greece. We then compare our astrometry position results with the results obtained by SPOSH cameras (FOV 120 degrees) for the same meteors.

  2. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... project title, PFC funds sought, PFC level sought, and, if an existing Airport Improvement Program (AIP) grant already covers this project, the grant agreement number. (3) If an existing AIP grant does...

  3. 78 FR 71024 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... specified by the Airport Improvement Program (AIP), and 49 U.S.C. part A, Air Commerce Safety, and part B... eligible for AIP funds and for calculating primary airport sponsor apportionment as specified by Title 49...

  4. 49 CFR Appendix A to Part 23 - Uniform Report of ACDBE Participation

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... financial assistance and AIP number. 2. Provide the name and contact information (phone, fax, e-mail) for... to this item. Uniform Report of ACDBE Participation 1. Name of Recipient and AIP Number: 2....

  5. 49 CFR Appendix A to Part 23 - Uniform Report of ACDBE Participation

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... financial assistance and AIP number. 2. Provide the name and contact information (phone, fax, e-mail) for... to this item. Uniform Report of ACDBE Participation 1. Name of Recipient and AIP Number: 2....

  6. 26 CFR 1.1275-7 - Inflation-indexed debt instruments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...: OID((n) = AIP(n) × in which, r = yield of the debt instrument as determined under paragraph (e)(3)(i...; and AIP(n) = adjusted issue price at the beginning of period (n). (v) Step five: Determine the...

  7. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... project title, PFC funds sought, PFC level sought, and, if an existing Airport Improvement Program (AIP) grant already covers this project, the grant agreement number. (3) If an existing AIP grant does...

  8. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... project title, PFC funds sought, PFC level sought, and, if an existing Airport Improvement Program (AIP) grant already covers this project, the grant agreement number. (3) If an existing AIP grant does...

  9. Multicolor, time-gated, soft x-ray pinhole imaging of wire array and gas puff Z pinches on the Z and Saturn pulsed power generators.

    PubMed

    Jones, B; Coverdale, C A; Nielsen, D S; Jones, M C; Deeney, C; Serrano, J D; Nielsen-Weber, L B; Meyer, C J; Apruzese, J P; Clark, R W; Coleman, P L

    2008-10-01

    A multicolor, time-gated, soft x-ray pinhole imaging instrument is fielded as part of the core diagnostic set on the 25 MA Z machine [M. E. Savage et al., in Proceedings of the Pulsed Power Plasma Sciences Conference (IEEE, New York, 2007), p. 979] for studying intense wire array and gas puff Z-pinch soft x-ray sources. Pinhole images are reflected from a planar multilayer mirror, passing 277 eV photons with <10 eV bandwidth. An adjacent pinhole camera uses filtration alone to view 1-10 keV photons simultaneously. Overlaying these data provides composite images that contain both spectral as well as spatial information, allowing for the study of radiation production in dense Z-pinch plasmas. Cu wire arrays at 20 MA on Z show the implosion of a colder cloud of material onto a hot dense core where K-shell photons are excited. A 528 eV imaging configuration has been developed on the 8 MA Saturn generator [R. B. Spielman et al., and A. I. P. Conf, Proc. 195, 3 (1989)] for imaging a bright Li-like Ar L-shell line. Ar gas puff Z pinches show an intense K-shell emission from a zippering stagnation front with L-shell emission dominating as the plasma cools.

  10. Study on the Feasibility of Direct Fusion Energy Conversion for Deep-Space Propulsion

    NASA Astrophysics Data System (ADS)

    Tarditi, Alfonso G.; Miley, George H.; Scott, John H.

    2012-10-01

    A significant change in the current space mission capabilities can be achieved with a highly efficient integration of a fusion energy source with an advanced space propulsion thruster, both with low specific mass. With aneutronic nuclear fusion as the high-density primary energy source, this study considers first electric energy extraction from the fusion reaction products via direct energy conversion to recirculate power as required for the operation of the fusion core. Then the beam of remaining reaction products is conditioned to achieve the optimal thrust and specific impulse for the mission. The research is specifically focused on two key issues: (i) Efficiency improvement of a Traveling Wave Direct Energy Converter (TWDEC, [1]) by achieving a higher ion beam density and optimization of the electrode coupling and of the neutralizing electron flow. (ii) A fast-particle kinetic energy-to-thrust conversion process based on collective interaction between ion bunches well separated in space [2]. Computer simulation results and a design for a basic physics experiment currently under development are reported. [4pt] [1] H. Momota et al., Fus. Tech., 35, 60(1999)[0pt] [2] A. G. Tarditi et al. Proc. NETS 2012 Conf., Woodlands, TX (2012)

  11. A Modified ART 1 Algorithm more Suitable for VLSI Implementations.

    PubMed

    Linares-Barranco, Bernabe; Serrano-Gotarredona, Teresa

    1996-08-01

    This paper presents a modification to the original ART 1 algorithm ([Carpenter and Grossberg, 1987a], A massively parallel architecture for a self-organizing neural pattern recognition machine, Computer Vision, Graphics, and Image Processing, 37, 54-115) that is conceptually similar, can be implemented in hardware with less sophisticated building blocks, and maintains the computational capabilities of the originally proposed algorithm. This modified ART 1 algorithm (which we will call here ART 1(m)) is the result of hardware motivated simplifications investigated during the design of an actual ART 1 chip [Serrano-Gotarredona et al., 1994, Proc. 1994 IEEE Int. Conf. Neural Networks (Vol. 3, pp. 1912-1916); [Serrano-Gotarredona and Linares-Barranco, 1996], IEEE Trans. VLSI Systems, (in press)]. The purpose of this paper is simply to justify theoretically that the modified algorithm preserves the computational properties of the original one and to study the difference in behavior between the two approaches. Copyright 1996 Elsevier Science Ltd.

  12. Faraday current sensing employing chromatic modulation

    NASA Astrophysics Data System (ADS)

    Jones, G. R.; Li, G.; Spencer, J. W.; Aspey, R. A.; Kong, M. G.

    1998-01-01

    Faraday current sensors using a variety of sensing elements have been investigated extensively for their high sensitivity as well as other advantages [G.L. Lewis et al., Proc. IEE Conf. on The Reliability of Transmission and Distribution Equipment, 1995; Y.N. Ning et al., Optics Lett. 16 (1991); C.M.M. van den Tempel, Appl. Optics 32 (1993)]. Concurrently chromatic modulation techniques have been investigated at the University of Liverpool for use with optical fibre sensors of different types [N.A. Pilling, Ph.D. Thesis, 1992; M.M. Murphy, Ph.D. Thesis, 1991] including Faraday current sensing, for overcoming difficulties with non-referenced intensity modulation systems. In this contribution a brief discussion of the scope of chromatically based Faraday current sensing with particular regard to electric power transmission and distribution industries is given. A novel sensor based upon a Faraday glass block in combination with a BSO crystal in the sensing element is described. The sensor takes advantage of the natural gyrotropy of the BSO which conversely has been previously regarded as a disadvantage. The experimental results obtained indicate that this method offers a novel approach to improving system sensitivity. The extension of the approach from a simple bench top demonstrator to real power systems deployment is also discussed.

  13. MHD Simulation of Plasma Flow through the VASIMR Magnetic Nozzle

    NASA Astrophysics Data System (ADS)

    Tarditi, A. G.; Shebalin, J. V.

    2003-10-01

    The VASIMR (Variable Specific Impulse Magnetoplasma Rocket, [1]) concept is currently in the experimental development phase at the Advanced Space Propulsion Laboratory, NASA Johnson Space Center. The current experimental effort is mainly focused on the demonstration of the efficient plasma production (light ion helicon source, [2]) and energy boosting (ion cyclotron resonance heating section). Two other critical issues, the plasma detachment process and the collimation of the plasma plume in the magnetic nozzle, are essential for the near term experimental development and are being addressed through an MHD simulation modeling effort with the NIMROD code [3,4]. The model follows the plasma flow up to few meters from the nozzle throat: at that distance the plasma exhaust parameters reach values comparable with the ionospheric plasma background [5]. Results from two-dimensional simulation runs (cylindrical geometry, assuming azimuthal symmetry) aimed in particular at testing the effectiveness of different open-end boundary condition schemes are presented. [1] F. R. Chang-Diaz, Scientific American, p. 90, Nov. 2000 [2] M. D. Carter, et al., Phys. Plasmas 9, 5097-5110, 2002 [3] http://www.nimrodteam.org [4] A. Tarditi et al., 28th Int. Electric Propulsion Conf., IEPC 2003, Toulouse, France, March 2003 [5] A. V. Ilin et al., Proc. 40th AIAA Aerospace Sciences Meeting, Reno, NV, Jan. 2002

  14. Geophysics and cosmogony of solar system

    NASA Astrophysics Data System (ADS)

    Kuzjmenko, G. I.; Smirnov, V. A.

