Science.gov

Sample records for air entrainment admixtures

  1. Investigation of Proprietary Air-Entraining Admixtures to Produce Frost- Resistant Concrete with Low Air Content

    DTIC Science & Technology

    1992-03-01

    given air content, a higher specific surface should result in a smaller spacing factor ( Mindess and Young 1981). Therefore, if a particular AEA produced...MS. Mindess , S., and Young, J. F. 1981. Concrete, Prentice-Hall, Englewood Cliffs, NJ. Powers, T. C. 1954 (May). "Void Spacing as a Basis for

  2. Air entrainment in hairy surfaces

    NASA Astrophysics Data System (ADS)

    Nasto, Alice; Regli, Marianne; Brun, P.-T.; Alvarado, José; Clanet, Christophe; Hosoi, A. E.

    2016-07-01

    Motivated by diving semiaquatic mammals, we investigate the mechanism of dynamic air entrainment in hairy surfaces submerged in liquid. Hairy surfaces are cast out of polydimethylsiloxane elastomer and plunged into a fluid bath at different velocities. Experimentally, we find that the amount of air entrained is greater than what is expected for smooth surfaces. Theoretically, we show that the hairy surface can be considered as a porous medium and we describe the air entrainment via a competition between the hydrostatic forcing and the viscous resistance in the pores. A phase diagram that includes data from our experiments and biological data from diving semiaquatic mammals is included to place the model system in a biological context and predict the regime for which the animal is protected by a plastron of air.

  3. Air entrainment by breaking waves

    NASA Astrophysics Data System (ADS)

    Deike, Luc; Lenain, Luc; Melville, W. Kendall

    2017-04-01

    We present an estimate of the total volume of entrained air by breaking waves in the open ocean, based on a model for a single breaking wave and the statistics of breaking waves measured in the field and described by the average length of breaking crests moving with speeds in the range (c,c + dc) per unit area of ocean surface, Λ(c)dc, introduced by Phillips (1985). By extending the single breaking wave model to the open ocean, we show that the volume flux of air entrained by breaking waves, VA (volume per unit ocean area per unit time, a velocity), is given by the third moment of Λ(c), modulated by a function of the wave slope. Using field measurements of the distribution Λ(c) and the wave spectrum, we obtain an estimate of the total volume flux of air entrained by breaking for a wide range of wind and wave conditions. These results pave the way for accurate remote sensing of the air entrained by breaking waves and subsequent estimates of the associated gas transfer.

  4. Entrainment Rate in Shallow Cumuli: Dependence on Entrained Dry Air Sources and Probability Density Functions

    NASA Astrophysics Data System (ADS)

    Lu, C.; Liu, Y.; Niu, S.; Vogelmann, A. M.

    2012-12-01

    In situ aircraft cumulus observations from the RACORO field campaign are used to estimate entrainment rate for individual clouds using a recently developed mixing fraction approach. The entrainment rate is computed based on the observed state of the cloud core and the state of the air that is laterally mixed into the cloud at its edge. The computed entrainment rate decreases when the air is entrained from increasing distance from the cloud core edge; this is because the air farther away from cloud edge is drier than the neighboring air that is within the humid shells around cumulus clouds. Probability density functions of entrainment rate are well fitted by lognormal distributions at different heights above cloud base for different dry air sources (i.e., different source distances from the cloud core edge). Such lognormal distribution functions are appropriate for inclusion into future entrainment rate parameterization in large scale models. To the authors' knowledge, this is the first time that probability density functions of entrainment rate have been obtained in shallow cumulus clouds based on in situ observations. The reason for the wide spread of entrainment rate is that the observed clouds are affected by entrainment mixing processes to different extents, which is verified by the relationships between the entrainment rate and cloud microphysics/dynamics. The entrainment rate is negatively correlated with liquid water content and cloud droplet number concentration due to the dilution and evaporation in entrainment mixing processes. The entrainment rate is positively correlated with relative dispersion (i.e., ratio of standard deviation to mean value) of liquid water content and droplet size distributions, consistent with the theoretical expectation that entrainment mixing processes are responsible for microphysics fluctuations and spectral broadening. The entrainment rate is negatively correlated with vertical velocity and dissipation rate because entrainment

  5. Response of entrained air-void systems in cement paste to pressure

    NASA Astrophysics Data System (ADS)

    Frazier, Robert

    2011-12-01

    Scope and Method of Study: Determine the response of entrained air-void systems in fresh cement paste to applied pressures by utilizing micro-computed tomography. Compare results to those suggested by the ASTM C231 Type B pressure meter calibration equations. Findings and Conclusions: The results of this research suggest that although the Type B pressure meter assumptions are valid for the compression of individual voids, the volume of air-voids which dissolve under pressure is significant enough to register noticeable errors when using a synthetic air-entraining admixture with the Type B pressure meter test. Results currently suggest that air-void systems with a significant percentage of small voids present will have higher deviation from the Boyle's Law model used by the Type B pressure meter due to the dissolution of these air-voids.

  6. Dry Air Entrainment into Hurricane Earl

    NASA Technical Reports Server (NTRS)

    Guillory, Anthony R.; Jedlovec, Gary J.; Atkinson, Robert J.; Hood, Robbie E.; LaFontaine, Frank J.

    2000-01-01

    Hurricane Earl formed in the Gulf of Mexico in September 1998. It quickly was upgraded from a tropical disturbance to tropical storm status and then to a hurricane. Earl possessed hybrid (tropical and extratropical) characteristics throughout its lifetime. The system maintained and erratic track, which led to wide variability in the operational track forecasts. It eventually made landfall on the Florida panhandle on 2 September and raced northeastward. During August and September 1998, NASA conducted the third Convection and Moisture Experiment (CAMEX-3). The experiment was focused on studying hurricanes with an emphasis toward developing a better understanding of their intensification and motion. Earl provides a unique opportunity to utilize high spatial and temporal resolution data collected from the DC-8 and high altitude ER-2 NASA platforms, which flew over Earl as it made landfall. These data can also be put into broader view provided by other instruments from the Geosychronous Operational Environmental Satellites (GOES) and the Tropical Rainfall Measuring Mission (TRMM) satellites. Hurricane Earl was affected by entrainment of dry air from the northwest. Hurricane Isis was intensifying and approaching the Mexican Pacific coast with its associated outflow potentially affecting the inflow into Earl as the storm neared Florida. In addition, a longwave synoptic trough circulation was present over the eastern U.S. Either or both of these could be responsible for the dry air into the system. This paper will focus on identifying the source of the dry by using upper-level wind and moisture fields derived from the GOES 6.7 um water vapor imagery. We will attempt to relate the large-scale observations to those from the NASA aircraft. An infrared instrument onboard the ER-2 also has a similar wavelength and may be able to confirm some of the GOES findings. In addition, a microwave radiometer with 4 channels focused on measuring precipitation and its associated ice

  7. Dry Air Entrainment into Hurricane Earl

    NASA Technical Reports Server (NTRS)

    Guillory, Anthony R.; Jedlovec, Gary J.; Atkinson, Robert J.; Hood, Robbie E.; LaFontaine, Frank J.

    2000-01-01

    Hurricane Earl formed in the Gulf of Mexico in September 1998. It quickly was upgraded from a tropical disturbance to tropical storm status and then to a hurricane. Earl possessed hybrid (tropical and extratropical) characteristics throughout its lifetime. The system maintained and erratic track, which led to wide variability in the operational track forecasts. It eventually made landfall on the Florida panhandle on 2 September and raced northeastward. During August and September 1998, NASA conducted the third Convection and Moisture Experiment (CAMEX-3). The experiment was focused on studying hurricanes with an emphasis toward developing a better understanding of their intensification and motion. Earl provides a unique opportunity to utilize high spatial and temporal resolution data collected from the DC-8 and high altitude ER-2 NASA platforms, which flew over Earl as it made landfall. These data can also be put into broader view provided by other instruments from the Geosychronous Operational Environmental Satellites (GOES) and the Tropical Rainfall Measuring Mission (TRMM) satellites. Hurricane Earl was affected by entrainment of dry air from the northwest. Hurricane Isis was intensifying and approaching the Mexican Pacific coast with its associated outflow potentially affecting the inflow into Earl as the storm neared Florida. In addition, a longwave synoptic trough circulation was present over the eastern U.S. Either or both of these could be responsible for the dry air into the system. This paper will focus on identifying the source of the dry by using upper-level wind and moisture fields derived from the GOES 6.7 um water vapor imagery. We will attempt to relate the large-scale observations to those from the NASA aircraft. An infrared instrument onboard the ER-2 also has a similar wavelength and may be able to confirm some of the GOES findings. In addition, a microwave radiometer with 4 channels focused on measuring precipitation and its associated ice

  8. Foam Generation and Air Entrainment Near a Free Surface

    DTIC Science & Technology

    1987-09-30

    plunging jets and by the action of turbulent eddies in water flowing over spillways has been discussed by several authors. Data for the entrained air flow...r = mean jet radius. 1 They determined the size of the region in the liquid which was affected by air entrainment and mea- sured the...Spilling Breaker," J. Fluid Mech., Vol. 63, 1. E.J. McKeogh and D.A. Ervine, 1981, " Air Entrainment Rate and Diffusion Pattern of Plunging Liquid

  9. Admixtures

    DTIC Science & Technology

    1970-07-01

    Evaluation of Home Solar Heating System gasadAtmtdDt ytm UCRL51 11/AT 54 pPC$.75MF$.00PB-250 867/PAT 54 p PC$4.50/MF$3.OO Developing Noiae Exposure...PB-251 266/PAT 61 p PC$4.50/MF$3.O0 Mining, Rubblization, and In Situ Retorting System Federal Funding of Civilian Revearch and Develop- for Deep Oil...vuli:;tb11.ity iith 3oi- r vwate.r ccontent (vvater rcduction). 3-3-hIn Tcorporatic-n of a system of e itrainod air voids in the cemient paste (air

  10. Study of Air Entrainment by a Horizontal Plunging Liquid Jet

    NASA Astrophysics Data System (ADS)

    Trujillo, Mario; Deshpande, Suraj; Wu, Xiongjun; Chahine, Georges

    2009-11-01

    The process of air entrainment following the impact of an initially horizontal circular water jet on a pool of water has been studied computationally and experimentally. It has been found that the entrainment of air cavities in the near field region is periodic, not continuous as reported in earlier studies. The simulations are based on a Volume-of-Fluid methodology with interfacial compression using a modified version of the open source utilities, OpenFoam. Close agreement with experiments is reported on the creation of cavities in the near field, where air entrainment occurs. The period of entrainment is found to be proportional to g, and a simplified closed-form solution for this periodic event is presented. An overall physical picture of the mechanisms leading to bubble formation is given. The far field, which is characterized by the presence of small bubbles is only partially resolved computationally. Comparisons against velocity data are performed in this region leading to adequate qualitative agreement.

  11. Maximal air bubble entrainment at liquid-drop impact.

    PubMed

    Bouwhuis, Wilco; van der Veen, Roeland C A; Tran, Tuan; Keij, Diederik L; Winkels, Koen G; Peters, Ivo R; van der Meer, Devaraj; Sun, Chao; Snoeijer, Jacco H; Lohse, Detlef

    2012-12-28

    At impact of a liquid drop on a solid surface, an air bubble can be entrapped. Here, we show that two competing effects minimize the (relative) size of this entrained air bubble: for large drop impact velocity and large droplets, the inertia of the liquid flattens the entrained bubble, whereas for small impact velocity and small droplets, capillary forces minimize the entrained bubble. However, we demonstrate experimentally, theoretically, and numerically that in between there is an optimum, leading to maximal air bubble entrapment. For a 1.8 mm diameter ethanol droplet, this optimum is achieved at an impact velocity of 0.25  m/s. Our results have a strong bearing on various applications in printing technology, microelectronics, immersion lithography, diagnostics, or agriculture.

  12. Using Ultrasound to Characterize Pulp Slurries with Entrained Air

    SciTech Connect

    Bamberger, Judith A.

    2006-08-06

    The development of fast and practical methods for inspecting fiber suspensions is of great interest in the paper making industry. For process control and paper quality prediction, several elements of the refining process during paper making must be accurately monitored, including specific fiber properties, weight percent fiber (composition), degree of refining, amount of solids, and entrained air content. The results of previous ultrasonic studies applied to wood pulp provide guidance that ultrasound attenuation is information rich, and it does potentially provide a tool for consistency measurement. Ultrasound has the ability to penetrate dense suspensions such as wood pulp slurries. It is has been shown, in some studies, that ultrasound is sensitive to degree of refining. The effects of entrained air, additives, the origin and treatment of the fibers do however all influence the measured data. A series of measurements were made with hardwood and softwood slurries to evaluate the ability of measuring pulp consistency, solids, and entrained air. The attenuation through the slurry was measured as the ultrasound travels from one transducer through the slurry to the other. The measurements identified the presence of entrained air in the pulp samples. To better understand the effects of air, measurements were made at increasing pressures to show how increased pressure reduced the amount of air observed in the spectrum.

  13. Entrainment.

    ERIC Educational Resources Information Center

    Carrier, Romance F.

    1978-01-01

    Presents a literature review including: (1) theoretical studies concerned with the development of methdology to determine the significance of entrainment effects to whale populations and ecosystems; and (2) site and laboratory studies. A list of 107 references drawn from the 1976 and 1977 literature is also presented. (HM)

  14. Effect of laminar air flow and clean-room dress on contamination rates of intravenous admixtures.

    PubMed

    Brier, K L; Latiolais, C J; Schneider, P J; Moore, T D; Buesching, W J; Wentworth, B C

    1981-08-01

    The effect of laminar air flow conditions and clean-room dress on the microbial contamination rates of intravenous admixtures was investigated. Intravenous admixtures were prepared by one investigator using aseptic technique under four environmental conditions: laminar air flow conditions with clean-room dress; laminar air flow without clean-room dress; clean table top with clean-room dress; and clean table top without clean-room dress. In each environmental condition, 350 admixtures were compounded. Negative-control samples (n = 150) were also tested, as were 10 positive-control samples. Samples were tested in each of two growth media and incubated at 35 degrees C for 14 days or until growth occurred. The incidence of contamination of admixtures compounded in laminar air flow conditions was significantly less than the contamination of those compounded on a clean table top (p less than 0.05) regardless of the operator's dress. The incidence of contamination of admixtures compounded while wearing clean-room dress was not significantly different from those prepared while not wearing clean-room dress regardless of the environment in which the admixture was prepared. The overall low level of contamination [0.79% (11/1400)] was inconclusive regarding the effect of dress on the incidence of contamination when admixtures were prepared under LAF conditions. It is concluded that, when one adheres to aseptic technique, the environment in which admixtures are compounded is the most important variable affecting the microbial contamination rate.

  15. Onset of air entrainment in laminar plunging jets

    NASA Astrophysics Data System (ADS)

    Cartellier, A.; Lasheras, J. C.

    1999-11-01

    A cylindrical jet impacting perpendicularly on a free surface is known to entrain air above a critical velocity. The question of the determination of the onset of air entainment has received a large attention, and various correlations are proposed in the litterature (see the review by Bin, Chem. Eng. Sc.- 1993). For jets free of any surface roughness, extensive data have been correlated by Lin and Donnelly (A.I.Ch.E. J. - 1965) leading to a widely accepted onset criteria of the form We = 10 Re^0.74 where the Weber and Reynolds numbers are defined on the jet characteristics at impact. However, this correlation fails for viscosities below 25cSt or Re above 1200. In addition, it cannot be extended to planar liquid sheets. Here, we revisit the question of the onset of air entrainment, and in particular the effect of the liquid properties such as viscosity and surface tension. Experiments have been conducted for viscous liquids and over a wide range of jet diameters. We propose a model which accounts both for the depression induced by the entrained flow field and for the viscous stresses at the interface generated by the acceleration of the liquid along the free surface. The onset of air entrainment expresses as a critical capillary number Ca versus the Morton number Mo =ρ^3 g ν^4 / σ^3 (one has Mo = (Ca/Rec)^2, where Rec is the Reynolds number based on the capillary length) and the ratio a/R of the capillary length to the jet radius. In the limit of large (respectivelly small) Morton numbers, Ca behaves as Mo^1/6 (respectivelly Mo^1/4) in agreement with the experiments. The dependency of Ca versus a/R will also be discussed.

  16. Freeze-Thaw Durability of Air-Entrained Concrete

    PubMed Central

    Shang, Huai-Shuai; Yi, Ting-Hua

    2013-01-01

    One of the most damaging actions affecting concrete is the abrupt temperature change (freeze-thaw cycles). The types of deterioration of concrete structures by cyclic freeze-thaw can be largely classified into surface scaling (characterized by the weight loss) and internal crack growth (characterized by the loss of dynamic modulus of elasticity). The present study explored the durability of concrete made with air-entraining agent subjected to 0, 100, 200, 300, and 400 cycles of freeze-thaw. The experimental study of C20, C25, C30, C40, and C50 air-entrained concrete specimens was completed according to “the test method of long-term and durability on ordinary concrete” GB/T 50082-2009. The dynamic modulus of elasticity and weight loss of specimens were measured after different cycles of freeze-thaw. The influence of freeze-thaw cycles on the relative dynamic modulus of elasticity and weight loss was analyzed. The findings showed that the dynamic modulus of elasticity and weight decreased as the freeze-thaw cycles were repeated. They revealed that the C30, C40, and C50 air-entrained concrete was still durable after 300 cycles of freeze-thaw according to the experimental results. PMID:23576906

  17. Air entrainment and the dynamics of volcanic jets and plumes

    NASA Astrophysics Data System (ADS)

    Mastin, L. G.; Solovitz, S.

    2008-12-01

    During a typical pyroclastic eruption, gas and pyroclasts exit a volcanic vent at speeds of tens to hundreds of meters per second. At the vent the mixture is negatively buoyant, and rises as a plinian column only if it ingests and heats sufficient air to attain positive buoyancy. As erosion increases vent radius r during an eruption, eruptive mass flux increases with r2, but the mass of air entrained increases only with r1. Hence the column ingests progressively less air relative to its mass and eventually, at some threshold mass flux m, collapses. The threshold mass flux m depends strongly on the air entrainment coefficient ɛ, i.e. the velocity of inrushing air normalized to the upward jet velocity. The value of ɛ is not well characterized in the near-vent region, and likely varies with vent geometry, overpressure, and jet density among other factors. Theoretical scaling relations suggest that a two-fold variation in ɛ (e.g. 0.05-0.10) results in a four-fold variation in m. Numerical models of overpressured jets show that near- vent entrainment may be inhibited by shock waves, promoting partial or oscillatory column collapse within an otherwise steady plinian column. Here we present the first results of laboratory experiments using particle image velocimetry to quantify near-vent air entrainment. In these experiments, we use a jet of compressed air seeded with 3 μm TiO2 tracer particles, exiting a vertically-directed pipe 1.27 cm in inside diameter and 18 cm long, with upstream pressures of 0 to 21 kPa, producing a pressure-balanced jet at the exit with velocities up to about 180 m s-1. The ambient air was seeded with tracer oil droplets a few micrometers in diameter from a fog machine. The seeded jet was illuminated by a 0.5 mm-thick Nd:YAG laser sheet that extended 5 cm above and horizontally from the vent. Particles illuminated by this sheet were photographed by pairs of images separated in time by 10 to 200 μs, from which we were able to extract flow

  18. The Effect of Solid Admixtures on the Velocity of Motion of a Free Dusty Air Jet

    NASA Technical Reports Server (NTRS)

    Chernov, A. P.

    1957-01-01

    In dusty air flows occurring in industrial practice in transport by air pressure of friable materials, in the drying, annealing, and so forth, of a pulverized solid mass in suspension, and in other processes, the concentration of solid particles usually has a magnitude of the order of 1 kg per 1 kg of air. At such a concentration, the ratio of the volume of the particles to the volume of the air is small (less than one-thousandth part). However, regardless of this, the presence of a solid admixture manifests itself in the rules for the velocity distribution of the air in a dusty air flow. As a result, the rules of velocity change are different for clean and for dusty air flows. The estimation of the influence of the admixture on the velocity of the motion of the flow presents a definitive interest. One of the attempts to estimate that influence on the axial velocity of a free axially symmetrical jet with admixtures was made by Abramovich. Abramovich assumed beforehand that the fine particles of the admixture in the jet are subject to the motion of the air (that is, that the velocity of the admixture is approximately equal to the local velocity of the air); he then took as the basis of his considerations, in solving the problem, the condition that the amount of motion of the two-phase jet must be constant.

  19. Hydrodynamics of air entrainment by moving contact lines

    NASA Astrophysics Data System (ADS)

    Chan, T. S.; Srivastava, S.; Marchand, A.; Andreotti, B.; Biferale, L.; Toschi, F.; Snoeijer, J. H.

    2013-07-01

    We study the dynamics of the interface between two immiscible fluids in contact with a chemically homogeneous moving solid plate. We consider the generic case of two fluids with any viscosity ratio and of a plate moving in either directions (pulled or pushed in the bath). The problem is studied by a combination of two models, namely, an extension to finite viscosity ratio of the lubrication theory and a Lattice Boltzmann method. Both methods allow to resolve, in different ways, the viscous singularity at the triple contact between the two fluids and the wall. We find a good agreement between the two models particularly for small capillary numbers. When the solid plate moves fast enough, the entrainment of one fluid into the other one can occur. The extension of the lubrication model to the case of a non-zero air viscosity, as developed here, allows us to study the dependence of the critical capillary number for air entrainment on the other parameters in the problem (contact angle and viscosity ratio).

  20. An experimental study of air entrainment and oxygen transfer at a water jet from a nozzle with air holes.

    PubMed

    Baylar, Ahmet; Emiroglu, M Emin

    2004-01-01

    An adequate supply of dissolved oxygen is important in natural rivers and in some water treatment processes. The dissolved oxygen concentration can be enhanced by entraining air bubbles in a receiving pool. When a water jet impinges a receiving pool at rest, air bubbles may be entrained and carried away below the pool free surface. This process is called plunging water jet entrainment and aeration. This paper describes an experimental study of the air entrainment rate and oxygen transfer efficiency of circular nozzles with and without air holes. In particular, the effect of varying the number, positions, and open/close status of the air holes is investigated. A negative pressure occurred depending on the air holes opened on the circular nozzles. This phenomenon affected the water jet expansion, water jet shape, air entrainment, and bubble penetration depth and, hence, the oxygen transfer efficiency. It was demonstrated that the air entrainment rate and the oxygen transfer efficiency of the circular nozzles with air holes were better than those of the circular nozzles without air holes. Therefore, adding air holes to a simple, circular nozzle could lead to a significantly increased air entrainment rate and oxygen transfer efficiency.

  1. Entrainment of Upper Level Dry Air into Hurricane Earl

    NASA Technical Reports Server (NTRS)

    Guillory, Anthony R.; Jedlovee, Gary J.; Hood, Robbie E.; Atkinson, Robert J.; LaFontaine, Frank J.

    2000-01-01

    Hurricane Earl developed from a tropical wave that moved into the Gulf of Mexico, which triggered abundant convection. On 1 Sept. 1998, the wave was upgraded directly to a tropical storm. Earl reached hurricane status the next morning. The system moved erratically as it interacted with an upper level short wave trough rotating around a long wave trough to the northeast. The storm made landfall near 0600 UTC on 3 September near Panama City, FL. During August and September 1998, NASA conducted the Third Convection and Moisture Experiment (CAMEX-3). It focused on studying the intensity, track, and impacts at landfall of hurricanes. On the afternoon of 2 September 1998, the NASA ER2 high-altitude aircraft flying at 65,000 feet in tandem with the NASA DC-8 flying at 35,000 feet flew over and through, respectively, the eastern rainbands of Earl near the Florida Panhandle as the storm neared landfall in the region. Two approaches to studying Earl are undertaken here: first, an examination of the source and height of the dry air region using GOES-8 water vapor data and, second, a look into the impact of the dry air entrainment on the system using aircraft remote sensing data.

  2. Air Entrainment in a Liquid Cell due to Fiber Drawing

    NASA Astrophysics Data System (ADS)

    Simpkins, P. G.; Kuck, V. J.

    1997-11-01

    Preliminary observations of air entrainment into a liquid bath of viscous Newtonian fluid are described. The motion generated by an optical fiber moving vertically through the bath gives rise to a free surface that is cusp-like. Photomicrographs of the contact region, however, illustrate that the free surface profile becomes conical with a small included angle that is draw speed dependent. There is some evidence to suggest that tip-streaming ( Taylor, G. I. 1934 The Formation of Emulsions in Definable Fields of Flow. Proc. Roy. Soc. Lond. A146, 501-523.) footnote Sherwood, J. D. 1984 Tip Streaming from Slender Drops in a Nonlinear Extensional Flow. J. Fluid Mech. 144, 281-295. filaments of air emanate from the contact zone to give rise to minute ( 10mm) bubbles via Rayleigh-Taylor instability. Continuous operation after the onset of tip-streaming results in the creation of larger bubbles from the small ones via coalescence during recirculation in the bath. Eventually the occurrence of very large bubbles can lead to break out and the absence of any coating on the fiber.

  3. Entrainment of Upper Level Dry Air Into Hurricane Earl

    NASA Technical Reports Server (NTRS)

    Guillory, Anthony R.; Jedlovec, Gary J.; Hood, Robbie E.; Atkinson, Robert J.; LaFontaine, Frank J.

    1999-01-01

    Hurricane Earl formed in the Gulf of Mexico in September 1998. It quickly was upgraded from a tropical disturbance to tropical storm status and then to a hurricane. Earl possessed hybrid (tropical and extratropical) characteristics throughout its lifetime. The system maintained and erratic track, which led to wide variability in the operational track forecasts. It eventually made landfall on the Florida panhandle on 2 September and raced northeastward. During August and September 1998, NASA conducted the third Convection and Moisture Experiment (CAMEX-3). The experiment was focused on studying hurricanes with an emphasis toward developing a better understanding of their intensification and motion. Earl provides a unique opportunity to utilize high spatial and temporal resolution data collected from the DC-8 and high altitude ER-2 NASA platforms, which flew over Earl as it made landfall. These data can also be put into broader view provided by other instruments from the Geosynchronous Operational Environmental Satellites (GOES) and the Tropical Rainfall Measuring Mission (TRMM) satellites. Hurricane Earl was affected by entrainment of dry air from the northwest. Hurricane Isis was intensifying and approaching the Mexican Pacific coast with its associated outflow potentially affecting the inflow into Earl as the storm neared Florida. In addition, a longwave synoptic trough circulation was present over the eastern U.S. Either or both of these could be responsible for the dry air into the system. This paper will focus on identifying the source of the dry by using upper-level wind and moisture fields derived from the GOES 6.7 um water vapor imagery. We will attempt to relate the large-scale observations to those from the NASA aircraft. An infrared instrument onboard the ER-2 also has a similar wavelength and may be able to confirm some of the GOES findings. In addition, a microwave radiometer with 4 channels focused on measuring precipitation and its associated ice

  4. Entrainment of Upper Level Dry Air Into Hurricane Earl

    NASA Technical Reports Server (NTRS)

    Guillory, Anthony R.; Jedlovec, Gary J.; Hood, Robbie E.; Atkinson, Robert J.; LaFontaine, Frank J.

    1999-01-01

    Hurricane Earl formed in the Gulf of Mexico in September 1998. It quickly was upgraded from a tropical disturbance to tropical storm status and then to a hurricane. Earl possessed hybrid (tropical and extratropical) characteristics throughout its lifetime. The system maintained and erratic track, which led to wide variability in the operational track forecasts. It eventually made landfall on the Florida panhandle on 2 September and raced northeastward. During August and September 1998, NASA conducted the third Convection and Moisture Experiment (CAMEX-3). The experiment was focused on studying hurricanes with an emphasis toward developing a better understanding of their intensification and motion. Earl provides a unique opportunity to utilize high spatial and temporal resolution data collected from the DC-8 and high altitude ER-2 NASA platforms, which flew over Earl as it made landfall. These data can also be put into broader view provided by other instruments from the Geosynchronous Operational Environmental Satellites (GOES) and the Tropical Rainfall Measuring Mission (TRMM) satellites. Hurricane Earl was affected by entrainment of dry air from the northwest. Hurricane Isis was intensifying and approaching the Mexican Pacific coast with its associated outflow potentially affecting the inflow into Earl as the storm neared Florida. In addition, a longwave synoptic trough circulation was present over the eastern U.S. Either or both of these could be responsible for the dry air into the system. This paper will focus on identifying the source of the dry by using upper-level wind and moisture fields derived from the GOES 6.7 um water vapor imagery. We will attempt to relate the large-scale observations to those from the NASA aircraft. An infrared instrument onboard the ER-2 also has a similar wavelength and may be able to confirm some of the GOES findings. In addition, a microwave radiometer with 4 channels focused on measuring precipitation and its associated ice

  5. Acoustic measurements of air entrainment by breaking waves

    NASA Astrophysics Data System (ADS)

    Terrill, Eric James

    1998-11-01

    Wave breaking at the surface of the ocean plays an important role in air-sea interaction processes. Bubbles entrained by breaking waves not only enhance the transfer of atmospheric gases to the ocean, but also modify the phase speed and attenuation of acoustic waves propagating through the bubbly medium. The development of acoustic instruments to measure bubbles and the results obtained from a number of field and laboratory experiments are presented. The first part of this dissertation addresses sound speed measurements made in the North Atlantic as part of the Acoustic Surface Reverberation Experiment (ASREX). An autonomous buoy system that directly measures the sound speed in the surface wave layer was developed. Data obtained with the instrument spanned several storm cycles with wind speeds and significant wave heights reaching 20 m/s and 8 m, respectively. The use of Wood's relation (1946) allows the calculation of the void fraction of air based on the low-frequency sound speed measurements. The highly variable near-surface sound speed/void fraction field is analyzed with respect to wind and surface wave- breaking parameters. The second part of this dissertation presents the development of a broadband acoustic technique which simultaneously measures the phase speed and attenuation at acoustic frequencies ranging from 4-100 kHz. The acoustic data is inverted for the size distribution of bubbles using algorithms that are based upon the physics of sound propagation through a bubbly mixture. This acoustic technique was evaluated in the large wave channel at the Hydraulics Laboratory, Scripps Institution of Oceanography, using mechanically generated breaking waves in seawater. Field measurements of bubble concentrations that result from wave breaking were made in both shallow water off Scripps Pier, California and in deep water near Point Conception, California using the broadband technique. Significant variability is observed in the bubble field, characterized by

  6. What's All the Talc About? Air Entrainment in Dilute Pyroclastic Density Currents

    NASA Astrophysics Data System (ADS)

    Marshall, B. J.; Andrews, B. J.; Fauria, K.

    2015-12-01

    A quantitative understanding of air entrainment is critical to predicting the behaviors of dilute Pyroclastic Density Currents (PDCs), including runout distance, liftoff, and mass fractionation into co-PDC plumes. We performed experiments in an 8.5x6x2.6 meter tank using 20 micron talc powder over a range of conditions to describe air entrainment as a function of temperature, duration and mass flux. The experiments are reproducible and are scaled with respect to the densimetric and thermal Richardson numbers (Ri and RiT), Froude number, thermal to kinetic energy density ratio (TEb/KE), Stokes number, and Settling number, such that they are dynamically similar to natural dilute PDCs. Experiments are illuminated with a swept laser sheet and imaged at 1000 Hz to create 3D reconstructions of the currents, with ~1-2 cm resolution, at up to 1.5 Hz. An array of 30 high-frequency thermocouples record the precise temperature in the currents at 3 Hz. Bulk entrainment rates are calculated based on measured current volumes, surface areas, temperatures and velocities. Entrainment rates vary from ~0-0.9 and do not show simple variation with TEb/KE, Ri, or RiT. Entrainment does, however, increase with decreasing eruption duration and increasing mass flux. Our results suggest that current heads entrain air more efficiently than current bodies (>0.5 compared to ~0.1). Because shorter duration currents have proportionally larger heads, their bulk entrainment rates are controlled by those heads, whereas longer duration currents are dominated by their bodies. Our experiments demonstrate that air entrainment, which exerts a fundamental control on PDC runout and liftoff, varies spatially and temporally within PDCs.

  7. PTV analysis of the entrained air into the diesel spray at high-pressure injection

    NASA Astrophysics Data System (ADS)

    Toda, Naoki; Yamashita, Hayato; Mashida, Makoto

    2014-08-01

    In order to clarify the effect of high-pressure injection on soot reduction in terms of the air entrainment into spray, the air flow surrounding the spray and set-off length indicating the distance from the nozzle tip to the flame region in diffusion diesel combustion were investigated using 300MPa injection of a multi-hole injector. The measurement of the air entrainment flow was carried out at non-evaporating condition using consecutive PTV (particle tracking velocimetry) method with a high-speed camera and a high-frequency pulse YAG laser. The set-off length was measured at highpressure and high-temperature using the combustion bomb of constant volume and optical system of shadow graph method. And the amount of air entrainment into spray until reaching set-off length in diffusion combustion was studied as a factor of soot formation.

  8. Effect of fast freeze-thaw cycles on mechanical properties of ordinary-air-entrained concrete.

    PubMed

    Shang, Huai-shuai; Cao, Wei-qun; Wang, Bin

    2014-01-01

    Freezing-thawing resistance is a very significant characteristic for concrete in severe environment (such as cold region with the lowest temperature below 0°C). In this study, ordinary-air-entrained (O-A-E) concrete was produced in a laboratory environment; the compressive strength, cubic compressive strength of C50, C40, C30, C25, and C20 ordinary-air-entrained concrete, tensile strength, and cleavage strength of C30 ordinary-air-entrained concrete were measured after fast freeze-thaw cycles. The effects of fast freeze-thaw cycles on the mechanical properties (compressive strength and cleavage strength) of ordinary-air-entrained concrete materials are investigated on the basis of the experimental results. And the concise mathematical formula between mechanical behavior and number of fast freeze-thaw cycles was established. The experiment results can be used as a reference in design, maintenance, and life prediction of ordinary-air-entrained concrete structure (such as dam, offshore platform, etc.) in cold regions.

  9. Effect of Fast Freeze-Thaw Cycles on Mechanical Properties of Ordinary-Air-Entrained Concrete

    PubMed Central

    Shang, Huai-shuai; Cao, Wei-qun; Wang, Bin

    2014-01-01

    Freezing-thawing resistance is a very significant characteristic for concrete in severe environment (such as cold region with the lowest temperature below 0°C). In this study, ordinary-air-entrained (O-A-E) concrete was produced in a laboratory environment; the compressive strength, cubic compressive strength of C50, C40, C30, C25, and C20 ordinary-air-entrained concrete, tensile strength, and cleavage strength of C30 ordinary-air-entrained concrete were measured after fast freeze-thaw cycles. The effects of fast freeze-thaw cycles on the mechanical properties (compressive strength and cleavage strength) of ordinary-air-entrained concrete materials are investigated on the basis of the experimental results. And the concise mathematical formula between mechanical behavior and number of fast freeze-thaw cycles was established. The experiment results can be used as a reference in design, maintenance, and life prediction of ordinary-air-entrained concrete structure (such as dam, offshore platform, etc.) in cold regions. PMID:24895671

  10. Quantification of hood effectiveness and entrained subsurface air in a Seattle Hospital

    SciTech Connect

    Dietz, R.N.; Goodrich, R.W.

    1994-05-01

    An underground 3-story wing of a hospital having problems with sewer air odors was tested with perfluorocarbon tracer (PFI) technology to quantify the performance of the mechanical ventilation system and determine the extent of sewer air entrainment and chemical hood effectiveness.

  11. Method and apparatus for preventing air pollution by the entrainment of particulate material

    SciTech Connect

    Walters, W.Z.

    1986-05-06

    A particulate material handling system is described which is capable of reducing the pollution of air by the entrainment of particulate solids. The system consists of: a covered elevated conveyor means from which the particulate material can be deposited to form a pile of that material in a designated area or to add to such a pile and air diversion means which is adapted to so cooperate with the conveyor as to prevent wind from entraining fines in the particulate material as it is dumped onto the pile or into the area and to prevent wind from stripping and entraining material from the pile by diverting the wind upwardly over the top of the elevated conveyor means and creating an eddy in the air on the leeward side of the pile of particulate material. Particulate material entrained in the air diverted over the elevated conveyor means will drop out of the air currents in the region where the eddy currents are formed and be deposited on the leeward side of the pile, the air diversion means being vertically oriented and adapted to extend lengthwise along at least the initial segment of the pile and essentially along the longitudinal centerline. The air diversion means have a lower edge which is adapted to be proximate to, in contact with, or buried in the pile depending on the height of the pile, and the conveyor being so constructed that it is capable of depositing particulate material on both sides of the air diversion means.

  12. Numerical simulations of transient air entrainment by rough and smooth plunging jets

    NASA Astrophysics Data System (ADS)

    Kiger, Ken; Kharoua, Nabil; Khezzar, Lyes

    2012-11-01

    Plunging jets are intimately linked to the process of air or gas entrainment into liquid pools, and can play either a beneficial or detrimental role in many environmental and industrial flows. The purpose of the present work is to assess the capability of combined LES/VOF algorithms to simulate water/air plunging jet flows, starting with the transient impact of the free jet, initial cavity formation, pinch off, and evolution towards a continuous entrainment phase. We focus on what happens in the transient impact phase for weakly and highly disturbed jets, operating with impact conditions of Re = UD / ν = 10 , 500 , We = ρU2 D / σ = 300 and Fr =U2 / gD = 83 . In particular, the study investigates the ability of the simulations to capture liquid surface instabilities and the influence of the exiting jet turbulence content on the entrainment behavior. The results indicate that the qualitative behavior of the entrainment process follows very closely what is observed in experiments, with the rough jet exhibiting surface instabilities at impact that are not present in the smooth jet. These have an effect on the development of the initial air cavity and interfacial area, leading to a doubling of the interfacial area for a nominally similar entrained volume of air.

  13. Air Entrainment and Thermal Evolution of Pyroclastic Density Currents at Tungurahua, Ecuador

    NASA Astrophysics Data System (ADS)

    Benage, M. C.; Dufek, J.; Mothes, P. A.

    2015-12-01

    The entrainment of air into pyroclastic density currents (PDCs) impacts the thermal profile and evolution of the current. However, the associated hazards and opaqueness of PDCs make it difficult to discern internal dynamics and entrainment through direct observations. In this work, we use a three-dimensional multiphase Eulerian-Eulerian-Lagrangian (EEL) model, deposit descriptions, and pyroclast field data, such as paleomagnetic and rind thickness, to study the entrainment efficiency and thus the thermal history of PDCs down the Juive Grande quebrada during the August 16-17th 2006 eruption of Tungurahua volcano. We conclude that 1) the efficient entrainment of ambient air cools the nose and upper portion of the PDCs by 30-60% of the original temperature, 2) PDCs with an initial temperature of 727 °C are on average more efficient at entraining ambient air than PDCs with an initial temperature of 327 °C, 3) the channelized PDCs develop a particle concentration gradient with a concentrated bed load region and suspended load region that leads to a large vertical temperature gradient, and 4) observations and pyroclast temperatures and textures suggest that the PDCs had temperatures greater than 327 °C in the bed load region while the upper, exterior portion of the currents cooled down to temperatures less than 100 °C. By combining field data and numerical models, the structure and dynamics of a PDC can be deduced for these relatively common small volume PDCs.

  14. Computational Study of Air Entrainment by Plunging Jets-Influence of Jet Inclination

    NASA Astrophysics Data System (ADS)

    Deshpande, Suraj; Trujillo, Mario

    2012-11-01

    The process of air entrainment by a continuous liquid jet plunging into a quiescent liquid pool is studied computationally. Our earlier study [APS2011] focused on shallow impacts and the discernible periodicity of air cavity formation. Here, we consider the effect of jet angle. For steep impacts, we see a chaotic formation of small cavities, in agreement with the literature. To explain the difference, we track evolution of the flow from initial impact to quasi-stationary state, for different jet inclinations. The initial impact always yields a large air cavity, regardless of jet angle. Difference emerges in the quasi-stationary state where shallow jets demonstrate the periodicity but the steep jets do not. We show that this is a manifestation of the air entrainment being a function of flow disturbance. For shallow jets, the disturbance originates from strong wavelike motion of the cavity which results in a total disruption of the jet. Thus, the resulting cavities are large and occur periodically. For the steep jets, entrainment happens by collapse of a thin gas film uniformly enshrouding the submerged jet. Such a thin film is very sensitive to the local flow disturbances. Thus, its collapse occurs stochastically all around the jet causing chaotic entrainment of small air pocket.

  15. Noninvasive CPAP with face mask: comparison among new air-entrainment masks and the Boussignac valve.

    PubMed

    Mistraletti, Giovanni; Giacomini, Matteo; Sabbatini, Giovanni; Pinciroli, Riccardo; Mantovani, Elena S; Umbrello, Michele; Palmisano, Debora; Formenti, Paolo; Destrebecq, Anne L L; Iapichino, Gaetano

    2013-02-01

    The performances of 2 noninvasive CPAP systems (high flow and low flow air-entrainment masks) were compared to the Boussignac valve in 3 different scenarios. Scenario 1: pneumatic lung simulator with a tachypnea pattern (tidal volume 800 mL at 40 breaths/min). Scenario 2: Ten healthy subjects studied during tidal breaths and tachypnea. Scenario 3: Twenty ICU subjects enrolled for a noninvasive CPAP session. Differences between set and effective CPAP level and F(IO(2)), as well as the lowest airway pressure and the pressure swing around the imposed CPAP level, were analyzed. The lowest airway pressure and swing were correlated to the pressure-time product (area of the airway pressure curve below the CPAP level) measured with the simulator. P(aO(2)) was a subject's further performance index. Lung simulator: Boussignac F(IO(2)) was 0.54, even if supplied with pure oxygen. The air-entrainment masks had higher swing than the Boussignac (P = .007). Pressure-time product correlated better with pressure swing (Spearman correlation coefficient [ρ] = 0.97) than with lowest airway pressure (ρ = 0.92). In healthy subjects, the high-flow air-entrainment mask showed lower difference between set and effective F(IO(2)) (P < .001), and lowest airway pressure (P < .001), compared to the Boussignac valve. In all measurements the Boussignac valve showed higher than imposed CPAP level (P < .001). In ICU subjects the high-flow mask had lower swing than the Boussignac valve (P = .03) with similar P(aO(2)) increase. High-flow air-entrainment mask showed the best performance in human subjects. During high flow demand, the Boussignac valve delivered lower than expected F(IO(2)) and showed higher dynamic hyper-pressurization than the air-entrainment masks. © 2013 Daedalus Enterprises.

  16. Experimental study of near-field air entrainment by subsonic volcanic jets

    USGS Publications Warehouse

    Solovitz, S.A.; Mastin, L.G.

    2009-01-01

    The flow structure in the developing region of a turbulent jet has been examined using particle image velocimetry methods, considering the flow at steady state conditions. The velocity fields were integrated to determine the ratio of the entrained air speed to the jet speed, which was approximately 0.03 for a range of Mach numbers up to 0.89 and. Reynolds numbers up to 217,000. This range of experimental Mach and Reynolds numbers is higher than previously considered for high-accuracy entrainment measures, particularly in the near-vent region. The entrainment values are below those commonly used for geophysical analyses of volcanic plumes, suggesting that existing 1-D models are likely to understate the tendency for column collapse. Copyright 2009 by the American Geophysical Union.

  17. Numerical simulations of air entrainment in a plunging jet of liquid

    NASA Astrophysics Data System (ADS)

    Brouilliot, Denis; Lubin, Pierre

    2013-11-01

    Air entrainment upon impact of a jet of liquid is a phenomenon present in wide variety of applications. We performed a series of two-dimensional simulations consisting in three different conditions of jet impingement and compared the results to experimental data. This study was first dedicated to the establishment of the numerical configuration and the setting of the injection parameters of the jet. We studied the dynamics of air entrainment by the jets impacting on the surface of the water in a tank, from the creation of the aerated cavities to the motion of the bubble plumes resulting from their deterioration of the cavities. The results concerned time-dependent and transient phenomena. To validate the simulations, we made several comparisons with experimental data, considering three angles of jet impact. Finally, we compared two numerical models for the free-surface description, using the most prevalent method in the literature and an original free-surface tracking method recently developed in our numerical tool. We showed that the formation of air cavities was similar for each condition and each numerical model, in agreement with the experimental results. Moreover, it was observed that the air entrainment had a different behavior depending on the conditions of jet impact.

  18. Air entrainment by a plunging liquid jet on a liquid pool

    NASA Astrophysics Data System (ADS)

    Liñan, Amable; Lasheras, Juan C.

    1999-11-01

    When a liquid jet impinges on liquid pool, with a velocity higher than a critical velocity, a thin air film is entrained by the jet. The thickness ha of the air film, and thus the air mass entrained by the jet, is a function of its radius a and velocity U. This function, for the realistic small values of the capillary number ɛ = μa U/σ << 1 (based on the air viscosity μa and surface tension σ) turns out to be of the form h_a/a = F(a/a_c, ɛ), where a_c=√ σ/ρl g is the capillary length (based on the acceleration of gravity and liquid density ρ_l). An analysis similar to the analysis of Levish and Landau, for the entrainment of liquid by a plate moving out of a liquid pool, shows that the dependence of h_a/a on ɛ is of the form h_a/a = ɛ^2/3f(a/a_c), where f is of order unity for a/ac << 1 and f ≈ a_c/a for large values of a_c/a

  19. Large Field of View PIV Measurements of Air Entrainment by SLS SMAT Water Sound Suppression System

    NASA Astrophysics Data System (ADS)

    Stegmeir, Matthew; Pothos, Stamatios; Bissell, Dan

    2015-11-01

    Water-based sound suppressions systems have been used to reduce the acoustic impact of space vehicle launches. Water flows at a high rate during launch in order to suppress Engine Generated Acoustics and other potentially damaging sources of noise. For the Space Shuttle, peak flow rates exceeded 900,000 gallons per minute. Such large water flow rates have the potential to induce substantial entrainment of the surrounding air, affecting the launch conditions and generating airflow around the launch vehicle. Validation testing is necessary to quantify this impact for future space launch systems. In this study, PIV measurements were performed to map the flow field above the SMAT sub-scale launch vehicle scaled launch stand. Air entrainment effects generated by a water-based sound suppression system were studied. Mean and fluctuating fluid velocities were mapped up to 1m above the test stand deck and compared to simulation results. Measurements performed with NASA MSFC.

  20. Material Properties Governing Co-Current Flame Spread: The Effect of Air Entrainment

    NASA Technical Reports Server (NTRS)

    Coutin, Mickael; Rangwala, Ali S.; Torero, Jose L.; Buckley, Steven G.

    2003-01-01

    A study on the effects of lateral air entrainment on an upward spreading flame has been conducted. The fuel is a flat PMMA plate of constant length and thickness but variable width. Video images and surface temperatures have allowed establishing the progression of the pyrolyis front and on the flame stand-off distance. These measurements have been incorporated into a theoretical formulation to establish characteristic mass transfer numbers ("B" numbers). The mass transfer number is deemed as a material related parameter that could be used to assess the potential of a material to sustain co-current flame spread. The experimental results show that the theoretical formulation fails to describe heat exchange between the flame and the surface. The discrepancies seem to be associated to lateral air entrainment that lifts the flame off the surface and leads to an over estimation of the local mass transfer number. Particle Image Velocimetry (PIV) measurements are in the process of being acquired. These measurements are intended to provide insight on the effect of air entrainment on the flame stand-off distance. A brief description of the methodology to be followed is presented here.

  1. Bending and growth of entrained air filament under converging and asymmetric rotational fields

    NASA Astrophysics Data System (ADS)

    Kumar, Parmod; Das, Arup K.; Mitra, Sushanta K.

    2017-02-01

    Here we have proposed the increase of the entrainment rate by extruding an air filament under the action of convergent but asymmetric rotational field. By varying the source speed and the diameter of rotational fields, we showed the bending of an air filament towards the higher strength direction of the asymmetric inertia. Interfacial profiles like bubble ejection from the air filament and non-collapsible entrainment with air accumulation in a stagnant zone are obtained in finite volume based numerical simulations, on gradual increase of average rotational fields. Physical understanding of bent interface profile reveals the presence of multiple stages in filament growth depending upon the inertia of surrounding medium. Accumulation of air in the stagnant zone is found to be more prominent in case of rotational speed based asymmetry in contrast to its counterpart having diametric asymmetry of imposing sources. Relative comparison between these two methods of producing asymmetric field showed faster growth of filament upon varying the source diameter, while keeping the speed same. In case of extreme retardation and enhancement of rotational asymmetry, film pinch off and formation of bubble train have been reported. The shape of ejected bubbles is governed by the inertia of the surrounding medium, and bubbles have taken elliptical shapes with their major axis aligned parallel to the adjacent velocity field.

  2. Failure Mechanisms of Air Entrainment in Drop Impact on Lubricated Surfaces

    NASA Astrophysics Data System (ADS)

    Pack, Min; Hu, Han; Kim, Dong-Ook; Zheng, Zhong; Stone, Howard; Sun, Ying; Drexel University Team; Princeton University Team

    2016-11-01

    Lubricated surfaces have recently been introduced and studied due to their potential benefit in various applications. Combining the techniques of total internal reflection microscopy and reflection interference microscopy, we examine the dynamics of an underlying air film upon drop impact on a lubricated substrate. In contrast to drop impact on solid surfaces where asperities cause random breakup of the entraining air film, we report two air film failure mechanisms on lubricated surfaces. In particular, using thin liquid films of high viscosity, we show that air film rupture shifts from a randomly driven to a controlled event. At low Weber numbers (We) the droplet bounces. At intermediate We, the air film fails at the center as the drop top surface crashes downward owing to impact-induced capillary waves; the resulting liquid-liquid contact time is found to be independent of We. In contrast, at high We, the air film failure occurs much earlier in time at the first inflection point of the air film shape away from the drop center, where the liquid-liquid van der Waals interactions become important. The predictable failure modes of the air film upon drop impact sheds light on droplet deposition in applications such as lubricant-infused self-cleaning surfaces. Support for this work was provided by the National Science Foundation under Grant No. CMMI-1401438 to Y.S.

  3. Dynamic Wetting in a Non-Equilibrium Gas: The Effect of Gas Pressure on Air Entrainment

    NASA Astrophysics Data System (ADS)

    Sprittles, James

    2014-11-01

    Experimentally, it is now well established that lowering the pressure of an ambient gas can suppress wetting failures, or ``air entrainment,'' at a liquid-solid-gas moving contact-line in both coating processes and drop impact dynamics. In this work, we consider the possibility that non-equilibrium effects in the gas are responsible for such phenomena. These can be included into a continuum framework by allowing for slip at both the solid-gas and liquid-gas interfaces, caused by Knudsen layers attached to these boundaries, which is related to the mean free path in the gas, and hence the ambient pressure. This model has been incorporated into a computational framework developed for dynamic wetting phenomena, which resolves all scales in the problem, so that these new effects can be investigated. It is shown that reductions in gas pressure, and hence increases in slip, can dramatically modify the flow field in the gas-film in front of a moving contact-line so that air entrainment is prevented. Specifically, in a dip-coating setup it is shown that the new model (a) describes experimental results for the critical wetting speed at a given gas pressure and (b) allows us to identify new parameters associated with the non-equilibrium gas dynamics which govern the contact-line's motion.

  4. Dynamical properties of breaking waves: dissipation, air entrainment and spray generation

    NASA Astrophysics Data System (ADS)

    Deike, Luc; Melville, W. Kendall; Popinet, Stephane

    2016-11-01

    Wave breaking in the ocean is of fundamental importance in order to quantify wave dissipation and air-sea interaction, including gas and momentum exchange, and to improve parametrization for ocean-atmosphere exchange in weather and climate models. Here, we present 2D and 3D direct numerical simulations of breaking waves, compared with laboratory measurements. The dissipation due to breaking in the 2D and 3D simulations is found to be in good agreement with experimental observations and inertial-scaling arguments. We discuss the transition from a 2D to a 3D flow during breaking. We present a model for air entrainment and bubble statistics that describes well the experimental and numerical data, and is based on turbulent fragmentation of the bubbles and a balance between buoyancy forces and viscous dissipation. Finally we discuss the generation of large drops during the impact and splashing process.

  5. Failure mechanisms of air entrainment in drop impact on lubricated surfaces.

    PubMed

    Pack, M; Hu, H; Kim, D; Zheng, Z; Stone, H A; Sun, Y

    2017-03-22

    Lubricated surfaces have recently been introduced and studied due to their potential benefit in various configurations and applications. Combining the techniques of total internal reflection microscopy and reflection interference microscopy, we examine the dynamics of an underlying air film upon drop impact on a lubricated substrate where the thin liquid film is immiscible to the drop. In contrast to drop impact on solid surfaces where even the smallest asperities cause random breakup of the entraining air film, we report two air film failure mechanisms on lubricated surfaces. In particular, using ≈5 μm thick liquid films of high viscosity, which should make the substrate nearly atomically smooth, we show that air film rupture shifts from asperity-driven to a controlled event. At low Weber numbers (We < 2, We = ρlU0(2)R/σ, U0 the impact velocity, R the drop radius, and ρl the density and σ the surface tension of the droplet) the droplet bounces. At intermediate We (2 < We < 10), the air film fails at the center as the top surface of the drop crashes downward owing to impact-induced capillary waves; the resulting liquid-liquid contact time is found to be independent of We. In contrast, at high We (We > 10), the air film failure occurs much earlier in time at the first inflection point of the air film shape away from the drop center, where the liquid-liquid van der Waals interactions become important. The predictable failure modes of the air film upon drop impact sheds light on droplet deposition in applications such as lubricant-infused self-cleaning surfaces.

  6. The effect of water temperature on air entrainment, bubble plumes, and surface foam in a laboratory breaking-wave analog

    NASA Astrophysics Data System (ADS)

    Callaghan, A. H.; Stokes, M. D.; Deane, G. B.

    2014-11-01

    Air-entraining breaking waves form oceanic whitecaps and play a key role in climate regulation through air-sea bubble-mediated gas transfer, and sea spray aerosol production. The effect of varying sea surface temperature on air entrainment, subsurface bubble plume dynamics, and surface foam evolution intrinsic to oceanic whitecaps has not been well studied. By using a breaking wave analog in the laboratory over a range of water temperatures (Tw = 5°C to Tw = 30°C) and different source waters, we have examined changes in air entrainment, subsurface bubble plumes, and surface foam evolution over the course of a breaking event. For filtered seawater, air entrainment was estimated to increase by 6% between Tw = 6°C and Tw = 30°C, driven by increases of about 43% in the measured surface roughness of the plunging water sheet. After active air entrainment, the rate of loss of air through bubble degassing was more rapid at colder water temperatures within the first 0.5 s of plume evolution. Thereafter, the trend reversed and bubbles degassed more quickly in warmer water. The largest observed temperature-dependent differences in subsurface bubble distributions occurred at radii greater than about 700 μm. Temperature-dependent trends observed in the subsurface bubble plume were mirrored in the temporal evolution of the surface whitecap foam area demonstrating the intrinsic link between surface whitecap foam and the subsurface bubble plume. Differences in foam and plume characteristics due to different water sources were greater than the temperature dependencies for the filtered seawater examined.

  7. Keeping warm with fur in cold water: entrainment of air in hairy surfaces

    NASA Astrophysics Data System (ADS)

    Nasto, Alice; Regli, Marianne; Brun, Pierre-Thomas; Clanet, Christophe; Hosoi, Anette

    2015-11-01

    Instead of relying on a thick layer of body fat for insulation as many aquatic mammals do, fur seals and otters trap air in their dense fur for insulation in cold water. Using a combination of model experiments and theory, we rationalize this mechanism of air trapping underwater for thermoregulation. For the model experiments, hairy surfaces are fabricated using laser cut molds and casting samples with PDMS. Modeling the hairy texture as a network of capillary tubes, the imbibition speed of water into the hairs is obtained through a balance of hydrostatic pressure and viscous stress. In this scenario, the bending of the hairs and capillary forces are negligible. The maximum diving depth that can be achieved before the hairs are wetted to the roots is predicted from a comparison of the diving speed and imbibition speed. The amount of air that is entrained in hairy surfaces is greater than what is expected for classic Landau-Levich-Derjaguin plate plunging. A phase diagram with the parameters from experiments and biological data allows a comparison of the model system and animals.

  8. Air entrainment and bubble statistics in three-dimensional breaking waves

    NASA Astrophysics Data System (ADS)

    Deike, Luc; Melville, W. K.; Popinet, Stephane

    2015-11-01

    Wave breaking in the ocean is of fundamental importance in order to quantify wave dissipation and air-sea interaction, including gas and momentum exchange, and to improve parametrizationsfor weather and climate models. Here, we investigate air entrainment and bubble statistics in three-dimensional breaking waves through direct numerical simulations of the two-phase air-water flow using the Open Source solver Gerris. As in previous 2D simulations, the dissipation due to breaking is found to be in good agreement with previous experimental observations and inertial-scaling arguments. For radii larger than the Hinze scale, the bubble size distribution, is found to follow a power law of the radius, r-3and to scale linearly with the time dependent turbulent dissipation rate during the active breaking stages. The time-averaged bubble size distribution is found to follow the same power law of the radius and to scale linearly with the wave dissipation rate per unit length of breaking crest. We propose a phenomenological turbulent bubble break-up model that describes the numerical results and existing experimental results.

  9. Laboratory air-entraining breaking waves: Imaging visible foam signatures to estimate energy dissipation

    NASA Astrophysics Data System (ADS)

    Callaghan, A. H.; Deane, G. B.; Stokes, M. D.

    2016-11-01

    Oceanic air-entraining breaking waves fundamentally influence weather and climate through bubble-mediated ocean-atmosphere exchanges, and influence marine engineering design by impacting statistics of wave heights, crest heights, and wave loading. However, estimating individual breaking wave energy dissipation in the field remains a fundamental problem. Using laboratory experiments, we introduce a new method to estimate energy dissipation by individual breaking waves using above-water images of evolving foam. The data show the volume of the breaking wave two-phase flow integrated in time during active breaking scales linearly with wave energy dissipated. To determine the volume time-integral, above-water images of surface foam provide the breaking wave timescale and horizontal extent of the submerged bubble plume, and the foam decay time provides an estimate of the bubble plume penetration depth. We anticipate that this novel remote sensing method will improve predictions of air-sea exchanges, validate models of wave energy dissipation, and inform ocean engineering design.

  10. Experimental and computational study and development of the bituminous coal entrained-flow air-blown gasifier for IGCC

    NASA Astrophysics Data System (ADS)

    Abaimov, N. A.; Osipov, P. V.; Ryzhkov, A. F.

    2016-10-01

    In the paper the development of the advanced bituminous coal entrained-flow air- blown gasifier for the high power integrated gasification combined cycle is considered. The computational fluid dynamics technique is used as the basic development tool. The experiment on the pressurized entrained-flow gasifier was performed by “NPO CKTI” JSC for the thermochemical processes submodel verification. The kinetic constants for Kuznetsk bituminous coal (flame coal), obtained by thermal gravimetric analysis method, are used in the model. The calculation results obtained by the CFD model are in satisfactory agreements with experimental data. On the basis of the verified model the advanced gasifier structure was suggested which permits to increase the hydrogen content in the synthesis gas and consequently to improve the gas turbine efficiency. In order to meet the specified requirements vapor is added on the second stage of MHI type gasifier and heat necessary for air gasification is compensated by supplemental heating of the blasting air.

  11. Experimental study on durability improvement of fly ash concrete with durability improving admixture.

    PubMed

    Quan, Hong-zhu; Kasami, Hideo

    2014-01-01

    In order to improve the durability of fly ash concrete, a series of experimental studies are carried out, where durability improving admixture is used to reduce drying shrinkage and improve freezing-thawing resistance. The effects of durability improving admixture, air content, water-binder ratio, and fly ash replacement ratio on the performance of fly ash concrete are discussed in this paper. The results show that by using durability improving admixture in nonair-entraining fly ash concrete, the compressive strength of fly ash concrete can be improved by 10%-20%, and the drying shrinkage is reduced by 60%. Carbonation resistance of concrete is roughly proportional to water-cement ratio regardless of water-binder ratio and fly ash replacement ratio. For the specimens cured in air for 2 weeks, the freezing-thawing resistance is improved. In addition, by making use of durability improving admixture, it is easier to control the air content and make fly ash concrete into nonair-entraining one. The quality of fly ash concrete is thereby optimized.

  12. Experimental Study on Durability Improvement of Fly Ash Concrete with Durability Improving Admixture

    PubMed Central

    Quan, Hong-zhu; Kasami, Hideo

    2014-01-01

    In order to improve the durability of fly ash concrete, a series of experimental studies are carried out, where durability improving admixture is used to reduce drying shrinkage and improve freezing-thawing resistance. The effects of durability improving admixture, air content, water-binder ratio, and fly ash replacement ratio on the performance of fly ash concrete are discussed in this paper. The results show that by using durability improving admixture in nonair-entraining fly ash concrete, the compressive strength of fly ash concrete can be improved by 10%–20%, and the drying shrinkage is reduced by 60%. Carbonation resistance of concrete is roughly proportional to water-cement ratio regardless of water-binder ratio and fly ash replacement ratio. For the specimens cured in air for 2 weeks, the freezing-thawing resistance is improved. In addition, by making use of durability improving admixture, it is easier to control the air content and make fly ash concrete into nonair-entraining one. The quality of fly ash concrete is thereby optimized. PMID:25013870

  13. Modeling variable density turbulence in the wake of an air-entraining transom stern

    NASA Astrophysics Data System (ADS)

    Hendrickson, Kelli; Yue, Dick

    2015-11-01

    This work presents a priori testing of closure models for the incompressible highly-variable density turbulent (IHVDT) flows in the near wake region of a transom stern. This three-dimensional flow is comprised of convergent corner waves that originate from the body and collide on the ship center plane forming the ``rooster tail'' that then widens to form the divergent wave train. These violent free-surface flows and breaking waves are characterized by significant turbulent mass flux (TMF) at Atwood number At = (ρ2 -ρ1) / (ρ2 +ρ1) ~ 1 for which there is little guidance in turbulence closure modeling for the momentum and scalar transport along the wake. To whit, this work utilizes high-resolution simulations of the near wake of a canonical three-dimensional transom stern using conservative Volume-of-Fluid (cVOF), implicit Large Eddy Simulation (iLES), and Boundary Data Immersion Method (BDIM) to capture the turbulence and large scale air entrainment. Analysis of the simulation results across and along the wake for the TMF budget and turbulent anisotropy provide the physical basis of the development of multiphase turbulence closure models. Performance of isotropic and anisotropic turbulent mass flux closure models will be presented. Sponsored by the Office of Naval Research.

  14. Three-dimensional flow observation on the air entrainment into a vertical-wet-pit pump

    NASA Astrophysics Data System (ADS)

    Hirata, K.; Maeda, T.; Nagura, T.; Inoue, T.

    2016-11-01

    The authors consider the air entrainment into a suction pipe which is vertically inserted down into a suction sump across a mean free-water surface. This configuration is often referred to as the “vertical wet-pit pump,” and has many practical advantages in construction, maintenance and operation. Most of the flows appearing in various industrial and environmental problems like the present suction- sump flow become often complicated owing to both of their unsteadiness with poor periodicity and their fully-three-dimensionality. In order to understand the complicated flow inside a suction sump in the vertical-wet-pit-pump configuration, the authors experimentally observe the flow using the three-dimensional particle tracking velocimetry (3D-PTV) technique, which includes more unknown factors in accuracy and reliability than other established measuring techniques. So, the authors examine the simultaneous measurement by the 3D-PTV with another velocimetry the ultrasonic velocity profiler. As a result, under the suitable condition with high accuracy, the authors have revealed the complicated flow.

  15. Downward flow of water with entrained air in a nonuniformaly heated subdivided annulus

    SciTech Connect

    Johnston, B.S.; May, C.P.

    1992-01-01

    This paper describes an experimental study in which water was fed to a vertical annulus, entraining air in downward flow. The annulus was subdivided by longitudinal fins into four subchannels and was heated with an azimuthally varying heat flux. A bypass was provided to simulate flow in parallel channels. For steady liquid flow, inlet temperature, and pressure boundary conditions, the power was increased until critical heat flux was reached. Overheating characteristics were grouped according to the prevailing flow pattern. In annular flows (j{sub L} < 0.3 m/s) overheating of the whole test section occurs when steam production causes countercurrent flooding. In intermittent flows (0.3 < j{sub L} < 0.9 m/s) the overheating is confined to a portion of the hot subchannel. The mechanism is postulated to be stagnation of a large bubble. In bubble flows (0.9 m/s < j{sub L}) overheating occurs by diverting inlet flow to the bypass and again involves the whole test section. Except at the very lowest flow rates, critical heat flux occurs when the effluent liquid temperature is below saturation.

  16. Downward flow of water with entrained air in a nonuniformaly heated subdivided annulus

    SciTech Connect

    Johnston, B.S.; May, C.P.

    1992-10-01

    This paper describes an experimental study in which water was fed to a vertical annulus, entraining air in downward flow. The annulus was subdivided by longitudinal fins into four subchannels and was heated with an azimuthally varying heat flux. A bypass was provided to simulate flow in parallel channels. For steady liquid flow, inlet temperature, and pressure boundary conditions, the power was increased until critical heat flux was reached. Overheating characteristics were grouped according to the prevailing flow pattern. In annular flows (j{sub L} < 0.3 m/s) overheating of the whole test section occurs when steam production causes countercurrent flooding. In intermittent flows (0.3 < j{sub L} < 0.9 m/s) the overheating is confined to a portion of the hot subchannel. The mechanism is postulated to be stagnation of a large bubble. In bubble flows (0.9 m/s < j{sub L}) overheating occurs by diverting inlet flow to the bypass and again involves the whole test section. Except at the very lowest flow rates, critical heat flux occurs when the effluent liquid temperature is below saturation.

  17. ENTRAINMENT MODELS

    EPA Science Inventory

    This presentation presented information on entrainment models. Entrainment models use entrainment hypotheses to express the continuity equation. The advantage is that plume boundaries are known. A major disadvantage is that the problems that can be solved are rather simple. The ...

  18. ENTRAINMENT MODELS

    EPA Science Inventory

    This presentation presented information on entrainment models. Entrainment models use entrainment hypotheses to express the continuity equation. The advantage is that plume boundaries are known. A major disadvantage is that the problems that can be solved are rather simple. The ...

  19. Leaching of concrete admixtures containing thiocyanate and resin acids.

    PubMed

    Andersson, A C; Stromvall, A M

    2001-02-15

    There is an increasing concern about the emission of pollutants during the construction and lifetime of buildings. The leaching of concrete admixtures containing thiocyanate and resin acids was studied using standard leaching tests and chemical analysis. Ecotoxicological risk was assessed for each admixture. Thiocyanate leaching from concrete, with a chlorine-free accelerating admixture, was determined by ion chromatography. Of the total amount of thiocyanate added, 6-8% was emitted within 30 d. The thiocyanate diffusion curve indicates a fast dissolution process from the surface layer, followed by a slower continuous diffusion process. Thiocyanate exhibits both acute and chronic toxicity, which makes it of immediate environmental concern. Resin acid leaching from concrete test specimens containing an admixture of air-entraining agents with tall oil was determined by solid-phase extraction, methylation, and GC/MS. Of added resin acids, 10% was emitted over 143 d. The leaching curves for the resin acids indicate a continuous diffusion that is proportional to the square root of time and follows Fick's first law of diffusion. The chemical composition of the resin acids in the leachate demonstrates degradation and rearrangement of the resin acids during diffusion. Resin acids emitted from concrete are of environmental concern because they are persistent and have the ability to bioaccumulate in aquatic organisms.

  20. Entrainment Heat Flux Computed with Lidar and Wavelet Technique in Buenos Aires During Last Chaitén Volcano Eruption

    NASA Astrophysics Data System (ADS)

    Pawelko, Ezequiel Eduardo; Salvador, Jacobo Omar; Ristori, Pablo Roberto; Pallotta, Juan Vicente; Otero, Lidia Ana; Quel, Eduardo Jaime

    2016-06-01

    At Lidar Division of CEILAP (CITEDEF-CONICET) a multiwavelength Raman-Rayleigh lidar optimized to measure the atmospheric boundary layer is being operated. This instrument is used for monitoring important aerosol intrusion events in Buenos Aires, such as the arrival of volcanic ashes from the Chaitén volcano eruption on May 2008. That was the first monitoring of volcanic ash with lidar in Argentina. In this event several volcanic ash plumes with high aerosol optical thickness were detected in the free atmosphere, affecting the visibility, surface radiation and therefore, the ABL evolution. In this work, the impact of ashes in entrainment flux ratio is studied. This parameter is obtained from the atmospheric boundary layer height and entrainment zone thickness using algorithms based on covariance wavelet transform.

  1. Two-phase numerical study of the flow field formed in water pump sump: influence of air entrainment

    NASA Astrophysics Data System (ADS)

    Bayeul-Lainé, A. C.; Simonet, S.; Bois, G.; Issa, A.

    2012-11-01

    In a pump sump it is imperative that the amount of non-homogenous flow and entrained air be kept to a minimum. Free air-core vortex occurring at a water-intake pipe is an important problem encountered in hydraulic engineering. These vortices reduce pump performances, may have large effects on the operating conditions and lead to increase plant operating costs.This work is an extended study starting from 2006 in LML and published by ISSA and al. in 2008, 2009 and 2010. Several cases of sump configuration have been numerically investigated using two specific commercial codes and based on the initial geometry proposed by Constantinescu and Patel. Fluent and Star CCM+ codes are used in the previous studies. The results, obtained with a structured mesh, were strongly dependant on main geometrical sump configuration such as the suction pipe position, the submergence of the suction pipe on one hand and the turbulence model on the other hand. Part of the results showed a good agreement with experimental investigations already published. Experiments, conducted in order to select best positions of the suction pipe of a water-intake sump, gave qualitative results concerning flow disturbances in the pump-intake related to sump geometries and position of the pump intake. The purpose of this paper is to reproduce the flow pattern of experiments and to confirm the geometrical parameter that influences the flow structure in such a pump. The numerical model solves the Reynolds averaged Navier-Stokes (RANS) equations and VOF multiphase model. STAR CCM+ with an adapted mesh configuration using hexahedral mesh with prism layer near walls was used. Attempts have been made to calculate two phase unsteady flow for stronger mass flow rates and stronger submergence with low water level in order to be able to capture air entrainment. The results allow the knowledge of some limits of numerical models, of mass flow rates and of submergences for air entrainment. In the validation of this

  2. [Characteristic of toxic risks of air pollution by chemical admixtures aboard the piloted orbital stations].

    PubMed

    Mukhamedieva, L N; Bogomolov, V V

    2009-01-01

    Trends in the chemical composition of air revealed by the sanitary-chemical and toxicological investigations in multifactorial ground-based tests and long-term space flights aboard the Salyut- 6, 7, Mir and the International space station have been used to deduce the chemical characteristic and to substantiate methods to and criteria for evaluation of toxic risks to space crews from air chemical pollution. Of particular concern were the toxic risks and crew protection during the first ingress to modules on the stage of station assembly in orbit, in the course of long-term missions, and in the event of acute exposure in off-nominal and emergency conditions.

  3. Entrainment of stratospheric air and Asian pollution by the convective boundary layer in the southwestern U.S.

    NASA Astrophysics Data System (ADS)

    Langford, A. O.; Alvarez, R. J.; Brioude, J.; Fine, R.; Gustin, M. S.; Lin, M. Y.; Marchbanks, R. D.; Pierce, R. B.; Sandberg, S. P.; Senff, C. J.; Weickmann, A. M.; Williams, E. J.

    2017-01-01

    A series of deep stratospheric intrusions in late May 2013 increased the daily maximum 8 h surface ozone (O3) concentrations to more than 70 parts per billion by volume (ppbv) at rural and urban surface monitors in California and Nevada. This influx of ozone-rich lower stratospheric air and entrained Asian pollution persisted for more than 5 days and contributed to exceedances of the 2008 8 h national ambient air quality standard of 75 ppbv on 21 and 25 May in Clark County, NV. Exceedances would also have occurred on 22 and 23 May had the new standard of 70 ppbv been in effect. In this paper, we examine this episode using lidar measurements from a high-elevation site on Angel Peak, NV, and surface measurements from NOAA, the Clark County, Nevada Department of Air Quality, the Environmental Protection Agency Air Quality System, and the Nevada Rural Ozone Initiative. These measurements, together with analyses from the National Centers for Environmental Prediction/North American Regional Reanalysis; NOAA Geophysical Fluid Dynamics Laboratory AM3 model; NOAA National Environmental Satellite, Data, and Information Service Real-time Air Quality Modeling System; and FLEXPART models, show that the exceedances followed entrainment of 20 to 40 ppbv of lower stratospheric ozone mingled with another 0 to 10 ppbv of ozone transported from Asia by the unusually deep convective boundary layers above the Mojave desert. Our analysis suggests that this vigorous mixing can affect both high and low elevations and help explain the springtime ozone maximum in the southwestern U.S.

