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Sample records for air floatation daf

  1. Inverse Floatation

    NASA Astrophysics Data System (ADS)

    Nath, Saurabh; Mukherjee, Anish; Chatterjee, Souvick; Ganguly, Ranjan; Sen, Swarnendu; Mukhopadhyay, Achintya; Boreyko, Jonathan

    2014-11-01

    We have observed that capillarity forces may cause floatation in a few non-intuitive configurations. These may be divided into 2 categories: i) floatation of heavier liquid droplets on lighter immiscible ones and ii) fully submerged floatation of lighter liquid droplets in a heavier immiscible medium. We call these counter-intuitive because of the inverse floatation configuration. For case (i) we have identified and studied in detail the several factors affecting the shape and maximum volume of the floating drop. We used water and vegetable oil combinations as test fluids and established the relation between Bond Number and maximum volume contained in a floating drop (in the order of μL). For case (ii), we injected vegetable oil drop-wise into a pool of water. The fully submerged configuration of the drop is not stable and a slight perturbation to the system causes the droplet to burst and float in partially submerged condition. Temporal variation of a characteristic length of the droplet is analyzed using MATLAB image processing. The constraint of small Bond Number establishes the assumption of lubrication regime in the thin gap. A brief theoretical formulation also shows the temporal variation of the gap thickness. Jadavpur University, Jagadis Bose Centre of Excellence, Virginia Tech.

  2. Critical evaluation and modeling of algal harvesting using dissolved air flotation. DAF Algal Harvesting Modeling

    SciTech Connect

    Zhang, Xuezhi; Hewson, John C.; Amendola, Pasquale; Reynoso, Monica; Sommerfeld, Milton; Chen, Yongsheng; Hu, Qiang

    2014-07-14

    In our study, Chlorella zofingiensis harvesting by dissolved air flotation (DAF) was critically evaluated with regard to algal concentration, culture conditions, type and dosage of coagulants, and recycle ratio. Harvesting efficiency increased with coagulant dosage and leveled off at 81%, 86%, 91%, and 87% when chitosan, Al3+, Fe3+, and cetyl trimethylammonium bromide (CTAB) were used at dosages of 70, 180, 250, and 500 mg g-1, respectively. The DAF efficiency-coagulant dosage relationship changed with algal culture conditions. In evaluating the influence of the initial algal concentration and recycle ratio revealed that, under conditions typical for algal harvesting, we found that it is possible that the number of bubbles is insufficient. A DAF algal harvesting model was developed to explain this observation by introducing mass-based floc size distributions and a bubble limitation into the white water blanket model. Moreover, the model revealed the importance of coagulation to increase floc-bubble collision and attachment, and the preferential interaction of bubbles with larger flocs, which limited the availability of bubbles to the smaller sized flocs. The harvesting efficiencies predicted by the model agree reasonably with experimental data obtained at different Al3+ dosages, algal concentrations, and recycle ratios. Based on this modeling, critical parameters for efficient algal harvesting were identified.

  3. Critical evaluation and modeling of algal harvesting using dissolved air flotation. DAF Algal Harvesting Modeling

    DOE PAGES

    Zhang, Xuezhi; Hewson, John C.; Amendola, Pasquale; ...

    2014-07-14

    In our study, Chlorella zofingiensis harvesting by dissolved air flotation (DAF) was critically evaluated with regard to algal concentration, culture conditions, type and dosage of coagulants, and recycle ratio. Harvesting efficiency increased with coagulant dosage and leveled off at 81%, 86%, 91%, and 87% when chitosan, Al3+, Fe3+, and cetyl trimethylammonium bromide (CTAB) were used at dosages of 70, 180, 250, and 500 mg g-1, respectively. The DAF efficiency-coagulant dosage relationship changed with algal culture conditions. In evaluating the influence of the initial algal concentration and recycle ratio revealed that, under conditions typical for algal harvesting, we found that itmore » is possible that the number of bubbles is insufficient. A DAF algal harvesting model was developed to explain this observation by introducing mass-based floc size distributions and a bubble limitation into the white water blanket model. Moreover, the model revealed the importance of coagulation to increase floc-bubble collision and attachment, and the preferential interaction of bubbles with larger flocs, which limited the availability of bubbles to the smaller sized flocs. The harvesting efficiencies predicted by the model agree reasonably with experimental data obtained at different Al3+ dosages, algal concentrations, and recycle ratios. Based on this modeling, critical parameters for efficient algal harvesting were identified.« less

  4. Effects of floc and bubble size on the efficiency of the dissolved air flotation (DAF) process.

    PubMed

    Han, Mooyoung; Kim, Tschung-il; Kim, Jinho

    2007-01-01

    Dissolved air flotation (DAF) is a method for removing particles from water using micro bubbles instead of settlement. The process has proved to be successful and, since the 1960s, accepted as an alternative to the conventional sedimentation process for water and wastewater treatment. However, limited research into the process, especially the fundamental characteristics of bubbles and particles, has been carried out. The single collector collision model is not capable of determining the effects of particular characteristics, such as the size and surface charge of bubbles and particles. Han has published a set of modeling results after calculating the collision efficiency between bubbles and particles by trajectory analysis. His major conclusion was that collision efficiency is maximum when the bubbles and particles are nearly the same size but have opposite charge. However, experimental verification of this conclusion has not been carried out yet. This paper describes a new method for measuring the size of particles and bubbles developed using computational image analysis. DAF efficiency is influenced by the effect of the recycle ratio on various average floc sizes. The larger the recycle ratio, the higher the DAF efficiency at the same pressure and particle size. The treatment efficiency is also affected by the saturation pressure, because the bubble size and bubble volume concentration are controlled by the pressure. The highest efficiency is obtained when the floc size is larger than the bubble size. These results, namely that the highest collision efficiency occurs when the particles and bubbles are about the same size, are more in accordance with the trajectory model than with the white water collector model, which implies that the larger the particles, the higher is the collision efficiency.

  5. Removal of pharmaceutical residue in municipal wastewater by DAF (dissolved air flotation)-MBR (membrane bioreactor) and ozone oxidation.

    PubMed

    Choi, Miyoung; Choi, Dong Whan; Lee, Jung Yeol; Kim, Young Suk; Kim, Bun Su; Lee, Byoung Ho

    2012-01-01

    Growing attention is given to pharmaceutical residue in the water environment. It is known that pharmaceuticals are able to survive from a series of wastewater treatment processes. Concerns regarding pharmaceutical residues are attributed to the fact that they are being detected in water and sediment environment ubiquitously. Pharmaceutical treatment using a series of wastewater treatment processes of the DAF (dissolved air flotation)-MBR (membrane bioreactor)-ozone oxidation was conducted in the study. DAF, without addition of coagulant, could remove COD(cr) (chemical oxygen demand by Cr) up to over 70%, BOD 73%, SS 83%, T-N 55%, NH₄(+) 23%, and T-P 65% in influent of municipal wastewater. Average removal rates of water quality parameters by the DAF-MBR system were very high, e.g. COD(cr) 95.88%, BOD₅ 99.66%, COD(mn) (chemical oxygen demand by Mn) 93.63%, T-N 69.75%, NH₄-N 98.46%, T-P 78.23%, and SS 99.51%, which satisfy effluent water quality standards. Despite the high removal rate of the wastewater treatment system, pharmaceuticals were eliminated to be about 50-99% by the MBR system, depending on specific pharmaceuticals. Ibuprofen was well removed by MBR system up to over 95%, while removal rate of bezafibrate ranged between 50 and 90%. With over 5 mg/l of ozone oxidation, most pharmaceuticals which survived the DAF-MBR process were removed completely or resulted in very low survival rate within the range of few micrograms per litre. However, some pharmaceuticals such as bezafibrate and naproxen tended to be resistant to ozone oxidation.

  6. Dissolved air flotation (DAF) for primary and tertiary treatment of municipal wastewaters.

    PubMed

    Koivunen, J; Heinonen-Tanski, H

    2008-01-01

    Tertiary treatment of municipal wastewater by dissolved air flotation was studied on a pilot-scale. The effects of coagulant dose, flocculation pattern, dispersion water recycle ratio and hydraulic surface load on process performance were evaluated. The treatment of primary effluents by dissolved air flotation was investigated to assess the suitability of this process for the treatment of heavily polluted effluents and wastewater treatment plant by-passes. The tertiary dissolved air flotation process typically achieved 90-99% reductions in the numbers of enteric microbes (total coliforms, enterococci and F-RNA coliphages). The average reductions of total phosphorus and chemical oxygen demand were 55-81% and 28-39%, respectively. Increasing the polyaluminium chloride coagulant dose from 2 to 10 mgAl(3+) l(-1) and the dispersion water recycle ratio from 11 to 22% improved the efficiency of the process. Changes in the flocculation conditions (range of G-values 10-55 s(-1); retention time 4-8 min) and hydraulic surface load (5 or 10 m h(-1)) did not clearly affect the process efficiency. The dissolved air flotation process decreased the numbers of enteric microbes and reduced total phosphorus, chemical oxygen demand and suspended solids from the primary treated wastewaters on average by 98-99.8%, 90%, 47% and 77%, respectively. The dissolved air flotation process was demonstrated to be a suitable method for efficient tertiary treatment of wastewaters, as well as for the elimination of peak pollution loads or by-pass wastewaters during the treatment plant overloading situations.

  7. 46 CFR 197.344 - Inflatable floatation devices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  8. 46 CFR 197.344 - Inflatable floatation devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  9. 46 CFR 197.344 - Inflatable floatation devices.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  10. 46 CFR 197.344 - Inflatable floatation devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  11. 46 CFR 197.344 - Inflatable floatation devices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  12. Clarifying the Misconception about the Principle of Floatation

    ERIC Educational Resources Information Center

    Yadav, Manoj K.

    2014-01-01

    This paper aims to clarify the misconception about the violation of the principle of floatation. Improper understanding of the definition of "displaced fluid" by a floating body leads to the misconception. With the help of simple experiments, this article shows that there is no violation of the principle of floatation.

  13. Multiple Chemosensory Defects in Daf-11 and Daf-21 Mutants of Caenorhabditis Elegans

    PubMed Central

    Vowels, J. J.; Thomas, J. H.

    1994-01-01

    Phenotypic analysis of the daf-11 and daf-21 mutants of Caenorhabditis elegans suggests that they have defects in components shared by processes analogous to vertebrate taste and olfaction. daf-11 and daf-21 mutations were previously shown to cause inappropriate response to the dauer-inducing pheromone. By mutational analysis and by disabling specific chemosensory sensilla with a laser, we show that neurons in the amphid sensilla are required for this pheromone response. Using behavioral assays, we find that daf-11 and daf-21 mutants are not defective in avoidance of certain non-volatile repellents, but are defective in taxis to non-volatile attractants. In addition, both mutants are defective in taxis to volatile attractants detected primarily by the amphid neuron AWC, but respond normally to volatile attractants detected primarily by AWA. We propose that daf-11 and daf-21 mediate sensory transduction for both volatile and non-volatile compounds in specific amphid neurons. PMID:7828815

  14. Chimeric CD46/DAF molecules reveal a cryptic functional role for SCR1 of DAF in regulating complement activation.

    PubMed

    Christiansen, D; Loveland, B; Kyriakou, P; Lanteri, M; Rubinstein, E; Gerlier, D

    2000-01-01

    Chimeric proteins using membrane cofactor (CD46) and decay accelerating factor (DAF or CD55) were generated to further investigate the functional domains involved in the regulation of human serum complement. Following activation of the classical pathway, the isolated substitution of CD46 SCR III (x3DAF) exhibited a modest regulatory activity comparable to that of CD46. The isolated substitution of CD46 SCR IV (x4DAF), and the combined CD46 SCR III+IV substitutions (x3/4DAF) were essentially as efficient as DAF. No regulation of C3b deposition was observed with the combined CD46 SCR I+II substitutions (x1/2DAF). When tested after activation of the alternative pathway, both the x3DAF and x3/4DAF chimeras failed to regulate C3b deposition, while the x4DAF chimera still displayed some activity. In contrast to that observed following classical pathway activation, the x1/2DAF chimera exhibited a similar efficiency to wild type CD46 and DAF in controlling C3b deposition. Using SCR specific antibodies, the regulatory activity of the x1/2DAF chimera against the alternative pathway was mapped to the first three distal SCR (i.e. DAF 1, DAF 2 and CD46 III). These data demonstrate that several combinations of SCR domains from two related complement regulators can result in functional molecules, and reveal a novel and cryptic functional role for DAF SCR1.

  15. Collision efficiency factor of bubble and particle (alpha bp) in DAF: theory and experimental verification.

    PubMed

    Han, M; Kim, W; Dockko, S

    2001-01-01

    The collision efficiency factor of bubble and particle (alpha bp) in dissolved air flotation (DAF) can be calculated theoretically by trajectory analysis, which takes into account both hydrodynamics and interparticle forces. To determine the theoretically optimum particle size for any given bubble size, a collision efficiency diagram for DAF was developed where collision efficiency is contoured on a plane of particle and bubble sizes for different conditions of particle zeta potential. A set of experiments tested the validity of the suggested collision efficiency diagram, and examined whether pretreatment is important and why slight coagulant overdosing and shorter flocculation times are generally preferred in DAF, both current accepted practice. Batch DAF reactors were used and kaolin samples were prepared from jar tests using different alum dosages and flocculation times. The particle size distribution, particle zeta potential, and turbidity removal in each experiment were measured, as were bubble size and zeta potential. The results agreed well with the predictions of the collision efficiency diagram and explained current practices. A collision efficiency diagram identifies the pretreatment goal, i.e., tailoring of the optimum characteristics required of particles (zeta potential and size) under existing operational bubble characteristic.

  16. Waste management in the meat processing industry: Conversion of paunch and DAF sludge into solid fuel.

    PubMed

    Hamawand, Ihsan; Pittaway, Pam; Lewis, Larry; Chakrabarty, Sayan; Caldwell, Justin; Eberhard, Jochen; Chakraborty, Arpita

    2017-02-01

    This article addresses the novel dewatering process of immersion-frying of paunch and dissolved air flotation (DAF) sludge to produce high energy pellets. Literature have been analysed to address the feasibility of replacing conventional boiler fuel at meat processing facilities with high energy paunch-DAF sludge pellets (capsules). The value proposition of pelleting and frying this mixture into energy pellets is based on a Cost-Benefit Analysis (CBA). The CBA is based on information derived from the literature and consultation with the Australian Meat Processing Industry. The calorific properties of a mixture of paunch cake solids and DAF sludge were predicted from literature and industry consultation to validate the product. This study shows that the concept of pelletizing and frying paunch is economically feasible. The complete frying and dewatering of the paunch and DAF sludge mixture produces pellets with energy content per kilogram equivalent to coal. The estimated cost of this new product is half the price of coal and the payback period is estimated to be between 1.8 and 3.2years. Further research is required for proof of concept, and to identify the technical challenges associated with integrating this technology into existing meat processing plants.

  17. Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies.

    PubMed

    Lin, F; Fukuoka, Y; Spicer, A; Ohta, R; Okada, N; Harris, C L; Emancipator, S N; Medof, M E

    2001-10-01

    Decay-accelerating factor (DAF) is a membrane regulator of C3 activation that protects self cells from autologous complement attack. In humans, DAF is uniformly expressed as a glycosylphosphatidylinositol (GPI)-anchored molecule. In mice, both GPI-anchored and transmembrane-anchored DAF proteins are produced, each of which can be derived from two different genes (Daf1 and Daf2). In this report, we describe a Daf1 gene knock-out mouse arising as the first product of a strategy for targeting one or both Daf genes. As part of the work, we characterize recently described monoclonal antibodies against murine DAF protein using deletion mutants synthesized in yeast, and then employ the monoclonal antibodies in conjunction with wild-type and the Daf1 knock-out mice to determine the tissue distribution of the mouse Daf1 and Daf2 gene products. To enhance the immunohistochemical detection of murine DAF protein, we utilized the sensitive tyramide fluorescence method. In wild-type mice, we found strong DAF labelling of glomeruli, airway and gut epithelium, the spleen, vascular endothelium throughout all tissues, and seminiferous tubules of the testis. In Daf1 knock-out mice, DAF labelling was ablated in most tissues, but strong labelling of the testis and splenic dendritic cells remained. In both sites, reverse transcription-polymerase chain reaction analyses identified both GPI and transmembrane forms of Daf2 gene-derived protein. The results have relevance for studies of in vivo murine DAF function and of murine DAF structure.

  18. dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest

    PubMed Central

    Moore, Brad T.; Jordan, James M.; Maxwell, Colin S.; Schindler, Adam J.; Baugh, L. Ryan

    2015-01-01

    Nutrient availability has profound influence on development. In the nematode C. elegans, nutrient availability governs post-embryonic development. L1-stage larvae remain in a state of developmental arrest after hatching until they feed. This “L1 arrest” (or "L1 diapause") is associated with increased stress resistance, supporting starvation survival. Loss of the transcription factor daf-16/FOXO, an effector of insulin/IGF signaling, results in arrest-defective and starvation-sensitive phenotypes. We show that daf-16/FOXO regulates L1 arrest cell-nonautonomously, suggesting that insulin/IGF signaling regulates at least one additional signaling pathway. We used mRNA-seq to identify candidate signaling molecules affected by daf-16/FOXO during L1 arrest. dbl-1/TGF-β, a ligand for the Sma/Mab pathway, daf-12/NHR and daf-36/oxygenase, an upstream component of the daf-12 steroid hormone signaling pathway, were up-regulated during L1 arrest in a daf-16/FOXO mutant. Using genetic epistasis analysis, we show that dbl-1/TGF-β and daf-12/NHR steroid hormone signaling pathways are required for the daf-16/FOXO arrest-defective phenotype, suggesting that daf-16/FOXO represses dbl-1/TGF-β, daf-12/NHR and daf-36/oxygenase. The dbl-1/TGF-β and daf-12/NHR pathways have not previously been shown to affect L1 development, but we found that disruption of these pathways delayed L1 development in fed larvae, consistent with these pathways promoting development in starved daf-16/FOXO mutants. Though the dbl-1/TGF-β and daf-12/NHR pathways are epistatic to daf-16/FOXO for the arrest-defective phenotype, disruption of these pathways does not suppress starvation sensitivity of daf-16/FOXO mutants. This observation uncouples starvation survival from developmental arrest, indicating that DAF-16/FOXO targets distinct effectors for each phenotype and revealing that inappropriate development during starvation does not cause the early demise of daf-16/FOXO mutants. Overall, this study

  19. Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer.

    PubMed

    Gelmedin, Verena; Brodigan, Thomas; Gao, Xin; Krause, Michael; Wang, Zhu; Hawdon, John M

    2011-01-01

    Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental arrested stage, called the dauer stage in C. elegans and the infective third-stage larva (L3) in hookworms. One of the key transcription factors that regulate entrance to and exit from developmental arrest is the forkhead transcription factor DAF-16/FoxO. During the dauer stage, DAF-16 is activated and localized in the nucleus. DAF-16 is negatively regulated by phosphorylation by the upstream kinase AKT, which causes DAF-16 to localize out of the nucleus and the worm to exit from dauer. DAF-16 is conserved in hookworms, and hypothesized to control recovery from L3 arrest during infection. Lacking reverse genetic techniques for use in hookworms, we used C. elegans complementation assays to investigate the function of Ancylostoma caninum DAF-16 during entrance and exit from L3 developmental arrest. We performed dauer switching assays and observed the restoration of the dauer phenotype when Ac-DAF-16 was expressed in temperature-sensitive dauer defective C. elegans daf-2(e1370);daf-16(mu86) mutants. AKT phosphorylation site mutants of Ac-DAF-16 were also able to restore the dauer phenotype, but surprisingly allowed dauer exit when temperatures were lowered. We used fluorescence microscopy to localize DAF-16 during dauer and exit from dauer in C. elegans DAF-16 mutant worms expressing Ac-DAF-16, and found that Ac-DAF-16 exited the nucleus during dauer exit. Surprisingly, Ac-DAF-16 with mutated AKT phosphorylation sites also exited the nucleus during dauer exit. Our results suggest that another mechanism may be involved in the regulation DAF-16 nuclear localization during recovery from developmental arrest.

  20. Hydrothermal sulfidation and floatation treatment of heavy-metal-containing sludge for recovery and stabilization.

    PubMed

    Liang, Yan-Jie; Chai, Li-Yuan; Min, Xiao-Bo; Tang, Chong-Jian; Zhang, Hai-Jing; Ke, Yong; Xie, Xian-De

    2012-05-30

    This study focuses on the application of hydrothermal sulfidation and floatation to treat the heavy-metal-containing sludge for recovery and stabilization. After the hydrothermal sulfidation, the sulfidation percentage of zinc and lead reach up to 85.0% and 75.4%, respectively. 33.3% of Zn, 58.9% of Pb and 68.8% of Cu can be recovered from the sludge by floatation. The lower recovery of ZnS attributes to its surface and structural characteristics. To compare these characteristics, three types of synthetic metal sulfide (ZnS, PbS and CuS) were prepared and examined with XRD, SEM and TEM. The poor floatability of the finely dispersed, round shape of ZnS can be improved by crystal modification in hydrothermal condition. With increasing the temperature and reaction time, the grain size of the ZnS increased from 7.95 nm to 44.28 nm and the recovery of Zn increased to from 33.3% to 72.8%. The TCLP results indicate that all the leached heavy metal concentrations of floatation tailings are under the allowable limit. No obvious increase of heavy metal concentration was observed in continuous leaching procedure. The presence of alkaline compounds after hydrothermal sulfidation might act as mineralogical scavengers of dissolved heavy metal released by sulfide oxidation to avoid the heavy metal pollution.

  1. Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans.

    PubMed

    Yu, Chan-Wei; How, Chun Ming; Liao, Vivian Hsiu-Chuan

    2016-05-01

    Arsenic is a known human carcinogen and high levels of arsenic contamination in food, soils, water, and air are of toxicology concerns. Nowadays, arsenic is still a contaminant of emerging interest, yet the effects of arsenic on aging process have received little attention. In this study, we investigated the effects and the underlying mechanisms of chronic arsenite exposure on the aging process in Caenorhabditis elegans. The results showed that prolonged arsenite exposure caused significantly decreased lifespan compared to non-exposed ones. In addition, arsenite exposure (100 μM) caused significant changes of age-dependent biomarkers, including a decrease of defecation frequency, accumulations of intestinal lipofuscin and lipid peroxidation in an age-dependent manner in C. elegans. Further evidence revealed that intracellular reactive oxygen species (ROS) level was significantly increased in an age-dependent manner upon 100 μM arsenite exposure. Moreover, the mRNA levels of transcriptional makers of aging (hsp-16.1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 μM). Finally, we showed that daf-16 mutant worms were more sensitive to arsenite exposure (100 μM) on lifespan and failed to induce the expression of its target gene sod-3 in aged daf-16 mutant under arsenite exposure (100 μM). Our study demonstrated that chronic arsenite exposure resulted in accelerated aging process in C. elegans. The overproduction of intracellular ROS and the transcription factor DAF-16/FOXO play roles in mediating the accelerated aging process by arsenite exposure in C. elegans. This study implicates a potential ecotoxicological and health risk of arsenic in the environment.

  2. Deployable Air Beam Fender System (DAFS): Energy Absorption Performance Analysis

    DTIC Science & Technology

    2007-03-30

    its energy absorption performance. Quarter-scale and full-scale models were evaluated and compared to protot ype tests for a variety of inflation...pressures, impact berthing conditions, and ballast levels. Model predictions were validated with correlated test data. The explicit FEA method captured...was used. In step 1, the fender was inflated to the specified inflation pressure and the acceleration caused by gravity (386.4 in./s 2) was applied

  3. Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.

    PubMed

    Spanier, Britta; Rubio-Aliaga, Isabel; Hu, Hao; Daniel, Hannelore

    2010-08-01

    The insulin-like signalling pathway is a central regulator of development, metabolism, stress resistance and lifespan in eukaryotes. Caenorhabditis elegans daf-2(e1370) animals with a loss-of-function mutation in the insulin-like receptor live twice as long as wild-type animals, and the additional knockout of the intestinal di- and tripeptide transporter pept-1 further increases lifespan by 60%. In assessing the underlying molecular mechanisms for this phenomenon, microarray-based transcriptome data sets of daf-2(e1370) and daf-2(e1370);pept-1(lg601) animals were compared with a focus on genes that showed significantly higher changes in expression levels in daf-2;pept-1 than in daf-2. We identified 187 genes with at least fourfold decreased transcript levels and 170 with more than a fourfold increase. A large fraction of the down-regulated genes encode proteins involved in germline proliferation and reproduction. The DAF-9/DAF-12 signalling cascade was identified as a prime pathway that mediates the longevity of daf-2;pept-1 with a strict dependance on DAF-16. Loss of DAF-9/DAF-12 or KRI-1 reduces the lifespan of daf-2;pept-1 to that of the daf-2 mutant. Amongst the DAF-16 target genes, numerous enzymes involved in the defence of reactive oxygen species were with increased expression level in daf-2;pept-1. On a functional level, it was demonstrated that amongst those, a high de novo synthesis rate of glutathione is most important for the longevity phenotype of this strain. Taken together, a close interdependence of endocrine hormone signalling from germline to intestine was identified as an essential element in the control of the extreme longevity of C. elegans lacking a proper function of the insulin receptor and lacking the intestinal peptide transporter.

  4. Methods to Detect Nitric Oxide in Plants: Are DAFs Really Measuring NO?

    PubMed

    Ruemer, Stefan; Krischke, Markus; Fekete, Agnes; Lesch, Maria; Mueller, Marin J; Kaiser, Werner M

    2016-01-01

    Nitric oxide, a gaseous radical molecule, appears involved in many reactions in all living organisms. Fluorescent dyes like DAF-2 and related compounds are still widely used to monitor NO production inside or outside cells, although doubts about their specificity have recently been raised. We present evidence that DAF dyes do not only react with nitric oxide but also with peroxidase enzyme and hydrogen peroxide. Both are secreted in the case of elicitation of tobacco suspension cells with cryptogein, with a fluorescence increase mimicking NO release from cells. However, HPLC separation shows that fluorescence outside cells does not at all originate from DAF-2T, the product of DAF-2 and NO, but from other yet unidentified compounds. Inside cells, other DAF molecules are formed but only a minor part is DAF-2T. The chemical nature of the novel DAF derivatives still needs to be determined.

  5. Device Assembly Facility (DAF) Glovebox Radioactive Waste Characterization

    SciTech Connect

    Dominick, J L

    2001-12-18

    The Device Assembly Facility (DAF) at the Nevada Test Site (NTS) provides programmatic support to the Joint Actinide Shock Physics Experimental Research (JASPER) Facility in the form of target assembly. The target assembly activities are performed in a glovebox at DAF and include Special Nuclear Material (SNM). Currently, only activities with transuranic SNM are anticipated. Preliminary discussions with facility personnel indicate that primarily two distributions of SNM will be used: Weapons Grade Plutonium (WG-Pu), and Pu-238 enhanced WG-Pu. Nominal radionuclide distributions for the two material types are included in attachment 1. Wastes generated inside glove boxes is expected to be Transuranic (TRU) Waste which will eventually be disposed of at the Waste Isolation Pilot Plant (WIPP). Wastes generated in the Radioactive Material Area (RMA), outside of the glove box is presumed to be low level waste (LLW) which is destined for disposal at the NTS. The process knowledge quantification methods identified herein may be applied to waste generated anywhere within or around the DAF and possibly JASPER as long as the fundamental waste stream boundaries are adhered to as outlined below. The method is suitable for quantification of waste which can be directly surveyed with the Blue Alpha meter or swiped. An additional quantification methodology which requires the use of a high resolution gamma spectroscopy unit is also included and relies on the predetermined radionuclide distribution and utilizes scaling to measured nuclides for quantification.

  6. DAF as a therapeutic target for steroid hormones: implications for host-pathogen interactions.

    PubMed

    Nowicki, Bogdan; Nowicki, Stella

    2013-01-01

    In this chapter, we present a concise historic prospective and a summary of accumulated knowledge on steroid hormones, DAF expression, and therapeutic implication of steroid hormone treatment on multiple pathologies, including infection and the host-pathogen interactions. DAF/CD55 plays multiple physiologic functions including tissue protection from the cytotoxic complement injury, an anti-inflammatory function due to its anti-adherence properties which enhance transmigration of monocytes and macrophages and reduce tissue injury. DAF physiologic functions are essential in many organ systems including pregnancy for protection of the semiallogeneic fetus or for preventing uncontrolled infiltration by white cells in their pro- and/or anti-inflammatory functions. DAF expression appears to have multiple regulatory tissue-specific and/or menstrual cycle-specific mechanisms, which involve complex signaling mechanisms. Regulation of DAF expression may involve a direct or an indirect effect of at least the estrogen, progesterone, and corticosteroid regulatory pathways. DAF is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes. The binding of Escherichia coli bearing Dr adhesins to the DAF/CD55 receptor is DAF density dependent and triggers internalization of E. coli via an endocytic pathway involving CD55, lipid rafts, and microtubules. Dr+ E. coli or Dr antigen may persist in vivo in the interstitium for several months. Further understanding of such processes should be instrumental in designing therapeutic strategies for multiple conditions involving DAF's protective or pathologic functions and tailoring host expression of DAF.

  7. Molecular cloning and DNA binding characterization of DAF-16 orthologs from Ancylostoma hookworms⋆

    PubMed Central

    Gao, Xin; Frank, Daniel; Hawdon, John M.

    2009-01-01

    Infective hookworm L3s encounter a host-specific signal during infection that re-initiates a suspended developmental pathway, resulting in development to the adult stage. This resumption of development in the host is analogous to recovery of developmentally arrested Caenorhabditis elegans dauer larvae in response to favorable environmental signals. Dauer recovery in C. elegans dauers and hookworm L3s is mediated by insulin-like signaling (ILS). A key output of ILS in C. elegans is the forkhead transcription factor DAF-16, which controls the expression of genes required for maintenance of the dauer stage. The similarity between recovery pathways of L3s and dauers suggests that DAF-16 functions similarly in hookworm L3 activation. To test this, orthologs of Ce-DAF-16 were isolated from the hookworms Ancylostoma caninum and Ancylostoma ceylanicum. The protein sequences of hookworm DAF-16 DNA binding domains were identical, and shared 94% identity with the b and c isoforms of Ce-DAF-16. Ac-DAF-16 expressed in HEK293 kidney cells bound strongly to the conserved DAF family binding element (DBE), but not to a random DNA sequence. Ac-DAF-16 was able to drive transcription of a reporter gene located downstream of six copies of the DBE in NIH3T3 cells under starved conditions. Addition of serum caused a decrease in reporter gene expression, indicating that DAF-16 is negatively regulated by growth factor stimulation. These data confirm the presence of DAF-16 orthologs in hookworms, and demonstrate that Ac-DAF-16 binds to and drives transcription from a conserved DAF-16 family DNA binding element. PMID:18930062

  8. The Development of an Innovative Vertical Floatation Melter and Scrap Dryer for Use in the Aluminum Processing Industry

    SciTech Connect

    Robert De Saro

    2004-08-24

    The project aimed at the development of a Vertical Floatation melter, for application to the aluminum industry. This is intended to improve both the energy efficiency and environmental performance of aluminum melting furnaces. Phase I of this project dealt primarily with the initial research effort. Phase II, dealt with pilot-scale testing.

  9. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity

    PubMed Central

    Heimbucher, Thomas; Liu, Zheng; Bossard, Carine; McCloskey, Richard; Carrano, Andrea C.; Riedel, Christian G.; Tanasa, Bogdan; Klammt, Christian; Fonslow, Bryan R.; Riera, Celine E.; Lillemeier, Bjorn F.; Kemphues, Kenneth; Yates, John R.; O'Shea, Clodagh; Hunter, Tony; Dillin, Andrew

    2015-01-01

    SUMMARY One of the major determinants of aging in organisms ranging from worms to man are FOXO family transcription factors, which are downstream effectors of Insulin/IGF-1 signaling (IIS). The molecular mechanisms that actively promote DAF16/FOXO stability and function are unknown. Here we identify the deubiquitylating enzyme MATH-33 as an essential DAF-16 regulator in IIS, which stabilizes active DAF-16 protein levels and, as a consequence, influences DAF-16 functions, such as metabolism, stress response and longevity in C. elegans. MATH-33 associates with DAF-16 in cellulo and in vitro. MATH-33 functions as a deubiquitylase by actively removing ubiquitin moieties from DAF-16, thus counteracting the action of the RLE-1 E3-ubiquitin ligase. Our findings support a model in which MATH-33 promotes DAF-16 stability in response to decreased IIS by directly modulating its ubiquitylation state, suggesting that regulated oscillations in the stability of DAF-16 protein play an integral role in controlling processes such as metabolism and longevity. PMID:26154057

  10. Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

    PubMed Central

    Kumar, Neeraj; Jagtap, Urmila; Verma, Sonia; Mukhopadhyay, Arnab

    2015-01-01

    Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal region results in maximum induction of downstream targets that code for proteins involved in detoxification and longevity. Interestingly, genes that are activated under low IIS already have higher DAF-16 recruited to their promoters in WT. DAF-16 binds to variants of the FOXO consensus sequence in the promoter proximal regions of genes that are exclusively targeted during low IIS. We also define a set of ‘core’ direct targets, after comparing multiple studies, which tend to co-express and contribute robustly towards IIS-associated phenotypes. Additionally, we show that nuclear hormone receptor DAF-12 as well as zinc-finger TF EOR-1 may bind DNA in close proximity to DAF-16 and distinct TF classes that are direct targets of DAF-16 may be instrumental in regulating its indirect targets. Together, our study provides fundamental insights into the transcriptional biology of FOXO/DAF-16 and gene regulation downstream of the IIS pathway. PMID:26539642

  11. Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells▿

    PubMed Central

    Patel, Kunal P.; Coyne, Carolyn B.; Bergelson, Jeffrey M.

    2009-01-01

    Group B coxsackieviruses (CVB) use the CVB and adenovirus receptor (CAR) to enter and infect cells. Some CVB also bind to decay-accelerating factor (DAF), but that interaction alone is insufficient for infection. We previously found that CVB3 entry into polarized human intestinal cells (Caco-2) occurs by a caveolin-dependent but dynamin-independent mechanism that requires DAF-mediated tyrosine kinase signals. In this study, we examined how CVB enter and infect nonpolarized HeLa cells and how DAF binding affects these processes. Using immunofluorescence microscopy and a combination of dominant-negative proteins, small interfering RNAs, and drugs targeting specific endocytic pathways, we found that both DAF-binding and non-DAF-binding virus isolates require dynamin and lipid rafts to enter and infect cells. Unlike what we observed in Caco-2 cells, CVB3 entered HeLa cells with CAR. We found no role for clathrin, endosomal acidification, or caveolin. Inhibition of tyrosine kinases blocked an early event in infection but did not prevent entry of virus into the cell. These results indicate that CVB3 entry into nonpolarized HeLa cells differs significantly from entry into polarized Caco-2 cells and is not influenced by virus binding to DAF. PMID:19710132

  12. Modulation of PBMC-decay accelerating factor (PBMC-DAF) and cytokines in rheumatoid arthritis.

    PubMed

    Pahwa, Roma; Kumar, Uma; Das, Nibhriti

    2016-03-01

    Studies have suggested that abnormal expression of complement regulatory proteins and cytokines contribute significantly to the path-physiology of rheumatoid arthritis. In this context, Decay accelerating factor (DAF) a complement regulatory protein is gaining increased attention. With the notion that immune effecter mechanisms are all interlinked and circulating peripheral blood mononuclear cells (PBMCs) should have a role in a systemic disease like rheumatoid arthritis, we studied the modulation and significance of PBMC-DAF and cytokines in RA. Seventy-five RA patients and 75 healthy controls were recruited. Expression of DAF and cytokines (IFN-γ, IL-17A and IL-10) in the PBMCs of patients and controls was determined. Correlations among DAF, cytokines, and disease activity were evaluated by standard statistical methods. The effect of IFN-γ, IL-17A, and IL-10 on the expression of DAF in patients and controls was studied in vitro. Expression of PBMC-DAF declined in patients both at mRNA and surface level and correlated negatively with the disease activity. Expression of IFN-γ also declined in patients but correlated positively with DAF and negatively with disease activity. Expression of IL-17A and IL-10 was higher in patients. The levels correlated positively with disease activity and negatively with DAF both in patients and controls. In vitro studies indicated that IFN-γ up-regulated DAF expression in PBMCs, whereas IL-17A and IL-10 had negative effect on the same. The decline in the PBMC-DAF is a contributing factor in manifestations of RA. Cytokine environment contributes to this decline. These findings brought novel insights into the complement-cytokine axis in the path-physiology of RA.

  13. Diaminofurazan (DAF): Thermolysis and evaluation as ballistic modifier in double base propellant.

    PubMed

    Talawar, M B; Nair, J K; Pundalik, S M; Satpute, R S; Venugopalan, S

    2006-08-25

    Diaminofurazan (DAF) is used as a precursor in the synthesis of many high performance insensitive high explosives. This paper reports the thermal studies on DAF and its evaluation as a ballistic modifier in double base propellant formulations. Differential scanning calorimetry (DSC) and differential thermal analysis (DTA) revealed that DAF shows two-stage decomposition, whereas the kinetics of initial stage of thermal decomposition of DAF evaluated from TG data gave activation energy (E(a)) of 67 kJ mol(-1). The evolution of gases containing species such as CN, NH, OH and oxides of nitrogen during thermal decomposition of DAF was also revealed by hyphenated TG-FTIR data. Evaluation of DAF as a ballistic modifier in RDX incorporated double base propellant formulations indicated that it brings down the pressure index to 0.20 compared to 0.70 for a control composition in the pressure range 6.9-8.8 MPa when used in combination with basic lead salicylate (BLS). It was observed that DAF does not have adverse effect on vulnerability and chemical stability of the propellant formulation.

  14. Cryptosporidium Oocyst Detection in Water Samples: Floatation Technique Enhanced with Immunofluorescence Is as Effective as Immunomagnetic Separation Method

    PubMed Central

    Koompapong, Khuanchai; Sutthikornchai, Chantira

    2009-01-01

    Cryptosporidium can cause gastrointestinal diseases worldwide, consequently posing public health problems and economic burden. Effective techniques for detecting contaminated oocysts in water are important to prevent and control the contamination. Immunomagnetic separation (IMS) method has been widely employed recently due to its efficiency, but, it is costly. Sucrose floatation technique is generally used for separating organisms by using their different specific gravity. It is effective and cheap but time consuming as well as requiring highly skilled personnel. Water turbidity and parasite load in water sample are additional factors affecting to the recovery rate of those 2 methods. We compared the efficiency of IMS and sucrose floatation methods to recover the spiked Cryptosporidium oocysts in various turbidity water samples. Cryptosporidium oocysts concentration at 1, 101, 102, and 103 per 10 µl were spiked into 3 sets of 10 ml-water turbidity (5, 50, and 500 NTU). The recovery rate of the 2 methods was not different. Oocyst load at the concentration < 102 per 10 ml yielded unreliable results. Water turbidity at 500 NTU decreased the recovery rate of both techniques. The combination of sucrose floatation and immunofluorescense assay techniques (SF-FA) showed higher recovery rate than IMS and immunofluorescense assay (IMS-FA). We used this SF-FA to detect Cryptosporidium and Giardia from the river water samples and found 9 and 19 out of 30 (30% and 63.3%) positive, respectively. Our results favored sucrose floatation technique enhanced with immunofluorescense assay for detecting contaminated protozoa in water samples in general laboratories and in the real practical setting. PMID:19967082

  15. Cryptosporidium oocyst detection in water samples: floatation technique enhanced with immunofluorescence is as effective as immunomagnetic separation method.

    PubMed

    Koompapong, Khuanchai; Sutthikornchai, Chantira; Sukthana, Yowalark

    2009-12-01

    Cryptosporidium can cause gastrointestinal diseases worldwide, consequently posing public health problems and economic burden. Effective techniques for detecting contaminated oocysts in water are important to prevent and control the contamination. Immunomagnetic separation (IMS) method has been widely employed recently due to its efficiency, but, it is costly. Sucrose floatation technique is generally used for separating organisms by using their different specific gravity. It is effective and cheap but time consuming as well as requiring highly skilled personnel. Water turbidity and parasite load in water sample are additional factors affecting to the recovery rate of those 2 methods. We compared the efficiency of IMS and sucrose floatation methods to recover the spiked Cryptosporidium oocysts in various turbidity water samples. Cryptosporidium oocysts concentration at 1, 10(1), 10(2), and 10(3) per 10 microl were spiked into 3 sets of 10 ml-water turbidity (5, 50, and 500 NTU). The recovery rate of the 2 methods was not different. Oocyst load at the concentration < 10(2) per 10 ml yielded unreliable results. Water turbidity at 500 NTU decreased the recovery rate of both techniques. The combination of sucrose floatation and immunofluorescense assay techniques (SF-FA) showed higher recovery rate than IMS and immunofluorescense assay (IMS-FA). We used this SF-FA to detect Cryptosporidium and Giardia from the river water samples and found 9 and 19 out of 30 (30% and 63.3%) positive, respectively. Our results favored sucrose floatation technique enhanced with immunofluorescense assay for detecting contaminated protozoa in water samples in general laboratories and in the real practical setting.

  16. Enhanced phosphorus removal in the DAF process by flotation scum recycling for advanced treatment of municipal wastewater.

    PubMed

    Kwak, Dong-Heui; Lee, Ki-Cheol

    2015-01-01

    To remove phosphorus (P) from municipal wastewater, various types of advanced treatment processes are being actively applied. However, there is commonly a space limit in municipal wastewater treatment plants (MWTPs). For that reason, the dissolved air flotation (DAF), which is well known for small space and flexible application process, is preferred as an additive process to enhance the removal of P. A series of experiments were conducted to investigate the feasibility of flotation scum recycling for effective P removal from a MWTP using a DAF pilot plant over 1 year. The average increases in the removal efficiencies due to flotation scum recycling were 22.6% for total phosphorus (T-P) and 18.3% for PO4-P. A higher removal efficiency of T-P was induced by recycling the flotation scum because a significant amount of Al components remained in the flotation scum. The increase in T-P removal efficiency, due to the recycling of flotation scum, shifted from the boundary of the stoichiometric precipitate to the equilibrium control region. Flotation scum recycling may contribute to improving the quality of treated water and reducing treatment costs by minimizing the coagulant dosage required.

  17. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.

    PubMed

    Estevez, M; Attisano, L; Wrana, J L; Albert, P S; Massagué, J; Riddle, D L

    1993-10-14

    The bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth factor-beta (TGF-beta) superfamily. This group, including the Drosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-beta receptor serine/threonine kinases. When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.

  18. The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

    PubMed Central

    Wang, Zhu; Stoltzfus, Jonathan; You, Young-jai; Ranjit, Najju; Tang, Hao; Xie, Yang; Lok, James B.; Mangelsdorf, David J.; Kliewer, Steven A.

    2015-01-01

    Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases. PMID:25774872

  19. Functional Conservation and Divergence of daf-22 Paralogs in Pristionchus pacificus Dauer Development.

    PubMed

    Markov, Gabriel V; Meyer, Jan M; Panda, Oishika; Artyukhin, Alexander B; Claaßen, Marc; Witte, Hanh; Schroeder, Frank C; Sommer, Ralf J

    2016-10-01

    Small-molecule signaling in nematode dauer formation has emerged as a major model to study chemical communication in development and evolution. Developmental arrest as nonfeeding and stress-resistant dauer larvae represents the major survival and dispersal strategy. Detailed studies in Caenorhabditis elegans and Pristionchus pacificus revealed that small-molecule communication changes rapidly in evolution resulting in extreme structural diversity of small-molecule compounds. In C. elegans, a blend of ascarosides constitutes the dauer pheromone, whereas the P. pacificus dauer pheromone includes additional paratosides and integrates building blocks from diverse primary metabolic pathways. Despite this complexity of small-molecule structures and functions, little is known about the biosynthesis of small molecules in nematodes outside C. elegans Here, we show that the genes encoding enzymes of the peroxisomal β-oxidation pathway involved in small-molecule biosynthesis evolve rapidly, including gene duplications and domain switching. The thiolase daf-22, the most downstream factor in C. elegans peroxisomal β-oxidation, has duplicated in P. pacificus, resulting in Ppa-daf-22.1, which still contains the sterol-carrier-protein (SCP) domain that was lost in C. elegans daf-22, and Ppa-daf-22.2. Using the CRISPR/Cas9 system, we induced mutations in both P. pacificus daf-22 genes and identified an unexpected complexity of functional conservation and divergence. Under well-fed conditions, ascaroside biosynthesis proceeds exclusively via Ppa-daf-22.1 In contrast, starvation conditions induce Ppa-daf-22.2 activity, resulting in the production of a specific subset of ascarosides. Gene expression studies indicate a reciprocal up-regulation of both Ppa-daf-22 genes, which is, however, independent of starvation. Thus, our study reveals an unexpected functional complexity of dauer development and evolution.

  20. Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor

    PubMed Central

    Sharma, Kamalesh K.; Wang, Zhu; Motola, Daniel L.; Cummins, Carolyn L.; Mangelsdorf, David J.; Auchus, Richard J.