    2003-04-01

    The attention to primary importance of geophysics in formation of modern representations about planets of Solar system is inverted. [ Kuzjmenko G.I. Deep Processes in the Earth's Interior. Geophys. J. 2001. Vol. 20, pp 813 -831; Kuzjmenko G.I., Smirnov V.A. Minor Bodys and Cosmogony of a Solar System. CAMMAC 2002. Intern. Conf. September 23 - 29, Vinnitsia, 2002, pp 35 -36]. The analysis rocket given about electromagnetic properties of Solar system has helped utilization Generalized Statistical-Wavemechanical Equations (GSWE), which special case is the quantum equation of Schrödinger. From GSWE the decision not only old problems of Solar system, but also prediction of presence of a belt of small bodies of Kuiper's and features of absent-minded substance in Solar system follows. The modern geophysical data on properties of the Earth with use GSWE result not only in the description of the electromagnetic characteristics of planets, but open existence dark mattery, which properties now are actively studied [Kuzjmenko G.I., Zelinsky I.P. Generalized Statistical-Wavemechanical Equations (GSWE) and its Applications. Proc. of 16-th IMACS World Congress 2000. Lausanne, Switzerland, August 21-25, 2000. CD File 416 -1].

  15. Multi-rogue waves solutions: from the NLS to the KP-I equation

    NASA Astrophysics Data System (ADS)

    Dubard, P.; Matveev, V. B.

    2013-12-01

    Our discovery of multi-rogue wave (MRW) solutions in 2010 completely changed the viewpoint on the links between the theory of rogue waves and integrable systems, and helped explain many phenomena which were never understood before. It is enough to mention the famous Three Sister waves observed in oceans, the creation of a regular approach to studying higher Peregrine breathers, and the new understanding of 2 + 1 dimensional rogue waves via the NLS-KP correspondence. This article continues the study of the MRW solutions of the NLS equation and their links with the KP-I equation started in a previous series of articles (Dubard et al 2010 Eur. Phys. J. 185 247-58, Dubard and Matveev 2011 Natural Hazards Earth Syst. Sci. 11 667-72, Matveev and Dubard 2010 Proc. Int. Conf. FNP-2010 (Novgorod, St Petersburg) pp 100-101, Dubard 2010 PhD Thesis). In particular, it contains a discussion of the large parametric asymptotics of these solutions, which has never been studied before.

  16. Early deterioration of coarse woody debris.

    SciTech Connect

    Tainter, Frank, H.; McMinn, James, W.

    1999-02-16

    Tainter, F.H., and J.W. McMinn. 1999. Early deterioration of coarse woody debris. In: Proc. Tenth Bien. South. Silv. Res. Conf. Shreveport, LA, February 16-18, 1999. Pp. 232-237 Abstract - Coarse woody debris (CWD) is an important structural component of southern forest ecosystems. CWD loading may be affected by different decomposition rates on sites of varying quality. Bolts of red oak and loblolly pine were placed on plots at each of three (hydric, mesic. and xerlc) sites at the Savannah River Site and sampled over a I6-week period. Major changes were in moisture content and nonstructural carbohydrate content (total carbohydrates, reducing sugars, and starch) of sapwood. Early changes in nonstructural carbohydrate levels following placement of the bolts were likely due to reallocation of these materials by sapwood parenchyma cells. These carbohydrates later formed pools increasingly metabolized by bacteria and invading fungi. Most prevalent fungi in sapwood were Ceratocysfis spp. in pine and Hypoxy/on spp. in oak. Although pine sapwood became blue stained and oak sapwood exhibited yellow soft decay with black zone lines, estimators of decay (specific gravity, sodium hydroxide solubility, and holocellulose content) were unchanged during the 16-week study period. A small effect of site was detected for starch content of sapwood of both species. Fungal biomass in sapwood of both species, as measured by ergosterol content, was detectable at week zero, increased somewhat by week three and increased significantly by week 16.

  17. Shear & Compression Plasma Viscosity In Spherical ICF

    NASA Astrophysics Data System (ADS)

    Morse, Richard

    2003-10-01

    In (1) the exceptional viscosity of DT plasmas (Braginskii) was estimated to reduce by orders of magnitude growth rates of the most threatening m=0 modes in liner implosions of cylindrical Z-pinch plasmas that reach a thermonuclear T=10keV. Here in spherical B=0 implosions shear viscosity is estimated, by numerical(2)(implicit in t) & analytic(Chandrasekhar) methods, to reduce similarly the growth of R-T modes in DT plasmas reaching 10keV, where μ ˜5.E4 poise, or higher T. Surface plasma interactions with the confining pusher shell(3) & Knudsen(large mfp) limitation of the viscous effects are discussed. Compression viscosity(Zel'dovich) adds noticeably to irreversible heating(reduced to quadratures) in such systems, esp. with final T>10keV &/or implosion velocities >10E7cm/s. Here double implosions, as suggested in (4), can increase significantly entropy production prior to final implosion &, consequently, heating efficiency. (1)Bull. APS 44-7 Nov99 BP189 (2)McCrory et. al. Nuc.Sci.. 64,163(77) & references (3)Montierth et al., PFB 4(4) Ap92 & references (4)Two Stage Heating Of Theta Pinches, Freidberg & Morse, Proc. '71 Garching Conf. On High β Plasmas

  18. On three explicit difference schemes for fractional diffusion and diffusion-wave equations

    NASA Astrophysics Data System (ADS)

    Quintana Murillo, Joaquín; Bravo Yuste, Santos

    2009-10-01

    Three explicit difference schemes for solving fractional diffusion and fractional diffusion-wave equations are studied. We consider these equations in both the Riemann-Liouville and the Caputo forms. We find that the Gorenflo et al (2000 J. Comput. Appl. Math. 118 175) and the Yuste-Acedo (2005 SIAM J. Numer. Anal. 42 1862) methods when applied to fractional diffusion equations are equivalent when BDF1 coefficients are used to discretize the fractional derivative operators, but that this is not the case for fractional diffusion-wave equations. The accuracy and stability of the three methods are studied. Surprisingly, the third method, that of Ciesielski-Leszczynski (2003 Proc. 15th Conf. on Computer Methods in Mechanics), although closely related to the Gorenflo et al method, is the least accurate, especially for short times. The stability analysis is carried out by means of a procedure close to the standard von Neumann method. We find that the stability bounds of the three methods are the same.

  19. Disruptions generated runaways in the FTU high field tokamak

    NASA Astrophysics Data System (ADS)

    Poli, F. M.; Esposito, B.; Maddaluno, G.; Martin-Solis, J. R.

    2001-10-01

    Disruptions in FTU are usually accompanied by the generation of a strong pulse of photoneutrons (YN 10^12n/s), resulting from photonuclear reactions induced by the bremsstrahlung radiation emitted when runaway electrons (REs) strike the plasma facing components. Measurements of YN during major disruptions on TS [1] showed variations of three orders of magnitude when the toroidal field Bt increases from 1.8T to 3.9T. Similar results were found on JT-60 [2], where no REs are produced for low Bt (<2.2T) and a large YN was measured for higher fields (up to 4T). The range of Bt available in FTU (4T-8T) allows to extend such analysis so that useful predictions can be obtained for operation in next-step high field tokamaks (IGNITOR, ITER). The dependence of YN on Bt is investigated in several FTU disruptions. YN increases with Bt for B_t=4T-6T, while no variation is found for B_t=6T-8T: the role played by ne and Ip on such trend is discussed. [1]P.Joyer,G.Martin,Contr.Fusion and Plasma Heating,Proc.17^thEPS Conf.Amsterdam(1990) [2]R.Yoshino et al.,Nucl.Fus.39 151 (1999)

  20. Nearly axisymmetric hot plasmas in a highly rippled tokamak

    NASA Astrophysics Data System (ADS)

    Bellan, Paul

    2002-11-01

    Tokamak ohmic heating current flowing along toroidally rippled flux surfaces results in a poloidal torque. Since pressure gradients cannot offset torques, the torque drives plasma flows which convect plasma toroidally from ripple necks (high B_pol^2) to ripple bulges (low B_pol^2). Stagnation of the oppositely directed toroidal flows at the ripple bulges thermalizes the directed flow velocity ˜ B_pol/μ_0ρ , giving β _pol ˜1. These flows also convect frozen-in poloidal field lines which accumulate at the bulges enhancing the pinch force there and so reducing the bulge. Thus, a nearly axisymmetric β_pol ˜1 equilibrium is achieved using only a few TF coils. Particles bouncing in step between approaching flows will be Fermi accelerated to form a high energy tail. The ST tokamak magnetic mountain experiment [1] showed that, compared to a 1.8% ripple configuration, a 28% ripple configuration had four times the neutron production, and only a modest degradation of overall confinement; the former is consistent with the notion of Fermi acceleration of particles bouncing between colliding toroidal flows and the latter is consistent with ripple reduction due to toroidal convection of poloidal field lines. [1] W. Stodiek et al, Proc. 4th Intl. Conf. Plasma Phys. and Contr. Nuc. Fusion Res., (Madison, 1971), Vol. 1, p. 465