  4. Effect of an entrained air bubble on the acoustics of an ink channel.

    PubMed

    Jeurissen, Roger; de Jong, Jos; Reinten, Hans; van den Berg, Marc; Wijshoff, Herman; Versluis, Michel; Lohse, Detlef

    2008-05-01

    Piezo-driven inkjet systems are very sensitive to air entrapment. The entrapped air bubbles grow by rectified diffusion in the ink channel and finally result in nozzle failure. Experimental results on the dynamics of fully grown air bubbles are presented. It is found that the bubble counteracts the pressure buildup necessary for the droplet formation. The channel acoustics and the air bubble dynamics are modeled. For good agreement with the experimental data it is crucial to include the confined geometry into the model: The air bubble acts back on the acoustic field in the channel and thus on its own dynamics. This two-way coupling limits further bubble growth and thus determines the saturation size of the bubble.

  5. Size distribution of oceanic air bubbles entrained in sea-water by wave-breaking

    NASA Technical Reports Server (NTRS)

    Resch, F.; Avellan, F.

    1982-01-01

    The size of oceanic air bubbles produced by whitecaps and wave-breaking is determined. The production of liquid aerosols at the sea surface is predicted. These liquid aerosols are at the origin of most of the particulate materials exchanged between the ocean and the atmosphere. A prototype was designed and built using an optical technique based on the principle of light scattering at an angle of ninety degrees from the incident light beam. The output voltage is a direct function of the bubble diameter. Calibration of the probe was carried out within a range of 300 microns to 1.2 mm. Bubbles produced by wave-breaking in a large air-sea interaction simulating facility. Experimental results are given in the form of size spectrum.

  6. Numerical investigation of a turbulent hydraulic jump: Interface statistics and air entrainment

    NASA Astrophysics Data System (ADS)

    Mortazavi, Milad; Kim, Dokyun; Mani, Ali; Moin, Parviz

    2011-11-01

    The objective of this study is to develop an understanding of formation of bubbles due to turbulence/interface interactions and nonlinear surface wave phenomena. As a model problem a statistically stationary turbulent hydraulic jump has been considered. Turbulent hydraulic jump with an inflow Froude number of 2 and Reynolds number of 88000-based on inflow height-has been numerically simulated. Based on typical air- water systems, a density ratio of 831 has been selected for our calculations. A refined level-set method is employed to track the detailed dynamics of the interface evolution. Comparison of flow statistics with experimental results of Murzyn et al. (Int. J. Multiphase Flow, 2005) will be presented. The probability density function of principal curvatures of the air- water interface and curvature distribution patterns in the chaotic regions are investigated. The importance of liquid impact events in bubble generation will be discussed. Supported by the Office of Naval Research, with Dr. Pat Purtell, program manager.

  7. Airborne & SAR Synergy Reveals the 3D Structure of Air Bubble Entrainment in Internal Waves and Frontal Zones

    NASA Astrophysics Data System (ADS)

    da Silva, J. C. B.; Magalhaes, J. M.; Batista, M.; Gostiaux, L.; Gerkema, T.; New, A. L.

    2013-03-01

    Internal waves are now recognised as an important mixing mechanism in the ocean. Mixing at the base of the mixed layer and in the seasonal thermocline affects the properties of those water masses which define the exchange of heat and freshwater between the atmosphere and ocean. The breaking of Internal Solitary Waves (ISWs) contributes significantly to turbulent mixing in the near-surface layers, through the continual triggering of instabilities as they propagate and shoal towards the coast or shallow topography. Here we report some results of the EU funded project A.NEW (Airborne observations of Nonlinear Evolution of internal Waves generated by internal tidal beams). The airborne capabilities to observe small scale structure of breaking internal waves in the near-shore zone has been demonstrated in recent studies (e.g. Marmorino et al., 2008). In particular, sea surface thermal signatures of shoaling ISWs have revealed the turbulent character of these structures in the form of surface “boil” features. On the other hand, some in situ measurements of internal waves and theoretical work suggest subsurface entrainment of air bubbles in the convergence zones of ISWs (Serebryany and Galybin, 2009; Grimshaw et al., 2010). We conducted airborne remote sensing observations in the coastal zone off the west Iberian Peninsula (off Lisbon, Portugal) using high resolution imaging sensors: LiDAR (Light Detection And Ranging), hyperspectral cameras (Eagle and Hawk) and thermal infrared imaging (TABI-320). These measurements were planned based on previous SAR observations in the region, which included also near-real time SAR overpasses (ESA project AOPT-2423 and TerraSAR-X project OCE-0056). The airborne measurements were conducted from board the NERC (Natural Environmental Research Centre) Do 228 aircraft in the summer of 2010. The TABI-320 thermal airborne broadband imager can distinguish temperature differences as small as one-twentieth of a degree and operates in the

  8. Performance of rice husk ash produced using a new technology as a mineral admixture in concrete

    SciTech Connect

    Nehdi, M.; Duquette, J.; El Damatty, A

    2003-08-01

    This article investigates the use of a new technique for the controlled combustion of Egyptian rice husk to mitigate the environmental concerns associated with its uncontrolled burning and provide a supplementary cementing material for the local construction industry. The reactor used provides efficient combustion of rice husk in a short residency time via the suspension of processed particles by jets of a process air stream that is forced though stationary angled blades at high velocity. Investigations on the rice husk ash (RHA) thus produced included oxide analysis, X-ray diffraction, carbon content, grindability, water demand, pozzolanic activity index, surface area, and particle size distribution measurements. In addition, concrete mixtures incorporating various proportions of silica fume (SF) and Egyptian RHA (EG-RHA) produced at different combustion temperatures were made and compared. The workability, superplasticizer and air-entraining admixture requirements, and compressive strength at various ages of these concrete mixtures were evaluated, and their resistance to rapid chloride penetrability and deicing salt surface scaling were examined. Test results indicate that contrary to RHA produced using existing technology, the superplasticizer and air-entraining agent requirements did not increase drastically when the RHA developed in this study was used. Compressive strengths achieved by concrete mixtures incorporating the new RHA exceeded those of concretes containing similar proportions of SF. The resistance to surface scaling of RHA concrete was better than that of concrete containing similar proportions of SF. While the chloride penetrability was substantially decreased by RHA, it remained slightly higher than that achieved by SF concrete.

  9. ENTRAINMENT BY LIGAMENT-CONTROLLED EFFERVESCENT ATOMIZER-PRODUCED SPRAYS

    EPA Science Inventory

    Entrainment of ambient air into sprays produced by a new type of effervescent atomizer is reported. Entrainment data were obtained using a device similar to that described by Ricou & Spalding (1961). Entrainment data were analyzed using the model of Bush & Sojka (1994), in concer...

  10. ENTRAINMENT BY LIGAMENT-CONTROLLED EFFERVESCENT ATOMIZER-PRODUCED SPRAYS

    EPA Science Inventory

    Entrainment of ambient air into sprays produced by a new type of effervescent atomizer is reported. Entrainment data were obtained using a device similar to that described by Ricou & Spalding (1961). Entrainment data were analyzed using the model of Bush & Sojka (1994), in concer...

  11. Non-dispersive atomic-fluorescence spectrometry of trace amounts of bismuth by introduction of its gaseous hydride into a premixed argon (entrained air)-hydrogen flame.

    PubMed

    Kobayashi, S; Nakahara, T; Musha, S

    1979-10-01

    A method has been developed for the determination of bismuth by generation of its gaseous hydride and introduction of the hydride into a premixed argon (entrained air)-hydrogen flame, the atomic-fluorescence lines from which are all detected by use of a non-dispersive system. The detection limit is 5 pg/ml, or 0.1 ng of bismuth, but the reagent blank found in a 20-ml sample volume was approximately 2 ng of bismuth. Analytical working curves obtained by measuring peak-heights and integrated peak-areas of the signals are linear over a range of about four orders of magnitude from the detection limit. Perchloric, phosphoric and sulphuric acids up to 2.0M concentration give no interference, but nitric acid gives slight depression of the signal. The presence of silver, gold, nickel, palladium, platinum, selenium and tellurium in 1000-fold ratio to bismuth causes pronounced depression of the signal, whereas mercury and tin slightly enhance the atomic-fluorescence signal. The method has been applied to the determination of bismuth in aluminium-base alloys and sulphide ores with use of the standard additions method. The results are in good agreement with those obtained by flame atomic-absorption spectrometry and optical emission spectrometry with an inductively coupled plasma.

  12. Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium.

    PubMed

    Zhou, Ying; Qiu, Hongxiang; Xu, Shuhua

    2017-02-23

    Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations.

  13. Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium

    PubMed Central

    Zhou, Ying; Qiu, Hongxiang; Xu, Shuhua

    2017-01-01

    Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations. PMID:28230170

  14. Mesler entrainment in alcohols

    NASA Astrophysics Data System (ADS)

    Sundberg-Anderson, R. K.; Saylor, J. R.

    2014-01-01

    Mesler entrainment has been studied extensively in water and, more recently, in silicone oils. Studies of Mesler entrainment in liquids other than these are rare. The extant experimental results in water show significant irreproducibility both in the qualitative characteristics of Mesler entrainment and in the existence or nonexistence of Mesler entrainment when, for example, drops of the same diameter are released from the same height. In contrast, in silicone oils, Mesler entrainment is highly reproducible, essentially occurring either all of the time, or none of the time for a given set of conditions. A goal of the present work was to determine which of these two behaviors is the "standard" behavior—that is, to determine whether Mesler entrainment is typically repeatable or not. The experimental studies presented herein were conducted in three liquids that have not been the subject of detailed investigation to date: ethyl alcohol, isopropyl alcohol, and methyl alcohol. All of these alcohol results showed behavior very similar to that observed in silicone oils, suggesting that Mesler entrainment is typically repeatable and that water is an atypical fluid, causing irreproducible results. Additionally, we present data obtained in silicone oils and combine that with the alcohol data in an attempt to develop a combination of dimensionless groups that predicts the boundaries within which Mesler entrainment occurs for liquids other than water.

  15. Cloud-Top Entrainment in Stratocumulus Clouds

    NASA Astrophysics Data System (ADS)

    Mellado, Juan Pedro

    2017-01-01

    Cloud entrainment, the mixing between cloudy and clear air at the boundary of clouds, constitutes one paradigm for the relevance of small scales in the Earth system: By regulating cloud lifetimes, meter- and submeter-scale processes at cloud boundaries can influence planetary-scale properties. Understanding cloud entrainment is difficult given the complexity and diversity of the associated phenomena, which include turbulence entrainment within a stratified medium, convective instabilities driven by radiative and evaporative cooling, shear instabilities, and cloud microphysics. Obtaining accurate data at the required small scales is also challenging, for both simulations and measurements. During the past few decades, however, high-resolution simulations and measurements have greatly advanced our understanding of the main mechanisms controlling cloud entrainment. This article reviews some of these advances, focusing on stratocumulus clouds, and indicates remaining challenges.

  16. Entraining gravity currents

    NASA Astrophysics Data System (ADS)

    Johnson, Chris; Hogg, Andrew

    2012-11-01

    Large-scale gravity currents, such as those formed when industrial effluent is discharged at sea, are greatly affected by the entrainment and mixing of ambient fluid into the current, which both dilutes the flow and causes an effective drag between the current and ambient. We study these currents theoretically by combining a shallow-water model for gravity currents flowing under a deep ambient with an empirical model for entrainment, and seek long-time similarity solutions of this model. We find that the dependence of entrainment on the bulk Richardson number plays a crucial role in the current dynamics, and results in entrainment occurring mainly in a region close to the flow front, reminiscent of the entraining current `head' observed in natural flows. The long-time solution of an entraining lock-release current is a similarity solution of the second kind, in which the current grows as a power of time that is dependent on the form of the entrainment model, approximately as t 0 . 44. The structure of a current driven by a constant buoyancy flux is quite different, with the current length growing as t 4 / 5. Scaling arguments suggest that these solutions are reached only at very long times, and so may be attained in large natural flows, but not in small-scale experiments.

  17. The art of entrainment.

    PubMed

    Roenneberg, Till; Daan, Serge; Merrow, Martha

    2003-06-01

    The circadian system actively synchronizes the temporal sequence of biological functions with the environment. The oscillatory behavior of the system ensures that entrainment is not passive or driven and therefore allows for great plasticity and adaptive potential. With the tools at hand, we now can concentrate on the most important circadian question: How is the complex task of entrainment achieved by anatomical, cellular, and molecular components? Understanding entrainment is equal to understanding the circadian system. The results of this basic research will help us to understand temporal ecology and will allow us to improve conditions for humans in industrialized societies.

  18. Increasing jet entrainment, mixing and spreading

    DOEpatents

    Farrington, Robert B.

    1994-01-01

    A free jet of air is disturbed at a frequency that substantially matches natural turbulences in the free jet to increase the entrainment, mixing, and spreading of air by the free jet, for example in a room or other enclosure. The disturbances are created by pulsing the flow of air that creates the free jet at the desired frequency. Such pulsing of the flow of air can be accomplished by sequentially occluding and opening a duct that confines and directs the flow of air, such as by rotating a disk on an axis transverse to the flow of air in the duct.

  19. Increasing jet entrainment, mixing and spreading

    DOEpatents

    Farrington, R.B.

    1994-08-16

    A free jet of air is disturbed at a frequency that substantially matches natural turbulences in the free jet to increase the entrainment, mixing, and spreading of air by the free jet, for example in a room or other enclosure. The disturbances are created by pulsing the flow of air that creates the free jet at the desired frequency. Such pulsing of the flow of air can be accomplished by sequentially occluding and opening a duct that confines and directs the flow of air, such as by rotating a disk on an axis transverse to the flow of air in the duct. 11 figs.

  20. An observational study of entrainment rate in deep convection

    DOE PAGES

    Guo, Xiaohao; Lu, Chunsong; Zhao, Tianliang; ...

    2015-09-22

    This study estimates entrainment rate and investigates its relationships with cloud properties in 156 deep convective clouds based on in-situ aircraft observations during the TOGA-COARE (Tropical Ocean Global Atmosphere Coupled Ocean Atmosphere Response Experiment) field campaign over the western Pacific. To the authors’ knowledge, this is the first study on the probability density function of entrainment rate, the relationships between entrainment rate and cloud microphysics, and the effects of dry air sources on the calculated entrainment rate in deep convection from an observational perspective. Results show that the probability density function of entrainment rate can be well fitted by lognormal,more » gamma or Weibull distribution, with coefficients of determination being 0.82, 0.85 and 0.80, respectively. Entrainment tends to reduce temperature, water vapor content and moist static energy in cloud due to evaporative cooling and dilution. Inspection of the relationships between entrainment rate and microphysical properties reveals a negative correlation between volume-mean radius and entrainment rate, suggesting the potential dominance of homogeneous mechanism in the clouds examined. The entrainment rate and environmental water vapor content show similar tendencies of variation with the distance of the assumed environmental air to the cloud edges. Their variation tendencies are non-monotonic due to the relatively short distance between adjacent clouds.« less

  1. An observational study of entrainment rate in deep convection

    SciTech Connect

    Guo, Xiaohao; Lu, Chunsong; Zhao, Tianliang; Zhang, Guang Jun; Liu, Yangang

    2015-09-22

    This study estimates entrainment rate and investigates its relationships with cloud properties in 156 deep convective clouds based on in-situ aircraft observations during the TOGA-COARE (Tropical Ocean Global Atmosphere Coupled Ocean Atmosphere Response Experiment) field campaign over the western Pacific. To the authors’ knowledge, this is the first study on the probability density function of entrainment rate, the relationships between entrainment rate and cloud microphysics, and the effects of dry air sources on the calculated entrainment rate in deep convection from an observational perspective. Results show that the probability density function of entrainment rate can be well fitted by lognormal, gamma or Weibull distribution, with coefficients of determination being 0.82, 0.85 and 0.80, respectively. Entrainment tends to reduce temperature, water vapor content and moist static energy in cloud due to evaporative cooling and dilution. Inspection of the relationships between entrainment rate and microphysical properties reveals a negative correlation between volume-mean radius and entrainment rate, suggesting the potential dominance of homogeneous mechanism in the clouds examined. The entrainment rate and environmental water vapor content show similar tendencies of variation with the distance of the assumed environmental air to the cloud edges. Their variation tendencies are non-monotonic due to the relatively short distance between adjacent clouds.

  2. Investigation of Proprietary Admixtures. Report 2. 1977-1978 Tests.

    DTIC Science & Technology

    1980-01-01

    proprietary admixtures obtained for this investigation were described as follows: a. SM-10-77 is a condensation product of melamine and formaldehyde . b. SM-1...78 is a sulfonated naphthalene formaldehyde condensate. c. SM-5-79 is an aqueous solution of a modified naphthalene sulfonate . Mixtures 9. Air

  3. Entrainment by Lazy Plumes

    NASA Astrophysics Data System (ADS)

    Kaye, Nigel; Hunt, Gary

    2004-11-01

    We consider plumes with source conditions that have a net momentum flux deficit compared to a pure plume - so called lazy plumes. We examine both the case of constant buoyancy flux and buoyancy flux linearly increasing with height. By re-casting the plume conservation equations (Morton, Taylor & Turner 1956) for a constant entrainment coefficient ((α)) in terms of the plume radius (β) and the dimensionless parameter (Γ=frac5Q^2 B4α M^5/2) we show that the far-field flow in a plume with a linear internal buoyancy flux gain is a constant velocity lazy plume with reduced entrainment and radial growth rate. For highly lazy source conditions we derive first-order approximate solutions which indicate a region of zero entrainment near the source. These phenomena have previously been observed, however, it has often been assumed that reduced entrainment implies a reduced (α). We demonstrate that a constant (α) formulation is able to capture the behaviour of these reduced entrainment flows. Morton, B. R., Taylor, G. I. & Turner, J. S. (1956), Turbulent gravitational convection from maintained and instantaneous sources.', Proc. Roy. Soc. 234, 1-23.

  4. New advanced shotcrete admixtures: Internal curing

    SciTech Connect

    Melbye, T.A.

    1995-12-31

    Tunnels and other underground construction projects have one of the worst curing conditions due to the ventilation that blows continuously dry (cold or hot) air into the tunnel. It can be compared with concrete exposed to a windy area. One would think that tunnels have ideal curing conditions with high humidity (water leakage), no wind and no sun exposure. However, this is not the case. MBT has developed a new system for more efficient and secure curing of wet shotcrete, repair mortars as well as concrete. Internal curing means that a special admixture is added to the concrete/mortar during batching as a normal admixture. This admixture produces an internal barrier in the shotcrete/concrete which secures safer hydration and better chemical resistance than the application of conventional curing agents. The benefits resulting from the new technology are impressive: The time consuming application and, in the case of various shotcrete layers, removal of curing agents are no longer necessary; curing is guaranteed from the very beginning of hydration; and there is no negative influence on bonding between layers. As a consequence of th is optimum curing effect, all other shotcrete characteristics are improved: density, final strengths, freeze/thaw and chemical resistances, watertightness, less cracking and shrinkage. In addition, MEYCO TCC 735 also improves pumpability and workability of shotcrete, even with low-grade aggregates. It particularly improves the pumpability of steel fiber reinforced shotcrete mixes. In combination with the MEYCO TCC system it contrives to even increase the beneficial effects of the slump killing system by further improving fiber orientation, reducing fiber rebound and thus raising toughness values.

  5. Topological Signatures for Population Admixture

    USDA-ARS?s Scientific Manuscript database

    Topological Signatures for Population AdmixtureDeniz Yorukoglu1, Filippo Utro1, David Kuhn2, Saugata Basu3 and Laxmi Parida1* Abstract Background: As populations with multi-linear transmission (i.e., mixing of genetic material from two parents, say) evolve over generations, the genetic transmission...

  6. Mesler entrainment in alcohols

    NASA Astrophysics Data System (ADS)

    Saylor, J. R.; Sundberg, R. K.

    2012-11-01

    When a drop impacts a flat surface of the same liquid at an intermediate velocity, the impact can result in the formation of a very large number of very small bubbles. At lower velocities, drops bounce or float, and at larger velocities a single bubble forms, or there is a splash. The formation of large numbers of small bubbles during intermediate velocity impacts is termed Mesler entrainment and its controlling mechanism is poorly understood. Existing research has shown that Mesler entrainment is highly irreproducible when water is the working fluid, and very reproducible when silicone oil is the working fluid. Whether this is because water is problematic, or silicone oil is uniquely well-suited, is unclear. To answer this question, experiments were conducted using three different alcohols. The results of these experiments were very reproducible for all alcohols tested, suggesting that there is something unique about water which accounts for its lack of reproducibility. The data from these experiments were also used to develop a dimensionless group that quantifies the conditions under which Mesler entrainment occurs. This dimensionless group is used to provide insight into the mechanism of this unique method of bubble formation.

  7. Estimating bulk entrainment with aggregated and unaggregated convection

    NASA Astrophysics Data System (ADS)

    Becker, Tobias; Stevens, Bjorn; Hohenegger, Cathy; Bretherton, Chris

    2017-04-01

    Entrainment alters both the updraft mass flux and the updraft composition, especially its buoyancy. This study investigates how entrainment depends on the degree of convective aggregation in convection-permitting simulations. This is investigated with the ICON-LEM model with 1 km resolution, using a radiative-convective equilibrium framework that mimics conditions over the tropical ocean in a 600x600 km2 cubic domain with doubly-periodic boundary conditions. Bulk entrainment is quantified with a radioactive tracer, which is injected at the surface and decays in the atmosphere, with an e-folding time scale of 4 days. Vertically-integrated bulk entrainment estimates show that the entrainment rate is independent of the degree of aggregation, though entrainment rate varies more with height in aggregated conditions. Additionally, the entrainment rate is mostly independent of the updraft location within the aggregated cluster of convection, but entrainment does depend on the number of surrounding updraft grid points. However, the efficiency of entrainment strongly depends on the degree of aggregation. In aggregated conditions, the mean moist static energy in the nearby environment of updraft grid points is closer to the updraft moist static energy than in unaggregated conditions. Thus, when aggregating, the entrainment efficiency decreases by one third, considering all model levels between 850 hPa and 600 hPa. So aggregation does not affect how much mass is exchanged through entrainment, but it affects the constitution of the entrained air, thereby changing how efficient entrainment is in decreasing the updraft buoyancy. Although the impact of entrainment on updraft mass flux is the same in aggregated and unaggregated conditions, updraft mass flux is twice as large in unaggregated conditions as in aggregated conditions because cloud base mass flux is higher. The reason is that higher subsidence velocities are necessary for balancing the radiative cooling because the

  8. Ancient Admixture in Human History

    PubMed Central

    Patterson, Nick; Moorjani, Priya; Luo, Yontao; Mallick, Swapan; Rohland, Nadin; Zhan, Yiping; Genschoreck, Teri; Webster, Teresa; Reich, David

    2012-01-01

    Population mixture is an important process in biology. We present a suite of methods for learning about population mixtures, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture. We also describe the development of a new single nucleotide polymorphism (SNP) array consisting of 629,433 sites with clearly documented ascertainment that was specifically designed for population genetic analyses and that we genotyped in 934 individuals from 53 diverse populations. To illustrate the methods, we give a number of examples that provide new insights about the history of human admixture. The most striking finding is a clear signal of admixture into northern Europe, with one ancestral population related to present-day Basques and Sardinians and the other related to present-day populations of northeast Asia and the Americas. This likely reflects a history of admixture between Neolithic migrants and the indigenous Mesolithic population of Europe, consistent with recent analyses of ancient bones from Sweden and the sequencing of the genome of the Tyrolean “Iceman.” PMID:22960212

  9. The macroscopic entrainment processes of simulated cumulus ensemble. Part I: Entrainment sources

    SciTech Connect

    Lin, Chichung; Arakawa, A.

    1997-04-15

    Parameterization of cumulus convection requires a model that describes the statistical properties of a cumulus ensemble under given large-scale conditions. Such a model is called a cloud model for cumulus parameterization (CMCP). It would be best if the development of a CMCP were guided by synchronous observations covering a population of clouds. Unfortunately, observations for cumulus clouds are usually confined to individual clouds, leaving many uncertainties in designing a CMCP. In an attempt to improve the formulation of entrainment effects in a CMCP, the data simulated by a two-dimensional cloud-resolving model are used to investigate sources of entrainment into cumulus clouds. The authors first plot the Paluch diagram using the data from a nonprecipitating experiment. It is found that typical patterns on the Paluch diagram obtained by observational studies can be reproduced using the simulated data and can be interpreted in ways other than two-point mixing. The authors further examine entrainment sources through extensive trajectory analysis using the data from a precipitating experiment. They find that cloud air parcels at one level usually originate from locations of various heights, indicating a continuous series of entrainment events occurring throughout the cloud depth. However, the authors do not find a cloud air parcel decending more than several hundred meters. Penetrative downdrafts produced by mixing between cloud air and entrained air are not observed in the cases simulated. It seems that, as far as tropical deep convection is concerned, ignoring the contribution from descendent cloud air in a CMCP is an acceptable simplification. 52 refs., 14 figs.

  10. Premixed intravenous admixtures: a positive development for hospital pharmacy.

    PubMed

    Lee, H E

    1983-06-01

    The development of premixed intravenous admixtures is reviewed in a historical context, and its effects on hospital pharmacy practice are discussed. As pharmaceutical manufacturers introduce more i.v. medications in ready-to-use containers, the same complaints that were voiced by pharmacists about unit dose packaging and ready-to-dispense tablets and capsules are being aired. But premixed i.v. admixtures are a logical extension of the basic unit dose principle of providing a readily identifiable and ready-to-administer dose. The time and cost savings these products offer are needed in hospital pharmacies. Some of the disadvantages of these products--including storage and freezer space and multiplicity of administration systems--are overcome by proper planning and education of personnel. If fewer personnel are now needed to prepare i.v. admixtures, then those personnel should be used to improve patient care in other ways. The use of premixed i.v. admixtures is a positive technological advance in drug packaging. Its advantages outweight its disadvantages, and it will soon be become the universally accepted form of i.v. drug packaging.

  11. The macroscopic entrainment processes of simulated cumulus ensemble. Part II: Testing the entraining-plume model

    SciTech Connect

    Lin, Chichung; Arakawa, Akio

    1997-04-15

    According to Part I of this paper, is seems that ignoring the contribution from descendent cloud air in a cloud model for cumulus parameterization (CMCP), such as the spectral cumulus ensemble model in the Arakawa-Schubert parameterization, is an acceptable simplification for tropical deep convection. Since each subensemble in the spectral cumulus ensemble model is formally analogous to an entraining plume, the latter is examined using the simulated data from a cloud-resolving model (CRM). The authors first follow the analysis procedure of Warner. With the data from a nonprecipitating experiment, the authors show that the entraining-plume model cannot simultaneously predict the mean liquid water profile and cloud top height of the clouds simulated by the CRM. However, the mean properties of active elements of clouds, which are characterized by strong updrafts, can be described by an entraining plume of similar top height. With data from a precipitating experiment, the authors examine the spectral cumulus ensemble model using the Paluch diagram. It is found that the spectral cumulus ensemble model appears adequate if different types of clouds in the spectrum are interpreted as subcloud elements with different entrainment characteristics. The resolved internal structure of clouds can thus be viewed as a manifestation of a cloud spectrum. To further investigate whether the fractional rate of entrainment is an appropriate parameter for characterizing cloud types in the spectral cumulus ensemble model, the authors stratify the simulated saturated updrafts (subcloud elements) into different types according to their eventual heights and calculate the cloud mass flux and mean moist static energy for each type. Entrainment characteristics are then inferred through the cloud mass flux and in-cloud moist static energy. It is found that different types of subcloud elements have distinguishable thermodynamic properties and entrainment characteristics. 16 refs., 8 figs.

  12. High-Resolution Entrainment in Stratocumulus During the POST Campaign

    NASA Astrophysics Data System (ADS)

    Gerber, H. E.

    2012-12-01

    In July and August of 2008 an NSF-supported field campaign called POST (Physics of Stratocumulus Top) was conducted off the California coast using the fully-instrumented Twin Otter aircraft from the Naval Post Graduate School. POST provided the first opportunity to closely co-locate on an aircraft high-rate and time synchronized microphysics (PVM; LWC and effective radius) and thermodynamics (UFT; Ultra-Fast Temperature) probes and a gust probe to produce measurements of entrainment fluxes and features over entrainment scales thought to be important in warm stratocumulus (Sc). This combination of probes permitted investigating the properties of individual entrained parcels Seventeen flights were conducted during POST in a quasi-Lagrangian fashion in largely unbroken stratocumulus. The horizontal fight path was adjusted to follow the mean air velocity in the Sc. The vertical flight path concentrated on flying between 100-m above and below the cloud-top interface; and some additional profiles were flown to various higher and lower levels where flux runs were made. This presentation describes the analysis of this unique and excellent data set including the following: The data permitted testing Lilly's classical theory for the entrainment velocity where its application requires strong jumps of temperature and moisture across the inversion located above cloud top, a linear flux of the entrained scalar below cloud top, and entrained parcels that descend. All flights showed Sc with wind shear and mixing at cloud top with some strong enough to dissipate the Sc. The relationship between shear and entrainment velocity is described. The pdf of the horizontal size of entrainment parcels vs entrainment flux is established for all flights to help in choosing grid-sizes for modeling. High -resolution in-cloud temperature and LWC measurements in entrained parcels reveal the relative importance of radiative cooling vs cooling by liquid water evaporation in causing buoyancy reversal

  13. Entrainment Characteristics for variable-angle plunging liquid jets

    NASA Astrophysics Data System (ADS)

    Deshpande, Suraj; Trujillo, Mario

    2013-11-01

    Simulations based on an algebraic VoF method are used to study the entrainment characteristics of a water jet plunging into a quiescent pool at angles ranging from 10 to 90 deg. with pool. Our previous study of shallow plunging jets (Deshpande et al. 2012) revealed a discernible frequency in the formation of large air cavities. This contrasts the well-documented chaotic entrainment at steeper inclinations, suggesting a different entrainment mechanism exists for shallow angles. Quantitatively, it is found that larger cavities and greater volume of entrained air occur at shallower angles (10, 12 deg.). A precursor to the formation of these large cavities is the presence of a stagnation region in the zone of impingement. Using a local mass and momentum balance, we show that this stagnation region deflects the incoming jet at wide angles producing large air cavities. Entrainment in shallow jets is similar to the initial impact of the jet with a pool, but it occurs periodically. The recurrence is a consequence of jet disruption by traveling waves on the pool. Qualitative analysis, supported with simulations, demonstrates linear scaling of entrainment period with Froude number.

  14. A Quantitative Investigation of Entrainment and Detrainment in Numerically Simulated Convective Clouds. Pt. 2; Simulations of Cumulonimbus Clouds

    NASA Technical Reports Server (NTRS)

    Cohen, Charles

    1998-01-01

    Deep cumulonimbus clouds are simulated using a model that makes accurate diagnoses of entrainment and detrainment rates and of the properties of entrained and detrained air. Clouds generated by a variety of initial thermodynamic soundings are compared. In the simulations, updraft entrainment rates are large near and above cloud base, through the entire depth of the conditionally unstable layer. Stronger updrafts in a more unstable environment are better able to entrain relatively undisturbed environmental air, while weaker updrafts can entrain only air that has been modified by the clouds. When the maximum buoyancy is large, the updraft includes parcels with a wide range of buoyancies, while weaker clouds are more horizontally uniform. Strong downdrafts originate from levels at which updrafts detrain, and their mass flux depends on the mass flux of the updraft. The magnitude of mixing between cloud and environment, not the entrainment rate, varies inversely with the cloud radius. How much of the mixed air is entrained depends on the buoyancy.

  15. Entraining synthetic genetic oscillators

    NASA Astrophysics Data System (ADS)

    Wagemakers, Alexandre; Buldú, Javier M.; Sanjuán, Miguel A. F.; de Luis, Oscar; Izquierdo, Adriana; Coloma, Antonio

    2009-09-01

    We propose a new approach for synchronizing a population of synthetic genetic oscillators, which consists in the entrainment of a colony of repressilators by external modulation. We present a model where the repressilator dynamics is affected by periodic changes in temperature. We introduce an additional plasmid in the bacteria in order to correlate the temperature variations with the enhancement of the transcription rate of a certain gene. This can be done by introducing a promoter that is related to the heat shock response. This way, the expression of that gene results in a protein that enhances the overall oscillations. Numerical results show coherent oscillations of the population for a certain range of the external frequency, which is in turn related to the natural oscillation frequency of the modified repressilator. Finally we study the transient times related with the loss of synchronization and we discuss possible applications in biotechnology of large-scale production coupled to synchronization events induced by heat shock.

  16. Power plant intake entrainment analysis

    SciTech Connect

    Edinger, J.E.; Kolluru, V.S.

    2000-04-01

    Power plant condenser cooling water intake entrainment of fish eggs and larvae is becoming an issue in evaluating environmental impacts around the plants. Methods are required to evaluate intake entrainment on different types of water bodies. Presented in this paper is a derivation of the basic relationships for evaluating entrainment from the standing crop of fish eggs and larvae for different regions of a water body, and evaluating the rate of entrainment from the standing crop. These relationships are coupled with a 3D hydrodynamic and transport model that provides the currents and flows required to complete the entrainment evaluation. Case examples are presented for a simple river system, and for the more complex Delaware River Estuary with multiple intakes. Example evaluations are made for individual intakes, and for the cumulative impacts of multiple intakes.

  17. Lidar measurements of the atmospheric entrainment zone and the potential temperature jump across the top of the mixed layer

    NASA Technical Reports Server (NTRS)

    Boers, R.; Eloranta, E. W.

    1986-01-01

    Lidar data of the atmospheric entrainment zone from six days of clear air convection obtained in central Illinois during July 1979 are presented. A new method to measure the potential temperature jump across the entrainment zone based on only one temperature sounding and continuous lidar measurements of the mixed layer height is developed. An almost linear dependence is found between the normalized entrainment rate and the normalized thickness of the entrainment zone.

  18. The influence of Kr, CO2, and iso-C4H8 admixtures on the time of the formation of a stable flame front in mixtures of natural gas and isobutylene with oxygen and hydrogen with air under initiation with a spark discharge

    NASA Astrophysics Data System (ADS)

    Rubtsov, N. M.; Seplyarskii, B. S.; Chernysh, V. I.; Tsvetkov, G. I.

    2010-05-01

    High-speed color filming was used to study laminar spherical flame propagation at the initial stage in preliminarily mixed stoichiometric mixtures of natural gas and isobutylene with oxygen containing krypton and carbon dioxide and in hydrogen-air mixtures at atmospheric pressure in a bomb with a constant volume. Under experimental conditions ( T 0 = 298 K, p 0 = 100 torr, spark discharge energy E 0 = 0.91 J), the dilution of mixtures with Kr and CO2 increased the time of formation of a stable flame front by more than 10 times. The introduction of a small chemically active admixture (1.2% isobutylene) into a stoichiometric mixture of hydrogen and air sharply increased the time of formation of a stable flame front, which was evidence of an important role played by the chemical mechanism of the reaction in the formation of the combustion field.

  19. Estimation of convective entrainment properties from a cloud-resolving model simulation during TWP-ICE

    NASA Astrophysics Data System (ADS)

    Zhang, Guang J.; Wu, Xiaoqing; Zeng, Xiping; Mitovski, Toni

    2016-10-01

    The fractional entrainment rate in convective clouds is an important parameter in current convective parameterization schemes of climate models. In this paper, it is estimated using a 1-km-resolution cloud-resolving model (CRM) simulation of convective clouds from TWP-ICE (the Tropical Warm Pool-International Cloud Experiment). The clouds are divided into different types, characterized by cloud-top heights. The entrainment rates and moist static energy that is entrained or detrained are determined by analyzing the budget of moist static energy for each cloud type. Results show that the entrained air is a mixture of approximately equal amount of cloud air and environmental air, and the detrained air is a mixture of ~80 % of cloud air and 20 % of the air with saturation moist static energy at the environmental temperature. After taking into account the difference in moist static energy between the entrained air and the mean environment, the estimated fractional entrainment rate is much larger than those used in current convective parameterization schemes. High-resolution (100 m) large-eddy simulation of TWP-ICE convection was also analyzed to support the CRM results. It is shown that the characteristics of entrainment rates estimated using both the high-resolution data and CRM-resolution coarse-grained data are similar. For each cloud category, the entrainment rate is high near cloud base and top, but low in the middle of clouds. The entrainment rates are best fitted to the inverse of in-cloud vertical velocity by a second order polynomial.

  20. Wind profiler mixing depth and entrainment measurements with chemical applications

    SciTech Connect

    Angevine, W.M.; Trainer, M.; Parrish, D.D.; Buhr, M.P.; Fehsenfeld, F.C.; Kok, G.L.

    1994-12-31

    Wind profiling radars operating at 915 MHz have been present at a number of regional air quality studies. The profilers can provide a continuous, accurate record of the depth of the convective mixed layer with good time resolution. Profilers also provide information about entrainment at the boundary layer top. Mixing depth data from several days of the Rural Oxidants in the Southern Environment II (ROSE II) study in Alabama in June, 1992 are presented. For several cases, chemical measurements from aircraft and ground-based instruments are shown to correspond to mixing depth and entrainment zone behavior observed by the profiler.

  1. Compounding times and contamination rates associated with the preparation of intravenous admixtures in three types of plastic containers.

    PubMed

    Allinson, R R; Stach, P E; Sherrin, T P; Latiolais, C J

    1979-04-01

    The compounding times and contamination rates associated with the preparation of admixtures in three different plastic i.v. containers of dextrose 5% in water were compared. The time required for a technician to prepare, in a laminar air flow hood by the needle and syringe technique, 120 admixtures in each of three different plastic i.v. containers was measured and recorded by two investigators. The 360 admixtures were tested within one hour of preparation for sterility using an enriched brain heart infusion broth. The total time required to compound the i.v. admixtures varied significantly with container design (p less than 0.01), preparation being fastest with the Accumed container, followed by the LifeCare then the Viaflex containers. The major contributing factors to increased compounding time were (1) removal of outer wrap, (2) swabbing of LifeCare and Viaflex medication ports with isopropyl alcohol pads and (3) freeing of the hangar flap from the Viaflex container. Sterility tests revealed no detectable contamination of any of the admixtures. Container design of plastic i.v. containers did influence the preparation time for admixtures but did not influence admixture sterility.

  2. Effect of particle entrainment on the runout of pyroclastic density currents

    NASA Astrophysics Data System (ADS)

    Fauria, Kristen E.; Manga, Michael; Chamberlain, Michael

    2016-09-01

    Pyroclastic density currents (PDCs) can erode soil and bedrock, yet we currently lack a mechanistic understanding of particle entrainment that can be incorporated into models and used to understand how PDC bulking affects runout. Here we quantify how particle splash, the ejection of particles due to impact by a projectile, entrains particles into dilute PDCs. We use scaled laboratory experiments to measure the mass of sand ejected by impacts of pumice, wood, and nylon spheres. We then derive an expression for particle splash that we validate with our experimental results as well as results from seven other studies. We find that the number of ejected particles scales with the kinetic energy of the impactor and the depth of the crater generated by the impactor. Last, we use a one-dimensional model of a dilute, compressible density current—where runout distance is controlled by air entrainment and particle exchange with the substrate—to examine how particle entrainment by splash affects PDC density and runout. Splash-driven particle entrainment can increase the runout distance of dilute PDCs by an order of magnitude. Furthermore, the temperature of entrained particles greatly affects runout and PDCs that entrain ambient temperature particles runout farther than those that entrain hot particles. Particle entrainment by splash therefore not only increases the runout of dilute PDCs but demonstrates that the temperature and composition of the lower boundary have consequences for PDC density, temperature, runout, hazards and depositional record.

  3. Distinguishing Recent Admixture from Ancestral Population Structure

    PubMed Central

    Slatkin, Montgomery

    2017-01-01

    We develop and test two methods for distinguishing between recent admixture and ancestral population structure as explanations for greater similarity of one of two populations to an outgroup population. This problem arose when Neanderthals were found to be slightly more similar to nonAfrican than to African populations. The excess similarity is consistent with both recent admixture from Neanderthals into the ancestors of nonAfricans and subdivision in the ancestral population. Although later studies showed that there had been recent admixture, distinguishing between these two classes of models will be important in other situations, particularly when high-coverage genomes cannot be obtained for all populations. One of our two methods is based on the properties of the doubly conditioned frequency spectrum combined with the unconditional frequency spectrum. This method does not require a linkage map and can be used when there is relatively low coverage. The second method uses the extent of linkage disequilibrium among closely linked markers. PMID:28186554

  4. Estimating ethnic admixture from pedigree data.

    PubMed

    Sinsheimer, Janet S; Plaisier, Christopher L; Huertas-Vazquez, Adriana; Aguilar-Salinas, Carlos; Tusie-Luna, Teresa; Pajukanta, Päivi; Lange, Kenneth

    2008-03-01

    This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The large-sample standard errors of the founders' proportions can be similarly transformed into standard errors for the admixture proportions of the descendants. These standard errors are smaller than the corresponding standard errors when each individual is treated independently. Both hard and soft information on a founder's ancestry can be accommodated in this scheme, which has been implemented in the genetic software package Mendel. The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry.

  5. Laminar Plunging Jets - Interfacial Rupture and Inception of Entrainment

    NASA Astrophysics Data System (ADS)

    Kishore, Aravind

    Interfacial rupture and entrainment are commonly observed, e.g., air bubbles within a container being filled with water from a faucet. The example involves a liquid jet (density, rho, and viscosity, η) plunging into a receiving pool of liquid. Below a critical liquid-jet velocity, the interface develops a cusp-like shape within the receiving pool. The cusp becomes sharper with increasing liquid-jet velocity, and at a critical velocity ( Vc), the interface between the liquid and the surrounding fluid (density, rho0, and viscosity, η0) ruptures. Interfacial tension (sigma) can no longer preserve the integrity of the interface between the two immiscible fluids, and the plunging jet drags/entrains surrounding fluid into the receiving pool. Subsequently, the entrained fluid breaks up into bubbles within the receiving pool. The focus of this dissertation is the numerical prediction of the critical entrainment inception velocities for laminar plunging jets using the Volume-Of-Fluid (VOF) method, a Computational Fluid Dynamics (CFD) method to simulate multi-fluid flows. Canonical to bottle-filling operations in the industry is the plunging-jet configuration -- the liquid jet issues from a nozzle and plunges into a container filled with liquid. Simulations of this configuration require capturing flow phenomena over a large range of length scales (4 orders of magnitude). Results show severe under-prediction of critical entrainment velocities when the maximum resolution is insufficient to capture the sharpening, and eventual rupture, of the interfacial cusp. Higher resolutions resulted in computational meshes with prohibitively large number of cells, and a drastic reduction in time-step values. Experimental results in the literature suggest at least a 100-fold increase in the smallest length scale when the entrained fluid is a liquid instead of air. This narrows the range of length scales in the problem. We exploit the experimental correlation between critical capillary

  6. Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors.

    PubMed

    Martinez-Marignac, Veronica L; Valladares, Adan; Cameron, Emily; Chan, Andrea; Perera, Arjuna; Globus-Goldberg, Rachel; Wacher, Niels; Kumate, Jesús; McKeigue, Paul; O'Donnell, David; Shriver, Mark D; Cruz, Miguel; Parra, Esteban J

    2007-02-01

    Admixture mapping is a recently developed method for identifying genetic risk factors involved in complex traits or diseases showing prevalence differences between major continental groups. Type 2 diabetes (T2D) is at least twice as prevalent in Native American populations as in populations of European ancestry, so admixture mapping is well suited to study the genetic basis of this complex disease. We have characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275 controls from Mexico City and we discuss the implications of the results for admixture mapping studies. Admixture proportions were estimated using 69 autosomal ancestry-informative markers (AIMs). Maternal and paternal contributions were estimated from geographically informative mtDNA and Y-specific polymorphisms. The average proportions of Native American, European and, West African admixture were estimated as 65, 30, and 5%, respectively. The contributions of Native American ancestors to maternal and paternal lineages were estimated as 90 and 40%, respectively. In a logistic model with higher educational status as dependent variable, the odds ratio for higher educational status associated with an increase from 0 to 1 in European admixture proportions was 9.4 (95%, credible interval 3.8-22.6). This association of socioeconomic status with individual admixture proportion shows that genetic stratification in this population is paralleled, and possibly maintained, by socioeconomic stratification. The effective number of generations back to unadmixed ancestors was 6.7 (95% CI 5.7-8.0), from which we can estimate that genome-wide admixture mapping will require typing about 1,400 evenly distributed AIMs to localize genes underlying disease risk between populations of European and Native American ancestry. Sample sizes of about 2,000 cases will be required to detect any locus that contributes an ancestry risk ratio of at least 1.5.

  7. Investigation of the Entrainment Phenomenon Using a Scaling Approach

    NASA Astrophysics Data System (ADS)

    Kishore, Aravind; Ghia, Urmila

    2014-11-01

    Air entrainment is a commonly observed phenomenon; we see it when filling a glass with water from a faucet, in the frothing of the ocean surface, in white water rapids, etc. The focus of our work is the numerical simulation of the entrainment phenomenon associated with laminar plunging jets. With increasing jet velocity, the interfacial cusp formed between the jet and the liquid pool becomes sharper. At a critical jet velocity, entrainment inception occurs, i.e., the interfacial cusp breaks, the interface ruptures, and air is pulled into the liquid pool. We conduct two-fluid simulations using the Volume-Of-Fluid (VOF) methodology. The large range of length scales in the flow presents a major computational challenge. We postulate an approach based on scaling of the underlying physics and this helps alleviate the constraints that the physics poses on the numerical method. The approach is validated using a simple flow configuration - a cylinder rotating at an interface between two fluids. Our simulations capture the sharpening of the interfacial cusp, and the sudden rupture of the interface. The predicted critical entrainment velocities are within 1% of experimental data, thereby providing confidence in the approach. This work was supported by the UC Simulation Center at the University of Cincinnati.

  8. Cold Weather Admixture Systems Demonstration at Fort Wainwright, Alaska

    DTIC Science & Technology

    2010-08-01

    oz/cwt. Rheocrete® CNI is a corrosion inhibiting admixture (BASF 2007b). While corrosion inhibitors are used to protect embedded steel members...Washington, DC 20314-1000 ERDC/CRREL TR-10-6 ii Abstract: Cold Weather Admixture Systems (CWAS) is a new approach to cold weather concreting that...incorporates suites of commercially avail- able chemical admixtures in concrete mixes. When used in combination, these admixtures depress the freezing

  9. The Stochastic Parcel Model: A deterministic parameterization of stochastically entraining convection

    NASA Astrophysics Data System (ADS)

    Romps, David M.

    2016-03-01

    Convective entrainment is a process that is poorly represented in existing convective parameterizations. By many estimates, convective entrainment is the leading source of error in global climate models. As a potential remedy, an Eulerian implementation of the Stochastic Parcel Model (SPM) is presented here as a convective parameterization that treats entrainment in a physically realistic and computationally efficient way. Drawing on evidence that convecting clouds comprise air parcels subject to Poisson-process entrainment events, the SPM calculates the deterministic limit of an infinite number of such parcels. For computational efficiency, the SPM groups parcels at each height by their purity, which is a measure of their total entrainment up to that height. This reduces the calculation of convective fluxes to a sequence of matrix multiplications. The SPM is implemented in a single-column model and compared with a large-eddy simulation of deep convection.

  10. Entrainment by the jet in HH 47

    NASA Technical Reports Server (NTRS)

    Raymond, John C.; Morse, Jon A.; Hartigan, P.; Curiel, S.; Heathcote, Steve

    1994-01-01

    Fabry-Perot images of the HH 47 optical jet show that the velocity decreases from the center toward the edges which is interpreted as evidence for entrainment. Those images can be used to investigate the rate of entrainment required to account for the observed luminosity. Entrainment along the jet can account for only small fractions of the jet mass and the molecular outflow seen in CO. We compare the density, excitation, and velocity structure of the jet with the predictions of viscous entrainment models and models of entrainment by expulsion of jet material by internal shocks, and find that either type of model can explain the general features.

  11. Ozone Laminae and Their Entrainment Into a Valley Boundary Layer, as Observed From a Mountaintop Monitoring Station, Ozonesondes, and Aircraft Over California's San Joaquin Valley

    NASA Astrophysics Data System (ADS)

    Faloona, I. C.; Conley, S. A.; Caputi, D.; Trousdell, J.; Chiao, S.; Eiserloh, A. J., Jr.; Clark, J.; Iraci, L. T.; Yates, E. L.; Marrero, J. E.; Ryoo, J. M.; McNamara, M. E.

    2016-12-01

    The San Joaquin Valley of California is wide ( 75 km) and long ( 400 km), and is situated under strong atmospheric subsidence due, in part, to the proximity of the midlatitude anticyclone of the Pacific High. The capping effect of this subsidence is especially prominent during the warm season when ground level ozone is a serious air quality concern across the region. While relatively clean marine boundary layer air is primarily funneled into the valley below the strong subsidence inversion at significant gaps in the upwind Coast Range mountains, airflow aloft also spills over these barriers and mixes into the valley from above. Because this transmountain flow occurs under the influence of synoptic subsidence it tends to present discrete, laminar sheets of differing air composition above the valley boundary layer. Meanwhile, although the boundary layers tend to remain shallow due to the prevailing subsidence, orographic and anabatic venting of valley boundary layer air around the basin whips up a complex admixture of regional air masses into a "buffer layer" just above the boundary layer (zi) and below the lower free troposphere. We present scalar data of widely varying lifetimes including ozone, methane, NOx, and thermodynamic observations from upwind and within the San Joaquin Valley to better explain this layering and its subsequent erosion into the valley boundary layer via entrainment. Data collected at a mountaintop monitoring station on Chews Ridge in the Coast Range, by coastal ozonesondes, and aircraft are analyzed to document the dynamic layering processes around the complex terrain surrounding the valley. Particular emphasis will be made on observational methods whereby distal ozone can be distinguished from the regional ozone to better understand the influence of exogenous sources on air quality in the valley.

  12. Entrainment in electrohydrodynamic heat pipes

    NASA Technical Reports Server (NTRS)

    Jones, T. B.; Perry, M. P.

    1972-01-01

    A theoretical analysis for predicting the onset of the Kelvin-Helmholtz instability is reported. The model for the analysis is described, and the derived stability criterion are given. It is concluded that surface tension plays a role in the entrainment limit of electro hydrodynamic heat pipes. The surface of the liquid in an EHD flow structure is open, with no restriction placed on the wavenumbers of perturbations.

  13. Timescales of Massive Human Entrainment

    PubMed Central

    Fusaroli, Riccardo; Perlman, Marcus; Mislove, Alan; Paxton, Alexandra; Matlock, Teenie; Dale, Rick

    2015-01-01

    The past two decades have seen an upsurge of interest in the collective behaviors of complex systems composed of many agents entrained to each other and to external events. In this paper, we extend the concept of entrainment to the dynamics of human collective attention. We conducted a detailed investigation of the unfolding of human entrainment—as expressed by the content and patterns of hundreds of thousands of messages on Twitter—during the 2012 US presidential debates. By time-locking these data sources, we quantify the impact of the unfolding debate on human attention at three time scales. We show that collective social behavior covaries second-by-second to the interactional dynamics of the debates: A candidate speaking induces rapid increases in mentions of his name on social media and decreases in mentions of the other candidate. Moreover, interruptions by an interlocutor increase the attention received. We also highlight a distinct time scale for the impact of salient content during the debates: Across well-known remarks in each debate, mentions in social media start within 5–10 seconds after it occurs; peak at approximately one minute; and slowly decay in a consistent fashion across well-known events during the debates. Finally, we show that public attention after an initial burst slowly decays through the course of the debates. Thus we demonstrate that large-scale human entrainment may hold across a number of distinct scales, in an exquisitely time-locked fashion. The methods and results pave the way for careful study of the dynamics and mechanisms of large-scale human entrainment. PMID:25880357

  14. Localizing ventricular tachycardia through entrainment.

    PubMed

    Kuo, C T; Luqman, N; Lin, K H; Chiang, C W

    2000-12-01

    Area(s) of slow conduction are thought to be present within the reentry circuit of most clinically important ventricular tachycardia (VT). To prevent recurrence after ablation of VT late after myocardial infarction, it is desirable to localize and destroy area(s) of slow conduction "critical link" within the reentry circuit. Conventionally, they may be identified by endocardial catheter mapping, continuous electrical activity, mid-diastolic potentials, earliest endocardial activation, pace-mapping etc. However, none of these methods are very specific. Entrainment method may be used to localize the slow conduction zone of reentrant VT. Concealed entrainment is consistent with pacing at a site in the reentry circuit but may also occur at some "bystander" sites that are close to the reentry circuit but are not participating in the circuit itself. During pacing at the slow conduction area of the reentry circuit, the stimulus to QRS (S-QRS) interval should equal the electrogram to QRS (EG-QRS) interval during VT. Similarly the post-pacing interval (PPI) approximates the tachycardia cycle length. During pacing at bystander sites, the S-QRS interval may be greater, less than or equal to the EG-QRS interval, depending on the conduction time from the bystander site to the circuit. The PPI, however, always exceed the tachycardia cycle length. In conjunction with concealed entrainment, the use of diastolic potential, double potentials and continuous electrical activity enhances the prediction of radiofrequency termination of post-infarction VT.

  15. Pulsar rotation with superfluid entrainment

    NASA Astrophysics Data System (ADS)

    Antonelli, Marco; Pizzochero, Pierre M.

    2017-06-01

    Large pulsar glitches (like the ones detected in the Vela) are though to be a consequence of the superfluid component present in the interior of mature neutron stars: this component can rotate differentially with respect to the normal part of the star, storing the angular momentum needed to produce the observed sudden decrease of the pulsar rotational period. However strong entrainment (a non-dissipative effect that couples the superfluid component with the non-superfluid component inside the star) challenges this picture. Here we study the impact of entrainment on the angular momentum that can be exchanged between the normal component and the superfluid during a glitch by means of a consistent global model. This allows to estimate the maximum angular momentum reservoir stored into the superfluid component of the star: the essential ingredient are newly calculated mesoscopic pinning forces that block the superfluid vorticity in the crust of the neutron star. This method can also provide a quantitative test for global models of rotating neutron stars, as well as for microphysical inputs present in literature (like entrainment parameters and pinning forces).

  16. Scale dependence of entrainment-mixing mechanisms in cumulus clouds

    DOE PAGES

    Lu, Chunsong; Liu, Yangang; Niu, Shengjie; ...

    2014-12-17

    This work empirically examines the dependence of entrainment-mixing mechanisms on the averaging scale in cumulus clouds using in situ aircraft observations during the Routine Atmospheric Radiation Measurement Aerial Facility Clouds with Low Optical Water Depths Optical Radiative Observations (RACORO) field campaign. A new measure of homogeneous mixing degree is defined that can encompass all types of mixing mechanisms. Analysis of the dependence of the homogenous mixing degree on the averaging scale shows that, on average, the homogenous mixing degree decreases with increasing averaging scales, suggesting that apparent mixing mechanisms gradually approach from homogeneous mixing to extreme inhomogeneous mixing with increasingmore » scales. The scale dependence can be well quantified by an exponential function, providing first attempt at developing a scale-dependent parameterization for the entrainment-mixing mechanism. The influences of three factors on the scale dependence are further examined: droplet-free filament properties (size and fraction), microphysical properties (mean volume radius and liquid water content of cloud droplet size distributions adjacent to droplet-free filaments), and relative humidity of entrained dry air. It is found that the decreasing rate of homogeneous mixing degree with increasing averaging scales becomes larger with larger droplet-free filament size and fraction, larger mean volume radius and liquid water content, or higher relative humidity. The results underscore the necessity and possibility of considering averaging scale in representation of entrainment-mixing processes in atmospheric models.« less

  17. Scale dependence of entrainment-mixing mechanisms in cumulus clouds

    SciTech Connect

    Lu, Chunsong; Liu, Yangang; Niu, Shengjie; Endo, Satoshi

    2014-12-17

    This work empirically examines the dependence of entrainment-mixing mechanisms on the averaging scale in cumulus clouds using in situ aircraft observations during the Routine Atmospheric Radiation Measurement Aerial Facility Clouds with Low Optical Water Depths Optical Radiative Observations (RACORO) field campaign. A new measure of homogeneous mixing degree is defined that can encompass all types of mixing mechanisms. Analysis of the dependence of the homogenous mixing degree on the averaging scale shows that, on average, the homogenous mixing degree decreases with increasing averaging scales, suggesting that apparent mixing mechanisms gradually approach from homogeneous mixing to extreme inhomogeneous mixing with increasing scales. The scale dependence can be well quantified by an exponential function, providing first attempt at developing a scale-dependent parameterization for the entrainment-mixing mechanism. The influences of three factors on the scale dependence are further examined: droplet-free filament properties (size and fraction), microphysical properties (mean volume radius and liquid water content of cloud droplet size distributions adjacent to droplet-free filaments), and relative humidity of entrained dry air. It is found that the decreasing rate of homogeneous mixing degree with increasing averaging scales becomes larger with larger droplet-free filament size and fraction, larger mean volume radius and liquid water content, or higher relative humidity. The results underscore the necessity and possibility of considering averaging scale in representation of entrainment-mixing processes in atmospheric models.

  18. A genetic atlas of human admixture history

    PubMed Central

    Hellenthal, Garrett; Busby, George B.J.; Band, Gavin; Wilson, James F.; Capelli, Cristian

    2014-01-01

    Modern genetic data combined with appropriate statistical methods have the potential to contribute substantially to our understanding of human history. We have developed an approach that exploits the genomic structure of admixed populations to date and characterize historical mixture events at fine scales. We used this to produce an atlas of worldwide human admixture history, constructed using genetic data alone and encompassing over 100 events occurring over the past 4,000 years. We identify events whose dates and participants suggest they describe genetic impacts of the Mongol Empire, Arab slave trade, Bantu expansion, first millennium CE migrations in eastern Europe, and European colonialism, as well as unrecorded events, revealing admixture to be an almost universal force shaping human populations. PMID:24531965

  19. Heterogeneity in Genetic Admixture across Different Regions of Argentina

    PubMed Central

    Avena, Sergio; Via, Marc; Ziv, Elad; Pérez-Stable, Eliseo J.; Gignoux, Christopher R.; Dejean, Cristina; Huntsman, Scott; Torres-Mejía, Gabriela; Dutil, Julie; Matta, Jaime L.; Beckman, Kenneth; Burchard, Esteban González; Parolin, María Laura; Goicoechea, Alicia; Acreche, Noemí; Boquet, Mariel; Ríos Part, María Del Carmen; Fernández, Vanesa; Rey, Jorge; Stern, Mariana C.; Carnese, Raúl F.; Fejerman, Laura

    2012-01-01

    The population of Argentina is the result of the intermixing between several groups, including Indigenous American, European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individuals from different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers (AIMs) was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European (95%CI: 63–68%), 31% Indigenous American (28–33%) and 4% African (3–4%). We observed statistically significant differences in European ancestry across Argentine regions [Buenos Aires province (BA) 76%, 95%CI: 73–79%; Northeast (NEA) 54%, 95%CI: 49–58%; Northwest (NWA) 33%, 95%CI: 21–41%; South 54%, 95%CI: 49–59%; p<0.0001] as well as between the capital and immediate suburbs of Buenos Aires city compared to more distant suburbs [80% (95%CI: 75–86%) versus 68% (95%CI: 58–77%), p = 0.01]. European ancestry among individuals that declared all grandparents born in Europe was 91% (95%CI: 88–94%) compared to 54% (95%CI: 51–57%) among those with no European grandparents (p<0.001). Our results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population. PMID:22506044

  20. Entrainment by turbulent jets issuing from sharp-edged inlet round nozzles

    NASA Astrophysics Data System (ADS)

    Trabold, T. A.; Essen, E. B.; Obot, N. T.

    Experiments were carried out to determine entrainment rates by turbulent air jets generated with square-edged inlet round nozzles. A parametric study was made which included the effects of Reynolds number, nozzle length, partial confinement and geometry of the jet plenum chamber. Measurements were made for the region extending from the nozzle exit to 24 jet hole diameters downstream. There is a large difference in entrainment rate between jets generated with relatively short nozzles and those discharged through long tubes.

  1. Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE.

    PubMed

    Molineros, J E; Kim-Howard, X; Deshmukh, H; Jacob, C O; Harley, J B; Nath, S K

    2009-07-01

    Systemic Lupus Erythematosus (SLE) disproportionately affects minorities, such as Hispanic Americans (HA). Prevalence of SLE is 3-5 times higher in HA than in European-derived populations and have more active disease at the time of diagnosis, with more serious organ system involvement. HA is an admixed population, it is possible that there is an effect of admixture on the relative risk of the disease. This admixture can create substantial increase of linkage disequilibrium (LD) in both magnitude and range, which can provide a unique opportunity for admixture mapping. The main objectives of this study are to (a) estimate hidden population structure in HA individuals; (b) estimate individual ancestry proportions and its impact on SLE risk; (c) assess impact of admixture on ITGAM association, a recently identified SLE susceptibility gene; and (d) estimate power of admixture mapping in HA. Our dataset contained 1125 individuals, of whom 884 (657 SLE cases and 227 controls) were self-classified as HA. Using 107 unlinked ancestry informative markers (AIMs), we estimated hidden population structure and individual ancestry in HA. Out of 5671 possible pairwise LD, 54% were statistically significant, indicating recent population admixture. The best-fitted model for HA was a four-population model with average ancestry of European (48%), American-Indian (AI) (40%), African (8%) and a fourth population (4%) with unknown ancestry. We also identified significant higher risk associated with AI ancestry (odds ratio (OR)=4.84, P=0.0001, 95% CI (confidence interval)=2.14-10.95) on overall SLE. We showed that ITGAM is associated as a risk factor for SLE (OR=2.06, P=8.74 x 10(-5), 95% CI=1.44-2.97). This association is not affected by population substructure or admixture. We have shown that HA have great potential and are an appropriate population for admixture mapping. As expected, the case-only design is more powerful than case-control design, for any given admixture proportion or

  2. Using circadian entrainment to find cryptic clocks.

    PubMed

    Eelderink-Chen, Zheng; Olmedo, Maria; Bosman, Jasper; Merrow, Martha

    2015-01-01

    Three properties are most often attributed to the circadian clock: a ca. 24-h free-running rhythm, temperature compensation of the circadian rhythm, and its entrainment to zeitgeber cycles. Relatively few experiments, however, are performed under entrainment conditions. Rather, most chronobiology protocols concern constant conditions. We have turned this paradigm around and used entrainment to study the circadian clock in organisms where a free-running rhythm is weak or lacking. We describe two examples therein: Caenorhabditis elegans and Saccharomyces cerevisiae. By probing the system with zeitgeber cycles that have various structures and amplitudes, we can demonstrate the establishment of systematic entrained phase angles in these organisms. We conclude that entrainment can be utilized to discover hitherto unknown circadian clocks and we discuss the implications of using entrainment more broadly, even in model systems that show robust free-running rhythms.

  3. Crustal entrainment and pulsar glitches.

    PubMed

    Chamel, N

    2013-01-04

    Large pulsar frequency glitches are generally interpreted as sudden transfers of angular momentum between the neutron superfluid permeating the inner crust and the rest of the star. Despite the absence of viscous drag, the neutron superfluid is strongly coupled to the crust due to nondissipative entrainment effects. These effects are shown to severely limit the maximum amount of angular momentum that can possibly be transferred during glitches. In particular, it is found that the glitches observed in the Vela pulsar require an additional reservoir of angular momentum.

  4. A Genomewide Admixture Map for Latino Populations

    PubMed Central

    Price, Alkes L. ; Patterson, Nick ; Yu, Fuli ; Cox, David R. ; Waliszewska, Alicja ; McDonald, Gavin J. ; Tandon, Arti ; Schirmer, Christine ; Neubauer, Julie ; Bedoya, Gabriel ; Duque, Constanza ; Villegas, Alberto ; Bortolini, Maria Catira ; Salzano, Francisco M. ; Gallo, Carla ; Mazzotti, Guido ; Tello-Ruiz, Marcela ; Riba, Laura ; Aguilar-Salinas, Carlos A. ; Canizales-Quinteros, Samuel ; Menjivar, Marta ; Klitz, William ; Henderson, Brian ; Haiman, Christopher A. ; Winkler, Cheryl ; Tusie-Luna, Teresa ; Ruiz-Linares, Andrés ; Reich, David 

    2007-01-01

    Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America. PMID:17503322

  5. Optimal entrainment of heterogeneous noisy neurons.

    PubMed

    Wilson, Dan; Holt, Abbey B; Netoff, Theoden I; Moehlis, Jeff

    2015-01-01

    We develop a methodology to design a stimulus optimized to entrain nonlinear, noisy limit cycle oscillators with uncertain properties. Conditions are derived which guarantee that the stimulus will entrain the oscillators despite these uncertainties. Using these conditions, we develop an energy optimal control strategy to design an efficient entraining stimulus and apply it to numerical models of noisy phase oscillators and to in vitro hippocampal neurons. In both instances, the optimal stimuli outperform other similar but suboptimal entraining stimuli. Because this control strategy explicitly accounts for both noise and inherent uncertainty of model parameters, it could have experimental relevance to neural circuits where robust spike timing plays an important role.

  6. Partial entrainment of gravel bars during floods

    USGS Publications Warehouse

    Konrad, C.P.; Booth, D.B.; Burges, S.J.; Montgomery, D.R.

    2002-01-01

    Spatial patterns of bed material entrainment by floods were documented at seven gravel bars using arrays of metal washers (bed tags) placed in the streambed. The observed patterns were used to test a general stochastic model that bed material entrainment is a spatially independent, random process where the probability of entrainment is uniform over a gravel bar and a function of the peak dimensionless shear stress ??*0 of the flood. The fraction of tags missing from a gravel bar during a flood, or partial entrainment, had an approximately normal distribution with respect to ??*0 with a mean value (50% of the tags entrained) of 0.085 and standard deviation of 0.022 (root-mean-square error of 0.09). Variation in partial entrainment for a given ??*0 demonstrated the effects of flow conditioning on bed strength, with lower values of partial entrainment after intermediate magnitude floods (0.065 < ??*0 < 0.08) than after higher magnitude floods. Although the probability of bed material entrainment was approximately uniform over a gravel bar during individual floods and independent from flood to flood, regions of preferential stability and instability emerged at some bars over the course of a wet season. Deviations from spatially uniform and independent bed material entrainment were most pronounced for reaches with varied flow and in consecutive floods with small to intermediate magnitudes.

  7. Quantifying entrainment in pyroclastic density currents from the Tungurahua eruption, Ecuador: Integrating field proxies with numerical simulations

    NASA Astrophysics Data System (ADS)

    Benage, M. C.; Dufek, J.; Mothes, P. A.

    2016-07-01

    The entrainment of air into pyroclastic density currents (PDCs) impacts the dynamics and thermal history of these highly mobile currents. However, direct measurement of entrainment in PDCs is hampered due to hazardous conditions and opaqueness of these flows. We combine three-dimensional multiphase Eulerian-Eulerian-Lagrangian calculations with proxies of thermal conditions preserved in deposits to quantify air entrainment in PDCs at Tungurahua volcano, Ecuador. We conclude that small-volume PDCs develop a particle concentration gradient that results in disparate thermal characteristics for the concentrated bed load (>600 to ~800 K) and the overlying dilute suspended load (~300-600 K). The dilute suspended load has effective entrainment coefficients 2-3 times larger than the bed load. This investigation reveals a dichotomy in entrainment and thermal history between two regions in the current and provides a mechanism to interpret the depositional thermal characteristics of small-volume but frequently occurring PDCs.

  8. Entrainment instability and vertical motion as causes of stratocumulus breakup

    NASA Technical Reports Server (NTRS)

    Weaver, C. J.; Pearson, R., Jr.

    1990-01-01

    Entrainment instability is thought to be a cause of stratocumulus breakup. At the interface between the cloud and the overlying air, mixtures may form which are negatively buoyant because of cloud droplet evaporation. Quantities devised to predict breakup are obtained from aircraft observations and are tested against cloud observations from satellite. Often, the parameters indicate that breakup should occur but the clouds remain, sometimes for several days. One possible explanation for breakup is vertical motion from passing synoptic cyclones. Several cases suggest that breakup is associated with the downward vertical motion from the cold air advected behind an eastward moving cyclone.

  9. admixturegraph: an R package for admixture graph manipulation and fitting.

    PubMed

    Leppälä, Kalle; Nielsen, Svend V; Mailund, Thomas

    2017-06-01

    Admixture graphs generalize phylogenetic trees by allowing genetic lineages to merge as well as split. In this paper we present the R package admixturegraph containing tools for building and visualizing admixture graphs, for fitting graph parameters to genetic data, for visualizing goodness of fit and for evaluating the relative goodness of fit between different graphs. GitHub: https://github.com/mailund/admixture_graph and CRAN: https://cran.r-project.org/web/packages/admixturegraph . mailund@birc.au.dk .

  10. Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes–Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

    PubMed Central

    White, Marquitta J.; Oh, Sam S.; Thakur, Neeta; Galanter, Joshua M.; Nishimura, Katherine K.; Pino-Yanes, Maria; Torgerson, Dara G.; Gignoux, Christopher R.; Eng, Celeste; Nguyen, Elizabeth A.; Hu, Donglei; Mak, Angel C.; Kumar, Rajesh; Seibold, Max A.; Davis, Adam; Farber, Harold J.; Meade, Kelley; Avila, Pedro C.; Serebrisky, Denise; Lenoir, Michael A.; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Bibbins-Domingo, Kirsten; Thyne, Shannon M.; Williams, L. Keoki; Sen, Saunak; Gilliland, Frank D.; Gauderman, W. James; Rodriguez-Santana, Jose R.; Lurmann, Fred; Balmes, John R.; Eisen, Ellen A.; Burchard, Esteban G.

    2016-01-01

    Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods: The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter ≤10 μm and ≤2.5 μm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results: A 5 μg/m3 increase in average lifetime particulate matter less than or equal to 2.5 μm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval = −11.8 to −3.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers. PMID:26734713

  11. Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies.

    PubMed

    Neophytou, Andreas M; White, Marquitta J; Oh, Sam S; Thakur, Neeta; Galanter, Joshua M; Nishimura, Katherine K; Pino-Yanes, Maria; Torgerson, Dara G; Gignoux, Christopher R; Eng, Celeste; Nguyen, Elizabeth A; Hu, Donglei; Mak, Angel C; Kumar, Rajesh; Seibold, Max A; Davis, Adam; Farber, Harold J; Meade, Kelley; Avila, Pedro C; Serebrisky, Denise; Lenoir, Michael A; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Bibbins-Domingo, Kirsten; Thyne, Shannon M; Williams, L Keoki; Sen, Saunak; Gilliland, Frank D; Gauderman, W James; Rodriguez-Santana, Jose R; Lurmann, Fred; Balmes, John R; Eisen, Ellen A; Burchard, Esteban G

    2016-06-01

    Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking. To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter ≤10 μm and ≤2.5 μm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. A 5 μg/m(3) increase in average lifetime particulate matter less than or equal to 2.5 μm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval = -11.8 to -3.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function. Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.