    2009-01-01

    The nuclear hormone receptor DAF-12 from Caenorhabditis elegans is activated by dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450. DAF-12 activation is a critical checkpoint in C. elegans for acquisition of reproductive competence and for entry into adulthood rather than dauer diapause. Previous studies implicated the (25S)-Δ7-dafachronic acid isomer as the most potent compound, but the (25S)-Δ4-isomer was also identified as an activator of DAF-12. To explore the tolerance of DAF-12 for structural variations in the ligand and to enable further studies requiring large amounts of ligands for DAF-12 and homologs in other nematodes, we synthesized (25R)- and (25S)-isomers of five dafachronic acids differing in A/B-ring configurations. Both the (25S)- and (25R)-Δ7-dafachronic acids are potent transcriptional activators in a Gal4-transactivation assay using HEK-293 cells, with EC50 values of 23 and 33 nm, respectively, as are (25S)- and (25R)-Δ4-dafachronic acids, with EC50 values of 23 and 66 nm, respectively. The (25S)- and (25R)-Δ5-isomers were much less potent, with EC50 values approaching 1000 nm, and saturated 5α- and 5β-dafachronic acids showed mostly intermediate potencies. Rescue assays using daf- 9-null mutants confirmed the results from transactivation experiments, but this in vivo assay accentuated the greater potencies of the (25S)-epimers, particularly for the (25S)-Δ7-isomer. We conclude that DAF-12 accommodates a large range of structural variation in ligand geometry, but (25S)-Δ7-dafachronic acid is the most potent and probably biologically relevant isomer. Potency derives more from the A/B-ring configuration than from the stereochemistry at C-25. PMID:19196833

  1. daf-7 and the development of Strongyloides ratti and Parastrongyloides trichosuri.

    PubMed

    Crook, Matt; Thompson, Fiona J; Grant, Warwick N; Viney, Mark E

    2005-02-01

    daf-7 is a key ligand in one of the three pathways that control dauer larva development in Caenorhabditis elegans. Given the similarities between dauer larvae of free-living nematodes and third stage infective larvae of animal parasitic nematodes, we hypothesised that daf-7 may be involved in the development of these infective larvae. To investigate this, we cloned daf-7 orthologues from Strongyloides ratti and Parastrongyloides trichosuri and analysed their RNA level by semi-quantitative RT-PCR during the S. ratti and P. trichosuri life cycles and in a range of in vitro and in vivo conditions. We found that, in both species, the RNA level of daf-7 was low in free-living stages but peaked in the infective L3 (iL3) stage with little or no expression in the parasitic stages. This contrasts with the daf-7 RNA level in C. elegans, which peaks in L1, decreases thereafter, and is absent in dauer larvae. The RNA level of daf-7 in infective larvae was reduced by larval penetration of host skin or development in the host, but not by a shift to the body temperature of the host.

  2. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

    PubMed

    Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

    2012-09-01

    FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

  3. Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.

    PubMed

    Chen, Albert Tzong-Yang; Guo, Chunfang; Itani, Omar A; Budaitis, Breane G; Williams, Travis W; Hopkins, Christopher E; McEachin, Richard C; Pande, Manjusha; Grant, Ana R; Yoshina, Sawako; Mitani, Shohei; Hu, Patrick J

    2015-10-01

    FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative analysis of isoform-specific daf-16/FoxO mutants. In contrast to previous studies suggesting that DAF-16F plays a more prominent role in life span control than DAF-16A, isoform-specific daf-16/FoxO mutant phenotypes and whole transcriptome profiling revealed a predominant role for DAF-16A over DAF-16F in life span control, stress resistance, and target gene regulation. Integration of these datasets enabled the prioritization of a subset of 92 DAF-16/FoxO target genes for functional interrogation. Among 29 genes tested, two DAF-16A-specific target genes significantly influenced longevity. A loss-of-function mutation in the conserved gene gst-20, which is induced by DAF-16A, reduced life span extension in the context of daf-2/IGFR RNAi without influencing longevity in animals subjected to control RNAi. Therefore, gst-20 promotes DAF-16/FoxO-dependent longevity. Conversely, a loss-of-function mutation in srr-4, a gene encoding a seven-transmembrane-domain receptor family member that is repressed by DAF-16A, extended life span in control animals, indicating that DAF-16/FoxO may extend life span at least in part by reducing srr-4 expression. Our discovery of new longevity genes underscores the efficacy of our integrative strategy while providing a general framework for identifying specific downstream gene regulatory events that contribute substantially to transcription factor functions. As FoxO transcription factors have conserved functions in promoting longevity and may be dysregulated in aging-related diseases, these findings promise to illuminate fundamental

  4. Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans

    PubMed Central

    Li, Yan-Hui; Zhang, Gai-Gai

    2016-01-01

    DAF-16, the C. elegans FOXO transcription factor, is an important determinant in aging and longevity. In this work, we manually curated FOXODB http://lyh.pkmu.cn/foxodb/, a database of FOXO direct targets. It now covers 208 genes. Bioinformatics analysis on 109 DAF-16 direct targets in C. elegans found interesting results. (i) DAF-16 and transcription factor PQM-1 co-regulate some targets. (ii) Seventeen targets directly regulate lifespan. (iii) Four targets are involved in lifespan extension induced by dietary restriction. And (iv) DAF-16 direct targets might play global roles in lifespan regulation. PMID:27027346

  5. Improving the removal of anions by coagulation and dissolved air flotation in wastewater reclamation.

    PubMed

    Chuang, S H; Chang, W C; Chang, T C; You, S J

    2006-05-01

    This study investigated the feasibility of improving the removal of anions from a secondary effluent by coagulation/flocculation (Coag/Floc) and dissolved air flotation (DAF) using a pilot-scale wastewater reclamation plant in a high-tech industrial park. The pilot plant was equipped with units of Coag/Floc, DAF, activated carbon beds (AC), microfiltration modules (MF) and a reverse-osmosis membrane (RO). It was operated in-situ continuously for around one year to evaluate the performance of anion removal in two processes - the AC-RO process and the DAF-AC-RO process. Long-term experimental results indicated that combining Coag/Floc, DAF and AC units increased the potential of pretreatment to remove anions. The removal efficiencies in Coag/Floc-DAF units were in the order phosphate > fluoride > chloride > sulfate > silicate. The charged complex of PACl flocs revealed a higher affinity for adsorption onto phosphate and fluoride than on chloride, sulfate and silicate. Comparison of the performance of Coag/Floc-DAF-AC units in the DAF-AC-RO process with that of a single AC unit in the AC-RO process demonstrated that adding Coag/Floc-DAF units increased the removal efficiencies of phosphate, fluoride and silicate by approximately 70.0%, 42.7% and 70.1%, respectively. Most of the phosphate and fluoride were removed in Coag/Floc-DAF units, while most of the silicate escaped from the Coag/Floc-DAF units, and was adsorbed and/or trapped in the AC unit. The quality of reclaimed water in the DAF-AC-RO process complied with the requirements of high-tech industries in cleaning processes. Combined units of Coag/Floc-DAF-AC were therefore recommended for use in pretreatment in wastewater reclamation in high-tech industrial parks.

  6. The longevity effect of echinacoside in Caenorhabditis elegans mediated through daf-16.

    PubMed

    Wang, Xue; Zhang, Jiaolong; Lu, Lulu; Zhou, Lijun

    2015-01-01

    Echinacoside (ECH), a natural polyphenolic compound, has been reported to possess important pharmacological activities. However, very little is known about whether or how ECH affects longevity in vivo. We have examined the effects of ECH on the life span and stress tolerance in Caenorhabditis elegans. Our studies demonstrate that the life span of wild-type worms could be extended in the presence of ECH. Furthermore, ECH was found to increase tolerance of worms to heat shock and oxidative stress, while not exerting any influence on pharyngeal pumping rate and progeny production. Our mechanistic studies indicate that supplementation of ECH increases the transcript level of daf-16. ECH treatment also modulates the nuclear localization and transcriptional activities of daf-16, thus fine tunes the expression of daf-16 target genes to promote longevity and increases stress response in C. elegans. Overall, this work reveals the longevity effect of ECH and elucidates the underpinning mechanisms.

  7. DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

    PubMed Central

    Yen, Kelvin; Narasimhan, Sri Devi

    2011-01-01

    Abstract The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes. Antioxid. Redox Signal. 14, 623–634. PMID:20673162

  8. DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.

    PubMed

    Savory, Fiona R; Sait, Steven M; Hope, Ian A

    2011-01-01

    In Caenorhabditis elegans, mutants of the conserved insulin/IGF-1 signalling (IIS) pathway are long-lived and stress resistant due to the altered expression of DAF-16 target genes such as those involved in cellular defence and metabolism. The three Δ(9) desaturase genes, fat-5, fat-6 and fat-7, are included amongst these DAF-16 targets, and it is well established that Δ(9) desaturase enzymes play an important role in survival at low temperatures. However, no assessment of cold tolerance has previously been reported for IIS mutants. We demonstrate that long-lived age-1(hx546) mutants are remarkably resilient to low temperature stress relative to wild type worms, and that this is dependent upon daf-16. We also show that cold tolerance following direct transfer to low temperatures is increased in wild type worms during the facultative, daf-16 dependent, dauer stage. Although the cold tolerant phenotype of age-1(hx546) mutants is predominantly due to the Δ(9) desaturase genes, additional transcriptional targets of DAF-16 are also involved. Surprisingly, survival of wild type adults following a rapid temperature decline is not dependent upon functional daf-16, and cellular distributions of a DAF-16::GFP fusion protein indicate that DAF-16 is not activated during low temperature stress. This suggests that cold-induced physiological defences are not specifically regulated by the IIS pathway and DAF-16, but expression of DAF-16 target genes in IIS mutants and dauers is sufficient to promote cross tolerance to low temperatures in addition to other forms of stress.

  9. The Future of Architecture Collaborative Information Sharing: DoDAF Version 2.03 Updates

    DTIC Science & Technology

    2012-04-30

    Salamander x Select Solution Factory Select Business Solutions BPMN , UML x SimonTool Simon Labs x SimProcess CACI BPMN x System Architecture Management...for DoDAF Mega UML x Metastorm ProVision Metastorm BPMN x Naval Simulation System - 4 Aces METRON x NetViz CA x OPNET OPNET x Tool Name Vendor Primary

  10. Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.

    PubMed

    Wolf, Tim; Qi, Wenjing; Schindler, Verena; Runkel, Eva Diana; Baumeister, Ralf

    2014-08-01

    Managing available resources is a key necessity of each organism to cope with the environment. The nematode C. elegans responds to nutritional deprivation or harsh environmental conditions with a multitude of developmental adaptations, among them a starvation-induced quiescence at early larval development (L1). daf-18, the C. elegans homolog of the human tumor suppressor gene PTEN, is essential for the maintenance of survival and germline stem cell arrest during the L1 diapause. We show here that daf-18 mutants, independently to their failure to maintain G2 arrest of the primordial germ cells, develop a gonad phenotype after refeeding. This highly penetrant gonadal phenotype is further enhanced by a mutation in shc-1, encoding a protein homologous to the human adaptor ShcA. Features of this phenotype are a tumor-like phenotype encompassing hyper-proliferation of germ cell nuclei and disruption/invasion of the basement membrane surrounding the gonad. The penetrance of this phenotype is reduced by decreasing starvation temperature. In addition, it is also ameliorated in a dose-dependent way by exposure to the antibiotic doxycyclin either during starvation or during subsequent refeeding. Since, in eukaryotic cells, doxycyclin specifically blocks mitochondrial translation, our results suggest that daf-18 and shc-1;daf-18 mutants fail to adapt mitochondrial activity to reduced nutritional availability during early larval developing.

  11. TsDAF-21/Hsp90 is expressed in all examined stages of Trichinella spiralis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Trichinella is an important parasitic nematode of animals worldwide. Heat shock proteins are ubiquitous in nature and allow organisms to quickly respond to environmental stress. A portion of the Tsdaf-21 gene, a Caenorhabditis elegans daf-21 homologue encoding heat-shock protein 90 (Hsp90) was clone...

  12. High Energy X-Ray System Specification for the Device Assembly Facility (DAF) at the NNSS

    SciTech Connect

    Fry, David A.

    2012-08-10

    This specification establishes requirements for an X-Ray System to be used at the Device Assembly Facility (DAF) at the Nevada National Security Site (NNSS) to support radiography of experimental assemblies for Laboratory (LANL, LLNL, SNL) programs conducting work at the NNSS.

  13. Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16

    PubMed Central

    Büchter, Christian; Ackermann, Daniela; Havermann, Susannah; Honnen, Sebastian; Chovolou, Yvonni; Fritz, Gerhard; Kampkötter, Andreas; Wätjen, Wim

    2013-01-01

    Myricetin is a naturally occurring flavonol found in many plant based food sources. It increases the lifespan of Caenorhabditis elegans, but the molecular mechanisms are not yet fully understood. We have investigated the impact of this flavonoid on the transcription factors DAF-16 (C. elegans FoxO homologue) and SKN-1 (Nrf2 homologue), which have crucial functions in the regulation of ageing. Myricetin is rapidly assimilated by the nematode, causes a nuclear translocation of DAF-16 but not of SKN-1, and finally prolongs the mean adult lifespan of C. elegans by 32.9%. The lifespan prolongation was associated with a decrease in the accumulation of reactive oxygen species (ROS) detected by DCF. Myricetin also decreases the formation of lipofuscin, a pigment consisting of highly oxidized and cross-linked proteins that is considered as a biomarker of ageing in diverse species. The lifespan extension was completely abolished in a daf-16 loss-of-function mutant strain (CF1038). Consistently with this result, myricetin was also not able to diminish stress-induced ROS accumulation in the mutant. These results strongly indicate that the pro-longevity effect of myricetin is dependent on DAF-16 and not on direct anti-oxidative effects of the flavonoid. PMID:23736695

  14. Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans.

    PubMed

    Dillon, James; Holden-Dye, Lindy; O'Connor, Vincent; Hopper, Neil A

    2016-06-01

    Insulin signalling plays a significant role in both developmental programmes and pathways modulating the neuronal signalling that controls adult behaviour. Here, we have investigated insulin signalling in food-associated behaviour in adult C. elegans by scoring locomotion and feeding on and off bacteria, the worm's food. This analysis used mutants (daf-2, daf-18) of the insulin signalling pathway, and we provide evidence for an acute role for insulin signalling in the adult nervous system distinct from its impact on developmental programmes. Insulin receptor daf-2 mutants move slower than wild type both on and off food and showed impaired locomotory responses to food deprivation. This latter behaviour is manifest as a failure to instigate dispersal following prolonged food deprivation and suggests a role for insulin signalling in this adaptive response. Insulin receptor daf-2 mutants are also deficient in pharyngeal pumping on food and off food. Pharmacological analysis showed the pharynx of daf-2 is selectively compromised in its response to 5-HT compared to the excitatory neuropeptide FLP-17. By comparing the adaptive pharyngeal behaviour in intact worms and isolated pharyngeal preparations, we determined that an insulin-dependent signal extrinsic to the pharyngeal system is involved in feeding adaptation. Hence, we suggest that reactive insulin signalling modulates both locomotory foraging and pharyngeal pumping as the animal adapts to the absence of food. We discuss this in the context of insulin signalling directing a shift in the sensitivity of neurotransmitter systems to regulate the worm's response to changes in food availability in the environment.

  15. C. elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity

    PubMed Central

    Zhang, Yanmei; Xu, Jinling; Puscau, Cristina; Kim, Yongsoon; Wang, Xi; Alam, Hena; Hu, Patrick J.

    2008-01-01

    SUMMARY Insulin regulates development, metabolism, and lifespan via a conserved PI3K/Akt pathway that promotes cytoplasmic sequestration of FoxO transcription factors. The regulation of nuclear FoxO is poorly understood. In the nematode Caenorhabditis elegans, insulin-like signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifespan. In a screen for genes that modulate C. elegans insulin-like signaling, we identified eak-3, which encodes a novel protein that is specifically expressed in the two endocrine XXX cells. The dauer arrest phenotype of eak-3 mutants is fully suppressed by mutations in daf-16/FoxO, which encodes the major target of C. elegans insulin-like signaling, and daf-12, which encodes a nuclear receptor regulated by steroid hormones known as dafachronic acids. eak-3 mutation does not affect DAF-16/FoxO subcellular localization but enhances expression of the direct DAF-16/FoxO target sod-3 in a daf-16/FoxO- and daf-12-dependent manner. eak-3 mutants have normal lifespans, suggesting that EAK-3 decouples insulin-like regulation of development and longevity. We propose that EAK-3 activity in the XXX cells promotes the synthesis and/or secretion of a hormone that acts in parallel to AKT-1 to inhibit the expression of DAF-16/FoxO target genes. Similar hormonal pathways may regulate FoxO target gene expression in mammals. PMID:18241854

  16. Air

    MedlinePlus

    ... do to protect yourself from dirty air . Indoor air pollution and outdoor air pollution Air can be polluted indoors and it can ... this chart to see what things cause indoor air pollution and what things cause outdoor air pollution! Indoor ...

  17. Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging.

    PubMed

    Broillet, M; Randin, O; Chatton, J

    2001-03-02

    The fluorescent indicator of nitric oxide (NO), 4,5-diaminofluorescein (DAF-2), and its membrane-permeable derivative (DAF-2 diacetate) have been recently developed to perform real-time biological imaging of NO. In this study, we show that DAF-2 is strongly influenced by factors other than the concentration of NO itself. Using measurements with a fluorimeter as well as fluorescence microscopy, we found that the divalent cation concentration in the medium, as well as the incident light, strongly affects the ability of DAF-2 to detect NO. Calcium, in particular, enhanced the signal detection of NO released by NO donors by up to 200 times. With multiple and longer exposures to light, no bleaching of the dye was observed but, instead, a potentiation of the fluorescence response could be measured. While these two properties will affect the use and interpretation of the hitherto acquired data with this fluorescent compound, they may also open up new possibilities for its application.

  18. Adapting the Dynamic Allocation of Fires and Sensors (DAFS) Model for Use in Maritime Combat Analysis

    DTIC Science & Technology

    2008-03-01

    Helicopters 4 SH - 60F (logistics helo) 3 HH-60H (SAR helo) Not implemented 108 2. TICONDEROGA CLASS CRUISER (CG) Characteristic Jane’s Listing DAFS...IIA ARLEIGH BURKE class destroyers, and 4 SH -60R LAMPS helicopters launched from the cruisers and Flight IIA destroyers . The names of the vessels...DAFSRadarSensor Implemented as DAFSSensor Implemented as DAFSSensor Helicopters 2 SH -60B LAMPS Implemented as SH -60R LAMPS 109 3. ARLEIGH BURKE CLASS

  19. Regulation of lead toxicity by heat shock protein 90 (daf-21) is affected by temperature in Caenorhabditis elegans.

    PubMed

    Wang, Yunbiao; Xu, Songbai; Liu, Jing; Zhang, Yanhui; Guo, Tai L

    2014-06-01

    In the nematode Caenorhabditis elegans, stress resistance can be regulated by dauer formation (daf) genes. In the present study, regulation of heavy metal lead (Pb) toxicity by the 90-kDa heat shock proteins (Hsp90; daf-21) was investigated in both wild-type C. elegans and daf-21/Hsp90 mutants by focusing on the effects of varied temperatures below (15°C) or above (25 and 30°C) the presumptive optimum growth temperature (20°C). More acute toxicity of Pb, indicated by the 24-h median lethal concentrations (LC50), was observed in wild-type adults than in the daf-21 mutant adults at 15, 20 and 25°C; however, the daf-21 mutant adults showed more sensitivity at 30°C. Enhanced Pb sensitivity (e.g., decrease LC50) in both types of C. elegans was observed with both increased and decreased temperatures when compared to that at 20°C. Additional examined endpoints included time course of toxicity at LC50s, pharyngeal pumping, reproduction, life span, and Hsp90 expression. Collective results showed that temperatures both above and below 20°C exacerbated Pb toxicity, and that the protein level of daf-21/Hsp90 was one of the most sensitive indicators of Pb toxicity in wild-type C. elegans, while pharyngeal pumping was more Pb sensitive in daf-21 mutants. Therefore, the expression of daf-21/Hsp90 has apparent utility for the prediction and assessment of Pb-induced toxicity in nematodes. Further, the stress responses related to Hsp90 expression in C. elegans may have considerable potential as sensitive biomarkers for the monitoring of environmental Pb contamination.

  20. The DAF-7 TGF-β signaling pathway regulates chemosensory receptor gene expression in C. elegans

    PubMed Central

    Nolan, Katherine M.; Sarafi-Reinach, Trina R.; Horne, Jennifer G.; Saffer, Adam M.; Sengupta, Piali

    2002-01-01

    Regulation of chemoreceptor gene expression in response to environmental or developmental cues provides a mechanism by which animals can alter their sensory responses. Here we demonstrate a role for the daf-7 TGF-β pathway in the regulation of expression of a subset of chemoreceptor genes in Caenorhabditis elegans. We describe a novel role of this pathway in maintaining receptor gene expression in the adult and show that the DAF-4 type II TGF-β receptor functions cell-autonomously to modulate chemoreceptor expression. We also find that the alteration of receptor gene expression in the ASI chemosensory neurons by environmental signals, such as levels of a constitutively produced pheromone, may be mediated via a DAF-7-independent pathway. Receptor gene expression in the ASI and ASH sensory neurons appears to be regulated via distinct mechanisms. Our results suggest that the expression of individual chemoreceptor genes in C. elegans is subject to multiple modes of regulation, thereby ensuring that animals exhibit the responses most appropriate for their developmental stage and environmental conditions. PMID:12464635

  1. Isoamyl alcohol odor promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans.

    PubMed

    Kurino, Chiho; Furuhashi, Tsubasa; Sudoh, Kaori; Sakamoto, Kazuichi

    2017-02-14

    The possibility that odor plays a role in lifespan regulation through effects on the nervous system is indicated by research on Caenorhabditis elegans. In fact, ablation of AWA and AWC, which are suggested as olfactory neurons, has been shown to extend lifespan via DAF-16, a homolog of FoxO. However, the effects of odor stimuli on the lifespan still remain unclear. Thus, we here aimed to clarify the effect of attractive and repulsive odors on longevity and stress tolerance in C. elegans and to analyze the pathways thereof. We used isoamyl alcohol as an attractive odor, and acetic acid as a repellent component, as identified by chemotaxis assay. We found that isoamyl alcohol stimulus promoted longevity in a DAF-16-dependent manner. On the other hand, acetic acid stimulus promoted thermotolerance through mechanisms independent of DAF-16. Above all, our results indicate that odor stimuli affect the lifespan and stress tolerance of C. elegans, with attractive and repulsive odors exerting their effects through different mechanisms, and that longevity is induced by both activation and inactivation of olfactory neurons.

  2. DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

    PubMed Central

    Babu, Vipin; Ermolaeva, Maria A.; Müller, Roman-Ulrich; Frommolt, Peter; Williams, Ashley B.; Greiss, Sebastian; Schneider, Jennifer I.; Benzing, Thomas; Schermer, Bernhard; Schumacher, Björn

    2014-01-01

    Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility, and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates with aging. Here we show that the FoxO transcription factor DAF-16 is activated in response to DNA damage during development while the DNA damage responsiveness of DAF-16 declines with aging. We find that in contrast to its established role in mediating starvation arrest, DAF-16 alleviates DNA damage-induced developmental arrest and even in the absence of DNA repair promotes developmental growth and enhances somatic tissue functionality. We demonstrate that the GATA transcription factor EGL-27 co-regulates DAF-16 target genes in response to DNA damage and together with DAF-16 promotes developmental growth. We propose that EGL-27/GATA activity specifies DAF-16 mediated DNA damage responses to enable developmental progression and to prolong tissue functioning when DNA damage persists. PMID:25419847

  3. Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies

    PubMed Central

    Bulger, David A.; Fukushige, Tetsunari; Yun, Sijung; Semple, Robert K.; Hanover, John A.; Krause, Michael W.

    2016-01-01

    Human exome sequencing has dramatically increased the rate of identification of disease-associated polymorphisms. However, examining the functional consequences of those variants has created an analytic bottleneck. Insulin-like signaling in Caenorhabditis elegans has long provided a model to assess consequences of human insulin signaling mutations, but this has not been evaluated in the context of current genetic tools. We have exploited strains derived from the Million Mutation Project (MMP) and gene editing to explore further the evolutionary relationships and conservation between the human and C. elegans insulin receptors. Of 40 MMP alleles analyzed in the C. elegans insulin-like receptor gene DAF-2, 35 exhibited insulin-like signaling indistinguishable from wild-type animals, indicating tolerated mutations. Five MMP alleles proved to be novel dauer-enhancing mutations, including one new allele in the previously uncharacterized C-terminus of DAF-2. CRISPR-Cas9 genome editing was used to confirm the phenotypic consequence of six of these DAF-2 mutations and to replicate an allelic series of known human disease mutations in a highly conserved tyrosine kinase active site residue, demonstrating the utility of C. elegans for directly modeling human disease. Our results illustrate the challenges associated with prediction of the phenotypic consequences of amino acid substitutions, the value of assaying mutant isoform function in vivo, and how recently developed tools and resources afford the opportunity to expand our understanding even of highly conserved regulatory modules such as insulin signaling. This approach may prove generally useful for modeling phenotypic consequences of candidate human pathogenic mutations in conserved signaling and developmental pathways. PMID:27856697

  4. DAF-16/FOXO regulates homeostasis of essential sleep-like behavior during larval transitions in C. elegans.

    PubMed

    Driver, Robert J; Lamb, Annesia L; Wyner, Abraham J; Raizen, David M

    2013-03-18

    Sleep homeostasis, which refers to the maintenance of sleep amount or depth following sleep deprivation, indicates that sleep and sleep-like states serve fundamental functions that cannot be bypassed [1]. Homeostasis of sleep-like behavior is observed during C. elegans lethargus, a 2-3 hr behavioral quiescent period that occurs during larval state transitions [2]. Here, we report a role for DAF-16/FOXO, a transcription factor that is active under conditions of stress [3], in the response to deprivation of lethargus quiescence. Forced locomotion during lethargus results in nuclear translocation of DAF-16. The formation of dauer larvae, a developmental state promoted by daf-16, is increased in response to quiescence deprivation. daf-16 mutants show an impaired homeostatic response to deprivation of lethargus quiescence and are hypersensitive to the lethal effects of forced locomotion during lethargus. DAF-16 expression in muscle cells, but not in neurons, is sufficient to restore a homeostatic response to deprivation of quiescence, pointing to a role for muscle in sleep homeostasis. These findings are relevant to clinical observations of altered metabolic signaling in response to sleep deprivation and suggest that these signaling pathways may act in nonneuronal tissue to regulate sleep behaviors.

  5. Baseline tests of the C. H. Waterman DAF electric passenger vehicle

    NASA Technical Reports Server (NTRS)

    Sargent, N. B.; Maslowski, E. A.; Soltis, R. F.; Schuh, R. M.

    1977-01-01

    An electric vehicle was tested as part of an Energy Research Development Administration (ERDA) project to characterize the state-of-the-art of electric vehicles. The Waterman vehicle performance test results are presented in this report. The vehicle is a converted four-passenger DAF 46 sedan. It is powered by sixteen 6-volt traction batteries through a three-step contactor controller actuated by a foot throttle to change the voltage applied to the 6.7 kW motor. The braking system is a conventional hydraulic braking system.

  6. The Thioredoxin TRX-1 Modulates the Function of the Insulin-Like Neuropeptide DAF-28 during Dauer Formation in Caenorhabditis elegans

    PubMed Central

    Fierro-González, Juan Carlos; Cornils, Astrid; Alcedo, Joy

    2011-01-01

    Thioredoxins comprise a conserved family of redox regulators involved in many biological processes, including stress resistance and aging. We report that the C. elegans thioredoxin TRX-1 acts in ASJ head sensory neurons as a novel modulator of the insulin-like neuropeptide DAF-28 during dauer formation. We show that increased formation of stress-resistant, long-lived dauer larvae in mutants for the gene encoding the insulin-like neuropeptide DAF-28 requires TRX-1 acting in ASJ neurons, upstream of the insulin-like receptor DAF-2. Genetic rescue experiments demonstrate that redox-independent functions of TRX-1 specifically in ASJ neurons are needed for the dauer formation constitutive (Daf-c) phenotype of daf-28 mutants. GFP reporters of trx-1 and daf-28 show opposing expression patterns in dauers (i.e. trx-1 is up-regulated and daf-28 is down-regulated), an effect that is not observed in growing L2/L3 larvae. In addition, functional TRX-1 is required for the down-regulation of a GFP reporter of daf-28 during dauer formation, a process that is likely subject to DAF-28-mediated feedback regulation. Our findings demonstrate that TRX-1 modulates DAF-28 signaling by contributing to the down-regulation of daf-28 expression during dauer formation. We propose that TRX-1 acts as a fluctuating neuronal signaling modulator within ASJ neurons to monitor the adjustment of neuropeptide expression, including insulin-like proteins, during dauer formation in response to adverse environmental conditions. PMID:21304598

  7. Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation

    PubMed Central

    Lavitrano, Marialuisa; Bacci, Maria Laura; Forni, Monica; Lazzereschi, Davide; Di Stefano, Carla; Fioretti, Daniela; Giancotti, Paola; Marfé, Gabriella; Pucci, Loredana; Renzi, Luigina; Wang, Hongjun; Stoppacciaro, Antonella; Stassi, Giorgio; Sargiacomo, Massimo; Sinibaldi, Paola; Turchi, Valeria; Giovannoni, Roberto; Della Casa, Giacinto; Seren, Eraldo; Rossi, Giancarlo

    2002-01-01

    A large number of hDAF transgenic pigs to be used for xenotransplantation research were generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis obtained with SMGT was much greater than with any other method. In the experiments reported, up to 80% of pigs had the transgene integrated into the genome. Most of the pigs carrying the hDAF gene transcribed it in a stable manner (64%). The great majority of pigs that transcribed the gene expressed the protein (83%). The hDAF gene was transmitted to progeny. Expression was stable and found in caveolae as it is in human cells. The expressed gene was functional based on in vitro experiments performed on peripheral blood mononuclear cells. These results show that our SMGT approach to transgenesis provides an efficient procedure for studies involving large animal models. PMID:12393815

  8. Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells

    PubMed Central

    Qin, Zhao; Hubbard, E. Jane Albert

    2015-01-01

    Stem cells maintain tissues and organs over the lifespan of individuals. How aging influences this process is unclear. Here we investigate the effects of aging on C. elegans germline stem/progenitor cells and show that the progenitor pool is depleted over time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS). Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is required for germline progenitor maintenance, and that this role is separable from the effect of DAF-16/FOXO on organismal aging. In addition, blocking germ cell flux, similar to reducing IIS, maintains germline progenitors. This effect is partially dependent on gonadal DAF-16/FOXO activity. Our results imply that (1) longevity pathways can regulate aging stem cells through anatomically separable mechanisms, (2) stem cell maintenance is not necessarily prioritized and (3) stem cell regulation can occur at the level of an entire organ system such as the reproductive system. PMID:25960195

  9. DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis.

    PubMed

    Lopez, Andrew L; Chen, Jessica; Joo, Hyoe-Jin; Drake, Melanie; Shidate, Miri; Kseib, Cedric; Arur, Swathi

    2013-10-28

    Coupling the production of mature gametes and fertilized zygotes to favorable nutritional conditions improves reproductive success. In invertebrates, the proliferation of female germline stem cells is regulated by nutritional status. However, in mammals, the number of female germline stem cells is set early in development, with oocytes progressing through meiosis later in life. Mechanisms that couple later steps of oogenesis to environmental conditions remain largely undefined. We show that, in the presence of food, the DAF-2 insulin-like receptor signals through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the absence of food, the resultant inactivation of insulin-like signaling leads to downregulation of the RAS-ERK pathway, and oogenesis is stalled. Thus, the insulin-like signaling pathway couples nutrient sensing to meiotic I progression and oocyte production in C. elegans, ensuring that oocytes are only produced under conditions favorable for the survival of the resulting zygotes.

  10. Development of a recombinant CHO cell model for the investigation of CAR and DAF role during early steps of echovirus 6 infection.

    PubMed

    Renois, Fanny; Hong, Saw-See; Le Naour, Richard; Gafa, Valérie; Talmud, Déborah; Andréoletti, Laurent; Lévêque, Nicolas

    2011-06-01

    The early steps of echovirus 6 (E6) infection remain poorly understood and the only described receptor for haemagglutinating E6 strains is the decay accelerating factor (DAF). There is, however, accumulating evidence suggesting that E6 interaction with DAF is necessary but not sufficient for infection. In this report, we investigated the role of the coxsackie-adenovirus-receptor (CAR) as a potential DAF co-receptor during E6 infection. Using stably transfected Chinese Hamster Ovary (CHO) cells expressing CAR and DAF receptors, we found that DAF expression allowed attachment of both haemagglutinating and non-haemagglutinating E6 strains but was not sufficient for promoting E6 cell entry. Interestingly, the co-expression of DAF and CAR rendered 0.1-0.2% of cells permissive to some E6 strains' infection. Although our results did not show a major role of the CAR/DAF cooperation for E6 infection, it nevertheless indicated the use of CAR in the cell entry step of some minor E6 quasispecies. Moreover, the present report validates the use of recombinant CHO cells as valuable cellular model for the further characterisation of E6 receptors.

  11. PROTECTIVE EFFECT OF ScFv-DAF FUSION PROTEIN ON THE COMPLEMENT ATTACK TO ACETYLCHOLINE RECEPTOR: A POSSIBLE OPTION FOR TREATMENT OF MYASTHENIA GRAVIS

    PubMed Central

    XU, JIANG; WU, XINGAN; ZHANG, FANGLIN; LIN, HONG; LI, ZHUYI; KAMINSKI, HENRY J.

    2015-01-01

    Introduction Autoantibody-induced complement activation, which causes disruption of the postsynaptic membrane, is recognized as a key pathogenic factor in myasthenia gravis (MG). Therefore, specific targeting of complement inhibitors to the site of complement activation is a potential therapeutic strategy for treatment of MG. Methods We assessed expression of single-chain antibody fragment–decay accelerating factor (scFv-DAF), comprising a single-chain fragment scFv1956 based on the rat complement inhibitor DAF in prokaryotic systems, and studied its inhibitory effect on complement deposition in vitro. Results The recombinant conjugate scFv-DAF completely retained the wild-type binding activity of scFv1956 to AChR and inhibited complement activation of DAF in vitro. Conclusions We found that scFv-DAF could bind specifically to TE671 cells, and it is significantly more potent at inhibiting complement deposition than the untargeted parent molecule DAF. scFv-DAF may be a candidate for in vivo protection of the AChR in MG. PMID:22499093

  12. Effects of non-latching blast valves on the source term and consequences of the design-basis accidents in the Device Assembly Facility (DAF)

    SciTech Connect

    Nguyen, D.H.

    1993-08-01

    The analysis of the Design-Basis Accidents (DBA) involving high explosives (HE) and Plutonium (Pu) in the assembly cell of the Device Assembly Facility (DAF), which was completed earlier, assumed latching blast valves in the ventilation system of the assembly cell. Latching valves effectively sealed a release path through the ventilation duct system. However, the blast valves in the assembly cell, as constructed are actually non-latching valves, and would reopen when the gas pressure drops to 0.5 psi above one atmosphere. Because the reopening of the blast valves provides an additional release path to the environment, and affects the material transport from the assembly cell to other DAF buildings, the DOE/NV DAF management has decided to support an additional analysis of the DAF`s DBA to account for the effects of non-latching valves. Three cases were considered in the DAF`s DBA, depending on the amount of HE and Pu involved, as follows: Case 1 -- 423 {number_sign}HE, 16 kg Pu; Case 2 -- 150 {number_sign}HE 10 kg Pu; Case 3 -- 55 {number_sign}HE 5 kg Pu. The results of the analysis with non-latching valves are summarized.

  13. DAF: differential ACE filtering image quality assessment by automatic color equalization

    NASA Astrophysics Data System (ADS)

    Ouni, S.; Chambah, M.; Saint-Jean, C.; Rizzi, A.

    2008-01-01

    Ideally, a quality assessment system would perceive and measure image or video impairments just like a human being. But in reality, objective quality metrics do not necessarily correlate well with perceived quality [1]. Plus, some measures assume that there exists a reference in the form of an "original" to compare to, which prevents their usage in digital restoration field, where often there is no reference to compare to. That is why subjective evaluation is the most used and most efficient approach up to now. But subjective assessment is expensive, time consuming and does not respond, hence, to the economic requirements [2,3]. Thus, reliable automatic methods for visual quality assessment are needed in the field of digital film restoration. The ACE method, for Automatic Color Equalization [4,6], is an algorithm for digital images unsupervised enhancement. It is based on a new computational approach that tries to model the perceptual response of our vision system merging the Gray World and White Patch equalization mechanisms in a global and local way. Like our vision system ACE is able to adapt to widely varying lighting conditions, and to extract visual information from the environment efficaciously. Moreover ACE can be run in an unsupervised manner. Hence it is very useful as a digital film restoration tool since no a priori information is available. In this paper we deepen the investigation of using the ACE algorithm as a basis for a reference free image quality evaluation. This new metric called DAF for Differential ACE Filtering [7] is an objective quality measure that can be used in several image restoration and image quality assessment systems. In this paper, we compare on different image databases, the results obtained with DAF and with some subjective image quality assessments (Mean Opinion Score MOS as measure of perceived image quality). We study also the correlation between objective measure and MOS. In our experiments, we have used for the first image

  14. FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

    SciTech Connect

    Dhondt, Ineke; Petyuk, Vladislav A.; Cai, Huaihan; Vandemeulebroucke, Lieselot; Vierstraete, Andy; Smith, Richard D.; Depuydt, Geert; Braeckman, Bart  P.

    2016-09-13

    Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. But, lowering translational efficiency extends rather than shortens the lifespan in C. elegans. We studied turnover of individual proteins in the long-lived daf-2 mutant by combining SILeNCe (stable isotope labeling by nitrogen in Caenorhabditiselegans) and mass spectrometry. Intriguingly, the majority of proteins displayed prolonged half-lives in daf-2, whereas others remained unchanged, signifying that longevity is not supported by high protein turnover. We found that this slowdown was most prominent for translation-related and mitochondrial proteins. Conversely, the high turnover of lysosomal hydrolases and very low turnover of cytoskeletal proteins remained largely unchanged. The slowdown of protein dynamics and decreased abundance of the translational machinery may point to the importance of anabolic attenuation in lifespan extension, as suggested by the hyperfunction theory.

  15. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.

    PubMed

    Wang, Xiaoxia; Cao, Min; Dong, Yuqing

    2016-08-23

    Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders.

  16. Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16/FOXO

    PubMed Central

    2017-01-01

    Objective. Gengnianchun (GNC), a traditional Chinese medicine (TCM), is primarily used to improve declining functions related to aging. In this study, we investigated its prolongevity and stress resistance properties and explored the associated regulatory mechanism using a Caenorhabditis elegans model. Methods. Wild-type C. elegans N2 was used for lifespan analysis and oxidative stress resistance assays. Transgenic animals were used to investigate pathways associated with antioxidative stress activity. The effects of GNC on levels of reactive oxygen species (ROS) and expression of specific genes were examined. Results. GNC-treated wild-type worms showed an increase in survival time under both normal and oxidative stress conditions. GNC decreased intracellular ROS levels by 67.95%. GNC significantly enhanced the oxidative stress resistance of several mutant strains, suggesting that the protective effect of GNC is independent of the function of these genes. However, the oxidative stress resistance effect of GNC was absent in worms with daf-16 mutation. We also found upregulation of daf-16 downstream targets including sod-3 and mtl-1. Conclusions. Our findings suggest that GNC extends the lifespan of C. elegans and enhances its resistance to oxidative stress via a daf-16/FOXO-dependent pathway. This study also provides a feasible method for screening the biological mechanisms of TCMs.

  17. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.

    PubMed

    Ding, Ai-Jun; Wu, Gui-Sheng; Tang, Bin; Hong, Xuechuan; Zhu, Michael X; Luo, Huai-Rong

    2017-02-01

    With the growth of aging population, there is increasing demand to develop strategy to improve the aging process and aging-related diseases. Benzimidazole and its derivatives are crucial heterocyclic backbone of many drugs and compounds with diverse therapeutic applications, including alleviation of aging-related diseases. Here, we investigate if the benzimidazole derivative n-butyl-[1H]-benzimidazol-2-amine (M084), a novel inhibitor of TRPC4 and TRPC5 channels and antidepressant, could affect the lifespan of Caenorhabditis elegans (C. elegans). Our results showed that M084 could extend the lifespan of C. elegans, delay age-related decline of phenotypes, and improve stress resistance. M084 could not extend the lifespan of the loss-of-function mutants of daf-16, daf-2, pdk-1, aak-2, clk-1, isp-1, sir-2.1, and skn-1. M084 could decrease the ATP level and increase the gene expression of mitochondrial unfolded protein response factors. Thus, M084 might inhibit the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruite SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delay the aging process of C. elegans. Our findings reveal the new pharmaceutical potential of benzimidazole derivatives and provide clue for developing novel anti-aging agents.

  18. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

    PubMed

    Robida-Stubbs, Stacey; Glover-Cutter, Kira; Lamming, Dudley W; Mizunuma, Masaki; Narasimhan, Sri Devi; Neumann-Haefelin, Elke; Sabatini, David M; Blackwell, T Keith

    2012-05-02

    The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop. Rapamycin triggers a similar protective response in C. elegans and mice, but increases worm life span dependent upon SKN-1 and not DAF-16, apparently by interfering with TORC2 along with TORC1. TORC1, TORC2, and insulin/IGF-1-like signaling regulate SKN-1 activity through different mechanisms. We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity.

  19. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.

    PubMed

    Seo, Mihwa; Seo, Keunhee; Hwang, Wooseon; Koo, Hee Jung; Hahm, Jeong-Hoon; Yang, Jae-Seong; Han, Seong Kyu; Hwang, Daehee; Kim, Sanguk; Jang, Sung Key; Lee, Yoontae; Nam, Hong Gil; Lee, Seung-Jae V

    2015-08-04

    The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. We find that HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) and is sufficient for extending lifespan. We further show that the expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes. Thus, the RNA helicase HEL-1 appears to promote longevity in response to decreased IIS as a transcription coregulator of DAF-16. Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans.

  20. MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans.

    PubMed

    Isik, Meltem; Blackwell, T Keith; Berezikov, Eugene

    2016-12-01

    Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. Earlier studies demonstrated a central role for the miR-34 family in promoting cell cycle arrest and cell death following stress in human cells. However, the biological significance of this response was unclear. Here we show that in C. elegans mir-34 upregulation is necessary for developmental arrest, correct morphogenesis, and adaptation to a lower metabolic state to protect animals against stress-related damage. Either deletion or overexpression of mir-34 lead to an impaired stress response, which can largely be explained by perturbations in DAF-16/FOXO target gene expression. We demonstrate that mir-34 expression is regulated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO. We propose that mir-34 provides robustness to stress response programs by controlling noise in the DAF-16/FOXO-regulated gene network.

  1. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease

    PubMed Central

    Wang, Xiaoxia; Cao, Min; Dong, Yuqing

    2016-01-01

    Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders. PMID:27472466

  2. MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans

    PubMed Central

    Isik, Meltem; Blackwell, T. Keith; Berezikov, Eugene

    2016-01-01

    Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. Earlier studies demonstrated a central role for the miR-34 family in promoting cell cycle arrest and cell death following stress in human cells. However, the biological significance of this response was unclear. Here we show that in C. elegans mir-34 upregulation is necessary for developmental arrest, correct morphogenesis, and adaptation to a lower metabolic state to protect animals against stress-related damage. Either deletion or overexpression of mir-34 lead to an impaired stress response, which can largely be explained by perturbations in DAF-16/FOXO target gene expression. We demonstrate that mir-34 expression is regulated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO. We propose that mir-34 provides robustness to stress response programs by controlling noise in the DAF-16/FOXO-regulated gene network. PMID:27905558

  3. Gαo and Gαq Regulate the Expression of daf-7, a TGFβ-like Gene, in Caenorhabditis elegans

    PubMed Central

    Myers, Edith M.

    2012-01-01

    Caenorhabditis elegans enter an alternate developmental stage called dauer in unfavorable conditions such as starvation, overcrowding, or high temperature. Several evolutionarily conserved signaling pathways control dauer formation. DAF-7/TGFβ and serotonin, important ligands in these signaling pathways, affect not only dauer formation, but also the expression of one another. The heterotrimeric G proteins GOA-1 (Gαo) and EGL-30 (Gαq) mediate serotonin signaling as well as serotonin biosynthesis in C. elegans. It is not known whether GOA-1 or EGL-30 also affect dauer formation and/or daf-7 expression, which are both modulated in part by serotonin. The purpose of this study is to better understand the relationship between proteins important for neuronal signaling and developmental plasticity in both C. elegans and humans. Using promoter-GFP transgenic worms, it was determined that both goa-1 and egl-30 regulate daf-7 expression during larval development. In addition, the normal daf-7 response to high temperature or starvation was altered in goa-1 and egl-30 mutants. Despite the effect of goa-1 and egl-30 mutations on daf-7 expression in various environmental conditions, there was no effect of the mutations on dauer formation. This paper provides evidence that while goa-1 and egl-30 are important for normal daf-7 expression, mutations in these genes are not sufficient to disrupt dauer formation. PMID:22808145

  4. GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus.

    PubMed

    Das, U N

    1999-01-01

    It is now believed that the GLUT-4 receptor, tumor necrosis factor-alpha (TNF-alpha), essential fatty acids (EFAs) and their metabolites and daf-genes have an important role in the development of obesity and non-insulin dependent diabetes mellitus (NIDDM). The protein encoded by daf-2 is 35% identical to the human insulin receptor, daf-7 codes a transforming growth factor-beta (TGF-beta) type signal and daf-16 can enhance superoxide dismutase (SOD) expression. EFAs and their metabolites can alter the cell membrane fluidity and enhance the expression of GLUT-4 and insulin receptors. EFAs can suppress TNF-alpha production and secretion, a mechanism that may have relevance to the role of these fatty acids in the pathogenesis of insulin resistance, obesity and NIDDM. Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD. Based on this evidence, it is proposed that GLUT-4, TNF-alpha, EFAs, daf-genes, melatonin and leptin interact with each other in ways which may have relevance to the development or abrogation of insulin resistance, obesity, NIDDM, complications due to NIDDM, longevity and ageing.