  1. Large-region acoustic source mapping using a movable array and sparse covariance fitting.

    PubMed

    Zhao, Shengkui; Tuna, Cagdas; Nguyen, Thi Ngoc Tho; Jones, Douglas L

    2017-01-01

    Large-region acoustic source mapping is important for city-scale noise monitoring. Approaches using a single-position measurement scheme to scan large regions using small arrays cannot provide clean acoustic source maps, while deploying large arrays spanning the entire region of interest is prohibitively expensive. A multiple-position measurement scheme is applied to scan large regions at multiple spatial positions using a movable array of small size. Based on the multiple-position measurement scheme, a sparse-constrained multiple-position vectorized covariance matrix fitting approach is presented. In the proposed approach, the overall sample covariance matrix of the incoherent virtual array is first estimated using the multiple-position array data and then vectorized using the Khatri-Rao (KR) product. A linear model is then constructed for fitting the vectorized covariance matrix and a sparse-constrained reconstruction algorithm is proposed for recovering source powers from the model. The user parameter settings are discussed. The proposed approach is tested on a 30 m × 40 m region and a 60 m × 40 m region using simulated and measured data. Much cleaner acoustic source maps and lower sound pressure level errors are obtained compared to the beamforming approaches and the previous sparse approach [Zhao, Tuna, Nguyen, and Jones, Proc. IEEE Intl. Conf. on Acoustics, Speech and Signal Processing (ICASSP) (2016)].

  2. Importance of individual events in temporal networks

    NASA Astrophysics Data System (ADS)

    Takaguchi, Taro; Sato, Nobuo; Yano, Kazuo; Masuda, Naoki

    2012-09-01

    Records of time-stamped social interactions between pairs of individuals (e.g. face-to-face conversations, e-mail exchanges and phone calls) constitute a so-called temporal network. A remarkable difference between temporal networks and conventional static networks is that time-stamped events rather than links are the unit elements generating the collective behavior of nodes. We propose an importance measure for single interaction events. By generalizing the concept of the advance of events proposed by Kossinets et al (2008 Proc. 14th ACM SIGKDD Int. Conf. on Knowledge Discovery and Data Mining p 435), we propose that an event is central when it carries new information about others to the two nodes involved in the event. We find that the proposed measure properly quantifies the importance of events in connecting nodes along time-ordered paths. Because of strong heterogeneity in the importance of events present in real data, a small fraction of highly important events is necessary and sufficient to sustain the connectivity of temporal networks. Nevertheless, in contrast to the behavior of scale-free networks against link removal, this property mainly results from bursty activity patterns and not heterogeneous degree distributions.

  3. EFFECT OF SITE ON BACTERIAL POPULATIONS IN THE SAPWOOD OF COARSE WOODY DEBRIS.

    SciTech Connect

    Porter, Emma, G.,; Waldrop, Thomas, A.; McElreath, Susan, D.; Tainter, Frank, H.

    1998-01-01

    Porter, Emma G., T.A. Waldrop, Susan D. McElreath, and Frank H. Tainter. 1998. Effect of site on bacterial populations in the sapwood of coarse woody debris. Pp. 480-484. In: Proc. 9th Bienn. South. Silv. Res. Conf. T.A. Waldrop (ed). USDA Forest Service, Southern Research Station. Gen. Tech. Rep. SRS-20. Abstract: Coarse woody debris (CWD) is an important structural component of southeastern forest ecosystems, yet little is known about its dynamics in these systems. This project identified bacterial populations associated with CWD and their dynamics across landscape ecosystem classification (LEC) units. Bolts of red oak and loblolly pine were placed on plots at each of three hydric, mesic, and xeric sites at the Savannah River Station. After the controls were processed, samples were taken at four intervals over a 16-week period. Samples were ground within an anaerobe chamber using nonselective media. Aerobic and facultative anaerobic bacteria were identified using the Biolog system and the anaerobes were identified using the API 20A system. Major genera isolated were: Bacillus, Buttiauxella, Cedecea, Enterobacter, Erwinia, Escherichia, Klebsiella, Pantoea, Pseudomonas, Serratia, and Xanthomonas. The mean total isolates were determined by LEC units and sample intervals. Differences occurred between the sample intervals with total isolates of 6.67, 13.33, 10.17, and 9.50 at 3, 6, 10, and 16 weeks, respectively. No significant differences in the numbers of bacteria isolated were found between LEC units.

  4. Phase transition for perfect condensation and instability under the perturbations on jump rates of the zero-range process

    NASA Astrophysics Data System (ADS)

    Jeon, Intae

    2010-06-01

    Let Zesdot(Z1, Z2, ..., Zn) represent the steady state of a zero-range process in which n sites are occupied by m particles, with a jump rate between sites given by g. If m = n (a particle density of 1) and Z*n is the maximum cluster size, perfect condensation occurs if n - Z*n converges to 0 in probability as n tends to infinity. In this paper, we improve the description of the conditions for perfect condensation, first introduced by Jeon et al (2000 Ann. Prob. 28 1162) and Jeon and March (2000 Stochastic Models. Proc. Int. Conf. on Stochastic Models in Honor of Professor Donald A Dawson (Ottawa, Canada, 10-13 June 1998) p 233). Applying the results to a few special cases, we demonstrate the existence of an interesting phase transition and conclude that the maximum cluster size in a zero-range process is unstable with respect to fluctuations in the jump rate, g.

  5. Wire Array Z-pinch Insights for Intense X-ray Power Production

    NASA Astrophysics Data System (ADS)

    Sanford, T. W. L.

    1998-11-01

    The discovery [1] that the use of very large numbers of wires enables high x- ray power to be generated from wire-array z-pinches represents a breakthrough in load design for large pulsed power generators, and has permitted high temperatures to be generated in radiation cavities [2] on Saturn [3] and Z [4]. In this paper, changes in x-ray emission characteristics as a function of wire number, array mass, and load radius, for 20-mm-long aluminum arrays on Saturn that led to these breakthrough hohlraum results, are discussed and compared with a few related emission characteristics of high-wire-number aluminum and tungsten arrays on Z. In this discussion, the detailed measurements made with bolometers, filtered XRDs and PCDs, time resolved filtered x-ray pinhole cameras and crystal spectrometers are given meaning by comparison with one, two, and three dimensional radiation-magnetohydrodynamic code simulations. [1] T. W. L. Sanford, et al., Phys. Rev. Lett. 77, 5063 (1996). [2] M. K. Matzen, Phys. Plasmas 4, 1519 (1997). [3] D. D. Bloomquist, et al., Proc. 6th Int. IEEE Pulsed Power Conf., (1987), p. 310. [4] R. B. Spielman, et al., Phys. Plasmas 5, 2105 (1998).

  6. Electrostatic Confinement of Charged Particle Beams

    NASA Astrophysics Data System (ADS)

    Pacheco, Jose; Weathers, Duncan; Ordonez, Carlos

    2009-04-01

    Many experiments rely on the confinement of charged particles. Examples of these experiments range from fusion studies to antiproton-positron studies for antihydrogen production. Researchers have already developed a variety of techniques for controlling and trapping charged particles. Examples of systems devised for such purposes include electrostatic traps in the form of a cavity [1],[2] or in the form of a storage ring like ELISA [3]. For this project, we are pursuing a different approach [4], which relies on a purely electrostatic environment for ion confinement. This system consists of a periodic electrode configuration of cylindrical symmetry that acts to confine an ion beam in the radial direction. In this manner, it is expected that long particle lifetimes inside the trap will be achieved, and that the system will have an inherent scalability to different ion energy. Results obtained from simulation of the proposed system will be presented and discussed along with a brief overview of the steps taken to develop a laboratory prototype. [1] M. Dahan et al., Rev. Sci. Instr. 69 (1998) 76. [2] H. F. Krause et al., American Institute of Physics. CAARI 16^th Int'l Conf. (2001). [3] S.P. Moller et al., Proc. of the 1997 Particle Accelerator Conference. vol 1. pp 1027-1029. Vancouver, Canada. May 1997. [4] J.R. Correa et al., Nucl. Instr. and Meth. In Phys. Res. B 241 (2005) 909-912.