  12. Skin pigmentation, biogeographical ancestry and admixture mapping.

    PubMed

    Shriver, Mark D; Parra, Esteban J; Dios, Sonia; Bonilla, Carolina; Norton, Heather; Jovel, Celina; Pfaff, Carrie; Jones, Cecily; Massac, Aisha; Cameron, Neil; Baron, Archie; Jackson, Tabitha; Argyropoulos, George; Jin, Li; Hoggart, Clive J; McKeigue, Paul M; Kittles, Rick A

    2003-04-01

    Ancestry informative markers (AIMs) are genetic loci showing alleles with large frequency differences between populations. AIMs can be used to estimate biogeographical ancestry at the level of the population, subgroup (e.g. cases and controls) and individual. Ancestry estimates at both the subgroup and individual level can be directly instructive regarding the genetics of the phenotypes that differ qualitatively or in frequency between populations. These estimates can provide a compelling foundation for the use of admixture mapping (AM) methods to identify the genes underlying these traits. We present details of a panel of 34 AIMs and demonstrate how such studies can proceed, by using skin pigmentation as a model phenotype. We have genotyped these markers in two population samples with primarily African ancestry, viz. African Americans from Washington D.C. and an African Caribbean sample from Britain, and in a sample of European Americans from Pennsylvania. In the two African population samples, we observed significant correlations between estimates of individual ancestry and skin pigmentation as measured by reflectometry (R(2)=0.21, P<0.0001 for the African-American sample and R(2)=0.16, P<0.0001 for the British African-Caribbean sample). These correlations confirm the validity of the ancestry estimates and also indicate the high level of population structure related to admixture, a level that characterizes these populations and that is detectable by using other tests to identify genetic structure. We have also applied two methods of admixture mapping to test for the effects of three candidate genes (TYR, OCA2, MC1R) on pigmentation. We show that TYR and OCA2 have measurable effects on skin pigmentation differences between the west African and west European parental populations. This work indicates that it is possible to estimate the individual ancestry of a person based on DNA analysis with a reasonable number of well-defined genetic markers. The implications and

  13. The entrainment rate for a row of turbulent jets. M.S. Thesis Final Report

    NASA Technical Reports Server (NTRS)

    Gordon, Eliott B.; Greber, Isaac

    1990-01-01

    Entrainment rates for a row of isothermal circular air jets issuing into a quiescent environment are found by integrating velocity distributions measured by a linearized hot-wire anemometer. Jet spacing to jet diameter ratios of 2.5, 5, 10, and 20 are studied at jet Reynold's numbers ranging from 5110 to 12070. Velocity distributions are determined at regular downstream intervals at axial distances equal to 16.4 to 164 jet diameters from the jet source. The entrainment rates for the four spacing configurations vary monotonically with increasing spacing/diameter between the limiting case of the slot jet entrainment rate (where the jet spacing to diameter ratio is zero) and the circular jet entrainment rate (in which the spacing to diameter ratio is infinity).

  14. Fluid entrainment by isolated vortex rings

    NASA Astrophysics Data System (ADS)

    Dabiri, John O.; Gharib, Morteza

    2004-07-01

    Of particular importance to the development of models for isolated vortex ring dynamics in a real fluid is knowledge of ambient fluid entrainment by the ring. This time-dependent process dictates changes in the volume of fluid that must share impulse delivered by the vortex ring generator. Therefore fluid entrainment is also of immediate significance to the unsteady forces that arise due to the presence of vortex rings in starting flows. Applications ranging from industrial and transportation, to animal locomotion and cardiac flows, are currently being investigated to understand the dynamical role of the observed vortex ring structures. Despite this growing interest, fully empirical measurements of fluid entrainment by isolated vortex rings have remained elusive. The primary difficulties arise in defining the unsteady boundary of the ring, as well as an inability to maintain the vortex ring in the test section sufficiently long to facilitate measurements. We present a new technique for entrainment measurement that utilizes a coaxial counter-flow to retard translation of vortex rings generated from a piston cylinder apparatus, so that their growth due to fluid entrainment can be observed. Instantaneous streamlines of the flow are used to determine the unsteady vortex ring boundary and compute ambient fluid entrainment. Measurements indicate that the entrainment process does not promote self-similar vortex ring growth, but instead consists of a rapid convection-based entrainment phase during ring formation, followed by a slower diffusive mechanism that entrains ambient fluid into the isolated vortex ring. Entrained fluid typically constitutes 30% to 40% of the total volume of fluid carried with the vortex ring. Various counter-flow protocols were used to substantially manipulate the diffusive entrainment process, producing rings with entrained fluid fractions up to 65%. Measurements of vortex ring growth rate and vorticity distribution during diffusive entrainment

  15. Ancestry, admixture and fitness in Colombian genomes.

    PubMed

    Rishishwar, Lavanya; Conley, Andrew B; Wigington, Charles H; Wang, Lu; Valderrama-Aguirre, Augusto; Jordan, I King

    2015-07-21

    The human dimension of the Columbian Exchange entailed substantial genetic admixture between ancestral source populations from Africa, the Americas and Europe, which had evolved separately for many thousands of years. We sought to address the implications of the creation of admixed American genomes, containing novel allelic combinations, for human health and fitness via analysis of an admixed Colombian population from Medellin. Colombian genomes from Medellin show a wide range of three-way admixture contributions from ancestral source populations. The primary ancestry component for the population is European (average = 74.6%, range = 45.0%-96.7%), followed by Native American (average = 18.1%, range = 2.1%-33.3%) and African (average = 7.3%, range = 0.2%-38.6%). Locus-specific patterns of ancestry were evaluated to search for genomic regions that are enriched across the population for particular ancestry contributions. Adaptive and innate immune system related genes and pathways are particularly over-represented among ancestry-enriched segments, including genes (HLA-B and MAPK10) that are involved in defense against endemic pathogens such as malaria. Genes that encode functions related to skin pigmentation (SCL4A5) and cutaneous glands (EDAR) are also found in regions with anomalous ancestry patterns. These results suggest the possibility that ancestry-specific loci were differentially retained in the modern admixed Colombian population based on their utility in the New World environment.

  16. Admixture, Population Structure, and F-Statistics.

    PubMed

    Peter, Benjamin M

    2016-04-01

    Many questions about human genetic history can be addressed by examining the patterns of shared genetic variation between sets of populations. A useful methodological framework for this purpose isF-statistics that measure shared genetic drift between sets of two, three, and four populations and can be used to test simple and complex hypotheses about admixture between populations. This article provides context from phylogenetic and population genetic theory. I review how F-statistics can be interpreted as branch lengths or paths and derive new interpretations, using coalescent theory. I further show that the admixture tests can be interpreted as testing general properties of phylogenies, allowing extension of some ideas applications to arbitrary phylogenetic trees. The new results are used to investigate the behavior of the statistics under different models of population structure and show how population substructure complicates inference. The results lead to simplified estimators in many cases, and I recommend to replace F3 with the average number of pairwise differences for estimating population divergence. Copyright © 2016 by the Genetics Society of America.

  17. Entrainment rates and microphysics in POST stratocumulus

    NASA Astrophysics Data System (ADS)

    Gerber, H.; Frick, G.; Malinowski, Szymon P.; Jonsson, H.; Khelif, D.; Krueger, Steven K.

    2013-11-01

    An aircraft field study (POST; Physics of Stratocumulus Top) was conducted off the central California coast in July and August 2008 to deal with the known difficulty of measuring entrainment rates in the radiatively important stratocumulus (Sc) prevalent in that area. The Center for Interdisciplinary Remotely-Piloted Aircraft Studies Twin Otter research aircraft flew 15 quasi-Lagrangian flights in unbroken Sc and carried a full complement of probes including three high-data-rate probes: ultrafast temperature probe, particulate volume monitor probe, and gust probe. The probes' colocation near the nose of the Twin Otter permitted estimation of entrainment fluxes and rates with an in-cloud resolution of 1 m. Results include the following: Application of the conditional sampling variation of classical mixed layer theory for calculating the entrainment rate into cloud top for POST flights is shown to be inadequate for most of the Sc. Estimated rates resemble previous results after theory is modified to take into account both entrainment and evaporation at cloud top given the strong wind shear and mixing at cloud top. Entrainment rates show a tendency to decrease for large shear values, and the largest rates are for the smallest temperature jumps across the inversion. Measurements indirectly suggest that entrained parcels are primarily cooled by infrared flux divergence rather than cooling from droplet evaporation, while detrainment at cloud top causes droplet evaporation and cooling in the entrainment interface layer above cloud top.

  18. Temperature compensation and entrainment in circadian rhythms

    NASA Astrophysics Data System (ADS)

    Bodenstein, C.; Heiland, I.; Schuster, S.

    2012-06-01

    To anticipate daily variations in the environment and coordinate biological activities into a daily cycle many organisms possess a circadian clock. In the absence of external time cues the circadian rhythm persists with a period of approximately 24 h. The clock phase can be shifted by single pulses of light, darkness, chemicals, or temperature and this allows entrainment of the clock to exactly 24 h by cycles of these zeitgebers. On the other hand, the period of the circadian rhythm is kept relatively constant within a physiological range of constant temperatures, which means that the oscillator is temperature compensated. The mechanisms behind temperature compensation and temperature entrainment are not fully understood, neither biochemically nor mathematically. Here, we theoretically investigate the interplay of temperature compensation and entrainment in general oscillatory systems. We first give an analytical treatment for small temperature shifts and derive that every temperature-compensated oscillator is entrainable to external small-amplitude temperature cycles. Temperature compensation ensures that this entrainment region is always centered at the endogenous period regardless of possible seasonal temperature differences. Moreover, for small temperature cycles the entrainment region of the oscillator is potentially larger for rectangular pulses. For large temperature shifts we numerically analyze different circadian clock models proposed in the literature with respect to these properties. We observe that for such large temperature shifts sinusoidal or gradual temperature cycles allow a larger entrainment region than rectangular cycles.

  19. Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium

    PubMed Central

    Loh, Po-Ru; Lipson, Mark; Patterson, Nick; Moorjani, Priya; Pickrell, Joseph K.; Reich, David; Berger, Bonnie

    2013-01-01

    Long-range migrations and the resulting admixtures between populations have been important forces shaping human genetic diversity. Most existing methods for detecting and reconstructing historical admixture events are based on allele frequency divergences or patterns of ancestry segments in chromosomes of admixed individuals. An emerging new approach harnesses the exponential decay of admixture-induced linkage disequilibrium (LD) as a function of genetic distance. Here, we comprehensively develop LD-based inference into a versatile tool for investigating admixture. We present a new weighted LD statistic that can be used to infer mixture proportions as well as dates with fewer constraints on reference populations than previous methods. We define an LD-based three-population test for admixture and identify scenarios in which it can detect admixture events that previous formal tests cannot. We further show that we can uncover phylogenetic relationships among populations by comparing weighted LD curves obtained using a suite of references. Finally, we describe several improvements to the computation and fitting of weighted LD curves that greatly increase the robustness and speed of the calculations. We implement all of these advances in a software package, ALDER, which we validate in simulations and apply to test for admixture among all populations from the Human Genome Diversity Project (HGDP), highlighting insights into the admixture history of Central African Pygmies, Sardinians, and Japanese. PMID:23410830

  20. Informativeness of the CODIS STR loci for admixture analysis.

    PubMed

    Barnholtz-Sloan, Jill S; Pfaff, Carrie L; Chakraborty, Ranajit; Long, Jeffrey C

    2005-11-01

    Population admixture (or ancestry) is used as an approach to gene discovery in complex diseases, particularly when the disease prevalence varies widely across geographic populations. Admixture analysis could be useful for forensics because an indication of a perpetrator's ancestry would narrow the pool of suspects for a particular crime. The purpose of this study was to use Fisher's information to identify informative sets of markers for admixture analysis. Using published founding population allele frequencies we test three marker sets for efficacy for estimating admixture: the FBI CODIS Core STR loci, the HGDP-CEPH Human Genome Diversity Cell Line Panel and the set of 39 ancestry informative SNPS from the Shriver lab at Pennsylvania State University. We conclude that the FBI CODIS Core STR set is valid for admixture analysis, but not the most precise. We recommend using a combination of the most informative markers from the HGDP-CEPH and Shriver loci sets.

  1. A Quantitative Investigation of Entrainment and Detrainment in Numerically Simulated Convective Clouds. Pt. 1; Model Development

    NASA Technical Reports Server (NTRS)

    Cohen, Charles

    1998-01-01

    A method is developed which uses numerical tracers to make accurate diagnoses of entraimnent and detrainment rates and of the properties of the entrained and detrained air in numerically simulated clouds. The numerical advection scheme is modified to make it nondispersive, as required by the use of the tracers. Tests of the new method are made, and an appropriate definition of clouds is selected. Distributions of mixing fractions in the model consistently show maximums at the end points, for nearly undilute environmental air or nearly undilute cloud air, with a uniform distribution between. The cumulonimbus clouds simulated here entrain air that had been substantially changed by the clouds, and detrained air that is not necessarily representative of the cloud air at the same level.

  2. Genetic admixture, self-reported ethnicity, self-estimated admixture, and skin pigmentation among Hispanics and Native Americans.

    PubMed

    Klimentidis, Yann C; Miller, Geoffrey F; Shriver, Mark D

    2009-04-01

    The relationship between ethnicity and biology is of interest to anthropologists, biomedical scientists, and historians in understanding how human groups are constructed. Ethnic self-identification in recently admixed groups such as Hispanics, African Americans, and Native Americans (NA) is likely to be complex due to the heterogeneity in individual admixture proportions and social environments within these groups. This study examines the relationships between self-identified ethnicity, self-estimated admixture proportions, skin pigmentation, and genetic marker estimated admixture proportions. These measures were assessed using questionnaires, skin color measurements, and genotyping of a panel of 76 ancestry informative markers, among 170 Hispanics and NAs from New Mexico, a state known for its complex history of interactions between people of NA and European (EU) ancestry. Results reveal that NAs underestimate their degree of EU admixture, and that Hispanics underestimate their degree of NA admixture. Within Hispanics, genetic-marker estimated admixture is better predicted by forehead skin pigmentation than by self-estimated admixture. We also find that Hispanic individuals self-identified as "half-White, half Hispanic" and "Spanish" have lower levels of NA admixture than those self-identified as "Mexican" and "Mexican American." Such results highlight the interplay between culture and biology in how individuals identify and view themselves, and have implications for how ethnicity and disease risk are assessed in a medical setting.

  3. Eyeblink entrainment at breakpoints of speech.

    PubMed

    Nakano, Tamami; Kitazawa, Shigeru

    2010-09-01

    The eyes play an essential role in social communication. Eyeblinks, however, have thus far received minor attention. We previously showed that subjects blink in synchrony while viewing the same video stories (Nakano et al. in Proc R Soc B 276:3635-3644, 2009). We therefore hypothesized that eyeblinks are synchronized between listener and speaker in face-to-face conversation. Here, we show that listeners blinked with a delay of 0.25-0.5 s after the speaker blinked when the listeners viewed close-up video clips (with sound) of the speaker's face. Furthermore, this entrainment was selectively triggered by speaker's eyeblinks occurring at the end and during pauses in speech. Eyeblink entrainment was not observed when viewing identical video clips without sound, indicating that blink entrainment was not an automatic imitation. We therefore suggest that eyeblink entrainment reflects smooth communication between interactants.

  4. Washing of the AN-107 entrained solids

    SciTech Connect

    GJ Lumetta; FV Hoopes

    2000-03-31

    This report describes the results of a test conducted by Battelle to assess the effects of inhibited water washing on the composition of the entrained solids in the diluted AN-107 low-activity waste (LAW) sample. The objective of this work was to gather data on the solubility of the AN-107 entrained solids in 0.01 M NaOH, so that BNFL can evaluate whether these solids require caustic leaching.

  5. Visual cortex entrains to sign language.

    PubMed

    Brookshire, Geoffrey; Lu, Jenny; Nusbaum, Howard C; Goldin-Meadow, Susan; Casasanto, Daniel

    2017-06-13

    Despite immense variability across languages, people can learn to understand any human language, spoken or signed. What neural mechanisms allow people to comprehend language across sensory modalities? When people listen to speech, electrophysiological oscillations in auditory cortex entrain to slow ([Formula: see text]8 Hz) fluctuations in the acoustic envelope. Entrainment to the speech envelope may reflect mechanisms specialized for auditory perception. Alternatively, flexible entrainment may be a general-purpose cortical mechanism that optimizes sensitivity to rhythmic information regardless of modality. Here, we test these proposals by examining cortical coherence to visual information in sign language. First, we develop a metric to quantify visual change over time. We find quasiperiodic fluctuations in sign language, characterized by lower frequencies than fluctuations in speech. Next, we test for entrainment of neural oscillations to visual change in sign language, using electroencephalography (EEG) in fluent speakers of American Sign Language (ASL) as they watch videos in ASL. We find significant cortical entrainment to visual oscillations in sign language <5 Hz, peaking at [Formula: see text]1 Hz. Coherence to sign is strongest over occipital and parietal cortex, in contrast to speech, where coherence is strongest over the auditory cortex. Nonsigners also show coherence to sign language, but entrainment at frontal sites is reduced relative to fluent signers. These results demonstrate that flexible cortical entrainment to language does not depend on neural processes that are specific to auditory speech perception. Low-frequency oscillatory entrainment may reflect a general cortical mechanism that maximizes sensitivity to informational peaks in time-varying signals.

  6. Neurophysiological Analysis of Circadian Rhythm Entrainment

    DTIC Science & Technology

    1994-05-24

    the newly discovered 5 - HT7 receptor have yet to be performed. These results demonstrate that serotonin acting through a 5 -HTIA-like receptor can...ANNUAL 1 Jan 93 TO 31 Dec 93 4. TITLE AND SUBTITLE 5 . FUNDING NUMBERS NEUROPHYSIOLOGICAL ANALYSIS OF CIRCADIAN RHYTHM F49620-93-1-0089 ENTRAINMENT j...sensitivity of SCN cells to serotonin ( 5 -HT) and the effects of serotonin on rhythm entrainment. The evidence to date has suggested, however, that

  7. Simulation study on factors influencing the entrainment behavior of liquid steel as bubbles pass through the steel/slag interface

    NASA Astrophysics Data System (ADS)

    Li, Xiang; Bao, Yan-ping; Wang, Min; Lin, Lu

    2016-05-01

    In this study, a water/silicone oil interface was used to simulate the steel/slag interface in a converter. A high-speed camera was used to record the entrainment process of droplets when air bubbles were passed through the water/silicone oil interface. Motion parameters of the bubbles and droplets were obtained using particle kinematic analysis software, and the entrainment rate of the droplets was calculated. It was found that the entrainment rate decreased from 29.5% to 0 when the viscosity of the silicone oil was increased from 60 mPa·s to 820 mPa·s in the case of bubbles with a 5 mm equivalent diameter passing through the water/silicone oil interface. The results indicate that increasing the viscosity of the silicone oil is conducive to reducing the entrainment rate. The entrainment rate increased from 0 to 136.3% in the case of silicone oil with a viscosity of 60 mPa·s when the equivalent diameter of the bubbles was increased from 3 mm to 7 mm. We therefore conclude that small bubbles are also conductive to reducing the entrainment rate. The force analysis results for the water column indicate that the entrainment rate of droplets is affected by the velocity of the bubble passing through the water/silicone oil interface and that the entrainment rate decreases with the bubble velocity.

  8. Air

    MedlinePlus

    ... do to protect yourself from dirty air . Indoor air pollution and outdoor air pollution Air can be polluted indoors and it can ... this chart to see what things cause indoor air pollution and what things cause outdoor air pollution! Indoor ...

  9. Ancestry, admixture and fitness in Colombian genomes

    PubMed Central

    Rishishwar, Lavanya; Conley, Andrew B.; Wigington, Charles H.; Wang, Lu; Valderrama-Aguirre, Augusto; King Jordan, I.

    2015-01-01

    The human dimension of the Columbian Exchange entailed substantial genetic admixture between ancestral source populations from Africa, the Americas and Europe, which had evolved separately for many thousands of years. We sought to address the implications of the creation of admixed American genomes, containing novel allelic combinations, for human health and fitness via analysis of an admixed Colombian population from Medellin. Colombian genomes from Medellin show a wide range of three-way admixture contributions from ancestral source populations. The primary ancestry component for the population is European (average = 74.6%, range = 45.0%–96.7%), followed by Native American (average = 18.1%, range = 2.1%–33.3%) and African (average = 7.3%, range = 0.2%–38.6%). Locus-specific patterns of ancestry were evaluated to search for genomic regions that are enriched across the population for particular ancestry contributions. Adaptive and innate immune system related genes and pathways are particularly over-represented among ancestry-enriched segments, including genes (HLA-B and MAPK10) that are involved in defense against endemic pathogens such as malaria. Genes that encode functions related to skin pigmentation (SCL4A5) and cutaneous glands (EDAR) are also found in regions with anomalous ancestry patterns. These results suggest the possibility that ancestry-specific loci were differentially retained in the modern admixed Colombian population based on their utility in the New World environment. PMID:26197429

  10. Genetic evidence for archaic admixture in Africa.

    PubMed

    Hammer, Michael F; Woerner, August E; Mendez, Fernando L; Watkins, Joseph C; Wall, Jeffrey D

    2011-09-13

    A long-debated question concerns the fate of archaic forms of the genus Homo: did they go extinct without interbreeding with anatomically modern humans, or are their genes present in contemporary populations? This question is typically focused on the genetic contribution of archaic forms outside of Africa. Here we use DNA sequence data gathered from 61 noncoding autosomal regions in a sample of three sub-Saharan African populations (Mandenka, Biaka, and San) to test models of African archaic admixture. We use two complementary approximate-likelihood approaches and a model of human evolution that involves recent population structure, with and without gene flow from an archaic population. Extensive simulation results reject the null model of no admixture and allow us to infer that contemporary African populations contain a small proportion of genetic material (≈ 2%) that introgressed ≈ 35 kya from an archaic population that split from the ancestors of anatomically modern humans ≈ 700 kya. Three candidate regions showing deep haplotype divergence, unusual patterns of linkage disequilibrium, and small basal clade size are identified and the distributions of introgressive haplotypes surveyed in a sample of populations from across sub-Saharan Africa. One candidate locus with an unusual segment of DNA that extends for >31 kb on chromosome 4 seems to have introgressed into modern Africans from a now-extinct taxon that may have lived in central Africa. Taken together our results suggest that polymorphisms present in extant populations introgressed via relatively recent interbreeding with hominin forms that diverged from the ancestors of modern humans in the Lower-Middle Pleistocene.

  11. Entrainment of peripheral clock genes by cortisol

    PubMed Central

    Mavroudis, Panteleimon D.; Scheff, Jeremy D.; Calvano, Steve E.; Lowry, Stephen F.

    2012-01-01

    Circadian rhythmicity in mammals is primarily driven by the suprachiasmatic nucleus (SCN), often called the central pacemaker, which converts the photic information of light and dark cycles into neuronal and hormonal signals in the periphery of the body. Cells of peripheral tissues respond to these centrally mediated cues by adjusting their molecular function to optimize organism performance. Numerous systemic cues orchestrate peripheral rhythmicity, such as feeding, body temperature, the autonomic nervous system, and hormones. We propose a semimechanistic model for the entrainment of peripheral clock genes by cortisol as a representative entrainer of peripheral cells. This model demonstrates the importance of entrainer's characteristics in terms of the synchronization and entrainment of peripheral clock genes, and predicts the loss of intercellular synchrony when cortisol moves out of its homeostatic amplitude and frequency range, as has been observed clinically in chronic stress and cancer. The model also predicts a dynamic regime of entrainment, when cortisol has a slightly decreased amplitude rhythm, where individual clock genes remain relatively synchronized among themselves but are phase shifted in relation to the entrainer. The model illustrates how the loss of communication between the SCN and peripheral tissues could result in desynchronization of peripheral clocks. PMID:22510707

  12. Tuning the phase of circadian entrainment.

    PubMed

    Bordyugov, Grigory; Abraham, Ute; Granada, Adrian; Rose, Pia; Imkeller, Katharina; Kramer, Achim; Herzel, Hanspeter

    2015-07-06

    The circadian clock coordinates daily physiological, metabolic and behavioural rhythms. These endogenous oscillations are synchronized with external cues ('zeitgebers'), such as daily light and temperature cycles. When the circadian clock is entrained by a zeitgeber, the phase difference ψ between the phase of a clock-controlled rhythm and the phase of the zeitgeber is of fundamental importance for the fitness of the organism. The phase of entrainment ψ depends on the mismatch between the intrinsic period τ and the zeitgeber period T and on the ratio of the zeitgeber strength to oscillator amplitude. Motivated by the intriguing complexity of empirical data and by our own experiments on temperature entrainment of mouse suprachiasmatic nucleus (SCN) slices, we present a theory on how clock and zeitgeber properties determine the phase of entrainment. The wide applicability of the theory is demonstrated using mathematical models of different complexity as well as by experimental data. Predictions of the theory are confirmed by published data on Neurospora crassa strains for different period mismatches τ - T and varying photoperiods. We apply a novel regression technique to analyse entrainment of SCN slices by temperature cycles. We find that mathematical models can explain not only the stable asymptotic phase of entrainment, but also transient phase dynamics. Our theory provides the potential to explore seasonal variations of circadian rhythms, jet lag and shift work in forthcoming studies.

  13. Ambient Fluid Entrainment by Vortex Ring Formation

    NASA Astrophysics Data System (ADS)

    Olcay, Ali B.; Krueger, Paul S.

    2004-11-01

    During the formation of a vortex ring from a piston-cylinder mechanism, the roll-up of the ejected shear layer entrains ambient fluid. The resulting vortex ring convects both ejected and ambient fluid downstream. Ambient fluid entrained during the formation phase must be accelerated with the forming ring and can contribute to elevated propulsive effectiveness for pulsed-jet propulsion. In this regard it is of interest to know how much ambient fluid is entrained during vortex ring formation and if the entrainment occurs primarily during jet ejection or afterward. The present investigation evaluates ambient fluid entrainment experimentally using laser induced fluorescence of vortex ring formation from a piston-cylinder vortex ring generator. The fraction of ambient fluid in fully-developed vortex rings is evaluated directly for piston stroke-to-diameter (L/D) ratios in the range 0.25 to 4 for jet Reynolds number in the range 500 to 2000. The results indicate that the ambient fluid fraction is greater than 50% for L/D < 2.0, and the fraction tends to decrease as L/D increases. Time evolution of the entrainment during ring formation will also be presented.

  14. Coupling governs entrainment range of circadian clocks.

    PubMed

    Abraham, Ute; Granada, Adrián E; Westermark, Pål O; Heine, Markus; Kramer, Achim; Herzel, Hanspeter

    2010-11-30

    Circadian clocks are endogenous oscillators driving daily rhythms in physiology and behavior. Synchronization of these timers to environmental light-dark cycles ('entrainment') is crucial for an organism's fitness. Little is known about which oscillator qualities determine entrainment, i.e., entrainment range, phase and amplitude. In a systematic theoretical and experimental study, we uncovered these qualities for circadian oscillators in the suprachiasmatic nucleus (SCN-the master clock in mammals) and the lung (a peripheral clock): (i) the ratio between stimulus (zeitgeber) strength and oscillator amplitude and (ii) the rigidity of the oscillatory system (relaxation rate upon perturbation) determine entrainment properties. Coupling among oscillators affects both qualities resulting in increased amplitude and rigidity. These principles explain our experimental findings that lung clocks entrain to extreme zeitgeber cycles, whereas SCN clocks do not. We confirmed our theoretical predictions by showing that pharmacological inhibition of coupling in the SCN leads to larger ranges of entrainment. These differences between master and the peripheral clocks suggest that coupling-induced rigidity in the SCN filters environmental noise to create a robust circadian system.

  15. Tuning the phase of circadian entrainment

    PubMed Central

    Bordyugov, Grigory; Abraham, Ute; Granada, Adrian; Rose, Pia; Imkeller, Katharina; Kramer, Achim; Herzel, Hanspeter

    2015-01-01

    The circadian clock coordinates daily physiological, metabolic and behavioural rhythms. These endogenous oscillations are synchronized with external cues (‘zeitgebers’), such as daily light and temperature cycles. When the circadian clock is entrained by a zeitgeber, the phase difference ψ between the phase of a clock-controlled rhythm and the phase of the zeitgeber is of fundamental importance for the fitness of the organism. The phase of entrainment ψ depends on the mismatch between the intrinsic period τ and the zeitgeber period T and on the ratio of the zeitgeber strength to oscillator amplitude. Motivated by the intriguing complexity of empirical data and by our own experiments on temperature entrainment of mouse suprachiasmatic nucleus (SCN) slices, we present a theory on how clock and zeitgeber properties determine the phase of entrainment. The wide applicability of the theory is demonstrated using mathematical models of different complexity as well as by experimental data. Predictions of the theory are confirmed by published data on Neurospora crassa strains for different period mismatches τ − T and varying photoperiods. We apply a novel regression technique to analyse entrainment of SCN slices by temperature cycles. We find that mathematical models can explain not only the stable asymptotic phase of entrainment, but also transient phase dynamics. Our theory provides the potential to explore seasonal variations of circadian rhythms, jet lag and shift work in forthcoming studies. PMID:26136227

  16. Coupling governs entrainment range of circadian clocks

    PubMed Central

    Abraham, Ute; Granada, Adrián E; Westermark, Pål O; Heine, Markus; Kramer, Achim; Herzel, Hanspeter

    2010-01-01

    Circadian clocks are endogenous oscillators driving daily rhythms in physiology and behavior. Synchronization of these timers to environmental light–dark cycles (‘entrainment') is crucial for an organism's fitness. Little is known about which oscillator qualities determine entrainment, i.e., entrainment range, phase and amplitude. In a systematic theoretical and experimental study, we uncovered these qualities for circadian oscillators in the suprachiasmatic nucleus (SCN—the master clock in mammals) and the lung (a peripheral clock): (i) the ratio between stimulus (zeitgeber) strength and oscillator amplitude and (ii) the rigidity of the oscillatory system (relaxation rate upon perturbation) determine entrainment properties. Coupling among oscillators affects both qualities resulting in increased amplitude and rigidity. These principles explain our experimental findings that lung clocks entrain to extreme zeitgeber cycles, whereas SCN clocks do not. We confirmed our theoretical predictions by showing that pharmacological inhibition of coupling in the SCN leads to larger ranges of entrainment. These differences between master and the peripheral clocks suggest that coupling-induced rigidity in the SCN filters environmental noise to create a robust circadian system. PMID:21119632

  17. Analysis of admixture and genetic structure of two Native American groups of Southern Argentinean Patagonia.

    PubMed

    Sala, Andrea; Corach, Daniel

    2014-03-01

    Argentinean Patagonia is inhabited by people that live principally in urban areas and by small isolated groups of individuals that belong to indigenous aboriginal groups; this territory exhibits the lowest population density of the country. Mapuche and Tehuelche (Mapudungun linguistic branch), are the only extant Native American groups that inhabit the Argentinean Patagonian provinces of Río Negro and Chubut. Fifteen autosomal STRs, 17 Y-STRs, mtDNA full length control region sequence and two sets of Y and mtDNA-coding region SNPs were analyzed in a set of 434 unrelated individuals. The sample set included two aboriginal groups, a group of individuals whose family name included Native American linguistic root and urban samples from Chubut, Río Negro and Buenos Aires provinces of Argentina. Specific Y Amerindian haplogroup Q1 was found in 87.5% in Mapuche and 58.82% in Tehuelche, while the Amerindian mtDNA haplogroups were present in all the aboriginal sample contributors investigated. Admixture analysis performed by means of autosomal and Y-STRs showed the highest degree of admixture in individuals carrying Mapuche surnames, followed by urban populations, and finally by isolated Native American populations as less degree of admixture. The study provided novel genetic information about the Mapuche and Tehuelche people and allowed us to establish a genetic correlation among individuals with Mapudungun surnames that demonstrates not only a linguistic but also a genetic relationship to the isolated aboriginal communities, representing a suitable proxy indicator for assessing genealogical background.

  18. State of the art: regional anesthesia using anesthetic admixtures.

    PubMed

    Fetzer-Fowler, S

    1992-08-01

    Aging, high-risk, and ambulatory patients comprise a growing population of surgical candidates. The advantages of regional anesthesia for these patients has promoted technological and pharmacological advances. As new anesthetic agents are developed, methods to improve existing local anesthetics continue. This article reviews the current practice of local anesthetic admixtures. The physiological action of the local anesthetics and their additives is explained relative to their chemical properties. The advantages and risks when adding bicarbonate and epinephrine are described. Nursing implications for the care of the patient receiving regional anesthesia using admixtures are reviewed. An actual case report is presented to demonstrate the clinical application of local anesthetic admixtures.

  19. Scale-dependent entrainment velocity and scale-independent net entrainment in a turbulent axisymmetric jet

    NASA Astrophysics Data System (ADS)

    Philip, Jimmy; Mistry, Dhiren; Dawson, James; Marusic, Ivan

    2016-11-01

    The net entrainment in a jet is the product of the mean surface area (S ̲) and the mean entrainment velocity, V ̲ S ̲ , where, V ̲ = αUc with α the entrainment coefficient and Uc the mean centreline velocity. Instantaneously, however, entrainment velocity (v) at a point on the interface is the difference between the interface and the fluid velocities, and the total entrainment ∫ vds = VS , where S is the corrugated interface surface area and V the area averaged entrainment velocity. Using time-resolved multi-scale PIV/PLIF measurements of velocity and scalar in an axisymmetric jet at Re = 25000 , we evaluate V and S directly at the smallest resolved scales, and by filtering the data at different scales (Δ) we find their multi-scales counterparts, VΔ and SΔ. We show that V ̲ S ̲ =VΔ SΔ = V S , independent of the scale. Furthermore, S is found to have a fractal dimension D3 2 . 32 +/- 0 . 1 . Independently, we find that VΔ Δ 0 . 31 , indicating increasing entrainment velocity with increasing length scale. This is consistent with a constant net entrainment across scales, and suggests α as a scale-dependent quantity. Engineering and Physical Sciences Research Council (research Grant No. EP/I005879/1), David Crighton Fellowship from the DAMTP, Univ of Cambridge, and the Australian Research Council.

  20. Observational estimates of detrainment and entrainment in non-precipitating shallow cumulus

    NASA Astrophysics Data System (ADS)

    Norgren, M. S.; Small, J. D.; Jonsson, H. H.; Chuang, P. Y.

    2014-08-01

    Vertical transport associated with cumulus clouds is important to the redistribution of gases, particles and energy, with subsequent consequences for many aspects of the climate system. Previous studies have suggested that detrainment from clouds can be comparable to the updraft mass flux, and thus represents an important contribution to vertical transport. In this study, we describe a new method to deduce the amounts of gross detrainment and entrainment experienced by non-precipitating cumulus clouds using aircraft observations. The method utilizes equations for three conserved variables: cloud mass, total water and moist static energy. Optimizing these three equations leads to estimates of the mass fractions of adiabatic mixed-layer air, entrained air and detrained air that the sampled cloud has experienced. The method is applied to six flights of the CIRPAS Twin Otter during the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) which took place in the Houston, Texas region during the summer of 2006 during which 176 small, non-precipitating cumulus were sampled. Our analysis suggests that, on average, these clouds were comprised of 30 to 70% mixed-layer air, with entrained air comprising most of the remainder. The mass fraction of detrained air was less than 2% for a majority of the clouds, although 15% of them did exhibit detrained air fractions larger than 10%. Entrained and detrained air mass fractions both increased with altitude, and the largest detrainment events were almost all associated with air that was at their level of neutral buoyancy, findings that are consistent with previous studies.

  1. Nonphotic entrainment of the human circadian pacemaker

    NASA Technical Reports Server (NTRS)

    Klerman, E. B.; Rimmer, D. W.; Dijk, D. J.; Kronauer, R. E.; Rizzo, J. F. 3rd; Czeisler, C. A.

    1998-01-01

    In organisms as diverse as single-celled algae and humans, light is the primary stimulus mediating entrainment of the circadian biological clock. Reports that some totally blind individuals appear entrained to the 24-h day have suggested that nonphotic stimuli may also be effective circadian synchronizers in humans, although the nonphotic stimuli are probably comparatively weak synchronizers, because the circadian rhythms of many totally blind individuals "free run" even when they maintain a 24-h activity-rest schedule. To investigate entrainment by nonphotic synchronizers, we studied the endogenous circadian melatonin and core body temperature rhythms of 15 totally blind subjects who lacked conscious light perception and exhibited no suppression of plasma melatonin in response to ocular bright-light exposure. Nine of these fifteen blind individuals were able to maintain synchronization to the 24-h day, albeit often at an atypical phase angle of entrainment. Nonphotic stimuli also synchronized the endogenous circadian rhythms of a totally blind individual to a non-24-h schedule while living in constant near darkness. We conclude that nonphotic stimuli can entrain the human circadian pacemaker in some individuals lacking ocular circadian photoreception.

  2. Entrainment and the cranial rhythmic impulse.

    PubMed

    McPartland, J M; Mein, E A

    1997-01-01

    Entrainment is the integration or harmonization of oscillators. All organisms pulsate with myriad electrical and mechanical rhythms. Many of these rhythms emanate from synchronized pulsating cells (eg, pacemaker cells, cortical neurons). The cranial rhythmic impulse is an oscillation recognized by many bodywork practitioners, but the functional origin of this impulse remains uncertain. We propose that the cranial rhythmic impulse is the palpable perception of entrainment, a harmonic frequency that incorporates the rhythms of multiple biological oscillators. It is derived primarily from signals between the sympathetic and parasympathetic nervous systems. Entrainment also arises between organisms. The harmonizing of coupled oscillators into a single, dominant frequency is called frequency-selective entrainment. We propose that this phenomenon is the modus operandi of practitioners who use the cranial rhythmic impulse in craniosacral treatment. Dominant entrainment is enhanced by "centering," a technique practiced by many healers, for example, practitioners of Chinese, Tibetan, and Ayurvedic medicine. We explore the connections between centering, the cranial rhythmic impulse, and craniosacral treatment.

  3. Relationship between Hysterectomy and Admixture in African American Women

    PubMed Central

    Qi, Lihong; Nassir, Rami; Kosoy, Roman; Garcia, Lorena; Waetjen, L. Elaine; Ochs-Balcom, Heather M.; Gass, Margery; Robbins, John; Seldin, Michael F

    2013-01-01

    Objective Most studies suggest that hysterectomies are more common in African Americans than in other ethnic groups. To assess this ethnic surgical disparity in a novel way, our main goal was to determine whether admixture (the proportion of sub-Saharan African or European origin in individuals) is associated with hysterectomy frequency in African American women in the Women’s Health Initiative (WHI). Study Design In this retrospective study, we used ancestry informative single nucleotide polymorphisms (SNPs) to estimate admixture proportions in >10,000 African American women from the WHI. Logistic regression models were used to assess the association between admixture and self-reported history of hysterectomy with and without controlling for relevant covariates. Multinomial logistic regression models were used to assess the association between admixture and self-reported age of hysterectomy. We also considered other potential risk factors (adiposity, hypertension, and education) for hysterectomy accounting for admixture. Results African admixture was a strong risk factor after adjusting for multiple covariates (OR 1.85, P<.0001). The admixture risk for hysterectomy was highest for those performed in the 35–39 age range (OR 3.08, P<.0001) and least evident in oldest ages (45 or older). Our analyses also suggest that adiposity, hypertension and education were independently associated with hysterectomy in this population group. Conclusion These results suggest that higher African admixture is associated with higher frequencies of hysterectomy and that genetic studies specifically targeting African American women and diseases associated with hysterectomy may be especially useful in understanding the pathogenesis and underlying cause of this disparity in health outcome. PMID:23333549

  4. Indian Siddis: African descendants with Indian admixture.

    PubMed

    Shah, Anish M; Tamang, Rakesh; Moorjani, Priya; Rani, Deepa Selvi; Govindaraj, Periyasamy; Kulkarni, Gururaj; Bhattacharya, Tanmoy; Mustak, Mohammed S; Bhaskar, L V K S; Reddy, Alla G; Gadhvi, Dharmendra; Gai, Pramod B; Chaubey, Gyaneshwer; Patterson, Nick; Reich, David; Tyler-Smith, Chris; Singh, Lalji; Thangaraj, Kumarasamy

    2011-07-15

    The Siddis (Afro-Indians) are a tribal population whose members live in coastal Karnataka, Gujarat, and in some parts of Andhra Pradesh. Historical records indicate that the Portuguese brought the Siddis to India from Africa about 300-500 years ago; however, there is little information about their more precise ancestral origins. Here, we perform a genome-wide survey to understand the population history of the Siddis. Using hundreds of thousands of autosomal markers, we show that they have inherited ancestry from Africans, Indians, and possibly Europeans (Portuguese). Additionally, analyses of the uniparental (Y-chromosomal and mitochondrial DNA) markers indicate that the Siddis trace their ancestry to Bantu speakers from sub-Saharan Africa. We estimate that the admixture between the African ancestors of the Siddis and neighboring South Asian groups probably occurred in the past eight generations (∼200 years ago), consistent with historical records. Copyright © 2011 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  5. Polymorphic Admixture Typing in Human Ethnic Populations

    PubMed Central

    Dean, Michael; Stephens, J. Claiborne; Winkler, Cheryl; Lomb, Deborah A.; Ramsburg, Mark; Boaze, Raleigh; Stewart, Claudia; Charbonneau, Lauren; Goldman, David; Albaugh, Bernard J.; Goedert, James J.; Beasley, R. Palmer; Hwang, Lu-Yu; Buchbinder, Susan; Weedon, Michael; Johnson, Patricia A.; Eichelberger, Mary; O'Brien, Stephen J.

    1994-01-01

    A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome. Probes from each locus were used in a Southern blot survey of allele frequency distribution for four human ethnic groups: Caucasian, African American, Asian (Chinese), and American Indian (Cheyenne). Nearly all RFLP loci were polymorphic in each group, albeit with a broad range of differing allele frequencies (δ). The distribution of frequency differences (δ values) was used for three purposes: (1) to provide estimates for genetic distance (differentiation) among these ethnic groups, (2) to revisit with a large data set the proportion of human genetic variation attributable to differentiation within ethnic groups, and (3) to identify loci with high δ values between recently admixed populations of use in mapping by admixture linkage disequilibrium (MALD). Although most markers display significant allele frequency differences between ethnic groups, the overall genetic distances between ethnic groups were small (.066–.098), and <10% of the measured overall molecular genetic diversity in these human samples can be attributed to “racial” differentiation. The median δ values for pairwise comparisons between groups fell between .15 and .20, permitting identification of highly informative RFLP loci for MALD disease association studies. PMID:7942857

  6. Geographic patterns of genome admixture in Latin American Mestizos.

    PubMed

    Wang, Sijia; Ray, Nicolas; Rojas, Winston; Parra, Maria V; Bedoya, Gabriel; Gallo, Carla; Poletti, Giovanni; Mazzotti, Guido; Hill, Kim; Hurtado, Ana M; Camrena, Beatriz; Nicolini, Humberto; Klitz, William; Barrantes, Ramiro; Molina, Julio A; Freimer, Nelson B; Bortolini, Maria Cátira; Salzano, Francisco M; Petzl-Erler, Maria L; Tsuneto, Luiza T; Dipierri, José E; Alfaro, Emma L; Bailliet, Graciela; Bianchi, Nestor O; Llop, Elena; Rothhammer, Francisco; Excoffier, Laurent; Ruiz-Linares, Andrés

    2008-03-21

    The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.

  7. Geographic Patterns of Genome Admixture in Latin American Mestizos

    PubMed Central

    Wang, Sijia; Ray, Nicolas; Rojas, Winston; Parra, Maria V.; Bedoya, Gabriel; Gallo, Carla; Poletti, Giovanni; Hill, Kim; Hurtado, Ana M.; Camrena, Beatriz; Nicolini, Humberto; Klitz, William; Barrantes, Ramiro; Molina, Julio A.; Freimer, Nelson B.; Bortolini, Maria Cátira; Salzano, Francisco M.; Petzl-Erler, Maria L.; Tsuneto, Luiza T.; Dipierri, José E.; Alfaro, Emma L.; Bailliet, Graciela; Bianchi, Nestor O.; Llop, Elena; Rothhammer, Francisco; Excoffier, Laurent; Ruiz-Linares, Andrés

    2008-01-01

    The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. PMID:18369456

  8. Food entrainment: major and recent findings.

    PubMed

    Carneiro, Breno T S; Araujo, John F

    2012-01-01

    Mammals exhibit daily anticipatory activity to cycles of food availability. Studies on such food anticipatory activity (FAA) have been conducted mainly in nocturnal rodents. They have identified FAA as the behavioral output of a food entrained oscillator (FEO), separate of the known light entrained oscillator (LEO) located in the suprachiasmatic nucleus (SCN) of hypothalamus. Here we briefly review the main characteristics of FAA. Also, we present results on four topics of food anticipation: (1) possible input signals to FEO, (2) FEO substrate, (3) the importance of canonical clock genes for FAA, and (4) potential practical applications of scheduled feeding. This mini review is intended to introduce the subject of food entrainment to those unfamiliar with it but also present them with relevant new findings on the issue.

  9. Jet entrainment in pumped-storage reservoirs

    NASA Astrophysics Data System (ADS)

    Roberts, P. J. W.

    1981-03-01

    A literature review was made in order to recommend a mathematical model to predict jet entrainment in pumped-storage reservoirs. It was found that because of the many different types of inflow situations possible, no one mathematical model would be adequate in all cases. It is recommended that each flow situation be classified and entrainment be predicted for each situation by means of techniques presented in the report. The flows are classified according to the source geometry, source buoyancy, ambient stratification, and degree of submergence. A primary and secondary classification scheme resulted in 16 possible flow types. Each situation is reviewed separately and a method for predicting entrainment presented. To use the results, judgment must first be used to classify the flow under consideration and the appropriate technique for that class of flows used. If some of the flows discussed are prevalent or of particular interest, they could be investigated in more depth and mathematical models of those developed.

  10. Observational estimates of detrainment and entrainment in non-precipitating shallow cumulus

    NASA Astrophysics Data System (ADS)

    Norgren, M. S.; Small, J. D.; Jonsson, H. H.; Chuang, P. Y.

    2016-01-01

    Vertical transport associated with cumulus clouds is important to the redistribution of gases, particles, and energy, with subsequent consequences for many aspects of the climate system. Previous studies have suggested that detrainment from clouds can be comparable to the updraft mass flux, and thus represents an important contribution to vertical transport. In this study, we describe a new method to deduce the amounts of gross detrainment and entrainment experienced by non-precipitating cumulus clouds using aircraft observations. The method utilizes equations for three conserved variables: cloud mass, total water, and moist static energy. Optimizing these three equations leads to estimates of the mass fractions of adiabatic mixed-layer air, entrained air and detrained air that the sampled cloud has experienced. The method is applied to six flights of the CIRPAS Twin Otter during the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) which took place in the Houston, Texas region during the summer of 2006 during which 176 small, non-precipitating cumuli were sampled. Using our novel method, we find that, on average, these clouds were comprised of 30 to 70 % mixed-layer air, with entrained air comprising most of the remainder. The mass fraction of detrained air was usually very small, less than 2 %, although values larger than 10 % were found in 15 % of clouds. Entrained and detrained air mass fractions both increased with altitude, consistent with some previous observational studies. The largest detrainment events were almost all associated with air that was at their level of neutral buoyancy, which has been hypothesized in previous modeling studies. This new method could be readily used with data from other previous aircraft campaigns to expand our understanding of detrainment for a variety of cloud systems.

  11. Ozone conservation and entrainment in cumulus congestus

    NASA Technical Reports Server (NTRS)

    Pearson, R., Jr.; Weaver, C. J.

    1989-01-01

    This study demonstrates that ozone mixing ratio is conserved during moist convection and can be used as a tracer for cloud entrainment studies. The approach is to apply mixing line analysis to pairs of liquid water potential temperature, total water mixing ratio, O3 and pseudo-equivalent potential temperature derived from aircraft penetrations of growing cumulus congestus. Conclusions about entrainment from the mixing diagrams employing O3 agree with those using thermodynamic quantities. Any disagreement uncovered deficiencies in the water substance measurement technique.

  12. The Admixture Structure and Genetic Variation of the Archipelago of Cape Verde and Its Implications for Admixture Mapping Studies

    PubMed Central

    Beleza, Sandra; Campos, Joana; Lopes, Jailson; Araújo, Isabel Inês; Hoppfer Almada, Ana; e Silva, António Correia; Parra, Esteban J.; Rocha, Jorge

    2012-01-01

    Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde islands in West Africa are highly admixed and primarily descended from European males and African females. However, little is known about the variation in admixture levels, admixture dynamics and genetic diversity across the islands, or about the potential of Cape Verde for admixture mapping studies. We have performed a detailed analysis of phenotypic and genetic variation in Cape Verde based on objective skin color measurements, socio-economic status (SES) evaluations and data for 50 autosomal, 34 X-chromosome, and 21 non-recombinant Y-chromosome (NRY) markers in 845 individuals from six islands of the archipelago. We find extensive genetic admixture between European and African ancestral populations (mean West African ancestry = 0.57, sd = 0.08), with individual African ancestry proportions varying considerably among the islands. African ancestry proportions calculated with X and Y-chromosome markers confirm that the pattern of admixture has been sex-biased. The high-resolution NRY-STRs reveal additional patterns of variation among the islands that are most consistent with differentiation after admixture. The differences in the autosomal admixture proportions are clearly evident in the skin color distribution across the islands (Pearson r = 0.54, P-value<2e–16). Despite this strong correlation, there are significant interactions between SES and skin color that are independent of the relationship between skin color and genetic ancestry. The observed distributions of admixture, genetic variation and skin color and the relationship of skin color with SES relate to historical and social events taking place during the settlement history of Cape Verde, and have

  13. The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies.

    PubMed

    Beleza, Sandra; Campos, Joana; Lopes, Jailson; Araújo, Isabel Inês; Hoppfer Almada, Ana; Correia e Silva, António; Parra, Esteban J; Rocha, Jorge

    2012-01-01

    Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde islands in West Africa are highly admixed and primarily descended from European males and African females. However, little is known about the variation in admixture levels, admixture dynamics and genetic diversity across the islands, or about the potential of Cape Verde for admixture mapping studies. We have performed a detailed analysis of phenotypic and genetic variation in Cape Verde based on objective skin color measurements, socio-economic status (SES) evaluations and data for 50 autosomal, 34 X-chromosome, and 21 non-recombinant Y-chromosome (NRY) markers in 845 individuals from six islands of the archipelago. We find extensive genetic admixture between European and African ancestral populations (mean West African ancestry = 0.57, sd = 0.08), with individual African ancestry proportions varying considerably among the islands. African ancestry proportions calculated with X and Y-chromosome markers confirm that the pattern of admixture has been sex-biased. The high-resolution NRY-STRs reveal additional patterns of variation among the islands that are most consistent with differentiation after admixture. The differences in the autosomal admixture proportions are clearly evident in the skin color distribution across the islands (Pearson r = 0.54, P-value<2e-16). Despite this strong correlation, there are significant interactions between SES and skin color that are independent of the relationship between skin color and genetic ancestry. The observed distributions of admixture, genetic variation and skin color and the relationship of skin color with SES relate to historical and social events taking place during the settlement history of Cape Verde, and have implications for

  14. Entrainment rate of droplets in the ripple-annular regime for small vertical tubes

    SciTech Connect

    Lopez de Bertodano, M.A.; Assad, A.; Beus, S.G.

    1998-06-01

    Two-fluid model predictions of film dryout in annular flow are limited by the uncertainties in the constitutive relations for the entrainment rate of droplets from the liquid film. The main cause of these uncertainties is the lack of separate effects experimental data in the range of the operating conditions in nuclear power reactors. Air/water and Freon-113 entrainment rate data have been obtained in 10 mm tubes using the film extraction technique. These experiments have been scaled to approach high pressure steam-water flow conditions. The effects of surface tension and density ratio, missing from most previous data sets, have been systematically tested. The entrainment rate mechanism is assumed to be a Kelvin-Helmholtz instability. Based on this analysis and two previous correlations, a new correlation is proposed that is valid for low viscosity fluids in small ducts in the ripple annular regime.

  15. Study on Droplet Entrainment of High-Viscosity Falling Liquid Film

    NASA Astrophysics Data System (ADS)

    Inumaru, Jun; Ohtaka, Maromu; Watanabe, Hiroaki

    An experimental study of counter-current annular two-phase flow of high-viscosity liquid and air in a large diameter pipe was carried out to investigate the inception criterion for entrainment of molten slag droplet in an entrained flow coal gasifier. Liquid film thickness was measured using a high-speed camera for 4 types of liquid with various viscosities and surface tensions. It was clearly shown that the measured average wave amplitude had a good correlation with the gas Reynolds number, and that the predicted critical gas velocity for droplet inception using new formula of wave amplitude had a good agreement with the experimental results under the condition of very low fluid Reynolds number( Ref ≤10). The critical Weber number Wec =1.73 was obtained as inception criterion of droplet entrainment.

  16. Entrainment measurements in annular flow

    SciTech Connect

    Assad, A.; Jan, C.; Bertodano, M. de; Beus, S.G.

    1997-07-01

    Air/water and vapor/freon were utilized to scale and simulate annular two-phase flow for high pressure steam/water conditions. A unique vapor/liquid Freon loop was built to obtain the high pressure data. The results were compared with two correlations available in the open literature. The Ishii and Mishima dimensionless group was able to scale the data remarkably well even for vapor/liquid Freon. However, the correlation needs to be adjusted for high Weber numbers of the gas phase.

  17. Inclined gravity currents filling basins: The influence of Reynolds number on entrainment into gravity currents

    NASA Astrophysics Data System (ADS)

    Hogg, Charlie A. R.; Dalziel, Stuart B.; Huppert, Herbert E.; Imberger, Jörg

    2015-09-01

    In many important natural and industrial systems, gravity currents of dense fluid feed basins. Examples include lakes fed by dense rivers and auditoria supplied with cooled air by ventilation systems. As we will show, the entrainment into such buoyancy driven currents can be influenced by viscous forces. Little work, however, has examined this viscous influence and how entrainment varies with the Reynolds number, Re. Using the idea of an entrainment coefficient, E, we derive a mathematical expression for the rise of the front at the top of the dense fluid ponding in a basin, where the horizontal cross-sectional area of the basin varies linearly with depth. We compare this expression to experiments on gravity currents with source Reynolds numbers, Res, covering the broad range 100 < Res < 1500. The form of the observed frontal rises was well approximated by our theory. By fitting the observed frontal rises to the theoretical form with E as the free parameter, we find a linear trend for E(Res) over the range 350 < Res < 1100, which is in the transition to turbulent flow. In the experiments, the entrainment coefficient, E, varied from 4 × 10-5 to 7 × 10-2. These observations show that viscous damping can be a dominant influence on gravity current entrainment in the laboratory and in geophysical flows in this transitional regime.

  18. Impact of reduced near-field entrainment of overpressured volcanic jets on plume development

    USGS Publications Warehouse

    Saffaraval, Farhad; Solovitz, Stephen A.; Ogden, Darcy E.; Mastin, Larry G.

    2012-01-01

    Volcanic plumes are often studied using one-dimensional analytical models, which use an empirical entrainment ratio to close the equations. Although this ratio is typically treated as constant, its value near the vent is significantly reduced due to flow development and overpressured conditions. To improve the accuracy of these models, a series of experiments was performed using particle image velocimetry, a high-accuracy, full-field velocity measurement technique. Experiments considered a high-speed jet with Reynolds numbers up to 467,000 and exit pressures up to 2.93 times atmospheric. Exit gas densities were also varied from 0.18 to 1.4 times that of air. The measured velocity was integrated to determine entrainment directly. For jets with exit pressures near atmospheric, entrainment was approximately 30% less than the fully developed level at 20 diameters from the exit. At pressures nearly three times that of the atmosphere, entrainment was 60% less. These results were introduced into Plumeria, a one-dimensional plume model, to examine the impact of reduced entrainment. The maximum column height was only slightly modified, but the critical radius for collapse was significantly reduced, decreasing by nearly a factor of two at moderate eruptive pressures.

  19. Liquid Droplet Detachment and Entrainment in Microscale Flows

    NASA Astrophysics Data System (ADS)

    Hidrovo, Carlos

    2005-11-01

    In this talk we will present a first order study of liquid water detachment and entrainment into air flows in hydrophobic microchannels. Silicon based microstructures consisting of 23 mm long U-shaped channels of different geometry were used for this purpose. The structures are treated with a Molecular Vapor Deposition (MVD) process that renders them hydrophobic. Liquid water is injected through a side slot located 2/3 of the way downstream from the air channel inlet. The water entering the air channel beads up into slugs or droplets that grow in size at this injection location until they fill and flood the channel or are carried away by the air flow. The slugs/droplets dimensions at detachment are correlated against superficial gas velocity and proper dimensionless parameters are postulated and examined to compare hydrodynamic forces against surface tension. It is found that slug/droplet detachment is dominated by two main forces: pressure gradient drag, arising from confinement of a viscous flow in the channel, and inertial drag, arising from the stagnation of the air due to obstruction by the slugs/droplets. A detachment regime map is postulated based on the relative importance of these forces under different flow conditions.

  20. Methods for High-Density Admixture Mapping of Disease Genes

    PubMed Central

    Patterson, Nick; Hattangadi, Neil; Lane, Barton; Lohmueller, Kirk E.; Hafler, David A.; Oksenberg, Jorge R.; Hauser, Stephen L.; Smith, Michael W.; O’Brien, Stephen J.; Altshuler, David; Daly, Mark J.; Reich, David

    2004-01-01

    Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) has been proposed as an efficient approach to localizing disease-causing variants that differ in frequency (because of either drift or selection) between two historically separated populations. Near a disease gene, patient populations descended from the recent mixing of two or more ethnic groups should have an increased probability of inheriting the alleles derived from the ethnic group that carries more disease-susceptibility alleles. The central attraction of admixture mapping is that, since gene flow has occurred recently in modern populations (e.g., in African and Hispanic Americans in the past 20 generations), it is expected that admixture-generated linkage disequilibrium should extend for many centimorgans. High-resolution marker sets are now becoming available to test this approach, but progress will require (a) computational methods to infer ancestral origin at each point in the genome and (b) empirical characterization of the general properties of linkage disequilibrium due to admixture. Here we describe statistical methods to estimate the ancestral origin of a locus on the basis of the composite genotypes of linked markers, and we show that this approach accurately estimates states of ancestral origin along the genome. We apply this approach to show that strong admixture linkage disequilibrium extends, on average, for 17 cM in African Americans. Finally, we present power calculations under varying models of disease risk, sample size, and proportions of ancestry. Studying ∼2,500 markers in ∼2,500 patients should provide power to detect many regions contributing to common disease. A particularly important result is that the power of an admixture mapping study to detect a locus will be nearly the same for a wide range of mixture scenarios: the mixture proportion should be 10%–90% from both ancestral populations. PMID:15088269

  1. Attentional entrainment and perceived event duration

    PubMed Central

    McAuley, J. Devin; Fromboluti, Elisa Kim

    2014-01-01

    This study considered the contribution of dynamic attending theory (DAT) and attentional entrainment to systematic distortions in perceived event duration. Three experiments were conducted using an auditory oddball paradigm, in which listeners judged the duration of a deviant (oddball) stimulus embedded within a series of identical (standard) stimuli. To test for a role of attentional entrainment in perceived oddball duration, oddballs were presented at either temporally expected (on time) or unexpectedly early or late time points relative to extrapolation of the context rhythm. Consistent with involvement of attentional entrainment in perceived duration, duration judgements about the oddball were least distorted when the oddball occurred on time with respect to the entrained rhythm, whereas durations of early and late oddballs were perceived to be shorter and longer, respectively. This pattern of results was independent of the absolute time interval preceding the oddball. Moreover, as expected, an irregularly timed sequence context weakened observed differences between oddballs with on-time and late onsets. Combined with other recent work on the role of temporal preparation in duration distortions, the present findings allot at least a portion of the oddball effect to increased attention to events that are more expected, rather than on their unexpected nature per se. PMID:25385779

  2. Washing of the AW-101 entrained solids

    SciTech Connect

    GJ Lumetta

    2000-03-31

    BNFL Inc. (BNFL) is under contract with the US Department of Energy, River Protection Project (DOE-RPP) to design, construct, and operate facilities for treating wastes stored in the single-shell and double-shell tanks at the Hanford Site, Richland, Washington. The DOE-BNFL RPP contract identifies two feeds to the waste treatment plant: (1) primarily liquid low-activity waste (LAW) consisting of less than 2 wt% entrained solids and (2) high-level waste (HLW) consisting of 10 to 200 g/L solids slurry. This report describes the results of a test conducted by Battelle to assess the effects of inhibited water washing on the composition of the entrained solids in the diluted AW-101 low-activity waste (LAW) sample. The objective of this work was to gather data on the solubility of the AW-101 entrained solids in 0.01 M NaOH, so that BNFL can evaluate whether these solids require caustic leaching. The work was conducted according to test plan BNFL-TP-29953-9, Rev. 0, LAW Entrained Solids Water Wash and Caustic Leach Testing. The test went according to plan, with no deviations from the test plan. Based on the results of the 0.01 M NaOH washing, a decision was made by BNFL to not proceed with the caustic leaching test. The composition of the washed solids was such that caustic leaching would not result in significant reduction in the immobilized HLW volume.

  3. Drugs of abuse can entrain circadian rhythms.

    PubMed

    Kosobud, Ann E K; Gillman, Andrea G; Leffel, Joseph K; Pecoraro, Norman C; Rebec, G V; Timberlake, William

    2007-11-02

    Circadian rhythms prepare organisms for predictable events in the 24 h day. These rhythms are entrained by a variety of stimuli. Light is the most ubiquitous and best known zeitgeber, but a number of others have been identified, including food, social cues, locomotor activity, and, most recently drugs of abuse. Given the diversity of zeitgebers, it is probably not surprising that genes capable of clock functions are located throughout almost all organs and tissues. Recent evidence suggests that drugs of abuse can directly entrain some circadian rhythms. We have report here that entrainment by drugs of abuse is independent of the suprachiasmatic nucleus and the light/dark cycle, is not dependent on direct locomotor stimulation, and is shared by a variety of classes of drugs of abuse. We suggest that drug-entrained rhythms reflect variations in underlying neurophysiological states. This could be the basis for known daily variations in drug metabolism, tolerance, and sensitivity to drug reward. These rhythms could also take the form of daily periods of increased motivation to seek and take drugs, and thus contribute to abuse, addiction and relapse.

  4. Calvert Cliffs zooplankton entrainment study. Final report

    SciTech Connect

    Bradley, B.P.

    1980-01-01

    Entrainment studies to evaluate plant effects on zooplankton were conducted at the Calvert Cliffs Nuclear Plant. Specific effects tested were (a) the spatial and temporal variation of zooplankton density; (b) pump sampling efficiency; (c) delayed mortality; (d) vital staining as an indicator of mortality.

  5. Laminar Entrained Flow Reactor (Fact Sheet)

    SciTech Connect

    None, None

    2014-02-01

    The Laminar Entrained Flow Reactor (LEFR) is a modular, lab scale, single-user reactor for the study of catalytic fast pyrolysis (CFP). This system can be employed to study a variety of reactor conditions for both in situ and ex situ CFP.

  6. Plume rise, entrainment and dispersion in turbulent winds

    NASA Astrophysics Data System (ADS)

    Netterville, Dennett D. J.

    This paper describes a new analytical model which combines within one theoretical framework several aspects of the phenomena of plume rise, dispersion, thermal stratification and ambient turbulence. The model is based in part on knowledge gained from recent investigations of flow within free shear layers. The observations suggest a simple model for the turbulent mixing process, which accounts for the known entrainment of air into smoke plumes by plume-generated turbulence. More importantly, the model also predicts a path by which ambient turbulence causes reverse entrainment of plume material into the surrounding fluids. This gives rise to a new 'extrainment' term in each of the plume momentum and buoyancy equations. These equations are solved for a turbulent atmosphere of arbitrary thermal stability, and yield plume trajectories which gradually level off at final rise heights that depend on the degree of thermal stratification and on the scale and intensity of ambient turbulence. A link between plume rise and dispersion is identified by means of the concentration species equation, which is solved to show that the plume acts along its length as a distributed source of passively dispersing material. The new theory, specialized for an adiabatic atmosphere, plus the familiar x2/3 law and a semi-empirical final rise theory from the literature, are all compared against full-scale data on plume rise in turbulent winds. The new theory significantly improves the accuracy of estimates of plume trajectory and final plume height. The price for this improved predictive ability is the need to evaluate the air temperature and its gradient at plume level, and the corresponding intensity and scale of turbulent air movement. This is no longer a technical obstacle since recently developed SODAR and RASS remote sensors have this capability.

  7. Cloud top entrainment instability and cloud top distributions

    NASA Technical Reports Server (NTRS)

    Boers, Reinout; Spinhirne, James D.

    1990-01-01

    Classical cloud-top entrainment instability condition formulation is discussed. A saturation point diagram is used to investigate the details of mixing in cases where the cloud-top entrainment instability criterion is satisfied.

  8. Mass Entrainment Rate of an Ideal Momentum Turbulent Round Jet

    NASA Astrophysics Data System (ADS)

    Medrano, Fermín Franco; Fukumoto, Yasuhide; Marika Velte, Clara; Hodžić, Azur

    2017-03-01

    We propose a two-phase-fluid model for a full-cone turbulent round jet that describes its dynamics in a simple but comprehensive manner with only the apex angle of the cone being a disposable parameter. The basic assumptions are that (i) the jet is statistically stationary and that (ii) it can be approximated by a mixture of two fluids with their phases in dynamic equilibrium. To derive the model, we impose conservation of the initial volume and total momentum fluxes. Our model equations admit analytical solutions for the composite density and velocity of the two-phase fluid, both as functions of the distance from the nozzle, from which the dynamic pressure and the mass entrainment rate are calculated. Assuming a far-field approximation, we theoretically derive a constant entrainment rate coefficient solely in terms of the cone angle. Moreover, we carry out experiments for a single-phase turbulent air jet and show that the predictions of our model compare well with this and other experimental data of atomizing liquid jets.

  9. Parameterizing Convective Organization to Escape the Entrainment Dilemma

    NASA Astrophysics Data System (ADS)

    Mapes, Brian; Neale, Richard

    2011-06-01

    Lateral mixing parameters in buoyancy-driven deep convection schemes are among the most sensitive and important unknowns in atmosphere models. Unfortunately, there is not a true optimum value for plume mixing rate, but rather a dilemma or tradeoff: Excessive dilution of updrafts leads to unstable stratification bias in the mean state, while inadequate dilution allows deep convection to occur too easily, causing poor space and time distributions and variability. In this too-small parameter space, compromises are made based on competing metrics of model performance. We attempt to escape this “entrainment dilemma” by making bulk plume parameters (chiefly entrainment rate) depend on a new prognostic variable (“organization,” org) meant to reflect the rectified effects of subgrid-scale structure in meteorological fields. We test an org scheme in the Community Atmosphere Model (CAM5) with a new unified shallow-deep convection scheme (UW-ens, a 2-plume version of the University of Washington scheme). Since buoyant ascent involves natural selection, subgrid structure makes convection systematically deeper and stronger than the pure unorganized case: plumes of average (or randomly sampled) air rising in the average environment. To reflect this, org is nonnegative, but we leave it dimensionless. A time scale characterizes its behavior (here ˜3 h for a 2o model). Currently its source is rain evaporation, but other sources can be added easily. We also let org be horizontally transported by advection, as a mass-weighted mean over the convecting layer. Linear coefficients link org to a plume ensemble, which it assists via: 1) plume base warmth above the mean temperature 2) plume radius enhancement (reduced mixing), and 3) increased probability of overlap in a multi-plume scheme, where interactions benefit later generations (this part has only been implemented in an offline toy column model). Since rain evaporation is a source for org, it functions as a time-lagged but

  10. Speech Entrainment Compensates for Broca's Area Damage

    PubMed Central

    Fridriksson, Julius; Basilakos, Alexandra; Hickok, Gregory; Bonilha, Leonardo; Rorden, Chris

    2015-01-01

    Speech entrainment (SE), the online mimicking of an audiovisual speech model, has been shown to increase speech fluency in patients with Broca's aphasia. However, not all individuals with aphasia benefit from SE. The purpose of this study was to identify patterns of cortical damage that predict a positive response SE's fluency-inducing effects. Forty-four chronic patients with left hemisphere stroke (15 female) were included in this study. Participants completed two tasks: 1) spontaneous speech production, and 2) audiovisual SE. Number of different words per minute was calculated as a speech output measure for each task, with the difference between SE and spontaneous speech conditions yielding a measure of fluency improvement. Voxel-wise lesion-symptom mapping (VLSM) was used to relate the number of different words per minute for spontaneous speech, SE, and SE-related improvement to patterns of brain damage in order to predict lesion locations associated with the fluency-inducing response to speech entrainment. Individuals with Broca's aphasia demonstrated a significant increase in different words per minute during speech entrainment versus spontaneous speech. A similar pattern of improvement was not seen in patients with other types of aphasia. VLSM analysis revealed damage to the inferior frontal gyrus predicted this response. Results suggest that SE exerts its fluency-inducing effects by providing a surrogate target for speech production via internal monitoring processes. Clinically, these results add further support for the use of speech entrainment to improve speech production and may help select patients for speech entrainment treatment. PMID:25989443

  11. Effectiveness of mineral admixtures in reducing ASR expansion

    SciTech Connect

    Xu, G.J.Z.; Watt, D.F.; Hudec, P.P.

    1995-08-01

    This paper investigates the effectiveness of eight mineral admixtures in reducing the alkali silica(te) reactivity of cement mortar. The admixtures include one class F fly ash, a condensed silica fume, a ground fiberglass, three glass containing waste materials, and two inert fillers (carbon and calcium carbonate). Mortar bar expansion, the change in evaporable water content, the evidence of reaction and the composition of reaction products were studied. It was found that shale is the only reactive component of the sand and the effectiveness of admixtures in reducing alkali-silica reaction depends largely on the chemical composition of the admixtures. Ground fiberglass is very effective in controlling the alkali silica reaction, while inert fillers have only a dilution effect. It is thought that admixtures reduce ASR expansion by two reactions: (1) pozzolanic reaction that reduces the permeability of concrete and entraps some fraction of the alkali ions; (2) alkali silica reaction that consumes most of the available alkali ions and thereby prevents the reaction between alkalis and aggregate.

  12. Testing for Ancient Admixture between Closely Related Populations

    PubMed Central

    Durand, Eric Y.; Patterson, Nick; Reich, David; Slatkin, Montgomery

    2011-01-01

    One enduring question in evolutionary biology is the extent of archaic admixture in the genomes of present-day populations. In this paper, we present a test for ancient admixture that exploits the asymmetry in the frequencies of the two nonconcordant gene trees in a three-population tree. This test was first applied to detect interbreeding between Neandertals and modern humans. We derive the analytic expectation of a test statistic, called the D statistic, which is sensitive to asymmetry under alternative demographic scenarios. We show that the D statistic is insensitive to some demographic assumptions such as ancestral population sizes and requires only the assumption that the ancestral populations were randomly mating. An important aspect of D statistics is that they can be used to detect archaic admixture even when no archaic sample is available. We explore the effect of sequencing error on the false-positive rate of the test for admixture, and we show how to estimate the proportion of archaic ancestry in the genomes of present-day populations. We also investigate a model of subdivision in ancestral populations that can result in D statistics that indicate recent admixture. PMID:21325092

  13. Maximum-likelihood estimation of admixture proportions from genetic data.

    PubMed Central

    Wang, Jinliang

    2003-01-01

    For an admixed population, an important question is how much genetic contribution comes from each parental population. Several methods have been developed to estimate such admixture proportions, using data on genetic markers sampled from parental and admixed populations. In this study, I propose a likelihood method to estimate jointly the admixture proportions, the genetic drift that occurred to the admixed population and each parental population during the period between the hybridization and sampling events, and the genetic drift in each ancestral population within the interval between their split and hybridization. The results from extensive simulations using various combinations of relevant parameter values show that in general much more accurate and precise estimates of admixture proportions are obtained from the likelihood method than from previous methods. The likelihood method also yields reasonable estimates of genetic drift that occurred to each population, which translate into relative effective sizes (N(e)) or absolute average N(e)'s if the times when the relevant events (such as population split, admixture, and sampling) occurred are known. The proposed likelihood method also has features such as relatively low computational requirement compared with previous ones, flexibility for admixture models, and marker types. In particular, it allows for missing data from a contributing parental population. The method is applied to a human data set and a wolflike canids data set, and the results obtained are discussed in comparison with those from other estimators and from previous studies. PMID:12807794

  14. Admixture in Hispanic-Americans: Its impact on ITGAM association and implications for admixture mapping in SLE

    PubMed Central

    Molineros, Julio E.; Kim-Howard, Xana; Deshmukh, Harshal; Jacob, Chaim O.; Harley, John B.; Nath, Swapan K.