  5. Dissolved air flotation primary clarifier improves performance of biological waste treatment at a latex manufacturing facility

    SciTech Connect

    Miller, D.R.; Kerecz, B.J.; Davis, M.N.

    1996-12-31

    Air Products and Chemicals, Inc. operates a chemical manufacturing facility in Piedmont, SC which generates a high strength COD emulsion wastewater from latex manufacturing. The on-site wastewater treatment facility consisted of flow equalization, activated sludge treatment and gravity clarification. The inability of the biological system to assimilate the high strength emulsion wastwater loadings led to incomplete conversion within the activated sludge process and poor settling waste sludge with turbid final effluent high in COD, BOD and TSS. The facility installed a dissolved air flotation (DAF) clarifier to effectively remove greater than 99 percent of the wastewater emulsion solids ahead of the activated sludge system. An organic coagulant is used for emulsion destabilization instead of iron or aluminum metal coagulants, improving DAF clarifier performance and minimizing operational cost and system complexity. An innovative DAF float solids collection and handling system produces disposal solids concentrations of 50 - 60% total solids resulting in further waste disposal cost savings. By removing more than 99 percent of the emulsion solids with the DAF clarifier ahead of the activated sludge process, the waste-water treatment facility now consistently produces a high quality effluent low in COD, BOD, TSS and turbidity. Wastewater treatment performance improved dramatically, as evident by the facility receiving the Western Carolina Regional Sewer Authority`s {open_quotes}Best Pollution Prevention Program{close_quotes} award. In addition, the wastewater treatment facility can now process three times the pre-DAF waste loads.

  6. The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

    PubMed Central

    Warnhoff, Kurt; Murphy, John T.; Kumar, Sandeep; Schneider, Daniel L.; Peterson, Michelle; Hsu, Simon; Guthrie, James; Robertson, J. David; Kornfeld, Kerry

    2014-01-01

    The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To identify genes that mediate stress resistance, we screened for C. elegans mutants that can tolerate high levels of dietary zinc. We identified natc-1, which encodes an evolutionarily conserved subunit of the N-terminal acetyltransferase C (NAT) complex. N-terminal acetylation is a widespread modification of eukaryotic proteins; however, relatively little is known about the biological functions of NATs. We demonstrated that loss-of-function mutations in natc-1 cause resistance to a broad-spectrum of physiologic stressors, including multiple metals, heat, and oxidation. The C. elegans FOXO transcription factor DAF-16 is a critical target of the insulin/IGF-1 signaling pathway that mediates stress resistance, and DAF-16 is predicted to directly bind the natc-1 promoter. To characterize the regulation of natc-1 by DAF-16 and the function of natc-1 in insulin/IGF-1 signaling, we analyzed molecular and genetic interactions with key components of the insulin/IGF-1 pathway. natc-1 mRNA levels were repressed by DAF-16 activity, indicating natc-1 is a physiological target of DAF-16. Genetic studies suggested that natc-1 functions downstream of daf-16 to mediate stress resistance and dauer formation. Based on these findings, we hypothesize that natc-1 is directly regulated by the DAF-16 transcription factor, and natc-1 is a physiologically significant effector of the insulin/IGF-1 signaling pathway that mediates stress resistance and dauer formation. These studies identify a novel biological function for natc-1 as a modulator of stress resistance and dauer formation and define a functionally significant downstream effector of the insulin/IGF-1 signaling pathway. Protein N-terminal acetylation mediated by the NatC complex may play an evolutionarily conserved role in regulating stress resistance. PMID:25330323

  7. PI3K/Akt pathway restricts epithelial adhesion of Dr+ Escherichia coli by down-regulating the expression of Decay Accelerating Factor (DAF)

    PubMed Central

    Banadakoppa, Manu; Goluszko, Pawel; Liebenthal, Daniel; Nowicki, Bogdan J.; Nowicki, Stella; Yallampalli, Chandra

    2014-01-01

    The urogenital microbial infection in pregnancy is an important cause of maternal and neonatal morbidity and mortality. Uropathogenic Escherichia coli strains which express Dr fimbriae (Dr+) are associated with unique gestational virulence and they utilize cell surface decay accelerating factor (DAF or CD55) as one of the cellular receptor before invading the epithelial cells. Previous studies in our laboratory established that nitric oxide reduces the rate of E. coli invasion by delocalizing the DAF protein from cell surface lipid rafts and down-regulating its expression. The phosphoinositide 3-kinase/ protein kinase B (PI3K/Akt) cell signal pathway plays an important role in host-microbe interaction because many bacteria including E. coli activate this pathway in order to establish infection. In the present study we showed that the PI3K/Akt pathway negatively regulates the expression of DAF on the epithelial cell surface and thus inhibits the adhesion of Dr+ E. coli to epithelial cells. Initially, using two human cell lines Ishikawa and HeLa which differ in constitutive activity of PI3K/Akt we showed that DAF levels were associated with the PI3K/Akt pathway. We then showed that the DAF gene expression was up-regulated and the Dr+ E. coli adhesion increased after the suppression of PI3K/Akt pathway in Ishikawa cells using inhibitor LY-294002, and a plasmid which allowed the expression of PI3K/Akt regulatory protein PTEN. The down-regulation of PTEN protein using PTEN-specific siRNA activated the PI3K/Akt pathway, down-regulated the DAF and decreased the adhesion of Dr+ E. coli. We conclude that the PI3K/Akt pathway regulated the DAF expression in a nitric oxide independent manner. PMID:24599886

  8. Ionic liquid foam floatation coupled with ionic liquid dispersive liquid-liquid microextraction for the separation and determination of estrogens in water samples by high-performance liquid chromatography with fluorescence detection.

    PubMed

    Zhang, Rui; Wang, Chuanliu; Yue, Qiaohong; Zhou, Tiecheng; Li, Na; Zhang, Hanqi; Hao, Xiaoke

    2014-11-01

    An ionic liquid foam floatation coupled with ionic liquid dispersive liquid-liquid microextraction method was proposed for the extraction and concentration of 17-α-estradiol, 17-β-estradiol-benzoate, and quinestrol in environmental water samples by high-performance liquid chromatography with fluorescence detection. 1-Hexyl-3-methylimidazolium tetrafluoroborate was applied as foaming agent in the foam flotation process and dispersive solvent in microextraction. The introduction of the ion-pairing and salting-out agent NH4 PF6 was beneficial to the improvement of recoveries for the hydrophobic ionic liquid phase and analytes. Parameters of the proposed method including concentration of 1-hexyl-3-methylimidazolium tetrafluoroborate, flow rate of carrier gas, floatation time, types and concentration of ionic liquids, salt concentration in samples, extraction time, and centrifugation time were evaluated. The recoveries were between 98 and 105% with relative standard deviations lower than 7% for lake water and well water samples. The isolation of the target compounds from the water was found to be efficient, and the enrichment factors ranged from 4445 to 4632. This developing method is free of volatile organic solvents compared with regular extraction. Based on the unique properties of ionic liquids, the application of foam floatation, and dispersive liquid-liquid microextraction was widened.

  9. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

    PubMed Central

    Son, Heehwa G.; Seo, Mihwa; Ham, Seokjin; Hwang, Wooseon; Lee, Dongyeop; An, Seon Woo A.; Artan, Murat; Seo, Keunhee; Kaletsky, Rachel; Arey, Rachel N.; Ryu, Youngjae; Ha, Chang Man; Kim, Yoon Ki; Murphy, Coleen T.; Roh, Tae-Young; Nam, Hong Gil; Lee, Seung-Jae V.

    2017-01-01

    Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations. PMID:28276441

  10. A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.

    PubMed

    Goszczynski, Barbara; Captan, Vasile V; Danielson, Alicia M; Lancaster, Brett R; McGhee, James D

    2016-05-01

    The Caenorhabditis elegans vitellogenin genes are transcribed in the intestine of adult hermaphrodites but not of males. A 44-bp region from the vit-2 gene promoter is able largely to reconstitute this tissue-, stage- and sex-specific-expression. This "enhancer" contains a binding site for the DM-domain factor MAB-3, the male-specific repressor of vitellogenesis, as well as an activator site that we show is the direct target of the intestinal GATA factor ELT-2. We further show that the enhancer is directly activated by the winged-helix/forkhead-factor FKH-9, (whose gene has been shown by others to be a direct target of DAF-16), by an unknown activator binding to the MAB-3 site, and by the full C. elegans TGF-β/Sma/Mab pathway acting within the intestine. The vit-2 gene has been shown by others to be repressed by the daf-2/daf-16 insulin signaling pathway, which so strongly influences aging and longevity in C. elegans. We show that the activity of the 44 bp vit-2 enhancer is abolished by loss of daf-2 but is restored by simultaneous loss of daf-16. DAF-2 acts from outside of the intestine but DAF-16 acts both from outside of the intestine and from within the intestine where it binds directly to the same non-canonical target site that interacts with FKH-9. Activity of the 44 bp vit-2 enhancer is also inhibited by loss of the germline, in a manner that is only weakly influenced by DAF-16 but that is strongly influenced by KRI-1, a key downstream effector in the pathway by which germline loss increases C. elegans lifespan. The complex behavior of this enhancer presumably allows vitellogenin gene transcription to adjust to demands of body size, germline proliferation and nutritional state but we suggest that the apparent involvement of this enhancer in aging and longevity "pathways" could be incidental.

  11. Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

    PubMed Central

    Przybysz, Aaron J.; Choe, Keith P.; Roberts, L. Jackson; Strange, Kevin

    2009-01-01

    Cells adapt to stressors by activating mechanisms that repair damage and protect them from further injury. Stress-induced damage accumulates with age and contributes to age associated diseases. Increased age attenuates the ability to mount a stress response, but little is known about the mechanisms by which this occurs. To begin addressing this problem, we studied hormesis in the nematode Caenorhabditis elegans. When exposed to a low concentration of the xenobiotic juglone, young worms mount a robust hormetic stress response and survive a subsequent exposure to a higher concentration of juglone that is normally lethal to naïve animals. Old worms are unable to mount this adaptive response. Microarray and RNAi analyses demonstrate that an altered transcriptional response to juglone is responsible in part for the reduced adaptation of old worms. Many genes differentially regulated in young versus old animals are known or postulated to be regulated by the FOXO homologue DAF-16 and the Nrf2 homologue SKN-1. Activation of these pathways is greatly reduced in juglone stressed old worms. DAF-16- and SKN-1-like transcription factors play highly conserved roles in regulating stress resistance and longevity genes. Our studies provide a foundation for developing a molecular understanding of how age affects cytoprotective transcriptional pathways. PMID:19428455

  12. LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis.

    PubMed

    Wang, Dan; Hou, Lei; Nakamura, Shuhei; Su, Ming; Li, Fang; Chen, Weiyang; Yan, Yizhen; Green, Christopher D; Chen, Di; Zhang, Hong; Antebi, Adam; Han, Jing-Dong J

    2017-02-01

    The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging.

  13. FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

    DOE PAGES

    Dhondt, Ineke; Petyuk, Vladislav A.; Cai, Huaihan; ...

    2016-09-13

    Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. But, lowering translational efficiency extends rather than shortens the lifespan in C. elegans. We studied turnover of individual proteins in the long-lived daf-2 mutant by combining SILeNCe (stable isotope labeling by nitrogen in Caenorhabditiselegans) and mass spectrometry. Intriguingly, the majority of proteins displayed prolonged half-lives in daf-2, whereas others remained unchanged, signifying that longevity is not supported by high protein turnover. We found that this slowdown wasmore » most prominent for translation-related and mitochondrial proteins. Conversely, the high turnover of lysosomal hydrolases and very low turnover of cytoskeletal proteins remained largely unchanged. The slowdown of protein dynamics and decreased abundance of the translational machinery may point to the importance of anabolic attenuation in lifespan extension, as suggested by the hyperfunction theory.« less

  14. The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1.

    PubMed

    Guha, Sujay; Cao, Min; Kane, Ryan M; Savino, Anthony M; Zou, Sige; Dong, Yuqing

    2013-10-01

    Nutraceuticals are known to have numerous health and disease preventing properties. Recent studies suggest that extracts containing cranberry may have anti-aging benefits. However, little is known about whether and how cranberry by itself promotes longevity and healthspan in any organism. Here we examined the effect of a cranberry only extract on lifespan and healthspan in Caenorhabditis elegans. Supplementation of the diet with cranberry extract (CBE) increased the lifespan in C. elegans in a concentration-dependent manner. Cranberry also increased tolerance of C. elegans to heat shock, but not to oxidative stress or ultraviolet irradiation. In addition, we tested the effect of cranberry on brood size and motility and found that cranberry did not influence these behaviors. Our mechanistic studies indicated that lifespan extension induced by CBE requires the insulin/IGF signaling pathway and DAF-16. We also found that cranberry promotes longevity through osmotic stress resistant-1 (OSR-1) and one of its downstream effectors, UNC-43, but not through SEK-1, a component of the p38 MAP kinase pathway. However, SIR-2.1 and JNK signaling pathways are not required for cranberry to promote longevity. Our findings suggest that cranberry supplementation confers increased longevity and stress resistance in C. elegans through pathways modulated by daf-16 and osr-1. This study reveals the anti-aging property of widely consumed cranberry and elucidates the underpinning mechanisms.

  15. The impacts of replacing air bubbles with microspheres for the clarification of algae from low cell-density culture.

    PubMed

    Ometto, Francesco; Pozza, Carlo; Whitton, Rachel; Smyth, Beatrice; Gonzalez Torres, Andrea; Henderson, Rita K; Jarvis, Peter; Jefferson, Bruce; Villa, Raffaella

    2014-04-15

    Dissolved Air Flotation (DAF) is a well-known coagulation-flotation system applied at large scale for microalgae harvesting. Compared to conventional harvesting technologies DAF allows high cell recovery at lower energy demand. By replacing microbubbles with microspheres, the innovative Ballasted Dissolved Air Flotation (BDAF) technique has been reported to achieve the same algae cell removal efficiency, while saving up to 80% of the energy required for the conventional DAF unit. Using three different algae cultures (Scenedesmus obliquus, Chlorella vulgaris and Arthrospira maxima), the present work investigated the practical, economic and environmental advantages of the BDAF system compared to the DAF system. 99% cells separation was achieved with both systems, nevertheless, the BDAF technology allowed up to 95% coagulant reduction depending on the algae species and the pH conditions adopted. In terms of floc structure and strength, the inclusion of microspheres in the algae floc generated a looser aggregate, showing a more compact structure within single cell alga, than large and filamentous cells. Overall, BDAF appeared to be a more reliable and sustainable harvesting system than DAF, as it allowed equal cells recovery reducing energy inputs, coagulant demand and carbon emissions.

  16. Components of the Cultivated Red Seaweed Chondrus crispus Enhance the Immune Response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 Pathways

    PubMed Central

    Liu, Jinghua; Hafting, Jeff; Critchley, Alan T.; Banskota, Arjun H.

    2013-01-01

    Marine macroalgae are rich in bioactive compounds that can, when consumed, impart beneficial effects on animal and human health. The red seaweed Chondrus crispus has been reported to have a wide range of health-promoting activities, such as antitumor and antiviral activities. Using a Caenorhabditis elegans infection model, we show that C. crispus water extract (CCWE) enhances host immunity and suppresses the expression of quorum sensing (QS) and the virulence factors of Pseudomonas aeruginosa (strain PA14). Supplementation of nematode growth medium with CCWE induced the expression of C. elegans innate immune genes, such as irg-1, irg-2, F49F1.6, hsf-1, K05D8.5, F56D6.2, C29F3.7, F28D1.3, F38A1.5 ZK6.7, lys-1, spp-1, and abf-1, by more than 2-fold, while T20G5.7 was not affected. Additionally, CCWE suppressed the expression of PA14 QS genes and virulence factors, although it did not affect the growth of the bacteria. These effects correlated with a 28% reduction in the PA14-inflicted killing of C. elegans. Kappa-carrageenan (K-CGN), a major component of CCWE, was shown to play an important role in the enhancement of host immunity. Using C. elegans mutants, we identified that pmk-1, daf-2/daf-16, and skn-1 are essential in the K-CGN-induced host immune response. In view of the conservation of innate immune pathways between C. elegans and humans, the results of this study suggest that water-soluble components of C. crispus may also play a health-promoting role in higher animals and humans. PMID:24056462

  17. Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo

    PubMed Central

    Seregin, Sergey S.; Aldhamen, Yasser A.; Appledorn, Daniel M.; Hartman, Zachary C.; Schuldt, Nathaniel J.; Scott, Jeannine; Godbehere, Sarah; Jiang, Haixiang; Frank, Michael M.

    2010-01-01

    Adenovirus (Ad) vectors are widely used in human clinical trials. However, at higher dosages, Ad vector–triggered innate toxicities remain a major obstacle to many applications. Ad interactions with the complement system significantly contribute to innate immune responses in several models of Ad-mediated gene transfer. We constructed a novel class of Ad vectors, genetically engineered to “capsid-display” native and retro-oriented versions of the human complement inhibitor decay-accelerating factor (DAF), as a fusion protein from the C-terminus of the Ad capsid protein IX. In contrast to conventional Ad vectors, DAF-displaying Ads dramatically minimized complement activation in vitro and complement-dependent immune responses in vivo. DAF-displaying Ads did not trigger thrombocytopenia, minimized endothelial cell activation, and had diminished inductions of proinflammatory cytokine and chemokine responses. The retro-oriented display of DAF facilitated the greatest improvements in vivo, with diminished activation of innate immune cells, such as dendritic and natural killer cells. In conclusion, Ad vectors can capsid-display proteins in a manner that not only retains the functionality of the displayed proteins but also potentially can be harnessed to improve the efficacy of this important gene transfer platform for numerous gene transfer applications. PMID:20511542

  18. LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

    PubMed Central

    2015-01-01

    The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression in response to reduced insulin/IGF-1 signaling, including the expression levels of metabolism-associated genes. Taking advantage of the recent developments in quantitative liquid chromatography mass spectrometry (LC–MS)-based proteomics, we profiled the proteomic changes that occur in response to activation of the DAF-16 transcription factor in the germline-less glp-4(bn2);daf-2(e1370) receptor mutant. Strikingly, the daf-2 profile suggests extensive reorganization of intermediary metabolism, characterized by the upregulation of many core intermediary metabolic pathways. These include glycolysis/gluconeogenesis, glycogenesis, pentose phosphate cycle, citric acid cycle, glyoxylate shunt, fatty acid β-oxidation, one-carbon metabolism, propionate and tyrosine catabolism, and complexes I, II, III, and V of the electron transport chain. Interestingly, we found simultaneous activation of reciprocally regulated metabolic pathways, which is indicative of spatiotemporal coordination of energy metabolism and/or extensive post-translational regulation of these enzymes. This restructuring of daf-2 metabolism is reminiscent to that of hypometabolic dauers, allowing the efficient and economical utilization of internal nutrient reserves and possibly also shunting metabolites through alternative energy-generating pathways to sustain longevity. PMID:24555535

  19. LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

    SciTech Connect

    Depuydt, Geert; Xie, Fang; Petyuk, Vladislav A.; Smolders, Arne; Brewer, Heather M.; Camp, David G.; Smith, Richard D.; Braeckman, Bart P.

    2014-04-04

    The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression in response to reduced insulin/IGF-1 signaling, including the expression levels of metabolism-associated genes. Taking advantage of the recent developments in quantitative liquid chromatography mass spectrometry (LC–MS)-based proteomics, we profiled the proteomic changes that occur in response to activation of the DAF-16 transcription factor in the germline-less glp-4(bn2);daf-2(e1370) receptor mutant. Strikingly, the daf-2 profile suggests extensive reorganization of intermediary metabolism, characterized by the upregulation of many core intermediary metabolic pathways. These include glycolysis/gluconeogenesis, glycogenesis, pentose phosphate cycle, citric acid cycle, glyoxylate shunt, fatty acid β-oxidation, one-carbon metabolism, propionate and tyrosine catabolism, and complexes I, II, III, and V of the electron transport chain. Interestingly, we found simultaneous activation of reciprocally regulated metabolic pathways, which is indicative of spatiotemporal coordination of energy metabolism and/or extensive post-translational regulation of these enzymes. Finally, this restructuring of daf-2 metabolism is reminiscent to that of hypometabolic dauers, allowing the efficient and economical utilization of internal nutrient reserves and possibly also shunting metabolites through alternative energy-generating pathways to sustain longevity.

  20. LC-MS Proteomics Analysis of the Insulin/IGF-1 Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

    SciTech Connect

    Depuydt, Geert G.; Xie, Fang; Petyuk, Vladislav A.; Smolders, Arne; Brewer, Heather M.; Camp, David G.; Smith, Richard D.; Braeckman, Bart P.

    2014-02-20

    The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity and metabolism in C. elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression in response to reduced insulin/IGF-1 signaling, including expression levels of metabolism-associated genes. Taking advantage of the recent developments in quantitative liquid chromatography mass-spectrometry (LC-MS) based proteomics, we profiled the proteomic changes that occur in response to activation of the DAF-16 transcription factor in the germline-less glp-4(bn2); daf-2(e1370) receptor mutant. Strikingly, the daf-2 profile suggests extensive reorganization of intermediary metabolism, characterized by the up-regulation of many core intermediary metabolic pathways. These include, glycolysis/gluconeogenesis, glycogenesis, pentose phosphate cycle, citric acid cycle, glyoxylate shunt, fatty acid β-oxidation, one-carbon metabolism, propionate and tyrosine catabolism, and complex I, II, III and V of the electron transport chain. Interestingly, we found simultaneous activation of reciprocally regulated metabolic pathways, which is indicative for spatio-temporal coordination of energy metabolism and/or extensive post-translational regulation of these enzymes. This restructuring of daf-2 metabolism is reminiscent to that of hypometabolic dauers, allowing the efficient and economical utilization of internal nutrient reserves, possibly also shunting metabolites through alternative energy-generating pathways, in order to sustain longevity.

  1. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.

    PubMed

    Hammell, Christopher M; Karp, Xantha; Ambros, Victor

    2009-11-03

    Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 larvae can enter the developmentally quiescent, stress-resistant dauer larva stage, enabling them to survive for prolonged periods before completing development. A specific progression of cell division and differentiation events occurs with fidelity during the larval stages, regardless of whether an animal undergoes continuous or dauer-interrupted development. The temporal patterning of developmental events is controlled by the heterochronic genes, whose products include microRNAs (miRNAs) and regulatory proteins. One of these proteins, the DAF-12 nuclear hormone receptor, modulates the transcription of certain let-7-family miRNAs, and also mediates the choice between the continuous vs. dauer-interrupted life history. Here, we report a complex feedback loop between DAF-12 and the let-7-family miRNAs involving both the repression of DAF-12 by let-7-family miRNAs and the ligand-modulated transcriptional activation and repression of the let-7-Fam miRNAs by DAF-12. We propose that this feedback loop functions to ensure robustness of cell fate decisions and to coordinate cell fate with developmental arrest.

  2. GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity.

    PubMed

    Das, U N

    1999-04-01

    GLUT-4 receptor, tumor necrosis factor-alpha (TNF-alpha), essential fatty acids (EFAs) and their metabolites and daf-genes seem to play an important and essential role in the maintenance of glucose homeostasis, and in the pathobiology of obesity and non-insulin dependent diabetes mellitus (NIDDM). Daf-genes encode for proteins which are 35% identical to the human insulin receptor, a transforming growth factor-beta (TGF-beta) type signal and can also enhance the expression of superoxide dismutase (SOD). On the other hand, EFAs and their metabolites can increase the cell membrane fluidity and thus, enhance the expression of GLUT-4 and insulin receptors. In addition, EFAs can suppress TNF-alpha production and secretion and thus, are capable of reversing insulin resistance. Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD. Hence, it is likely that there is a close interaction between GLUT-4, TNF-alpha, EFAs, daf-genes, melatonin and leptin that may have relevance to the development of insulin resistance, obesity, NIDDM, complications due to NIDDM, longevity and ageing.

  3. DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

    PubMed Central

    Tullet, Jennifer M. A.; Araiz, Caroline; Sanders, Matthew J.; Au, Catherine; Benedetto, Alexandre; Papatheodorou, Irene; Clark, Emily; Schmeisser, Kathrin; Jones, Daniel; Schuster, Eugene F.; Thornton, Janet M.; Gems, David

    2014-01-01

    The DAF-16/FoxO transcription factor controls growth, metabolism and aging in Caenorhabditis elegans. The large number of genes that it regulates has been an obstacle to understanding its function. However, recent analysis of transcript and chromatin profiling implies that DAF-16 regulates relatively few genes directly, and that many of these encode other regulatory proteins. We have investigated the regulation by DAF-16 of genes encoding the AMP-activated protein kinase (AMPK), which has α, β and γ subunits. C. elegans has 5 genes encoding putative AMP-binding regulatory γ subunits, aakg-1-5. aakg-4 and aakg-5 are closely related, atypical isoforms, with orthologs throughout the Chromadorea class of nematodes. We report that ∼75% of total γ subunit mRNA encodes these 2 divergent isoforms, which lack consensus AMP-binding residues, suggesting AMP-independent kinase activity. DAF-16 directly activates expression of aakg-4, reduction of which suppresses longevity in daf-2 insulin/IGF-1 receptor mutants. This implies that an increase in the activity of AMPK containing the AAKG-4 γ subunit caused by direct activation by DAF-16 slows aging in daf-2 mutants. Knock down of aakg-4 expression caused a transient decrease in activation of expression in multiple DAF-16 target genes. This, taken together with previous evidence that AMPK promotes DAF-16 activity, implies the action of these two metabolic regulators in a positive feedback loop that accelerates the induction of DAF-16 target gene expression. The AMPK β subunit, aakb-1, also proved to be up-regulated by DAF-16, but had no effect on lifespan. These findings reveal key features of the architecture of the gene-regulatory network centered on DAF-16, and raise the possibility that activation of AMP-independent AMPK in nutritionally replete daf-2 mutant adults slows aging in C. elegans. Evidence of activation of AMPK subunits in mammals suggests that such FoxO-AMPK interactions may be evolutionarily conserved

  4. Recognition of DAF and αvβ3 by inactivated Hantaviruses, towards the development of HTS flow cytometry assays

    PubMed Central

    Buranda, Tione; Wu, Yang; Perez, Dominique; Jett, Stephen D.; BonduHawkins, Virginie; Ye, Chunyan; Edwards, Bruce; Hall, Pamela; Larson, Richard S.; Lopez, Gabriel P.; Sklar, Larry A.; Hjelle, Brian

    2010-01-01

    Hantaviruses cause two severe diseases in humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardio-pulmonary syndrome (HCPS). The lack of vaccines or specific drugs to prevent or treat HFRS and HCPS, and the requirement for conducting experiments in a biosafety level 3 laboratory (BSL-3) limit the ability to probe the mechanism of infection and disease pathogenesis. In this study we have developed a generalizable spectroscopic assay to quantify saturable fluorophore sites solubilized in envelope membranes of Sin Nombre virus (SNV) particles. We then use flow cytometry and live cell confocal fluorescence microscopy imaging to show that UV-killed SNV bind to the cognate receptors of live virions, namely, decay accelerating factor (CD55/DAF) expressed on Tanoue B cells and αvβ3 integrins expressed on Vero E6 cells. SNV binding to DAF is multivalent and of high affinity (Kd ≈ 26pM). Self-exchange competition binding assays between fluorescently labeled SNV and unlabeled SNV are used to evaluate an infectious unit-to-particle ratio of ∼1:14000. We have configured the assay for measuring the binding of fluorescently labeled SNV to Tanoue B suspension cells using a high throughput flow cytometer. In this way, we establish a proof of principle high throughput screening assay for binding inhibition. This is a first step towards the development of HTS format assays for small molecule inhibitors of viral-cell interactions, as well as dissecting the mechanism of infection in a BSL-2 environment. PMID:20363206

  5. Comparison of inclined plate sedimentation and dissolved air flotation for the minimisation of subsequent nitrogenous disinfection by-product formation.

    PubMed

    Chu, Wen-Hai; Gao, Nai-Yun; Templeton, Michael R; Yin, Da-Qiang

    2011-04-01

    The formation of disinfection by-products (DBPs), including both nitrogenous disinfection by-products (N-DBPs) and carbonaceous disinfection by-products (C-DBPs), was investigated upon chlorination of water samples following two treatment processes: (i) coagulation-inclined plate sedimentation (IPS)-filtration and (ii) coagulation-dissolved air flotation (DAF)-filtration. The removal of algae, dissolved organic nitrogen (DON), dissolved organic carbon (DOC) and UV(254) by coagulation-DAF-filtration was superior to coagulation-IPS-filtration. On average, 53%, 53% and 31% of DOC, DON and UV(254) were removed by coagulation-DAF-filtration process, which were higher than 47%, 31% and 27% of that by coagulation-IPS-filtration process. Additionally, coagulation-IPS-filtration performed less well at removing the low molecular weight organics than coagulation-DAF-filtration process. The concentrations of chloroform, dichloroacetamide (DCAcAm) and dichloroacetonitrile (DCAN) formed during chlorination after coagulation-DAF-filtration reached their maximum values of 13, 1.5 and 4.7μgL(-1), respectively, and were lower than those after coagulation-IPS-filtration with the maximum detected levels of 17, 2.9 and 6.3μgL(-1). However, the trichloronitromethane (TCNM) concentration after the two processes was similar, suggesting that DON may have less of a contribution to TCNM formation than DCAcAm and DCAN.

  6. Removal of hydrocarbons from petrochemical wastewater by dissolved air flotation.

    PubMed

    Galil, N I; Wolf, D

    2001-01-01

    The dissolved air flotation (DAF) method has an important role in the removal of hydrocarbons, as well as in the protection of the biological treatment, which usually follows the DAF. The aims of this study were to evaluate the removal efficiencies of suspended solids, general organic matter, hydrocarbons and phenols by DAF, as influenced by the flocculant type, aluminum sulfate (alum) or a cationic polyelectrolyte. Laboratory batch experiments included chemical flocculation followed by DAF, controlling the flocculant dose and the air to solids ratio. The characterization of the influent and effluent was based on general analysis of organic matter (COD), suspended solids, hydrocarbons and phenols. The influent to all experiments was supplied daily from the outlet of a full scale oil-water gravitational separation unit at a petrochemical complex in Haifa, Israel. The influent contained hydrocarbons in the range of 20 to 77 mg/L. Usually less than 10% were found in "free" form, 70 to 80% were emulsified and 10 to 20% were dissolved. The DAF process enabled us to reduce the general hydrocarbon content by 50 to 90%. The effluent was characterized by stable and uniform levels of suspended solids, and oil, almost without depending on the influent concentrations. The results indicate that the chemical flocculation followed by DAF removed efficiently the emulsified phase, which could be aggregated and separated to the surface. However, it was found that the process could also remove substantial amounts of dissolved organic matter. This mechanism could be explained by the hydrophobic characteristics of some of the substances, which could bind to the solid surfaces. It was found that aggregates created by the flocculation with the cationic polyelectrolite (C-577) could remove up to 40% from the dissolved hydrocarbon. Alum flocs also indicated removal of soluble materials, mainly phenols. The results obtained in this study indicated the possibility to improve the protection

  7. Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants.

    PubMed

    Iser, Wendy B; Wilson, Mark A; Wood, William H; Becker, Kevin; Wolkow, Catherine A

    2011-03-09

    Insulin/IGF-I-like signaling (IIS) has both cell autonomous and non-autonomous functions. In some cases, targets through which IIS regulates cell-autonomous functions, such as cell growth and metabolism, have been identified. In contrast, targets for many non-autonomous IIS functions, such as C. elegans dauer morphogenesis, remain elusive. Here, we report the use of genomic and genetic approaches to identify potential non-autonomous targets of C. elegans IIS. First, we used transcriptional microarrays to identify target genes regulated non-autonomously by IIS in the intestine or in neurons. C. elegans IIS controls expression of a number of stress response genes, which were differentially regulated by tissue-restricted IIS. In particular, expression of sod-3, a MnSOD enzyme, was not regulated by tissue-restricted IIS on the microarrays, while expression of hsp-16 genes was rescued back to wildtype by tissue restricted IIS. One IIS target regulated non-autonomously by age-1 was cyp-35B1/dod-13, encoding a cytochrome P450. Genetic analysis of the cyp-35B1 promoter showed both DAF-16 and HSF-1 are direct regulators. Based on these findings, we propose that hsf-1 may participate in the pathways mediating non-autonomous activities of age-1 in C. elegans.

  8. Synthesis of new C-25 and C-26 steroidal acids as potential ligands of the nuclear receptors DAF-12, LXR and GR.

    PubMed

    Dansey, María V; Del Fueyo, María C; Veleiro, Adriana S; Di Chenna, Pablo H

    2017-05-01

    A new methodology to obtain C-25 and C-26 steroidal acids starting from pregnenolone is described. Construction of the side chain was achieved by applying the Mukaiyama aldol reaction with a non-hydrolytic work-up to isolate the trapped silyl enol ether with higher yields. Using this methodology we synthesized three new steroidal acids as potential ligands of DAF-12, Liver X and Glucocorticoid nuclear receptors and studied their activity in reporter gene assays. Our results show that replacement of the 21-CH3 by a 20-keto group in the side chains of the cholestane scaffold of DAF-12 or Liver X receptors ligands causes the loss of the activity.

  9. Optimization of Fenton's reagent coupled to Dissolved Air Flotation to remove cyanobacterial odorous metabolites and suspended solids from raw surface water.

    PubMed

    Elías-Maxil, Jorge A; Rigas, Fotis; Orta de Velásquez, María Teresa; Ramírez-Zamora, Rosa-María

    2011-01-01

    Ferrous salts are commonly used as coagulants in Water Treatment Plants (WTPs). When these salts are combined with hydrogen peroxide in acidic conditions - besides coagulation - an additional Advanced Oxidation Process (Fenton's reagent) can take place. Using a response surface methodology, this paper presents the optimization of a novel treatment system constituted by Fenton's reagent (FE) and Dissolved Air Flotation (DAF) for removing 2-Methylisoborneol (MIB), geosmin and Total Suspended Solids (TSS) from raw water. FE was proven able to remove completely both micro pollutants found in the influent of a drinking water treatment plant. Moreover, higher clarification rate was achieved by coupling FE-DAF with respect FE-Sedimentation.

  10. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans

    PubMed Central

    Amrit, Francis Raj Gandhi; Steenkiste, Elizabeth Marie; Ratnappan, Ramesh; Chen, Shaw-Wen; McClendon, T. Brooke; Kostka, Dennis; Yanowitz, Judith; Olsen, Carissa Perez; Ghazi, Arjumand

    2016-01-01

    Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we demonstrate that two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the expression of multiple genes involved in lipid synthesis and breakdown, and that both gene classes promote longevity. Lipidomic analyses revealed that key lipogenic processes, including de novo fatty acid synthesis, triglyceride production, desaturation and elongation, are augmented upon germline removal. Our data suggest that lipid anabolic and catabolic pathways are coordinately augmented in response to germline loss, and this metabolic shift helps preserve lipid homeostasis. DAF-16 and TCER-1 also perform essential inhibitory functions in germline-ablated animals. TCER-1 inhibits the somatic gene-expression program that facilitates reproduction and represses anti-longevity genes, whereas DAF-16 impedes ribosome biogenesis. Additionally, we discovered that TCER-1 is critical for optimal fertility in normal adults, suggesting that the protein acts as a switch supporting reproductive fitness or longevity depending on the presence or absence of the germline. Collectively, our data offer insights into how organisms adapt to changes in reproductive status, by utilizing the activating and repressive functions of transcription factors and coordinating fat production and degradation. PMID:26862916

  11. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.

    PubMed

    Amrit, Francis Raj Gandhi; Steenkiste, Elizabeth Marie; Ratnappan, Ramesh; Chen, Shaw-Wen; McClendon, T Brooke; Kostka, Dennis; Yanowitz, Judith; Olsen, Carissa Perez; Ghazi, Arjumand

    2016-02-01

    Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we demonstrate that two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the expression of multiple genes involved in lipid synthesis and breakdown, and that both gene classes promote longevity. Lipidomic analyses revealed that key lipogenic processes, including de novo fatty acid synthesis, triglyceride production, desaturation and elongation, are augmented upon germline removal. Our data suggest that lipid anabolic and catabolic pathways are coordinately augmented in response to germline loss, and this metabolic shift helps preserve lipid homeostasis. DAF-16 and TCER-1 also perform essential inhibitory functions in germline-ablated animals. TCER-1 inhibits the somatic gene-expression program that facilitates reproduction and represses anti-longevity genes, whereas DAF-16 impedes ribosome biogenesis. Additionally, we discovered that TCER-1 is critical for optimal fertility in normal adults, suggesting that the protein acts as a switch supporting reproductive fitness or longevity depending on the presence or absence of the germline. Collectively, our data offer insights into how organisms adapt to changes in reproductive status, by utilizing the activating and repressive functions of transcription factors and coordinating fat production and degradation.

  12. Dissolved air flotation as a potential treatment process to remove Giardia cysts from anaerobically treated sewage.

    PubMed

    Santos, Priscila Ribeiro Dos; Daniel, Luiz Antonio

    2016-11-30

    Controlling Giardia cysts in sewage is an essential barrier for public health protection, reducing possible routes of protozoa transmission. The aim of this study was to evaluate the capability of dissolved air flotation (DAF), on a bench scale, to remove Giardia cysts from anaerobic effluent. Moreover, removals of indicator microorganisms and physical variables were also investigated. Flocculation conditions were studied, associating different flocculation times with different mean velocity gradients. DAF treatment achieved mean log removals in the range of 2.52-2.62 for Giardia cysts, depending on the flocculation condition. No statistical differences were observed among the flocculation conditions in terms of cyst removal. Low levels of turbidity and apparent color obtained from the treated effluent may indicate good treatment conditions for the DAF process in cyst removal. Indicator microorganisms were not able to predict the parasitological quality of the wastewater treated by flotation in terms of cyst concentrations. The DAF process provided an effective barrier to control cysts from sewage, which is an important parasite source.

  13. Evaluation of flow hydrodynamics in a pilot-scale dissolved air flotation tank: a comparison between CFD and experimental measurements.

    PubMed

    Lakghomi, B; Lawryshyn, Y; Hofmann, R

    2015-01-01

    Computational fluid dynamics (CFD) models of dissolved air flotation (DAF) have shown formation of stratified flow (back and forth horizontal flow layers at the top of the separation zone) and its impact on improved DAF efficiency. However, there has been a lack of experimental validation of CFD predictions, especially in the presence of solid particles. In this work, for the first time, both two-phase (air-water) and three-phase (air-water-solid particles) CFD models were evaluated at pilot scale using measurements of residence time distribution, bubble layer position and bubble-particle contact efficiency. The pilot-scale results confirmed the accuracy of the CFD model for both two-phase and three-phase flows, but showed that the accuracy of the three-phase CFD model would partly depend on the estimation of bubble-particle attachment efficiency.

  14. Final Design for an International Intercomparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV: IER-148 CED-2 Report

    SciTech Connect

    Heinrichs, Dave; Beller, Tim; Burch, Jennifer; Cummings, Rick; Duluc, Matthieu; Gadd, Milan; Goda, Joetta; Hickman, David; McAvoy, Doug; Rathbone, Bruce; Sullivan, Randy; Trompier, Francois; Veinot, Ken; Ward, Dann; Will, Rashelle; Wilson, Chris; Zieziulewicz, Thomas

    2014-09-30

    This document is the Final Design (CED-2) Report for IER-148, “International Inter-comparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV.” The report describes the structure of the exercise consisting of three irradiations; identifies the participating laboratories and their points of contact; provides the details of all dosimetry elements and their placement in proximity to Godiva-IV on support stands or phantoms ; and lists the counting and spectroscopy equipment each laboratory will utilize in the Mercury NAD Lab. The exercise is tentatively scheduled for one week in August 2015.

  15. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16.

    PubMed

    Imae, M; Fu, Z; Yoshida, A; Noguchi, T; Kato, H

    2003-04-01

    Transcription factors of the FoxO family in mammals are orthologues of the Caenorhabditis elegans forkhead factor DAF-16, which has been characterized as a target of insulin-like signalling. Three members of this family have been identified in rodents: FoxO1, FoxO3 and FoxO4, originally termed FKHR, FKHRL1 and AFX respectively. A number of in vitro studies have revealed that FoxOs are regulated through phosphorylation in response to insulin and related growth factors, resulting in their nuclear exclusion and inactivation. To clarify the mechanisms involved in the regulation of these factors in vivo, we investigated in the present study whether or not, and if so how, their mRNA levels in rat liver respond to the stimuli of several nutritional and hormonal factors. Imposed fasting for 48 h significantly elevated mRNA levels of FoxO1 (1.5-fold), FoxO3 (1.4-fold), and FoxO4 (1.6-fold). Refeeding for 3 h recovered the induced mRNA levels of FoxO1 and FoxO3 to the control levels, but did not affect that of FoxO4. FoxO1 and FoxO4 mRNA levels were proved to be highly reflective of their protein levels measured by Western immunoblotting. Of the three FoxO genes, FoxO4 only showed altered levels of mRNA (a 1.5-fold increase) in response to a protein-free diet. Streptozotocin-induced diabetes for 28 days decreased hepatic mRNA levels of FoxO1 and FoxO3 and increased the level of FoxO4 mRNA, but short-term (7 days) diabetes had fewer effects on the expression of these genes. Insulin replacement partially restored the FoxO1 and FoxO4 mRNA levels, but had no effect on the FoxO3 mRNA level. Daily administration for 1 week of dexamethasone, a synthetic glucocorticoid, increased the mRNA levels of FoxO1 (1.8-fold) and FoxO3 (2.4-fold). These results show that the FoxO genes respond differently to nutritional and hormonal factors, suggesting a new mechanism for the regulation of FoxO-dependent gene expression by these factors. Moreover, changes of FoxO1 and FoxO4 in the nucleus in

  16. Complement regulatory proteins in early human fetal life: CD59, membrane co-factor protein (MCP) and decay-accelerating factor (DAF) are differentially expressed in the developing liver.

    PubMed Central

    Simpson, K L; Houlihan, J M; Holmes, C H

    1993-01-01

    The human fetus appears to be capable of protecting itself from maternal complement (C) from an early stage in development by expressing the C regulatory proteins decay-accelerating factor (DAF), membrane co-factor protein (MCP) and CD59 on fetally derived trophoblast at the feto-maternal interface. In this study we have examined the ontogeny of these proteins within the fetus itself and have focused on the liver which represents a major site of haemopoiesis during development. Immunostaining revealed that DAF, MCP and CD59 are all expressed from at least 6 weeks of gestation in the liver but that these proteins display distinct distribution patterns. CD59 was broadly distributed both within the epithelial and haemopoietic compartments, but expression of C3 convertase regulators was more restricted. DAF expression was limited to isolated cells within haemopoietic nests and the epithelium was DAF-negative. Although MCP expression on haemopoietic cells was also limited, by contrast with DAF the developing hepatic epithelium was strongly MCP-positive. Typical CD59 and MCP components were observed in fetal liver extracts by immunoblotting, although liver MCP components consistently migrated 4000-5000 MW ahead of those observed on placental trophoblast. Differences in the distribution of these proteins were also observed between the fetal and adult liver. In particular, by comparison with fetal hepatic epithelium, there was an apparent loss of MCP expression from adult hepatocytes. Thus, MCP appears to be developmentally regulated in the human liver and is expressed in the absence of DAF on the early hepatic epithelium. Overall, this study suggests that C regulatory proteins, and in particular CD59 and MCP, are required from the very early stages of gestation within the fetus itself. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:7505254

  17. A study on some welfare-related parameters of hDAF transgenic pigs when compared with their conventional close relatives.

    PubMed

    Martelli, G; Sardi, L; Stancampiano, L; Govoni, N; Zannoni, A; Nannoni, E; Forni, M; Bacci, M L

    2014-05-01

    Pigs are increasingly used in medical research as transgenic laboratory animals; however, little knowledge is presently available concerning their welfare assessment. The aim of the present study was to investigate some welfare-related parameters of transgenic pigs intended for xenotrasplantation (human decay-accelerating factor (hDAF)) when compared with their conventional (i.e. not transgenic) close relatives (full sibs and half sibs). A total of 14 Large White female transgenic pigs and 10 female non-transgenic (conventional) pigs from four litters were used. All pigs were from the same conventional boar, donor of the semen treated for sperm-mediated gene transfer. During the experiment, BW ranged from 50 to about 80 kg and pigs were weighed at the beginning and at the end of the experiment. Animals were subjected to a set of behavioural tests: a human approach test (HAT), a novel object test (NOT) and an open-door test (ODT). Food preferences were tested through the offer of different foods (banana, apple, carrot, cracker and lemon). During a 4-day period, pigs were diurnally videotaped to study the prevalence of the different behaviours and social interactions (aggressive and non-aggressive interactions). At the end of the trial, cortisol level had been assessed on bristles. No significant differences (P>0.05) were observed between hDAF transgenic and conventional pigs with respect to growth traits, reactivity towards unexpected situations (HAT, NOT, ODT), food preferences, main behavioural traits, social interactions and hair cortisol.

  18. Lamella dissolved air flotation treatment of fish farming effluents as a part of an integrated farming and effluent treatment concept.