  7. Numerical analysis of JET discharges with the European Transport Simulator

    NASA Astrophysics Data System (ADS)

    Kalupin, D.; Ivanova-Stanik, I.; Voitsekhovitch, I.; Ferreira, J.; Coster, D.; Alves, L. L.; Aniel, Th.; Artaud, J. F.; Basiuk, V.; Bizarro, Joãs P. S.; Coelho, R.; Czarnecka, A.; Huynh, Ph.; Figueiredo, A.; Garcia, J.; Garzotti, L.; Imbeaux, F.; Köchl, F.; Nave, M. F.; Pereverzev, G.; Sauter, O.; Scott, B. D.; Stankiewicz, R.; Strand, P.; contributors, ITM-TF; Contributors, JET-EFDA

    2013-12-01

    The ‘European Transport Simulator’ (ETS) (Coster et al 2010 IEEE Trans. Plasma Sci. 38 2085-92, Kalupin et al 2011 Proc. 38th EPS Conf. on Plasma Physics (Strasbourg, France, 2011) vol 35G (ECA) P. 4.111) is the new modular package for 1D discharge evolution developed within the EFDA Integrated Tokamak Modelling (ITM) Task Force. It consists of precompiled physics modules combined into a workflow through standardized input/output data structures. Ultimately, the ETS will allow for an entire discharge simulation from the start up until the current termination phase, including controllers and sub-systems. The paper presents the current status of the ETS towards this ultimate goal. It discusses the design of the workflow, the validation and verification of its components on the example of impurity solver and demonstrates a proof-of-principles coupling of a local gyrofluid model for turbulent transport to the ETS. It also presents the first results on the application of the ETS to JET tokamak discharges with the ITER like wall. It studies the correlations of the radiation from impurity to the choice of the sources and transport coefficients.

  8. Gas-Phase Photoionization Of A Protein

    NASA Astrophysics Data System (ADS)

    Milosavljevic, A. R.; Giuliani, A.; Nicolas, C.; Gil, J.-F.; Lemaire, J.; Refregiers, M.; Nahon, L.

    2010-07-01

    We present preliminary results on gas phase photoionization of electrosprayproduced multiply protonated cytochrome c protein (104 amino acids; ˜12.4 kDa), which has been achieved with a newly developed experimental system for spectroscopy of electrosprayed ions in a linear quadrupole ion trap using a monochromatized vacuum ultraviolet (VUV) synchrotron radiation and tandem mass spectrometry method. The investigation of proteins in the gas phase, where they are free of the influence of counterions and solvent molecules, offer a possibility to understand their intrinsic molecular properties. However, due to limited both ion densities and available number of photons, the use of synchrotron radiation for the trapped ions spectroscopy is a rather challenging task. The feasibility of coupling a Fourier transform ion cyclotron resonance ion trap with soft x-ray synchrotron beamline and the first successful use of synchrotron radiation for spectroscopy of electrosprayed negative ions stored in a three-dimensional quadrupole ion trap have been demonstrated only recently (R. Thissen et al., 2008, Phys. Rev. Lett., 100, 223001; A. Giulliani et al., Proc. 57th ASMS Conf., Philadelphia, 2009). The present results are the first reported on photoionization of kDa species in the gas phase and are valuable regarding both a fundamental interest of accessing physical properties of large biological ions isolated in vacuo and potential development of a new technique for proteomics.

  9. Impurity Transport and Sawteeth Investigation by X-Ray Filter Method in the Madison Symmetric Torus Reversed Field Pinch

    NASA Astrophysics Data System (ADS)

    Bogatu, Ioan-Niculae; Pantea, Alexandra; Hokin, Samuel A.

    1996-11-01

    A simple multi-foil Ross-like filter X-ray spectrometer footnote S.A.Hokin, et al., 9th Topical Conf.on High Temperature Plasma Diagnostics, Santa Fe, New Mexico (1992)., able to discriminate between the charge states of the impurity ions, was used for the measurement of the He-like and H-like carbon and oxygen lines evolution. The chord integrated signals, normalized respectively to their maximum values, are compared as to their shape, peak time, and decay with the results of the MIST impurity transport code footnote R.A.Hulse, Nucl. Technology/Fusion 3 (1983) 259.. The plasma current and the line averaged electron density are used as input data for the code together with a plasma parameter profile model. The comparison made simultaneously for different ions provides a better confidence in the determined value of particle diffusion coefficient and for the sawteeth electron temperature dynamics investigation in the MST RFP plasma (I.N.Bogatu, et al., in Proc. Int. School of Plasma Physics "Plasma Physics and Technology", La Jolla, August 8-18, 1995.).

  10. Physics of radiation-driven islands near the tokamak density limit

    NASA Astrophysics Data System (ADS)

    Gates, D. A.; Delgado-Aparicio, L.; White, R. B.

    2013-06-01

    In previous work (Gates and Delgado-Aparicio 2012 Phys. Rev. Lett. 108 165004), the onset criterion for radiation-driven islands (Rebut et al 1985 Proc. 10th Int. Conf. on Plasma Physics and Controlled Nuclear Fusion Research 1984 (London, UK, 1984) vol 2 (Vienna: IAEA) p 197) in combination with a simple cylindrical model of tokamak current channel behaviour was shown to be consistent with the empirical scaling of the tokamak density limit (Greenwald et al 1988 Nucl. Fusion 28 2199). A number of the unexplained phenomena at the density limit are consistent with this novel physics mechanism. In this work, a more formal theoretical underpinning, consistent with cylindrical tearing mode theory, is developed for the onset criteria of these modes. The appropriate derivation of the radiation-driven addition to the modified Rutherford equation (MRE) is discussed. Additionally, the ordering of the terms in the MRE is examined in a regime near the density limit. It is hoped that, given the apparent success of this simple model in explaining the observed global scalings, it will lead to a more comprehensive analysis of the possibility that radiation-driven islands are the physics mechanism responsible for the density limit. In particular, with modern diagnostic capabilities detailed measurements of current densities, electron densities and impurity concentrations at rational surfaces should be possible, enabling verification of the concepts described above.

  11. Light scattering of human skin: a comparison between zinc (II)-phthalocyanine and photofrin II.

    PubMed

    Ochsner, M

    1996-01-01

    Zinc(II)-phthalocyanine is the active component of the liposomal formulation CGP 55847 which showed a highly activity in photodynamic therapy studies on a variety of animal tumours (K. Schieweck et al., SPIE Conf. Proc., 2078 (1994) 107-118). The photophysical properties of zinc(II)-phthalocyanine have been studied in detail and compared with those of Photofrin II(R), the only sensitizing agent approved so far for Phase III and IV clinical trials (M. Ochsner-Bruderer, Inaugural Dissertation, University of Basle, 1994). As will be shown in a series of papers, the main photophysical properties of zinc(II)-phthalocyanine are significantly better than those of Photofrin II(R) (M. Ochsner-Bruderer, Inaugural Dissertation, University of Basle, 1994). In this paper we especially consider the effect of the absorption wavelength on the penetration of light into the human skin. The results clearly show that the longer absorption wavelength of zinc(II)-phthalocyanine causes a deeper penetration of light into the human skin as compared with Photofrin II(R). In addition to this, the higher extinction coefficient (epsilon S) lowers the zinc(II)-phthalocyanine dose required to induce a tumour necrosis.

  12. Unifying Paschen Curve Conditions across Pressure and Gap Distance

    NASA Astrophysics Data System (ADS)

    Loveless, Amanda; Garner, Allen; Valfells, Agust

    2015-11-01

    The Paschen curve (PC) predicts the breakdown voltage of a gas by relating it to the product of pressure and gap distance (pd). Recent experiments deviate from the PC for microscale gaps at low pd. A scaling law incorporating field emission-driven breakdown and field enhancement to the macroscale Paschen law yields more accurate predictions for microscale gaps (A. Venkattraman and A. A. Alexeenko, Phys. Plasmas 19, 123515 (2012).). While many studies consider low pd, deviations from the PC also arise at high pd, as demonstrated for gap distances between 0.0508 and 0.254 cm and pressures between 96.5 and 6900 kPa (W. J. Carey, A. J. Wiebe, R. D. Nord, and L. L. Altgilbers, in Proc. IEEE Pulsed Power Conf., 2011, pp. 741-744). High pd values are relevant for ongoing high voltage plasma experiments for food treatment and combustion. We attempt to elucidate the impact of large gap distances (~ 5 cm) and higher pressures (~ 200-300 kPa) on these deviations by connecting recent work at low pd to high pd by assessing scaling laws, analyzing field emission models, and using particle-in-cell codes. Implications on experimental design will be discussed, and the development of a universal Paschen curve will be explored.

  13. Compatibility of the Radiating Divertor with High Performance Plasmas in DIII-D

    SciTech Connect

    Petrie, T W; Wade, M R; Brooks, N H; Fenstermacher, M E; Groth, M; Hyatt, A W; Isler, R C; Lasnier, C J; Leonard, A W; Mahdavi, M A; Porter, G D; Schaffer, M J; Watkins, J G; West, W P

    2006-05-18

    A radiating divertor approach was successfully applied to high performance 'hybrid' plasmas [M.R. Wade, et al., Proc. 20th IAEA Fusion Energy Conf., Vilamoura, (2004)]. Our technique included: (1) injecting argon near the outer divertor target, (2) enhancing the plasma flow into the inner and outer divertors by a combination of particle pumping and deuterium gas puffing upstream of the divertor targets, and (3) isolating the inner divertor from the outer by a structure in the private flux region. Good hybrid conditions were maintained, as the peak heat flux at the outer divertor target was reduced by a factor of 2.5; the peak heat flux at the inner target decreased by 20%. This difference was caused by a higher concentration of argon at the outer target than at the inner target. Argon accumulation in the main plasma was modest (n{sub AR}/n{sub e} {le}0.004 on axis), although the argon profile was more peaked than the electron profile.