    2009-01-01

    Systemic Lupus Erythematosus (SLE) disproportionately affects minorities, such as Hispanic-Americans. Prevalence of SLE is 3–5 times higher in Hispanic Americans (HA) than European derived populations, and have more active disease at the time of diagnosis, with more serious organ system involvement. HA is an admixed population, it is possible that there is an effect of admixture on the relative risk of disease. This admixture can create substantial increase of linkage disequilibrium (LD) in both magnitude and range, which can provide a unique opportunity for admixture mapping. Main objectives of this study are to (a) estimate hidden population structure in HA individuals; (b) estimate individual ancestry proportions and its impact on SLE risk; (c) assess impact of admixture on ITGAM association, a recently identified SLE susceptibility gene; and (d) estimate power of admixture mapping in HA. Our dataset contained 1,125 individuals, of whom 884 (657 SLE cases and 227 controls) were self classified as HA. Using 107 unlinked ancestry informative markers (AIMs) we estimated hidden population structure and individual ancestry in HA. Out of 5,671 possible pair-wise LD, 54% were statistically significant, indicating recent population admixture. The best fitted model for HA was a four population model with average ancestry of European (48%), American-Indian (40%), African (8%) and a fourth population (4%) with unknown ancestry. We also identified significant higher risk associated with American-Indian ancestry (OR=4.84, P=0.0001, 95%CI=2.14—10.95) on overall SLE. We showed that ITGAM is associated as a risk factor for SLE (OR= 2.06, P=8.74×10−5, 95%CI=1.44–2.97). This association is not affected by population substructure or admixture. We have demonstrated that HA have great potential and are an 3 appropriate population for admixture mapping. As expected, the case-only design is more powerful than case-control design, for any given admixture proportion or ancestry

  15. The dynamic effects of moisture on the entrainment and transport of sand by wind

    NASA Astrophysics Data System (ADS)

    Wiggs, G. F. S.; Baird, A. J.; Atherton, R. J.

    2004-04-01

    There is an increasing awareness of the influence of surface moisture on aeolian entrainment and transport of sediment. Existing wind tunnel studies have shown the impact of a limited range of moisture contents on entrainment thresholds but similar investigations are lacking in the field. The research reported here investigated the influence of changes in surface moisture content on sand entrainment and transport on a meso-tidal beach in Anglesey, North Wales. High frequency (1 Hz) wind velocities measured with hot-wire anemometers were combined with grain impact data from a Sensit monitor and mass flux measurements from a standard sand trap. Surface and near-surface moisture contents were assessed gravimetrically from surface sand scrapes and also directly by using a ThetaProbe. Critical threshold values for entrainment were specified using a modified form of the time fraction equivalence method (Stout, J.E., Zobeck, T.M., 1996a. Establishing the threshold condition for soil movement in wind-eroding fields. Proceedings of the International Conference on Air Pollution from Agricultural Operations. MWPS C-3, Kansas City, 7-9 February 1996, pp. 65-71). Results indicate a time-dependent change in dominant control of the sand transport system from moisture to wind speed, dependent upon the moisture content of the surface sediment. This interchange between controlling parameters on both entrainment and transport was very sensitive to prevailing moisture conditions and took place over a period of minutes to hours. Under conditions experienced in the experiments presented here, the critical moisture threshold for sediment entrainment was determined to be between 4% and 6%, higher than the 1-4% specified in previous wind tunnel experiments. Furthermore, a moisture content of nearly 2% (where moisture was adhered to transported sediment) appeared to have little or no impact on the rate of sand flux.

  16. Impacts of winds on volcanic plumes - Do crossflows challenge the Morton, Turner and Taylor entrainment assumptions?

    NASA Astrophysics Data System (ADS)

    Aubry, T. J.; Jellinek, M.; Carazzo, G.

    2014-12-01

    Volcanic plumes rising into Earth's atmosphere are influenced strongly by tropospheric and stratospheric winds. In the absence of wind effects, Morton, Taylor and Turner (MTT, 1956) used a similarity theory to show that the maximum height for these flows is governed mostly by the atmospheric stratification and the buoyancy flux at the vent. Crucially, in developing this theory MTT introduced the "entrainment hypothesis" in which the rate of entrainment of atmospheric air by the large eddies forming at the edge of the plume is proportional to some bulk velocity. In the presence of wind a key question is whether the additional stirring deforms eddies sufficiently to alter their mixing properties. In particular, under what conditions will wind effects enhance or reduce entrainment? Can these effects be captured in a modified form of the MTT similarity theory or is a new theory required? We use an extensive set of experiments on wind-forced turbulent plumes in order to overcome the restricted dynamical conditions explored in previous experimental studies. We introduce a new regime parameter allowing to quantitatively separate three distinct plume regimes. Remarkably, we show that for reasonable conditions on Earth, the major effects of wind can still be captured by a modified scaling law derived from the self-similar theory of MTT, with an entrainment rate including the contributions of wind. However, analysis of the turbulence motions in our experiments shows that even weak winds introduce large asymmetries in the structure of entraining eddies. Our successful application of a mean entrainment rate at the plume edge and a modified MTT similarity theory is, thus, surprising. Does this apparent contradiction simply reveal the way turbulent instabilities driven by wind manifest themselves?

  17. Risk for rheumatic disease in relation to ethnicity and admixture

    PubMed Central

    Molokhia, Mariam; McKeigue, Paul

    2000-01-01

    Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans compared with Europeans. These differences are not accounted for by differences in allele or haplotype frequencies in the human leucocyte antigen (HLA) region or any other loci known to influence risk of rheumatic disease. Where there has been admixture between two or more ethnic groups that differ in risk of disease, studies of the relationship of disease risk to proportionate admixture can help to distinguish between genetic and environmental explanations for ethnic differences in disease risk and to map the genes underlying these differences. PMID:11094421

  18. AW-101 entrained solids - Solubility versus temperature

    SciTech Connect

    GJ Lumetta; RC Lettau; GF Piepel

    2000-03-31

    This report describes the results of a test conducted by Battelle to assess the solubility of the solids entrained in the diluted AW-101 low-activity waste (LAW) sample. BNFL requested Battelle to dilute the AW-1-1 sample using de-ionized water to mimic expected plant operating conditions. BNFL further requested Battelle to assess the solubility of the solids present in the diluted AW-101 sample versus temperature conditions of 30, 40, and 50 C. BNFL requested these tests to assess the composition of the LAW supernatant and solids versus expected plant-operating conditions. The work was conducted according to test plan BNFL-TP-29953-7, Rev. 0, Determination of the Solubility of LAW Entrained Solids. The test went according to plan, with no deviations from the test plan.

  19. Auditory-motor entrainment in vocal mimicking species

    PubMed Central

    2010-01-01

    We have recently found robust evidence of motor entrainment to auditory stimuli in multiple species of non-human animal, all of which were capable of vocal mimicry. In contrast, the ability remained markedly absent in many closely related species incapable of vocal mimicry. This suggests that vocal mimicry may be a necessary precondition for entrainment. However, within the vocal mimicking species, entrainment appeared non-randomly, suggesting that other components besides vocal mimicry play a role in the capacity and tendency to entrain. Here we discuss potential additional factors involved in entrainment. New survey data show that both male and female parrots are able to entrain, and that the entrainment capacity appears throughout the lifespan. We suggest routes for future study of entrainment, including both developmental studies in species known to entrain and further work to detect entrainment in species not well represented in our dataset. These studies may shed light on additional factors necessary for entrainment in addition to vocal mimicry. PMID:20714417

  20. Exploring Entrainment Patterns of Human Emotion in Social Media

    PubMed Central

    Luo, Chuan; Zhang, Zhu

    2016-01-01

    Emotion entrainment, which is generally defined as the synchronous convergence of human emotions, performs many important social functions. However, what the specific mechanisms of emotion entrainment are beyond in-person interactions, and how human emotions evolve under different entrainment patterns in large-scale social communities, are still unknown. In this paper, we aim to examine the massive emotion entrainment patterns and understand the underlying mechanisms in the context of social media. As modeling emotion dynamics on a large scale is often challenging, we elaborate a pragmatic framework to characterize and quantify the entrainment phenomenon. By applying this framework on the datasets from two large-scale social media platforms, we find that the emotions of online users entrain through social networks. We further uncover that online users often form their relations via dual entrainment, while maintain it through single entrainment. Remarkably, the emotions of online users are more convergent in nonreciprocal entrainment. Building on these findings, we develop an entrainment augmented model for emotion prediction. Experimental results suggest that entrainment patterns inform emotion proximity in dyads, and encoding their associations promotes emotion prediction. This work can further help us to understand the underlying dynamic process of large-scale online interactions and make more reasonable decisions regarding emergency situations, epidemic diseases, and political campaigns in cyberspace. PMID:26953692

  1. Exploring Entrainment Patterns of Human Emotion in Social Media.

    PubMed

    He, Saike; Zheng, Xiaolong; Zeng, Daniel; Luo, Chuan; Zhang, Zhu

    2016-01-01

    Emotion entrainment, which is generally defined as the synchronous convergence of human emotions, performs many important social functions. However, what the specific mechanisms of emotion entrainment are beyond in-person interactions, and how human emotions evolve under different entrainment patterns in large-scale social communities, are still unknown. In this paper, we aim to examine the massive emotion entrainment patterns and understand the underlying mechanisms in the context of social media. As modeling emotion dynamics on a large scale is often challenging, we elaborate a pragmatic framework to characterize and quantify the entrainment phenomenon. By applying this framework on the datasets from two large-scale social media platforms, we find that the emotions of online users entrain through social networks. We further uncover that online users often form their relations via dual entrainment, while maintain it through single entrainment. Remarkably, the emotions of online users are more convergent in nonreciprocal entrainment. Building on these findings, we develop an entrainment augmented model for emotion prediction. Experimental results suggest that entrainment patterns inform emotion proximity in dyads, and encoding their associations promotes emotion prediction. This work can further help us to understand the underlying dynamic process of large-scale online interactions and make more reasonable decisions regarding emergency situations, epidemic diseases, and political campaigns in cyberspace.

  2. Alignment strategies for the entrainment of music and movement rhythms.

    PubMed

    Moens, Bart; Leman, Marc

    2015-03-01

    Theories of entrainment assume that spontaneous entrainment emerges from dynamic laws that operate via mediators on interactions, whereby entrainment is facilitated if certain conditions are fulfilled. In this study, we show that mediators can be built that affect the entrainment of human locomotion to music. More specifically, we built D-Jogger, a music player that functions as a mediator between music and locomotion rhythms. The D-Jogger makes it possible to manipulate the timing differences between salient moments of the rhythms (beats and footfalls) through the manipulation of the musical period and phase, which affect the condition in which entrainment functions. We conducted several experiments to explore different strategies for manipulating the entrainment of locomotion and music. The results of these experiments showed that spontaneous entrainment can be manipulated, thereby suggesting different strategies on how to embark. The findings furthermore suggest a distinction among different modalities of entrainment: finding the beat (the most difficult part of entrainment), keeping the beat (easier, as a temporal scheme has been established), and being in phase (no entrainment is needed because the music is always adapted to the human rhythm). This study points to a new avenue of research on entrainment and opens new perspectives for the neuroscience of music.

  3. Partial entrainment in the finite Kuramoto Sakaguchi model

    NASA Astrophysics Data System (ADS)

    De Smet, Filip; Aeyels, Dirk

    2007-10-01

    Although modifications of the Kuramoto model have been the subject of extensive research, the model itself is not yet fully understood. We offer several results and observations, some analytic, others through simulations. We derive a sufficient condition for the existence of a solution exhibiting partial entrainment with respect to a given subset of oscillators; the result also implies persistence of the entrainment behavior under perturbations. The critical values of the coupling strength, defining the transitions between different forms of partial entrainment, are predicted by an analytical approximation, based on the fact that oscillators with large differences in their natural frequencies have little influence on each other’s entrainment behavior; the predictions agree with the actual values, obtained by simulations. We indicate (by simulations) that entrainment can disappear with increasing coupling strength, and that, in arrays of Josephson junctions, a similar phenomenon can be observed, where it is also possible that a junction leaving one entrained subset joins another entrained subset.

  4. Rod Driven Frequency Entrainment and Resonance Phenomena.

    PubMed

    Salchow, Christina; Strohmeier, Daniel; Klee, Sascha; Jannek, Dunja; Schiecke, Karin; Witte, Herbert; Nehorai, Arye; Haueisen, Jens

    2016-01-01

    A controversy exists on photic driving in the human visual cortex evoked by intermittent photic stimulation. Frequency entrainment and resonance phenomena are reported for frequencies higher than 12 Hz in some studies while missing in others. We hypothesized that this might be due to different experimental conditions, since both high and low intensity light stimulation were used. However, most studies do not report radiometric measurements, which makes it impossible to categorize the stimulation according to photopic, mesopic, and scotopic vision. Low intensity light stimulation might lead to scotopic vision, where rod perception dominates. In this study, we investigated photic driving for rod-dominated visual input under scotopic conditions. Twelve healthy volunteers were stimulated with low intensity light flashes at 20 stimulation frequencies, leading to rod activation only. The frequencies were multiples of the individual alpha frequency (α) of each volunteer in the range from 0.40 to 2.30(∗)α. Three hundred and six-channel whole head magnetoencephalography recordings were analyzed in time, frequency, and spatiotemporal domains with the Topographic Matching Pursuit algorithm. We found resonance phenomena and frequency entrainment for stimulations at or close to the individual alpha frequency (0.90-1.10(∗)α) and half of the alpha frequency (0.40-0.55(∗)α). No signs of resonance and frequency entrainment phenomena were revealed around 2.00(∗)α. Instead, on-responses at the beginning and off-responses at the end of each stimulation train were observed for the first time in a photic driving experiment at frequencies of 1.30-2.30(∗)α, indicating that the flicker fusion threshold was reached. All results, the resonance and entrainment as well as the fusion effects, provide evidence for rod-dominated photic driving in the visual cortex.

  5. Maternal entrainment of tau mutant hamsters.

    PubMed

    Viswanathan, N; Davis, F C

    1992-01-01

    Maternal entrainment of the circadian wheel-running activity rhythm was examined in Syrian hamsters heterozygous for a single gene mutation (tau) that affects the free-running period of circadian rhythms. Heterozygous tau pups were born to and raised by wild-type mothers under constant dim light. The pups' wheel-running activity was recorded after weaning on postnatal day 18 or 24. Pups weaned on day 18 had an average free-running period of 21.70 hr, demonstrating that the tau phenotype was fully expressed at this age. Using the activity onset of the postnatal free-running rhythms as a phase reference, we estimated the phase relationships between the pups and their mothers on days 18 and 24. In contrast to results with wild-type pups, the activity rhythms of tau pups were not in phase with the rhythms of their wild-type mothers; that is, activity onsets of mothers and pups did not coincide. The pups did, however, show synchrony among themselves, indicating that they had been exposed to a synchronizing signal sometime during development. It is likely that this synchronizing signal was provided by the mothers, since pups from different litters showed phase relationships similar to those of their mothers. Thus the mothers provided a signal that was sufficient to cause entrainment, despite the 2-hr difference in free-running period between the mothers and pups. Although the pups' activity rhythms appeared to have been entrained by the mothers, they were clearly free-running by postnatal day 18. The mechanism for entrainment is lost during the course of development, despite continued interaction between the mothers and pups.

  6. Rod Driven Frequency Entrainment and Resonance Phenomena

    PubMed Central

    Salchow, Christina; Strohmeier, Daniel; Klee, Sascha; Jannek, Dunja; Schiecke, Karin; Witte, Herbert; Nehorai, Arye; Haueisen, Jens

    2016-01-01

    A controversy exists on photic driving in the human visual cortex evoked by intermittent photic stimulation. Frequency entrainment and resonance phenomena are reported for frequencies higher than 12 Hz in some studies while missing in others. We hypothesized that this might be due to different experimental conditions, since both high and low intensity light stimulation were used. However, most studies do not report radiometric measurements, which makes it impossible to categorize the stimulation according to photopic, mesopic, and scotopic vision. Low intensity light stimulation might lead to scotopic vision, where rod perception dominates. In this study, we investigated photic driving for rod-dominated visual input under scotopic conditions. Twelve healthy volunteers were stimulated with low intensity light flashes at 20 stimulation frequencies, leading to rod activation only. The frequencies were multiples of the individual alpha frequency (α) of each volunteer in the range from 0.40 to 2.30∗α. Three hundred and six-channel whole head magnetoencephalography recordings were analyzed in time, frequency, and spatiotemporal domains with the Topographic Matching Pursuit algorithm. We found resonance phenomena and frequency entrainment for stimulations at or close to the individual alpha frequency (0.90–1.10∗α) and half of the alpha frequency (0.40–0.55∗α). No signs of resonance and frequency entrainment phenomena were revealed around 2.00∗α. Instead, on-responses at the beginning and off-responses at the end of each stimulation train were observed for the first time in a photic driving experiment at frequencies of 1.30–2.30∗α, indicating that the flicker fusion threshold was reached. All results, the resonance and entrainment as well as the fusion effects, provide evidence for rod-dominated photic driving in the visual cortex. PMID:27588002

  7. Diurnally Entrained Anticipatory Behavior in Archaea

    PubMed Central

    Whitehead, Kenia; Pan, Min; Masumura, Ken-ichi; Bonneau, Richard; Baliga, Nitin S.

    2009-01-01

    By sensing changes in one or few environmental factors biological systems can anticipate future changes in multiple factors over a wide range of time scales (daily to seasonal). This anticipatory behavior is important to the fitness of diverse species, and in context of the diurnal cycle it is overall typical of eukaryotes and some photoautotrophic bacteria but is yet to be observed in archaea. Here, we report the first observation of light-dark (LD)-entrained diurnal oscillatory transcription in up to 12% of all genes of a halophilic archaeon Halobacterium salinarum NRC-1. Significantly, the diurnally entrained transcription was observed under constant darkness after removal of the LD stimulus (free-running rhythms). The memory of diurnal entrainment was also associated with the synchronization of oxic and anoxic physiologies to the LD cycle. Our results suggest that under nutrient limited conditions halophilic archaea take advantage of the causal influence of sunlight (via temperature) on O2 diffusivity in a closed hypersaline environment to streamline their physiology and operate oxically during nighttime and anoxically during daytime. PMID:19424498

  8. The effect of acceleration on turbulent entrainment

    NASA Astrophysics Data System (ADS)

    Breidenthal, Robert E.

    2008-12-01

    A new class of self-similar turbulent flows is proposed, which exhibits dramatically reduced entrainment rates. Under strong acceleration, the rotation period of the large-scale vortices is forced to decrease linearly in time. In ordinary unforced turbulence, the rotation period always increases linearly with time, at least in the mean. However, by imposing an exponential acceleration on the flow, the vortex rotation period is forced to become the e-folding timescale of the acceleration. If the e-folding timescale itself decreases linearly in time, the forcing is 'super-exponential', characterized by an acceleration parameter α. Based on dimensional and heuristic arguments, a model suggests that the dissipation rate is an exponential function of α and the dimensions of the conserved quantity of the flow. Acceleration decreases the dissipation and entrainment rates in all canonical laboratory flows except for Rayleigh-Taylor. Experiments of exponential jets and super-exponential transverse jets are in accord with the model. As noted by Johari, acceleration is the only known means of affecting the entrainment rate of the far-field jet. Numerical simulations of Rayleigh-Taylor flow by Cook and Greenough are also consistent. In the limit of large acceleration, vortices do not move far before their rotation period changes substantially. In this sense, extreme acceleration corresponds to stationary vortices.

  9. Analysis of locus D9S1120 and its genetic admixture correlation in seven argentina native american ethnic groups.

    PubMed

    Caputo, Mariela; Corach, Daniel

    2016-01-01

    Genetic data have complemented archaeological and linguistic investigations for understanding the peopling of the Americas. Aiming to investigate the Native South American genetic background in Argentina, seven Amerindian and one urban population were selected. The analysis focused on locus D9S1120 due to its potential anthropological information about Native American origins. The sample set included 603 individuals belonging to nine isolated Argentinean aboriginal communities from seven tribes (N = 296), 100 individuals living in Buenos Aires city, and three potentially parental population references samples (N = 207). We computed allele and genotype frequency distributions, genetic distances, and pairwise differences among and within them. Admixture proportion was determined by means of typing 13 autosomal short tandem repeats plus D9S1120 in all populations, and comparing the data with those from three parental groups including Native American, European and Sub Saharan West African. The Native American-specific allele 9RA was found at an average frequency of 0.26 in aboriginal groups. Statistically significant differences were observed among the Native American groups when compared with the Buenos Aires urban population using analysis of molecular variance (AMOVA) (Fst = 0.05669; P < 0.0001). Admixture analysis denoted different results between the cohorts of Amerindian samples displaying the specific 9RA allele, compared with those lacking it. A linear correlation was established between positive 9RA and Native American ancestry. Autosomal-based genetic admixture showed that the studied communities have considerable European and Native America contributions. Our results concerning D9S1120 further contribute to a better understanding of the admixture process between Sub Saharan African, Native American, and European individuals that shaped the genetic background of Argentinean extant population. © 2015 Wiley Periodicals, Inc.

  10. The transmission/disequilibrium test: history, subdivision, and admixture.

    PubMed Central

    Ewens, W J; Spielman, R S

    1995-01-01

    Disease association with a genetic marker is often taken as a preliminary indication of linkage with disease susceptibility. However, population subdivision and admixture may lead to disease association even in the absence of linkage. In a previous paper, we described a test for linkage (and linkage disequilibrium) between a genetic marker and disease susceptibility; linkage is detected by this test only if association is also present. This transmission/disequilibrium test (TDT) is carried out with data on transmission of marker alleles from parents heterozygous for the marker to affected offspring. The TDT is a valid test for linkage and association, even when the association is caused by population subdivision and admixture. In the previous paper, we did not explicitly consider the effect of recent history on population structure. Here we extend the previous results by examining in detail the effects of subdivision and admixture, viewed as processes in population history. We describe two models for these processes. For both models, we analyze the properties of (a) the TDT as a test for linkage (and association) between marker and disease and (b) the conventional contingency statistic used with family data to test for population association. We show that the contingency test statistic does not have a chi 2 distribution if subdivision or admixture is present. In contrast, the TDT remains a valid chi 2 statistic for the linkage hypothesis, regardless of population history. PMID:7668272

  11. Worldwide patterns of genomic variation and admixture in gray wolves.

    PubMed

    Fan, Zhenxin; Silva, Pedro; Gronau, Ilan; Wang, Shuoguo; Armero, Aitor Serres; Schweizer, Rena M; Ramirez, Oscar; Pollinger, John; Galaverni, Marco; Ortega Del-Vecchyo, Diego; Du, Lianming; Zhang, Wenping; Zhang, Zhihe; Xing, Jinchuan; Vilà, Carles; Marques-Bonet, Tomas; Godinho, Raquel; Yue, Bisong; Wayne, Robert K

    2016-02-01

    The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic. © 2016 Fan et al.; Published by Cold Spring Harbor Laboratory Press.

  12. Strong selection at MHC in Mexicans since admixture

    USDA-ARS?s Scientific Manuscript database

    Mexicans are a recent admixture of Amerindians, Europeans, and Africans. We performed local ancestry analysis of Mexican samples from two genome-wide association studies obtained from dbGaP, and discovered that at the major histocompatibility complex (MHC) region Mexicans have excessive African ance...

  13. Population admixture and high larval viability among urban toads

    PubMed Central

    Hase, Kazuko; Nikoh, Naruo; Shimada, Masakazu

    2013-01-01

    In terms of evolutionary biology, a population admixture of more than two distinct lineages may lead to strengthened genetic variation through hybridization. However, a population admixture arising from artificial secondary contact poses significant problems in conservation biology. In urban Tokyo, a population admixture has emerged from two lineages of Japanese common toad: native Bufo japonicus formosus and nonnative B. japonicus japonicus, of which the latter was introduced in the early 20th century. To evaluate the degree of genetic disturbance in the admixed population of these two subspecies, we analyzed genotypes of toads distributed within and outside Tokyo by assessing mtDNA and seven microsatellite loci. We found that the introduced B. japonicus japonicus genotype dominates six local populations in the Tokyo admixture zone and was clearly derived from past introgressive hybridization between the two subspecies. These observations were supported by morphological assessments. Furthermore, the average larval survival rate in Tokyo was significantly higher than that outside Tokyo, suggesting that the temporary contribution of introduced toads occurred through introgression. The fitness of toads in urban Tokyo may thus be increasing with the assistance of nonnative individuals. PMID:23789077

  14. A Spatial Framework for Understanding Population Structure and Admixture

    PubMed Central

    Bradburd, Gideon S.; Ralph, Peter L.; Coop, Graham M.

    2016-01-01

    Geographic patterns of genetic variation within modern populations, produced by complex histories of migration, can be difficult to infer and visually summarize. A general consequence of geographically limited dispersal is that samples from nearby locations tend to be more closely related than samples from distant locations, and so genetic covariance often recapitulates geographic proximity. We use genome-wide polymorphism data to build “geogenetic maps,” which, when applied to stationary populations, produces a map of the geographic positions of the populations, but with distances distorted to reflect historical rates of gene flow. In the underlying model, allele frequency covariance is a decreasing function of geogenetic distance, and nonlocal gene flow such as admixture can be identified as anomalously strong covariance over long distances. This admixture is explicitly co-estimated and depicted as arrows, from the source of admixture to the recipient, on the geogenetic map. We demonstrate the utility of this method on a circum-Tibetan sampling of the greenish warbler (Phylloscopus trochiloides), in which we find evidence for gene flow between the adjacent, terminal populations of the ring species. We also analyze a global sampling of human populations, for which we largely recover the geography of the sampling, with support for significant histories of admixture in many samples. This new tool for understanding and visualizing patterns of population structure is implemented in a Bayesian framework in the program SpaceMix. PMID:26771578

  15. Microbiologic quality assurance for intravenous admixtures in a small hospital.

    PubMed

    Doss, H L; James, J D; Killough, D M; Snodgrass, G L

    1982-05-01

    A simple, inexpensive method for end-product testing of intravenous admixtures for microbial contamination was developed and tested by challenging the system with low levels of microbial contamination. The 16-step procedure for testing i.v. admixtures for microbial contamination used total-sample membrane filtration A 0.2-micrometers Nalgene filter unit was used; the entire contents of randomly selected admixtures were to be filtered and discarded under the procedure. Filters were incubated on sheep-blood agar plates for 48 hours at 35 degrees C. Low concentrations (Klebsiella pneumoniae and Pseudomonas aeruginosa were used to contaminate admixtures deliberately to challenge the system. Seventy-two solutions were contaminated with each microbe; 72 other solutions were inoculated with sterile 0.9% sodium chloride; and 72 uninoculated solutions served as controls. Filtration was performed on a laboratory bench to prevent contamination of the laminar-flow hood. In deliberately contaminated solutions, a mean of 82% of inoculated organisms was isolated by membrane filtration. Five instances of adventitious contamination were noted among the 288 samples; these occurred across all experimental groups. Cost per sample was $4-5. This system can be used by hospital pharmacists to produce documentation of quality assurance that will be acceptable in terms of cost, simplicity, and accuracy.

  16. Worldwide patterns of genomic variation and admixture in gray wolves

    PubMed Central

    Fan, Zhenxin; Silva, Pedro; Gronau, Ilan; Wang, Shuoguo; Armero, Aitor Serres; Schweizer, Rena M.; Ramirez, Oscar; Pollinger, John; Galaverni, Marco; Ortega Del-Vecchyo, Diego; Du, Lianming; Zhang, Wenping; Zhang, Zhihe; Xing, Jinchuan; Vilà, Carles; Marques-Bonet, Tomas; Godinho, Raquel; Yue, Bisong; Wayne, Robert K.

    2016-01-01

    The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter–gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic. PMID:26680994

  17. The transmission/disequilibrium test: History, subdivision, and admixture

    SciTech Connect

    Ewens, W.J.; Spielman, R.S.

    1995-08-01

    Disease association with a genetic marker is often taken as a preliminary indication of linkage with disease susceptibility. However, population subdivision and admixture may lead to diease association even in the absence of linkage. In a previous paper, we described a test for linkage (and linkage disequilibrium) between a genetic marker and disease susceptibility; linkage is detected by this test only if association is also present. This transmission/disequilibrium test (TDT) is carried out with data on transmission of marker alleles from parents heterozygous for the marker alleles to affected offspring. The TDT is a valid test for linkage and association, even when the association is caused by population subdivision and admixture. In the previous paper, we did not explicitly consider the effect of recent history on population structure. Here we extend the previous results by examining in detail the effects of subdivision and admixture, viewed as processes in population history. We describe two models for these processes. For both models, we analyze the properties of (a) the TDT as a test for linkage (and association) between marker and disease and (b) the conventional contingency statistic used with family data to test for population association. We show that the contingency test statistic does not have a {chi}{sup 2} distribution if subdivision or admixture is present. In contrast, the TDT remains a valid {chi}{sub 2} statistic for the linkage hypothesis, regardless of population history. 20 refs., 2 figs., 5 tabs.

  18. Foaming and Antifoaming and Gas Entrainment in Radioactive Waste Preteatment and Immobilization Processes

    SciTech Connect

    Wasan, Darsh T.; Nikolov, Alex

    2005-06-01

    The objectives of this research effort are to develop a fundamental understanding of the physico-chemical mechanisms that produce foaming and air entrainment in the DOE High Level (HLW) and Low Activity (LAW) radioactive waste separation and immobilization processes, and to develop and test advanced antifoam/defoaming/rheology modifier agents. Antifoams/rheology modifiers developed from this research will be tested using non-radioactive simulants of the radioactive wastes obtained from Hanford and the Savannah River Site (SRS).

  19. Optimizing the Entrainment Geometry of a Dry Powder Inhaler: Methodology and Preliminary Results.

    PubMed

    Kopsch, Thomas; Murnane, Darragh; Symons, Digby

    2016-11-01

    For passive dry powder inhalers (DPIs) entrainment and emission of the aerosolized drug dose depends strongly on device geometry and the patient's inhalation manoeuvre. We propose a computational method for optimizing the entrainment part of a DPI. The approach assumes that the pulmonary delivery location of aerosol can be determined by the timing of dose emission into the tidal airstream. An optimization algorithm was used to iteratively perform computational fluid dynamic (CFD) simulations of the drug emission of a DPI. The algorithm seeks to improve performance by changing the device geometry. Objectives were to achieve drug emission that was: A) independent of inhalation manoeuvre; B) similar to a target profile. The simulations used complete inhalation flow-rate profiles generated dependent on the device resistance. The CFD solver was OpenFOAM with drug/air flow simulated by the Eulerian-Eulerian method. To demonstrate the method, a 2D geometry was optimized for inhalation independence (comparing two breath profiles) and an early-bolus delivery. Entrainment was both shear-driven and gas-assisted. Optimization for a delay in the bolus delivery was not possible with the chosen geometry. Computational optimization of a DPI geometry for most similar drug delivery has been accomplished for an example entrainment geometry.

  20. Liquid entrainment at an upward oriented vertical branch line from a horizontal pipe

    NASA Astrophysics Data System (ADS)

    Welter, Kent Byron

    Under simulated accident conditions, tees in the primary coolant loop of a Pressurized Water Reactor (PWR) can deviate from their original design purpose and become separators that effectively remove core heat sink capacity. This method of primary coolant removal is a phenomenological subset of phase separation known as liquid entrainment, whereby liquid is forced from its original path by the inertia of the gas. A comprehensive literature review revealed common deficiencies in previous studies. The Westinghouse AP600 advanced reactor design was chosen to assess the validity of entrainment models. Following a systematic scaling analysis of the prototypic design a model separate effects test was proposed and constructed at Oregon State University. Just under 100 tests were run to fill the deficiencies found in the literature review. New data from the Air-water Test Loop for Advanced Thermal-hydraulic Studies (ATLATS) could not be predicted by published correlations. A new theoretical model for predicting liquid entrainment onset and steady state entrainment was developed. Comparison with all available data shows a marked improvement for predicting the mass flow rate out the vertical branch.

  1. Viscous-inviscid calculations of jet entrainment effects on the subsonic flow over nozzle afterbodies

    NASA Technical Reports Server (NTRS)

    Wilmoth, R. G.

    1980-01-01

    A viscous-inviscid interaction model was developed to account for jet entrainment effects in the prediction of the subsonic flow over nozzle afterbodies. The model is based on the concept of a weakly interacting shear layer in which the local streamline deflections due to entrainment are accounted for by a displacement-thickness type of correction to the inviscid plume boundary. The entire flow field is solved in an iterative manner to account for the effects on the inviscid external flow of the turbulent boundary layer, turbulent mixing and chemical reactions in the shear layer, and the inviscid jet exhaust flow. The components of the computational model are described, and numerical results are presented to illustrate the interactive effects of entrainment on the overall flow structure. The validity of the model is assessed by comparisons with data obtained form flow-field measurements on cold-air jet exhausts. Numerical results and experimental data are also given to show the entrainment effects on nozzle boattail drag under various jet exhaust and free-stream flow conditions.

  2. Entrained liquid fraction calculation in adiabatic disperse-annular flows at low rate in film

    NASA Astrophysics Data System (ADS)

    Yagov, V. V.; Minko, M. V.

    2016-04-01

    In this work, we continue our study [1] and extend further an approach to low reduced pressures. An approximate model of droplets entrainment from the laminar film surface and an equation for calculating entrainment intensity are proposed. To carry out direct verification of this equation using experimental data is extremely difficult because the integral effect—liquid flow rate in a film at a dynamic equilibrium between entrainment and deposition—is usually measured in the experiments. The balance between flows of droplets entrainment and deposition corresponds to the dynamic equilibrium because of turbulent diffusion. The transcendental equation, which was obtained on the basis of this balance, contains one unknown numerical factor and allows one to calculate the liquid rate. Comparing calculation results with the experimental data for the water-air and water-helium flows at low reduced pressures (less than 0.03) has shown their good agreement at the universal value of a numerical constant, if an additional dimensionless parameter, a fourth root of vaporliquid densities ratio, is introduced. The criterion that determines the boundary of using methods of this work and that of [1] in calculations and that reflects effect of pressure and state of film surface on distribution of the liquid in the annular flow is proposed; the numerical value of this criterion has been determined.

  3. The role of induced entrainment in past stratiform cloud seeding experiments

    NASA Astrophysics Data System (ADS)

    Walcek, C. J.

    2010-12-01

    In the late 1940s, probably the most effective and visually-obvious cloud seeding demonstrations showed that supercooled stratiform clouds could be cleared by seeding with dry ice, dropped from aircraft flying above a cloud deck. Numerous well-documents photos show areas 1-2 miles wide cleared along a flight track. The accepted mechanism of cloud clearing assumed that dry ice induced ice formation in the supercooled liquid cloud, followed by growth of ice at the expense of water, with the larger ice particles ultimately falling as snow. The mechanism was amplified by dynamic feedbacks induced by latent heat release (warming) as liquid water froze, thus propagating the dynamic and freezing/precipitation cycle laterally away from the flight track. Here we show that probably a more important effect is the entrainment and EVAPORATION of cloud water induced by turbulent mixing in the aircraft wake. Under many conditions, evaporation induced by turbulence can generate mixtures of air that are COLDER than the cloudy air or the air above the cloud, thus initiating unstable DOWNWARD (negatively-buoyant) motions, which will self-propagate laterally away from a turbulent flight track. We present here the range of environmental conditions where entrainment/evaporation would be most likely to occur in terms of the temperature difference between cloudy air and air just above cloud top, and the relative humidity of air above cloud top at different temperatures and altitudes in the atmosphere. It is suggested here that past cloud seeding experiments had little to do with glaciation, and more likely resulted from induced entrainment followed by evaporation and downward motions of negatively buoyant air resulting from cloud-top entrainment instability. Buoyancy and condensed water content of mixtures of cloudy air and cloud-free air immediately above cloud top vs. the mixing proportions. A supercooled cloud containing 0.1 g/kg liquid water at 600 mb, -20 degrees C is mixed with air

  4. How to Achieve Fast Entrainment? The Timescale to Synchronization

    PubMed Central

    Granada, Adrián E.; Herzel, Hanspeter

    2009-01-01

    Entrainment, where oscillators synchronize to an external signal, is ubiquitous in nature. The transient time leading to entrainment plays a major role in many biological processes. Our goal is to unveil the specific dynamics that leads to fast entrainment. By studying a generic model, we characterize the transient time to entrainment and show how it is governed by two basic properties of an oscillator: the radial relaxation time and the phase velocity distribution around the limit cycle. Those two basic properties are inherent in every oscillator. This concept can be applied to many biological systems to predict the average transient time to entrainment or to infer properties of the underlying oscillator from the observed transients. We found that both a sinusoidal oscillator with fast radial relaxation and a spike-like oscillator with slow radial relaxation give rise to fast entrainment. As an example, we discuss the jet-lag experiments in the mammalian circadian pacemaker. PMID:19774087

  5. Differential rescue of light- and food-entrainable circadian rhythms.

    PubMed

    Fuller, Patrick M; Lu, Jun; Saper, Clifford B

    2008-05-23

    When food is plentiful, circadian rhythms of animals are powerfully entrained by the light-dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift most of their circadian rhythms to match the food availability. We studied the basis for entrainment of circadian rhythms by food and light in mice with targeted disruption of the clock gene Bmal1, which lack circadian rhythmicity. Injection of a viral vector containing the Bmal1 gene into the suprachiasmatic nuclei of the hypothalamus restored light-entrainable, but not food-entrainable, circadian rhythms. In contrast, restoration of the Bmal1 gene only in the dorsomedial hypothalamic nucleus restored the ability of animals to entrain to food but not to light. These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms.

  6. Entrainment and mixing in thrust augmenting ejectors

    NASA Technical Reports Server (NTRS)

    Bernal, L.; Sarohia, V.

    1983-01-01

    An experimental investigation of two-dimensional thrust augmenting ejector flows has been conducted. Measurements of the shroud surface pressure distribution, mean velocity, turbulent intensities and Reynolds stresses were made in two shroud geometries at various primary nozzle pressure ratios. The effects of shroud geometry and primary nozzle pressure ratio on the shroud surface pressure distribution, mean flow field and turbulent field were determined. From these measurements the evolution of mixing within the shroud of the primary flow and entrained fluid was obtained. The relationship between the mean flow field, the turbulent field and the shroud surface pressure distribution is discussed.

  7. On-line ultrasonic gas entrainment monitor

    DOEpatents

    Day, Clifford K.; Pedersen, Herbert N.

    1978-01-01

    Apparatus employing ultrasonic energy for detecting and measuring the quantity of gas bubbles present in liquids being transported through pipes. An ultrasonic transducer is positioned along the longitudinal axis of a fluid duct, oriented to transmit acoustic energy radially of the duct around the circumference of the enclosure walls. The back-reflected energy is received centrally of the duct and interpreted as a measure of gas entrainment. One specific embodiment employs a conical reflector to direct the transmitted acoustic energy radially of the duct and redirect the reflected energy back to the transducer for reception. A modified embodiment employs a cylindrical ultrasonic transducer for this purpose.

  8. A comparison of three methods for assessing Amerindian admixture in Mexican Americans.

    PubMed

    Mitchell, B D; Williams-Blangero, S; Chakraborty, R; Valdez, R; Hazuda, H P; Haffner, S M; Stern, M P

    1993-01-01

    Epidemiologic studies have revealed that Mexican Americans experience an excess of non-insulin-dependent diabetes mellitus, gallbladder disease, and obesity relative to non-Hispanic whites. It has been hypothesized that the greater susceptibility of Mexican Americans to these disorders may be related to their greater degree of Amerindian genetic admixture. We evaluate the comparability of three different methods of assessing individual genetic admixture in Mexican Americans. Subjects were enrolled as part of the San Antonio Heart Study and were examined between 1979 and 1988 (n = 3301). Three different methods were used to assess Amerindian admixture: we queried subjects about their ancestors' ethnic origin, we measured subjects' skin color, and we estimated genetic admixture directly by analysis of polymorphic blood markers. These measures were generally poorly correlated with each other, with the highest correlations observed between skin color and proportion of Mexican-origin grandparents. In men, none of these three measures of genetic admixture was associated with the prevalence of diabetes, gallbladder disease, or obesity. In women, consistent positive associations were observed between admixture and all three diseases, regardless of the admixture measure used (ie, disease prevalence was higher among women with more Amerindian admixture). In both sexes, height was negatively correlated with all three measures of admixture, and admixture was also significantly correlated with body mass index and central adiposity in women. These data suggest that the three measures considered may assess different dimensions of admixture, but that for epidemiologic research, no one may be claimed to be superior to the others.

  9. Alkali-silicate admixture for cement composites incorporating pozzolan or blast furnace slag

    SciTech Connect

    Zivica, V. . Inst. of construction and Architecture)

    1993-09-01

    This research was devoted to the study of the influence of the developed alkali-silicate admixture (AS admixture) on mortar properties. The obtained results shown that the admixture significantly increased the strength of the mortars made from portland cement (PC) and silica fume (SF) or blast furnace slag (SL). For example after 24 h hardening of mortar (30% SF + 70% PC), with the admixture, reached value of compression strength 18,7 MPa opposite to the value of 5.6 MPa of control mortar (100% PC). The same accelerating effect of AS admixture was observed also with mortar incorporating slag and with slag mortar (100% SL). Further results show that the mortars with AS admixture had an increased content of hydration products and substantially more dense pore structure than mortars of the same composition, but without the admixture.

  10. On the use of crystalline admixtures in cement based construction materials: from porosity reducers to promoters of self healing

    NASA Astrophysics Data System (ADS)

    Ferrara, Liberato; Krelani, Visar; Moretti, Fabio

    2016-08-01

    The project detailed in this paper aims at a thorough characterization of the effects of crystalline admixtures, currently employed as porosity reducing admixtures, on the self-healing capacity of the cementitious composites, i.e. their capacity to completely or partially re-seal cracks and, in case, also exhibit recovery of mechanical properties. The problem has been investigated with reference to both a normal strength concrete (NSC) and a high performance fibre reinforced cementitious composite (HPFRCC). In the latter case, the influence of flow-induced fibre alignment has also been considered in the experimental investigation. With reference to either 3-point (for NSC) or 4-point (for HPFRCC) bending tests performed up to controlled crack opening and up to failure, respectively before and after exposure/conditioning recovery of stiffness and stress bearing capacity has been evaluated to assess the self-healing capacity. In a durability-based design framework, self-healing indices to quantify the recovery of mechanical properties will also be defined. In NSC, crystalline admixtures are able to promote up to 60% of crack sealing even under exposure to open air. In the case of HPFRCCs, which would already feature autogenous healing capacity because of their peculiar mix compositions, the synergy between the dispersed fibre reinforcement and the action of the crystalline admixture has resulted in a likely ‘chemical pre-stressing’ of the same reinforcement, from which the recovery of mechanical performance of the material has greatly benefited, up to levels even higher than the performance of the virgin un-cracked material.

  11. Spontaneous motor entrainment to music in multiple vocal mimicking species.

    PubMed

    Schachner, Adena; Brady, Timothy F; Pepperberg, Irene M; Hauser, Marc D

    2009-05-26

    The human capacity for music consists of certain core phenomena, including the tendency to entrain, or align movement, to an external auditory pulse [1-3]. This ability, fundamental both for music production and for coordinated dance, has been repeatedly highlighted as uniquely human [4-11]. However, it has recently been hypothesized that entrainment evolved as a by-product of vocal mimicry, generating the strong prediction that only vocal mimicking animals may be able to entrain [12, 13]. Here we provide comparative data demonstrating the existence of two proficient vocal mimicking nonhuman animals (parrots) that entrain to music, spontaneously producing synchronized movements resembling human dance. We also provide an extensive comparative data set from a global video database systematically analyzed for evidence of entrainment in hundreds of species both capable and incapable of vocal mimicry. Despite the higher representation of vocal nonmimics in the database and comparable exposure of mimics and nonmimics to humans and music, only vocal mimics showed evidence of entrainment. We conclude that entrainment is not unique to humans and that the distribution of entrainment across species supports the hypothesis that entrainment evolved as a by-product of selection for vocal mimicry.

  12. Conditions for super-adiabatic droplet growth after entrainment mixing

    DOE PAGES

    Yang, Fan; Shaw, Raymond; Xue, Huiwen

    2016-07-29

    Cloud droplet response to entrainment and mixing between a cloud and its environment is considered, accounting for subsequent droplet growth during adiabatic ascent following a mixing event. The vertical profile for liquid water mixing ratio after a mixing event is derived analytically, allowing the reduction to be predicted from the mixing fraction and from the temperature and humidity for both the cloud and environment. It is derived for the limit of homogeneous mixing. The expression leads to a critical height above the mixing level: at the critical height the cloud droplet radius is the same for both mixed and unmixedmore » parcels, and the critical height is independent of the updraft velocity and mixing fraction. Cloud droplets in a mixed parcel are larger than in an unmixed parcel above the critical height, which we refer to as the “super-adiabatic” growth region. Analytical results are confirmed with a bin microphysics cloud model. Using the model, we explore the effects of updraft velocity, aerosol source in the environmental air, and polydisperse cloud droplets. Results show that the mixed parcel is more likely to reach the super-adiabatic growth region when the environmental air is humid and clean. It is also confirmed that the analytical predictions are matched by the volume-mean cloud droplet radius for polydisperse size distributions. The findings have implications for the origin of large cloud droplets that may contribute to onset of collision–coalescence in warm clouds.« less

  13. Entrainment, Drizzle, and the Indirect Effect in Stratiform Clouds

    NASA Technical Reports Server (NTRS)

    Ackerman, Andrew

    2005-01-01

    Activation of some fraction of increased concentrations of sub-micron soluble aerosol particles lead to enhanced cloud droplet concentrations and hence smaller droplets, increasing their total cross sectional area and thus reflecting solar radiation more efficiently (the Twomey, or first indirect, effect). However, because of competition during condensational growth, droplet distributions tend to broaden as numbers increase, reducing the sensitivity of cloud albedo to droplet concentration on the order of 10%. Also, smaller droplets less effectively produce drizzle through collisions and coalescence, and it is widely expected (and found in large-scale models) that decreased precipitation leads to clouds with more cloud water on average (the so-called cloud lifetime, or second indirect, effect). Much of the uncertainty regarding the overall indirect aerosol effect stems from inadequate understanding of such changes in cloud water. Detailed simulations based on FIRE-I, ASTEX, and DYCOMS-II conditions show that suppression of precipitation from increased droplet concentrations leads to increased cloud water only when sufficient precipitation reaches the surface, a condition favored when the overlying air is-humid or droplet concentrations are very low. Otherwise, aerosol induced suppression of precipitation enhances entrainment of overlying dry air, thereby reducing cloud water and diminishing the indirect climate forcing.

  14. Entrainment control in the Aplysia buccal ganglion

    NASA Astrophysics Data System (ADS)

    Hunter, John D.; Milton, John G.

    2000-03-01

    Many dynamical systems, such as neural networks, can be pushed into or out of an entrained state by varying a system parameter. However, implementing this control strategy in a real biological system remains a difficult problem since many biological effectors have multiple effects. An example is an inhibitory interneuron that generates a postsynaptic current with a constant component, which alters the firing rate of its target, and a time-varying component, which can have a variety of effects. Here we explore the effects of an inhibitory interneuron on the ability of a regularly spiking Aplysia buccal motoneuron to synchronize to an external periodic input. After measuring the Arnold tongue structure of the motoneuron's response to sinusoidal input, we drive the motoneuron to and from an entrained state (onto and off of a tongue) by using the interneuron as a rate controller. These observations indicate that rate control of synchronization is robust even in the case when effectors have multiple actions. Moreover, these results provide direct evidence that inhibitory interneurons can serve as a sensitive mechanism to control the synchronization of neural populations by producing only slight changes in neural firing rate.

  15. Convective entrainment deduced from biomass burning plume ingestion at altitude during the 2012 DC3 airborne field project

    NASA Astrophysics Data System (ADS)

    Ryerson, T. B.; Pollack, I. B.; Peischl, J.; Wisthaler, A.; Mikoviny, T.; Diskin, G. S.; Sachse, G. W.; Beyersdorf, A. J.; Choi, Y.; Blake, D. R.; Dibb, J. E.; Scheuer, E. M.

    2012-12-01

    We present airborne measurements of atmospheric chemical species in the vicinity of an evolving isolated supercell thunderstorm, taken aboard the NASA DC-8 instrumented research aircraft on June 22, 2012, during the Deep Convective Clouds and Chemistry (DC3) project. The aircraft study over the course of 2 hours sampled boundary layer and free tropospheric inflow regions as well as outflow in the cirrus anvil and downwind. Chemical measurements at outflow altitudes of 10 km prior to and following entrainment of a biomass burning plume, primarily ingested at 8 km, are used to calculate the fraction of air lofted directly from the convective surface layer and that entrained from the middle free troposphere.

  16. The phenotypic legacy of admixture between modern humans and Neanderthals

    PubMed Central

    Simonti, Corinne N.; Vernot, Benjamin; Bastarache, Lisa; Bottinger, Erwin; Carrell, David S.; Chisholm, Rex L.; Crosslin, David R.; Hebbring, Scott J.; Jarvik, Gail P.; Kullo, Iftikhar J.; Li, Rongling; Pathak, Jyotishman; Ritchie, Marylyn D.; Roden, Dan M.; Verma, Shefali S.; Tromp, Gerard; Prato, Jeffrey D.; Bush, William S.; Akey, Joshua M.; Denny, Joshua C.; Capra, John A.

    2016-01-01

    Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neanderthals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neanderthal variants to over 1,000 electronic health record (EHR)-derived phenotypes in ~28,000 adults of European ancestry. We discovered and replicated associations of Neanderthal alleles with neurological, psychiatric, immunological, and dermatological phenotypes. Neanderthal alleles together explain a significant fraction of the variation in risk for depression and skin lesions resulting from sun exposure (actinic keratosis), and individual Neanderthal alleles are significantly associated with specific human phenotypes, including hypercoagulation and tobacco use. Our results establish that archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of hundreds of Neanderthal haplotypes and demonstrate the utility of EHR data in evolutionary analyses. PMID:26912863

  17. Admixture facilitates genetic adaptations to high altitude in Tibet

    PubMed Central

    Jeong, Choongwon; Alkorta-Aranburu, Gorka; Basnyat, Buddha; Neupane, Maniraj; Witonsky, David B.; Pritchard, Jonathan K.; Beall, Cynthia M.; Di Rienzo, Anna

    2015-01-01

    Admixture is recognized as a widespread feature of human populations, renewing interest in the possibility that genetic exchange can facilitate adaptations to new environments. Studies of Tibetans revealed candidates for high-altitude adaptations in the EGLN1 and EPAS1 genes, associated with lower hemoglobin concentration. However, the history of these variants or that of Tibetans remains poorly understood. Here, we analyze genotype data for the Nepalese Sherpa, and find that Tibetans are a mixture of ancestral populations related to the Sherpa and Han Chinese. EGLN1 and EPAS1 genes show a striking enrichment of high-altitude ancestry in the Tibetan genome, indicating that migrants from low altitude acquired adaptive alleles from the highlanders. Accordingly, the Sherpa and Tibetans share adaptive hemoglobin traits. This admixture-mediated adaptation shares important features with adaptive introgression. Therefore, we identify a novel mechanism, beyond selection on new mutations or on standing variation, through which populations can adapt to local environments. PMID:24513612

  18. Expedient Low-Temperature Concrete Admixtures for the Army

    DTIC Science & Technology

    1999-11-01

    admixture is to depress the freezing point of by weight of cement in reinforced concrete and is water. This function depends on a colligative not...recommended at all in pre-stressed concrete. property called molality-the number of parti- But, for expedient purposes where long-term cles (moles) that...the freezing point because, as noted, the benchmark, they nearly equaled the strengths the colligative behavior of chemicals can vary of control

  19. Adsorption of superplasticizer admixtures on alkali-activated slag pastes

    SciTech Connect

    Palacios, M. Houst, Y.F.; Bowen, P.; Puertas, F.

    2009-08-15

    Alkali-activated slag (AAS) binders are obtained by a manufacturing process less energy-intensive than ordinary Portland cement (OPC) and involves lower greenhouse gasses emission. These alkaline cements allow the production of high mechanical strength and durable concretes. In the present work, the adsorption of different superplasticizer admixtures (naphthalene-based, melamine-based and a vinyl copolymer) on the slag particles in AAS pastes using alkaline solutions with different pH values have been studied in detail. The effect of the superplasticizers on the yield stress and plastic viscosity of the AAS and OPC pastes have been also evaluated. The results obtained allowed us to conclude that the adsorption of the superplasticizers on AAS pastes is independent of the pH of the alkaline solutions used and lower than on OPC pastes. However, the effect of the admixtures on the rheological parameters depends directly on the type and dosage of the superplasticizer as well as of the binder used and, in the case of the AAS, on the pH of the alkaline activator solution. In 11.7-pH NaOH-AAS pastes the dosages of the superplasticizers required to attain similar reduction in the yield stress are ten-fold lower than for Portland cement. In this case the superplasticizers studied show a fluidizing effect considerably higher in 11.7-pH NaOH-AAS pastes than in OPC pastes. In 13.6-pH NaOH-AAS pastes, the only admixture observed to affect the rheological parameters is the naphthalene-based admixture due to its higher chemical stability in such extremely alkaline media.

  20. Complex History of Admixture between Modern Humans and Neandertals

    PubMed Central

    Vernot, Benjamin; Akey, Joshua M.

    2015-01-01

    Recent analyses have found that a substantial amount of the Neandertal genome persists in the genomes of contemporary non-African individuals. East Asians have, on average, higher levels of Neandertal ancestry than do Europeans, which might be due to differences in the efficiency of purifying selection, an additional pulse of introgression into East Asians, or other unexplored scenarios. To better define the scope of plausible models of archaic admixture between Neandertals and anatomically modern humans, we analyzed patterns of introgressed sequence in whole-genome data of 379 Europeans and 286 East Asians. We found that inferences of demographic history restricted to neutrally evolving genomic regions allowed a simple one-pulse model to be robustly rejected, suggesting that differences in selection cannot explain the differences in Neandertal ancestry. We show that two additional demographic models, involving either a second pulse of Neandertal gene flow into the ancestors of East Asians or a dilution of Neandertal lineages in Europeans by admixture with an unknown ancestral population, are consistent with the data. Thus, the history of admixture between modern humans and Neandertals is most likely more complex than previously thought. PMID:25683119

  1. Gender differences in ancestral contribution and admixture in Venezuelan populations.

    PubMed

    Guerra, D Castro De; Pérez, C Figuera; Izaguirre, M H; Barahona, E Arroyo; Larralde, A Rodríguez; Lugo, M Vívenes De

    2011-06-01

    The origin of the contribution of uniparental heritage were analyzed in 615 samples of individuals proceeding from 13 towns classified according to historic differences in their emergence and development as African-derived, European-derived, and admixed/urban. Mitochondrial and Y-chromosome haplogroups were identified by PCR-restriction fragment length polymorphism. The results were compared with previous estimates of admixture made with autosomal markers and with historic aspects. The results show a predominantly indigenous genetic contribution through the female, being more prevalent in urban populations; the African contribution, although dispersed, presents a larger concentration in the African-derived towns, whereas the European contribution is limited to populations with this origin, reflecting isolation and the conservation of the distribution pattern of genes of the Colonial era. With regard to admixture through males, it is almost exclusively of European origin, whereas the African contribution is basically concentrated in the African-derived towns, and the Amerindian lineages are almost nonexistent. The genome of paternal heredity, as opposed to the autosomal and the mitochondrial, shows a homogeneous pattern of admixture that is independent of the origin of the population studied, suggesting that European genes have been introduced into the Venezuelan population through male immigrations, whereas the indigenous contribution has been preserved in the Venezuelan genetic pool through the women. These results provide evidence of the heterogeneity in the genetic origin of the Venezuelan population, which should be taken into account in forensic and epidemiologic genetic studies.

  2. Experimental study of admixture on soil's physical and mechanical characteristics

    NASA Astrophysics Data System (ADS)

    Guo, Zihong; Li, Tangyong; Yu, Dongke; Tang, Hua; Zhang, Yang; Li, Zhaochen; He, Dan

    2017-08-01

    Earth building is a traditional architectural form. With respect to environment protection, low cost, convenient advantages, its practical value is recognizing carefully. Due to poor mechanical properties and durability of earth, the development of earth building has been prevented. This experiment selects two kinds of soil. Sawdust and straw serve as admixture. More than 300 specimens have been performed to verify the effects of various factors on soil's physical and mechanical characteristics. Some useful characteristics are acquired by the experiment, such as soil's optimal moisture content, maximum dry density, optimal length of straw and contraction ratio. Testing the influence of admixture on soil's strength and deformation, this experiment shows that mixing straw and sawdust reduce soil's compressive and tensile strength. However, it may reduce soil's contraction ratio. Considering the influence of admixture on soil's contraction and strength, when soil 1 mixes with 0.1% sawdust, its contraction ratio decreases obviously and strength decreases slightly. It is a good choice according to the experiments.

  3. Recent Admixture in an Indian Population of African Ancestry

    PubMed Central

    Narang, Ankita; Jha, Pankaj; Rawat, Vimal; Mukhopadhayay, Arijit; Dash, Debasis; Basu, Analabha; Mukerji, Mitali

    2011-01-01

    Identification and study of genetic variation in recently admixed populations not only provides insight into historical population events but also is a powerful approach for mapping disease loci. We studied a population (OG-W-IP) that is of African-Indian origin and has resided in the western part of India for 500 years; members of this population are believed to be descendants of the Bantu-speaking population of Africa. We have carried out this study by using a set of 18,534 autosomal markers common between Indian, CEPH-HGDP, and HapMap populations. Principal-components analysis clearly revealed that the African-Indian population derives its ancestry from Bantu-speaking west-African as well as Indo-European-speaking north and northwest Indian population(s). STRUCTURE and ADMIXTURE analyses show that, overall, the OG-W-IPs derive 58.7% of their genomic ancestry from their African past and have very little inter-individual ancestry variation (8.4%). The extent of linkage disequilibrium also reveals that the admixture event has been recent. Functional annotation of genes encompassing the ancestry-informative markers that are closer in allele frequency to the Indian ancestral population revealed significant enrichment of biological processes, such as ion-channel activity, and cadherins. We briefly examine the implications of determining the genetic diversity of this population, which could provide opportunities for studies involving admixture mapping. PMID:21737057

  4. Thermal properties of alkali-activated aluminosilicates with CNT admixture

    NASA Astrophysics Data System (ADS)

    Zmeskal, Oldrich; Trhlikova, Lucie; Fiala, Lukas; Florian, Pavel; Cerny, Robert

    2017-07-01

    Material properties of electrically conductive cement-based materials with increased attention paid on electric and thermal properties were often studied in the last years. Both electric and thermal properties play an important role thanks to their possible utilization in various practical applications (e.g. snow-melting systems or building structures monitoring systems without the need of an external monitoring system). The DC/AC characteristics depend significantly on the electrical resistivity and the electrical capacity of bulk materials. With respect to the DC/AC characteristics of cement-based materials, such materials can be basically classified as electric insulators. In order to enhance them, various conductive admixtures such as those based on different forms of carbon, can be used. Typical representatives of carbon-based admixtures are carbon nanotubes (CNT), carbon fibers (CF), graphite powder (GP) and carbon black (CB). With an adequate amount of such admixtures, electric properties significantly change and new materials with higher added value can be prepared. However, other types of materials can be enhanced in the same way. Alkali-activated aluminosilicates (AAA) based on blast furnace slag are materials with high compressive strength comparable with cement-based materials. Moreover, the price of slag is lower than of Portland cement. Therefore, this paper deals with the study of thermal properties of this promising material with different concentrations of CNT. Within the paper a simple method of basic thermal parameters determination based on the thermal transient response to a heat power step is presented.

  5. Extending Admixture Mapping to Nuclear Pedigrees: Application to Sarcoidosis

    PubMed Central

    McKeigue, Paul M.; Colombo, Marco; Agakov, Felix; Datta, Indrani; Levin, Albert; Favro, David; Gray-Montgomery, Courtney; Iannuzzi, Michael C.; Rybicki, Benjamin A.

    2013-01-01

    We describe statistical methods that extend the application of admixture mapping from unrelated individuals to nuclear pedigrees, allowing existing pedigree-based collections to be fully exploited. Computational challenges have been overcome by developing a fast algorithm that exploits the factorial structure of the underlying model of ancestry transitions. This has been implemented as an extension of the program ADMIXMAP. We demonstrate the application of the method to a study of sarcoidosis in African Americans that has previously been analyzed only as an admixture mapping study restricted to unrelated individuals. Although the ancestry signals detected in this pedigree analysis are generally similar to those detected in the earlier analysis of unrelated cases, we are able to extract more information and this yields a much sharper exclusion map; using the classical criterion of an LOD score of minus 2, the pedigree analysis is able to exclude a risk ratio of 2 or more associated with African ancestry over 96% of the genome, compared with only 83% in the earlier analysis of unrelated individuals only. Although the pedigree extension of ADMIXMAP can use ancestry-informative markers only at relatively low density, it can use imputed ancestry states from programs such as WINPOP or HAPMIX that use dense SNP marker genotypes for admixture mapping. This extends both the efficiency and the range of application of this powerful gene mapping method. PMID:23371909

  6. Admixture mapping identifies introgressed genomic regions in North American canids.

    PubMed

    vonHoldt, Bridgett M; Kays, Roland; Pollinger, John P; Wayne, Robert K

    2016-06-01

    Hybrid zones typically contain novel gene combinations that can be tested by natural selection in a unique genetic context. Parental haplotypes that increase fitness can introgress beyond the hybrid zone, into the range of parental species. We used the Affymetrix canine SNP genotyping array to identify genomic regions tagged by multiple ancestry informative markers that are more frequent in an admixed population than expected. We surveyed a hybrid zone formed in the last 100 years as coyotes expanded their range into eastern North America. Concomitant with expansion, coyotes hybridized with wolves and some populations became more wolflike, such that coyotes in the northeast have the largest body size of any coyote population. Using a set of 3102 ancestry informative markers, we identified 60 differentially introgressed regions in 44 canines across this admixture zone. These regions are characterized by an excess of exogenous ancestry and, in northeastern coyotes, are enriched for genes affecting body size and skeletal proportions. Further, introgressed wolf-derived alleles have penetrated into Southern US coyote populations. Because no wolves currently exist in this area, these alleles are unlikely to have originated from recent hybridization. Instead, they probably originated from intraspecific gene flow or ancient admixture. We show that grey wolf and coyote admixture has far-reaching effects and, in addition to phenotypically transforming admixed populations, allows for the differential movement of alleles from different parental species to be tested in new genomic backgrounds.

  7. The Impact of Rhythmic Entrainment on a Person with Autism.

    ERIC Educational Resources Information Center

    Orr, Tracy Jo; Myles, Brenda Smith; Carlson, Judith K.

    1998-01-01

    A study investigated the impact of rhythmic entrainment on an 11-year-old girl with autism who engaged in head jerking and screaming. Rhythmic entrainment intervention was more effective when she exhibited behavior that resulted from a moderate level of stress and less effective when stressors were more severe. (CR)

  8. Entrainment of circadian rhythm by ambient temperature cycles in mice.

    PubMed

    Refinetti, Roberto

    2010-08-01

    Much is known about how environmental light-dark cycles synchronize circadian rhythms in animals. The ability of environmental cycles of ambient temperature to synchronize circadian rhythms has also been investigated extensively but mostly in ectotherms. In the present study, the synchronization of the circadian rhythm of running-wheel activity by environmental cycles of ambient temperature was studied in laboratory mice. Although all mice were successfully entrained by a light-dark cycle, only 60% to 80% of the mice were entrained by temperature cycles (24-32 degrees C or 24-12 degrees C), and attainment of stable entrainment seemed to take longer under temperature cycles than under a light-dark cycle. This suggests that ambient temperature cycles are weaker zeitgebers than light-dark cycles, which is consistent with the results of the few previous studies using mammalian species. Whereas 80% of the mice were entrained by 24-h temperature cycles, only 60% were entrained by 23-h cycles, and none was entrained by 25-h cycles. The results did not clarify whether entrainment by temperature cycles is caused directly by temperature or indirectly through a temperature effect on locomotor activity, but it is clear that the rhythm of running-wheel activity in mice can be entrained by ambient temperature cycles in the nonnoxious range.

  9. No Time To Kill: Entrainment and Accelerating Courseware Development.

    ERIC Educational Resources Information Center

    Millington, Paula Crnkovich

    This paper examines the concept of time in multimedia, World Wide Web-based courseware development. The biological concept of entrainment (the alignment of rhythms within and between systems) to accelerate courseware development is explored. The discussion begins with the foundational concepts of entrainment from biological systems and social…

  10. Modeling of neutral entrainment in an FRC thruster

    SciTech Connect

    Brackbill, Jeremiah; Gimelshein, Natalia; Gimelshein, Sergey; Cambier, Jean-Luc; Ketsdever, Andrew

    2012-11-27

    Neutral entrainment in a field reversed configuration thruster is modeled numerically with an implicit PIC code extended to include thermal and chemical interactions between plasma and neutral particles. The contribution of charge exchange and electron impact ionization reactions is analyzed, and the sensitivity of the entrainment efficiency to the plasmoid translation velocity and neutral density is evaluated.

  11. Can cloud-top entrainment promote cloud growth?

    NASA Technical Reports Server (NTRS)

    Randall, D. A.

    1984-01-01

    The primary significance of Cloud Deepening through Entrainment (CDE) is that it can prevent the cloud top entrainment instability from destroying a cloud deck. Without suppressing the instability, CDE transforms it from a cloud destroyer to a cloud builder. The analysis does not depend on an entrainment hypothesis. Moreover, it is not restricted to PBL stratocumulus sheets. Stratiform clouds in the free atmosphere can be subject to CDE we need only reinterpret Ps as the pressure at the base of an elevated turbulent mixed layer. Modest departures from well mixedness will alter the results quantitatively but not qualitatively. Processes other than entrainment, such as surface evaporation, radiative cooling, and advection will often work with CDE to build a cloud layer; but of course they can also oppose CDE by reducing the relative humidity. If we make the weak assumption that the deepening of a cloud layer favors an increase in the cloud top entrainment rate (without specifying any particular functional relationship) we are led to speculate that CDE can cause runaway cloud growth, even in the absence of cloud top entrainment instability. through CDE entrainment leads to a deeper cloud, which leads to stronger entrainment.

  12. Rhythm as a Coordinating Device: Entrainment with Disordered Speech

    ERIC Educational Resources Information Center

    Borrie, Stephanie A.; Liss, Julie M.

    2014-01-01

    Purpose: The rhythmic entrainment (coordination) of behavior during human interaction is a powerful phenomenon, considered essential for successful communication, supporting social and emotional connection, and facilitating sense-making and information exchange. Disruption in entrainment likely occurs in conversations involving those with speech…

  13. Cohesive Sediment Entrainment Rate Functions: Expanding and Quantifying their Parameterizations

    DTIC Science & Technology

    2008-04-03

    biostabilization on entrainment (de Brouwer et al., 2000; Droppo et al. 2001). The LISP project (Littoral Investigation of Sediment Properties) (Daborn...and exponential entrainment rate functions was performed in order to demonstrate the necessity for physics based parameterization schemes . It was

  14. The Impact of Rhythmic Entrainment on a Person with Autism.

    ERIC Educational Resources Information Center

    Orr, Tracy Jo; Myles, Brenda Smith; Carlson, Judith K.

    1998-01-01

    A study investigated the impact of rhythmic entrainment on an 11-year-old girl with autism who engaged in head jerking and screaming. Rhythmic entrainment intervention was more effective when she exhibited behavior that resulted from a moderate level of stress and less effective when stressors were more severe. (CR)

  15. Macroscopic entrainment of periodically forced oscillatory ensembles.

    PubMed

    Popovych, Oleksandr V; Tass, Peter A

    2011-03-01

    Large-amplitude oscillations of macroscopic neuronal signals, such as local field potentials and electroencephalography or magnetoencephalography signals, are commonly considered as being generated by a population of mutually synchronized neurons. In a computational study in generic networks of phase oscillators and bursting neurons, however, we show that this common belief may be wrong if the neuronal population receives an external rhythmic input. The latter may stem from another neuronal population or an external, e.g., sensory or electrical, source. In that case the population field potential may be entrained by the rhythmic input, whereas the individual neurons are phase desynchronized both mutually and with their field potential. Intriguingly, the corresponding large-amplitude oscillations of the population mean field are generated by pairwise desynchronized neurons oscillating at frequencies shifted far away from the frequency of the macroscopic field potential.

  16. Mutual entrainment of bilaterally distributed circadian pacemaker.

    PubMed

    Page, T L; Caldarola, P C; Pittendrigh, C S

    1977-03-01

    The interactions between the bilaterally distributed components of the circadin system that controls the locomotor activity rhythm of the cockroach Leucophaea maderae were investigated in a series of surgical lesion experiments. Complete excision of one optic lobe (either right or left) or its surgical isolation from the central nervous system had no effect on the animals' ability to free-run in constant darkness nor was there any indication, as judged by postoperative pi values of any difference between left and right lobe pacemakers. However, these surgical procedures consistently resulted in a significant increase in tau over preoperative value while optic nerve section had no effect on tau. The propostion is developed that the left and right pacemakers in the two optic lobes are mutally coupled and that the compound pacemaker's period is shorter than either of its constituent pacemakers. It was also found that the integrity of either compound eye is sufficient to assure entrainment of both left and right pacemakers.

  17. Entrainment of neural oscillations as a modifiable substrate of attention.

    PubMed

    Calderone, Daniel J; Lakatos, Peter; Butler, Pamela D; Castellanos, F Xavier

    2014-06-01

    Brain operation is profoundly rhythmic. Oscillations of neural excitability shape sensory, motor, and cognitive processes. Intrinsic oscillations also entrain to external rhythms, allowing the brain to optimize the processing of predictable events such as speech. Moreover, selective attention to a particular rhythm in a complex environment entails entrainment of neural oscillations to its temporal structure. Entrainment appears to form one of the core mechanisms of selective attention, which is likely to be relevant to certain psychiatric disorders. Deficient entrainment has been found in schizophrenia and dyslexia and mounting evidence also suggests that it may be abnormal in attention-deficit/hyperactivity disorder (ADHD). Accordingly, we suggest that studying entrainment in selective-attention paradigms is likely to reveal mechanisms underlying deficits across multiple disorders.

  18. A New Approach for Estimating Entrainment Rate in Cumulus Clouds

    SciTech Connect

    Lu C.; Liu, Y.; Yum, S. S.; Niu, S.; Endo, S.

    2012-02-16

    A new approach is presented to estimate entrainment rate in cumulus clouds. The new approach is directly derived from the definition of fractional entrainment rate and relates it to mixing fraction and the height above cloud base. The results derived from the new approach compare favorably with those obtained with a commonly used approach, and have smaller uncertainty. This new approach has several advantages: it eliminates the need for in-cloud measurements of temperature and water vapor content, which are often problematic in current aircraft observations; it has the potential for straightforwardly connecting the estimation of entrainment rate and the microphysical effects of entrainment-mixing processes; it also has the potential for developing a remote sensing technique to infer entrainment rate.

  19. Entrainment Zone Characteristics and Entrainment Rates in Cloud-Topped Boundary Layers from DYCOMS-II

    DTIC Science & Technology

    2012-03-01

    7  Figure 4.  Mean thermodynamic structure as observed in the subtropical northeast Pacific Ocean in 2001. Total water, liquid water and...cloud-top entrainment zones. Furthermore, DMS is sourced at the oceanic surface and nearly non-existent in the free- atmosphere, thereby accurately...the atmospheric battlespace environment. Game theory suggests that friendly U.S. forces must strategically utilize atmospheric conditions and

  20. Ground-Based Remote Retrievals of Cumulus Entrainment Rates

    SciTech Connect

    Wagner, Timothy J.; Turner, David D.; Berg, Larry K.; Krueger, Steven K.