    PubMed

    Jokela, Petri; Lepistö, Raghida

    2014-01-01

    Nutrient emissions from fish farming can be reduced by a bag pen, i.e., a floating circular basin which serves simultaneously both as a fish cultivation tank and a swirl separation tank. Solid matter (excreta and uneaten feed) is collected at the bottom of the bag pen and pumped as an underflow to a dissolved air flotation (DAF) unit for nutrient removal. DAF equipped with lamella elements was studied in real conditions. Altogether 3000 rainbow trout females (2.0 kg each) were cultivated. Solid-water mixture was pumped from the bottom of the bag pen to an equalizing basin using a sequence of 2-min pumping followed by a 4-min pause. In some tests the influent was pumped directly and continuously from the bag pen to DAF. The influent quality changed substantially: average suspended solids (SS) and phosphorus (P) concentrations were 290 mg l⁻¹ ± 110 mg l⁻¹ and 3.2 mg l⁻¹ ± 1.2 mg l⁻¹, respectively. When the influent was fresh and P strongly associated with SS, DAF without precipitation chemicals produced up to 86% SS and 83% P removals. The influence of chemical doses was studied using 6.4-29.2 mg Fe l⁻¹ with hydraulic loadings (HLs) of 11.0-11.7 m h⁻¹. SS and P removal did not change substantially and the effluent concentration levelled at 30 mg SS l⁻¹ and 0.20-0.30 mg P l⁻¹, respectively. The lamella DAF, coupled with ferric precipitation, produced up to 90% P and 80% nitrogen reductions. HLs, excluding recycle water flow and lamella projection, up to 21 m h⁻¹ could be used.

  19. Hydrophobically-associating cationic polymers as micro-bubble surface modifiers in dissolved air flotation for cyanobacteria cell separation.

    PubMed

    Yap, R K L; Whittaker, M; Diao, M; Stuetz, R M; Jefferson, B; Bulmus, V; Peirson, W L; Nguyen, A V; Henderson, R K

    2014-09-15

    Dissolved air flotation (DAF), an effective treatment method for clarifying algae/cyanobacteria-laden water, is highly dependent on coagulation-flocculation. Treatment of algae can be problematic due to unpredictable coagulant demand during blooms. To eliminate the need for coagulation-flocculation, the use of commercial polymers or surfactants to alter bubble charge in DAF has shown potential, termed the PosiDAF process. When using surfactants, poor removal was obtained but good bubble adherence was observed. Conversely, when using polymers, effective cell removal was obtained, attributed to polymer bridging, but polymers did not adhere well to the bubble surface, resulting in a cationic clarified effluent that was indicative of high polymer concentrations. In order to combine the attributes of both polymers (bridging ability) and surfactants (hydrophobicity), in this study, a commercially-available cationic polymer, poly(dimethylaminoethyl methacrylate) (polyDMAEMA), was functionalised with hydrophobic pendant groups of various carbon chain lengths to improve adherence of polymer to a bubble surface. Its performance in PosiDAF was contrasted against commercially-available poly(diallyl dimethyl ammonium chloride) (polyDADMAC). All synthesised polymers used for bubble surface modification were found to produce positively charged bubbles. When applying these cationic micro-bubbles in PosiDAF, in the absence of coagulation-flocculation, cell removals in excess of 90% were obtained, reaching a maximum of 99% cell removal and thus demonstrating process viability. Of the synthesised polymers, the polymer containing the largest hydrophobic functionality resulted in highly anionic treated effluent, suggesting stronger adherence of polymers to bubble surfaces and reduced residual polymer concentrations.

  20. Removal of emulsified fuel oils from brackish and pond water by dissolved air flotation with and without polyelectrolyte use: pilot-scale investigation for estuarine and near shore applications.

    PubMed

    Tansel, Berrin; Pascual, Beth

    2011-11-01

    In coastal areas, estuaries, and inland waters, dispersant use after oil spills is not allowed due to sensitivity of the ecosystems. The purpose of this study was to investigate the removal of emulsified fuel oils from brackish and pond water by dissolved air flotation (DAF) with and without use of coagulants. Experiments were conducted with a 60L DAF system. Fuel oil-water emulsions were prepared with regular unleaded gasoline, jet fuel, and diesel fuel mixed at 1:1:1 (v/v/v) ratio. Batch and continuous runs were conducted at air pressurization of 354.6kPa. During both batch and continuous modes, significant petroleum hydrocarbon (PHC) removal was achieved within 10 min. Coagulant addition initially increased the PHC removal by about 5-15%. However, effectiveness of the coagulant was not significant after 20 min due to breakage of the aggregates. In general, the pond water had higher PHC removal than the brackish water. With longer run times, PHC removal improved slightly and the effluent contained increasing fractions of higher molecular weight compounds indicating that PHC removal was due to both DAF and stripping processes. Results indicate that DAF process can be effective both with and without the use of coagulants for removing PHCs from brackish and pond waters.

  1. Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism.

    PubMed

    Fan, Lavender Yuen-Nam; Saavedra-García, Paula; Lam, Eric Wing-Fai

    2017-04-01

    The data presented in this article are related to the review article entitled 'Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis' (Saavedra-Garcia et al., 2017) [24]. Here, we have matched the DAF-16/FOXO3 downstream genes with their respective human orthologues and reviewed the roles of these targeted genes in FA metabolism. The list of genes listed in this article are precisely selected from literature reviews based on their functions in mammalian FA metabolism. The nematode Caenorhabditis elegans gene orthologues of the genes are obtained from WormBase, the online biological database of C. elegans. This dataset has not been uploaded to a public repository yet.

  2. Identification of tgh-2, a Filarial Nematode Homolog of Caenorhabditis elegans daf-7 and Human Transforming Growth Factor β, Expressed in Microfilarial and Adult Stages of Brugia malayi

    PubMed Central

    Gomez-Escobar, Natalia; Gregory, William F.; Maizels, Rick M.

    2000-01-01

    A novel member of the transforming growth factor β (TGF-β) family has been identified in the filarial nematode parasite Brugia malayi by searching the recently developed Expressed Sequence Tag (EST) database produced by the Filarial Genome Project. Designated tgh-2, this new gene shows most similarity to a key product regulating dauer larva formation in Caenorhabditis elegans (DAF-7) and to the human down-modulatory cytokine TGF-β. Homology to DAF-7 extends throughout the length of the 349-amino-acid (aa) protein, which is divided into an N-terminal 237 aa, including a putative signal sequence, a 4-aa basic cleavage site, and a 108-aa C-terminal active domain. Similarity to human TGF-β is restricted to the C-terminal domain, over which there is a 32% identity between TGH-2 and TGF-β1, including every cysteine residue. Expression of tgh-2 mRNA has been measured over the filarial life cycle. It is maximal in the microfilarial stage, with lower levels of activity around the time of molting within the mammal, but continues to be expressed by mature adult male and female parasites. Expression in both the microfilaria, which is in a state of arrested development, and the adult, which is terminally differentiated, indicates that tgh-2 may play a role other than purely developmental. This is consistent with our observation that TGH-2 is secreted by adult worms in vitro. Recombinant TGH-2 expressed in baculovirus shows a low level of binding to TGF-β-receptor bearing mink lung epithelial cells (MELCs), which is partially inhibited (16 to 39%) with human TGF-β, and activates plasminogen activator inhibitor-1 transcription in MELCs, a marker for TGF-β-mediated transduction. Further tests will be required to establish whether the major role of B. malayi TGH-2 (Bm-TGH-2) is to modulate the host immune response via the TGF-β pathway. PMID:11035752

  3. Carnitine protects the nematode Caenorhabditis elegans from glucose-induced reduction of survival depending on the nuclear hormone receptor DAF-12

    SciTech Connect

    Deusing, Dorothé Jenni Beyrer, Melanie Fitzenberger, Elena Wenzel, Uwe

    2015-05-08

    Besides its function in transport of fatty acids into mitochondria in order to provide substrates for β-oxidation, carnitine has been shown to affect also glucose metabolism and to inhibit several mechanisms associated with diabetic complications. In the present study we used the mev-1 mutant of the nematode Caenorhabditis elegans fed on a high glucose concentration in liquid media as a diabetes model and tested the effects of carnitine supplementation on their survival under heat-stress. Carnitine at 100 μM completely prevented the survival reduction that was caused by the application of 10 mM glucose. RNA-interference for sir-2.1, a candidate genes mediating the effects of carnitine revealed no contribution of the sirtuin for the rescue of survival. Under daf-12 RNAi rescue of survival by carnitine was abolished. RNA-interference for γ-butyrobetaine hydroxylase 2, encoding the key enzyme for carnitine biosynthesis did neither increase glucose toxicity nor prevent the rescue of survival by carnitine, suggesting that the effects of carnitine supplementation on carnitine levels were significant. Finally, it was demonstrated that neither the amount of lysosomes nor the proteasomal activity were increased by carnitine, excluding that protein degradation pathways, such as autophagy or proteasomal degradation, are involved in the protective carnitine effects. In conclusion, carnitine supplementation prevents the reduction of survival caused by glucose in C. elegans in dependence on a nuclear hormone receptor which displays high homologies to the vertebrate peroxisomal proliferator activated receptors. - Highlights: • Carnitine protects from glucose-induced reduction of stress-resistance. • Carnitine acts via the PPAR homolog DAF-12 on glucose toxicity. • Carnitine protects from glucose toxicity independent of protein degradation.

  4. Advanced water recycling through electrochemical treatment of effluent from dissolved air flotation unit of food processing industry.

    PubMed

    Yoo, Sukjoon; Hsieh, Jeffery S

    2010-01-01

    This study elucidates the feasibility of electrochemical treatment as a water recycling process in the dissolved air flotation (DAF) unit in the food industry. Effects of operation parameters such as current density, electrolysis time, initial pH of effluent, and mixing process were investigated on the removal of COD, TSS, and TDS of the DAF pretreated effluent. An increase of current density enhances the removal rates and reduces the electrolysis time to reach the maximum performance. The initial pH less than 7 and the addition of mixing process were proven to increase the efficiency of EC treatment. About 80% of COD, 100% of TSS, and 60% of TDS were successfully removed at 500 mA current for 1 hour of electrolysis. The final treated effluent was found to meet the discharge standard from the US Environmental Protection Agency. It was concluded that EC process could be effective as an advanced water resourcing technology in the food industry.

  5. Royal Jelly-Mediated Prolongevity and Stress Resistance in Caenorhabditis elegans Is Possibly Modulated by the Interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 Proteins.

    PubMed

    Wang, Xiaoxia; Cook, Lauren F; Grasso, Lindsay M; Cao, Min; Dong, Yuqing

    2015-07-01

    Recent studies suggest that royal jelly (RJ) and its related substances may have antiaging properties. However, the molecular mechanisms underlying the beneficial effects remain elusive. We report that the effects of RJ and enzyme-treated RJ (eRJ) on life span and health span in Caenorhabditis elegans (C elegans) are modulated by the sophisticated interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 proteins. Dietary supplementation with RJ or eRJ increased C. elegans life span in a dose-dependent manner. The RJ and eRJ consumption increased the tolerance of C elegans to oxidative stress, ultraviolet irradiation, and heat shock stress. Our genetic analyses showed that RJ/eRJ-mediated life-span extension requires insulin/IGF-1 signaling and the activities of DAF-16, SIR-2.1, HCF-1, and FTT-2, a 14-3-3 protein. Earlier studies reported that DAF-16/FOXO, SIR-2.1/SIRT1, FTT-2, and HCF-1 have extensive interplays in worms and mammals. Our present findings suggest that RJ/eRJ-mediated promotion of longevity and stress resistance in C elegans is dependent on these conserved interplays. From an evolutionary point of view, this study not only provides new insights into the molecular mechanisms of RJ's action on health span promotion in C elegans, but also has imperative implications in using RJ/eRJ as nutraceuticals to delay aging and age-related disorders.

  6. Carnitine protects the nematode Caenorhabditis elegans from glucose-induced reduction of survival depending on the nuclear hormone receptor DAF-12.

    PubMed

    Deusing, Dorothé Jenni; Beyrer, Melanie; Fitzenberger, Elena; Wenzel, Uwe

    2015-05-08

    Besides its function in transport of fatty acids into mitochondria in order to provide substrates for β-oxidation, carnitine has been shown to affect also glucose metabolism and to inhibit several mechanisms associated with diabetic complications. In the present study we used the mev-1 mutant of the nematode Caenorhabditis elegans fed on a high glucose concentration in liquid media as a diabetes model and tested the effects of carnitine supplementation on their survival under heat-stress. Carnitine at 100 μM completely prevented the survival reduction that was caused by the application of 10 mM glucose. RNA-interference for sir-2.1, a candidate genes mediating the effects of carnitine revealed no contribution of the sirtuin for the rescue of survival. Under daf-12 RNAi rescue of survival by carnitine was abolished. RNA-interference for γ-butyrobetaine hydroxylase 2, encoding the key enzyme for carnitine biosynthesis did neither increase glucose toxicity nor prevent the rescue of survival by carnitine, suggesting that the effects of carnitine supplementation on carnitine levels were significant. Finally, it was demonstrated that neither the amount of lysosomes nor the proteasomal activity were increased by carnitine, excluding that protein degradation pathways, such as autophagy or proteasomal degradation, are involved in the protective carnitine effects. In conclusion, carnitine supplementation prevents the reduction of survival caused by glucose in C. elegans in dependence on a nuclear hormone receptor which displays high homologies to the vertebrate peroxisomal proliferator activated receptors.

  7. Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans

    PubMed Central

    Wei, Chia-Cheng; Yen, Pei-Ling; Chang, Shang-Tzen; Cheng, Pei-Ling; Lo, Yi-Chen; Liao, Vivian Hsiu-Chuan

    2016-01-01

    Background Tea seed oil is a high quality edible oil, yet lacking sufficient scientific evidences to support the nutritional and medical purposes. We identified major and minor components in Camellia tenuifolia seed oil and investigated the antioxidative activity and its underlying mechanisms in Caenorhabditis elegans. Principal Findings The results showed that the major constitutes in C. tenuifolia seed oil were unsaturated fatty acids (~78.4%). Moreover, two minor compounds, β-amyrin and β-sitosterol, were identified and their antioxidative activity was examined. We found that oleic acid was the major constitute in C. tenuifolia seed oil and plays a key role in the antioxidative activity of C. tenuifolia seed oil in C. elegans. Conclusions This study found evidences that the transcription factor DAF-16/FOXO was involved in both oleic acid- and C. tenuifolia seed oil-mediated oxidative stress resistance in C. elegans. This study suggests the potential of C. tenuifolia seed oil as nutrient or functional foods. PMID:27275864

  8. On Using SysML, DoDAF 2.0 and UPDM to Model the Architecture for the NOAA's Joint Polar Satellite System (JPSS) Ground System (GS)

    NASA Technical Reports Server (NTRS)

    Hayden, Jeffrey L.; Jeffries, Alan

    2012-01-01

    The JPSS Ground System is a lIexible system of systems responsible for telemetry, tracking & command (TT &C), data acquisition, routing and data processing services for a varied lIeet of satellites to support weather prediction, modeling and climate modeling. To assist in this engineering effort, architecture modeling tools are being employed to translate the former NPOESS baseline to the new JPSS baseline, The paper will focus on the methodology for the system engineering process and the use of these architecture modeling tools within that process, The Department of Defense Architecture Framework version 2,0 (DoDAF 2.0) viewpoints and views that are being used to describe the JPSS GS architecture are discussed. The Unified Profile for DoOAF and MODAF (UPDM) and Systems Modeling Language (SysML), as ' provided by extensions to the MagicDraw UML modeling tool, are used to develop the diagrams and tables that make up the architecture model. The model development process and structure are discussed, examples are shown, and details of handling the complexities of a large System of Systems (SoS), such as the JPSS GS, with an equally complex modeling tool, are described

  9. Air Research

    EPA Pesticide Factsheets

    EPA's air research provides the critical science to develop and implement outdoor air regulations under the Clean Air Act and puts new tools and information in the hands of air quality managers and regulators to protect the air we breathe.

  10. Replacing synthetic with microbial surfactants as collectors in the treatment of aqueous effluent produced by acid mine drainage, using the dissolved air flotation technique.

    PubMed

    Menezes, Carlyle T B; Barros, Erilson C; Rufino, Raquel D; Luna, Juliana M; Sarubbo, Leonie A

    2011-02-01

    Dissolved air flotation (DAF) is a well-established separation process employing micro bubbles as a carrier phase. The application of this technique in the treatment of acid mine drainage, using three yeast biosurfactants as alternative collectors, is hereby analyzed. Batch studies were carried out in a 50-cm high acrylic column with an external diameter of 2.5 cm. High percentages (above 94%) of heavy metals Fe(III) and Mn(II) were removed by the biosurfactants isolated from Candida lipolytica and Candida sphaerica and the values were found to be similar to those obtained with the use of the synthetic sodium oleate surfactant. The DAF operation with both surfactant and biosurfactants, achieved acceptable turbidity values, in accordance with Brazilian standard limits. The best ones were obtained by the biosurfactant from C. lipolytica, which reached 4.8 NTU. The results obtained with a laboratory synthetic effluent were also satisfactory. The biosurfactants removed almost the same percentages of iron, while the removal percentages of manganese were slightly higher compared with those obtained in the acid mine drainage effluent. They showed that the use of low-cost biosurfactants as collectors in the DAF process is a promising technology for the mining industries.

  11. Elimination of TiO₂ nanoparticles with the assist of humic acid: influence of agglomeration in the dissolved air flotation process.

    PubMed

    Zhang, Ming; Guiraud, Pascal

    2013-09-15

    With recent advances in nanotechnology, environmental and health consequences of nanomaterial disposal merit close attention. In the search for environmentally-friendly reagent, this study investigates the use of humic acid (HA) as an assist of dissolved air flotation (DAF) in the TiO₂ nanoparticle (TNP) elimination. To determine mechanisms of TNPs interacting with HA, surface modification experiments were firstly carried out; thereafter, laboratory scaled DAF tests were applied to remove TNPs with HA assisting. Results of surface modification experiments showed that the zeta potential of TNP suspension system had a reversal trend due to counter ions of TNP and anions offered by the HA stock solution. The surface modified suspension was not easy to restabilize because of the close combination of TNPs and HA through sphere linkages or hydrogen-bonded surface complexes. Agglomeration took place more readily along with increasing HA concentration in the optimum dosage range (7.8-9.15 mg/L DOC). The flotation performance revealed that HA could improve the DAF efficiency in the optimum dosage range of HA. The interaction between TNPs and HA (Na(+)-humate), including surface charge neutralization (electrostatic interactions), sphere linkages or hydrogen-bonded surface complexes, hydrophobic interactions, and van der Waals interactions, played dominant roles.

  12. Air Pollution

    MedlinePlus

    Air pollution is a mixture of solid particles and gases in the air. Car emissions, chemicals from factories, ... Ozone, a gas, is a major part of air pollution in cities. When ozone forms air pollution, it's ...

  13. Utilization of calcium carbonate particles from eggshell waste as coating pigments for ink-jet printing paper.

    PubMed

    Yoo, Sukjoon; Hsieh, Jeffery S; Zou, Peter; Kokoszka, John

    2009-12-01

    The effective treatment and utilization of biowaste have been emphasized in our society for environmental and economic concerns. Recently, the eggshell waste in the poultry industry has been highlighted because of its reclamation potential. This study presents an economical treatment process to recover useful bioproducts from eggshell waste and their utilization in commercial products. We developed the dissolved air floatation (DAF) separation unit, which successfully recovered 96% of eggshell membrane and 99% of eggshell calcium carbonate (ECC) particles from eggshell waste within 2 h of operation. The recovered ECC particles were utilized as coating pigments for ink-jet printing paper and their impact on the ink density and paper gloss were investigated. The addition of the ECC particles as coating pigments enhances the optical density of cyan, magenta and yellow inks while decreasing the black ink density and the gloss of the coated paper.

  14. Air Pollution.

    ERIC Educational Resources Information Center

    Gilpin, Alan

    A summary of one of our most pressing environmental problems, air pollution, is offered in this book by the Director of Air Pollution Control for the Queensland (Australia) State Government. Discussion of the subject is not restricted to Queensland or Australian problems and policies, however, but includes analysis of air pollution the world over.…

  15. Air Pollution

    MedlinePlus

    ... of Climate Change on Children's Health: Session Two: Air Quality Impacts MODERATOR: Susan Anenberg, EPA Meredith McCormack, Johns ... University • Effects of Climate Change on Children’s Health: Air Quality Impacts Frederica Perera, Columbia University • Air quality Impacts ...

  16. Function of RSKS-1-AAK-2-DAF-16 signaling cascade in enhancing toxicity of multi-walled carbon nanotubes can be suppressed by mir-259 activation in Caenorhabditis elegans

    PubMed Central

    Zhuang, Ziheng; Li, Min; Liu, Hui; Luo, Libo; Gu, Weidong; Wu, Qiuli; Wang, Dayong

    2016-01-01

    Caenorhabditis elegans is an important non-mammalian alternative assay model for toxicological study. Previous study has indicated that exposure to multi-walled carbon nanotubes (MWCNTs) dysregulated the transcriptional expression of mir-259. In this study, we examined the molecular basis for mir-259 in regulating MWCNTs toxicity in nematodes. Mutation of mir-259 induced a susceptible property to MWCNTs toxicity, and MWCNTs exposure induced a significant increase in mir-259::GFP in pharyngeal/intestinal valve and reproductive tract, implying that mir-259 might mediate a protection mechanisms for nematodes against MWCNTs toxicity. RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity. Moreover, mir-259 functioned in pharynx-intestinal valve and RSKS-1 functioned in pharynx to regulate MWCNTs toxicity. Furthermore, RSKS-1 regulated MWCNTs toxicity by suppressing the function of AAK-2-DAF-16 signaling cascade. Our results will strengthen our understanding the microRNAs mediated protection mechanisms for animals against the toxicity from certain nanomaterials. PMID:27573184

  17. Function of RSKS-1-AAK-2-DAF-16 signaling cascade in enhancing toxicity of multi-walled carbon nanotubes can be suppressed by mir-259 activation in Caenorhabditis elegans

    NASA Astrophysics Data System (ADS)

    Zhuang, Ziheng; Li, Min; Liu, Hui; Luo, Libo; Gu, Weidong; Wu, Qiuli; Wang, Dayong

    2016-08-01

    Caenorhabditis elegans is an important non-mammalian alternative assay model for toxicological study. Previous study has indicated that exposure to multi-walled carbon nanotubes (MWCNTs) dysregulated the transcriptional expression of mir-259. In this study, we examined the molecular basis for mir-259 in regulating MWCNTs toxicity in nematodes. Mutation of mir-259 induced a susceptible property to MWCNTs toxicity, and MWCNTs exposure induced a significant increase in mir-259::GFP in pharyngeal/intestinal valve and reproductive tract, implying that mir-259 might mediate a protection mechanisms for nematodes against MWCNTs toxicity. RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity. Moreover, mir-259 functioned in pharynx-intestinal valve and RSKS-1 functioned in pharynx to regulate MWCNTs toxicity. Furthermore, RSKS-1 regulated MWCNTs toxicity by suppressing the function of AAK-2-DAF-16 signaling cascade. Our results will strengthen our understanding the microRNAs mediated protection mechanisms for animals against the toxicity from certain nanomaterials.

  18. Air Policing

    DTIC Science & Technology

    2009-05-01

    Iraq. To provide a background for understanding why Britain commenced the policy of air policing, this paper begins with a review of contemporary...7 Omissi, Air Power, XV. 8 policing actions or the pushing home of advantages gained by the air.” Within the context of this paper , the...control operations, and therefore within the context of this paper , the term coercive airpower refers to the threat of harming a population or the threat

  19. Air transport

    NASA Technical Reports Server (NTRS)

    Page, F Handley

    1924-01-01

    I purpose (sic) in this paper to deal with the development in air transport which has taken place since civil aviation between England and the Continent first started at the end of August 1919. A great deal of attention has been paid in the press to air services of the future, to the detriment of the consideration of results obtained up to the present.

  20. Air Pollution.

    ERIC Educational Resources Information Center

    Fox, Donald L.

    1989-01-01

    Materials related to air pollution are reviewed for the period January 1987, to October 1988. The topics are pollution monitoring, air pollution, and environmental chemistry. The organization consists of two major analytical divisions: (1) gaseous methods; and (2) aerosol and particulate methods. (MVL)

  1. Air Pollution.

    EPA Science Inventory

    Air quality is affected by many types of pollutants that are emitted from various sources, including stationary and mobile. These sources release both criteria and hazardous air pollutants, which cause health effects, ecological harm, and material damage. They are generally categ...

  2. Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase.

    PubMed

    Piekny, A J; Wissmann, A; Mains, P E

    2000-12-01

    let-502 rho-binding kinase and mel-11 myosin phosphatase regulate Caenorhabditis elegans embryonic morphogenesis. Genetic analysis presented here establishes the following modes of let-502 action: (i) loss of only maternal let-502 results in abnormal early cleavages, (ii) loss of both zygotic and maternal let-502 causes elongation defects, and (iii) loss of only zygotic let-502 results in sterility. The morphogenetic function of let-502 and mel-11 is apparently redundant with another pathway since elimination of these two genes resulted in progeny that underwent near-normal elongation. Triple mutant analysis indicated that unc-73 (Rho/Rac guanine exchange factor) and mlc-4 (myosin light chain) act in parallel to or downstream of let-502/mel-11. In contrast mig-2 (Rho/Rac), daf-2 (insulin receptor), and age-1 (PI3 kinase) act within the let-502/mel-11 pathway. Mutations in the sex-determination gene fem-2, which encodes a PP2c phosphatase (unrelated to the MEL-11 phosphatase), enhanced mutations of let-502 and suppressed those of mel-11. fem-2's elongation function appears to be independent of its role in sexual identity since the sex-determination genes fem-1, fem-3, tra-1, and tra-3 had no effect on mel-11 or let-502. By itself, fem-2 affects morphogenesis with low penetrance. fem-2 blocked the near-normal elongation of let-502; mel-11 indicating that fem-2 acts in a parallel elongation pathway. The action of two redundant pathways likely ensures accurate elongation of the C. elegans embryo.

  3. Air Apparent.

    ERIC Educational Resources Information Center

    Harbster, David A.

    1988-01-01

    Explains the principle upon which a barometer operates. Describes how to construct two barometric devices for use in the classroom that show air's changing pressure. Cites some conditions for predicting weather. (RT)

  4. Air Abrasion

    MedlinePlus

    ... information you need from the Academy of General Dentistry Sunday, April 9, 2017 About | Contact InfoBites Quick ... general dentist, who has been trained in restorative dentistry techniques, will perform any procedures that use air- ...

  5. Separation and recovery of thermoplastics by froth floatation

    SciTech Connect

    Karvelas, D. E.; Jody, B. J.; Pomykala, J., Jr.; Daniels, E. J.

    1999-10-22

    This paper describes efforts by Argonne National Laboratory to develop a froth flotation process for separating and recovering plastics from mixed plastics waste streams generated from shredding obsolete appliances and automobiles. A process for recovering and separating equivalent-density ABS and HIPS from obsolete appliances was developed and pilot-tested with a through-put of 1,250 lbs/hr. The basic process is outlined; unit operations and equipment are discussed, and material balances are presented. The resulting ABS product was analyzed and its physical and mechanical properties were established. Its properties resembled those of virgin, mid-grade ABS that is commercially sold today and is widely used by the automotive industry. Injection-molding tests were also conducted by automotive-components suppliers, using the 100% recovered ABS. Headlamp back-cans and automotive ventilation-system duct components were injection molded and the results showed that the recovered ABS met the specifications for these applications. These results confirmed that the recovered ABS can be used as a substitute for virgin plastic materials for molding highly complex automotive component designs, and in parts for other durable goods. Economic analysis of a commercial-scale system was also performed using manufacturers' equipment quotes and operating data from the pilot plant, and it predicts a simple payback of less than 2 years for plants producing about 850 tons per year of ABS.

  6. An Advanced Control System for Fine Coal Floatation

    SciTech Connect

    Luttrell, G H; Adel, G T

    1998-06-01

    A model-based flotation control scheme is being implemented to achieve optimal performance in the handling and treatment of fine coal. The control scheme monitors flotation performance through on-line analysis of ash content. Then, based on the economic and metallurgical performance of the circuit, variables such as collector dosage, frother dosage, and pulp level are adjusted using model-based control algorithms to compensate for feed variations and other process disturbances. Recent developments in sensor technology are being applied for on-line determination of slurry ash content. During the eighth quarter of this project, the analysis of data collected during Task 2 (Sampling and Data Analysis) was completed, and significant progress was made on Task 3 (Model Building and Computer Simulation). Previously, a plant sampling campaign had been conducted at Pittston's Moss No. 3 preparation plant to provide data for the development of a mathematical process model and a model-based control system. During this campaign, a one-half factorial design experiment, blocked into low and high feed rates, was conducted to investigate the effects of collector, frother, and pulp level on model parameters. In addition, samples were collected during the transient period following each change in the manipulated variables to provide data for confirmation of the dynamic process simulator. A residence time distribution (RTD) test was also conducted to estimate the mean residence time. This is a critical piece of information since no feed flowrate measurement is available, and the mean residence time can be used to estimate the feed flowrate. Feed samples were taken at timed intervals and floated in a laboratory flotation cell to investigate the magnitude of feed property disturbances and their duration.

  7. Hazardous Air Pollutants

    MedlinePlus

    ... Air Toxics Website Rules and Implementation Related Information Air Quality Data and Tools Clean Air Act Criteria Air ... Resources Visibility and Haze Voluntary Programs for Improving Air Quality Contact Us to ask a question, provide feedback, ...

  8. Air surveillance

    SciTech Connect

    Patton, G.W.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the air surveillance and monitoring programs currently in operation at that Hanford Site. Atmospheric releases of pollutants from Hanford to the surrounding region are a potential source of human exposure. For that reason, both radioactive and nonradioactive materials in air are monitored at a number of locations. The influence of Hanford emissions on local radionuclide concentrations was evaluated by comparing concentrations measured at distant locations within the region to concentrations measured at the Site perimeter. This section discusses sample collection, analytical methods, and the results of the Hanford air surveillance program. A complete listing of all analytical results summarized in this section is reported separately by Bisping (1995).

  9. /Air Atmospheres

    NASA Astrophysics Data System (ADS)

    Emami, Samar; Sohn, Hong Yong; Kim, Hang Goo

    2014-08-01

    Molten magnesium oxidizes rapidly when exposed to air causing melt loss and handling difficulties. The use of certain additive gases such as SF6, SO2, and CO2 to form a protective MgO layer over a magnesium melt has been proposed. The oxidation behavior of molten magnesium in air containing various concentrations of SF6 was investigated. Measurements of the kinetics of the oxide layer growth at various SF6 concentrations in air and temperatures were made. Experiments were performed using a thermogravimetric analysis unit in the temperature range of 943 K to 1043 K (670 °C to 770 °C). Results showed that a thin, coherent, and protective MgF2 layer was formed under SF6/Air mixtures, with a thickness ranging from 300 nm to 3 μm depending on SF6 concentration, temperature, and exposure time. Rate parameters were calculated and a model for the process was developed. The morphology and composition of the surface films were studied using scanning electron microscope and energy-dispersive spectroscope.

  10. Air Pollution.

    ERIC Educational Resources Information Center

    Scorer, Richard S.

    The purpose of this book is to describe the basic mechanisms whereby pollution is transported and diffused in the atmosphere. It is designed to give practitioners an understanding of basic mechanics and physics so they may have a correct basis on which to formulate their decisions related to practical air pollution control problems. Since many…

  11. Air pollution.

    PubMed

    Le, Nhu D; Sun, Li; Zidek, James V

    2010-01-01

    Toxic air pollutants are continuously released into the air supply. Various pollutants come from chemical facilities and small businesses, such as automobile service stations and dry cleaning establishments. Others, such as nitrogen oxides, carbon monoxide and other volatile organic chemicals, arise primarily from the incomplete combustion of fossil fuels (coal and petroleum) and are emitted from sources that include car exhausts, home heating and industrial power plants. Pollutants in the atmosphere also result from photochemical transformations; for example, ozone is formed when molecular oxygen or nitrogen interacts with ultraviolet radiation. An association between air pollution exposure and lung cancer has been observed in several studies. The evidence for other cancers is far less conclusive. Estimates of the population attributable risk of cancer has varied substantially over the last 40 years, reflecting the limitations of studies; these include insufficient information on confounders, difficulties in characterizing associations due to a likely lengthy latency interval, and exposure misclassification. Although earlier estimates were less than one percent, recent cohort studies that have taken into account some confounding factors, such as smoking and education amongst others, suggest that approximately 3.6% of lung cancer in the European Union could be due to air pollution exposure, particularly to sulphate and fine particulates. A separate cohort study estimated 5-7% of lung cancers in European never smokers and ex-smokers could be due to air pollution exposure. Therefore, while cigarette smoking remains the predominant risk factor, the proportion of lung cancers attributable to air pollution may be higher than previously thought. Overall, major weaknesses in all air-pollution-and-cancer studies to date have been inadequate characterization of long-term air pollution exposure and imprecise or no measurements of covariates. It has only been in the last

  12. Air Quality System (AQS)

    EPA Pesticide Factsheets

    The Air Quality System (AQS) database contains measurements of air pollutant concentrations from throughout the United States and its territories. The measurements include both criteria air pollutants and hazardous air pollutants.

  13. Ignition of an organic water-coal fuel droplet floating in a heated-air flow

    NASA Astrophysics Data System (ADS)

    Valiullin, T. R.; Strizhak, P. A.; Shevyrev, S. A.; Bogomolov, A. R.

    2017-01-01

    Ignition of an organic water-coal fuel (CWSP) droplet floating in a heated-air flow has been studied experimentally. Rank B2 brown-coal particles with a size of 100 μm, used crankcase Total oil, water, and a plasticizer were used as the main CWSP components. A dedicated quartz-glass chamber has been designed with inlet and outlet elements made as truncated cones connected via a cylindrical ring. The cones were used to shape an oxidizer flow with a temperature of 500-830 K and a flow velocity of 0.5-5.0 m/s. A technique that uses a coordinate-positioning gear, a nichrome thread, and a cutter element has been developed for discharging CWSP droplets into the working zone of the chamber. Droplets with an initial size of 0.4 to 2.0 mm were used. Conditions have been determined for a droplet to float in the oxidizer flow long enough for the sustainable droplet burning to be initiated. Typical stages and integral ignition characteristics have been established. The integral parameters (ignition-delay times) of the examined processes have been compared to the results of experiments with CWSP droplets suspended on the junction of a quick-response thermocouple. It has been shown that floating fuel droplets ignite much quicker than the ones that sit still on the thermocouple due to rotation of an CWSP droplet in the oxidizer flow, more uniform heating of the droplet, and lack of heat drainage towards the droplet center. High-speed video recording of the peculiarities of floatation of a burning fuel droplet makes it possible to complement the existing models of water-coal fuel burning. The results can be used for a more substantiated modeling of furnace CWSP burning with the ANSYS, Fluent, and Sigma-Flow software packages.

  14. Air cell

    NASA Astrophysics Data System (ADS)

    Okamura, Okiyoshi; Wakasa, Masayuki; Tamanoi, Yoshihito

    1991-04-01

    The present invention relates to an air cell. This air cell provides a compact light-weight power source for model aircraft permitting them to fly for an extended period so that they may be used for such practical purposes as crop dusting, surveying, and photographing. The cell is comprised of a current collector so disposed between a magnesium, zinc, or aluminum alloy cathode and a petroleum graphite anode that it is in contact with the anode. The anode is formed by adding polytetrafluoroethylene dispersion liquid in a mixture of active carbon and graphite powder, pouring the mixture into a mold and heating it to form the anode. It is fabricated by a plurality of anode sections and is formed with at least one hole so that it can provide a cell which is compact in size and light in weight yet is capable of generating a high output. The anode, the cathode, and a separator are wetted by an electrolytic liquid. The electrolyte is continuously supplied through the life of the cell.

  15. Metal-Air Batteries

    SciTech Connect

    Zhang, Jiguang; Bruce, Peter G.; Zhang, Gregory

    2011-08-01

    Metal-air batteries have much higher specific energies than most currently available primary and rechargeable batteries. Recent advances in electrode materials and electrolytes, as well as new designs on metal-air batteries, have attracted intensive effort in recent years, especially in the development of lithium-air batteries. The general principle in metal-air batteries will be reviewed in this chapter. The materials, preparation methods, and performances of metal-air batteries will be discussed. Two main metal-air batteries, Zn-air and Li-air batteries will be discussed in detail. Other type of metal-air batteries will also be described.

  16. Indoor Air Quality

    MedlinePlus

    ... can protect yourself and your family. Learn more Air Quality at Work Workers should breathe easy while on the job, but worksites with poor air quality put employees at risk. Healthy air is essential ...

  17. Air Sensor Toolbox

    EPA Pesticide Factsheets

    Air Sensor Toolbox provides information to citizen scientists, researchers and developers interested in learning more about new lower-cost compact air sensor technologies and tools for measuring air quality.

  18. HEPA air filter (image)

    MedlinePlus

    ... pet dander and other irritating allergens from the air. Along with other methods to reduce allergens, such ... controlling the amount of allergens circulating in the air. HEPA filters can be found in most air ...

  19. Needed: Clean Air.

    ERIC Educational Resources Information Center

    Schneider, Gerald

    1979-01-01

    Provides information on air pollution for young readers. Discusses damage to substances and sickness from air pollution, air quality, and what to do in a pollution alert. Includes questions with answers, illustrations, and activities for the learner. (MA)

  20. High efficiency air cycle air conditioning system

    SciTech Connect

    Rannenberg, G. C.

    1985-11-19

    An air cycle air conditioning system is provided with regenerative heat exchangers upstream and downstream of an expansion turbine. A closedloop liquid circulatory system serially connects the two regenerative heat exchangers for regeneration without the bulk associated with air-to-air heat exchange. The liquid circulatory system may also provide heat transport to a remote sink heat exchanger and from a remote load as well as heat exchange within the sink heat exchanger and load for enhanced compactness and efficiency.

  1. Air Pollution Monitoring | Air Quality Planning & Standards ...

    EPA Pesticide Factsheets

    2016-06-08

    The basic mission of the Office of Air Quality Planning and Standards is to preserve and improve the quality of our nation's air. To accomplish this, OAQPS must be able to evaluate the status of the atmosphere as compared to clean air standards and historical information.

  2. Primary zone air proportioner

    DOEpatents

    Cleary, Edward N. G.

    1982-10-12

    An air proportioner is provided for a liquid hydrocarbon fueled gas turbine of the type which is convertible to oil gas fuel and to coal gas fuel. The turbine includes a shell for enclosing the turbine, an air duct for venting air in said shell to a gasifier, and a fuel injector for injecting gasified fuel into the turbine. The air proportioner comprises a second air duct for venting air from the air duct for mixing with fuel from the gasifier. The air can be directly injected into the gas combustion basket along with the fuel from the injector or premixed with fuel from the gasifier prior to injection by the fuel injector.

  3. The Clean Air Game.

    ERIC Educational Resources Information Center

    Avalone-King, Deborah

    2000-01-01

    Introduces the Clean Air game which teaches about air quality and its vital importance for life. Introduces students to air pollutants, health of people and environment, and possible actions individuals can take to prevent air pollution. Includes directions for the game. (YDS)

  4. REACH. Air Conditioning Units.

    ERIC Educational Resources Information Center

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  5. Healthy Air Outdoors

    MedlinePlus

    ... families and can even shorten their lives. Outdoor Air Pollution and Health Outdoor air pollution continues to threaten the lives and health of ... sources such as fires and dust contribute to air pollution. Learn more Fighting for Healthy Air The American ...

  6. Isokinetic air sampler

    DOEpatents

    Sehmel, George A.

    1979-01-01

    An isokinetic air sampler includes a filter, a holder for the filter, an air pump for drawing air through the filter at a fixed, predetermined rate, an inlet assembly for the sampler having an inlet opening therein of a size such that isokinetic air sampling is obtained at a particular wind speed, a closure for the inlet opening and means for simultaneously opening the closure and turning on the air pump when the wind speed is such that isokinetic air sampling is obtained. A system incorporating a plurality of such samplers provided with air pumps set to draw air through the filter at the same fixed, predetermined rate and having different inlet opening sizes for use at different wind speeds is included within the ambit of the present invention as is a method of sampling air to measure airborne concentrations of particulate pollutants as a function of wind speed.

  7. Indoor Air Pollution

    MedlinePlus

    ... is known as sick building syndrome. Usually indoor air quality problems only cause discomfort. Most people feel better ... and getting rid of pollutants can improve the quality of your indoor air. Environmental Protection Agency

  8. Lead (Pb) Air Pollution

    MedlinePlus

    ... and 2014. In 2008, EPA significantly strengthened the air quality standards for lead to provide health protection for ... time? Setting and Reviewing Standards What are lead air quality standards? How are they developed and reviewed? What ...

  9. Transforming air quality management

    SciTech Connect

    Janet McCabe

    2005-04-01

    Earlier this year, the Clean Air Act Advisory Committee submitted to EPA 38 recommendations intended to improve air quality management in the United States. This article summarizes the evaluation process leading up to the Committee's recommendations. 3 refs., 2 figs.

  10. National Air Toxics Assessment

    EPA Pesticide Factsheets

    NATA is an ongoing comprehensive evaluation of air toxics in the U.S. As a screening tool, it helps air agencies prioritize pollutants, emission sources and locations of interest for further study to gain a better understanding of risks.

  11. Airing It Out.

    ERIC Educational Resources Information Center

    Fitzemeyer, Ted

    2000-01-01

    Discusses how proper maintenance can help schools eliminate sources contributing to poor air quality. Maintaining heating and air conditioning units, investigating bacterial breeding grounds, fixing leaking boilers, and adhering to ventilation codes and standards are discussed. (GR)

  12. Air Quality Analysis

    EPA Pesticide Factsheets

    This site provides information for air quality data analysts inside and outside EPA. Much of the information is in the form of documented analyses that support the review of the national air qualiyt standards.

  13. Controlling Indoor Air Pollution.

    ERIC Educational Resources Information Center

    Nero, Anthony V, Jr.

    1988-01-01

    Discusses the health risks posed by indoor air pollutants, such as airborne combustion products, toxic chemicals, and radioactivity. Questions as to how indoor air might be regulated. Calls for new approaches to environmental protection. (TW)

  14. Air Data - Concentration Map

    EPA Pesticide Factsheets

    Make a map of daily concentrations over several days. The daily air quality can be displayed in terms of the Air Quality Index or in concentration ranges for certain PM species like organic carbon, nitrates, and sulfates.

  15. Into Thin Air.

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2001-01-01

    Shows how schools are working to avoid the types of equipment, supplies, and maintenance practices that harm indoor air quality. Simple steps to maintaining a cleaner indoor air environment are highlighted as are steps to reducing the problem air quality and the occurrence of asthma. (GR)

  16. Indoor Air Quality Manual.

    ERIC Educational Resources Information Center

    Baldwin Union Free School District, NY.

    This manual identifies ways to improve a school's indoor air quality (IAQ) and discusses practical actions that can be carried out by school staff in managing air quality. The manual includes discussions of the many sources contributing to school indoor air pollution and the preventive planning for each including renovation and repair work,…

  17. Air Sensor Guidebook

    EPA Science Inventory

    This Air Sensor Guidebook has been developed by the U.S. EPA to assist those interested in potentially using lower cost air quality sensor technologies for air quality measurements. Its development was in direct response to a request for such a document following a recent scienti...

  18. Modelling Hot Air Balloons.

    ERIC Educational Resources Information Center

    Brimicombe, M. W.

    1991-01-01

    A macroscopic way of modeling hot air balloons using a Newtonian approach is presented. Misleading examples using a car tire and the concept of hot air rising are discussed. Pressure gradient changes in the atmosphere are used to explain how hot air balloons work. (KR)

  19. Air Pollution Training Programs.

    ERIC Educational Resources Information Center

    Public Health Service (DHEW), Rockville, MD.

    This catalog lists the universities, both supported and not supported by the Division of Air Pollution, which offer graduate programs in the field of air pollution. The catalog briefly describes the programs and their entrance requirements, the requirements, qualifications and terms of special fellowships offered by the Division of Air Pollution.…

  20. Clean Air Act Text

    EPA Pesticide Factsheets

    The Clean Air Act is the law that defines EPA's responsibilities for protecting and improving the nation's air quality and the stratospheric ozone layer. The last major change in the law, the Clean Air Act Amendments of 1990, enacted in 1990 by Congress.

  1. Air Conditioning Does Reduce Air Pollution Indoors

    ERIC Educational Resources Information Center

    Healy, Bud

    1970-01-01

    Report of the winter meeting of the American Society of Heating, Refrigerating and Air-Conditioning Engineers. Subjects covered are--(1) title subject, (2) predictions for the human habitat in 1994, (3) fans, and (4) fire safety in buildings. (JW)

  2. Air Parity: Re-Discovering Contested Air Operations

    DTIC Science & Technology

    2016-06-01

    AIR PARITY: RE-DISCOVERING CONTESTED AIR OPERATIONS BY CHRISTOPHER LAZIDIS A THESIS PRESENTED TO THE FACULTY OF...THE SCHOOL OF ADVANCED AIR AND SPACE STUDIES FOR COMPLETION OF GRADUATION REQUIREMENTS SCHOOL OF ADVANCED AIR AND SPACE STUDIES AIR ...UNIVERSITY MAXWELL AIR FORCE BASE, ALABAMA JUNE 2016 DISTRIBUTION A. Approved for public release: distribution unlimited ii APPROVAL The

  3. Air Conditioner/Dehumidifier

    NASA Technical Reports Server (NTRS)

    1986-01-01

    An ordinary air conditioner in a very humid environment must overcool the room air, then reheat it. Mr. Dinh, a former STAC associate, devised a heat pipe based humidifier under a NASA Contract. The system used heat pipes to precool the air; the air conditioner's cooling coil removes heat and humidity, then the heat pipes restore the overcooled air to a comfortable temperature. The heat pipes use no energy, and typical savings are from 15-20%. The Dinh Company also manufactures a "Z" coil, a retrofit cooling coil which may be installed on an existing heater/air conditioner. It will also provide free hot water. The company has also developed a photovoltaic air conditioner and solar powered water pump.

  4. Health Effects of Air Pollution

    MedlinePlus

    ... Health effects of air pollution Health effects of air pollution Breathing air that is not clean can hurt ... important to know about the health effects that air pollution can have on you and others. Once you ...