  14. Interpreting the Elliptical Crater Populations on Mars, Venus, and the Moon

    NASA Astrophysics Data System (ADS)

    Bottke, William F.; Love, Stanley G.; Tytell, David; Glotch, Timothy

    2000-05-01

    Asteroids or comets striking a planetary surface at very shallow angles produce elliptical-shaped craters. According to laboratory impact experiments (D. E. Gault and J. A. Wedekind 1978, Proc. Lunar Planet. Sci. Conf. 9th, 3843-3875), elliptical craters result from impact angles within ˜5° of horizontal and less than 1% of projectiles with isotropic impact trajectories create elliptical craters. This result disagrees with survey results which suggest that approximately 5% of all kilometer-sized craters formed on Mars, Venus, and the Moon have elliptical shapes. To explain this discrepancy, we examined the threshold incidence angle necessary to produce elliptical craters in laboratory impact experiments. Recent experiments show that aluminum targets produce elongated craters at much steeper impact angles than sand targets. This suggests that target properties are as important as the projectile's impact angle in determining the eventual ellipticity of the crater. Creating a model which interpolates between impact data produced using sand and aluminum targets, we derive a new elliptical crater threshold angle of 12° from horizontal for Mars, Venus, and the Moon. This leads to a predicted proportion of elliptical craters that matches observations within uncertainty given a random projectile population. We conclude that the observed proportion of elliptical craters on these bodies is a natural by-product of projectiles striking at random angles, and that no additional formation mechanisms are needed.

  15. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.

    PubMed

    Tal-Gan, Yftah; Stacy, Danielle M; Blackwell, Helen E

    2014-03-21

    We report the first N-methyl and peptoid residue scans of a full-length autoinducing peptide (AIP), AIP-III, used by Staphylococcus aureus for quorum sensing (QS). Biological evaluation of these AIP-III analogues uncovered new features of the AIP-III scaffold that can be tuned to develop chemical probes of QS in all four groups of S. aureus (I-IV).

  16. Creating and Sustaining University-Community Partnerships in Science Education (Invited)

    NASA Astrophysics Data System (ADS)

    Finkelstein, N.

    2009-12-01

    Despite years of research and investment, we have yet to see the widespread implementation of a myriad research-proven instructional strategies in STEM education[1]. To address this challenge, we present and analyze one such strategy, a theoretically-grounded model of university-community partnership [2] that engages university students and children in a collective enterprise that has the potential to improve the participation and education of all. We document the impact of this effort on: university participants who learn about education, the community and science; children in the community who learn about science, the nature of science and develop their identities and attitudes towards science; and, shifts in institutional structures which may allow these programs to be part of standard practice. This project is designed to be sustained and scaled, and is analyzed through the application of a new framework [3] which brings together theories of STEM change that come from studies in higher education, faculty development and disciplinary-based education research in STEM. [1] National Research Council. (2003). Improving Undergraduate Instruction in Science, Technology, Engineering, and Mathematics: Report of A Workshop. Washington, D.C.: The National Academies Press. [2] Finkelstein, N. and Mayhew, L. (2008). Acting in Our Own Self-Interest: Blending University and Community. Proceedings of the 2008 Physics Education Research Conf, AIP Press. Melville NY, 1064, 19-22. [3] Henderson, C., Finkelstein, N. & Beach A. (to appear). Beyond Dissemination in College science teaching: An Introduction to Four Core Change Strategies. Accepted May 2009 in Journal of College Science Teaching.

  17. Chemical evolution of dust: the delayed injection of PAHs into the ISM

    NASA Astrophysics Data System (ADS)

    Galliano, F.; Dwek, E.; Chanial, P.

    2005-12-01

    Recent Spitzer and ISO observations (Engelbracht et al. 2005, ApJ, 628, L29; Madden et al. 2005, A&A, astro-ph/0510086) have confirmed the correlation between the metallicity, Z, of a galaxy's ISM and the relative intensity of the thermal emission by its Polycyclic Aromatic Hydrocarbons (PAHs). One explanation that has been proposed to this phenomenon is that the low dust content of low-metallicity environments allows the hard radiation field to penetrate deeply in the ISM and photoevaporate the PAHs. However, this explanation supposes the existence of PAHs in low-metallicity environments. Since PAHs are produced in AGB stars, an alternative explanation is that their paucity in low-metallicity environments is the result of their delayed injection ( ˜ 300 Myr, a typical main sequence lifetime) into the ISM, compared to the prompt ( ˜ 10 Myr) metal enrichment by supernovae (Dwek 2005, AIP Conf. Series No. 761, page 103). To test this hypothesis, we calculated the abundance of PAHs in a sample of 37 nearby galaxies of various morphologies, with Z values ranging from 1/50 to 3\\:Z⊙, observed by ISO/CAM or Spitzer/IRS. Our results show that the PAH/HI abundance ratio is clearly correlated with metallicity, in good agreement with the prediction of our dust evolution model (Dwek 1998, ApJ, 501, 643). These results are the first observational evidence of the delayed injection of carbon dust by AGB stars, providing an estimate of their formation efficiency in these stars. Furthermore, this work can be used to convert the PAH contribution to galaxies' SEDs into PAH/HI abundances as a function of ISM metallicity.

  18. 50 CFR 253.12 - Credit application.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or an applicant withdraws its application before the Program issues an AIP letter, as described in § 253.13(e). The Program will not issue an AIP letter if any of the application fee remains unpaid. No portion of the application fee shall be refunded once the Program issues an AIP letter. (c)...

  19. 75 FR 78798 - Airport Improvement Program: Proposed Changes to Benefit Cost Analysis (BCA) Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... (AIP) grants for capacity projects at the discretion of the Secretary of Transportation. This modification proposes to raise the threshold at which BCAs are required, from $5 million to $10 million in AIP...://www.faa.gov/airports/aip/bc_analysis/ . In addition, hard copies can be reviewed at Room 619,...

  20. 50 CFR 253.12 - Credit application.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or an applicant withdraws its application before the Program issues an AIP letter, as described in § 253.13(e). The Program will not issue an AIP letter if any of the application fee remains unpaid. No portion of the application fee shall be refunded once the Program issues an AIP letter. (c)...

  1. 50 CFR 253.12 - Credit application.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... or an applicant withdraws its application before the Program issues an AIP letter, as described in § 253.13(e). The Program will not issue an AIP letter if any of the application fee remains unpaid. No portion of the application fee shall be refunded once the Program issues an AIP letter. (c)...

  2. Advice from Rural Elders: What It Takes to Age in Place

    ERIC Educational Resources Information Center

    Dye, Cheryl J.; Willoughby, Deborah F.; Battisto, Dina G.

    2011-01-01

    Older adults prefer to age in place (AIP), and there are psychological, physiological, and economic benefits in doing so. However, it is especially challenging to AIP in rural communities. AIP models have been tested in urban settings and age-segregated communities, but they are not appropriate for rural communities. This paper presents rural AIP…

  3. Arts Integration: Semiotic Transmediation in the Classroom.

    ERIC Educational Resources Information Center

    Betts, J. David; And Others

    This study describes two years of research with the Arts Integration Program (AIP) of the Tucson Pima Arts Council, Tucson, AZ. AIP supports teachers in integrating fine arts activities into their classrooms. AIP provides lesson outlines and demonstration lessons by arts specialists in music, dance, theater arts, and visual arts. The initial phase…

  4. Design and Hardware Implementation of Neural Systems.

    DTIC Science & Technology

    1991-12-15

    orientation specificity in a neuron network for visual image decomposition. AIP Conference on Neuronal Networks for Computing, Snowbird, Utah, April, 1989...P. and Blackman, D. Orientation tuning and orientation specificity in a neuron network for visual image decomposition. AIP Conference on Neuronal ... Networks for Computing, Snowbird, Utah, April, 1989. Mueller, P., Neural computation of pattern primitives, (Abstract) AIP Conference, Snowbird, Utah