    2013-07-26

    While fractional entrainment rates for cumulus clouds have typically been derived from airborne observations, this limits the size and scope of available data sets. To increase the number of continental cumulus entrainment rate observations available for study, an algorithm for retrieving them from ground-based remote sensing observations has been developed. This algorithm, called the Entrainment Rate In Cumulus Algorithm (ERICA), uses the suite of instruments at the Southern Great Plains (SGP) site of the United States Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility as inputs into a Gauss-Newton optimal estimation scheme, in which an assumed guess of the entrainment rate is iteratively adjusted through intercomparison of modeled liquid water path and cloud droplet effective radius to their observed counterparts. The forward model in this algorithm is the Explicit Mixing Parcel Model (EMPM), a cloud parcel model that treats entrainment as a series of discrete entrainment events. A quantified value for measurement uncertainty is also returned as part of the retrieval. Sensitivity testing and information content analysis demonstrate the robust nature of this method for retrieving accurate observations of the entrainment rate without the drawbacks of airborne sampling. Results from a test of ERICA on three months of shallow cumulus cloud events show significant variability of the entrainment rate of clouds in a single day and from one day to the next. The mean value of 1.06 km-¹ for the entrainment rate in this dataset corresponds well with prior observations and simulations of the entrainment rate in cumulus clouds.

  1. Forecasting Inundation from Debris Flows That Grow By Entraining Sediment

    NASA Astrophysics Data System (ADS)

    Reid, M. E.; Coe, J. A.; Brien, D. L.

    2014-12-01

    Destructive debris flows often grow, and extend their runouts, by entraining sediment as they travel. However, incorporating varied entrainment processes into physics-based flow routing models is challenging. As an alternative, we developed a relatively simple, automated method for forecasting the inundation hazards posed by debris flows that entrain sediment and coalesce from multiple flows. Within a drainage network, we amalgamate the effects of many possible debris flows with each flow volume proportional to an entrainment rate scaled by the upslope contributing area, and then use these volumes in the USGS GIS-based inundation model LAHARZ. Our approach only requires estimates of two parameters: spatial entrainment rate & maximum entrainment area or maximum volume. Our procedure readily integrates various sediment sources and it can portray different inundation hazard levels on a GIS-based map by varying our two parameters. We applied this approach to part of the Coast Range, southern Oregon, USA. Using aerial photography, we mapped debris flows triggered by a large 1996 rain event on a LiDAR-derived topographic base, and identified initiation locations, travel paths, and areas of channel erosion and deposition. Many catchments experienced multiple debris flows that coalesced downstream and about 95% of the debris flows entrained sediment as they traveled. Flows typically stopped entraining sediment before the upslope contributing area reached ~500,000 m2. We used pre- and post-debris-flow stereo photos to estimate spatial entrainment rates in four clear-cut catchments having both channel erosion and coalescence of flows; these rates varied from 0.12 to 0.2 m3/m2. GIS-based inundation maps, using our automated methods, are quite similar to the mapped flow paths and deposits. Given appropriate parameters, our approach could be applied to a variety of steep, channelized environments where entrainment is important, such as alpine and post-wildfire slopes.

  2. How important is intraspecific genetic admixture to the success of colonising populations?

    PubMed

    Rius, Marc; Darling, John A

    2014-04-01

    Genetic admixture of divergent intraspecific lineages is increasingly suspected to have an important role in the success of colonising populations. However, admixture is not a universally beneficial genetic phenomenon. Selection is typically expected to favour locally adapted genotypes and can act against admixed individuals, suggesting that there are some conditions under which admixture will have negative impacts on population fitness. Therefore, it remains unclear how often admixture acts as a true driver of colonisation success. Here, we review the population consequences of admixture and discuss its costs and benefits across a broad spectrum of ecological contexts. We critically evaluate the evidence for a causal role of admixture in successful colonisation, and consider that role more generally in driving population range expansion. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Aeolian entrainment of sediment from an aerodynamically rough bed surface

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Xiao-Hu, Zhao; Zhen Shan, Li

    2017-04-01

    Particle entrainment due to air at low mobility conditions is important in a range of processes relevant to applied research themes ranging from aeolian sediment transport mechanics to particle technology (e.g. pneumatic transport). Until recently, challenges in accurately measuring particle displacement have hindered progress in identifying the relevant mechanisms responsible for this. In this study, the design of appropriate particle transport experiments in a wind tunnel and measurements of angular displacement of an exposed particle resting on a flat, aerodynamically roughened bed surface. Specifically, the minute displacements (rocking) to full dislodgement events (rolling) of the particle are detected by a high resolution laser distance sensor (LDS). Displacement statistics based on parameters such as variation, frequency, duration, amplitude, time between displacements are investigated and discussed. These results suggest that rocking and rolling of particles can be separated by an angular threshold. Following this statistical framework to establish such a threshold parameter for a wider range of particle features is useful for the determination of the conditions under which transport at low mobility rates occurs.

  4. Characteristics of rice husk gasification in an entrained flow reactor.

    PubMed

    Zhao, Yijun; Sun, Shaozeng; Tian, Hongming; Qian, Juan; Su, Fengming; Ling, Feng

    2009-12-01

    Experiments were performed in an entrained flow reactor to better understand the characteristics of biomass gasification. Rice husk was used in this study. Effects of the gasification temperature (700, 800, 900 and 1000 degrees C) and the equivalence ratio in the range of 0.22-0.34 on the biomass gasification and the axial gas distribution in the reactor were studied. The results showed that reactions of CnHm were less important in the gasification process except cracking reactions which occurred at higher temperature. In the oxidization zone, reactions between char and oxygen had a more prevailing role. The optimal gasification temperature of the rice husk could be above 900 degrees C, and the optimal value of ER was 0.25. The gasification process was finished in 1.42 s when the gasification temperature was above 800 degrees C. A first order kinetic model was developed for describing rice husk air gasification characteristics and the relevant kinetic parameters were determined.

  5. Percentage entrainment of constituent loads in urban runoff, south Florida

    USGS Publications Warehouse

    Miller, R.A.

    1985-01-01

    Runoff quantity and quality data from four urban basins in south Florida were analyzed to determine the entrainment of total nitrogen, total phosphorus, total carbon, chemical oxygen demand, suspended solids, and total lead within the stormwater runoff. Land use of the homogeneously developed basins are residential (single family), highway, commercial, and apartment (multifamily). A computational procedure was used to calculate, for all storms that had water-quality data, the percentage of constituent load entrainment in specified depths of runoff. The plot of percentage of constituent load entrained as a function of runoff is termed the percentage-entrainment curve. Percentage-entrainment curves were developed for three different source areas of basin runoff: (1) the hydraulically effective impervious area, (2) the contributing area, and (3) the drainage area. With basin runoff expressed in inches over the contributing area, the depth of runoff required to remove 90 percent of the constituent load ranged from about 0.4 inch to about 1.4 inches; and to remove 80 percent, from about 0.3 to 0.9 inch. Analysis of variance, using depth of runoff from the contributing area as the response variable, showed that the factor 'basin' is statistically significant, but that the factor 'constituent' is not statistically significant in the forming of the percentage-entrainment curve. Evidently the sewerage design, whether elongated or concise in plan dictates the shape of the percentage-entrainment curve. The percentage-entrainment curves for all constituents were averaged for each basin and plotted against basin runoff for three source areas of runoff-the hydraulically effective impervious area, the contributing area, and the drainage area. The relative positions of the three curves are directly related to the relative sizes of the three source areas considered. One general percentage-entrainment curve based on runoff from the contributing area was formed by averaging across

  6. Relationship between Adiposity and Admixture in African American and Hispanic American Women

    PubMed Central

    Nassir, Rami; Qi, Lihong; Kosoy, Roman; Garcia, Lorena; Allison, Matthew; Ochs– Balcom, Heather M.; Tylavsky, Fran; Manson, JoAnn E.; Shigeta, Russell; Robbins, John; Seldin, Michael F.

    2011-01-01

    Objective To investigate whether differences in admixture in African American (AFA) and Hispanic American (HA) adult women are associated with adiposity and adipose distribution. Design The proportion of European, sub– Saharan African and Amerindian admixture was estimated for AFA and HA women in the Women's Heath Initiative using 92 ancestry informative markers. Analyses assessed the relationship between admixture and adiposity indices. Subjects 11712 AFA and 5088 HA self– identified post– menopausal women. Results There was a significant positive association between body mass index (BMI) and African admixture when BMI was considered as a continuous variable, and age, education, physical activity, parity, family income and smoking were included covariates (p < 10− 4). A dichotomous model (upper and lower BMI quartiles) showed that African admixture was associated with a high odds ratio [OR = 3.27 (for 100% admixture compared to 0% admixture), 95% confidence interval (CI) 2.08 – 5.15]. For HA there was no association between BMI and admixture. In contrast, when waist to hip ratio (WHR) was used as a measure of adipose distribution, there was no significant association between WHR and admixture in AFA but there was a strong association in HA (p<10− 4; OR Amerindian admixture = 5.93, CI = 3.52 – 9.97). Conclusion These studies show that 1) African admixture is associated with BMI in AFA women; 2) Amerindian admixture is associated with WHR but not BMI in HA women; and 3) it may be important to consider different measurements of adiposity and adipose distribution in different ethnic population groups. PMID:21487399

  7. Tropical deep convection, entrainment, and dilution during the dynamo field campaign

    NASA Astrophysics Data System (ADS)

    Hannah, Walter

    more humid environment is better explained by a reduction of buoyancy dilution. An additional sensitivity experiment shows that entrainment and dilution are enhanced when convection is organized by the presence of vertical wind shear. The enhanced dilution is associated with entrainment of drier air on average. (Abstract shortened by UMI.).

  8. Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10

    PubMed Central

    Mühlebach, S.; Franken, C.; Stanga, Z.

    2009-01-01

    All-in-one admixtures (AIO-admixtures) provide safe, effective and low-risk PN (parenteral nutrition) for practically all indications and applications. Water, energy (carbohydrates and lipids), amino acids, vitamins and trace elements are infused together with PN either as industrially-manufactured AIO admixtures provided as two- or three-chamber bags (shelf life usually more than 12 months) completed with electrolytes and micronutrients where appropriate or as individually compounded ready-to-use AIO admixtures (compounding, usually prepared by a pharmacy on either a daily or weekly basis and stored at 2–8°C). Physico-chemical and microbial stability of an AIO admixture is essential for the safety and effectiveness of patient-specific PN, and its assurance requires specialist pharmaceutical knowledge. The stability should be documented for an application period of 24 (–48) hours. It is advisable to offer a limited selection of different PN regimes in each hospital. For reasons of drug and medication safety, PN admixtures prepared for individual patients must be correctly labelled and specifications for storage conditions must also be followed during transport. Monitoring is required where applicable. Micronutrients are usually administered separately to AIO admixtures. In case compatibility and stability have been well documented trace elements and/or combination preparations including water-soluble or water-soluble/fat soluble vitamin supplements can be added to PN admixtures under strict aseptic conditions. AIO admixtures are usually not used as vehicles for drugs (incompatibilities). PMID:20049073

  9. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function

    PubMed Central

    Jiang, Heidi; Zhou, Guangyu; Arora, Nikita; Schuele, Stephan; Rosenow, Joshua; Gottfried, Jay A.

    2016-01-01

    The need to breathe links the mammalian olfactory system inextricably to the respiratory rhythms that draw air through the nose. In rodents and other small animals, slow oscillations of local field potential activity are driven at the rate of breathing (∼2–12 Hz) in olfactory bulb and cortex, and faster oscillatory bursts are coupled to specific phases of the respiratory cycle. These dynamic rhythms are thought to regulate cortical excitability and coordinate network interactions, helping to shape olfactory coding, memory, and behavior. However, while respiratory oscillations are a ubiquitous hallmark of olfactory system function in animals, direct evidence for such patterns is lacking in humans. In this study, we acquired intracranial EEG data from rare patients (Ps) with medically refractory epilepsy, enabling us to test the hypothesis that cortical oscillatory activity would be entrained to the human respiratory cycle, albeit at the much slower rhythm of ∼0.16–0.33 Hz. Our results reveal that natural breathing synchronizes electrical activity in human piriform (olfactory) cortex, as well as in limbic-related brain areas, including amygdala and hippocampus. Notably, oscillatory power peaked during inspiration and dissipated when breathing was diverted from nose to mouth. Parallel behavioral experiments showed that breathing phase enhances fear discrimination and memory retrieval. Our findings provide a unique framework for understanding the pivotal role of nasal breathing in coordinating neuronal oscillations to support stimulus processing and behavior. SIGNIFICANCE STATEMENT Animal studies have long shown that olfactory oscillatory activity emerges in line with the natural rhythm of breathing, even in the absence of an odor stimulus. Whether the breathing cycle induces cortical oscillations in the human brain is poorly understood. In this study, we collected intracranial EEG data from rare patients with medically intractable epilepsy, and found evidence

  10. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function.

    PubMed

    Zelano, Christina; Jiang, Heidi; Zhou, Guangyu; Arora, Nikita; Schuele, Stephan; Rosenow, Joshua; Gottfried, Jay A

    2016-12-07

    The need to breathe links the mammalian olfactory system inextricably to the respiratory rhythms that draw air through the nose. In rodents and other small animals, slow oscillations of local field potential activity are driven at the rate of breathing (∼2-12 Hz) in olfactory bulb and cortex, and faster oscillatory bursts are coupled to specific phases of the respiratory cycle. These dynamic rhythms are thought to regulate cortical excitability and coordinate network interactions, helping to shape olfactory coding, memory, and behavior. However, while respiratory oscillations are a ubiquitous hallmark of olfactory system function in animals, direct evidence for such patterns is lacking in humans. In this study, we acquired intracranial EEG data from rare patients (Ps) with medically refractory epilepsy, enabling us to test the hypothesis that cortical oscillatory activity would be entrained to the human respiratory cycle, albeit at the much slower rhythm of ∼0.16-0.33 Hz. Our results reveal that natural breathing synchronizes electrical activity in human piriform (olfactory) cortex, as well as in limbic-related brain areas, including amygdala and hippocampus. Notably, oscillatory power peaked during inspiration and dissipated when breathing was diverted from nose to mouth. Parallel behavioral experiments showed that breathing phase enhances fear discrimination and memory retrieval. Our findings provide a unique framework for understanding the pivotal role of nasal breathing in coordinating neuronal oscillations to support stimulus processing and behavior. Animal studies have long shown that olfactory oscillatory activity emerges in line with the natural rhythm of breathing, even in the absence of an odor stimulus. Whether the breathing cycle induces cortical oscillations in the human brain is poorly understood. In this study, we collected intracranial EEG data from rare patients with medically intractable epilepsy, and found evidence for respiratory entrainment

  11. A Balanced Diet Is Necessary for Proper Entrainment Signals of the Mouse Liver Clock

    PubMed Central

    Hirao, Akiko; Tahara, Yu; Kimura, Ichiro; Shibata, Shigenobu

    2009-01-01

    Background The peripheral circadian clock in mice is entrained not only by light-dark cycles but also by daily restricted feeding schedules. Behavioral and cell culture experiments suggest an increase in glucose level as a factor in such feeding-induced entrainment. For application of feeding-induced entrainment in humans, nutrient content and dietary variations should be considered. Principal Finding To elucidate the food composition necessary for dietary entrainment, we examined whether complete or partial substitution of dietary nutrients affected phase shifts in liver clocks of mice. Compared with fasting mice or ad libitum fed mice, the liver bioluminescence rhythm advanced by 3–4 h on the middle day in Per2::luciferase knock-in mice that were administered a standard mouse diet, i.e. AIN-93M formula [0.6–0.85 g/10 g mouse BW] (composition: 14% casein, 47% cornstarch, 15% gelatinized cornstarch, 10% sugar, 4% soybean oil, and 10% other [fiber, vitamins, minerals, etc.]), for 2 days. When each nutrient was tested alone (100% nutrient), an insignificant weak phase advance was found to be induced by cornstarch and soybean oil, but almost no phase advance was induced by gelatinized cornstarch, high-amylose cornstarch, glucose, sucrose, or casein. A combination of glucose and casein without oil, vitamin, or fiber caused a significant phase advance. When cornstarch in AIN-93M was substituted with glucose, sucrose, fructose, polydextrose, high-amylose cornstarch, or gelatinized cornstarch, the amplitude of phase advance paralleled the increase in blood glucose concentration. Conclusions Our results strongly suggest the following: (1) balanced diets containing carbohydrates/sugars and proteins are good for restricted feeding-induced entrainment of the peripheral circadian clock and (2) a balanced diet that increases blood glucose, but not by sugar alone, is suitable for entrainment. These findings may assist in the development of dietary recommendations for on

  12. Cortical entrainment to music and its modulation by expertise

    PubMed Central

    Doelling, Keith B.; Poeppel, David

    2015-01-01

    Recent studies establish that cortical oscillations track naturalistic speech in a remarkably faithful way. Here, we test whether such neural activity, particularly low-frequency (<8 Hz; delta–theta) oscillations, similarly entrain to music and whether experience modifies such a cortical phenomenon. Music of varying tempi was used to test entrainment at different rates. In three magnetoencephalography experiments, we recorded from nonmusicians, as well as musicians with varying years of experience. Recordings from nonmusicians demonstrate cortical entrainment that tracks musical stimuli over a typical range of tempi, but not at tempi below 1 note per second. Importantly, the observed entrainment correlates with performance on a concurrent pitch-related behavioral task. In contrast, the data from musicians show that entrainment is enhanced by years of musical training, at all presented tempi. This suggests a bidirectional relationship between behavior and cortical entrainment, a phenomenon that has not previously been reported. Additional analyses focus on responses in the beta range (∼15–30 Hz)—often linked to delta activity in the context of temporal predictions. Our findings provide evidence that the role of beta in temporal predictions scales to the complex hierarchical rhythms in natural music and enhances processing of musical content. This study builds on important findings on brainstem plasticity and represents a compelling demonstration that cortical neural entrainment is tightly coupled to both musical training and task performance, further supporting a role for cortical oscillatory activity in music perception and cognition. PMID:26504238

  13. Nonphotic entrainment of activity and temperature rhythms in anophthalmic mice.

    PubMed

    Laemle, L K; Ottenweller, J E

    1999-05-01

    Although it is more common to study the effects of light on circadian systems, nonphotic stimuli can also influence and entrain circadian clocks. Because anophthalmic mice (ZRDCT-AN) have a genetic mutation that prevents the development of the eyes, they do not respond to light or entrain to light-dark cycles. Thus, entrainment of anophthalmic mice requires a nonphotic zeitgeber (entraining stimulus). In the current study we attempted to entrain sighted and anophthalmic mice of the same strain, using restricted access to an unlocked running wheel as the zeitgeber. First, free-running rhythms were established. The running wheels were then locked, and unlocked only from 0930-1130 h each day. Finally, a postentrainment free run was measured. In one group of animals, body temperature and general activity were measured using a Minimitter telemetry system. In another, general activity was measured by a sensitive force plate beneath the cage. Running-wheel activity was recorded in both groups. The force plate proved satisfactory for observing the behavior of the circadian system during wheel locking, and preferable to the temperature transmitters for long-term studies because the battery life of the mouse temperature transmitters was limited. Both sighted and anophthalmic mice were able to entrain to restricted wheel access, although not all animals responded. Mice that did not entrain showed either no effect of wheel locking or exhibited masking.

  14. Cortical entrainment to music and its modulation by expertise.

    PubMed

    Doelling, Keith B; Poeppel, David

    2015-11-10

    Recent studies establish that cortical oscillations track naturalistic speech in a remarkably faithful way. Here, we test whether such neural activity, particularly low-frequency (<8 Hz; delta-theta) oscillations, similarly entrain to music and whether experience modifies such a cortical phenomenon. Music of varying tempi was used to test entrainment at different rates. In three magnetoencephalography experiments, we recorded from nonmusicians, as well as musicians with varying years of experience. Recordings from nonmusicians demonstrate cortical entrainment that tracks musical stimuli over a typical range of tempi, but not at tempi below 1 note per second. Importantly, the observed entrainment correlates with performance on a concurrent pitch-related behavioral task. In contrast, the data from musicians show that entrainment is enhanced by years of musical training, at all presented tempi. This suggests a bidirectional relationship between behavior and cortical entrainment, a phenomenon that has not previously been reported. Additional analyses focus on responses in the beta range (∼15-30 Hz)-often linked to delta activity in the context of temporal predictions. Our findings provide evidence that the role of beta in temporal predictions scales to the complex hierarchical rhythms in natural music and enhances processing of musical content. This study builds on important findings on brainstem plasticity and represents a compelling demonstration that cortical neural entrainment is tightly coupled to both musical training and task performance, further supporting a role for cortical oscillatory activity in music perception and cognition.

  15. Complex Patterns of Genomic Admixture within Southern Africa

    PubMed Central

    Petersen, Desiree C.; Libiger, Ondrej; Tindall, Elizabeth A.; Hardie, Rae-Anne; Hannick, Linda I.; Glashoff, Richard H.; Mukerji, Mitali; Fernandez, Pedro; Haacke, Wilfrid; Schork, Nicholas J.; Hayes, Vanessa M.

    2013-01-01

    Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the click-speaking forager peoples of southern Africa, broadly defined as Khoesan. Both intra- (Bantu expansion) and inter-continental migration (European-driven colonization) have resulted in complex patterns of admixture between ancient geographically isolated Khoesan and more recently diverged populations. Using gender-specific analysis and almost 1 million autosomal markers, we determine the significance of estimated ancestral contributions that have shaped five contemporary southern African populations in a cohort of 103 individuals. Limited by lack of available data for homogenous Khoesan representation, we identify the Ju/'hoan (n = 19) as a distinct early diverging human lineage with little to no significant non-Khoesan contribution. In contrast to the Ju/'hoan, we identify ancient signatures of Khoesan and Bantu unions resulting in significant Khoesan- and Bantu-derived contributions to the Southern Bantu amaXhosa (n = 15) and Khoesan !Xun (n = 14), respectively. Our data further suggests that contemporary !Xun represent distinct Khoesan prehistories. Khoesan assimilation with European settlement at the most southern tip of Africa resulted in significant ancestral Khoesan contributions to the Coloured (n = 25) and Baster (n = 30) populations. The latter populations were further impacted by 170 years of East Indian slave trade and intra-continental migrations resulting in a complex pattern of genetic variation (admixture). The populations of southern Africa provide a unique opportunity to investigate the genomic variability from some of the oldest human lineages to the implications of complex admixture patterns including ancient and recently diverged human lineages. PMID:23516368

  16. Complex patterns of genomic admixture within southern Africa.

    PubMed

    Petersen, Desiree C; Libiger, Ondrej; Tindall, Elizabeth A; Hardie, Rae-Anne; Hannick, Linda I; Glashoff, Richard H; Mukerji, Mitali; Fernandez, Pedro; Haacke, Wilfrid; Schork, Nicholas J; Hayes, Vanessa M

    2013-01-01

    Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the click-speaking forager peoples of southern Africa, broadly defined as Khoesan. Both intra- (Bantu expansion) and inter-continental migration (European-driven colonization) have resulted in complex patterns of admixture between ancient geographically isolated Khoesan and more recently diverged populations. Using gender-specific analysis and almost 1 million autosomal markers, we determine the significance of estimated ancestral contributions that have shaped five contemporary southern African populations in a cohort of 103 individuals. Limited by lack of available data for homogenous Khoesan representation, we identify the Ju/'hoan (n = 19) as a distinct early diverging human lineage with little to no significant non-Khoesan contribution. In contrast to the Ju/'hoan, we identify ancient signatures of Khoesan and Bantu unions resulting in significant Khoesan- and Bantu-derived contributions to the Southern Bantu amaXhosa (n = 15) and Khoesan !Xun (n = 14), respectively. Our data further suggests that contemporary !Xun represent distinct Khoesan prehistories. Khoesan assimilation with European settlement at the most southern tip of Africa resulted in significant ancestral Khoesan contributions to the Coloured (n = 25) and Baster (n = 30) populations. The latter populations were further impacted by 170 years of East Indian slave trade and intra-continental migrations resulting in a complex pattern of genetic variation (admixture). The populations of southern Africa provide a unique opportunity to investigate the genomic variability from some of the oldest human lineages to the implications of complex admixture patterns including ancient and recently diverged human lineages.

  17. Whistler Solitons in Plasma with Anisotropic Hot Electron Admixture

    NASA Technical Reports Server (NTRS)

    Khazanov, G. V.; Krivorutsky, E. N.; Gallagher, D. L.

    1999-01-01

    The longitudinal and transverse modulation instability of whistler waves in plasma, with a small admixture of hot anisotropic electrons, is discussed. If the hot particles temperature anisotropy is positive, it is found that, in such plasma, longitudinal perturbations can lead to soliton formation for frequencies forbidden in cold plasma. The soliton is enriched by hot particles. The frequency region unstable to transverse modulation in cold plasma in the presence of hot electrons is divided by stable domains. For both cases the role of hot electrons is more significant for whistlers with smaller frequencies.

  18. Activation analysis of admixtures in certain semiconductive materials

    NASA Technical Reports Server (NTRS)

    Artyukhin, P. I.; Gilbert, E. P.; Pronin, V. A.

    1978-01-01

    The use of extractions and chromatographic operations to separate macrobases, and to divide elements into groups convenient for gamma-spectrometric analysis is discussed. Methods are described for the activation detection of some impurities in silicon, arsenic, thallium, and trichloromethylsilane, on the basis of the extraction properties of bis(2-chlorethyl ether) and dimethylbenzylalkylammonium chloride. A schematic diagram of the extraction separation of elements-admixture is presented showing the aqueous and organic phases. The content percentage of the various elements are given in tables.

  19. Interethnic admixture and the evolution of Latin American populations.

    PubMed

    Salzano, Francisco Mauro; Sans, Mónica

    2014-03-01

    A general introduction to the origins and history of Latin American populations is followed by a systematic review of the data from molecular autosomal assessments of the ethnic/continental (European, African, Amerindian) ancestries for 24 Latin American countries or territories. The data surveyed are of varying quality but provide a general picture of the present constitution of these populations. A brief discussion about the applications of these results (admixture mapping) is also provided. Latin American populations can be viewed as natural experiments for the investigation of unique anthropological and epidemiological issues.

  20. Interethnic admixture and the evolution of Latin American populations

    PubMed Central

    Salzano, Francisco Mauro; Sans, Mónica

    2014-01-01

    A general introduction to the origins and history of Latin American populations is followed by a systematic review of the data from molecular autosomal assessments of the ethnic/continental (European, African, Amerindian) ancestries for 24 Latin American countries or territories. The data surveyed are of varying quality but provide a general picture of the present constitution of these populations. A brief discussion about the applications of these results (admixture mapping) is also provided. Latin American populations can be viewed as natural experiments for the investigation of unique anthropological and epidemiological issues. PMID:24764751

  1. Antidromic His capture during entrainment of orthodromic AVRT.

    PubMed

    Nair, Krishnakumar; Selvaraj, Raja; Farid, Talha; Nanthakumar, Kumaraswamy

    2010-09-01

    A narrow QRS tachycardia with eccentric atrial activation is presented with features favoring an orthodromic atrioventricular re-entrant tachycardia including an extranodal paraHisian response, and a short corrected post-pacing interval to tachycardia cycle length difference following right ventricular entrainment. However, during entrainment, the H-H interval was entrained by the pacing train several beats prior to the A-A interval which would suggest an atrioventricular nodal re-entry tachycardia. We discuss the diagnosis and its mechanism.

  2. Flicker Regularity Is Crucial for Entrainment of Alpha Oscillations.

    PubMed

    Notbohm, Annika; Herrmann, Christoph S

    2016-01-01

    Previous studies have shown that alpha oscillations (8-13 Hz) in human electroencephalogram (EEG) modulate perception via phase-dependent inhibition. If entrained to an external driving force, inhibition maxima and minima of the oscillation appear more distinct in time and make potential phase-dependent perception predictable. There is an ongoing debate about whether visual stimulation is suitable to entrain alpha oscillations. On the one hand, it has been argued that a series of light flashes results in transient event-related responses (ERPs) superimposed on the ongoing EEG. On the other hand, it has been demonstrated that alpha oscillations become entrained to a series of light flashes if they are presented at a certain temporal regularity. This raises the question under which circumstances a sequence of light flashes causes entrainment, i.e., whether an arrhythmic stream of light flashes would also result in entrainment. Here, we measured detection rates in response to visual targets at two opposing stimulation phases during rhythmic and arrhythmic light stimulation. We introduce a new measure called "behavioral modulation depth" to determine differences in perception. This measure is capable of correcting for inevitable artifacts that occur in visual detection tasks during visual stimulation. The physical concept of entrainment predicts that increased stimulation intensity should produce stronger entrainment. Thus, two experiments with medium (Experiment 1) and high (Experiment 2) stimulation intensity were performed. Data from the first experiment show that the behavioral modulation depth (alpha phase-dependent differences in detection threshold) increases with increasing entrainment of alpha oscillations. Furthermore, individual alpha phase delays of entrained alpha oscillations determine the behavioral modulation depth: the largest behavioral modulation depth can be found if targets presented during the minimum of the entrained oscillation are compared to

  3. Rhythm as an affordance for the entrainment of movement.

    PubMed

    Cummins, Fred

    2009-01-01

    A general account of rhythm in human behaviour is provided, according to which rhythm inheres in the affordance that a signal provides for the entrainment of movement on the part of a perceiver. This generic account is supported by an explication of the central concepts of affordance and entrainment. When viewed in this light, rhythm appears as the correct explanandum to account for coordinated behaviour in a wide variety of situations, including such core senses as dance and the production of music. Speech may appear to be only marginally rhythmical under such an account, but several experimental studies reveal that speech, too, has the potential to entrain movement.

  4. Effect of various intake designs on zooplankton entrainment

    SciTech Connect

    Dycus, D.L.

    1983-03-01

    Field studies were conducted at the intakes of three Tennessee Valley Authority electric power plants to determine whether intake design is a feasible means of mitigating effects on zooplankton by minimizing the quantity entrained. Three intake designs were evaluated: one with a shallow skimmer wall, one with a deep skimmer wall, and one with no skimmer wall. Several studies indicated possible differences between day and night in the quantity of zooplankton entrained. None of these studies indicated that the intake designs studied minimized the quantity of zooplankton entrained because the quantities in the intake canals were similar to the quantities in the source water body.

  5. Flicker Regularity Is Crucial for Entrainment of Alpha Oscillations

    PubMed Central

    Notbohm, Annika; Herrmann, Christoph S.

    2016-01-01

    Previous studies have shown that alpha oscillations (8–13 Hz) in human electroencephalogram (EEG) modulate perception via phase-dependent inhibition. If entrained to an external driving force, inhibition maxima and minima of the oscillation appear more distinct in time and make potential phase-dependent perception predictable. There is an ongoing debate about whether visual stimulation is suitable to entrain alpha oscillations. On the one hand, it has been argued that a series of light flashes results in transient event-related responses (ERPs) superimposed on the ongoing EEG. On the other hand, it has been demonstrated that alpha oscillations become entrained to a series of light flashes if they are presented at a certain temporal regularity. This raises the question under which circumstances a sequence of light flashes causes entrainment, i.e., whether an arrhythmic stream of light flashes would also result in entrainment. Here, we measured detection rates in response to visual targets at two opposing stimulation phases during rhythmic and arrhythmic light stimulation. We introduce a new measure called “behavioral modulation depth” to determine differences in perception. This measure is capable of correcting for inevitable artifacts that occur in visual detection tasks during visual stimulation. The physical concept of entrainment predicts that increased stimulation intensity should produce stronger entrainment. Thus, two experiments with medium (Experiment 1) and high (Experiment 2) stimulation intensity were performed. Data from the first experiment show that the behavioral modulation depth (alpha phase-dependent differences in detection threshold) increases with increasing entrainment of alpha oscillations. Furthermore, individual alpha phase delays of entrained alpha oscillations determine the behavioral modulation depth: the largest behavioral modulation depth can be found if targets presented during the minimum of the entrained oscillation are

  6. Auditory-motor entrainment in vocal mimicking species: Additional ontogenetic and phylogenetic factors.

    PubMed

    Schachner, Adena

    2010-05-01

    We have recently found robust evidence of motor entrainment to auditory stimuli in multiple species of non-human animal, all of which were capable of vocal mimicry. In contrast, the ability remained markedly absent in many closely related species incapable of vocal mimicry. This suggests that vocal mimicry may be a necessary precondition for entrainment. However, within the vocal mimicking species, entrainment appeared non-randomly, suggesting that other components besides vocal mimicry play a role in the capacity and tendency to entrain. Here we discuss potential additional factors involved in entrainment. New survey data show that both male and female parrots are able to entrain, and that the entrainment capacity appears throughout the lifespan. We suggest routes for future study of entrainment, including both developmental studies in species known to entrain and further work to detect entrainment in species not well represented in our dataset. These studies may shed light on additional factors necessary for entrainment in addition to vocal mimicry.

  7. PDF as a coupling mediator between the light-entrainable and temperature-entrainable clocks in Drosophila melanogaster.

    PubMed

    Tomioka, K; Miyasako, Y; Umezaki, Y

    2008-01-01

    Drosophila shows bimodal circadian locomotor rhythms with peaks around light-on (morning peak) and before light-off (evening peak). The rhythm synchronizes to light and temperature cycles and the synchronization is achieved by two sets of clocks: one entrains to light cycles and the other to temperature cycles. The light-entrainable clock consists of the clock neurons located in the lateral protocerebrum (LNs) and the temperature-entrainable clock involves those located in the dorsal protocerebrum (DNs) and the cells located in the posterior lateral protocerebrum (LPNs). To understand the interaction between the light-entrainable and the temperature-entrainable clock neurons, locomotor rhythms of the mutant flies lacking PDF or PDF-positive clock neurons were examined. Under the light cycles, they showed altered phase of the evening peak. When exposed to temperature cycles of lower temperature levels, the onset of evening peak showed larger advance in contrast to those of wild-type flies. The termination of the peak also advanced while that of wild-type flies remained almost at the same phase as in the constant temperature. These results support our hypothesis that the PDF-positive light entrainable cells regulate the phase of the temperature entrainable cells to be synchronized to their own phase using PDF as a coupling mediator.

  8. Mutual entrainment of bilaterally distributed circadian pacemaker.

    PubMed Central

    Page, T L; Caldarola, P C; Pittendrigh, C S

    1977-01-01

    The interactions between the bilaterally distributed components of the circadin system that controls the locomotor activity rhythm of the cockroach Leucophaea maderae were investigated in a series of surgical lesion experiments. Complete excision of one optic lobe (either right or left) or its surgical isolation from the central nervous system had no effect on the animals' ability to free-run in constant darkness nor was there any indication, as judged by postoperative pi values of any difference between left and right lobe pacemakers. However, these surgical procedures consistently resulted in a significant increase in tau over preoperative value while optic nerve section had no effect on tau. The propostion is developed that the left and right pacemakers in the two optic lobes are mutally coupled and that the compound pacemaker's period is shorter than either of its constituent pacemakers. It was also found that the integrity of either compound eye is sufficient to assure entrainment of both left and right pacemakers. Images PMID:265571

  9. Organic Entrainment and Preservation in Volcanic Glasses

    NASA Technical Reports Server (NTRS)

    Wilhelm, Mary Beth; Ojha, Lujendra; Brunner, Anna E.; Dufek, Josef D.; Wray, James Joseph

    2014-01-01

    Unaltered pyroclastic deposits have previously been deemed to have "low" potential for the formation, concentration and preservation of organic material on the Martian surface. Yet volcanic glasses that have solidified very quickly after an eruption may be good candidates for containment and preservation of refractory organic material that existed in a biologic system pre-eruption due to their impermeability and ability to attenuate UV radiation. Analysis using NanoSIMS of volcanic glass could then be performed to both deduce carbon isotope ratios that indicate biologic origin and confirm entrainment during eruption. Terrestrial contamination is one of the biggest barriers to definitive Martian organic identification in soil and rock samples. While there is a greater potential to concentrate organics in sedimentary strata, volcanic glasses may better encapsulate and preserve organics over long time scales, and are widespread on Mars. If volcanic glass from many sites on Earth could be shown to contain biologically derived organics from the original environment, there could be significant implications for the search for biomarkers in ancient Martian environments.

  10. Music and emotions: from enchantment to entrainment.

    PubMed

    Vuilleumier, Patrik; Trost, Wiebke

    2015-03-01

    Producing and perceiving music engage a wide range of sensorimotor, cognitive, and emotional processes. Emotions are a central feature of the enjoyment of music, with a large variety of affective states consistently reported by people while listening to music. However, besides joy or sadness, music often elicits feelings of wonder, nostalgia, or tenderness, which do not correspond to emotion categories typically studied in neuroscience and whose neural substrates remain largely unknown. Here we review the similarities and differences in the neural substrates underlying these "complex" music-evoked emotions relative to other more "basic" emotional experiences. We suggest that these emotions emerge through a combination of activation in emotional and motivational brain systems (e.g., including reward pathways) that confer its valence to music, with activation in several other areas outside emotional systems, including motor, attention, or memory-related regions. We then discuss the neural substrates underlying the entrainment of cognitive and motor processes by music and their relation to affective experience. These effects have important implications for the potential therapeutic use of music in neurological or psychiatric diseases, particularly those associated with motor, attention, or affective disturbances.

  11. Granular motions near the threshold of entrainment

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Alexakis, athanasios-Theodosios

    2016-04-01

    Our society is continuously impacted by significant weather events many times resulting in catastrophes that interrupt our normal way of life. In the context of climate change and increasing urbanisation these "extreme" hydrologic events are intensified both in magnitude and frequency, inducing costs of the order of billions of pounds. The vast majority of such costs and impacts (even more to developed societies) are due to water related catastrophes such as the geomorphic action of flowing water (including scouring of critical infrastructure, bed and bank destabilisation) and flooding. New tools and radically novel concepts are in need, to enable our society becoming more resilient. This presentation, emphasises the utility of inertial sensors in gaining new insights on the interaction of flow hydrodynamics with the granular surface at the particle scale and for near threshold flow conditions. In particular, new designs of the "smart-sphere" device are discussed with focus on the purpose specific sets of flume experiments, designed to identify the exact response of the particle resting at the bed surface for various below, near and above threshold flow conditions. New sets of measurements are presented for particle entrainment from a Lagrangian viewpoint. Further to finding direct application in addressing real world challenges in the water sector, it is shown that such novel sensor systems can also help the research community (both experimentalists and computational modellers) gain a better insight on the underlying processes governing granular dynamics.

  12. Relationship between gallbladder surgery and ethnic admixture in African American and Hispanic American women.

    PubMed

    Nassir, Rami; Qi, Lihong; Kosoy, Roman; Garcia, Lorena; Robbins, John; Seldin, Michael F

    2012-06-01

    The objective of this study was to investigate whether differences in admixture in African American and Hispanic American adult women are associated with differences in gallbladder surgery. Gallbladder surgery history on entry to the Women's Health Initiative's (WHI) study was used as a dichotomous outcome measure for this study. The proportion of European, sub-Saharan African, and Amerindian (AMI) admixture was estimated for 10,841 African American and 4,620 Hispanic American women in WHI using 92 ancestry informative markers. Logistic regression analyses assessed the relationship between admixture and gallbladder surgery in WHI women (enrollment at ages >50, mean age 61 years) with or without adjusting for multiple covariates, including measures of adiposity, parity, alcohol use, and education. There was a significant positive association between AMI admixture and the frequency of gallbladder surgery in Hispanic Americans. The odds ratio (OR) and 95% confidence intervals (CIs) for AMI admixture group was OR=2.97, CI=2.01-4.38, P<10(-4). Although there were strong positive associations with parity and adiposity, and negative associations with alcohol consumption and education, accounting for these covariates did not remove the admixture association (OR=2.46, CI=1.62-3.73). In contrast, the effect of African admixture was nearly indistinguishable from that of the European admixture, both of which were protective in the Hispanic American group, and African admixture had a marginal association with decreased gallbladder surgery in the African American group. Measures of adiposity were associated with increased risk for gallbladder surgery and remained significant after accounting for admixture and each of the other covariates. Education level and alcohol use were associated with decreased risk for gallbladder disease. However, after accounting for the other covariates these variably remained significant. AMI admixture is strongly associated with gallbladder surgery

  13. A comparative efficacy study of photic driving brainwave entrainment technology with a novel form of more direct entrainment

    NASA Astrophysics Data System (ADS)

    Knowles, Richard Thomas

    This exploratory study compared the efficacy of a novel brainwave electromagnetic (EM) entrainment technology against a more conventional technology utilizing the photic-driving technique. Both experimental conditions were also compared with a 7-minute control session that took place immediately before each stimulation session. The Schumann Resonance (SR) frequency was selected as the delivery signal and was chosen because of previous findings suggesting that entrainment to this frequency can often produce transpersonal if not paranormal, experiences in the entrainee, which sometimes resemble remote viewing or out-of-body experiences. A pilot study determined which of two novel entrainment modalities (a copper coil or a 16-solenoid headset) worked most effectively for use with the rest of the study. In the main study, an artificial SR signal at 7.8Hz was delivered during the photic-driving sessions, but a recording of the real-time SR was used to deliver the entrainment signal during sessions devoted to the electromagnetic entrainment modality. Sixteen participants were recruited from the local area, and EEG recordings were acquired via a 32-channel Deymed electroencephalography system. Comparative analyses were performed between the control and experimental portions of each session to assess for efficacy of the novel entrainment modality used, and, in the main study, between the electromagnetic and photic-driving sessions, to assess for differential entrainment efficacy between these groups. A follow-up study was additionally performed primarily to determine whether responders could replicate their entrainment effect from the main study. Results showed that EM entrainment appeared to be possible but is not nearly as robust or reliable as photic driving. Additionally, no profound transpersonal or paranormal experiences were elicited during the course of the study, and, when asked, participants were not able to determine with any degree of success, when the

  14. Performance Using Bamboo Fiber Ash Concrete as Admixture Adding Superplasticizer

    NASA Astrophysics Data System (ADS)

    Vasudevan, Gunalaan

    2017-06-01

    The increasing demand on natural resources for housing provisions in developing countries have called for sourcing and use of sustainable local materials for building and housing delivery. Natural materials to be considered sustainable for building construction should be ‘green’ and obtained from local sources, including rapidly renewable plant materials like palm fronds and bamboo, recycled materials and other products that are reusable and renewable. Each year, tens of millions of tons of bamboo are utilized commercially, generating a vast amount of waste. Besides that, bamboo fiber is easy availability, low density, low production cost and satisfactory mechanical properties. One solution is to activate this waste by using it as an additive admixture in concrete to keep it out of landfills and save money on waste disposal. The research investigates the mechanical and physical properties of bamboo fiber powder in a blended Portland cement. The structural value of the bamboo fiber powder in a blended Portland cement was evaluated with consideration for its suitability in concrete. Varied percentage of bamboo fiber powder (BFP) at 0%, 5%, 10%, 15%, and 20% as an admixture in 1:2:4 concrete mixes. The workability of the mix was determined through slump; standard consistency test was carried on the cement. Compressive strength of hardened cured (150 x 150 x 150) mm concrete cubes at 7days, 14days and 28days were tested.

  15. Ancestry informative markers and admixture proportions in northeastern Mexico.

    PubMed

    Martinez-Fierro, Margarita L; Beuten, Joke; Leach, Robin J; Parra, Esteban J; Cruz-Lopez, Miguel; Rangel-Villalobos, Hector; Riego-Ruiz, Lina R; Ortiz-Lopez, Rocio; Martinez-Rodriguez, Herminia G; Rojas-Martinez, Augusto

    2009-09-01

    To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4-81.2%), the European contribution is 38% (range: 16.7-70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers ( approximately 78%), compared with Amerindian ( approximately 12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for population-based association studies of complex diseases.

  16. Dyslipidemia in racially admixtured children with cystic fibrosis

    PubMed Central

    Alves, Cresio; Lima, Daniela; Cardeal, Mauricio; Santana, Angelica

    2012-01-01

    Objectives: There are few studies reporting lipid profile in cystic fibrosis (CF) and most of them are in adult Caucasians. Therefore, the aim of this study was to evaluate the lipid profile of racially admixtured youths with CF. Materials and Methods: A cross-sectional survey conducted between August and September 2009 at a reference service for CF, evaluating clinical and laboratory data. Results: Forty-six patients aged from 6 years to 16 years and 2 months (median: 9 years and 10 months; 65.2% males) were evaluated. Of these, 26% were Whites, 54.4% Mulattoes and 19.6% Blacks. There were no diabetics, one patient had glucose intolerance and three had insulin resistance. Pancreatic sufficiency was present in 74% and malnutrition in 26% of the patients. The lipid profile revealed hypertriglyceridemia in 56%, hypercholesterolemia in 17.4% and hypocholesterolemia in 46.5%. In 30.4% of the patients, hypertriglyceridemia and hypocholesterolemia was observed. The serum levels of high density lipoprotein (HDL) were low in 56.5% and the low density lipoprotein (LDL) elevated in 15.2% of the patients. Conclusions: The lipid profile of this sample of Brazilian racially admixtured patients with CF showed a higher prevalence of hypertriglyceridemia and hypocholesterolemia. There was no association of dyslipidemia with the various racial groups, nutritional status, pancreatic sufficiency or glucose tolerance. PMID:22837921

  17. Depth of penetration of bubbles entrained by a plunging water jet

    NASA Astrophysics Data System (ADS)

    Clanet, Christophe; Lasheras, Juan C.

    1997-07-01

    A model is proposed to predict the depth of penetration of the air bubbles entrained by a round water jet impacting into a flat, liquid pool. This depth is shown to be determined only by the initial jet momentum and by the non-monotonic nature of the bubble terminal velocities as a function of their size. The model is shown to be in excellent agreement with measurements of the depth and width of penetration of the bubbles performed over a wide range of jet diameters, velocities, and plunging angles.

  18. Entrainment of a Synthetic Oscillator through Queueing Coupling

    NASA Astrophysics Data System (ADS)

    Hochendoner, Philip; Mather, William; Butzin, Nicholas; Ogle, Curtis

    2014-03-01

    Many biological systems naturally exhibit (often noisy) oscillatory patterns that are capable of being entrained by external stimuli, though the mechanism of entrainment is typically obscured by the complexity of native networks. A synthetic biology approach, where genetic programs are wired ``by hand,'' has proven useful in this regard. In the present study, we use a synthetic oscillator in Escherichia coli to demonstrate a novel and potentially widespread mechanism for biological entrainment: competition of proteins for degradation by common pathway, i.e. a entrainment by a bottleneck. To faithfully represent the discrete and stochastic nature of this bottleneck, we leverage results from a recent biological queueing theory, where in particular, the queueing theoretic concept of workload is discovered to simplify the analysis. NSF Award 1330180.

  19. How coupling determines the entrainment of circadian clocks

    NASA Astrophysics Data System (ADS)

    Bordyugov, G.; Granada, A. E.; Herzel, H.

    2011-08-01

    Autonomous circadian clocks drive daily rhythms in physiology and behaviour. A network of coupled neurons, the suprachiasmatic nucleus (SCN), serves as a robust self-sustained circadian pacemaker. Synchronization of this timer to the environmental light-dark cycle is crucial for an organism's fitness. In a recent theoretical and experimental study it was shown that coupling governs the entrainment range of circadian clocks. We apply the theory of coupled oscillators to analyse how diffusive and mean-field coupling affects the entrainment range of interacting cells. Mean-field coupling leads to amplitude expansion of weak oscillators and, as a result, reduces the entrainment range. We also show that coupling determines the rigidity of the synchronized SCN network, i.e. the relaxation rates upon perturbation. Our simulations and analytical calculations using generic oscillator models help to elucidate how coupling determines the entrainment of the SCN. Our theoretical framework helps to interpret experimental data.

  20. Differential Entrainment of Neuroelectric Delta Oscillations in Developmental Dyslexia

    PubMed Central

    Soltész, Fruzsina; Szűcs, Denes; Leong, Victoria; White, Sonia; Goswami, Usha

    2013-01-01

    Oscillatory entrainment to the speech signal is important for language processing, but has not yet been studied in developmental disorders of language. Developmental dyslexia, a difficulty in acquiring efficient reading skills linked to difficulties with phonology (the sound structure of language), has been associated with behavioural entrainment deficits. It has been proposed that the phonological ‘deficit’ that characterises dyslexia across languages is related to impaired auditory entrainment to speech at lower frequencies via neuroelectric oscillations (<10 Hz, ‘temporal sampling theory’). Impaired entrainment to temporal modulations at lower frequencies would affect the recovery of the prosodic and syllabic structure of speech. Here we investigated event-related oscillatory EEG activity and contingent negative variation (CNV) to auditory rhythmic tone streams delivered at frequencies within the delta band (2 Hz, 1.5 Hz), relevant to sampling stressed syllables in speech. Given prior behavioural entrainment findings at these rates, we predicted functionally atypical entrainment of delta oscillations in dyslexia. Participants performed a rhythmic expectancy task, detecting occasional white noise targets interspersed with tones occurring regularly at rates of 2 Hz or 1.5 Hz. Both groups showed significant entrainment of delta oscillations to the rhythmic stimulus stream, however the strength of inter-trial delta phase coherence (ITC, ‘phase locking’) and the CNV were both significantly weaker in dyslexics, suggestive of weaker entrainment and less preparatory brain activity. Both ITC strength and CNV amplitude were significantly related to individual differences in language processing and reading. Additionally, the instantaneous phase of prestimulus delta oscillation predicted behavioural responding (response time) for control participants only. PMID:24204644

  1. Vibrational Energy Coupling in Expanding N2/O2/NO Admixtures

    NASA Technical Reports Server (NTRS)

    Gilmore, John O.; Sharma, Surendra P.; Cavolowsky, John A. (Technical Monitor)

    1995-01-01

    Recent direct measurements of N2 and O2 vibrational populations in expansions of synthetic air show a closer coupling of the vibrational energies than indicated by adapting earlier experimental results from shock compressions to the nozzle expansion problem. An important difference between the shock wave and nozzle flow problems is the presence of NO in significant amounts throughout the relaxation in the case of a nozzle flow. This may account for the stronger coupling since NO is well suited to promote vibrational energy exchange. The results of a series of experiments and analysis examining vibrational energy coupling in expansions of admixtures approximating air are reported. N2 and O2 vibrational populations are determined by a single-pulse spontaneous Raman scattering technique. NO vibrational populations are determined by broadband absorption by the NO(y) system. The resulting data permit the role of NO in promoting vibrational energy coupling to be better understood, and are used to evaluate models of vibrational energy exchange for application to expanding flows.

  2. Patterns of Admixture and Population Structure in Native Populations of Northwest North America

    PubMed Central

    Verdu, Paul; Pemberton, Trevor J.; Laurent, Romain; Kemp, Brian M.; Gonzalez-Oliver, Angelica; Gorodezky, Clara; Hughes, Cris E.; Shattuck, Milena R.; Petzelt, Barbara; Mitchell, Joycelynn; Harry, Harold; William, Theresa; Worl, Rosita; Cybulski, Jerome S.; Rosenberg, Noah A.; Malhi, Ripan S.

    2014-01-01

    The initial contact of European populations with indigenous populations of the Americas produced diverse admixture processes across North, Central, and South America. Recent studies have examined the genetic structure of indigenous populations of Latin America and the Caribbean and their admixed descendants, reporting on the genomic impact of the history of admixture with colonizing populations of European and African ancestry. However, relatively little genomic research has been conducted on admixture in indigenous North American populations. In this study, we analyze genomic data at 475,109 single-nucleotide polymorphisms sampled in indigenous peoples of the Pacific Northwest in British Columbia and Southeast Alaska, populations with a well-documented history of contact with European and Asian traders, fishermen, and contract laborers. We find that the indigenous populations of the Pacific Northwest have higher gene diversity than Latin American indigenous populations. Among the Pacific Northwest populations, interior groups provide more evidence for East Asian admixture, whereas coastal groups have higher levels of European admixture. In contrast with many Latin American indigenous populations, the variance of admixture is high in each of the Pacific Northwest indigenous populations, as expected for recent and ongoing admixture processes. The results reveal some similarities but notable differences between admixture patterns in the Pacific Northwest and those in Latin America, contributing to a more detailed understanding of the genomic consequences of European colonization events throughout the Americas. PMID:25122539

  3. Effects of Different Mineral Admixtures on the Properties of Fresh Concrete

    PubMed Central

    Nuruddin, Muhammad Fadhil; Shafiq, Nasir

    2014-01-01

    This paper presents a review of the properties of fresh concrete including workability, heat of hydration, setting time, bleeding, and reactivity by using mineral admixtures fly ash (FA), silica fume (SF), ground granulated blast furnace slag (GGBS), metakaolin (MK), and rice husk ash (RHA). Comparison of normal and high-strength concrete in which cement has been partially supplemented by mineral admixture has been considered. It has been concluded that mineral admixtures may be categorized into two groups: chemically active mineral admixtures and microfiller mineral admixtures. Chemically active mineral admixtures decrease workability and setting time of concrete but increase the heat of hydration and reactivity. On the other hand, microfiller mineral admixtures increase workability and setting time of concrete but decrease the heat of hydration and reactivity. In general, small particle size and higher specific surface area of mineral admixture are favourable to produce highly dense and impermeable concrete; however, they cause low workability and demand more water which may be offset by adding effective superplasticizer. PMID:24701196

  4. [Effect of admixture of betamethasone butyrate propionate ointment on preservative efficacy].

    PubMed

    Ohtani, Michiteru; Nakai, Tatsurou; Ohsawa, Kouji; Kim, Soan; Matsumoto, Mika; Etoh, Takafumi; Kariya, Satoru; Kanou, Syoujirou; Uchino, Katsuyoshi

    2002-12-01

    Twenty percent of dermatologists have experienced a separation of water or deterioration of topical corticosteroids mixed with commercially available ointments and/or creams. However, few investigations of this deterioration of admixtures have been reported. To assess the effects of preservatives in preventing microbial contamination of these admixtures, we attempted to investigate the concentration of preservative agents in admixtures and the microbial contamination of these admixtures with a topical corticosteroid ointment (Antebate). The concentration of parabens was reduced by half using an admixture of corticosteroid ointment with four types of moisturizing creams, Urepearl, Pastaronsoft, Hirudoid, and Hirudoidsoft. After a further 3 months, no decrease in parabens was seen. No microbial contamination was found in any admixture stored at room temperature for 1 week and touched two times daily with a finger. The concentration and ratio of the parabens in the aqueous phase and oil phase were entirely different in the admixtures before being centrifuged. The aqueous phase of the admixtures of the oil/water (O/W)-type emulsions of Urepearl and Hirudoid was not found to have microbial contamination immediately after being centrifuged. All aqueous phases stored at room temperature or in a refrigerator for 1 week and touched with a finger twice daily exhibited microbial contamination. These experiments demonstrated that O/W-type emulsions, in which the water easily separates from the bases, should be thoroughly mixed to prevent microbial contamination.

  5. Bayesian analysis of an admixture model with mutations and arbitrarily linked markers.

    PubMed

    Excoffier, Laurent; Estoup, Arnaud; Cornuet, Jean-Marie

    2005-03-01

    We introduce here a Bayesian analysis of a classical admixture model in which all parameters are simultaneously estimated. Our approach follows the approximate Bayesian computation (ABC) framework, relying on massive simulations and a rejection-regression algorithm. Although computationally intensive, this approach can easily deal with complex mutation models and partially linked loci, and it can be thoroughly validated without much additional computation cost. Compared to a recent maximum-likelihood (ML) method, the ABC approach leads to similarly accurate estimates of admixture proportions in the case of recent admixture events, but it is found superior when the admixture is more ancient. All other parameters of the admixture model such as the divergence time between parental populations, the admixture time, and the population sizes are also well estimated, unlike the ML method. The use of partially linked markers does not introduce any particular bias in the estimation of admixture, but ML confidence intervals are found too narrow if linkage is not specifically accounted for. The application of our method to an artificially admixed domestic bee population from northwest Italy suggests that the admixture occurred in the last 10-40 generations and that the parental Apis mellifera and A. ligustica populations were completely separated since the last glacial maximum.

  6. How important is intraspecific genetic admixture to the success of colonising populations?

    EPA Science Inventory

    Genetic admixture of divergent lineages is increasingly suspected to play an important role in the success of colonizing populations. This has become a particularly prominent theme in the literature on biological invasions, where admixture is now commonly proposed as an important...

  7. Patterns of admixture and population structure in native populations of Northwest North America.

    PubMed

    Verdu, Paul; Pemberton, Trevor J; Laurent, Romain; Kemp, Brian M; Gonzalez-Oliver, Angelica; Gorodezky, Clara; Hughes, Cris E; Shattuck, Milena R; Petzelt, Barbara; Mitchell, Joycelynn; Harry, Harold; William, Theresa; Worl, Rosita; Cybulski, Jerome S; Rosenberg, Noah A; Malhi, Ripan S

    2014-08-01

    The initial contact of European populations with indigenous populations of the Americas produced diverse admixture processes across North, Central, and South America. Recent studies have examined the genetic structure of indigenous populations of Latin America and the Caribbean and their admixed descendants, reporting on the genomic impact of the history of admixture with colonizing populations of European and African ancestry. However, relatively little genomic research has been conducted on admixture in indigenous North American populations. In this study, we analyze genomic data at 475,109 single-nucleotide polymorphisms sampled in indigenous peoples of the Pacific Northwest in British Columbia and Southeast Alaska, populations with a well-documented history of contact with European and Asian traders, fishermen, and contract laborers. We find that the indigenous populations of the Pacific Northwest have higher gene diversity than Latin American indigenous populations. Among the Pacific Northwest populations, interior groups provide more evidence for East Asian admixture, whereas coastal groups have higher levels of European admixture. In contrast with many Latin American indigenous populations, the variance of admixture is high in each of the Pacific Northwest indigenous populations, as expected for recent and ongoing admixture processes. The results reveal some similarities but notable differences between admixture patterns in the Pacific Northwest and those in Latin America, contributing to a more detailed understanding of the genomic consequences of European colonization events throughout the Americas.

  8. Gender and population history: sex bias revealed by studying genetic admixture of Ngazidja population (Comoro Archipelago).

    PubMed

    Gourjon, Géraud; Boëtsch, Gilles; Degioanni, Anna

    2011-04-01

    The peopling of Comoro Archipelago is defined by successive waves of migration from three main areas: the East African Coast (Bantu-speaking populations), the Persia and Arabian Peninsula, and Southeast Asia (especially Indonesia). It follows an apparent classic trihybrid admixture model. To better understand the Comorian population admixture dynamics, we analyzed the contributions of these three historical parental components to its genetic pool. To enhance accuracy and reliability, we used both classical and molecular markers. Samples consist of published data: blood group frequencies, 14 KIR genes, 19 mitochondrial DNA SNPs (to highlight female migrations), 14 Y chromosome SNPs (male migrations). We revealed distinct admixture patterns for autosomal and uniparental markers. KIR gene frequencies had never been used to estimate admixture rates, this being a first assessment of their informative power in admixture studies. To avoid major methodological and statistical bias, we determined admixture coefficients through nine well-tried estimators and their associated software programs (ADMIX95, ADMIX, admix 2.0, LEA, LEADMIX, and Mistura). Results from mtDNA and Y chromosome markers point to an important sex-bias in the admixture event. The original Bantu gene pool received a predominant male-mediated contribution from the Arabian Peninsula and Persia, and a female-mediated contribution from Southeast Asia. Admixture rates estimated from autosomal KIR gene markers point also to an unexpected elevated Austronesian contribution.

  9. How important is intraspecific genetic admixture to the success of colonising populations?

    EPA Science Inventory

    Genetic admixture of divergent lineages is increasingly suspected to play an important role in the success of colonizing populations. This has become a particularly prominent theme in the literature on biological invasions, where admixture is now commonly proposed as an important...

  10. Impaired auditory-to-motor entrainment in Parkinson's disease.

    PubMed

    Te Woerd, Erik S; Oostenveld, Robert; De Lange, Floris Pieter; Praamstra, Peter

    2017-02-08

    Several electrophysiological studies suggest that PD patients have a reduced tendency to entrain to regular environmental patterns. Here we investigate whether this reduced entrainment concerns a generalized deficit or is confined to movement-related activity, leaving sensory entrainment intact. Magnetoencephalography (MEG) was recorded during a rhythmic auditory target detection task in 14 PD patients and 14 control subjects. Participants were instructed to press a button when hearing a target tone amidst an isochronous sequence of standard tones. The variable pitch of standard tones indicated the probability of the next tone to be a target. In addition, targets were occasionally omitted to evaluate entrainment uncontaminated by stimulus effects. Response times were not significantly different between groups and both groups benefited equally from the predictive value of standard tones. Analyses of oscillatory beta power over auditory cortices showed equal entrainment to the tones in both groups. By contrast, oscillatory beta power and event-related fields (ERFs) demonstrated a reduced engagement of motor cortical areas in PD patients, expressed in the modulation depth of beta power, in the response to omitted stimuli, and in an absent motor area P300 effect. Together, these results show equally strong entrainment of neural activity over sensory areas in controls and patients, but, in patients, a deficient translation of the adjustment to the task rhythm to motor circuits. We suggest that the reduced activation does not merely reflect altered resonance to rhythmic external events, but a compromised recruitment of an endogenous response reflecting internal rhythm generation.

  11. Entrainment of the master circadian clock by scheduled feeding.

    PubMed

    Castillo, Marina R; Hochstetler, Kelly J; Tavernier, Ronald J; Greene, Dana M; Bult-Ito, Abel

    2004-09-01

    The master circadian clock, located in the mammalian suprachiasmatic nuclei (SCN), generates and coordinates circadian rhythmicity, i.e., internal organization of physiological and behavioral rhythms that cycle with a near 24-h period. Light is the most powerful synchronizer of the SCN. Although other nonphotic cues also have the potential to influence the circadian clock, their effects can be masked by photic cues. The purpose of this study was to investigate the ability of scheduled feeding to entrain the SCN in the absence of photic cues in four lines of house mouse (Mus domesticus). Mice were initially housed in 12:12-h light/dark cycle with ad libitum access to food for 6 h during the light period followed by 4-6 mo of constant dark under the same feeding schedule. Wheel running behavior suggested and circadian PER2 protein expression profiles in the SCN confirmed entrainment of the master circadian clock to the onset of food availability in 100% (49/49) of the line 2 mice in contrast to only 4% (1/24) in line 3 mice. Mice from line 1 and line 4 showed intermediate levels of entrainment, 57% (8/14) and 39% (7/18), respectively. The predictability of entrainment vs. nonentrainment in line 2 and line 3 and the novel entrainment process provide a powerful tool with which to further elucidate mechanisms involved in entrainment of the SCN by scheduled feeding.

  12. Rhythmic entrainment as a musical affect induction mechanism.

    PubMed

    J Trost, W; Labbé, C; Grandjean, D

    2017-02-01

    One especially important feature of metrical music is that it contains periodicities that listeners' bodily rhythms can adapt to. Recent psychological frameworks have introduced the notion of rhythmic entrainment, among other mechanisms, as an emotion induction principle. In this review paper, we discuss rhythmic entrainment as an affect induction mechanism by differentiating four levels of entrainment in humans-perceptual, autonomic physiological, motor, and social-all of which could contribute to a subjective feeling component. We review the theoretical and empirical literature on rhythmic entrainment to music that supports the existence of these different levels of entrainment by describing the phenomena and characterizing the associated underlying brain processes. The goal of this review is to present the theoretical implications and empirical findings about rhythmic entrainment as an important principle at the basis of affect induction via music, since it rests upon the temporal dimension of music, which is a specificity of music as an affective stimulus. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Entrainment and detrainment in a simple cumulus cloud model

    NASA Technical Reports Server (NTRS)

    Randall, D. A.; Huffman, G. J.

    1982-01-01

    A cumulus cloud model, analogous to the mixed-layer models of the planetary boundary layer and the upper ocean, is developed using a single, unitary entrainment process in which the motion of the cloud boundary relative to the mean flow is permitted, produced, and controlled by turbulent processes. An alternate theory to the mixing-length theory of Asai and Kasahara (1967) is proposed which completely removes the strong scale-dependence of the Asai-Kasahara model. The model reintroduces scale-dependence by introducing including the pe5turbation pressure term of the equation of vertical motion. It is shown that the model predicts deeper clouds than the Asai-Kasahara model for a given sounding, due to the entrainment assumption and the effects of the perturbation pressure. Lateral entrainment dominates cloud-top entrainment, although finite-difference errors increase the cloud-top entrainment rate from zero to a positive value in actual situations. The fractional entrainment rate for updrafts is determined to vary only slightly with height and to decrease only slowly as the cloud radius increases, while the fractional detrainment rate for updrafts increases with height.

  14. Synthesis of Entrainment and Detrainment formulations for Convection Parameterizations

    NASA Astrophysics Data System (ADS)

    Siebesma, P.

    2015-12-01

    Mixing between convective clouds and its environment, usually parameterized in terms of entrainment and detrainment, are among the most important processes that determine the strength of the climate model sensitivity. This notion has led to a renaissance of research in exploring the mechanisms of these mixing processes and, as a result, to a wide range of seemingly different parameterized formulations. In this study we are aiming to synthesize these results as to offer a solid framework for use in parameterized formulations of convection. Detailed LES analyses in which clouds are subsampled according to their size show that entrainment rates are inversely proportional to the typical cloud radius, in accordance with original entraining plume models. These results can be shown analytically to be consistent with entrainment rate formulations of cloud ensembles that decrease inversely proportional with height, by making only mild assumptions on the shape of the associated cloud size distribution. In addition there are additional dependencies of the entrainment rates on the environmental thermodynamics such as the relative humidity and stability but these are of second order. In contrast detrainment rates do depend to first order on the environmental thermodynamics such as relative humidity and stability. This can be understood by realizing that i) the details of the cloud size distribution do depend on these environmental factors and ii) that detrainment rates have a much stronger dependency on the shape of the cloud size distribution than entrainment rates.

  15. Turbulent Entrainment into Non-Newtonian Fluid Mud Gravity Currents

    NASA Astrophysics Data System (ADS)

    Jacobson, Michael; Testik, Firat

    2011-11-01

    This study presents insights into turbulent entrainment of ambient water into fluid mud gravity currents. It is well established that fluid mud suspensions exhibit pseudo-plastic behavior. Gravity current laboratory experiments were conducted for constant-volume release configuration with different initial concentrations of fluid mud, representing different rheological properties (i.e. different Power-law model constants). A high quality data set of concentration and velocity profiles of fluid mud gravity currents was collected to calculate the entrainment velocity, we. The entrainment ratio (E =we / U , U - characteristic velocity) was calculated following the well-accepted Morton-Taylor-Turner entrainment hypothesis, which states that the inflow across the edge of a turbulent flow is proportional to some characteristic velocity. The entrainment ratio was further measured qualitatively using a light opaqueness technique. A semi-empirical parameterization for the entrainment ratio is proposed. The findings of this study are expected to be of significance for modeling various non-Newtonian gravity currents, in particular for modeling fluid mud gravity currents generated during dredge disposal operations in coastal waters. Contact Author.

  16. Laboratory experiments on stability and entrainment of oceanic stratocumulus. Part 2: Entrainment experiment

    NASA Technical Reports Server (NTRS)

    Shy, Shenqyang S.

    1990-01-01

    A stratified interface is stable to the buoyancy reversal instability for surprisingly large values of D (buoyancy reversal parameter). A new instability mechanism is proposed, which considers the mixing process at the interface. For the type of density curves studied here, under strong perturbations, the mixed parcel must have a buoyancy reversal comparable to the initial stratification before the interface is unstable. This is in accord with a simple model of the interface mixing process, as well as aircraft observations of long-live marine stratocumulus clouds. These clouds' remarkable longevity in the face of finite D indicates that they can be stable (Hanson, 1984; Albrecht et al., 1985; Siems et al., 1989). It is suggested that buoyancy reversal as well as the disturbance must be large for Cloudtop Entrainment Stability. The effect of buoyancy reversal (evaporative cooling) does not always enhance the entrainment rate over that in the inert case, but it may be negligible if Ri (Richardson number) is large (Ri is larger than 50) and D is small (D is smaller than 0.5). This work may shed some light on the fundamental mechanism of the breakup process of the subtropical stratocumulus clouds into tradewind cumulus. These results may also be related to the instability in the Weddell Sea off of Antarctica.

  17. Speech entrainment compensates for Broca's area damage.

    PubMed

    Fridriksson, Julius; Basilakos, Alexandra; Hickok, Gregory; Bonilha, Leonardo; Rorden, Chris

    2015-08-01

    Speech entrainment (SE), the online mimicking of an audiovisual speech model, has been shown to increase speech fluency in patients with Broca's aphasia. However, not all individuals with aphasia benefit from SE. The purpose of this study was to identify patterns of cortical damage that predict a positive response SE's fluency-inducing effects. Forty-four chronic patients with left hemisphere stroke (15 female) were included in this study. Participants completed two tasks: 1) spontaneous speech production, and 2) audiovisual SE. Number of different words per minute was calculated as a speech output measure for each task, with the difference between SE and spontaneous speech conditions yielding a measure of fluency improvement. Voxel-wise lesion-symptom mapping (VLSM) was used to relate the number of different words per minute for spontaneous speech, SE, and SE-related improvement to patterns of brain damage in order to predict lesion locations associated with the fluency-inducing response to SE. Individuals with Broca's aphasia demonstrated a significant increase in different words per minute during SE versus spontaneous speech. A similar pattern of improvement was not seen in patients with other types of aphasia. VLSM analysis revealed damage to the inferior frontal gyrus predicted this response. Results suggest that SE exerts its fluency-inducing effects by providing a surrogate target for speech production via internal monitoring processes. Clinically, these results add further support for the use of SE to improve speech production and may help select patients for SE treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Syringes versus minibags as an intravenous admixture system: a comparison of cost and nursing preference.

    PubMed

    Gin, A; Martens, D; Dobson, K; Hall, K

    1987-06-01

    The implementation of centralized intravenous admixture programs in Canadian hospitals has been hindered by the high costs associated with such programs. The most popular system uses minibags as an admixture base but other less expensive alternatives are being investigated. This study examines the material and labour costs associated with preparing admixtures in either minibags or polypropylene syringes. The minibag admixtures were administered by nursing staff using secondary medication administration sets. Standard volume-control sets were used for diluting and administering the intravenous admixtures supplied in syringes. The results indicated a major cost advantage for the syringe-based program. Furthermore, evaluation of the two systems by nursing staff indicated a strong preference for the syringe-based system.

  19. The Emerging Role of Admixture in the Pharmacogenetics of Puerto Rican Hispanics

    PubMed Central

    Duconge, Jorge; Ruaño, Gualberto

    2011-01-01

    Admixture is of great relevance to the clinical application of pharmacogenetics and personalized medicine. Preliminary findings in Puerto Ricans further substantiate the argument for admixture as a critical covariate in a customized DNA-guided warfarin dosing algorithm. To this purpose, a genome-wide approach that incorporates admixture as an independent predictor of dose variability in DNA-guided algorithms has been postulated. Admixture is expected to be able to reveal some relevant associations in the genetic epidemiology of Hispanics and will be indispensable to assure that pharmacogenomic research can be pursued in such mixed populations. Consequently, the clinical utility of knowing an individual’s genotype before initiating drug treatment in Puerto Ricans, and Hispanics in general, will finally be untangled by developing a “Genetic Prescription Model” that takes admixture into consideration. This approach will help lead physicians and patients to their desired treatment goal, resulting in more effective healthcare in admixed people. PMID:23227441

  20. Adiposity and genetic admixture, but not race/ethnicity, influence bone mineral content in peripubertal children

    PubMed Central

    Thomas, Olivia; Dulin-Keita, Akilah; Fernandez, Jose R.