  5. Draft air deflecting device

    SciTech Connect

    Riley, J.E.

    1982-05-18

    A draft air deflecting device is mountable proximate to a window contained in a firebox and serves as a conduit which directs draft air across the inner surface of the window prior to its supporting combustion of the fuel in the firebox. In this respect , the draft air deflecting device is formed as a box which communicates with draft air holes located in the firebox and which includes a forwardly extending lip serving to define a nozzle for both increasing the velocity and directing the incoming draft air across the firebox window. The incoming draft air is thus utilized to cool and to prevent soot, creosote and other particulates from accumulating on the window.

  6. Air Power and Warfare

    DTIC Science & Technology

    1978-09-01

    American air ace.- New York: Putnam , 1958. (UG!3 290 G98) Guild, Richard E. The double attack system: a formalization. Yokota Air Base, Japan, 1968...1962) Sa..dby;•Robert H.M.S. Air bombardment: the story of it- development New York: Harper, 1961. (UGK 207 S25) Saunders, Hilary A.S. .Per ardua; the...1961. Letchworth, Herts: Harleyford Publications, 1961. (UGH 3215 .F5 887) Bruce, John N. British ,aeroplance 1914-1918. London: Putnam ; 1957. (Ref

  7. Contact air abrasion.

    PubMed

    Porth, R

    1999-05-01

    The advantages of contact air abrasion techniques are readily apparent. The first, of course, is the greatly increased ease of use. Working with contact also tends to speed the learning curve by giving the process a more natural dental feel. In addition, as one becomes familiar with working with a dust stream, the potential for misdirecting the air flow is decreased. The future use of air abrasion for deep decay removal will make this the treatment of choice for the next millennium.

  8. Applications Using AIRS Data

    NASA Astrophysics Data System (ADS)

    Ray, S. E.; Pagano, T. S.; Fetzer, E. J.; Lambrigtsen, B.; Olsen, E. T.; Teixeira, J.; Licata, S. J.; Hall, J. R.; Thompson, C. K.

    2015-12-01

    The Atmospheric Infrared Sounder (AIRS) on NASA's Aqua spacecraft has been returning daily global observations of Earth's atmospheric constituents and properties since 2002. With a 12-year data record and daily, global observations in near real-time, AIRS data can play a role in applications that fall under many of the NASA Applied Sciences focus areas. For vector-borne disease, research is underway using AIRS near surface retrievals to assess outbreak risk, mosquito incubation periods and epidemic potential for dengue fever, malaria, and West Nile virus. For drought applications, AIRS temperature and humidity data are being used in the development of new drought indicators and improvement in the understanding of drought development. For volcanic hazards, new algorithms using AIRS data are in development to improve the reporting of sulfur dioxide concentration, the burden and height of volcanic ash and dust, all of which pose a safety threat to aircraft. In addition, anomaly maps of many of AIRS standard products are being produced to help highlight "hot spots" and illustrate trends. To distribute it's applications imagery, AIRS is leveraging existing NASA data frameworks and organizations to facilitate archiving, distribution and participation in the BEDI. This poster will communicate the status of the applications effort for the AIRS Project and provide examples of new maps designed to best communicate the AIRS data.

  9. Air modulation apparatus

    NASA Technical Reports Server (NTRS)

    Lenahan, D. T.; Corsmeier, R. J.; Sterman, A. P. (Inventor)

    1983-01-01

    An air modulation apparatus, such as for use in modulating cooling air to the turbine section of a gas turbine engine is described. The apparatus includes valve means disposed around an annular conduit, such as a nozzle, in the engine cooling air circuit. The valve means, when in a closed position, blocks a portion of the conduit, and thus reduces the amount and increases the velocity of cooling air flowing through the nozzle. The apparatus also includes actuation means, which can operate in response to predetermined engine conditions, for enabling opening and closing of the valve means.

  10. Clean Air Excellence Awards

    EPA Pesticide Factsheets

    These non-monetary awards honor sustainable efforts toward pollutant emissions reduction from innovators in clean air technology, community action and outreach, policy development, and transportation efficiency.

  11. Personal continuous air monitor

    DOEpatents

    Morgan, Ronald G.; Salazar, Samuel A.

    2000-01-01

    A personal continuous air monitor capable of giving immediate warning of the presence of radioactivity has a filter/detector head to be worn in the breathing zone of a user, containing a filter mounted adjacent to radiation detectors, and a preamplifier. The filter/detector head is connected to a belt pack to be worn at the waist or on the back of a user. The belt pack contains a signal processor, batteries, a multichannel analyzer, a logic circuit, and an alarm. An air pump also is provided in the belt pack for pulling air through the filter/detector head by way of an air tube.

  12. Bad Air For Children

    ERIC Educational Resources Information Center

    Kane, Dorothy Noyes

    1976-01-01

    Children are especially sensitive to air pollution and consequences to them maybe of longer duration than to adults. The effects of low-level pollution on children are the concern of this article. The need for research on the threat of air pollution to childrens' health is emphasized. (BT)

  13. Next Generation Air Monitoring

    EPA Science Inventory

    Abstract. Air pollution measurement technology is advancing rapidly towards smaller-scale and wireless devices, with a potential to significantly change the landscape of air pollution monitoring. The U.S. EPA Office of Research and Development is evaluating and developing a rang...

  14. Nuclear air cushion vehicles

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.

    1973-01-01

    The state-of-the-art of the still-conceptual nuclear air cushion vehicle, particularly the nuclear powerplant is identified. Using mission studies and cost estimates, some of the advantages of nuclear power for large air cushion vehicles are described. The technology studies on mobile nuclear powerplants and conceptual ACV systems/missions studies are summarized.

  15. Air Pollution and Industry.

    ERIC Educational Resources Information Center

    Ross, R. D., Ed.

    This book is an authoritative reference and practical guide designed to help the plant engineer identify and solve industrial air pollution problems in order to be able to meet current air pollution regulations. Prepared under the editorial supervision of an experienced chemical engineer, with each chapter contributed by an expert in his field,…

  16. Discriminatory Air Pollution

    ERIC Educational Resources Information Center

    McCaull, Julian

    1976-01-01

    Described are the patterns of air pollution in certain large urban areas. Persons in poverty, in occupations below the management or professional level, in low-rent districts, and in black population are most heavily exposed to air pollution. Pollution paradoxically is largely produced by high energy consuming middle-and upper-class households.…

  17. Air Pollution, Teachers' Edition.

    ERIC Educational Resources Information Center

    Lavaroni, Charles W.; O'Donnell, Patrick A.

    One of three in a series about pollution, this teacher's guide for a unit on air pollution is designed for use in junior high school grades. It offers suggestions for extending the information and activities contained in the textual material for students. Chapter 1 discusses the problem of air pollution and involves students in processes of…

  18. Air Cargo Marketing Development

    NASA Technical Reports Server (NTRS)

    Kersey, J. W.

    1972-01-01

    The factors involved in developing a market for air cargo services are discussed. A comparison is made between the passenger traffic problems and those of cargo traffic. Emphasis is placed on distribution analyses which isolates total distribution cost, including logistical costs such as transportation, inventory, materials handling, packaging, and processing. Specific examples of methods for reducing air cargo costs are presented.

  19. Recirculating electric air filter

    DOEpatents

    Bergman, Werner

    1986-01-01

    An electric air filter cartridge has a cylindrical inner high voltage eleode, a layer of filter material, and an outer ground electrode formed of a plurality of segments moveably connected together. The outer electrode can be easily opened to remove or insert filter material. Air flows through the two electrodes and the filter material and is exhausted from the center of the inner electrode.

  20. Air Pollution Primer.

    ERIC Educational Resources Information Center

    National Tuberculosis and Respiratory Disease Association, New York, NY.

    As the dangers of polluted air to the health and welfare of all individuals became increasingly evident and as the complexity of the causes made responsibility for solutions even more difficult to fix, the National Tuberculosis and Respiratory Disease Association felt obligated to give greater emphasis to its clean air program. To this end they…

  1. AIR HEATER EXPERIMENT,

    DTIC Science & Technology

    The test program described in this report was designed to determine the feasibility of using a vitiated air heater for the PLUTO facility from the...profiles across the outlet proved relatively flat. The feasibility of using this burner for PLUTO facility air heating was established. (Author)

  2. AIR RADIOACTIVITY MONITOR

    DOEpatents

    Bradshaw, R.L.; Thomas, J.W.

    1961-04-11

    The monitor is designed to minimize undesirable background buildup. It consists of an elongated column containing peripheral electrodes in a central portion of the column, and conduits directing an axial flow of radioactively contaminated air through the center of the column and pure air through the annular portion of the column about the electrodes. (AEC)

  3. The Air We Breathe

    NASA Technical Reports Server (NTRS)

    Davila, Dina

    2010-01-01

    Topics discussed include NASA mission to pioneer the future in space exploration, scientific discovery and aeronautics research; the role of Earth's atmosphere, atmospheric gases, layers of the Earth's atmosphere, ozone layer, air pollution, effects of air pollution on people, the Greenhouse Effect, and breathing on the International Space Station.

  4. Air pollution and society

    NASA Astrophysics Data System (ADS)

    Brimblecombe, P.

    2010-12-01

    Air pollution is as much a product of our society as it is one of chemistry and meteorology. Social variables such as gender, age, health status and poverty are often linked with our exposure to air pollutants. Pollution can also affect our behaviour, while regulations to improve the environment can often challenge of freedom.

  5. Recirculating electric air filter

    DOEpatents

    Bergman, W.

    1985-01-09

    An electric air filter cartridge has a cylindrical inner high voltage electrode, a layer of filter material, and an outer ground electrode formed of a plurality of segments moveably connected together. The outer electrode can be easily opened to remove or insert filter material. Air flows through the two electrodes and the filter material and is exhausted from the center of the inner electrode.

  6. Portable oven air circulator

    DOEpatents

    Jorgensen, Jorgen A.; Nygren, Donald W.

    1983-01-01

    A portable air circulating apparatus for use in cooking ovens which is used to create air currents in the oven which transfer heat to cooking foodstuffs to promote more rapid and more uniform cooking or baking, the apparatus including a motor, fan blade and housing of metallic materials selected from a class of heat resistant materials.

  7. Bearings Only Air-to-Air Ranging

    DTIC Science & Technology

    1988-07-25

    sensor, observer and target parameters still remain. In order to reduce the number of cases to a manageable one, while preserving the geometric...perforance of variotu. ulro-air passive ranging tecnique has been examined as a fimn- tiam of uarget location andi motiom, observer motion. and length

  8. Culture systems: air quality.

    PubMed

    Thomas, Theodore

    2012-01-01

    Poor laboratory air quality is a known hazard to the culture of human gametes and embryos. Embryologists and chemists have employed analytical methods for identifying and measuring bulk and select air pollutants to assess the risk they pose to the embryo culture system. However, contaminant concentrations that result in gamete or embryotoxicity are poorly defined. Combating the ill effects of poor air quality requires an understanding of how toxicants can infiltrate the laboratory, the incubator, and ultimately the culture media. A further understanding of site-specific air quality can then lead to the consideration of laboratory design and management strategies that can minimize the deleterious effects that air contamination may have on early embryonic development in vitro.

  9. Airing 'clean air' in Clean India Mission.

    PubMed

    Banerjee, T; Kumar, M; Mall, R K; Singh, R S

    2016-12-30

    The submission explores the possibility of a policy revision for considering clean air quality in recently launched nationwide campaign, Clean India Mission (CIM). Despite of several efforts for improving availability of clean household energy and sanitation facilities, situation remain still depressing as almost half of global population lacks access to clean energy and proper sanitation. Globally, at least 2.5 billion people do not have access to basic sanitation facilities. There are also evidences of 7 million premature deaths by air pollution in year 2012. The situation is even more disastrous for India especially in rural areas. Although, India has reasonably progressed in developing sanitary facilities and disseminating clean fuel to its urban households, the situation in rural areas is still miserable and needs to be reviewed. Several policy interventions and campaigns were made to improve the scenario but outcomes were remarkably poor. Indian census revealed a mere 31% sanitation coverage (in 2011) compared to 22% in 2001 while 60% of population (700 million) still use solid biofuels and traditional cook stoves for household cooking. Further, last decade (2001-2011) witnessed the progress decelerating down with rural households without sanitation facilities increased by 8.3 million while minimum progress has been made in conversion of conventional to modern fuels. To revamp the sanitation coverage, an overambitious nationwide campaign CIM was initiated in 2014 and present submission explores the possibility of including 'clean air' considerations within it. The article draws evidence from literatures on scenarios of rural sanitation, energy practises, pollution induced mortality and climatic impacts of air pollution. This subsequently hypothesised with possible modification in available technologies, dissemination modes, financing and implementation for integration of CIM with 'clean air' so that access to both sanitation and clean household energy may be

  10. Air ejector augmented compressed air energy storage system

    DOEpatents

    Ahrens, F.W.; Kartsounes, G.T.

    Energy is stored in slack demand periods by charging a plurality of underground reservoirs with air to the same peak storage pressure, during peak demand periods throttling the air from one storage reservoir into a gas turbine system at a constant inlet pressure until the air presure in the reservoir falls to said constant inlet pressure, thereupon permitting air in a second reservoir to flow into said gas turbine system while drawing air from the first reservoir through a variable geometry air ejector and adjusting said variable geometry air ejector, said air flow being essentially at the constant inlet pressure of the gas turbine system.

  11. Air ejector augmented compressed air energy storage system

    DOEpatents

    Ahrens, Frederick W.; Kartsounes, George T.

    1980-01-01

    Energy is stored in slack demand periods by charging a plurality of underground reservoirs with air to the same peak storage pressure, during peak demand periods throttling the air from one storage reservoir into a gas turbine system at a constant inlet pressure until the air pressure in the reservoir falls to said constant inlet pressure, thereupon permitting air in a second reservoir to flow into said gas turbine system while drawing air from the first reservoir through a variable geometry air ejector and adjusting said variable geometry air ejector, said air flow being essentially at the constant inlet pressure of the gas turbine system.

  12. Air washer/scrubber

    SciTech Connect

    Brown, L.H.; Gerdes, D.F.; Telchuk, S.E.

    1982-05-04

    An air washer or scrubber, particularly for paint spray booths and especially adapted for removing paint particles from air passing downwardly through the grille floor of a paint spray booth and against a water-washed subfloor, comprises an elongated v-shaped slot in the subfloor extending along the longitudinal centerline of the booth. The inner edges of the walls forming the v-shaped slot are upturned to form ledges so that water flowed over the subfloor and the walls of the slot impinges against the ledges and is thrown upwardly and inwardly to form a curtain of water completely covering the slot. Exhaust means pulls paintladen air from the spray chamber through the water curtain and the slot and into an expansion chamber, the bottom walls of which form a second v-shaped slot contiguous with the first mentioned slot. The water, in which virtually all of the paint particles are entrained, and the air are discharged from the second slot and impinged against a baffle sheet angling downwardly away from the expansion chamber. The end of the sheet is upturned at a small angle to deflect the water and form an umbrella of water through which the air must pass for a final cleaning action. An optional curved deflector plate positioned beneath the umbrella of water aids in separating the water and air so that only clean, dry air is exhausted to atmosphere.

  13. Air Cleaning Technologies

    PubMed Central

    2005-01-01

    Executive Summary Objective This health technology policy assessment will answer the following questions: When should in-room air cleaners be used? How effective are in-room air cleaners? Are in-room air cleaners that use combined HEPA and UVGI air cleaning technology more effective than those that use HEPA filtration alone? What is the Plasmacluster ion air purifier in the pandemic influenza preparation plan? The experience of severe acute respiratory syndrome (SARS) locally, nationally, and internationally underscored the importance of administrative, environmental, and personal protective infection control measures in health care facilities. In the aftermath of the SARS crisis, there was a need for a clearer understanding of Ontario’s capacity to manage suspected or confirmed cases of airborne infectious diseases. In so doing, the Walker Commission thought that more attention should be paid to the potential use of new technologies such as in-room air cleaning units. It recommended that the Medical Advisory Secretariat of the Ontario Ministry of Health and Long-Term Care evaluate the appropriate use and effectiveness of such new technologies. Accordingly, the Ontario Health Technology Advisory Committee asked the Medical Advisory Secretariat to review the literature on the effectiveness and utility of in-room air cleaners that use high-efficiency particle air (HEPA) filters and ultraviolet germicidal irradiation (UVGI) air cleaning technology. Additionally, the Ontario Health Technology Advisory Committee prioritized a request from the ministry’s Emergency Management Unit to investigate the possible role of the Plasmacluster ion air purifier manufactured by Sharp Electronics Corporation, in the pandemic influenza preparation plan. Clinical Need Airborne transmission of infectious diseases depends in part on the concentration of breathable infectious pathogens (germs) in room air. Infection control is achieved by a combination of administrative, engineering

  14. Air Quality Management Process Cycle

    EPA Pesticide Factsheets

    Air quality management are activities a regulatory authority undertakes to protect human health and the environment from the harmful effects of air pollution. The process of managing air quality can be illustrated as a cycle of inter-related elements.

  15. Ozone - Current Air Quality Index

    MedlinePlus

    Local Air Quality Conditions Zip Code: State : My Current Location Forecast Current AQI AQI Loop More Maps AQI: Good (0 - ... September 2016, Busan, South Korea. More more announcements Air Quality Basics Air Quality Index | Ozone | Particle Pollution | Smoke ...

  16. Air Quality Guide for Ozone

    MedlinePlus

    Local Air Quality Conditions Zip Code: State : My Current Location Air Quality Guide for Ozone Ground-level ozone is one ... exposure and protect your health. For your local air quality, visit www.airnow.gov View or print guide ...

  17. Lean in Air Permitting Guide

    EPA Pesticide Factsheets

    The Lean in Air Permitting Guide is designed to help air program managers at public agencies better understand the potential value and results that can be achieved by applying Lean improvement methods to air permitting processes.

  18. Liquid-Air Breathing Apparatus

    NASA Technical Reports Server (NTRS)

    Mills, Robert D.

    1990-01-01

    Compact unit supplies air longer than compressed-air unit. Emergency breathing apparatus stores air as cryogenic liquid instead of usual compressed gas. Intended for firefighting or rescue operations becoming necessary during planned potentially hazardous procedures.

  19. Particulate Air Pollution: The Particulars

    ERIC Educational Resources Information Center

    Murphy, James E.

    1973-01-01

    Describes some of the causes and consequences of particulate air pollution. Outlines the experimental procedures for measuring the amount of particulate materials that settles from the air and for observing the nature of particulate air pollution. (JR)

  20. Air Shower Simulations

    SciTech Connect

    Alania, Marco; Gomez, Adolfo V. Chamorro; Araya, Ignacio J.; Huerta, Humberto Martinez; Flores, Alejandra Parra; Knapp, Johannes

    2009-04-30

    Air shower simulations are a vital part of the design of air shower experiments and the analysis of their data. We describe the basic features of air showers and explain why numerical simulations are the appropriate approach to model the shower simulation. The CORSIKA program, the standard simulation program in this field, is introduced and its features, performance and limitations are discussed. The basic principles of hadronic interaction models and some gerneral simulation techniques are explained. Also a brief introduction to the installation and use of CORSIKA is given.

  1. Air/Water Purification

    NASA Technical Reports Server (NTRS)

    1992-01-01

    After 18 years of research into air/water pollution at Stennis Space Center, Dr. B. C. Wolverton formed his own company, Wolverton Environmental Services, Inc., to provide technology and consultation in air and water treatment. Common houseplants are used to absorb potentially harmful materials from bathrooms and kitchens. The plants are fertilized, air is purified, and wastewater is converted to clean water. More than 100 U.S. communities have adopted Wolverton's earlier water hyacinth and artificial marsh applications. Catfish farmers are currently evaluating the artificial marsh technology as a purification system.

  2. Ventilating Air-Conditioner

    NASA Technical Reports Server (NTRS)

    Dinh, Khanh

    1994-01-01

    Air-conditioner provides ventilation designed to be used alone or incorporated into cooling or heating system operates efficiently only by recirculating stale air within building. Energy needed to operate overall ventilating cooling or heating system slightly greater than operating nonventilating cooling or heating system. Helps to preserve energy efficiency while satisfying need for increased forced ventilation to prevent accumulation of undesired gases like radon and formaldehyde. Provides fresh treated air to variety of confined spaces: hospital surgeries, laboratories, clean rooms, and printing shops and other places where solvents used. In mobile homes and portable classrooms, eliminates irritant chemicals exuded by carpets, panels, and other materials, ensuring healthy indoor environment for occupants.

  3. Air conditioned suit

    NASA Technical Reports Server (NTRS)

    Carl, G. R. (Inventor)

    1973-01-01

    An environmentally controlled suit is described consisting of an airtight outergarment attached by an airtight bellows to the wall of a sterile chamber, an undergarment providing for circulation of air near the skin of the wearer, and a circulation system comprised of air supply and distribution to the extremities of the undegarment and central collection and exhaust of air from the midsection of the undergarment. A workman wearing the undergarment and attached circulation system enters the outer garment through a tunnel in the chamber wall and the attached bellows to work in the chamber without any danger of spreading bacteria.

  4. Air Pollution Exposure

    PubMed Central

    Balmes, John R.; Collard, Harold R.

    2015-01-01

    Air pollution exposure is a well-established risk factor for several adverse respiratory outcomes, including airways diseases and lung cancer. Few studies have investigated the relationship between air pollution and interstitial lung disease (ILD) despite many forms of ILD arising from environmental exposures. There are potential mechanisms by which air pollution could cause, exacerbate, or accelerate the progression of certain forms of ILD via pulmonary and systemic inflammation as well as oxidative stress. This article will review the current epidemiologic and translational data supporting the plausibility of this relationship and propose a new conceptual framework for characterizing novel environmental risk factors for these forms of lung disease. PMID:25846532

  5. Air Force Research Laboratory

    DTIC Science & Technology

    2009-06-08

    Air Force Research Laboratory 8 June 2009 Mr. Leo Marple Ai F R h L b t r orce esearc a ora ory Leo.Marple@wpafb.af.mil DISTRIBUTION STATEMENT A...TITLE AND SUBTITLE Air Force Research Laboratory 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air Force Research Laboratory ,Wright

  6. Indoor Air Quality

    NASA Astrophysics Data System (ADS)

    Miyazaki, Takeji

    The reduction of intake of outdoor air volume in air conditioned buildings, adopted as the strategy for saving energy, has caused sick building syndrome abroad. Such symptoms of sick building as headache, stimuli of eye and nose and lethargy, appears to result from cigarette smoke, folmaldehyde and volatile organic carbons. On the other hand, in airtight residences not only carbon monoxide and nitrogen oxides from domestic burning appliances but also allergens of mite, fungi, pollen and house dust, have become a subject of discussion. Moreover, asbestos and radon of carcinogen now attract a great deal of attention. Those indoor air pollutants are discussed.

  7. Air heating system

    DOEpatents

    Primeau, John J.

    1983-03-01

    A self-starting, fuel-fired, air heating system including a vapor generator, a turbine, and a condenser connected in a closed circuit such that the vapor output from the vapor generator is conducted to the turbine and then to the condenser where it is condensed for return to the vapor generator. The turbine drives an air blower which passes air over the condenser for cooling the condenser. Also, a condensate pump is driven by the turbine. The disclosure is particularly concerned with the provision of heat exchanger and circuitry for cooling the condensed fluid output from the pump prior to its return to the vapor generator.

  8. Olefin metathesis in air

    PubMed Central

    Piola, Lorenzo; Nahra, Fady

    2015-01-01

    Summary Since the discovery and now widespread use of olefin metathesis, the evolution of metathesis catalysts towards air stability has become an area of significant interest. In this fascinating area of study, beginning with early systems making use of high oxidation state early transition metal centers that required strict exclusion of water and air, advances have been made to render catalysts more stable and yet more functional group tolerant. This review summarizes the major developments concerning catalytic systems directed towards water and air tolerance. PMID:26664625

  9. Criteria air pollutants and toxic air pollutants.

    PubMed Central

    Suh, H H; Bahadori, T; Vallarino, J; Spengler, J D

    2000-01-01

    This review presents a brief overview of the health effects and exposures of two criteria pollutants--ozone and particulate matter--and two toxic air pollutants--benzene and formaldehyde. These pollutants were selected from the six criteria pollutants and from the 189 toxic air pollutants on the basis of their prevalence in the United States, their physicochemical behavior, and the magnitude of their potential health threat. The health effects data included in this review primarily include results from epidemiologic studies; however, some findings from animal studies are also discussed when no other information is available. Health effects findings for each pollutant are related in this review to corresponding information about outdoor, indoor, and personal exposures and pollutant sources. Images Figure 3 Figure 8 Figure 9 PMID:10940240

  10. Air Quality Implementation Plans

    EPA Pesticide Factsheets

    States must develop plans to attain and maintain air quality standards. These plans, known as SIPs, are submitted to EPA for approval. This web site contains information about this process and the current status of the submittals.

  11. Calidad del aire interior

    EPA Pesticide Factsheets

    This web site will educate the public about indoor environmental issues including health risks and means by which human exposures can be reduced. Content on this site will be focused on Spanish translated resources for information about indoor air quality.

  12. Air bag restraint device

    DOEpatents

    Marts, D.J.; Richardson, J.G.

    1995-10-17

    A rear-seat air bag restraint device is disclosed that prevents an individual, or individuals, from continuing violent actions while being transported in a patrol vehicle`s rear seat without requiring immediate physical contact by the law enforcement officer. The air bag is activated by a control switch in the front seat and inflates to independently restrict the amount of physical activity occurring in the rear seat of the vehicle while allowing the officer to safely stop the vehicle. The air bag can also provide the officer additional time to get backup personnel to aid him if the situation warrants it. The bag is inflated and maintains a constant pressure by an air pump. 8 figs.

  13. Air bag restraint device

    DOEpatents

    Marts, Donna J.; Richardson, John G.

    1995-01-01

    A rear-seat air bag restraint device is disclosed that prevents an individual, or individuals, from continuing violent actions while being transported in a patrol vehicle's rear seat without requiring immediate physical contact by the law enforcement officer. The air bag is activated by a control switch in the front seat and inflates to independently restrict the amount of physical activity occurring in the rear seat of the vehicle while allowing the officer to safely stop the vehicle. The air bag can also provide the officer additional time to get backup personnel to aid him if the situation warrants it. The bag is inflated and maintains a constant pressure by an air pump.

  14. AIR POLLUTION CONTROL TECHNOLOGIES

    EPA Science Inventory

    This is a chapter for John Wiley & Son's Mechanical Engineers' Handbook, and covers issues involving air pollution control. Various technologies for controlling sulfur oxides is considered including fuel desulfurization. It also considers control of nitrogen oxides including post...

  15. Temporal solitons in air

    NASA Astrophysics Data System (ADS)

    Voronin, A. A.; Zheltikov, A. M.

    2017-02-01

    Analysis of the group-velocity dispersion (GVD) of atmospheric air with a model that includes the entire manifold of infrared transitions in air reveals a remarkably broad and continuous anomalous-GVD region in the high-frequency wing of the carbon dioxide rovibrational band from approximately 3.5 to 4.2 μm where atmospheric air is still highly transparent and where high-peak-power sources of ultrashort midinfrared pulses are available. Within this range, anomalous dispersion acting jointly with optical nonlinearity of atmospheric air is shown to give rise to a unique three-dimensional dynamics with well-resolved soliton features in the time domain, enabling a highly efficient whole-beam soliton self-compression of such pulses to few-cycle pulse widths.

  16. Air conditioning system

    DOEpatents

    Lowenstein, Andrew; Miller, Jeffrey; Gruendeman, Peter; DaSilva, Michael

    2005-02-01

    An air conditioner comprises a plurality of plates arranged in a successively stacked configuration with portions thereof having a spaced apart arrangement, and defining between successive adjacent pairs of plates at the spaced apart portions a first and second series of discrete alternating passages wherein a first air stream is passed through the first series of passages and a second air stream is passed through the second series of passages; and said stacked configuration of plates forming integrally therewith a liquid delivery means for delivering from a source a sufficient quantity of a liquid to the inside surfaces of the first series of fluid passages in a manner which provides a continuous flow of the liquid from a first end to a second end of the plurality of plates while in contact with the first air stream.

  17. Breathing zone air sampler

    DOEpatents

    Tobin, John

    1989-01-01

    A sampling apparatus is provided which comprises a sampler for sampling air in the breathing zone of a wearer of the apparatus and a support for the sampler preferably in the form of a pair of eyeglasses. The sampler comprises a sampling assembly supported on the frame of the eyeglasses and including a pair of sample transport tubes which are suspended, in use, centrally of the frame so as to be disposed on opposite sides of the nose of the wearer and which each include an inlet therein that, in use, is disposed adjacent to a respective nostril of the nose of the wearer. A filter holder connected to sample transport tubes supports a removable filter for filtering out particulate material in the air sampled by the apparatus. The sample apparatus is connected to a pump for drawing air into the apparatus through the tube inlets so that the air passes through the filter.

  18. Walking On Air

    NASA Video Gallery

    This video features a series of time lapse sequences photographed by the Expedition 30 crew aboard the International Space Station. Set to the song "€œWalking in the Air,"€ by Howard Blake, the v...

  19. Natural Air Purifier

    NASA Technical Reports Server (NTRS)

    1993-01-01

    NASA environmental research has led to a plant-based air filtering system. Dr. B.C. Wolverton, a former NASA engineer who developed a biological filtering system for space life support, served as a consultant to Terra Firma Environmental. The company is marketing the BioFilter, a natural air purifier that combines activated carbon and other filter media with living plants and microorganisms. The filter material traps and holds indoor pollutants; plant roots and microorganisms then convert the pollutants into food for the plant. Most non-flowering house plants will work. After pollutants have been removed, the cleansed air is returned to the room through slits in the planter. Terra Firma is currently developing a filter that will also disinfect the air.

  20. Process air quality data

    NASA Technical Reports Server (NTRS)

    Butler, C. M.; Hogge, J. E.

    1978-01-01

    Air quality sampling was conducted. Data for air quality parameters, recorded on written forms, punched cards or magnetic tape, are available for 1972 through 1975. Computer software was developed to (1) calculate several daily statistical measures of location, (2) plot time histories of data or the calculated daily statistics, (3) calculate simple correlation coefficients, and (4) plot scatter diagrams. Computer software was developed for processing air quality data to include time series analysis and goodness of fit tests. Computer software was developed to (1) calculate a larger number of daily statistical measures of location, and a number of daily monthly and yearly measures of location, dispersion, skewness and kurtosis, (2) decompose the extended time series model and (3) perform some goodness of fit tests. The computer program is described, documented and illustrated by examples. Recommendations are made for continuation of the development of research on processing air quality data.

  1. Air cushion landing system

    NASA Technical Reports Server (NTRS)

    Boghami, K. M.; Captain, K. M.; Fish, R. B.

    1978-01-01

    Static and dynamic performance of air cushion landing system is simulated in computer program that treats four primary ACLS subsystems: fan, feeding system, trunk, and cushion. Configuration of systems is sufficiently general to represent variety of practical designs.

  2. Siting Air Monitoring Stations

    ERIC Educational Resources Information Center

    Ludwig, F. L.

    1978-01-01

    Describes guidelines for consideration in selecting sites for air monitoring systems. Careful selection for spatial scale and specific sources assures that the collected data are accurately representing the situation. (Author/MA)

  3. Air Force Junior ROTC

    ERIC Educational Resources Information Center

    McDonnell, James A., Jr.

    1974-01-01

    Describes the Junior Air Force Reserve Officers Training Corps (AFROTC) program presently being operated in 275 units across the country. It is basically a three year course in aerospace studies and leadership education. (BR)

  4. State Air Quality Standards.

    ERIC Educational Resources Information Center

    Pollution Engineering, 1978

    1978-01-01

    This article presents in tabular form the air quality standards for sulfur dioxide, carbon monoxide, nitrogen dioxide, photochemicals, non-methane hydrocarbons and particulates for each of the 50 states and the District of Columbia. (CS)

  5. Air Traffic Network Project

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The high level requirement of the Air Traffic Network (ATN) project is to provide a mechanism for evaluating the impact of router scheduling modifications on a networks efficiency, without implementing the modifications in the live network.

  6. Improving Indoor Air Quality

    EPA Pesticide Factsheets

    Usually the most effective way to improve indoor air quality is to eliminate individual sources of pollution or to reduce their emissions. Some sources, like those that contain asbestos, can be sealed or enclosed.

  7. Investigating Air Pollution

    ERIC Educational Resources Information Center

    Carter, Edward J.

    1977-01-01

    Describes an experiment using live plants and cigarette smoke to demonstrate the effects of air pollution on a living organism. Procedures include growth of the test plants in glass bottles, and construction and operation of smoking machine. (CS)

  8. Breathing zone air sampler

    SciTech Connect

    Tobin, J.

    1989-08-22

    A sampling apparatus is presented which comprises a sampler for sampling air in the breathing zone of a wearer of the apparatus and a support for the sampler preferably in the form of a pair of eyeglasses. The sampler comprises a sampling assembly supported on the frame of the eyeglasses and including a pair of sample transport tubes which are suspended, in use, centrally of the frame so as to be disposed on opposite sides of the nose of the wearer and which each include an inlet therein that, in use, is disposed adjacent to a respective nostril of the nose of the wearer. A filter holder connected to sample transport tubes supports a removable filter for filtering out particulate material in the air sampled by the apparatus. The sample apparatus is connected to a pump for drawing air into the apparatus through the tube inlets so that the air passes through the filter.

  9. Images in the air

    NASA Astrophysics Data System (ADS)

    Riveros, H. G.; Rosenberger, Franz

    2012-05-01

    This article discusses two 'magic tricks' in terms of underlying optical principles. The first trick is new and produces a 'ghost' in the air, and the second is the classical real image produced with two parabolic mirrors.

  10. Air transportation energy efficiency

    NASA Technical Reports Server (NTRS)

    Williams, L. J.

    1977-01-01

    The energy efficiency of air transportation, results of the recently completed RECAT studies on improvement alternatives, and the NASA Aircraft Energy Efficiency Research Program to develop the technology for significant improvements in future aircraft were reviewed.

  11. Military Air Cargo Containerization.

    DTIC Science & Technology

    1996-05-01

    MILITARY AIR CARGO CONTAINERIZATION GRADUATE RESEARCH PAPER Joseph W. Mancy, Major, USAF AFIT/ GMO /LAL/96J-4 : ."•" ’* ■- ’ DEPARTMENT OF...Approved to public release; Distribution UnHmlted ? DTIC QUALITY INSPECTED 1 AFIT/ GMO /LAL/96J-4 MILITARY AIR CARGO CONTAINERIZATION GRADUATE RESEARCH...PAPER Joseph W. Mancy, Major, USAF AFIT/ GMO /LAL/96J-4 19960617 134 Approved for public release; distribution unlimited The views expressed in this

  12. Air pollution from aircraft

    NASA Technical Reports Server (NTRS)

    Heywood, J. B.; Fay, J. A.; Chigier, N. A.

    1979-01-01

    A series of fundamental problems related to jet engine air pollution and combustion were examined. These include soot formation and oxidation, nitric oxide and carbon monoxide emissions mechanisms, pollutant dispension, flow and combustion characteristics of the NASA swirl can combustor, fuel atomization and fuel-air mixing processes, fuel spray drop velocity and size measurement, ignition and blowout. A summary of this work, and a bibliography of 41 theses and publications which describe this work, with abstracts, is included.

  13. Air Superiority Fighter Characteristics.

    DTIC Science & Technology

    1998-06-05

    many a dispute could have been deflated into a single paragraph if the disputants had just dared to define their terms.7 Aristotle ...meaningful. This section will expand on some key ideology concepts. The phrase "air superiority fighter" may bring to mind visions of fighter... biographies are useful in garnering airpower advocate theories as well as identifying key characteristics. Air campaign results, starting with World

  14. Nuclear air cushion vehicles.

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.

    1973-01-01

    This paper serves several functions. It identifies the 'state-of-the-art' of the still-conceptual nuclear air cushion vehicle, particularly the nuclear powerplant. Using mission studies and cost estimates, the report describes some of the advantages of nuclear power for large air cushion vehicles. The paper also summarizes the technology studies on mobile nuclear powerplants and conceptual ACV systems/missions studies that have been performed at NASA Lewis Research Center.

  15. Multipollutant air quality management.

    PubMed

    Hidy, George M; Pennell, William T

    2010-06-01

    On the basis of a recent NARSTO assessment, this review discusses the factors involved in the implementation of a risk- and results-based multipollutant air quality management strategy applicable to North America. Such a strategy could evolve from current single-pollutant regulatory practices using a series of steps that would seek to minimize risk of exposure for humans and ecosystems while providing for a quantitative evaluation of the effectiveness of the management process. The tools needed to support multipollutant air quality management are summarized. They include application of a formal risk analysis, accounting for atmospheric processes, ambient measurements, emissions characterization, air quality modeling of emissions to ambient concentrations, and characterization of human and ecological responses to ambient pollutant exposure. The new management strategy would expand the current practice of accountability that relates emission reductions and attainment of air quality derived from air quality criteria and standards. Conceptually, achievement of accountability would establish goals optimizing risk reduction associated with pollution management. This expanded approach takes into account the sequence of processes from emissions reduction to resulting changes in ambient concentration. Using ambient concentration as a proxy for exposure, the resulting improvement in human and ecosystem health is estimated. The degree to which this chain of processes and effects can be achieved in current practice is examined in a multipollutant context exemplified by oxidants, as indicated by ozone, particulate matter, and some hazardous air pollutants. Achievement of a multipollutant management strategy will mostly depend on improving knowledge about human and ecosystem response to pollutant exposure.

  16. Air injection system diagnostic

    SciTech Connect

    Kotzan, J.M.; Labus, G.E.

    1992-05-19

    This patent describes a method for diagnosing failures in an air control system that controls a quantity of air admitted into an exhaust path of an internal combustion engine. It comprises sensing the oxygen content of the exhaust gas of the engine at predetermined time intervals at a first predetermined point in the exhaust path of the engine, the oxygen content normally oscillating between a rich oxygen condition and a lean oxygen condition in the absence of air injected into the exhaust path above the first predetermined point; injecting a quantity of air into the exhaust path of the engine at a second predetermined point in the exhaust port, the second predetermined point being above the first predetermined point; counting the number of intervals at which the sensed oxygen content indicates a rich oxygen condition over a predetermined period of time; comparing the counted number of rich oxygen intervals to a predetermined threshold value, the threshold value being greater than a counted number of rich oxygen intervals over the predetermined period of time resulting from the normal oscillations between rich and lean oxygen conditions in the absence of air injected into the exhaust path; indicating the existence of a fault in the air control system when the number of rich oxygen intervals does not exceed the predetermined threshold value.

  17. Developing air quality forecasts

    NASA Astrophysics Data System (ADS)

    Lee, Pius; Saylor, Rick; Meagher, James

    2012-05-01

    Third International Workshop on Air Quality Forecasting Research; Potomac, Maryland, 29 November to 1 December 2011 Elevated concentrations of both near-surface ozone (O3) and fine particulate matter smaller than 2.5 micrometers in diameter have been implicated in increased mortality and other human health impacts. In light of these known influences on human health, many governments around the world have instituted air quality forecasting systems to provide their citizens with advance warning of impending poor air quality so that they can take actions to limit exposure. In an effort to improve the performance of air quality forecasting systems and provide a forum for the exchange of the latest research in air quality modeling, the International Workshop on Air Quality Forecasting Research (IWAQFR) was established in 2009 and is cosponsored by the U.S. National Oceanic and Atmospheric Administration (NOAA), Environment Canada (EC), and the World Meteorological Organization (WMO). The steering committee for IWAQFR's establishment was composed of Véronique Bouchet, Mike Howe, and Craig Stoud (EC); Greg Carmichael (University of Iowa); Paula Davidson and Jim Meagher (NOAA); and Liisa Jalkanen (WMO). The most recent workshop took place in Maryland.

  18. 77 FR 1513 - Air Show and Air Races; Public Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office NATIONAL TRANSPORTATION SAFETY BOARD Air Show and Air Races; Public Hearing TIME AND DATE: 9 a.m., Tuesday, January 10, 2012... hearing is to examine current regulations and oversight practices for air shows and air races,...

  19. The Air Advisor: The Face of US Air Force Engagement

    DTIC Science & Technology

    2013-08-01

    Senior Leader Perspective July–August 2013 Air & Space Power Journal | 4 The Air Advisor The Face of US Air Force Engagement Maj Gen Timothy M...The Air Advisor: The Face of US Air Force Engagement 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air Force Research Institute,Air & Space Power Journal

  20. Performance evaluation of a granular activated carbon-sequencing batch biofilm reactor pilot plant system used in treating real wastewater from recycled paper industry.

    PubMed

    Muhamad, Mohd Hafizuddin; Sheikh Abdullah, Siti Rozaimah; Mohamad, Abu Bakar; Rahman, Rakmi Abdul; Kadhum, Abdul Amir Hasan

    2012-01-01

    A pilot scale granular activated carbon-sequencing batch biofilm reactor with a capacity of 2.2 m3 was operated for over three months to evaluate its performance treating real recycled paper industry wastewater under different operational conditions. In this study, dissolved air floatation (DAF) and clarifier effluents were used as influent sources of the pilot plant. During the course of the study, the reactor was able to biodegrade the contaminants in the incoming recycled paper mill wastewater in terms of chemical oxygen demand (COD), adsorbable organic halides (AOX; specifically 2,4-dichlorophenol (2,4-DCP)) and ammoniacal nitrogen (NH3-N) removal efficiencies at varying hydraulic retention times (HRTs) of 1-3 days, aeration rates (ARs) of 2.1-3.4 m3/min and influent feed concentration of 40-950 mg COD/l. Percentages of COD, 2,4-DCP and NH3-N removals increased with increasing HRT, resulting in more than 90% COD, 2,4-DCP and NH3-N removals at HRT values above two days. Degradation of COD, 2,4-DCP and NH3-N were seriously affected by variation of ARs, which resulted in significant decrease of COD, 2,4-DCP and NH3-N removals by decreasing ARs from 3.4 m3/min to 2.1 m3/min, varying in the ranges of 24-80%, 6-96% and 5-42%, respectively. In comparison to the clarifier effluent, the treatment performance of DAF effluent, containing high COD concentration, resulted in a higher COD removal of 82%. The use of diluted DAF effluent did not improve significantly the COD removal. Higher NH3-N removal efficiency of almost 100% was observed during operation after maintenance shutdown compared to normal operation, even at the same HRT of one day due to the higher dissolved oxygen concentrations (1-7 mg/l), while no significant difference in COD removal efficiency was observed.

  1. Infants Can Study Air Science.

    ERIC Educational Resources Information Center

    Ward, Alan

    1983-01-01

    Provided are activities and demonstrations which can be used to teach infants about the nature of air, uses of air, and objects that fly in the air. The latter include airships, hot-air balloons, kites, parachutes, airplanes, and Hovercraft. (JN)

  2. UPDM - Unified Profile for DoDAF/MODAF

    DTIC Science & Technology

    2012-04-01

    Expected target DoDAF 2.03 – MODAF MODEM – DNDAF 1.7 may also be required by the Canadians – UML for  BPMN  profile • Allows the seamless integration of... BPMN  artefacts into a DoDAF  Architecture along with an exchange environment – Others? – Priorities will be based on demand and participation • UPDM 2...19         ,  ,  ,  . • Provides flow‐down, traceability, integration across sectors • BPMN  integration is under development UPDM – Unified Profile

  3. 33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force....

  4. 33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force....

  5. 33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force....

  6. 33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force....

  7. 33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force....

  8. Air diverter for supercharger

    SciTech Connect

    Johnson, K.A.

    1986-10-28

    An engine supercharger is described which consists of a turbine housing, a main turbine wheel of the radial-inflow type located within the turbine housing, a compressor housing having an air entrance passageway, and a compressor wheel of the centrifugal type located within the compressor housing. It also includes a main shaft of annular construction interconnecting the turbine wheel and the compressor wheel whereby the two wheels rotate as a unit, an auxiliary turbine wheel of the axial flow type located downstream from the main turbine wheel, and a fan of the axial flow type located upstream from the compressor wheel. An auxiliary shaft extends within the main shaft between the auxiliary turbine and fan whereby the auxiliary turbine and fan rotate as a unit. An annular air collector chamber means is located immediately downstream from the fan in surrounding relation to the aforementioned entrance passageway for diverting some of the fan air from the compressor wheel. The fan comprises a hub and blades radiating outwardly therefrom. The air collector chamber is defined in part by an annular wall having a free edge located within the fan blade axial profile whereby the annular wall intercepts air discharged from outer tip areas of the fan blades to divert same away from the compressor wheel into the collector chamber.

  9. Air Compliance Complaint Database (ACCD)

    EPA Pesticide Factsheets

    THIS DATA ASSET NO LONGER ACTIVE: This is metadata documentation for the Region 7 Air Compliance Complaint Database (ACCD) which logs all air pollution complaints received by Region 7. It contains information about the complaint along with how the complaint was addressed. The Air and Waste Management Division is the primary managing entity for this database. This work falls under objectives for EPA's 2003-2008 Strategic Plan (Goal 1) for Clean Air & Global Climate Change, which are to achieve healthier outdoor air.

  10. Compressed air energy storage system

    DOEpatents

    Ahrens, F.W.; Kartsounes, G.T.

    An internal combustion reciprocating engine is operable as a compressor during slack demand periods utilizing excess power from a power grid to charge air into an air storage reservoir and as an expander during peak demand periods to feed power into the power grid utilizing air obtained from the air storage reservoir together with combustion reciprocating engine is operated at high pressure and a low pressure turbine and compressor are also employed for air compression and power generation.

  11. Compressed air energy storage system

    DOEpatents

    Ahrens, Frederick W.; Kartsounes, George T.