  5. Recent Advances in Autoimmune Pancreatitis.

    PubMed

    Hart, Phil A; Zen, Yoh; Chari, Suresh T

    2015-07-01

    Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that is characterized clinically by frequent presentation with obstructive jaundice, histologically by a dense lymphoplasmacytic infiltrate with fibrosis, and therapeutically by a dramatic response to corticosteroid therapy. Two distinct diseases, type 1 and type 2 AIP, share these features. However, these 2 diseases have unique pancreatic histopathologic patterns and differ significantly in their demographic profiles, clinical presentation, and natural history. Recognizing the popular and long-standing association of the term "AIP" with what is now called "type 1 AIP," we suggest using "AIP" solely for type 1 AIP and to acknowledge its own distinct disease status by using "idiopathic duct-centric chronic pancreatitis" (IDCP) for type 2 AIP. AIP is the pancreatic manifestation of immunoglobulin G4-related disease (IgG4-RD). The etiopathogenesis of AIP and IgG4-RD is largely unknown. However, the remarkable effectiveness of B-cell depletion therapy with rituximab in patients with AIP and IgG4-RD highlights the crucial role of B cells in its pathogenesis. IDCP is less commonly recognized, and little is known about its pathogenesis. IDCP has no biomarker but is associated with inflammatory bowel disease in ~25% of patients. Recently, the international consensus diagnostic criteria for AIP identified combinations of features that are diagnostic of both diseases. Both AIP and IDCP are corticosteroid responsive; however, relapses are common in AIP and rare in IDCP. Therefore, maintenance therapy with either an immunomodulator (eg, azathioprine, 6-mercaptopurine, or mycophenolate mofetil) or rituximab is often necessary for patients with AIP. Long-term survival is excellent for both patients with AIP and patients with IDCP.

  6. Dielectronic Satellite Lines of Fe XVII

    NASA Astrophysics Data System (ADS)

    Beiersdorfer, Peter; Brown, Gregory V.; Laska, Alexander; Lepson, Jaan K.

    2015-08-01

    . C. Johns-Krull, M. K. Browning, and A. A. West (San Francisco:Astronomical Society of the Pacific), 787 (2011)[3] P. Beiersdorfer et al., ApJ., 793, 99 (2014)[4] P. Beiersdorfer et al., J. Phys. Conf. Proc. 583, 012022 (2015)

  7. Acute intermittent porphyria: identification and expression of exonic mutations in the hydroxymethylbilane synthase gene. An initiation codon missense mutation in the housekeeping transcript causes "variant acute intermittent porphyria" with normal expression of the erythroid-specific enzyme.

    PubMed Central

    Chen, C H; Astrin, K H; Lee, G; Anderson, K E; Desnick, R J

    1994-01-01

    Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme, hydroxymethylbilane synthase (EC 4.3.1.8). Diagnosis of AIP heterozygotes is essential to prevent acute, life-threatening neurologic attacks by avoiding various precipitating factors. Since biochemical diagnosis is problematic, the identification of hydroxymethylbilane synthase mutations has facilitated the detection of AIP heterozygotes. Molecular analyses of unrelated AIP patients revealed six exonic mutations: an initiating methionine to isoleucine substitution (M1I) in a patient with variant AIP, which precluded translation of the housekeeping, but not the erythroid-specific isozyme; four missense mutations in classical AIP patients, V93F, R116W, R201W, C247F; and a nonsense mutation W283X in a classical AIP patient, which truncated the housekeeping and erythroid-specific isozymes. Each mutation was confirmed in genomic DNA from family members. The W283X lesion was found in another unrelated AIP family. Expression of each mutation in Escherichia coli revealed that R201W, C247F, and W283X had residual activity. In vitro transcription/translation studies indicated that the M1I allele produced only the erythroid-specific enzyme, while the other mutant alleles encoded both isozymes. These mutations provide insight into the molecular pathology of classic and variant AIP and facilitate molecular diagnosis in AIP families. Images PMID:7962538

  8. [Pathophysiology and Assessment of IgG4-Related Disease--Focus on Autoimmune Pancreatitis].

    PubMed

    Uehara, Takeshi

    2015-10-01

    IgG4-related disease is well-known, and while the functions of cytokines which affect IgG4 production are being clarified, it remains unclear what causes it. There are many clinicopathological characteristics of IgG4-related disease and, therefore, comprehensive criteria are used for diagnosis. Notably, histopathological findings are the most important of these, with which we cannot make a definite diagnosis. The model disease of an IgG4-related disease is autoimmune pancreatitis (AIP). Currently, AIP is classified into type 1 (AIP1) and type 2 (AIP2). AIP1 is IgG4-related while AIP2 is not. AIP1 sometimes has localized mass formation, making it difficult to distinguish between AIP1 and pancreatic cancer. Thus, upon biochemical and immunological examination, the IgG4 level is the most useful for the diagnosis, although the levels of IL-2R, β2MG, C4, and monoclonal rheumatoid factor are also useful for the assessment of disease. In addition, histopathological findings are also important to diagnose AIP1. Typical AIP1 cases show lymphoplasmacytic infiltration including IgG4-positive plasma cells with storiform fibrosis. A careful analysis of cases with the typical features of IgG4-related disease will lead to the elucidation of the mechanism behind IgG4-related disease.

  9. Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass

    PubMed Central

    Macinga, Peter; Pulkertova, Adela; Bajer, Lukas; Maluskova, Jana; Oliverius, Martin; Smejkal, Martin; Heczkova, Maria; Spicak, Julius; Hucl, Tomas

    2017-01-01

    AIM To assess the occurrence of autoimmune pancreatitis (AIP) in pancreatic resections performed for focal pancreatic enlargement. METHODS We performed a retrospective analysis of medical records of all patients who underwent pancreatic resection for a focal pancreatic enlargement at our tertiary center from January 2000 to July 2013. The indication for surgery was suspicion of a tumor based on clinical presentation, imaging findings and laboratory evaluations. The diagnosis of AIP was based on histology findings. An experienced pathologist specialized in pancreatic disease reviewed all the cases and confirmed the diagnosis in pancreatic resection specimens suggestive of AIP. The histological diagnosis of AIP was set according to the international consensus diagnostic criteria. RESULTS Two hundred ninety-five pancreatic resections were performed in 201 men and 94 women. AIP was diagnosed in 15 patients (5.1%, 12 men and 3 women) based on histology of the resected specimen. Six of them had AIP type 1, nine were diagnosed with AIP type 2. Pancreatic adenocarcinoma (PC) was also present in six patients with AIP (40%), all six were men. Patients with AIP + PC were significantly older (60.5 vs 49 years of age, P = 0.045), more likely to have been recently diagnosed with diabetes (67% vs 11%, P = 0.09), and had experienced greater weight loss (15.5 kg vs 8.5 kg, P = 0.03) than AIP patients without PC. AIP was not diagnosed in any patients prior to surgery; however, the diagnostic algorithm was not fully completed in every case. CONCLUSION The possible co-occurrence of PC and AIP suggests that preoperative diagnosis of AIP does not rule out simultaneous presence of PC.

  10. Thermal decomposition of gaseous ammonium nitrate at low pressure: kinetic modeling of product formation and heterogeneous decomposition of nitric acid.

    PubMed

    Park, J; Lin, M C

    2009-12-03

    The thermal decomposition of ammonium nitrate, NH(4)NO(3) (AN), in the gas phase has been studied at 423-56 K by pyrolysis/mass spectrometry under low-pressure conditions using a Saalfeld reactor coated with boric acid. The sublimation of NH(4)NO(3) at 423 K was proposed to produce equal amounts of NH(3) and HNO(3), followed by the decomposition reaction of HNO(3), HNO(3) + M --> OH + NO(2) + M (where M = third-body and reactor surface). The absolute yields of N(2), N(2)O, H(2)O, and NH(3), which can be unambiguously measured and quantitatively calibrated under a constant pressure at 5-6.2 torr He are kinetically modeled using the detailed [H,N,O]-mechanism established earlier for the simulation of NH(3)-NO(2) (Park, J.; Lin, M. C. Technologies and Combustion for a Clean Environment. Proc. 4th Int. Conf. 1997, 34-1, 1-5) and ADN decomposition reactions (Park, J.; Chakraborty, D.; Lin, M. C. Proc. Combust. Inst. 1998, 27, 2351-2357). Since the homogeneous decomposition reaction of HNO(3) itself was found to be too slow to account for the consumption of reactants and the formation of products, we also introduced the heterogeneous decomposition of HNO(3) in our kinetic modeling. The heterogeneous decomposition rate of HNO(3), HNO(3) + (B(2)O(3)/SiO(2)) --> OH + NO(2) + (B(2)O(3)/SiO(2)), was determined by varying its rate to match the modeled result to the measured concentrations of NH(3) and H(2)O; the rate could be represented by k(2b) = 7.91 x 10(7) exp(-12 600/T) s(-1), which appears to be consistent with those reported by Johnston and co-workers (Johnston, H. S.; Foering, L.; Tao, Y.-S.; Messerly, G. H. J. Am. Chem. Soc. 1951, 73, 2319-2321) for HNO(3) decomposition on glass reactors at higher temperatures. Notably, the concentration profiles of all species measured could be satisfactorily predicted by the existing [H,N,O]-mechanism with the heterogeneous initiation process.