    2010-01-01

    The effect of fat mass on bone mineral content (BMC) in children is not clear, particularly when considering a diverse population. Ancestral genetic admixture may be an approach to accurately identify population differences in BMC. Our objective was to evaluate the relationships between self-reported race/ethnicity, genetic admixture, and fat mass on BMC in a multiethnic sample of children (n = 270), taking into account dietary and physical activity variables. Ancestral genetic admixture was estimated using 140 ancestry informative markers, body composition by dual-energy X-ray absorptiometry, diet by 24-h recall, and physical activity by accelerometry. Multiple linear regression examined the relationships between race/ethnicity or genetic admixture and percent fat on BMC. Additional analyses were conducted to examine the relationship between race/ethnicity or genetic admixture and BMC stratified by body fat percentage cutpoints. In regression models, there was no association between race/ethnicity and BMC. In contrast, African admixture (AFADM) was positively associated with BMC, American Indian admixture (AMINADM) was inversely associated with BMC, and there was no association between European admixture (EUADM) and BMC. When stratified by percent fat group, high body fat percentage was inversely associated with BMC with EUADM and AMINADM (P = 0.03 and P = 0.02, respectively) and positively associated with AFADM (P < 0.001). Diet and physical activity were not related to BMC in this sample. Our findings suggest that genetic admixture and percent body fat, but not race/ethnicity, diet, or physical activity, influence BMC in our sample of peripubertal children. Further, there is a differential impact of percent fat on BMC that may be mediated by genetic admixture. PMID:20087611

  1. Wood entrainment factors analysis using a fixed flume experiment

    NASA Astrophysics Data System (ADS)

    Chen, Su-Chin; Chao, Yi-Chiung; Wang, Ci-Rong

    2013-04-01

    The dynamical mechanism of wood debris entrainment is a complex behavior in the natural river. We, thus, used a fixed flume experiment and simplified some complex impacts to simulate the individual wood entrainment. Using different woody characteristics, such as different lengths (15~30 cm), diameters (3~5 cm) and densities (428 ~1142 kg/m3) of wood, and the flow angles between the wood and the central flow, such as parallel, oblique, and transverse, and bed roughness (5 and 8 mm) to explore the influences for the flow surrounding the wood. The results indicated that wood diameters and densities are the key factors to keep the wood debris stable; special, the wood density had the effect significantly. In addition, the other factor affected wood to keep stability in the channel was the flow angle between the wood. Wood entrainment has a interaction with buoyant force significantly and drag force unobtrusively as the wood paralleling the flow. Following the depth increases gradually, the buoyant force development and the friction force decrease until the wood start to entrain by semi-floating and semi-sliding. The drag force drove wood to entrain as the wood was oblique or transverse to the flow. The drag force and channel bed roughness had a positive relationship in this case. While the wood accessed greater channel bed roughness, the wood entrainment needed more drag force to rolling to the downstream. Summarized the results, we used regression analysis to show significant models of the wood entrainment. The model established Y* (the relative buoyancy), X* (the normalized ratio of the drag force and resistance to movement of the log), and used wood densities to distinguish four different wood entrainment thresholds (300~600 kg/m3, 600~800 kg/m3, 800~1000 kg/m3, and >1000 kg/m3). With the wood densities increasing, the wood entrainment thresholds are reducing slightly. Finally, we hope that these results could provide accessible principles to predict the wood

  2. Disordered speech disrupts conversational entrainment: a study of acoustic-prosodic entrainment and communicative success in populations with communication challenges

    PubMed Central

    Borrie, Stephanie A.; Lubold, Nichola; Pon-Barry, Heather

    2015-01-01

    Conversational entrainment, a pervasive communication phenomenon in which dialogue partners adapt their behaviors to align more closely with one another, is considered essential for successful spoken interaction. While well-established in other disciplines, this phenomenon has received limited attention in the field of speech pathology and the study of communication breakdowns in clinical populations. The current study examined acoustic-prosodic entrainment, as well as a measure of communicative success, in three distinctly different dialogue groups: (i) healthy native vs. healthy native speakers (Control), (ii) healthy native vs. foreign-accented speakers (Accented), and (iii) healthy native vs. dysarthric speakers (Disordered). Dialogue group comparisons revealed significant differences in how the groups entrain on particular acoustic–prosodic features, including pitch, intensity, and jitter. Most notably, the Disordered dialogues were characterized by significantly less acoustic-prosodic entrainment than the Control dialogues. Further, a positive relationship between entrainment indices and communicative success was identified. These results suggest that the study of conversational entrainment in speech pathology will have essential implications for both scientific theory and clinical application in this domain. PMID:26321996

  3. Disordered speech disrupts conversational entrainment: a study of acoustic-prosodic entrainment and communicative success in populations with communication challenges.

    PubMed

    Borrie, Stephanie A; Lubold, Nichola; Pon-Barry, Heather

    2015-01-01

    Conversational entrainment, a pervasive communication phenomenon in which dialogue partners adapt their behaviors to align more closely with one another, is considered essential for successful spoken interaction. While well-established in other disciplines, this phenomenon has received limited attention in the field of speech pathology and the study of communication breakdowns in clinical populations. The current study examined acoustic-prosodic entrainment, as well as a measure of communicative success, in three distinctly different dialogue groups: (i) healthy native vs. healthy native speakers (Control), (ii) healthy native vs. foreign-accented speakers (Accented), and (iii) healthy native vs. dysarthric speakers (Disordered). Dialogue group comparisons revealed significant differences in how the groups entrain on particular acoustic-prosodic features, including pitch, intensity, and jitter. Most notably, the Disordered dialogues were characterized by significantly less acoustic-prosodic entrainment than the Control dialogues. Further, a positive relationship between entrainment indices and communicative success was identified. These results suggest that the study of conversational entrainment in speech pathology will have essential implications for both scientific theory and clinical application in this domain.

  4. Turning Off Entrainment: The Role of Particle Size Distributions and Vent GeometryIn The Collapse of Volcanic Jets

    NASA Astrophysics Data System (ADS)

    Jessop, D.; Jellinek, M.; Roche, O.

    2014-12-01

    Volcanic jets can undergo gravitational collapse to produce pyroclastic density currents (PDCs), or loft material several tens of kilometres and spread out as an ash cloud. The key ingredient that determines which of these two phenomena will occur is the turbulent entrainment of atmospheric air, which adds buoyancy to the jet. Classical models of eruption columns assume that the rate of entrainment is fixed and ~10% of the upflow rate of the jet. In particular, the efficiency of entrainment is assumed to be independent of the vent shape as well as the physical properties of the pyroclastic mixture. However, we show that the presence of particles of certain particle-size distributions (PSDs) in the jet can have a significant effect on the entrainment rate owing to their buoyancy and inertia. As a consequence, the conditions for collapse as previously identified must be revisited. In particular, there is a possibility for an eruption to produce both a buoyant column and a collapsing fountain. Using scaled analogue experiments, we test the likelyhood of collapse and the production of pyroclastic flows according to the source geometry and particle-size distributions.

  5. Final Report - "Foaming and Antifoaming and Gas Entrainment in Radioactive Waste Pretreatment and Immobilization Processes"

    SciTech Connect

    Wasan, Darsh T.

    2007-10-09

    The Savannah River Site (SRS) and Hanford site are in the process of stabilizing millions of gallons of radioactive waste slurries remaining from production of nuclear materials for the Department of Energy (DOE). The Defense Waste Processing Facility (DWPF) at SRS is currently vitrifying the waste in borosilicate glass, while the facilities at the Hanford site are in the construction phase. Both processes utilize slurry-fed joule-heated melters to vitrify the waste slurries. The DWPF has experienced difficulty during operations. The cause of the operational problems has been attributed to foaming, gas entrainment and the rheological properties of the process slurries. The rheological properties of the waste slurries limit the total solids content that can be processed by the remote equipment during the pretreatment and meter feed processes. Highly viscous material can lead to air entrainment during agitation and difficulties with pump operations. Excessive foaming in waste evaporators can cause carryover of radionuclides and non-radioactive waste to the condensate system. Experimental and theoretical investigations of the surface phenomena, suspension rheology and bubble generation of interactions that lead to foaming and air entrainment problems in the DOE High Level and Low Activity Radioactive Waste separation and immobilization processes were pursued under this project. The first major task accomplished in the grant proposal involved development of a theoretical model of the phenomenon of foaming in a three-phase gas-liquid-solid slurry system. This work was presented in a recently completed Ph.D. thesis (9). The second major task involved the investigation of the inter-particle interaction and microstructure formation in a model slurry by the batch sedimentation method. Both experiments and modeling studies were carried out. The results were presented in a recently completed Ph.D. thesis. The third task involved the use of laser confocal microscopy to study

  6. Improving ENSO periodicity simulation by adjusting cumulus entrainment in BCC_CSMs

    NASA Astrophysics Data System (ADS)

    Lu, Bo; Ren, Hong-Li

    2016-12-01

    The simulation of El Niño-Southern Oscillation (ENSO) phenomenon is a challenging issue for coupled climate models. This study focuses on the ENSO periodicity simulated by Beijing Climate Center Climate System Models (BCC_CSM1.1 and BCC_CSM1.1m) which can reproduce reasonably well ENSO amplitude as observations. However, the major period of ENSO simulated by the BCC_CSMs is around 2.4 years, which is much shorter than that in observations. Compared with other 24 coupled models in Coupled Model Intercomparison Project Phase 5 (CMIP5), BCC_CSMs produce a very unrealistic ENSO peak period. Such a bias in simulating periodicity is suggested as a consequence of the severely underestimated air-sea coupling intensity in BCC_CSMs. To test this hypothesis, a quantitative method is developed to diagnose the linear ENSO frequency. As an effort to improve the ENSO simulation in BCC_CSMs, three experiments are performed with varying entrainment rates in the cumulus convection parameterization scheme of BCC_CSM1.1m. A more realistic ENSO period of about 3.3 years can be generated by the model with an inflated entrainment rate. When the cumulus entrainment is increased by 10%, the ENSO-related convective precipitation will enhance in the equatorial central to eastern Pacific. This anomalous convective heating induces an intensified surface westerly wind stress to the west of the anomalous convection center and as a result, the air-sea coupling intensity becomes larger, which contributes to a longer period of ENSO based on previous theories. In addition, the pronounced eastward extension of ENSO-related surface wind stress could also be the secondary factor to generate a lower frequency of ENSO in BCC_CSMs. Our study proposes a method to reduce the biases in ENSO periodicity simulation and puts more insights into the importance of adjusting atmospheric convection to reproduce ENSO properties in coupled model.

  7. Entrainment and deposition modeling of liquid films with applications for BWR fuel rod dryout

    NASA Astrophysics Data System (ADS)

    Ratnayake, Ruwan Kumara

    While best estimate computer codes provide the licensing basis for nuclear power facilities, they also serve as analytical tools in overall plant and component design procedures. An ideal best estimate code would comprise of universally applicable mechanistic models for all its components. However, due to the limited understanding in these specific areas, many of the models and correlations used in these codes reflect high levels of empiricism. As a result, the use of such models is strictly limited to the range of parameters within which the experiments have been conducted. Disagreements between best estimate code predictions and experimental results are often explained by the mechanistic inadequacies of embedded models. Significant mismatches between calculated and experimental critical power values are common observations in the analyses of Boiling Water Reactors (BWR). Based on experimental observations and calculations, these mismatches are attributed to the additional entrainment and deposition caused by spacer grids in BWR fuel assemblies. In COBRA-TF (Coolant Boiling in Rod Arrays-Two Fluid); a state of the art industrial best estimate code, these disagreements are hypothesized to occur due the absence of an appropriate spacer grid model. In this thesis, development of a suitably detailed spacer grid model and integrating it to COBRA-TF is documented. The new spacer grid model is highly mechanistic so that the applicability of it is not seriously affected by geometric variations in different spacer grid designs. COBRA-TF (original version) simulations performed on single tube tests and BWR rod bundles with spacer grids showed that single tube predictions were more accurate than those of the rod bundles. This observation is understood to arise from the non-availability of a suitable spacer grid model in COBRA-TF. Air water entrainment experiments were conducted in a test section simulating two adjacent BWR sub channels to visualize the flow behavior at

  8. Chimpanzee genomic diversity reveals ancient admixture with bonobos.

    PubMed

    de Manuel, Marc; Kuhlwilm, Martin; Frandsen, Peter; Sousa, Vitor C; Desai, Tariq; Prado-Martinez, Javier; Hernandez-Rodriguez, Jessica; Dupanloup, Isabelle; Lao, Oscar; Hallast, Pille; Schmidt, Joshua M; Heredia-Genestar, José María; Benazzo, Andrea; Barbujani, Guido; Peter, Benjamin M; Kuderna, Lukas F K; Casals, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe; Kühl, Hjalmar; Vigilant, Linda; Langergraber, Kevin; Novembre, John; Gut, Marta; Gut, Ivo; Navarro, Arcadi; Carlsen, Frands; Andrés, Aida M; Siegismund, Hans R; Scally, Aylwyn; Excoffier, Laurent; Tyler-Smith, Chris; Castellano, Sergi; Xue, Yali; Hvilsom, Christina; Marques-Bonet, Tomas

    2016-10-28

    Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution. Copyright © 2016, American Association for the Advancement of Science.

  9. Strength characteristics of light weight concrete blocks using mineral admixtures

    NASA Astrophysics Data System (ADS)

    Bhuvaneshwari, P.; Priyadharshini, U.; Gurucharan, S.; Mithunram, B.

    2017-07-01

    This paper presents an experimental study to investigate the characteristics of light weight concrete blocks. Cement was partially replaced with mineral admixtures like Fly ash (FA), limestone powder waste (LPW), Rice husk ash (RHA), sugarcane fiber waste (SCW) and Chrysopogonzizanioides (CZ). The maximum replacement level achieved was 25% by weight of cement and sand. Total of 56 cubes (150 mm x 150 mm x150 mm) and 18 cylinders (100mmφ and 50mm depth) were cast. The specimens being (FA, RHA, SCW, LPW, CZ, (FA-RHA), (FA-LPW), (FA-CZ), (LPW-CZ), (FA-SCW), (RHA-SCW)).Among the different combination, FA,FA-SCW,CZ,FA-CZ showed enhanced strength and durability, apart from achieving less density.

  10. Impact of admixtures on the hydration kinetics of Portland cement

    SciTech Connect

    Cheung, J.; Jeknavorian, A.; Roberts, L.; Silva, D.

    2011-12-15

    Most concrete produced today includes either chemical additions to the cement, chemical admixtures in the concrete, or both. These chemicals alter a number of properties of cementitious systems, including hydration behavior, and it has been long understood by practitioners that these systems can differ widely in response to such chemicals. In this paper the impact on hydration of several classes of chemicals is reviewed with an emphasis on the current understanding of interactions with cement chemistry. These include setting retarders, accelerators, and water reducing dispersants. The ability of the chemicals to alter the aluminate-sulfate balance of cementitious systems is discussed with a focus on the impact on silicate hydration. As a key example of this complex interaction, unusual behavior sometimes observed in systems containing high calcium fly ash is highlighted.

  11. Used cooking oil as a green chemical admixture in concrete

    NASA Astrophysics Data System (ADS)

    Salmia, B.; Che Muda, Zakaria; Ashraful Alam, Md; Sidek, L. M.; Hidayah, B.

    2013-06-01

    According to National Statistics Approximately 1.35 billion gallons of used oil are generated yearly. With the increasing of the concrete usage, a more cost effective and economic new type of admixtures may give positive impacts on the Malaysian construction building as well as worldwide concrete usage. To objective of this is study is to investigate the effect of used cooking oil in terms of slump test, compressive strength test and rebound hammer. By adding the used cooking oil to the concrete, it increases the slump value from 4% to 72%. And the compressive strength have an increment from 1% to 16.8%. The used cooking oil obtains the optimum contribution to the concrete mix proportion of containing used cooking oil of 1.50% from the cement content. The result of used cooking oil from experimental program of slump value and compressive strength proved that used cooking oil have positive effects on replacement of commercially available superplasticizer.

  12. Migration, genetic markers and race admixture in Curitiba, Brazil.

    PubMed

    Culpi, L; Salzano, F M

    1984-01-01

    1000 Blacks and 1001 Whites from the southern Brazilian city Curitiba were studied in relation to migration patterns, ABO and Rh blood groups, and hemoglobin types. Despite a lower socioeconomic level, Blacks migrated more than Whites. Carriers of abnormal hemoglobin types show about the same degree of mobility as those with normal hemoglobin only. As much as 1/2 of the genes present among the Blacks of this city may be of European origin, while persons classified as White may have from 3 to 19% of African ancestry. The results are in agreement with the history of the community and indicate that the process of race admixture is occurring at a high rate despite the relatively low frequency of individuals showing clear signs of African ancestry (as compared the bulk of the Brazilian populations) in Curitiba.

  13. Testing Central and Inner Asian admixture among contemporary Hungarians.

    PubMed

    Bíró, András; Fehér, Tibor; Bárány, Gusztáv; Pamjav, Horolma

    2015-03-01

    Historically, the Carpathian Basin was the final destination for many nomadic peoples who migrated westward from Inner and Central Asia towards Europe. Proto-Hungarians (Steppe Magyars) were among those who came from the East, the Eurasian Steppe in the early middle ages. In order to detect the paternal genetic contribution from nomadic Steppe tribes, we tested 966 samples from Central Asian (Uzbekistan, Kazakhstan), Inner Asian (Mongolians and Buryats in Mongolia) and Hungarian-speaking European (Hungarian, Sekler and Csango) populations. We constructed median-joining networks of certain haplogroups in Hungarian-speaking European, and Altaic-speaking Central and Inner Asian populations. We estimated that the possible paternal genetic contribution from the above described populations among contemporary Hungarian speaking populations ranged between 5% and 7.4%. It is lowest among Hungarians from Hungary (5.1%), while higher among Hungarian-speaking groups in Romania, notably Sekler (7.4%) and Csango (6.3%). However, these results represent only an upper limit. Actual Central/Inner Asian admixture might be somewhat lower as some of the related lineages may have come from a common third source. The main haplogroups responsible for the Central/Inner Asian admixture among Hungarians are J2*-M172 (xM47, M67, M12), J2-L24, R1a-Z93; Q-M242 and E-M78. Earlier studies showed very limited Uralic genetic influence among Hungarians, and based on the present study, Altaic/Turkic genetic contribution is also not significant, although significantly higher than the Uralic one. The conclusion of this study is that present-day Hungarian speakers are genetically very similar to neighbouring populations, isolated Hungarian speaking groups having relatively higher presence of Central and Inner Asian genetic elements. At the same time, the reliable historical and genetic conclusions require an extension of the study to a significantly larger database with deep haplogroup resolution

  14. Effects of Temperature and Humidity upon the Entrainment of Sedimentary Particles by Wind

    NASA Astrophysics Data System (ADS)

    McKenna Neuman, Cheryl

    Aeolian transport of sedimentary particles is a well-recognized phenomenon in cold regions, but the effect of low temperature (T) and specific humidity (q) upon particle entrainment has not previously been investigated. This study reports on wind-tunnel experiments (-12 °C T 32 °C, and 1 g kg-1 q 10 g kg-1) that suggest the aerodynamic drag required to entrain sand sized particles can be 30% lower in cold or high latitude settings, as compared to hot deserts. For any given regional wind velocity, this effect will increase the wind strength index and thereby the proportion of time a surface is active at low temperature.The influence of air temperature and humidity upon the threshold for particle motion is determined by three physical processes: (1) The effect of air viscosity and density on the fluid drag force acting to dislodge sedimentary particles; (2) the effect of viscosity on the turbulent wake shed from these particles, and the frequency and magnitude of burst-sweep events; and (3) the development of inter-particle cohesion via adsorbed water. This study considers the relative importance of each of these processes. The threshold friction velocity model of Shao and Lu is revised to incorporate the inter-particle force associated with hygroscopic water. It is found to perform well when tested against the experimental data obtained for this study.

  15. Influence of cross-flow on the entrainment of bending plumes

    NASA Astrophysics Data System (ADS)

    Freedland, Graham; Mastin, Larry; Steven, Solovitz; Cal, Raul

    2016-11-01

    Volcanic eruption columns inject high concentrations of ash into the atmosphere. Some of this ash is carried downwind forming ash clouds in the atmosphere that are hazardous for private and commercial aviation. Current models rely on inputs such as plume height, duration, eruption rate, and meteorological wind fields. Eruption rate is estimated from plume height using relations that depend on the rate of air entrainment into the plume, which is not well quantified. A wind tunnel experiment has been designed to investigate these models by injecting a vertical air jet into a cross-flow. The ratio of the cross-flow and jet velocities is varied to simulate a weak plume, and flow response is measured using particle image velocimetry. The plumes are characterized and profile data is examined to measure the growth of weak plumes and the entrainment velocity along its trajectory. This allows for the study of the flow field, mean, and second order moments, and obtain information to improve models of volcanic ash concentrations in the atmosphere.

  16. The relationship between European genetic admixture and body composition among Hispanics and Native Americans.

    PubMed

    Klimentidis, Y C; Miller, G F; Shriver, M D

    2009-01-01

    Previous studies have shown a relationship between health-related phenotypes and the degree of African, European, or Native American genetic admixture, indicating that there may be a genetic component to these phenotypes. However, these relationships may be driven to a large extent by the environmental differences that co-vary with admixture differences between and within groups. In this study, we examine the relationship between genetic admixture and two phenotypic measurements that are potentially related to health: body mass index (BMI) and percent body fat (PBF). In addition to admixture proportions, we attempt to assess the influence of some environmental covariates by examining how the phenotypes vary with self-reported household income, education of parents, and physical activity level. Genetic, anthropometric, and environmental data were collected from 170 self-reported Hispanic and Native American university students in Albuquerque, NM. We examine the relationships between genetic admixture, phenotype, and environment in both the full sample, as well as in Hispanics and Native Americans separately. Among Hispanics, we find no significant relationship between genetic admixture and body composition. Among Native Americans, despite a small sample size, we find a statistically significant, negative relationship between European genetic admixture and PBF and BMI, after adjusting for other predictor variables. We compare our findings to previous research, and discuss their implications for understanding health disparities within and between ethnic groups.

  17. The Complex Admixture History and Recent Southern Origins of Siberian Populations

    PubMed Central

    Pugach, Irina; Matveev, Rostislav; Spitsyn, Viktor; Makarov, Sergey; Novgorodov, Innokentiy; Osakovsky, Vladimir; Stoneking, Mark; Pakendorf, Brigitte

    2016-01-01

    Although Siberia was inhabited by modern humans at an early stage, there is still debate over whether it remained habitable during the extreme cold of the Last Glacial Maximum or whether it was subsequently repopulated by peoples with recent shared ancestry. Previous studies of the genetic history of Siberian populations were hampered by the extensive admixture that appears to have taken place among these populations, because commonly used methods assume a tree-like population history and at most single admixture events. Here we analyze geogenetic maps and use other approaches to distinguish the effects of shared ancestry from prehistoric migrations and contact, and develop a new method based on the covariance of ancestry components, to investigate the potentially complex admixture history. We furthermore adapt a previously devised method of admixture dating for use with multiple events of gene flow, and apply these methods to whole-genome genotype data from over 500 individuals belonging to 20 different Siberian ethnolinguistic groups. The results of these analyses indicate that there have been multiple layers of admixture detectable in most of the Siberian populations, with considerable differences in the admixture histories of individual populations. Furthermore, most of the populations of Siberia included here, even those settled far to the north, appear to have a southern origin, with the northward expansions of different populations possibly being driven partly by the advent of pastoralism, especially reindeer domestication. These newly developed methods to analyze multiple admixture events should aid in the investigation of similarly complex population histories elsewhere. PMID:26993256

  18. Extraordinary behavioral entrainment following circadian rhythm bifurcation in mice.

    PubMed

    Harrison, Elizabeth M; Walbeek, Thijs J; Sun, Jonathan; Johnson, Jeremy; Poonawala, Qays; Gorman, Michael R

    2016-12-08

    The mammalian circadian timing system uses light to synchronize endogenously generated rhythms with the environmental day. Entrainment to schedules that deviate significantly from 24 h (T24) has been viewed as unlikely because the circadian pacemaker appears capable only of small, incremental responses to brief light exposures. Challenging this view, we demonstrate that simple manipulations of light alone induce extreme plasticity in the circadian system of mice. Firstly, exposure to dim nocturnal illumination (<0.1 lux), rather than completely dark nights, permits expression of an altered circadian waveform wherein mice in light/dark/light/dark (LDLD) cycles "bifurcate" their rhythms into two rest and activity intervals per 24 h. Secondly, this bifurcated state enables mice to adopt stable activity rhythms under 15 or 30 h days (LDLD T15/T30), well beyond conventional limits of entrainment. Continuation of dim light is unnecessary for T15/30 behavioral entrainment following bifurcation. Finally, neither dim light alone nor a shortened night is sufficient for the extraordinary entrainment observed under bifurcation. Thus, we demonstrate in a non-pharmacological, non-genetic manipulation that the circadian system is far more flexible than previously thought. These findings challenge the current conception of entrainment and its underlying principles, and reveal new potential targets for circadian interventions.

  19. Entrainment of a Bacterial Synthetic Gene Oscillator through Proteolytic Queueing.

    PubMed

    Butzin, Nicholas C; Hochendoner, Philip; Ogle, Curtis T; Mather, William H

    2017-03-17

    Internal chemical oscillators (chemical clocks) direct the behavior of numerous biological systems, and maintenance of a given period and phase among many such oscillators may be important for their proper function. However, both environmental variability and fundamental molecular noise can cause biochemical oscillators to lose coherence. One solution to maintaining coherence is entrainment, where an external signal provides a cue that resets the phase of the oscillators. In this work, we study the entrainment of gene networks by a queueing interaction established by competition between proteins for a common proteolytic pathway. Principles of queueing entrainment are investigated for an established synthetic oscillator in Escherichia coli. We first explore this theoretically using a standard chemical reaction network model and a map-based model, both of which suggest that queueing entrainment can be achieved through pulsatile production of an additional protein competing for a common degradation pathway with the oscillator proteins. We then use a combination of microfluidics and fluorescence microscopy to verify that pulse trains modulating the production rate of a fluorescent protein targeted to the same protease (ClpXP) as the synthetic oscillator can entrain the oscillator.

  20. Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles

    PubMed Central

    Sládek, Martin; Sumová, Alena

    2013-01-01

    The functional state of the circadian system of spontaneously hypertensive rats (SHR) differs in several characteristics from the functional state of normotensive Wistar rats. Some of these changes might be due to the compromised ability of the central pacemaker to entrain the peripheral clocks. Daily body temperature cycles represent one of the important cues responsible for the integrity of the circadian system, because these cycles are driven by the central pacemaker and are able to entrain the peripheral clocks. This study tested the hypothesis that the aberrant peripheral clock entrainment of SHR results from a compromised peripheral clock sensitivity to the daily temperature cycle resetting. Using cultured Wistar rat and SHR fibroblasts transfected with the circadian luminescence reporter Bmal1-dLuc, we demonstrated that two consecutive square-wave temperature cycles with amplitudes of 2.5°C are necessary and sufficient to restart the dampened oscillations and entrain the circadian clocks in both Wistar rat and SHR fibroblasts. We also generated a phase response curve to temperature cycles for fibroblasts of both rat strains. Although some of the data suggested a slight resistance of SHR fibroblasts to temperature entrainment, we concluded that the overall effect it too weak to be responsible for the differences between the SHR and Wistar in vivo circadian phenotype. PMID:24116198

  1. Simulating entrainment and particle fluxes in stratified estuaries

    SciTech Connect

    Jensen, A.; Jirka, G.; Lion, L.W.; Brunk, B.

    1999-04-01

    Settling and entrainment are the dominant processes governing noncohesive particle concentration throughout the water column of salt-wedge estuaries. Determination of the relative contribution of these transport processes is complicated by vertical gradients in turbulence and fluid density. A differential-turbulence column (DTC) was designed to simulate a vertical section of a natural water column. With satisfactory characterization of turbulence dissipation and saltwater entrainment, the DTC facilitates controlled studies of suspended particles under estuarine conditions. The vertical decay of turbulence in the DTC was found to obey standard scaling law relations when the characteristic length scale for turbulence in the apparatus was incorporated. The entrainment rate of a density interface also followed established grid-stirred turbulence scaling laws. These relations were used to model the change in concentration of noncohesive particles above a density interface. Model simulations and experimental data from the DTC were consistent over the range of conditions encountered in natural salt-wedge estuaries. Results suggest that when the ratio of entrainment rate to particle settling velocity is small, sedimentation is the dominant transport process, while entrainment becomes significant as the ratio increases.

  2. Extraordinary behavioral entrainment following circadian rhythm bifurcation in mice

    PubMed Central

    Harrison, Elizabeth M.; Walbeek, Thijs J.; Sun, Jonathan; Johnson, Jeremy; Poonawala, Qays; Gorman, Michael R.

    2016-01-01

    The mammalian circadian timing system uses light to synchronize endogenously generated rhythms with the environmental day. Entrainment to schedules that deviate significantly from 24 h (T24) has been viewed as unlikely because the circadian pacemaker appears capable only of small, incremental responses to brief light exposures. Challenging this view, we demonstrate that simple manipulations of light alone induce extreme plasticity in the circadian system of mice. Firstly, exposure to dim nocturnal illumination (<0.1 lux), rather than completely dark nights, permits expression of an altered circadian waveform wherein mice in light/dark/light/dark (LDLD) cycles “bifurcate” their rhythms into two rest and activity intervals per 24 h. Secondly, this bifurcated state enables mice to adopt stable activity rhythms under 15 or 30 h days (LDLD T15/T30), well beyond conventional limits of entrainment. Continuation of dim light is unnecessary for T15/30 behavioral entrainment following bifurcation. Finally, neither dim light alone nor a shortened night is sufficient for the extraordinary entrainment observed under bifurcation. Thus, we demonstrate in a non-pharmacological, non-genetic manipulation that the circadian system is far more flexible than previously thought. These findings challenge the current conception of entrainment and its underlying principles, and reveal new potential targets for circadian interventions. PMID:27929128

  3. Effect of Mixing Time and Storage Condition on Characterization of Heparinoid Admixtures with Corticosteroids.

    PubMed

    Sugiyama, Ikumi; Takahashi, Namiki; Sadzuka, Yasuyuki

    2016-01-01

     In dermatologic therapy, several external preparations formulated as ointments or creams are prescribed. And they are often admixture to improve patient compliance. In this study, we prepared admixtures of moisturizer with steroids and examined their usability and the amount of principal agent in formulations, particularly focusing on the moisturizer content. Four heparinoid semisolid formulations were selected: Hirudoid(®) soft ointment 0.3% (Formulation A) and 3 generic agents [(Besoften(®) oil-based cream 0.3% (Formulation B), Kuradoido(®) ointment 0.3% (Formulation C), and Hepadaerm ointment 0.3% (Formulation D)], and Antebate(®) ointment 0.05% (Formulation E) were used as steroids. Formulation A and B are water-in-oil emulsions, and Formulation C and D are oil-in-water emulsions. Admixtures looked like to be mixed uniformly by visual observation. In the examination of heparinoid amount, admixture A+E and B+E were mixed uniformly. On the other hand, admixture C+E was remarkable un-uniformly. It was speculated that the emulsification of formulation C was broken. The phenomenon was supported by the result of malleability. After 8 weeks storage, the heparinoid ratio in each formulation could be expressed as follows: Admixture B≥Admixture A>Admixture C=Admixture D. A suitable storage temperature was 4°C. The results of physicochemical data analysis reveal the formulations composed of water-in-oil cream, i.e., Formulation A and Formulation B, to be the optimal choices for mixing with steroid ointments. Mixing time and storage conditions may be optimized to solve pharmaceutical problems. Moreover, understanding the emulsion type and character of semisolid formulations can expand the range of formulation options.

  4. Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women

    PubMed Central

    Qi, L.; Nassir, R.; Kosoy, R.; Garcia, L.; Curb, J. D.; Tinker, L.; Howard, B. V.; Robbins, J.; Seldin, M. F.

    2015-01-01

    Aims/hypothesis Type 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups. Methods We estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476 AFA and HA women from the Women's Health Initiative. Cox regression models were used to examine the association between admixture and diabetes risk, with and without accounting for socioeconomic status (SES) and adiposity measurements. Results AFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age, neighbourhood SES and BMI or waist/hip ratio (WHR) (all p<0.0001). In HA women, AMI admixture had significant associations with diabetes risk that remained significant after adjustment for SES and BMI (all p<0.0005). In both AFAs and HAs, SES showed significant negative associations while BMI or WHR had significant positive associations with diabetes risk, with and without adjustment for genetic admixture. Conclusions/interpretation In AFAs, admixture, SES and BMI/WHR each independently contribute to diabetes risk after accounting for each of the other factors; in HAs, admixture, SES and BMI each independently contribute to diabetes risk after accounting for each of the other factors, whereas admixture is not significantly associated with diabetes risk after accounting for SES and WHR. The findings emphasise the importance of considering both genetic and environmental causes in the aetiology of type 2 diabetes. PMID:22322919

  5. Population admixture, biological invasions and the balance between local adaptation and inbreeding depression.

    PubMed

    Verhoeven, Koen J F; Macel, Mirka; Wolfe, Lorne M; Biere, Arjen

    2011-01-07

    When previously isolated populations meet and mix, the resulting admixed population can benefit from several genetic advantages, including increased genetic variation, the creation of novel genotypes and the masking of deleterious mutations. These admixture benefits are thought to play an important role in biological invasions. In contrast, populations in their native range often remain differentiated and frequently suffer from inbreeding depression owing to isolation. While the advantages of admixture are evident for introduced populations that experienced recent bottlenecks or that face novel selection pressures, it is less obvious why native range populations do not similarly benefit from admixture. Here we argue that a temporary loss of local adaptation in recent invaders fundamentally alters the fitness consequences of admixture. In native populations, selection against dilution of the locally adapted gene pool inhibits unconstrained admixture and reinforces population isolation, with some level of inbreeding depression as an expected consequence. We show that admixture is selected against despite significant inbreeding depression because the benefits of local adaptation are greater than the cost of inbreeding. In contrast, introduced populations that have not yet established a pattern of local adaptation can freely reap the benefits of admixture. There can be strong selection for admixture because it instantly lifts the inbreeding depression that had built up in isolated parental populations. Recent work in Silene suggests that reduced inbreeding depression associated with post-introduction admixture may contribute to enhanced fitness of invasive populations. We hypothesize that in locally adapted populations, the benefits of local adaptation are balanced against an inbreeding cost that could develop in part owing to the isolating effect of local adaptation itself. The inbreeding cost can be revealed in admixing populations during recent invasions.

  6. Population admixture, biological invasions and the balance between local adaptation and inbreeding depression

    PubMed Central

    Verhoeven, Koen J. F.; Macel, Mirka; Wolfe, Lorne M.; Biere, Arjen

    2011-01-01

    When previously isolated populations meet and mix, the resulting admixed population can benefit from several genetic advantages, including increased genetic variation, the creation of novel genotypes and the masking of deleterious mutations. These admixture benefits are thought to play an important role in biological invasions. In contrast, populations in their native range often remain differentiated and frequently suffer from inbreeding depression owing to isolation. While the advantages of admixture are evident for introduced populations that experienced recent bottlenecks or that face novel selection pressures, it is less obvious why native range populations do not similarly benefit from admixture. Here we argue that a temporary loss of local adaptation in recent invaders fundamentally alters the fitness consequences of admixture. In native populations, selection against dilution of the locally adapted gene pool inhibits unconstrained admixture and reinforces population isolation, with some level of inbreeding depression as an expected consequence. We show that admixture is selected against despite significant inbreeding depression because the benefits of local adaptation are greater than the cost of inbreeding. In contrast, introduced populations that have not yet established a pattern of local adaptation can freely reap the benefits of admixture. There can be strong selection for admixture because it instantly lifts the inbreeding depression that had built up in isolated parental populations. Recent work in Silene suggests that reduced inbreeding depression associated with post-introduction admixture may contribute to enhanced fitness of invasive populations. We hypothesize that in locally adapted populations, the benefits of local adaptation are balanced against an inbreeding cost that could develop in part owing to the isolating effect of local adaptation itself. The inbreeding cost can be revealed in admixing populations during recent invasions. PMID

  7. Organization of tropical convection in low vertical wind shears: Role of updraft entrainment

    NASA Astrophysics Data System (ADS)

    Tompkins, Adrian M.; Semie, Addisu G.