    1981-01-01

    An internal combustion reciprocating engine is operable as a compressor during slack demand periods utilizing excess power from a power grid to charge air into an air storage reservoir and as an expander during peak demand periods to feed power into the power grid utilizing air obtained from the air storage reservoir together with combustible fuel. Preferably the internal combustion reciprocating engine is operated at high pressure and a low pressure turbine and compressor are also employed for air compression and power generation.

  12. AIR COOLED NEUTRONIC REACTOR

    DOEpatents

    Fermi, E.; Szilard, L.

    1958-05-27

    A nuclear reactor of the air-cooled, graphite moderated type is described. The active core consists of a cubicle mass of graphite, approximately 25 feet in each dimension, having horizontal channels of square cross section extending between two of the opposite faces, a plurality of cylindrical uranium slugs disposed in end to end abutting relationship within said channels providing a space in the channels through which air may be circulated, and a cadmium control rod extending within a channel provided in the moderator. Suitable shielding is provlded around the core, as are also provided a fuel element loading and discharge means, and a means to circulate air through the coolant channels through the fuel charels to cool the reactor.

  13. Air Sparging Design Paradigm

    DTIC Science & Technology

    2002-08-12

    that the air distribution in the aquifer is non-uniform about the air injection, exhibiting tendencies to flow along the axis defined by MP6 , MP12...MW2 MW9 MW7 MW1 MW3 MP9, N9 MP11, N11 MP5, N5 MP7, N7 MP12, N12 MP6 , N6 MP3, N3MP1, N1 - Multi-level sampler and neutron access tube - Air...MP9 and MP12. This hypothesis is supported by the high saturations at MP3, MP6 , MP9 and MP12 in the upper part of the aquifer (3 to 4 m BGS) and low

  14. Fireman's Air Tanks

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Together with NASA's Johnson Space Center, A-T-O Inc.'s Scott Aviation has developed light-weight firefighter's air tanks. New backpack system weighs only 20 pounds for 30 minute air supply, 13 pounds less than conventional firefighting tanks. They are pressurized at 4,500 psi, (twice current tanks). Made of aluminum liner wrapped by resin-impregnated glass fibers, eliminating corrosion as well as lightening the load. Redesigned face mask permits better vision. Warning device to tell fireman he is running out of air is personalized so it can't be heard by others reducing confusion in an already hectic environment. Structural Composites Inc., The Boeing Co., and Martin- Marietta Corp. have developed uses for this technology.

  15. Liquid air cycle engines

    NASA Technical Reports Server (NTRS)

    Rosevear, Jerry

    1992-01-01

    Given here is a definition of Liquid Air Cycle Engines (LACE) and existing relevant technologies. Heat exchanger design and fabrication techniques, the handling of liquid hydrogen to achieve the greatest heat sink capabilities, and air decontamination to prevent heat exchanger fouling are discussed. It was concluded that technology needs to be extended in the areas of design and fabrication of heat exchangers to improve reliability along with weight and volume reductions. Catalysts need to be improved so that conversion can be achieved with lower quantities and lower volumes. Packaging studies need to be investigated both analytically and experimentally. Recycling with slush hydrogen needs further evaluation with experimental testing.

  16. Air Sampling Filter

    NASA Technical Reports Server (NTRS)

    1980-01-01

    General Metal Works' Accu-Vol is a high-volume air sampling system used by many government agencies to monitor air quality for pollution control purposes. Procedure prevents possible test-invalidating contamination from materials other than particulate pollutants, caused by manual handling or penetration of windblown matter during transit, a cassette was developed in which the filter is sealed within a metal frame and protected in transit by a snap-on aluminum cover, thus handled only under clean conditions in the laboratory.

  17. Dental Compressed Air Systems.

    DTIC Science & Technology

    1992-03-01

    I AL-TR-IWI-0uuu AD-A249 954 DENTAL COMPRESSED AIMYTM R Curtis D. Weyrmuch, Mejor, USAP, D Samuel P.Dvs iueatclpi SF.O N AEROSPACE MwaEDIN mwr~ComA G...FUNDING NUMBERS Dental Compressed Air Systems PE - 87714F PR - 7350 TA - 22 D. Weyrauch WU - XX Samuel P. Davis George W. Gaines 7. PERFORMING...words) The purpose of this report is to update guidelines on dental compressed air systems (DCA). Much of the information was obtained from a survey

  18. AIR Model Preflight Analysis

    NASA Technical Reports Server (NTRS)

    Tai, H.; Wilson, J. W.; Maiden, D. L.

    2003-01-01

    The atmospheric ionizing radiation (AIR) ER-2 preflight analysis, one of the first attempts to obtain a relatively complete measurement set of the high-altitude radiation level environment, is described in this paper. The primary thrust is to characterize the atmospheric radiation and to define dose levels at high-altitude flight. A secondary thrust is to develop and validate dosimetric techniques and monitoring devices for protecting aircrews. With a few chosen routes, we can measure the experimental results and validate the AIR model predictions. Eventually, as more measurements are made, we gain more understanding about the hazardous radiation environment and acquire more confidence in the prediction models.

  19. MSFC hot air collectors

    NASA Technical Reports Server (NTRS)

    Anthony, K.

    1978-01-01

    A description of the hot air collector is given that includes a history of development, a history of the materials development, and a program summary. The major portion of the solar energy system cost is the collector. Since the collector is the heart of the system and the most costly subsystem, reducing the cost of producing collectors in large quantities is a major goal. This solar collector is designed to heat air and/or water cheaply and efficiently through the use of solar energy.

  20. Space Derived Air Monitor

    NASA Technical Reports Server (NTRS)

    1983-01-01

    COPAMS, Commonwealth of Pennsylvania Air Monitoring System, derives from technology involved in building unmanned spacecraft. The Nimbus spacecraft carried experimental sensors to measure temperature, pressure, ozone, and water vapor, and instruments for studying solar radiation and telemetry. The process which relayed these findings to Earth formed the basis for COPAMS. The COPAMS system consists of data acquisition units which measure and record pollution level, and sense wind speed and direction, etc. The findings are relayed to a central station where the information is computerized. The system is automatic and supplemented by PAQSS, PA Air Quality Surveillance System.

  1. Air quality risk management.

    PubMed

    Williams, Martin L

    2008-01-01

    Rather than attempt to provide a comprehensive account of air quality risk assessment, as might be found in a textbook or manual, this article discusses some issues that are of current importance in the United Kingdom and the rest of Europe, with special emphasis on risk assessment in the context of policy formulation, and emerging scientific knowledge. There are two pollutants of particular concern and that both pose challenges for risk assessment and policy, and they are particulate matter (PM) and ozone. The article describes some issues for health risk assessment and finally some forward-looking suggestions for future approaches to air quality management.

  2. Tribal Air Quality Monitoring.

    ERIC Educational Resources Information Center

    Wall, Dennis

    2001-01-01

    The Institute for Tribal Environmental Professionals (ITEP) (Flagstaff, Arizona) provides training and support for tribal professionals in the technical job skills needed for air quality monitoring and other environmental management tasks. ITEP also arranges internships, job placements, and hands-on training opportunities and supports an…

  3. Air Proportional Counter

    DOEpatents

    Simpson, Jr, J A

    1950-12-05

    A multiple wire counter utilizing air at atmospheric pressure as the ionizing medium and having a window of a nylon sheet of less than 0.5 mil thickness coated with graphite. The window is permeable to alpha particles so that the counter is well adapted to surveying sources of alpha radiation.

  4. Immunotoxicity of air pollutants

    SciTech Connect

    Graham, J.A.; Gardner, D.E.

    1984-01-01

    The most common ubiquitous air pollutants, as well as some point source (e.g. metals) air pollutants, decrease the function of pulmonary host defense mechanisms against infection. Most of this knowledge is based on animal studies and involves cellular antibacterial defenses such as alveolar macrophages and mucociliary clearance. Information on viral infectivity is more sparse. Since there is no routine treatment for viral infections which have a relatively high rate of occurrence, this gap in knowledge is of concern. Given the major gaps in knowledge, resaonably accurate assessment of the immunotoxicity of air pollutants is not possible. When the limited data base is reviewed relative to ambient levels of the common pollutants, it appears that acute exposures to O3 and H2SO4 and chronic exposures to NO2 are the major exposures of concern for immunotoxic effects. It is critical to point out, however, that until information is available for chronic exposures to low levels of metals and for exposures to common organic vapors, the immunotoxicity of air pollutants cannot be assessed adequately.

  5. [Forward medical air evacuation].

    PubMed

    Czerniak, Erik; Le Dorze, Patrick Causse; Hersan, Olivier; Pohl, Jean-Baptiste; Angot, Emmanuel

    2014-09-01

    The medical chain which assures the treatment of casualties from the theatre of operations back to France comprises several links connected by medical air transport. Whether it is tactical or strategic, it forms an integral part of the treatment pathway and offers casualties the best possible conditions for medical treatment with a high degree of safety, speed and traceability.

  6. Ames Air Revitalization

    NASA Technical Reports Server (NTRS)

    Huang, Roger Z.

    2015-01-01

    This is an informal presentation presented to the University of Colorado, Boulder Bioastronautics group seminar. It highlights the key focal areas of the Air Revitalization Group research over the past year, including progress on the CO2 Removal and Compression System, testing of CDRA drying bed configurations, and adsorption research.

  7. The Air up There

    ERIC Educational Resources Information Center

    Thomas, Jeffrey

    2010-01-01

    To engage students in a real-world issue (Bransford, Brown, and Cocking 2000) that affects their communities, the author designed an entire unit to investigate air pollution in their home state, Connecticut. The unit's goal is to understand how the use of resources, such as fossil fuels, might affect their quality of life. Through this unit,…

  8. Air weapon fatalities.

    PubMed Central

    Milroy, C M; Clark, J C; Carter, N; Rutty, G; Rooney, N

    1998-01-01

    AIMS: To describe characteristics of a series of people accidentally and deliberately killed by air powered weapons. METHODS: Five cases of fatal airgun injury were identified by forensic pathologists and histopathologists. The circumstances surrounding the case, radiological examination, and pathological findings are described. The weapon characteristics are also reported. RESULTS: Three of the victims were adult men, one was a 16 year old boy, and one an eight year old child. Four of the airguns were .22 air rifles, the other a .177 air rifle. Two committed suicide, one person shooting himself in the head, the other in the chest. In both cases the guns were fired at contact range. Three of the cases were classified as accidents: in two the pellet penetrated into the head and in one the chest. CONCLUSIONS: One person each year dies from an air powered weapon injury in the United Kingdom. In addition there is considerable morbidity from airgun injuries. Fatalities and injuries are most commonly accidents, but deliberately inflicted injuries occur. Airguns are dangerous weapons when inappropriately handled and should not be considered as toys. Children should not play with airguns unsupervised. Images PMID:9797730

  9. Air Travel Health Tips

    MedlinePlus

    ... improved health Before your flightOne key to air travel is to prepare ahead of time. If you are carrying on a bag, make ... need to change if your eating and sleeping times will change at your destination.If you have diabetes or epilepsy, you should travel with your ID card. For instance, the American ...

  10. Air Blast Calculations

    DTIC Science & Technology

    2013-07-01

    library. A Jones-Wilkins-Lee (JWL) equation of state is used for each explosive considered, and a Sesame tabular equation of state is used to model the...explosives investigated (TNT, C4, PBXN-109, and NM) and the CTH material library parameters were used for each. Air was modeled using the Sesame tabular

  11. AIR POLLUTION AND HUMMINGBIRDS

    EPA Science Inventory

    A multidisciplinary team of EPA-RTP ORD pulmonary toxicologists, engineers, ecologists, and statisticians have designed a study of how ground-level ozone and other air pollutants may influence feeding activity of the ruby-throated hummingbird (Archilochus colubris). Be...

  12. The air afterglow revisited

    NASA Technical Reports Server (NTRS)

    Kaufman, F.

    1972-01-01

    The air afterglow, 0 + NO2 chemiluminescence, is discussed in terms of fluorescence, photodissociation, and quantum theoretical calculations of NO2. The experimental results presented include pressure dependence, M-dependence, spectral dependence of P and M, temperature dependence, and infrared measurements. The NO2 energy transfer model is also discussed.

  13. Clean Air by Design.

    ERIC Educational Resources Information Center

    Crawford, Gary N.

    1995-01-01

    Planning new construction is an opportunity to recognize indoor environmental quality (IEQ) issues. Provides an overview of some common IEQ issues associated with construction projects. A building's heating, ventilating, and air-conditioning (HVAC) system is by far the single most common cause of IEQ problems and complaints. (MLF)

  14. Air Pollution Surveillance Systems

    ERIC Educational Resources Information Center

    Morgan, George B.; And Others

    1970-01-01

    Describes atmospheric data monitoring as part of total airpollution control effort. Summarizes types of gaseous, liquid and solid pollutants and their sources; contrast between urban and rural environmental air quality; instrumentation to identify pollutants; and anticipated new non-wet chemical physical and physiochemical techniques tor cetection…

  15. Wartime Air Traffic Control

    DTIC Science & Technology

    1991-05-01

    sets overboard mnd reported their accidental loss.5 Fortunately. such aviation pioneers as Lt Col Henry H. ("Hap") Arnold and Capt Harold M. McClelland...operability is t he responsibility of the entire base populace. All "blue- suiters " must be mentally and physically prepared to fight the air base war. Winston

  16. Air-Supported Structures.

    ERIC Educational Resources Information Center

    Ontario Dept. of Education, Toronto. School Planning and Building Research Section.

    This study has been prepared to set out some of the benefits and the problems involved in the use of air-supported structures. Also indicated are the types of inquiries that should be made when the use of such structures is being considered. Technical and engineering details, such as the properties of various fabrics, are not included. (Author)

  17. Understanding Our Environment: Air.

    ERIC Educational Resources Information Center

    DiSpezio, Michael

    Part of the Understanding Our Environment project that is designed to engage students in investigating specific environmental problems through concrete activities and direct experience, this unit uses the contemporary dilemma of acid rain as a vehicle for teaching weather and the characteristics of air and atmosphere. The project involves a…

  18. Sticking with air

    SciTech Connect

    Coker, S.N.

    2005-06-01

    A decision to replace more than 300 aging damper actuators at Independence Plant in Newark, Arkensas forced Entergy to make a choice between pneumatic and electric actuator designs. The dampers route air flow through separate dedicated compartments to ensure proper firing of pulverised coal. The reasons that pneumatics was chosen are discussed in this article. 4 figs.

  19. Images in the Air

    ERIC Educational Resources Information Center

    Riveros, H. G.; Rosenberger, Franz

    2012-01-01

    This article discusses two "magic tricks" in terms of underlying optical principles. The first trick is new and produces a "ghost" in the air, and the second is the classical real image produced with two parabolic mirrors. (Contains 2 figure and 6 photos.)

  20. Oregon Air Ambulance Services.

    DTIC Science & Technology

    1986-01-01

    A 85 aboard unpressurized aircraft. These two patients, both of whom suffered from a bowel obstruction , were transported aboard unpressurized...services can safely transport patients with conditions (i.e. bowel obstruction , facial fractures, pneumothorax, intracranial air) which are clearly

  1. Comparing toxic air pollutant programs

    SciTech Connect

    Hawkins, S.C.

    1997-05-01

    This article compares state and federal toxic air pollutant programs. The Clean Air Act Ammendments created a program for the control of Hazardous Air Pollutants based on the establishment of control technology standards. State toxic programs can be classified into two categories: control technology-based and ambient concentration-based. Many states have opened to implement the MACT standards while enforcing their own state air toxics programs. Specific topics discussed include the following: the Federal air toxics program; existing state regulations; New Jersey Air Toxic Program; New York Toxics program.

  2. Air quality management in Mexico.

    PubMed

    Fernández-Bremauntz, Adrián

    2008-01-01

    Several significant program and policy measures have been implemented in Mexico over the past 15 yr to improve air quality. This article provides an overview of air quality management strategies in Mexico, including (1) policy initiatives such as vehicle use restrictions, air quality standards, vehicle emissions, and fuel quality standards, and (2) supporting programs including establishment of a national emission inventory, an air pollution episodes program, and the implementation of exposure and health effects studies. Trends in air pollution episodes and ambient air pollutant concentrations are described.

  3. Care for Your Air: A Guide to Indoor Air Quality

    EPA Pesticide Factsheets

    Understand indoor air in homes, schools, and offices. Most of us spend much of our time indoors. The air that we breathe in our homes, in schools, and in offices can put us at risk for health problems.

  4. Alaskan Air Defense and Early Warning Systems Clear Air ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Alaskan Air Defense and Early Warning Systems - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  5. Air-Coupled Vibrometry

    NASA Astrophysics Data System (ADS)

    Döring, D.; Solodov, I.; Busse, G.

    Sound and ultrasound in air are the products of a multitude of different processes and thus can be favorable or undesirable phenomena. Development of experimental tools for non-invasive measurements and imaging of airborne sound fields is of importance for linear and nonlinear nondestructive material testing as well as noise control in industrial or civil engineering applications. One possible solution is based on acousto-optic interaction, like light diffraction imaging. The diffraction approach usually requires a sophisticated setup with fine optical alignment barely applicable in industrial environment. This paper focuses on the application of the robust experimental tool of scanning laser vibrometry, which utilizes commercial off-the-shelf equipment. The imaging technique of air-coupled vibrometry (ACV) is based on the modulation of the optical path length by the acoustic pressure of the sound wave. The theoretical considerations focus on the analysis of acousto-optical phase modulation. The sensitivity of the ACV in detecting vibration velocity was estimated as ~1 mm/s. The ACV applications to imaging of linear airborne fields are demonstrated for leaky wave propagation and measurements of ultrasonic air-coupled transducers. For higher-intensity ultrasound, the classical nonlinear effect of the second harmonic generation was measured in air. Another nonlinear application includes a direct observation of the nonlinear air-coupled emission (NACE) from the damaged areas in solid materials. The source of the NACE is shown to be strongly localized around the damage and proposed as a nonlinear "tag" to discern and image the defects.

  6. 17. VIEW OF AIR LOCK ENTRY DOOR. BANKS OF AIR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. VIEW OF AIR LOCK ENTRY DOOR. BANKS OF AIR FILTERS ARE VISIBLE TO THE SIDES OF THE DOORS. THE BUILDING WAS DIVIDED INTO ZONES BY AIRLOCK DOORS AND AIR FILTERS. AIR PRESSURE DIFFERENTIALS WERE MAINTAINED IN THE ZONES, SUCH THAT AIRFLOW WAS PROGRESSIVELY TOWARD AREAS WITH THE HIGHEST POTENTIAL FOR CONTAMINATION. (9/24/91) - Rocky Flats Plant, Plutonium Manufacturing Facility, North-central section of Plant, just south of Building 776/777, Golden, Jefferson County, CO

  7. 26. "AIR INSTALLATIONS; EDWARDS AIR FORCE BASE, CALIFORNIA; HIGH SPEED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. "AIR INSTALLATIONS; EDWARDS AIR FORCE BASE, CALIFORNIA; HIGH SPEED TEST TRACK." Drawing No. 10-259. One inch to 400 feet plan of original 10,000-foot sled track. No date. No D.O. series number. No headings as above. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

  8. Something in the Air: Air Pollution in Schools.

    ERIC Educational Resources Information Center

    Villaire, Ted

    2002-01-01

    Discusses the danger of unhealthy air in the school environment, describing common problems and how parents and schools can respond. The article focuses on the dangers of mold, pesticides, diesel exhaust, and radon. The three sidebars describe how to promote indoor air quality at school, note how to determine whether the school's air is making…

  9. A Breath of Fresh Air: Addressing Indoor Air Quality

    ERIC Educational Resources Information Center

    Palliser, Janna

    2011-01-01

    Indoor air pollution refers to "chemical, biological, and physical contamination of indoor air," which may result in adverse health effects (OECD 2003). The causes, sources, and types of indoor air pollutants will be addressed in this article, as well as health effects and how to reduce exposure. Learning more about potential pollutants in home…

  10. Indoor Air Quality in Schools: Clean Air Is Good Business.

    ERIC Educational Resources Information Center

    Guarneiri, Michele A.

    2003-01-01

    Describes the effect of poor indoor air quality (IAQ) on student health, the cost of safeguarding good IAQ, the cause of poor IAQ in schools, how to tell whether a school has an IAQ problem, and how the U.S. Environmental Protection Agency can help schools improve indoor air quality though the use of their free "Indoor Air Quality Tools for…

  11. Properties of air and combustion products of fuel with air

    NASA Technical Reports Server (NTRS)

    Poferl, D. J.; Svehla, R. A.

    1975-01-01

    Thermodynamic and transport properties have been calculated for air, the combustion products of natural gas and air, and combustion products of ASTM-A-1 jet fuel and air. Properties calculated include: ratio of specific heats, molecular weight, viscosity, specific heat, thermal conductivity, Prandtl number, and enthalpy.

  12. Air-cooled, hydrogen-air fuel cell

    NASA Technical Reports Server (NTRS)

    Shelekhin, Alexander B. (Inventor); Bushnell, Calvin L. (Inventor); Pien, Michael S. (Inventor)

    1999-01-01

    An air-cooled, hydrogen-air solid polymer electrolyte (SPE) fuel cell with a membrane electrode assembly operatively associated with a fluid flow plate having at least one plate cooling channel extending through the plate and at least one air distribution hole extending from a surface of the cathode flow field into the plate cooling channel.

  13. State of the Air 2015

    MedlinePlus

    ... USA Information for Citizens and Communities National Ambient Air Quality Standards Protect the Environment: Act Locally What You Can Do Healthy Air News Facebook Twitter Google Plus Instagram © American Lung ...

  14. Air Emissions Monitoring for Permits

    EPA Pesticide Factsheets

    Operating permits document how air pollution sources will demonstrate compliance with emission limits and also how air pollution sources will monitor, either periodically or continuously, their compliance with emission limits and all other requirements.

  15. Air Emissions Factors and Quantification

    EPA Pesticide Factsheets

    Emissions factors are used in developing air emissions inventories for air quality management decisions and in developing emissions control strategies. This area provides technical information on and support for the use of emissions factors.

  16. Air Mobile Utility Distribution Systems.

    DTIC Science & Technology

    WATER PIPES, AIR TRANSPORTABLE EQUIPMENT, POLYVINYL CHLORIDE, GLASS REINFORCED PLASTICS , FUEL HOSES, HOSES....PIPES, *PIPING SYSTEMS, INSULATION, FABRICATION, CORROSION INHIBITION, FEASIBILITY STUDIES, AIR FORCE FACILITIES, POLYURETHANE RESINS, PLASTICS

  17. Clean Air Technology Center Products

    EPA Pesticide Factsheets

    The Clean Air Technology Center provides resources for emerging and existing air pollution prevention and control technologies and provides public access to data and information on their use, effectiveness and cost.

  18. Air Pollution over the States

    ERIC Educational Resources Information Center

    Environmental Science and Technology, 1972

    1972-01-01

    State plans for implementing air quality standards are evaluated together with problems in modeling procedures and enforcement. Monitoring networks, standards, air quality regions, and industrial problems are also discussed. (BL)

  19. EPA Activities for Cleaner Air

    EPA Pesticide Factsheets

    Activities in San Joaquin Valley to reduce air pollution, meet federal health standards for ozone and particulates, fund clean tech and health research, and enforce compliance with facility-specific operating permits for industrial air pollution sources.

  20. Metal-air battery assessment

    SciTech Connect

    Sen, R.K.; Van Voorhees, S.L.; Ferrel, T.

    1988-05-01

    The objective of this report is to evaluate the present technical status of the zinc-air, aluminum/air and iron/air batteries and assess their potential for use in an electric vehicle. In addition, this report will outline proposed research and development priorities for the successful development of metal-air batteries for electric vehicle application. 39 refs., 25 figs., 11 tabs.

  1. Iron-Air Rechargeable Battery

    NASA Technical Reports Server (NTRS)

    Narayan, Sri R. (Inventor); Prakash, G.K. Surya (Inventor); Kindler, Andrew (Inventor)

    2014-01-01

    Embodiments include an iron-air rechargeable battery having a composite electrode including an iron electrode and a hydrogen electrode integrated therewith. An air electrode is spaced from the iron electrode and an electrolyte is provided in contact with the air electrode and the iron electrodes. Various additives and catalysts are disclosed with respect to the iron electrode, air electrode, and electrolyte for increasing battery efficiency and cycle life.

  2. Basic Information about Air Emissions Monitoring

    EPA Pesticide Factsheets

    This site is about types of air emissions monitoring and the Clean Air Act regulations, including Ambient Air Quality Monitoring, Stationary Source Emissions Monitoring, and Continuous Monitoring Systems.

  3. Air pollution from aircraft

    NASA Technical Reports Server (NTRS)

    Heywood, J. B.; Fay, J. A.; Chigier, N. A.

    1979-01-01

    Forty-one annotated abstracts of reports generated at MIT and the University of Sheffield are presented along with summaries of the technical projects undertaken. Work completed includes: (1) an analysis of the soot formation and oxidation rates in gas turbine combustors, (2) modelling the nitric oxide formation process in gas turbine combustors, (3) a study of the mechanisms causing high carbon monoxide emissions from gas turbines at low power, (4) an analysis of the dispersion of pollutants from aircraft both around large airports and from the wakes of subsonic and supersonic aircraft, (5) a study of the combustion and flow characteristics of the swirl can modular combustor and the development and verification of NO sub x and CO emissions models, (6) an analysis of the influence of fuel atomizer characteristics on the fuel-air mixing process in liquid fuel spray flames, and (7) the development of models which predict the stability limits of fully and partially premixed fuel-air mixtures.

  4. Aeromicrobiology/air quality

    USGS Publications Warehouse

    Andersen, Gary L.; Frisch, A.S.; Kellogg, Christina A.; Levetin, E.; Lighthart, Bruce; Paterno, D.

    2009-01-01

    The most prevalent microorganisms, viruses, bacteria, and fungi, are introduced into the atmosphere from many anthropogenic sources such as agricultural, industrial and urban activities, termed microbial air pollution (MAP), and natural sources. These include soil, vegetation, and ocean surfaces that have been disturbed by atmospheric turbulence. The airborne concentrations range from nil to great numbers and change as functions of time of day, season, location, and upwind sources. While airborne, they may settle out immediately or be transported great distances. Further, most viable airborne cells can be rendered nonviable due to temperature effects, dehydration or rehydration, UV radiation, and/or air pollution effects. Mathematical microbial survival models that simulate these effects have been developed.

  5. Air cathode structure manufacture

    DOEpatents

    Momyer, William R.; Littauer, Ernest L.

    1985-01-01

    An improved air cathode structure for use in primary batteries and the like. The cathode structure includes a matrix active layer, a current collector grid on one face of the matrix active layer, and a porous, nonelectrically conductive separator on the opposite face of the matrix active layer, the collector grid and separator being permanently bonded to the matrix active layer. The separator has a preselected porosity providing low IR losses and high resistance to air flow through the matrix active layer to maintain high bubble pressure during operation of the battery. In the illustrated embodiment, the separator was formed of porous polypropylene. A thin hydrophobic film is provided, in the preferred embodiment, on the current collecting metal grid.

  6. FLUIDIC: Metal Air Recharged

    ScienceCinema

    Friesen, Cody

    2016-07-12

    Fluidic, with the help of ARPA-E funding, has developed and deployed the world's first proven high cycle life metal air battery. Metal air technology, often used in smaller scale devices like hearing aids, has the lowest cost per electron of any rechargeable battery storage in existence. Deploying these batteries for grid reliability is competitive with pumped hydro installations while having the advantages of a small footprint. Fluidic's battery technology allows utilities and other end users to store intermittent energy generated from solar and wind, as well as maintain reliable electrical delivery during power outages. The batteries are manufactured in the US and currently deployed to customers in emerging markets for cell tower reliability. As they continue to add customers, they've gained experience and real world data that will soon be leveraged for US grid reliability.

  7. FLUIDIC: Metal Air Recharged

    SciTech Connect

    Friesen, Cody

    2014-03-07

    Fluidic, with the help of ARPA-E funding, has developed and deployed the world's first proven high cycle life metal air battery. Metal air technology, often used in smaller scale devices like hearing aids, has the lowest cost per electron of any rechargeable battery storage in existence. Deploying these batteries for grid reliability is competitive with pumped hydro installations while having the advantages of a small footprint. Fluidic's battery technology allows utilities and other end users to store intermittent energy generated from solar and wind, as well as maintain reliable electrical delivery during power outages. The batteries are manufactured in the US and currently deployed to customers in emerging markets for cell tower reliability. As they continue to add customers, they've gained experience and real world data that will soon be leveraged for US grid reliability.

  8. Air Pollution Primer. Revised Education.

    ERIC Educational Resources Information Center

    Corman, Rena

    This revised and updated book is written to inform the citizens on the nature, causes, and effects of air pollution. It is written in terms familiar to the layman with the purpose of providing knowledge and motivation to spur community action on clean air policies. Numerous charts and drawings are provided to support discussion of air pollution…

  9. Next-generation air monitoring

    EPA Science Inventory

    Air pollution measurement technology is advancing rapidly towards smaller-scale and wireless devices, with a potential to significantly change the landscape of air pollution monitoring. EPA is evaluating and developing a range of next-generation air monitoring (NGAM) technologie...

  10. Indoor Air Quality in Schools.

    ERIC Educational Resources Information Center

    Torres, Vincent M.

    Asserting that the air quality inside schools is often worse than outdoor pollution, leading to various health complaints and loss of productivity, this paper details factors contributing to schools' indoor air quality. These include the design, operation, and maintenance of heating, ventilating, and air conditioning (HVAC) systems; building…

  11. AIR STRUCTURES FOR SCHOOL SPORTS.

    ERIC Educational Resources Information Center

    ROBERTSON, NAN

    AIR STRUCTURES ARE FABRIC BUILDINGS BLOWN UP AND HELD UP BY AIR PRESSURE. EXPERIMENTS WITH SUCH STRUCTURES WERE CONDUCTED AS EARLY AS 1917. IN 1948 THE UNITED STATES AIR FORCE SOUGHT A NEW WAY OF HOUSING LARGE RADAR ANTENNAE PLANNED FOR THE ARCTIC. AS AN OUTCOME OF THEIR SEARCH, BIRDAIR STRUCTURES, INC., WHICH IS NOW ONE OF SEVERAL COMPANIES…

  12. Air Structures for School Sports.

    ERIC Educational Resources Information Center

    Robertson, Nan

    Air structures are fabric buildings blown up and held up by air pressure. Experiments with such structures were conducted as early as 1917. In 1948 the United States Air Force sought a new way of housing large radar antennae planned for the arctic. As an outcome of their search, Birdair Structures, Inc., which is now one of several companies…

  13. Improving IAQ Via Air Filtration.

    ERIC Educational Resources Information Center

    Monk, Brian

    1999-01-01

    Provides tips on using air filtration to control indoor air quality in educational facilities, including dedicated spaces with unique air quality conditions such as in libraries, museums and archival storage areas, kitchens and dining areas, and laboratories. The control of particulate contaminants, gaseous contaminants, and moisture buildup are…

  14. Pupils' Understanding of Air Pollution

    ERIC Educational Resources Information Center

    Dimitriou, Anastasia; Christidou, Vasilia

    2007-01-01

    This paper reports on a study of pupils' knowledge and understanding of atmospheric pollution. Specifically, the study is aimed at identifying: 1) the extent to which pupils conceptualise the term "air pollution" in a scientifically appropriate way; 2) pupils' knowledge of air pollution sources and air pollutants; and 3) pupils'…

  15. Overview of Emerging Air Sensors

    EPA Science Inventory

    These slides will be presented at the 2014 National Ambient Air Monitoring Conference in Atlanta, GA during August 11-15, 2014. The goal is to provide an overview of air sensor technology and the audience will be primarily state air monitoring agencies and EPA Regions.

  16. Improved high volume air sampler

    NASA Technical Reports Server (NTRS)

    King, R. B.

    1974-01-01

    Sampler permits size separations of particles by directing sampled air through cross-sectional area sufficiently large that air velocity is reduced to point where particles or larger size will settle out. Sampler conducts air downward and through slots around periphery of unit into relatively open interior of house.

  17. Air Quality System (AQS) Metadata

    EPA Pesticide Factsheets

    The U.S. Environmental Protection Agency compiles air quality monitoring data in the Air Quality System (AQS). Ambient air concentrations are measured at a national network of more than 4,000 monitoring stations and are reported by state, local, and tribal

  18. Air Pollution, Causes and Cures.

    ERIC Educational Resources Information Center

    Manufacturing Chemists Association, Washington, DC.

    This commentary on sources of air pollution and air purification treatments is accompanied by graphic illustrations. Sources of carbon monoxide, sulfur oxides, nitrogen oxides, and hydrocarbons found in the air are discussed. Methods of removing these pollutants at their source are presented with cut-away diagrams of the facilities and technical…

  19. Congress and the Air Force.

    DTIC Science & Technology

    1996-04-01

    know where to go to find out that information. The "Congress and the Air Force" Internet web page serves as a " one - stop shop" where Air Force personnel...Congress. The need for a " one - stop " guide is clear. The literature on this topic is not readily accessible by the Air Force member out in the field who

  20. Transpired Air Collectors - Ventilation Preheating

    SciTech Connect

    Christensen, C.

    2006-06-22

    Many commercial and industrial buildings have high ventilation rates. Although all that fresh air is great for indoor air quality, heating it can be very expensive. This short (2-page) fact sheet describes a technology available to use solar energy to preheat ventilation air and dramatically reduce utility bills.

  1. Air Conditioning Overflow Sensor

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Technology Transfer Office at Stennis Space Center helped a local inventor develop a prototype of an attachment for central air conditioners and heat pumps that helps monitor water levels to prevent condensation overflow. The sensor will indicate a need for drain line maintenance and prevent possible damage caused by drain pan water spillover. An engineer in the Stennis Space Center prototype Development Laboratory used SSC sensor technology in the development of the sensor.

  2. The AIRES Optical Design

    NASA Technical Reports Server (NTRS)

    Haas, Michael R.; DeVincenzi, Donald L. (Technical Monitor)

    2001-01-01

    AIRES (Airborne InfraRed Echelle Spectrometer) is the facility spectrometer for SOFIA (Stratospheric Observatory For Infrared Astronomy). AIRES is a long-slit (approximately 160 in) spectrometer designed to cover the 17 to 210-micron range with good sensitivity using three spectroscopic arrays. Initially, only the 30-130 micron, mid-wavelength array will be available. The instrument has a cryogenic K-mirror to perform field rotation and a slit-viewing camera (lambda < 28 microns, FOV = 160 in diameter) to image source morphology and verify telescope pointing. AIRES employs a large echelle grating to achieve a spectral resolving power (lambda/delta lambda) of approximately 1.0 x 10(exp 6)/lambda (sub mu), where lambda (sub mu) is the wavelength in microns. Hyperfine, Inc. has ruled and tested the AIRES' echelle; its wave-front error is 0.028 waves RMS (root mean square) at 10.6 microns. The instrument is housed in a liquid-helium cryostat which is constrained in diameter (approximately 1 m) and length (approximately 2 m) by the observatory. Hence, the length of the echelle (approximately 1.1 m) and the focal length of its collimator (approximately 5.2 m) severely drive the optical design and packaging. The final design uses diamond-turned aluminum optics and has up to 19 reflections inside the cryostat, depending on the optical path. This design was generated, optimized, and toleranced using Code V. The predicted performance is nearly diffraction-limited at 17 microns; the error budget is dominated by design residuals. Light loss due to slit rotation and slit curvature has been minimized. A thorough diffraction analysis with GLAD (G-Level Analysis Drawer) was used to size the mirrors and baffles; the internal light loss is shown to be a strong function of slit width.

  3. Urban air quality

    NASA Astrophysics Data System (ADS)

    Fenger, Jes

    Since 1950 the world population has more than doubled, and the global number of cars has increased by a factor of 10. In the same period the fraction of people living in urban areas has increased by a factor of 4. In year 2000 this will amount to nearly half of the world population. About 20 urban regions will each have populations above 10 million people. Seen over longer periods, pollution in major cities tends to increase during the built up phase, they pass through a maximum and are then again reduced, as abatement strategies are developed. In the industrialised western world urban air pollution is in some respects in the last stage with effectively reduced levels of sulphur dioxide and soot. In recent decades however, the increasing traffic has switched the attention to nitrogen oxides, organic compounds and small particles. In some cities photochemical air pollution is an important urban problem, but in the northern part of Europe it is a large-scale phenomenon, with ozone levels in urban streets being normally lower than in rural areas. Cities in Eastern Europe have been (and in many cases still are) heavily polluted. After the recent political upheaval, followed by a temporary recession and a subsequent introduction of new technologies, the situation appears to improve. However, the rising number of private cars is an emerging problem. In most developing countries the rapid urbanisation has so far resulted in uncontrolled growth and deteriorating environment. Air pollution levels are here still rising on many fronts. Apart from being sources of local air pollution, urban activities are significant contributors to transboundary pollution and to the rising global concentrations of greenhouse gasses. Attempts to solve urban problems by introducing cleaner, more energy-efficient technologies will generally have a beneficial impact on these large-scale problems. Attempts based on city planning with a spreading of the activities, on the other hand, may generate

  4. Air regenerating and conditioning

    NASA Technical Reports Server (NTRS)

    Grishayenkov, B. G.

    1975-01-01

    Various physicochemical methods of regenerating and conditioning air for spacecraft are described with emphasis on conditions which affect efficiency of the system. Life support systems used in closed, hermetically sealed environments are discussed with references to actual application in the Soviet Soyuz and Voskhod manned spacecraft. Temperature and humidity control, removal of carbon dioxide, oxygen regeneration, and removal of bacteria and viruses are among the factors considered.

  5. Deployable Engine Air Brake

    NASA Technical Reports Server (NTRS)

    2014-01-01

    On approach, next-generation aircraft are likely to have airframe noise levels that are comparable to or in excess of engine noise. ATA Engineering, Inc. (ATA) is developing a novel quiet engine air brake (EAB), a device that generates "equivalent drag" within the engine through stream thrust reduction by creating a swirling outflow in the turbofan exhaust nozzle. Two Phase II projects were conducted to mature this technology: (1) a concept development program (CDP) and (2) a system development program (SDP).

  6. Enhancing indoor air quality –The air filter advantage

    PubMed Central

    Vijayan, Vannan Kandi; Paramesh, Haralappa; Salvi, Sundeep Santosh; Dalal, Alpa Anil Kumar

    2015-01-01

    Air pollution has become the world's single biggest environmental health risk, linked to around 7 million deaths in 2012 according to a recent World Health Organisation (WHO) report. The new data further reveals a stronger link between, indoor and outdoor air pollution exposure and cardiovascular diseases, such as strokes and ischemic heart disease, as well as between air pollution and cancer. The role of air pollution in the development of respiratory diseases, including acute respiratory infections and chronic obstructive pulmonary diseases, is well known. While both indoor and outdoor pollution affect health, recent statistics on the impact of household indoor pollutants (HAP) is alarming. The WHO factsheet on HAP and health states that 3.8 million premature deaths annually - including stroke, ischemic heart disease, chronic obstructive pulmonary disease (COPD) and lung cancer are attributed to exposure to household air pollution. Use of air cleaners and filters are one of the suggested strategies to improve indoor air quality. This review discusses the impact of air pollutants with special focus on indoor air pollutants and the benefits of air filters in improving indoor air quality. PMID:26628762

  7. Air transparent soundproof window

    NASA Astrophysics Data System (ADS)

    Kim, Sang-Hoon; Lee, Seong-Hyun

    2014-11-01

    A soundproof window or wall which is transparent to airflow is presented. The design is based on two wave theories: the theory of diffraction and the theory of acoustic metamaterials. It consists of a three-dimensional array of strong diffraction-type resonators with many holes centered on each individual resonator. The negative effective bulk modulus of the resonators produces evanescent wave, and at the same time the air holes with subwavelength diameter existed on the surfaces of the window for macroscopic air ventilation. The acoustic performance levels of two soundproof windows with air holes of 20mm and 50mm diameters were measured. The sound level was reduced by about 30 - 35dB in the frequency range of 400 - 5,000Hz with the 20mm window, and by about 20 - 35dB in the frequency range of 700 - 2,200Hz with the 50mm window. Multi stop-band was created by the multi-layers of the window. The attenuation length or the thickness of the window was limited by background noise. The effectiveness of the soundproof window with airflow was demonstrated by a real installation.

  8. Air transparent soundproof window

    SciTech Connect

    Kim, Sang-Hoon; Lee, Seong-Hyun

    2014-11-15

    A soundproof window or wall which is transparent to airflow is presented. The design is based on two wave theories: the theory of diffraction and the theory of acoustic metamaterials. It consists of a three-dimensional array of strong diffraction-type resonators with many holes centered on each individual resonator. The negative effective bulk modulus of the resonators produces evanescent wave, and at the same time the air holes with subwavelength diameter existed on the surfaces of the window for macroscopic air ventilation. The acoustic performance levels of two soundproof windows with air holes of 20mm and 50mm diameters were measured. The sound level was reduced by about 30 - 35dB in the frequency range of 400 - 5,000Hz with the 20mm window, and by about 20 - 35dB in the frequency range of 700 - 2,200Hz with the 50mm window. Multi stop-band was created by the multi-layers of the window. The attenuation length or the thickness of the window was limited by background noise. The effectiveness of the soundproof window with airflow was demonstrated by a real installation.

  9. Wind driven air pump

    SciTech Connect

    Beisel, V.A.

    1983-05-31

    An improved pump for lifting water from an underground source utilizes a wind motor for driving an oil-less air compressor eliminating oil contamination of ground water which is forced to the surface. The wind motor is movable to face the wind by means of a novel swivel assembly which also eliminates the formation and freezing of condensate within the airline from the compressor. The propeller blades of the wind motor and the tail section are formed from a pair of opposed convex air foil shaped surfaces which provide the propeller blades and the tail section with fast sensitivity to slight changes in wind direction and speed. A novel well tower for supporting the wind motor and compressor and for lifting the water from the underground source is an optional modification which requires no welding and eliminates the problem of condensate freezing in the airline going to the well. The wind driven air pump disclosed is lightweight, can be easily installed, is relatively inexpensive to produce and is virtually maintenance-free and capable of operating in winds exceeding 100 miles per hour.

  10. Air System Information Management

    NASA Technical Reports Server (NTRS)

    Filman, Robert E.

    2004-01-01

    I flew to Washington last week, a trip rich in distributed information management. Buying tickets, at the gate, in flight, landing and at the baggage claim, myriad messages about my reservation, the weather, our flight plans, gates, bags and so forth flew among a variety of travel agency, airline and Federal Aviation Administration (FAA) computers and personnel. By and large, each kind of information ran on a particular application, often specialized to own data formats and communications network. I went to Washington to attend an FAA meeting on System-Wide Information Management (SWIM) for the National Airspace System (NAS) (http://www.nasarchitecture.faa.gov/Tutorials/NAS101.cfm). NAS (and its information infrastructure, SWIM) is an attempt to bring greater regularity, efficiency and uniformity to the collection of stovepipe applications now used to manage air traffic. Current systems hold information about flight plans, flight trajectories, weather, air turbulence, current and forecast weather, radar summaries, hazardous condition warnings, airport and airspace capacity constraints, temporary flight restrictions, and so forth. Information moving among these stovepipe systems is usually mediated by people (for example, air traffic controllers) or single-purpose applications. People, whose intelligence is critical for difficult tasks and unusual circumstances, are not as efficient as computers for tasks that can be automated. Better information sharing can lead to higher system capacity, more efficient utilization and safer operations. Better information sharing through greater automation is possible though not necessarily easy.

  11. Biological air filter for air-quality control

    NASA Astrophysics Data System (ADS)

    van Ras, Niels; Krooneman, Janneke; Ogink, Nico; Willers, Hans; D'Amico, Arnaldo; di Natale, Corrado; Godia, F.; Albiol, J.; Perez, J.; Martinez, N.; Dixon, Mike; Llewellyn, David; Eckhard, Fir; Zona, G.; Fachecci, L.; Kraakman, Bart; Demey, Dries; Michel, Noelle; Darlington, Alan

    2005-10-01

    Biological air filtration is a promising technique for air-quality control in closed environments in space and on Earth, and it offers several advantages over existing techniques. However, to apply it in these environments, specific criteria have to be met. A concept for biological air filtration in closed environments was developed and tested by an international team of specialists. Several model systems for closed environments in space and on Earth were used as a source of contaminated air. Conventional and new analytical techniques were used to determine odour composition and removal efficiency of the filter, including an "electronic nose". The results show that the developed biological air filter is suitable for treating contaminated air in closed environments. The developed electronic nose was shown to be a promising method for air-quality monitoring.

  12. Solid-Sorbent Air Sampler

    NASA Technical Reports Server (NTRS)

    Galen, T. J.

    1986-01-01

    Portable unit takes eight 24-hour samples. Volatile organic compounds in air collected for analysis by portable, self-contained sampling apparatus. Sampled air drawn through sorbent material, commercial porous polymer of 2, 3-diphenyl-p-phenylene oxide. High-boiling-point organic compounds adsorbed onto polymer, while low-boiling-point organics pass through and returned to atmosphere. Sampler includes eight sample tubes filled with polymeric sorbent. Organic compounds in atmosphere absorbed when air pumped through sorbent. Designed for checking air in spacecraft, sampler adaptable to other applications as leak detection, gas-mixture analysis, and ambient-air monitoring.

  13. Air Risk Information Support Center

    SciTech Connect

    Shoaf, C.R.; Guth, D.J.

    1990-12-31

    The Air Risk Information Support Center (Air RISC) was initiated in early 1988 by the US Environmental Protection Agency`s (EPA) Office of Health and Environmental Assessment (OHEA) and the Office of Air Quality Planning and Standards (OAQPS) as a technology transfer effort that would focus on providing information to state and local environmental agencies and to EPA Regional Offices in the areas of health, risk, and exposure assessment for toxic air pollutants. Technical information is fostered and disseminated by Air RISCs three primary activities: (1) a {open_quotes}hotline{close_quotes}, (2) quick turn-around technical assistance projects, and (3) general technical guidance projects. 1 ref., 2 figs.