  11. Thermal Decomposition of Gaseous Ammonium Nitrate at Low Pressure: Kinetic Modeling of Product Formation and Heterogeneous Decomposition of Nitric Acid

    NASA Astrophysics Data System (ADS)

    Park, J.; Lin, M. C.

    2009-10-01

    The thermal decomposition of ammonium nitrate, NH4NO3 (AN), in the gas phase has been studied at 423-56 K by pyrolysis/mass spectrometry under low-pressure conditions using a Saalfeld reactor coated with boric acid. The sublimation of NH4NO3 at 423 K was proposed to produce equal amounts of NH3 and HNO3, followed by the decomposition reaction of HNO3, HNO3 + M → OH + NO2 + M (where M = third-body and reactor surface). The absolute yields of N2, N2O, H2O, and NH3, which can be unambiguously measured and quantitatively calibrated under a constant pressure at 5-6.2 torr He are kinetically modeled using the detailed [H,N,O]-mechanism established earlier for the simulation of NH3-NO2 (Park, J.; Lin, M. C. Technologies and Combustion for a Clean Environment. Proc. 4th Int. Conf. 1997, 34-1, 1-5) and ADN decomposition reactions (Park, J.; Chakraborty, D.; Lin, M. C. Proc. Combust. Inst. 1998, 27, 2351-2357). Since the homogeneous decomposition reaction of HNO3 itself was found to be too slow to account for the consumption of reactants and the formation of products, we also introduced the heterogeneous decomposition of HNO3 in our kinetic modeling. The heterogeneous decomposition rate of HNO3, HNO3 + (B2O3/SiO2) → OH + NO2 + (B2O3/SiO2), was determined by varying its rate to match the modeled result to the measured concentrations of NH3 and H2O; the rate could be represented by k2b = 7.91 × 107 exp(-12 600/T) s-1, which appears to be consistent with those reported by Johnston and co-workers (Johnston, H. S.; Foering, L.; Tao, Y.-S.; Messerly, G. H. J. Am. Chem. Soc. 1951, 73, 2319-2321) for HNO3 decomposition on glass reactors at higher temperatures. Notably, the concentration profiles of all species measured could be satisfactorily predicted by the existing [H,N,O]-mechanism with the heterogeneous initiation process.

  12. Progress of astrometric research in Nikolaev Observatory

    NASA Astrophysics Data System (ADS)

    Ivantsov, Anatoliy; Maigurova, Nadia; Martynov, Maxim; Pinigin, Gennadiy

    2012-08-01

    A catalog of astrometric positions and proper motions of 140237 stars in fields of ecliptical zone and high proper motion stars was derived from CCD - observations made at AMC telescope (Nikolaev) in 2008 - 2009. The UCAC2 catalog was used as a reference one for astrometric reductions. The standard error for a single position is 20 - 65 mas in right ascension and 30 - 70 mas in declination. Cross - identification of the obtained data with modern astrometric catalogs such as TYCHO2, 2MASS, CMC14, PPMX, XPM, USNO - A2.0 and XPM - 1.0 was made for investigation systematical errors and calculation of the proper motions [1]. The final catalog contains star positions, proper motions as well as photometric data (B, V, r ´, J, H, K) taken from other catalogs. For analysis of perturbed motion of selected asteroids, there was made astrometric reduction for three thousands of positions of 68 selected asteroids observed at the Russian - Turkish telescope RTT150 in 2008 - 2011 [2]. The research is conducted within the International Joint Project between IMCCE (France), NAO (Ukraine), KFU (Russia), and TUG (Turkey). The reduction was made with the UCAC2 and UCAC3 catalogs. The standard error of a single position is 0.15 arcsec in right ascension and 0.13 arcsec in declination. Also, the first results of astrometric reduction are presented for the observations of selected asteroids made at the AZT8 (Evpatoriya ) and Mobitel (Nikolaev) telescopes. The obtained positions are expected to be used for derivation masses of asteroids by dynamical method. This work is supported by State Agency on Science, Innovation and Information of Ukraine, Russian Foundation for Basic Research. 1. Jin, W., Pinigin, G., Tang, Zh., Shulga, A. (2011). The collaboration between ShAO and NAO: Celebration of the 1 90th anniversary of NAO. Proc. Int. Conf. “Astronomical Research: from near - Earth Space to the Galaxy”, Nikolaev (pp. 92 - 104). 2 . Ivantsov, A., Gumerov, R., Khamitov, I., Aslan, Z

  13. How Old is Cone Crater at the Apollo 14 Landing Site?

    NASA Astrophysics Data System (ADS)

    Hiesinger, Harald; Simon, Ina; van der Bogert, Carolyn H.; Robinson, Mark S.; Plescia, Jeff B.

    2015-04-01

    and 23 Ma older than the exposure ages [e.g., 10]. We find that CSFD measurements performed on the ejecta blanket of Cone crater yield AMAs that agree well with the exposure ages, considering the relatively small count areas and the hummocky nature of the ejecta blanket. However, the AMAs are generally older than the exposure ages, which may be due to the small count area sizes [16], a possibly higher recent impact rate [17], some unidentified secondary craters [13], poor calibration of the production function, or inaccurate exposure ages. [1] Hiesinger et al. (2012) J. Geophys. Res. 117. [2] Stöffler and Ryder (2001) Chronology and Evolution of Mars. [3] Neukum (1983) Habil. thesis, U. of Munich. [4] Neukum et al. (2001) Space Sci. Rev. 96. [5] Swann et al. (1971) Apollo 14 Prelim. Sci. Rep. [6] Carlson (1978) NASA STI/Recon Technical Report. [7] Swann (1977) Washington US Govt. Print. Off. [8] Bhandari et al. (1972) Proc. Lunar Planet. Sci. Conf. 3. [9] Crozaz et al. (1972) Proc. Lunar Planet. Sci. Conf. 3. [10] Arvidson et al. (1975) Moon 13. [11] Stadermann et al. (1991) Geochim. Cosmochim. Acta 55. [12] Moore et al. (1980) Moon and Planets 23. [13] Plescia and Robinson (2011) LPSC 42. [14] Williams et al. (2014) Icarus 235. [15] Robbins (2014) Earth Planet. Sci. Lett. 403. [16] van der Bogert et al. (2015) LPSC 46. [17] McEwen et al. (2015) LPSC 46.

  14. Areal Crater Density Analysis of Volcanic Smooth Plains: A New Approach to Distinguishing Age Units

    NASA Astrophysics Data System (ADS)

    Ostrach, L. R.; Robinson, M. S.

    2013-12-01

    and composition) are not observed on Mercury [e.g., 13-15], so the ACD method can be used to test hypotheses concerning timing of smooth plains emplacement [15]. [1] Hartmann W.K. et al. (1981) In: BVTP, 1049-1127. [2] Stöffler D. et al. (2006) Rev. Mineral. Geochem, 60, 519-596. [3] Hiesinger H. et al. (2011) Spec. Pap. - Geol. Soc. Am, 477, 1-51. [4] Pieters C.M. (1978) Proc. Lunar Plan. Sci. Conf, 9th, 2825-2849. [5] Hiesinger H. et al. (2000) J. Geophys. Res, 105, 29239-29275. [6] Staid M.I. and C.M. Pieters (2001) J. Geophys. Res, 106, 27887-27900. [7] Staid M.I. et al. (2011) J. Geophys. Res, 116, E00G10. [8] Lucey P.G. et al. (2000) J. Geophys. Res, 105, 20297-20306. [9] Schaber G.G. (1973) In: Apollo 17 PSR, NASA SP-330, 30-17 to 30-25. [10] Schaber G.G. et al. (1975) The Moon, 13, 395-423. [11] Boyce J.M. and A.L. Dial Jr. (1975) Proc. Lunar Sci. Conf, 6th, 2585-2595. [12] Bugiolacchi R. and J.E. Guest (2008) Icarus, 197, 1-18. [13] Robinson M.S. et al. (2008) Science, 321, 66-69. [14] Denevi B.W. et al. (2009) Science, 324, 613-618. [15] Denevi B.W. et al. (2013) J. Geophys. Res, 118, 1-17.

  15. Near-surface magnetic fields and dust transport at lunar swirls (Invited)

    NASA Astrophysics Data System (ADS)

    Garrick-Bethell, I.; Head, J. W.; Pieters, C. M.