    2017-06-01

    Radiative-convective equilibrium simulations with a 2 km horizontal resolution are conducted to investigate the impact on convective organization of different parameterizations for horizontal and vertical subgrid turbulence mixing. Three standard approaches for representing horizontal diffusion produce starkly differing mixing rates, particularly for the entrainment mixing into updrafts, which differ by more than an order of magnitude between the schemes. The simulations demonstrate that the horizontal subgrid mixing of water vapor is key, with high mixing rates a necessary condition for organization of convection to occur, since entrainment of dry air into updrafts suppresses convection. It is argued that diabatic budgets, while demonstrating the role of spatially heterogeneous radiative heating rates in driving organization, can overlook the role of physical processes such as updraft entrainment. These results may partially explain previous studies that showed that organization is more likely to occur at coarser resolutions, when entrainment is solely represented by subgrid-scale turbulence schemes, highlighting the need for benchmark simulations of higher horizontal resolution. The recommendation is for the use of larger ensembles to ensure robustness of conclusions to subgrid-scale parameterization assumptions when numerically investigating convective organization, possibly through a coordinated community model intercomparison effort.Plain Language SummaryThunderstorms dry out the atmosphere since they produce rainfall. However, their efficiency at drying the atmosphere depends on how they are arranged; take a set of thunderstorms and sprinkle them randomly over the tropics and the troposphere will remain quite moist, but take that same number of thunderstorms and place them all close together in a "cluster" and the atmosphere will be much drier. Previous work has indicated that thunderstorms might start to cluster</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2006JMiMi..16S.211F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2006JMiMi..16S.211F"><span>Development of a large-<span class="hlt">entrainment</span>-ratio axisymmetric supersonic ejector for micro butane combustor</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fan, Yong; Suzuki, Yuji; Kasagi, Nobuhide</p> <p>2006-09-01</p> <p>A large-<span class="hlt">entrainment</span>-ratio micro ejector has been developed to supply fuel-<span class="hlt">air</span> mixture for a micro butane combustor. As a key component of the ejector, an axisymmetric convergent-divergent supersonic nozzle having a throat diameter of 42 µm is fabricated with high-precision electro-discharge machining. Operating conditions and geometric parameters of the ejector are systematically changed, and their effects on volume-flow-rate ratio are investigated in a series of experiments. Experimental data are compared with analytic solutions and CFD results. It is found that the present micro ejector achieves a maximum <span class="hlt">air</span>-to-butane volume-flow-rate ratio of 43 when the back pressure is 11.6 Pa. It is also found that the present ejector can produce larger volume-flow-rate ratio than the previous MEMS 2D ejector at small back pressure.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734152','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734152"><span>Detecting Ancient <span class="hlt">Admixture</span> and Estimating Demographic Parameters in Multiple Human Populations</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lohmueller, Kirk E.; Plagnol, Vincent</p> <p>2009-01-01</p> <p>We analyze patterns of genetic variation in extant human polymorphism data from the National Institute of Environmental Health Sciences single nucleotide polymorphism project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations) and by explicitly estimating the amount of putative <span class="hlt">admixture</span> between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, and Homo floresiensis). We find evidence for this ancient <span class="hlt">admixture</span> in European, East Asian, and West African samples, suggesting that <span class="hlt">admixture</span> between diverged hominin groups may be a general feature of recent human evolution. PMID:19420049</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008AIPC.1004..170G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008AIPC.1004..170G"><span>Hydration Characteristics of Metakaolin <span class="hlt">Admixtured</span> Cement using DTA, XRD and SEM Techniques</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Govindarajan, D.; Gopalakrishnan, R.</p> <p>2008-04-01</p> <p>The paper aims to investigate hydration and pozzolanic reaction in Portland cement paste with different replacement percentages (0%, 10%, 20% and 30%) of metakaolin. The compressive strength of the metakaolin <span class="hlt">admixtured</span> cement was measured at 1 day, 1 week and 4 weeks. The compressive strength developments of the metakaolin <span class="hlt">admixtured</span> cement are compared with Portland cement. It is found that metakaolin contributes significantly to strength development as an accelerating <span class="hlt">admixture</span> for Portland cement. The pozzolanic reactions and the reaction products were determined by DTA, XRD and SEM.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013JTePh..58..511R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013JTePh..58..511R"><span>Initiation of detonation by a high-voltage discharge in powdered explosives with nanosize inert <span class="hlt">admixtures</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rashkovskii, S. A.; Savenkov, G. G.</p> <p>2013-04-01</p> <p>It is shown that <span class="hlt">admixtures</span> of a copper nanopowder in a high-disperse low-sensitivity explosive of the FOX-7 type sharply increase the sensitivity of the mixture to the action of a high-voltage electric discharge and facilitate detonation. The percolation model of propagation of the electric breakdown over a powdered mixture with nanosize <span class="hlt">admixtures</span> and the model of initiation of detonation by a high-voltage discharge in the mixture of a brisant explosive with an inert <span class="hlt">admixture</span> are developed. These models are in qualitative and quantitative agreement with experimental data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22293488','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22293488"><span>Release profiles of dexamethasone dipropionate from <span class="hlt">admixtures</span> of steroid and heparinoid ointments prepared by different mixing methods.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suzuki, Tsuneyoshi; Uchino, Tomonobu; Miyazaki, Yasunori; Kagawa, Yoshiyuki</p> <p>2012-01-01</p> <p>Characterization and release profiles of commercial dexamethasone dipropionate (DDP) from an innovator and 2 generic ointments (Methaderm (IM), Promethasone (GP), and Mainvate (GM)) and their <span class="hlt">admixtures</span> with heparinoid ointment (Hirudoid Soft) were investigated. The <span class="hlt">admixtures</span> were prepared using 2 mixing methods (slab or rotation/revolution mixer). Microscopic and FT-Raman spectrometric analyses revealed that the ointments, except for IM, contained DDP crystals. A silicone membrane was used for the evaluation of the DDP permeation. The permeated DDP amounts from GP and GM were lower than that from IM, indicating that DDP solubility in the ointment vehicle affected the release of DDP from the ointment. No significant differences were observed in DDP release between IM alone and its <span class="hlt">admixture</span> prepared using a slab; however, DDP release from the <span class="hlt">admixture</span> prepared using a rotation/revolution mixer was significantly lower than those from IM alone and its <span class="hlt">admixture</span> by slab. In the GP system, DDP release from the <span class="hlt">admixtures</span> by the 2 mixing methods was higher than that from GP alone, whereas no significant difference in DDP release between the 2 mixing methods was observed. No significant differences were observed between the GM and <span class="hlt">admixtures</span>. The apparent solubility of DDP in the <span class="hlt">admixtures</span> as determined by the ultracentrifugal separation method indicated that the DDP amount in the liquid phase of <span class="hlt">admixtures</span> with GP was 6 times higher than that of <span class="hlt">admixtures</span> with IM or GM. Therefore, the apparent solubility of DDP in the liquid phase in the GP system might influence the DDP release in <span class="hlt">admixtures</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120001386','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120001386"><span>Aeolian Induced Erosion and Particle <span class="hlt">Entrainment</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Saint, Brandon</p> <p>2007-01-01</p> <p>The Granular Physics Department at The Kennedy Space Center is addressing the problem of erosion on the lunar surface. The early stages of research required an instrument that would produce erosion at a specific rate with a specific sample variation. This paper focuses on the development and experimental procedures to measure and record erosion rates. This was done with the construction of an open <span class="hlt">air</span> wind tunnel, and examining the relationship between airflow and particle motion.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2001APS..MARN23005T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2001APS..MARN23005T"><span>Synchronized Inhibition Boosts Information Transfer in <span class="hlt">Entrained</span> Neurons</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tiesinga, Paul; Fellous, Jean-Marc; Jose, Jorge; Sejnowski, Terrence</p> <p>2001-03-01</p> <p>We investigated the ability of a single neuron to transduce the information content of a synchronized inhibitory synaptic drive, generated by an interneuron network, into an information-rich output of neuron spike times. The neuron was <span class="hlt">entrained</span> to the periodic network drive when the jitter in the input spike times is sufficiently small (i.e. high precision), and the number of presynaptic spikes during one drive cycle is sufficiently large. The Shannon entropy of the output of spike times was reduced sharply during <span class="hlt">entrainment</span>. Surprisingly, however, the amount of transduced information as measured by the mutual information was significantly increased during <span class="hlt">entrainment</span>. This increase was due to the reduced contribution of the internal correlations to the output variability. These theoretical predictions were confirmed in experimental recordings from the rat neocortex and hippocampus.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017RSPTA.37560107A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017RSPTA.37560107A"><span>Turbulence and <span class="hlt">entrainment</span> length scales in large wind farms</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Andersen, Søren J.; Sørensen, Jens N.; Mikkelsen, Robert F.</p> <p>2017-03-01</p> <p>A number of large wind farms are modelled using large eddy simulations to elucidate the <span class="hlt">entrainment</span> process. A reference simulation without turbines and three farm simulations with different degrees of imposed atmospheric turbulence are presented. The <span class="hlt">entrainment</span> process is assessed using proper orthogonal decomposition, which is employed to detect the largest and most energetic coherent turbulent structures. The dominant length scales responsible for the <span class="hlt">entrainment</span> process are shown to grow further into the wind farm, but to be limited in extent by the streamwise turbine spacing, which could be taken into account when developing farm layouts. The self-organized motion or large coherent structures also yield high correlations between the power productions of consecutive turbines, which can be exploited through dynamic farm control. This article is part of the themed issue 'Wind energy in complex terrains'.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28265028','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28265028"><span>Turbulence and <span class="hlt">entrainment</span> length scales in large wind farms.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Andersen, Søren J; Sørensen, Jens N; Mikkelsen, Robert F</p> <p>2017-04-13</p> <p>A number of large wind farms are modelled using large eddy simulations to elucidate the <span class="hlt">entrainment</span> process. A reference simulation without turbines and three farm simulations with different degrees of imposed atmospheric turbulence are presented. The <span class="hlt">entrainment</span> process is assessed using proper orthogonal decomposition, which is employed to detect the largest and most energetic coherent turbulent structures. The dominant length scales responsible for the <span class="hlt">entrainment</span> process are shown to grow further into the wind farm, but to be limited in extent by the streamwise turbine spacing, which could be taken into account when developing farm layouts. The self-organized motion or large coherent structures also yield high correlations between the power productions of consecutive turbines, which can be exploited through dynamic farm control.This article is part of the themed issue 'Wind energy in complex terrains'.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21753000','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21753000"><span>Tagging the neuronal <span class="hlt">entrainment</span> to beat and meter.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nozaradan, Sylvie; Peretz, Isabelle; Missal, Marcus; Mouraux, André</p> <p>2011-07-13</p> <p>Feeling the beat and meter is fundamental to the experience of music. However, how these periodicities are represented in the brain remains largely unknown. Here, we test whether this function emerges from the <span class="hlt">entrainment</span> of neurons resonating to the beat and meter. We recorded the electroencephalogram while participants listened to a musical beat and imagined a binary or a ternary meter on this beat (i.e., a march or a waltz). We found that the beat elicits a sustained periodic EEG response tuned to the beat frequency. Most importantly, we found that meter imagery elicits an additional frequency tuned to the corresponding metric interpretation of this beat. These results provide compelling evidence that neural <span class="hlt">entrainment</span> to beat and meter can be captured directly in the electroencephalogram. More generally, our results suggest that music constitutes a unique context to explore <span class="hlt">entrainment</span> phenomena in dynamic cognitive processing at the level of neural networks.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4879263','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4879263"><span>Potent social synchronization can override photic <span class="hlt">entrainment</span> of circadian rhythms</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fuchikawa, Taro; Eban-Rothschild, Ada; Nagari, Moshe; Shemesh, Yair; Bloch, Guy</p> <p>2016-01-01</p> <p>Circadian rhythms in behaviour and physiology are important for animal health and survival. Studies with individually isolated animals in the laboratory have consistently emphasized the dominant role of light for the <span class="hlt">entrainment</span> of circadian rhythms to relevant environmental cycles. Although in nature interactions with conspecifics are functionally significant, social signals are typically not considered important time-givers for the animal circadian clock. Our results challenge this view. By studying honeybees in an ecologically relevant context and using a massive data set, we demonstrate that social <span class="hlt">entrainment</span> can be potent, may act without direct contact with other individuals and does not rely on gating the exposure to light. We show for the first time that social time cues stably <span class="hlt">entrain</span> the clock, even in animals experiencing conflicting photic and social environmental cycles. These findings add to the growing appreciation for the importance of studying circadian rhythms in ecologically relevant contexts. PMID:27210069</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017HMT...tmp..163W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017HMT...tmp..163W"><span>Dryout-type critical heat flux in vertical upward annular flow: effects of <span class="hlt">entrainment</span> rate, initial <span class="hlt">entrained</span> fraction and diameter</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wu, Zan; Wadekar, Vishwas; Wang, Chenglong; Sunden, Bengt</p> <p>2017-07-01</p> <p>This study aims to reveal the effects of liquid <span class="hlt">entrainment</span>, initial <span class="hlt">entrained</span> fraction and tube diameter on liquid film dryout in vertical upward annular flow for flow boiling. <span class="hlt">Entrainment</span> and deposition rates of droplets were included in mass conservation equations to estimate the local liquid film mass flux in annular flow, and the critical vapor quality at dryout conditions. Different <span class="hlt">entrainment</span> rate correlations were evaluated using flow boiling data of water and organic liquids including n-pentane, iso-octane and R134a. Effect of the initial <span class="hlt">entrained</span> fraction (IEF) at the churn-to-annular flow transition was also investigated. A transitional Boiling number was proposed to separate the IEF-sensitive region at high Boiling numbers and the IEF-insensitive region at low Boiling numbers. Besides, the diameter effect on dryout vapor quality was studied. The dryout vapor quality increases with decreasing tube diameter. It needs to be pointed out that the dryout characteristics of submillimeter channels might be different because of different mechanisms of dryout, i.e., drying of liquid film underneath long vapor slugs and flow boiling instabilities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004APS..DFD.KP007B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004APS..DFD.KP007B"><span>Fluctuations of a receding contact line near the <span class="hlt">entrainment</span> transition</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bico, Jose; Delon, Giles; Fermigier, Marc</p> <p>2004-11-01</p> <p>We study experimentally the fluctuations of a contact line receding on a plane solid substrate. The contact line is perturbed by localized defects and we follow the relaxation of perturbations induced by these defects, as a function of the mean contact line speed and wavelengths characteristic of the perturbations. We compare our results with theoretical predictions by Golestanian and Raphael showing a divergence of the relaxation time at the <span class="hlt">entrainment</span> transition (when the receding velocity exceeds a critical value, the liquid is <span class="hlt">entrained</span> by the solid).</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AGUFM.T41C1322L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AGUFM.T41C1322L"><span>Evidence for Little Shallow <span class="hlt">Entrainment</span> in Starting Mantle Plumes</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lohmann, F. C.; Phipps Morgan, J.; Hort, M.</p> <p>2005-12-01</p> <p>Basalts from intraplate or hotspot ocean islands show distinct geochemical signatures. Their diversity in composition is generally believed to result from the upwelling plume <span class="hlt">entraining</span> shallow mantle material during ascent, while potentially also <span class="hlt">entraining</span> other deep regions of the mantle. Here we present results from analogue laboratory experiments and numerical modelling that there is evidence for little shallow <span class="hlt">entrainment</span> into ascending mantle plumes, i.e. most of the plume signature is inherited from the source. We conducted laboratory experiments using glucose syrup contaminated with glass beads to visualize fluid flow and origin. The plume is initiated by heating from below or by injecting hot, uncontaminated syrup. Particle movement is captured by a CCD camera. In our numerical experiments we solve the Stokes equations for a viscous fluid at infinite Prandtl number with passive tracer particles being used to track fluid flow and <span class="hlt">entrainment</span> rates, simulating laboratory as well as mantle conditions. In both analogue experiments and numerical models we observe the classical plume structure being embedded in a `sheath' of material from the plume source region that retains little of the original temperature anomaly of the plume source. Yet, this sheath ascends in the `slipstream' of the plume at speeds close to the ascent speed of the plume head, and effectively prevents the <span class="hlt">entrainment</span> of surrounding material into the plume head or plume tail. We find that the source region is most effectively sampled by an ascending plume and that compositional variations in the source region are preserved during plume ascent. The plume center and plume sheath combined are composed of up to 85% source material. However, there is also evidence of significant <span class="hlt">entrainment</span> of up to 30% of surrounding material into the outer layers of the plume sheath. <span class="hlt">Entrainment</span> rates are found to be influenced by mantle composition and structure, with the radial viscosity profile of the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12617294','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12617294"><span><span class="hlt">Entrainment</span> of radio frequency chaff by wind as a function of surface aerodynamic roughness.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gillies, John A; Nickling, William G</p> <p>2003-02-01</p> <p>Radio frequency (RF) chaff (approximately 2-cm x 25-microm diameter aluminum-coated glass silicate cylinders) released by military aircraft during testing and training activities has the potential to become <span class="hlt">entrained</span> by wind upon settling to the Earth's surface. Once <span class="hlt">entrained</span> from the surface there is the potential for RF chaff to be abraded and produce PM10 and PM2.5, which are regulated pollutants and pose health concerns. A series of portable wind tunnel tests were carried out to examine the propensity of RF chaff to become <span class="hlt">entrained</span> by wind by defining the relationship between the threshold friction velocity of RF chaff (u(*t RF chaff)) and aerodynamic roughness (z(o)) of surfaces onto which it may deposit. The test surfaces were of varying roughness including types near the Naval <span class="hlt">Air</span> Station (NAS), Fallon, NV, where RF chaff is released. The u(*t) of this fibrous material ranged from 0.14 m/sec for a smooth playa to 0.82 m/sec for a rough crusted playa surface with larger cobble-sized (approximately 6-26-cm diameter) rocks rising above the surface. The u(*t RF chaff) is dependent on the z(o) of the surface onto which it falls as well as the physical characteristics of the roughness. The wind regime of Fallon would allow for chaff suspension events to occur should it settle on typical surfaces in the area. However, the wind climatology of this area makes the probability of such events relatively low.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2006AtmEn..40.2409Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2006AtmEn..40.2409Y"><span>Enhanced water vapor in Asian dust layer: <span class="hlt">Entrainment</span> processes and implication for aerosol optical properties</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yoon, Soon-Chang; Kim, Sang-Woo; Kim, Jiyoung; Sohn, Byung-Ju; Jefferson, Anne; Choi, Suk-Jin; Cha, Dong-Hyun; Lee, Dong-Kyou; Anderson, Theodore L.; Doherty, Sarah J.; Weber, Rodney J.</p> <p></p> <p>The <span class="hlt">entrainment</span> process of water vapor into the dust layer during Asian dust events and the effect of water vapor associated with the Asian dust layer (ADL) on aerosol hygroscopic properties are investigated. The <span class="hlt">entrainment</span> processes of water vapor into the ADL is examined by using a PSU/NCAR MM5 together with the backward trajectory model, radiosonde data, and remotely sensed aerosol vertical distribution data. Two dust events in the spring of 1998 and 2001 are examined in detail. The results reveal that the water vapor mixing ratio (WVMR) derived by the MM5 fits in well with the WVMR observed by radiosonde, and is well coincident with the aerosol extinction coefficient ( σep) measured by the micro-pulse lidar. The temporal evolution of the vertical distributions of WVMR and σep exhibited similar features. On the basis of a well simulation of the enhanced water vapor within the dust layer by the MM5, we trace the dust storms to examine the <span class="hlt">entrainment</span> mechanism. The enhancement of WVMR within the ADL was initiated over the mountainous areas. The relatively moist <span class="hlt">air</span> mass in the well-developed mixing layer over the mountainous areas is advected upward from the boundary layer by an ascending motion. However, a large portion of the water vapor within the ADL is enhanced over the edge of a highland and the plains in China. This is well supported by the simulated WVMR and the wind vectors. Aircraft-based in situ measurements of the chemical and optical properties of aerosol enable a quantitative estimation of the effect of the enhanced WVMR on the aerosol hygroscopic properties. The submicron aerosol accompanied by the dust storm caused an increase of aerosol scattering through water uptakes during the transport. This increase could be explained by the chemical fact that water-soluble submicron pollution aerosols are enriched in the ADL.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ACP....1615433T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ACP....1615433T"><span>Observing <span class="hlt">entrainment</span> mixing, photochemical ozone production, and regional methane emissions by aircraft using a simple mixed-layer framework</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Trousdell, Justin F.; Conley, Stephen A.; Post, Andy; Faloona, Ian C.</p> <p>2016-12-01</p> <p>In situ flight data from two distinct campaigns during winter and summer seasons in the San Joaquin Valley (SJV) of California are used to calculate boundary-layer <span class="hlt">entrainment</span> rates, ozone photochemical production rates, and regional methane emissions. Flights near Fresno, California, in January and February 2013 were conducted in concert with the NASA DISCOVER-AQ project. The second campaign (ArvinO3), consisting of 11 days of flights spanning June through September 2013 and 2014, focused on the southern end of the SJV between Bakersfield and the small town of Arvin, California - a region notorious for frequent violations of ozone <span class="hlt">air</span> quality standards. <span class="hlt">Entrainment</span> velocities, the parameterized rates at which free tropospheric <span class="hlt">air</span> is incorporated into the atmospheric boundary layer (ABL), are estimated from a detailed budget of the inversion base height. During the winter campaign near Fresno, we find an average midday <span class="hlt">entrainment</span> velocity of 1.5 cm s-1, and a maximum of 2.4 cm s-1. The <span class="hlt">entrainment</span> velocities derived during the summer months near Bakersfield averaged 3 cm s-1 (ranging from 0.9 to 6.5 cm s-1), consistent with stronger surface heating in the summer months. Using published data on boundary-layer heights we find that <span class="hlt">entrainment</span> rates across the Central Valley of California have a bimodal annual distribution peaking in spring and fall when the lower tropospheric stability (LTS) is changing most rapidly.Applying the <span class="hlt">entrainment</span> velocities to a simple mixed-layer model of three other scalars (O3, CH4, and H2O), we solve for ozone photochemical production rates and find wintertime ozone production (2.8 ± 0.7 ppb h-1) to be about one-third as large as in the summer months (8.2 ± 3.1 ppb h-1). Moreover, the summertime ozone production rates observed above Bakersfield-Arvin exhibit an inverse relationship to a proxy for the volatile organic compound (VOC) : NOx ratio (aircraft [CH4] divided by surface [NO2]), consistent with a NOx-limited photochemical</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4973929','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4973929"><span>A Genome-Wide Search for Greek and Jewish <span class="hlt">Admixture</span> in the Kashmiri Population</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tashi, Tsewang; Lorenzo, Felipe Ramos; Feusier, Julie Ellen; Mir, Hyder</p> <p>2016-01-01</p> <p>The Kashmiri population is an ethno-linguistic group that resides in the Kashmir Valley in northern India. A longstanding hypothesis is that this population derives ancestry from Jewish and/or Greek sources. There is historical and archaeological evidence of ancient Greek presence in India and Kashmir. Further, some historical accounts suggest ancient Hebrew ancestry as well. To date, it has not been determined whether signatures of Greek or Jewish <span class="hlt">admixture</span> can be detected in the Kashmiri population. Using genome-wide genotyping and <span class="hlt">admixture</span> detection methods, we determined there are no significant or substantial signs of Greek or Jewish <span class="hlt">admixture</span> in modern-day Kashmiris. The ancestry of Kashmiri Tibetans was also determined, which showed signs of <span class="hlt">admixture</span> with populations from northern India and west Eurasia. These results contribute to our understanding of the existing population structure in northern India and its surrounding geographical areas. PMID:27490348</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27490348','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27490348"><span>A Genome-Wide Search for Greek and Jewish <span class="hlt">Admixture</span> in the Kashmiri Population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Downie, Jonathan M; Tashi, Tsewang; Lorenzo, Felipe Ramos; Feusier, Julie Ellen; Mir, Hyder; Prchal, Josef T; Jorde, Lynn B; Koul, Parvaiz A</p> <p>2016-01-01</p> <p>The Kashmiri population is an ethno-linguistic group that resides in the Kashmir Valley in northern India. A longstanding hypothesis is that this population derives ancestry from Jewish and/or Greek sources. There is historical and archaeological evidence of ancient Greek presence in India and Kashmir. Further, some historical accounts suggest ancient Hebrew ancestry as well. To date, it has not been determined whether signatures of Greek or Jewish <span class="hlt">admixture</span> can be detected in the Kashmiri population. Using genome-wide genotyping and <span class="hlt">admixture</span> detection methods, we determined there are no significant or substantial signs of Greek or Jewish <span class="hlt">admixture</span> in modern-day Kashmiris. The ancestry of Kashmiri Tibetans was also determined, which showed signs of <span class="hlt">admixture</span> with populations from northern India and west Eurasia. These results contribute to our understanding of the existing population structure in northern India and its surrounding geographical areas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/471454','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/471454"><span><span class="hlt">Admixture</span> enhanced controlled low-strength material for direct underwater injection with minimal cross-contamination</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Hepworth, H.K.; Davidson, J.S.; Hooyman, J.L.</p> <p>1997-03-01</p> <p>Commercially available <span class="hlt">admixtures</span> have been developed for placing traditional concrete products under water. This paper evaluates adapting anti-washout <span class="hlt">admixture</span> (AWA) and high range water reducing <span class="hlt">admixture</span> (HRWRA) products to enhance controlled low-strength materials (CLSMs) for underwater placement. A simple experimental scale model (based on dynamic and geometric similitude) of typical grout pump emplacement equipment has been developed to determine the percentage of cementing material washed out. The objective of this study was to identify proportions of <span class="hlt">admixtures</span> and underwater CLSM emplacement procedures which would minimize the cross-contamination of the displaced water while maintaining the advantages of CLSM. Since the displaced water from radioactively contaminated systems must be subsequently treated prior to release to the environment, the amount of cross-contamination is important for cases in which cementing material could form hard sludges in a water treatment facility and contaminate the in-place CLSM stabilization medium.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1990JEP....58..387P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1990JEP....58..387P"><span>Influence of nonisothermicity of the medium and polymer <span class="hlt">admixtures</span> on a turbulent vertical wall jet</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pokryvailo, N. A.; Shashmin, V. K.; Shul'Man, Z. P.</p> <p>1990-04-01</p> <p>The results are given on an experimental investigation of the effect of small polymer <span class="hlt">admixtures</span> and density inhomogeneity of the ambient medium on the laws of development of plane, vertical, turbulent wall jets.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17252253','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17252253"><span>Adding value to cocoa (Theobroma cacao L.) germplasm information with domestication history and <span class="hlt">admixture</span> mapping.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marcano, Maria; Pugh, Tatiana; Cros, Emile; Morales, Sonia; Portillo Páez, Elvis A; Courtois, Brigitte; Glaszmann, Jean Christophe; Engels, Jan M M; Phillips, Wilbert; Astorga, Carlos; Risterucci, Ange Marie; Fouet, Olivier; González, Ventura; Rosenberg, Kai; Vallat, Isabelle; Dagert, Manuel; Lanaud, Claire</p> <p>2007-03-01</p> <p>A sound understanding of crop history can provide the basis for deriving novel genetic information through <span class="hlt">admixture</span> mapping. We confirmed this, by using characterization data from an international collection of cocoa, collected 25 years ago, and from a contemporary plantation. We focus on the trees derived from three centuries of <span class="hlt">admixture</span> between Meso-American Criollo and South American Forastero genomes. In both cacao sets of individuals, linkage disequilibrium extended over long genetic distances along chromosome regions, as expected in populations derived from recent <span class="hlt">admixture</span>. Based on loose genome scans, genomic regions involved in useful traits were identified. Fifteen genomic regions involved in seed and fruit weight variation were highlighted. They correspond to ten previously identified QTLs and five novel ones. <span class="hlt">Admixture</span> mapping can help to add value to genetic resources and thus, help to encourage investment in their conservation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA031002','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA031002"><span>Evaluation of <span class="hlt">Admixtures</span> for Use in Concrete to be Placed Underwater.</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1976-09-01</p> <p>tremie method. The tremie used consisted of a pipe topped with a receiving funnel and plugged at the discharge end to keep the pipe sealed until filled ...to determine if these commercially available <span class="hlt">admixtures</span> when used in concrete to be placed underwater increase the flowability of the concrete. Test...results indicated that the use of either a retarding <span class="hlt">admixture</span> or a plasticizer did not increase the flowability of equal-slump concrete, regardless of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/20026624','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/20026624"><span>The influence of compound <span class="hlt">admixtures</span> on the properties of high-content slag cement</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dongxu, L.; Xuequan, W.; Jinlin, S.; Yujiang, W.</p> <p>2000-01-01</p> <p>Based on the activation theory of alkali and sulfate, the influence of compound <span class="hlt">admixtures</span> on the properties of high-content slag cement was studied by testing the strength, pore structure, hydrates, and microstructure, Test results show that compound <span class="hlt">admixtures</span> can obviously improve the properties of high-content slag cement. The emphasis of the present research is two-fold: substituting gypsum with anhydrite and calcining gypsum. These both can improve early and later performance.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25078957','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25078957"><span>Ancestry informative markers clarify the regional <span class="hlt">admixture</span> variation in the Costa Rican population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cámpos-Sanchez, Rebeca; Raventós, Henriette; Barrantes, Ramiro</p> <p>2013-10-01</p> <p>The genetic structure of Costa Rica's population is complex, both by region and by individual, due to the <span class="hlt">admixture</span> process that started during the 15th century and historical events thereafter. Previous studies have been done mostly on Amerindian populations and the Central Valley inhabitants using various microsatellites and mitochondrial DNA markers. Here, we study for the first time a random sample from all regions of the country with ancestry informative markers (AIMs) to address the individual and regional <span class="hlt">admixture</span> proportions. A sample of 160 male individuals was screened for 78 AIMs customized in a GoldenGate platform from Illumina. We observed that this small set of AIMs has the same power of hundreds of microsatellites and thousands of single-nucleotide polymorphisms to evaluate <span class="hlt">admixture</span>, with the benefit of reducing genotyping costs. This type of investigation is necessary to explore new genetic markers useful for forensic and genetic investigation. Our data showed a mean <span class="hlt">admixture</span> proportion of 49.2% European (EUR), 37.8% Native American (NAM), and 12.9% African (AFR), with a disproportionate <span class="hlt">admixture</span> composition by region. In addition, when Chinese (CHB) was included as a fourth component, the proportions changed to 45.6% EUR, 33.5% NAM, 11.7% AFR, and 9.2% CHB. The <span class="hlt">admixture</span> trend is consistent among all regions (EUR > NAM > AFR), and individual <span class="hlt">admixture</span> estimates vary broadly in each region. Though we did not find stratification in Costa Rica's population, gene <span class="hlt">admixture</span> should be evaluated in future genetic studies of Costa Rica, especially for the Caribbean region, as it contains the largest proportion of African ancestry (30.9%).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRD..122.6075K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRD..122.6075K"><span>The effect of <span class="hlt">entrainment</span> through atmospheric boundary layer growth on observed and modeled surface ozone in the Colorado Front Range</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kaser, L.; Patton, E. G.; Pfister, G. G.; Weinheimer, A. J.; Montzka, D. D.; Flocke, F.; Thompson, A. M.; Stauffer, R. M.; Halliday, H. S.</p> <p>2017-06-01</p> <p>Ozone concentrations at the Earth's surface are controlled by meteorological and chemical processes and are a function of advection, <span class="hlt">entrainment</span>, deposition, and net chemical production/loss. The relative contributions of these processes vary in time and space. Understanding the relative importance of these processes controlling surface ozone concentrations is an essential component for designing effective regulatory strategies. Here we focus on the diurnal cycle of <span class="hlt">entrainment</span> through atmospheric boundary layer (ABL) growth in the Colorado Front Range. Aircraft soundings and surface observations collected in July/August 2014 during the DISCOVER-AQ/FRAPPÉ (Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to <span class="hlt">Air</span> Quality/Front Range <span class="hlt">Air</span> Pollution and Photochemistry Éxperiment) campaigns and equivalent data simulated by a regional chemical transport model are analyzed. <span class="hlt">Entrainment</span> through ABL growth is most important in the early morning, fumigating the surface at a rate of 5 ppbv/h. The fumigation effect weakens near noon and changes sign to become a small dilution effect in the afternoon on the order of -1 ppbv/h. The chemical transport model WRF-Chem (Weather Research and Forecasting Model with chemistry) underestimates ozone at all altitudes during this study on the order of 10-15 ppbv. The <span class="hlt">entrainment</span> through ABL growth is overestimated by the model in the order of 0.6-0.8 ppbv/h. This results from differences in boundary layer growth in the morning and ozone concentration jump across the ABL top in the afternoon. This implicates stronger modeled fumigation in the morning and weaker modeled dilution after 11:00 LT.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24026093','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24026093"><span>Estimating individual <span class="hlt">admixture</span> proportions from next generation sequencing data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Skotte, Line; Korneliussen, Thorfinn Sand; Albrechtsen, Anders</p> <p>2013-11-01</p> <p>Inference of population structure and individual ancestry is important both for population genetics and for association studies. With next generation sequencing technologies it is possible to obtain genetic data for all accessible genetic variations in the genome. Existing methods for <span class="hlt">admixture</span> analysis rely on known genotypes. However, individual genotypes cannot be inferred from low-depth sequencing data without introducing errors. This article presents a new method for inferring an individual's ancestry that takes the uncertainty introduced in next generation sequencing data into account. This is achieved by working directly with genotype likelihoods that contain all relevant information of the unobserved genotypes. Using simulations as well as publicly available sequencing data, we demonstrate that the presented method has great accuracy even for very low-depth data. At the same time, we demonstrate that applying existing methods to genotypes called from the same data can introduce severe biases. The presented method is implemented in the NGSadmix software available at http://www.popgen.dk/software.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27324836','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27324836"><span><span class="hlt">Admixture</span> into and within sub-Saharan Africa.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Busby, George Bj; Band, Gavin; Si Le, Quang; Jallow, Muminatou; Bougama, Edith; Mangano, Valentina D; Amenga-Etego, Lucas N; Enimil, Anthony; Apinjoh, Tobias; Ndila, Carolyne M; Manjurano, Alphaxard; Nyirongo, Vysaul; Doumba, Ogobara; Rockett, Kirk A; Kwiatkowski, Dominic P; Spencer, Chris Ca</p> <p>2016-06-21</p> <p>Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to <span class="hlt">admixture</span>. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15497296','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15497296"><span>Effects of a midazolam-ketamine <span class="hlt">admixture</span> in human volunteers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Morse, Zac; Sano, Kimito; Kanri, Tomio</p> <p>2004-01-01</p> <p>As the ideal sedative does not exist for all situations, we examined the effect of a midazolam-ketamine sedoanalgesic <span class="hlt">admixture</span> in human volunteers. Ten ASA physical status I volunteers were administered loading doses of 0.07 mg/kg of midazolam followed by 0.7 mg/kg of ketamine. The same amount of midazolam and ketamine was then infused constantly over 1 hour via a 60 drops (gtts)/mL i.v. infusion set. Blood samples were analyzed for plasma catecholamine levels. Respiration rate and oxygen saturation did not alter significantly from baseline levels. Heart rate and systolic blood pressure remained stable with an increase of 15% in heart rate and 6% in systolic blood pressure only at 10 minutes following the bolus loading. Diastolic blood pressure did not alter significantly from baseline levels (P < .05). Plasma catecholamines levels remained stable except for an increase in epinephrine (38%) and norepinephrine (19%) 10 minutes following the bolus injections. Plasma dopamine levels remained unchanged. There were no cases of unpleasant dreaming, dysphoria, or emergence-type reactions. This combined nonnarcotic sedoanalgesic technique maintains spontaneous ventilation and stable cardiorespiratory parameters and may be considered as an alternative to traditional conscious sedation or general anesthesia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26863142','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26863142"><span>Strong Selection at MHC in Mexicans since <span class="hlt">Admixture</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhou, Quan; Zhao, Liang; Guan, Yongtao</p> <p>2016-02-01</p> <p>Mexicans are a recent <span class="hlt">admixture</span> of Amerindians, Europeans, and Africans. We performed local ancestry analysis of Mexican samples from two genome-wide association studies obtained from dbGaP, and discovered that at the MHC region Mexicans have excessive African ancestral alleles compared to the rest of the genome, which is the hallmark of recent selection for admixed samples. The estimated selection coefficients are 0.05 and 0.07 for two datasets, which put our finding among the strongest known selections observed in humans, namely, lactase selection in northern Europeans and sickle-cell trait in Africans. Using inaccurate Amerindian training samples was a major concern for the credibility of previously reported selection signals in Latinos. Taking advantage of the flexibility of our statistical model, we devised a model fitting technique that can learn Amerindian ancestral haplotype from the admixed samples, which allows us to infer local ancestries for Mexicans using only European and African training samples. The strong selection signal at the MHC remains without Amerindian training samples. Finally, we note that medical history studies suggest such a strong selection at MHC is plausible in Mexicans.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26199374','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26199374"><span>Chloroplast heterogeneity and historical <span class="hlt">admixture</span> within the genus Malus.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Volk, Gayle M; Henk, Adam D; Baldo, Angela; Fazio, Gennaro; Chao, C Thomas; Richards, Christopher M</p> <p>2015-07-01</p> <p>• The genus Malus represents a unique and complex evolutionary context in which to study domestication. Several Malus species have provided novel alleles and traits to the cultivars. The extent of <span class="hlt">admixture</span> among wild Malus species has not been well described, due in part to limited sampling of individuals within a taxon.• Four chloroplast regions (1681 bp total) were sequenced and aligned for 412 Malus individuals from 30 species. Phylogenetic relationships were reconstructed using maximum parsimony. The distribution of chloroplast haplotypes among species was examined using statistical parsimony, phylogenetic trees, and a median-joining network.• Chloroplast haplotypes are shared among species within Malus. Three major haplotype-sharing networks were identified. One includes species native to China, Western North America, as well as Malus domestica Borkh, and its four primary progenitor species: M. sieversii (Ledeb.) M. Roem., M. orientalis Uglitzk., M. sylvestris (L.) Mill., and M. prunifolia (Willd.) Borkh; another includes five Chinese Malus species, and a third includes the three Malus species native to Eastern North America.• Chloroplast haplotypes found in M. domestica belong to a single, highly admixed network. Haplotypes shared between the domesticated apple and its progenitors may reflect historical introgression or the retention of ancestral polymorphisms. Multiple individuals should be sampled within Malus species to reveal haplotype heterogeneity, if complex maternal contributions to named species are to be recognized. © 2015 Botanical Society of America, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2007487','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2007487"><span>Effects of a midazolam-ketamine <span class="hlt">admixture</span> in human volunteers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Morse, Zac; Sano, Kimito; Kanri, Tomio</p> <p>2004-01-01</p> <p>As the ideal sedative does not exist for all situations, we examined the effect of a midazolam-ketamine sedoanalgesic <span class="hlt">admixture</span> in human volunteers. Ten ASA physical status I volunteers were administered loading doses of 0.07 mg/kg of midazolam followed by 0.7 mg/kg of ketamine. The same amount of midazolam and ketamine was then infused constantly over 1 hour via a 60 drops (gtts)/mL i.v. infusion set. Blood samples were analyzed for plasma catecholamine levels. Respiration rate and oxygen saturation did not alter significantly from baseline levels. Heart rate and systolic blood pressure remained stable with an increase of 15% in heart rate and 6% in systolic blood pressure only at 10 minutes following the bolus loading. Diastolic blood pressure did not alter significantly from baseline levels (P < .05). Plasma catecholamines levels remained stable except for an increase in epinephrine (38%) and norepinephrine (19%) 10 minutes following the bolus injections. Plasma dopamine levels remained unchanged. There were no cases of unpleasant dreaming, dysphoria, or emergence-type reactions. This combined nonnarcotic sedoanalgesic technique maintains spontaneous ventilation and stable cardiorespiratory parameters and may be considered as an alternative to traditional conscious sedation or general anesthesia. PMID:15497296</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4915815','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4915815"><span><span class="hlt">Admixture</span> into and within sub-Saharan Africa</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Busby, George BJ; Band, Gavin; Si Le, Quang; Jallow, Muminatou; Bougama, Edith; Mangano, Valentina D; Amenga-Etego, Lucas N; Enimil, Anthony; Apinjoh, Tobias; Ndila, Carolyne M; Manjurano, Alphaxard; Nyirongo, Vysaul; Doumba, Ogobara; Rockett, Kirk A; Kwiatkowski, Dominic P; Spencer, Chris CA</p> <p>2016-01-01</p> <p>Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to <span class="hlt">admixture</span>. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. DOI: http://dx.doi.org/10.7554/eLife.15266.001 PMID:27324836</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4749250','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4749250"><span>Strong Selection at MHC in Mexicans since <span class="hlt">Admixture</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhou, Quan; Zhao, Liang; Guan, Yongtao</p> <p>2016-01-01</p> <p>Mexicans are a recent <span class="hlt">admixture</span> of Amerindians, Europeans, and Africans. We performed local ancestry analysis of Mexican samples from two genome-wide association studies obtained from dbGaP, and discovered that at the MHC region Mexicans have excessive African ancestral alleles compared to the rest of the genome, which is the hallmark of recent selection for admixed samples. The estimated selection coefficients are 0.05 and 0.07 for two datasets, which put our finding among the strongest known selections observed in humans, namely, lactase selection in northern Europeans and sickle-cell trait in Africans. Using inaccurate Amerindian training samples was a major concern for the credibility of previously reported selection signals in Latinos. Taking advantage of the flexibility of our statistical model, we devised a model fitting technique that can learn Amerindian ancestral haplotype from the admixed samples, which allows us to infer local ancestries for Mexicans using only European and African training samples. The strong selection signal at the MHC remains without Amerindian training samples. Finally, we note that medical history studies suggest such a strong selection at MHC is plausible in Mexicans. PMID:26863142</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26087074','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26087074"><span>Effect of mineral viscosity-enhancing <span class="hlt">admixtures</span> on the solidification of evaporator concentrates.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lin, Chung-Yung; Huang, Wan-Ting</p> <p>2015-11-15</p> <p>It is known that partial replacement of cement by viscosity-enhancing <span class="hlt">admixtures</span>, also known as anti-washout <span class="hlt">admixtures</span>, affects the quality of the waste form or concrete. To reduce the bleeding rate of the paste, the characteristics of various mineral viscosity-enhancing <span class="hlt">admixtures</span> dispersed in saline solutions were investigated, including sedimentation and viscosity. The <span class="hlt">admixture</span> candidates included fly ash, silica fume, bentonite, and palygorskite. The effect of these <span class="hlt">admixtures</span> blended with a cement-based matrix on the bleeding rate of the solidification of evaporator concentrates was also examined in this paper. The experimental results show the palygorskite Type 400 is the best choice to improve the quality of waste form, due to its excellent suspension property in the saline solution. The bleeding rate of paste decreased as the dispersion volume of the <span class="hlt">admixture</span> suspension increased. For consideration of the quality of waste forms and the concentrate loading, the optimization of the palygorskite/concentrate ratio of 15-17 wt% and solidification agent/concentrate ratio of 1.0-1.2 were adopted. With this recipe, the quality of waste forms resulting from the solidification of simulated and actual evaporator concentrates mainly containing chloride met the regulations' requirements.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22150947','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22150947"><span>Chemical stability of <span class="hlt">admixtures</span> combining ziconotide with baclofen during simulated intrathecal administration.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shields, David; Montenegro, Rick; Aclan, Jennifer</p> <p>2007-10-01</p> <p>Objective.  To determine the stability of <span class="hlt">admixtures</span> combining ziconotide with commercially formulated or powdered baclofen during simulated intrathecal infusion under laboratory conditions at 37°. Materials and Methods.  <span class="hlt">Admixtures</span> of ziconotide (25 µg/mL) with commercially formulated (1.5 mg/mL) or powdered (2.0 mg/mL) baclofen were stored in implantable intrathecal pumps at 37°. Drug concentrations were determined with high-performance liquid chromatography, and the length of time that the concentrations of both drugs remained ≥90% and ≥80% of initial (ie, the 90% and 80% stability, respectively) was estimated based on lower 95% confidence bounds obtained via linear regression. Results.  Baclofen was stable in both <span class="hlt">admixtures</span>. In the commercially formulated baclofen <span class="hlt">admixture</span>, the mean ziconotide concentration declined to 82.2% of initial in 30 days; the estimates for 90% and 80% stability were 12 and 29 days, respectively. In the powdered baclofen <span class="hlt">admixture</span>, the mean ziconotide concentration declined to 87.4% of initial in 30 days; the estimates for 90% and 80% stability were 20 and 41 days, respectively. Conclusion.  Ziconotide-baclofen <span class="hlt">admixtures</span> were more stable when prepared using powdered baclofen rather than a commercial baclofen formulation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3330690','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3330690"><span>Population divergence with or without <span class="hlt">admixture</span>: selecting models using an ABC approach</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sousa, V C; Beaumont, M A; Fernandes, P; Coelho, M M; Chikhi, L</p> <p>2012-01-01</p> <p>Genetic data have been widely used to reconstruct the demographic history of populations, including the estimation of migration rates, divergence times and relative <span class="hlt">admixture</span> contribution from different populations. Recently, increasing interest has been given to the ability of genetic data to distinguish alternative models. One of the issues that has plagued this kind of inference is that ancestral shared polymorphism is often difficult to separate from <span class="hlt">admixture</span> or gene flow. Here, we applied an approximate Bayesian computation (ABC) approach to select the model that best fits microsatellite data among alternative splitting and <span class="hlt">admixture</span> models. We performed a simulation study and showed that with reasonably large data sets (20 loci) it is possible to identify with a high level of accuracy the model that generated the data. This suggests that it is possible to distinguish genetic patterns due to past <span class="hlt">admixture</span> events from those due to shared polymorphism (population split without <span class="hlt">admixture</span>). We then apply this approach to microsatellite data from an endangered and endemic Iberian freshwater fish species, in which a clustering analysis suggested that one of the populations could be admixed. In contrast, our results suggest that the observed genetic patterns are better explained by a population split model without <span class="hlt">admixture</span>. PMID:22146980</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2941333','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2941333"><span>Signatures of founder effects, <span class="hlt">admixture</span>, and selection in the Ashkenazi Jewish population</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bray, Steven M.; Mulle, Jennifer G.; Dodd, Anne F.; Pulver, Ann E.; Wooding, Stephen; Warren, Stephen T.</p> <p>2010-01-01</p> <p>The Ashkenazi Jewish (AJ) population has long been viewed as a genetic isolate, yet it is still unclear how population bottlenecks, <span class="hlt">admixture</span>, or positive selection contribute to its genetic structure. Here we analyzed a large AJ cohort and found higher linkage disequilibrium (LD) and identity-by-descent relative to Europeans, as expected for an isolate. However, paradoxically we also found higher genetic diversity, a sign of an older or more admixed population but not of a long-term isolate. Recent reports have reaffirmed that the AJ population has a common Middle Eastern origin with other Jewish Diaspora populations, but also suggest that the AJ population, compared with other Jews, has had the most European <span class="hlt">admixture</span>. Our analysis indeed revealed higher European <span class="hlt">admixture</span> than predicted from previous Y-chromosome analyses. Moreover, we also show that <span class="hlt">admixture</span> directly correlates with high LD, suggesting that <span class="hlt">admixture</span> has increased both genetic diversity and LD in the AJ population. Additionally, we applied extended haplotype tests to determine whether positive selection can account for the level of AJ-prevalent diseases. We identified genomic regions under selection that account for lactose and alcohol tolerance, and although we found evidence for positive selection at some AJ-prevalent disease loci, the higher incidence of the majority of these diseases is likely the result of genetic drift following a bottleneck. Thus, the AJ population shows evidence of past founding events; however, <span class="hlt">admixture</span> and selection have also strongly influenced its current genetic makeup. PMID:20798349</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4706412','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4706412"><span>A Novel <span class="hlt">Admixture</span>-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Claudio-Campos, Karla; Rivera-Miranda, Giselle; Bermúdez-Bosch, Luis; Renta, Jessicca Y.; Cadilla, Carmen L.; Cruz, Iadelisse; Feliu, Juan F.; Vergara, Cunegundo; Ruaño, Gualberto</p> <p>2016-01-01</p> <p>Aim This study is aimed at developing a novel <span class="hlt">admixture</span>-adjusted pharmacogenomic approach to individually refine warfarin dosing in Caribbean Hispanic patients. Patients & Methods A multiple linear regression analysis of effective warfarin doses versus relevant genotypes, <span class="hlt">admixture</span>, clinical and demographic factors was performed in 255 patients and further validated externally in another cohort of 55 individuals. Results The <span class="hlt">admixture</span>-adjusted, genotype-guided warfarin dosing refinement algorithm developed in Caribbean Hispanics showed better predictability (R2 = 0.70, MAE = 0.72mg/day) than a clinical algorithm that excluded genotypes and <span class="hlt">admixture</span> (R2 = 0.60, MAE = 0.99mg/day), and outperformed two prior pharmacogenetic algorithms in predicting effective dose in this population. For patients at the highest risk of adverse events, 45.5% of the dose predictions using the developed pharmacogenetic model resulted in ideal dose as compared with only 29% when using the clinical non-genetic algorithm (p<0.001). The <span class="hlt">admixture</span>-driven pharmacogenetic algorithm predicted 58% of warfarin dose variance when externally validated in 55 individuals from an independent validation cohort (MAE = 0.89 mg/day, 24% mean bias). Conclusions Results supported our rationale to incorporate individual’s genotypes and unique <span class="hlt">admixture</span> metrics into pharmacogenetic refinement models in order to increase predictability when expanding them to admixed populations like Caribbean Hispanics. Trial Registration ClinicalTrials.gov NCT01318057 PMID:26745506</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012JIEIA..93...73G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012JIEIA..93...73G"><span>Effect of Waterproofing <span class="hlt">Admixtures</span> on the Flexural Strength and Corrosion Resistance of Concrete</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Geetha, A.; Perumal, P.</p> <p>2012-02-01</p> <p>This paper deals about the flexural strength and corrosion behaviour of concrete using waterproofing <span class="hlt">admixtures</span>. The effect of waterproofing <span class="hlt">admixtures</span> on the corrosion behaviour of RCC specimen has been studied by conducting accelerated corrosion test. To identify the effect of corrosion in pull out strength, corrosion process was induced by means of accelerated corrosion procedure. To accelerate the reinforcement corrosion, direct electric current was impressed on the rebar embedded in the specimen using a DC power supply system that has a facility to adjust voltage. The addition of waterproofing <span class="hlt">admixtures</span> also shows the improvement in the flexural strength of concrete has been studied by conducting flexural strength tests on the concrete prism specimen of size 100 × 100 × 500 mm with and without <span class="hlt">admixtures</span> for various dosages and various curing periods of 7 and 28 days. The results showed that the presence of waterproofing <span class="hlt">admixtures</span> always improves the corrosion resistance and thus increases the strength of concrete due to the hydrophobic action of waterproofing <span class="hlt">admixtures</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25852078','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25852078"><span>Reconstructing Past <span class="hlt">Admixture</span> Processes from Local Genomic Ancestry Using Wavelet Transformation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sanderson, Jean; Sudoyo, Herawati; Karafet, Tatiana M; Hammer, Michael F; Cox, Murray P</p> <p>2015-06-01</p> <p><span class="hlt">Admixture</span> between long-separated populations is a defining feature of the genomes of many species. The mosaic block structure of admixed genomes can provide information about past contact events, including the time and extent of <span class="hlt">admixture</span>. Here, we describe an improved wavelet-based technique that better characterizes ancestry block structure from observed genomic patterns. principal components analysis is first applied to genomic data to identify the primary population structure, followed by wavelet decomposition to develop a new characterization of local ancestry information along the chromosomes. For testing purposes, this method is applied to human genome-wide genotype data from Indonesia, as well as virtual genetic data generated using genome-scale sequential coalescent simulations under a wide range of <span class="hlt">admixture</span> scenarios. Time of <span class="hlt">admixture</span> is inferred using an approximate Bayesian computation framework, providing robust estimates of both <span class="hlt">admixture</span> times and their associated levels of uncertainty. Crucially, we demonstrate that this revised wavelet approach, which we have released as the R package adwave, provides improved statistical power over existing wavelet-based techniques and can be used to address a broad range of <span class="hlt">admixture</span> questions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19840058231&hterms=19+47&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3D19.47','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19840058231&hterms=19+47&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3D19.47"><span>Cumulus clouds - Early aircraft observations and <span class="hlt">entrainment</span> hypotheses</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Simpson, J.</p> <p>1983-01-01</p> <p>The history of cumulus research in the decade following World War II is reviewed in the perspective of the new ideas and advances made during the subsequent generation. Emphasis is placed upon pioneering aircraft measurements, evidence for <span class="hlt">entrainment</span>, the early model attempts and their attendant controversies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2679954','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2679954"><span>Vasoactive intestinal polypeptide <span class="hlt">entrains</span> circadian rhythms in astrocytes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Marpegan, Luciano; Krall, Thomas J.; Herzog, Erik D.</p> <p>2009-01-01</p> <p>Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocytes are highly sensitive to vasoactive intestinal polypeptide (VIP), a neuropeptide released by neurons and important for the coordination of daily cycling, we hypothesized that VIP <span class="hlt">entrains</span> circadian rhythms in astrocytes. We used astrocyte cultures derived from knock-in mice containing a bioluminescent reporter of PERIOD2 (PER2) protein, to assess the effects of VIP on the rhythmic properties of astrocytes. VIP induced a dose-dependent increase in the peak-to-trough amplitude of the ensemble rhythms of PER2 expression with maximal effects near 100nM VIP and threshold values between 0.1 and 1 nM. VIP also induced dose- and phase-dependent shifts in PER2 rhythms and daily VIP administration <span class="hlt">entrained</span> bioluminescence rhythms of astrocytes to a predicted phase angle. This is the first demonstration that a neuropeptide can <span class="hlt">entrain</span> glial cells to a phase predicted by a phase response curve. We conclude that VIP potently <span class="hlt">entrains</span> astrocytes in vitro and is a candidate for coordinating daily rhythms among glia in the brain. PMID:19346450</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016APS..MARB41005M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016APS..MARB41005M"><span>Queueing-Based Synchronization and <span class="hlt">Entrainment</span> for Synthetic Gene Oscillators</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mather, William; Butzin, Nicholas; Hochendoner, Philip; Ogle, Curtis</p> <p></p> <p>Synthetic gene oscillators have been a major focus of synthetic biology research since the beginning of the field 15 years ago. They have proven to be useful both for biotechnological applications as well as a testing ground to significantly develop our understanding of the design principles behind synthetic and native gene oscillators. In particular, the principles governing synchronization and <span class="hlt">entrainment</span> of biological oscillators have been explored using a synthetic biology approach. Our work combines experimental and theoretical approaches to specifically investigate how a bottleneck for protein degradation, which is present in most if not all existing synthetic oscillators, can be leveraged to robustly synchronize and <span class="hlt">entrain</span> biological oscillators. We use both the terminology and mathematical tools of queueing theory to intuitively explain the role of this bottleneck in both synchronization and <span class="hlt">entrainment</span>, which extends prior work demonstrating the usefulness of queueing theory in synthetic and native gene circuits. We conclude with an investigation of how synchronization and <span class="hlt">entrainment</span> may be sensitive to the presence of multiple proteolytic pathways in a cell that couple weakly through crosstalk. This work was supported by NSF Grant #1330180.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19920013089','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19920013089"><span>The neurochemical basis of photic <span class="hlt">entrainment</span> of the circadian pacemaker</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rea, Michael A.; Buckley, Becky; Lutton, Lewis M.</p> <p>1992-01-01</p> <p>Circadian rhythmicity in mammals is controlled by the action of a light-<span class="hlt">entrainable</span> hypothalamus, in association with two cell clusters known as the supra chiasmatic nuclei (SCN). In the absence of temporal environmental clues, this pacemaker continues to measure time by an endogenous mechanism (clock), driving biochemical, physiological, and behavioral rhythms that reflect the natural period of the pacemaker oscillation. This endogenous period usually differs slightly from 24 hours (i.e., circadian). When mammals are maintained under a 24 hour light-dark (LD) cycle, the pacemaker becomes <span class="hlt">entrained</span> such that the period of the pacemaker oscillation matches that of the LD cycle. Potentially <span class="hlt">entraining</span> photic information is conveyed to the SCN via a direct retinal projection, the retinohypothalamic tract (RHT). RHT neurotransmission is thought to be mediated by the release of excitatory amino acids (EAA) in the SCN. In support of this hypothesis, recent experiments using nocturnal rodents have shown that EAA antagonists block the effects of light on pacemaker-driven behavioral rhythms, and attenuate light induced gene expression in SCN cells. An understanding of the neurochemical basis of the photic <span class="hlt">entrainment</span> process would facilitate the development of pharmacological strategies for maintaining synchrony among shift workers in environments, such as the Space Station, which provide unreliable or conflicting temporal photic clues.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=entrainment&id=EJ834320','ERIC'); return false;" href="http://eric.ed.gov/?q=entrainment&id=EJ834320"><span>Lexical <span class="hlt">Entrainment</span> and Lexical Differentiation in Reference Phrase Choice</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Van Der Wege, Mija M.</p> <p>2009-01-01</p> <p>Speakers reuse prior references to objects when choosing reference phrases, a phenomenon known as lexical <span class="hlt">entrainment</span>. One explanation is that speakers want to maintain a set of previously established referential precedents. Speakers may also contrast any new referents against this previously established set, thereby avoiding applying the same…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=64699&keyword=Adsorption+AND+Hg&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=89524602&CFTOKEN=82901706','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=64699&keyword=Adsorption+AND+Hg&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=89524602&CFTOKEN=82901706"><span><span class="hlt">ENTRAINED</span>-FLOW ADSORPTION OF MERCURY USING ACTIVATED CARBON</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Bench-scale experiments were conducted in a flow reactor to simulate <span class="hlt">entrained</span>-flow capture of elemental mercury (Hg) by activated carbon. Adsorption of Hg by several commercial activated carbons was examined at different carbon-to-mercury (C:Hg) ratios (by weight) (600:1 - 29000...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26072361','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26072361"><span>Articulatory constraints on spontaneous <span class="hlt">entrainment</span> between speech and manual gesture.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zelic, Gregory; Kim, Jeesun; Davis, Chris</p> <p>2015-08-01</p> <p>The present study examined the extent to which speech and manual gestures spontaneously <span class="hlt">entrain</span> in a non-communicative task. Participants had to repeatedly utter nonsense /CV/ syllables while continuously moving the right index finger in flexion/extension. No instructions to coordinate were given. We manipulated the type of syllable uttered (/ba/ vs. /sa/), and vocalization (phonated vs. silent speech). Assuming principles of coordination dynamics, a stronger <span class="hlt">entrainment</span> between the fingers oscillations and the jaw motion was predicted (1) for /ba/, due to expected larger amplitude of jaw motion and (2) in phonated speech, due to the auditory feedback. Fifteen out of twenty participants showed simple ratios of speech to finger cycles (1:1, 1:2 or 2:1). In contrast with our predictions, speech-gesture <span class="hlt">entrainment</span> was stronger when vocalizing /sa/ than /ba/, also more widely distributed on an in-phase mode. Furthermore, results revealed a spatial anchoring and an increased temporal variability in jaw motion when producing /sa/. We suggested that this indicates a greater control of the speech articulators for /sa/, making the speech performance more receptive to environmental forces, resulting in the greater <span class="hlt">entrainment</span> observed to gesture oscillations. The speech-gesture coordination was maintained in silent speech, suggesting a somatosensory basis for their endogenous coupling.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016APS..DFDD12005S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016APS..DFDD12005S"><span><span class="hlt">Entrainment</span> at a sediment concentration interface in turbulent channel flow</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Salinas, Jorge; Shringarpure, Mrugesh; Cantero, Mariano; Balachandar, S.</p> <p>2016-11-01</p> <p>In this work we address the role of turbulence on <span class="hlt">entrainment</span> at a sediment concentration interface. This process can be conceived as the <span class="hlt">entrainment</span> of sediment-free fluid into the bottom sediment-laden flow, or alternatively, as the <span class="hlt">entrainment</span> of sediment into the top sediment-free flow. We have performed direct numerical simulations for fixed Reynolds and Schmidt numbers while varying the values of Richardson number and particle settling velocity. The analysis performed shows that the ability of the flow to pick up a given sediment size decreases with the distance from the bottom, and thus only fine enough sediment particles are <span class="hlt">entrained</span> across the sediment concentration interface. For these cases, the concentration profiles evolve to a final steady state in good agreement with the well-known Rouse profile. The approach towards the Rouse profile happens through a transient self-similar state. Detailed analysis of the three dimensional structure of the sediment concentration interface shows the mechanisms by which sediment particles are lifted up by tongues of sediment-laden fluid with positive correlation between vertical velocity and sediment concentration. Finally, the mixing ability of the flow is addressed by monitoring the center of mass of the sediment-laden layer. With the support of ExxonMobil, NSF, ANPCyT, CONICET.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/5971703','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/5971703"><span>Effect of various intake designs on zooplankton <span class="hlt">entrainment</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dycus, D.L.</p> <p>1983-03-01</p> <p>Field studies were conducted at the intakes of three Tennessee Valley Authority electric power plants to determine whether intake design is a feasible means of mitigating effects on zooplankton by minimizing the quantity <span class="hlt">entrained</span>. Three intake designs were evaluated: one with a shallow skimmer wall, one with a deep skimmer wall, and one with no skimmer wall. Many sample sets from these studies were highly variable because of inadequate sample replication, thus precluding the use of statistical tests on some of the data. Where possible, an analysis of variance and a Student, Newman, Keuls multiple range test were computed and tested at the 0.05 level. Several studies indicated possible differences between day and night in the quantity of zooplankton <span class="hlt">entrained</span>. The greater quantities <span class="hlt">entrained</span> at night were related to a greater abundance in the source water body at night rather than to intake design. These results indicate that time-of-day differences might be used to mitigate effects on zooplankton at some intakes if the intake could be operated to require less cooling water when concentrations were greatest. None of these studies indicated that the intake designs studied minimized the quantity of zooplankton <span class="hlt">entrained</span> because the quantities in the intake canals were similar to the quantities in the source water body.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19900005681','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19900005681"><span>Saltation thresholds and <span class="hlt">entrainment</span> of fine particles at Earth and Martian pressures</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Leach, Rodman; Greeley, Ronald; Pollack, James</p> <p>1989-01-01</p> <p>An open circuit wind tunnel designed to operate in a large vacuum chamber was built at NASA-Ames to investigate saltation threshold, flux, deflation rates, and other aeolian phenomena on the planet Mars. The vacuum chamber will operate at pressures as low as 4 mbar, and the tunnel operates at windspeeds as high as 150 m/sec. Either <span class="hlt">air</span> or CO2 can be used as a working fluid. It was found that, to a first order approximation, the same dynamic pressure was required at Martian pressure to <span class="hlt">entrain</span> or saltate particles as was required on Earth, although wind and particle speed are considerably higher at Martian pressure. A 2nd wind tunnel, designed to operate aboard the NASA KC-135 0-g aircraft to obtain information on the effect of gravity on saltation threshold and the interparticle force at 0-g, is also described and test data presented. Some of the experiments are summarized and various aspects of low pressure aeolian <span class="hlt">entrainment</span> for particles 12 to 100 micron in diameter are discussed, some of them unique to low pressure testing and some common in Earth pressure particle transport testing. The facility, the modes of operation, and the materials used are described.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012BoLMe.145...93D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012BoLMe.145...93D"><span>Obtaining Potential Virtual Temperature Profiles, <span class="hlt">Entrainment</span> Fluxes, and Spectra from Mini Unmanned Aerial Vehicle Data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Dias, N. L.; Gonçalves, J. E.; Freire, L. S.; Hasegawa, T.; Malheiros, A. L.</p> <p>2012-10-01</p> <p>We present a simple but effective small unmanned aerial vehicle design that is able to make high-resolution temperature and humidity measurements of the atmospheric boundary layer. The <span class="hlt">air</span> model used is an adapted commercial design, and is able to carry all the instrumentation (barometer, temperature and humidity sensor, and datalogger) required for such measurements. It is fitted with an autopilot that controls the plane's ascent and descent in a spiral to 1800 m above ground. We describe the results obtained on three different days when the plane, called Aerolemma-3, flew continuously throughout the day. Surface measurements of the sensible virtual heat flux made simultaneously allowed the calculation of all standard convective turbulence scales for the boundary layer, as well as a rigorous test of existing models for the <span class="hlt">entrainment</span> flux at the top of the boundary layer, and for its growth. A novel approach to calculate the <span class="hlt">entrainment</span> flux from the top-down, bottom-up model of Wynagaard and Brost is used. We also calculated temperature fluctuations by means of a spectral high-pass filter, and calculated their spectra. Although the time series are small, tapering proved ineffective in this case. The spectra from the untapered series displayed a consistent -5/3 behaviour, and from them it was possible to calculate a dimensionless dissipation function, which exhibited the expected similarity behaviour against boundary-layer bulk stability. The simplicity, ease of use and economy of such small aircraft make us optimistic about their usefulness in boundary-layer research.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFM.A53G0210W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFM.A53G0210W"><span>Observations of Cloud Top <span class="hlt">Entrainment</span> Instability Induced by Aircraft Wake Downwash</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Walcek, C. J.</p> <p>2012-12-01</p> <p>Aircraft produce considerable turbulence and generate 20-80 m/s downward velocity impulses immediately below the airframe and wings. This downward-propagating <span class="hlt">air</span> produces turbulent vortices that descend 100-300 meters before dissipating. If an aircraft flies very close to the tops of stratiform clouds, it can induce mixing between cloudy <span class="hlt">air</span> and clear <span class="hlt">air</span> pushed into the cloud from above cloud top. Here we present photographs and evidence that aircraft flying close to the tops of stable stratiform clouds can trigger the release of cloud-top <span class="hlt">entrainment</span> instability (CTEI). Negatively-buoyant <span class="hlt">air</span> can be produced as warm <span class="hlt">air</span> forced into a cloud from above cloud top mixes with colder cloudy <span class="hlt">air</span>, inducing evaporation and further cooling below the cloud temperature, thus initiating turbulent downdrafts that can propagate the CTEI mechanism that ultimately dissipates and evaporates the top several hundred meters near cloud top. Photographs taken from observation chase planes flying 1-2 km above another aircraft flying very close to cloud top show 50-100 m wide swaths cleared within 3-4 seconds after fly-over, and growth rates of 2-3 m/s lateral to the flight track are observed. Ultimately "canal cloud" or "hole punch" features 2-3 km wide are generated in 20-30 minutes following the flyover from this mechanism. Here the mechanism of aircraft downwash is reviewed, CTEI is described, and evidence of the importance of evaporation and <span class="hlt">entrainment</span> is provided from unpublished results from the late 1940s-era "project CIRRUS" and more recent images of hole-punch and canal-clouds. Since the propagation of this turbulent process occurs in turbulent filaments of mixtures of clear and cloudy <span class="hlt">air</span>, modeling this process will require resolutions of less than several meters, yet require simulation domains several 1000s of meters wide. Similarly, measurements of dissipated cloud regions induced by aircraft would require resolutions of several meters or 10s of Hz to unambiguously</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3842021','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3842021"><span>Neural <span class="hlt">entrainment</span> to rhythmic speech in children with developmental dyslexia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Power, Alan J.; Mead, Natasha; Barnes, Lisa; Goswami, Usha</p> <p>2013-01-01</p> <p>A rhythmic paradigm based on repetition of the syllable “ba” was used to study auditory, visual, and audio-visual oscillatory <span class="hlt">entrainment</span> to speech in children with and without dyslexia using EEG. Children pressed a button whenever they identified a delay in the isochronous stimulus delivery (500 ms; 2 Hz delta band rate). Response power, strength of <span class="hlt">entrainment</span> and preferred phase of <span class="hlt">entrainment</span> in the delta and theta frequency bands were compared between groups. The quality of stimulus representation was also measured using cross-correlation of the stimulus envelope with the neural response. The data showed a significant group difference in the preferred phase of <span class="hlt">entrainment</span> in the delta band in response to the auditory and audio-visual stimulus streams. A different preferred phase has significant implications for the quality of speech information that is encoded neurally, as it implies enhanced neuronal processing (phase alignment) at less informative temporal points in the incoming signal. Consistent with this possibility, the cross-correlogram analysis revealed superior stimulus representation by the control children, who showed a trend for larger peak r-values and significantly later lags in peak r-values compared to participants with dyslexia. Significant relationships between both peak r-values and peak lags were found with behavioral measures of reading. The data indicate that the auditory temporal reference frame for speech processing is atypical in developmental dyslexia, with low frequency (delta) oscillations <span class="hlt">entraining</span> to a different phase of the rhythmic syllabic input. This would affect the quality of encoding of speech, and could underlie the cognitive impairments in phonological representation that are the behavioral hallmark of this developmental disorder across languages. PMID:24376407</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24582903','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24582903"><span><span class="hlt">Entrainment</span> of spontaneous cerebral hemodynamic oscillations to behavioral responses.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pfurtscheller, Gert; Walther, Mario; Bauernfeind, Günther; Barry, Robert J; Witte, Herbert; Müller-Putz, Gernot R</p> <p>2014-04-30</p> <p><span class="hlt">Entrainment</span> in physiological systems can be manifest in cases where phase-coupling (synchronization) between slow intrinsic oscillations and periodic motor responses, or vice versa, takes place. To test whether voluntary movement has something in common with <span class="hlt">entrainment</span> of slow hemodynamic oscillations to motor responses, we studied blood pressure (BP), heart rate beat-to-beat intervals (RRI) and prefrontal (de)oxyhemoglobin (Hb/HbO2) during 5min of rest, 10min of self-paced, voluntary movements and 10min of stimulus-paced movements at 10s intervals in 9 subjects. Subjects were divided into 2 groups according to the timing of voluntary finger movements. It appeared that these movements occurred at relatively regular intervals of approximately 10s in 5 subjects (group A); while 4 subjects showed random or very short inter-movement intervals (group B). Two remarkable results were obtained: first, the phase coupling (COH(2)) between BP and RRI showed a significant (p=0.0061) interaction between activity (rest vs. movement) and group (A vs. B), with an increased (p=0.0003) coupling in group A. Second, the COH(2) between BP and Hb oscillations showed a significant (p=0.034) interaction between activity and group, with a decreased (p=0.079) coupling in group B. These results suggest that subjects able to initiate self-paced, voluntary movements at relatively regular intervals of ∼10s show an <span class="hlt">entrainment</span> potential between physiological oscillations and motor responses. This also provides the first evidence that not only physiological oscillations can be <span class="hlt">entrained</span> to motor responses, but also motor responses (voluntary movements) can be <span class="hlt">entrained</span> to slow intrinsic oscillations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4205645','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4205645"><span><span class="hlt">Entrained</span> neural oscillations in multiple frequency bands comodulate behavior</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Henry, Molly J.; Herrmann, Björn</p> <p>2014-01-01</p> <p>Our sensory environment is teeming with complex rhythmic structure, to which neural oscillations can become synchronized. Neural synchronization to environmental rhythms (<span class="hlt">entrainment</span>) is hypothesized to shape human perception, as rhythmic structure acts to temporally organize cortical excitability. In the current human electroencephalography study, we investigated how behavior is influenced by neural oscillatory dynamics when the rhythmic fluctuations in the sensory environment take on a naturalistic degree of complexity. Listeners detected near-threshold gaps in auditory stimuli that were simultaneously modulated in frequency (frequency modulation, 3.1 Hz) and amplitude (amplitude modulation, 5.075 Hz); modulation rates and types were chosen to mimic the complex rhythmic structure of natural speech. Neural oscillations were <span class="hlt">entrained</span> by both the frequency modulation and amplitude modulation in the stimulation. Critically, listeners’ target-detection accuracy depended on the specific phase–phase relationship between <span class="hlt">entrained</span> neural oscillations in both the 3.1-Hz and 5.075-Hz frequency bands, with the best performance occurring when the respective troughs in both neural oscillations coincided. Neural-phase effects were specific to the frequency bands <span class="hlt">entrained</span> by the rhythmic stimulation. Moreover, the degree of behavioral comodulation by neural phase in both frequency bands exceeded the degree of behavioral modulation by either frequency band alone. Our results elucidate how fluctuating excitability, within and across multiple <span class="hlt">entrained</span> frequency bands, shapes the effective neural processing of environmental stimuli. More generally, the frequency-specific nature of behavioral comodulation effects suggests that environmental rhythms act to reduce the complexity of high-dimensional neural states. PMID:25267634</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25267634','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25267634"><span><span class="hlt">Entrained</span> neural oscillations in multiple frequency bands comodulate behavior.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Henry, Molly J; Herrmann, Björn; Obleser, Jonas</p> <p>2014-10-14</p> <p>Our sensory environment is teeming with complex rhythmic structure, to which neural oscillations can become synchronized. Neural synchronization to environmental rhythms (<span class="hlt">entrainment</span>) is hypothesized to shape human perception, as rhythmic structure acts to temporally organize cortical excitability. In the current human electroencephalography study, we investigated how behavior is influenced by neural oscillatory dynamics when the rhythmic fluctuations in the sensory environment take on a naturalistic degree of complexity. Listeners detected near-threshold gaps in auditory stimuli that were simultaneously modulated in frequency (frequency modulation, 3.1 Hz) and amplitude (amplitude modulation, 5.075 Hz); modulation rates and types were chosen to mimic the complex rhythmic structure of natural speech. Neural oscillations were <span class="hlt">entrained</span> by both the frequency modulation and amplitude modulation in the stimulation. Critically, listeners' target-detection accuracy depended on the specific phase-phase relationship between <span class="hlt">entrained</span> neural oscillations in both the 3.1-Hz and 5.075-Hz frequency bands, with the best performance occurring when the respective troughs in both neural oscillations coincided. Neural-phase effects were specific to the frequency bands <span class="hlt">entrained</span> by the rhythmic stimulation. Moreover, the degree of behavioral comodulation by neural phase in both frequency bands exceeded the degree of behavioral modulation by either frequency band alone. Our results elucidate how fluctuating excitability, within and across multiple <span class="hlt">entrained</span> frequency bands, shapes the effective neural processing of environmental stimuli. More generally, the frequency-specific nature of behavioral comodulation effects suggests that environmental rhythms act to reduce the complexity of high-dimensional neural states.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16187587','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16187587"><span>Three-dimensional modeling of <span class="hlt">air</span> flow and pollutant dispersion in an urban street canyon with thermal effects.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tsai, Mong-Yu; Chen, Kang-Shin; Wu, Chung-Hsing</p> <p>2005-08-01</p> <p>Effects of excess ground and building temperatures on airflow and dispersion of pollutants in an urban street canyon with an aspect ratio of 0.8 and a length-to-width ratio of 3 were investigated numerically. Three-dimensional governing equations of mass, momentum, energy, and species were modeled using the RNG k-epsilon turbulence model and Boussinesq approximation, which were solved using the finite volume method. Vehicle emissions were estimated from the measured traffic flow rates and modeled as banded line sources, with a street length and bandwidths equal to typical vehicle widths. Both measurements and simulations reveal that pollutant concentrations typically follow the traffic flow rate; they decline as the height increases and are higher on the leeward side than on the windward side. Three-dimensional simulations reveal that the vortex line, joining the centers of cross-sectional vortexes of the street canyon, meanders between street buildings and shifts toward the windward side when heating strength is increased. Thermal boundary layers are very thin. <span class="hlt">Entrainment</span> of outside <span class="hlt">air</span> increases, and pollutant concentration decreases with increasing heating condition. Also, traffic-produced turbulence enhances the turbulent kinetic energy and the mixing of temperature and <span class="hlt">admixtures</span> in the canyon. Factors affecting the inaccuracy of the simulations are addressed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/6963208','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/6963208"><span>Method of removing <span class="hlt">entrained</span> particles from flue gas and composition of matter</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Radway, J.E.; Bennett, R.P.</p> <p>1988-04-19</p> <p>A composition of matter to treat particles <span class="hlt">entrained</span> in flue gas, is described comprising: a caustic liquid used to adjust resistivity of the <span class="hlt">entrained</span> particles; and inert particulate matter supporting the caustic liquid for inhibiting chemical action of the caustic liquid until used to adjust the resistivity of the <span class="hlt">entrained</span> particles, the inert particulate matter supporting sufficient caustic liquid to adjust the resistivity of the <span class="hlt">entrained</span> particles.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/949177','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/949177"><span>Estimated <span class="hlt">Entrainment</span> of Dungeness Crab During Dredging For The Columbia River Channel Improvement Project</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Pearson, Walter H.; Williams, Greg D.; Skalski, John R.</p> <p>2002-12-01</p> <p>The studies reported here focus on issues regarding the <span class="hlt">entrainment</span> of Dungeness crab related to the proposed Columbia River Channel Improvement Project and provided direct measurements of crab <span class="hlt">entrainment</span> rates at three locations (Desdomona Shoals, Upper Sands, and Miller Sands) from RM4 to RM24 during summer 2002. <span class="hlt">Entrainment</span> rates for all age classes of crabs ranged from zero at Miller Sands to 0.224 crabs per cy at Desdemona Shoals in June 2002. The overall <span class="hlt">entrainment</span> rate at Desdomona Shoals in September was 0.120 crabs per cy. A modified Dredge Impact Model (DIM) used the summer 2002 <span class="hlt">entrainment</span> rates to project crab <span class="hlt">entrainment</span> and adult equivalent loss and loss to the fishery for the Channel Improvement Project. To improve the projections, <span class="hlt">entrainment</span> data from Flavel Bar is needed. The literature, analyses of salinity intrusion scenarios, and the summer 2002 site-specific data on <span class="hlt">entrainment</span> and salinity all indicate that bottom salinity influences crab distribution and <span class="hlt">entrainment</span>, especially at lower salinities. It is now clear from field measurements of <span class="hlt">entrainment</span> rates and salinity during a period of low river flow (90-150 Kcfs) and high salinity intrusion that <span class="hlt">entrainment</span> rates are zero where bottom salinity is less than 16 o/oo most of the time. Further, <span class="hlt">entrainment</span> rates of 2+ and older crab fall with decreasing salinity in a clear and consistent manner. More elaboration of the crab distribution- salinity model, especially concerning salinity and the movements of 1+ crab, is needed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.A31I0183T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.A31I0183T"><span>Improving Estimates of <span class="hlt">Entrainment</span> Mixing, Subsidence, and Photochemical Ozone Production using Aircraft and Ozone lidar during the California Baseline Ozone Transport Study (CABOTS)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Trousdell, J.; Caputi, D.; Faloona, I. C.; Conley, S. A.; Langford, A. O.; Senff, C. J.</p> <p>2016-12-01</p> <p>In situ flight data collected in the San Joaquin Valley of California during the summer of 2016 is used to measure <span class="hlt">entrainment</span> rates, ozone photochemical production, and regional methane and NOx emissions. The San Joaquin Valley is plagued with <span class="hlt">air</span> quality issues including a high frequency of ozone exceedances in the summer and an aerosol issue in the winter exacerbated by a complex meso-scale environment. The flights were conducted during the California Baseline Ozone Transport Study (CABOTS), and span the valley between the cities of Fresno and Visalia with a thorough probing of the atmospheric boundary layer (ABL) including vertical profiling to diagnose the growth rate and horizontal gradients in ABL height. <span class="hlt">Entrainment</span> velocities, which are the parameterized mixing of free tropospheric <span class="hlt">air</span> into the boundary layer, are determined by a detailed budget equation of the inversion height. Subsidence, which is essential to our determination of <span class="hlt">entrainment</span> velocity, is diagnosed by way of descending ozone laminae in the region above the ABL. The subsiding laminae are located within the flight data and corroborated by the Tunable Optical Profiler for Aerosol and oZone (TOPAZ) lidar measurements in Visalia. A novel scalar budgeting technique is then applied to expose residual terms of individual equations that amount to ozone photochemical production and emission rates. The budget equations are closed by our estimated <span class="hlt">entrainment</span> velocities, in conjunction with the time rates of change (storage) and horizontal advection all determined via flight data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..1912809S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..1912809S"><span>Wind Shear Effects within the <span class="hlt">Entrainment</span> Zone of Stratocumulus</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Schulz, Bernhard; Mellado, Juan-Pedro</p> <p>2017-04-01</p> <p>Stratocumulus clouds are crucial for the Earth's radiative budget and are hence thought to be important for understanding climate change. Still, atmospheric models suffer from order-one uncertainties associated with these clouds. Cloud-top <span class="hlt">entrainment</span> is particularly challenging because of the small-scales associated with it. Convective instabilities driven by evaporative and radiative cooling of the stratocumulus cloud-top set a continuous encroachment of the cloud layer into the <span class="hlt">entrainment</span> interfacial layer (EIL), a process defining the <span class="hlt">entrainment</span> velocity. Wind shear might play an important role in enhancing the <span class="hlt">entrainment</span> velocity, but has been largely overlooked in the past decades. Therefore, direct numerical simulations focusing on meter and sub-meter scales are used to investigate the interaction between a mean vertical shear and the <span class="hlt">entrainment</span> velocity. Our main findings are as follows. First, wind shear effects stay localized within the EIL, whose thickness is proportional to the shear layer thickness. This implies that the in-cloud turbulent state is independent of the imposed wind shear as long as the EIL is much thinner than the cloud layer. Therefore, a strong mean wind shear does not necessarily weaken the in-cloud turbulent state by depleting the cloud, which contradicts conjectures based on previous large eddy simulations. Second, a critical nondimensional shear number Scrit exits, such that no significant additional cloud-top cooling is created for S < Scrit, showing that wind shear effects are negligible in this regime. In contrast, a strong wind shear with S > Scrit enhances cloud-top cooling significantly by amplifying radiative and evaporative cooling. For typical atmospheric conditions with a strong capping inversion, Scrit corresponds to a shear velocity of 1 - 2ms-1. Consequently, large scale convective motions inside the cloud layer, associated with velocities of ˜ 1ms-1, are unable to significantly enhance cloud-top forcing of the in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4700964','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4700964"><span>Extensive <span class="hlt">Admixture</span> and Selective Pressure Across the Sahel Belt</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Triska, Petr; Soares, Pedro; Patin, Etienne; Fernandes, Veronica; Cerny, Viktor; Pereira, Luisa</p> <p>2015-01-01</p> <p>Genome-wide studies of African populations have the potential to reveal powerful insights into the evolution of our species, as these diverse populations have been exposed to intense selective pressures imposed by infectious diseases, diet, and environmental factors. Within Africa, the Sahel Belt extensively overlaps the geographical center of several endemic infections such as malaria, trypanosomiasis, meningitis, and hemorrhagic fevers. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian populations, which together with published data cover Western, Central, and Eastern Sahel, and include both nomadic and sedentary groups. We confirmed the role of this Belt as a main corridor for human migrations across the continent. Strong <span class="hlt">admixture</span> was observed in both Central and Eastern Sahelian populations, with North Africans and Near Eastern/Arabians, respectively, but it was inexistent in Western Sahelian populations. Genome-wide local ancestry inference in admixed Sahelian populations revealed several candidate regions that were significantly enriched for non-autochthonous haplotypes, and many showed to be under positive selection. The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry. Signals of positive selection varied in terms of geographic amplitude. Some genomic regions were selected across the Belt, the most striking example being the malaria-related DARC gene. Others were Western-specific (oxytocin, calcium, and heart pathways), Eastern-specific (lipid pathways), or even population-restricted (TAS2R genes in Fulani, which may reflect sexual selection). PMID:26614524</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3967955','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3967955"><span>Worldwide Patterns of Ancestry, Divergence, and <span class="hlt">Admixture</span> in Domesticated Cattle</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Decker, Jared E.; McKay, Stephanie D.; Rolf, Megan M.; Kim, JaeWoo; Molina Alcalá, Antonio; Sonstegard, Tad S.; Hanotte, Olivier; Götherström, Anders; Seabury, Christopher M.; Praharani, Lisa; Babar, Masroor Ellahi; Correia de Almeida Regitano, Luciana; Yildiz, Mehmet Ali; Heaton, Michael P.; Liu, Wan-Sheng; Lei, Chu-Zhao; Reecy, James M.; Saif-Ur-Rehman, Muhammad; Schnabel, Robert D.; Taylor, Jeremy F.</p> <p>2014-01-01</p> <p>The domestication and development of cattle has considerably impacted human societies, but the histories of cattle breeds and populations have been poorly understood especially for African, Asian, and American breeds. Using genotypes from 43,043 autosomal single nucleotide polymorphism markers scored in 1,543 animals, we evaluate the population structure of 134 domesticated bovid breeds. Regardless of the analytical method or sample subset, the three major groups of Asian indicine, Eurasian taurine, and African taurine were consistently observed. Patterns of geographic dispersal resulting from co-migration with humans and exportation are recognizable in phylogenetic networks. All analytical methods reveal patterns of hybridization which occurred after divergence. Using 19 breeds, we map the cline of indicine introgression into Africa. We infer that African taurine possess a large portion of wild African auroch ancestry, causing their divergence from Eurasian taurine. We detect exportation patterns in Asia and identify a cline of Eurasian taurine/indicine hybridization in Asia. We also identify the influence of species other than Bos taurus taurus and B. t. indicus in the formation of Asian breeds. We detect the pronounced influence of Shorthorn cattle in the formation of European breeds. Iberian and Italian cattle possess introgression from African taurine. American Criollo cattle originate from Iberia, and not directly from Africa with African ancestry inherited via Iberian ancestors. Indicine introgression into American cattle occurred in the Americas, and not Europe. We argue that cattle migration, movement and trading followed by <span class="hlt">admixture</span> have been important forces in shaping modern bovine genomic variation. PMID:24675901</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21115650','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21115650"><span><span class="hlt">Admixture</span> mapping of lung cancer in 1812 African-Americans.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schwartz, Ann G; Wenzlaff, Angela S; Bock, Cathryn H; Ruterbusch, Julie J; Chen, Wei; Cote, Michele L; Artis, Amanda S; Van Dyke, Alison L; Land, Susan J; Harris, Curtis C; Pine, Sharon R; Spitz, Margaret R; Amos, Christopher I; Levin, Albert M; McKeigue, Paul M</p> <p>2011-03-01</p> <p>Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most recently genome-wide association studies (GWAS). The African-American population has been underrepresented in these genetic studies and has patterns of cigarette use and linkage disequilibrium that differ from patterns in other populations. Therefore, studies in African-Americans can provide complementary data to localize lung cancer susceptibility genes and explore smoking dependence-related genes. We used <span class="hlt">admixture</span> mapping to further characterize genetic risk of lung cancer in a series of 837 African-American lung cancer cases and 975 African-American controls genotyped at 1344 ancestry informative single-nucleotide polymorphisms. Both case-only and case-control analyses were conducted using ADMIXMAP adjusted for age, sex, pack-years of smoking, family history of lung cancer, history of emphysema and study site. In case-only analyses, excess European ancestry was observed over a wide region on chromosome 1 with the largest excess seen at rs6587361 for non-small-cell lung cancer (NSCLC) (Z-score = -4.33; P = 1.5 × 10⁻⁵) and for women with NSCLC (Z-score = -4.82; P = 1.4 × 10⁻⁶). Excess African ancestry was also observed on chromosome 3q with a peak Z-score of 3.33 (P = 0.0009) at rs181696 among ever smokers with NSCLC. These results add to the findings from the GWAS in Caucasian populations and suggest novel regions of interest.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4583808','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4583808"><span><span class="hlt">Admixture</span> mapping of genetic variants for uterine fibroids</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhang, Kui; Wiener, Howard; Aissani, Brahim</p> <p>2015-01-01</p> <p>Uterine leiomyoma (UL) are benign neoplasms arising from the smooth muscle cells of the uterus. One of the established risk factors for UL is African American ethnicity. Studies have consistently shown that African Americans have 2-3 times higher risk compared with that of non-Hispanic Whites. However, there is still no adequate explanation for the higher risk among African Americans. To investigate the genetic contribution to the observed difference between the African American and European American populations, we conducted an <span class="hlt">admixture</span> scan in 525 eligible African American women participants to the NIEHS uterine fibroid study (NIEHS-UFS). In models with no stratification, we found multiple genomic regions showing significant and suggestive evidence of association, with chromosomal band 2q32.2 at rs256552 showing the highest score (Z-score = 7.86, Bonferroni adjusted p-value = 5.5×10-12) consistent with the suggestive evidence reported for this genomic region in the Black Women's Health Study. However, in models stratified by the body mass index (BMI) covariate, chromosomal 1q42.2 was the sole genomic region that consistently showed suggestive associations across the BMI categories tested (Z-scores ≤ -3.96, Bonferroni adjusted p-values ≤ 0.107). In age-stratified models, a significant association was observed in the older category (age > 40) reaching a Z-score of 6.44 (Bonferroni-adjusted p-value = 1.64 × 10-7) at rs256552. The mean percentage of European ancestry among cases was lower than that among controls in the NIEHS-UFS study. However, our study did not show a significant association between mean percentage of European ancestry and UL. PMID:26040208</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4014568','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4014568"><span>Implications of the <span class="hlt">Admixture</span> Process in Skin Color Molecular Assessment</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>de Cerqueira, Caio Cesar Silva; Hünemeier, Tábita; Gomez-Valdés, Jorge; Ramallo, Virgínia; Volasko-Krause, Carla Daiana; Barbosa, Ana Angélica Leal; Vargas-Pinilla, Pedro; Dornelles, Rodrigo Ciconet; Longo, Danaê; Rothhammer, Francisco; Bedoya, Gabriel; Canizales-Quinteros, Samuel; Acuña-Alonzo, Victor; Gallo, Carla; Poletti, Giovanni; González-José, Rolando; Salzano, Francisco Mauro; Callegari-Jacques, Sídia Maria; Schuler-Faccini, Lavínia; Ruiz-Linares, Andrés; Cátira Bortolini, Maria</p> <p>2014-01-01</p> <p>The understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes have previously been associated with human skin color, knowledge about this trait remains incomplete. In particular, studies focusing on populations outside the European-North American axis are rare, and, until now, admixed populations have seldom been considered. The present study was designed to help fill this gap. Our objective was to evaluate possible associations of 18 single nucleotide polymorphisms (SNPs), located within nine genes, and one pseudogene with the Melanin Index (MI) in two admixed Brazilian populations (Gaucho, N = 352; Baiano, N = 148) with different histories of geographic and ethnic colonization. Of the total sample, four markers were found to be significantly associated with skin color, but only two (SLC24A5 rs1426654, and SLC45A2 rs16891982) were consistently associated with MI in both samples (Gaucho and Baiano). Therefore, only these 2 SNPs should be preliminarily considered to have forensic significance because they consistently showed the association independently of the <span class="hlt">admixture</span> level of the populations studied. We do not discard that the other two markers (HERC2 rs1129038 and TYR rs1126809) might be also relevant to admixed samples, but additional studies are necessary to confirm the real importance of these markers for skin pigmentation. Finally, our study shows associations of some SNPs with MI in a modern Brazilian admixed sample, with possible applications in forensic genetics. Some classical genetic markers in Euro-North American populations are not associated with MI in our sample. Our results point out the relevance of considering population differences in selecting an appropriate set of SNPs as phenotype predictors in forensic practice. PMID:24809478</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24809478','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24809478"><span>Implications of the <span class="hlt">admixture</span> process in skin color molecular assessment.