  14. Ozone, Air Quality, and Asthma (For Parents)

    MedlinePlus

    ... Feeding Your 1- to 2-Year-Old Ozone, Air Quality, and Asthma KidsHealth > For Parents > Ozone, Air Quality, ... can also affect lung function. continue How Poor Air Quality Affects People With Asthma Air pollution is a ...

  15. Community Multiscale Air Quality Modeling System (CMAQ)

    EPA Pesticide Factsheets

    CMAQ is a computational tool used for air quality management. It models air pollutants including ozone, particulate matter and other air toxics to help determine optimum air quality management scenarios.

  16. Remote air pollution measurement

    NASA Technical Reports Server (NTRS)

    Byer, R. L.

    1975-01-01

    This paper presents a discussion and comparison of the Raman method, the resonance and fluorescence backscatter method, long path absorption methods and the differential absorption method for remote air pollution measurement. A comparison of the above remote detection methods shows that the absorption methods offer the most sensitivity at the least required transmitted energy. Topographical absorption provides the advantage of a single ended measurement, and differential absorption offers the additional advantage of a fully depth resolved absorption measurement. Recent experimental results confirming the range and sensitivity of the methods are presented.

  17. Ambient Air Definition

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  18. Hot air drum evaporator

    DOEpatents

    Black, Roger L.

    1981-01-01

    An evaporation system for aqueous radioactive waste uses standard 30 and 55 gallon drums. Waste solutions form cascading water sprays as they pass over a number of trays arranged in a vertical stack within a drum. Hot dry air is circulated radially of the drum through the water sprays thereby removing water vapor. The system is encased in concrete to prevent exposure to radioactivity. The use of standard 30 and 55 gallon drums permits an inexpensive compact modular design that is readily disposable, thus eliminating maintenance and radiation build-up problems encountered with conventional evaporation systems.

  19. Solid sorbent air sampler

    NASA Astrophysics Data System (ADS)

    Galen, T. J.

    1986-04-01

    A fluid sampler for collecting a plurality of discrete samples over separate time intervals is described. The sampler comprises a sample assembly having an inlet and a plurality of discreet sample tubes each of which has inlet and outlet sides. A multiport dual acting valve is provided in the sampler in order to sequentially pass air from the sample inlet into the selected sample tubes. The sample tubes extend longitudinally of the housing and are located about the outer periphery thereof so that upon removal of an enclosure cover, they are readily accessible for operation of the sampler in an analysis mode.

  20. Regenerative air heater

    DOEpatents

    Hasselquist, P.B.; Baldner, R.

    1980-11-26

    A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

  1. Regenerative air heater

    DOEpatents

    Hasselquist, Paul B.; Baldner, Richard

    1982-01-01

    A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

  2. Ag-Air Service

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Econ, Inc.'s agricultural aerial application, "ag-air," involves more than 10,000 aircraft spreading insecticides, herbicides, fertilizer, seed and other materials over millions of acres of farmland. Difficult for an operator to estimate costs accurately and decide what to charge or which airplane can handle which assignment most efficiently. Computerized service was designed to improve business efficiency in choice of aircraft and determination of charge rates based on realistic operating cost data. Each subscriber fills out a detailed form which pertains to his needs and then receives a custom-tailored computer printout best suited to his particular business mix.

  3. Solid sorbent air sampler

    NASA Technical Reports Server (NTRS)

    Galen, T. J. (Inventor)

    1986-01-01

    A fluid sampler for collecting a plurality of discrete samples over separate time intervals is described. The sampler comprises a sample assembly having an inlet and a plurality of discreet sample tubes each of which has inlet and outlet sides. A multiport dual acting valve is provided in the sampler in order to sequentially pass air from the sample inlet into the selected sample tubes. The sample tubes extend longitudinally of the housing and are located about the outer periphery thereof so that upon removal of an enclosure cover, they are readily accessible for operation of the sampler in an analysis mode.

  4. Air gun wounding and current UK laws controlling air weapons.

    PubMed

    Bruce-Chwatt, Robert Michael

    2010-04-01

    Air weapons whether rifles or pistols are, potentially, lethal weapons. The UK legislation is complex and yet little known to the public. Hunting with air weapons and the laws controlling those animals that are permitted to be shot with air weapons is even more labyrinthine due to the legal power limitations on the possession of air weapons. Still relatively freely available by mail order or on the Internet, an increasing number of deaths have been reported from the misuse of air weapons or accidental discharges. Ammunition for air weapons has become increasingly sophisticated, effective and therefore increasingly dangerous if misused, though freely available being a mere projectile without a concomitant cartridge containing a propellant and an initiator.

  5. Air channel distribution during air sparging: A field experiment

    SciTech Connect

    Leeson, A.; Hinchee, R.E.; Headington, G.L.; Vogel, C.M.

    1995-12-31

    Air sparging may have the potential to improve upon conventional groundwater treatment technologies. However, judging from studies published to date and theoretical analyses, it is possible that air sparging may have a limited effect on aquifer contamination. The basic mechanisms controlling air sparging are not well understood, and current monitoring practice does not appear adequate to quantitatively evaluate the process. During this study, the effective zone of influence, defined as the areas in which air channels form, was studied as a function of flowrate and depth of injection points. This was accomplished by conducting the air sparging test in an area with shallow standing water. Air sparging points were installed at various depths, and the zone of influence was determined visually.

  6. Air modeling: Air dispersion models; regulatory applications and technological advances

    SciTech Connect

    Miller, M.; Liles, R.

    1995-09-01

    Air dispersion models are a useful and practical tool for both industry and regulatory agencies. They serve as tools for engineering, permitting, and regulations development. Their cost effectiveness and ease of implementation compared to ambient monitoring is perhaps their most-appealing trait. Based on the current momentum within the U.S. EPA to develop better models and contain regulatory burdens on industry, it is likely that air dispersion modeling will be a major player in future air regulatory initiatives.

  7. Air Force Research Laboratory, Edwards Air Force Base, CA

    DTIC Science & Technology

    2011-06-27

    Air Force Research Laboratory (AFMC) AFRL /RZS 1 Ara Road Edwards AFB CA 93524-7013 AFRL -RZ-ED-VG-2011-269 9...SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) Air Force Research Laboratory (AFMC) AFRL /RZS 11. SPONSOR...Form 298 (Rev. 8-98) Prescribed by ANSI Std. 239.18 Air Force Research Laboratory Ed d Ai F B CA Col Mike Platt war s r orce

  8. Nitrogen fluorescence in air for observing extensive air showers

    NASA Astrophysics Data System (ADS)

    Keilhauer, B.; Bohacova, M.; Fraga, M.; Matthews, J.; Sakaki, N.; Tameda, Y.; Tsunesada, Y.; Ulrich, A.

    2013-06-01

    Extensive air showers initiate the fluorescence emissions from nitrogen molecules in air. The UV-light is emitted isotropically and can be used for observing the longitudinal development of extensive air showers in the atmosphere over tenth of kilometers. This measurement technique is well-established since it is exploited for many decades by several cosmic ray experiments. However, a fundamental aspect of the air shower analyses is the description of the fluorescence emission in dependence on varying atmospheric conditions. Different fluorescence yields affect directly the energy scaling of air shower reconstruction. In order to explore the various details of the nitrogen fluorescence emission in air, a few experimental groups have been performing dedicated measurements over the last decade. Most of the measurements are now finished. These experimental groups have been discussing their techniques and results in a series of Air Fluorescence Workshops commenced in 2002. At the 8th Air Fluorescence Workshop 2011, it was suggested to develop a common way of describing the nitrogen fluorescence for application to air shower observations. Here, first analyses for a common treatment of the major dependences of the emission procedure are presented. Aspects like the contributions at different wavelengths, the dependence on pressure as it is decreasing with increasing altitude in the atmosphere, the temperature dependence, in particular that of the collisional cross sections between molecules involved, and the collisional de-excitation by water vapor are discussed.

  9. Air support facilities. [interface between air and surface transportation systems

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Airports are discussed in terms of the interface between the ground and air for transportation systems. The classification systems, design, facilities, administration, and operations of airports are described.

  10. Air-storage systems

    NASA Astrophysics Data System (ADS)

    Doherty, T. J.

    1981-10-01

    The air storage system, the critical component making compressed air energy storage technically economically feasible, is described in three of its forms. All have geological containments and reflect economics of scale requiring fairly large plant ratings and storage capacities. All three systems also are based on good precedent experience and there are a number of willing bidders in the engineering and construction field attesting to the readiness of the technology. The salient features of each storage system type are summarized. Hard rock caverns have the widest siting opportunity with a variety of geology, are well within construction capability in good quality rock with maximum control of system design through engineering, and have the highest cost of the storage system options study. They have the potential for longest time to startup and are difficult and expensive to expand for increased storage or plant rating. The salt-solutioned cavern has limited siting opportunities, is a very economical storage system, and storage increase is possible through cavern additions.

  11. Indoor air quality medicolegal issues.

    PubMed

    Ross, C S; Lockey, J E

    1994-08-01

    The regulatory and legal communities have begun only recently to address the medicolegal issues surrounding indoor air quality. No single governmental agency is responsible for indoor air quality issues. The focus of the federal government's indoor air quality programs is on the gathering and dissemination of information rather than on the regulation of indoor air pollution. State and local regulatory controls vary but may include antismoking ordinances, building codes, and contractor certification programs. Numerous lawsuits involving various parties and legal theories have been filed on the basis of illness allegedly related to indoor air quality. Further regulatory and legal review of indoor air problems will likely occur in the near future, particularly as a result of the characterization of environmental tobacco smoke as a class A carcinogen.

  12. Air ions and aerosol science

    SciTech Connect

    Tammet, H.

    1996-03-01

    Collaboration between Gas Discharge and Plasma Physics, Atmospheric Electricity, and Aerosol Science is a factor of success in the research of air ions. The concept of air ion as of any carrier of electrical current through the air is inherent to Atmospheric Electricity under which a considerable statistical information about the air ion mobility spectrum is collected. A new model of air ion size-mobility correlation has been developed proceeding from Aerosol Science and joining the methods of neighboring research fields. The predicted temperature variation of the mobility disagrees with the commonly used Langevin rule for the reduction of air ion mobilities to the standard conditions. Concurrent errors are too big to be neglected in applications. The critical diameter distinguishing cluster ions and charged aerosol particles has been estimated to be 1.4{endash}1.8 nm. {copyright} {ital 1996 American Institute of Physics.}

  13. Air handling units for hospitals.

    PubMed

    Amoroso, V; Gjestvang, R

    1989-10-01

    Air handling units should provide proper quality and conditioned air to various hospital areas. Unit capacity should be able to meet limited space functionality or load changes as well as any smoke control requirements. System components should be readily accessible and appropriate for spaces served. In summary, engineers should consider the following: Environmental design criteria for area being served Components desired Unit type required Economic issues affecting design. Using this approach, design engineers can design hospital air handling units methodically and logically.

  14. Air-Powered Projectile Launcher

    NASA Technical Reports Server (NTRS)

    Andrews, T.; Bjorklund, R. A.; Elliott, D. G.; Jones, L. K.

    1987-01-01

    Air-powered launcher fires plastic projectiles without using explosive propellants. Does not generate high temperatures. Launcher developed for combat training for U.S. Army. With reservoir pressurized, air launcher ready to fire. When pilot valve opened, sleeve (main valve) moves to rear. Projectile rapidly propelled through barrel, pushed by air from reservoir. Potential applications in seismic measurements, avalanche control, and testing impact resistance of windshields on vehicles.

  15. Disinfecting Filters For Recirculated Air

    NASA Technical Reports Server (NTRS)

    Pilichi, Carmine A.

    1992-01-01

    Simple treatment disinfects air filters by killing bacteria, algae, fungi, mycobacteria, viruses, spores, and any other micro-organisms filters might harbor. Concept applied to reusable stainless-steel wire mesh filters and disposable air filters. Treatment used on filters in air-circulation systems in spacecraft, airplanes, other vehicles, and buildings to help prevent spread of colds, sore throats, and more-serious illnesses.

  16. Natural Flow Air Cooled Photovoltaics

    NASA Astrophysics Data System (ADS)

    Tanagnostopoulos, Y.; Themelis, P.

    2010-01-01

    Our experimental study aims to investigate the improvement in the electrical performance of a photovoltaic installation on buildings through cooling of the photovoltaic panels with natural air flow. Our experimental study aims to investigate the improvement in the electrical performance of a photovoltaic installation on buildings through cooling of the photovoltaic panels with natural air flow. We performed experiments using a prototype based on three silicon photovoltaic modules placed in series to simulate a typical sloping building roof with photovoltaic installation. In this system the air flows through a channel on the rear side of PV panels. The potential for increasing the heat exchange from the photovoltaic panel to the circulating air by the addition of a thin metal sheet (TMS) in the middle of air channel or metal fins (FIN) along the air duct was examined. The operation of the device was studied with the air duct closed tightly to avoid air circulation (CLOSED) and the air duct open (REF), with the thin metal sheet (TMS) and with metal fins (FIN). In each case the experiments were performed under sunlight and the operating parameters of the experimental device determining the electrical and thermal performance of the system were observed and recorded during a whole day and for several days. We collected the data and form PV panels from the comparative diagrams of the experimental results regarding the temperature of solar cells, the electrical efficiency of the installation, the temperature of the back wall of the air duct and the temperature difference in the entrance and exit of the air duct. The comparative results from the measurements determine the improvement in electrical performance of the photovoltaic cells because of the reduction of their temperature, which is achieved by the naturally circulating air.

  17. Optical Measurements of Air Plasma

    DTIC Science & Technology

    2008-05-05

    generated in air by means of an electron beam is highly efficient. Fast electrons propagating through air result in production of electron- ion pairs...through the mechanism of impact ionization, which requires 33.7 eV per electron- ion pair. The air pressure, concentration of variable species, such as...and polyatomic species. Because our time scales are in the 1 ms to 10 ms range, there is a strong possibility of obtaining real-time absorption

  18. 14 CFR 298.52 - Air taxi operations by commuter air carriers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Air taxi operations by commuter air... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS EXEMPTIONS FOR AIR TAXI AND COMMUTER AIR CARRIER OPERATIONS Commuter Air Carrier Authorizations § 298.52 Air taxi operations by commuter air carriers. (a) A...

  19. 14 CFR 298.52 - Air taxi operations by commuter air carriers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Air taxi operations by commuter air... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS EXEMPTIONS FOR AIR TAXI AND COMMUTER AIR CARRIER OPERATIONS Commuter Air Carrier Authorizations § 298.52 Air taxi operations by commuter air carriers. (a) A...

  20. Air/fuel ratio controller

    SciTech Connect

    Schechter, M.M.; Simko, A.O.

    1980-12-23

    An internal combustion engine has a fuel injection pump and an air/fuel ratio controller. The controller has a lever that is connected to the pump lever. An aneroid moves the controller lever as a function of changes in intake manifold vacuum to maintain a constant air/fuel ratio to the mixture charge. A fuel enrichment linkage is provided that modifies the movement of the fuel flow control lever by the aneroid in response to changes in manifold gas temperature levels and exhaust gas recirculation to maintain the constant air/fuel ratio. A manual override is provided to obtain a richer air/fuel ratio for maximum acceleration.

  1. [Air quality and climate change].

    PubMed

    Loft, Steffen

    2009-10-26

    Air quality, health and climate change are closely connected. Ozone depends on temperature and the greenhouse gas methane from cattle and biomass. Pollen presence depends on temperature and CO2. The effect of climate change on particulate air pollution is complex, but the likely net effect is greater health risks. Reduction of greenhouse-gas emissions by reduced livestock production and use of combustion for energy production, transport and heating will also improve air quality. Energy savings in buildings and use of CO2 neutral fuels should not deteriorate indoor and outdoor air quality.

  2. Thin cylindrical sheets of air

    NASA Astrophysics Data System (ADS)

    Thoroddsen, Sigurdur; Beilharz, Daniel; Guyon, Axel; Li, Er Qiang; Thoraval, Marie-Jean

    2014-11-01

    Drops impacting at low velocities onto a pool surface can stretch out thin hemispheric sheets of air. These air sheets can remain intact until they reach submicron thicknesses, whereby they rupture to form myriad of microbubbles. By impacting a higher-viscosity drop onto a lower-viscosity pool, we have explored new geometries of such air films. In this way we are able to maintain stable air-layers which can wrap around the entire drop to form anti-bubbles, i.e. spherical air layers bounded by inner and outer liquid masses. Furthermore, for the most viscous drops they enter the pool trailing a viscous thread from the pinch-off from the nozzle. The air sheet can also wrap around these treads and remain stable over extended time to form a cylindrical air sheet. We study the parameter regime where these structures appear and their subsequent breakup. The stability of these air cylinders is inconsistent with inviscid stability theory, suggesting stabilization by lubrication forces within the submicron air layer.

  3. Indoor Air Quality in Schools

    EPA Pesticide Factsheets

    This web site will educate the public about indoor environmental issues specific to educational facilities and the importance of developing and sustaining comprehensive indoor air quality management programs.

  4. Aerodynamical sealing by air curtains

    NASA Astrophysics Data System (ADS)

    Frank, Daria; Linden, Paul

    2015-11-01

    Air curtains are artificial high-velocity plane turbulent jets which are installed in a doorway in order to reduce the heat and the mass exchange between two environments. The performance of an air curtain is assessed in terms of the sealing effectiveness E, the fraction of the exchange flow prevented by the air curtain compared to the open-door situation. The main controlling parameter for air curtain dynamics is the deflection modulus Dm representing the ratio of the momentum flux of the air curtain and the transverse forces acting on it due to the stack effect. In this talk, we examine the influence of two factors on the performance of an air curtain: the presence of an additional ventilation pathway in the room, such as a small top opening, and the effects of an opposing buoyancy force which for example arises if a downwards blowing air curtain is heated. Small-scale experiments were conducted to investigate the E (Dm) -curve of an air curtain in both situations. We present both experimental results and theoretical explanations for our observations. We also briefly illustrate how simplified models developed for air curtains can be used for more complex phenomena such as the effects of wind blowing around a model building on the ventilation rates through the openings.

  5. The particles in town air

    PubMed Central

    Ellison, J. McK.

    1965-01-01

    Particles constitute an important part of air pollution, and their behaviour when suspended in air is very different from that of gas molecules: in particular, the mechanisms by which they become deposited on surfaces are different, and consequently the methods normally used for removing particles from the air, either for sampling or for cleaning it, rely mainly on mechanisms that do not enter into the behaviour of gas molecules. These mechanisms are described, and the ways in which they affect the problems of air pollution and its measurement are discussed. ImagesFIG. 8 PMID:14315713

  6. Cold air systems: Sleeping giant

    SciTech Connect

    MacCracken, C.D. )

    1994-04-01

    This article describes how cold air systems help owners increase the profits from their buildings by reducing electric costs and improving indoor air quality through lower relative humidity levels. Cold air distribution involves energy savings, cost savings, space savings, greater comfort, cleaner air, thermal storage, tighter ducting, coil redesign, lower relative humidities, retrofitting, and improved indoor air quality (IAQ). It opens a door for architects, engineers, owners, builders, environmentalists, retrofitters, designers, occupants, and manufacturers. Three things have held up cold air's usage: multiple fan-powered boxes that ate up the energy savings of primary fans. Cold air room diffusers that provided inadequate comfort. Condensation from ducts, boxes, and diffusers. Such problems have been largely eliminated through research and development by utilities and manufacturers. New cold air diffusers no longer need fan powered boxes. It has also been found that condensation is not a concern so long as the ducts are located in air conditioned space, such as drop ceilings or central risers, where relative humidity falls quickly during morning startup.

  7. Air bearing vacuum seal assembly

    DOEpatents

    Booth, Rex

    1978-01-01

    An air bearing vacuum seal assembly capable of rotating at the speed of several thousand revolutions per minute using an air cushion to prevent the rotating and stationary parts from touching, and a two stage differential pumping arrangement to maintain the pressure gradient between the air cushion and the vacuum so that the leak rate into the vacuum is, for example, less than 1 .times. 10.sup.-4 Pa m.sup.3 /s. The air bearing vacuum seal has particular application for mounting rotating targets to an evacuated accelerator beam tube for bombardment of the targets with high-power charged particle beams in vacuum.

  8. Auditory Risk of Air Rifles

    PubMed Central

    Lankford, James E.; Meinke, Deanna K.; Flamme, Gregory A.; Finan, Donald S.; Stewart, Michael; Tasko, Stephen; Murphy, William J.

    2016-01-01

    Objective To characterize the impulse noise exposure and auditory risk for air rifle users for both youth and adults. Design Acoustic characteristics were examined and the auditory risk estimates were evaluated using contemporary damage-risk criteria for unprotected adult listeners and the 120-dB peak limit and LAeq75 exposure limit suggested by the World Health Organization (1999) for children. Study sample Impulses were generated by 9 pellet air rifles and 1 BB air rifle. Results None of the air rifles generated peak levels that exceeded the 140 dB peak limit for adults and 8 (80%) exceeded the 120 dB peak SPL limit for youth. In general, for both adults and youth there is minimal auditory risk when shooting less than 100 unprotected shots with pellet air rifles. Air rifles with suppressors were less hazardous than those without suppressors and the pellet air rifles with higher velocities were generally more hazardous than those with lower velocities. Conclusion To minimize auditory risk, youth should utilize air rifles with an integrated suppressor and lower velocity ratings. Air rifle shooters are advised to wear hearing protection whenever engaging in shooting activities in order to gain self-efficacy and model appropriate hearing health behaviors necessary for recreational firearm use. PMID:26840923

  9. Sights from the air

    NASA Astrophysics Data System (ADS)

    Tartara, P.

    2009-04-01

    The first aerial shots were taken by aerostat balloon during the second half of the nineteen century for military purpose and subsequently utilized for civilian, archaeological and town planning uses (Roman Forum 1900, Pompei 1910, Venezia 1913, etc.). Sights from the air have given the most objective representation of the landscape and traces progressively left by human activities. After the First World War the use of airplanes for photogrammetric shots suitable to create cartography (territorial map making) has permitted to realize a good basic documentation; successively it has been increased by aerial reconnaissance during the Second World War. Aerial shots by RAF, USAF and Luftwaffe brought to the establishment of rich aerial photograph Archives, particularly in Europe, which have had a very low utilization for the historical restoration of landscape. From the fifties, aerial documentation becomes systematic for different scale analysis and territorial planning. The use of satellite imagery and multispectral bands integrates the historical and recent aerial photographs; the former is particularly helpful for cartography updating, for large scale environmental analysis, for study and research of territories with not available air photographs or lacking in aerial shots. The amount and density of archaeological buried evidences, unknown at the most, is very substantial in Italy and in the whole Mediterranean area; here air-photo interpretation is being applied at advanced levels, but not systematically, since several decades. Some archaeological research teams, working for the knowledge of territorial cultural heritage, utilize historical and recent aerial photographs intensively (aerial photographs previous the II WW, just before the intensive and extensive use of mechanical means to till the land, preserve a large amount of traces or cropmarks of buried evidences; recent shots taken on different conditions of climate and crops, allow to see and read important

  10. Air Quality | Air Quality Planning & Standards | US EPA

    EPA Pesticide Factsheets

    2016-06-08

    Air pollution comes from many different sources: stationary sources such as factories, power plants, and smelters and smaller sources such as dry cleaners and degreasing operations; mobile sources such as cars, buses, planes, trucks, and trains; and naturally occurring sources such as windblown dust, and volcanic eruptions, all contribute to air pollution.

  11. Air To Air Helicopter Fire Control Equations and Software Generation.

    DTIC Science & Technology

    1979-11-01

    FORM I. REPORT NUMBER 12. GOVT ACCE NO S.SCIP1INTIS CATALOG NUMBER Air To Air Helicop~ter Fire Control 1I t 31Au Equations and Software Generation oN.m...differentiator in order to model the way that they are added in the track loop before the capacitor coupled tachometer feedback. AIRSIM Data Representative output

  12. HATCH CONNECTING TEMPERED AIR CHAMBER AND HOT AIR CHAMBER OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HATCH CONNECTING TEMPERED AIR CHAMBER AND HOT AIR CHAMBER OF PLENUM WITH ATTACHED DRAFT REGULATOR. - Hot Springs National Park, Bathhouse Row, Superior Bathhouse: Mechanical & Piping Systems, State Highway 7, 1 mile north of U.S. Highway 70, Hot Springs, Garland County, AR

  13. Air Pollution Emissions | Air Quality Planning & Standards | US ...

    EPA Pesticide Factsheets

    2016-06-08

    Air pollution comes from many different sources: stationary sources such as factories, power plants, and smelters and smaller sources such as dry cleaners and degreasing operations; mobile sources such as cars, buses, planes, trucks, and trains; and naturally occurring sources such as windblown dust, and volcanic eruptions, all contribute to air pollution.

  14. Colorado Air Quality Control Regulations and Ambient Air Quality Standards.

    ERIC Educational Resources Information Center

    Colorado State Dept. of Health, Denver. Div. of Air Pollution Control.

    Regulations and standards relative to air quality control in Colorado are defined in this publication. Presented first are definitions of terms, a statement of intent, and general provisions applicable to all emission control regulations adopted by the Colorado Air Pollution Control Commission. Following this, three regulations are enumerated: (1)…

  15. Air-storage systems

    SciTech Connect

    Doherty, T.J.

    1981-10-01

    The air storage system, the critical component making CAES technically and economically feasible, is described in three of its forms. All have geological containments and reflect economics of scale requiring fairly large plant ratings and storage capacities. All three systems also are based on good precedent experience and there are a number of willing bidders in the engineering and construction field attesting to the readiness of the technology. The salient features of each storage system type are summarized. Hard rock caverns have the widest siting opportunity in a variety of geology, are well within construction capability in good quality rock with maximum control of system design through engineering, have the highest cost of the storage system options study and the potential for longest time to startup, are difficult and expensive to expand for increased storage or plant rating. The salt-solutioned cavern has limited siting opportunities, is a very economical storage system, and storage increase is possible through cavern additions.

  16. Air pollution source identification

    NASA Technical Reports Server (NTRS)

    Fordyce, J. S.

    1975-01-01

    Techniques for air pollution source identification are reviewed, and some results obtained with them are evaluated. Described techniques include remote sensing from satellites and aircraft, on-site monitoring, and the use of injected tracers and pollutants themselves as tracers. The use of a large number of trace elements in ambient airborne particulate matter as a practical means of identifying sources is discussed in detail. Sampling and analysis techniques are described, and it is shown that elemental constituents can be related to specific source types such as those found in the earth's crust and those associated with specific industries. Source identification sytems are noted which utilize charged particle X-ray fluorescence analysis of original field data.

  17. Indoor air pollution.

    PubMed

    Gold, D R

    1992-06-01

    This article summarizes the health effects of indoor air pollutants and the modalities available to control them. The pollutants discussed include active and passive exposure to tobacco smoke; combustion products of carbon monoxide; nitrogen dioxide; products of biofuels, including wood and coal; biologic agents leading to immune responses, such as house dust mites, cockroaches, fungi, animal dander, and urine; biologic agents associated with infection such as Legionella and tuberculosis; formaldehyde; and volatile organic compounds. An approach to assessing building-related illness and "tight building" syndrome is presented. Finally, the article reviews recent data on hospital-related asthma and exposures to potential respiratory hazards such as antineoplastic agents, anesthetic gases, and ethylene oxide.

  18. Air Quality Monitor

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Stak-Tracker CEM (Continuous Emission Monitor) Gas Analyzer is an air quality monitor capable of separating the various gases in a bulk exhaust stream and determining the amounts of individual gases present within the stream. The monitor is produced by GE Reuter- Stokes, a subsidiary of GE Corporate Research & Development Center. The Stak-Tracker uses a Langley Research Center software package which measures the concentration of a target gas by determining the degree to which molecules of that gas absorb an infrared beam. The system is environmental-friendly, fast and has relatively low installation and maintenance costs. It is applicable to gas turbines and various industries including glass, paper and cement.

  19. Reactive Air Aluminization

    SciTech Connect

    Choi, Jung-Pyung; Chou, Y. S.; Stevenson, Jeffry W.

    2011-10-28

    Ferritic stainless steels and other alloys are of great interest to SOFC developers for applications such as interconnects, cell frames, and balance of plant components. While these alloys offer significant advantages (e.g., low material and manufacturing cost, high thermal conductivity, and high temperature oxidation resistance), there are challenges which can hinder their utilization in SOFC systems; these challenges include Cr volatility and reactivity with glass seals. To overcome these challenges, protective coatings and surface treatments for the alloys are under development. In particular, aluminization of alloy surfaces offers the potential for mitigating both evaporation of Cr from the alloy surface and reaction of alloy constituents with glass seals. Commercial aluminization processes are available to SOFC developers, but they tend to be costly due to their use of exotic raw materials and/or processing conditions. As an alternative, PNNL has developed Reactive Air Aluminization (RAA), which offers a low-cost, simpler alternative to conventional aluminization methods.

  20. Indoor air pollution

    SciTech Connect

    Gold, D.R. )

    1992-06-01

    This article summarizes the health effects of indoor air pollutants and the modalities available to control them. The pollutants discussed include active and passive exposure to tobacco smoke; combustion products of carbon monoxide; nitrogen dioxide; products of biofuels, including wood and coal; biologic agents leading to immune responses, such as house dust mites, cockroaches, fungi, animal dander, and urine; biologic agents associated with infection such as Legionella and tuberculosis; formaldehyde; and volatile organic compounds. An approach to assessing building-related illness and tight building' syndrome is presented. Finally, the article reviews recent data on hospital-related asthma and exposures to potential respiratory hazards such as antineoplastic agents, anesthetic gases, and ethylene oxide.88 references.

  1. Clearing the air

    SciTech Connect

    Naquin, D.

    1998-05-01

    Like thunderclouds, predictions of doom for the environment and for business interests hover over the international climate treaty completed in Kyoto, Japan, last December. In the agreement, dubbed the Kyoto Protocol, participating countries agreed to reduce greenhouse gas (GHG) emissions below 1990 levels in an effort to slow down the phenomenon known as global warming. However, real-life effects of the United Nations-sponsored summit remain up in the air. Proposed regulation of greenhouse gas emissions would have profound effects on worldwide economies -- particularly the waste industry. But the Kyoto Protocol does not appear to satisfy any one group`s interests. This article examines all sides of this contentious and ongoing debate.

  2. Future Air Force systems.

    PubMed

    Tremaine, S A

    1986-10-01

    Planning for the future is under way in earnest at the Aeronautical Systems Division (ASD) at Wright-Patterson Air Force Base. It has been statistically established that it takes from 14-16 years from the generation of a new system idea to enter into engineering development. With this unpleasing, but realistic, schedule in mind, ASD has, during the last 3 years, been initiating long-term planning projects that are pre-starts for new system ideas. They are generated from throughout the Air Force and are locally managed and funded. Through this process, which spans from 12-14 months, specific and revolutionary new ideas for the systems of the future are generated. This article addresses more than a dozen specific new ideas in work at ASD today. These ideas range from a need to replace the C-130 type aircraft after the year 2000 to planning a follow-on to the B-18 well into the 21st century. Among other specific projects are investigation into an immortal fighter intended to be free of reliability and maintenance demands for an especially long period of operation, a new training system and advanced trainer to replace the T-38, a transatmospheric vehicle that could operate in the 100,000-500,000 foot flight region (30,480-152,400 m), and a new means of defending against hostile cruise missile launchers and cruise missiles. Other ideas are also addressed. The article concludes with emphasis on systems that can operate hypersonically in and out of the known atmosphere and greater use of airbreathing propulsion systems operating between Mach 3 and Mach 6.

  3. Advanced Metallic Air Vehicle Structure Program

    DTIC Science & Technology

    1976-08-01

    Patterson Air Force Base , Ohio 45433. AIR FORCE FLIGHT DYNAMICS LABORATORY AIR FORCE WRIGHT AERONAUTICAL LABORATORIES AIR FORCE SYSTEMS COMMAND Best...Available Copy WRIGHT-PATTERSON AIR FORCE BASE , OHIO 45433 THIS DOCUMENT CONTAINED C) BLANK PAGES THAT HAVE 0 3 BEEN DELETED 9 NOTICES When Government...December 1975. Other requests for this document must be referred to Air Force Flight Dynamics Laboratory (FB-A), Wright-Patterson Air Force Base , Ohio

  4. 78 FR 12267 - Revision of Air Quality Implementation Plan; California; Placer County Air Pollution Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... Pollution Control District and Feather River Air Quality Management District; Stationary Source Permits... County Air Pollution Control District (PCAPCD) and Feather River Air Quality Management District...

  5. Reduced bleed air extraction for DC-10 cabin air conditioning

    NASA Technical Reports Server (NTRS)

    Newman, W. H.; Viele, M. R.; Hrach, F. J.

    1980-01-01

    It is noted that a significant fuel savings can be achieved by reducing bleed air used for cabin air conditioning. Air in the cabin can be recirculated to maintain comfortable ventilation rates but the quality of the air tends to decrease due to entrainment of smoke and odors. Attention is given to a development system designed and fabricated under the NASA Engine Component Improvement Program to define the recirculation limit for the DC-10. It is shown that with the system, a wide range of bleed air reductions and recirculation rates is possible. A goal of 0.8% fuel savings has been achieved which results from a 50% reduction in bleed extraction from the engine.

  6. Air Leakage Rates in Typical Air Barrier Assemblies

    SciTech Connect

    Hun, Diana E.; Atchley, Jerald Allen; Childs, Phillip W.

    2016-11-01

    Estimates for 2010 indicate that infiltration in residential buildings was responsible for 2.85 quads of energy (DOE 2014), which is about 3% of the total energy consumed in the US. One of the mechanisms being implemented to reduce this energy penalty is the use of air barriers as part of the building envelope. These technologies decrease airflow through major leakage sites such as oriented strand board (OSB) joints, and gaps around penetrations (e.g., windows, doors, pipes, electrical outlets) as indicated by Hun et al. (2014). However, most air barrier materials do not properly address leakage spots such as wall-to-roof joints and wall-to-foundation joints because these are difficult to seal, and because air barrier manufacturers usually do not provide adequate instructions for these locations. The present study focuses on characterizing typical air leakage sites in wall assemblies with air barrier materials.

  7. An air quality sensing system for cool air storage

    NASA Astrophysics Data System (ADS)

    Ngoy, T. J.; Joubert, T.-H.

    2016-02-01

    Cooling and ventilation systems play an important role in human occupied spaces. However, cooling using reversible air conditioners systems pollutes the environment and consumes a significant amount of energy. With global warming that experiences our environment, the large consumption of electrical energy and the operating instructions for reversible air conditioners, there is a need to find alternatives to those cooling systems. Hence this research project aims to investigate an air storage system, a microsystem reversible ventilation system using natural atmospheric air (renewable energy) for cooling at low consumption of energy. For the variation of the temperature range of comfort due to thermal heat produces by occupants, equipment and environment, an optimal transient automatic regulation of air flow as to be design in order to maintain the temperature of comfort in occupied spaces during peak hours.

  8. Children, Pediatricians, and Polluted Air.

    ERIC Educational Resources Information Center

    Kane, Dorothy Noyes

    Explored are children's vulnerability and the pediatrician's role in relation to the problems posed by air pollution. Research is noted to have included a search of biomedical literature over the past 10 years; attendance at medical meetings; conferences with air pollution researchers, environmental protection administrators, and specialists in…

  9. Mind Your Indoor Air Quality

    ERIC Educational Resources Information Center

    Mak, Lily

    2012-01-01

    When it comes to excelling in the classroom, it turns out the air students are breathing is just as important as the lessons they are learning. Studies show poor indoor air quality (IAQ) can lessen the comfort of students as well as staff--affecting concentration, attendance and student performance. It can even lead to lower IQs. What's more, poor…

  10. A Breath of Fresh Air

    ERIC Educational Resources Information Center

    Belew, Rachel

    2011-01-01

    One of the most important aspects of a healthy school--and one that, unfortunately, often falls by the wayside--is indoor air quality. The U.S. Government Accountability Office estimates that more than 15,000 schools nationwide report suffering from poor indoor air quality. According to the U.S. Environmental Protection Agency, schools with poor…

  11. The Clean Air Mercury Rule

    SciTech Connect

    Michael Rossler

    2005-07-01

    Coming into force on July 15, 2005, the US Clean Air Mercury Rule will use a market-based cap-and-trade approach under Section 111 of the Clean Air Act to reduce mercury emissions from the electric power sector. This article provides a comprehensive summary of the new rule. 14 refs., 2 tabs.

  12. Air Pollution and Human Health

    ERIC Educational Resources Information Center

    Lave, Lester B.; Seskin, Eugene P.

    1970-01-01

    Reviews studies statistically relating air pollution to mortality and morbidity rates for respiratory, and cardiovascular diseases, cancer and infant mortality. Some data recalculated. Estimates 50 percent air pollution reduction will save 4.5 percent (2080 million dollars per year) of all economic loss (hospitalization, income loss) associated…

  13. Protective supplied breathing air garment

    DOEpatents

    Childers, E.L.; Hortenau, E.F. von.

    1984-07-10

    A breathing air garment is disclosed for isolating a wearer from hostile environments containing toxins or irritants includes a suit and a separate head protective enclosure or hood engaging a suit collar in sealing attachment. The hood and suit collar are cylindrically shaped and dimensioned to enable the wearer to withdraw his hands from the suit sleeves to perform manual tasks within the hood interior. Breathing air is supplied from an external air line with an air delivery hose attached to the hood interior. The hose feeds air into an annular halo-like fiber-filled plenum having spaced discharge orifices attached to the hood top wall. A plurality of air exhaust/check valves located at the suit extremities cooperate with the hood air delivery system to provide a cooling flow of circulating air from the hood throughout the suit interior. A suit entry seal provided on the suit rear torso panel permits access into the suit and is sealed with an adhesive sealing flap. 17 figs.

  14. Protective supplied breathing air garment

    DOEpatents

    Childers, Edward L.; von Hortenau, Erik F.

    1984-07-10

    A breathing air garment for isolating a wearer from hostile environments containing toxins or irritants includes a suit and a separate head protective enclosure or hood engaging a suit collar in sealing attachment. The hood and suit collar are cylindrically shaped and dimensioned to enable the wearer to withdraw his hands from the suit sleeves to perform manual tasks within the hood interior. Breathing air is supplied from an external air line with an air delivery hose attached to the hood interior. The hose feeds air into an annular halo-like fiber-filled plenum having spaced discharge orifices attached to the hood top wall. A plurality of air exhaust/check valves located at the suit extremities cooperate with the hood air delivery system to provide a cooling flow of circulating air from the hood throughout the suit interior. A suit entry seal provided on the suit rear torso panel permits access into the suit and is sealed with an adhesive sealing flap.

  15. Title III hazardous air pollutants

    SciTech Connect

    Todd, R.

    1995-12-31

    The author presents an overview of the key provisions of Title III of the Clean Air Act Amendments of 1990. The key provisions include the following: 112(b) -- 189 Hazardous Air Pollutants (HAP); 112(a) -- Major Source: 10 TPY/25 TPY; 112(d) -- Application of MACT; 112(g) -- Modifications; 112(I) -- State Program; 112(j) -- The Hammer; and 112(r) -- Accidental Release Provisions.

  16. In Search of Air Pollution

    ERIC Educational Resources Information Center

    Beckendorf, Kirk

    2006-01-01

    Air pollution is no longer just a local issue; it is a global problem. The atmosphere is a very dynamic system. Pollution not only changes in chemical composition after it is emitted, but also is transported on local and global air systems hundreds and even thousands of miles away. Some of the pollutants that are major health concerns are not even…

  17. The Federal Air Pollution Program.

    ERIC Educational Resources Information Center

    National Air Pollution Control Administration (DHEW), Washington, DC.

    Described is the Federal air pollution program as it was in 1967. The booklet is divided into these major topics: History of the Federal Program; Research; Assistance to State and Local Governments; Abatement and Prevention of Air Pollution; Control of Motor Vehicle Pollution; Information and Education; and Conclusion. Federal legislation has…

  18. ENGINEERING BULLETIN: AIR PATHWAY ANALYSIS

    EPA Science Inventory

    This bulletin presents information on estimating toxic air emissions from Superfund sites. The focus is on the collection of air emmissions data during the site inspection and remedial investigation/feasibility study and the use of these data for the selection or implementation o...

  19. [Indoor air quality in schools].

    PubMed

    Cartieaux, E; Rzepka, M-A; Cuny, D

    2011-07-01

    Indoor air quality in schools has received particular attention over the past several years. Children are considered as one of the most sensitive groups to atmospheric pollution because their bodies are actively growing and they breathe higher volumes of air relative to their body weights than adults do. They also spend more time in school or group structures (preschools, day nurseries) than in any indoor environments other than the home. The analysis of children's exposure to air pollution at school requires the identification of the main pollutant sources present in these educational institutions. Both a strong contribution of outdoor pollution and a very specific pollution bound to school activities such as the use of paints, markers, glues, and manufactured ink eraser pens, exist. The ventilation in school buildings also plays an important role in air quality. A higher air exchange may improve thermal comfort and air quality. The cause of indoor air pollution is a combinatory effect of physical, chemical, and biological factors, and the adequacy of ventilation in the environment. Several pollutants have been reported to exist in classrooms such as bacteria, molds, volatile organic compounds, persistent organic pollutants and microparticles. There is a correlation between the concentrations of the pollutants and onset of health problems in schoolchildren. We observe predominantly respiratory symptoms as well as a prevalence of respiratory diseases such as asthma and allergies. This study shows that poor indoor air quality affects children's health.

  20. Energy conservation and air transportation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Air transportation demand and passenger energy demand are discussed, in relation to energy conservation. Alternatives to air travel are reviewed, along with airline advertising and ticket pricing. Cargo energy demand and airline systems efficiency are also examined, as well as fuel conservation techniques. Maximum efficiency of passenger aircraft, from B-747 to V/STOL to British Concorde, is compared.

  1. Reengineering the Air Travel Process

    DTIC Science & Technology

    1999-04-01

    Thesis 3. DATES COVERED (FROM - TO) xx-xx-1999 to xx-xx-1999 4. TITLE AND SUBTITLE Reengineering the Air Travel Process Unclassified 5a. CONTRACT...RELEASE , 13. SUPPLEMENTARY NOTES 14. ABSTRACT Every year, Department of Defense (DOD) travelers make thousands of trips that include air transportation

  2. Air Pollution Control, Part I.

    ERIC Educational Resources Information Center

    Strauss, Werner, Ed.

    Authoritative reviews in seven areas of current importance in air pollution control are supplied in this volume, the first of a two-part set. Titles contained in this book are: "Dispersion of Pollutants Emitted into the Atmosphere,""The Formation and Control of Oxides of Nitrogen in Air Pollution,""The Control of Sulfur Emissions from Combustion…

  3. New Federal Air Quality Standards.

    ERIC Educational Resources Information Center

    Stopinski, O. W.

    The report discusses the current procedures for establishing air quality standards, the bases for standards, and, finally, proposed and final National Primary and Secondary Ambient Air Quality Standards for sulfur dioxide, particulate matter, carbon monoxide, nonmethane hydrocarbons, photochemical oxidants, and nitrogen dioxide. (Author/RH)

  4. Screening in humid air plasmas

    NASA Astrophysics Data System (ADS)

    Filippov, Anatoly; Derbenev, Ivan; Dyatko, Nikolay; Kurkin, Sergey

    2016-09-01

    Low temperature air plasmas containing H2O molecules are of high importance for atmospheric phenomena, climate control, biomedical applications, surface processing, and purification of air and water. Humid air plasma created by an external ionization source is a good model of the troposphere where ions are produced by the galactic cosmic rays and decay products of air and soil radioactive elements such as Rn222. The present paper is devoted to study the ionic composition and the screening in an ionized humid air at atmospheric pressure and room temperature. The ionization rate is varied in the range of 101 -1018 cm-3s-1. The humid air with 0 - 1 . 5 % water admixture that corresponds to the relative humidity of 0 - 67 % at the air temperature equal to 20°C is considered. The ionic composition is determined on the analysis of more than a hundred processes. The system of 41 non-steady state particle number balance equations is solved using the 4th order Runge-Kutta method. The screening of dust particle charge in the ionized humid air are studied within the diffusion-drift approach. The screening constants are well approximated by the inverse Debye length and characteristic lengths of recombination and attachment processes. This work was supported by the Russian Science Foundation, Project No. 16-12-10424.

  5. Team 2: AIRS Only Retrieval

    NASA Technical Reports Server (NTRS)

    Lee, Sung-Yung; Manning, Evan; Blaisdell, John; Susskind, Joel; Barnet, Chris; Goldberg, Mitch; Cho, Chuck; Staelin, Dave; Blackwelll, Bill

    2005-01-01

    This slide presentation makes the case for the retrieval of data from the Atmospheric Infrared Sounder (AIRS) Advanced Microwave Sounding Unit (AMSU). AIRS only retrieval is not only a risk reduction for failure of AMSU, but also important because NWP centers are reluctant to assimilate AMSU twice.

  6. Airborne rotary air separator study

    NASA Technical Reports Server (NTRS)

    Acharya, A.; Gottzmann, C. F.; Nowobilski, J. J.

    1990-01-01

    Several air breathing propulsion concepts for future earth-to-orbit transport vehicles utilize air collection and enrichment, and subsequent storage of liquid oxygen for later use in the vehicle emission. Work performed during the 1960's established the feasibility of substantially reducing weight and volume of a distillation type air separator system by operating the distillation elements in high 'g' fields obtained by rotating the separator assembly. This contract studied the capability test and hydraulic behavior of a novel structured or ordered distillation packing in a rotating device using air and water. Pressure drop and flood points were measured for different air and water flow rates in gravitational fields of up to 700 g. Behavior of the packing follows the correlations previously derived from tests at normal gravity. The novel ordered packing can take the place of trays in a rotating air separation column with the promise of substantial reduction in pressure drop, volume, and system weight. The results obtained in the program are used to predict design and performance of rotary separators for air collection and enrichment systems of interest for past and present concepts of air breathing propulsion (single or two-stage to orbit) systems.