    2009-12-01

    in both band strength and albedo as the distance from the swirl increases. This pattern is not expected for changes in weathering state, but is similar to what is observed across mare units of different composition, suggesting swirls are not due to solar wind weathering differences, at least as we presently understand the process. An alternative hypothesis to the standoff model is motivated by the observation that lunar crustal magnetic anomalies produce weak electric fields when they interact with the solar wind [2]. The electric field is produced by charge separation due to the differential penetration of electrons and protons into the magnetic field. Such electric fields may be responsible for moving fine, electrostatically lofted dust [3] within swirl regions, thereby changing the spectral properties of the swirl. We modeled this process based on the electric field strengths inferred from charged particle measurements at the Apollo 12 and 14 magnetic anomalies, and found that small but significant amounts of fine dust may have moved out of swirl regions continuously for billions of years. This hypothesis can be further tested by better spectral and topographic data. [1] Hood, L.L. & Williams, C.R. (1989) Proc. Lunar Sci. Conf. 19th, 99. [2] Neugebauer, M. et al. (1972) Planet. Space. Sci. 20, 1577. [3] Criswell, D.R. (1972) Proc. Lunar Sci. Conf. 3rd, 2671.

  16. The Dramatic Effect of Chlorine on Magmatic Phase Relations

    NASA Astrophysics Data System (ADS)

    Webster, J. D.; McBirney, A. R.

    2001-12-01

    apparent speciation reactions for Cl in these melts. These experiments demonstrate that the solubility of Cl is most strongly controlled by Ca and Mg in "dry" melts, followed by Fe, F, Na, K, and Al (in that order). These experiments suggest that Cl associates with Ca and Mg in aluminosilicate melts, which should promote the evolution of Cl-enriched magmas toward compositions enriched in (Ca + Mg) relative to (Al + Na + K). Enhanced levels of Cl should also tend to destabilize Ca- and Mg-enriched minerals relative to Ca- and Mg-enriched melts, and Cl should tend to lower the liquidus temperatures of mafic minerals relative to plagioclase (opposite to the effect of PH2O on phase relations). Lassiter, J.C. and Hauri, E.H. (2001) Proc. of 11th Ann. Gold. Conf., #3639pdf. Webster, J.D. and Mathez, E.A. (2001) Proc. of 11th Ann. Gold. Conf., #3164pdf.

  17. Failure Wave in DEDF and Soda-Lime Glass During Rod Impact

    NASA Astrophysics Data System (ADS)

    Orphal, Dennis; Behner, Thilo; Anderson, Charles; Templeton, Douglas

    2005-07-01

    Investigations of glass by planar, and classical and symmetric Taylor impact experiments reveal that failure wave velocity U/F depends on impact velocity, geometry, and the type of glass. U/F typically increases with impact velocity to between ˜ 1.4 C/S and C/L (shear and longitudinal wave velocities, respectively). This paper reports the results of direct high-speed photographic measurements of the failure wave for gold rod impact from 1.2 and 2.0 km/s on DEDF glass (C/S = 2.0, C/L =3.5 km/s). The average rod penetration velocity, u, was measured using flash X-rays. Gold rods eliminated penetrator strength effects. U/F for gold rod impact on DEDF is ˜ 1.0-1.2 km/s, which is considerably less than C/S. The increase of u with impact velocity is greater than that of U/F. These results are confirmed by soda-lime glass impact on a gold rod at an impact velocity of 1300 m/s. Similar results are found in``edge-on-impact'' tests; U/F values of 1.4 km/s and 2.4-2.6 km/s in soda-lime glass are reported for W-alloy rod impact, considerably less than C/S (3.2 km/s) [1,2]. [1] Bless, et. al.(1990) AIP Proc. Shock Comp. Cond. Matter---1989, pp. 939-942 (1990) [2] E. L. Zilberbrand, et. al. (1999) Int. J. Impact Engng., 23, 995-1001 (1999).

  18. Re-analysis of previous laboratory phase curves: 1. Variations of the opposition effect morphology with the textural properties, and an application to planetary surfaces

    NASA Astrophysics Data System (ADS)

    Déau, Estelle; Flandes, Alberto; Spilker, Linda J.; Petazzoni, Jérôme

    2013-11-01

    Typical variations in the opposition effect morphology of laboratory samples at optical wavelengths are investigated to probe the role of the textural properties of the surface (roughness, porosity and grain size). A previously published dataset of 34 laboratory phase curves is re-analyzed and fit with several morphological models. The retrieved morphological parameters that characterize the opposition surge, amplitude, width and slope (A, HWHM and S respectively) are correlated to the single scattering albedo, the roughness, the porosity and the grain size of the samples. To test the universality of the laboratory samples’ trends, we use previously published phase curves of planetary surfaces, including the Moon, satellites and rings of the giant planets. The morphological parameters of the surge (A and HWHM) for planetary surfaces are found to have a non-monotonic variation with the single scattering albedo, similar to that observed in asteroids (Belskaya, I.N., Shevchenko, V.G. [2000]. Icarus 147, 94-105), which is unexplained so far. The morphological parameters of the surge (A and HWHM) for laboratory samples seem to exhibit the same non-monotonic variation with single scattering albedo. While the non-monotonic variation with albedo was already observed by Nelson et al. (Nelson, R.M., Hapke, B.W., Smythe, W.D., Hale, A.S., Piatek, J.L. [2004]. Planetary regolith microstructure: An unexpected opposition effect result. In: Mackwell, S., Stansbery, E. (Eds.), Proc. Lunar Sci. Conf. 35, p. 1089), we report here the same variation for the angular width.

  19. Fish and chips: implementation of a neural network model into computer chips to maximize swimming efficiency in autonomous underwater vehicles.

    PubMed

    Blake, R W; Ng, H; Chan, K H S; Li, J

    2008-09-01

    Recent developments in the design and propulsion of biomimetic autonomous underwater vehicles (AUVs) have focused on boxfish as models (e.g. Deng and Avadhanula 2005 Biomimetic micro underwater vehicle with oscillating fin propulsion: system design and force measurement Proc. 2005 IEEE Int. Conf. Robot. Auto. (Barcelona, Spain) pp 3312-7). Whilst such vehicles have many potential advantages in operating in complex environments (e.g. high manoeuvrability and stability), limited battery life and payload capacity are likely functional disadvantages. Boxfish employ undulatory median and paired fins during routine swimming which are characterized by high hydromechanical Froude efficiencies (approximately 0.9) at low forward speeds. Current boxfish-inspired vehicles are propelled by a low aspect ratio, 'plate-like' caudal fin (ostraciiform tail) which can be shown to operate at a relatively low maximum Froude efficiency (approximately 0.5) and is mainly employed as a rudder for steering and in rapid swimming bouts (e.g. escape responses). Given this and the fact that bioinspired engineering designs are not obligated to wholly duplicate a biological model, computer chips were developed using a multilayer perception neural network model of undulatory fin propulsion in the knifefish Xenomystus nigri that would potentially allow an AUV to achieve high optimum values of propulsive efficiency at any given forward velocity, giving a minimum energy drain on the battery. We envisage that externally monitored information on flow velocity (sensory system) would be conveyed to the chips residing in the vehicle's control unit, which in turn would signal the locomotor unit to adopt kinematics (e.g. fin frequency, amplitude) associated with optimal propulsion efficiency. Power savings could protract vehicle operational life and/or provide more power to other functions (e.g. communications).

  20. Forecasting extreme wave events in moderate and high sea states

    NASA Astrophysics Data System (ADS)

    Magnusson, Anne Karin; Reistad, Magnar; Bitner-Gregersen, Elzbieta Maria

    2013-04-01

    Empirical studies on measurements have not yet come to conclusive relations between occurrence of rogue waves and - parameters which could be forecasted . Theoretical and tank experiments have demonstrated that high spectral peakedness and low spectral width combined (high Benjamin-Feir instability index, Onorato et al., 2006) give higher probability of rogue wave occurrence. Directional spread seems to reduce the probability of occurrence of rogue waves in these studies. Many years of experience with forecasting and discussions with people working in ocean environment indicate that rogue waves may as well occur in crossing seas. This was also indicated in a study in the Maxwave project (Toffoli et al., 2003) and the EXTREME SEAS project (Toffoli et al., 2011). We have here experimented with some indexes describing both high BFI and crossing seas and run the WAM model for some North Sea storm cases. Wave distributions measured at Ekofisk are analysed in the different cases. References • Onorato, M., Osborne, A., Serio, M., Cavaleri, L., Brandini, C., and Stansberg, C.: Extreme waves, modulational instability and second order theory: wave flume experiments on irregular waves,Europ. J. Mech. B/Fluids, 25, 586-601, 2006. • Toffoli, A., Lefevre, J.M., Monbaliu, J., Savina, H., and Bitner-Gregersen, E., "Freak Waves:Clues for Prediction in Ship Accidents?", Proc. ISOPE'2003 Conf. Hawai, USA, 2003. • Toffoli A., Bitner-Gregersen E. M., Osborne A. R., Serio M. Monbaliu J., Onorato M. (2011) Extreme Waves in Random Crossing Seas: Laboratory Experiments and Numerical Simulations. Geophys. Res. Lett., Vol. 38, L06605, 5 pp. doi: 10.1029/2011.