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cerqueira, Caio Cesar Silva de; Hünemeier, Tábita; Gomez-Valdés, Jorge; Ramallo, Virgínia; Volasko-Krause, Carla Daiana; Barbosa, Ana Angélica Leal; Vargas-Pinilla, Pedro; Dornelles, Rodrigo Ciconet; Longo, Danaê; Rothhammer, Francisco; Bedoya, Gabriel; Canizales-Quinteros, Samuel; Acuña-Alonzo, Victor; Gallo, Carla; Poletti, Giovanni; González-José, Rolando; Salzano, Francisco Mauro; Callegari-Jacques, Sídia Maria; Schuler-Faccini, Lavínia; Ruiz-Linares, Andrés; Cátira Bortolini, Maria</p> <p>2014-01-01</p> <p>The understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes have previously been associated with human skin color, knowledge about this trait remains incomplete. In particular, studies focusing on populations outside the European-North American axis are rare, and, until now, admixed populations have seldom been considered. The present study was designed to help fill this gap. Our objective was to evaluate possible associations of 18 single nucleotide polymorphisms (SNPs), located within nine genes, and one pseudogene with the Melanin Index (MI) in two admixed Brazilian populations (Gaucho, N = 352; Baiano, N = 148) with different histories of geographic and ethnic colonization. Of the total sample, four markers were found to be significantly associated with skin color, but only two (SLC24A5 rs1426654, and SLC45A2 rs16891982) were consistently associated with MI in both samples (Gaucho and Baiano). Therefore, only these 2 SNPs should be preliminarily considered to have forensic significance because they consistently showed the association independently of the <span class="hlt">admixture</span> level of the populations studied. We do not discard that the other two markers (HERC2 rs1129038 and TYR rs1126809) might be also relevant to admixed samples, but additional studies are necessary to confirm the real importance of these markers for skin pigmentation. Finally, our study shows associations of some SNPs with MI in a modern Brazilian admixed sample, with possible applications in forensic genetics. Some classical genetic markers in Euro-North American populations are not associated with MI in our sample. Our results point out the relevance of considering population differences in selecting an appropriate set of SNPs as phenotype predictors in forensic practice.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26993256','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26993256"><span>The Complex <span class="hlt">Admixture</span> History and Recent Southern Origins of Siberian Populations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pugach, Irina; Matveev, Rostislav; Spitsyn, Viktor; Makarov, Sergey; Novgorodov, Innokentiy; Osakovsky, Vladimir; Stoneking, Mark; Pakendorf, Brigitte</p> <p>2016-07-01</p> <p>Although Siberia was inhabited by modern humans at an early stage, there is still debate over whether it remained habitable during the extreme cold of the Last Glacial Maximum or whether it was subsequently repopulated by peoples with recent shared ancestry. Previous studies of the genetic history of Siberian populations were hampered by the extensive <span class="hlt">admixture</span> that appears to have taken place among these populations, because commonly used methods assume a tree-like population history and at most single <span class="hlt">admixture</span> events. Here we analyze geogenetic maps and use other approaches to distinguish the effects of shared ancestry from prehistoric migrations and contact, and develop a new method based on the covariance of ancestry components, to investigate the potentially complex <span class="hlt">admixture</span> history. We furthermore adapt a previously devised method of <span class="hlt">admixture</span> dating for use with multiple events of gene flow, and apply these methods to whole-genome genotype data from over 500 individuals belonging to 20 different Siberian ethnolinguistic groups. The results of these analyses indicate that there have been multiple layers of <span class="hlt">admixture</span> detectable in most of the Siberian populations, with considerable differences in the <span class="hlt">admixture</span> histories of individual populations. Furthermore, most of the populations of Siberia included here, even those settled far to the north, appear to have a southern origin, with the northward expansions of different populations possibly being driven partly by the advent of pastoralism, especially reindeer domestication. These newly developed methods to analyze multiple <span class="hlt">admixture</span> events should aid in the investigation of similarly complex population histories elsewhere. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3487126','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3487126"><span>Exploring Population <span class="hlt">Admixture</span> Dynamics via Empirical and Simulated Genome-wide Distribution of Ancestral Chromosomal Segments</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jin, Wenfei; Wang, Sijia; Wang, Haifeng; Jin, Li; Xu, Shuhua</p> <p>2012-01-01</p> <p>The processes of genetic <span class="hlt">admixture</span> determine the haplotype structure and linkage disequilibrium patterns of the admixed population, which is important for medical and evolutionary studies. However, most previous studies do not consider the inherent complexity of <span class="hlt">admixture</span> processes. Here we proposed two approaches to explore population <span class="hlt">admixture</span> dynamics, and we demonstrated, by analyzing genome-wide empirical and simulated data, that the approach based on the distribution of chromosomal segments of distinct ancestry (CSDAs) was more powerful than that based on the distribution of individual ancestry proportions. Analysis of 1,890 African Americans showed that a continuous gene flow model, in which the African American population continuously received gene flow from European populations over about 14 generations, best explained the <span class="hlt">admixture</span> dynamics of African Americans among several putative models. Interestingly, we observed that some African Americans had much more European ancestry than the simulated samples, indicating substructures of local ancestries in African Americans that could have been caused by individuals from some particular lineages having repeatedly admixed with people of European ancestry. In contrast, the <span class="hlt">admixture</span> dynamics of Mexicans could be explained by a gradual <span class="hlt">admixture</span> model in which the Mexican population continuously received gene flow from both European and Amerindian populations over about 24 generations. Our results also indicated that recent gene flows from Sub-Saharan Africans have contributed to the gene pool of Middle Eastern populations such as Mozabite, Bedouin, and Palestinian. In summary, this study not only provides approaches to explore population <span class="hlt">admixture</span> dynamics, but also advances our understanding on population history of African Americans, Mexicans, and Middle Eastern populations. PMID:23103229</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1738223','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1738223"><span>Emulsion stability in total nutrient <span class="hlt">admixtures</span> containing a pediatric amino acid formulation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bullock, L; Fitzgerald, J F; Walter, W V</p> <p>1992-01-01</p> <p>Emulsion stability of total nutrient <span class="hlt">admixtures</span> containing TrophAmine amino acid injection admixed with Intralipid, Nutrilipid, and Liposyn II was studied. High and low electrolyte concentrations were added to each total nutrient <span class="hlt">admixture</span> before storage at 4 degrees C for 48 hours then at 20-22 degrees C for 24 hours. Stability studies were also performed on total nutrient <span class="hlt">admixtures</span> containing higher concentrations of fat emulsion and total nutrient <span class="hlt">admixtures</span> with added cysteine hydrochloride and carnitine. High electrolyte concentrations only were added to these total nutrient <span class="hlt">admixtures</span> before being stored refrigerated for 24 hours then at room temperature for 24 hours. Visual assessment, pH determination, and particle size analysis were performed immediately after compounding and after refrigerated and room temperature storage. Particle size was assessed by measuring the mean diameter of the fat emulsion and the percent of oil volume in particles greater than 5 microns. Repeated-measures analyses of variance were used to determine significance of type or concentration of fat emulsion, electrolyte concentrations, or time on mean diameter or percent particles greater than 5 microns. There were minimal changes in pH values over time. Creaming was observed in all total nutrient <span class="hlt">admixtures</span> at all sampling times except time zero. This was reversible upon agitation. Results of particle size analysis over time indicated little change in mean diameter or percent particles greater than 5 microns. These minimal changes did not seem to be clinically significant. It is concluded that total nutrient <span class="hlt">admixtures</span> prepared with this pediatric amino acid formulation are stable when prepared and stored as reported.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22739346','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22739346"><span>Inferring separate parental <span class="hlt">admixture</span> components in unknown DNA samples using autosomal SNPs.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Crouch, Daniel J M; Weale, Michael E</p> <p>2012-12-01</p> <p>The identification of ancestral <span class="hlt">admixture</span> proportions for human DNA samples has recently had success in forensic cases. Current methods infer <span class="hlt">admixture</span> proportions for the target sample, but not for their parents, which provides an additional layer of information that may aid certain forensic investigations. We describe new maximum likelihood methods (LEAPFrOG and LEAPFrOG Expectation Maximisation), for inferring both an individual's <span class="hlt">admixture</span> proportions and the <span class="hlt">admixture</span> proportions possessed by the unobserved parents, with respect to two or more source populations, using single-nucleotide polymorphism data typed only in the target individual. This is achieved by examining the increase in heterozygosity in the offspring of parents who are from different populations or who represent different mixtures from a number of source populations. We validated the methods via simulation; combining chromosomes from different Hapmap Phase III population samples to emulate first-generation <span class="hlt">admixture</span>. Performance was strong for individuals with mixed African/European (YRI/CEU) ancestry, but poor for mixed Japanese/Chinese (JPT/CHB) ancestry, reflecting the difficulty in distinguishing closely related source populations. A total of 11 African-American trios were used to compare the parental <span class="hlt">admixture</span> inferred from their own genotypes against that inferred purely from their offspring genotypes. We examined the performance of 34 ancestry informative markers from a multiplex kit for ancestry inference. Simulations showed that estimates were unreliable when parents had similar <span class="hlt">admixture</span>, suggesting more markers are needed. Our results demonstrate that ancestral backgrounds of case samples and their parents are obtainable to aid in forensic investigations, provided that high-throughput methods are adopted by the forensic community.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA446853','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA446853"><span>Extending the Season for Concrete Construction and Repair. Phase II - Defining Engineering Parameters</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2006-04-01</p> <p><span class="hlt">admixture</span>- free concrete , a high percentage of the mixing water will immediately turn into ice and structural damage is likely. Table 6. Freezing...problem. Because only <span class="hlt">air</span> content was the issue and because <span class="hlt">air</span> contents were easier to manage in <span class="hlt">admixture</span>- free concrete , <span class="hlt">air-entrained</span> control mortar... concrete . 6. The dosage of the MB IV <span class="hlt">admixture</span> required to protect fresh concrete against freezing down to –5°C is around 12% by weight of free water in</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011AGUFMEP31E0869F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011AGUFMEP31E0869F"><span>Landslide boost from <span class="hlt">entrainment</span> of erodible material along the slope</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Farin, M.; Mangeney, A.; Roche, O.; Ionescu, I.; Hungr, O.</p> <p>2011-12-01</p> <p>Landslides, debris flows, pyroclastic flows and avalanches are natural hazards that threaten life and property in mountainous, volcanic, coastal and seismically active areas. The granular mass tends to accelerate as gravity pulls it down the slope, and will slow on more gentle slopes, when interaction forces dissipating energy overcome the driving forces. The <span class="hlt">entrainment</span> of underlying sediments or debris into the gravitational granular flows is suspected to be critical to their dynamics, but direct measurement of material <span class="hlt">entrainment</span> in natural flows is very difficult. Nevertheless, qualitative and quantitative field observations suggest that material <span class="hlt">entrainment</span> can either increase or decrease flow velocity and deposit extent, depending on the geological setting and the type of gravitational flow. Based on laboratory experiments on dry granular flows, we show here that erosion of granular material already present on the bed can significantly increase the size and mobility of the flow and possibly generate surges. We present laboratory experiments of granular material flowing over an inclined plane covered by an erodible bed, designed to mimic erosion processes of natural flows traveling over deposits built up by earlier events. The controlling parameters are the inclination of the plane and the thickness of the erodible layer. Different methods are used to prepare the erodible bed, thus leading to various degrees of compaction. We show that erosion processes increases the flow mobility (i. e. runout) by up to 40 % over slopes with inclination close to the repose angle of the grains. The effect is observed even for very thin erodible beds. We demonstrate that the increase of mass of the flowing grains caused by <span class="hlt">entrainment</span> of the erodible layer is not enough to explain the observed increase in velocity and runout of the granular mass. Erosion efficiency is shown to strongly depend on the slope and on the nature (i. e. degree of compaction) of the erodible bed</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16621256','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16621256"><span>Investigation of <span class="hlt">entrainment</span> and thermal properties of a cryogenic dense-gas cloud using optical measurement techniques.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kunsch, J P; Rösgen, T</p> <p>2006-09-01</p> <p>Cryogenic dense-gas clouds have been investigated in a heavy-gas channel under controlled source and ambient conditions. Advantage is taken from new, non-intrusive optical measurement techniques (e.g. image correlation velocimetry, ICV, and background oriented Schlieren, BOS) providing detailed pictures of the temperature and velocity field in relevant regions of the cloud. The ice particles in the cloud, formed by nucleation, represent a natural seeding to be used as tracers, which have the advantage of behaving passively. Two layers can be identified in a cryogenic gas cloud: a lower cold layer, which is visible due to the presence of ice particles, and an invisible upper layer, where the ice particles have melted, mostly due to heat addition by <span class="hlt">air</span> <span class="hlt">entrainment</span> into the upper layer. A two-layer model has been applied to a generic element of the cloud, where detailed experimental data regarding velocity and temperature are available. Thermal- and dilution behaviour can be interpreted by means of the model which is presented in detail. A global <span class="hlt">entrainment</span> parameter is deduced allowing a simple comparison with existing experimental information obtained by other traditional experimental techniques. The numerical values of the present <span class="hlt">entrainment</span> parameter agree well with the correlations proposed by other authors. Thermal effects, such as heat transfer from the ground, appear to be very important. In addition, the visible height of the cloud can be predicted in relative good agreement with the experimental observations, by means of a thermal balance including the phase transition of the ice particles.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20100030597','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20100030597"><span>Combustion Model of Supersonic Rocket Exhausts in an <span class="hlt">Entrained</span> Flow Enclosure</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Vu, Bruce; Oliveira, Justin</p> <p>2011-01-01</p> <p>This paper describes the Computation Fluid Dynamics (CFD) model developed to simulate the supersonic rocket exhaust in an <span class="hlt">entrained</span> flow cylinder. The model can be used to study the plume-induced environment due to static firing test of the Taurus II launch vehicle. The finite rate chemistry is used to model the combustion process involving rocket propellant (RP 1) and liquid oxidizer (LOX). A similar chemical reacting model is also used to simulate the mixing of rocket plume and ambient <span class="hlt">air</span>. The model provides detailed information on the gas concentration and other flow parameters within the enclosed region thus allowing different operating scenarios to be examined in an efficient manner. It is shown that the real gas influence is significant and yields better agreement with the theory.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110016721','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110016721"><span>Combustion Model of Supersonic Rocket Exhausts in an <span class="hlt">Entrained</span> Flow Enclosure</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Vu, Bruce T.; Oliveira, Justin</p> <p>2011-01-01</p> <p>This paper describes the Computational Fluid Dynamics (CFD) model developed to simulate the supersonic rocket exhaust in an <span class="hlt">entrained</span> flow cylinder. The model can be used to study the plume-induced environment due to static firing tests of the Taurus-II launch vehicle. The finite-rate chemistry is used to model the combustion process involving rocket propellant (RP-1) and liquid oxidizer (LOX). A similar chemical reacting model is also used to simulate the mixing of rocket plume and ambient <span class="hlt">air</span>. The model provides detailed information on the gas concentration and other flow parameters within the enclosed region, thus allowing different operating scenarios to be examined in an efficient manner. It is shown that the real gas influence is significant and yields better agreement with the theory.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/20885876','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/20885876"><span>Mathematical modeling of heat exchange between mine <span class="hlt">air</span> and rock mass during fire</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>A.E. Krasnoshtein; B.P. Kazakov; A.V. Shalimov</p> <p>2006-05-15</p> <p>Solution of problems on heat exchange between ventilating <span class="hlt">air</span> and rock mass and on gas <span class="hlt">admixture</span> propagation in mine workings serve as a base for considering changes in heat-gas-<span class="hlt">air</span> state at a mine after inflammation. The presented mathematical relations allow calculation of a varied velocity and movement direction of <span class="hlt">air</span> flows, their temperatures and smoking conditions during fire.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/5319024','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/5319024"><span>Numerical model of wind-induced <span class="hlt">entrainment</span> in a double-diffusive thermohaline system</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Hullender, T.A.; Laster, W.R. . School of Mechanical Engineering)</p> <p>1994-01-01</p> <p>A low Reynolds number k-[epsilon] model has been used to predict the wind-induced <span class="hlt">entrainment</span> in a double-diffusive system. The calculated results are compared with experimental results from wind-induced <span class="hlt">entrainment</span> in a finite length tank and with shear-induced <span class="hlt">entrainment</span> in an annular tank. Overall agreement is good for wind speeds less than 10 m/s. Above this value, multidimensional effects tend to dominate. The scale of the turbulence at the surface is found to significantly affect the <span class="hlt">entrainment</span> rate. This indicates that the suppression of waves on the surface can significantly reduce the rate of <span class="hlt">entrainment</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/6908117','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/6908117"><span>Gradient layer <span class="hlt">entrainment</span> in a thermohaline system with mixed layer circulation</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Incropera, F.P.; Lents, C.E.; Viskanta, R.</p> <p>1986-11-01</p> <p><span class="hlt">Entrainment</span> of salt-stratified fluid into a bottom mixed layer is investigated under conditions for which mixing is driven by bottom heating and/or an imposed horizontal flow. <span class="hlt">Entrainment</span> rate measurements and mixed layer flow visualization suggest that <span class="hlt">entrainment</span> is strongly influenced by a shear mechanism involving both horizontal and vertical fluid velocity components. Under certain conditions, imposition of the horizontal flow inhibits the buoyancy flow and <span class="hlt">entrainment</span> rates for combined mixing are less than those for pure buoyant mixing. Attempts to correlate <span class="hlt">entrainment</span> rates in terms of conventional dimensionless parameters were unsuccessful.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19810021591','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19810021591"><span><span class="hlt">Entrainment</span> and thrust augmentation in pulsatile ejector flows</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Sarohia, V.; Bernal, L.; Bui, T.</p> <p>1981-01-01</p> <p>This study comprised direct thrust measurements, flow visualization by use of a spark shadowgraph technique, and mean and fluctuating velocity measurements with a pitot tube and linearized constant temperature hot-wire anemometry respectively. A gain in thrust of as much as 10 to 15% was observed for the pulsatile ejector flow as compared to the steady flow configuration. From the velocity profile measurements, it is concluded that this enhanced augmentation for pulsatile flow as compared to a nonpulsatile one was accomplished by a corresponding increased <span class="hlt">entrainment</span> by the primary jet flow. It is also concluded that the augmentation and total <span class="hlt">entrainment</span> by a constant area ejector critically depends upon the inlet geometry of the ejector. Experiments were performed to evaluate the influence of primary jet to ejector area ratio, ejector length, and presence of a diffuser on pulsatile ejector performance.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/20771496','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/20771496"><span><span class="hlt">Entrainment</span> parameters in a cold superfluid neutron star core</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Chamel, Nicolas; Haensel, Pawel</p> <p>2006-04-15</p> <p>Hydrodynamic simulations of neutron star cores that are based on a two-fluid description in terms of a neutron-proton superfluid mixture require the knowledge of the Andreev-Bashkin <span class="hlt">entrainment</span> matrix which relates the momentum of one constituent to the currents of both constituents. This matrix is derived for arbitrary nuclear asymmetry at zero temperature and in the limits of small relative currents in the framework of the energy density functional theory. The Skyrme energy density functional is considered as a particular case. General analytic formulas for the <span class="hlt">entrainment</span> parameters and various corresponding effective masses are obtained. These formulas are applied to the liquid core of a neutron star composed of homogeneous plasma of nucleons, electrons, and possibly muons in {beta} equilibrium.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MNRAS.452.3246P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MNRAS.452.3246P"><span>Magnetized neutron stars with superconducting cores: effect of <span class="hlt">entrainment</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Palapanidis, K.; Stergioulas, N.; Lander, S. K.</p> <p>2015-09-01</p> <p>We construct equilibrium configurations of magnetized, two-fluid neutron stars using an iterative numerical method. Working in Newtonian framework we assume that the neutron star has two regions: the core, which is modelled as a two-component fluid consisting of type-II superconducting protons and superfluid neutrons, and the crust, a region composed of normal matter. Taking a new step towards more complete equilibrium models, we include the effect of <span class="hlt">entrainment</span>, which implies that a magnetic force acts on neutrons, too. We consider purely poloidal field cases and present improvements to an earlier numerical scheme for solving equilibrium equations, by introducing new convergence criteria. We find that <span class="hlt">entrainment</span> results in qualitative differences in the structure of field lines along the magnetic axis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2706452','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2706452"><span>Synchrony and <span class="hlt">entrainment</span> properties of robust circadian oscillators</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bagheri, Neda; Taylor, Stephanie R.; Meeker, Kirsten; Petzold, Linda R.; Doyle, Francis J.</p> <p>2008-01-01</p> <p>Systems theoretic tools (i.e. mathematical modelling, control, and feedback design) advance the understanding of robust performance in complex biological networks. We highlight phase <span class="hlt">entrainment</span> as a key performance measure used to investigate dynamics of a single deterministic circadian oscillator for the purpose of generating insight into the behaviour of a population of (synchronized) oscillators. More specifically, the analysis of phase characteristics may facilitate the identification of appropriate coupling mechanisms for the ensemble of noisy (stochastic) circadian clocks. Phase also serves as a critical control objective to correct mismatch between the biological clock and its environment. Thus, we introduce methods of investigating synchrony and <span class="hlt">entrainment</span> in both stochastic and deterministic frameworks, and as a property of a single oscillator or population of coupled oscillators. PMID:18426774</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19123630','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19123630"><span>Improvements and applications of <span class="hlt">entrainment</span> control for nonlinear dynamical systems.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liu, Fang; Song, Qiang; Cao, Jinde</p> <p>2008-12-01</p> <p>This paper improves the existing <span class="hlt">entrainment</span> control approaches and develops unified schemes to chaos control and generalized (lag, anticipated, and complete) synchronization of nonlinear dynamical systems. By introducing impulsive effects to the open-loop control method, we completely remove its restrictions on goal dynamics and initial conditions, and derive a sufficient condition to estimate the upper bound of impulsive intervals to ensure the global asymptotic stability. We then propose two effective ways to implement the <span class="hlt">entrainment</span> strategy which combine open-loop and closed-loop control, and we prove that the feedback gains can be chosen according to a lower bound or be tuned with an adaptive control law. Numerical examples are given to verify the theoretical results and to illustrate their applications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013EGUGA..1511780M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013EGUGA..1511780M"><span>Numerical Modeling of Deep Mantle Flow: Thermochemical Convection and <span class="hlt">Entrainment</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mulyukova, Elvira; Steinberger, Bernhard; Dabrowski, Marcin; Sobolev, Stephan</p> <p>2013-04-01</p> <p>One of the most robust results from tomographic studies is the existence of two antipodally located Large Low Shear Velocity Provinces (LLSVPs) at the base of the mantle, which appear to be chemically denser than the ambient mantle. Results from reconstruction studies (Torsvik et al., 2006) infer that the LLSVPs are stable, long-lived, and are sampled by deep mantle plumes that rise predominantly from their margins. The origin of the dense material is debated, but generally falls within three categories: (i) a primitive layer that formed during magma ocean crystallization, (ii) accumulation of a dense eclogitic component from the recycled oceanic crust, and (iii) outer core material leaking into the lower mantle. A dense layer underlying a less dense ambient mantle is gravitationally stable. However, the flow due to thermal density variations, i.e. hot rising plumes and cold downwelling slabs, may deform the layer into piles with higher topography. Further deformation may lead to <span class="hlt">entrainment</span> of the dense layer, its mixing with the ambient material, and even complete homogenisation with the rest of the mantle. The amount of the anomalous LLSVP-material that gets <span class="hlt">entrained</span> into the rising plumes poses a constraint on the survival time of the LLSVPs, as well as on the plume buoyancy, on the lithospheric uplift associated with plume interaction and geochemical signature of the erupted lavas observed at the Earth's surface. Recent estimates for the plume responsible for the formation of the Siberian Flood Basalts give about 15% of <span class="hlt">entrained</span> dense recycled oceanic crust, which made the hot mantle plume almost neutrally buoyant (Sobolev et al., 2011). In this numerical study we investigate the mechanics of <span class="hlt">entrainment</span> of a dense basal layer by convective mantle flow. We observe that the types of flow that promote <span class="hlt">entrainment</span> of the dense layer are (i) upwelling of the dense layer when it gets heated enough to overcome its stabilizing chemical density anomaly, (ii</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456505','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456505"><span>Effect of Gum Arabic karroo as a Water-Reducing <span class="hlt">Admixture</span> in Concrete</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mbugua, Rose; Salim, Ramadhan; Ndambuki, Julius</p> <p>2016-01-01</p> <p>Concrete is one of the most popular construction materials in the world. Chemical <span class="hlt">admixtures</span> are ingredients added to concrete to enhance its properties. However, most chemical <span class="hlt">admixtures</span> on the market today are expensive, thereby making them out of reach for small consumers of concrete. In Africa, use of chemical <span class="hlt">admixtures</span> is rare despite the harsh weather conditions. In the current study, Gum from Acacia karroo (GAK) was used as a water-reducing <span class="hlt">admixture</span> in concrete. A slump test, density and compressive strength were studied using different dosages of GAK while neat concrete was the control. Results showed that slump increased by 200% at a 2% dosage of GAK. This enabled reduction of water-to-binder (w/b) ratio from 0.61 to 0.48 for samples with a 3% dosage. Reduction in w/b resulted in increased compressive strength of 37.03% above the control after 180 days of curing for a 3% dosage. XRD studies also showed a decreased rate of hydration in the presence of GAK in concrete. It was concluded that GAK can be used in concrete as a water-reducing <span class="hlt">admixture</span>, which is environmentally-friendly, thus producing sustainable and greener concrete. PMID:28787879</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5380316','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5380316"><span>The time and place of European <span class="hlt">admixture</span> in Ashkenazi Jewish history</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Xue, James; Lencz, Todd; Darvasi, Ariel; Pe’er, Itsik</p> <p>2017-01-01</p> <p>The Ashkenazi Jewish (AJ) population is important in genetics due to its high rate of Mendelian disorders. AJ appeared in Europe in the 10th century, and their ancestry is thought to comprise European (EU) and Middle-Eastern (ME) components. However, both the time and place of <span class="hlt">admixture</span> are subject to debate. Here, we attempt to characterize the AJ <span class="hlt">admixture</span> history using a careful application of new and existing methods on a large AJ sample. Our main approach was based on local ancestry inference, in which we first classified each AJ genomic segment as EU or ME, and then compared allele frequencies along the EU segments to those of different EU populations. The contribution of each EU source was also estimated using GLOBETROTTER and haplotype sharing. The time of <span class="hlt">admixture</span> was inferred based on multiple statistics, including ME segment lengths, the total EU ancestry per chromosome, and the correlation of ancestries along the chromosome. The major source of EU ancestry in AJ was found to be Southern Europe (≈60–80% of EU ancestry), with the rest being likely Eastern European. The inferred <span class="hlt">admixture</span> time was ≈30 generations ago, but multiple lines of evidence suggest that it represents an average over two or more events, pre- and post-dating the founder event experienced by AJ in late medieval times. The time of the pre-bottleneck <span class="hlt">admixture</span> event, which was likely Southern European, was estimated to ≈25–50 generations ago. PMID:28376121</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21913174','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21913174"><span>The impact of founder effects, gene flow, and European <span class="hlt">admixture</span> on native American genetic diversity.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hunley, Keith; Healy, Meghan</p> <p>2011-12-01</p> <p>Recent studies have concluded that the global pattern of neutral genetic diversity in humans reflects a series of founder effects and population movements associated with our recent expansion out of Africa. In contrast, regional studies tend to emphasize the significance of more complex patterns of colonization, gene flow, and secondary population movements in shaping patterns of diversity. Our objective in this study is to examine how founder effects, gene flow, and European <span class="hlt">admixture</span> have molded patterns of neutral genetic diversity in the Americas. Our strategy is to test the fit of a serial founder effects process to the pattern of neutral autosomal genetic variation and to examine the contribution of gene flow and European <span class="hlt">admixture</span> to departures from fit. The genetic data consist of 678 autosomal microsatellite loci assayed by Wang and colleagues in 530 individuals in 29 widely distributed Native American populations. We find that previous evidence for serial founder effects in the Americas may be driven in part by high levels of European <span class="hlt">admixture</span> in northern North America, intermediate levels in Central America, and low levels in eastern South America. Geographically patterned <span class="hlt">admixture</span> may also account for previously reported genetic differences between Andean and Amazonian groups. Though <span class="hlt">admixture</span> has obscured the precise details of precontact evolutionary processes, we find that genetic diversity is still largely hierarchically structured and that gene flow between neighboring groups has had surprisingly little impact on macrogeographic patterns of genetic diversity in the Americas. 2011 Wiley Periodicals, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28376121','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28376121"><span>The time and place of European <span class="hlt">admixture</span> in Ashkenazi Jewish history.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Xue, James; Lencz, Todd; Darvasi, Ariel; Pe'er, Itsik; Carmi, Shai</p> <p>2017-04-01</p> <p>The Ashkenazi Jewish (AJ) population is important in genetics due to its high rate of Mendelian disorders. AJ appeared in Europe in the 10th century, and their ancestry is thought to comprise European (EU) and Middle-Eastern (ME) components. However, both the time and place of <span class="hlt">admixture</span> are subject to debate. Here, we attempt to characterize the AJ <span class="hlt">admixture</span> history using a careful application of new and existing methods on a large AJ sample. Our main approach was based on local ancestry inference, in which we first classified each AJ genomic segment as EU or ME, and then compared allele frequencies along the EU segments to those of different EU populations. The contribution of each EU source was also estimated using GLOBETROTTER and haplotype sharing. The time of <span class="hlt">admixture</span> was inferred based on multiple statistics, including ME segment lengths, the total EU ancestry per chromosome, and the correlation of ancestries along the chromosome. The major source of EU ancestry in AJ was found to be Southern Europe (≈60-80% of EU ancestry), with the rest being likely Eastern European. The inferred <span class="hlt">admixture</span> time was ≈30 generations ago, but multiple lines of evidence suggest that it represents an average over two or more events, pre- and post-dating the founder event experienced by AJ in late medieval times. The time of the pre-bottleneck <span class="hlt">admixture</span> event, which was likely Southern European, was estimated to ≈25-50 generations ago.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3982695','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3982695"><span>Neandertal <span class="hlt">Admixture</span> in Eurasia Confirmed by Maximum-Likelihood Analysis of Three Genomes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lohse, Konrad; Frantz, Laurent A. F.</p> <p>2014-01-01</p> <p>Although there has been much interest in estimating histories of divergence and <span class="hlt">admixture</span> from genomic data, it has proved difficult to distinguish recent <span class="hlt">admixture</span> from long-term structure in the ancestral population. Thus, recent genome-wide analyses based on summary statistics have sparked controversy about the possibility of interbreeding between Neandertals and modern humans in Eurasia. Here we derive the probability of full mutational configurations in nonrecombining sequence blocks under both <span class="hlt">admixture</span> and ancestral structure scenarios. Dividing the genome into short blocks gives an efficient way to compute maximum-likelihood estimates of parameters. We apply this likelihood scheme to triplets of human and Neandertal genomes and compare the relative support for a model of <span class="hlt">admixture</span> from Neandertals into Eurasian populations after their expansion out of Africa against a history of persistent structure in their common ancestral population in Africa. Our analysis allows us to conclusively reject a model of ancestral structure in Africa and instead reveals strong support for Neandertal <span class="hlt">admixture</span> in Eurasia at a higher rate (3.4−7.3%) than suggested previously. Using analysis and simulations we show that our inference is more powerful than previous summary statistics and robust to realistic levels of recombination. PMID:24532731</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3899836','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3899836"><span>Assessment of coyote-wolf-dog <span class="hlt">admixture</span> using ancestry-informative diagnostic SNPs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Monzón, J.; Kays, R.; Dykhuizen, D. E.</p> <p>2014-01-01</p> <p>The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human-dominated environments. We genotyped 63 ancestry-informative single nucleotide polymorphisms in 427 canids in order to examine the prevalence, spatial distribution, and ecology of <span class="hlt">admixture</span> in eastern coyotes. Using multivariate methods and Bayesian clustering analyses, we estimated the relative contributions of western coyotes, western and eastern wolves, and domestic dogs to the admixed ancestry of Ohio and eastern coyotes. We found that eastern coyotes form an extensive hybrid swarm, with all our samples having varying levels of <span class="hlt">admixture</span>. Ohio coyotes, previously thought to be free of <span class="hlt">admixture</span>, are also highly admixed with wolves and dogs. Coyotes in areas of high deer density are genetically more wolf-like, suggesting that natural selection for wolf-like traits may result in local adaptation at a fine geographic scale. Our results, in light of other previously published studies of <span class="hlt">admixture</span> in Canis, reveal a pattern of sex-biased hybridization, presumably generated by male wolves and dogs mating with female coyotes. This study is the most comprehensive genetic survey of <span class="hlt">admixture</span> in eastern coyotes and demonstrates that the frequency and scope of hybridization can be quantified with relatively few ancestry-informative markers. PMID:24148003</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24148003','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24148003"><span>Assessment of coyote-wolf-dog <span class="hlt">admixture</span> using ancestry-informative diagnostic SNPs.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Monzón, J; Kays, R; Dykhuizen, D E</p> <p>2014-01-01</p> <p>The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human-dominated environments. We genotyped 63 ancestry-informative single-nucleotide polymorphisms in 427 canids to examine the prevalence, spatial distribution and the ecology of <span class="hlt">admixture</span> in eastern coyotes. Using multivariate methods and Bayesian clustering analyses, we estimated the relative contributions of western coyotes, western and eastern wolves, and domestic dogs to the admixed ancestry of Ohio and eastern coyotes. We found that eastern coyotes form an extensive hybrid swarm, with all our samples having varying levels of <span class="hlt">admixture</span>. Ohio coyotes, previously thought to be free of <span class="hlt">admixture</span>, are also highly admixed with wolves and dogs. Coyotes in areas of high deer density are genetically more wolf-like, suggesting that natural selection for wolf-like traits may result in local adaptation at a fine geographic scale. Our results, in light of other previously published studies of <span class="hlt">admixture</span> in Canis, revealed a pattern of sex-biased hybridization, presumably generated by male wolves and dogs mating with female coyotes. This study is the most comprehensive genetic survey of <span class="hlt">admixture</span> in eastern coyotes and demonstrates that the frequency and scope of hybridization can be quantified with relatively few ancestry-informative markers. © 2013 John Wiley & Sons Ltd.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28787879','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28787879"><span>Effect of Gum Arabic karroo as a Water-Reducing <span class="hlt">Admixture</span> in Concrete.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mbugua, Rose; Salim, Ramadhan; Ndambuki, Julius</p> <p>2016-01-28</p> <p>Concrete is one of the most popular construction materials in the world. Chemical <span class="hlt">admixtures</span> are ingredients added to concrete to enhance its properties. However, most chemical <span class="hlt">admixtures</span> on the market today are expensive, thereby making them out of reach for small consumers of concrete. In Africa, use of chemical <span class="hlt">admixtures</span> is rare despite the harsh weather conditions. In the current study, Gum from Acacia karroo (GAK) was used as a water-reducing <span class="hlt">admixture</span> in concrete. A slump test, density and compressive strength were studied using different dosages of GAK while neat concrete was the control. Results showed that slump increased by 200% at a 2% dosage of GAK. This enabled reduction of water-to-binder (w/b) ratio from 0.61 to 0.48 for samples with a 3% dosage. Reduction in w/b resulted in increased compressive strength of 37.03% above the control after 180 days of curing for a 3% dosage. XRD studies also showed a decreased rate of hydration in the presence of GAK in concrete. It was concluded that GAK can be used in concrete as a water-reducing <span class="hlt">admixture</span>, which is environmentally-friendly, thus producing sustainable and greener concrete.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3929071','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3929071"><span>Mechanical Characteristics of Hardened Concrete with Different Mineral <span class="hlt">Admixtures</span>: A Review</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>The available literature identifies that the addition of mineral <span class="hlt">admixture</span> as partial replacement of cement improves the microstructure of the concrete (i.e., porosity and pore size distribution) as well as increasing the mechanical characteristics such as drying shrinkage and creep, compressive strength, tensile strength, flexural strength, and modulus of elasticity; however, no single document is available in which review and comparison of the influence of the addition of these mineral <span class="hlt">admixtures</span> on the mechanical characteristics of the hardened pozzolanic concretes are presented. In this paper, based on the reported results in the literature, mechanical characteristics of hardened concrete partially containing mineral <span class="hlt">admixtures</span> including fly ash (FA), silica fume (SF), ground granulated blast furnace slag (GGBS), metakaolin (MK), and rice husk ash (RHA) are discussed and it is concluded that the content and particle size of mineral <span class="hlt">admixture</span> are the parameters which significantly influence the mechanical properties of concrete. All mineral <span class="hlt">admixtures</span> enhance the mechanical properties of concrete except FA and GGBS which do not show a significant effect on the strength of concrete at 28 days; however, gain in strength at later ages is considerable. Moreover, the comparison of the mechanical characteristics of different pozzolanic concretes suggests that RHA and SF are competitive. PMID:24688443</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011JSR....66..447M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011JSR....66..447M"><span><span class="hlt">Entrainment</span> of cell division in phytoplankton with dynamic energy budgets</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Muller, Erik B.; Ananthasubramaniam, Bharath; Klanjšček, Tin; Nisbet, Roger M.</p> <p>2011-11-01</p> <p>We explore the <span class="hlt">entrainment</span> behavior of cell division in phytoplankton in the context of Dynamic Energy Budget (DEB) theory. In particular, we explore the range of DEB and environmental parameter values within which a cell divides at regular intervals in a periodic light environment with abundant nutrients and investigate the impact of parameter values on the phase of cell division. We consider three types of cells that differ in the evolution of surface area to volume ratio during the cell cycle: cells with a constant shape (isomorphs), cells with a constant surface area (V0-morphs) and cells with a constant surface area to volume ratio (V1-morphs), the latter being the default choice in studies on the population dynamics of unicellular organisms because of its desirable mathematical implications. Only in isomorphs and V0-morphs, however, cell division can be <span class="hlt">entrained</span> to a periodic light. Regular cell division in V1 is purely coincidental, as it depends on exact choices for parameter values. We attribute this to the fact that V1-morphs lack the negative feedback of size on the dynamics of reserves in V0-morphs and isomorphs. Because <span class="hlt">entrained</span> isomorphs and V0-morphs divide during the dark hours in our simulations, these two shapes can represent the division behavior of phytoplankton species that complete the cell cycle during the night, such as dinoflagellates and coccolithophores. A description of the division behavior of species completing the cell cycle during the day, such as silicon dependent diatoms and cyanobacteria, requires a more complex model than used in this paper. Furthermore, we explore the robustness of our findings by randomizing model parameters and introducing unevenness in biomass separation between daughter cells during cell division. We conclude that especially the <span class="hlt">entrainment</span> in V0-morphs is relatively insensitive to perturbations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3176892','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3176892"><span>Rhythmic TMS Causes Local <span class="hlt">Entrainment</span> of Natural Oscillatory Signatures</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Thut, Gregor; Veniero, Domenica; Romei, Vincenzo; Miniussi, Carlo; Schyns, Philippe; Gross, Joachim</p> <p>2011-01-01</p> <p>Summary Background Neuronal elements underlying perception, cognition, and action exhibit distinct oscillatory phenomena, measured in humans by electro- or magnetoencephalography (EEG/MEG). So far, the correlative or causal nature of the link between brain oscillations and functions has remained elusive. A compelling demonstration of causality would primarily generate oscillatory signatures that are known to correlate with particular cognitive functions and then assess the behavioral consequences. Here, we provide the first direct evidence for causal <span class="hlt">entrainment</span> of brain oscillations by transcranial magnetic stimulation (TMS) using concurrent EEG. Results We used rhythmic TMS bursts to directly interact with an MEG-identified parietal α-oscillator, activated by attention and linked to perception. With TMS bursts tuned to its preferred α-frequency (α-TMS), we confirmed the three main predictions of <span class="hlt">entrainment</span> of a natural oscillator: (1) that α-oscillations are induced during α-TMS (reproducing an oscillatory signature of the stimulated parietal cortex), (2) that there is progressive enhancement of this α-activity (synchronizing the targeted, α-generator to the α-TMS train), and (3) that this depends on the pre-TMS phase of the background α-rhythm (<span class="hlt">entrainment</span> of natural, ongoing α-oscillations). Control conditions testing different TMS burst profiles and TMS-EEG in a phantom head confirmed specificity of α-boosting to the case of synchronization between TMS train and neural oscillator. Conclusions The periodic electromagnetic force that is generated during rhythmic TMS can cause local <span class="hlt">entrainment</span> of natural brain oscillations, emulating oscillatory signatures activated by cognitive tasks. This reveals a new mechanism of online TMS action on brain activity and can account for frequency-specific behavioral TMS effects at the level of biologically relevant rhythms. PMID:21723129</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1005552','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1005552"><span>Mechanisms of Sediment <span class="hlt">Entrainment</span> and Transport in Rotorcraft Brownout</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2009-01-01</p> <p>equivalent wall shear, τw. For airborne wind- erosion studies (which have formed the basis for early brownout cloud simulations), a fully-turbulent...specific flow conditions. In the case of classic wind- erosion studies (which are now being used in brownout simulations–Refs. 4–7), an equilibrium fully...ABSTRACT Title of thesis: MECHANISMS OF SEDIMENT <span class="hlt">ENTRAINMENT</span> AND TRANSPORT IN ROTORCRAFT BROWNOUT Bradley Johnson, Master of Science, 2009 Thesis</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25729054','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25729054"><span>Persistence, <span class="hlt">entrainment</span>, and function of circadian rhythms in polar vertebrates.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Williams, Cory T; Barnes, Brian M; Buck, C Loren</p> <p>2015-03-01</p> <p>Polar organisms must cope with an environment that periodically lacks the strongest time-giver, or zeitgeber, of circadian organization-robust, cyclical oscillations between light and darkness. We review the factors influencing the persistence of circadian rhythms in polar vertebrates when the light-dark cycle is absent, the likely mechanisms of <span class="hlt">entrainment</span> that allow some polar vertebrates to remain synchronized with geophysical time, and the adaptive function of maintaining circadian rhythms in such environments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA586849','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA586849"><span>Modeling of Neutral <span class="hlt">Entrainment</span> in an FRC Thruster</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2012-07-01</p> <p>helium . The reaction rates as function of temperature are shown in Fig. 1 (left). Note that in addition to the electron impact ionization (denoted EII in...SCX N2 EII N2 recombination FIGURE 1. Different reaction rates in helium (left) and molecular nitrogen (right). The electron impact ionization rates...that the <span class="hlt">entrainment</span> process in a helium -based FRC thruster may be expected to be fairly efficient, especially for lower plasma temperatures. Note</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4084711','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4084711"><span>Rhythm as a Coordinating Device: <span class="hlt">Entrainment</span> With Disordered Speech</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Borrie, Stephanie A.; Liss, Julie M.</p> <p>2014-01-01</p> <p>Purpose The rhythmic <span class="hlt">entrainment</span> (coordination) of behavior during human interaction is a powerful phenomenon, considered essential for successful communication, supporting social and emotional connection, and facilitating sense-making and information exchange. Disruption in <span class="hlt">entrainment</span> likely occurs in conversations involving those with speech and language impairment, but its contribution to communication disorders has not been defined. As a first step to exploring this phenomenon in clinical populations, the present investigation examined the influence of disordered speech on the speech production properties of healthy interactants. Method Twenty-nine neurologically healthy interactants participated in a quasi-conversational paradigm, in which they read sentences (response) in response to hearing prerecorded sentences (exposure) from speakers with dysarthria (n = 4) and healthy controls (n = 4). Recordings of read sentences prior to the task were also collected (habitual). Results Findings revealed that interactants modified their speaking rate and pitch variation to align more closely with the disordered speech. Production shifts in these rhythmic properties, however, remained significantly different from corresponding properties in dysarthric speech. Conclusion <span class="hlt">Entrainment</span> offers a new avenue for exploring speech and language impairment, addressing a communication process not currently explained by existing frameworks. This article offers direction for advancing this line of inquiry. PMID:24686410</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21699907','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21699907"><span>Lack of eyeblink <span class="hlt">entrainments</span> in autism spectrum disorders.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nakano, Tamami; Kato, Nobumasa; Kitazawa, Shigeru</p> <p>2011-07-01</p> <p>Interpersonal synchrony is the temporal coordination of movements between individuals during social interactions. For example, it has been shown that listeners synchronize their eyeblinks to a speaker's eyeblinks, especially at breakpoints of speech, when viewing a close-up video clip of the speaker's face. We hypothesized that this interpersonal synchronous behavior would not be observed in individuals with autism spectrum disorders (ASD), which are characterized by impaired social communication. To test this hypothesis, we examined eyeblink <span class="hlt">entrainments</span> in adults with ASD. As we reported previously, the eyeblinks of adults without ASD were significantly synchronized with the speaker's eyeblinks at pauses in his speech when they viewed the speaker's entire face. However, the significant eyeblink synchronization disappeared when adults without ASD viewed only the speaker's eyes or mouth, suggesting that information from the whole face, including information from both the eyes and the mouth, was necessary for eyeblink <span class="hlt">entrainment</span>. By contrast, the ASD participants did not show any eyeblink synchronization with the speaker, even when viewing the speaker's eyes and mouth simultaneously. The lack of eyeblink <span class="hlt">entrainment</span> to the speaker in individuals with ASD suggests that they are not able to temporally attune themselves to others' behaviors. The deficits in temporal coordination may impair effective social communication with others.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21135157','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21135157"><span>CREB influences timing and <span class="hlt">entrainment</span> of the SCN circadian clock.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lee, Boyoung; Li, Aiqing; Hansen, Katelin F; Cao, Ruifeng; Yoon, Jae Hwa; Obrietan, Karl</p> <p>2010-12-01</p> <p>The transcriptional feedback circuit, which is at the core of the suprachiasmatic nucleus (SCN) circadian (i.e., 24 h) clock, is tightly coupled to both external <span class="hlt">entrainment</span> cues, such as light, as well as rhythmic cues that arise on a system-wide level within the SCN. One potential signaling pathway by which these cues are conveyed to the molecular clock is the CREB/CRE transcriptional cascade. In this study, we employed a tetracycline-inducible CREB repressor mouse strain, in which approximately 60% of the SCN neurons express the transgene, to test CREB functionality in the clock and its effects on overt rhythmicity. We show that attenuated CREB signaling in the SCN led to a significant reduction in light-evoked clock <span class="hlt">entrainment</span>. An examination of circadian timing revealed that CREB repressor mice exhibited normal free-running rhythms in the absence of external lighting cues. However, under conditions of constant light, which typically leads to a lengthening of the circadian period, CREB repressor mice exhibited a dramatic arrhythmic phenotype, which could be reversed with doxycycline. At a cellular level, the repression of CREB led to a significant reduction in both the expression of the circadian clock proteins PERIOD1 and PERIOD2 and the clock output hormones AVP and VIP. Together, these data support the idea that the CRE transcriptional pathway orchestrates transcriptional events that are essential for both the maintenance of SCN timing and light <span class="hlt">entrainment</span> of the circadian clock.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3597249','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3597249"><span><span class="hlt">Entrainment</span> of respiratory frequency to exercise rhythm during hypoxia.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Paterson, D J; Wood, G A; Marshall, R N; Morton, A R; Harrison, A B</p> <p>1987-05-01</p> <p>Breathing frequency (f) is often reported as having an integer-multiple relationship to limb movement (<span class="hlt">entrainment</span>) during rhythmic exercise. To investigate the strength of this coupling while running under hypoxic conditions, two male Caucasians and four male Nepalese porters were tested in the Annapurna region of the Himalayas at altitudes of 915, 2,135, 3,200, 4,420, and 5,030 m. In an additional study in a laboratory at sea level, three male and four female subjects inspired various O2-N2 mixtures [fraction of inspired O2 (FIO2) = 20.93, 17.39, 14.40, 11.81%] that were administered in a single-blind randomized fashion during a treadmill run (40% FIO2 maximum O2 consumption). Breathing and gait signals were stored on FM tape and later processed on a PDP 11/73 computer. The subharmonic relationships between these signals were determined from Fourier analysis (power spectrum), and the coincidence of coupling occurrence was statistically modeled. <span class="hlt">Entrainment</span> decreased linearly during increasing hypoxia (P less than 0.01). Moreover, a significant linear increase in f occurred during hypoxia (P less than 0.05), whereas stride frequency and metabolic rate remained constant, suggesting that hypoxic-induced increases in f decreased the degree of <span class="hlt">entrainment</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18247750','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18247750"><span><span class="hlt">Entrainment</span> and stimulated emission of ultrasonic piezoelectric auto-oscillators.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Weaver, Richard L; Lobkis, Oleg I; Yamilov, Alexey</p> <p>2007-12-01</p> <p>Theoretical modeling and laboratory tests are conducted for nonlinear auto-oscillating piezoelectric ultrasonic devices coupled to reverberant elastic bodies. The devices are shown to exhibit behavior familiar from the theory of coupled auto-oscillators. In particular, these spontaneously emitting devices adjust their limit-cycle frequency to the spectrum of the body. It is further shown that the auto-oscillations can be <span class="hlt">entrained</span> by an applied field; an incident wave at a frequency close to the frequency of the natural limit cycle <span class="hlt">entrains</span> the oscillator. Special attention is paid to the phase of <span class="hlt">entrainment</span>. Depending on details, the phase is such that the oscillator can be in a state of stimulated emission: the incident field amplifies the ultrasonic power emitted by the oscillator. These behaviors are essential to eventual design of an ultrasonic system that would consist of a number of such devices all synchronized to their mutual field, a system that would be an analog to a laser. A prototype uaser is constructed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFMEP33A0875K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFMEP33A0875K"><span>Particle <span class="hlt">entrainment</span> in dry and saturated granular flow experiments</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kaitna, R.; Maki, L.; Hill, K. M.</p> <p>2013-12-01</p> <p>Geophysical flows like rock avalanches and debris flows often gain volume and thereby destructive potential by <span class="hlt">entraining</span> loose sediment along the flow path. The mechanisms of sediment <span class="hlt">entrainment</span> are not yet well understood. The presence and amount of fluid in the bed and in the flow are expected to play a key role in the dynamics and erosion of grains. To gain insight of the role fluid plays in particle scale dynamics controlling particle <span class="hlt">entrainment</span> a small scale experimental facility has been developed at the University of Minnesota. Material with varying water content is released from a head gate and flows over a rigid bed followed by an erodible section. The water content in the erodible layer is adjustable and variations of fluid pressure are registered by pressure transducers at the base of the erodible as well as the non-erodible section. Other measured parameters include flow depth, velocity profile and net erosion or deposition. In this contribution we describe the effect of variations of inclination and fluid content on the bulk erosion/deposition behavior of simple mixtures of spherical glass beads and water. We compare dry granular flows over a dry bed, dry granular flows over a saturated bed, and saturated grain-fluid flows over a saturated bed. First results highlight the importance of slope angle on erosion efficiency. The presence of pore fluid in the bed shifts the transition between erosional and depositional flows to a lower flume inclination. Future experiments shall also include natural sediment mixtures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/22307957','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/22307957"><span><span class="hlt">Entrainment</span> of coarse grains using a discrete particle model</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Valyrakis, Manousos; Arnold, Roger B. Jr.</p> <p>2014-10-06</p> <p>Conventional bedload transport models and incipient motion theories relying on a time-averaged boundary shear stress are incapable of accounting for the effects of fluctuating near-bed velocity in turbulent flow and are therefore prone to significant errors. Impulse, the product of an instantaneous force magnitude and its duration, has been recently proposed as an appropriate criterion for quantifying the effects of flow turbulence in removing coarse grains from the bed surface. Here, a discrete particle model (DPM) is used to examine the effects of impulse, representing a single idealized turbulent event, on particle <span class="hlt">entrainment</span>. The results are classified according to the degree of grain movement into the following categories: motion prior to <span class="hlt">entrainment</span>, initial dislodgement, and energetic displacement. The results indicate that in all three cases the degree of particle motion depends on both the force magnitude and the duration of its application and suggest that the effects of turbulence must be adequately accounted for in order to develop a more accurate method of determining incipient motion. DPM is capable of simulating the dynamics of grain <span class="hlt">entrainment</span> and is an appropriate tool for further study of the fundamental mechanisms of sediment transport.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1261175','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1261175"><span>Stratocumulus Precipitation and <span class="hlt">Entrainment</span> Experiment (SPEE) Field Campaign Report</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Albrecht, Bruce; Ghate, Virendra; CADeddu, Maria</p> <p>2016-06-01</p> <p>The scientific focus of this project was to examine precipitation and <span class="hlt">entrainment</span> processes in marine stratocumulus clouds. The <span class="hlt">entrainment</span> studies focused on characterizing cloud turbulence at cloud top using Doppler cloud radar observations. The precipitation studies focused on characterizing the precipitation and the macroscopic properties (cloud thickness, and liquid water path) of the clouds. This project will contribute to the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s overall objective of providing the remote-sensing observations needed to improve the representation of key cloud processes in climate models. It will be of direct relevance to the components of ARM dealing with <span class="hlt">entrainment</span> and precipitation processes in stratiform clouds. Further, the radar observing techniques that will be used in this study were developed using ARM Southern Great Plains (SGP) facility observations under Atmospheric System Research (ASR) support. The observing systems operating automatously from a site located just north of the Center for Interdisciplinary Remotely-Piloted Aircraft Studies (CIRPAS) aircraft hangar in Marina, California during the period of 1 May to 4 November 2015 included: 1. Microwave radiometer: ARM Microwave Radiometer, 3-Channel (MWR3C) with channels centered at 23.834, 30, and 89 GHz; supported by Dr. Maria Cadeddu. 2. Cloud Radar: CIRPAS 95 GHz Frequency Modulated Continuous Wave (FMCW) Cloud Radar (Centroid Frequency Chirp Rate [CFCR]); operations overseen by Drs. Ghate and Albrecht. 3. Ceilometer: Vaisala CK-14; operations overseen by Drs. Ghate and Albrecht.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25170794','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25170794"><span>Neural <span class="hlt">entrainment</span> to the rhythmic structure of music.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tierney, Adam; Kraus, Nina</p> <p>2015-02-01</p> <p>The neural resonance theory of musical meter explains musical beat tracking as the result of <span class="hlt">entrainment</span> of neural oscillations to the beat frequency and its higher harmonics. This theory has gained empirical support from experiments using simple, abstract stimuli. However, to date there has been no empirical evidence for a role of neural <span class="hlt">entrainment</span> in the perception of the beat of ecologically valid music. Here we presented participants with a single pop song with a superimposed bassoon sound. This stimulus was either lined up with the beat of the music or shifted away from the beat by 25% of the average interbeat interval. Both conditions elicited a neural response at the beat frequency. However, although the on-the-beat condition elicited a clear response at the first harmonic of the beat, this frequency was absent in the neural response to the off-the-beat condition. These results support a role for neural <span class="hlt">entrainment</span> in tracking the metrical structure of real music and show that neural meter tracking can be disrupted by the presentation of contradictory rhythmic cues.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2590749','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2590749"><span>microRNA modulation of circadian clock period and <span class="hlt">entrainment</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cheng, Hai-Ying M.; Papp, Joseph W.; Varlamova, Olga; Dziema, Heather; Russell, Brandon; Curfman, John P.; Nakazawa, Takanobu; Shimizu, Kimiko; Okamura, Hitoshi; Impey, Soren; Obrietan, Karl</p> <p>2007-01-01</p> <p>microRNAs (miRNAs) are a class of small, non-coding, RNAs that regulate the stability or translation of mRNA transcripts. Although recent work has implicated miRNAs in development and in disease, the expression and function of miRNAs in the adult mammalian nervous system has not been extensively characterized. Here, we examine the role of two brain-specific miRNAs, miR-219 and miR-132, in modulating the circadian clock located in the suprachiasmatic nucleus. miR-219 is a target of the CLOCK/BMAL1 complex, exhibits robust circadian rhythms of expression and the in vivo knockdown of miR-219 lengthens the circadian period. miR-132 is induced by photic <span class="hlt">entrainment</span> cues via a MAPK/CREB-dependent mechanism, modulates clock gene expression, and attenuates the <span class="hlt">entraining</span> effects of light. Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and <span class="hlt">entrainment</span>. PMID:17553428</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3117189','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3117189"><span>Robust <span class="hlt">Entrainment</span> of Circadian Oscillators Requires Specific Phase Response Curves</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pfeuty, Benjamin; Thommen, Quentin; Lefranc, Marc</p> <p>2011-01-01</p> <p>The circadian clocks keeping time in many living organisms rely on self-sustained biochemical oscillations <span class="hlt">entrained</span> by external cues, such as light, to the 24-h cycle induced by Earth's rotation. However, environmental cues are unreliable due to the variability of habitats, weather conditions, or cue-sensing mechanisms among individuals. A tempting hypothesis is that circadian clocks have evolved so as to be robust to fluctuations in the signal that <span class="hlt">entrains</span> them. To support this hypothesis, we analyze the synchronization behavior of weakly and periodically forced oscillators in terms of their phase response curve (PRC), which measures phase changes induced by a perturbation applied at different times of the cycle. We establish a general relationship between the robustness of key <span class="hlt">entrainment</span> properties, such as stability and oscillator phase, on the one hand, and the shape of the PRC as characterized by a specific curvature or the existence of a dead zone, on the other hand. The criteria obtained are applied to computational models of circadian clocks and account for the disparate robustness properties of various forcing schemes. Finally, the analysis of PRCs measured experimentally in several organisms strongly suggests a case of convergent evolution toward an optimal strategy for maintaining a clock that is accurate and robust to environmental fluctuations. PMID:21641300</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25707274','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25707274"><span>Photic <span class="hlt">entrainment</span> in Drosophila assessed by locomotor activity recordings.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schlichting, Matthias; Helfrich-Förster, Charlotte</p> <p>2015-01-01</p> <p>Light is the most important Zeitgeber to <span class="hlt">entrain</span> the circadian clock of the fruit fly Drosophila melanogaster to the 24-h cycle on earth. The fruit fly's circadian clock is very light sensitive, mainly because about half of the 150 clock neurons in the fly's brain express the blue-light photopigment, Cryptochrome, which provokes an immediate degradation of the clock protein Timeless upon activation by light. Consequently, Drosophila's molecular clock can reset very fast to measure the changes in environmental-lighting conditions. However, usually the responses of the molecular clock to light are not directly measured, but conclusions about <span class="hlt">entrainment</span> of the circadian clock are drawn from recording the flies' locomotor activity rhythms. Here, we review how the flies' locomotor activity can be recorded under different light regimes and how <span class="hlt">entrainment</span> can be analyzed and properly judged. We also summarize the influence of different recording and lighting methods on the flies' activity pattern, highlight their advantages and disadvantages, and stress general pitfalls. © 2015 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016APS..DFDA35003F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016APS..DFDA35003F"><span>Fundamental <span class="hlt">Entrainment</span> Observations (VSL, etc.) for a SSSL</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Foss, John; Bade, Kyle; Neal, Douglas; Prevost, Richard</p> <p>2016-11-01</p> <p>Fundamental observations of the <span class="hlt">entrainment</span> process on the low speed side of a high Re self-preserving single stream shear layer have been made using PIV realizations. The Re value was: U0θmid / ν = 6.75*104, where θmid = 13.7 cm is the momentum thickness at the mid-location (x / θ (0) = 390) of the observations. The VSL (Viscous Super Layer), 15-20 ηK thick, is bounded by a well-defined border where the non-vortical/vortical transition occurs. The Kolmogorov microscale (ηK) was determined from the mean-square vorticity adjacent to the VSL. A threshold level to define the border (ωzθmid /U0 = 0.221) was selected by examination of the data. Quantitative measures of the <span class="hlt">entrainment</span> process have been obtained, including: i) the convoluted length of the border (Lb) made non-dimensional with respect to the length (Lm) of the temporally averaged flow field (Lb /Lm = 2.8) and ii) <vb2 > /ve2 = 17, as a measure of the sink-effect at the border. vb is the measured velocity at the border; ve is the well-established <span class="hlt">entrainment</span> velocity far from the active shear layer whose value: ve /U0 = 0.035, corresponds to the growth of the self-preserving SSSL (d θ / d x).</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22798027','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22798027"><span>Circadian <span class="hlt">entrainment</span> and its role in depression: a mechanistic review.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lall, G S; Atkinson, L A; Corlett, S A; Broadbridge, P J; Bonsall, D R</p> <p>2012-10-01</p> <p>The natural rotation of the earth generates an environmental day-night cycle that repeats every 24 h. This daily transition from dawn to dusk provides one of the most important time cues to which the majority of organisms synchronise their activity. Under these conditions, natural light, a photic stimulus, provides the principal <span class="hlt">entraining</span> cue. In mammals, an endogenous circadian pacemaker located within the suprachiasmatic nucleus (SCN) of the hypothalamus acts as a coordinating centre to align physiological activity with the environmental light-dark cycle. However, the SCN also receives regulatory input from a number of behavioural, non-photic, cues such as physical activity, social interactions and feeding routines. The unique ability of the SCN to integrate both photic and non-photic cues allows it to generate a rhythm that is tailored to the individual and <span class="hlt">entrained</span> to the environment. Here, we review the key neurotransmitter systems involved in both photic and non-photic transmission to the SCN and their interactions that assist in generating an <span class="hlt">entrained</span> output rhythm. We also consider the impact on health of a desynchronised circadian system with a focus on depressive affective disorders and current therapies aimed at manipulating the relationship between photic and non-photic SCN regulators.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA248315','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA248315"><span>An Experimental Study of Plunging Liquid Jet Induced <span class="hlt">Air</span> Carryunder and Dispersion</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1992-03-31</p> <p>Plunging Liquid Jet - The <span class="hlt">Air</span> <span class="hlt">Entrainment</span> Process". It is intended that this paper will be finalized and...the fifth quarterly report for ONR grant N00014-91-J-1271, "An Experimental Study of Plunging Liquid Jet Induced <span class="hlt">Air</span> Carryunder and Dispersion" (Lahey...Drew - CoPI). rhis report period has been concerned with performing an analysis of the <span class="hlt">air</span> <span class="hlt">entrainment</span> process associated with a plunging liquid</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20646980','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20646980"><span>Spatial assessment of Argentinean genetic <span class="hlt">admixture</span> with geographical information systems.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Diaz-Lacava, Amalia; Walier, Maja; Penacino, Gustavo; Wienker, Thomas F; Baur, Max P</p> <p>2011-08-01</p> <p>In recent years there has been much attention to Argentinean population stratification. We were interested in assessing population stratification from a geographical perspective and summarizing it in form of maps. We mapped the genetic <span class="hlt">admixture</span> of the extant male population in central and northern Argentina on the basis of forensic Y-chromosomal haplotypes. We addressed the question which group of genetically similar individuals is predominant in this area. Haplotypes containing seven Y-chromosomal short tandem repeat polymorphisms (Y-STRs), also known as microsatellites - DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393 - were constructed for 145 individuals, recruited in 10 provinces. 97 distinct haplotypes were clustered into four clusters according to molecular distances. A genetic geostatistical analysis was conducted with the open-source geographical information system GRASS GIS. For each haplotype cluster, the according frequency was spatially interpolated over the total study area. Juxtaposing the interpolation surfaces, we screened point-wisely the maximal frequency as well as the label of the respective cluster. The screening results were combined in one summary map. We repeated this procedure for the second maximal frequencies. The resulting maps subdivide the study area into continuous regions comprising one predominant group of similar haplotypes. The first summary map divides the study area into three regions and the second summary map divides the area into four regions. The results of our analysis indicate that two groups of similar European haplotypes alternatively dominate the largest extension of the Argentinean territory. A third group, including South-American haplotypes, dominates the indigenous northwestern Argentinean area. The last group, including worldwide dispersed haplotypes, preponderates in frequency in second place in central Argentina. Our findings confirm a widespread European paternal ancestry, a substantial Amerindian</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4940511','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4940511"><span>Genetic <span class="hlt">admixture</span> and lineage separation in a southern Andean plant</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Morello, Santiago; Sede, Silvana M.</p> <p>2016-01-01</p> <p> varieties of E. alpina: var. alpina is more closely related to E. rubra and other species than to its own counterpart E. alpina var. carmelitana. Geometric morphometrics analysis (Elliptic Fourier descriptors) revealed significant differences in leaf shape between varieties. We found that diversity in Escallonia species analyzed here is geographically structured and deep divergence between varieties of E. alpina could be associated to ancient evolutionary events like orogeny. <span class="hlt">Admixture</span> in southern populations could be the result of hybridization at the margins of the parental species’ distribution range. PMID:27179539</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFM.V23C2833D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFM.V23C2833D"><span>Flow Transformation in Pyroclastic Density Currents: <span class="hlt">Entrainment</span> and Granular Dynamics during the 2006 eruption of Tungurahua</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Dufek, J.; Benage, M. C.; Geist, D.; Harpp, K. S.</p> <p>2013-12-01</p> <p> have conducted high resolution simulations in concert with detailed measurements of these flows from both up flow and down flow from the transformation to document the process of dense to dilute flow transition. The field characterization includes mapping of the flows, grain size analysis, documenting flow direction indicators, comminution rounding, thermal proxies for <span class="hlt">air</span> <span class="hlt">entrainment</span>, and bed form documentation. We used a three-dimensional, multiphase (Eulerian-Eulerian-Lagrangian, EEL) modeling approach to describe size sorting, concentration gradients, and stresses in these evolving flows using the topography of the near Chambo River crossing (Dufek and Bergantz, 2007a; Dufek and Bertgantz, 2007b). The numerical models reveal extensive <span class="hlt">entrainment</span> in the surge-generating phase of the flow, and secondary plume generation as fine ash in transported by hot gases higher into the atmosphere. Granular waves develop in the confined channels of the dense flow resulting bed shear stress perturbations. These granular instabilities and <span class="hlt">entrainment</span> result in pulsing conditions in the surge, accounting for much of the unsteady behavior that results in fluctuations in grain size and bed form in the surge deposits.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFM.V52C..07R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFM.V52C..07R"><span><span class="hlt">Entrainment</span> of granular substrate by pyroclastic flows: an experimental study and its implications for flow dynamics</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Roche, O.; Niño, Y.; Mangeney, A.; Brand, B. D.; Valentine, G. A.</p> <p>2012-12-01</p> <p>Pyroclastic flows deposits may contain lithics <span class="hlt">entrained</span> from an unconsolidated granular substrate on which the flows emplaced. In order to address this issue, analog experiments on dense gas-particle flows propagating on a horizontal granular layer were carried out to elucidate the <span class="hlt">entrainment</span> mechanisms and to infer the dynamics of pyroclastic flows. The experimental flows were generated from the release of gas-fluidized columns of fine (80 μm) particles in a horizontal channel whose base was made of an unconsolidated granular layer. The flows consisted of a fluidized <span class="hlt">air</span>-particles mixture, and the small hydraulic permeability of the material allowed for long-lived high interstitial pore fluid pressure during emplacement. Basal pore pressure measurements in preliminary experiments involving a rigid substrate revealed that the sliding head of the flows generated a dynamic underpressure (relative to atmosphere) proportional to the square of the front velocity. As such underpressure at the flow base was likely to promote an upward pressure gradient that could cause uplift of particles of a granular substrate, we did a theoretical analysis in order to determine the critical underpressure and the corresponding flow velocity (Uc) at which uplift could occur. This analysis showed that Uc~(dρpg/Cρ)1/2 for spherical particles, where d and ρp are the particle diameter and density, respectively, C is an empirical constant, and is ρ is the bulk flow density. It was validated with experiments on flows propagating on 3 cm-thick substrates of steel beads of diameter d=1.6 mm. The beads were first dragged horizontally individually due to basal shear, and onset of uplift did occur at Uc~0.9 m/s. The beads uplifted were incorporated within the flow base, to a height that increased up to 6-8 mm at flow velocities up to 2.5-3 m/s, and were <span class="hlt">entrained</span> over distances of several tens of cm representing a significant part of the flow runout. The flow deposits hence had a well</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..14.3526F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..14.3526F"><span>Landslide boost from <span class="hlt">entrainment</span> of erodible material along the slope</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Farin, M.; Mangeney, A.; Roche, O.; Ionescu, I. R.; Hungr, O.</p> <p>2012-04-01</p> <p>Landslides, debris flows, pyroclastic flows and avalanches are natural hazards that threaten life and property in mountainous, volcanic, coastal and seismically-active areas. The granular mass tends to accelerate as gravity pulls it down the slope and will decelerate on more gentle slopes, where frictional forces that dissipate energy can overcome the driving forces. The <span class="hlt">entrainment</span> of underlying sediments or debris into the gravitational granular flows is suspected to be critical to their dynamics, but direct measurement of material <span class="hlt">entrainment</span> in natural flows is very difficult. Nevertheless, qualitative and quantitative field observations suggest that material <span class="hlt">entrainment</span> can either increase or decrease flow velocity and deposit extent, depending on the geological setting and the type of gravitational flow. We present laboratory experiments of granular column collapse over an inclined plane covered by an erodible bed, designed to mimic erosion processes of natural flows traveling over deposits built up by earlier events. The controlling parameters are the inclination of the plane, the aspect ratio of the granular column released and the thickness of the erodible layer. The avalanche excavates the erodible layer immediately at the flow front, behind which waves traveling downstream help removing grains from the erodible bed are observed. We show that erosion processes increases the flow mobility (i. e. runout) by up to 25% over slopes with inclination close to the repose angle of the grains. Erosion efficiency is shown to strongly depend on the slope and on the nature of the erodible bed (i. e. degree of compaction): erosion effects are smaller as the compaction of the erodible granular bed increases. The excavation depth first increases and stabilizes to a critical value, and finally decreases when increasing the thickness of the erodible bed. We demonstrate that the increase of mass of the flowing grains caused by <span class="hlt">entrainment</span> of the erodible layer is not enough</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AIPC.1800b0004I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AIPC.1800b0004I"><span>Research on curing behavior of concrete with anti-frost <span class="hlt">admixtures</span> at subzero temperature</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ionov, Yulian; Kramar, Ludmila; Kirsanova, Alena; Kolegova, Irina</p> <p>2017-01-01</p> <p>The purpose of this paper is research on curing behavior of cold-weather concrete with anti-frost <span class="hlt">admixtures</span>. During the study derivative thermal and X-ray phase analyses were performed and tests were carried out according to the standard GOST technique. The research results obtained reveal the peculiarities of cement hydration and concrete curing at subzero temperatures. The influence of subzero temperatures and anti-frost <span class="hlt">admixtures</span> on hydrated phases of hardened cement paste and concrete strength formation was studied. It is found that cold-weather concrete does not cure at subzero temperatures, but when defrosting it attains 80 to 85% of its grade strength by the 28th day. Concrete achieves its grade strength when curing in normal conditions in 60 days only. Freezing concrete with anti-frost <span class="hlt">admixtures</span> results in increase of calcium hydroxide content in hardened cement paste immediately when produced and has increased tendency of concrete to carbonation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28269933','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28269933"><span>PREMIX: PRivacy-preserving EstiMation of Individual <span class="hlt">admiXture</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Feng; Dow, Michelle; Ding, Sijie; Lu, Yao; Jiang, Xiaoqian; Tang, Hua; Wang, Shuang</p> <p>2016-01-01</p> <p>In this paper we proposed a framework: PRivacy-preserving EstiMation of Individual <span class="hlt">admiXture</span> (PREMIX) using Intel software guard extensions (SGX). SGX is a suite of software and hardware architectures to enable efficient and secure computation over confidential data. PREMIX enables multiple sites to securely collaborate on estimating individual <span class="hlt">admixture</span> within a secure enclave inside Intel SGX. We implemented a feature selection module to identify most discriminative Single Nucleotide Polymorphism (SNP) based on informativeness and an Expectation Maximization (EM)-based Maximum Likelihood estimator to identify the individual <span class="hlt">admixture</span>. Experimental results based on both simulation and 1000 genome data demonstrated the efficiency and accuracy of the proposed framework. PREMIX ensures a high level of security as all operations on sensitive genomic data are conducted within a secure enclave using SGX.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5356474','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5356474"><span>Complex <span class="hlt">Admixture</span> Preceded and Followed the Extinction of Wisent in the Wild</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hartmann, Stefanie; Paijmans, Johanna L. A.; Taron, Ulrike; Xenikoudakis, Georgios; Cahill, James A.; Heintzman, Peter D.; Shapiro, Beth; Baryshnikov, Gennady; Bunevich, Aleksei N.; Crees, Jennifer J.; Dobosz, Roland; Manaserian, Ninna; Okarma, Henryk; Tokarska, Małgorzata; Turvey, Samuel T.; Wójcik, Jan M.; Żyła, Waldemar; Szymura, Jacek M.; Hofreiter, Michael</p> <p>2017-01-01</p> <p>Retracing complex population processes that precede extreme bottlenecks may be impossible using data from living individuals. The wisent (Bison bonasus), Europe’s largest terrestrial mammal, exemplifies such a population history, having gone extinct in the wild but subsequently restored by captive breeding efforts. Using low coverage genomic data from modern and historical individuals, we investigate population processes occurring before and after this extinction. Analysis of aligned genomes supports the division of wisent into two previously recognized subspecies, but almost half of the genomic alignment contradicts this population history as a result of incomplete lineage sorting and <span class="hlt">admixture</span>. <span class="hlt">Admixture</span> between subspecies populations occurred prior to extinction and subsequently during the captive breeding program. <span class="hlt">Admixture</span> with the Bos cattle lineage is also widespread but results from ancient events rather than recent hybridization with domestics. Our study demonstrates the huge potential of historical genomes for both studying evolutionary histories and for guiding conservation strategies. PMID:28007976</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5333197','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5333197"><span>PREMIX: PRivacy-preserving EstiMation of Individual <span class="hlt">admiXture</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chen, Feng; Dow, Michelle; Ding, Sijie; Lu, Yao; Jiang, Xiaoqian; Tang, Hua; Wang, Shuang</p> <p>2016-01-01</p> <p>In this paper we proposed a framework: PRivacy-preserving EstiMation of Individual <span class="hlt">admiXture</span> (PREMIX) using Intel software guard extensions (SGX). SGX is a suite of software and hardware architectures to enable efficient and secure computation over confidential data. PREMIX enables multiple sites to securely collaborate on estimating individual <span class="hlt">admixture</span> within a secure enclave inside Intel SGX. We implemented a feature selection module to identify most discriminative Single Nucleotide Polymorphism (SNP) based on informativeness and an Expectation Maximization (EM)-based Maximum Likelihood estimator to identify the individual <span class="hlt">admixture</span>. Experimental results based on both simulation and 1000 genome data demonstrated the efficiency and accuracy of the proposed framework. PREMIX ensures a high level of security as all operations on sensitive genomic data are conducted within a secure enclave using SGX. PMID:28269933</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10803666','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10803666"><span>Population evolution in 20th-century Easter Island: endogamy and <span class="hlt">admixture</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hernández, M; García-Moro, C; Moral, P; González-Martín, A</p> <p>2000-04-01</p> <p>We studied the 20th-century evolution of the Rapanui population of Easter Island, the most geographically isolated in the world, to analyze the current process of <span class="hlt">admixture</span>. Using parochial birth records, we determined origin of the birth parents based on their surnames. The origin of parents reveals two stages of population evolution: endogamy, due to the isolation of the island, but with a strong rejection of isonymous marriages; and <span class="hlt">admixture</span>, beginning in 1965 with the opening of the island to the rest of the world. We used Lasker's coefficient (Lasker's Ri) and the Shannon-Weaver coefficient of diversity (H) to characterize both stages. The gene flow evaluated from <span class="hlt">admixture</span> has increased significantly since 1965. Births from exogamous unions represented 3.5% of total births from 1937 to 1965. increased to 43.2% between 1966 and 1980, and constituted 50.8% of all births between 1981 and 1996.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010LNCS.6044...31B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010LNCS.6044...31B"><span><span class="hlt">Admixture</span> Aberration Analysis: Application to Mapping in Admixed Population Using Pooled DNA</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bercovici, Sivan; Geiger, Dan</p> <p></p> <p><span class="hlt">Admixture</span> mapping is a gene mapping approach used for the identification of genomic regions harboring disease susceptibility genes in the case of recently admixed populations such as African Americans. We present a novel method for <span class="hlt">admixture</span> mapping, called <span class="hlt">admixture</span> aberration analysis (AAA), that uses a DNA pool of affected admixed individuals. We demonstrate through simulations that AAA is a powerful and economical mapping method under a range of scenarios, capturing complex human diseases such as hypertension and end stage kidney disease. The method has a low false-positive rate and is robust to deviation from model assumptions. Finally, we apply AAA on 600 prostate cancer-affected African Americans, replicating a known risk locus. Simulation results indicate that the method can yield over 96% reduction in genotyping. Our method is implemented as a Java program called AAAmap and is freely available.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AGUFM.A53B..08G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AGUFM.A53B..08G"><span><span class="hlt">Entrainment</span> and Microphysics in DYCOMS-II Stratocumulus</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gerber, H. E.; Frick, G.; Malinowski, S.; Burnet, F.; Brenguier, J.</p> <p>2005-12-01</p> <p>During the nine DYCOMS-II flights through stratocumulus (Sc) off the California Coast with the NCAR C-130 research aircraft measurements of thermodynamics and microphysics were made with unprecedented resolution by three co-located probes. The UFT (ultra-fast temperature probe; U. of Warsaw) and the PVM (LWC and effective radius; Gerber Scientific) measured incloud with a resolution of 10 cm, and the FFSSP (fast FSSP; Meteo-France) measured with a resolution of 2 m. Our measurements and their analyses have led to an improved understanding of the physical processes associated with <span class="hlt">entrainment</span> and its affect on Sc microphysics. We describe our results including the following: Cloud-top interacts with the warm and dry free atmosphere above the Sc to create the EIL (<span class="hlt">entrainment</span> interface layer) several tens of m thick on the average. Further cloud detrains and mixes with the EIL to generate cloud-free moisture and temperature conditions ranging between cloud-top and free-atmosphere conditions. Buoyancy sorting occurs in the EIL with some parcels approaching the buoyancy at cloud-top. At that point these parcels enter cloud in a near thermodynamically-neutral fashion as shown by comparing UFT measurements in <span class="hlt">entrainment</span> features ("cloud holes") with unaffected adjacent cloud, and in a mixing manner that resembles inhomogeneous mixing by diluting droplet number but not reducing their size as shown by the PVM and the FFSSP. This behavior occurs despite nearly all the Sc showing strong CTEI (cloud-top <span class="hlt">entrainment</span> instability). Thus cooling due to the evaporation of cloud water contributes a negligible amount to buoyancy production at cloud top, it simply contributes a small amount to conditioning the EIL. Further, supersaturation transients caused by mixing of saturated parcels at different temperature near cloud top are not present. We find that the holes with LWC reduced by <span class="hlt">entrainment</span> and embedded in down-welling regions caused by radiative cooling can reach their SEL</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23284287','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23284287"><span>Population Genomics of sub-saharan Drosophila melanogaster: African diversity and non-African <span class="hlt">admixture</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pool, John E; Corbett-Detig, Russell B; Sugino, Ryuichi P; Stevens, Kristian A; Cardeno, Charis M; Crepeau, Marc W; Duchen, Pablo; Emerson, J J; Saelao, Perot; Begun, David J; Langley, Charles H</p> <p>2012-01-01</p> <p>Drosophila melanogaster has played a pivotal role in the development of modern population genetics. However, many basic questions regarding the demographic and adaptive history of this species remain unresolved. We report the genome sequencing of 139 wild-derived strains of D. melanogaster, representing 22 population samples from the sub-Saharan ancestral range of this species, along with one European population. Most genomes were sequenced above 25X depth from haploid embryos. Results indicated a pervasive influence of non-African <span class="hlt">admixture</span> in many African populations, motivating the development and application of a novel <span class="hlt">admixture</span> detection method. <span class="hlt">Admixture</span> proportions varied among populations, with greater <span class="hlt">admixture</span> in urban locations. <span class="hlt">Admixture</span> levels also varied across the genome, with localized peaks and valleys suggestive of a non-neutral introgression process. Genomes from the same location differed starkly in ancestry, suggesting that isolation mechanisms may exist within African populations. After removing putatively admixed genomic segments, the greatest genetic diversity was observed in southern Africa (e.g. Zambia), while diversity in other populations was largely consistent with a geographic expansion from this potentially ancestral region. The European population showed different levels of diversity reduction on each chromosome arm, and some African populations displayed chromosome arm-specific diversity reductions. Inversions in the European sample were associated with strong elevations in diversity across chromosome arms. Genomic scans were conducted to identify loci that may represent targets of positive selection within an African population, between African populations, and between European and African populations. A disproportionate number of candidate selective sweep regions were located near genes with varied roles in gene regulation. Outliers for Europe-Africa F(ST) were found to be enriched in genomic regions of locally elevated</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23969873','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23969873"><span>Chemical stability of <span class="hlt">admixtures</span> combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shields, David E; Aclan, Jennifer; Szatkowski, Aaron</p> <p>2008-01-01</p> <p>Although the U.S. Food and Drug Administration has not approved the combined use of intrathecal medications, practitioners frequently prescribe combination intrathecal therapy for patients who do not experience adequate analgesia with a single intrathecal agent; however, the chemical stability of an analgesic combination may influence the frequency of pump refills necessary to maintain safe and efective pain control. This investigation was performed to evaluate the chemical stability of <span class="hlt">admixtures</span> containing 25 mcg/mL ziconotide and either 1000 mcg/mL fentanyl citrate or 1000 mcg/mL sufentanil citrate during simulated intrathecal infusion under laboratory conditions at 37 deg C. <span class="hlt">Admixtures</span> were prepared from commercial ziconotide (25 mcg/mL) and lyophilized powders of the opioid drugs, sparged with nitrogen to remove dissolved oxygen, and stored in implantable intrathecal pumps at 37 deg C. Samples obtained at various intervals over the course of 40 days were assessed for drug concentrations by using high-performance liquid chromatography. The periods of time that the <span class="hlt">admixtures</span> retained > or = 90% and > or = 80% of the initial concentrations of each drug (i.e., the 90% and 80% stabilities) were determined by using linear regression and 95% confidence intervals. At study end, ziconotide concentrations averaged 87.5% of the initial concentration in the ziconotide/fentanyl <span class="hlt">admixture</span> and 89.3% of the initial concentration in the ziconotide/sufentanil <span class="hlt">admixture</span>; opioid concentrations were unchanged. Ziconotide was 90% stable for 26 days and 80% stable for 58 days (extrapolated) when combined with fentanyl; when combined with sufentanil, ziconotide was 90% stable for 33 days and 80% stable for 68 days (extrapolated). The opioids were stable throughout the study. At the concentrations used in this study, ziconotide/fentanyl and ziconotide/sufentanil <span class="hlt">admixtures</span> were relatively stable.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12545274','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12545274"><span>Relation of risk of systemic lupus erythematosus to west African <span class="hlt">admixture</span> in a Caribbean population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Molokhia, M; Hoggart, C; Patrick, A L; Shriver, M; Parra, E; Ye, J; Silman, A J; McKeigue, P M</p> <p>2003-03-01</p> <p>Risk of systemic lupus erythematosus (SLE) is higher in people of west African descent than in Europeans. The objective of this study was to distinguish between genetic and environmental explanations for this ethnic difference by examining the relationship of disease risk to individual <span class="hlt">admixture</span> (defined as the proportion of the genome that is of west African ancestry); 124 cases of SLE and 219 matched controls resident in Trinidad were studied. Analysis of <span class="hlt">admixture</span> was restricted to 52 cases and 107 controls who reported no Indian or Chinese ancestry. These individuals were typed with a panel of 26 single-nucleotide polymorphisms and five insertion/deletion polymorphisms chosen to have large allele frequency differentials between west African, European and Native American populations. A Bayesian model for population <span class="hlt">admixture</span>, individual <span class="hlt">admixture</span> and locus ancestry was fitted by Markov chain simulation. Mean west African <span class="hlt">admixture</span> (M) was 0.81 in cases and 0.74 in controls (P=0.01). The risk ratio for SLE associated with unit change in M was estimated as 32.5 with a 95% confidence interval (CI) of 2.0-518. Adjustment for measures of socioeconomic status (household amenities in childhood and years of education) altered this risk ratio only slightly (adjusted risk ratio: 28.4, 95% CI 1.7-485). These results support an additive genetic model for the ethnic difference in risk of SLE between west Africans and Europeans, rather than an environmental explanation or an "overdominant" model in which risk is higher in heterozygous than in homozygous individuals. This conclusion lays a basis for localizing the genes underlying this ethnic difference in risk of SLE by <span class="hlt">admixture</span> mapping.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3837693','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3837693"><span>African and Non-African <span class="hlt">Admixture</span> Components in African Americans and An African Caribbean Population</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Murray, Tanda; Beaty, Terri H.; Mathias, Rasika A.; Rafaels, Nicholas; Grant, Audrey Virginia; Faruque, Mezbah U.; Watson, Harold R.; Ruczinski, Ingo; Dunston, Georgia M.; Barnes, Kathleen C.</p> <p>2013-01-01</p> <p><span class="hlt">Admixture</span> is a potential source of confounding in genetic association studies, so it becomes important to detect and estimate <span class="hlt">admixture</span> in a sample of unrelated individuals. Populations of African descent in the US and the Caribbean share similar historical backgrounds but the distributions of African <span class="hlt">admixture</span> may differ. We selected 416 ancestry informative markers (AIMs) to estimate and compare <span class="hlt">admixture</span> proportions using STRUCTURE in 906 unrelated African Americans (AAs) and 294 Barbadians (ACs) from a study of asthma. This analysis showed AAs on average were 72.5% African, 19.6% European and 8% Asian, while ACs were 77.4% African, 15.9% European, and 6.7% Asian which were significantly different. A principal components analysis based on these AIMs yielded one primary eigenvector that explained 54.04% of the variation and captured a gradient from West African to European <span class="hlt">admixture</span>. This principal component was highly correlated with African vs. European ancestry as estimated by STRUCTURE (r2 = 0.992, r2 = 0.912, respectively). To investigate other African contributions to African American and Barbadian <span class="hlt">admixture</span>, we performed PCA on ~14,000 (14k) genome-wide SNPs in AAs, ACs, Yorubans, Luhya and Maasai African groups, and estimated genetic distances (FST). We found AAs and ACs were closest genetically (FST = 0.008), and both were closer to the Yorubans than the other East African populations. In our sample of individuals of African descent, ~400 well-defined AIMs were just as good for detecting substructure as ~14,000 random SNPs drawn from a genome-wide panel of markers. PMID:20717976</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20717976','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20717976"><span>African and non-African <span class="hlt">admixture</span> components in African Americans and an African Caribbean population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Murray, Tanda; Beaty, Terri H; Mathias, Rasika A; Rafaels, Nicholas; Grant, Audrey Virginia; Faruque, Mezbah U; Watson, Harold R; Ruczinski, Ingo; Dunston, Georgia M; Barnes, Kathleen C</p> <p>2010-09-01</p> <p><span class="hlt">Admixture</span> is a potential source of confounding in genetic association studies, so it becomes important to detect and estimate <span class="hlt">admixture</span> in a sample of unrelated individuals. Populations of African descent in the US and the Caribbean share similar historical backgrounds but the distributions of African <span class="hlt">admixture</span> may differ. We selected 416 ancestry informative markers (AIMs) to estimate and compare <span class="hlt">admixture</span> proportions using STRUCTURE in 906 unrelated African Americans (AAs) and 294 Barbadians (ACs) from a study of asthma. This analysis showed AAs on average were 72.5% African, 19.6% European and 8% Asian, while ACs were 77.4% African, 15.9% European, and 6.7% Asian which were significantly different. A principal components analysis based on these AIMs yielded one primary eigenvector that explained 54.04% of the variation and captured a gradient from West African to European <span class="hlt">admixture</span>. This principal component was highly correlated with African vs. European ancestry as estimated by STRUCTURE (r(2)=0.992, r(2)=0.912, respectively). To investigate other African contributions to African American and Barbadian <span class="hlt">admixture</span>, we performed PCA on approximately 14,000 (14k) genome-wide SNPs in AAs, ACs, Yorubans, Luhya and Maasai African groups, and estimated genetic distances (F(ST)). We found AAs and ACs were closest genetically (F(ST)=0.008), and both were closer to the Yorubans than the other East African populations. In our sample of individuals of African descent, approximately 400 well-defined AIMs were just as good for detecting substructure as approximately 14,000 random SNPs drawn from a genome-wide panel of markers. (c) 2010 Wiley-Liss, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/20871543','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/20871543"><span>Effects of drying conditions, <span class="hlt">admixtures</span> and specimen size on shrinkage strains</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Al-Saleh, Saleh A. . E-mail: alsaleh@dr.com; Al-Zaid, Rajeh Z.</p> <p>2006-10-15</p> <p>The paper presents the results of an experimental investigation on the effects of drying conditions, specimen size and presence of plasticizing <span class="hlt">admixture</span> on the development of shrinkage strains. The measurements are taken in a harsh (50 deg. C and 5% R.H.) and a moderate environment (28 deg. C and 50% R.H.). The results include strain development at various levels of cross sections of concrete prisms. The drying conditions are found to be the dominant parameter affecting the shrinkage strain development particularly in specimens of smaller sizes. The effect of plasticizing <span class="hlt">admixture</span> on shrinkage strains is negligible.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFM.V41B2797P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFM.V41B2797P"><span>Experimental and theoretical study of <span class="hlt">entrainment</span> in volcanic line plumes produced by fissure eruptions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Paillat, S.; Kaminski, E. C.</p> <p>2013-12-01</p> <p>Basaltic fissure eruptions can produce turbulent line plumes injecting gas and particles in the atmosphere. The dynamic of these line plumes is controlled by the efficiency of <span class="hlt">entrainment</span> as quantified by the so-called <span class="hlt">entrainment</span> coefficient α. There are only scarce experimental constraints on α in planar jets and plumes. Whereas a constant value of the <span class="hlt">entrainment</span> coefficient is used in models, data from the