  7. Breathing Easy over Air Quality.

    ERIC Educational Resources Information Center

    Greim, Clifton; Turner, William

    1991-01-01

    School systems should test the air in every school building for the presence and level of contaminants such as radon and asbestos and whether the ventilation system is circulating the proper amount of air. Periodic maintenance is required for all mechanical systems. (MLF)

  8. Building Air Quality. Action Plan.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC. Indoor Air Div.

    Building managers and owners often confront competing demands to reduce operating costs and increase revenues that can siphon funds and resources from other building management concerns such as indoor air quality (IAQ). This resource booklet, designed for use with the "Building Air Quality Guide," provides building owners and managers with an…

  9. Air pollution and allergic disease.

    PubMed

    Kim, Haejin; Bernstein, Jonathan A

    2009-03-01

    Over the past several decades, there has been increased awareness of the health effects of air pollution and much debate regarding the role of global warming. The prevalence of asthma and allergic disease has risen in industrialized countries, and most epidemiologic studies focus on possible causalities between air pollution and these conditions. This review examines salient articles and summarizes findings important to the interaction between allergies and air pollution, specifically volatile organic compounds, global warming, particulate pollutants, atopic risk, indoor air pollution, and prenatal exposure. Further work is necessary to determine whether patients predisposed to developing allergic disease may be more susceptible to the health effects of air pollutants due to the direct interaction between IgE-mediated disease and air pollutants. Until we have more definitive answers, patient education about the importance of good indoor air quality in the home and workplace is essential. Health care providers and the general community should also support public policy designed to improve outdoor air quality by developing programs that provide incentives for industry to comply with controlling pollution emissions.

  10. Advanced Air Bag Technology Assessment

    NASA Technical Reports Server (NTRS)

    Phen, R. L.; Dowdy, M. W.; Ebbeler, D. H.; Kim. E.-H.; Moore, N. R.; VanZandt, T. R.

    1998-01-01

    As a result of the concern for the growing number of air-bag-induced injuries and fatalities, the administrators of the National Highway Traffic Safety Administration (NHTSA) and the National Aeronautics and Space Administration (NASA) agreed to a cooperative effort that "leverages NHTSA's expertise in motor vehicle safety restraint systems and biomechanics with NASAs position as one of the leaders in advanced technology development... to enable the state of air bag safety technology to advance at a faster pace..." They signed a NASA/NHTSA memorandum of understanding for NASA to "evaluate air bag to assess advanced air bag performance, establish the technological potential for improved technology (smart) air bag systems, and identify key expertise and technology within the agency (i.e., NASA) that can potentially contribute significantly to the improved effectiveness of air bags." NASA is committed to contributing to NHTSAs effort to: (1) understand and define critical parameters affecting air bag performance; (2) systematically assess air bag technology state of the art and its future potential; and (3) identify new concepts for air bag systems. The Jet Propulsion Laboratory (JPL) was selected by NASA to respond to the memorandum of understanding by conducting an advanced air bag technology assessment. JPL analyzed the nature of the need for occupant restraint, how air bags operate alone and with safety belts to provide restraint, and the potential hazards introduced by the technology. This analysis yielded a set of critical parameters for restraint systems. The researchers examined data on the performance of current air bag technology, and searched for and assessed how new technologies could reduce the hazards introduced by air bags while providing the restraint protection that is their primary purpose. The critical parameters which were derived are: (1) the crash severity; (2) the use of seat belts; (3) the physical characteristics of the occupants; (4) the

  11. Air pollution: Impact and prevention

    PubMed Central

    SIERRA-VARGAS, MARTHA PATRICIA; TERAN, LUIS M

    2012-01-01

    ABSTRACT Air pollution is becoming a major health problem that affects millions of people worldwide. In support of this observation, the World Health Organization estimates that every year, 2.4 million people die because of the effects of air pollution on health. Mitigation strategies such as changes in diesel engine technology could result in fewer premature mortalities, as suggested by the US Environmental Protection Agency. This review: (i) discusses the impact of air pollution on respiratory disease; (ii) provides evidence that reducing air pollution may have a positive impact on the prevention of disease; and (iii) demonstrates the impact concerted polices may have on population health when governments take actions to reduce air pollution. PMID:22726103

  12. Picosecond laser filamentation in air

    NASA Astrophysics Data System (ADS)

    Schmitt-Sody, Andreas; Kurz, Heiko G.; Bergé, Luc; Skupin, Stefan; Polynkin, Pavel

    2016-09-01

    The propagation of intense picosecond laser pulses in air in the presence of strong nonlinear self-action effects and air ionization is investigated experimentally and numerically. The model used for numerical analysis is based on the nonlinear propagator for the optical field coupled to the rate equations for the production of various ionic species and plasma temperature. Our results show that the phenomenon of plasma-driven intensity clamping, which has been paramount in femtosecond laser filamentation, holds for picosecond pulses. Furthermore, the temporal pulse distortions in the picosecond regime are limited and the pulse fluence is also clamped. In focused propagation geometry, a unique feature of picosecond filamentation is the production of a broad, fully ionized air channel, continuous both longitudinally and transversely, which may be instrumental for many applications including laser-guided electrical breakdown of air, channeling microwave beams and air lasing.

  13. Outdoor air pollution and asthma

    PubMed Central

    Guarnieri, Michael; Balmes, John R.

    2015-01-01

    Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma. PMID:24792855

  14. Atmospheric Chemistry and Air Pollution

    DOE PAGES

    Gaffney, Jeffrey S.; Marley, Nancy A.

    2003-01-01

    Atmospheric chemistry is an important discipline for understanding air pollution and its impacts. This mini-review gives a brief history of air pollution and presents an overview of some of the basic photochemistry involved in the production of ozone and other oxidants in the atmosphere. Urban air quality issues are reviewed with a specific focus on ozone and other oxidants, primary and secondary aerosols, alternative fuels, and the potential for chlorine releases to amplify oxidant chemistry in industrial areas. Regional air pollution issues such as acid rain, long-range transport of aerosols and visibility loss, and the connections of aerosols to ozonemore » and peroxyacetyl nitrate chemistry are examined. Finally, the potential impacts of air pollutants on the global-scale radiative balances of gases and aerosols are discussed briefly.« less

  15. Atmospheric chemistry and air pollution.

    PubMed

    Gaffney, Jeffrey S; Marley, Nancy A

    2003-04-07

    Atmospheric chemistry is an important discipline for understanding air pollution and its impacts. This mini-review gives a brief history of air pollution and presents an overview of some of the basic photochemistry involved in the production of ozone and other oxidants in the atmosphere. Urban air quality issues are reviewed with a specific focus on ozone and other oxidants, primary and secondary aerosols, alternative fuels, and the potential for chlorine releases to amplify oxidant chemistry in industrial areas. Regional air pollution issues such as acid rain, long-range transport of aerosols and visibility loss, and the connections of aerosols to ozone and peroxyacetyl nitrate chemistry are examined. Finally, the potential impacts of air pollutants on the global-scale radiative balances of gases and aerosols are discussed briefly.

  16. Air pollution: impact and prevention.

    PubMed

    Sierra-Vargas, Martha Patricia; Teran, Luis M

    2012-10-01

    Air pollution is becoming a major health problem that affects millions of people worldwide. In support of this observation, the World Health Organization estimates that every year, 2.4 million people die because of the effects of air pollution on health. Mitigation strategies such as changes in diesel engine technology could result in fewer premature mortalities, as suggested by the US Environmental Protection Agency. This review: (i) discusses the impact of air pollution on respiratory disease; (ii) provides evidence that reducing air pollution may have a positive impact on the prevention of disease; and (iii) demonstrates the impact concerted polices may have on population health when governments take actions to reduce air pollution.

  17. Lithium-Air Cell Development

    NASA Technical Reports Server (NTRS)

    Reid, Concha M.; Dobley, Arthur; Seymour, Frasier W.

    2014-01-01

    Lithium-air (Li-air) primary batteries have a theoretical specific capacity of 11,400 Wh/kg, the highest of any common metal-air system. NASA is developing Li-air technology for a Mobile Oxygen Concentrator for Spacecraft Emergencies, an application which requires an extremely lightweight primary battery that can discharge over 24 hours continuously. Several vendors were funded through the NASA SBIR program to develop Li-air technology to fulfill the requirements of this application. New catalysts and carbon cathode structures were developed to enhance the oxygen reduction reaction and increase surface area to improve cell performance. Techniques to stabilize the lithium metal anode surface were explored. Experimental results for prototype laboratory cells are given. Projections are made for the performance of hypothetical cells constructed from the materials that were developed.

  18. Estrogen turns down "the AIRE".

    PubMed

    Bakhru, Pearl; Su, Maureen A

    2016-04-01

    Genetic alterations are known drivers of autoimmune disease; however, there is a much higher incidence of autoimmunity in women, implicating sex-specific factors in disease development. The autoimmune regulator (AIRE) gene contributes to the maintenance of central tolerance, and complete loss of AIRE function results in the development of autoimmune polyendocrinopathy syndrome type 1. In this issue of the JCI, Dragin and colleagues demonstrate that AIRE expression is downregulated in females as the result of estrogen-mediated alterations at the AIRE promoter. The association between estrogen and reduction of AIRE may at least partially account for the elevated incidence of autoimmune disease in women and has potential implications for sex hormone therapy.

  19. 14 CFR Section 04 - Air Carrier Groupings

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Air Carrier Groupings Section 04 Section 04... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 04 Air Carrier Groupings (a) All large certificated air carriers are placed into three basic air carrier groupings...

  20. 14 CFR Section 04 - Air Carrier Groupings

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Air Carrier Groupings Section 04 Section 04... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 04 Air Carrier Groupings (a) All large certificated air carriers are placed into three basic air carrier groupings...

  1. Air Pollution in the World's Megacities.

    ERIC Educational Resources Information Center

    Richman, Barbara T., Ed.

    1994-01-01

    Reports findings of the Global Environment Monitoring System study concerning air pollution in the world's megacities. Discusses sources of air pollution, air pollution impacts, air quality monitoring, air quality trends, and control strategies. Provides profiles of the problem in Beijing, Los Angeles, Mexico City, India, Cairo, Sao Paulo, and…

  2. Zero-Net-Charge Air Ionizer

    NASA Technical Reports Server (NTRS)

    Woods, W. R., Jr.

    1985-01-01

    Instrument monitors air supplied by air ionizer and regulates ionizer to ensure net charge neutral. High-impedance electrometer and nulling control amplifier regulate output of air ionizer. Primarily intended to furnish ionized air having no net charge, instrument adaptable to generating air with positive or negative net charge is so desired. Useful where integrated circuit chips are manufactured, inspected, tested or assembled.

  3. Air contaminants in a submarine equipped with air independent propulsion.

    PubMed

    Persson, Ola; Ostberg, Christina; Pagels, Joakim; Sebastian, Aleksandra

    2006-11-01

    The Swedish Navy has operated submarines equipped with air independent propulsion for two decades. This type of submarine can stay submerged for periods far longer than other non-nuclear submarines are capable of. The air quality during longer periods of submersion has so far not been thoroughly investigated. This study presents results for a number of air quality parameters obtained during more than one week of continuous submerged operation. The measured parameters are pressure, temperature, relative humidity, oxygen, carbon dioxide, hydrogen, formaldehyde and other volatile organic compounds, ozone, nitrogen dioxide, particulate matter and microbiological contaminants. The measurements of airborne particles demonstrate that air pollutants typically occur at a low baseline level due to high air exchange rates and efficient air-cleaning devices. However, short-lived peaks with comparatively high concentrations occur, several of the sources for these have been identified. The concentrations of the pollutants measured in this study do not indicate a build-up of hazardous compounds during eight days of submersion. It is reasonable to assume that a substantial build-up of the investigated contaminants is not likely if the submersion period is prolonged several times, which is the case for modern submarines equipped with air independent propulsion.

  4. Air Safety Spinoffs

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Weight saving-even a matter of a few pounds-is an important consideration in airplane design and . construction. Boeing saved 200 pounds simply by substituting a new type of compressed gas cylinder on their 747 commercial airliners. For quickly evacuating passengers in the event of a ground emergency the 747 escape chutes allow ' passengers to slide to safety from the two-story height of the cabin deck. The chutes pop out of exitways and are automatically inflated in seconds by compressed air stored in pressure vessels. Boeing's weight saving resulted from a recent changeover to a new type of pressure vessel built by Structural Composites Industries Inc. of Azusa, Cal. The company employs technology originally developed for rocket motor casings; the cylinders are constructed by winding fibers around an aluminum liner. This technique offers high strength for very low weight-in this case 60 percent less than the pressure vessels earlier used on the 747. Another contribution to improved air safety is an underwater locator device. Called the "Pinger," it uses sonar techniques to locate aircraft crashed in water-or, more specifically, to recover the flight recorder aboard the airplane. Its recovery provides clues as to what caused the accident and suggests measures to prevent similar future occurrences. Until recently, there was no way to recover flight recorders aboard aircraft lost in water crashes. The Pinger, now serving 95 percent of the airline industry, provides an answer. Key element of the Pinger system is a small, battery-powered transmitter, or homing beacon, included as part of the recorder package. For as long as 30 days, the transmitter sends out an acoustic signal from water depths up to 20,000 feet. The other element of the system is a receiver, used by search crews to home in on the transmitter's signal. Originating as a U.S. Navy project, this device was refined and further developed by NASA's Langley Research Center to retrieve submerged nose cones

  5. Air Leakage and Air Transfer Between Garage and Living Space

    SciTech Connect

    Rudd, A.

    2014-09-01

    This research project focused on evaluation of air transfer between the garage and living space in a single-family detached home constructed by a production homebuilder in compliance with the 2009 International Residential Code and the 2009 International Energy Conservation Code. The project gathered important information about the performance of whole-building ventilation systems and garage ventilation systems as they relate to minimizing flow of contaminated air from garage to living space. A series of 25 multi-point fan pressurization tests and additional zone pressure diagnostic testing characterized the garage and house air leakage, the garage-to-house air leakage, and garage and house pressure relationships to each other and to outdoors using automated fan pressurization and pressure monitoring techniques. While the relative characteristics of this house may not represent the entire population of new construction configurations and air tightness levels (house and garage) throughout the country, the technical approach was conservative and should reasonably extend the usefulness of the results to a large spectrum of house configurations from this set of parametric tests in this one house. Based on the results of this testing, the two-step garage-to-house air leakage test protocol described above is recommended where whole-house exhaust ventilation is employed. For houses employing whole-house supply ventilation (positive pressure) or balanced ventilation (same pressure effect as the Baseline condition), adherence to the EPA Indoor airPLUS house-to-garage air sealing requirements should be sufficient to expect little to no garage-to-house air transfer.

  6. Community Multi-scale Air Quality (CMAQ) Modeling System for Air Quality Management

    EPA Pesticide Factsheets

    CMAQ simultaneously models multiple air pollutants including ozone, particulate matter and a variety of air toxics to help air quality managers determine the best air quality management scenarios for their communities, regions and states.

  7. 76 FR 66717 - Notification of a Public Teleconference of the Clean Air Scientific Advisory Committee Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-27

    ... AGENCY Notification of a Public Teleconference of the Clean Air Scientific Advisory Committee Air Monitoring and Methods Subcommittee AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY... announces a public teleconference of the Clean Air Scientific Advisory Committee (CASAC) Air Monitoring...

  8. 76 FR 54462 - Notification of a Public Teleconference; Clean Air Scientific Advisory Committee; Air Monitoring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... teleconference of the Air Monitoring and Methods Subcommittee (AMMS) of the Clean Air Scientific Advisory... AGENCY Notification of a Public Teleconference; Clean Air Scientific Advisory Committee; Air Monitoring and Methods Subcommittee AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY:...

  9. Flight testing air-to-air missiles for flutter

    NASA Technical Reports Server (NTRS)

    Kutschinski, C. R.

    1975-01-01

    The philosophy of the design of air-to-air missiles and hence of flight testing them for flutter differs from that of manned aircraft. Primary emphasis is put on analytical and laboratory evaluation of missile susceptibility to aeroelastic and aero-servo-elastic instabilities and uses flight testing for confirmation of the absence of such instabilities. Flight testing for flutter is accomplished by using specially instrumented programmed missiles, air or ground launched with a booster to reach the extreme flight conditions of tactical use, or by using guided missiles with telemetered performance data. The instrumentation and testing techniques are discussed along with the success of recent flight tests.

  10. [Air quality control systems: heating, ventilating, and air conditioning (HVAC)].

    PubMed

    Bellucci Sessa, R; Riccio, G

    2004-01-01

    After a brief illustration of the principal layout schemes of Heating, Ventilating, and Air Conditioning (HVAC), the first part of this paper summarizes the standards, both voluntary and compulsory, regulating HVAC facilities design and installation with regard to the question of Indoor Air Quality (IAQ). The paper then examines the problem of ventilation systems maintenance and the essential hygienistic requirements in whose absence HVAC facilities may become a risk factor for people working or living in the building. Lastly, the paper deals with HVAC design strategies and methods, which aim not only to satisfy comfort and air quality requirements, but also to ensure easy and effective maintenance procedures.

  11. Radioxenon spiked air

    DOE PAGES

    Watrous, Matthew G.; Delmore, James E.; Hague, Robert K.; ...

    2015-08-27

    Four of the radioactive xenon isotopes (131mXe, 133mXe, 133Xe and 135Xe) with half-lives ranging from 9 h to 12 days are produced from nuclear fission and can be detected from days to weeks following their production and release. Being inert gases, they are readily transported through the atmosphere. Sources for release of radioactive xenon isotopes include operating nuclear reactors via leaks in fuel rods, medical isotope production facilities, and nuclear weapons' detonations. They are not normally released from fuel reprocessing due to the short half-lives. The Comprehensive Nuclear-Test-Ban Treaty has led to creation of the International Monitoring System. The Internationalmore » Monitoring System, when fully implemented, will consist of one component with 40 stations monitoring radioactive xenon around the globe. Monitoring these radioactive xenon isotopes is important to the Comprehensive Nuclear-Test-Ban Treaty in determining whether a seismically detected event is or is not a nuclear detonation. A variety of radioactive xenon quality control check standards, quantitatively spiked into various gas matrices, could be used to demonstrate that these stations are operating on the same basis in order to bolster defensibility of data across the International Monitoring System. This study focuses on Idaho National Laboratory's capability to produce three of the xenon isotopes in pure form and the use of the four xenon isotopes in various combinations to produce radioactive xenon spiked air samples that could be subsequently distributed to participating facilities.« less

  12. Airing Out Anthrax

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The AiroCide TiO2 is an air-purifier that kills 93.3 percent of airborne pathogens that pass through it, including Bacillus anthraci, more commonly known as anthrax. It is essentially a spinoff of KES Science & Technology, Inc.'s Bio-KES system, a highly effective device used by the produce industry for ethylene gas removal to aid in preserving the freshness of fruits, vegetables, and flowers. The TiO2-based ethylene removal technology that is incorporated into the company's AiroCide TiO2 and Bio-KES products was first integrated into a pair of plant-growth chambers known as ASTROCULTURE(TM) and ADVANCED ASTROCULTURE(TM). Both chambers have housed commercial plant growth experiments in space on either the Space Shuttle or the International Space Station. The AiroCide TiO2 also has a proven record of destroying 98 percent of other airborne pathogens, such as microscopic dust mites, molds, and fungi. Moreover, the device is a verified killer of Influenza A (flu), E. coli, Staphylococcus aureas, Streptococcus pyogenes, and Mycoplasma pneumoniae, among many other harmful viruses.

  13. Air pollutants and cough.

    PubMed

    Joad, Jesse P; Sekizawa, Shin-ichi; Chen, Chao-Yin; Bonham, Ann C

    2007-01-01

    Epidemiological studies have shown that exposure to air pollution is associated with respiratory symptoms and decreases in lung function. This paper reviews recent literature showing that exposure to particulate matter, irritant gases, environmental tobacco smoke (ETS), mixed pollutants, and molds is associated with an increase in cough and wheeze. Some pollutants, like particulate matter and mixed pollutants, appear to increase cough at least as much as wheeze. Others, like irritant gases, appear to increase wheeze more than cough. For ETS, exposure during childhood is associated with cough and wheeze in adulthood, suggesting that the pollutant permanently alters some important aspect of the lungs, immune system or nervous system. We have shown in animal studies that pollutants change the neural control of airways and cough. Second hand smoke (SHS) exposure lengthened stimulated apnoea, increased the number of stimulated coughs, and augmented the degree of stimulated bronchoconstriction. The mechanisms included enhanced reactivity of the peripheral sensory neurones and second-order neurones in the nucleus tractus solitarius (NTS). NTS effects were due to a substance P mechanism at least in part. Ozone and allergen increased the intrinsic excitability of second-order neurones in the NTS. The animal studies suggest that the cough and wheeze experienced by humans exposed to pollutants may involve plasticity in the nervous system.

  14. Air turbo-ramjet engine

    SciTech Connect

    Kepler, C.E.

    1991-12-24

    This patent describes a jet engine capable of being used to power an aircraft throughout a range of speeds from subsonic to high supersonic. It comprises means for bounding an internal passage centered on an axis and including, in succession as considered in the direction of axial flow of incoming air into and through the passage, a fixed-area air inlet section, a diverging passage section, a mixing section, a combustion section, and an outlet section; fan means situated in the air inlet section and including a rotor mounted in the bounding means for rotation about the axis and including a plurality of circumferentially spaced rotor blade members; means for selectively rotating the rotor about the axis with attendant impelling action of the rotor blade members on the air flowing therebetween; and means for selectively discharging air from a region of the passage situated between the air inlet section and the diverging passage section to the exterior of the bounding means, both at subsonic and supersonic speeds of the aircraft, when the amount of incoming air passing through the fixed-area inlet section exceeds that required in the combustion section.

  15. Ports Primer: 7.2 Air Emissions

    EPA Pesticide Factsheets

    Near-port communities are often disproportionately impacted by air emissions due to port operations, goods movement operations and other industries that may be co-located with ports. Air emissions at ports also impact regional air quality.

  16. Local Air Quality Conditions and Forecasts

    MedlinePlus

    Local Air Quality Conditions Zip Code: State : My Current Location Map Center Forecast AQI Current AQI Current Ozone Current PM ... Ozone Loop PM Loop AQI: Good (0 - 50) Air quality is considered satisfactory, and air pollution poses little ...

  17. 1990 Clean Air Act Amendment Summary

    EPA Pesticide Factsheets

    In 1989, President George W. Bush proposed revisions to the Clean Air Act designed to curb acid rain, urban air pollution, and toxic air emissions. The proposal also called for establishing a national permits program.

  18. Air Sensor Toolbox: Resources and Funding

    EPA Pesticide Factsheets

    EPA’s Air Sensor Toolbox provides information and guidance on new low-cost compact technologies for measuring air quality. It provides information to help citizens more effectively and accurately collect air quality data in their community.

  19. Transportation, Air Pollution, and Climate Change

    MedlinePlus

    ... Share Facebook Twitter Google+ Pinterest Contact Us Transportation, Air Pollution, and Climate Change Accomplishments & Successes View successes from ... reduce carbon pollution. Carbon pollution from transportation Other Air Pollution Learn about smog, soot, ozone, and other air ...

  20. 40 CFR 61.34 - Air sampling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Beryllium § 61.34 Air... detect maximum concentrations of beryllium in the ambient air. (b) All monitoring sites shall be...

  1. 40 CFR 61.34 - Air sampling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Beryllium § 61.34 Air... detect maximum concentrations of beryllium in the ambient air. (b) All monitoring sites shall be...

  2. 40 CFR 61.34 - Air sampling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Beryllium § 61.34 Air... detect maximum concentrations of beryllium in the ambient air. (b) All monitoring sites shall be...

  3. 40 CFR 61.34 - Air sampling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Beryllium § 61.34 Air... detect maximum concentrations of beryllium in the ambient air. (b) All monitoring sites shall be...

  4. 40 CFR 61.34 - Air sampling.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Beryllium § 61.34 Air... detect maximum concentrations of beryllium in the ambient air. (b) All monitoring sites shall be...

  5. The Community College of the Air Force

    ERIC Educational Resources Information Center

    Kaapke, Lyle D.; Wojciechowske, William A.

    1977-01-01

    The Community College of the Air Force is unique as a postsecondary occupational education institution because it integrates Air Force technical education and civilian-related education into programs which are totally responsive to the Air Force community. (JG)

  6. Ozone, Air Quality, and Asthma (For Parents)

    MedlinePlus

    ... How Poor Air Quality Affects People With Asthma Air pollution is a problem for everyone — not just people ... asthma. Studies have shown that high levels of air pollution can be associated with decreased lung function and ...

  7. INEEL AIR MODELING PROTOCOL ext

    SciTech Connect

    C. S. Staley; M. L. Abbott; P. D. Ritter

    2004-12-01

    Various laws stemming from the Clean Air Act of 1970 and the Clean Air Act amendments of 1990 require air emissions modeling. Modeling is used to ensure that air emissions from new projects and from modifications to existing facilities do not exceed certain standards. For radionuclides, any new airborne release must be modeled to show that downwind receptors do not receive exposures exceeding the dose limits and to determine the requirements for emissions monitoring. For criteria and toxic pollutants, emissions usually must first exceed threshold values before modeling of downwind concentrations is required. This document was prepared to provide guidance for performing environmental compliance-driven air modeling of emissions from Idaho National Engineering and Environmental Laboratory facilities. This document assumes that the user has experience in air modeling and dose and risk assessment. It is not intended to be a "cookbook," nor should all recommendations herein be construed as requirements. However, there are certain procedures that are required by law, and these are pointed out. It is also important to understand that air emissions modeling is a constantly evolving process. This document should, therefore, be reviewed periodically and revised as needed. The document is divided into two parts. Part A is the protocol for radiological assessments, and Part B is for nonradiological assessments. This document is an update of and supersedes document INEEL/INT-98-00236, Rev. 0, INEEL Air Modeling Protocol. This updated document incorporates changes in some of the rules, procedures, and air modeling codes that have occurred since the protocol was first published in 1998.

  8. Other Priority Air Toxics in New England | Air Toxics | New ...

    EPA Pesticide Factsheets

    2017-04-10

    The air toxics of greatest concern in New England were selected due to risk modeling for only the inhalation route of exposure and these pollutants exceeded the health benchmarks in one or more of the New England states.

  9. Inertial impaction air sampling device

    SciTech Connect

    Dewhurst, K.H.

    1987-12-10

    An inertial impactor to be used in an air sampling device for collection of respirable size particles in ambient air which may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry. 3 figs.

  10. Inertial impaction air sampling device

    SciTech Connect

    Dewhurst, K.H.

    1990-05-22

    An inertial impactor is designed which is to be used in an air sampling device for collection of respirable size particles in ambient air. The device may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry. 3 figs.

  11. Inertial impaction air sampling device

    DOEpatents

    Dewhurst, Katharine H.

    1990-01-01

    An inertial impactor to be used in an air sampling device for collection of respirable size particles in ambient air which may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry.

  12. Instrumentation for air quality measurements.

    NASA Technical Reports Server (NTRS)

    Loewenstein, M.

    1973-01-01

    Comparison of the new generation of air quality monitoring instruments with some more traditional methods. The first generation of air quality measurement instruments, based on the use of oxidant coulometric cells, nitrogen oxide colorimetry, carbon monoxide infrared analyzers, and other types of detectors, is compared with new techniques now coming into wide use in the air monitoring field and involving the use of chemiluminescent reactions, optical absorption detectors, a refinement of the carbon monoxide infrared analyzer, electrochemical cells based on solid electrolytes, and laser detectors.

  13. Study of air pollutant detectors

    NASA Technical Reports Server (NTRS)

    Gutshall, P. L.; Bowles, C. Q.

    1974-01-01

    The application of field ionization mass spectrometry (FIMS) to the detection of air pollutants was investigated. Current methods are reviewed for measuring contaminants of fixed gases, sulfur compounds, nitrogen oxides, hydrocarbons, and particulates. Two enriching devices: the dimethyl silicone rubber membrane separator, and the selective adsorber of polyethylene foam were studied along with FIMS. It is concluded that the membrane enricher system is not a suitable method for removing air pollutants. However, the FIMS shows promise as a useable system for air pollution detection.

  14. Air bags and the skin.

    PubMed

    Corazza, Monica; Trincone, Silvana; Zampino, Maria Rosaria; Virgili, Annarosa

    2004-01-01

    Air bags, fitted in the majority of new automobiles, are safety devices activated when a sudden deceleration causes the ignition of a propellant cartridge containing sodium azide. The bag is inflated by nitrogen liberated during the combustion. Deployment releases various high-temperature gases, including nitrogen and carbon dioxide, and produces sodium hydroxide, a highly irritant alkaline substance. In about 7%-8% of cases, air bags cause dermatologic injuries such as traumatic lesions, irritant dermatitis, and chemical and thermal burns. Nondermatologic lesions, such as ocular damage (alkali keratitis, corneal abrasions), ear lesions, bone fractures, and contusive damage can also be caused by air bag deployment.

  15. Advanced air revitalization system testing

    NASA Technical Reports Server (NTRS)

    Heppner, D. B.; Hallick, T. M.; Schubert, F. H.

    1983-01-01

    A previously developed experimental air revitalization system was tested cyclically and parametrically. One-button startup without manual interventions; extension by 1350 hours of tests with the system; capability for varying process air carbon dioxide partial pressure and humidity and coolant source for simulation of realistic space vehicle interfaces; dynamic system performance response on the interaction of the electrochemical depolarized carbon dioxide concentrator, the Sabatier carbon dioxide reduction subsystem, and the static feed water electrolysis oxygen generation subsystem, the carbon dioxide concentrator module with unitized core technology for the liquid cooled cell; and a preliminary design for a regenerative air revitalization system for the space station are discussed.

  16. Williams Air Force Base Air Quality Monitoring Study,

    DTIC Science & Technology

    1980-07-01

    During monitoring operations conducted from five ground stations at Williams Air Force Base (WAFB) near Phoenix, Arizona, air quallity data were collected... chemical spraying, which could explain the higher levels of THC. Pollution roses for CO and THC were constructed using April 17 - June 18 data, and the...mixing depth). They also provided information on the vertical mixing properties of the atmosphere and (as input for model calculations) insight into

  17. 33 CFR 334.1300 - Blying Sound area, Gulf of Alaska, Alaska; air-to-air gunnery practice area, Alaskan Air Command...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Alaska; air-to-air gunnery practice area, Alaskan Air Command, U.S. Air Force. 334.1300 Section 334.1300... gunnery practice area, Alaskan Air Command, U.S. Air Force. (a) The danger zone. A rhomboidal area... Air Command, U.S. Air Force, Anchorage, Alaska, or such agencies as he may designate. (Sec. 7, 40...

  18. 33 CFR 334.1300 - Blying Sound area, Gulf of Alaska, Alaska; air-to-air gunnery practice area, Alaskan Air Command...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Alaska; air-to-air gunnery practice area, Alaskan Air Command, U.S. Air Force. 334.1300 Section 334.1300... gunnery practice area, Alaskan Air Command, U.S. Air Force. (a) The danger zone. A rhomboidal area... Air Command, U.S. Air Force, Anchorage, Alaska, or such agencies as he may designate. (Sec. 7, 40...

  19. 33 CFR 334.1300 - Blying Sound area, Gulf of Alaska, Alaska; air-to-air gunnery practice area, Alaskan Air Command...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Alaska; air-to-air gunnery practice area, Alaskan Air Command, U.S. Air Force. 334.1300 Section 334.1300... gunnery practice area, Alaskan Air Command, U.S. Air Force. (a) The danger zone. A rhomboidal area... Air Command, U.S. Air Force, Anchorage, Alaska, or such agencies as he may designate. (Sec. 7, 40...

  20. 33 CFR 334.1300 - Blying Sound area, Gulf of Alaska, Alaska; air-to-air gunnery practice area, Alaskan Air Command...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Alaska; air-to-air gunnery practice area, Alaskan Air Command, U.S. Air Force. 334.1300 Section 334.1300... gunnery practice area, Alaskan Air Command, U.S. Air Force. (a) The danger zone. A rhomboidal area... Air Command, U.S. Air Force, Anchorage, Alaska, or such agencies as he may designate. (Sec. 7, 40...

  1. Radioxenon spiked air

    SciTech Connect

    Watrous, Matthew G.; Delmore, James E.; Hague, Robert K.; Houghton, Tracy P.; Jenson, Douglas D.; Mann, Nick R.

    2015-08-27

    Four of the radioactive xenon isotopes (131mXe, 133mXe, 133Xe and 135Xe) with half-lives ranging from 9 h to 12 days are produced from nuclear fission and can be detected from days to weeks following their production and release. Being inert gases, they are readily transported through the atmosphere. Sources for release of radioactive xenon isotopes include operating nuclear reactors via leaks in fuel rods, medical isotope production facilities, and nuclear weapons' detonations. They are not normally released from fuel reprocessing due to the short half-lives. The Comprehensive Nuclear-Test-Ban Treaty has led to creation of the International Monitoring System. The International Monitoring System, when fully implemented, will consist of one component with 40 stations monitoring radioactive xenon around the globe. Monitoring these radioactive xenon isotopes is important to the Comprehensive Nuclear-Test-Ban Treaty in determining whether a seismically detected event is or is not a nuclear detonation. A variety of radioactive xenon quality control check standards, quantitatively spiked into various gas matrices, could be used to demonstrate that these stations are operating on the same basis in order to bolster defensibility of data across the International Monitoring System. This study focuses on Idaho National Laboratory's capability to produce three of the xenon isotopes in pure form and the use of the four xenon isotopes in various combinations to produce radioactive xenon spiked air samples that could be subsequently distributed to participating facilities.

  2. Air Leakage and Air Transfer Between Garage and Living Space

    SciTech Connect

    Rudd, Armin

    2014-09-01

    This research project focused on evaluation of air transfer between the garage and living space in a single-family detached home constructed by a production homebuilder in compliance with the 2009 International Residential Code and the 2009 International Energy Conservation Code. The project gathered important information about the performance of whole-building ventilation systems and garage ventilation systems as they relate to minimizing flow of contaminated air from garage to living space. A series of 25 multi-point fan pressurization tests and additional zone pressure diagnostic testing characterized the garage and house air leakage, the garage-to-house air leakage, and garage and house pressure relationships to each other and to outdoors using automated fan pressurization and pressure monitoring techniques. While the relative characteristics of this house may not represent the entire population of new construction configurations and air tightness levels (house and garage) throughout the country, the technical approach was conservative and should reasonably extend the usefulness of the results to a large spectrum of house configurations from this set of parametric tests in this one house. Based on the results of this testing, the two-step garage-to-house air leakage test protocol described above is recommended where whole-house exhaust ventilation is employed.

  3. Rooftop Unitary Air Conditioner with Integral Dedicated Outdoor Air System

    SciTech Connect

    Tiax Llc

    2006-02-28

    Energy use of rooftop and other unitary air-conditioners in commercial applications accounts for about 1 quad (10{sup 15} Btu) of primary energy use annually in the U.S. [Reference 7]. The realization that this cooling equipment accounts for the majority of commercial building cooled floorspace and the majority also of commercial building energy use has spurred development of improved-efficiency equipment as well as development of stricter standards addressing efficiency levels. Another key market driver affecting design of rooftop air-conditioning equipment has been concern regarding comfort and the control of humidity. Trends for increases in outdoor air ventilation rates in certain applications, and the increasing concern about indoor air quality problems associated with humidity levels and moisture in buildings points to a need for improved dehumidification capability in air-conditioning equipment of all types. In many cases addressing this issue exacerbates energy efficiency, and vice versa. The integrated dedicated outdoor air system configuration developed in this project addresses both energy and comfort/humidity issues.

  4. Pollution control of industrial wastewater from soap and oil industries: a case study.

    PubMed

    Abdel-Gawad, S; Abdel-Shafy, M

    2002-01-01

    Industrial wastewater from soap and oil industries represents a heavy pollution source on their receiving water body. This paper studies a case of pollution control at Tanta Soap and Oil Company, Banha Factory, Egypt. The factory production includes soap, edible oil, and animal fodder. About 4,347 m3/day of industrial wastewater effluent was discharged via gravity sewers to the public sewerage system. Most of the effluent was cooling water because the cooling process in the factory was open circle. In spite of the huge quantity of cooling water being disposed of, disposal of wastewater was violating pertinent legislation. Three procedures were used for controlling the pollution at the Banha Factory. Firstly, all open circuit cooling systems were converted to closed circuit thus reducing the quantity of the discharged wastewater down to 767 m3/day. Secondly, the heavily polluted oil and grease (O&G) wastewater from the refinery unit is treated via two gravity oil separator (GOS) units, dissolved air floatation (DAF), and biological units in order to reduce the high levels of O&G, BOD, COD, and SS to the allowable limits. Thirdly, the heavily polluted waste effluent from the 'red water' saponification unit is treated separately by acidification to convert the emulsified fatty acid to free form in order to be separated through an oil separation unit. The effluent is then passed to liming stage to neutralize excess acidity and precipitate some of the dissolved matters. The mixture is finally clarified and the pH is adjusted to the allowable limits. The effluent wastewater from the three processes is collected and mixed in a final equalization tank for discharging effluent to the public sewerage system. The characteristics of the effluent water are very good with respect to the allowable Egyptian limits for discharging effluent to the public sewerage system.

  5. Optical air data systems and methods

    NASA Technical Reports Server (NTRS)

    Caldwell, Loren M. (Inventor); O'Brien, Martin J. (Inventor); Weimer, Carl S. (Inventor); Nelson, Loren D. (Inventor)

    2005-01-01

    Systems and methods for sensing air outside a moving aircraft are presented. In one embodiment, a system includes a laser for generating laser energy. The system also includes one or more transceivers for projecting the laser energy as laser radiation to the air. Subsequently, each transceiver receives laser energy as it is backscattered from the air. A computer processes signals from the transceivers to distinguish molecular scattered laser radiation from aerosol scattered laser radiation and determines one or more air parameters based on the scattered laser radiation. Such air parameters may include air speed, air pressure, air temperature and aircraft orientation angle, such as yaw, angle of attack and sideslip.

  6. Air Pollution: Current and Future Challenges

    EPA Pesticide Factsheets

    Despite the dramatic progress to date, air pollution continues to threaten Americans’ health and welfare. The main obstacles are climate change, conventional air pollution, and ozone layer depletion.

  7. Optical air data systems and methods

    NASA Technical Reports Server (NTRS)

    Caldwell, Loren M. (Inventor); Tang, Shoou-yu (Inventor); O'Brien, Martin (Inventor)

    2010-01-01

    Systems and methods for sensing air outside a moving aircraft are presented. In one embodiment, a system includes a laser for generating laser energy. The system also includes one or more transceivers for projecting the laser energy as laser radiation to the air. Subsequently, each transceiver receives laser energy as it is backscattered from the air. A computer processes signals from the transceivers to distinguish molecular scattered laser radiation from aerosol scattered laser radiation and determines one or more air parameters based on the scattered laser radiation. Such air parameters may include air speed, air pressure, air temperature and aircraft orientation angle, such as yaw, angle of attack and sideslip.

  8. Introduction to Indoor Air Quality

    MedlinePlus

    ... Building materials and furnishings as diverse as: Deteriorated asbestos-containing insulation Newly installed flooring, upholstery or carpet ... more about indoor air pollutants and sources of: Asbestos Biological Pollutants Carbon Monoxide (CO) Formaldehyde/Pressed Wood ...

  9. The Challenge of Clean Air

    ERIC Educational Resources Information Center

    Turner, John M.

    1974-01-01

    The country's first two-year education program in Air Pollution Technology trains students to work for industry or government. Although two to three jobs are available for each graduate, attracting interested students remains a challenge. (AJ)

  10. A Breath of Fresh Air.

    ERIC Educational Resources Information Center

    Freeman, Laurie

    1996-01-01

    A new elementary school in New Hampshire uses innovative European ventilation technology to ensure excellent air quality. Combined with high-efficiency lighting, the system should reduce energy consumption by 10 to 20%, compared with a traditional facility. (MLF)

  11. Air tamponade of the heart

    PubMed Central

    Orłowski, Tadeusz; Iwanowicz, Katarzyna; Snarska, Jadwiga

    2016-01-01

    Pneumopericardium is a rare disease defined as the presence of air or gas in the pericardial sac. Among the etiological factors, the following stand out: chest trauma, barotrauma, air-containing fistulas between the pericardium and the surrounding structures, secondary gas production by microorganisms growing in the pericardial sac, and iatrogenic factors. Until now, spontaneous pneumopericardium has been considered a harmless and temporary state, but a review of clinical cases indicates that the presence of air in the pericardium can lead to cardiac tamponade and life-threatening hemodynamic disturbances. We present the case of an 80-year-old patient with a chronic bronchopericardial fistula, who suffered from a cardiac arrest due to air tamponade of the heart. PMID:27516791

  12. Air Pollution Affects Community Health

    ERIC Educational Resources Information Center

    Shy, Carl M.; Finklea, John F.

    1973-01-01

    Community Health and Environmental Surveillance System (CHESS), a nationwide program relating community health to environmental quality, is designed to evaluate existing environmental standards, obtain health intelligence for new standards, and document health benefits of air pollution control. (BL)

  13. Air entrainment in hairy surfaces

    NASA Astrophysics Data System (ADS)

    Nasto, Alice; Regli, Marianne; Brun, P.-T.; Alvarado, José; Clanet, Christophe; Hosoi, A. E.

    2016-07-01

    Motivated by diving semiaquatic mammals, we investigate the mechanism of dynamic air entrainment in hairy surfaces submerged in liquid. Hairy surfaces are cast out of polydimethylsiloxane elastomer and plunged into a fluid bath at different velocities. Experimentally, we find that the amount of air entrained is greater than what is expected for smooth surfaces. Theoretically, we show that the hairy surface can be considered as a porous medium and we describe the air entrainment via a competition between the hydrostatic forcing and the viscous resistance in the pores. A phase diagram that includes data from our experiments and biological data from diving semiaquatic mammals is included to place the model system in a biological context and predict the regime for which the animal is protected by a plastron of air.

  14. Clean Air Excellence Award Recipients

    EPA Pesticide Factsheets

    Recipients are organized by award category within each year: Clean Air Technology, Community Action, Education/Outreach, Regulatory/Policy Innovations, Transportation Efficiency Innovations, Thomas W. Zosel individual, and Gregg Cooke Visionary Program.

  15. Psychological reactions to air pollution

    SciTech Connect

    Evans, G.W.; Colome, S.D.; Shearer, D.F.

    1988-02-01

    Interviews with a large representative sample of Los Angeles residents reveal that these citizens are somewhat aware and concerned about air pollution, but not knowledgeable about its causes. Direct behaviors to reduce causes of pollution or one's exposure to it are rare. A moderate percentage of people seek out information about air pollution or complain about it. Fewer follow state health advisories by reducing automobile driving or restricting activity during air pollution episodes. Preliminary modeling of citizen compliance with air pollution health advisories suggest that personal beliefs about negative health effects are a important predictor of compliance. Finally, modest but significant relationships are noted between ambient photochemical oxidants and anxiety symptoms. The latter finding controls for age, socioeconomic status, and temperature.

  16. Predictors of alveolar air leaks.

    PubMed

    Loran, David B; Woodside, Kenneth J; Cerfolio, Robert J; Zwischenberger, Joseph B

    2002-08-01

    Persistent air leaks are caused by the failure of the postoperative lung to achieve a configuration that is physiologically amenable to healing. The raw pulmonary surface caused by the dissection of the fissure often is separated from the pleura, and the air leak fails to close. Additionally, higher air flow thorough an alveolar-pleural fistula seems to keep the fistula open. Other factors that interfere with wound healing, such as steroid use, diabetes, or malnutrition, can result in persistence of the leak. A thoracic surgeon can minimize the incidence of air leak through meticulous surgical technique and can identify patients in whom the balance of risks (Table 1) and benefits warrant operative intervention based on an understanding of the underlying pathophysiology.

  17. Air Modeling - Observational Meteorological Data

    EPA Pesticide Factsheets

    Observed meteorological data for use in air quality modeling consist of physical parameters that are measured directly by instrumentation, and include temperature, dew point, wind direction, wind speed, cloud cover, cloud layer(s), ceiling height,

  18. Manual on indoor air quality

    SciTech Connect

    Diamond, R.C.; Grimsrud, D.T.

    1983-12-01

    This reference manual was prepared to assist electric utilities in helping homeowners, builders, and new home buyers to understand a broad range of issues related to indoor air quality. The manual is directed to technically knowledgeable persons employed by utility companies - the customer service or marketing representative, applications engineer, or technician - who may not have specific expertise in indoor air quality issues. In addition to providing monitoring and control techniques, the manual summarizes the link between pollutant concentrations, air exchange, and energy conservation and describes the characteristics and health effects of selected pollutants. Where technical information is too lengthy or complex for inclusion in this volume, reference sources are given. Information for this manual was gathered from technical studies, manufacturers' information, and other materials from professional societies, institutes, and associations. The aim has been to provide objective technical and descriptive information that can be used by utility personnel to make informed decisions about indoor air quality issues.

  19. Indoor Air Quality in Apartments

    EPA Pesticide Factsheets

    Apartments can have the same indoor air problems as single-family homes because many of the pollution sources, such as the interior building materials, furnishings, and household products, are similar.

  20. Air cushion vehicles: A briefing

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.; Finnegan, P. M.

    1971-01-01

    Experience and characteristics; the powering, uses, and implications of large air cushion vehicles (ACV); and the conceptual design and operation of a nuclear powered ACV freighter and supporting facilities are described.